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Search of human proteins with 109633028
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109633028 serine/threonine protein kinase MST4 isoform 2
[Homo sapiens]
(339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 681 0.0
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 654 0.0
gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Hom... 463 e-131
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 441 e-124
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 441 e-124
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 436 e-122
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 241 9e-64
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 233 1e-61
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 217 1e-56
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 217 1e-56
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 217 1e-56
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 217 1e-56
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 217 1e-56
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 217 1e-56
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 217 1e-56
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 217 1e-56
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 206 3e-53
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 206 3e-53
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 206 3e-53
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 206 3e-53
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 202 3e-52
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 202 3e-52
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 202 3e-52
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 202 3e-52
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 202 5e-52
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 202 5e-52
gi|145275208 myosin IIIA [Homo sapiens] 201 1e-51
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 196 3e-50
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 196 3e-50
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 196 3e-50
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 681 bits (1757), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MAHSPVAVQVPGMQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHS 60
MAHSPVAVQVPGMQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHS
Sbjct: 1 MAHSPVAVQVPGMQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHS 60
Query: 61 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 120
EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD
Sbjct: 61 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 120
Query: 121 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK 180
SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK
Sbjct: 121 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK 180
Query: 181 DPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE 240
DPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE
Sbjct: 181 DPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE 240
Query: 241 NNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQA 300
NNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQA
Sbjct: 241 NNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQA 300
Query: 301 IEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 339
IEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 301 IEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 339
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 654 bits (1688), Expect = 0.0
Identities = 325/327 (99%), Positives = 327/327 (100%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
++GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 149
Query: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA
Sbjct: 150 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 209
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL
Sbjct: 210 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 269
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 252
KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV
Sbjct: 270 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 329
Query: 253 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 312
RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE
Sbjct: 330 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 389
Query: 313 AACPGITDKMVKKLIEKFQKCSADESP 339
AACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 390 AACPGITDKMVKKLIEKFQKCSADESP 416
Score = 35.4 bits (80), Expect = 0.073
Identities = 19/34 (55%), Positives = 24/34 (70%), Gaps = 5/34 (14%)
Query: 1 MAHSPVAVQVPGMQGS-----KLWIIMEYLGGGS 29
MAHSPVAVQVPGMQ + +L+ +E +G GS
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGS 34
>gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Homo
sapiens]
Length = 354
Score = 463 bits (1192), Expect = e-131
