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Search of human proteins with 145386578
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145386578 torsin family 2, member A isoform a [Homo sapiens]
(321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145386578 torsin family 2, member A isoform a [Homo sapiens] 658 0.0
gi|145386549 torsin family 2, member A isoform b [Homo sapiens] 412 e-115
gi|197313700 torsin family 2, member A isoform c [Homo sapiens] 412 e-115
gi|4557541 torsin A [Homo sapiens] 275 4e-74
gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens] 274 9e-74
gi|115647957 torsin family 3, member A [Homo sapiens] 214 6e-56
gi|197313702 torsin family 2, member A isoform d [Homo sapiens] 108 5e-24
gi|116063568 hypothetical protein LOC54863 [Homo sapiens] 77 3e-14
gi|13540606 caseinolytic peptidase B [Homo sapiens] 41 0.001
gi|223005897 GPN-loop GTPase 1 isoform a [Homo sapiens] 32 0.76
gi|224500884 hypothetical protein LOC339541 [Homo sapiens] 31 1.3
gi|239746778 PREDICTED: hypothetical protein XP_002343847 [Homo ... 29 4.9
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 29 6.4
gi|41872646 cullin 7 [Homo sapiens] 28 8.4
gi|4507609 tumor necrosis factor (ligand) superfamily, member 9 ... 28 8.4
>gi|145386578 torsin family 2, member A isoform a [Homo sapiens]
Length = 321
Score = 658 bits (1697), Expect = 0.0
Identities = 321/321 (100%), Positives = 321/321 (100%)
Query: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL
Sbjct: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
Query: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV
Sbjct: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
Query: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS
Sbjct: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
Query: 181 SWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEILLQELEPVISRAVLDNPH 240
SWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEILLQELEPVISRAVLDNPH
Sbjct: 181 SWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEILLQELEPVISRAVLDNPH 240
Query: 241 HGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAVLDSTTFFPE 300
HGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAVLDSTTFFPE
Sbjct: 241 HGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAVLDSTTFFPE 300
Query: 301 DEQLFSSNGCKTVASRIAFFL 321
DEQLFSSNGCKTVASRIAFFL
Sbjct: 301 DEQLFSSNGCKTVASRIAFFL 321
>gi|145386549 torsin family 2, member A isoform b [Homo sapiens]
Length = 253
Score = 412 bits (1060), Expect = e-115
Identities = 197/197 (100%), Positives = 197/197 (100%)
Query: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL
Sbjct: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
Query: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV
Sbjct: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
Query: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS
Sbjct: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
Query: 181 SWVVYGTNYRKAIFIFI 197
SWVVYGTNYRKAIFIFI
Sbjct: 181 SWVVYGTNYRKAIFIFI 197
>gi|197313700 torsin family 2, member A isoform c [Homo sapiens]
Length = 242
Score = 412 bits (1060), Expect = e-115
Identities = 197/197 (100%), Positives = 197/197 (100%)
Query: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL
Sbjct: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL 60
Query: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV
Sbjct: 61 AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV 120
Query: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS
Sbjct: 121 HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS 180
Query: 181 SWVVYGTNYRKAIFIFI 197
SWVVYGTNYRKAIFIFI
Sbjct: 181 SWVVYGTNYRKAIFIFI 197
>gi|4557541 torsin A [Homo sapiens]
Length = 332
Score = 275 bits (703), Expect = 4e-74
Identities = 125/269 (46%), Positives = 191/269 (71%)
Query: 52 LECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLF 111
L+ DL +L GQHLAK +++ A+ F+ +P P KPL LSLHGWTGTGK++VS ++A ++
Sbjct: 61 LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
Query: 112 QGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLM 171
+GGL S VH F LHFPH S+I YK L+ W++GN++AC RS+F+FDEMDKM GL+
