Search of human proteins with 14702162

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14702162 CAP-GLY domain containing linker protein 2 isoform
2 [Homo sapiens]
         (1011 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2...  1956   0.0  
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ...  1939   0.0  
gi|38044112 restin isoform b [Homo sapiens]                           788   0.0  
gi|4506751 restin isoform a [Homo sapiens]                            770   0.0  
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap...   171   2e-42
gi|31982881 CAP-GLY domain containing linker protein family, mem...   149   2e-35
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   116   9e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   115   2e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   115   2e-25
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   115   2e-25
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   115   2e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   115   2e-25
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   115   2e-25
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   115   2e-25
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   112   2e-24
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   111   4e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   110   5e-24
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   110   9e-24
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                      110   9e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   109   1e-23
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   108   2e-23
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      107   6e-23
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        105   2e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    103   8e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   103   1e-21
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                       102   1e-21
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                101   4e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       100   7e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       100   7e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        100   7e-21

>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
            [Homo sapiens]
          Length = 1011

 Score = 1956 bits (5068), Expect = 0.0
 Identities = 1011/1011 (100%), Positives = 1011/1011 (100%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA
Sbjct: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
            PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN
Sbjct: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180
            DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL
Sbjct: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180

Query: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240
            TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE
Sbjct: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240

Query: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300
            TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK
Sbjct: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300

Query: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360
            TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA
Sbjct: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL
Sbjct: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLR 480
            VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLR
Sbjct: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLR 480

Query: 481  RGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQ 540
            RGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQ
Sbjct: 481  RGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQ 540

Query: 541  AEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATL 600
            AEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATL
Sbjct: 541  AEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATL 600

Query: 601  NSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEE 660
            NSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEE
Sbjct: 601  NSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEE 660

Query: 661  LAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQ 720
            LAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQ
Sbjct: 661  LAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQ 720

Query: 721  ISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDIS 780
            ISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDIS
Sbjct: 721  ISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDIS 780

Query: 781  EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 840
            EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR
Sbjct: 781  EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 840

Query: 841  RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 900
            RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH
Sbjct: 841  RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 900

Query: 901  KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTED 960
            KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTED
Sbjct: 901  KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTED 960

Query: 961  ALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH 1011
            ALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH
Sbjct: 961  ALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH 1011


>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
            [Homo sapiens]
          Length = 1046

 Score = 1939 bits (5022), Expect = 0.0
 Identities = 1011/1046 (96%), Positives = 1011/1046 (96%), Gaps = 35/1046 (3%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA
Sbjct: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
            PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN
Sbjct: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180
            DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL
Sbjct: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180

Query: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240
            TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE
Sbjct: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240

Query: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300
            TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK
Sbjct: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300

Query: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360
            TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA
Sbjct: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL
Sbjct: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE-------------------- 460
            VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE                    
Sbjct: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE 480

Query: 461  ---------------LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 505
                           LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA
Sbjct: 481  KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 540

Query: 506  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 565
            EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ
Sbjct: 541  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600

Query: 566  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 625
            QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH
Sbjct: 601  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 660

Query: 626  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 685
            QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE
Sbjct: 661  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 720

Query: 686  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 745
            AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV
Sbjct: 721  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 780

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 805
            ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT
Sbjct: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 840

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
            ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ
Sbjct: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
            ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL
Sbjct: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960

Query: 926  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 985
            DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK
Sbjct: 961  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 1020

Query: 986  AQTIGNSGSANGIHQQDKAQKQEDKH 1011
            AQTIGNSGSANGIHQQDKAQKQEDKH
Sbjct: 1021 AQTIGNSGSANGIHQQDKAQKQEDKH 1046


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  788 bits (2034), Expect = 0.0
 Identities = 459/1080 (42%), Positives = 671/1080 (62%), Gaps = 96/1080 (8%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            M KPSGLK P +  K  S   +T T       AV A  ++     K SS PSS       
Sbjct: 3    MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
                     E  ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 49   ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
            DG+V GVRYF+C  L+GIFTRPSKLTR+  AE   +   +  +  A +    S  S  ++
Sbjct: 100  DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159

Query: 178  PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
             P T   IP + S            +++  KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 160  SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219

Query: 227  VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
            VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV 
Sbjct: 220  VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279

Query: 287  RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
            +IGFPST+PAKAK     + MA   ++L  SPS+SS+SS+SSVASSV  RPSR+GLLTET
Sbjct: 280  KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL +  H
Sbjct: 340  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
            +Q+V E E K+ + R +VE+  +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE+ T
Sbjct: 400  DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVAT 459

Query: 464  VAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILR----LRERLLSASK 519
            V+EKSR+++LE++L LR  E+ EL++  L S  P  D   +  +L+    L+E+L     
Sbjct: 460  VSEKSRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 518

Query: 520  EHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWK 579
            +HQRE   L++ +    + +Q E+  L  A EK ++E   LK K++ A  EN  ++  WK
Sbjct: 519  DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578

Query: 580  SKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLE 639
            SKL++  + HQ+++E+LK + + G G +  E  ELK  +E +++++Q E+ NLQ + D E
Sbjct: 579  SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638

Query: 640  TAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHE 699
             A H KE EALR KL +  +E        R++L+    QH +E+++  ++ ++AE++V E
Sbjct: 639  RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698

Query: 700  LEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRL 759
            LE L  +   Q + I+    Q+   E+K+LD + L++A ++GK E++ LR++L  AE ++
Sbjct: 699  LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758

Query: 760  QAV------EALCSSQHTHMIESNDI---------------------------------S 780
            + +      E+  +S  T  ++  ++                                 S
Sbjct: 759  KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818

Query: 781  EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 840
            EE +  + +++   +KL++++++   L+S  E LR  ++ +E+K +  +++ + L+K K 
Sbjct: 819  EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878

Query: 841  RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 900
            +LE ++  + + + D S QL  ++ EL  KER + EL++ L +AN ++   ++ +     
Sbjct: 879  KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938

Query: 901  KAEWRIKE--QKLKDDIRGLREKLTGLDKEKSLSDQR------RYSLIDPSSAPE----L 948
            KAE   +E  +K +++ + L  KL+ L+K+   S  +      RY      +  +    L
Sbjct: 939  KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 998

Query: 949  LRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1008
              LQ  L+ TED L+ A ++   + + +E +R   DKA+    +  A  I +Q   +K E
Sbjct: 999  QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 64/411 (15%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRA 417
            QEA K+ ++  ++L  ER L   E    TSH      +   LKA++E+  +E + K +  
Sbjct: 945  QEAAKKHEEEKKEL--ERKLSDLEKKMETSH-----NQCQELKARYERATSETKTKHEE- 996

Query: 418  RLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEEL 477
              ++++++K  +D  ++L+  R +   L   +EE        +    AE +  +Q+ E++
Sbjct: 997  --ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQM 1052

Query: 478  TLRRGE----IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 533
            T  + E    +E+ +Q          +     E+  L+E  L   +E  +   +L  + +
Sbjct: 1053 TKEKTETLASLEDTKQT---------NAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1103

Query: 534  KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSL 593
            K ++ ++ E++ L+ A  + +Q+++ L++       EN+ L +      D + S HQK L
Sbjct: 1104 K-MEEFRKEIETLKQAAAQKSQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-L 1153

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREK 653
            E+ ++ LN+       ++ E+K        +   E  +LQ    + +A+ + EK+A  EK
Sbjct: 1154 EEERSVLNN-------QLLEMKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEK 1205

Query: 654  LQEAQEELAG-----------LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
            L+     L G           +Q     +++++     LELQ  +++R+ +    +   +
Sbjct: 1206 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1265

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 753
             D + R Q   I+FL   I            LQR     K +VE + E  L
Sbjct: 1266 ADEDERAQESQIDFLNSVI----------VDLQRKNQDLKMKVEMMSEAAL 1306


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  770 bits (1988), Expect = 0.0
 Identities = 459/1115 (41%), Positives = 671/1115 (60%), Gaps = 131/1115 (11%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            M KPSGLK P +  K  S   +T T       AV A  ++     K SS PSS       
Sbjct: 3    MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
                     E  ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 49   ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
            DG+V GVRYF+C  L+GIFTRPSKLTR+  AE   +   +  +  A +    S  S  ++
Sbjct: 100  DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159

Query: 178  PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
             P T   IP + S            +++  KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 160  SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219

Query: 227  VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
            VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV 
Sbjct: 220  VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279

Query: 287  RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
            +IGFPST+PAKAK     + MA   ++L  SPS+SS+SS+SSVASSV  RPSR+GLLTET
Sbjct: 280  KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL +  H
Sbjct: 340  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE--- 460
            +Q+V E E K+ + R +VE+  +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE   
Sbjct: 400  DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT 459

Query: 461  --------------------------------LTTVAEKSRVLQLEEELTLRRGEIEELQ 488
                                            + TV+EKSR+++LE++L LR  E+ EL+
Sbjct: 460  KLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELR 519

Query: 489  QCLLHSGPPPPDHPDAAEILR----LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 544
            +  L S  P  D   +  +L+    L+E+L     +HQRE   L++ +    + +Q E+ 
Sbjct: 520  R-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578

Query: 545  KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGP 604
             L  A EK ++E   LK K++ A  EN  ++  WKSKL++  + HQ+++E+LK + + G 
Sbjct: 579  ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638

Query: 605  GAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGL 664
            G +  E  ELK  +E +++++Q E+ NLQ + D E A H KE EALR KL +  +E    
Sbjct: 639  GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698

Query: 665  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 724
                R++L+    QH +E+++  ++ ++AE++V ELE L  +   Q + I+    Q+   
Sbjct: 699  LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758

Query: 725  EKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESND 778
            E+K+LD + L++A ++GK E++ LR++L  AE +++ +      E+  +S  T  ++  +
Sbjct: 759  EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818

Query: 779  I---------------------------------SEETIRTKETVEGLQDKLNKRDKEVT 805
            +                                 SEE +  + +++   +KL++++++  
Sbjct: 819  LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 878

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             L+S  E LR  ++ +E+K +  +++ + L+K K +LE ++  + + + D S QL  ++ 
Sbjct: 879  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLT 923
            EL  KER + EL++ L +AN ++   ++ +     KAE   +E  +K +++ + L  KL+
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998

Query: 924  GLDKEKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVE 973
             L+K+   S  +      RY      +  +    L  LQ  L+ TED L+ A ++   + 
Sbjct: 999  DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1058

Query: 974  KLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1008
            + +E +R   DKA+    +  A  I +Q   +K E
Sbjct: 1059 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 150/746 (20%), Positives = 309/746 (41%), Gaps = 124/746 (16%)

Query: 296  AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT 355
            +K +   +    V AL  S   ++I+S       +    S+ GL TET+     K    T
Sbjct: 596  SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-GLGTETAEFAELK----T 650

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
             +++   + Q  IE L  ++D ERA  AK          E+  L+A+  + + E E  L+
Sbjct: 651  QIEKMRLDYQHEIENLQNQQDSERAAHAK----------EMEALRAKLMKVIKEKENSLE 700

Query: 416  RARLLVESVRKEKV----DLSNQLEEERRKVEDL---QFRVEEESITKGDLELTTVAEKS 468
              R  ++    + +    D  N+L+E   KV++L   Q +  E++    +      A + 
Sbjct: 701  AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 760

Query: 469  RVLQLE---EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRES 525
            ++L L+   +  +  + E+++L+Q L           +AAE  +++   +  + E  + S
Sbjct: 761  KLLDLDALRKASSEGKSEMKKLRQQL-----------EAAE-KQIKHLEIEKNAESSKAS 808

Query: 526  GVLRDKYEKALKA--YQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 583
             + R+   + LK    Q  + ++    E   +E+  LK+K  +A+ E + +  + +  ++
Sbjct: 809  SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868

Query: 584  SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMH 643
             L   HQK                +++   L + +E ++      L +++AK        
Sbjct: 869  KL---HQK----------------EEQFNMLSSDLEKLREN----LADMEAKF------- 898

Query: 644  VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 703
             +EK+   E+L +A+E+L     +  A++   +  +  +L +  D+ R   L+  ++E+L
Sbjct: 899  -REKDEREEQLIKAKEKL----ENDIAEIMKMSGDNSSQLTKMNDELR---LKERDVEEL 950

Query: 704  DVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVE 763
             ++     +   FL++  S+ +  +   +  Q A  + ++E + L  KL   E +++   
Sbjct: 951  QLKLTKANENASFLQK--SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008

Query: 764  ALCSSQHTHMIESNDISEETIRTKETVEGLQ-------DKLNKRDKEVTALTSQTEMLRA 816
              C         +   SE   + +E ++ LQ       DKL    +E + L  + E LR 
Sbjct: 1009 NQCQELKARYERAT--SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066

Query: 817  QVSALESKCKSGEKKVDAL------LKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
            Q      K K+ +   DA+       KEK    A LE   +       +L  + +  L+ 
Sbjct: 1067 QAD----KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKN 1122

Query: 871  ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--------QKLKDDIRGLREKL 922
               LN+ + LL   N+      +++      A  + ++         KL +++   R+++
Sbjct: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182

Query: 923  TG---LDKEKS------LSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVE 973
            T    L++E+S      L  ++R S     +  E   LQ  +  T   L +   + +++ 
Sbjct: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242

Query: 974  KLMEAMRSCPDKAQTIGNSGSANGIH 999
              +  +R         G + SA  +H
Sbjct: 1243 NEVTVLR---------GENASAKSLH 1259



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 64/411 (15%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRA 417
            QEA K+ ++  ++L  ER L   E    TSH      +   LKA++E+  +E + K +  
Sbjct: 980  QEAAKKHEEEKKEL--ERKLSDLEKKMETSH-----NQCQELKARYERATSETKTKHEE- 1031

Query: 418  RLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEEL 477
              ++++++K  +D  ++L+  R +   L   +EE        +    AE +  +Q+ E++
Sbjct: 1032 --ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQM 1087

Query: 478  TLRRGE----IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 533
            T  + E    +E+ +Q          +     E+  L+E  L   +E  +   +L  + +
Sbjct: 1088 TKEKTETLASLEDTKQT---------NAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1138

Query: 534  KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSL 593
            K ++ ++ E++ L+ A  + +Q+++ L++       EN+ L +      D + S HQK L
Sbjct: 1139 K-MEEFRKEIETLKQAAAQKSQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-L 1188

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREK 653
            E+ ++ LN+       ++ E+K        +   E  +LQ    + +A+ + EK+A  EK
Sbjct: 1189 EEERSVLNN-------QLLEMKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEK 1240

Query: 654  LQEAQEELAG-----------LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
            L+     L G           +Q     +++++     LELQ  +++R+ +    +   +
Sbjct: 1241 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 753
             D + R Q   I+FL   I            LQR     K +VE + E  L
Sbjct: 1301 ADEDERAQESQIDFLNSVI----------VDLQRKNQDLKMKVEMMSEAAL 1341


>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
           sapiens]
          Length = 547

 Score =  171 bits (434), Expect = 2e-42
 Identities = 97/230 (42%), Positives = 134/230 (58%), Gaps = 23/230 (10%)

Query: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140
           +G+RV ++G K G +++ G T+FA GQW GV LD+P GKNDG+VGGVRYF CP  QG+F 
Sbjct: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355

Query: 141 RPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGN 200
             SK+++   A  S                  S T+TP  T R+   R +        G 
Sbjct: 356 SVSKISKAVDAPPS------------------SVTSTPR-TPRMDFSRVTGKGRREHKGK 396

Query: 201 ESGSNLSDSGSVK-RGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGK 259
           +   +    GS++ R      +GD+VLV G K G+VR+ G+TDFA G W G+ELD+P GK
Sbjct: 397 KKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGK 456

Query: 260 NDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK---AKKTKRMAM 306
           +DG+V G RYF CPP+ G+FAP  ++ RIG  + SP     AKK  ++ M
Sbjct: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTM 506



 Score =  106 bits (265), Expect = 1e-22
 Identities = 58/124 (46%), Positives = 75/124 (60%), Gaps = 10/124 (8%)

Query: 210 GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 269
           G++      LRLGDRVL+ G KTG +R+ G T+FA G+W GVELDEP GKNDG+V G RY
Sbjct: 285 GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRY 344

Query: 270 FQCPPKFGLFAPIHKVIR-IGFPSTSPAKAKKTKRM----AMGVSALTH-----SPSSSS 319
           F CPPK GLFA + K+ + +  P +S     +T RM      G     H     +PSS S
Sbjct: 345 FICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPS 404

Query: 320 ISSV 323
           + S+
Sbjct: 405 LGSL 408



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 11/152 (7%)

Query: 40  EGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLG 99
           +G   HK      SSP+  +  ++ G KA            VG++V V G K G+V++ G
Sbjct: 388 KGRREHKGKKKTPSSPSLGSLQQRDGAKAE-----------VGDQVLVAGQKQGIVRFYG 436

Query: 100 ETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAH 159
           +T FAPG W G+ LD P GK+DG+V GVRYF CP   G+F   S++ R   +  S  D+ 
Sbjct: 437 KTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSV 496

Query: 160 SVESLTAQNLSLHSGTATPPLTSRVIPLRESV 191
             + +    ++    T T   T + I    S+
Sbjct: 497 GAKKVHQVTMTQPKRTFTTVRTPKDIASENSI 528


>gi|31982881 CAP-GLY domain containing linker protein family, member
           4 [Homo sapiens]
          Length = 705

 Score =  149 bits (375), Expect = 2e-35
 Identities = 105/344 (30%), Positives = 163/344 (47%), Gaps = 68/344 (19%)

Query: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140
           +G+RV + G K G +++ G T+FA GQWAG+ LD+P GKN+G+VG V+YF+C    GIF 
Sbjct: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344

Query: 141 RPSKL----------TRQPTAEGS--------------------GSDAHSVESLTAQNLS 170
             SK+          T  P+ + +                    G      +S +   LS
Sbjct: 345 PLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLS 404

Query: 171 LHSGTATPPLTSRVI---------------------PLRESVLNSSVKTGNES------- 202
           L  G     +T + +                     P +++ ++S+ KT ++S       
Sbjct: 405 LPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRA 464

Query: 203 ----GSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLG 258
                S+ + + +  R E +LRLG+RVLV G + G +R+ G T+FA G W G+EL++P G
Sbjct: 465 SAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHG 524

Query: 259 KNDGAVAGTRYFQCPPKFGLFAPIHKVIRI--GFPSTSPAKAKKTKRMAMGVSALTHSPS 316
           KNDG+V G +YF C P++G+FAP  +V R+     + S   + K      G      S S
Sbjct: 525 KNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPG---FRRSFS 581

Query: 317 SSSISSVSSVASSVGGRPSRSGLLTETSSR-YARKISGTTALQE 359
           ++S SS   +        S++ L    SS   A  I G+  L E
Sbjct: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHE 625



 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/283 (33%), Positives = 134/283 (47%), Gaps = 18/283 (6%)

Query: 9   PPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKA 68
           PPG   K  +       GS SS ++ ++     S   KQ++  S+    + +P      +
Sbjct: 406 PPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRAS 465

Query: 69  AEVGDDFL---------GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGK 119
           A +              G+  +GERV V G + G +++ G T FAPG W G+ L+ P GK
Sbjct: 466 AGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK 525

Query: 120 NDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLS---LHSGTA 176
           NDG+VGGV+YF C    GIF  PS++ R         D  S  S   QN S        +
Sbjct: 526 NDGSVGGVQYFSCSPRYGIFAPPSRVQRVT----DSLDTLSEISSNKQNHSYPGFRRSFS 581

Query: 177 TPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLV-GGTKTGVV 235
           T   +S+    R +  + S      S S+   +G ++ G   L  G +VL+    + G V
Sbjct: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIE-GSVKLHEGSQVLLTSSNEMGTV 640

Query: 236 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278
           RYVG TDFA G W G+EL    GKNDG+V   RYF C P  G+
Sbjct: 641 RYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGV 683



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 44/101 (43%), Positives = 66/101 (65%), Gaps = 16/101 (15%)

Query: 219 LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278
           L+LGDRV++ G K G +R+ G T+FA G+W G+ELDEP GKN+G+V   +YF+C PK+G+
Sbjct: 283 LKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGI 342

Query: 279 FAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSS 319
           FAP+ K+        S AK ++          +TH+PS+ +
Sbjct: 343 FAPLSKI--------SKAKGRRKN--------ITHTPSTKA 367



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 27/54 (50%), Positives = 34/54 (62%)

Query: 93  GVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLT 146
           G V+Y+G T FA G W G+ L    GKNDG+VG  RYF C    G+  RPS++T
Sbjct: 638 GTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVT 691


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  116 bits (291), Expect = 9e-26
 Identities = 161/700 (23%), Positives = 277/700 (39%), Gaps = 94/700 (13%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     ++  T  ++AL+E  Q   Q L +   E   V+  T     +E+++  L
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQ---QALGDLQAEEDRVSALTKAKLRLEQQVEDL 1083

Query: 400  KAQHEQY------VAEAEEKLQR-ARLLVESVR---KEKVDLSNQLEEERRKVEDLQFRV 449
            +   EQ          A+ KL+   +L  ESV    ++K  L  +L+++  ++  L  RV
Sbjct: 1084 ECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRV 1143

Query: 450  EEESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSG 495
            E+E +    ++      ++R  +LEEEL   R               E+EEL + L  +G
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG 1203

Query: 496  PPPPDHPDA-----AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAAN 550
                   +      AE+ RLR  L  A+  H+     LR K  +       +VD L+   
Sbjct: 1204 GASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVR 1263

Query: 551  EKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLK----------ATL 600
            +K  +E + L+ +V    + N+  +   K+  + L   ++  L + K          A  
Sbjct: 1264 QKLEKEKSELRMEVDDLAA-NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADA 1322

Query: 601  NSGPGAQQKEIGELKAVMEGIK-MEHQLELGNLQAKHDLETAMHVKEKEA---------- 649
            ++  G  Q E GEL  ++E  + +  QL  G   A   LE      E+E+          
Sbjct: 1323 STQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAV 1382

Query: 650  ---------LREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQDQR 690
                     LRE+ +E  E  A LQR           WR++ E  A Q   EL+EA   +
Sbjct: 1383 QALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA---K 1439

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQISL-AEKKMLDYERLQRAEAQGKQEVESLR 749
            +   LR+ E E+       +  ++E  K ++   +E   L+ ER   A A   ++   L 
Sbjct: 1440 KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTS 809
              L   E R +  E +         ES  +  E  R +   E   + L         L  
Sbjct: 1500 RAL---EERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE-------TLKR 1549

Query: 810  QTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 869
            + + L+ ++S L  +     K +  L K K+ LE E   +     +A G L L   + LR
Sbjct: 1550 ENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLR 1609

Query: 870  KERSLNELRV----LLLEANRHSPGPERDLSREVHKAEWRI-KEQKLKDDIRGLREKLTG 924
             +  L++++      L E +       R+  R V   +  +  E + +++   L++K+ G
Sbjct: 1610 IQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEG 1669

Query: 925  LDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRD 964
                  L  Q  ++    + A    RL    +  E A RD
Sbjct: 1670 --DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRD 1707



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 150/651 (23%), Positives = 279/651 (42%), Gaps = 88/651 (13%)

Query: 391  EVEKEIALLKAQHEQY---VAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVED--- 444
            + E+E+A L+A+       +A AE K Q       S+ +EK DL+ QL+ E+  + D   
Sbjct: 893  QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952

Query: 445  -----------LQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLH 493
                       L+ +V+E S    D E       +R  +LE+E T  + +I++L+  L  
Sbjct: 953  RCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAK 1012

Query: 494  SGPPPPDHPDAAEILRLRERLLSASKEHQR---ESGVLRDKYEKALKAYQAEVDKLRA-- 548
            +           ++  L E + +  +   R   E   L++ +++AL   QAE D++ A  
Sbjct: 1013 A--EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070

Query: 549  -ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD-----------SLASDHQKSLEDL 596
             A  +  Q+V  L+  ++Q     M   +  K KL+             A D Q+  E L
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMD-TERAKRKLEGDLKLTQESVADAAQDKQQLEEKL 1129

Query: 597  KATLNSGP------------GAQ-QKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMH 643
            K   +               GAQ QK+I EL+A  E ++ E + E    +A+ + + A  
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA-ARARVEKQRAEA 1188

Query: 644  VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEA--QDQRRDAELRVHELE 701
             +E E L E+L+EA    AG QR    + E +  + R EL+EA  + +   A LR     
Sbjct: 1189 ARELEELSERLEEAGGASAG-QREGCRKREAELGRLRRELEEAALRHEATVAALR----- 1242

Query: 702  KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQA 761
                  R QA+    L EQ+   ++     ++L++ +++ + EV+ L   +        +
Sbjct: 1243 ------RKQAEGAAELGEQVDSLQRVR---QKLEKEKSELRMEVDDLAANVETLTRAKAS 1293

Query: 762  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 821
             E LC +    + E+    EE  R        + +L     E++ L  + E L +Q+S  
Sbjct: 1294 AEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRG 1353

Query: 822  ESKCKSGEKKVDALLKEKRRLEAEL-ETVSRKTHDASGQLVLISQELLRKERSLNELRVL 880
            ++      +++   L+E+ + ++ L   V    HD      L+ ++   +  +  EL+ L
Sbjct: 1354 KALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCD----LLREQHEEEAEAQAELQRL 1409

Query: 881  LLEANR---------HSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK-- 929
            L +AN           +   +R    E  K +  ++ Q+ ++ +     K + L+K K  
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469

Query: 930  --SLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEA 978
              + S+     L   +SA   L  + + +  E AL +   Q +++++ +EA
Sbjct: 1470 LQTESEDVTLELERATSAAAALDKKQRHL--ERALEERRRQEEEMQRELEA 1518



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 159/677 (23%), Positives = 290/677 (42%), Gaps = 118/677 (17%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQL-----LAERDLERA-----EVAKATSHI 389
            L + S++  R  + +  L   L+EK+  I QL     LA + LE       E +KA S +
Sbjct: 1319 LADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSAL 1378

Query: 390  CEVEKEIA----LLKAQHEQYVAEAEEKLQR----ARLLVESVRK----EKVDLSNQLEE 437
                + +     LL+ QHE+  AEA+ +LQR    A   V   R     + +  + +LEE
Sbjct: 1379 AHAVQALRHDCDLLREQHEEE-AEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEE 1437

Query: 438  ERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLE-EELTLRRGEIEELQQCLLHSGP 496
             ++K+  L+ +  EE +   + + +++ +    LQ E E++TL   E+E           
Sbjct: 1438 AKKKLA-LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTL---ELERATSAAAALDK 1493

Query: 497  PPPDHPDAAEILRLRE----RLLSASKEHQRESGV----LRDKYEKALKAYQAEVDKLRA 548
                   A E  R +E    R L A++   R  G     LR  +E+AL+A    ++ L+ 
Sbjct: 1494 KQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEA----LETLKR 1549

Query: 549  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQ- 607
             N+   +E++ L D+V   + +++  ++  K  L+   S+ Q +LE+ +  L        
Sbjct: 1550 ENKNLQEEISDLTDQVS-LSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608

Query: 608  --QKEIGELKAVME-----------GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKL 654
              Q E+ ++KA ++            ++  HQ  + +LQA  D ET     E   L++K+
Sbjct: 1609 RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRAR-NEALRLKKKM 1667

Query: 655  QEAQEELAGLQRH-WRAQLEVQASQHRLELQEAQDQR-RDAELRVHELEKLDVEYRGQAQ 712
            +    +L     H  R   E QA+   ++ Q  ++Q  RD E      ++L  E   QAQ
Sbjct: 1668 EGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE------QRLAAELHEQAQ 1721

Query: 713  AIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTH 772
            A+E    + SL   ++   E L+ A  QG++      ++LL A  RL     L  SQ+T 
Sbjct: 1722 ALE---RRASLLAAEL---EELRAALEQGERSRRLAEQELLEATERLN----LLHSQNTG 1771

Query: 773  MIESN-----DISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVS-------- 819
            ++        D+++ +   +E  +  ++   K  K +T      E L+ +          
Sbjct: 1772 LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1831

Query: 820  -----------------ALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVL 862
                             A ++  + G+K+V  L  + R LEAEL+   +K  +A      
Sbjct: 1832 KKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEA------ 1885

Query: 863  ISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV------HKAEWRIKEQKLKDDIR 916
              + + + ER + EL     E +R +    +DL  ++      +K ++   EQ+   ++ 
Sbjct: 1886 -LKGVRKHERRVKEL-AYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943

Query: 917  GLREKLTGLDKEKSLSD 933
              R+    LD  +  +D
Sbjct: 1944 KYRKAQHELDDAEERAD 1960



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 70/307 (22%), Positives = 139/307 (45%), Gaps = 23/307 (7%)

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLE---VQASQHR----LELQEAQDQR 690
            L +A   +E  ALR +L+  +  LA  +   R +LE   V  +Q +    L+LQ  QD  
Sbjct: 889  LRSAQAEEELAALRAELRGLRGALAAAEAK-RQELEETHVSITQEKNDLALQLQAEQDNL 947

Query: 691  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 749
             DAE R H L K  V+  G+ + + E L+++  +         +L+    + K++++ L+
Sbjct: 948  ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLK 1007

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDK----LNKRDKEVT 805
              L  AE   QA E    +    M   ++      + K+ ++    +    L   +  V+
Sbjct: 1008 LTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVS 1067

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
            ALT     L  QV  LE   +  +K      + KR+LE +L+       DA+     + +
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHK--AEWRIKEQKLKDDIRGLREKLT 923
            +L +K+  L++L + + +        E+ L  ++ K   E + + ++L++++   R    
Sbjct: 1128 KLKKKDSELSQLSLRVED--------EQLLGAQMQKKIKELQARAEELEEELEAERAARA 1179

Query: 924  GLDKEKS 930
             ++K+++
Sbjct: 1180 RVEKQRA 1186


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  115 bits (289), Expect = 2e-25
 Identities = 148/662 (22%), Positives = 280/662 (42%), Gaps = 62/662 (9%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL 414
            T ++  L+E ++  +QLL E+++   ++   T    E E+  A L A+ +    E EE L
Sbjct: 869  TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ----ELEEIL 924

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLE 474
                  VE   +    L N+ ++ +  ++DL+ +++EE   +  L+L  V  ++++ ++E
Sbjct: 925  HDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME 984

Query: 475  EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEK 534
            EE+ L    +E+     +       D    AE        L+  +E  +    +R+K E 
Sbjct: 985  EEILL----LEDQNSKFIKEKKLMEDR--IAEC----SSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 535  ALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 594
             +   +  + K     EK  QE+   K K+   T++    +   ++++D L     K  E
Sbjct: 1035 MISDLEERLKK----EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090

Query: 595  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKL 654
            +L+  L  G      +   LK V      E Q ++  LQ   + E A   K ++  R   
Sbjct: 1091 ELQGALARGDDETLHKNNALKVV-----RELQAQIAELQEDFESEKASRNKAEKQKR--- 1142

Query: 655  QEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-----QRRDAELRVHELEKLDVEYRG 709
             +  EEL  L+      L+  A+Q  L  +  Q+     +  + E + HE +  D+  R 
Sbjct: 1143 -DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR- 1200

Query: 710  QAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQ 769
             A A+E L EQ+  A++   + E+        KQ +E+  ++L      LQ V+A   S+
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEK-------NKQGLETDNKELACEVKVLQQVKA--ESE 1251

Query: 770  HTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 829
            H              +    V+ L  K+++ D+    L  +   L+ ++  + +  +  E
Sbjct: 1252 HKRK-----------KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300

Query: 830  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 889
            KK     K+   LE++L+       + + Q + +S  + + E   N L+    E      
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ----EQQEEEE 1356

Query: 890  GPERDLSREVHKAEWRIKEQKLK-DDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSA--- 945
               ++L ++V   + ++ + K K DD  G  E L    K+K L D    S      A   
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA-KKKLLKDAEALSQRLEEKALAY 1415

Query: 946  PELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQ 1005
             +L + +++L    D L   LD  +QV   +E  +   D+      S SA    ++D+A+
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 1006 KQ 1007
             +
Sbjct: 1476 AE 1477



 Score =  102 bits (254), Expect = 2e-21
 Identities = 168/731 (22%), Positives = 304/731 (41%), Gaps = 113/731 (15%)

Query: 339  LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI-- 396
            L  E     AR  +    L+E L + +  +E+      + + E  K  +HI ++E+++  
Sbjct: 902  LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961

Query: 397  ---ALLKAQHEQYVAEAE-EKLQRARLLVESVR----KEK-------VDLSNQLEEERRK 441
               A  K Q E+  AEA+ +K++   LL+E       KEK        + S+QL EE  K
Sbjct: 962  EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 442  --------------VEDLQFRVEEESITKGDL---------ELTTVAEKSRVLQLE-EEL 477
                          + DL+ R+++E  T+ +L         E T + ++   LQ + +EL
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081

