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Search of human proteins with 92091575
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
(915 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|92091575 coiled-coil domain containing 57 [Homo sapiens] 1769 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 107 4e-23
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 107 5e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 102 1e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 102 2e-21
gi|148746195 trichohyalin [Homo sapiens] 101 3e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 100 6e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 100 6e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 100 6e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 100 6e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 100 1e-20
gi|156104908 myosin heavy chain 6 [Homo sapiens] 98 3e-20
gi|110611218 ribosome binding protein 1 [Homo sapiens] 98 4e-20
gi|110611220 ribosome binding protein 1 [Homo sapiens] 98 4e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 97 7e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 95 3e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 94 4e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 94 8e-19
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 94 8e-19
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 92 2e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 92 2e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 92 2e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 92 2e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 92 2e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 92 2e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 92 2e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 92 2e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 92 2e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 92 2e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 92 3e-18
>gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
Length = 915
Score = 1769 bits (4583), Expect = 0.0
Identities = 915/915 (100%), Positives = 915/915 (100%)
Query: 1 MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN 60
MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN
Sbjct: 1 MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN 60
Query: 61 LQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ 120
LQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ
Sbjct: 61 LQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ 120
Query: 121 QLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFES 180
QLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFES
Sbjct: 121 QLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFES 180
Query: 181 KMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELER 240
KMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELER
Sbjct: 181 KMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELER 240
Query: 241 KLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLV 300
KLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLV
Sbjct: 241 KLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLV 300
Query: 301 AVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVK 360
AVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVK
Sbjct: 301 AVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVK 360
Query: 361 SAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLE 420
SAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLE
Sbjct: 361 SAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLE 420
Query: 421 RDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAV 480
RDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAV
Sbjct: 421 RDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAV 480
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRK 540
TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRK
Sbjct: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRK 540
Query: 541 EMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHL 600
EMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHL
Sbjct: 541 EMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHL 600
Query: 601 EDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLAL 660
EDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLAL
Sbjct: 601 EDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLAL 660
Query: 661 RKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHL 720
RKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHL
Sbjct: 661 RKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHL 720
Query: 721 RIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQG 780
RIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQG
Sbjct: 721 RIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQG 780
Query: 781 PKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLG 840
PKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLG
Sbjct: 781 PKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLG 840
Query: 841 SSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAK 900
SSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAK
Sbjct: 841 SSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAK 900
Query: 901 GCQRPPKIRNYNIMD 915
GCQRPPKIRNYNIMD
Sbjct: 901 GCQRPPKIRNYNIMD 915
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 107 bits (268), Expect = 4e-23
Identities = 131/618 (21%), Positives = 279/618 (45%), Gaps = 60/618 (9%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQ--EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL 64
E N L ++EEE A + Q+ ++ L DT+ ++++ G + L+E L+
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 65 EERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQA---LAREARKVEELQQQQQ 121
E LE A+ + + + + E+ +L ++ RQ L ++ +K ++L +++
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461
Query: 122 LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEE-LDGELALQRQ-------- 172
+ E +R ++ + E +L R LEE L+ + +RQ
Sbjct: 1462 SISARYAEERDRAEAE--------AREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 173 ELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAE 232
E L+ + + K HE + +++ L EL+A ++A + ++Q
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ--- 1570
Query: 233 ATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ-------LTRKKEEETFKRKH 285
A A+ ER LQ+R + ++ + + +V++LE +L + ++KK E K
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE 1630
Query: 286 EELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEK 345
+++ + +D V+ ++ Q+++ Q + E +A + + AQ + +E + K
Sbjct: 1631 AQIEAANKARDEVIKQLRKLQA-QMKDYQRELEEARASRDEIFAQSKESEKK----LKSL 1685
Query: 346 DAAIDQLREDASTVKSA---WDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDI 402
+A I QL+E+ ++ + A + + +L+ E+ + L +E+ +L+A++A+ ++++
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 403 ERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAK 462
E + + L +R R + L +D ER QKS+ Q L ++ AK
Sbjct: 1746 EEEQSNMELLNDRFR-----KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800
Query: 463 LQETEQALQEQ-EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEI 521
LQE E A++ + + + A+ + Q + L R A L+R+ E+++ + F E
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860
Query: 522 QR-----LREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATP 576
+R +EQ + Q+++++E + A +A++ + D AT
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEE--------ATRANASRRKLQRELDDAT- 1911
Query: 577 DYVLALEAEIRTLKHKFK 594
+ L E+ TLK++ +
Sbjct: 1912 EANEGLSREVSTLKNRLR 1929
Score = 100 bits (250), Expect = 5e-21
Identities = 148/651 (22%), Positives = 281/651 (43%), Gaps = 89/651 (13%)
Query: 13 LLLRKEEEWRA-------LQAHRTQLQEAALQDTRSQLEEAQGKLRC-LQEDFVYNLQVL 64
L LR + WR LQ R + + A + +++E Q K+ L+E + Q+L
Sbjct: 827 LKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLL 886
Query: 65 EERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAF 124
EE+++ E+ A +EL EA ++R LA + +++EE+ L
Sbjct: 887 EEKNILAEQLQAE---------------TELFAEAEEMRARLAAKKQELEEI-----LHD 926
Query: 125 QEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLE---FESK 181
E R+E E ++N + + +++ + LE +L+E +G RQ+L LE E+K
Sbjct: 927 LESRVEEEE---ERNQILQNEKKKMQAHIQDLEEQLDEEEGA----RQKLQLEKVTAEAK 979
Query: 182 MRKREHEFRLQADNMSNTALSREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAEL 238
++K E E L D S ++L ++ +L +E A+ + E ++L
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 239 ERKLQSRAGELQDLEAMSR---ARVKDLEDKLHSVQLTRKKEEETFKRKHEELD-RLARE 294
E +L+ Q+LE R DL+D++ +Q + + +K EEL LAR
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 295 KDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRE 354
D L K ++ ++ELQ ++ ELQ E+ +A +AE ++ D ++E +A +L +
Sbjct: 1100 DDETLH--KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157
Query: 355 DAST------VKSAWDAQIAQLSK----EMVSRDLQIQTLQEEEVKLKAQVARSQQDIER 404
T +++ + ++A+L K E + + QIQ +++ +++ + +R
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217
Query: 405 YKQQLSLAVERERSLERDQVQLGLD----WQRRCDDIER-----DQIQKSEALIQGLSMA 455
+K L + ++ LE D +L + Q + + + Q+Q+ A +
Sbjct: 1218 FKANLE---KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 456 KSQVAAKLQETEQALQE-----QEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEE 510
+ ++A K + + L +E K + +D A ++ Q LL+ EE
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ-----DTQELLQ--EE 1327
Query: 511 EISKDFPSSEIQRLREQNTSLR-------NAIAQMRKEMEALSHQIPPPIQTAAESTDAN 563
K SS I++L E+ SL+ A + K++ AL Q+ + +
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 564 QPDPEAGGDAATPDYVLALEAEIRTLKH-KFKTLEKHLEDVLDPLKMSSPH 613
+ EA L+ E + L + K + + L+ LD L + H
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Score = 100 bits (248), Expect = 8e-21
Identities = 156/649 (24%), Positives = 277/649 (42%), Gaps = 72/649 (11%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFV---YNLQVLEERD 68
E + +EEE + + + +A +QD QL+E +G + LQ + V ++ +EE
Sbjct: 928 ESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI 987
Query: 69 LELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL--QQQQQLAFQE 126
L LE ++ F + ++ E R AE S E + + LA+ K E + +++L +E
Sbjct: 988 LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 127 H-RLELERVHSDKNGE-------IDHHREQYENLKWTLERKLEELDGELALQRQELLLEF 178
R ELE+ +GE I + Q + LK L +K EEL G LA E L +
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 179 ESKMRKREHEFR---LQADNMSNTAL--SRELKVKLLHKELEALK-------EAGAKAAE 226
+ RE + + LQ D S A E + + L +ELEALK + A E
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 227 SLQRAEATNAELERKLQ----SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFK 282
+ E AEL++ L+ + ++QD+ +++L ++L + + E+ +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 283 RKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTA 342
+ LA E VL VK + ++L +V EL H + E R E
Sbjct: 1228 GLETDNKELACEV-KVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRVE------L 1278
Query: 343 KEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQE---EEVKLKAQVARSQ 399
EK + + ++ ST+ + + + +K+ S + Q+Q QE EE + K ++
Sbjct: 1279 AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI 1338
Query: 400 QDIERYKQQLSLAVERE----RSLERDQVQLG---LDWQRRCDD----------IERDQI 442
+ +E K L E E ++LE+ + L D +++ DD ++ +
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 443 QKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQ 502
+ +EAL Q L K+ KL++T+ LQ++ L +T++ D Q +
Sbjct: 1399 KDAEALSQRLE-EKALAYDKLEKTKNRLQQE---LDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 503 MLLRQHEEEISKDFPSSEIQ---RLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAES 559
LL + E+ IS + + RE+ T + + + +EA Q A+
Sbjct: 1455 QLLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
D + G + V LE R L+ + + + LE++ D L+
Sbjct: 1514 EDLMSSKDDVGKN------VHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 107 bits (267), Expect = 5e-23
Identities = 161/702 (22%), Positives = 298/702 (42%), Gaps = 129/702 (18%)
Query: 18 EEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER---- 73
EE L + QL E +++ +LE+ + + D + LE+ EL++
Sbjct: 951 EERCHLLIKSKVQL-EGKVKELSERLEDEEE----VNADLAARRRKLEDECTELKKDIDD 1005
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
A+A + ++A +V L E A L +++AR ++ + LQ+ Q A + + E +R
Sbjct: 1006 LKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDR 1065
Query: 134 VHS---------DKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELL------LEF 178
V + + +++ EQ + L+ ER +L+G+L L ++ + +
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL 1125
Query: 179 ESKMRKREHE-----FRLQADNMSNTALSRELK-----VKLLHKELEALKEAGAKAAESL 228
E K++K++ E R++ + + + +++K + L +ELEA E A+A
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA--ERAARARVEK 1183
Query: 229 QRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEEL 288
QRAEA ELE +L R E A R + E +L +L R+ EE +HE
Sbjct: 1184 QRAEAAR-ELE-ELSERLEEAGGASAGQREGCRKREAELG--RLRRELEEAAL--RHEAT 1237
Query: 289 DRLAREKDAVLVAVKGAHVEQLQ-----------ELQTRVLELQAHCETL------EAQL 331
R K A A G V+ LQ EL+ V +L A+ ETL +L
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL 1297
Query: 332 RRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQ------ 385
R Q AK K + + DAST + + +LS+ + ++ I L
Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALA 1357
Query: 386 -----------EEEVKLKAQVARSQQDI--------ERYKQQLSLAVERERSLERDQVQL 426
EEE K K+ +A + Q + E+++++ E +R L + ++
Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEV 1417
Query: 427 GLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQ 486
W+ + E D IQ++E L + AK ++A +LQE E+ ++ K +LE+
Sbjct: 1418 A-QWRSK---YEADAIQRTEELEE----AKKKLALRLQEAEEGVEAANA--KCSSLEK-- 1465
Query: 487 AVQALRMHGLPRPGAQMLLRQHEEEISKDF--PSSEIQRLREQNTSLRNAIAQMRKEMEA 544
A++ L+ E+++ + +S L ++ L A+ + R++ E
Sbjct: 1466 --------------AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1511
Query: 545 LSHQIPPPIQTAAESTDANQPDPEAGGD---AATPDYVLALEAEIRTLKHKFKTLEKHLE 601
+ ++ +A Q + G + ALEA + TLK + K L++ +
Sbjct: 1512 MQREL-----------EAAQRESRGLGTELFRLRHGHEEALEA-LETLKRENKNLQEEIS 1559
Query: 602 DVLDPLKMSSPHAESQPSVRTSTETTGGSAQAG--QAGGSVQ 641
D+ D + +S + + + E QA +A G+++
Sbjct: 1560 DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Score = 91.7 bits (226), Expect = 3e-18
Identities = 145/631 (22%), Positives = 258/631 (40%), Gaps = 117/631 (18%)
Query: 18 EEEWRALQAHRTQLQEA--ALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYD 75