Sbjct: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
Query: 172 EVLRPFLGSSWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEILLQELEPVI 231
+ ++PFL +V G +Y+KA+FIF+SN G E+I VAL+ WRS + RE+I L+++E +
Sbjct: 181 DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL 240
Query: 232 SRAVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAV 291
S +V +N + GF +S +++ L+D VPFLPL+ H++ C+ E+ G E +++V V
Sbjct: 241 SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV 300
Query: 292 LDSTTFFPEDEQLFSSNGCKTVASRIAFF 320
+ TFFP++E++FS GCKTV +++ ++
Sbjct: 301 AEEMTFFPKEERVFSDKGCKTVFTKLDYY 329
>gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens]
Length = 336
Score = 274 bits (700), Expect = 9e-74
Identities = 133/302 (44%), Positives = 191/302 (63%)
Query: 18 LGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAF 77
+G SA + C C + + L+ DL + L GQHLA ++ KAL F
Sbjct: 34 IGAASAITGYLSYNDIYCRFAECCREERPLNASALKLDLEEKLFGQHLATEVIFKALTGF 93
Query: 78 VRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIER 137
+ P KPL LSLHGW GTGK++VS ++A L GL+S VH F LHFPH I+
Sbjct: 94 RNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKL 153
Query: 138 YKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFI 197
Y+ L+ W++GN++AC S+F+FDEMDK+ PG+++ ++PFL V G +YRKAIFIF+
Sbjct: 154 YQDQLQKWIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFL 213
Query: 198 SNTGGEQINQVALEAWRSRRDREEILLQELEPVISRAVLDNPHHGFSNSGIMEERLLDAV 257
SN GG+ I + AL+ WR+ R RE+I L++LEPV+S V +N H G +SG++++ L+D
Sbjct: 214 SNAGGDLITKTALDFWRAGRKREDIQLKDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYF 273
Query: 258 VPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAVLDSTTFFPEDEQLFSSNGCKTVASRI 317
+PFLPL+ HV+ CV E+ G +++V V + TFFP DE+++S GCKTV SR+
Sbjct: 274 IPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRVAEEMTFFPRDEKIYSDKGCKTVQSRL 333
Query: 318 AF 319
F
Sbjct: 334 DF 335
>gi|115647957 torsin family 3, member A [Homo sapiens]
Length = 397
Score = 214 bits (546), Expect = 6e-56
Identities = 108/290 (37%), Positives = 169/290 (58%), Gaps = 19/290 (6%)
Query: 42 ECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSY 101
+C + GLE DL L GQHL + LV++ ++ ++ P P K L LS HGW+GTGK++
Sbjct: 116 DCRISNNFTGLEWDLNVRLHGQHLVQQLVLRTVRGYLETPQPEKALALSFHGWSGTGKNF 175
Query: 102 VSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFD 161
V+ +L L++ GL S V F HFPHP +++ YK+ L S ++ C ++LF+FD
Sbjct: 176 VARMLVENLYRDGLMSDCVRMFIATFHFPHPKYVDLYKEQLMSQIRETQQLCHQTLFIFD 235
Query: 162 EMDKMPPGLMEVLRPFL----------GSSWVVYGTNYRKAIFIFISNTGGEQINQVALE 211
E +K+ PGL+EVL P L S W IF+F+SN G+ IN+V L+
Sbjct: 236 EAEKLHPGLLEVLGPHLERRAPEGHRAESPW---------TIFLFLSNLRGDIINEVVLK 286
Query: 212 AWRSRRDREEILLQELEPVISRAVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHC 271
++ REEI ++ LEP + +++ +GF +S +++E L+D +PFLPL+ HVR C
Sbjct: 287 LLKAGWSREEITMEHLEPHLQAEIVETIDNGFGHSRLVKENLIDYFIPFLPLEYRHVRLC 346
Query: 272 VLNELAQLGLEPRDEVVQAVLDSTTFFPEDEQLFSSNGCKTVASRIAFFL 321
+ L ++E + + + P++EQLFSS GCK+++ RI +FL
Sbjct: 347 ARDAFLSQELLYKEETLDEIAQMMVYVPKEEQLFSSQGCKSISQRINYFL 396
>gi|197313702 torsin family 2, member A isoform d [Homo sapiens]
Length = 72
Score = 108 bits (271), Expect = 5e-24
Identities = 50/50 (100%), Positives = 50/50 (100%)
Query: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLP 50
MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLP
Sbjct: 1 MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLP 50
>gi|116063568 hypothetical protein LOC54863 [Homo sapiens]
Length = 423
Score = 76.6 bits (187), Expect = 3e-14
Identities = 73/286 (25%), Positives = 126/286 (44%), Gaps = 26/286 (9%)
Query: 46 RPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSL 105
R DL GLE L + + GQ A + +V ++ ++ ++PL+L+LHG +G GKS+V L
Sbjct: 147 RYDLDGLEKALQRAVFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGRL 206
Query: 106 LAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRS----LFLFD 161
LA + S V + H P + +++L V + L + D
Sbjct: 207 LARHFRSVLEDSALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLD 266
Query: 162 EMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFISNTGGEQINQVALE-AWRSR---- 216