Query: 478  TLRRGEIEELQQCLLHSGPPPPDHP-DAAEILRLRERLLSASKEHQRESGVLRDKYEKAL 536
             L+  + EE  Q  L  G     H  +A +++R  +  ++  +E        R+K EK  
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141

Query: 537  KAYQAEVDKLRAANE--------------KYAQEVAGLKDKVQQATSENMGLMDNWKSKL 582
            +    E++ L+   E              K  QEVA LK  +++ T        N ++++
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-------NHEAQI 1194

Query: 583  DSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAM 642
              +   H  +LE+L          Q ++    KA +E  K +  LE  N +   +++   
Sbjct: 1195 QDMRQRHATALEEL--------SEQLEQAKRFKANLE--KNKQGLETDNKELACEVKVLQ 1244

Query: 643  HVK-EKEALREKLQEAQEEL-AGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHEL 700
             VK E E  R+KL    +EL A +    R ++E+     +L     Q++  +    + E 
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL-----QNELDNVSTLLEEA 1299

Query: 701  EKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQ 760
            EK         + I+F K+  SL E ++ D + L + E + K  + S   +L   +N LQ
Sbjct: 1300 EK---------KGIKFAKDAASL-ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349

Query: 761  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSA 820
                    Q        ++ ++ +  +  +   + K++     + +L    + L     A
Sbjct: 1350 ------EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403

Query: 821  LESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL 880
            L  + +      D L K K RL+ EL+ +   T D   Q   ++  L +K++  ++L   
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDL---TVDLDHQR-QVASNLEKKQKKFDQLL-- 1457

Query: 881  LLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
               A   S        R+  +AE R KE K     R L E L   ++ +  + Q R  + 
Sbjct: 1458 ---AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514

Query: 941  D-PSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIH 999
            D  SS  ++ +  H+L  ++ AL       QQVE++   +    D+ Q   ++     ++
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALE------QQVEEMRTQLEELEDELQATEDAKLRLEVN 1568

Query: 1000 QQD-KAQKQED 1009
             Q  KAQ + D
Sbjct: 1569 MQAMKAQFERD 1579



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 121/592 (20%), Positives = 242/592 (40%), Gaps = 95/592 (16%)

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            S R   K      L++     QQ ++ L  + D +R    +  S++ + +K+   L A+ 
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEE 1460

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-----ERRKVEDLQFRVEEESI--TK 456
            +   A   E+  RA         + + L+  LEE     E  + ++ Q R + E +  +K
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520

Query: 457  GDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 516
             D+       +     LE+++   R ++EEL+           D   A E  +LR     
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELE-----------DELQATEDAKLR----- 1564

Query: 517  ASKEHQRESGVLRDKYEKALKAYQAEVDK-LRAANEKYAQEVAGLKDKVQQATSENMGLM 575
                            E  ++A +A+ ++ L+  +E+  ++   L  +V++  +E   L 
Sbjct: 1565 ---------------LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE---LE 1606

Query: 576  DNWKSKLDSLASDHQK--SLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQ 633
            D  K +  ++AS  +    L+DL+A + +   A+ + I +L+ +   +K ++Q EL   +
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK-DYQRELEEAR 1665

Query: 634  AKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE----- 685
            A  D    ++    K+ ++L  ++ + QEELA  +R  R      A Q R EL +     
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR-----HAEQERDELADEITNS 1720

Query: 686  ------AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEA 739
                    D++R  E R+ +LE+   E   +   +E L ++      ++        AE 
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEE---ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 740  QGKQEVESLREKL----LVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD 795
               Q+ ++ R++L       + +LQ +E    S                + K T+  L+ 
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKS----------------KFKATISALEA 1821

Query: 796  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 855
            K+ + ++++     +       V   E K K    +V+   +   + + ++E  + +   
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ 1881

Query: 856  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 907
               QL    +E  R   S  +L+  L +A   + G    LSREV   + R++
Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQRELDDATEANEG----LSREVSTLKNRLR 1929


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  115 bits (288), Expect = 2e-25
 Identities = 161/715 (22%), Positives = 315/715 (44%), Gaps = 117/715 (16%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 872  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLELTTVAEKSRV 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+L  V  ++++
Sbjct: 932  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 471  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERL------LSASKEHQRE 524
             +LE+E+ +   +  +L +                E   L ER+      L+  +E  + 
Sbjct: 981  KKLEDEILVMDDQNNKLSK----------------ERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDS 584
               L++K+E  +   +  + K     EK  QE+  LK K++   S+    + + ++++  
Sbjct: 1025 LTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 585  LASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV 644
            L     K  E+L+A L         EI +    ++ I+ E +  + +LQ   D E A   
Sbjct: 1081 LKMQLAKKEEELQAAL----ARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSERAARN 1135

Query: 645  KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-----QRRDAELRVHE 699
            K ++  R    +  EEL  L+      L+  A+Q  L  +  Q+     +  D E R HE
Sbjct: 1136 KAEKQKR----DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 700  LEKLDVEYRGQAQAIEFLKEQI--------------SLAEKKMLDYERLQRAEAQGKQEV 745
             +  ++  +  AQA+E L EQ+                 EK+  D     R   Q KQEV
Sbjct: 1192 AQVQEMRQK-HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL----QDKLNKRD 801
            E  ++KL   E ++Q +++ CS       E ND   +     E+V G+    + K  K  
Sbjct: 1251 EHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 802  KEVTALTSQ----TEMLR----------AQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
            K+V +L+SQ     E+L+           ++  LE +  S + ++D  ++ K+ LE  + 
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367

Query: 848  TVSRKTHDASGQL--VLISQELLR--KERSLNELRVLLLEANRHSPGPERDLSREVHKAE 903
            T++ +  D+  +L     + E L   K+R   E+  L  +    +   ++     + K +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-----LEKTK 1422

Query: 904  WRIKEQKLKD---DIRGLREKLTGLDKEKSLSDQ---------RRYSLIDPSSAPELLRL 951
             R+ +Q+L D   D+   R+ ++ L+K++   DQ          +Y+     +  E    
Sbjct: 1423 NRL-QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 952  QHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQK 1006
            + + +S   AL +AL+  +++E+  + +++  +   +  +    N +H+ +K+++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKR 1535



 Score =  105 bits (261), Expect = 3e-22
 Identities = 158/695 (22%), Positives = 301/695 (43%), Gaps = 79/695 (11%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            ++  L+E++   +QL AER     ++      +   E+E A  K Q E+  AEA+ K   
Sbjct: 927  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLE 984

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE 476
              +LV   +  K+    +L EER  + DL   + EE     +L       +S + +LE  
Sbjct: 985  DEILVMDDQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042

Query: 477  LTLR---RGEIEELQQCLLHSGPPPPDHPDAAEI-LRLRERLLSASKEHQRESGVLRDKY 532
            L      R E+E+L++ L   G     H   A++  ++ E  +  +K+         ++ 
Sbjct: 1043 LKKEEKSRQELEKLKRKL--EGDASDFHEQIADLQAQIAELKMQLAKK--------EEEL 1092

Query: 533  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 592
            + AL     E+ +   A +K  +    + D  +   SE        ++K +    D  + 
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-----RNKAEKQKRDLGEE 1147

Query: 593  LEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALRE 652
            LE LK  L        ++  +  A  + ++ + + E+  L+   D ET  H  + + +R+
Sbjct: 1148 LEALKTEL--------EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 653  KLQEAQEELA-GLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQA 711
            K  +A EEL   L++  RA+  +  ++  LE + A       ELRV    K +VE++ + 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK 1256

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALC 766
                 L+ Q+   + K  D ER  RAE   K      EVES+   L  AE +   +    
Sbjct: 1257 -----LEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 767  SSQHTHMIESNDISEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLR 815
            +S  + + ++ ++ +E  R K           E    LQD+L++  +    L      L 
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLN 875
             Q+S  + K +     V+AL + K+R + E+E ++++  + +     + +   R ++ L+
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 876  ELRVLL---------LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIR 916
            +L V L         LE  +         E+++S      R+  +AE R KE K     R
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 917  GLREKLTGLDKEKSLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEK 974
             L E L   ++ +  +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 975  LMEAMRSCPD-KAQTIGNSGSANGIHQQDKAQKQE 1008
            L + +++  D K +   N  +  G  ++D   + E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 147/694 (21%), Positives = 286/694 (41%), Gaps = 62/694 (8%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 395  EIALLKAQHEQYVAEAEEKL---QRARL----LVESVRKEKVDLSNQLEEERRKVEDLQF 447
            E+   K + E  V E + K    +RAR      V  ++ E   ++  L E   K   L  
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308

Query: 448  RVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEI 507
             V   S    D +     E  + L +  +L     E   LQ  L        +       
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368

Query: 508  LRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA---QEVAGLKDKV 564
            L ++   LS SK+  ++     +  E+  K +Q E++ L    E+ A    ++   K+++
Sbjct: 1369 LNIQ---LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 565  QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN-SGPGAQQKEIGELKA---VMEG 620
            QQ   + +  +DN +  + +L    +K  + L    N S   A +++  E +A     + 
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 621  IKMEHQLELGNLQAKHDLETA--MHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 678
            + +   LE   L+AK +LE    M   E E L     +  + +  L++  RA LE Q  +
Sbjct: 1486 LSLARALEEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEE 1543

Query: 679  HRLELQEAQDQRR---DAELRVH-ELEKLDVEYRGQAQAIEF--------LKEQISLAEK 726
             + +L+E +D+ +   DA+LR+   ++ L  ++    QA +         L+ Q+   E 
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 727  KMLDYERLQRA-EAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETI 784
            ++ D ER QRA  A  K+++E  L++  L A++ ++  E           +  D   E  
Sbjct: 1604 ELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 785  RTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD----------- 833
              + + + +     + +K+  +L +    L+  ++A E   K  + + +           
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 834  ---ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR----KERSLNELRVLLLEANR 886
               AL  EKRRLEA +  +  +  +  G +  +S  + +     E+  NEL      A +
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 887  HSPGPE------RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
            +    +      ++L  ++H+ E  +K  K K  I  L  K+  L+ E+   + R     
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLE-EQVEQEAREKQAA 1840

Query: 941  DPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
              S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 141/592 (23%), Positives = 255/592 (43%), Gaps = 91/592 (15%)

Query: 324  SSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 383
            S+V +   G+      +   + +Y  K +    L++     QQ ++ L+ + D +R  V+
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 384  ------KATSHICEVEKEIALLKA-QHEQYVAEAEEK----LQRARLLVESVR-KEKVDL 431
                  +    +   EK I+   A + ++  AEA EK    L  AR L E++  KE+++ 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 432  SNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCL 491
            +N++   + ++EDL     ++ + K   EL    EKS+   LE ++   + ++EEL+   
Sbjct: 1505 TNKML--KAEMEDLVS--SKDDVGKNVHEL----EKSK-RALETQMEEMKTQLEELE--- 1552

Query: 492  LHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRESGVLRDKYEKALKAY 539
                    D   A E  +LR            ER L A  E   E    R + ++ L  Y
Sbjct: 1553 --------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK---RRQLQRQLHEY 1601

Query: 540  QAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSL 593
            + E++   K RA      +++ G LKD   QA S   G  +  K   KL +   D Q+ L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK-----EKE 648
            ED +A+        + EI       E  K    LE   +Q + DL  A   +     EKE
Sbjct: 1662 EDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711

Query: 649  ALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
             L E+L  +      LQ   R      AQLE +  + +  ++   D+ R A  +  +L  
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEVESLREKLLVAENRLQ 760
                 R  AQ  E  ++Q+    K++    +E     +++ K  + +L  K+   E +++
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 761  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKEVTALTSQTEMLRAQV 818
              EA      T  ++  D      + KE +  ++D  K+ ++ KE      Q E   A+V
Sbjct: 1832 Q-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE------QAEKGNARV 1879

Query: 819  SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
              L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V   +  LR+
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNALKSKLRR 1930



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 110/510 (21%), Positives = 216/510 (42%), Gaps = 62/510 (12%)

Query: 361  LKEKQQHIEQLLAE-----------RDLERAE----------VAKATSHICEVEKEIA-- 397
            L++KQ+  +QLLAE           RD   AE          +A+A     E ++E+   
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 398  --LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT 455
              +LKA+ E  V+  ++  +     V  + K K  L  Q+EE + ++E+L+  ++     
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 456  KGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLL 515
            K  LE+   A K    Q E +L  R  + EE ++ L         H    E+   R++  
Sbjct: 1562 KLRLEVNMQALKG---QFERDLQARDEQNEEKRRQLQRQL-----HEYETELEDERKQRA 1613

Query: 516  SASKEHQRESGVLRD---KYEKALKAYQAEVDKLRAAN------EKYAQEVAGLKDKVQQ 566
             A+   ++  G L+D   + + A+K  +  + +LR         ++  ++    +D++  
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673

Query: 567  ATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGA--QQKEIGELKAVMEGIKME 624
               EN       + K  SL +D  +  EDL A   +   A  +++E+ E  A     +  
Sbjct: 1674 TAKEN-------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 625  HQLELGNLQAK-HDLETAMHVKE--KEALREKLQEAQEELAGLQRHWRAQLEVQASQHRL 681
             Q E   L+A+   LE  +  ++   EA+ +++++A ++   L      +    A ++  
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST-AQKNES 1785

Query: 682  ELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ 740
              Q+ + Q ++   ++HE+E  +  +++    A+E    Q  L E+   +    Q A   
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEAREKQAATKS 1843

Query: 741  GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKR 800
             KQ+ + L+E LL  E+  +  E               +  +    +E  + +     K 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903

Query: 801  DKEVTALTSQTEMLRAQVSALESKCKSGEK 830
             +E+   T   E +  +V+AL+SK + G +
Sbjct: 1904 QRELDEATESNEAMGREVNALKSKLRRGNE 1933


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  115 bits (288), Expect = 2e-25
 Identities = 161/715 (22%), Positives = 315/715 (44%), Gaps = 117/715 (16%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 879  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLELTTVAEKSRV 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+L  V  ++++
Sbjct: 939  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 471  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERL------LSASKEHQRE 524
             +LE+E+ +   +  +L +                E   L ER+      L+  +E  + 
Sbjct: 988  KKLEDEILVMDDQNNKLSK----------------ERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDS 584
               L++K+E  +   +  + K     EK  QE+  LK K++   S+    + + ++++  
Sbjct: 1032 LTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 585  LASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV 644
            L     K  E+L+A L         EI +    ++ I+ E +  + +LQ   D E A   
Sbjct: 1088 LKMQLAKKEEELQAAL----ARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSERAARN 1142

Query: 645  KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-----QRRDAELRVHE 699
            K ++  R    +  EEL  L+      L+  A+Q  L  +  Q+     +  D E R HE
Sbjct: 1143 KAEKQKR----DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 700  LEKLDVEYRGQAQAIEFLKEQI--------------SLAEKKMLDYERLQRAEAQGKQEV 745
             +  ++  +  AQA+E L EQ+                 EK+  D     R   Q KQEV
Sbjct: 1199 AQVQEMRQK-HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL----QDKLNKRD 801
            E  ++KL   E ++Q +++ CS       E ND   +     E+V G+    + K  K  
Sbjct: 1258 EHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 802  KEVTALTSQ----TEMLR----------AQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
            K+V +L+SQ     E+L+           ++  LE +  S + ++D  ++ K+ LE  + 
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 848  TVSRKTHDASGQL--VLISQELLR--KERSLNELRVLLLEANRHSPGPERDLSREVHKAE 903
            T++ +  D+  +L     + E L   K+R   E+  L  +    +   ++     + K +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-----LEKTK 1429

Query: 904  WRIKEQKLKD---DIRGLREKLTGLDKEKSLSDQ---------RRYSLIDPSSAPELLRL 951
             R+ +Q+L D   D+   R+ ++ L+K++   DQ          +Y+     +  E    
Sbjct: 1430 NRL-QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 952  QHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQK 1006
            + + +S   AL +AL+  +++E+  + +++  +   +  +    N +H+ +K+++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKR 1542



 Score =  105 bits (261), Expect = 3e-22
 Identities = 158/695 (22%), Positives = 301/695 (43%), Gaps = 79/695 (11%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            ++  L+E++   +QL AER     ++      +   E+E A  K Q E+  AEA+ K   
Sbjct: 934  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLE 991

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE 476
              +LV   +  K+    +L EER  + DL   + EE     +L       +S + +LE  
Sbjct: 992  DEILVMDDQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049

Query: 477  LTLR---RGEIEELQQCLLHSGPPPPDHPDAAEI-LRLRERLLSASKEHQRESGVLRDKY 532
            L      R E+E+L++ L   G     H   A++  ++ E  +  +K+         ++ 
Sbjct: 1050 LKKEEKSRQELEKLKRKL--EGDASDFHEQIADLQAQIAELKMQLAKK--------EEEL 1099

Query: 533  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 592
            + AL     E+ +   A +K  +    + D  +   SE        ++K +    D  + 
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-----RNKAEKQKRDLGEE 1154

Query: 593  LEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALRE 652
            LE LK  L        ++  +  A  + ++ + + E+  L+   D ET  H  + + +R+
Sbjct: 1155 LEALKTEL--------EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 653  KLQEAQEELA-GLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQA 711
            K  +A EEL   L++  RA+  +  ++  LE + A       ELRV    K +VE++ + 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK 1263

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALC 766
                 L+ Q+   + K  D ER  RAE   K      EVES+   L  AE +   +    
Sbjct: 1264 -----LEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 767  SSQHTHMIESNDISEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLR 815
            +S  + + ++ ++ +E  R K           E    LQD+L++  +    L      L 
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLN 875
             Q+S  + K +     V+AL + K+R + E+E ++++  + +     + +   R ++ L+
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 876  ELRVLL---------LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIR 916
            +L V L         LE  +         E+++S      R+  +AE R KE K     R
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 917  GLREKLTGLDKEKSLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEK 974
             L E L   ++ +  +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 975  LMEAMRSCPD-KAQTIGNSGSANGIHQQDKAQKQE 1008
            L + +++  D K +   N  +  G  ++D   + E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 147/694 (21%), Positives = 286/694 (41%), Gaps = 62/694 (8%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 395  EIALLKAQHEQYVAEAEEKL---QRARL----LVESVRKEKVDLSNQLEEERRKVEDLQF 447
            E+   K + E  V E + K    +RAR      V  ++ E   ++  L E   K   L  
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 448  RVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEI 507
             V   S    D +     E  + L +  +L     E   LQ  L        +       
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375

Query: 508  LRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA---QEVAGLKDKV 564
            L ++   LS SK+  ++     +  E+  K +Q E++ L    E+ A    ++   K+++
Sbjct: 1376 LNIQ---LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 565  QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN-SGPGAQQKEIGELKA---VMEG 620
            QQ   + +  +DN +  + +L    +K  + L    N S   A +++  E +A     + 
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 621  IKMEHQLELGNLQAKHDLETA--MHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 678
            + +   LE   L+AK +LE    M   E E L     +  + +  L++  RA LE Q  +
Sbjct: 1493 LSLARALEEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEE 1550

Query: 679  HRLELQEAQDQRR---DAELRVH-ELEKLDVEYRGQAQAIEF--------LKEQISLAEK 726
             + +L+E +D+ +   DA+LR+   ++ L  ++    QA +         L+ Q+   E 
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 727  KMLDYERLQRA-EAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETI 784
            ++ D ER QRA  A  K+++E  L++  L A++ ++  E           +  D   E  
Sbjct: 1611 ELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 785  RTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD----------- 833
              + + + +     + +K+  +L +    L+  ++A E   K  + + +           
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 834  ---ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR----KERSLNELRVLLLEANR 886
               AL  EKRRLEA +  +  +  +  G +  +S  + +     E+  NEL      A +
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 887  HSPGPE------RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
            +    +      ++L  ++H+ E  +K  K K  I  L  K+  L+ E+   + R     
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLE-EQVEQEAREKQAA 1847

Query: 941  DPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
              S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 141/592 (23%), Positives = 255/592 (43%), Gaps = 91/592 (15%)

Query: 324  SSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 383
            S+V +   G+      +   + +Y  K +    L++     QQ ++ L+ + D +R  V+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 384  ------KATSHICEVEKEIALLKA-QHEQYVAEAEEK----LQRARLLVESVR-KEKVDL 431
                  +    +   EK I+   A + ++  AEA EK    L  AR L E++  KE+++ 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 432  SNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCL 491
            +N++   + ++EDL     ++ + K   EL    EKS+   LE ++   + ++EEL+   
Sbjct: 1512 TNKML--KAEMEDLVS--SKDDVGKNVHEL----EKSK-RALETQMEEMKTQLEELE--- 1559

Query: 492  LHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRESGVLRDKYEKALKAY 539
                    D   A E  +LR            ER L A  E   E    R + ++ L  Y
Sbjct: 1560 --------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK---RRQLQRQLHEY 1608

Query: 540  QAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSL 593
            + E++   K RA      +++ G LKD   QA S   G  +  K   KL +   D Q+ L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK-----EKE 648
            ED +A+        + EI       E  K    LE   +Q + DL  A   +     EKE
Sbjct: 1669 EDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718

Query: 649  ALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
             L E+L  +      LQ   R      AQLE +  + +  ++   D+ R A  +  +L  
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEVESLREKLLVAENRLQ 760
                 R  AQ  E  ++Q+    K++    +E     +++ K  + +L  K+   E +++
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 761  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKEVTALTSQTEMLRAQV 818
              EA      T  ++  D      + KE +  ++D  K+ ++ KE      Q E   A+V
Sbjct: 1839 Q-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE------QAEKGNARV 1886

Query: 819  SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
              L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V   +  LR+
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNALKSKLRR 1937



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 110/510 (21%), Positives = 216/510 (42%), Gaps = 62/510 (12%)

Query: 361  LKEKQQHIEQLLAE-----------RDLERAE----------VAKATSHICEVEKEIA-- 397
            L++KQ+  +QLLAE           RD   AE          +A+A     E ++E+   
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 398  --LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT 455
              +LKA+ E  V+  ++  +     V  + K K  L  Q+EE + ++E+L+  ++     
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 456  KGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLL 515
            K  LE+   A K    Q E +L  R  + EE ++ L         H    E+   R++  
Sbjct: 1569 KLRLEVNMQALKG---QFERDLQARDEQNEEKRRQLQRQL-----HEYETELEDERKQRA 1620

Query: 516  SASKEHQRESGVLRD---KYEKALKAYQAEVDKLRAAN------EKYAQEVAGLKDKVQQ 566
             A+   ++  G L+D   + + A+K  +  + +LR         ++  ++    +D++  
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680

Query: 567  ATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGA--QQKEIGELKAVMEGIKME 624
               EN       + K  SL +D  +  EDL A   +   A  +++E+ E  A     +  
Sbjct: 1681 TAKEN-------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 625  HQLELGNLQAK-HDLETAMHVKE--KEALREKLQEAQEELAGLQRHWRAQLEVQASQHRL 681
             Q E   L+A+   LE  +  ++   EA+ +++++A ++   L      +    A ++  
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST-AQKNES 1792

Query: 682  ELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ 740
              Q+ + Q ++   ++HE+E  +  +++    A+E    Q  L E+   +    Q A   
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEAREKQAATKS 1850

Query: 741  GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKR 800
             KQ+ + L+E LL  E+  +  E               +  +    +E  + +     K 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Query: 801  DKEVTALTSQTEMLRAQVSALESKCKSGEK 830
             +E+   T   E +  +V+AL+SK + G +
Sbjct: 1911 QRELDEATESNEAMGREVNALKSKLRRGNE 1940


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  115 bits (288), Expect = 2e-25
 Identities = 161/715 (22%), Positives = 315/715 (44%), Gaps = 117/715 (16%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 879  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLELTTVAEKSRV 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+L  V  ++++
Sbjct: 939  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 471  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERL------LSASKEHQRE 524
             +LE+E+ +   +  +L +                E   L ER+      L+  +E  + 
Sbjct: 988  KKLEDEILVMDDQNNKLSK----------------ERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDS 584
               L++K+E  +   +  + K     EK  QE+  LK K++   S+    + + ++++  
Sbjct: 1032 LTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 585  LASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV 644
            L     K  E+L+A L         EI +    ++ I+ E +  + +LQ   D E A   
Sbjct: 1088 LKMQLAKKEEELQAAL----ARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSERAARN 1142

Query: 645  KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-----QRRDAELRVHE 699
            K ++  R    +  EEL  L+      L+  A+Q  L  +  Q+     +  D E R HE
Sbjct: 1143 KAEKQKR----DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 700  LEKLDVEYRGQAQAIEFLKEQI--------------SLAEKKMLDYERLQRAEAQGKQEV 745
             +  ++  +  AQA+E L EQ+                 EK+  D     R   Q KQEV
Sbjct: 1199 AQVQEMRQK-HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL----QDKLNKRD 801
            E  ++KL   E ++Q +++ CS       E ND   +     E+V G+    + K  K  
Sbjct: 1258 EHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 802  KEVTALTSQ----TEMLR----------AQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
            K+V +L+SQ     E+L+           ++  LE +  S + ++D  ++ K+ LE  + 
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 848  TVSRKTHDASGQL--VLISQELLR--KERSLNELRVLLLEANRHSPGPERDLSREVHKAE 903
            T++ +  D+  +L     + E L   K+R   E+  L  +    +   ++     + K +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-----LEKTK 1429

Query: 904  WRIKEQKLKD---DIRGLREKLTGLDKEKSLSDQ---------RRYSLIDPSSAPELLRL 951
             R+ +Q+L D   D+   R+ ++ L+K++   DQ          +Y+     +  E    
Sbjct: 1430 NRL-QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 952  QHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQK 1006
            + + +S   AL +AL+  +++E+  + +++  +   +  +    N +H+ +K+++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKR 1542



 Score =  105 bits (261), Expect = 3e-22
 Identities = 158/695 (22%), Positives = 301/695 (43%), Gaps = 79/695 (11%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            ++  L+E++   +QL AER     ++      +   E+E A  K Q E+  AEA+ K   
Sbjct: 934  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLE 991

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE 476
              +LV   +  K+    +L EER  + DL   + EE     +L       +S + +LE  
Sbjct: 992  DEILVMDDQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049

Query: 477  LTLR---RGEIEELQQCLLHSGPPPPDHPDAAEI-LRLRERLLSASKEHQRESGVLRDKY 532
            L      R E+E+L++ L   G     H   A++  ++ E  +  +K+         ++ 
Sbjct: 1050 LKKEEKSRQELEKLKRKL--EGDASDFHEQIADLQAQIAELKMQLAKK--------EEEL 1099

Query: 533  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 592
            + AL     E+ +   A +K  +    + D  +   SE        ++K +    D  + 
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-----RNKAEKQKRDLGEE 1154

Query: 593  LEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALRE 652
            LE LK  L        ++  +  A  + ++ + + E+  L+   D ET  H  + + +R+
Sbjct: 1155 LEALKTEL--------EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 653  KLQEAQEELA-GLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQA 711
            K  +A EEL   L++  RA+  +  ++  LE + A       ELRV    K +VE++ + 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK 1263

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALC 766
                 L+ Q+   + K  D ER  RAE   K      EVES+   L  AE +   +    
Sbjct: 1264 -----LEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 767  SSQHTHMIESNDISEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLR 815
            +S  + + ++ ++ +E  R K           E    LQD+L++  +    L      L 
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLN 875
             Q+S  + K +     V+AL + K+R + E+E ++++  + +     + +   R ++ L+
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 876  ELRVLL---------LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIR 916
            +L V L         LE  +         E+++S      R+  +AE R KE K     R
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 917  GLREKLTGLDKEKSLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEK 974
             L E L   ++ +  +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 975  LMEAMRSCPD-KAQTIGNSGSANGIHQQDKAQKQE 1008
            L + +++  D K +   N  +  G  ++D   + E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 147/694 (21%), Positives = 286/694 (41%), Gaps = 62/694 (8%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 395  EIALLKAQHEQYVAEAEEKL---QRARL----LVESVRKEKVDLSNQLEEERRKVEDLQF 447
            E+   K + E  V E + K    +RAR      V  ++ E   ++  L E   K   L  
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 448  RVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEI 507
             V   S    D +     E  + L +  +L     E   LQ  L        +       
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375

Query: 508  LRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA---QEVAGLKDKV 564
            L ++   LS SK+  ++     +  E+  K +Q E++ L    E+ A    ++   K+++
Sbjct: 1376 LNIQ---LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 565  QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN-SGPGAQQKEIGELKA---VMEG 620
            QQ   + +  +DN +  + +L    +K  + L    N S   A +++  E +A     + 
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 621  IKMEHQLELGNLQAKHDLETA--MHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 678
            + +   LE   L+AK +LE    M   E E L     +  + +  L++  RA LE Q  +
Sbjct: 1493 LSLARALEEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEE 1550

Query: 679  HRLELQEAQDQRR---DAELRVH-ELEKLDVEYRGQAQAIEF--------LKEQISLAEK 726
             + +L+E +D+ +   DA+LR+   ++ L  ++    QA +         L+ Q+   E 
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 727  KMLDYERLQRA-EAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETI 784
            ++ D ER QRA  A  K+++E  L++  L A++ ++  E           +  D   E  
Sbjct: 1611 ELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 785  RTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD----------- 833
              + + + +     + +K+  +L +    L+  ++A E   K  + + +           
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 834  ---ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR----KERSLNELRVLLLEANR 886
               AL  EKRRLEA +  +  +  +  G +  +S  + +     E+  NEL      A +
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 887  HSPGPE------RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
            +    +      ++L  ++H+ E  +K  K K  I  L  K+  L+ E+   + R     
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLE-EQVEQEAREKQAA 1847

Query: 941  DPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
              S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 141/591 (23%), Positives = 254/591 (42%), Gaps = 91/591 (15%)

Query: 324  SSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 383
            S+V +   G+      +   + +Y  K +    L++     QQ ++ L+ + D +R  V+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 384  ------KATSHICEVEKEIALLKA-QHEQYVAEAEEK----LQRARLLVESVR-KEKVDL 431
                  +    +   EK I+   A + ++  AEA EK    L  AR L E++  KE+++ 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 432  SNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCL 491
            +N++   + ++EDL     ++ + K   EL    EKS+   LE ++   + ++EEL+   
Sbjct: 1512 TNKML--KAEMEDLVS--SKDDVGKNVHEL----EKSK-RALETQMEEMKTQLEELE--- 1559

Query: 492  LHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRESGVLRDKYEKALKAY 539
                    D   A E  +LR            ER L A  E   E    R + ++ L  Y
Sbjct: 1560 --------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK---RRQLQRQLHEY 1608

Query: 540  QAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSL 593
            + E++   K RA      +++ G LKD   QA S   G  +  K   KL +   D Q+ L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK-----EKE 648
            ED +A+        + EI       E  K    LE   +Q + DL  A   +     EKE
Sbjct: 1669 EDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718

Query: 649  ALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
             L E+L  +      LQ   R      AQLE +  + +  ++   D+ R A  +  +L  
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEVESLREKLLVAENRLQ 760
                 R  AQ  E  ++Q+    K++    +E     +++ K  + +L  K+   E +++
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 761  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKEVTALTSQTEMLRAQV 818
              EA      T  ++  D      + KE +  ++D  K+ ++ KE      Q E   A+V
Sbjct: 1839 Q-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE------QAEKGNARV 1886

Query: 819  SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 869
              L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V   +  LR
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  115 bits (288), Expect = 2e-25
 Identities = 161/715 (22%), Positives = 315/715 (44%), Gaps = 117/715 (16%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 872  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLELTTVAEKSRV 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+L  V  ++++
Sbjct: 932  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 471  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERL------LSASKEHQRE 524
             +LE+E+ +   +  +L +                E   L ER+      L+  +E  + 
Sbjct: 981  KKLEDEILVMDDQNNKLSK----------------ERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDS 584
               L++K+E  +   +  + K     EK  QE+  LK K++   S+    + + ++++  
Sbjct: 1025 LTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 585  LASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV 644
            L     K  E+L+A L         EI +    ++ I+ E +  + +LQ   D E A   
Sbjct: 1081 LKMQLAKKEEELQAAL----ARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSERAARN 1135

Query: 645  KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-----QRRDAELRVHE 699
            K ++  R    +  EEL  L+      L+  A+Q  L  +  Q+     +  D E R HE
Sbjct: 1136 KAEKQKR----DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 700  LEKLDVEYRGQAQAIEFLKEQI--------------SLAEKKMLDYERLQRAEAQGKQEV 745
             +  ++  +  AQA+E L EQ+                 EK+  D     R   Q KQEV
Sbjct: 1192 AQVQEMRQK-HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL----QDKLNKRD 801
            E  ++KL   E ++Q +++ CS       E ND   +     E+V G+    + K  K  
Sbjct: 1251 EHKKKKL---EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 802  KEVTALTSQ----TEMLR----------AQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
            K+V +L+SQ     E+L+           ++  LE +  S + ++D  ++ K+ LE  + 
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367

