Search of human proteins with 94536780

Search of human proteins with 94536780

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94536780 DCN1, defective in cullin neddylation 1, domain
containing 4 isoform 2 [Homo sapiens]
         (257 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94536780 DCN1, defective in cullin neddylation 1, domain cont...   535   e-152
gi|94536778 DCN1, defective in cullin neddylation 1, domain cont...   518   e-147
gi|14150015 DCN1, defective in cullin neddylation 1, domain cont...   271   4e-73
gi|62122952 DCN1, defective in cullin neddylation 1, domain cont...   114   8e-26
gi|36030883 RP42 homolog [Homo sapiens]                               107   1e-23
gi|27735047 DCN1, defective in cullin neddylation 1, domain cont...    94   2e-19
gi|168229156 NFKB activating protein [Homo sapiens]                    32   0.71 
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F...    32   0.71 
gi|7427519 minichromosome maintenance complex component 6 [Homo ...    31   0.93 
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        31   0.93 
gi|117320550 hypothetical protein LOC400566 [Homo sapiens]             30   1.6  
gi|215982794 myosin VA isoform 2 [Homo sapiens]                        29   3.5  
gi|215982791 myosin VA isoform 1 [Homo sapiens]                        29   3.5  
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]    28   6.0  
gi|115527120 nebulin [Homo sapiens]                                    28   6.0  
gi|110630018 eukaryotic translation initiation factor 4 gamma, 2...    28   6.0  
gi|4503539 eukaryotic translation initiation factor 4 gamma, 2 i...    28   6.0  

>gi|94536780 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 2 [Homo sapiens]
          Length = 257

 Score =  535 bits (1379), Expect = e-152
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV 60
           MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV
Sbjct: 1   MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV 60

Query: 61  MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV 120
           MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV
Sbjct: 61  MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV 120

Query: 121 GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL 180
           GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL
Sbjct: 121 GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL 180

Query: 181 DYLRSFLNDSTNFKLIYRYAFDFARQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAW 240
           DYLRSFLNDSTNFKLIYRYAFDFARQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAW
Sbjct: 181 DYLRSFLNDSTNFKLIYRYAFDFARQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAW 240

Query: 241 PVLLDEFVEWYKDKQMS 257
           PVLLDEFVEWYKDKQMS
Sbjct: 241 PVLLDEFVEWYKDKQMS 257


>gi|94536778 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 1 [Homo sapiens]
          Length = 292

 Score =  518 bits (1333), Expect = e-147
 Identities = 257/292 (88%), Positives = 257/292 (88%), Gaps = 35/292 (11%)

Query: 1   MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV 60
           MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV
Sbjct: 1   MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV 60

Query: 61  MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV 120
           MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV
Sbjct: 61  MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV 120

Query: 121 GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL 180
           GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL
Sbjct: 121 GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL 180

Query: 181 DYLRSFLNDSTNFKLIYRYAFDFAR----------------------------------- 205
           DYLRSFLNDSTNFKLIYRYAFDFAR                                   
Sbjct: 181 DYLRSFLNDSTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLE 240

Query: 206 QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS 257
           QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS
Sbjct: 241 QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS 292


>gi|14150015 DCN1, defective in cullin neddylation 1, domain
           containing 5 [Homo sapiens]
          Length = 237

 Score =  271 bits (693), Expect = 4e-73
 Identities = 139/237 (58%), Positives = 163/237 (68%), Gaps = 40/237 (16%)

Query: 61  MPPRKKRRP-----ASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAG 115
           MP +KKR+      A  +D   KK +  S  R     R+ + EE FSSK+CL WFYEYAG
Sbjct: 1   MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG 60

Query: 116 TDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEK 175
            D+VVGPEGMEKFCEDIGVEPEN++MLVLAWKL+A++MG+FT +EWLKGMTSLQCD TEK
Sbjct: 61  PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK 120

Query: 176 LRNTLDYLRSFLNDSTNFKLIYRYAFDFAR------------------------------ 205
           L+N  D+LRS LND ++FK IYRYAFDFAR                              
Sbjct: 121 LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF 180

Query: 206 -----QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS 257
                QSKY+V+NKDQW NVLEFSRT++ DLSNYDEDGAWPVLLDEFVEW K +Q S
Sbjct: 181 YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS 237


>gi|62122952 DCN1, defective in cullin neddylation 1, domain
           containing 2 [Homo sapiens]
          Length = 259

 Score =  114 bits (285), Expect = 8e-26
 Identities = 65/205 (31%), Positives = 101/205 (49%), Gaps = 37/205 (18%)