EEE AL+A L+ A A + R +LEE + + D LQ ++ + E
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 76 AAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVH 135
+++ E + E+SE + ++ LA RK+E+ + + + +L L +
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEELDGELA-LQRQELLLEFESKMRKREHEFRL--- 191
+K E K++ L E+A L L E K + H+ L
Sbjct: 1015 KEKQAT---------------ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL 1059
Query: 192 QADNMSNTALSR-ELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQ 250
QA+ +AL++ +L+++ ++LE E K +RA+ RKL+
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAK-------RKLEG------ 1106
Query: 251 DLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLA-REKDAVLVAVKGAHVEQ 309
DL+ + +DK ++ EE K+K EL +L+ R +D L+ GA +++
Sbjct: 1107 DLKLTQESVADAAQDK--------QQLEEKLKKKDSELSQLSLRVEDEQLL---GAQMQK 1155
Query: 310 -LQELQTRVLELQAHCETLEAQLRRAEWRQADTAKE------------------------ 344
++ELQ R EL+ E A R E ++A+ A+E
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 345 KDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQI-----------QTLQEEEVKLKA 393
++A + +LR + +A +A L ++ ++ Q L++E+ +L+
Sbjct: 1216 REAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRM 1275
Query: 394 QV--------------ARSQQDIERYKQQLSLAVERERSLERDQVQLGLD---WQRRCDD 436
+V A +++ Y+ QLS A + L+R Q +
Sbjct: 1276 EVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGE 1335
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGL 496
+ R +++ E LI LS K+ A L+E + L+E+ A+ AVQAL
Sbjct: 1336 LSR-LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALA----HAVQAL----- 1385
Query: 497 PRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTA 556
R +L QHEEE +E+QRL + + +AQ R + EA + Q ++ A
Sbjct: 1386 -RHDCDLLREQHEEEAE---AQAELQRLLSKANA---EVAQWRSKYEADAIQRTEELEEA 1438
Query: 557 AESTDANQPDPEAGGDAATPDYVLALEAEIR 587
+ + E G +AA +A++R
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Score = 85.5 bits (210), Expect = 2e-16
Identities = 135/621 (21%), Positives = 255/621 (41%), Gaps = 74/621 (11%)
Query: 25 QAHRTQLQEAAL--QDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDL---ELERYDAAFA 79
+ + QL EA + ++ + QL +A + LQ + ++LEE++ +L R A A
Sbjct: 1299 RTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAA 1358
Query: 80 QAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKN 139
Q+ E + E S+ K A QAL + + E +++ E + EL+R+ S N
Sbjct: 1359 QSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEA----EAQAELQRLLSKAN 1414
Query: 140 GEIDHHREQYENLKWTLERKLEELDGELALQRQEL-------------LLEFESKMRKRE 186
E+ R +YE +LEE +LAL+ QE L + + +++
Sbjct: 1415 AEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTES 1474
Query: 187 HEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKL-QSR 245
+ L+ + ++ A + + K + L + LE + + L+ A+ + L +L + R
Sbjct: 1475 EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLR 1534
Query: 246 AGELQDLEAMSRAR------VKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVL 299
G + LEA+ + +++ D V L+ K +E K K + L+ E A L
Sbjct: 1535 HGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTK-KALEGEKSEIQAAL 1593
Query: 300 VAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
+GA L+ +T+ L +Q ++A++ R EKD LR +
Sbjct: 1594 EEAEGA----LELEETKTLRIQLELSQVKAEVDR-------KLAEKDEECANLRRN---- 1638
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQT-LQEEEVKLKAQVARSQQDIERYKQQLSLAVERERS 418
Q + E + L +T + E ++LK ++ D+E L L ++
Sbjct: 1639 --------HQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE-----LQLGHATRQA 1685
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALI----QGLSMAKSQVAAKLQETEQALQEQE 474
E + Q + + RD+ Q+ A + Q L S +AA+L+E AL++ E
Sbjct: 1686 TEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGE 1745
Query: 475 VVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSE--IQRLREQNTSLR 532
+ E +A + L + G ++ E ++++ E Q RE +
Sbjct: 1746 RSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAK 1805
Query: 533 NAIA-------QMRKEMEALSH--QIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALE 583
AI +++KE + +H ++ ++ A + E V LE
Sbjct: 1806 KAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLE 1865
Query: 584 AEIRTLKHKFKTLEKHLEDVL 604
A++R L+ + +K + L
Sbjct: 1866 AKVRELEAELDAEQKKHAEAL 1886
Score = 85.1 bits (209), Expect = 3e-16
Identities = 181/795 (22%), Positives = 311/795 (39%), Gaps = 72/795 (9%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQE--AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEER 67
L++L LR E+E + +++E A ++ +LE + +++ + LEE
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEEL 1195
Query: 68 DLELERYDAAFAQAREWEEARRAEVSELK--IEAAKLRQ-----ALAR-EARKVEELQQQ 119
LE A A RE R AE+ L+ +E A LR AL R +A EL +Q
Sbjct: 1196 SERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQ 1255
Query: 120 QQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWT------LERKLEELDGELALQRQE 173
+ Q R +LE+ S+ E+D E L L R E+ E ++ +E
Sbjct: 1256 VD-SLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 174 LLLEFESKMRKREHEFRLQADNMSNTALSRELKVK-LLHKELEALKEAGAKAAESLQRAE 232
L + +R RLQ + + LSR L+ K L +L K A++ E L+R
Sbjct: 1315 LQRQLADASTQRG---RLQTE---SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQL 1368
Query: 233 ATNAELERKLQSRAGELQ-DLEAMSRARVKDLEDKLHSVQLTRKKEEETFK-RKHEELDR 290
++ + L L+ D + + ++ E + +L K E + R E D
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA 1428
Query: 291 LAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAID 350
+ R ++ L K +LQE + V A C +LE R + D E
Sbjct: 1429 IQRTEE--LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLE------ 1480
Query: 351 QLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLS 410
E A++ +A D + L + + R Q + +Q E + + ++ R +
Sbjct: 1481 --LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538
Query: 411 LAVERERSLERDQVQLGLDWQRRCDDIERD--QIQKSEALIQGLSMAKSQVAAKLQETEQ 468
A+E +L+R+ L + D + IQ+ E + L KS++ A L+E E
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 469 ALQEQEVVLKAVTLERDQA-VQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQ 527
AL+ +E + LE Q + R L R H+ + +Q +
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAV------ESLQASLDA 1652
Query: 528 NTSLRNAIAQMRKEMEA----LSHQIPPPIQTAAESTDAN-----QPDPEAGGDAATPDY 578
T RN +++K+ME L Q+ + A E+ A Q E G
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 1712
Query: 579 VLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGG 638
L + + L+ + L LE++ L+ + + S R + + +A +
Sbjct: 1713 AAELHEQAQALERRASLLAAELEELRAALE------QGERSRRLAEQEL---LEATERLN 1763
Query: 639 SVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPRE 698
+ + G Q + + LA +L V+ +K + + A + EL +E
Sbjct: 1764 LLHSQNTGLLNQKKKLEADLA--QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821
Query: 699 VD-QVHLEVLE--LRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGRE---DAKSA 752
D HLE ++ L + V EL L A+ A G+KQ +A E DA+
Sbjct: 1822 QDTSAHLERMKKTLEQTVRELQARLEEAEQ-AALRGGKKQVQKLEAKVRELEAELDAEQK 1880
Query: 753 EDEAPSRHLGKHQPR 767
+ + + KH+ R
Sbjct: 1881 KHAEALKGVRKHERR 1895
Score = 62.0 bits (149), Expect = 2e-09
Identities = 110/497 (22%), Positives = 197/497 (39%), Gaps = 98/497 (19%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL--EERDL 69
+L L+ E E L+ R AAL + LE A + R +E+ L+ E R L
Sbjct: 1467 KLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL 1526
Query: 70 --ELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ------- 120
EL R +A E E + E L+ E + L ++ + ++EL++ +
Sbjct: 1527 GTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586
Query: 121 ---QLAFQEH--------------RLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL 163
Q A +E +LEL +V ++ + ++ E+ NL+ +R +E L
Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESL 1646
Query: 164 DGELALQRQEL--LLEFESKMRKREHEFRLQADNMSNTALSRELKVKL------------ 209
L + + L + KM ++ LQ + + A + +L
Sbjct: 1647 QASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGR 1706
Query: 210 ---------LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARV 260
LH++ +AL+ + A L+ A + ER R E + LEA R +
Sbjct: 1707 DEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERS--RRLAEQELLEATERLNL 1764
Query: 261 ------------KDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK----- 303
K LE L QL+ + EE +R+ E DA ++A +
Sbjct: 1765 LHSQNTGLLNQKKKLEADL--AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1822
Query: 304 --GAHVEQLQE-LQTRVLELQAHCET---------------LEAQLRRAEWRQADTAKEK 345
AH+E++++ L+ V ELQA E LEA++R E K+
Sbjct: 1823 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 1882
Query: 346 DAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERY 405
A+ +R+ VK A A+ ++ ++R +Q+ KL+++V ++ E
Sbjct: 1883 AEALKGVRKHERRVKEL--AYQAEEDRKNLAR------MQDLVDKLQSKVKSYKRQFEEA 1934
Query: 406 KQQLSLAVERERSLERD 422
+QQ + + + R + +
Sbjct: 1935 EQQANTNLAKYRKAQHE 1951
Score = 58.5 bits (140), Expect = 3e-08
Identities = 79/354 (22%), Positives = 152/354 (42%), Gaps = 48/354 (13%)
Query: 206 KVKLLHKELEALKEAGAKAAE------SLQRAEATNAELERKLQSRAGELQDLEAMSRAR 259
K+K L + +A +E A AE +L AEA ELE S E DL +A
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 260 VKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLE 319
+L D L K + + + E +RL E++ V + ++L+ E
Sbjct: 944 QDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEE-----VNADLAARRRKLEDECTE 998
Query: 320 LQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKE----MV 375
L+ + L+ L +AE KEK A ++++ + + +A D +A+L+KE
Sbjct: 999 LKKDIDDLKLTLAKAE-------KEKQATENKVK-NLTEEMAALDESVARLTKEKKALQE 1050
Query: 376 SRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCD 435
+ + LQ EE ++ A + +++ +E+ + L ++E+E+ L +D +R
Sbjct: 1051 AHQQALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLR-------MDTERAKR 1102
Query: 436 DIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG 495
+E D ++ ++ + + K Q+ KL++ + L + +LR+
Sbjct: 1103 KLEGD-LKLTQESVADAAQDKQQLEEKLKKKDSELSQ----------------LSLRVED 1145
Query: 496 LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549
GAQM + E + + E++ R + A+ +E+E LS ++
Sbjct: 1146 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERL 1199
Score = 39.7 bits (91), Expect = 0.013
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 18/141 (12%)
Query: 18 EEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAA 77
E+ R LQA + ++AAL+ + Q+++ + K+R L+ E D E +++ A
Sbjct: 1836 EQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE----------AELDAEQKKHAEA 1885
Query: 78 FAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSD 137
R+ E V EL +A + R+ LAR V++LQ + + ++ + E
Sbjct: 1886 LKGVRKHER----RVKELAYQAEEDRKNLARMQDLVDKLQSK----VKSYKRQFEEAEQQ 1937
Query: 138 KNGEIDHHREQYENLKWTLER 158
N + +R+ L ER
Sbjct: 1938 ANTNLAKYRKAQHELDDAEER 1958
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 102 bits (255), Expect = 1e-21
Identities = 175/782 (22%), Positives = 324/782 (41%), Gaps = 120/782 (15%)
Query: 12 ELLLRKEEEWRALQAHRTQL------QEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE 65
ELL +++ E A A Q E L+ + L A KL L E + L
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLN 616
Query: 66 ERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQ 125
++ L+LE + + E E R + EA K R+AL + +E Q+ + A
Sbjct: 617 QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676
Query: 126 EHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESK---- 181
E + +L + +K EI + + + +LE+L E Q + L + K
Sbjct: 677 ELQADLRDIQEEKE-EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Query: 182 MRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK 241
K E RLQA L+ +L+ KEL L+ + +A + E T +LE +
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 242 LQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVA 301
+Q+ + + + + V+ L+ +L + + ++E + R +L + +E L
Sbjct: 794 IQT----VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR---QLAQAEQEGKTALEQ 846
Query: 302 VKGAHVEQLQELQTR--------VLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLR 353
K AH +++ +L+ + EL E+LE + E R + E +A Q
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE 906
Query: 354 EDASTVKSAWDAQIAQLSKEMVS-----------------------RDLQIQTLQEEEVK 390
E+ + +SA + KE VS +D+++Q L+E+E
Sbjct: 907 EERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966
Query: 391 --LKAQVARSQQDIE----RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQK 444
L+ Q+ +Q++++ +++ L+ E SL +D+ +D Q++ +D++ + +
Sbjct: 967 GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK----MDLQKQVEDLKSQLVAQ 1022
Query: 445 SEALIQGLSMAKSQVAAKLQETEQ-----------------ALQEQE---VVLKAVTLER 484
++ + + +V KL+ET++ +L E+E +VL+ R
Sbjct: 1023 DDS----QRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 485 DQAVQALRMHGLPRPGAQM-------LLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ 537
Q + ALR G Q LLRQ +E DF + E Q L E S Q
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS-HITEQQ 1137
Query: 538 MRKEM---EALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFK 594
+R + EA + Q+ +++ +A + + G A +A++ +L +
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA-------QAQLASL---YS 1187
Query: 595 TLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPV 654
L++ L V + S +S PSV G+ + G + A + A V
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA------LSAEAV 1241
Query: 655 SSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQ-RELPREVDQVHLEVLELRKQV 713
+S AL KL +L T+ + VLR+ ++ + + E QVH E+ +L++Q+
Sbjct: 1242 AS--ALHKLHQ-----DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 714 AE 715
++
Sbjct: 1295 SQ 1296
Score = 87.0 bits (214), Expect = 7e-17
Identities = 188/806 (23%), Positives = 330/806 (40%), Gaps = 116/806 (14%)
Query: 35 ALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVSE 94
A+QD R QL Q + LQ+ EE L + R+ + ++
Sbjct: 401 AVQDLRQQLAGCQEAVNLLQQQH----DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Query: 95 LKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKW 154
++++ + L ++AR EEL+QQ ++ QE L RV+ + + D + Q E +
Sbjct: 457 -EVDSLSKERELLQKAR--EELRQQLEVLEQE-AWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 155 TLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKEL 214
L + E + + QE+L+ E+K Q++++S RE ++ H E
Sbjct: 513 ELHLAVRERE-----RLQEMLMGLEAK----------QSESLSELITLREA-LESSHLEG 556
Query: 215 EALKEAGAKAAESLQRAEATNAEL---ERKLQSRAGELQ----DLEAMSRARVKD----- 262
E L++ + +L RAE + AEL E L++ +L+ L A++ A D
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLN 616
Query: 263 -----LEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVE-QLQELQTR 316