Query: 848  TVSRKTHDASGQL--VLISQELLR--KERSLNELRVLLLEANRHSPGPERDLSREVHKAE 903
            T++ +  D+  +L     + E L   K+R   E+  L  +    +   ++     + K +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-----LEKTK 1422

Query: 904  WRIKEQKLKD---DIRGLREKLTGLDKEKSLSDQ---------RRYSLIDPSSAPELLRL 951
             R+ +Q+L D   D+   R+ ++ L+K++   DQ          +Y+     +  E    
Sbjct: 1423 NRL-QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 952  QHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQK 1006
            + + +S   AL +AL+  +++E+  + +++  +   +  +    N +H+ +K+++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN-VHELEKSKR 1535



 Score =  105 bits (261), Expect = 3e-22
 Identities = 158/695 (22%), Positives = 301/695 (43%), Gaps = 79/695 (11%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            ++  L+E++   +QL AER     ++      +   E+E A  K Q E+  AEA+ K   
Sbjct: 927  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLE 984

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE 476
              +LV   +  K+    +L EER  + DL   + EE     +L       +S + +LE  
Sbjct: 985  DEILVMDDQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042

Query: 477  LTLR---RGEIEELQQCLLHSGPPPPDHPDAAEI-LRLRERLLSASKEHQRESGVLRDKY 532
            L      R E+E+L++ L   G     H   A++  ++ E  +  +K+         ++ 
Sbjct: 1043 LKKEEKSRQELEKLKRKL--EGDASDFHEQIADLQAQIAELKMQLAKK--------EEEL 1092

Query: 533  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 592
            + AL     E+ +   A +K  +    + D  +   SE        ++K +    D  + 
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-----RNKAEKQKRDLGEE 1147

Query: 593  LEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALRE 652
            LE LK  L        ++  +  A  + ++ + + E+  L+   D ET  H  + + +R+
Sbjct: 1148 LEALKTEL--------EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 653  KLQEAQEELA-GLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQA 711
            K  +A EEL   L++  RA+  +  ++  LE + A       ELRV    K +VE++ + 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK 1256

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALC 766
                 L+ Q+   + K  D ER  RAE   K      EVES+   L  AE +   +    
Sbjct: 1257 -----LEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 767  SSQHTHMIESNDISEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLR 815
            +S  + + ++ ++ +E  R K           E    LQD+L++  +    L      L 
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLN 875
             Q+S  + K +     V+AL + K+R + E+E ++++  + +     + +   R ++ L+
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 876  ELRVLL---------LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIR 916
            +L V L         LE  +         E+++S      R+  +AE R KE K     R
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 917  GLREKLTGLDKEKSLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEK 974
             L E L   ++ +  +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 975  LMEAMRSCPD-KAQTIGNSGSANGIHQQDKAQKQE 1008
            L + +++  D K +   N  +  G  ++D   + E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 147/694 (21%), Positives = 286/694 (41%), Gaps = 62/694 (8%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 395  EIALLKAQHEQYVAEAEEKL---QRARL----LVESVRKEKVDLSNQLEEERRKVEDLQF 447
            E+   K + E  V E + K    +RAR      V  ++ E   ++  L E   K   L  
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308

Query: 448  RVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEI 507
             V   S    D +     E  + L +  +L     E   LQ  L        +       
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368

Query: 508  LRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA---QEVAGLKDKV 564
            L ++   LS SK+  ++     +  E+  K +Q E++ L    E+ A    ++   K+++
Sbjct: 1369 LNIQ---LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 565  QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN-SGPGAQQKEIGELKA---VMEG 620
            QQ   + +  +DN +  + +L    +K  + L    N S   A +++  E +A     + 
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 621  IKMEHQLELGNLQAKHDLETA--MHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 678
            + +   LE   L+AK +LE    M   E E L     +  + +  L++  RA LE Q  +
Sbjct: 1486 LSLARALEEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEE 1543

Query: 679  HRLELQEAQDQRR---DAELRVH-ELEKLDVEYRGQAQAIEF--------LKEQISLAEK 726
             + +L+E +D+ +   DA+LR+   ++ L  ++    QA +         L+ Q+   E 
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 727  KMLDYERLQRA-EAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETI 784
            ++ D ER QRA  A  K+++E  L++  L A++ ++  E           +  D   E  
Sbjct: 1604 ELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 785  RTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD----------- 833
              + + + +     + +K+  +L +    L+  ++A E   K  + + +           
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 834  ---ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR----KERSLNELRVLLLEANR 886
               AL  EKRRLEA +  +  +  +  G +  +S  + +     E+  NEL      A +
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 887  HSPGPE------RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
            +    +      ++L  ++H+ E  +K  K K  I  L  K+  L+ E+   + R     
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLE-EQVEQEAREKQAA 1840

Query: 941  DPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
              S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 141/591 (23%), Positives = 254/591 (42%), Gaps = 91/591 (15%)

Query: 324  SSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 383
            S+V +   G+      +   + +Y  K +    L++     QQ ++ L+ + D +R  V+
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 384  ------KATSHICEVEKEIALLKA-QHEQYVAEAEEK----LQRARLLVESVR-KEKVDL 431
                  +    +   EK I+   A + ++  AEA EK    L  AR L E++  KE+++ 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 432  SNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCL 491
            +N++   + ++EDL     ++ + K   EL    EKS+   LE ++   + ++EEL+   
Sbjct: 1505 TNKML--KAEMEDLVS--SKDDVGKNVHEL----EKSK-RALETQMEEMKTQLEELE--- 1552

Query: 492  LHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRESGVLRDKYEKALKAY 539
                    D   A E  +LR            ER L A  E   E    R + ++ L  Y
Sbjct: 1553 --------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK---RRQLQRQLHEY 1601

Query: 540  QAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSL 593
            + E++   K RA      +++ G LKD   QA S   G  +  K   KL +   D Q+ L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK-----EKE 648
            ED +A+        + EI       E  K    LE   +Q + DL  A   +     EKE
Sbjct: 1662 EDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711

Query: 649  ALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
             L E+L  +      LQ   R      AQLE +  + +  ++   D+ R A  +  +L  
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEVESLREKLLVAENRLQ 760
                 R  AQ  E  ++Q+    K++    +E     +++ K  + +L  K+   E +++
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 761  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKEVTALTSQTEMLRAQV 818
              EA      T  ++  D      + KE +  ++D  K+ ++ KE      Q E   A+V
Sbjct: 1832 Q-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE------QAEKGNARV 1879

Query: 819  SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 869
              L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V   +  LR
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNALKSKLR 1929


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  115 bits (288), Expect = 2e-25
 Identities = 145/680 (21%), Positives = 288/680 (42%), Gaps = 80/680 (11%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    L +A++ K    + ++E 
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI-KLEQQVDDLEG 1042

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+  +  +  EK  L  +L+++  ++ +LQ ++E+
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED 1102

Query: 452  ESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSGPP 497
            E      L+      ++R+ +LEEE+   R               E+EE+ + L  +G  
Sbjct: 1103 EQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1162

Query: 498  PP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEK 552
                   +    AE  ++R  L  A+ +H+  +  LR K+  ++     ++D L+   +K
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1222

Query: 553  YAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIG 612
              +E + +K ++    S N+  +   K  L+ +     ++LED  + L S    QQ+ I 
Sbjct: 1223 LEKEKSEMKMEIDDLAS-NVETVSKAKGNLEKMC----RTLEDQLSELKSKEEEQQRLIN 1277

Query: 613  ELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQL 672
            +L A           + G LQ +   E +  + EKEAL  +L   ++         + QL
Sbjct: 1278 DLTA-----------QRGRLQTESG-EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325

Query: 673  EVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYE 732
            E +           Q  R D +L       L  +Y  + ++   L+  +S A  ++  + 
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDL-------LREQYEEEQESKAELQRALSKANTEVAQWR 1378

Query: 733  RLQRAEA-QGKQEVESLREKLL----VAENRLQAVEALCSSQHTHMIESNDISEETIRTK 787
                 +A Q  +E+E  ++KL      AE  ++AV A C+S          + +   R +
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS----------LEKTKQRLQ 1428

Query: 788  ETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
              VE L   + + +    AL  +       ++  + KC+    +++A  KE R L  EL 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 848  TVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPER----------DLSR 897
             +     ++  QL  + +E    ++ +++L   + E  +     E+          +L  
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 898  EVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
             + +AE  ++ ++ K  I  ++ +L  +  E       +   ID       +R+   + S
Sbjct: 1549 ALEEAEASLEHEEGK--ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH-IRIVESMQS 1605

Query: 958  TEDALRDALDQAQQVEKLME 977
            T DA   + + A +++K ME
Sbjct: 1606 TLDAEIRSRNDAIRLKKKME 1625



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 127/630 (20%), Positives = 261/630 (41%), Gaps = 117/630 (18%)

Query: 349  RKISGTTALQEAL-KEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHE 404
            +KI    A  EA  KE ++ +  LL E++  + +V      + + E+   ++   K Q E
Sbjct: 863  QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922

Query: 405  QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTV 464
              + E  E+ +    +   +  +K  L ++  E ++ ++DL+       +T   +E    
Sbjct: 923  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE-------LTLAKVEKEKH 975

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
            A +++V  L EE+                                L E +   +KE +  
Sbjct: 976  ATENKVKNLTEEMA------------------------------GLDETIAKLTKEKK-- 1003

Query: 525  SGVLRDKYEKALKAYQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK 581
               L++ +++ L   QAE DK   L  A  K  Q+V  L+  ++Q     M L +  K K
Sbjct: 1004 --ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDL-ERAKRK 1060

Query: 582  LDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA 641
            L+      Q+S+ D++               E + + E +K + + E+ NLQ+K + E A
Sbjct: 1061 LEGDLKLAQESIMDIE--------------NEKQQLDEKLK-KKEFEISNLQSKIEDEQA 1105

Query: 642  MHVKEKEALRE---KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD---------- 688
            + ++ ++ ++E   +++E +EE+   +R  RA+ E Q S    EL+E  +          
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEA-ERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164

Query: 689  ------QRRDAELRV--HELEKLDVEY--------RGQAQAIEFLKEQISLAEKKMLDYE 732
                  ++R+AE +    +LE+  +++        +  A ++  L EQI   ++     +
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK---Q 1221

Query: 733  RLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEG 792
            +L++ +++ K E++ L   +         +E +C +    + E     EE  R    +  
Sbjct: 1222 KLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA 1281

Query: 793  LQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKE-KRRLEAELETVSR 851
             + +L     E +    + E L +Q+S        G++     ++E KR+LE E++  + 
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-------RGKQAFTQQIEELKRQLEEEIKAKNA 1334

Query: 852  KTH---DASGQLVLISQELLRKERSLNELRVLLLEANR---------HSPGPERDLSREV 899
              H    +     L+ ++   ++ S  EL+  L +AN           +   +R    E 
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE 1394

Query: 900  HKAEWRIKEQKLKDDIRGLREKLTGLDKEK 929
             K +   + Q  ++ +  +  K   L+K K
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 143/629 (22%), Positives = 258/629 (41%), Gaps = 115/629 (18%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I    AL  AL+         ++Q+ E+  ++ +L+RA ++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA-LS 1368

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA + + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 440  RKVEDLQFRVEEESITKGDLELTT------VAE-KSRVLQLEEELTLRRGEIEELQQCLL 492
             +VEDL   VE  +     L+         +AE K +  +   EL   + E   L   L 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 493  HSGPPPPDHPDAAEILRLRERLL----SASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 548
                   +  D  E L+   + L    S   E   E G    + EK  K  + E  +L+A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 549  ANEKYAQEVAGLKDKV-------QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN 601
            A E+    +   + K+        Q  SE    +     ++D L  +H + +E +++TL+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 602  SGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL-----------ETAMHVKEKE 648
            +   ++   I  LK  MEG   +ME QL   N  A   L           +T +H+ +  
Sbjct: 1609 AEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD-- 1665

Query: 649  ALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE-----AQDQRRDAELRVHEL-- 700
            ALR + ++ +E+LA ++R     Q E++  +  LE  E     A+ +  DA  RV  L  
Sbjct: 1666 ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724

Query: 701  ---------EKLDVEYRGQAQAIEFLKEQISLAEKK---------MLDYE---------R 733
                     +KL+ +       +E + ++   AE+K         M+  E          
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784

Query: 734  LQRAEAQGKQEVESLREKLLVAEN--------RLQAVEALCSSQHTHMIESNDISEETIR 785
            L+R +   +Q V+ L+ +L  AE         ++Q +EA             ++  E  R
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE------GEVESEQKR 1838

Query: 786  TKETVEGLQDKLNKRDKEVTALTSQTE--------------MLRAQVSALESKCKSGEKK 831
              E V+GL+    K ++ V  LT QTE               L+A+V + + + +  E++
Sbjct: 1839 NAEAVKGLR----KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894

Query: 832  VDALLKEKRRLEAELETVSRKTHDASGQL 860
             +  L + R+L+ ELE    +   A  Q+
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQV 1923



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 107/488 (21%), Positives = 206/488 (42%), Gaps = 58/488 (11%)

Query: 515  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 574
            L  S E ++E   ++++++K          K +   EK    +    D   Q  +E  GL
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
             D  + + D L     K+   L+A +       + E  E+ A +   K + + E   L+ 
Sbjct: 905  ADA-EERCDQLI----KTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELKK 958

Query: 635  KHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR 691
              D   L  A   KEK A   K++   EE+AGL      +   + ++ +  LQEA  Q  
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKLTKEKKALQEAHQQTL 1013

Query: 692  D----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAEAQGKQEVE 746
            D     E +V+ L K  ++   Q   +E   EQ    EKK+ +D   L+RA+ + + +++
Sbjct: 1014 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ----EKKLRMD---LERAKRKLEGDLK 1066

Query: 747  SLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TVEGLQDKLNKRDKEVT 805
              +E ++  EN  Q +                  +E ++ KE  +  LQ K+        
Sbjct: 1067 LAQESIMDIENEKQQL------------------DEKLKKKEFEISNLQSKIEDEQALGI 1108

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             L  + + L+A++  LE + ++         K++  L  ELE +S +  +A G      +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
               ++E    ++R  L EA          L ++   +   + EQ   D+++ +++K   L
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ--IDNLQRVKQK---L 1223

Query: 926  DKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQVEKLMEAMR 980
            +KEKS   + +  + D +S  E +      L+    + ED L +   + ++ ++L+  + 
Sbjct: 1224 EKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 981  SCPDKAQT 988
            +   + QT
Sbjct: 1281 AQRGRLQT 1288


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  115 bits (288), Expect = 2e-25
 Identities = 145/680 (21%), Positives = 288/680 (42%), Gaps = 80/680 (11%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    L +A++ K    + ++E 
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI-KLEQQVDDLEG 1042

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+  +  +  EK  L  +L+++  ++ +LQ ++E+
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED 1102

Query: 452  ESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSGPP 497
            E      L+      ++R+ +LEEE+   R               E+EE+ + L  +G  
Sbjct: 1103 EQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1162

Query: 498  PP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEK 552
                   +    AE  ++R  L  A+ +H+  +  LR K+  ++     ++D L+   +K
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1222

Query: 553  YAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIG 612
              +E + +K ++    S N+  +   K  L+ +     ++LED  + L S    QQ+ I 
Sbjct: 1223 LEKEKSEMKMEIDDLAS-NVETVSKAKGNLEKMC----RTLEDQLSELKSKEEEQQRLIN 1277

Query: 613  ELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQL 672
            +L A           + G LQ +   E +  + EKEAL  +L   ++         + QL
Sbjct: 1278 DLTA-----------QRGRLQTESG-EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325

Query: 673  EVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYE 732
            E +           Q  R D +L       L  +Y  + ++   L+  +S A  ++  + 
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDL-------LREQYEEEQESKAELQRALSKANTEVAQWR 1378

Query: 733  RLQRAEA-QGKQEVESLREKLL----VAENRLQAVEALCSSQHTHMIESNDISEETIRTK 787
                 +A Q  +E+E  ++KL      AE  ++AV A C+S          + +   R +
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS----------LEKTKQRLQ 1428

Query: 788  ETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELE 847
              VE L   + + +    AL  +       ++  + KC+    +++A  KE R L  EL 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 848  TVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPER----------DLSR 897
             +     ++  QL  + +E    ++ +++L   + E  +     E+          +L  
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 898  EVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
             + +AE  ++ ++ K  I  ++ +L  +  E       +   ID       +R+   + S
Sbjct: 1549 ALEEAEASLEHEEGK--ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH-IRIVESMQS 1605

Query: 958  TEDALRDALDQAQQVEKLME 977
            T DA   + + A +++K ME
Sbjct: 1606 TLDAEIRSRNDAIRLKKKME 1625



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 127/630 (20%), Positives = 261/630 (41%), Gaps = 117/630 (18%)

Query: 349  RKISGTTALQEAL-KEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHE 404
            +KI    A  EA  KE ++ +  LL E++  + +V      + + E+   ++   K Q E
Sbjct: 863  QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922

Query: 405  QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTV 464
              + E  E+ +    +   +  +K  L ++  E ++ ++DL+       +T   +E    
Sbjct: 923  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE-------LTLAKVEKEKH 975

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
            A +++V  L EE+                                L E +   +KE +  
Sbjct: 976  ATENKVKNLTEEMA------------------------------GLDETIAKLTKEKK-- 1003

Query: 525  SGVLRDKYEKALKAYQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK 581
               L++ +++ L   QAE DK   L  A  K  Q+V  L+  ++Q     M L +  K K
Sbjct: 1004 --ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDL-ERAKRK 1060

Query: 582  LDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA 641
            L+      Q+S+ D++               E + + E +K + + E+ NLQ+K + E A
Sbjct: 1061 LEGDLKLAQESIMDIE--------------NEKQQLDEKLK-KKEFEISNLQSKIEDEQA 1105

Query: 642  MHVKEKEALRE---KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD---------- 688
            + ++ ++ ++E   +++E +EE+   +R  RA+ E Q S    EL+E  +          
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEA-ERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164

Query: 689  ------QRRDAELRV--HELEKLDVEY--------RGQAQAIEFLKEQISLAEKKMLDYE 732
                  ++R+AE +    +LE+  +++        +  A ++  L EQI   ++     +
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK---Q 1221

Query: 733  RLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEG 792
            +L++ +++ K E++ L   +         +E +C +    + E     EE  R    +  
Sbjct: 1222 KLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA 1281

Query: 793  LQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKE-KRRLEAELETVSR 851
             + +L     E +    + E L +Q+S        G++     ++E KR+LE E++  + 
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-------RGKQAFTQQIEELKRQLEEEIKAKNA 1334

Query: 852  KTH---DASGQLVLISQELLRKERSLNELRVLLLEANR---------HSPGPERDLSREV 899
              H    +     L+ ++   ++ S  EL+  L +AN           +   +R    E 
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE 1394

Query: 900  HKAEWRIKEQKLKDDIRGLREKLTGLDKEK 929
             K +   + Q  ++ +  +  K   L+K K
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 143/629 (22%), Positives = 258/629 (41%), Gaps = 115/629 (18%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I    AL  AL+         ++Q+ E+  ++ +L+RA ++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA-LS 1368

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA + + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 440  RKVEDLQFRVEEESITKGDLELTT------VAE-KSRVLQLEEELTLRRGEIEELQQCLL 492
             +VEDL   VE  +     L+         +AE K +  +   EL   + E   L   L 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 493  HSGPPPPDHPDAAEILRLRERLL----SASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 548
                   +  D  E L+   + L    S   E   E G    + EK  K  + E  +L+A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 549  ANEKYAQEVAGLKDKV-------QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN 601
            A E+    +   + K+        Q  SE    +     ++D L  +H + +E +++TL+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608

Query: 602  SGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL-----------ETAMHVKEKE 648
            +   ++   I  LK  MEG   +ME QL   N  A   L           +T +H+ +  
Sbjct: 1609 AEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD-- 1665

Query: 649  ALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE-----AQDQRRDAELRVHEL-- 700
            ALR + ++ +E+LA ++R     Q E++  +  LE  E     A+ +  DA  RV  L  
Sbjct: 1666 ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724

Query: 701  ---------EKLDVEYRGQAQAIEFLKEQISLAEKK---------MLDYE---------R 733
                     +KL+ +       +E + ++   AE+K         M+  E          
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784

Query: 734  LQRAEAQGKQEVESLREKLLVAEN--------RLQAVEALCSSQHTHMIESNDISEETIR 785
            L+R +   +Q V+ L+ +L  AE         ++Q +EA             ++  E  R
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE------GEVESEQKR 1838

Query: 786  TKETVEGLQDKLNKRDKEVTALTSQTE--------------MLRAQVSALESKCKSGEKK 831
              E V+GL+    K ++ V  LT QTE               L+A+V + + + +  E++
Sbjct: 1839 NAEAVKGLR----KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894

Query: 832  VDALLKEKRRLEAELETVSRKTHDASGQL 860
             +  L + R+L+ ELE    +   A  Q+
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQV 1923



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 107/488 (21%), Positives = 206/488 (42%), Gaps = 58/488 (11%)

Query: 515  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 574
            L  S E ++E   ++++++K          K +   EK    +    D   Q  +E  GL
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
             D  + + D L     K+   L+A +       + E  E+ A +   K + + E   L+ 
Sbjct: 905  ADA-EERCDQLI----KTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELKK 958

Query: 635  KHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR 691
              D   L  A   KEK A   K++   EE+AGL      +   + ++ +  LQEA  Q  
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKLTKEKKALQEAHQQTL 1013

Query: 692  D----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAEAQGKQEVE 746
            D     E +V+ L K  ++   Q   +E   EQ    EKK+ +D   L+RA+ + + +++
Sbjct: 1014 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ----EKKLRMD---LERAKRKLEGDLK 1066

Query: 747  SLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TVEGLQDKLNKRDKEVT 805
              +E ++  EN  Q +                  +E ++ KE  +  LQ K+        
Sbjct: 1067 LAQESIMDIENEKQQL------------------DEKLKKKEFEISNLQSKIEDEQALGI 1108

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             L  + + L+A++  LE + ++         K++  L  ELE +S +  +A G      +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
               ++E    ++R  L EA          L ++   +   + EQ   D+++ +++K   L
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ--IDNLQRVKQK---L 1223

Query: 926  DKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQVEKLMEAMR 980
            +KEKS   + +  + D +S  E +      L+    + ED L +   + ++ ++L+  + 
Sbjct: 1224 EKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 981  SCPDKAQT 988
            +   + QT
Sbjct: 1281 AQRGRLQT 1288


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  112 bits (279), Expect = 2e-24
 Identities = 171/715 (23%), Positives = 303/715 (42%), Gaps = 100/715 (13%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            +++  K KQQ I +L  E D  RAEV  A     E  +   LL +      A  +E+L+R
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME--TLLSSN-----ASMKEELER 1730

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE 476
             ++  E++ K+   L ++ +    +V+DL+ ++E     + +LE T   +    +  EE 
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT-EEG 1789

Query: 477  LTLRRGEIEELQQCLLHSGPPPPDHPDAA----------------------EILRLRERL 514
                 GE EE     + + P   +   +A                      +I +L+ER+
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERI 1849

Query: 515  LSASKEHQR----------ESGVLRDKY---EKALKAYQAEVDKLRAANEKYAQEVAGLK 561
                +E Q+          E   L  +    +  LK  Q EV K+   N++  +E++ + 
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909

Query: 562  DKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL------KATLNSGPGAQQKEIGELK 615
               + A  E   L +   ++L  L        +D+         L S     +K + EL+
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969

Query: 616  A-----VMEGIKMEHQLELGNLQ----AKHDLETAMHVKEKEALREKLQEAQEELAGLQR 666
                  V E  K+E ++    L+    A+ +     H KE   L+E L+E Q+E+  LQ+
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE---LQELLKEKQQEVKQLQK 2026

Query: 667  HW-RAQLEVQASQHRLELQE--AQDQRRDAELRVHELEKLDVEYRGQAQAI-----EFLK 718
               R Q ++ A +  ++  E    + ++D E+    L +  VE+R +AQA        L 
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA-VEHRKKAQAELASFKVLLD 2085

Query: 719  EQISLAEKKMLDYERLQRAEAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESN 777
            +  S A + + D  +L++     K+ V+S +++K    E RL+  E     +  +M E  
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145

Query: 778  D-ISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALL 836
            D +  E +  +ET+  +Q  LNK+DKEV  L    +    Q++A      S +   D ++
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI 2205

Query: 837  KEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLS 896
             E ++ E       RK  DA   +    +E+  KE + + L+  L + + H    + ++S
Sbjct: 2206 DEAKKWE-------RKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 897  REVH-KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQL 955
            R  H K  W  K Q      + + + L G +KE  LS       +  SS  EL +L+ +L
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE-LLSQLEETRHLYHSSQNELAKLESEL 2314

Query: 956  MSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1010
             S +D L D          L  ++  C ++       G+  GI +Q +A  Q  K
Sbjct: 2315 KSLKDQLTD----------LSNSLEKCKEQ------KGNLEGIIRQQEADIQNSK 2353



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 165/809 (20%), Positives = 331/809 (40%), Gaps = 114/809 (14%)

Query: 308  VSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQH 367
            +S  T    S S+ S  S   +V    S    +     +  +       L+E  ++ ++ 
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1862

Query: 368  IEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKE 427
             + L  E++   ++++     +  +++E+  +   ++Q     +E+L R   L E+  +E
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI----QEELSRVTKLKETAEEE 1918

Query: 428  KVDLS----NQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEE---LTLR 480
            K DL     NQL E    + +    V +  I    LE      K  V +LEEE   L   
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978

Query: 481  RGEIE-----ELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE-- 533
            + ++E     E  + +  +   P +   A E+  L +      K+ Q++    ++K    
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038

Query: 534  ----KALKAYQAEVDK-LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASD 588
                KAL+  Q E  K L    E  AQ V   K K Q   +    L+D+ +S+   + +D
Sbjct: 2039 ERTVKALEFVQTESQKDLEITKENLAQAVEHRK-KAQAELASFKVLLDDTQSEAARVLAD 2097

Query: 589  HQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHD----------- 637
            + K  ++L++   S     +++  +L+  +E  + +H  E  N+Q K D           
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157

Query: 638  ----LETAMHVKEKEA--LREKLQEAQEELAGLQRH-----------------WRAQLE- 673
                ++  ++ K+KE   L+E L     +LA   +                  W  +   
Sbjct: 2158 TIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD 2217

Query: 674  -VQASQHRLELQE-----AQDQRRDAELRVHELE---------------KLDVEYRGQAQ 712
             +Q+ +  + L+E      +DQ R   + + EL+               K   E + Q +
Sbjct: 2218 AIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277

Query: 713  AIEFL----KEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQA------- 761
              + L    KE +S  E+    Y   Q   A+ + E++SL+++L    N L+        
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337

Query: 762  VEALCSSQHTHMIESNDISEETIRT-----KETVEGLQDKLNKRDKEVTALTS-QTEMLR 815
            +E +   Q    I+++  S E + T     +E    L +++N +++++ +L S + E ++
Sbjct: 2338 LEGIIRQQEAD-IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ 2396

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLV----LISQELLRKE 871
              ++ L  +     K+++ LL ++      LE  ++K  D + QL+     I +E ++++
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456

Query: 872  RSLNEL--RVLLLEANR------HSPGPERDLSREVHK----AEWRIKEQKLKDDIRGLR 919
              L+     +  L+ +R      +    ER LS  + K     E   +  KLK++IRGLR
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR 2516

Query: 920  EKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAM 979
              +  L+ E +  D       +  +    ++   Q    E  L+   +   +  KL E +
Sbjct: 2517 SHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576

Query: 980  RSCPDKAQTIGNSGSANGIHQQDKAQKQE 1008
            +   +  + +  S +A    +QD +++ E
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIE 2605



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 157/710 (22%), Positives = 298/710 (41%), Gaps = 98/710 (13%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            +   S LL + + +  +       L++ L++K + I Q L    L++ E A  TS   +V
Sbjct: 399  KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS-FPDV 457

Query: 393  EKEIALLKAQHEQYVAEAEEKL-----QRARLLVESVRKEKVDLSNQLEEERRKVEDLQF 447
              E    +A  E+ +A  ++++     ++  LL+ S+  E++   N+    +  + + Q 
Sbjct: 458  YNEGT--QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQN 515

Query: 448  RVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEI 507
            R  E      ++ +  +A K            R    EE  Q +L +          ++ 
Sbjct: 516  RTGEADREVSEISIVDIANK------------RSSSAEESGQDVLEN--------TFSQK 555

Query: 508  LRLRERLLSASKEHQRESGVLRDKYE-KALKAYQAEVDKLRAANEKYAQEVAGLKDKV-Q 565
             +    LL   KE Q E   L+ + + K  +    EV   +   +   + +A +K KV  
Sbjct: 556  HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFL 615

Query: 566  QATSENMGLMDNWKSKLDSL-----ASDHQK------SLEDLKATLNSGPGAQQKEIGEL 614
            + T ++  LM N +S L ++     +++HQ       SL D    L S    +Q     L
Sbjct: 616  EDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKS---TKQDGDKSL 672

Query: 615  KAVMEGIKMEHQLELGNLQAKH-DLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLE 673
             AV + I   HQ EL  L+++  +LE   H K +E   + L E  +E++ L +    + +
Sbjct: 673  SAVPD-IGQCHQDELERLKSQILELELNFH-KAQEIYEKNLDEKAKEISNLNQLIE-EFK 729

Query: 674  VQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAE---KKMLD 730
              A  +        ++R     +V EL  +  E R Q + +E     ++LAE   ++ LD
Sbjct: 730  KNADNNSSAFTALSEERDQLLSQVKELSMV-TELRAQVKQLE-----MNLAEAERQRRLD 783

Query: 731  YERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETV 790
            YE     +    +++ SL    + A+++   +E L +       E +D+  +       +
Sbjct: 784  YESQTAHDNLLTEQIHSLS---IEAKSKDVKIEVLQN-------ELDDVQLQFSEQSTLI 833

Query: 791  EGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE---KKVDALLKEKRRLEAELE 847
              LQ +L  ++ EV     +   + ++V  L       E    K+D LL EK+R   ++E
Sbjct: 834  RSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR---DVE 890

Query: 848  TVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSRE----VHKAE 903
            T+ +   +   Q+  IS  +  K   LNE         + S G E    +E    + +AE
Sbjct: 891  TLQQTIEEKDQQVTEISFSMTEKMVQLNE--------EKFSLGVEIKTLKEQLNLLSRAE 942

Query: 904  WRIKEQKLKDD--IRGLREKLTGLDKEKSLSD---QRRYSLIDPSSAPELLRLQHQLMST 958
               KEQ  +D+    GL++    +     +S    Q  + L+   +     +LQ  L++ 
Sbjct: 943  EAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINR 1002

Query: 959  EDALRDALDQAQQVEKLMEAMRSCPDKA-QTIGNSGSANGIHQQDKAQKQ 1007
            ++ L       Q+V +L E + +  D++ + I  S +  G  ++DK  K+
Sbjct: 1003 KELL-------QRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE 1045



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 135/631 (21%), Positives = 264/631 (41%), Gaps = 110/631 (17%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
            AL+   ++K++ ++++ + +  + AE  +      E++KE  +L   +E    EAE    
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE---- 1630

Query: 416  RARLLVESVRKEKVDLSNQL---EEERRKVE-DLQFRVEEESITKGDLELTTVAEKSRVL 471
            R + +VE+VR+EK +L  +L   E  +++ E  LQ   +E    K  +     +++ ++L
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690

Query: 472  QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDK 531
            +LEEE    R E+                HP         E LLS++   + E   ++ +
Sbjct: 1691 ELEEENDRLRAEV----------------HPAGDTAKECMETLLSSNASMKEELERVKME 1734

Query: 532  YEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWK------------ 579
            YE   K +Q+    L +  +  ++EV  LK +++   S+   L    K            
Sbjct: 1735 YETLSKKFQS----LMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790

Query: 580  -------SKLDSLA-SDHQKSLEDLKATLNSGPGAQQ------------KEIGELKAVME 619
                    + DSL+ S      E + +  ++ P   +            ++I +LK  + 
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850

Query: 620  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------WRAQLE 673
            G++ E Q    N +    LE      EK  L  ++     EL  LQ           Q++
Sbjct: 1851 GLEEEKQ---KNKEFSQTLE-----NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ 1902