+++ MP L++ L FL ++ AI++ +S GG ++ + L+ A R+
Sbjct: 267 DVELMPRPLLDELHGFLQPQ---RSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRP 323
Query: 217 ---RDREEILLQELEPVISR--AVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHC 271
R E Q E + + AVL H + + A+VPFL L + V C
Sbjct: 324 DGFRSAEAAAAQAEEDLRASLLAVLSREHPLWQAA---------AIVPFLLLDKRDVVSC 374
Query: 272 VLNELAQLGLEPRDEVVQAVLDSTTFFPEDEQLFSSNGCKTVASRI 317
+E+A G P + + +F+ + F+ GCK V + +
Sbjct: 375 FRDEMAGEGFFPDQARAENLAAQLSFYRVAGREFAVTGCKQVVATV 420
>gi|13540606 caseinolytic peptidase B [Homo sapiens]
Length = 707
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/174 (24%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 52 LECDLAQHLAGQHLAKALVVKALKAFVRDPAPTK-PLVLSLHGWTGTGKSYVSSLLAHYL 110
LE L +H+ GQ A A V A++ + PLV G +G GK+ ++ A Y+
Sbjct: 339 LEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYM 398
Query: 111 FQGGLRS---------PRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFD 161
+ + H + + P P ++ + + L C ++ LFD
Sbjct: 399 HKDAKKGFIRLDMSEFQERHEVAKFIGSP-PGYVGHEEG---GQLTKKLKQCPNAVVLFD 454
Query: 162 EMDKMPPGLMEVLRPFLGSSWVVYG----TNYRKAIFIFISNTGGEQINQVALE 211
E+DK P ++ ++ + G + + AIFI SN ++I Q AL+
Sbjct: 455 EVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQ 508
>gi|223005897 GPN-loop GTPase 1 isoform a [Homo sapiens]
Length = 388
Score = 32.0 bits (71), Expect = 0.76
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 83 PTKPLVLSLHGWTGTGK-SYVSSLLAHYLFQGGLRSPRVHHFSPVLH-FPHPSHIE---- 136
P P+ L + G G+GK ++V L H QG P V + P +H P P++I+
Sbjct: 30 PRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQG--TPPYVINLDPAVHEVPFPANIDIRDT 87
Query: 137 -RYKKDLKSWVQGNLTACGRSLFLF 160
+YK+ +K + G SL LF
Sbjct: 88 VKYKEVMKQYGLGPNGGIVTSLNLF 112
>gi|224500884 hypothetical protein LOC339541 [Homo sapiens]
Length = 440
Score = 31.2 bits (69), Expect = 1.3
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 234 AVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAV 291
A + N H SNS + L+ V PL HVR C+ EL QL L +++ +
Sbjct: 331 AAMGNTDH--SNSQRLASLTLECFVQMFPLVAEHVRKCMGEELYQLFLSNAEDLYMKI 386
>gi|239746778 PREDICTED: hypothetical protein XP_002343847 [Homo
sapiens]
Length = 215
Score = 29.3 bits (64), Expect = 4.9
Identities = 18/46 (39%), Positives = 19/46 (41%), Gaps = 2/46 (4%)
Query: 17 LLGLVSAAAAAWDLASLRCTLGA-FCECDFRPDLPGLEC-DLAQHL 60
L GLV+ A W LRC G C F P P C L HL
Sbjct: 156 LAGLVAGAGCRWRALRLRCRHGRHLCRSPFLPASPSTNCFSLLGHL 201
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 28.9 bits (63), Expect = 6.4
Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 9/84 (10%)
Query: 232 SRAVLDNPHHGFSN-----SGIMEERLLDAVVPFLPLQRHHVRHCV--LNELAQLGLEPR 284
S A L + +G N +G EE + + Q HH+ HC+ L+ L +P
Sbjct: 438 SNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPL 497
Query: 285 DEVVQAVLDSTTFFPEDEQLFSSN 308
V + + + F DEQ+F N
Sbjct: 498 LSVRTSTIKNHEFI--DEQMFEQN 519
>gi|41872646 cullin 7 [Homo sapiens]
Length = 1698
Score = 28.5 bits (62), Expect = 8.4
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 1/55 (1%)
Query: 62 GQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLR 116
G H+ + LV L+A+ + P P + LV SL + + V S + H L +G LR
Sbjct: 1582 GLHIDQ-LVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLR 1635
>gi|4507609 tumor necrosis factor (ligand) superfamily, member 9
[Homo sapiens]
Length = 254
Score = 28.5 bits (62), Expect = 8.4
Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 16/96 (16%)
Query: 2 AAATRGCR--PWGSLLGLLGLVSAAAAA-------WDLASLRCTLGAFCECDFR------ 46
A R CR PW + GLL L+ AAA W ++ R + G+ R
Sbjct: 18 APRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELS 77
Query: 47 PDLPGLECDLAQHLAGQHLAK-ALVVKALKAFVRDP 81
PD P DL Q + Q +A+ L++ ++ DP
Sbjct: 78 PDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDP 113
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,156,191
Number of Sequences: 37866
Number of extensions: 612379
Number of successful extensions: 1660
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1647
Number of HSP's gapped (non-prelim): 15
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.