Identities = 252/327 (77%), Positives = 256/327 (78%), Gaps = 62/327 (18%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
++GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 149
Query: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK TA
Sbjct: 150 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKRP------TA 203
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
EL K + I KN+ T
Sbjct: 204 KELLKHK-------------FIVKNSKKT------------------------------- 219
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 252
SYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV
Sbjct: 220 ------------SYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 267
Query: 253 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 312
RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE
Sbjct: 268 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 327
Query: 313 AACPGITDKMVKKLIEKFQKCSADESP 339
AACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 328 AACPGITDKMVKKLIEKFQKCSADESP 354
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 441 bits (1133), Expect = e-124
Identities = 228/336 (67%), Positives = 275/336 (81%), Gaps = 17/336 (5%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
++ +KLWIIMEYLGGGSALDLL GP DE QIAT+L+EILKGLDYLHSEKKIHRDIKAAN
Sbjct: 90 LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAAN 149
Query: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
VLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+QSAYDSKADIWSLGITA
Sbjct: 150 VLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITA 209
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
IELA+GEPP+S++HPM+VLFLIPKNNPPTL G+++K KEF++ACLNK+PSFRPTAKELL
Sbjct: 210 IELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELL 269
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN--NTHPEWSFT 250
KHKFI++N+KKTSYLTELIDR+KRWKAE S D+S SE SD+E+ + + + +W F
Sbjct: 270 KHKFILRNAKKTSYLTELIDRYKRWKAE-QSHDDSSSEDSDAETDGQASGGSDSGDWIF- 327
Query: 251 TVRKKPDPKKVQNGAEQ--DLVQT----------LSCLSMIITPAFAELKQQDENNASRN 298
T+R+K DPK ++NGA Q DL + CLS II+P FAELK++ +
Sbjct: 328 TIREK-DPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNL 386
Query: 299 QAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 334
+IEEL +I +AE ACPGI+D MV +L+++ Q+ S
Sbjct: 387 GSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 422
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 441 bits (1133), Expect = e-124
Identities = 228/336 (67%), Positives = 275/336 (81%), Gaps = 17/336 (5%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
++ +KLWIIMEYLGGGSALDLL GP DE QIAT+L+EILKGLDYLHSEKKIHRDIKAAN
Sbjct: 102 LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAAN 161
Query: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
VLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+QSAYDSKADIWSLGITA
Sbjct: 162 VLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITA 221
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
IELA+GEPP+S++HPM+VLFLIPKNNPPTL G+++K KEF++ACLNK+PSFRPTAKELL
Sbjct: 222 IELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELL 281
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN--NTHPEWSFT 250
KHKFI++N+KKTSYLTELIDR+KRWKAE S D+S SE SD+E+ + + + +W F
Sbjct: 282 KHKFILRNAKKTSYLTELIDRYKRWKAE-QSHDDSSSEDSDAETDGQASGGSDSGDWIF- 339
Query: 251 TVRKKPDPKKVQNGAEQ--DLVQT----------LSCLSMIITPAFAELKQQDENNASRN 298
T+R+K DPK ++NGA Q DL + CLS II+P FAELK++ +
Sbjct: 340 TIREK-DPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNL 398
Query: 299 QAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 334
+IEEL +I +AE ACPGI+D MV +L+++ Q+ S
Sbjct: 399 GSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 434
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 436 bits (1120), Expect = e-122
Identities = 221/332 (66%), Positives = 263/332 (79%), Gaps = 11/332 (3%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
++ +KLWIIMEYLGGGSALDLL+ GP +E IAT+L+EILKGLDYLHSE+KIHRDIKAAN
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAAN 145
Query: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+QSAYD KADIWSLGITA
Sbjct: 146 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITA 205
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
IELAKGEPPNSD+HPMRVLFLIPKN+PPTL G +K FKEF++ACLNKDP FRPTAKELL
Sbjct: 206 IELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELL 265
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSF-TT 251
KHKFI + +KKTS+LTELIDR+KRWK+EGH +ES SE SD + + + P W+F T
Sbjct: 266 KHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDGEAEDGEQGPIWTFPPT 324
Query: 252 VRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAELKQQDENNASRNQAIE 302
+R P K Q AE Q S CLS ++ P F ELK++ + + A+E
Sbjct: 325 IRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALE 384
Query: 303 ELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 334
ELE + ++AE +CPGI+DK++ L+E+ Q+ S
Sbjct: 385 ELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 241 bits (614), Expect = 9e-64