Query: 674  VQASQHRLELQEAQDQRRDAELR-VHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYE 732
             + S+     + A++++ D E R +++L +L+       Q +   + +  L E +M + +
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK 1962

Query: 733  RLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEG 792
            +      + KQ++   + K          VE+    ++   I+    +++    K   + 
Sbjct: 1963 KCVSELEEEKQQLVKEKTK----------VESEIRKEYLEKIQG---AQKEPGNKSHAKE 2009

Query: 793  LQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRK 852
            LQ+ L ++ +EV  L       + ++SALE   K+ E       + ++ LE   E +++ 
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE---FVQTESQKDLEITKENLAQA 2066

Query: 853  T-HDASGQLVLISQELLRKERSLNELRVLL--------LEANRHS-----PGPERDLSRE 898
              H    Q  L S ++L  +      RVL         L++N+ S        + DL R 
Sbjct: 2067 VEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126

Query: 899  VHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 929
            + +AE    E+ LK+  + ++EKL  L +EK
Sbjct: 2127 LEQAE----EKHLKEK-KNMQEKLDALRREK 2152



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 133/700 (19%), Positives = 282/700 (40%), Gaps = 110/700 (15%)

Query: 339  LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAER----DLERAEVAKATSHIC---- 390
            L+ + +     K +    LQ  + E Q  I++L+       D +   + K T  I     
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152

Query: 391  --------EVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKV 442
                    E+E++I  L+ + EQ   + +E L   + +++  ++++  L  +L++++   
Sbjct: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212

Query: 443  EDLQFRVEEESITKGDLELTTVAEKSRVLQLE--EELTLRRGEIEELQQCLLHSGPPPPD 500
              LQ + +E+S      E   + ++ R LQ++  E +  +    ++ + C    G     
Sbjct: 1213 NRLQEQFDEQS-----KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPG----- 1262

Query: 501  HPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL 560
                     L E L  A+++H  +  VL         ++  +   L+         VA +
Sbjct: 1263 ---------LEEPLFKATEQHHTQP-VLESNLCPDWPSHSEDASALQGGTS-----VAQI 1307

Query: 561  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 620
            K ++++  +E + L    + K+ S  S+  K  E++   L      Q  EI  LK V   
Sbjct: 1308 KAQLKEIEAEKVEL----ELKVSSTTSELTKKSEEV-FQLQEQINKQGLEIESLKTV--- 1359

Query: 621  IKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHR 680
                H+ E+                  E+L++KL+ +Q ++AGL+     Q ++   Q  
Sbjct: 1360 ---SHEAEV----------------HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKL 1400

Query: 681  LELQEAQDQRRDAELRVHE--LEKLDVEYRGQAQAIEFLKEQISLAEKKMLD-YERLQRA 737
            +  +E        +L   E  L K+  E   Q   I+ L  Q+ +  K+  +  ++LQ  
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE 1460

Query: 738  EAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKL 797
              + KQ+ E + E+    +   + ++A   S+   + E+  + EE    + T+E L   L
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL 1520

Query: 798  NKRDKEVTALTSQ-------------------TEMLRAQVS--ALESKCKSGEKKVDALL 836
               + +V+A   +                   TEM R+ +   +L S C+S +  ++ L 
Sbjct: 1521 ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLT 1580

Query: 837  KEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLS 896
            ++K +L  E+E++           +  S E   K + L +   +LL++  +       + 
Sbjct: 1581 EDKEKLVKEIESL-------KSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633

Query: 897  REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID------PSSAPELLR 950
              V     R ++Q+L   +R         +K+   ++Q    + +       S   ++L 
Sbjct: 1634 HVVEAV--RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691

Query: 951  LQHQLMSTEDALRDALDQAQQ-VEKLMEAMRSCPDKAQTI 989
            L+ +       +  A D A++ +E L+ +  S  ++ + +
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 134/683 (19%), Positives = 278/683 (40%), Gaps = 106/683 (15%)

Query: 368  IEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKE 427
            ++  L  ++ E  E A+   HI    +E++   +Q E  + + ++ L   +  VE++++ 
Sbjct: 836  LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895

Query: 428  KVDLSNQLEEERRKVEDLQFRVEEESITKG--------DLELTTVAEKSRVLQLEEELTL 479
              +   Q+ E    + +   ++ EE  + G         L L + AE+++  Q+EE+  +
Sbjct: 896  IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955

Query: 480  RRG--------------EIEELQQ--CLLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 523
              G                EELQ    LL            A ++  R+ LL      + 
Sbjct: 956  SSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN-RKELLQRVSRLEE 1014

Query: 524  ESGVLRDKYEKALKAYQAEVDKLRA--ANEKYAQEVAG---------LKDKVQQATSENM 572
            E   L+D+ +K +   + E  ++     N++Y+++            LK  + +   E  
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074

Query: 573  GLMDNWKSKL------DSLASDHQKSLED-------LKATLNSGPGAQQKEI-------- 611
             +  + + KL       +L     ++L+D       L+A ++      QK I        
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134

Query: 612  -GELKAVMEGIKMEHQLELGNLQAKHDLETAMHV--KEKEALREKLQEAQEELAGL---- 664
               +  V E + +       +   K +LE  +    KEKE L++KLQEA      +    
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194

Query: 665  ---QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQA-IEFLKEQ 720
               +RH R +L+ Q   +    ++  +Q ++ E    +L +L ++ R      +    +Q
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254

Query: 721  ISLAEKKMLDYERLQRAEAQGKQEV----------------ESLREKLLVAENRLQAVEA 764
             S +    L+    +  E    Q V                 +L+    VA+ + Q  E 
Sbjct: 1255 ESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI 1314

Query: 765  LCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESK 824
                    +  S+  SE T +++E  + LQ+++NK+  E+ +L + +        +L+ K
Sbjct: 1315 EAEKVELELKVSSTTSELTKKSEEVFQ-LQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373

Query: 825  CKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEA 884
             +S + ++ A L+  R L+ +L+ + +        +  +S +L  KE +L +++  ++E 
Sbjct: 1374 LESSQLQI-AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE- 1431

Query: 885  NRHSPGPERDLSREVH-KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPS 943
                   + DL + +H + E + KE           E++  L  E     Q+   + + S
Sbjct: 1432 -------QEDLIKALHTQLEMQAKEHD---------ERIKQLQVELCEMKQKPEEIGEES 1475

Query: 944  SAPELL--RLQHQLMSTEDALRD 964
             A + +  +LQ  L+S ++AL++
Sbjct: 1476 RAKQQIQRKLQAALISRKEALKE 1498



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 149/696 (21%), Positives = 274/696 (39%), Gaps = 112/696 (16%)

Query: 363  EKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL-----QRA 417
            EK Q I++  AE +  + E+    SH+ ++  E A L A+  QY  +  + +     Q+ 
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK 2552

Query: 418  RLLVESVRKEK------VDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVL 471
            +LL   +++ K        L  +L+E     EDL+         K DL     + K  + 
Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612

Query: 472  QLEEELTLRRGEIEELQQCLLHSGPPPPDH----------PDAAEILRLRERLLSASKEH 521
            QL  ++T  +   EE    L H+     +                I  L E L+   KE 
Sbjct: 2613 QLTRQVTALQ---EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669

Query: 522  QRESGVLRDKYEKALKAYQAEVDKLRAANE-------KYAQEVAGLKDKVQQATSENMGL 574
             ++ G + DK +K LK    +   +R   E       + A+++  ++ K+   T EN GL
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729

Query: 575  MDNWKSKLDSLAS-----DH-QKSLEDLKATLNSG--PGAQQKEIGELKAVMEGIKMEHQ 626
                +S   S++S     DH  + L++LK   ++     AQ KE G L    + +  E  
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789

Query: 627  LELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEA 686
              + + +          +   E L ++L    E+L     H  +QLE   +Q +   +  
Sbjct: 2790 FSMNSTEEN-------SLSHLEKLNQQLLSKDEQLL----HLSSQLEDSYNQVQSFSKAM 2838

Query: 687  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ---GKQ 743
               + + +   +ELEK             F K +           E  QR+ AQ      
Sbjct: 2839 ASLQNERDHLWNELEK-------------FRKSE-----------EGKQRSAAQPSTSPA 2874

Query: 744  EVESLREKLLVAEN-RLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNK-RD 801
            EV+SL++ +   +N R + ++ L + Q  ++  + +I+E        +  L+ +L + +D
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE--------LHPLKAQLQEYQD 2926

Query: 802  KEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLV 861
            K       Q E+ +  +S      +   +K    + E+R  E  L  +S K    S    
Sbjct: 2927 KTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH--- 2983

Query: 862  LISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHK---AEWRIKEQKLKDDIRGL 918
               Q L+R+ RS +     L    +    PE   S +  +    E  +   +L D ++ +
Sbjct: 2984 --LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEI 3041

Query: 919  REKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALR-------DALDQAQQ 971
             +K   + +  S   Q    L++  +      L  QL  T  +LR       D L+    
Sbjct: 3042 HQKELRIQQLNSNFSQ----LLEEKNT-----LSIQLCDTSQSLRENQQHYGDLLNHCAV 3092

Query: 972  VEKLMEAMRSCPDKAQTI-GNSGSANGIHQQDKAQK 1006
            +EK ++ +++ P       G     NG+H++   ++
Sbjct: 3093 LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEE 3128



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 126/606 (20%), Positives = 225/606 (37%), Gaps = 94/606 (15%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSH--ICEVEKEIALLKAQHEQYVAEAEE 412
            TALQE       H +  + E ++ R     ++S   I E+E+E+  ++ +  + V E E+
Sbjct: 2619 TALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678

Query: 413  KLQR--------------------------ARLLVES------VRKEKVDLSNQLEEERR 440
            KL++                          AR LVE       V KE   L+ Q++   R
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGR 2738

Query: 441  KVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPD 500
             +  LQ   +  +    +L+    A    + QL+E+  L R     L +          +
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNST--E 2796

Query: 501  HPDAAEILRLRERLLSASKEHQRESGVLRDKYE------KALKAYQAEVDKLRAANEKYA 554
                + + +L ++LLS  ++    S  L D Y       KA+ + Q E D L    EK+ 
Sbjct: 2797 ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR 2856

Query: 555  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK--EIG 612
            +   G K +     S +   + + K  + SL +D  + L++LK          Q+  E+ 
Sbjct: 2857 KSEEG-KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915

Query: 613  ELKAVMEGIK--------MEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGL 664
             LKA ++  +        M+ +L   NL  +H+L      K    + E+  + Q  +A  
Sbjct: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMA-- 2973

Query: 665  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 724
                        S    +L   Q+  R+      + + L V+Y+ QA      +   S  
Sbjct: 2974 -----------ISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASP----ETSASPD 3018

Query: 725  EKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETI 784
              + L YE  +    Q    ++ + +K L  +        L   ++T  I+  D S+   
Sbjct: 3019 GSQNLVYET-ELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR 3077

Query: 785  RTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEA 844
              ++    L +     +K+V  L +    +     A + K     K     L+E ++  +
Sbjct: 3078 ENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFS 3137

Query: 845  ELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLS------RE 898
            E +                 Q+L    + +NELR LL E        E  LS      R 
Sbjct: 3138 EAQ-----------------QQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR 3180

Query: 899  VHKAEW 904
            +  +EW
Sbjct: 3181 LEHSEW 3186



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 106/523 (20%), Positives = 216/523 (41%), Gaps = 86/523 (16%)

Query: 553  YAQE-VAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEI 611
            YA++ V  LKD ++Q   +     +  + +  +  +  +K     KA L S      K I
Sbjct: 56   YAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS----LNKYI 111

Query: 612  GELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH---- 667
             E+KA   G  +  + +     +KHD  +     E E ++ KLQE +E ++ LQ      
Sbjct: 112  EEMKA-QGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170

Query: 668  -------------------------------WRAQL-EVQASQHRLELQEAQDQRRDAEL 695
                                            +AQL + QA Q   ++   +D R + ++
Sbjct: 171  QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV 230

Query: 696  RVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVA 755
            R+HE E L +    QA     +++++ + ++K+ ++E      A   Q V+ L+++L  A
Sbjct: 231  RLHEDELLQLV--TQADVETEMQQKLRVLQRKLEEHEESLVGRA---QVVDLLQQELTAA 285

Query: 756  ENRLQAV-EALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKR-------DKEVTAL 807
            E R Q + + L   +  H    N +  E   +K  +E ++ ++ +R        +E+  L
Sbjct: 286  EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345

Query: 808  TSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQEL 867
              Q E      + LES+  + E+K  A ++EK      L+   ++   A   L   + +L
Sbjct: 346  LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405

Query: 868  LRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQK----------------- 910
            L+ +   NE  V   +  +      +  S+E+ +   R+  Q+                 
Sbjct: 406  LQDK---NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462

Query: 911  ---LKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALD 967
                +++I  L++++  L+ EK        +L+  S   E L+ +++ +S++  L +A +
Sbjct: 463  QAVTEENIASLQKRVVELENEKG-------ALLLSSIELEELKAENEKLSSQITLLEAQN 515

Query: 968  QAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1010
            +  + ++ +  + S  D A    +S   +G    +    Q+ K
Sbjct: 516  RTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHK 557


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  111 bits (277), Expect = 4e-24
 Identities = 154/705 (21%), Positives = 298/705 (42%), Gaps = 120/705 (17%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEVAKATSHICEVEKEIAL 398
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    +V   T    ++E+++  
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED----KVNTLTKAKIKLEQQVDD 1037

Query: 399  LKAQHEQY------VAEAEEKLQRARLLVES----VRKEKVDLSNQLEEERRKVEDLQFR 448
            L+   EQ       +  A+ KL+    L +     +  +K  L  +L+++  ++  LQ +
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097

Query: 449  VEEESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHS 494
            +E+E      L+      ++R+ +LEEE+   R               E+EE+ + L  +
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1157

Query: 495  GPPPP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA 549
            G         +    AE  ++R  L  A+ +H+  +  LR K+  ++     ++D L+  
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217

Query: 550  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLA--------------SDHQKSLED 595
             +K  +E + +K ++    S NM  +   K  L+ +                + Q+ + D
Sbjct: 1218 KQKLEKEKSEMKMEIDDLAS-NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276

Query: 596  L---KATLNSGPGAQQKEIGELKAVMEGI------------KMEHQLELGNLQAK----H 636
            L   +A L +  G   +++ E   ++  +            +++ QLE   ++AK    H
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE-EEIKAKSALAH 1335

Query: 637  DLETAMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEA 686
             L+++ H  + + LRE+ +E QE  A LQR           WR + E  A Q   EL+EA
Sbjct: 1336 ALQSSRH--DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEA 1393

Query: 687  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKMLDYERLQRAEAQGKQEV 745
               ++    R+ + E+       +  ++E  K+++ +  E  M+D ER   A A      
Sbjct: 1394 ---KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA------ 1444

Query: 746  ESLREKLLVAENRLQAVEALCSSQHTHM----IESNDISEETIRTKETVEGLQDKLNKRD 801
             +L +K    +  L   +  C   H  +     ES  +S E  + K   E   D+L    
Sbjct: 1445 -ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE--- 1500

Query: 802  KEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLV 861
                 L  + + L+ ++S L  +   G K++  L K K+++E E   +     +A   L 
Sbjct: 1501 ----TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 1556

Query: 862  LISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREK 921
                ++LR +  LN+++               ++ R++ + +  I + K ++ IR +   
Sbjct: 1557 HEEGKILRIQLELNQVK--------------SEVDRKIAEKDEEIDQMK-RNHIRIVESM 1601

Query: 922  LTGLDKE-KSLSDQRRYSLIDPSSAPEL-LRLQHQLMSTEDALRD 964
             + LD E +S +D  R          E+ ++L H      +ALR+
Sbjct: 1602 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1646



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 147/716 (20%), Positives = 293/716 (40%), Gaps = 148/716 (20%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI-------------------- 396
            LQ+ +KE Q  IE+L  E + ERA  AKA     ++ +E+                    
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167

Query: 397  --------------------------ALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVD 430
                                      A L+ +H   VAE  E++   + + + + KEK  
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK-- 1225

Query: 431  LSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQC 490
                  E + +++DL   +E  S  KG+LE    A + ++ +++ +        EE QQ 
Sbjct: 1226 -----SEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK--------EEEQQR 1272

Query: 491  LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR---ESGVLRDKYEKALKAYQAEVDKLR 547
            L++            ++   R RL + S E+ R   E   L  +  +  +A+  ++++L+
Sbjct: 1273 LIN------------DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK 1320

Query: 548  -------------------------AANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKL 582
                                        E+Y +E    K ++Q+A S+    +  W++K 
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA-KAELQRAMSKANSEVAQWRTKY 1379

Query: 583  DSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAM 642
            ++ A    + LE+ K  L     AQ+ +  E        K    LE    + ++++E  M
Sbjct: 1380 ETDAIQRTEELEEAKKKL-----AQRLQDAEEHVEAVNAKCA-SLEKTKQRLQNEVEDLM 1433

Query: 643  -HVKEKEALREKLQEAQEELAGLQRHWR-------AQLEVQASQHRLELQEAQDQRRDAE 694
              V+   A    L + Q     +   W+       A+LE    + R    E    +   E
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYE 1493

Query: 695  LRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLV 754
              + +LE L  E +   Q I  L EQI+   K++ + E++++   Q K E+++  E    
Sbjct: 1494 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE---- 1549

Query: 755  AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTAL-TSQTEM 813
                    EA  S +H    E   I    +   +    +  K+ ++D+E+  +  +   +
Sbjct: 1550 --------EAEASLEH----EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI 1597

Query: 814  LRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERS 873
            + +  S L+++ +S   + DA ++ K+++E +L  +  + + A+       +     +  
Sbjct: 1598 VESMQSTLDAEIRS---RNDA-IRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653

Query: 874  LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSD 933
            L + ++ L +A R     + DL  ++   E R     L+ +I  LR  L   ++ + +++
Sbjct: 1654 LKDTQLHLDDALR----SQEDLKEQLAMVERR--ANLLQAEIEELRATLEQTERSRKIAE 1707

Query: 934  QRRYSLIDPSSAPELLRLQH-QLMSTEDALRDALDQAQ-QVEKLMEAMRSCPDKAQ 987
            Q    L+D S   +LL  Q+  L++T+  L   + Q Q ++E +++  R+  +KA+
Sbjct: 1708 Q---ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAK 1760



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 156/739 (21%), Positives = 310/739 (41%), Gaps = 123/739 (16%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            + E   +   +++ T A ++ L+EK   + Q   + DL+    A+A S + + E+    L
Sbjct: 856  MKEEFEKTKEELAKTEAKRKELEEKMVTLMQ--EKNDLQLQVQAEADS-LADAEERCDQL 912

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
                 Q  A+ +E  +RA        +++ +++ +L  ++RK+ED    ++++     DL
Sbjct: 913  IKTKIQLEAKIKEVTERA--------EDEEEINAELTAKKRKLEDECSELKKDI---DDL 961

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
            ELT       + ++E+E      +++ L +                E+  L E +   +K
Sbjct: 962  ELT-------LAKVEKEKHATENKVKNLTE----------------EMAGLDETIAKLTK 998

Query: 520  EHQRESGVLRDKYEKALKAYQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMD 576
            E +     L++ +++ L   QAE DK   L  A  K  Q+V  L+  ++Q     M L +
Sbjct: 999  EKK----ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDL-E 1053

Query: 577  NWKSKLD---SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME---GIKMEHQLELG 630
              K KL+    LA +    +E+ K  L+     ++ E+  L++ +E    + M+ Q ++ 
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113

Query: 631  NLQAK-HDLETAMHV---------KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHR 680
             LQA+  +LE  +           K++  L  +L+E  E L        AQ+E+   +  
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE- 1172

Query: 681  LELQEAQDQRRDAELRVHELEKLDVEYRGQ-AQAIEFLKEQISLAEKKMLDYERLQRAEA 739
                E Q  RRD E    + E      R + A ++  L EQI   ++     ++L++ ++
Sbjct: 1173 ---AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK---QKLEKEKS 1226

Query: 740  QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIE-----------SNDISEETIRTKE 788
            + K E++ L   +         +E +C +    + E            ND++ +  R + 
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQT 1286

Query: 789  TVEGLQDKLNKRDKEVT-------ALTSQTEMLRAQV-------SALESKCKSGEKKVDA 834
                   +L+++D  V+       A T Q E L+ Q+       SAL    +S     D 
Sbjct: 1287 ESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDL 1346

Query: 835  L---LKEKRRLEAELETVSRKTHDASGQ--------LVLISQELLRKERSLNELRVLLLE 883
            L    +E++  +AEL+    K +    Q         +  ++EL   E +  +L   L +
Sbjct: 1347 LREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEEL---EEAKKKLAQRLQD 1403

Query: 884  ANRHSPGPE-RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSD--------- 933
            A  H      +  S E  K   + + + L  D+         LDK++   D         
Sbjct: 1404 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQK 1463

Query: 934  -QRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAM-RSCPDKAQTIGN 991
             +  ++ ++ +S  E   L  +L   ++A  ++LDQ + +++  + + +   D  + I  
Sbjct: 1464 CEETHAELE-ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1522

Query: 992  SGSANGIHQQDKAQKQEDK 1010
             G    IH+ +K +KQ ++
Sbjct: 1523 GGKR--IHELEKIKKQVEQ 1539



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 141/623 (22%), Positives = 259/623 (41%), Gaps = 103/623 (16%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I   +AL  AL+         ++Q+ E+  A+ +L+RA ++
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA-MS 1366

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA S + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426

Query: 440  RKVEDLQFRVEEESITKGDLELTT------VAE-KSRVLQLEEELTLRRGEIEELQQCLL 492
             +VEDL   VE  +     L+         +AE K +  +   EL   + E   L   L 
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486

Query: 493  HSGPPPPDHPDAAEILRLRERLL----SASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 548
                   +  D  E L+   + L    S   E   E G    + EK  K  + E  +L+A
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546

Query: 549  ANEKYAQEVAGLKDKV-------QQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN 601
            A E+    +   + K+        Q  SE    +     ++D +  +H + +E +++TL+
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606

Query: 602  SGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL-----------ETAMHVKEKE 648
            +   ++   I  LK  MEG   +ME QL   N  A   L           +T +H+ +  
Sbjct: 1607 AEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD-- 1663

Query: 649  ALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE-----AQDQRRDAELRVHEL-- 700
            ALR + ++ +E+LA ++R     Q E++  +  LE  E     A+ +  DA  RV  L  
Sbjct: 1664 ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722

Query: 701  ---------EKLDVEY---RGQAQAI--------EFLKEQISLAEKKMLDYERLQRAEAQ 740
                     +KL+ +    +G+ + I        E  K+ I+ A     + ++ Q   A 
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782

Query: 741  GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES---------NDISEETIRTKETVE 791
             ++  ++L + +   ++RL   E L        I+           ++  E  R  E V+
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842

Query: 792  GLQDKLNKRDKEVTALTSQTE--------------MLRAQVSALESKCKSGEKKVDALLK 837
            GL+    K +++V  LT QTE               L+A+V + + + +  E++ +  L 
Sbjct: 1843 GLR----KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLS 1898

Query: 838  EKRRLEAELETVSRKTHDASGQL 860
            + RR++ ELE    +   A  Q+
Sbjct: 1899 KFRRIQHELEEAEERADIAESQV 1921



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 64/305 (20%), Positives = 135/305 (44%), Gaps = 19/305 (6%)

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-------QASQHRLELQEAQDQR 690
            L++A   KE   ++E+ ++ +EELA  +   R +LE        + +  +L++Q   D  
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADSL 902

Query: 691  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 749
             DAE R  +L K  ++   + + + E  +++  +  +      +L+   ++ K++++ L 
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 805
              L   E    A E    +    M   ++    +++E    +E  +   D L   + +V 
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             LT     L  QV  LE   +  +K    L + KR+LE +L+     T D       + +
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDE 1082

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
            +L +KE  ++ L+  + +           L +++ + + RI+E  L+++I   R      
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALG----MQLQKKIKELQARIEE--LEEEIEAERASRAKA 1136

Query: 926  DKEKS 930
            +K++S
Sbjct: 1137 EKQRS 1141



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 54/221 (24%), Positives = 100/221 (45%), Gaps = 12/221 (5%)

Query: 762  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 821
            ++ L  S  T   E  ++ EE  +TKE +   + K  + ++++  L  +   L+ QV A 
Sbjct: 840  IKPLLKSAETEK-EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898

Query: 822  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 881
                   E++ D L+K K +LEA+++ V+ +  D       I+ EL  K+R L +    L
Sbjct: 899  ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSEL 954

Query: 882  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             +           + +E H  E ++K   L +++ GL E +  L KEK    +     +D
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012

Query: 942  PSSAPE-----LLRLQHQLMSTEDALRDALDQAQQVEKLME 977
               A E     L + + +L    D L  +L+Q +++   +E
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  110 bits (276), Expect = 5e-24
 Identities = 174/794 (21%), Positives = 333/794 (41%), Gaps = 161/794 (20%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     I+  T  ++AL+E  Q   Q L +  +E  +V   T    ++E+++  L
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQ---QTLDDLQMEEDKVNTLTKAKTKLEQQVDDL 1038

Query: 400  KAQHEQY------VAEAEEKLQRARLLVES----VRKEKVDLSNQLEEERRKVEDLQFRV 449
            +   EQ       +  A+ KL+    L +        +K  L+ +L+++  ++ +LQ ++
Sbjct: 1039 EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI 1098

Query: 450  EEESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSG 495
            E+E      L+      ++R+ +LEEE+   R               E+EE+ + L  +G
Sbjct: 1099 EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158

Query: 496  PPPP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAAN 550
                     +    AE  ++R  L  ++ +H+  +  LR K+  ++     ++D L+   
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVK 1218

Query: 551  EKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL-------------- 596
            +K  +E + LK ++    S NM  +   K+  + +    +  L ++              
Sbjct: 1219 QKLEKEKSELKMEINDLAS-NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277

Query: 597  ---KATLNSGPGAQQKEIGELKAVMEGI------------KMEHQLELGNLQAK----HD 637
               KA L++  G   +++ E  A++  +            +++ QLE    +AK    H 
Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE-EETKAKSTLAHA 1336

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQ 687
            L++A H  + + LRE+ +E QE  A LQR           WR + E  A Q   EL+EA+
Sbjct: 1337 LQSARH--DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 688  ----DQRRDAELRVH-------ELEK-------------LDVEYRGQAQAIEFLKEQIS- 722
                 + +DAE  V         LEK             +DVE R  A  I   K+Q + 
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE-RSNAACIALDKKQRNF 1453

Query: 723  ---LAEKKMLDYERLQRAEAQGKQEVESLREKLLVAEN----RLQAVEALCSSQHTHMIE 775
               LAE K   YE  Q      ++E  SL  +L   +N     L  +E L         E
Sbjct: 1454 DKVLAEWKQ-KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQE 1512

Query: 776  SNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE------------MLRAQV----- 818
             +D++E+     + +  L+    + D E + L +  E            +LR Q+     
Sbjct: 1513 ISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQV 1572

Query: 819  -SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNEL 877
             S ++ K    ++++D L +   R+   +++       +    + I +++   E  LNE+
Sbjct: 1573 KSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKM---EGDLNEM 1629

Query: 878  RVLLLEANRHSPGPERDL--------SREVH-----KAEWRIKEQ---------KLKDDI 915
             + L  ANR +    R+L          ++H     + +  +KEQ          ++ ++
Sbjct: 1630 EIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689

Query: 916  RGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH-QLMSTEDALRDALDQAQ-QVE 973
              LR  L   ++ + +++Q    L+D S   +LL  Q+  L++T+  L   + Q Q ++E
Sbjct: 1690 EELRASLERTERGRKMAEQ---ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746

Query: 974  KLMEAMRSCPDKAQ 987
             +++  R+  +KA+
Sbjct: 1747 DIVQEARNAEEKAK 1760



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 150/734 (20%), Positives = 299/734 (40%), Gaps = 115/734 (15%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            + E   +   +++ T A ++ L+EK   +  L+ E++  + +V      + + E+    L
Sbjct: 856  MKEEFEKTKEELAKTEAKRKELEEK---MVTLMQEKNDLQLQVQAEADALADAEERCDQL 912

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
                 Q  A+ +E  +RA        +++ +++ +L  ++RK+ED    ++++     DL
Sbjct: 913  IKTKIQLEAKIKEVTERA--------EDEEEINAELTAKKRKLEDECSELKKDI---DDL 961

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
            ELT       + ++E+E      +++ L +                E+  L E +   +K
Sbjct: 962  ELT-------LAKVEKEKHATENKVKNLTE----------------EMAGLDETIAKLTK 998

Query: 520  EHQRESGVLRDKYEKALKAYQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMD 576
            E +     L++ +++ L   Q E DK   L  A  K  Q+V  L+  ++Q     M L +
Sbjct: 999  EKK----ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL-E 1053

Query: 577  NWKSKLD---SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME---GIKMEHQLELG 630
              K KL+    LA +     E+ K  LN     ++ E+  L+  +E    + ++ Q ++ 
Sbjct: 1054 RAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK 1113

Query: 631  NLQAK-HDLETAMHV---------KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHR 680
             LQA+  +LE  +           K++  L  +L+E  E L        AQ+E+   +  
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE- 1172

Query: 681  LELQEAQDQRRDAELRVHELEKLDVEYRGQ-AQAIEFLKEQISLAEKKMLDYERLQRAEA 739
                E Q  RRD E    + E      R + A ++  L EQI   ++     ++L++ ++
Sbjct: 1173 ---AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVK---QKLEKEKS 1226

Query: 740  QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIE-----------SNDISEETIRTKE 788
            + K E+  L   +          E +C +    + E            N++S +  R   
Sbjct: 1227 ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHT 1286

Query: 789  TVEGLQDKLNKRDKEVT-------ALTSQTEMLRAQV-------SALESKCKSGEKKVDA 834
                   +L+++D  V+       A T Q E L+ Q+       S L    +S     D 
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDL 1346

Query: 835  L---LKEKRRLEAELET-VSRKTHDASGQLVLISQELLRKERSLNE----LRVLLLEANR 886
            L    +E++  +AEL+  +S+   + +        + +++   L E    L   L +A  
Sbjct: 1347 LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406

Query: 887  HSPG-PERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSD------QRRYSL 939
            H      +  S E  K   + + + L  D+         LDK++   D      +++Y  
Sbjct: 1407 HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEE 1466

Query: 940  ID---PSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAM-RSCPDKAQTIGNSGSA 995
                  +S  E   L  +L   ++A  ++LD  + +++  + + +   D  + I   G  
Sbjct: 1467 TQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG-- 1524

Query: 996  NGIHQQDKAQKQED 1009
              IH+ +K +KQ D
Sbjct: 1525 KHIHELEKVKKQLD 1538



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 129/599 (21%), Positives = 248/599 (41%), Gaps = 107/599 (17%)

Query: 356  ALQEALKE----KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            ALQ A  +    ++Q+ E+  A+ +L+R  ++KA S + +   +      Q  + + EA+
Sbjct: 1336 ALQSARHDCDLLREQYEEEQEAKAELQRG-MSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 412  EKL----QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT-------KGDLE 460
            +KL    Q A   VE+V  +   L    +  + +VEDL   VE  +         + + +
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454

Query: 461  LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILR----------- 509
                  K +  + + EL   + E   L   L        +  D  E L+           
Sbjct: 1455 KVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEIS 1514

Query: 510  -LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQAT 568
             L E++    K H  E   ++ + +      Q  +++  A+ E    ++  ++ ++ Q  
Sbjct: 1515 DLTEQIAEGGK-HIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573

Query: 569  SENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGI--KMEHQ 626
            SE    +     +LD L  +H + +E +++TL++   ++   +  +K  MEG   +ME Q
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL-RIKKKMEGDLNEMEIQ 1632

Query: 627  LELGNLQAKHDL-----------ETAMH----VKEKEALREKLQ-----------EAQEE 660
            L   N QA   L           +T +H    ++ ++ L+E+L            E +E 
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEEL 1692

Query: 661  LAGLQRHWR----AQLEVQASQHRLELQEAQDQ---------RRDAELRVHELEKLDVEY 707
             A L+R  R    A+ E+  +  R++L   Q+            D      E+E +  E 
Sbjct: 1693 RASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEA 1752

Query: 708  RG-QAQAIEFLKEQISLAEKKMLDYE---RLQRAEAQGKQEVESLREKLLVAEN------ 757
            R  + +A + + +   +AE+   + +    L+R +   +Q V+ L+ +L  AE       
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGG 1812

Query: 758  --RLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE--- 812
              ++Q +EA         +ES ++  E     E V+GL+    K ++ V  LT QTE   
Sbjct: 1813 KKQIQKLEA-----RVRELES-EVESEQKHNVEAVKGLR----KHERRVKELTYQTEEDR 1862