Query: 83  DSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDV--VGPEGMEKFCEDIGVEPENVV 140
           DS ++  DS   ++   A   K+    +  Y    D   +G +G+++FC+D+ ++P ++ 
Sbjct: 42  DSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASIS 101

Query: 141 MLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLRSFLNDSTNFKLIYRYA 200
           +LV+AWK  A     F+ +E+L GMT L CD+ EKL+  L  L   L D+  FK  Y++ 
Sbjct: 102 VLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFT 161

Query: 201 FDFARQSKYK-----------------------------------VINKDQWCNVLEFSR 225
           F FA+    K                                    I +D W  +L+F  
Sbjct: 162 FTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGN 221

Query: 226 TINLDLSNYDEDGAWPVLLDEFVEW 250
            I  D+SNYDE+GAWPVL+D+FVE+
Sbjct: 222 MIADDMSNYDEEGAWPVLIDDFVEY 246


>gi|36030883 RP42 homolog [Homo sapiens]
          Length = 259

 Score =  107 bits (267), Expect = 1e-23
 Identities = 57/175 (32%), Positives = 94/175 (53%), Gaps = 35/175 (20%)

Query: 111 YEYAGTDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQC 170
           Y+    ++ +G +G+++FC+D+ ++P ++ +L++AWK  A     F+ QE++ GMT L C
Sbjct: 72  YKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGC 131

Query: 171 DTTEKLRNTLDYLRSFLNDSTNFKLIYRYAFDFARQSKYK-------------VIN---- 213
           D+ EKL+  +  +   L +   FK  Y++ F+FA+    K             V+N    
Sbjct: 132 DSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFK 191

Query: 214 ------------------KDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEW 250
                             KD W  +L+FS  I  D+SNYDE+GAWPVL+D+FVE+
Sbjct: 192 FLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEF 246


>gi|27735047 DCN1, defective in cullin neddylation 1, domain
           containing 3 [Homo sapiens]
          Length = 304

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 60/202 (29%), Positives = 87/202 (43%), Gaps = 41/202 (20%)

Query: 95  KTEEEAFSSKRCLEWFYEYAGT-DDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNM 153
           K+  E  S +R  E F  Y    +D +  EGME+FC D+ V+P    +L+LAWK  A  M
Sbjct: 80  KSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATM 139

Query: 154 GYFTLQEWLKGMTSLQCDTTEKLRNTLDYLRSFLNDSTNFKLIYRYAFDFARQSK----- 208
             FT +E+  G  ++  D+ + +      L +       FK +YR+ F F   S+     
Sbjct: 140 CKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRS 199

Query: 209 -----------------------------------YKVINKDQWCNVLEFSRTINLDLSN 233
                                               K I++D W   L F++ I  DLSN
Sbjct: 200 LHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSN 259

Query: 234 YDEDGAWPVLLDEFVEWYKDKQ 255
           Y ED AWP L D FVEW  +++
Sbjct: 260 YSEDEAWPSLFDTFVEWEMERR 281


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 31.6 bits (70), Expect = 0.71
 Identities = 26/89 (29%), Positives = 32/89 (35%), Gaps = 8/89 (8%)

Query: 43  HQTGSLRSCSSSDCFNKVMPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFS 102
           H+  S  S S SD          KRR         KK      Y+K  S + + E    S
Sbjct: 206 HKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSS 265

Query: 103 SKRCLEWFYEYAGTD--------DVVGPE 123
           SK   E F E    D        D++GPE
Sbjct: 266 SKESQEEFLENPWKDRTKAEEPSDLIGPE 294


>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
           subunit [Homo sapiens]
          Length = 1977

 Score = 31.6 bits (70), Expect = 0.71
 Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 2/36 (5%)

Query: 33  NLTEDIGQDDHQTGSLRSCSSSDCFNKVMPPRKKRR 68
           ++TE  G +D + G+L SC+   C NK+M  R  RR
Sbjct: 477 SMTETQGDEDEEEGALASCTR--CLNKIMKTRVCRR 510


>gi|7427519 minichromosome maintenance complex component 6 [Homo
           sapiens]
          Length = 821

 Score = 31.2 bits (69), Expect = 0.93
 Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 7/98 (7%)

Query: 12  LNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDC-FNKVMPPRKKRRPA 70
           +N H  + A ++ I    N  N  EDI Q+     SLR   S  C  + ++    ++   
Sbjct: 683 INGHADSPAPVNGI----NGYN--EDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEE 736