Identities = 127/247 (51%), Positives = 166/247 (67%), Gaps = 7/247 (2%)
Query: 4 SPVAVQVPG--MQGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLH 59
SP V+ G + + LWI+MEY G GS D+ LR E +IAT+LK LKGL+YLH
Sbjct: 79 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 138
Query: 60 SEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 119
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y
Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 198
Query: 120 DSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDAC 177
+ ADIWSLGIT+IE+A+G+PP +D+HPMR +F+IP N PPT ++ F +F+ C
Sbjct: 199 NCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 258
Query: 178 LNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSEST 237
L K+P R TA +LL+H FI KN+K S L +LI KA+ H + + + E + S
Sbjct: 259 LVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSD 317
Query: 238 SRENNTH 244
E ++H
Sbjct: 318 EDELDSH 324
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 233 bits (595), Expect = 1e-61
Identities = 124/243 (51%), Positives = 166/243 (68%), Gaps = 12/243 (4%)
Query: 4 SPVAVQVPG--MQGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLH 59
SP V+ G + + LWI+MEY G GS D+ LR E +IAT+L+ LKGL+YLH
Sbjct: 82 SPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLH 141
Query: 60 SEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 119
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y
Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 201
Query: 120 DSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDAC 177
+ ADIWSLGITAIE+A+G+PP +D+HPMR +F+IP N PPT ++ +F +F+ C
Sbjct: 202 NCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261
Query: 178 LNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELID-----RFKRWKAEGHSDDESDSEGS 232
L K P R TA +LL+H F V+++K S L +LI+ + KR +++ D+ D E S
Sbjct: 262 LVKSPEQRATATQLLQHPF-VRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENS 320
Query: 233 DSE 235
+ +
Sbjct: 321 EED 323
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 217 bits (552), Expect = 1e-56
Identities = 116/242 (47%), Positives = 154/242 (63%), Gaps = 10/242 (4%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
PGM +LW++ME+ G GS DL+ + E IA + +EIL+GL +LH K IHRD
Sbjct: 95 PGMD-DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD K
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFK 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L ++K F+ FI++CL K+
Sbjct: 214 SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
S RP ++L+KH FI + +L D R K + DE++ E S SE EN
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 242 NT 243
++
Sbjct: 334 DS 335
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 206 bits (523), Expect = 3e-53
Identities = 121/305 (39%), Positives = 176/305 (57%), Gaps = 30/305 (9%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH+ K IHRD
Sbjct: 94 PPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F +FID CL K
Sbjct: 214 SDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKT 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
RP ++LLK FI + +L D R + + +E++ E S SE E+
Sbjct: 274 YLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EED 330
Query: 242 NTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAI 301
++H E + +P + N + ++ F L+Q++++N+ +
Sbjct: 331 DSHGE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQ 372
Query: 302 EELEK 306
++L++
Sbjct: 373 QQLQQ 377
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 206 bits (523), Expect = 3e-53
Identities = 121/305 (39%), Positives = 176/305 (57%), Gaps = 30/305 (9%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH+ K IHRD
Sbjct: 94 PPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F +FID CL K
Sbjct: 214 SDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKT 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
RP ++LLK FI + +L D R + + +E++ E S SE E+
Sbjct: 274 YLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EED 330
Query: 242 NTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAI 301
++H E + +P + N + ++ F L+Q++++N+ +
Sbjct: 331 DSHGE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQ 372
Query: 302 EELEK 306
++L++
Sbjct: 373 QQLQQ 377
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 206 bits (523), Expect = 3e-53
Identities = 121/305 (39%), Positives = 176/305 (57%), Gaps = 30/305 (9%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH+ K IHRD
Sbjct: 94 PPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F +FID CL K
Sbjct: 214 SDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKT 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
RP ++LLK FI + +L D R + + +E++ E S SE E+
Sbjct: 274 YLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EED 330
Query: 242 NTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAI 301
++H E + +P + N + ++ F L+Q++++N+ +
Sbjct: 331 DSHGE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQ 372
Query: 302 EELEK 306