LE++ SV + E+ R ++D EK + K H+E QLQ+ +
Sbjct: 617 QQLLQLEEENQSVCSRMEAAEQA--RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 317 VLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVS 376
ELQA ++ + + + +++ +++AA QL + K Q L++ +
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK----RQEEVLARAVQE 730
Query: 377 RDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVE-RERSLERDQVQLGLDWQRRCD 435
++ ++ EV+L+A V R +QD+ Q LS A E E SL Q Q
Sbjct: 731 KEALVREKAALEVRLQA-VERDRQDLAEQLQGLSSAKELLESSLFEAQ------QQNSVI 783
Query: 436 DIERDQIQKSEALIQGLSMAKSQVAAKLQ------ETEQALQEQEVVLKAVTLERDQAVQ 489
++ + Q+ E IQ ++ AK + +++ +TE++ EQ ERD A +
Sbjct: 784 EVTKGQL---EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ---------ERDAAAR 831
Query: 490 ALRMHGLPRPGAQMLLRQ---HEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALS 546
L + G L +Q HE+E+++ E +R Q L A+ + +E L
Sbjct: 832 QLAQ--AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ-ELAKALESLEREKMELE 888
Query: 547 HQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDP 606
++ QT E+ A + + ++A L E E +L +K L D
Sbjct: 889 MRLKEQ-QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 607 LKMSSPHAESQPSVRTSTETTG---GSAQAGQAGGSVQAGQAGGSVQA-GPVSSGLALRK 662
L+ + Q ETTG Q Q A Q + A SS L K
Sbjct: 948 LERLRQDMKVQK--LKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 663 LGDRVQLLNL------------LVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELR 710
+ + Q+ +L LV + Q+ LRE E +Q+EL RE + L ++E
Sbjct: 1006 MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKE 1065
Query: 711 KQVAELGKHLRIAQ------HGGAEPSGRKQPPASDAVALGREDAKSAE----------- 753
+++ L + I Q + + +Q S + L R++ K E
Sbjct: 1066 QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL 1125
Query: 754 DEAPSRHLGKHQPRSAQVGSRLDALQ 779
+E + H+ + Q R++ A Q
Sbjct: 1126 EELEASHITEQQLRASLWAQEAKAAQ 1151
Score = 87.0 bits (214), Expect = 7e-17
Identities = 143/647 (22%), Positives = 259/647 (40%), Gaps = 92/647 (14%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL-----EERDL 69
L K ++ R + + Q E L DT ++ + +L+ LQ N + ++ L
Sbjct: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 70 ELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALARE--ARKVEELQ--------QQ 119
E E + A RRAE+ ++ + + A+E +VE LQ Q
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
Query: 120 QQLAFQEHRLELERVHSD-KNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEF 178
E L R KN E++ RE+ + L+ E K+ + G+ + LL +
Sbjct: 1372 SAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ--GKALQENLALLTQT 1429
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAEL 238
++ + R Q + ++ ++LL +L+ + E +Q E + L
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 239 ERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAV 298
E L E + + R ++++LE K+ ET + E +KD +
Sbjct: 1490 EH-LPMAVQEREQKLTVQREQIRELE-----------KDRETQRNVLEHQLLELEKKDQM 1537
Query: 299 LVAVKGAHVE---QLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRED 355
+ + +G + QL L+ LEL+ + +E Q + + + ++ A+ L D
Sbjct: 1538 IESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR-VALTHLTLD 1596
Query: 356 ASTVKSAWDAQIAQ----------LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERY 405
AQ +Q L++E+ RD ++++ +E+ +L+ Q QD+ER
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 406 KQQLSLAVER-----------ERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
Q+L L ER + LE D Q+ L + R ++ + E +G
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 455 AKSQ------VAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQ--MLLR 506
+K+Q + L++ E+ ++ Q+ + + +DQ Q L+ GL R + +LL
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ--GLHRKVGETSLLLS 1774
Query: 507 QHEEEI---------SKDFPSSEIQRLREQNTSLRNAIAQMRKEMEAL---SHQIPPPIQ 554
Q E+EI +++ + Q L+ Q + A+AQ +E+EAL Q +
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 555 TAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLE 601
E DA Q ALE TLK + L+ H E
Sbjct: 1835 RVKEKADALQG---------------ALEQAHMTLKERHGELQDHKE 1866
Score = 83.2 bits (204), Expect = 1e-15
Identities = 133/645 (20%), Positives = 265/645 (41%), Gaps = 95/645 (14%)
Query: 13 LLLRKEEEWRALQAHRTQLQEAALQ------DTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
LL ++E+E LQ QLQEA Q +SQL+EAQ + L +
Sbjct: 1772 LLSQREQEIVVLQQ---QLQEAREQGELKEQSLQSQLDEAQ--------------RALAQ 1814
Query: 67 RDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQE 126
RD ELE QA+ EE + + L+ + L ++++ ++Q + +E
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE 1874
Query: 127 HRLELERVHS--DKNGEIDHHREQYENLKWTLERKLEELDGELALQR---QELLLEFESK 181
+E RV + + G++ + E L+++ E E ++ Q+ L+ ++
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 182 MRKREHEFR-LQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAE---ATNAE 237
+++R+ E L+A++ S+ + + EAL+EA KA +LQ E AE
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARAR-----AEALQEALGKAHAALQGKEQHLLEQAE 1989
Query: 238 LERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA 297
L R L++ LQ +A + LE+ L + + ++ ++ ++L + ++D
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 298 VLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDAS 357
L H ++ ++L + L + ++ + + R+ +E+ + Q +
Sbjct: 2050 EL-----RHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE----EEEIRGLHQSVRELQ 2100
Query: 358 TVKSAWDAQIAQLSKEMVSRDLQ-------IQTLQEEEVKLKAQVARSQQDIERYKQQLS 410
+ + +I +L + +L+ ++E+ +KL + R Q+++ER + L
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR 2160
Query: 411 LAVERERSLERDQVQLGLDWQRRCDDIERD--QIQKSEALIQGLSMAKSQVAAKLQETEQ 468
RE ++W+ + D+ Q + S + +Q ++M + +Q
Sbjct: 2161 QTEARE-----------IEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQ 2209
Query: 469 ALQEQ-EVVLKAVTLER----------------DQAVQALRMHGL---PRPGA--QMLLR 506
LQ++ E+ +A+ ER +Q VQ + G+ P P + R
Sbjct: 2210 RLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269
Query: 507 QHEEEISKDFPSSEI--QRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAA---ESTD 561
Q E + + EI RL+ N LR+ + Q+ +E L + Q +
Sbjct: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKAT 2329
Query: 562 ANQPDPEAGGDAATPD--YVLALEAEIRTLKHKFKTLEKHLEDVL 604
A+ P + G D V L+ E+ L+ + K +D +
Sbjct: 2330 ASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYI 2374
Score = 82.8 bits (203), Expect = 1e-15
Identities = 187/850 (22%), Positives = 341/850 (40%), Gaps = 140/850 (16%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L+ KE+ LQ +++ L R ++EAQG+ + L Q ++E++ +
Sbjct: 1061 LMEKEQRLLVLQ-EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 74 YDAAFAQARE----WEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQ-EHR 128
+A + E E+ RA + + +AA+L+ L ++E L +QQ Q + +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
Query: 129 LELERVHSDKNGEIDHHREQYENLK---------WTLERKLEELDGELALQRQELLLEFE 179
+L ++S + E L W LE + +G +L ++ LL
Sbjct: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE---PDQNGARSLFKRGPLL--- 1233
Query: 180 SKMRKREHEFRLQADNMSNTALSRELKVKLLHK----------ELEALKEAGAKAAESLQ 229
TALS E LHK + L++ K E L
Sbjct: 1234 -------------------TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLT 1274
Query: 230 RAEATNAELERKLQSRAGEL---QDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHE 286
EA +++ +LQ +L Q+ ++ + LE +L + T + +R
Sbjct: 1275 DTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR--A 1332
Query: 287 ELDRL-AREKDAVLVAVKGAHVEQLQELQTRVLELQAHCET---LEAQLRRAEWRQADTA 342
EL R+ A+ + +L A K Q++ LQ V+E +A LE LR A
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR----SAL 1388
Query: 343 KEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDI 402
K K+ ++ RE A ++ + ++A Q + LQE L +A ++++
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVA-----------QGKALQENLALLTQTLAEREEEV 1437
Query: 403 ERYKQQLSLAVERERSLERDQVQ-LGLDWQRRCD--DIERDQIQ---KSEALIQGLSMAK 456
E + Q+ +E++R +++ ++ L LD ++R D++++QIQ K ++++ L MA
Sbjct: 1438 ETLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 457 SQVAAKL-------QETEQALQEQEVVLKAVTLE---RDQAVQALR--MHGLPRPGAQ-- 502
+ KL +E E+ + Q VL+ LE +DQ +++ R + L +
Sbjct: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Query: 503 -MLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM-------RKEMEALSHQI----- 549
+ L E + I+ L Q + R A+ + +E++A S QI
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 550 ------------PPPIQTAAESTDANQPDPE-AGGDAATPDYVLALEAE-IRTLKHKFKT 595
+++ E + Q E D D L L+ E I+ L+ +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
Query: 596 LEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVS 655
K LE+ L+ +K+S E + T + A+ G+ Q G
Sbjct: 1677 QTKILEEDLEQIKLSL--RERGRELTTQRQLMQERAEEGKGPSKAQRGSL--------EH 1726
Query: 656 SGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAE 715
L LR V+ + L++ L++ LE + L R+V + L + + +++
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQE--LKDQLEQQL--QGLHRKVGETSLLLSQREQEIVV 1782
Query: 716 LGKHLRIAQHGGAEPSGRKQPPASDAV-ALGREDAKSAEDEAPSRHLGKHQPRSAQVGSR 774
L + L+ A+ G Q +A AL + D E EA + + Q + +V +
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD---QELEALQQEQQQAQGQEERVKEK 1839
Query: 775 LDALQGPKTQ 784
DALQG Q
Sbjct: 1840 ADALQGALEQ 1849
Score = 82.8 bits (203), Expect = 1e-15
Identities = 134/558 (24%), Positives = 226/558 (40%), Gaps = 95/558 (17%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
E L +L E+ +AL A + Q E Q +E + + R LQ+ ++ VL+E
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAE--------QAQEHEVETRALQDSWLQAQAVLKE 1937
Query: 67 RDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQAL-AREARKVEELQQQQQL--- 122
RD ELE A +R EEA RA L+ K AL +E +E+ + + L
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997
Query: 123 ---------AFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQ- 172
A Q H +LE + GEI +Y+ L++ L + D EL Q++
Sbjct: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER 2057
Query: 173 ELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAE 232
E LLE R +E+ + + N+ E +++ LH +S++ +
Sbjct: 2058 EQLLEKSLAQRVQENMIQ-EKQNLGQE--REEEEIRGLH--------------QSVRELQ 2100
Query: 233 ATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLA 292
T A+ E+++ LE + +LE HS T EE++ K E RL
Sbjct: 2101 LTLAQKEQEI---------LELRETQQRNNLEALPHS-HKTSPMEEQSLKLDSLE-PRLQ 2149
Query: 293 REKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQL 352
RE L+ LQ + + +A R EWR+ K +D A+
Sbjct: 2150 RE---------------LERLQAALRQTEA---------REIEWRE----KAQDLALSLA 2181
Query: 353 REDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLA 412
+ AS A Q S ++ RD + Q LQ+E + + + + L
Sbjct: 2182 QTKASVSSLQEVAMFLQAS--VLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 413 VERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQE 472
E+ ++ +V G++ + D +E+ ++ +Q Q A+L+ LQ
Sbjct: 2240 SRGEQGVQLGEVS-GVEAEPSPDGMEKQSWRQRLEHLQ-------QAVARLEIDRSRLQR 2291
Query: 473 QEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQR-LREQNTSL 531
V L++ + ++ + L+ + A L EISK SS Q+ R Q S
Sbjct: 2292 HNVQLRSTLEQVERERRKLKREAMRAAQAGSL------EISKATASSPTQQDGRGQKNSD 2345
Query: 532 RNAIAQMRKEMEALSHQI 549
+A+++KE+ L Q+
Sbjct: 2346 AKCVAELQKEVVLLQAQL 2363
Score = 76.3 bits (186), Expect = 1e-13
Identities = 185/849 (21%), Positives = 342/849 (40%), Gaps = 138/849 (16%)
Query: 12 ELLLRKEEEWRALQAHRTQLQ---EAALQDTRSQLEEAQG--KLRCLQEDFVYNLQ---- 62
E+L R +E AL + L+ +A +D + E+ QG + L E ++ Q
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 63 VLEERDLELERYDAAFAQAREWEEAR-RAEVSELKIEAAKLRQALAREARKVEELQQQQQ 121
V+E +LE QA+E + R EL E ++ Q AR++ + +Q+ +
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 122 LAFQE----HRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLE 177
A ++ H E+ ++ E H+++ +LER+ EL+ L Q+ E+
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM--- 898
Query: 178 FESKMRKREHEFRLQADN-MSNTALSREL-KVKLLHKELEALKEAGAKAAESLQRAEATN 235
E+ +RE E R QA++ + L E +V LL L+ KE A A++ L+R
Sbjct: 899 -EAIQAQREEE-RTQAESALCQMQLETEKERVSLLETLLQTQKEL-ADASQQLERLRQDM 955
Query: 236 AELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREK 295
+ K Q G LQ ++ +K+ + ++E + + +L + +
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
Query: 296 DAVLVAVKGAHVEQLQELQTRVLELQAH---------------CETLEAQLRRAEWRQAD 340
+ LVA + QE+Q ++ E Q + +E + R ++AD
Sbjct: 1016 KSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD 1075
Query: 341 T-------------------AKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQI 381
+ KE A ++ LR++ ++ + AQ AQL +E+ + +
Sbjct: 1076 SIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
Query: 382 QTLQEEEVKLKAQVARSQQDIERYKQQL-SLAVERERSLE-------------------- 420
Q L+ +A+ A+ Q + + QL +LA E++ +
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 421 ----RDQVQLGLDWQRRCDDIERDQ-----IQKSEALIQGLSMAKSQVAA---------K 462
R ++ G D +E DQ + K L+ LS A++ +A K
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS-AEAVASALHKLHQDLWK 1254
Query: 463 LQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISK-----DFP 517
Q+T L++Q V K D + ++H Q L Q++EE SK +
Sbjct: 1255 TQQTRDVLRDQ--VQKLEERLTDTEAEKSQVH-TELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 518 SSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPD 577
SE+ L E SL++ + R E++ + Q + AA+ A +
Sbjct: 1312 ESELMELHETMASLQSRL--RRAELQRMEAQGERELLQAAKE-----------NLTAQVE 1358
Query: 578 YVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAG 637
++ A E R LE+ L LK+ + ES+ AQA Q
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE----------RAQALQEQ 1408
Query: 638 GSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPR 697
G ++ Q G ++Q + L + L +R + + L ++++ + ++ AAL+ L
Sbjct: 1409 GELKVAQ-GKALQE---NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL-LSL 1463
Query: 698 EVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGREDAKSAE-DEA 756
++ + + EV ++Q+ EL K + +H R+Q + + RE + E D
Sbjct: 1464 DLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ-----KLTVQREQIRELEKDRE 1518
Query: 757 PSRHLGKHQ 765
R++ +HQ
Sbjct: 1519 TQRNVLEHQ 1527
Score = 56.2 bits (134), Expect = 1e-07
Identities = 97/423 (22%), Positives = 163/423 (38%), Gaps = 77/423 (18%)
Query: 23 ALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLEL----------- 71
A QAH QL+EA R Q E Q + QED Q L +RD EL
Sbjct: 2007 ACQAHSRQLEEAL----RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Query: 72 ----ERYDAAFAQARE--WEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQ 125
+R Q ++ +E E+ L +L+ LA++ +++ EL++ QQ
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQ---- 2118