Query: 71  SGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLE 108
             D+ + K+S   + Y K   + I +EEE  + KR +E
Sbjct: 737 EEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIE 774


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 31.2 bits (69), Expect = 0.93
 Identities = 19/48 (39%), Positives = 22/48 (45%)

Query: 49   RSCSSSDCFNKVMPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKT 96
            RS SSS       PPR +R P+      A+KSR     R   S R KT
Sbjct: 1708 RSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKT 1755


>gi|117320550 hypothetical protein LOC400566 [Homo sapiens]
          Length = 433

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 15/44 (34%), Positives = 23/44 (52%)

Query: 39  GQDDHQTGSLRSCSSSDCFNKVMPPRKKRRPASGDDLSAKKSRH 82
           G D HQ+ SL+S   S  F+ ++ P K+R P      S  + +H
Sbjct: 100 GDDKHQSQSLKSQPLSSSFHDILSPCKERGPKPEHRQSKVEKKH 143


>gi|215982794 myosin VA isoform 2 [Homo sapiens]
          Length = 1828

 Score = 29.3 bits (64), Expect = 3.5
 Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 137 ENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLR 184
           EN +M  L  K+D QN  Y  L E L  +  +    TEKLR+ L+ L+
Sbjct: 926 ENKIMQ-LQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972


>gi|215982791 myosin VA isoform 1 [Homo sapiens]
          Length = 1855

 Score = 29.3 bits (64), Expect = 3.5
 Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 137 ENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLR 184
           EN +M  L  K+D QN  Y  L E L  +  +    TEKLR+ L+ L+
Sbjct: 926 ENKIMQ-LQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score = 28.5 bits (62), Expect = 6.0
 Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 15/108 (13%)

Query: 16  LSTLANIHKIYHTLNKLNLTEDIG-----------QDDHQTGSLRSCS-SSDCFNKVMPP 63
           LST A +   +   + L+L E +            Q +H   +  +C  S D    ++ P
Sbjct: 121 LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP 180

Query: 64  RKKR--RPASGDDLSAKKSRHDSMYRKYDSTRIK-TEEEAFSSKRCLE 108
           R     RP  GD L ++++R+  +Y   D+   +    EA    R LE
Sbjct: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLE 228


>gi|115527120 nebulin [Homo sapiens]
          Length = 6669

 Score = 28.5 bits (62), Expect = 6.0
 Identities = 32/158 (20%), Positives = 62/158 (39%), Gaps = 24/158 (15%)

Query: 75   LSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVVGPEGMEKFCEDIGV 134
            + AK++  ++   +Y  T  KT+ +  + K  L+  Y    TDD+   +  E +   +G+
Sbjct: 5252 IRAKRAYWNASDLRYKETFQKTKGKYHTVKDALDIVYHRKVTDDISKIKYKENYMSQLGI 5311

Query: 135  ------EPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDT--------TEKLRNTL 180
                   PE+     +   +   ++ Y     WLKG+     DT         + L +  
Sbjct: 5312 WRSIPDRPEHFHHRAVTDTV--SDVKYKEDLTWLKGIGCYAYDTPDFTLAEKNKTLYSKY 5369

Query: 181  DYLRSFLNDSTNFKLI--------YRYAFDFARQSKYK 210
             Y   F    ++FK +        ++YA     + KY+
Sbjct: 5370 KYKEVFERTKSDFKYVADSPINRHFKYATQLMNEKKYR 5407


>gi|110630018 eukaryotic translation initiation factor 4 gamma, 2
           isoform 2 [Homo sapiens]
          Length = 869

 Score = 28.5 bits (62), Expect = 6.0
 Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 59  KVMPPRKKRRP--ASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLE 108
           K +P R  RR   ++ ++ + +K RHD+++RK      K   E F  K CLE
Sbjct: 49  KWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKF-DKLCLE 99


>gi|4503539 eukaryotic translation initiation factor 4 gamma, 2
           isoform 1 [Homo sapiens]
          Length = 907

 Score = 28.5 bits (62), Expect = 6.0
 Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 59  KVMPPRKKRRP--ASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLE 108
           K +P R  RR   ++ ++ + +K RHD+++RK      K   E F  K CLE
Sbjct: 49  KWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKF-DKLCLE 99


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,537,220
Number of Sequences: 37866
Number of extensions: 399458
Number of successful extensions: 1317
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1299
Number of HSP's gapped (non-prelim): 23
length of query: 257
length of database: 18,247,518
effective HSP length: 100
effective length of query: 157
effective length of database: 14,460,918
effective search space: 2270364126
effective search space used: 2270364126
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.