++L++
Sbjct: 373 QQLQQ 377
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 206 bits (523), Expect = 3e-53
Identities = 121/305 (39%), Positives = 176/305 (57%), Gaps = 30/305 (9%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH+ K IHRD
Sbjct: 94 PPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F +FID CL K
Sbjct: 214 SDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKT 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSREN 241
RP ++LLK FI + +L D R + + +E++ E S SE E+
Sbjct: 274 YLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EED 330
Query: 242 NTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAI 301
++H E + +P + N + ++ F L+Q++++N+ +
Sbjct: 331 DSHGE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQ 372
Query: 302 EELEK 306
++L++
Sbjct: 373 QQLQQ 377
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 202 bits (515), Expect = 3e-52
Identities = 110/239 (46%), Positives = 146/239 (61%), Gaps = 9/239 (3%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH IHRD
Sbjct: 94 PPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F FI+ CL K+
Sbjct: 214 SDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE 240
RP+ ++LLKH FI + +L D R + + DE++ E S SE E
Sbjct: 274 YMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE 332
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 202 bits (515), Expect = 3e-52
Identities = 110/239 (46%), Positives = 146/239 (61%), Gaps = 9/239 (3%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH IHRD
Sbjct: 94 PPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F FI+ CL K+
Sbjct: 214 SDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE 240
RP+ ++LLKH FI + +L D R + + DE++ E S SE E
Sbjct: 274 YMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE 332
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 202 bits (515), Expect = 3e-52
Identities = 110/239 (46%), Positives = 146/239 (61%), Gaps = 9/239 (3%)
Query: 11 PGMQGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
P +LW++ME+ G GS DL++ E IA + +EIL+GL +LH IHRD
Sbjct: 94 PPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRD 153
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----QQSAYDSK 122
IK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAPEVI + YD +
Sbjct: 154 IKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYR 213
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKD 181
+D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L ++K F FI+ CL K+
Sbjct: 214 SDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKN 273
Query: 182 PSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRE 240
RP+ ++LLKH FI + +L D R + + DE++ E S SE E
Sbjct: 274 YMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE 332
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 202 bits (515), Expect = 3e-52
Identities = 118/265 (44%), Positives = 165/265 (62%), Gaps = 18/265 (6%)
Query: 13 MQGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAA 71
++ KLWI ME+ GGGS D+ GP E QIA + +E L+GL YLHS+ K+HRDIK A
Sbjct: 81 LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGA 140
Query: 72 NVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQSAYDSKADIWSL 128
N+LL++ G VKLADFGV+ Q+T T KR +F+GTP+WMAPEV ++ Y+ D+W++
Sbjct: 141 NILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAV 200
Query: 129 GITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEFIDACLNKDPSF 184
GITAIELA+ +PP D+HPMR LFL+ K+N PP L ++ SF F+ L K+P
Sbjct: 201 GITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKK 260
Query: 185 RPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSD-DESDSEGSDS-----ESTS 238
RPTA++LL+H F+ ++ + S EL+D+ + D D+ D E + STS
Sbjct: 261 RPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTS 319
Query: 239 ---RENNTHPEWSFTTVRKKPDPKK 260
RE T E +F V+ P +K
Sbjct: 320 RNVREEKTRSEITFGQVKFDPPLRK 344
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 202 bits (513), Expect = 5e-52
Identities = 104/222 (46%), Positives = 141/222 (63%), Gaps = 8/222 (3%)
Query: 17 KLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLL 75
KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH++ K+HRDIK AN+LL
Sbjct: 89 KLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL 148
Query: 76 SEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQSAYDSKADIWSLGITA 132
++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV + Y+ DIW++GITA
Sbjct: 149 TDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITA 208
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEFIDACLNKDPSFRPTA 188
IEL + +PP D+HPMR LFL+ K+N PP L ++ +F F+ L K+P RPTA
Sbjct: 209 IELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTA 268
Query: 189 KELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 230
+ LL H F+ + + EL+D+ H + D +
Sbjct: 269 ERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 202 bits (513), Expect = 5e-52
Identities = 104/222 (46%), Positives = 141/222 (63%), Gaps = 8/222 (3%)