Query: 126 EHRLELERV-HSDKNGEIDHHREQYENLKWTLERKLEELDG-----------------EL 167
R LE + HS K ++ + ++L+ L+R+LE L +L
Sbjct: 2119 --RNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDL 2176
Query: 168 ALQR----------QELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEAL 217
AL QE+ + ++ + +R+ E + D + T + E K +L +
Sbjct: 2177 ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE-KERLHSPGATST 2235
Query: 218 KEAGAKAAESLQRAEATNAELE-----RKLQSRAGELQDLE-AMSRARVKDLEDKLHSVQ 271
E G++ + +Q E + E E + QS L+ L+ A++R + + H+VQ
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
Query: 272 LT---RKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQ------------LQELQTR 316
L + E E K K E + + A + +Q + ELQ
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Query: 317 VLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVS 376
V+ LQA Q + R A T++E L V A +A + + +
Sbjct: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415
Query: 377 RDL 379
L
Sbjct: 2416 ESL 2418
Score = 55.8 bits (133), Expect = 2e-07
Identities = 156/763 (20%), Positives = 281/763 (36%), Gaps = 132/763 (17%)
Query: 8 PALNE-----LLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGK---LRCLQEDFVY 59
P LN L L EE+ ALQ + Q A+ + ++ E Q + +R LQ +
Sbjct: 6 PGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQ 65
Query: 60 NLQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQ 119
+E + LE Q WE + EL + R EE Q+
Sbjct: 66 YRSWCQELEKRLEATGGPIPQ--RWENVEEPNLDELLV-------------RLEEEQQRC 110
Query: 120 QQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFE 179
+ LA + N ++ H E+ + + L +E+L + + R EL+ + E
Sbjct: 111 ESLA-------------EVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRK-E 156
Query: 180 SKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
S+ + + F+ LS +V + +K A + L +A + L
Sbjct: 157 SQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDR---DLMELKAEHVRLS 213
Query: 240 RKLQSRAGEL----QDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREK 295
L + L Q E R+ E + L K +EL++ A E+
Sbjct: 214 GSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA----------KTQELEKEAHER 263
Query: 296 DAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRED 355
L+ +K + ELQ RV E L A L +++ + D K I LRE
Sbjct: 264 SQELIQLKSQGDLEKAELQDRVTE-------LSALLTQSQKQNEDYEK----MIKALRET 312
Query: 356 ASTVKSAWDAQIAQLSKEMVSRDLQI-QTLQEEEVKLKAQVARSQQDIERYKQQLSLAVE 414
+++ E++ + + + QEE++ L+ + Q + ++
Sbjct: 313 VEILETN--------HTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSG 364
Query: 415 RERSLERD-QVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQ 473
E SLE D + D+Q K+ L++ + + Q L++ QE
Sbjct: 365 HENSLELDSSIFSQFDYQ---------DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEA 415
Query: 474 EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRN 533
+L+ + ++ +ALR G + L ++ E+ L ++ L+
Sbjct: 416 VNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL-----QGEVDSLSKERELLQK 470
Query: 534 AIAQMRKEMEALSHQ------IPPPIQTAAESTDANQPDPEAGGDAAT------PDYVLA 581
A ++R+++E L + + +Q +S + + + A + ++
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
Query: 582 LEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQ 641
LEA+ + TL + LE S H E + + TE T A+A Q+ +
Sbjct: 531 LEAKQSESLSELITLREALE---------SSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 642 AGQ----------AGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAAL 691
+ + +V+ ++ LAL K+G QLL L + + +E A
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL---EEENQSVCSRMEAA-- 636
Query: 692 QRELPREVDQVHLEVLELRKQV-----AELGKHLRIAQHGGAE 729
E R QV L E R++ L L+ A+ GAE
Sbjct: 637 --EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Score = 53.9 bits (128), Expect = 7e-07
Identities = 141/645 (21%), Positives = 252/645 (39%), Gaps = 88/645 (13%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
EP L+ELL+R EEE Q L E Q R +E+A + L+ED +E+
Sbjct: 93 EPNLDELLVRLEEE----QQRCESLAEVNTQ-LRLHMEKADVVNKALRED-------VEK 140
Query: 67 RDLELER-YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQ 125
++ R D + +W+ + LK E +L +L RE + + A
Sbjct: 141 LTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL-LSLWREVVTFRRHFLEMKSATD 199
Query: 126 EHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQE-----LLLEFES 180
+EL+ H +G + L+ T+ + E +G + +E LLL
Sbjct: 200 RDLMELKAEHVRLSGSL-----LTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 181 KMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELER 240
++ K HE + + + + +++ EL AL K E ++ E
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
Query: 241 KLQSRAGELQDLEAMSRARVKDLEDKLHSV--QLTRKKEEE----TFKRKHE---ELDRL 291
L++ EL + EA ++ + L V +T+ EE HE ELD
Sbjct: 315 ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS 374
Query: 292 A------REKDAVLVAVKGAHV----------EQLQELQTRVLELQAHCETLEAQLRRAE 335
++ D L V+ +QL Q V LQ + E + +
Sbjct: 375 IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434
Query: 336 WRQADTAKEKDAAIDQLREDASTVKS-AWDAQIAQLSKEMVSRDLQI-----QTLQEEEV 389
R E+D Q + V S + + ++ Q ++E + + L++ L+ V
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
Query: 390 KLKAQVARSQQDIERYKQQLSLAV-ERER------SLERDQVQ-----LGLDWQRRCDDI 437
+L+ Q +Q E +++L LAV ERER LE Q + + L +
Sbjct: 495 ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL 554
Query: 438 ERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLP 497
E + +++ + + Q A+L +E L+ + L+A ++ +AL L
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL---ALD 611
Query: 498 RPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAA 557
+ G L Q EEE S ++ + +L+ +A+ K EAL + T
Sbjct: 612 KVGLNQQLLQLEEE--NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK-----NTHL 664
Query: 558 ESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLED 602
E+ Q EAG + L+A++R ++ + + ++K L +
Sbjct: 665 EA--QLQKAEEAGAE---------LQADLRDIQEEKEEIQKKLSE 698
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 102 bits (253), Expect = 2e-21
Identities = 127/603 (21%), Positives = 267/603 (44%), Gaps = 79/603 (13%)
Query: 1 MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN 60
+LP L E + R+EEE R Q + + QE + +L E +GK+R +E
Sbjct: 223 LLPQVQTNTLQEEMWRQEEELRE-QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQ 281
Query: 61 LQVLEERDLELERYDAAFAQA---REWEEARRAEVSELKIEAAKLRQALAREARKVEEL- 116
+ L E++ EL + + RE EE + + ++ + K+R+ + R+ E L
Sbjct: 282 EKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 117 QQQQQLAFQEHRLELERVHSDKNGEIDHH-REQYENLK-----WTLERKLEELDGELALQ 170
+Q++Q+ QE ++ R ++ E D RE+ E ++ W E K++E E +
Sbjct: 342 EQEKQMREQEQKM---RDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE--EERIRE 396
Query: 171 RQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQR 230
R++ + E E MR++E + + Q +NM +E + + L ++ E L E E +Q
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLPEQKEKLWEQ-----EKMQE 450
Query: 231 AEATNAELERKLQSRAGEL-QDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELD 289
E E E K++ + Q+ + + ++++ ED++ + + +E+ + E +
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM- 509
Query: 290 RLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAI 349
E+D E+L+E + R+ E ++ W+Q + +E+
Sbjct: 510 ---WEQD-----------ERLREKEERMRE------------QKKMWQQEEKMREEKKTQ 543
Query: 350 DQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQL 409
+Q K WD Q ++ +E R+ + + ++EEE ++ Q + Q+ E+ ++Q
Sbjct: 544 EQ-------EKKTWD-QEEKMREEERMRERE-KKMREEEEMMREQEEKMQEQEEKMREQE 594
Query: 410 SLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQA 469
E+E ++ + ++ ++ + E D++Q+ E ++ + K+ E E+
Sbjct: 595 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Query: 470 LQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEI----SKDFPSSE----- 520
++EQE ++ + + +R G + +R+ EE++ K + E
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQ 714
Query: 521 ------IQRLREQNTSLRNAIAQMRKEM----EALSHQIPPPIQTAAESTDANQPDPEAG 570
+ +RE+ +R+ +M++ + E S PP + + +P AG
Sbjct: 715 EEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEP-AG 773
Query: 571 GDA 573
G+A
Sbjct: 774 GEA 776
Score = 55.1 bits (131), Expect = 3e-07
Identities = 80/362 (22%), Positives = 153/362 (42%), Gaps = 26/362 (7%)
Query: 202 SRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVK 261
S E + K H+ EAL+ +++ ELE L + E + K
Sbjct: 68 SPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESK 127
Query: 262 DLEDKLH-------SVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQ 314
DL +LH +Q K+ ++ L +E+DA+ + + + +EL+
Sbjct: 128 DLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITN-EELK 186
Query: 315 TRVLELQ-----AHCETLEAQLRRAEW-RQADTAK--EKDAAIDQLREDASTVKSAWDAQ 366
+ ELQ A E E QL E R+ + AK + L+E+ + Q
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 367 IAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQL 426
++ K+ Q + L+E+E K++ Q + ++ +R ++Q E+E+ L R+Q +L
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL-REQKKL 305
Query: 427 GLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQ 486
++ + E+ Q+ + Q M + + +L E E+ ++EQE + RDQ
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQE--ERLWEQEKQMREQEQKM------RDQ 357
Query: 487 AVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALS 546
+ R + +R+ E+ ++ E +R+RE+ +R MR++ E +
Sbjct: 358 EERMWEQDERLREKEER-MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQ 416
Query: 547 HQ 548
Q
Sbjct: 417 KQ 418
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 101 bits (252), Expect = 3e-21
Identities = 132/544 (24%), Positives = 237/544 (43%), Gaps = 50/544 (9%)
Query: 16 RKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYD 75
R EE WR R + QE ++ R++ E+ Q E+F Q+ LEL R
Sbjct: 169 RDEELWR----QRQEWQER--EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 76 AAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKV--EELQQQQQLAFQEHRL-ELE 132
Q + E R E + E K L +E K+ EE Q+Q++L +E +L +LE
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQ 192
R + + + ++Q + L RK EE E +R+E E + +RE + R +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 193 ADNMSNTALSRELKVKLLHKEL-----EALKEAGAKAAESLQRAEATNAELERKLQSRAG 247
+ L RE + + ++L E +E + + L+R + E + + + +
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 248 ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV 307
Q L + R + + QL R++EEE ++KHE+ R R K
Sbjct: 403 REQQLRREQQLRRE--QQLRREQQLRREQEEERHEQKHEQERREQRLK---------REQ 451
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQI 367
E+ ++ R E + H Q RR + + D +E+ +L E+ + + +
Sbjct: 452 EERRDWLKREEETERH-----EQERRKQQLKRDQEEERRERWLKLEEEER--REQQERRE 504
Query: 368 AQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLG 427
QL +E R Q QEEE +L+ Q RS+Q + R +++ RE+ L+R++ +
Sbjct: 505 QQLRREQEERREQRLKRQEEEERLQ-QRLRSEQQLRREQEE-----RREQLLKREE-EKR 557
Query: 428 LDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQE--TEQALQEQEVVLKAVTLERD 485
L+ +RR ++R+Q ++ + L++ + Q + QE EQ L+ +EV + +
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE---QEE 614
Query: 486 QAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEAL 545
+ Q L+ Q LL+ E+E + Q+LR + R + +E E L
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQ------QQLRREQQERREQRLKREEEEERL 668
Query: 546 SHQI 549
++
Sbjct: 669 EQRL 672
Score = 97.1 bits (240), Expect = 7e-20
Identities = 128/536 (23%), Positives = 237/536 (44%), Gaps = 60/536 (11%)
Query: 16 RKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYD 75
R+EE+ R + QL+E Q R + +E + +L E+ + LE+RD + R +
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL-AEGEEQSEKQERLEQRDRQ-RRDE 171
Query: 76 AAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVH 135
+ Q +EW+E E ++++ K + EE ++QL +E LEL R
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCK--------GHETEEFPDEEQLRRRE-LLELRRKG 222
Query: 136 SDKNGEIDHHR-----EQYENLKW----TLERKLEELDGELALQRQELLLEFESKMRKRE 186
++ + R ++ E +W T+ RK EE E QRQ L E E ++RK E
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 187 HE---FRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
+ Q + L RE +++ K+ E +E + E +R E E++L+
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLR--RKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
E ++ + ++ E++ QL R++EEE +++ +L RE+ + +
Sbjct: 341 REQEERREQQLR-----REQEEERREQQLRREQEEERREQQLRREQQLRREQQ-LRREQQ 394
Query: 304 GAHVEQLQELQTRVLELQAHCE---TLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVK 360
+QL+ Q E Q E E QLRR + + K + +Q + +
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 361 SAWDAQIAQLSK-EMVSRDLQIQTLQEEE-----VKLKAQVARSQQDIERYKQQLSLAVE 414
W + + + E R Q++ QEEE +KL+ + R QQ ER +QQL E
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ--ERREQQLRREQE 512
Query: 415 --RERSLERDQVQLGLDWQRRCD-DIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQ 471
RE+ L+R + + L + R + + R+Q ++ E L++ + + + + EQ L+
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK----REEEKRLEQERREQRLK 568
Query: 472 EQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQ 527
++ + L+R++ + Q L R+ EE + + E++RL ++
Sbjct: 569 REQEERRDQLLKREEERR-----------QQRLKREQEERLEQRLKREEVERLEQE 613
Score = 86.3 bits (212), Expect = 1e-16
Identities = 145/620 (23%), Positives = 249/620 (40%), Gaps = 116/620 (18%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQ-----------DTRS------------------- 41
E LLR+E+E R + R +E LQ D RS
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Query: 42 -----------QLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRA 90
QLE++Q + R Q+D + L +ERD E ER R W++ R
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER--------RRWQQRDRH 1292
Query: 91 EVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDK----NGEIDHHR 146
E ++E + ++A R+ + Q+++QL +E + R +D+ ++ R
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKS----QEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348
Query: 147 EQYENLKWTLERKLEE------------LDGELALQRQE---LLLEFESKMRKREHEFRL 191
E+ + +RK E L+ E L+RQE L+ E ++R +E E +L
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 192 QAD-----NMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRA 246
+ D LSR+ + + +E + ++ + + L+ + E RK +
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ-ERERKFLEEEQQLRQERHRKFREEE 1467
Query: 247 GELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAH 306
LQ+ E E +LH + RK EE + + +E DR RE++ +
Sbjct: 1468 QLLQERE----------EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 307 VEQLQELQTRVLELQAHCETLEAQLRRAEWRQ-----ADTAKEKDAAIDQLREDASTVKS 361
+E+ Q+L + + Q E QLRR E Q D ++ + Q RE+ +
Sbjct: 1518 LEEEQQLHRQ--QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIER---YKQQLSLAVERERS 418