Query: 813  -----------MLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 860
                        L+ +V A + + +  E++ +  L + R+L+ ELE    +   A  Q+
Sbjct: 1863 KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQV 1921



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 64/305 (20%), Positives = 137/305 (44%), Gaps = 19/305 (6%)

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-------QASQHRLELQEAQDQR 690
            L++A   KE   ++E+ ++ +EELA  +   R +LE        + +  +L++Q   D  
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADAL 902

Query: 691  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 749
             DAE R  +L K  ++   + + + E  +++  +  +      +L+   ++ K++++ L 
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 805
              L   E    A E    +    M   ++    +++E    +E  +   D L   + +V 
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             LT     L  QV  LE   +  +K    L + KR+LE +L+     T D       +++
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE 1082

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
            +L +KE  ++ L+  + +    +      L +++ + + RI+E  L+++I   R      
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALA----IQLQKKIKELQARIEE--LEEEIEAERASRAKA 1136

Query: 926  DKEKS 930
            +K++S
Sbjct: 1137 EKQRS 1141



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 52/216 (24%), Positives = 97/216 (44%), Gaps = 12/216 (5%)

Query: 762  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 821
            ++ L  S  T   E  ++ EE  +TKE +   + K  + ++++  L  +   L+ QV A 
Sbjct: 840  IKPLLKSAETEK-EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898

Query: 822  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 881
                   E++ D L+K K +LEA+++ V+ +  D       I+ EL  K+R L +    L
Sbjct: 899  ADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSEL 954

Query: 882  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             +           + +E H  E ++K   L +++ GL E +  L KEK    +     +D
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012

Query: 942  PSSAPE-----LLRLQHQLMSTEDALRDALDQAQQV 972
                 E     L + + +L    D L  +L+Q +++
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKL 1048



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 8/140 (5%)

Query: 349  RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVA 408
            + I+    + E LK++Q     L  ER  +  E       +   E E   LK   +Q + 
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHL--ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ-IQ 1817

Query: 409  EAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKS 468
            + E +++     VES +K  V+    L +  R+V++L ++ EE+   K  L L  + +K 
Sbjct: 1818 KLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED--RKNILRLQDLVDK- 1874

Query: 469  RVLQLEEELTLRRGEIEELQ 488
              LQ + +   R+ E  E Q
Sbjct: 1875 --LQTKVKAYKRQAEEAEEQ 1892


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  110 bits (274), Expect = 9e-24
 Identities = 161/707 (22%), Positives = 304/707 (42%), Gaps = 103/707 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEVAKATSHICEVEKEIAL 398
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    +V   T    ++E+++  
Sbjct: 978  LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAKVKLEQQVDD 1033

Query: 399  LKAQHEQY------VAEAEEKLQR-ARLLVESV---RKEKVDLSNQLEEERRKVEDLQFR 448
            L+   EQ       +  A+ KL+   +L  ES+     +K  L  +L+++  ++  L  R
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093

Query: 449  VEEESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHS 494
            +E+E      L+      ++R+ +LEEEL   R               E+EE+ + L  +
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153

Query: 495  GPPPP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA 549
            G         +    AE  ++R  L  A+ +H+  +  LR K+  ++     ++D L+  
Sbjct: 1154 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213

Query: 550  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD--------------SLASDHQKSLED 595
             +K  +E +  K ++   TS NM  +   K+ L+              S A + Q+S+ D
Sbjct: 1214 KQKLEKEKSEFKLELDDVTS-NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272

Query: 596  L---KATLNSGPGAQQKEIGELKAVMEGI---KMEHQLELGNLQAK------------HD 637
            L   +A L +  G   +++ E +A++  +   K+ +  +L +L+ +            H 
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQ 687
            L++A H  + + LRE+ +E  E  A LQR           WR + E  A Q   EL+EA 
Sbjct: 1333 LQSARH--DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA- 1389

Query: 688  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKMLDYERLQRAEAQGKQEVE 746
              ++    R+ E E+       +  ++E  K ++ +  E  M+D ER   A A   ++  
Sbjct: 1390 --KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447

Query: 747  SLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTA 806
            +  +K+L      Q  E   S   +   E+  +S E  + K   E   + L    +E   
Sbjct: 1448 NF-DKILAEWK--QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE--- 1501

Query: 807  LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQE 866
                 + L+ ++S L  +  S  K +  L K +++LEAE   +     +A   L     +
Sbjct: 1502 ----NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK 1557

Query: 867  LLRKERSLNELRV----LLLEANRHSPGPERDLSREVHKAEWRI-KEQKLKDDIRGLREK 921
            +LR +   N+++      L E +      +R+  R V   +  +  E + +++   +++K
Sbjct: 1558 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617

Query: 922  LTG--LDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDAL 966
            + G   + E  LS   R +     +  ++  LQ  L  T+  L DA+
Sbjct: 1618 MEGDLNEMEIQLSHANRMA---AEAQKQVKSLQSLLKDTQIQLDDAV 1661



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 154/729 (21%), Positives = 290/729 (39%), Gaps = 129/729 (17%)

Query: 355  TALQEAL-------KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL---KAQHE 404
            T L+EAL       KE ++ +  LL E++  + +V     ++ + E+    L   K Q E
Sbjct: 857  TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916

Query: 405  QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTV 464
              V E  E+L+    +   +  +K  L ++  E +R ++DL+       +T   +E    
Sbjct: 917  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE-------LTLAKVEKEKH 969

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
            A +++V  L EE+                                L E +   +KE +  
Sbjct: 970  ATENKVKNLTEEMA------------------------------GLDEIIAKLTKEKK-- 997

Query: 525  SGVLRDKYEKALKAYQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK 581
               L++ +++AL   QAE DK   L  A  K  Q+V  L+  ++Q     M L +  K K
Sbjct: 998  --ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRK 1054

Query: 582  LDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH------QLELGNLQAK 635
            L+      Q+S+ DL+          +K+  EL A+   I+ E       Q +L  LQA+
Sbjct: 1055 LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQAR 1114

Query: 636  -----HDLETAMHVKEK-EALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQ 689
                  +LE     + K E LR  L    EE++           VQ   ++    E Q  
Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174

Query: 690  RRDAELRVHELEKLDVEYRGQ-AQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESL 748
            RRD E    + E      R + A ++  L EQI   ++     ++L++ +++ K E++ +
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK---QKLEKEKSEFKLELDDV 1231

Query: 749  REKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALT 808
               +         +E +C +    M E    +EET R+   +   + KL   + E++   
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL 1291

Query: 809  SQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTH---DASGQLVLISQ 865
             + E L +Q++    K    ++  D     KR+LE E++  +   H    A     L+ +
Sbjct: 1292 DEKEALISQLT--RGKLTYTQQLEDL----KRQLEEEVKAKNALAHALQSARHDCDLLRE 1345

Query: 866  ELLRKERSLNELRVLLLEANR---------HSPGPERDLSREVHKAEWRIKEQKLKDDIR 916
            +   +  +  EL+ +L +AN           +   +R    E  K +   + Q+ ++ + 
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405

Query: 917  GLREKLTGLDKEK-SLSDQRRYSLID---------------------------------- 941
             +  K + L+K K  L ++    ++D                                  
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465

Query: 942  --PSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMR-SCPDKAQTIGNSGSANGI 998
               SS  E   L  +L   ++A  ++L+  +  ++  + ++    D  + +G+SG    I
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT--I 1523

Query: 999  HQQDKAQKQ 1007
            H+ +K +KQ
Sbjct: 1524 HELEKVRKQ 1532



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 153/692 (22%), Positives = 288/692 (41%), Gaps = 88/692 (12%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            +E Q+ +  L ++R   + E  + +  + E E  I+ L      Y  + E+     R L 
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL---KRQLE 1320

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQ----LEEEL 477
            E V K K  L++ L+  R   + L+ + EEE+  K +L+       S V Q     E + 
Sbjct: 1321 EEV-KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1379

Query: 478  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEH-QRESGVLRDKYEK-- 534
              R  E+EE ++ L        +  +A E +  +   L  +K   Q E   L    E+  
Sbjct: 1380 IQRTEELEEAKKKLAQR---LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436

Query: 535  ----ALKAYQAEVDKLRAA-NEKYAQEVAGLKDKVQQATS---ENMGLMDNWKSKLDSLA 586
                AL   Q   DK+ A   +KY +  + L+   ++A S   E   L + ++  L+ L 
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496

Query: 587  S--DHQKSLEDLKATLNSGPGAQQKEIGELKAV---MEGIKMEHQLELGNLQAKHDLETA 641
            +     K+L++  + L    G+  K I EL+ V   +E  KME Q  L   +A  + E  
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556

Query: 642  MHVKE-------KEALREKLQEAQEELAGLQR-HWRAQLEVQASQHRLELQEAQDQRRDA 693
              ++        K  +  KL E  EE+   +R H R    +Q S       +A+ + R+ 
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL------DAETRSRNE 1610

Query: 694  ELRVH-----ELEKLDVEY----RGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQE 744
             LRV      +L +++++     R  A+A + +K   SL +   +  +   RA       
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN------ 1664

Query: 745  VESLREKLLVAENRLQAVEALCSSQHTHMIESNDIS-----EETIRTKETVEGLQDKLNK 799
             + L+E + + E R   ++A        ++E  + S     +E I T E V+ L  +   
Sbjct: 1665 -DDLKENIAIVERRNNLLQAELEELRA-VVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722

Query: 800  RDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQ 859
               +   + +    L+ +V     +C++ E+K    + +   +  EL    +K  D S  
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL----KKEQDTSAH 1778

Query: 860  LVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK--EQKLKDDIRG 917
            L  + + +   E+++ +L+  L EA + +    +   +++ K E R++  E +L+ + + 
Sbjct: 1779 LERMKKNM---EQTIKDLQHRLDEAEQIA---LKGGKKQLQKLEARVRELENELEAEQKR 1832

Query: 918  LREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLME 977
              E + G+ K +    +  Y          LLRLQ  +   +  ++    QA++ E+   
Sbjct: 1833 NAESVKGMRKSERRIKELTYQ--TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1890

Query: 978  AMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1009
               S   K Q           H+ D+A+++ D
Sbjct: 1891 TNLSKFRKVQ-----------HELDEAEERAD 1911



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 17/211 (8%)

Query: 775  ESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDA 834
            E   + EE  R KE +E  + +  + ++++ +L  +   L+ QV A +      E++ D 
Sbjct: 848  EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907

Query: 835  LLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERD 894
            L+K K +LEA+++ ++ +  D       ++ EL  K+R L +      E  R     E  
Sbjct: 908  LIKNKIQLEAKVKEMNERLEDEEE----MNAELTAKKRKLED---ECSELKRDIDDLELT 960

Query: 895  LS---REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE---- 947
            L+   +E H  E ++K   L +++ GL E +  L KEK    +     +D   A E    
Sbjct: 961  LAKVEKEKHATENKVK--NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018

Query: 948  -LLRLQHQLMSTEDALRDALDQAQQVEKLME 977
             L + + +L    D L  +L+Q ++V   +E
Sbjct: 1019 TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 39/196 (19%), Positives = 95/196 (48%), Gaps = 12/196 (6%)

Query: 796  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 855
            K  +R+KE+ ++  +   L+  +   E++ K  E+K+ +LL+EK  L+ +++       D
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900

Query: 856  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ--KLKD 913
            A  +   + +  ++ E  + E+   L +        E +++ E+   + +++++  +LK 
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERLED--------EEEMNAELTAKKRKLEDECSELKR 952

Query: 914  DIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE--LLRLQHQLMSTEDALRDALDQAQQ 971
            DI  L   L  ++KEK  ++ +  +L +  +  +  + +L  +  + ++A + ALD  Q 
Sbjct: 953  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012

Query: 972  VEKLMEAMRSCPDKAQ 987
             E  +  +     K +
Sbjct: 1013 EEDKVNTLTKAKVKLE 1028


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score =  110 bits (274), Expect = 9e-24
 Identities = 137/573 (23%), Positives = 251/573 (43%), Gaps = 75/573 (13%)

Query: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260
           SGS +S   S +     LR+G RV ++G    G V YVG T FA G+W GV LDE  GKN
Sbjct: 14  SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69

Query: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP-------------------AKAK 299
           DG V G +YF C    G+F      +V   G  +TSP                   AK  
Sbjct: 70  DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129

Query: 300 K--TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTE-------TSSRYARK 350
           K  T+  + GV+  + S   S  +S   ++SS    P+++ L          TS      
Sbjct: 130 KLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPP 189

Query: 351 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEA 410
           +   +  +E L+ + + +E+ L    L+RAE     + + E+EK     K Q EQ V E 
Sbjct: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAE---DKAKLKELEKH----KIQLEQ-VQEW 241

Query: 411 EEKLQRARLLVESVRKEKVDLSNQLEEERRK----VEDLQFRVEEESITKGDLELTTVAE 466
           + K+Q          +++ DL  +L+E R++    +E  +  +EE + T   +E+ T+ +
Sbjct: 242 KSKMQ----------EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDK 291

Query: 467 ---KSRVLQLEEELTLRRGEIEELQQCL--LHSGPPPPDHPDAAEILRLRERLLSASKEH 521
              + R   L++E+   +  ++EL   L  L +         AA   +L++  L      
Sbjct: 292 EMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ--LEEQNAR 349

Query: 522 QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK 581
            +++ V       + K    ++ KL     +  + V   ++++Q+  S+    +D  K +
Sbjct: 350 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 409

Query: 582 LDSL--ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQAKHDL 638
           +D+   A +  + L D    L       ++ +G+L+A+ E   +++       L+ +  L
Sbjct: 410 VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 469

Query: 639 ETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELR-- 696
           + A   + +EA +++++ AQE +A  Q+  +   ++ A    +  +    Q    E +  
Sbjct: 470 DMA-GARVREA-QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 527

Query: 697 ----VHELEKLDVEYRGQAQAIEFLKEQISLAE 725
                 + +    E +  A+AIE    Q+ +A+
Sbjct: 528 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 132/563 (23%), Positives = 228/563 (40%), Gaps = 83/563 (14%)

Query: 42  SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100
           S  H  S  PS S  +A A  +P                VG RV V G    G V Y+G 
Sbjct: 4   SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49

Query: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160
           T FA G+W GV+LD+  GKNDG V G +YF C    GIF R S++  Q   +G+ + +  
Sbjct: 50  TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107

Query: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLR 220
               +A  +    GT T   TS+ +P R +   S+   G  + S+L  SGS   GE    
Sbjct: 108 TPDSSASKVLKREGTDTTAKTSK-LPTRPA---STGVAG--ASSSLGPSGSASAGE---- 157

Query: 221 LGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFA 280
           L         +T +   +  T           L  P  + +G  A  R  +         
Sbjct: 158 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE--------- 208

Query: 281 PIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLL 340
              + +R+   +   AK K+ ++  + +  +    S                R      L
Sbjct: 209 EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEAL 267

Query: 341 TETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVAKATSHICEVEKEIA 397
            E   RY  +++ T  A++ A  +K+      +AE   E  + EV      + E+  ++ 
Sbjct: 268 -EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVEALKERVDELTTDLE 320

Query: 398 LLKA-----------------QHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR 440
           +LKA                 Q E+  A  ++ L R R L  S ++E V L   +E++ +
Sbjct: 321 ILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQ 380

Query: 441 KVEDLQFRVE--EESITKGDLELTTVAEKSRVL----QLEEELTLRRGEIEELQQCLLHS 494
           ++E ++ + E  +E +++ +  +  + E+        ++ E LT R   +EE  + L  +
Sbjct: 381 ELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET 440

Query: 495 GPPPPDHPDAAEILRLRERLLSASKEHQRE-------SGVLRDKYEKALKAYQAEVDKLR 547
                   D   +  + + L   ++E + E       +G    + +K ++A Q  V   +
Sbjct: 441 ------VGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQ 494

Query: 548 AANEKYAQEVAGLKDKVQQATSE 570
              +KY Q  A L+D  ++ T++
Sbjct: 495 QTIKKYRQLTAHLQDVNRELTNQ 517



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%)

Query: 715 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 773
           E L+ Q+   E+K L+  RL+RAE + K +E+E  + +L   +     ++   +     +
Sbjct: 198 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256

Query: 774 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 833
            E+   ++E +  KE      +++      +   T   EM   +  +L+ + ++ +++VD
Sbjct: 257 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313

Query: 834 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 880
            L  +   L+AE+E        +S QL  + ++  R + +L  +R L             
Sbjct: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373

Query: 881 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 932
           L+E         R     L  E+ +AE  I E K + D     E++  +  +++L+    
Sbjct: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433

Query: 933 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 985
             + R ++ D  +  E+   LQ     TE  LR+ LD A    ++ +K +E A  +  D 
Sbjct: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493

Query: 986 AQTI 989
            QTI
Sbjct: 494 QQTI 497


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  109 bits (273), Expect = 1e-23
 Identities = 159/717 (22%), Positives = 308/717 (42%), Gaps = 107/717 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  +  ++AL+E  QQ ++ L AE D    L +A+  K    + ++E 
Sbjct: 981  LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT-KLEQQVDDLEG 1039

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+     +  +K  L  +LE++  ++ +L  ++E+
Sbjct: 1040 SLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIED 1099

Query: 452  ESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSGPP 497
            E   +  L+      ++R+ +L EE+   R               E+EE+ + L  +G  
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1159

Query: 498  PPDHPDA-----AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEK 552
                 +      AE  +LR  L  A+ +H+     LR K+  ++     ++D L+   +K
Sbjct: 1160 TSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK 1219

Query: 553  YAQEVAGLKDKVQQATSENMGL-------------MDNWKSKLDSLASDHQKSLEDL--- 596
              +E + LK +    +S    +             +++  S+L +   + Q+ + DL   
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279

Query: 597  KATLNSGPGAQQKEIGELKAVMEGI------------KMEHQLELGNLQAK----HDLET 640
            +A L +  G   +++ E  A++  +            +++HQLE    +AK    H L++
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE-EETKAKNALAHALQS 1338

Query: 641  AMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQDQR 690
            + H  + + LRE+ +E QE  A LQR           WR + E  A Q   EL+EA   +
Sbjct: 1339 SRH--DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA---K 1393

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKMLDYERLQRAEAQGKQEVESLR 749
            +    R+ E E+       +  ++E  K+++ +  E  MLD ER   A A   ++  +  
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD 1453

Query: 750  EKLLVAENRLQAVEA-LCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALT 808
            + L   + + +  +A L +SQ     ES  +S E  + K   E   D+L         L 
Sbjct: 1454 KVLSEWKQKYEETQAELEASQK----ESRSLSTELFKVKNVYEESLDQLE-------TLR 1502

Query: 809  SQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELL 868
             + + L+ ++S L  +   G K++  L K K+++E E   +     +A   L     ++L
Sbjct: 1503 RENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562

Query: 869  RKERSLNELRV----LLLEANRHSPGPERDLSREVHKAEWRI-KEQKLKDDIRGLREKLT 923
            R +  LN+++      + E +      +R+ +R V   +  +  E + ++D   +++K+ 
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622

Query: 924  GLDKEKSLSDQRRYSLIDPSSAPELLR--------LQHQLMSTEDALRDALDQAQQV 972
            G   E  +       L     A E LR        L+   +  +DALR   D  +Q+
Sbjct: 1623 GDLNEMEIQLNHANRL-----AAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQL 1674



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 129/630 (20%), Positives = 253/630 (40%), Gaps = 101/630 (16%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL---KAQHEQYVAEAEEKLQRAR 418
            KE ++ +  LL E++  + +V      + + E+    L   K Q E  + E  E+ +   
Sbjct: 874  KELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEE 933

Query: 419  LLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELT 478
             +   +  +K  L ++  E ++ ++DL+       +T   +E    A +++V  L EE+ 
Sbjct: 934  EINAELTAKKRKLEDECSELKKDIDDLE-------LTLAKVEKEKHATENKVKNLTEEMA 986

Query: 479  LRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKA 538
                                           L E +   SKE +     L++ +++ L  
Sbjct: 987  ------------------------------GLDETIAKLSKEKK----ALQETHQQTLDD 1012

Query: 539  YQAEVDK---LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLED 595
             QAE DK   L  A  K  Q+V  L+  ++Q     M L +  K KL+      Q+S  D
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDL-ERAKRKLEGDLKLAQESTMD 1071

Query: 596  LKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQ 655
            +           + +  +L   +E    + + E+ NL +K + E A+ ++ ++ ++E LQ
Sbjct: 1072 M-----------ENDKQQLDEKLE----KKEFEISNLISKIEDEQAVEIQLQKKIKE-LQ 1115

Query: 656  EAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIE 715
               EEL           E++A   R    +A+ QR D    + E+ +   E  G   A  
Sbjct: 1116 ARIEELGE---------EIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSA-- 1162

Query: 716  FLKEQISLAEKKMLDYERLQR----AEAQGKQEVESLREKLLVAENRLQAVEALCSSQHT 771
                Q+ L +K+  ++++L+R    A  Q +  V +LR+K   A++  +  E + + Q  
Sbjct: 1163 ----QVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK--HADSMAELGEQIDNLQRV 1216

Query: 772  HMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKK 831
                   + +E    K   + L        K    L      L  QVS L++K +  ++ 
Sbjct: 1217 ----KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRL 1272

Query: 832  VDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGP 891
            ++ L  ++ RL+ E    SR+  +    +  +S+      + + EL+  L E  +     
Sbjct: 1273 INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNAL 1332

Query: 892  ERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRL 951
               L    H  +  +  ++ +++  G  E    L K  S   Q R          + ++ 
Sbjct: 1333 AHALQSSRHDCD--LLREQYEEEQEGKAELQRALSKANSEVAQWR-----TKYETDAIQR 1385

Query: 952  QHQLMSTEDALRDALDQAQQVEKLMEAMRS 981
              +L   E+A +    + Q+ E+ +EA+ +
Sbjct: 1386 TEEL---EEAKKKLAQRLQEAEEHVEAVNA 1412



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 111/546 (20%), Positives = 239/546 (43%), Gaps = 82/546 (15%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
            +L++  +  Q  +E L+ + +   A  A         +K ++  K ++E+  AE E   +
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK 1475

Query: 416  RARLL------VESVRKEKVDLSNQLEEERRKVEDLQFRVEE--ESITKGDLELTTVAEK 467
             +R L      V++V +E +D   QLE  RR+ ++LQ  + +  E I +G  ++  + + 
Sbjct: 1476 ESRSLSTELFKVKNVYEESLD---QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1532

Query: 468  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGV 527
             +  Q+E+E    +  +EE +  L H         +  +ILR+           Q E   
Sbjct: 1533 KK--QVEQEKCEIQAALEEAEASLEH---------EEGKILRI-----------QLELNQ 1570

Query: 528  LRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLAS 587
            ++ + ++ +     E+D+L+  + +  + +    D   ++ ++ + +    K K++    
Sbjct: 1571 VKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRV----KKKMEG--- 1623

Query: 588  DHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGN-LQAKHDLETAMHVKE 646
                 L +++  LN       + +   +   +GI  E QL L + L+ + DL+  + + E
Sbjct: 1624 ----DLNEMEIQLNHANRLAAESLRNYRNT-QGILKETQLHLDDALRGQEDLKEQLAIVE 1678

Query: 647  KEA--LREKLQEAQEELAGLQRHWR-AQLEVQASQHRLELQEAQDQ-----RRDAELRVH 698
            + A  L+ +++E    L   +R  + A+ E+  +  R++L   Q+      ++  E  V 
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738

Query: 699  ELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAEN 757
            +L+ +++   +    A E  K+ I+ A     + ++ Q   A  ++  ++L + +   ++
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1798

Query: 758  RLQAVEALCSSQHTHMIES---------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 808
            RL   E L        I+           ++  E  R  E V+GL+    K ++ V  LT
Sbjct: 1799 RLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR----KHERRVKELT 1854

Query: 809  SQTE--------------MLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTH 854
             QTE               L+A+V + + + +  E++ +A L + R+L+ ELE    +  
Sbjct: 1855 YQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERAD 1914

Query: 855  DASGQL 860
             A  Q+
Sbjct: 1915 IAESQV 1920



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 68/305 (22%), Positives = 134/305 (43%), Gaps = 19/305 (6%)

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-------QASQHRLELQEAQDQR 690
            L++A   KE   ++E+ Q+ ++ELA  +   R +LE        + +  +L++Q   D  
Sbjct: 843  LKSAETEKEMATMKEEFQKTKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQSEADSL 901

Query: 691  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 749
             DAE R  +L K  ++   + + + E  +E+  +  +      +L+   ++ K++++ L 
Sbjct: 902  ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLE 961

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 805
              L   E    A E    +    M   ++    +S+E    +ET +   D L   + +V 
Sbjct: 962  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 1021

Query: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865
             LT     L  QV  LE   +  +K    L + KR+LE +L+     T D       + +
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081

Query: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925
            +L +KE  ++     L+         E  L +++ + + RI+E  L ++I   R      
Sbjct: 1082 KLEKKEFEISN----LISKIEDEQAVEIQLQKKIKELQARIEE--LGEEIEAERASRAKA 1135

Query: 926  DKEKS 930
            +K++S
Sbjct: 1136 EKQRS 1140



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 112/493 (22%), Positives = 210/493 (42%), Gaps = 68/493 (13%)

Query: 515  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 574
            L  S E ++E   ++++++K         D+L  +  K  +    L++K+     E   L
Sbjct: 842  LLKSAETEKEMATMKEEFQKTK-------DELAKSEAKRKE----LEEKMVTLLKEKNDL 890

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ-----KEIGELKAVMEGIKMEHQLEL 629
                +S+ DSLA   ++  + +K  +      ++     +E  E+ A +   K + + E 
Sbjct: 891  QLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDEC 950

Query: 630  GNLQAKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEA 686
              L+   D   L  A   KEK A   K++   EE+AGL      +   + S+ +  LQE 
Sbjct: 951  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKLSKEKKALQET 1005

Query: 687  QDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAEAQG 741
              Q  D     E +V+ L K   +   Q   +E   EQ    EKK+ +D   L+RA+ + 
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ----EKKLRMD---LERAKRKL 1058

Query: 742  KQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE-GLQDKLNKR 800
            + +++  +E  +  EN  Q ++     +   +  SN IS+  I  ++ VE  LQ K+ + 
Sbjct: 1059 EGDLKLAQESTMDMENDKQQLDEKLEKKEFEI--SNLISK--IEDEQAVEIQLQKKIKEL 1114

Query: 801  DKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 860
               +  L  + E  RA  +  E              K++  L  ELE +S +  +A G  
Sbjct: 1115 QARIEELGEEIEAERASRAKAE--------------KQRSDLSRELEEISERLEEAGGAT 1160

Query: 861  VLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLRE 920
                +   ++E    +LR  L EA          L ++   +   + EQ   D+++ +++
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ--IDNLQRVKQ 1218

Query: 921  KLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQVEKL 975
            K   L+KEKS   + +    D SS  E +      L+    S ED + +   + ++ ++L
Sbjct: 1219 K---LEKEKS---ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRL 1272

Query: 976  MEAMRSCPDKAQT 988
            +  + +   + QT
Sbjct: 1273 INDLTAQRARLQT 1285


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  108 bits (271), Expect = 2e-23
 Identities = 152/680 (22%), Positives = 287/680 (42%), Gaps = 83/680 (12%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERA---EVAKATSHICEVEKE 395
            LTE  S     I+  T  ++AL+E  QQ ++ L AE D   +     +K    + ++E  
Sbjct: 979  LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038

Query: 396  IAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE 452
            +     L+   E+   + E  L+ A+  +  +  +K  L  +L+++  +   LQ +VE+E
Sbjct: 1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098

Query: 453  SITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHSGPPP 498
                   +      ++R+ +LEEE+   R               E+EEL + L  +G   
Sbjct: 1099 QTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT 1158

Query: 499  PDHPDA-----AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 553
                +      AE L+LR  L  A+ +H+     LR K+  ++     ++D L+   +K 
Sbjct: 1159 STQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKL 1218

Query: 554  AQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE 613
             +E +  K ++   +S +M  +   K+ L+ +     ++LED  +         Q+ + E
Sbjct: 1219 EKEKSEFKLEIDDLSS-SMESVSKSKANLEKIC----RTLEDQLSEARGKNEEIQRSLSE 1273

Query: 614  LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLE 673
            L       K   Q E G L  +        ++EKE++  +L  +++         + QLE
Sbjct: 1274 LTTQ----KSRLQTEAGELSRQ--------LEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321

Query: 674  VQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYER 733
             +           Q  R D +L   + E+   E  G+A+    L +  S   +    YE 
Sbjct: 1322 EENKAKNALAHALQSSRHDCDLLREQYEE---EQEGKAELQRALSKANSEVAQWRTKYET 1378

Query: 734  --LQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 791
              +QR E + ++  + L ++L  +E +++AV A C+S          + +   R +  VE
Sbjct: 1379 DAIQRTE-ELEEAKKKLAQRLQDSEEQVEAVNAKCAS----------LEKTKQRLQGEVE 1427

Query: 792  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 851
             L   + + +    AL  +       ++  ++KC+  + +++A LKE R L  EL  +  
Sbjct: 1428 DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKN 1487

Query: 852  KTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKL 911
               +A  QL  + +E    E+ + +L   + E             + +H+ E   K+ +L
Sbjct: 1488 AYEEALDQLETVKRENKNLEQEIADLTEQIAEN-----------GKTIHELEKSRKQIEL 1536

Query: 912  -KDDIR-GLREKLTGLDKEKS------LSDQRRYSLIDPSSA---PELLRLQHQLMSTED 960
             K DI+  L E    L+ E++      L   +  S ID   A    E+ +L+     T +
Sbjct: 1537 EKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 1596

Query: 961  ALRDALDQAQQVEKLMEAMR 980
             ++ ALD   +V    EA+R
Sbjct: 1597 TMQSALD--AEVRSRNEAIR 1614



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 140/658 (21%), Positives = 256/658 (38%), Gaps = 122/658 (18%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            +E Q+ + +L  ++   + E  + +  + E E  ++ L    + +  + EE  ++    +
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ----L 1320

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQ----LEEEL 477
            E   K K  L++ L+  R   + L+ + EEE   K +L+       S V Q     E + 
Sbjct: 1321 EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380

Query: 478  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRD------- 530
              R  E+EE ++ L        +  +A     +  +  S  K  QR  G + D       
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEA-----VNAKCASLEKTKQRLQGEVEDLMVDVER 1435

Query: 531  --KYEKALKAYQAEVDKLRA-----ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 583
                  AL   Q   DK+ A       E  A+  A LK+  +  ++E   L + ++  LD
Sbjct: 1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES-RSLSTELFKLKNAYEEALD 1494

Query: 584  SLAS--DHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH---QLELGNLQAKHDL 638
             L +     K+LE   A L        K I EL+   + I++E    QL L   +A  + 
Sbjct: 1495 QLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554

Query: 639  ETAMHVK-------EKEALREKLQEAQEELAGLQRHWRAQLEVQASQ------------- 678
            E A  ++        K  +  K+ E  EE+  L+R+++  +E   S              
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR 1614

Query: 679  ---------HRLELQEAQDQRRDAELRVH------ELEKLDVEYRGQAQAIEFLKEQISL 723
                     + +E+Q +   R+ AE   H      +L+   +      +  E LKEQ+++
Sbjct: 1615 LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAI 1674

Query: 724  AEKK----MLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 779
             E++      + E L+    Q ++  +   ++LL +  R+Q    L  +Q+T +I +   
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ----LLHTQNTSLIHTKKK 1730

Query: 780  SEETIRT--KETVEGLQDKLNKRDKEVTALTSQTEM--------------------LRAQ 817
             E  +     E  +  +D  N  +K   A+T    M                    L   
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790

Query: 818  VSALESKC--------KSGEKKVDALLKEKRRLEAELETVSRK-THDASG---------Q 859
            V  L+ +         K G+K++  L    R LE ELE   +K T    G         +
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850

Query: 860  LVLISQE----LLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKD 913
            L   S+E    +LR +  +++L+V +    R +   E D     H  ++R  + +L++
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQA--EEADEQANAHLTKFRKAQHELEE 1906



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 112/493 (22%), Positives = 204/493 (41%), Gaps = 68/493 (13%)

Query: 515  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 574
            L  S E ++E   ++++++K          K +   EK    V    D   Q  +E+  L
Sbjct: 840  LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
            +D  + + D L     K+   L+A +       + E  E+ A +   K + + E   L+ 
Sbjct: 900  LDA-EERCDQLI----KAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELKK 953

