BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|148298677 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] (520 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148298764 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] 1053 0.0 gi|148298677 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] 1053 0.0 gi|5031751 hydroxymethylglutaryl-CoA synthase 2 [Homo sapiens] 665 0.0 gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 30 4.1 gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo... 30 7.0 gi|87196347 zinc finger, B-box domain containing [Homo sapiens] 30 7.0 gi|109715849 chromosome 6 open reading frame 204 isoform b [Homo... 30 7.0 gi|226246608 RNA polymerase II associated protein 2 [Homo sapiens] 29 9.1 gi|27886520 nuclear factor of activated T-cells 5 isoform a [Hom... 29 9.1 gi|5729945 nuclear factor of activated T-cells 5 isoform c [Homo... 29 9.1 gi|164419746 nuclear factor of activated T-cells 5 isoform d [Ho... 29 9.1 gi|164419744 nuclear factor of activated T-cells 5 isoform b [Ho... 29 9.1 gi|27886524 nuclear factor of activated T-cells 5 isoform a [Hom... 29 9.1 >gi|148298764 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] Length = 520 Score = 1053 bits (2722), Expect = 0.0 Identities = 520/520 (100%), Positives = 520/520 (100%) Query: 1 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT 60 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT Sbjct: 1 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT 60 Query: 61 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI 120 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI Sbjct: 61 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI 120 Query: 121 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL 180 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL Sbjct: 121 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL 180 Query: 181 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI Sbjct: 181 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240 Query: 241 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA 300 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA Sbjct: 241 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA 300 Query: 301 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY 360 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY Sbjct: 301 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY 360 Query: 361 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP 420 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP Sbjct: 361 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP 420 Query: 421 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG 480 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG Sbjct: 421 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG 480 Query: 481 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH 520 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH Sbjct: 481 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH 520 >gi|148298677 hydroxymethylglutaryl-CoA synthase 1 [Homo sapiens] Length = 520 Score = 1053 bits (2722), Expect = 0.0 Identities = 520/520 (100%), Positives = 520/520 (100%) Query: 1 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT 60 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT Sbjct: 1 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT 60 Query: 61 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI 120 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI Sbjct: 61 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI 120 Query: 121 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL 180 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL Sbjct: 121 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL 180 Query: 181 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI Sbjct: 181 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240 Query: 241 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA 300 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA Sbjct: 241 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA 300 Query: 301 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY 360 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY Sbjct: 301 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY 360 Query: 361 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP 420 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP Sbjct: 361 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP 420 Query: 421 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG 480 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG Sbjct: 421 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG 480 Query: 481 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH 520 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH Sbjct: 481 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH 520 >gi|5031751 hydroxymethylglutaryl-CoA synthase 2 [Homo sapiens] Length = 508 Score = 665 bits (1717), Expect = 0.0 Identities = 315/467 (67%), Positives = 387/467 (82%) Query: 4 SLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDRE 63 ++PL WPKDVGI+ALE+YFP+QYVDQ +LEKY+ V+AGKYT+GLGQ +MGFC+ +E Sbjct: 41 AVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQE 100 Query: 64 DINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGI 123 DINSLC+TVVQ LMER L +D +GRLEVGTETIIDKSK+VKT LM+LF++SGNTDIEGI Sbjct: 101 DINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGI 160 Query: 124 DTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGP 183 DTTNACYGGTA++FNA NW+ESSSWDGRYA+VV GDIAVY +GNARPTGG GAVA+LIGP Sbjct: 161 DTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGP 220 Query: 184 NAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQ 243 APL ERGLRGTHM++ YDFYKP++ SEYPIVDGKLSIQCYL ALDRCY+ Y KKI Q Sbjct: 221 KAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQ 280 Query: 244 WQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGD 303 W++ G+D+ FTL+D +MIFH+P+CK+VQKSLAR++ NDFL+ + + S+Y GLEAFG Sbjct: 281 WKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGG 340 Query: 304 VKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQ 363 +KLEDTY ++D++KA +KAS ++F +KTKASL +S NGNMYTSS+YG LAS+L+ +S Q Sbjct: 341 LKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQ 400 Query: 364 QLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVF 423 +LAG RIG FSYGSGLAA+ +S +V+QDA PGS