D + +L ++ V R Q + E+E +L+ Q + Q ER +++ L ERE
Sbjct: 1576 ERDRKF-RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 419 ----LERDQVQL----GLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQAL 470
ERD+ L L Q R + D+ +K Q L + Q + QE ++
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ-QLRRQERDRKF 1693
Query: 471 QEQEVVLKAVTLERD--QAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQN 528
+E+E L+ ER Q Q LR L R + EE++ ++ +++R
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERK------FREEEQLRQETEQEQLRRQERYR 1747
Query: 529 TSLRNAIAQMRKEMEALSHQ 548
L + +E + L Q
Sbjct: 1748 KILEEEQLRPEREEQQLRRQ 1767
Score = 83.2 bits (204), Expect = 1e-15
Identities = 151/604 (25%), Positives = 256/604 (42%), Gaps = 96/604 (15%)
Query: 15 LRKEEEWRALQAHRTQLQEAAL-QDTRSQLEEAQGKLR-------CLQEDFVYNLQVLEE 66
L++EE+ R + QE Q R QLEE + + R LQE Q+L+E
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 67 RDLELERYD-------AAFAQAREWEEARRAEVSELKIEAAK-LRQALAREARKVEELQQ 118
+ EL+R + Q RE E+ ++ E L+ E K RQ R+ RK ++LQQ
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 119 QQQLAFQEH------------RLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGE 166
+++ E E E + ++ + RE+ +W ER+ + D E
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW--ERQYRKKD-E 1025
Query: 167 LALQRQELLLEFESKMR--KREHEFR----LQADNMSNTALSRELKVKL-LHKELEALKE 219
L + ++LL E K R +RE ++R LQ + RE + + L ++ +E
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 220 AGAKAAESLQRAEATNAELERKLQSR-AGELQD------LEAMSRARVKDLEDKLHSVQL 272
+ + L+ ER+ Q R ELQ E + R ++LE + +
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Query: 273 TRKKE-----EETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVL--ELQAHCE 325
+++E EE KR+ +EL+R RE+ E+LQ+ + ++L E + +
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELERQYREE------------EELQQEEEQLLREEQEKRRQ 1193
Query: 326 TLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQI---- 381
E Q R E Q K++ DQ S +K W+ + KE RD ++
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQ----RSDLKWQWEPE-----KENAVRDNKVYCKG 1244
Query: 382 ----QTLQEEEVKLKAQVARSQQDIERY---KQQLSLAVERERSLERD-----QVQLGLD 429
Q Q E+ +L+ + +SQQD++ +Q+ ER R +RD + QL +
Sbjct: 1245 RENEQFRQLEDSQLRDR--QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 430 WQRRCDDIERDQIQKSEALIQGL--SMAKSQVAAKLQETEQALQE-QEVVLKAVTLERDQ 486
Q+ +R ++ + L + + + K +E EQ LQE +E L+ +R
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 487 AVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQ-RLREQNTSLR-NAIAQMRKEMEA 544
+ LR R + R +E + F E Q R +E+ LR + + R+E +
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422
Query: 545 LSHQ 548
LS Q
Sbjct: 1423 LSRQ 1426
Score = 82.0 bits (201), Expect = 2e-15
Identities = 131/551 (23%), Positives = 244/551 (44%), Gaps = 64/551 (11%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
EP L +EE+ R L+ R +L+ R + EE Q + R +E + Q E
Sbjct: 264 EPQRQRELQEEEEQLRKLE--RQELR-------RERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 67 RDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQE 126
R+ + ER + + RE +E RR + +L+ E + R+ R ++ E +QQ + +E
Sbjct: 315 REQQEERREQ--QERREQQEERREQ--QLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 127 HRLELE-RVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKR 185
R E + R E REQ + L R+ ++L E L+R++ L + R++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQ 429
Query: 186 EHEFRLQADNMS--NTALSRELKVK--LLHKELEALKEAGAKAAESLQRAEATNAELERK 241
E E Q L RE + + L +E E + + + L+R + ER
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR-DQEEERRERW 488
Query: 242 LQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVA 301
L+ E ++ + +++ +++ +L R++EEE +++ +L RE++
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE----- 543
Query: 302 VKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKS 361
E+ ++L R E + E E +L+R + + D +++ Q R +K
Sbjct: 544 ------ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR-----LKR 592
Query: 362 AWDAQIAQ-LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLE 420
+ ++ Q L +E V R E+E + + ++ R + + ER +QQL + E+E E
Sbjct: 593 EQEERLEQRLKREEVER-------LEQEERREQRLKREEPEEER-RQQLLKSEEQE---E 641
Query: 421 RDQVQLGLDWQ-RRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKA 479
R Q QL + Q RR ++R+ ++ E L Q L K + + +E E A +EQE +
Sbjct: 642 RRQQQLRREQQERREQRLKRE--EEEERLEQRL---KREHEEERREQELAEEEQEQARER 696
Query: 480 V---------TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTS 530
+ LE + + +++ PR RQ +EE + SE+Q E+
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE-KRRRRESELQWQEEERAH 755
Query: 531 LRNAIAQMRKE 541
+ + R++
Sbjct: 756 RQQQEEEQRRD 766
Score = 82.0 bits (201), Expect = 2e-15
Identities = 115/578 (19%), Positives = 240/578 (41%), Gaps = 55/578 (9%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
E E L++E+E R Q + + + + R Q E + +L+ + V L+ E
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK---REEVERLEQEER 615
Query: 67 RDLELERYDAAFAQAREW---EEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
R+ L+R + + ++ EE +L+ E + R+ + + E L+Q+ +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGEL-----ALQRQELLLEF 178
+E R E E ++ + + + +W LE + + ++ + Q E
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVK-------------------LLHKELEALKE 219
E K R+RE E + Q + ++ E + + L +E
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 220 AGAKAAESLQRAEATNAELERKLQ------SRAGELQDLE----AMSRARVKDL---EDK 266
+A E QR + E E K Q R ELQ LE R R + L ED
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 267 LHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCET 326
L Q R+ +E+ +K R++ + K A EQL++ Q + E + +
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 327 LEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQE 386
E + RR + ++ +E+ +E+ ++ + + Q + +D ++Q +E
Sbjct: 916 EEREKRRRQEQERQYREEEQLQ----QEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 387 EEVKLKAQVARSQQDIERYKQQLSLAVERERSL-ERDQVQLGLDWQRRCDDIERDQIQKS 445
+ + + + R Q+ ++Y+++ L E E+ L E + + +W+R+ ++D++Q+
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR--KKDELQQE 1029
Query: 446 EALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRP-GAQML 504
E + + + + +LQE E+ +E+E + + + + R L R +
Sbjct: 1030 EEQL----LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 505 LRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEM 542
L+Q EE++ ++ P ++ RE+ + Q +++
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Score = 80.1 bits (196), Expect = 9e-15
Identities = 107/456 (23%), Positives = 205/456 (44%), Gaps = 42/456 (9%)
Query: 16 RKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYD 75
R+EE+ Q R + + L++ + +E K R +E+ + LQ EE+ L + D
Sbjct: 1433 REEEQ----QVRRQERERKFLEEEQQLRQERHRKFR--EEEQL--LQEREEQQLHRQERD 1484
Query: 76 AAFA----QAREWEEARRAEVSELKIEAAKLR-----QALAREARKVEELQQQQQLAFQE 126
F Q R E R+ EL+ + + + Q L R+ R+ + LQ++QQL QE
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 127 H----RLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQEL-LLEFESK 181
R + +R ++ ++ RE+ + + +RK + ++ Q QE +E E +
Sbjct: 1545 RGQQRRQDRDRKFREEE-QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 182 MRKREHEFRLQADN----MSNTALSRELKVKLLHKE------LEALKEAGAKAAESLQRA 231
+R++E + +L+ + + L +E + + LH++ LE + + E R
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 232 EATNAELERKLQSRAGELQDLEAMSRAR-VKDLEDKLHSVQLTRKKEEETFKRKHEELDR 290
+ E + + GE Q L R R ++ E +L + RK +E + + +EL+R
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 291 LAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAE----WRQADTAKEKD 346
RE++ + + + + + + + E Q E E QLRR E +R+ + ++ +
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ-E 1782
Query: 347 AAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQ---TLQEEEVKLKAQVARSQQDIE 403
QLR S K + Q+ Q +E R Q +EE+++L+ Q R +Q+ +
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 404 RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIER 439
R + +E+S +Q + Q+R + ER
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER 1878
Score = 36.2 bits (82), Expect = 0.14
Identities = 38/125 (30%), Positives = 55/125 (44%), Gaps = 18/125 (14%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY 74
LR+E E + L++ + + + R + EE Q LR Q D Y EE L+LE
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQ--LRPQQRDGKYRW---EEEQLQLEEQ 1833
Query: 75 DAAFAQARE-----------WEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
+ Q R+ E++RR E + E K RQ R+ R EE ++QQ
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR--EEHIRRQQKE 1891
Query: 124 FQEHR 128
Q HR
Sbjct: 1892 EQRHR 1896
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 100 bits (249), Expect = 6e-21
Identities = 131/555 (23%), Positives = 256/555 (46%), Gaps = 81/555 (14%)
Query: 25 QAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREW 84
Q Q +E LQ T+ + ++A+ +L+ L++ + Q+ EE++L E+ A
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQK---HSQLTEEKNLLQEQLQAE------- 899
Query: 85 EEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDH 144
+EL EA ++R LA + +++EE+ + E RLE E D+ ++
Sbjct: 900 --------TELYAEAEEMRVRLAAKKQELEEILHEM-----EARLEEEE---DRGQQLQA 943
Query: 145 HREQYENLKWTLERKLEELDGELALQRQELLLE---FESKMRKREHEFRLQADNMSNTAL 201
R++ LE +LEE + RQ+L LE E+K++K E E + D + +
Sbjct: 944 ERKKMAQQMLDLEEQLEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 202 SREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSR- 257
R+L ++ L L +E + + E+ +ELE +L+ Q+LE + R
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 258 --ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDR-LAREKDAVLVAVKGAHVEQLQELQ 314
D +++ +Q + + +K EEL LAR D + A K +++++EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELE 1117
Query: 315 TRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRE--DASTVKSAWDAQIAQ--- 369
+ +LQ ++ A +AE ++ D +E +A +L + D++ + A+ Q
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 370 -----LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQV 424
L +E S + Q+Q ++++ + ++ + +R K L + +++LE++
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD---KNKQTLEKENA 1234
Query: 425 QLGLDWQ---RRCDDIERDQIQKSEALIQGLSMAKS---QVAAKLQETEQALQEQ----- 473
L + + + ++E + +K EA +Q L S + A+L + LQ +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 474 ----EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNT 529
E KA+ L +D A + ++ Q LL+ EE K S+++++L E+
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQ-----DTQELLQ--EETRQKLNVSTKLRQLEEERN 1346
Query: 530 SLRNAIAQMRKEMEA 544
SL++ Q+ +EMEA
Sbjct: 1347 SLQD---QLDEEMEA 1358
Score = 90.9 bits (224), Expect = 5e-18
Identities = 127/598 (21%), Positives = 262/598 (43%), Gaps = 73/598 (12%)
Query: 7 EPALNELLLRKEEEWRA---LQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQV 63
E N L + +EE A L+ H + L L D++ +L++ + L+E +
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLN-IQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 64 LEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
+E + E AA+ + + + + E+ +L ++ RQ ++ +K + Q L
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ---LL 1457
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
+E + + ++D+ + + E +L R LEE AL+ +E L E +KM
Sbjct: 1458 AEEKNISSK--YADERDRAEAEAREKETKALSLARALEE-----ALEAKEEL-ERTNKML 1509
Query: 184 KREHEFRLQA-DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKL 242
K E E + + D++ E + L ++E +K + + LQ E LE +
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 243 QSRAGELQ-DLEA---MSRARVKDLEDKLHSVQLTRKKEEE------TFKRKHE-ELDRL 291
Q+ G+ + DL+A + + + L+ +LH + + E + K+K E +L L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 292 AREKDAVLVAVKGAH--VEQLQELQTRVLELQAHCETLEA---QLRRAEWRQADTAKEKD 346
+ D+ A+KG ++QL++LQ ++ + Q E A ++ AK +
Sbjct: 1630 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 347 AAIDQLREDASTVKSAW---DAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIE 403
A + QL+ED + + A D + +L++E+ S LQ+E+ +L+A++A+ ++++E
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 404 RYK-----------------QQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSE 446
+ +QLS + ERS + +R+ ++ R ++ + E
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL-RSKLHEME 1805
Query: 447 ALIQGLSMAKSQVA---AKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQM 503
++ S KS +A AK+ + E+ ++++ +A T Q + L+ L +
Sbjct: 1806 GAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1863
Query: 504 LLRQHEEEISK------------DFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549
+ Q++E+ K + E QR+ L+ + + + EA+ ++
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Score = 85.9 bits (211), Expect = 2e-16
Identities = 153/653 (23%), Positives = 275/653 (42%), Gaps = 107/653 (16%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQ---DTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
LN+ + + + E ++ + + A++ D S + Q LQE+ L V +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 67 -RDLELERYDAAFAQAREWEEARRAE--VSELKIEAAKLRQALAREARKVEELQQQQQLA 123
R LE ER E E + E +S L I+ + ++ L A VE L++ ++
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK-R 1396
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
FQ+ L + + +K D + E K L+++L++L +L QRQ L+ E K R
Sbjct: 1397 FQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQ-LVSNLEKKQR 1451
Query: 184 KREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
K + +LL +E K +K A+ RAEA E E K
Sbjct: 1452 KFD---------------------QLLAEE----KNISSKYADERDRAEAEAREKETK-- 1484
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
A+S AR LE+ L + +++ E T K E++ L KD V
Sbjct: 1485 ----------ALSLARA--LEEALEA----KEELERTNKMLKAEMEDLVSSKDDV----- 1523
Query: 304 GAHVEQLQE----LQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
G +V +L++ L+T++ E++ E LE +L+ E D + + L+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEVNMQALKGQFERD 1579
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAV------ 413
A D Q + +++ + + +T E+E K +A A +++ +E + L L
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 414 --ERERSLERDQVQLGLDWQRRCDD--IERDQI--------QKSEALIQGLSMAKSQVAA 461
E + L + Q Q+ D+QR +D RD+I +K+++L L + +AA
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 462 KLQETEQALQEQEVVLK--AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS 519
+ +QA E+E + + A +L A+Q + L AQ+ EE+ + + S
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSD 1757
Query: 520 EIQRLREQ-----------------NTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDA 562