Query: 635  KHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR 691
              D   L  A   KEK A   K++   EEL+GL      +   + ++ +  LQEA  Q  
Sbjct: 954  DIDDLELTLAKVEKEKHATENKVKNLTEELSGLD-----ETIAKLTREKKALQEAHQQAL 1008

Query: 692  D----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAEAQGKQEVE 746
            D     E +V+ L K   +   Q + +E   EQ    EKK+ +D ER +R + +G  +++
Sbjct: 1009 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ----EKKLRVDLERNKR-KLEG--DLK 1061

Query: 747  SLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTA 806
              +E +L  EN  Q ++     +     +     E+     E   GLQ    K+ KE   
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED-----EQTLGLQ--FQKKIKE--- 1111

Query: 807  LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQE 866
                   L+A++  LE + ++         K++     ELE +S +  +A G  V  +Q 
Sbjct: 1112 -------LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG--VTSTQI 1162

Query: 867  LLRKERSLNELRVLLLEANRHSPGPERDLSREV--HKAEWRIKEQKLKDDIRGLREKLTG 924
             L K+R    L++             RDL      H+A      +K  D +  L E++  
Sbjct: 1163 ELNKKREAEFLKL------------RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN 1210

Query: 925  LDKEKSLSDQR----RYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQVEKL 975
            L + K   ++     +  + D SS+ E +      L+    + ED L +A  + +++++ 
Sbjct: 1211 LQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRS 1270

Query: 976  MEAMRSCPDKAQT 988
            +  + +   + QT
Sbjct: 1271 LSELTTQKSRLQT 1283



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 51/221 (23%), Positives = 99/221 (44%), Gaps = 12/221 (5%)

Query: 762  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 821
            ++ L  S  T   E   + EE  +TK+ +   + K  + ++++  L  +   L+ QV A 
Sbjct: 837  IKPLLKSAETEK-EMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895

Query: 822  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 881
                   E++ D L+K K +LEA+++ V+ +  D       I+ EL  K+R L +    L
Sbjct: 896  SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSEL 951

Query: 882  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             +           + +E H  E ++K   L +++ GL E +  L +EK    +     +D
Sbjct: 952  KKDIDDLELTLAKVEKEKHATENKVK--NLTEELSGLDETIAKLTREKKALQEAHQQALD 1009

Query: 942  PSSAPE-----LLRLQHQLMSTEDALRDALDQAQQVEKLME 977
               A E     L + + +L    + L  +L+Q +++   +E
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 88/402 (21%), Positives = 165/402 (41%), Gaps = 66/402 (16%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK--EIA 397
            LT+  S   RKI+          EK + IEQL  +R+ +R      ++   EV    E  
Sbjct: 1566 LTQVKSEIDRKIA----------EKDEEIEQL--KRNYQRTVETMQSALDAEVRSRNEAI 1613

Query: 398  LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKG 457
             LK + E  + E E +L  A        ++  +    L   + +++D Q  +++    + 
Sbjct: 1614 RLKKKMEGDLNEIEIQLSHAN-------RQAAETLKHLRSVQGQLKDTQLHLDDALRGQE 1666

Query: 458  DL--ELTTVAEKSRVLQLE-EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER- 513
            DL  +L  V  ++ +LQ E EEL   R  +E+ ++    +     D  +  ++L  +   
Sbjct: 1667 DLKEQLAIVERRANLLQAEVEEL---RATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723

Query: 514  LLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMG 573
            L+   K+ + +   L+ + E A +  +   +K + A    A     LK   +Q TS ++ 
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK--EQDTSAHLE 1781

Query: 574  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEI------------GELKAVMEGI 621
             M   K  L+    D Q  L++ +     G   Q +++            GE K   E +
Sbjct: 1782 RM---KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESV 1838

Query: 622  K-------------MEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHW 668
            K              + + +  N+    DL   + VK K   R+  +  ++  A L +  
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR 1898

Query: 669  RAQLEVQASQHRLELQEAQDQRRDAELR--------VHELEK 702
            +AQ E++ ++ R ++ E+Q  +  A+ R        VHE E+
Sbjct: 1899 KAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  107 bits (267), Expect = 6e-23
 Identities = 156/707 (22%), Positives = 302/707 (42%), Gaps = 103/707 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     I+  T  ++AL+E  Q   Q L +  +E  +V   +    ++E+++  L
Sbjct: 980  LTEEMAGLDEIIAKLTKEKKALQEAHQ---QALDDLQVEEDKVNSLSKSKVKLEQQVDDL 1036

Query: 400  KAQHEQYVAEAEEKLQRARLLVES----VRKEKVDLSN---QLEEERRKVE----DLQFR 448
            +   EQ   +    L+RA+  +E      ++  +DL N   QLEE+ +K E        +
Sbjct: 1037 EGSLEQE-KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSK 1095

Query: 449  VEEESITKGDLELTTVAEKSRVLQLEEELTLRRG--------------EIEELQQCLLHS 494
            +E+E +    L+      ++R+ +LEEEL   R               E+EE+ + L  +
Sbjct: 1096 IEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1155

Query: 495  GPPPP-----DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA 549
            G         +    AE  ++R  L  A+ +H+  +  LR K+  ++     ++D L+  
Sbjct: 1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1215

Query: 550  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLA--------------SDHQKSLED 595
             +K  +E +  K ++   TS NM  +   K+ L+ ++               + Q+SL D
Sbjct: 1216 KQKLEKEKSEFKLELDDVTS-NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLND 1274

Query: 596  L---KATLNSGPGAQQKEIGELKAVMEGI---KMEHQLELGNLQAK------------HD 637
                +A L +  G   +++ E +A++  +   K+ +  ++ +L+ +            H 
Sbjct: 1275 FTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA 1334

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQ 687
            L++A H  + + LRE+ +E  E  A LQR           WR + E  A Q   EL+EA 
Sbjct: 1335 LQSARH--DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA- 1391

Query: 688  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKMLDYERLQRAEAQGKQEVE 746
              ++    R+ + E+       +  ++E  K ++ +  E  M+D ER   A A   ++  
Sbjct: 1392 --KKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449

Query: 747  SLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTA 806
            +  +K+L      Q  E   S   +   E+  +S E  + K   E   + L    +E   
Sbjct: 1450 NF-DKILAEWK--QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE--- 1503

Query: 807  LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQE 866
                 + L+ ++S L  +   G K V  L K +++LE E   +     +A   L     +
Sbjct: 1504 ----NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGK 1559

Query: 867  LLRKERSLNELRV----LLLEANRHSPGPERDLSREVHKAEWRI-KEQKLKDDIRGLREK 921
            +LR +   N+++      L E +      +R+  R V   +  +  E + ++++  +++K
Sbjct: 1560 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKK 1619

Query: 922  LTG--LDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDAL 966
            + G   + E  LS   R +     +  ++  LQ  L  T+  L DA+
Sbjct: 1620 MEGDLNEMEIQLSHANRMA---AEAQKQVKSLQSLLKDTQIQLDDAV 1663



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 161/780 (20%), Positives = 318/780 (40%), Gaps = 128/780 (16%)

Query: 309  SALTHSPSSSSI-----SSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE 363
            + L H  +++++      SV+ +   +         L +  S +  ++   T+  E + +
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242

Query: 364  KQQHIEQLLAERDLE------RAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEK---- 413
             + ++E++   R LE      R ++ +A   + +   + A L+ ++ +   + EEK    
Sbjct: 1243 AKANLEKV--SRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI 1300

Query: 414  --LQRARLLVESVRKEKVDLSNQLEEE--------------RRKVEDLQFRVEEESITKG 457
              L R +L   S  ++  DL  QLEEE              R   + L+ + EEE+  K 
Sbjct: 1301 SQLTRGKL---SYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKA 1357

Query: 458  DLELTTVAEKSRVLQ----LEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER 513
            +L+       S V Q     E +   R  E+EE ++ L        D  +A E +  +  
Sbjct: 1358 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR---LQDAEEAVEAVNAKCS 1414

Query: 514  LLSASKEH-QRESGVLRDKYEK------ALKAYQAEVDKLRAA-NEKYAQEVAGLKDKVQ 565
             L  +K   Q E   L    E+      AL   Q   DK+ A   +KY +  + L+   +
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474

Query: 566  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 625
            +A S +        ++L  L + +++SLE L+         Q++     + + EG K  H
Sbjct: 1475 EARSLS--------TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH 1526

Query: 626  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQ-RHWRAQLEVQASQHRLEL- 683
            +LE    + +  LE      EK  L+  L+EA+  L   + +  RAQLE    +  +E  
Sbjct: 1527 ELE----KVRKQLEV-----EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577

Query: 684  -----QEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRA 737
                 +E +  +R+ +  V  L+  LD E R + + +   K+      +  +      R 
Sbjct: 1578 LAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRM 1637

Query: 738  EAQGKQEVESL---------------------REKLLVAENRLQAVEALCSSQHTHMIES 776
             A+ +++V+SL                     +E + + E R   ++A        ++E 
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA-VVEQ 1696

Query: 777  NDIS-----EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKK 831
             + S     +E I T E V+ L  +      +   + S    L+++V     +C++ E+K
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756

Query: 832  VDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGP 891
                + +   +  EL    +K  D S  L  + + +   E+++ +L+  L EA + +   
Sbjct: 1757 AKKAITDAAMMAEEL----KKEQDTSAHLERMKKNM---EQTIKDLQHRLDEAEQIA--- 1806

Query: 892  ERDLSREVHKAEWRIK--EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 949
             +   +++ K E R++  E +L+ + +   E + G+ K +    +  Y   +      LL
Sbjct: 1807 LKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKK--NLL 1864

Query: 950  RLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1009
            RLQ  +   +  ++    QA++ E+      S   K Q           H+ D+A+++ D
Sbjct: 1865 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ-----------HELDEAEERAD 1913



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 144/697 (20%), Positives = 288/697 (41%), Gaps = 107/697 (15%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL---KAQHEQYVAEAEEKLQRAR 418
            KE ++ +  LL E++  + +V     ++ + E+    L   K Q E  V E  E+L+   
Sbjct: 873  KELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEE 932

Query: 419  LLVESVRKEKVDLSNQLEEERRKVEDLQF---RVEEESITKGDLELTTVAEKSRVLQLEE 475
             +   +  +K  L ++  E ++ ++DL+    +VE+E     +       E + + ++  
Sbjct: 933  EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992

Query: 476  ELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR--------ERLLSASKEHQRESGV 527
            +LT  +  ++E  Q  L       D  ++    +++        E  L   K+ + +   
Sbjct: 993  KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052

Query: 528  LRDKYEKALKAYQAEV-----------DKLRAANEKYAQEVAGLKD------KVQQATSE 570
             + K E  LK  Q  +           +KL+       Q+ + ++D      ++Q+   E
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKE 1112

Query: 571  NMGLMDNW----------KSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIG-ELKAVME 619
            N   ++            ++K++ L SD  + LE++   L    GA   +I    K   E
Sbjct: 1113 NQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1172

Query: 620  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQH 679
              KM   LE   LQ +    TA  +++K A  + + E  E++  LQR  + +LE + S+ 
Sbjct: 1173 FQKMRRDLEEATLQHE---ATAAALRKKHA--DSVAELGEQIDNLQR-VKQKLEKEKSEF 1226

Query: 680  RLELQEA---------------------QDQRRDAELRVHELEKLDVEYRGQAQAIEFLK 718
            +LEL +                      +DQ  +  +++ E ++   ++  Q   ++   
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286

Query: 719  EQIS--LAEKKMLDYERLQRAEAQGKQEVESLREKLL---VAENRLQAVEALCSSQHTHM 773
             +++  L EK+ L   +L R +    Q++E L+ +L     A+N L    AL S++H   
Sbjct: 1287 GELARQLEEKEAL-ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL--AHALQSARHDCD 1343

Query: 774  IESNDISEETIRTKETVEGLQDKLNK-----RDKEVTALTSQTEMLRAQVSALESKCKSG 828
            +      EET   K  ++ +  K N      R K  T    +TE L      L  + +  
Sbjct: 1344 LLREQYEEET-EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1402

Query: 829  EKKVDA-------LLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 881
            E+ V+A       L K K RL+ E+E +      ++     + ++    ++ L E +   
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462

Query: 882  LEAN---RHSPGPERDLSREVHKAEWRIKE-----QKLKDDIRGLREKLTGLDKEKSLSD 933
             E+      S    R LS E+ K +   +E     +  K + + L+E+++ L ++     
Sbjct: 1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGG 1522

Query: 934  QRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQ 970
            +         +  EL +++ QL   +  L+ AL++A+
Sbjct: 1523 K---------NVHELEKVRKQLEVEKLELQSALEEAE 1550



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 75/322 (23%), Positives = 141/322 (43%), Gaps = 41/322 (12%)

Query: 688  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQR------AEAQG 741
            D R+  E  +  L+    +Y+     + F    + L E+ M D ERL R      A+A+G
Sbjct: 739  DSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEE-MRD-ERLSRIITRMQAQARG 796

Query: 742  K------QEVESLREKLLVAENRLQA---------------VEALCSSQHTHMIESNDIS 780
            +      +++   R+ LLV +  ++A               ++ L  S  T   E   + 
Sbjct: 797  QLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEK-EMATMK 855

Query: 781  EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 840
            EE  R KET+E  + +  + ++++ +L  +   L+ QV A +      E++ D L+K K 
Sbjct: 856  EEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915

Query: 841  RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 900
            +LEA+++ ++ +  D       ++ EL  K+R L +    L +           + +E H
Sbjct: 916  QLEAKVKEMNERLEDEEE----MNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971

Query: 901  KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE-----LLRLQHQL 955
              E ++K   L +++ GL E +  L KEK    +     +D     E     L + + +L
Sbjct: 972  ATENKVK--NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKL 1029

Query: 956  MSTEDALRDALDQAQQVEKLME 977
                D L  +L+Q ++V   +E
Sbjct: 1030 EQQVDDLEGSLEQEKKVRMDLE 1051



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 77/384 (20%), Positives = 159/384 (41%), Gaps = 40/384 (10%)

Query: 634  AKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDA 693
            A+ + E A   +E   ++E L++++     L+    + L+ + +  +L++Q  QD   DA
Sbjct: 845  AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQ-EKNDLQLQVQAEQDNLNDA 903

Query: 694  ELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKL 752
            E R  +L K  ++   + + + E L+++  +  +      +L+   ++ K++++ L   L
Sbjct: 904  EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTL 963

Query: 753  LVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQ----DKLNKRDKEVTALT 808
               E    A E    +    M   ++I  +  + K+ ++       D L   + +V +L+
Sbjct: 964  AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLS 1023

Query: 809  SQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELL 868
                 L  QV  LE   +  +K    L + KR+LE +L+       D     + + ++L 
Sbjct: 1024 KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083

Query: 869  RKERSLNELRVLL---------------------------LEANRHSPGP----ERDLSR 897
            +KE  +N+    +                           LEA R +         DLSR
Sbjct: 1084 KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSR 1143

Query: 898  EVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
            E+ +   R++E      ++    K    + +K   D    +L   ++A   LR +H    
Sbjct: 1144 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA-AALRKKHADSV 1202

Query: 958  TEDALRDALDQAQQVEKLMEAMRS 981
             E  L + +D  Q+V++ +E  +S
Sbjct: 1203 AE--LGEQIDNLQRVKQKLEKEKS 1224


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  105 bits (263), Expect = 2e-22
 Identities = 163/748 (21%), Positives = 332/748 (44%), Gaps = 99/748 (13%)

Query: 337  SGLLTETSSRYARKISGTTALQEALKEKQQ-HIEQLLAERDLERAEVAKATSHICEVEKE 395
            S L+T+  S     IS  +  +E L++  Q H  +L A+     +E+    + I + ++E
Sbjct: 465  SSLITDLQS----SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520

Query: 396  IALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT 455
            +A LK Q ++  A+  + LQ+     + +R +   LS+ L+++ ++++++    E++  T
Sbjct: 521  LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV---AEKQEAT 577

Query: 456  KGD--LELTTVAEKSRVLQLEEELTLRR---------GEIEELQQCLLHSGPPPPD---- 500
            + D   +L T AE+      E +  L++          ++E LQQ L  +          
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637

Query: 501  ----HPDAAEILRLRERL---LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 553
                  + AE+ R  E L   +  +++ Q E+     + E  L++ Q +  +     E+ 
Sbjct: 638  VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE----KERV 693

Query: 554  AQEVAGLKDKVQ---QATSENMGLMDNWKSKLDSLASDHQKSLEDLKA---TLNSGPGAQ 607
            AQE   L++++Q   ++     G ++  K +      + Q+ + +LKA   +L      +
Sbjct: 694  AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753

Query: 608  QKEIGELKAVMEGIKME-------HQLELGNLQ--------AKHDLETAMH--VKEKEAL 650
            +KE+ E +A  +G++         HQ E   L+        A+H  E+     VKE  A 
Sbjct: 754  RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813

Query: 651  REKLQEAQEELAGLQRHWRAQ---LEVQASQHRLELQEAQDQ----RRDAELRV-HELEK 702
            RE+ +++Q+E A     ++ Q   L+ +  + R ELQEA+++       +EL++  +  +
Sbjct: 814  RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873

Query: 703  LDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR-------EKLLVA 755
            L   +   A+A++ ++E+   A+K   D   LQ   A   +EV  L        E+   A
Sbjct: 874  LAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933

Query: 756  ENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLR 815
               L    A    +    +E      +   T+  ++ ++ +  +   E+  L  +  ++ 
Sbjct: 934  SRELVKEPARAGDRQPEWLEEQQ-GRQFCSTQAALQAMEREAEQMGNELERL--RAALME 990

Query: 816  AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKER-SL 874
            +Q    E + +  E++V  L +E+ R +A+L         A  +L +  Q  L ++R   
Sbjct: 991  SQGQQQEERGQQ-EREVARLTQERGRAQADLALEKA----ARAELEMRLQNALNEQRVEF 1045

Query: 875  NELRVLLLEANRHSPGPERDLSREVHKAEWRIKE-QKLKDDIRGLREKLTGLDKEKSLSD 933
              L+  L  A     G +++L++       +IKE ++L+  ++ L+E+L   +KE +   
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105

Query: 934  --QRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRS---------- 981
              Q   +     + P+L  L+ ++   E   +   +QA  +E+ +EA R+          
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165

Query: 982  -----CPDKAQTIGNSGSANGIHQQDKA 1004
                   +KAQ +G+S SA    Q++ A
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELA 1193



 Score =  103 bits (257), Expect = 8e-22
 Identities = 173/715 (24%), Positives = 311/715 (43%), Gaps = 135/715 (18%)

Query: 352  SGTTALQEALKEKQQ---HIEQLLAERDLERAEVAKATSHICEVEKEIAL--LKAQHEQY 406
            S  T++ +A +EK +    +E+L A  +  R E  +A + + E+E ++     KA  ++ 
Sbjct: 633  SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692

Query: 407  VAEAEEKLQ-RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVA 465
            VA+ +++LQ + + L ES++  K      LEEE+R+  D     ++  I++   E  ++ 
Sbjct: 693  VAQEKDQLQEQLQALKESLKVTK----GSLEEEKRRAADA-LEEQQRCISELKAETRSLV 747

Query: 466  E--KSRVLQLEEELTLRRGEIEELQQC-LLHSGPPPPDHPDAAEILRLRERLLSASKEHQ 522
            E  K    +LEEE   R+G    LQQ    H         + AE +  +    S  ++  
Sbjct: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807

Query: 523  RESGVLRDKYEKALK-------AYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLM 575
            +E    R++YE + +        +Q ++  L+   EK  QE+   K+KV    S +   +
Sbjct: 808  KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI 867

Query: 576  DNWKSKLDSLASDHQKSLEDLK-------------ATLNSGPGAQQKEIGELKAVMEGIK 622
               +++L  L ++  ++L+ ++             +TL     A  KE+  L+ ++    
Sbjct: 868  SRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR--- 924

Query: 623  MEHQLELGNLQAKHDLETAMH--VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHR 680
                      +A    ETA    VKE     ++  E  EE  G Q     Q  +QA +  
Sbjct: 925  ----------KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQ-FCSTQAALQAMERE 973

Query: 681  LE------------LQEAQDQRRDAE-LRVHELEKLDVEYRGQAQAIEFLKEQISLAEKK 727
             E            L E+Q Q+++    +  E+ +L  E RG+AQA +   E+ + AE +
Sbjct: 974  AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE-RGRAQA-DLALEKAARAELE 1031

Query: 728  MLDYERLQRAEAQGKQEVESLREKLLVA----ENRLQAVEALCSSQHTHMIESNDISEET 783
            M    RLQ A  + + E  +L+E L  A    E + Q +  L   +   + E  ++    
Sbjct: 1032 M----RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL---- 1083

Query: 784  IRTKETVEGLQDKLNKRDK----------EVTALTSQT----EMLRAQVSALESKCKSGE 829
               ++TV+ L+++L K++K          E    T  T    E LRA+VS LE +C+  +
Sbjct: 1084 ---RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140

Query: 830  KKVDALLKEKRRLEAELETVSRKTHDAS-----GQLVLISQELLRKERSL----NELRVL 880
            ++ D+L   +R LEA  E  SR   D++     GQL   +QEL   + +L     EL   
Sbjct: 1141 EQADSL---ERSLEA--ERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195

Query: 881  LLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLI 940
              +   HS   +          EW+ +  + + +       ++ L++E S+ +  R  L 
Sbjct: 1196 RTKVQDHSKAED----------EWKAQVARGRQEAERKNSLISSLEEEVSILN--RQVLE 1243

Query: 941  DPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSA 995
                + EL RL              + ++++ +KL E +R    +A+T  NS  A
Sbjct: 1244 KEGESKELKRL-------------VMAESEKSQKLEERLRLL--QAETASNSARA 1283



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 155/704 (22%), Positives = 281/704 (39%), Gaps = 93/704 (13%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            L+ AL E Q   ++   ER  +  EVA+ T      + ++AL KA      AE E +LQ 
Sbjct: 984  LRAALMESQGQQQE---ERGQQEREVARLTQERGRAQADLALEKAAR----AELEMRLQN 1036

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAE----KSRVLQ 472
            A      + +++V+ +   E     + + + + +E +  +G LE   + E    +  V Q
Sbjct: 1037 A------LNEQRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQ 1089

Query: 473  LEEELTLRRGEIEELQQCLLHS-GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDK 531
            L+E+L  +  E          + G   P  P   E LR     L    + Q+E     ++
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL-EALRAEVSKLEQQCQKQQEQADSLER 1148

Query: 532  YEKALKAYQAEVDK----LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLAS 587
              +A +A +AE D     L+   E+ AQE+   +  +  A  E    +  +++K+     
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE----LAAFRTKVQ---- 1200

Query: 588  DHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEK 647
            DH K+ ++ KA +  G    +++   + ++ E + + ++  L       +L+  +  +  
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAES- 1259

Query: 648  EALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEY 707
                EK Q+ +E L  LQ    +     A +     +E Q  R +AE +    E L  E 
Sbjct: 1260 ----EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315

Query: 708  RGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAEN---RLQAVEA 764
              QA+  E L +++   ++K    E+            ++L  +LL A++   +LQA +A
Sbjct: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA 1375

Query: 765  LCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTAL----------TSQTEML 814
                +H          EE  ++K+   GL+ +L +  +E+  L              + L
Sbjct: 1376 AAEKRH---------REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQL 1426

Query: 815  RAQVSALESKCKSGEKKVDALLKEKRR------------LEAELETVSRK--------TH 854
            RA+ ++   +  S  KK   LL E+ R            LE EL+    K          
Sbjct: 1427 RAEKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485

Query: 855  DASGQLVLISQELLRKERSLNEL-------RVLLLEANRHSPGPERDLSREVHKAEWRIK 907
            DA  +L  + +E     R L  +       +V +LE  +      + L+ +V + E   +
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545

Query: 908  EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSL--IDPSSAPELLRLQHQLMSTEDALRDA 965
            EQ     +  L +KL   D+   +  Q+  ++      S  E  RLQ QL   +  L   
Sbjct: 1546 EQ--TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK 1603

Query: 966  LDQAQQVEKLMEAMRSCPD--KAQTIGNSGSANGIHQQDKAQKQ 1007
               A+  +  ME  ++  D  K Q          + Q  K  K+
Sbjct: 1604 EQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 169/803 (21%), Positives = 305/803 (37%), Gaps = 189/803 (23%)

Query: 379  RAEVAKATSHICEVEKEIA---LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL 435
            + ++A   S+  E+E E+A    L  + +  +A  ++++ R  LL E      ++   +L
Sbjct: 220  KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE-PKEL 278

Query: 436  EEERRKVEDLQFRVEEE---------------------SITKGDLELTTVAEKSRVLQLE 474
            EE R K E L  R+ E                      S   GDL        S + QL+
Sbjct: 279  EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338

Query: 475  E---ELTLRRGE-----IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEH----- 521
            +   ELT    +     +E+  Q          D     E   + +  LS  +EH     
Sbjct: 339  DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398

Query: 522  ----QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSE---NMGL 574
                Q +  VL D  +  L+  + E   L A N +    V  L+ +  Q  ++     G 
Sbjct: 399  DNPPQEKGEVLGDVLQ--LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
             +  K +L SL +D Q S+ +L         A Q     L A +  +  E       +Q 
Sbjct: 457  FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ- 515

Query: 635  KHDLETA---MHVKEKEA-LREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD-- 688
            + D E A      KEK+A L + LQ+ ++   GL RH   QL     Q   +L+E  +  
Sbjct: 516  QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL-RHQVEQLSSSLKQKEQQLKEVAEKQ 574

Query: 689  ---------------QRRDAELRVHE--LEKLDVEYRGQAQAIEFLKEQISLA----EKK 727
                           + R+A LR  +  L++L+   + +A  +E L++Q+ +A    +  
Sbjct: 575  EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634

Query: 728  MLDYERLQRAEAQGKQEVESLR--------------------------------EKLLVA 755
                 + QR +A+  ++VE L+                                EK  VA
Sbjct: 635  QTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA 694

Query: 756  ENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQ----- 810
            + + Q  E L + + +  +    + EE  R  + +E  Q  +++   E  +L  Q     
Sbjct: 695  QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754

Query: 811  ---------------------------TEMLRAQVSALESKCKSGEKKVDALLKE----K 839
                                       TE+LR +++   +   + E + + L+KE    +
Sbjct: 755  KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814

Query: 840  RRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV 899
             R E   +  ++       QL+ + +E  +  + L E +  +     HS   E  +SR+ 
Sbjct: 815  ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS---ELQISRQQ 871

Query: 900  HK---------------AEWRIKEQKLKDDIRGLREKLTGLDKE--------KSLSDQR- 935
            ++                E  ++ QKL DD+  L+EK+    KE        +   +Q+ 
Sbjct: 872  NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931

Query: 936  ---RYSLIDPSSA----PELLRLQ--HQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKA 986
               R  + +P+ A    PE L  Q   Q  ST+ AL+    +A+Q+   +E +R+   ++
Sbjct: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991

Query: 987  QTIGNSGSANGIHQQDKAQKQED 1009
            Q         G  Q+++ Q++ +
Sbjct: 992  Q---------GQQQEERGQQERE 1005



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 127/623 (20%), Positives = 246/623 (39%), Gaps = 80/623 (12%)

Query: 435 LEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHS 494
           L+  + ++  L+ ++ +E   + +LEL     +  + + + ++ + +  I+ L       
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268

Query: 495 GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLR---DKYEKALKAYQAEVDKLRAANE 551
              P +  +  E+    E L     E  ++   L+    + ++ +     E   L     
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328

Query: 552 KYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLK-------------- 597
           ++A  +  L+D + + T E+      W  K   L  +   +L+D K              
Sbjct: 329 EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS 388

Query: 598 ------ATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGN---LQAKHD-LETAMHVKEK 647
                 + L   P  ++ E+      +E +K E      N   LQA+ + LET    +E 
Sbjct: 389 QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEA 448

Query: 648 EALREK--LQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVH------E 699
           + L E+   +E +++L+ L    ++ +    SQ + EL++A  Q   A L         E
Sbjct: 449 KLLAERGHFEEEKQQLSSLITDLQSSIS-NLSQAKEELEQA-SQAHGARLTAQVASLTSE 506

Query: 700 LEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQG-KQEVESLREKLLVAENR 758
           L  L+   + Q Q +  LK+Q    + ++    + Q   +QG + +VE L   L   E +
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566

Query: 759 LQAV-EALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQ 817
           L+ V E   +++  H  +    +EE   +    +    +L   +KE  A   + E+L+ Q
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA---KLEILQQQ 623

Query: 818 VSALESKCKSGEKKVDALLKEK-------RRLEAELETVSRKTHDASGQLVLI------- 863
           +        S +  V    +EK         L+A +ET  ++ H+A  Q+  +       
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683

Query: 864 SQELLRKER------SLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ-----KLK 912
            Q+   KER       L E    L E+ + + G    L  E  +A   ++EQ     +LK
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKG---SLEEEKRRAADALEEQQRCISELK 740

Query: 913 DDIRGLREKLTGLDKEKSLSDQR--------RYSLIDPSSAPELLRLQHQLMSTEDALRD 964
            + R L E+     + K L ++R        R   +  +   E   L+ +L     A   
Sbjct: 741 AETRSLVEQ--HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT 798

Query: 965 ALDQAQQVEKLMEAMRSCPDKAQ 987
           A  + +Q+ K + A R   + +Q
Sbjct: 799 AESECEQLVKEVAAWRERYEDSQ 821



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 115/537 (21%), Positives = 223/537 (41%), Gaps = 83/537 (15%)

Query: 349  RKISGTTALQEALKE-KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYV 407
            RK S  ++L+E +    +Q +E+    ++L+R  +A++     ++E+ + LL+A+     
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ-KLEERLRLLQAETASNS 1280

Query: 408  AEAEEKLQRARLLVESVRKE-------KVDLSNQLEEERRKVEDL---------QFRVEE 451
            A A E+    R  V+S+R+E         +L  +L  +  + E+L         +F  +E
Sbjct: 1281 ARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE 1340

Query: 452  ESITKGDLELT-TVAEKSRVL-------QLE-EELTLRRGEIEELQQCLLHSGPPPPDHP 502
            ++++   LE T T A  S +L       QL+ E+    +   EEL+Q    +G       
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGG------ 1394

Query: 503  DAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD 562
                   LR  LL A    QRE G L    +K  +  +    +LRA    YA++++ LK 
Sbjct: 1395 -------LRAELLRA----QRELGELIPLRQKVAEQ-ERTAQQLRAEKASYAEQLSMLKK 1442

Query: 563  KVQQATSENMGLMDN-------WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKE----- 610
                   EN GL +         + +LD     + + L  ++A   +     Q+E     
Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502

Query: 611  --IGELKAVMEGIKMEHQLELGNLQAKHDLETAM----------HVKEKEALREKLQEAQ 658
              +  + A  EG K++   E    Q +    TA             K+ E L +KL ++ 
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562

Query: 659  EELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAI---- 714
            +     Q+  +A ++ Q  + + E Q  Q Q  + + ++ + E+    Y+ Q +      
Sbjct: 1563 QASKVQQQKLKA-VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621

Query: 715  EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALC---SSQHT 771
            +  K+Q    ++++   E+LQ+   + + E E L  +L  A  + +  E  C   ++Q  
Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681

Query: 772  HMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 828
             +      +++ +R     +   D L  R+ +          L   + +L+  C+ G
Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSREPQA------KPQLDLSIDSLDLSCEEG 1732



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 50/253 (19%), Positives = 109/253 (43%), Gaps = 11/253 (4%)

Query: 324  SSVASSVGGRPSRSGLLTETSSRYARKIS-GTTALQEALKE-KQQHIEQLLAERDLERAE 381
            +S A  +       GLL E +     + + G   L+  L + +++++++L A R      
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR 1490

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
            +A+         +E+ ++ A++E    +  E+ QR        ++E+  L+ Q+E+    
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR-------FQEERQKLTAQVEQLEVF 1543

Query: 442  VEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 501
              +   +VEE S    D +  +  ++ ++  ++ +    + E + LQ  L          
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK 1603

Query: 502  PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEV--AG 559
              AAE  +L+        + +++      +  ++L+  Q E  +LRA  E+   E+  AG
Sbjct: 1604 EQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAG 1663

Query: 560  LKDKVQQATSENM 572
            LK K  + T  ++
Sbjct: 1664 LKTKEAEQTCRHL 1676