LDK+ +S DL RL SR V+P+ F Sbjct: 401 ELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEF 460 Query: 424 AENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRP 470 E M RE +H VN+ P G +SLF GTWYL RVDE+HRR YARRP Sbjct: 461 TEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRP 507 >gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] Length = 4588 Score = 30.4 bits (67), Expect = 4.1 Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 1/60 (1%) Query: 382 TLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIP 441 TLYS + +D PG + +I+A+ D++S + T AE KL DT L P Sbjct: 3026 TLYSDTIPEDVLPGKLIMQISATDADIRSNAEI-TYTLLGSGAEKFKLNPDTGELKTSTP 3084 >gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo sapiens] Length = 805 Score = 29.6 bits (65), Expect = 7.0 Identities = 18/68 (26%), Positives = 27/68 (39%), Gaps = 7/68 (10%) Query: 450 EGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPS-------PAKKVPR 502 E W V HR + RR + D+ D G+G S+ +H S P++ + Sbjct: 37 ESLWQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLIT 96 Query: 503 LPATAAEP 510 LP P Sbjct: 97 LPTAHVMP 104 >gi|87196347 zinc finger, B-box domain containing [Homo sapiens] Length = 800 Score = 29.6 bits (65), Expect = 7.0 Identities = 31/145 (21%), Positives = 55/145 (37%), Gaps = 27/145 (18%) Query: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFT 254 G H H +D K D L+ C + + + K+ + + + Sbjct: 441 GIHQHHVFDKGKRDFLN------------------------LCLRNSSTYYKDNSKAETS 476 Query: 255 LNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314 DF ++ Y ++K L ++N S ++ ++ +DT RD Sbjct: 477 NTDFDNIVDPDVYSSDIEKIEESTSFERNLKEKNIGLESNQKSDDSCVSLESKDTLLGRD 536 Query: 315 VEKAFMKASSELFSQKTKASLLVSN 339 +EKA ++ E SQ K SL +SN Sbjct: 537 LEKAPIE---EKLSQDIKESLELSN 558 >gi|109715849 chromosome 6 open reading frame 204 isoform b [Homo sapiens] Length = 496 Score = 29.6 bits (65), Expect = 7.0 Identities = 18/68 (26%), Positives = 27/68 (39%), Gaps = 7/68 (10%) Query: 450 EGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPS-------PAKKVPR 502 E W V HR + RR + D+ D G+G S+ +H S P++ + Sbjct: 37 ESLWQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLIT 96 Query: 503 LPATAAEP 510 LP P Sbjct: 97 LPTAHVMP 104 >gi|226246608 RNA polymerase II associated protein 2 [Homo sapiens] Length = 612 Score = 29.3 bits (64), Expect = 9.1 Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 1/74 (1%) Query: 269 KLVQKSLARMLLNDFLNDQNRDKN-SIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELF 327 +L QKS+ + N +++DK ++ E GD KL+ D E K +++ Sbjct: 241 QLHQKSIMKKKAGHKANSKHKDKEQTVVDVTEQLGDCKLDSQEKDATCELPLQKVNTQSS 300 Query: 328 SQKTKASLLVSNQN 341 S T L +++N Sbjct: 301 SNSTLPERLKASEN 314 >gi|27886520 nuclear factor of activated T-cells 5 isoform a [Homo sapiens] Length = 1455 Score = 29.3 bits (64), Expect = 9.1 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 284 LNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGN 343 L++Q + + +E+ + +E + + +A + SELF A NGN Sbjct: 800 LSNQQQQQQQQQQVMESSAAMVME---MQQSICQAAAQIQSELFPSTASA-------NGN 849 Query: 344 MYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD-ATPGSALDKIT 402 + S VY + +++ S + + +FS ++ S TQ ATPG+ + + + Sbjct: 850 LQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTS 909 Query: 403 AS 404 +S Sbjct: 910 SS 911 >gi|5729945 nuclear factor of activated T-cells 5 isoform c [Homo sapiens] Length = 1531 Score = 29.3 bits (64), Expect = 9.1 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 284 LNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGN 343 L++Q + + +E+ + +E + + +A + SELF A NGN Sbjct: 876 LSNQQQQQQQQQQVMESSAAMVME---MQQSICQAAAQIQSELFPSTASA-------NGN 925 Query: 344 MYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD-ATPGSALDKIT 402 + S VY + +++ S + + +FS ++ S TQ ATPG+ + + + Sbjct: 926 LQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTS 985 Query: 403 AS 404 +S Sbjct: 986 SS 987 >gi|164419746 nuclear factor of activated T-cells 5 isoform d [Homo sapiens] Length = 1548 Score = 29.3 bits (64), Expect = 9.1 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 284 LNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGN 343 L++Q + + +E+ + +E + + +A + SELF A NGN Sbjct: 893 LSNQQQQQQQQQQVMESSAAMVME---MQQSICQAAAQIQSELFPSTASA-------NGN 942 Query: 344 MYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD-ATPGSALDKIT 402 + S VY + +++ S + + +FS ++ S TQ ATPG+ + + + Sbjct: 943 LQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTS 1002 Query: 403 AS 404 +S Sbjct: 1003 SS 1004 >gi|164419744 nuclear factor of activated T-cells 5 isoform b [Homo sapiens] Length = 1549 Score = 29.3 bits (64), Expect = 9.1 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 284 LNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGN 343 L++Q + + +E+ + +E + + +A + SELF A NGN Sbjct: 894 LSNQQQQQQQQQQVMESSAAMVME---MQQSICQAAAQIQSELFPSTASA-------NGN 943 Query: 344 MYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD-ATPGSALDKIT 402 + S VY + +++ S + + +FS ++ S TQ ATPG+ + + + Sbjct: 944 LQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTS 1003 Query: 403 AS 404 +S Sbjct: 1004 SS 1005 >gi|27886524 nuclear factor of activated T-cells 5 isoform a [Homo sapiens] Length = 1455 Score = 29.3 bits (64), Expect = 9.1 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 284 LNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGN 343 L++Q + + +E+ + +E + + +A + SELF A NGN Sbjct: 800 LSNQQQQQQQQQQVMESSAAMVME---MQQSICQAAAQIQSELFPSTASA-------NGN 849 Query: 344 MYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD-ATPGSALDKIT 402 + S VY + +++ S + + +FS ++ S TQ ATPG+ + + + Sbjct: 850 LQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTS 909 Query: 403 AS 404 +S Sbjct: 910 SS 911 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,103,970 Number of Sequences: 37866 Number of extensions: 841686 Number of successful extensions: 1816 Number of sequences better than 10.0: 13 Number of HSP's better than 10.0 without gapping: 3 Number of HSP's successfully gapped in prelim test: 10 Number of HSP's that attempted gapping in prelim test: 1813 Number of HSP's gapped (non-prelim): 13 length of query: 520 length of database: 18,247,518 effective HSP length: 107 effective length of query: 413 effective length of database: 14,195,856 effective search space: 5862888528 effective search space used: 5862888528 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.