+++ +Q N S R + + KE+ + H++ +++ +ST A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 563 NQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE 615
A + +A ++LK K K L++ L V D KM+ + E
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Score = 84.3 bits (207), Expect = 5e-16
Identities = 105/463 (22%), Positives = 206/463 (44%), Gaps = 33/463 (7%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
+E+E +AL R L+EA + + +LE L+ ED V + + + ELE+
Sbjct: 1479 REKETKALSLARA-LEEAL--EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 77 AFAQAREWEEARRAEVSE--LKIEAAKLRQALAREARK--VEELQQQQQLAFQEHRLELE 132
A E + + E+ + E AKLR + +A K E Q + +E R +L+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLE------ELDGELALQRQELLLEFESKMRKRE 186
R + E++ R+Q L ++KLE EL + A++ +E ++ K++ +
Sbjct: 1596 RQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 187 HEF-------RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
+F R D + TA E K K L +L L+E A A + ++A+ EL
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 240 RKLQSRAG---ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKD 296
+L S LQD + AR+ LE++L Q + + ++ ++ ++L+ E
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL- 1773
Query: 297 AVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDA 356
A + + Q+L+ + EL++ +E ++ + K A +++ E
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 357 STVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ K A + Q K++ LQ++ ++ + K Q + +++ K+QL A E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQV 459
+ + ++ +L QR D + + +EA+ + ++ KS++
Sbjct: 1894 QRINANRRKL----QRELD----EATESNEAMGREVNALKSKL 1928
Score = 82.8 bits (203), Expect = 1e-15
Identities = 121/550 (22%), Positives = 244/550 (44%), Gaps = 59/550 (10%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L + EE R A + Q E L + ++LEE + + + LQ + + + ++ L+LE
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE----RKKMAQQMLDLEE 957
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
Q E E AR+ +L++E + + ++ + Q +E +L ER
Sbjct: 958 ------QLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 134 VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA 193
+ SD + E+ +NL L+ K E + EL E+ L+ E K R+ + + +
Sbjct: 1008 I-SDLTTNLAEEEEKAKNLT-KLKNKHESMISEL-----EVRLKKEEKSRQELEKLKRK- 1059
Query: 194 DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLE 253
+ A ++ L ++ LK AK E LQ A A L+ ++ + L+ +
Sbjct: 1060 --LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIR 1114
Query: 254 AMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQEL 313
+ + DL++ L S + R K E+ + EEL+ L E + L + QEL
Sbjct: 1115 EL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS-----TATQQEL 1168
Query: 314 QT-RVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSK 372
+ R E+ + L+ + R E + + ++ A+++L E Q+ Q +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-----------QLEQFKR 1217
Query: 373 EMVSRDLQIQTLQEEEVKLKAQ---VARSQQDIERYKQQLSLAVERERSL----ERDQVQ 425
+ D QTL++E L + + +++Q++E K++L V+ +S ER + +
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 426 LGLDWQRRCDDIERDQIQKSEALIQGLSMAK--SQVAAKLQETEQALQE---QEVVLKAV 480
L + +++E +EA + + +AK + ++++LQ+T++ LQE Q++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS--EIQRLREQNTSLRNAIAQM 538
+ ++ +L+ A+ L +H ++ S ++Q +L +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 539 RKEMEALSHQ 548
+KE+E L+ Q
Sbjct: 1398 QKEIENLTQQ 1407
Score = 58.5 bits (140), Expect = 3e-08
Identities = 93/447 (20%), Positives = 190/447 (42%), Gaps = 75/447 (16%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK--------------LQSRA---G 247
L+V +E++A ++ K E Q+AE ELE+K LQ+
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 248 ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV 307
E +++ A+ ++LE+ LH ++ ++EE+ ++ E ++A++ +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL--------E 956
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQI 367
EQL+E + +LQ T EA++++ E ++ +D S + + +I
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLE--------DEILVMDDQNNKLSKERKLLEERI 1008
Query: 368 AQLSKEMVSRDLQIQTL-----------QEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ L+ + + + + L E EV+LK + +S+Q++E+ K++L E +
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKL----EGD 1063
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVA------AKLQETEQAL 470
S +Q+ D Q + +++ +K E L L+ ++A K++E E +
Sbjct: 1064 ASDFHEQI---ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 471 QEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQN-T 529
+ + L + R++A + R G + L + E+ + E++ REQ T
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 530 SLRNAIAQMRKEMEALSHQI-PPPIQTAAESTDANQPDPEAGGDAATPDYVLA-----LE 583
L+ A+ + + EA ++ Q E T+ + A + L L
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 584 AEIRTL-------KHKFKTLEKHLEDV 603
E+R L +HK K LE ++++
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQEL 1264
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 100 bits (249), Expect = 6e-21
Identities = 131/555 (23%), Positives = 256/555 (46%), Gaps = 81/555 (14%)
Query: 25 QAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREW 84
Q Q +E LQ T+ + ++A+ +L+ L++ + Q+ EE++L E+ A
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQK---HSQLTEEKNLLQEQLQAE------- 906
Query: 85 EEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDH 144
+EL EA ++R LA + +++EE+ + E RLE E D+ ++
Sbjct: 907 --------TELYAEAEEMRVRLAAKKQELEEILHEM-----EARLEEEE---DRGQQLQA 950
Query: 145 HREQYENLKWTLERKLEELDGELALQRQELLLE---FESKMRKREHEFRLQADNMSNTAL 201
R++ LE +LEE + RQ+L LE E+K++K E E + D + +
Sbjct: 951 ERKKMAQQMLDLEEQLEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 202 SREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSR- 257
R+L ++ L L +E + + E+ +ELE +L+ Q+LE + R
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 258 --ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDR-LAREKDAVLVAVKGAHVEQLQELQ 314
D +++ +Q + + +K EEL LAR D + A K +++++EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELE 1124
Query: 315 TRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRE--DASTVKSAWDAQIAQ--- 369
+ +LQ ++ A +AE ++ D +E +A +L + D++ + A+ Q
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 370 -----LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQV 424
L +E S + Q+Q ++++ + ++ + +R K L + +++LE++
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD---KNKQTLEKENA 1241
Query: 425 QLGLDWQ---RRCDDIERDQIQKSEALIQGLSMAKS---QVAAKLQETEQALQEQ----- 473
L + + + ++E + +K EA +Q L S + A+L + LQ +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 474 ----EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNT 529
E KA+ L +D A + ++ Q LL+ EE K S+++++L E+
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQ-----DTQELLQ--EETRQKLNVSTKLRQLEEERN 1353
Query: 530 SLRNAIAQMRKEMEA 544
SL++ Q+ +EMEA
Sbjct: 1354 SLQD---QLDEEMEA 1365
Score = 90.9 bits (224), Expect = 5e-18
Identities = 127/598 (21%), Positives = 262/598 (43%), Gaps = 73/598 (12%)
Query: 7 EPALNELLLRKEEEWRA---LQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQV 63
E N L + +EE A L+ H + L L D++ +L++ + L+E +
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLN-IQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 64 LEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
+E + E AA+ + + + + E+ +L ++ RQ ++ +K + Q L
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ---LL 1464
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
+E + + ++D+ + + E +L R LEE AL+ +E L E +KM
Sbjct: 1465 AEEKNISSK--YADERDRAEAEAREKETKALSLARALEE-----ALEAKEEL-ERTNKML 1516
Query: 184 KREHEFRLQA-DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKL 242
K E E + + D++ E + L ++E +K + + LQ E LE +
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 243 QSRAGELQ-DLEA---MSRARVKDLEDKLHSVQLTRKKEEE------TFKRKHE-ELDRL 291
Q+ G+ + DL+A + + + L+ +LH + + E + K+K E +L L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 292 AREKDAVLVAVKGAH--VEQLQELQTRVLELQAHCETLEA---QLRRAEWRQADTAKEKD 346
+ D+ A+KG ++QL++LQ ++ + Q E A ++ AK +
Sbjct: 1637 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 347 AAIDQLREDASTVKSAW---DAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIE 403
A + QL+ED + + A D + +L++E+ S LQ+E+ +L+A++A+ ++++E
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 404 RYK-----------------QQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSE 446
+ +QLS + ERS + +R+ ++ R ++ + E
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL-RSKLHEME 1812
Query: 447 ALIQGLSMAKSQVA---AKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQM 503
++ S KS +A AK+ + E+ ++++ +A T Q + L+ L +
Sbjct: 1813 GAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1870
Query: 504 LLRQHEEEISK------------DFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549
+ Q++E+ K + E QR+ L+ + + + EA+ ++
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Score = 85.9 bits (211), Expect = 2e-16
Identities = 153/653 (23%), Positives = 275/653 (42%), Gaps = 107/653 (16%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQ---DTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
LN+ + + + E ++ + + A++ D S + Q LQE+ L V +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 67 -RDLELERYDAAFAQAREWEEARRAE--VSELKIEAAKLRQALAREARKVEELQQQQQLA 123
R LE ER E E + E +S L I+ + ++ L A VE L++ ++
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK-R 1403
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
FQ+ L + + +K D + E K L+++L++L +L QRQ L+ E K R
Sbjct: 1404 FQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQ-LVSNLEKKQR 1458
Query: 184 KREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
K + +LL +E K +K A+ RAEA E E K
Sbjct: 1459 KFD---------------------QLLAEE----KNISSKYADERDRAEAEAREKETK-- 1491
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
A+S AR LE+ L + +++ E T K E++ L KD V
Sbjct: 1492 ----------ALSLARA--LEEALEA----KEELERTNKMLKAEMEDLVSSKDDV----- 1530
Query: 304 GAHVEQLQE----LQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
G +V +L++ L+T++ E++ E LE +L+ E D + + L+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEVNMQALKGQFERD 1586
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAV------ 413
A D Q + +++ + + +T E+E K +A A +++ +E + L L
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 414 --ERERSLERDQVQLGLDWQRRCDD--IERDQI--------QKSEALIQGLSMAKSQVAA 461
E + L + Q Q+ D+QR +D RD+I +K+++L L + +AA
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 462 KLQETEQALQEQEVVLK--AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS 519
+ +QA E+E + + A +L A+Q + L AQ+ EE+ + + S
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSD 1764
Query: 520 EIQRLREQ-----------------NTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDA 562
+++ +Q N S R + + KE+ + H++ +++ +ST A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 563 NQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE 615
A + +A ++LK K K L++ L V D KM+ + E
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Score = 84.3 bits (207), Expect = 5e-16
Identities = 105/463 (22%), Positives = 206/463 (44%), Gaps = 33/463 (7%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
+E+E +AL R L+EA + + +LE L+ ED V + + + ELE+
Sbjct: 1486 REKETKALSLARA-LEEAL--EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 77 AFAQAREWEEARRAEVSE--LKIEAAKLRQALAREARK--VEELQQQQQLAFQEHRLELE 132
A E + + E+ + E AKLR + +A K E Q + +E R +L+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLE------ELDGELALQRQELLLEFESKMRKRE 186
R + E++ R+Q L ++KLE EL + A++ +E ++ K++ +
Sbjct: 1603 RQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 187 HEF-------RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
+F R D + TA E K K L +L L+E A A + ++A+ EL
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 240 RKLQSRAG---ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKD 296
+L S LQD + AR+ LE++L Q + + ++ ++ ++L+ E
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL- 1780
Query: 297 AVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDA 356
A + + Q+L+ + EL++ +E ++ + K A +++ E
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 357 STVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ K A + Q K++ LQ++ ++ + K Q + +++ K+QL A E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQV 459
+ + ++ +L QR D + + +EA+ + ++ KS++
Sbjct: 1901 QRINANRRKL----QRELD----EATESNEAMGREVNALKSKL 1935
Score = 82.8 bits (203), Expect = 1e-15
Identities = 121/550 (22%), Positives = 244/550 (44%), Gaps = 59/550 (10%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L + EE R A + Q E L + ++LEE + + + LQ + + + ++ L+LE
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE----RKKMAQQMLDLEE 964
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
Q E E AR+ +L++E + + ++ + Q +E +L ER
Sbjct: 965 ------QLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 134 VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA 193
+ SD + E+ +NL L+ K E + EL E+ L+ E K R+ + + +
Sbjct: 1015 I-SDLTTNLAEEEEKAKNLT-KLKNKHESMISEL-----EVRLKKEEKSRQELEKLKRK- 1066
Query: 194 DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLE 253
+ A ++ L ++ LK AK E LQ A A L+ ++ + L+ +
Sbjct: 1067 --LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIR 1121
Query: 254 AMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQEL 313
+ + DL++ L S + R K E+ + EEL+ L E + L + QEL
Sbjct: 1122 EL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS-----TATQQEL 1175
Query: 314 QT-RVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSK 372
+ R E+ + L+ + R E + + ++ A+++L E Q+ Q +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-----------QLEQFKR 1224
Query: 373 EMVSRDLQIQTLQEEEVKLKAQ---VARSQQDIERYKQQLSLAVERERSL----ERDQVQ 425
+ D QTL++E L + + +++Q++E K++L V+ +S ER + +
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 426 LGLDWQRRCDDIERDQIQKSEALIQGLSMAK--SQVAAKLQETEQALQE---QEVVLKAV 480
L + +++E +EA + + +AK + ++++LQ+T++ LQE Q++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS--EIQRLREQNTSLRNAIAQM 538
+ ++ +L+ A+ L +H ++ S ++Q +L +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 539 RKEMEALSHQ 548
+KE+E L+ Q
Sbjct: 1405 QKEIENLTQQ 1414
Score = 58.5 bits (140), Expect = 3e-08
Identities = 93/447 (20%), Positives = 190/447 (42%), Gaps = 75/447 (16%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK--------------LQSRA---G 247
L+V +E++A ++ K E Q+AE ELE+K LQ+