Query: 17 KLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLL 75
KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH++ K+HRDIK AN+LL
Sbjct: 89 KLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL 148
Query: 76 SEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQSAYDSKADIWSLGITA 132
++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV + Y+ DIW++GITA
Sbjct: 149 TDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITA 208
Query: 133 IELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEFIDACLNKDPSFRPTA 188
IEL + +PP D+HPMR LFL+ K+N PP L ++ +F F+ L K+P RPTA
Sbjct: 209 IELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTA 268
Query: 189 KELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 230
+ LL H F+ + + EL+D+ H + D +
Sbjct: 269 ERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 201 bits (510), Expect = 1e-51
Identities = 106/214 (49%), Positives = 135/214 (63%), Gaps = 12/214 (5%)
Query: 13 MQGSKLWIIMEYLGGGSALDLL-----RAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
+ G KLW+++E GGS DL+ R E IA +L E L GL +LH+ K IHRD
Sbjct: 91 VNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRD 150
Query: 68 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ-----QSAYDSK 122
+K N+LL+ +G VKL DFGV+ QLT T+ +RNT VGTPFWMAPEVI + YD++
Sbjct: 151 VKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDAR 210
Query: 123 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACLNK 180
D WSLGITAIEL G+PP +D+HPMR LF IP+N PP L ++ F +FI CL K
Sbjct: 211 CDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTK 270
Query: 181 DPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRF 214
D RPT ELL+HKFI + K L + + F
Sbjct: 271 DYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEF 304
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 196 bits (497), Expect = 3e-50
Identities = 101/210 (48%), Positives = 135/210 (64%), Gaps = 3/210 (1%)
Query: 15 GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVL 74
G +LW++MEYL GGS D++ DE QIA + +E L+ L++LHS + IHRDIK+ N+L
Sbjct: 337 GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNIL 396
Query: 75 LSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIE 134
L G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY K DIWSLGI AIE
Sbjct: 397 LGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE 456
Query: 135 LAKGEPPNSDMHPMRVLFLIPKNNPPTLVG--DFTKSFKEFIDACLNKDPSFRPTAKELL 192
+ +GEPP + +P+R L+LI N P L + F++F++ CL D R +AKELL
Sbjct: 457 MIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
Query: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGH 222
+H+F+ K +K S LT LI K H
Sbjct: 517 QHQFL-KIAKPLSSLTPLIAAAKEATKNNH 545
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 196 bits (497), Expect = 3e-50
Identities = 100/199 (50%), Positives = 132/199 (66%), Gaps = 3/199 (1%)
Query: 15 GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVL 74
G +LW++MEYL GGS D++ DE QIA + +E L+ LD+LHS + IHRDIK+ N+L
Sbjct: 350 GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL 409
Query: 75 LSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIE 134
L G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY K DIWSLGI AIE
Sbjct: 410 LGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE 469
Query: 135 LAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACLNKDPSFRPTAKELL 192
+ +GEPP + +P+R L+LI N P L + F++F++ CL D R +AKELL
Sbjct: 470 MVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Query: 193 KHKFIVKNSKKTSYLTELI 211
+H F+ K +K S LT LI
Sbjct: 530 QHPFL-KLAKPLSSLTPLI 547
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 196 bits (497), Expect = 3e-50
Identities = 100/199 (50%), Positives = 132/199 (66%), Gaps = 3/199 (1%)
Query: 15 GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVL 74
G +LW++MEYL GGS D++ DE QIA + +E L+ LD+LHS + IHRDIK+ N+L
Sbjct: 356 GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL 415
Query: 75 LSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIE 134
L G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY K DIWSLGI AIE
Sbjct: 416 LGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE 475
Query: 135 LAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACLNKDPSFRPTAKELL 192
+ +GEPP + +P+R L+LI N P L + F++F++ CL D R +AKELL
Sbjct: 476 MVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 535
Query: 193 KHKFIVKNSKKTSYLTELI 211
+H F+ K +K S LT LI
Sbjct: 536 QHPFL-KLAKPLSSLTPLI 553
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,248,154
Number of Sequences: 37866
Number of extensions: 577790
Number of successful extensions: 3679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 1777
Number of HSP's gapped (non-prelim): 990
length of query: 339
length of database: 18,247,518
effective HSP length: 103
effective length of query: 236
effective length of database: 14,347,320
effective search space: 3385967520
effective search space used: 3385967520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.