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  103 bits (257), Expect = 8e-22
 Identities = 152/697 (21%), Positives = 296/697 (42%), Gaps = 83/697 (11%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL 414
            T   + + EK Q  EQL AE +L  AE  +  + +   ++E+  +    E  V E EE+ 
Sbjct: 873  TLQSQLMAEKLQLQEQLQAETEL-CAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVEDLQF----------RVEEESITKGDLELTTV 464
            Q  +   + +++   +L  QLEEE    + LQ           ++EEE I   D      
Sbjct: 932  QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
             EK  +     E T    E EE  + L         +   A I  L ERL    K+ Q E
Sbjct: 992  KEKKLLEDRIAEFTTNLTEEEEKSKSLAKL-----KNKHEAMITDLEERLRREEKQRQ-E 1045

Query: 525  SGVLRDKYE-------KALKAYQAEVDKLRAANEKYAQEV-AGLKDKVQQATSENMGLMD 576
                R K E         +   QA++ +L+    K  +E+ A L    ++A  +NM L  
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105

Query: 577  NWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE----LK----------AVMEGIK 622
                +L+S  S+ Q+ LE  +A+ N     Q++++GE    LK          A  + ++
Sbjct: 1106 --IRELESQISELQEDLESERASRNKAE-KQKRDLGEELEALKTELEDTLDSTAAQQELR 1162

Query: 623  MEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELA-GLQRHWRAQLEVQASQHRL 681
             + + E+  L+   + E   H  + + +R+K  +A EELA  L++  R +  ++ ++  L
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222

Query: 682  E-------------LQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM 728
            E             LQ   D     +    +L++L V++    +    L ++++   K  
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT---KLQ 1279

Query: 729  LDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE 788
            ++ + +    +Q   +   L +     E++LQ  + L   ++   +    +S +  + ++
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL---SLSTKLKQVED 1336

Query: 789  TVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELET 848
                 +++L + ++    L  Q   L AQV+ ++ K +     ++   + KR+L+ +LE 
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396

Query: 849  VSRKTHDASGQLVLISQELLRKERSLNELRVLL-------------------LEANRHSP 889
            +S++  +       + +   R ++ L++L V L                   L A   + 
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456

Query: 890  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID-PSSAPEL 948
              +    R+  +AE R KE K     R L E +    + + L+ Q R  + D  SS  ++
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516

Query: 949  LRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD 984
             +  H+L  ++ AL   +++ + Q+E+L + +++  D
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553



 Score =  103 bits (256), Expect = 1e-21
 Identities = 146/681 (21%), Positives = 291/681 (42%), Gaps = 113/681 (16%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL 414
            T L+E L+ +++  ++L   R     +    +  I E++ +IA LK Q    +A+ EE+L
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ----LAKKEEEL 1085

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLE 474
            Q A   VE    +K     ++ E   ++ +LQ  +E E  ++        AEK +   L 
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK------AEKQK-RDLG 1138

Query: 475  EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEK 534
            EEL   + E+E+             D   A + LR          + ++E  +L+   E+
Sbjct: 1139 EELEALKTELEDTL-----------DSTAAQQELR---------SKREQEVNILKKTLEE 1178

Query: 535  ALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 594
              K ++A++ ++R   +K++Q V  L ++++Q       +  N +    +L ++  +   
Sbjct: 1179 EAKTHEAQIQEMR---QKHSQAVEELAEQLEQTKR----VKANLEKAKQTLENERGELAN 1231

Query: 595  DLKATLNSGPGAQQKEIGELKAVMEGIKMEH-----------------QLELGN---LQA 634
            ++K  L  G G  + +  +++A ++ ++++                  Q+EL N   L +
Sbjct: 1232 EVKVLL-QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290

Query: 635  KHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA------QLEVQASQHRLELQEAQD 688
            + D +++   K+  AL  +LQ+ QE L    R   +      Q+E + +  R +L+E ++
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350

Query: 689  QRRDAE-------LRVHELEKLDVEYRGQAQAIEFLKEQI--------SLAEKKMLDYER 733
             + + E        +V +++K   +  G  +  E +K ++           E+K+  Y++
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK 1410

Query: 734  LQRAEAQGKQEVESL-------REKLLVAENRLQAVEALCSSQHT---HMIESNDISEET 783
            L++ + + +QE++ L       R+     E + +  + L + + T      E  D +E  
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470

Query: 784  IRTKET-VEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRL 842
             R KET    L   L +  ++   L    +  R ++  L S      K V  L K KR L
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530

Query: 843  EAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKA 902
            E ++E +  +  +   +L       LR E +L  ++             ERDL     ++
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----------ERDLQGRDEQS 1580

Query: 903  EWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 962
                 E+K K  +R +RE       E  L D+R+   +  ++  +L      L +  D+ 
Sbjct: 1581 -----EEKKKQLVRQVRE------MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629

Query: 963  RDALDQA-QQVEKLMEAMRSC 982
                D+A +Q+ KL   M+ C
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDC 1650



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 137/677 (20%), Positives = 282/677 (41%), Gaps = 99/677 (14%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVA-KATSHICEVEKEIALLKAQHEQY------VAEA 410
            ++ ++ + Q ++    E +  R E+A K T    E++    LL     +        +  
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 411  EEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRV 470
            E +LQ  + L++   ++K+ LS +L++   +    + ++EEE   K +LE        ++
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-------KQI 1359

Query: 471  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRD 530
              L  ++   + ++E+   CL            A E+ R  ++ L    +   E     D
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCL----------ETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409

Query: 531  KYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ---QATSENMGLMDNWKSKLDSLAS 587
            K EK     Q E+D L    +   Q    L+ K +   Q  +E   +   +  + D   +
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469

Query: 588  DHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA-KHDLETAMHV-- 644
            + ++     K T         +E  E KA +E +  + + E+ +L + K D+  ++H   
Sbjct: 1470 EARE-----KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524

Query: 645  KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELE-KL 703
            K K AL ++++E + +L  L+                ELQ  +D +   E+ +  ++ + 
Sbjct: 1525 KSKRALEQQVEEMKTQLEELED---------------ELQATEDAKLRLEVNLQAMKAQF 1569

Query: 704  DVEYRGQAQAIEFLKEQISLAEKKM---LDYERLQRAEAQGKQEVESLREKLLVA----- 755
            + + +G+ +  E  K+Q+    ++M   L+ ER QR+ A   ++   +  K L A     
Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629

Query: 756  -ENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEML 814
             +NR +A++ L   Q     +  D   E   T+ + E +  +  + +K++ ++ ++   L
Sbjct: 1630 NKNRDEAIKQLRKLQ----AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685

Query: 815  RAQVSALESKCKSGEKKVDAL--------------LKEKRRLEAELETVSRKTHDASGQL 860
            + +++A E   +  +++ D L              L+EKRRLEA +  +  +  +  G  
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745

Query: 861  VLISQELLRKERSLNELRVLLLEANRHSPGPE---RDLSREVHKAEWRIKE------QKL 911
             LI+  L +    ++++   L     H+   E   + L R+  + + +++E       K 
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805

Query: 912  KDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQ 971
            K  I  L  K+  L+++     + R +               Q+  TE  L+D L Q   
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAAC------------KQVRRTEKKLKDVLLQVDD 1853

Query: 972  VEKLMEAMRSCPDKAQT 988
              +  E  +   DKA T
Sbjct: 1854 ERRNAEQYKDQADKAST 1870



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 125/574 (21%), Positives = 245/574 (42%), Gaps = 95/574 (16%)

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            S R+  K++    L++     QQ ++ LL + D +R    ++  ++ + +K+   L A+ 
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR----QSACNLEKKQKKFDQLLAEE 1453

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDL-----QFRVEEESI--TK 456
            +   A+  E+  RA         + + L+  LEE   +  +L     QFR E E +  +K
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513

Query: 457  GDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 516
             D+  +    +     LE+++   + ++EEL+           D   A E  +LR     
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELE-----------DELQATEDAKLR----- 1557

Query: 517  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMD 576
                            E  L+A +A+ ++     ++ ++E    K  V+Q       L D
Sbjct: 1558 ---------------LEVNLQAMKAQFERDLQGRDEQSEEKK--KQLVRQVREMEAELED 1600

Query: 577  NWKSKLDSLASDH--QKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
              K +  ++A+    +  L+DL+A ++S    + + I +L+ +   +K +   EL + +A
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK-DCMRELDDTRA 1659

Query: 635  KHDLETAMHVKEKE----ALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE----- 685
              + E     KE E    ++  ++ + QEELA  +R  R     QA Q R EL +     
Sbjct: 1660 SRE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR-----QAQQERDELADEIANS 1713

Query: 686  ------AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEA 739
                  A +++R  E R+ +LE+   E +G  + I    ++ +L   ++     L+R+ A
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773

Query: 740  Q----GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES-------------NDISEE 782
            Q     +Q++E   ++L V   +LQ +E    S++   I +             N+  E 
Sbjct: 1774 QKNENARQQLERQNKELKV---KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830

Query: 783  TIRTKE---TVEGLQDKLNKRDKE---VTALTSQTEMLRAQVSALESKCKSGEKKVDALL 836
                K+   T + L+D L + D E         Q +    ++  L+ + +  E++     
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRAN 1890

Query: 837  KEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
              +R+L+ ELE  + +T DA  + V   +  LR+
Sbjct: 1891 ASRRKLQRELEDAT-ETADAMNREVSSLKNKLRR 1923



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 119/548 (21%), Positives = 229/548 (41%), Gaps = 62/548 (11%)

Query: 416  RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRV---LQ 472
            + + L++  R+E+  ++   EEE  KV + Q   E        L+   +AEK ++   LQ
Sbjct: 833  KVKPLLQVSRQEEEMMAK--EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQ 890

Query: 473  LEEELTLRRGEI--------EELQQCLLHSGPPPPDHPDAAEILRLRERLLSAS----KE 520
             E EL     E+        +EL++          +  +  + L+  ++ +  +    +E
Sbjct: 891  AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950

Query: 521  HQRESGVLRDKY-------EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMG 573
               E    R K        E  LK  + E   L   N K A+E   L+D++ + T+ N+ 
Sbjct: 951  QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT-NLT 1009

Query: 574  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQ 633
              +     L  L + H+  + DL+  L      Q++E+ + +  +EG   +   ++  LQ
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRR-EEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068

Query: 634  AKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWR--AQLEVQASQHRLELQEAQDQRR 691
            A+         K++E L+  L   +EE A      +   +LE Q S+ + +L+  +  R 
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN 1128

Query: 692  DAELRV----HELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQ-EVE 746
             AE +      ELE L  E      +    +E  S  E+++   ++    EA+  + +++
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188

Query: 747  SLREKLLVAENRLQAVEALCSS-QHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 805
             +R+K        QAVE L    + T  +++N       + K+T+E  + +L    K + 
Sbjct: 1189 EMRQK------HSQAVEELAEQLEQTKRVKAN-----LEKAKQTLENERGELANEVKVLL 1237

Query: 806  ALTSQTEMLR----AQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLV 861
                 +E  R    AQ+  L+ K   GE+    L  +  +L+ EL+ V+     +  +  
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297

Query: 862  LISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREK 921
             ++++    E  L + + LL E NR              K     K ++++D+    RE+
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENR-------------QKLSLSTKLKQVEDEKNSFREQ 1344

Query: 922  LTGLDKEK 929
            L   ++ K
Sbjct: 1345 LEEEEEAK 1352



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 106/516 (20%), Positives = 214/516 (41%), Gaps = 76/516 (14%)

Query: 361  LKEKQQHIEQLLAE-----------RDLERAE----------VAKATSHICEVEKEIALL 399
            L++KQ+  +QLLAE           RD   AE          +A+A     E + E+  L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
              Q    + +           V  + K K  L  Q+EE + ++E+L+  ++     K  L
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
            E+   A K+   Q E +L  R  + EE ++ L+               +R  E  L   +
Sbjct: 1559 EVNLQAMKA---QFERDLQGRDEQSEEKKKQLVRQ-------------VREMEAELEDER 1602

Query: 520  EHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWK 579
            + +  +   R K E  LK  +A +D   +AN+   + +  L+ K+Q    + M  +D+ +
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHID---SANKNRDEAIKQLR-KLQAQMKDCMRELDDTR 1658

Query: 580  SKLDSL---ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKH 636
            +  + +   A +++K L+ ++A +       Q+E+   +      + E   EL +  A  
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQ----LQEELAAAERAKRQAQQERD-ELADEIANS 1713

Query: 637  DLETAMHVKEKEALREKLQEAQEELAGLQ--------RHWRAQLEVQASQHRLEL----- 683
              + A+ ++EK  L  ++ + +EEL   Q        R  +A L++      L L     
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773

Query: 684  -------QEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ 735
                   Q+ + Q ++ ++++ E+E  +  +Y+    A+E    Q+    ++ LD E  +
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL----EEQLDNETKE 1829

Query: 736  RAEA--QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL 793
            R  A  Q ++  + L++ LL  ++  +  E               +  +    +E  +  
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889

Query: 794  QDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 829
                 K  +E+   T   + +  +VS+L++K + G+
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 68/339 (20%), Positives = 150/339 (44%), Gaps = 36/339 (10%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L +   + +  ++    L+  LK+ + HI+     RD    ++ K  + + +  +E+   
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---EEERRKVEDLQFRVEEE---S 453
            +A  E+ +A+A+E  ++    ++S+  E + L  +L   E  +R+ +  +  + +E   S
Sbjct: 1658 RASREEILAQAKENEKK----LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1713

Query: 454  ITKGDLELTTVAE-KSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRE 512
              KG L L      ++R+ QLEEEL   +G  E +   L  +           +I ++  
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN---------LQIDQINT 1764

Query: 513  RLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLR-AANEKYAQEVAGLKDKVQQATSEN 571
              L+  + H +++   R + E+  K  + ++ ++      KY   +  L+ K+ Q   + 
Sbjct: 1765 D-LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ- 1822

Query: 572  MGLMDNWKSKLDSLASDHQKSLEDLKATL----NSGPGAQQKEIGELKAVMEGIKMEHQL 627
               +DN   +  +     +++ + LK  L    +    A+Q +    KA     +++ QL
Sbjct: 1823 ---LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879

Query: 628  ELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQR 666
            E    +A+ + + A   + K  L+ +L++A E    + R
Sbjct: 1880 E----EAEEEAQRANASRRK--LQRELEDATETADAMNR 1912



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 63/309 (20%), Positives = 126/309 (40%), Gaps = 35/309 (11%)

Query: 726  KKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIR 785
            K +L   R +      ++E+  +REK L AENRL  +E L S      ++  +  +    
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 786  TKETVEGLQDKLNKRDKEVTALTSQTEM-----------LRAQVSALESKCKSGEKKVDA 834
                 E L+ +L  + +E+  +    E            L+A+   ++   +  E++++ 
Sbjct: 895  LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 835  LLKEKRRLEAELETVSRKTHDASGQLVLISQE--LLRKERSLNELRVLLLEAN-RHSPGP 891
                +++L+ E  T   K      + +++  +   L KE+ L E R+     N       
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 892  ERDLSREVHKAEWRI--------KEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPS 943
             + L++  +K E  I        +E+K + ++   R KL G      LSDQ         
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--DSTDLSDQ------IAE 1066

Query: 944  SAPELLRLQHQLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIH 999
               ++  L+ QL   E+ L+ AL    ++A Q    ++ +R    +   +     +    
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA- 1125

Query: 1000 QQDKAQKQE 1008
             ++KA+KQ+
Sbjct: 1126 SRNKAEKQK 1134


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  103 bits (256), Expect = 1e-21
 Identities = 146/700 (20%), Positives = 286/700 (40%), Gaps = 90/700 (12%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEV---AKATSHICEVEKE 395
            L+E  +     IS  T  +++L+E  QQ ++ L  E D     +   AK      ++E  
Sbjct: 982  LSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS 1041

Query: 396  IAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE 452
            +     L+A  E+   + E  L+ ++  +  +  +K  +  +L+++  ++  LQ ++++E
Sbjct: 1042 LEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDE 1101

Query: 453  SITKGDLELTTVAEKSRVLQLEEEL----TLRRG----------EIEELQQCLLH----- 493
             +     +      ++R+ +LEEE+    TLR            E+EE+ + L       
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161

Query: 494  SGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 553
            S     +    AE  ++R  L  A+ +H+  +  LR K   ++     ++D L+   +K 
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKL 1221

Query: 554  AQEVAGLKDKVQQATSENMGLMDNWKSKLDSL------------ASDHQKS--LEDL--- 596
             +E + LK ++    S N+  +   KS ++              A D Q++  + DL   
Sbjct: 1222 EKEKSELKMEIDDMAS-NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280

Query: 597  KATLNSGPGAQQKEIGELKAVMEGI----------------KMEHQLELGNLQAKHDLET 640
            KA L +  G     + E ++++  +                +ME + +  N  A H L++
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA-HALQS 1339

Query: 641  AMHVKEKEALREKLQEAQEELAGLQR----------HWRAQLEVQASQHRLELQEAQDQR 690
            + H  + + LRE+ +E QE  A LQR           WR + E  A Q   EL+EA   +
Sbjct: 1340 SRH--DCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA---K 1394

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKMLDYERLQRAEAQGKQEVESLR 749
            +    R+ E E+       +  ++E  K+++    E  M D ER   A A   ++  +  
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFD 1454

Query: 750  EKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTS 809
            + L   + +L   +A   +      ES  +S E  + +   E + D+L    +E   L  
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511

Query: 810  QTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 869
            +   L  Q++      +  EK    + +EK  L+  LE V         +++ +  EL +
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ 1571

Query: 870  KERSLN--------ELRVLLLEANRHSPGPERDLSREVHKAEWRIK-EQKLKDDIRGLRE 920
             +  L+        E+  L   + R +   +  L  E+      ++ ++K++ D+  +  
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631

Query: 921  KLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTED 960
            +L G    +    Q+    +        L L   L S ED
Sbjct: 1632 QL-GHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 136/623 (21%), Positives = 263/623 (42%), Gaps = 82/623 (13%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI-ALLKAQH--EQYVAEAEEKLQRAR 418
            KE ++ +  LL E++  + +V   T ++ + E+    L+K++   E  V E  E+L+   
Sbjct: 875  KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEE 934

Query: 419  LLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEELT 478
             +   +  +K +L ++    +R ++DL+       +T   +E    A +++V  L EE+T
Sbjct: 935  EMNSELVAKKRNLEDKCSSLKRDIDDLE-------LTLTKVEKEKHATENKVKNLSEEMT 987

Query: 479  LRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKA 538
                 I +L +           H    + L++ E  ++   +   +     D  E +L+ 
Sbjct: 988  ALEENISKLTK---EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE- 1043

Query: 539  YQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKA 598
               +  KLRA  E+  +++ G     Q++  +    ++N K +++      +  L  L+A
Sbjct: 1044 ---QEKKLRADLERAKRKLEGDLKMSQESIMD----LENDKQQIEEKLKKKEFELSQLQA 1096

Query: 599  TLNSGPGAQ---QKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQ 655
             ++         QK+I EL+A +E ++ E       ++A+H L   +  K++  L  +L+
Sbjct: 1097 KIDDEQVHSLQFQKKIKELQARIEELEEE-------IEAEHTLRAKIE-KQRSDLARELE 1148

Query: 656  EAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYR-GQAQAI 714
            E  E L        AQ+E+   +      E Q  RRD E    + E      R  QA ++
Sbjct: 1149 EISERLEEASGATSAQIEMNKKRE----AEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204

Query: 715  EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMI 774
              L EQI          + LQR + + ++E   L+ ++   ++    +EAL  S+    I
Sbjct: 1205 AELGEQI----------DNLQRVKQKLEKEKSELKMEI---DDMASNIEALSKSKSN--I 1249

Query: 775  ESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEM----LRAQVSALESKCKSGEK 830
            E         RT  TVE    ++  +D++ T L     M    L+ Q   L  + +  E 
Sbjct: 1250 E---------RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300

Query: 831  KVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPG 890
             +  L K K+ L  +LE + R+  + +     ++  L       + LR    E       
Sbjct: 1301 LISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360

Query: 891  PERDLSR-EVHKAEWRIK--------EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             +R LS+     A+WR K         ++L++  + L ++L   ++    ++ +  SL  
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420

Query: 942  PSSAPELLRLQHQLMSTEDALRD 964
                    RLQ ++   ED +RD
Sbjct: 1421 TKQ-----RLQGEV---EDLMRD 1435



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 123/621 (19%), Positives = 265/621 (42%), Gaps = 78/621 (12%)

Query: 285  VIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETS 344
            ++R  +     AKA+  + ++   S +    +     ++         +   +  L E  
Sbjct: 1346 LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405

Query: 345  SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHE 404
                   S   +L++  +  Q  +E L+  RDLER+  A AT     ++K+    +   +
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLM--RDLERSHTACAT-----LDKK----QRNFD 1454

Query: 405  QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDL-----QFRVEEESITKGDL 459
            + +AE ++KL  ++  +E+ +KE   LS +L + R   E++       R E +++ +   
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEIS 1514

Query: 460  ELTT-VAEKSRVLQ--------LEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRL 510
            +LT  +AE  + LQ        +E+E +  +  +EE++  L H         + ++ILR+
Sbjct: 1515 DLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH---------EESKILRV 1565

Query: 511  RERLLSASKEHQR-------ESGVLRDKYEKALKAYQAEVD-KLRAANE--KYAQEVAGL 560
            +  L     E  R       E   L+   ++A +A Q+ +D ++R+ N+  +  +++ G 
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625

Query: 561  KDKVQQATSENMGLMDNWKSKLDSLAS----------DHQKSLEDLK---ATLNSGPGAQ 607
             ++++     +   M   +  L ++            D  +S EDLK   A +    G  
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685

Query: 608  QKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH 667
             +E+ E+K  +E  +   +L    L    D    +H +    +  K ++ + ++A  Q  
Sbjct: 1686 LEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTK-KKLEADIAQCQ-- 1742

Query: 668  WRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKK 727
              A++E    + R   ++A+    DA +   EL+K     +  +  +E +K+ +    K 
Sbjct: 1743 --AEVENSIQESRNAEEKAKKAITDAAMMAEELKK----EQDTSAHLERMKKNLEQTVKD 1796

Query: 728  MLDYERLQRAEAQ----GKQEVESLREKLLVAENRL-----QAVEALCSSQHTHMIESND 778
            +    RL  AE      GK++++ L  ++   EN L     +  EAL    H +  +  +
Sbjct: 1797 L--QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL-KGAHKYERKVKE 1853

Query: 779  ISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKE 838
            ++ +     + +  LQD ++K   +V +   Q E    Q +   S+C+  + +++   + 
Sbjct: 1854 MTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAER 1913

Query: 839  KRRLEAELETVSRKTHDASGQ 859
                E+++  +  K+ D   Q
Sbjct: 1914 ADIAESQVNKLRAKSRDVGSQ 1934



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 111/496 (22%), Positives = 209/496 (42%), Gaps = 74/496 (14%)

Query: 515  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 574
            L  S E ++E   +++ +E+  +       + +   EK    +    D   Q  SE   L
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902

Query: 575  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQA 634
            MD         A +  + L   K  L     A+ KE+ E     E +  E   +  NL+ 
Sbjct: 903  MD---------AEERCEGLIKSKILLE----AKVKELTERLEEEEEMNSELVAKKRNLED 949

Query: 635  K--------HDLETAMHV--KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 684
            K         DLE  +    KEK A   K++   EE+  L+ +       + ++ +  LQ
Sbjct: 950  KCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENIS-----KLTKEKKSLQ 1004

Query: 685  EAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ 740
            EA  Q  D     E +V+ L K++ +   Q   +E   EQ    EKK+     L+RA+ +
Sbjct: 1005 EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQ----EKKLR--ADLERAKRK 1058

Query: 741  GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TVEGLQDKLNK 799
             + +++  +E ++  EN  Q +E                  E ++ KE  +  LQ K++ 
Sbjct: 1059 LEGDLKMSQESIMDLENDKQQIE------------------EKLKKKEFELSQLQAKID- 1099

Query: 800  RDKEVTALTSQTEM--LRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDAS 857
             D++V +L  Q ++  L+A++  LE + ++       + K++  L  ELE +S +  +AS
Sbjct: 1100 -DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS 1158

Query: 858  GQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRG 917
            G      +   ++E    ++R  L EA          L ++   +   + EQ   D+++ 
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ--IDNLQR 1216

Query: 918  LREKLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQV 972
            +++K   L+KEKS   + +  + D +S  E L      ++    + ED   +   + +Q 
Sbjct: 1217 VKQK---LEKEKS---ELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270

Query: 973  EKLMEAMRSCPDKAQT 988
             +L+  +     + QT
Sbjct: 1271 TQLIHDLNMQKARLQT 1286


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score =  102 bits (255), Expect = 1e-21
 Identities = 135/593 (22%), Positives = 250/593 (42%), Gaps = 95/593 (16%)

Query: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260
           SGS +S   S +     LR+G RV ++G    G V YVG T FA G+W GV LDE  GKN
Sbjct: 14  SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69

Query: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP----------------------- 295
           DG V G +YF C    G+F      +V   G  +TSP                       
Sbjct: 70  DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129

Query: 296 ------------------AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRS 337
                              + K T+  + GV+  + S   S  +S   ++SS    P+++
Sbjct: 130 KLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQT 189

Query: 338 GLLTE-------TSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHIC 390
            L          TS      +   +  +E L+ + + +E+ L    L+RAE     + + 
Sbjct: 190 PLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE---DKAKLK 246

Query: 391 EVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK----VEDLQ 446
           E+EK     K Q EQ V E + K+Q          +++ DL  +L+E R++    +E  +
Sbjct: 247 ELEKH----KIQLEQ-VQEWKSKMQ----------EQQADLQRRLKEARKEAKEALEAKE 291

Query: 447 FRVEEESITKGDLELTTVAE---KSRVLQLEEELTLRRGEIEELQQCL--LHSGPPPPDH 501
             +EE + T   +E+ T+ +   + R   L++E+   +  ++EL   L  L +       
Sbjct: 292 RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS 351

Query: 502 PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLK 561
             AA   +L++  L       +++ V       + K    ++ KL     +  + V   +
Sbjct: 352 DGAASSYQLKQ--LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 409

Query: 562 DKVQQATSENMGLMDNWKSKLDSL--ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME 619
           +++Q+  S+    +D  K ++D+   A +  + L D    L       ++ +G+L+A+ E
Sbjct: 410 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNE 469

Query: 620 -GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 678
              +++       L+ +  L+ A   + +EA +++++ AQE +A  Q+  +   ++ A  
Sbjct: 470 MNDELQENARETELELREQLDMA-GARVREA-QKRVEAAQETVADYQQTIKKYRQLTAHL 527

Query: 679 HRLELQEAQDQRRDAELR------VHELEKLDVEYRGQAQAIEFLKEQISLAE 725
             +  +    Q    E +        + +    E +  A+AIE    Q+ +A+
Sbjct: 528 QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 580



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 131/577 (22%), Positives = 228/577 (39%), Gaps = 91/577 (15%)

Query: 42  SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100
           S  H  S  PS S  +A A  +P                VG RV V G    G V Y+G 
Sbjct: 4   SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49

Query: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160
           T FA G+W GV+LD+  GKNDG V G +YF C    GIF R S++  Q   +G+ + +  
Sbjct: 50  TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107

Query: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNE--------------SGSNL 206
               +A  +    GT T   TS++  L+     ++ KT                 + S+L
Sbjct: 108 TPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSL 167

Query: 207 SDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAG 266
             SGS   GE    L         +T +   +  T           L  P  + +G  A 
Sbjct: 168 GPSGSASAGE----LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQ 223

Query: 267 TRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSV 326
            R  +            + +R+   +   AK K+ ++  + +  +    S          
Sbjct: 224 VRDLE---------EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273

Query: 327 ASSVGGRPSRSGLLTETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVA 383
                 R      L E   RY  +++ T  A++ A  +K+      +AE   E  + EV 
Sbjct: 274 RRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVE 326

Query: 384 KATSHICEVEKEIALLKA-----------------QHEQYVAEAEEKLQRARLLVESVRK 426
                + E+  ++ +LKA                 Q E+  A  ++ L R R L  S ++
Sbjct: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386

Query: 427 EKVDLSNQLEEERRKVEDLQFRVE--EESITKGDLELTTVAEKSRVL----QLEEELTLR 480
           E V L   +E++ +++E ++ + E  +E +++ +  +  + E+        ++ E LT R
Sbjct: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 446

Query: 481 RGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE-------SGVLRDKYE 533
              +EE  + L  +        D   +  + + L   ++E + E       +G    + +
Sbjct: 447 NLNLEEKVRELRET------VGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQ 500

Query: 534 KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSE 570
           K ++A Q  V   +   +KY Q  A L+D  ++ T++
Sbjct: 501 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 537



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%)

Query: 715 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 773
           E L+ Q+   E+K L+  RL+RAE + K +E+E  + +L   +     ++   +     +
Sbjct: 218 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276

Query: 774 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 833
            E+   ++E +  KE      +++      +   T   EM   +  +L+ + ++ +++VD
Sbjct: 277 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333

Query: 834 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 880
            L  +   L+AE+E        +S QL  + ++  R + +L  +R L             
Sbjct: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393

Query: 881 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 932
           L+E         R     L  E+ +AE  I E K + D     E++  +  +++L+    
Sbjct: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453

Query: 933 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 985
             + R ++ D  +  E+   LQ     TE  LR+ LD A    ++ +K +E A  +  D 
Sbjct: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513

Query: 986 AQTI 989
            QTI
Sbjct: 514 QQTI 517


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score =  101 bits (251), Expect = 4e-21
 Identities = 139/639 (21%), Positives = 292/639 (45%), Gaps = 66/639 (10%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHIC-EVEKEIALLKAQHEQYVAEAEEKL 414
            A++EA+ +  +  ++ L E   E+ +  +    +C E E+EI  L  Q EQ ++   E+L
Sbjct: 594  AMEEAVAQVLEQDQRHLLESKQEKMQQLR--EKLCQEEEEEILRLHQQKEQSLSSLRERL 651

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLE 474
            Q+A      + +E+   +   EEE +++  L  R + +S T+ D +     +++ + +L 
Sbjct: 652  QKA------IEEEE---ARMREEESQRLSWL--RAQVQSSTQADEDQIRAEQEASLQKLR 700

Query: 475  EEL-TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE------HQRESGV 527
            EEL + ++ E   L+Q          +  +A+E  +  +  L+A+KE       ++  G 
Sbjct: 701  EELESQQKAERASLEQKNRQMLEQLKEEIEASE--KSEQAALNAAKEKALQQLREQLEGE 758

Query: 528  LRDKYEKALKAYQAEVDKLRAANE-KYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLA 586
             ++      K + AE+++L ++ E K+ + V+ L+ K+Q+A  +    +     +++   
Sbjct: 759  RKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRV 818

Query: 587  SDHQKS--LEDLKATLNSGPGAQQKEI-GELKAVMEGIKMEHQLELGNLQAKHDLETAMH 643
              HQKS  +   +  L+S    +++E+ GE +  ++ +K EHQ  +   + +++ E    
Sbjct: 819  --HQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE---- 872

Query: 644  VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 703
              E++   E L     EL  LQR    +LE    +    L++ + + R+ E ++ +LE L
Sbjct: 873  --ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE-L 929

Query: 704  DVEYRGQ--AQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQA 761
            D+E R +     +  L+ Q   A ++      +QR  A   +E  +  ++L  A+     
Sbjct: 930  DLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQ----- 984

Query: 762  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 821
                   +HTH+++SN       + +E ++ LQ +  K + +V  L +Q++ L+   S+L
Sbjct: 985  ------KEHTHLLQSNQ------QLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSL 1032

Query: 822  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 881
            E++ +  +  +  +  E+       E      H    +  L + +      SL++ +  L
Sbjct: 1033 EAEAQKKQHLLREVTVEENNASPHFEP---DLHIEDLRKSLGTNQTKEVSSSLSQSKEDL 1089

Query: 882  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
               +  S      LS E      R  ++ L    R +R + T L   K+     R+ L  
Sbjct: 1090 YLDSLSSHNVWHLLSAE--GVALRSAKEFLVQQTRSMRRRQTAL---KAAQQHWRHEL-- 1142

Query: 942  PSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMR 980
             +SA E+ +    + + ED  ++   + + ++++  AMR
Sbjct: 1143 -ASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMR 1180



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 127/547 (23%), Positives = 226/547 (41%), Gaps = 101/547 (18%)

Query: 356  ALQEALKEK--QQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEK 413
            A   A KEK  QQ  EQL  ER    A + K   H  E+E+  + L+A+H + V+  ++K
Sbjct: 738  AALNAAKEKALQQLREQLEGERKEAVATLEK--EHSAELERLCSSLEAKHREVVSSLQKK 795

Query: 414  LQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQL 473
            +Q A+      +KE+  L   L +   +V    + V         L    + EK + ++ 
Sbjct: 796  IQEAQ------QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL----LREKRQEVEG 845