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 248 ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV 307
E +++ A+ ++LE+ LH ++ ++EE+ ++ E ++A++ +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL--------E 963
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQI 367
EQL+E + +LQ T EA++++ E ++ +D S + + +I
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLE--------DEILVMDDQNNKLSKERKLLEERI 1015
Query: 368 AQLSKEMVSRDLQIQTL-----------QEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ L+ + + + + L E EV+LK + +S+Q++E+ K++L E +
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKL----EGD 1070
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVA------AKLQETEQAL 470
S +Q+ D Q + +++ +K E L L+ ++A K++E E +
Sbjct: 1071 ASDFHEQI---ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 471 QEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQN-T 529
+ + L + R++A + R G + L + E+ + E++ REQ T
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 530 SLRNAIAQMRKEMEALSHQI-PPPIQTAAESTDANQPDPEAGGDAATPDYVLA-----LE 583
L+ A+ + + EA ++ Q E T+ + A + L L
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 584 AEIRTL-------KHKFKTLEKHLEDV 603
E+R L +HK K LE ++++
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQEL 1271
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 100 bits (249), Expect = 6e-21
Identities = 131/555 (23%), Positives = 256/555 (46%), Gaps = 81/555 (14%)
Query: 25 QAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREW 84
Q Q +E LQ T+ + ++A+ +L+ L++ + Q+ EE++L E+ A
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQK---HSQLTEEKNLLQEQLQAE------- 906
Query: 85 EEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDH 144
+EL EA ++R LA + +++EE+ + E RLE E D+ ++
Sbjct: 907 --------TELYAEAEEMRVRLAAKKQELEEILHEM-----EARLEEEE---DRGQQLQA 950
Query: 145 HREQYENLKWTLERKLEELDGELALQRQELLLE---FESKMRKREHEFRLQADNMSNTAL 201
R++ LE +LEE + RQ+L LE E+K++K E E + D + +
Sbjct: 951 ERKKMAQQMLDLEEQLEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 202 SREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSR- 257
R+L ++ L L +E + + E+ +ELE +L+ Q+LE + R
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 258 --ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDR-LAREKDAVLVAVKGAHVEQLQELQ 314
D +++ +Q + + +K EEL LAR D + A K +++++EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELE 1124
Query: 315 TRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRE--DASTVKSAWDAQIAQ--- 369
+ +LQ ++ A +AE ++ D +E +A +L + D++ + A+ Q
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 370 -----LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQV 424
L +E S + Q+Q ++++ + ++ + +R K L + +++LE++
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD---KNKQTLEKENA 1241
Query: 425 QLGLDWQ---RRCDDIERDQIQKSEALIQGLSMAKS---QVAAKLQETEQALQEQ----- 473
L + + + ++E + +K EA +Q L S + A+L + LQ +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 474 ----EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNT 529
E KA+ L +D A + ++ Q LL+ EE K S+++++L E+
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQ-----DTQELLQ--EETRQKLNVSTKLRQLEEERN 1353
Query: 530 SLRNAIAQMRKEMEA 544
SL++ Q+ +EMEA
Sbjct: 1354 SLQD---QLDEEMEA 1365
Score = 93.2 bits (230), Expect = 1e-18
Identities = 131/614 (21%), Positives = 268/614 (43%), Gaps = 82/614 (13%)
Query: 7 EPALNELLLRKEEEWRA---LQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQV 63
E N L + +EE A L+ H + L L D++ +L++ + L+E +
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLN-IQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 64 LEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
+E + E AA+ + + + + E+ +L ++ RQ ++ +K + Q L
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ---LL 1464
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
+E + + ++D+ + + E +L R LEE AL+ +E L E +KM
Sbjct: 1465 AEEKNISSK--YADERDRAEAEAREKETKALSLARALEE-----ALEAKEEL-ERTNKML 1516
Query: 184 KREHEFRLQA-DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKL 242
K E E + + D++ E + L ++E +K + + LQ E LE +
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 243 QSRAGELQ-DLEA---MSRARVKDLEDKLHSVQLTRKKEEE------TFKRKHE-ELDRL 291
Q+ G+ + DL+A + + + L+ +LH + + E + K+K E +L L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 292 AREKDAVLVAVKGAH--VEQLQELQTRVLELQAHCETLEA---QLRRAEWRQADTAKEKD 346
+ D+ A+KG ++QL++LQ ++ + Q E A ++ AK +
Sbjct: 1637 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 347 AAIDQLREDASTVKSAW---DAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIE 403
A + QL+ED + + A D + +L++E+ S LQ+E+ +L+A++A+ ++++E
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 404 RYK-----------------QQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSE 446
+ +QLS + ERS + +R+ ++ R ++ + E
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL-RSKLHEME 1812
Query: 447 ALIQGLSMAKSQVA---AKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQM 503
++ S KS +A AK+ + E+ ++++ +A T Q + L+ L +
Sbjct: 1813 GAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1870
Query: 504 LLRQHEEEISK------------DFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI-- 549
+ Q++E+ K + E QR+ L+ + + + EA+ ++
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 550 -------PPPIQTA 556
PPP +T+
Sbjct: 1931 LKSKLRGPPPQETS 1944
Score = 85.9 bits (211), Expect = 2e-16
Identities = 153/653 (23%), Positives = 275/653 (42%), Gaps = 107/653 (16%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQ---DTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
LN+ + + + E ++ + + A++ D S + Q LQE+ L V +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 67 -RDLELERYDAAFAQAREWEEARRAE--VSELKIEAAKLRQALAREARKVEELQQQQQLA 123
R LE ER E E + E +S L I+ + ++ L A VE L++ ++
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK-R 1403
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
FQ+ L + + +K D + E K L+++L++L +L QRQ L+ E K R
Sbjct: 1404 FQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQ-LVSNLEKKQR 1458
Query: 184 KREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
K + +LL +E K +K A+ RAEA E E K
Sbjct: 1459 KFD---------------------QLLAEE----KNISSKYADERDRAEAEAREKETK-- 1491
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
A+S AR LE+ L + +++ E T K E++ L KD V
Sbjct: 1492 ----------ALSLARA--LEEALEA----KEELERTNKMLKAEMEDLVSSKDDV----- 1530
Query: 304 GAHVEQLQE----LQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
G +V +L++ L+T++ E++ E LE +L+ E D + + L+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEVNMQALKGQFERD 1586
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAV------ 413
A D Q + +++ + + +T E+E K +A A +++ +E + L L
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 414 --ERERSLERDQVQLGLDWQRRCDD--IERDQI--------QKSEALIQGLSMAKSQVAA 461
E + L + Q Q+ D+QR +D RD+I +K+++L L + +AA
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 462 KLQETEQALQEQEVVLK--AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS 519
+ +QA E+E + + A +L A+Q + L AQ+ EE+ + + S
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSD 1764
Query: 520 EIQRLREQ-----------------NTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDA 562
+++ +Q N S R + + KE+ + H++ +++ +ST A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 563 NQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE 615
A + +A ++LK K K L++ L V D KM+ + E
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Score = 85.5 bits (210), Expect = 2e-16
Identities = 109/473 (23%), Positives = 210/473 (44%), Gaps = 34/473 (7%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
+E+E +AL R L+EA + + +LE L+ ED V + + + ELE+
Sbjct: 1486 REKETKALSLARA-LEEAL--EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 77 AFAQAREWEEARRAEVSE--LKIEAAKLRQALAREARK--VEELQQQQQLAFQEHRLELE 132
A E + + E+ + E AKLR + +A K E Q + +E R +L+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLE------ELDGELALQRQELLLEFESKMRKRE 186
R + E++ R+Q L ++KLE EL + A++ +E ++ K++ +
Sbjct: 1603 RQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 187 HEF-------RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
+F R D + TA E K K L +L L+E A A + ++A+ EL
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 240 RKLQSRAG---ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKD 296
+L S LQD + AR+ LE++L Q + + ++ ++ ++L+ E
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL- 1780
Query: 297 AVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDA 356
A + + Q+L+ + EL++ +E ++ + K A +++ E
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 357 STVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ K A + Q K++ LQ++ ++ + K Q + +++ K+QL A E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQV-AAKLQETEQ 468
+ + ++ +L QR D + + +EA+ + ++ KS++ QET Q
Sbjct: 1901 QRINANRRKL----QRELD----EATESNEAMGREVNALKSKLRGPPPQETSQ 1945
Score = 82.8 bits (203), Expect = 1e-15
Identities = 121/550 (22%), Positives = 244/550 (44%), Gaps = 59/550 (10%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L + EE R A + Q E L + ++LEE + + + LQ + + + ++ L+LE
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE----RKKMAQQMLDLEE 964
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
Q E E AR+ +L++E + + ++ + Q +E +L ER
Sbjct: 965 ------QLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 134 VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA 193
+ SD + E+ +NL L+ K E + EL E+ L+ E K R+ + + +
Sbjct: 1015 I-SDLTTNLAEEEEKAKNLT-KLKNKHESMISEL-----EVRLKKEEKSRQELEKLKRK- 1066
Query: 194 DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLE 253
+ A ++ L ++ LK AK E LQ A A L+ ++ + L+ +
Sbjct: 1067 --LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIR 1121
Query: 254 AMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQEL 313
+ + DL++ L S + R K E+ + EEL+ L E + L + QEL
Sbjct: 1122 EL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS-----TATQQEL 1175
Query: 314 QT-RVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSK 372
+ R E+ + L+ + R E + + ++ A+++L E Q+ Q +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-----------QLEQFKR 1224
Query: 373 EMVSRDLQIQTLQEEEVKLKAQ---VARSQQDIERYKQQLSLAVERERSL----ERDQVQ 425
+ D QTL++E L + + +++Q++E K++L V+ +S ER + +
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 426 LGLDWQRRCDDIERDQIQKSEALIQGLSMAK--SQVAAKLQETEQALQE---QEVVLKAV 480
L + +++E +EA + + +AK + ++++LQ+T++ LQE Q++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS--EIQRLREQNTSLRNAIAQM 538
+ ++ +L+ A+ L +H ++ S ++Q +L +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 539 RKEMEALSHQ 548
+KE+E L+ Q
Sbjct: 1405 QKEIENLTQQ 1414
Score = 58.5 bits (140), Expect = 3e-08
Identities = 93/447 (20%), Positives = 190/447 (42%), Gaps = 75/447 (16%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK--------------LQSRA---G 247
L+V +E++A ++ K E Q+AE ELE+K LQ+
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 248 ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV 307
E +++ A+ ++LE+ LH ++ ++EE+ ++ E ++A++ +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL--------E 963
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQI 367
EQL+E + +LQ T EA++++ E ++ +D S + + +I
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLE--------DEILVMDDQNNKLSKERKLLEERI 1015
Query: 368 AQLSKEMVSRDLQIQTL-----------QEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ L+ + + + + L E EV+LK + +S+Q++E+ K++L E +
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKL----EGD 1070
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVA------AKLQETEQAL 470
S +Q+ D Q + +++ +K E L L+ ++A K++E E +
Sbjct: 1071 ASDFHEQI---ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 471 QEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQN-T 529
+ + L + R++A + R G + L + E+ + E++ REQ T
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 530 SLRNAIAQMRKEMEALSHQI-PPPIQTAAESTDANQPDPEAGGDAATPDYVLA-----LE 583
L+ A+ + + EA ++ Q E T+ + A + L L
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 584 AEIRTL-------KHKFKTLEKHLEDV 603
E+R L +HK K LE ++++
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQEL 1271
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 100 bits (249), Expect = 6e-21
Identities = 131/555 (23%), Positives = 256/555 (46%), Gaps = 81/555 (14%)
Query: 25 QAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREW 84
Q Q +E LQ T+ + ++A+ +L+ L++ + Q+ EE++L E+ A
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQK---HSQLTEEKNLLQEQLQAE------- 899
Query: 85 EEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDH 144
+EL EA ++R LA + +++EE+ + E RLE E D+ ++
Sbjct: 900 --------TELYAEAEEMRVRLAAKKQELEEILHEM-----EARLEEEE---DRGQQLQA 943
Query: 145 HREQYENLKWTLERKLEELDGELALQRQELLLE---FESKMRKREHEFRLQADNMSNTAL 201
R++ LE +LEE + RQ+L LE E+K++K E E + D + +
Sbjct: 944 ERKKMAQQMLDLEEQLEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 202 SREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSR- 257
R+L ++ L L +E + + E+ +ELE +L+ Q+LE + R
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 258 --ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDR-LAREKDAVLVAVKGAHVEQLQELQ 314
D +++ +Q + + +K EEL LAR D + A K +++++EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELE 1117
Query: 315 TRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRE--DASTVKSAWDAQIAQ--- 369
+ +LQ ++ A +AE ++ D +E +A +L + D++ + A+ Q
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 370 -----LSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQV 424
L +E S + Q+Q ++++ + ++ + +R K L + +++LE++
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD---KNKQTLEKENA 1234
Query: 425 QLGLDWQ---RRCDDIERDQIQKSEALIQGLSMAKS---QVAAKLQETEQALQEQ----- 473
L + + + ++E + +K EA +Q L S + A+L + LQ +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 474 ----EVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNT 529
E KA+ L +D A + ++ Q LL+ EE K S+++++L E+
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQ-----DTQELLQ--EETRQKLNVSTKLRQLEEERN 1346
Query: 530 SLRNAIAQMRKEMEA 544
SL++ Q+ +EMEA
Sbjct: 1347 SLQD---QLDEEMEA 1358
Score = 93.2 bits (230), Expect = 1e-18
Identities = 131/614 (21%), Positives = 268/614 (43%), Gaps = 82/614 (13%)
Query: 7 EPALNELLLRKEEEWRA---LQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQV 63
E N L + +EE A L+ H + L L D++ +L++ + L+E +
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLN-IQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 64 LEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