Query: 474  EEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 533
            E E  L + + EE QQ +            A E     ER     K+     G L  + E
Sbjct: 846  EHERRLDKMK-EEHQQVM----------AKAREQYEAEER-----KQRAELLGHLTGELE 889

Query: 534  KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSL 593
            +  +A++ E++ +R    K  +++     + ++              KL  L  D +   
Sbjct: 890  RLQRAHERELETVRQEQHKRLEDLRRRHREQER--------------KLQDLELDLETRA 935

Query: 594  EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREK 653
            +D+KA L             L  V E      + +L ++Q     + A+  +E  A  ++
Sbjct: 936  KDVKARL------------ALLEVQEETARREKQQLLDVQR----QVALKSEEATATHQQ 979

Query: 654  LQEAQEE----LAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRG 709
            L+EAQ+E    L   Q+      E+QA + +LE Q    Q +  +L+ H    L+ E   
Sbjct: 980  LEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKH-FSSLEAE--- 1035

Query: 710  QAQAIEFLKEQISLAEKKM-------LDYERLQRAEAQGKQEVESLREKLLVAENRLQAV 762
             AQ  + L  ++++ E          L  E L++  + G  + + +   L  ++  L  +
Sbjct: 1036 -AQKKQHLLREVTVEENNASPHFEPDLHIEDLRK--SLGTNQTKEVSSSLSQSKEDLY-L 1091

Query: 763  EALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALE 822
            ++L S    H+     +S E +  +   E L  +     +  TAL +  +  R ++++ +
Sbjct: 1092 DSLSSHNVWHL-----LSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQ 1146

Query: 823  SKCKS--GEKKVD----ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNE 876
               K   G K ++     L KE R L+ E+++  RK H+           L +KE  LN+
Sbjct: 1147 EVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHNL----------LKKKEEKLNQ 1195

Query: 877  LRVLLLE 883
            L   L E
Sbjct: 1196 LESSLWE 1202



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 103/490 (21%), Positives = 199/490 (40%), Gaps = 76/490 (15%)

Query: 559  GLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL--KATLNSGPGAQQKEIGELKA 616
            GL +K +   SE     +    K D   S+  K+ E    + T+++G    ++E    +A
Sbjct: 309  GLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRRE----EA 364

Query: 617  VMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQA 676
              E  K    LE G+  A  +LE + H+KE + L + +    +   GL   +R+++    
Sbjct: 365  AKEPKKKASALEEGSSDASQELEISEHMKEPQ-LSDSIASDPKSFHGLDFGFRSRI---- 419

Query: 677  SQHRLEL-----------QEAQ-----DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQ 720
            S+H L++           ++AQ     + + D++    EL+    +   +  +     E+
Sbjct: 420  SEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEE 479

Query: 721  ISLAEKKMLDYE-----------RLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQ 769
             + +  + L  E             + AE  G+    SL  +L +   +  +  A C   
Sbjct: 480  RAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKG 539

Query: 770  HTHMIESNDISEETIRTKETVEGLQDKLN-KRDKEVTALTSQTEMLRAQVSALESKCKSG 828
                 E +  +EE    +E  E  ++K+       V+     TE +       E+  K+ 
Sbjct: 540  K----EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAM 595

Query: 829  EKKVDALLKEKRR--LEAELETVSRKTHDASGQLVLISQELLR----KERSLNELRVLLL 882
            E+ V  +L++ +R  LE++ E + +       +     +E+LR    KE+SL+ LR    
Sbjct: 596  EEAVAQVLEQDQRHLLESKQEKMQQLREKLCQE---EEEEILRLHQQKEQSLSSLR---- 648

Query: 883  EANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDP 942
                     ER L + + + E R++E++         ++L+ L  +   S Q     I  
Sbjct: 649  ---------ER-LQKAIEEEEARMREEE--------SQRLSWLRAQVQSSTQADEDQIRA 690

Query: 943  SSAPELLRLQHQLMSTEDALRDALDQ--AQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQ 1000
                 L +L+ +L S + A R +L+Q   Q +E+L E + +     Q   N+     + Q
Sbjct: 691  EQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750

Query: 1001 QDKAQKQEDK 1010
              +  + E K
Sbjct: 751  LREQLEGERK 760


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  100 bits (249), Expect = 7e-21
 Identities = 152/678 (22%), Positives = 288/678 (42%), Gaps = 97/678 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LT  +S+Y + IS T    E   E+++  EQ  AE     AEV  A     ++ +  A  
Sbjct: 1326 LTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
            KAQ E+   E ++++Q      E VR+E+  +  Q ++   + E  Q R   E+  +   
Sbjct: 1383 KAQAEREAKELQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
                 AE+SR L++EEE+ + R ++E  ++     G    +     + LR R     A K
Sbjct: 1438 RQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGGAEGE----LQALRARAEEAEAQK 1489

Query: 520  EHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDN 577
               +E    + R   +++ +  QAEV+   A+  K   E A  K +  QA  E       
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAEAEAAREKQRALQALEE------- 1540

Query: 578  WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHD 637
                L   A + ++ L             +Q E+   + V   ++   +     LQ+K  
Sbjct: 1541 ----LRLQAEEAERRL-------------RQAEVERARQVQVALETAQRSAEAELQSKR- 1582

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRV 697
               A   ++   L   LQE    +A L+     + + QA   R   +EA+ +    +L+ 
Sbjct: 1583 ---ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKA 1638

Query: 698  HELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLV--- 754
            +E  +L ++    AQ     ++ ++ AE +    E  + A  +GK E +++R++ L    
Sbjct: 1639 NEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 755  AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEML 814
             E + Q  E     +     E   +  ET + ++  + L+++L +  +E  A T + + L
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 815  RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD----ASGQLVLISQELLRK 870
             A+++ + +       +++ LL  K R E E  + S K+       +G+   +++E  R 
Sbjct: 1754 EAELAKVRA-------EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR- 1805

Query: 871  ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ--------KLKDDIR-GLREK 921
                  LR L  EA R     E D +R+  +AE  + E+        +LK +    L+EK
Sbjct: 1806 ------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 922  LTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLMSTEDA-----------LRDALDQ 968
                ++ + L++   +    ++  +A     ++ +L     A           + D L Q
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 969  AQQVEKLMEAMRSCPDKA 986
             +QVE+ + A+++  +KA
Sbjct: 1920 RRQVEEEILALKASFEKA 1937



 Score =  100 bits (248), Expect = 9e-21
 Identities = 137/610 (22%), Positives = 258/610 (42%), Gaps = 83/610 (13%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQ---YVAEAEEK 413
            LQ+ L+++Q  ++QL  E +  R    +A     + E+E A  + Q E+       AEE+
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124

Query: 414  LQ---RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLEL------TTV 464
             Q   +A+   E +RKE        +E  R+ +  Q  + ++     ++E        T+
Sbjct: 2125 AQARAQAQAAAEKLRKEAE------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
             +K+   Q+E+ELT  R ++EE             DH        L +  L   K    E
Sbjct: 2179 RQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQRLKAEATE 2218

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATSENMGLMDN 577
            +   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +E M  +  
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 578  WKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVMEGIKMEHQL 627
              ++L   A +     Q + EDL         AQQ+ + E      ++AV E  +++ + 
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQEATRLKAEA 2329

Query: 628  ELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQASQHRLEL 683
            EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ A   RL+L
Sbjct: 2330 EL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 684  QEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERLQRAEAQGK 742
            + A+  R  A       E+    +R QA+ I     +  LA ++K+   + L+    Q  
Sbjct: 2388 RVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 743  QEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKETVEGLQDKL 797
             + E LRE +   E   + ++         S+    ++   + +ET   +++    +D L
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 798  NKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA 856
             +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E   R+ H+A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 857  SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIR 916
               +    +EL + E+   +   LL E N+     +  L  E H+A     E+     + 
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 917  GLREKLTGLD 926
              +    G D
Sbjct: 2622 ATKTLPNGRD 2631



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 171/777 (22%), Positives = 309/777 (39%), Gaps = 141/777 (18%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1799 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 446  -QFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDA 504
             Q R  EE I    L L    EK+   + E EL L  G I    +  L S        + 
Sbjct: 1918 RQRRQVEEEI----LALKASFEKAAAGKAELELEL--GRIRSNAEDTLRS-------KEQ 1964

Query: 505  AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY------AQEVA 558
            AE+   R+R L+A +E +R      ++ +K+L A +    + +AA E+        +E  
Sbjct: 1965 AELEAARQRQLAAEEERRRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 559  GLKDKVQQATSENMGLMDNWKSK-------------------LDSLASDHQKSLEDLKAT 599
             L+++ +Q ++  + L      K                   L       Q  L+ L+  
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 600  LNSGP-GAQQKEIGELKAVMEGIKMEHQLELGN---------LQAKHDLETAMHVKEKEA 649
              +    A++ E   ++A  E  +   Q+E             QA+   + A     KEA
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 650  LREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEAQDQR 690
             +E  + AQ E A L++                     +AQ+E + +  RL+L+E   Q+
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK------- 742
                L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +       
Sbjct: 2203 N---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 743  --------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT----KETV 790
                    +E E +++   VAE   +   A   +     +   D++++        KE +
Sbjct: 2260 DNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 791  EGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAELETV 849
            + +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE +  
Sbjct: 2317 QAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 850  SRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW----- 904
               + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E      
Sbjct: 2376 LEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELATQEK 2427

Query: 905  -------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
                    I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q QL+ 
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QEQLLQ 2486

Query: 958  TEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1010
               AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQQ 2540



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 153/693 (22%), Positives = 288/693 (41%), Gaps = 102/693 (14%)

Query: 357  LQEALKEKQQHIEQLLA-------------ERDLERAEVAKATSHICEVEKEIALLKAQH 403
            +++ L++++Q  E++LA             E +LE   +          +++  L  A+ 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
             Q  AE E + + A   V+     + + + Q +    +VE L+ +VEE    +   E   
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE--- 2029

Query: 464  VAEKSRVLQLEEELTLRRGEIE-------------ELQQCLLHSGPPPPDHPDAAEIL-R 509
              E +R LQL +E   +R + E             ELQQ L             AE   R
Sbjct: 2030 -QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 510  LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANE---------KYAQEVAGL 560
              E    A  + +RE+   R + E+A +  Q+  ++ +A  +         K A++ A  
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 561  KDKVQQATSENMGLMDNWKSKLDSLA-----------------------SDHQKSLED-- 595
            + + +QA        D    K    A                       +DHQK+L D  
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 596  ---LKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLET-AMHVKEKEALR 651
               LKA   +   A+Q+   E +     ++ME   EL  L+A+ + E  A+ +++K+  +
Sbjct: 2209 LQRLKA--EATEAARQRSQVEEELFSVRVQME---ELSKLKARIEAENRALILRDKDNTQ 2263

Query: 652  EKLQEAQEELAGLQRHWRAQLEVQASQ----HRLELQEAQDQRRDAELRVHE-LEKLDVE 706
              LQE  E++  +     A+L V A +     +L  ++   QR  AE  + E ++ +   
Sbjct: 2264 RFLQEEAEKMKQVAEE-AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 707  YRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALC 766
             R +A+A E L++Q  LA+++    +  +   AQ   E     ++ L AE + Q    + 
Sbjct: 2323 TRLKAEA-ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL--EMS 2379

Query: 767  SSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCK 826
            +      +   ++S    R +E  +    +  K+ +E+     +TE+   +   L    +
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435

Query: 827  SGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQEL--LRKERSLNELRVLLLEA 884
               ++ D   +  R   AELE    K    +  L L S+E+  +++E+ L E + L    
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL---- 2491

Query: 885  NRHSPGPERD--LSREVHKAEWRIK-EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             + S   E+D  L RE    + + K EQ  +D++   ++      +++   +Q R  L+ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 942  PSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
             +S  E  R QH+    E+ +R   ++ QQ+E+
Sbjct: 2550 -ASMEEARRRQHE---AEEGVRRKQEELQQLEQ 2578



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 163/703 (23%), Positives = 287/703 (40%), Gaps = 155/703 (22%)

Query: 369  EQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVES----- 423
            ++L+AER     E    + H  ++ + +    AQ E        +L+  RL +E+     
Sbjct: 950  DRLMAER-----EYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELKDIRLQLEACETRT 1003

Query: 424  VRKEKVDLSNQLEEE--RRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQ--------L 473
            V + ++ L  +   E  +R  E  + + E E + KG   L+  AEK   L         L
Sbjct: 1004 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1063

Query: 474  EEELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEH 521
              EL L  G++E+++              L+  G        A E+LR  E  L   KE 
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEA 1115

Query: 522  QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSEN 571
            Q     L +     L+A +A + KLRA  E        L+D          ++QQ   E 
Sbjct: 1116 QAVPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170

Query: 572  MGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE--- 628
               ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E   
Sbjct: 1171 DVEVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESAD 1217

Query: 629  -----LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH---------------- 667
                 L + + + +   AM + + +A+RE+L++ Q  L  ++RH                
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277

Query: 668  -----------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQA 711
                       ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y    
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY---- 1333

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHT 771
              I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++  
Sbjct: 1334 --IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 772  HMIESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKS 827
               E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEA 1442

Query: 828  GEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH 887
             E+    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER- 1498

Query: 888  SPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE 947
                   L R+V     R ++ +++   R   E     +K+++L             A E
Sbjct: 1499 -------LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALE 1539

Query: 948  LLRLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 988
             LRLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1540 ELRLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  100 bits (249), Expect = 7e-21
 Identities = 152/678 (22%), Positives = 288/678 (42%), Gaps = 97/678 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LT  +S+Y + IS T    E   E+++  EQ  AE     AEV  A     ++ +  A  
Sbjct: 1330 LTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1386

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
            KAQ E+   E ++++Q      E VR+E+  +  Q ++   + E  Q R   E+  +   
Sbjct: 1387 KAQAEREAKELQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1441

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
                 AE+SR L++EEE+ + R ++E  ++     G    +     + LR R     A K
Sbjct: 1442 RQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGGAEGE----LQALRARAEEAEAQK 1493

Query: 520  EHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDN 577
               +E    + R   +++ +  QAEV+   A+  K   E A  K +  QA  E       
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAEAEAAREKQRALQALEE------- 1544

Query: 578  WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHD 637
                L   A + ++ L             +Q E+   + V   ++   +     LQ+K  
Sbjct: 1545 ----LRLQAEEAERRL-------------RQAEVERARQVQVALETAQRSAEAELQSKR- 1586

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRV 697
               A   ++   L   LQE    +A L+     + + QA   R   +EA+ +    +L+ 
Sbjct: 1587 ---ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKA 1642

Query: 698  HELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLV--- 754
            +E  +L ++    AQ     ++ ++ AE +    E  + A  +GK E +++R++ L    
Sbjct: 1643 NEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 755  AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEML 814
             E + Q  E     +     E   +  ET + ++  + L+++L +  +E  A T + + L
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757

Query: 815  RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD----ASGQLVLISQELLRK 870
             A+++ + +       +++ LL  K R E E  + S K+       +G+   +++E  R 
Sbjct: 1758 EAELAKVRA-------EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR- 1809

Query: 871  ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ--------KLKDDIR-GLREK 921
                  LR L  EA R     E D +R+  +AE  + E+        +LK +    L+EK
Sbjct: 1810 ------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863

Query: 922  LTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLMSTEDA-----------LRDALDQ 968
                ++ + L++   +    ++  +A     ++ +L     A           + D L Q
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923

Query: 969  AQQVEKLMEAMRSCPDKA 986
             +QVE+ + A+++  +KA
Sbjct: 1924 RRQVEEEILALKASFEKA 1941



 Score =  100 bits (248), Expect = 9e-21
 Identities = 137/610 (22%), Positives = 258/610 (42%), Gaps = 83/610 (13%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQ---YVAEAEEK 413
            LQ+ L+++Q  ++QL  E +  R    +A     + E+E A  + Q E+       AEE+
Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128

Query: 414  LQ---RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLEL------TTV 464
             Q   +A+   E +RKE        +E  R+ +  Q  + ++     ++E        T+
Sbjct: 2129 AQARAQAQAAAEKLRKEAE------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
             +K+   Q+E+ELT  R ++EE             DH        L +  L   K    E
Sbjct: 2183 RQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQRLKAEATE 2222

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATSENMGLMDN 577
            +   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +E M  +  
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282

Query: 578  WKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVMEGIKMEHQL 627
              ++L   A +     Q + EDL         AQQ+ + E      ++AV E  +++ + 
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQEATRLKAEA 2333

Query: 628  ELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQASQHRLEL 683
            EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ A   RL+L
Sbjct: 2334 EL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2391

Query: 684  QEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERLQRAEAQGK 742
            + A+  R  A       E+    +R QA+ I     +  LA ++K+   + L+    Q  
Sbjct: 2392 RVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446

Query: 743  QEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKETVEGLQDKL 797
             + E LRE +   E   + ++         S+    ++   + +ET   +++    +D L
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506

Query: 798  NKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA 856
             +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E   R+ H+A
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566

Query: 857  SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIR 916
               +    +EL + E+   +   LL E N+     +  L  E H+A     E+     + 
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSEEVTASQVA 2625

Query: 917  GLREKLTGLD 926
              +    G D
Sbjct: 2626 ATKTLPNGRD 2635



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 171/777 (22%), Positives = 309/777 (39%), Gaps = 141/777 (18%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1803 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921

Query: 446  -QFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDA 504
             Q R  EE I    L L    EK+   + E EL L  G I    +  L S        + 
Sbjct: 1922 RQRRQVEEEI----LALKASFEKAAAGKAELELEL--GRIRSNAEDTLRS-------KEQ 1968

Query: 505  AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY------AQEVA 558
            AE+   R+R L+A +E +R      ++ +K+L A +    + +AA E+        +E  
Sbjct: 1969 AELEAARQRQLAAEEERRRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026

Query: 559  GLKDKVQQATSENMGLMDNWKSK-------------------LDSLASDHQKSLEDLKAT 599
             L+++ +Q ++  + L      K                   L       Q  L+ L+  
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086

Query: 600  LNSGP-GAQQKEIGELKAVMEGIKMEHQLELGN---------LQAKHDLETAMHVKEKEA 649
              +    A++ E   ++A  E  +   Q+E             QA+   + A     KEA
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146

Query: 650  LREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEAQDQR 690
             +E  + AQ E A L++                     +AQ+E + +  RL+L+E   Q+
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK------- 742
                L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +       
Sbjct: 2207 N---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263

Query: 743  --------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT----KETV 790
                    +E E +++   VAE   +   A   +     +   D++++        KE +
Sbjct: 2264 DNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 791  EGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAELETV 849
            + +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE +  
Sbjct: 2321 QAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379

Query: 850  SRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW----- 904
               + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E      
Sbjct: 2380 LEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELATQEK 2431

Query: 905  -------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
                    I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q QL+ 
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QEQLLQ 2490

Query: 958  TEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1010
               AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ +
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQQ 2544



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 153/693 (22%), Positives = 288/693 (41%), Gaps = 102/693 (14%)

Query: 357  LQEALKEKQQHIEQLLA-------------ERDLERAEVAKATSHICEVEKEIALLKAQH 403
            +++ L++++Q  E++LA             E +LE   +          +++  L  A+ 
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
             Q  AE E + + A   V+     + + + Q +    +VE L+ +VEE    +   E   
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE--- 2033

Query: 464  VAEKSRVLQLEEELTLRRGEIE-------------ELQQCLLHSGPPPPDHPDAAEIL-R 509
              E +R LQL +E   +R + E             ELQQ L             AE   R
Sbjct: 2034 -QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 510  LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANE---------KYAQEVAGL 560
              E    A  + +RE+   R + E+A +  Q+  ++ +A  +         K A++ A  
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152

Query: 561  KDKVQQATSENMGLMDNWKSKLDSLA-----------------------SDHQKSLED-- 595
            + + +QA        D    K    A                       +DHQK+L D  
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212

Query: 596  ---LKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLET-AMHVKEKEALR 651
               LKA   +   A+Q+   E +     ++ME   EL  L+A+ + E  A+ +++K+  +
Sbjct: 2213 LQRLKA--EATEAARQRSQVEEELFSVRVQME---ELSKLKARIEAENRALILRDKDNTQ 2267

Query: 652  EKLQEAQEELAGLQRHWRAQLEVQASQ----HRLELQEAQDQRRDAELRVHE-LEKLDVE 706
              LQE  E++  +     A+L V A +     +L  ++   QR  AE  + E ++ +   
Sbjct: 2268 RFLQEEAEKMKQVAEE-AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326

Query: 707  YRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALC 766
             R +A+A E L++Q  LA+++    +  +   AQ   E     ++ L AE + Q    + 
Sbjct: 2327 TRLKAEA-ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL--EMS 2383

Query: 767  SSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCK 826
            +      +   ++S    R +E  +    +  K+ +E+     +TE+   +   L    +
Sbjct: 2384 AEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439

Query: 827  SGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQEL--LRKERSLNELRVLLLEA 884
               ++ D   +  R   AELE    K    +  L L S+E+  +++E+ L E + L    
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL---- 2495

Query: 885  NRHSPGPERD--LSREVHKAEWRIK-EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             + S   E+D  L RE    + + K EQ  +D++   ++      +++   +Q R  L+ 
Sbjct: 2496 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2553

Query: 942  PSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
             +S  E  R QH+    E+ +R   ++ QQ+E+
Sbjct: 2554 -ASMEEARRRQHE---AEEGVRRKQEELQQLEQ 2582



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 163/703 (23%), Positives = 287/703 (40%), Gaps = 155/703 (22%)

Query: 369  EQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVES----- 423
            ++L+AER     E    + H  ++ + +    AQ E        +L+  RL +E+     
Sbjct: 954  DRLMAER-----EYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELKDIRLQLEACETRT 1007

Query: 424  VRKEKVDLSNQLEEE--RRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQ--------L 473
            V + ++ L  +   E  +R  E  + + E E + KG   L+  AEK   L         L
Sbjct: 1008 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1067

Query: 474  EEELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEH 521
              EL L  G++E+++              L+  G        A E+LR  E  L   KE 
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEA 1119

Query: 522  QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSEN 571
            Q     L +     L+A +A + KLRA  E        L+D          ++QQ   E 
Sbjct: 1120 QAVPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1174

Query: 572  MGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE--- 628
               ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E   
Sbjct: 1175 DVEVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESAD 1221

Query: 629  -----LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH---------------- 667
                 L + + + +   AM + + +A+RE+L++ Q  L  ++RH                
Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281

Query: 668  -----------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQA 711
                       ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y    
Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY---- 1337

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHT 771
              I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++  
Sbjct: 1338 --IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1389

Query: 772  HMIESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKS 827
               E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEA 1446

Query: 828  GEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH 887
             E+    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R 
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER- 1502

Query: 888  SPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE 947
                   L R+V     R ++ +++   R   E     +K+++L             A E
Sbjct: 1503 -------LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALE 1543

Query: 948  LLRLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 988
             LRLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1544 ELRLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  100 bits (249), Expect = 7e-21
 Identities = 152/678 (22%), Positives = 288/678 (42%), Gaps = 97/678 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LT  +S+Y + IS T    E   E+++  EQ  AE     AEV  A     ++ +  A  
Sbjct: 1326 LTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
            KAQ E+   E ++++Q      E VR+E+  +  Q ++   + E  Q R   E+  +   
Sbjct: 1383 KAQAEREAKELQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437

Query: 460  ELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASK 519
                 AE+SR L++EEE+ + R ++E  ++     G    +     + LR R     A K
Sbjct: 1438 RQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGGAEGE----LQALRARAEEAEAQK 1489

Query: 520  EHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDN 577
               +E    + R   +++ +  QAEV+   A+  K   E A  K +  QA  E       
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAEAEAAREKQRALQALEE------- 1540

Query: 578  WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHD 637
                L   A + ++ L             +Q E+   + V   ++   +     LQ+K  
Sbjct: 1541 ----LRLQAEEAERRL-------------RQAEVERARQVQVALETAQRSAEAELQSKR- 1582

Query: 638  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRV 697
               A   ++   L   LQE    +A L+     + + QA   R   +EA+ +    +L+ 
Sbjct: 1583 ---ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKA 1638

Query: 698  HELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLV--- 754
            +E  +L ++    AQ     ++ ++ AE +    E  + A  +GK E +++R++ L    
Sbjct: 1639 NEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 755  AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEML 814
             E + Q  E     +     E   +  ET + ++  + L+++L +  +E  A T + + L
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 815  RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD----ASGQLVLISQELLRK 870
             A+++ + +       +++ LL  K R E E  + S K+       +G+   +++E  R 
Sbjct: 1754 EAELAKVRA-------EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR- 1805

Query: 871  ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ--------KLKDDIR-GLREK 921
                  LR L  EA R     E D +R+  +AE  + E+        +LK +    L+EK
Sbjct: 1806 ------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 922  LTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLMSTEDA-----------LRDALDQ 968
                ++ + L++   +    ++  +A     ++ +L     A           + D L Q
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 969  AQQVEKLMEAMRSCPDKA 986
             +QVE+ + A+++  +KA
Sbjct: 1920 RRQVEEEILALKASFEKA 1937



 Score =  100 bits (248), Expect = 9e-21
 Identities = 137/610 (22%), Positives = 258/610 (42%), Gaps = 83/610 (13%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQ---YVAEAEEK 413
            LQ+ L+++Q  ++QL  E +  R    +A     + E+E A  + Q E+       AEE+
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124

Query: 414  LQ---RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLEL------TTV 464
             Q   +A+   E +RKE        +E  R+ +  Q  + ++     ++E        T+
Sbjct: 2125 AQARAQAQAAAEKLRKEAE------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 465  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE 524
             +K+   Q+E+ELT  R ++EE             DH        L +  L   K    E
Sbjct: 2179 RQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQRLKAEATE 2218

Query: 525  SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATSENMGLMDN 577
            +   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +E M  +  
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 578  WKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVMEGIKMEHQL 627
              ++L   A +     Q + EDL         AQQ+ + E      ++AV E  +++ + 
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQEATRLKAEA 2329

Query: 628  ELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQASQHRLEL 683
            EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ A   RL+L
Sbjct: 2330 EL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 684  QEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERLQRAEAQGK 742
            + A+  R  A       E+    +R QA+ I     +  LA ++K+   + L+    Q  
Sbjct: 2388 RVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 743  QEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKETVEGLQDKL 797
             + E LRE +   E   + ++         S+    ++   + +ET   +++    +D L
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 798  NKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA 856
             +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E   R+ H+A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 857  SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIR 916
               +    +EL + E+   +   LL E N+     +  L  E H+A     E+     + 
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 917  GLREKLTGLD 926
              +    G D
Sbjct: 2622 ATKTLPNGRD 2631



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 171/777 (22%), Positives = 309/777 (39%), Gaps = 141/777 (18%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1799 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 446  -QFRVEEESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDA 504
             Q R  EE I    L L    EK+   + E EL L  G I    +  L S        + 
Sbjct: 1918 RQRRQVEEEI----LALKASFEKAAAGKAELELEL--GRIRSNAEDTLRS-------KEQ 1964

Query: 505  AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY------AQEVA 558
            AE+   R+R L+A +E +R      ++ +K+L A +    + +AA E+        +E  
Sbjct: 1965 AELEAARQRQLAAEEERRRREA--EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 559  GLKDKVQQATSENMGLMDNWKSK-------------------LDSLASDHQKSLEDLKAT 599
             L+++ +Q ++  + L      K                   L       Q  L+ L+  
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 600  LNSGP-GAQQKEIGELKAVMEGIKMEHQLELGN---------LQAKHDLETAMHVKEKEA 649
              +    A++ E   ++A  E  +   Q+E             QA+   + A     KEA
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 650  LREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEAQDQR 690
             +E  + AQ E A L++                     +AQ+E + +  RL+L+E   Q+
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 691  RDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK------- 742
                L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +       
Sbjct: 2203 N---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 743  --------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT----KETV 790
                    +E E +++   VAE   +   A   +     +   D++++        KE +
Sbjct: 2260 DNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 791  EGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAELETV 849
            + +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE +  
Sbjct: 2317 QAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 850  SRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW----- 904
               + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E      
Sbjct: 2376 LEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELATQEK 2427

Query: 905  -------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMS 957
                    I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q QL+ 
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QEQLLQ 2486

Query: 958  TEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1010
               AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQQ 2540



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 153/693 (22%), Positives = 288/693 (41%), Gaps = 102/693 (14%)

Query: 357  LQEALKEKQQHIEQLLA-------------ERDLERAEVAKATSHICEVEKEIALLKAQH 403
            +++ L++++Q  E++LA             E +LE   +          +++  L  A+ 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
             Q  AE E + + A   V+     + + + Q +    +VE L+ +VEE    +   E   
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE--- 2029

Query: 464  VAEKSRVLQLEEELTLRRGEIE-------------ELQQCLLHSGPPPPDHPDAAEIL-R 509
              E +R LQL +E   +R + E             ELQQ L             AE   R
Sbjct: 2030 -QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 510  LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANE---------KYAQEVAGL 560
              E    A  + +RE+   R + E+A +  Q+  ++ +A  +         K A++ A  
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 561  KDKVQQATSENMGLMDNWKSKLDSLA-----------------------SDHQKSLED-- 595
            + + +QA        D    K    A                       +DHQK+L D  
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 596  ---LKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLET-AMHVKEKEALR 651
               LKA   +   A+Q+   E +     ++ME   EL  L+A+ + E  A+ +++K+  +
Sbjct: 2209 LQRLKA--EATEAARQRSQVEEELFSVRVQME---ELSKLKARIEAENRALILRDKDNTQ 2263

Query: 652  EKLQEAQEELAGLQRHWRAQLEVQASQ----HRLELQEAQDQRRDAELRVHE-LEKLDVE 706
              LQE  E++  +     A+L V A +     +L  ++   QR  AE  + E ++ +   
Sbjct: 2264 RFLQEEAEKMKQVAEE-AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 707  YRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALC 766
             R +A+A E L++Q  LA+++    +  +   AQ   E     ++ L AE + Q    + 
Sbjct: 2323 TRLKAEA-ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL--EMS 2379

Query: 767  SSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCK 826
            +      +   ++S    R +E  +    +  K+ +E+     +TE+   +   L    +
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435

Query: 827  SGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQEL--LRKERSLNELRVLLLEA 884
               ++ D   +  R   AELE    K    +  L L S+E+  +++E+ L E + L    
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL---- 2491

Query: 885  NRHSPGPERD--LSREVHKAEWRIK-EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 941
             + S   E+D  L RE    + + K EQ  +D++   ++      +++   +Q R  L+ 
Sbjct: 2492 -QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV- 2549

Query: 942  PSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 974
             +S  E  R QH+    E+ +R   ++ QQ+E+
Sbjct: 2550 -ASMEEARRRQHE---AEEGVRRKQEELQQLEQ 2578



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 163/703 (23%), Positives = 287/703 (40%), Gaps = 155/703 (22%)

Query: 369  EQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVES----- 423
            ++L+AER     E    + H  ++ + +    AQ E        +L+  RL +E+     
Sbjct: 950  DRLMAER-----EYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELKDIRLQLEACETRT 1003

Query: 424  VRKEKVDLSNQLEEE--RRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQ--------L 473
            V + ++ L  +   E  +R  E  + + E E + KG   L+  AEK   L         L
Sbjct: 1004 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1063

Query: 474  EEELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEH 521
              EL L  G++E+++              L+  G        A E+LR  E  L   KE 
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEA 1115

Query: 522  QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSEN 571
            Q     L +     L+A +A + KLRA  E        L+D          ++QQ   E 
Sbjct: 1116 QAVPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170

Query: 572  MGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE--- 628
               ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E   
Sbjct: 1171 DVEVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESAD 1217

Query: 629  -----LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH---------------- 667
                 L + + + +   AM + + +A+RE+L++ Q  L  ++RH                
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277

Query: 668  -----------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQA 711
                       ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y    
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY---- 1333

Query: 712  QAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHT 771
              I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++  
Sbjct: 1334 --IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 772  HMIESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKS 827
               E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEA 1442

Query: 828  GEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH 887
             E+    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER- 1498

Query: 888  SPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE 947
                   L R+V     R ++ +++   R   E     +K+++L             A E
Sbjct: 1499 -------LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALE 1539

Query: 948  LLRLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 988
             LRLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1540 ELRLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,068,913
Number of Sequences: 37866
Number of extensions: 1840776
Number of successful extensions: 22283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 341
Number of HSP's successfully gapped in prelim test: 1210
Number of HSP's that attempted gapping in prelim test: 11846
Number of HSP's gapped (non-prelim): 6201
length of query: 1011
length of database: 18,247,518
effective HSP length: 112
effective length of query: 899
effective length of database: 14,006,526
effective search space: 12591866874
effective search space used: 12591866874
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.