+E + E AA+ + + + + E+ +L ++ RQ ++ +K + Q L
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ---LL 1457
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
+E + + ++D+ + + E +L R LEE AL+ +E L E +KM
Sbjct: 1458 AEEKNISSK--YADERDRAEAEAREKETKALSLARALEE-----ALEAKEEL-ERTNKML 1509
Query: 184 KREHEFRLQA-DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKL 242
K E E + + D++ E + L ++E +K + + LQ E LE +
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 243 QSRAGELQ-DLEA---MSRARVKDLEDKLHSVQLTRKKEEE------TFKRKHE-ELDRL 291
Q+ G+ + DL+A + + + L+ +LH + + E + K+K E +L L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 292 AREKDAVLVAVKGAH--VEQLQELQTRVLELQAHCETLEA---QLRRAEWRQADTAKEKD 346
+ D+ A+KG ++QL++LQ ++ + Q E A ++ AK +
Sbjct: 1630 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 347 AAIDQLREDASTVKSAW---DAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIE 403
A + QL+ED + + A D + +L++E+ S LQ+E+ +L+A++A+ ++++E
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 404 RYK-----------------QQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSE 446
+ +QLS + ERS + +R+ ++ R ++ + E
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL-RSKLHEME 1805
Query: 447 ALIQGLSMAKSQVA---AKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQM 503
++ S KS +A AK+ + E+ ++++ +A T Q + L+ L +
Sbjct: 1806 GAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1863
Query: 504 LLRQHEEEISK------------DFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI-- 549
+ Q++E+ K + E QR+ L+ + + + EA+ ++
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 550 -------PPPIQTA 556
PPP +T+
Sbjct: 1924 LKSKLRGPPPQETS 1937
Score = 85.9 bits (211), Expect = 2e-16
Identities = 153/653 (23%), Positives = 275/653 (42%), Gaps = 107/653 (16%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQ---DTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
LN+ + + + E ++ + + A++ D S + Q LQE+ L V +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 67 -RDLELERYDAAFAQAREWEEARRAE--VSELKIEAAKLRQALAREARKVEELQQQQQLA 123
R LE ER E E + E +S L I+ + ++ L A VE L++ ++
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK-R 1396
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMR 183
FQ+ L + + +K D + E K L+++L++L +L QRQ L+ E K R
Sbjct: 1397 FQKEIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQ-LVSNLEKKQR 1451
Query: 184 KREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
K + +LL +E K +K A+ RAEA E E K
Sbjct: 1452 KFD---------------------QLLAEE----KNISSKYADERDRAEAEAREKETK-- 1484
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
A+S AR LE+ L + +++ E T K E++ L KD V
Sbjct: 1485 ----------ALSLARA--LEEALEA----KEELERTNKMLKAEMEDLVSSKDDV----- 1523
Query: 304 GAHVEQLQE----LQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
G +V +L++ L+T++ E++ E LE +L+ E D + + L+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEVNMQALKGQFERD 1579
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAV------ 413
A D Q + +++ + + +T E+E K +A A +++ +E + L L
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 414 --ERERSLERDQVQLGLDWQRRCDD--IERDQI--------QKSEALIQGLSMAKSQVAA 461
E + L + Q Q+ D+QR +D RD+I +K+++L L + +AA
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 462 KLQETEQALQEQEVVLK--AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS 519
+ +QA E+E + + A +L A+Q + L AQ+ EE+ + + S
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSD 1757
Query: 520 EIQRLREQ-----------------NTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDA 562
+++ +Q N S R + + KE+ + H++ +++ +ST A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 563 NQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE 615
A + +A ++LK K K L++ L V D KM+ + E
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Score = 85.5 bits (210), Expect = 2e-16
Identities = 109/473 (23%), Positives = 210/473 (44%), Gaps = 34/473 (7%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
+E+E +AL R L+EA + + +LE L+ ED V + + + ELE+
Sbjct: 1479 REKETKALSLARA-LEEAL--EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 77 AFAQAREWEEARRAEVSE--LKIEAAKLRQALAREARK--VEELQQQQQLAFQEHRLELE 132
A E + + E+ + E AKLR + +A K E Q + +E R +L+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLE------ELDGELALQRQELLLEFESKMRKRE 186
R + E++ R+Q L ++KLE EL + A++ +E ++ K++ +
Sbjct: 1596 RQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 187 HEF-------RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
+F R D + TA E K K L +L L+E A A + ++A+ EL
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 240 RKLQSRAG---ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKD 296
+L S LQD + AR+ LE++L Q + + ++ ++ ++L+ E
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL- 1773
Query: 297 AVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDA 356
A + + Q+L+ + EL++ +E ++ + K A +++ E
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 357 STVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ K A + Q K++ LQ++ ++ + K Q + +++ K+QL A E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQV-AAKLQETEQ 468
+ + ++ +L QR D + + +EA+ + ++ KS++ QET Q
Sbjct: 1894 QRINANRRKL----QRELD----EATESNEAMGREVNALKSKLRGPPPQETSQ 1938
Score = 82.8 bits (203), Expect = 1e-15
Identities = 121/550 (22%), Positives = 244/550 (44%), Gaps = 59/550 (10%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L + EE R A + Q E L + ++LEE + + + LQ + + + ++ L+LE
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE----RKKMAQQMLDLEE 957
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
Q E E AR+ +L++E + + ++ + Q +E +L ER
Sbjct: 958 ------QLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 134 VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA 193
+ SD + E+ +NL L+ K E + EL E+ L+ E K R+ + + +
Sbjct: 1008 I-SDLTTNLAEEEEKAKNLT-KLKNKHESMISEL-----EVRLKKEEKSRQELEKLKRK- 1059
Query: 194 DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLE 253
+ A ++ L ++ LK AK E LQ A A L+ ++ + L+ +
Sbjct: 1060 --LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIR 1114
Query: 254 AMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQEL 313
+ + DL++ L S + R K E+ + EEL+ L E + L + QEL
Sbjct: 1115 EL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS-----TATQQEL 1168
Query: 314 QT-RVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSK 372
+ R E+ + L+ + R E + + ++ A+++L E Q+ Q +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-----------QLEQFKR 1217
Query: 373 EMVSRDLQIQTLQEEEVKLKAQ---VARSQQDIERYKQQLSLAVERERSL----ERDQVQ 425
+ D QTL++E L + + +++Q++E K++L V+ +S ER + +
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 426 LGLDWQRRCDDIERDQIQKSEALIQGLSMAK--SQVAAKLQETEQALQE---QEVVLKAV 480
L + +++E +EA + + +AK + ++++LQ+T++ LQE Q++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSS--EIQRLREQNTSLRNAIAQM 538
+ ++ +L+ A+ L +H ++ S ++Q +L +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 539 RKEMEALSHQ 548
+KE+E L+ Q
Sbjct: 1398 QKEIENLTQQ 1407
Score = 58.5 bits (140), Expect = 3e-08
Identities = 93/447 (20%), Positives = 190/447 (42%), Gaps = 75/447 (16%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK--------------LQSRA---G 247
L+V +E++A ++ K E Q+AE ELE+K LQ+
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 248 ELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV 307
E +++ A+ ++LE+ LH ++ ++EE+ ++ E ++A++ +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL--------E 956
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQI 367
EQL+E + +LQ T EA++++ E ++ +D S + + +I
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLE--------DEILVMDDQNNKLSKERKLLEERI 1008
Query: 368 AQLSKEMVSRDLQIQTL-----------QEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
+ L+ + + + + L E EV+LK + +S+Q++E+ K++L E +
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKL----EGD 1063
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVA------AKLQETEQAL 470
S +Q+ D Q + +++ +K E L L+ ++A K++E E +
Sbjct: 1064 ASDFHEQI---ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 471 QEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQN-T 529
+ + L + R++A + R G + L + E+ + E++ REQ T
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLG---EELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 530 SLRNAIAQMRKEMEALSHQI-PPPIQTAAESTDANQPDPEAGGDAATPDYVLA-----LE 583
L+ A+ + + EA ++ Q E T+ + A + L L
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 584 AEIRTL-------KHKFKTLEKHLEDV 603
E+R L +HK K LE ++++
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQEL 1264
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 99.8 bits (247), Expect = 1e-20
Identities = 187/786 (23%), Positives = 338/786 (43%), Gaps = 131/786 (16%)
Query: 27 HRTQLQEAALQDTRSQLEEAQ---GKLRCLQEDFVYNLQVLEERDLELERYDAAFAQARE 83
H+ QLQ +QD R + E +Q G LR D + LEE +L+R A +
Sbjct: 529 HKRQLQ---VQDMRGRYEASQDLLGTLRKQLSDSESERRALEE---QLQRLRDKTDGAMQ 582
Query: 84 WEEARRAEVSELKI-------EAAKLRQALAREARKVEELQQQQ---QLAFQEHRLELER 133
E + EV L+ E + L +L ++ EEL+Q++ Q A +E R + +R
Sbjct: 583 AHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDR 642
Query: 134 VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA 193
+ ++ + L+ + R+LE+L+G+ ++ +EL+ E R
Sbjct: 643 LEEEQEDAVQDGARVRRELERS-HRQLEQLEGKRSVLAKELV------------EVR--- 686
Query: 194 DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE---RKLQSRAGELQ 250
+ +S L R++ L+ A+ AE+L +AEA ELE KL++ LQ
Sbjct: 687 EALSRATLQRDM-----------LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ 735
Query: 251 D-LEAMSRARVKDLEDKLHSVQLTRKKEEETF-----KRKHEELDRLAREKDAVLVAVKG 304
D L +S +DKL +L + EEE +R+ E+ +ARE+
Sbjct: 736 DSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ-------- 787
Query: 305 AHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWD 364
E+L+EL+ LE + + LE LR AE QA A E+ + LR + S ++
Sbjct: 788 ---ERLEELR---LEQEVARQGLEGSLRVAE--QAQEALEQQ--LPTLRHERSQLQE--- 834
Query: 365 AQIAQLSKEMVSRDLQIQTLQEE---EVKLKAQVARSQQDIERYKQQLS---LAVERE-R 417
Q+AQLS+++ R+ +++ + E +V+ + AR ++ + + L+ +A ERE R
Sbjct: 835 -QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
Query: 418 SLERDQVQLGL----------DWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQE-T 466
+L + +L L + QR+ +E + ++ EA Q L +AK + +L
Sbjct: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR-EQLEAEGQALLLAKETLTGELAGLR 952
Query: 467 EQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQ----HEEEISKDFPSSEIQ 522
+Q + QE L + VQA R AQ LR+ HEE++ + +
Sbjct: 953 QQIIATQEKASLDKELMAQKLVQAER-------EAQASLREQRAAHEEDLQR-LQREKEA 1004
Query: 523 RLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLAL 582
RE +Q+++E E L ++ + +E A Q + + G +L
Sbjct: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEG--------LLLA 1056
Query: 583 EAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQA 642
E+E K + +L++ + L M + H+ + S+ + ++ Q +V A
Sbjct: 1057 ESE----KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA 1112
Query: 643 -----GQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPR 697
+ + +R+L ++ + L + R LRE E R L
Sbjct: 1113 LTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG----KQRDSCLREAEELRTQLRLLED 1168
Query: 698 EVDQVHLEVLELRKQVAEL--GKHLRIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDE 755
D + E+LE ++++ E G+ ++ + G S + +A+ E+ +SA +
Sbjct: 1169 ARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKK 1228
Query: 756 APSRHL 761
A S +
Sbjct: 1229 AESERI 1234
Score = 96.7 bits (239), Expect = 9e-20
Identities = 197/839 (23%), Positives = 355/839 (42%), Gaps = 125/839 (14%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQD----------TRSQLEEAQGKLRCLQEDFVYNL 61
E L +EE R + + QE A+QD + QLE+ +GK L ++ V
Sbjct: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQ 121
+ L L+ + A A+ E A EL++ KLR A EA + L +
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR---AEEASLQDSLSKLSA 743
Query: 122 L--AFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQEL----L 175
L + + +L+L R+ + Q E K L+ + + + E + R+E
Sbjct: 744 LNESLAQDKLDLNRLVA-----------QLEEEKSALQGRQRQAEQEATVAREEQERLEE 792
Query: 176 LEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATN 235
L E ++ ++ E L+ + AL ++L L E L+E A+ + L E
Sbjct: 793 LRLEQEVARQGLEGSLRVAEQAQEALEQQLPT--LRHERSQLQEQLAQLSRQLSGRE--- 847
Query: 236 AELERKLQSRAGELQDLEAMSR-ARVKDLEDKLH---SVQLTRKKEEETFKRKHEELDRL 291
ELE Q+R + +EA+ R AR K+ K H +VQL + E + EE RL
Sbjct: 848 QELE---QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG--RTLSEEATRL 902
Query: 292 AREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEK-DAAID 350
EK+ A++G+ L E+Q ++ +L+A E LE AE + AKE +
Sbjct: 903 RLEKE----ALEGS----LFEVQRQLAQLEARREQLE-----AEGQALLLAKETLTGELA 949
Query: 351 QLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLS 410
LR+ + + A L KE++++ L +Q +E + L+ Q A ++D++R +++
Sbjct: 950 GLRQQIIATQ-----EKASLDKELMAQKL-VQAEREAQASLREQRAAHEEDLQRLQREKE 1003
Query: 411 LAVERERSLERDQVQLGLDWQRRCDDI------ERDQIQKSEALIQ-----GLSMAKS-- 457
A R LE ++ QL QR +++ E++++ + A +Q GL +A+S
Sbjct: 1004 AA---WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
Query: 458 QVAAKLQETEQALQEQEVV-----LKAVTLERD-QAVQALRMHGLPRPGAQML------L 505
Q A L+E+E+ ++++ L ++LE + Q A R L L
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120
Query: 506 RQHEEEISKDFPSSEIQRLREQ--------------NTSLRNAIAQMRKEMEALSHQIPP 551
R EE + + E++RL+EQ LR + + + L ++
Sbjct: 1121 RAQREEAAAAH-AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
Query: 552 PIQTAAESTDANQPDPEAGGDAATPDYVLALEAE-IRTLKHKFKTLEKHLEDVLDPLKMS 610
+ ES + + + G+ A E E +R + ++ K E LK++
Sbjct: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
Query: 611 SPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLL 670
+ E + ++ T G +AG+ +Q V+ + + L++L ++++L
Sbjct: 1240 NEDKEQKLALLEEARTAVGK-EAGELRTGLQ------EVERSRLEARRELQELRRQMKML 1292
Query: 671 NLLVTRLRQKVLREPLEPAAL----QRELPREVDQVHLEVLELRKQVAELGKHLRIAQHG 726
+ TRL ++ L E AL ++E RE + +L+ + + + L++AQ
Sbjct: 1293 DSENTRLGRE-LAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK 1351
Query: 727 GAEPSGR---KQPPASDAVALGREDAKSAEDEAPSRHLGKHQPR--SAQVGSRLDALQG 780
E G ++ ++ R K D A L R +A++G RL A +G
Sbjct: 1352 LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
Score = 84.0 bits (206), Expect = 6e-16
Identities = 135/577 (23%), Positives = 252/577 (43%), Gaps = 58/577 (10%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAA--LQDTRSQLEEAQGKLRCLQEDFVYNLQVLEER 67
LN L+ + EEE ALQ + Q ++ A ++ + +LEE + + ++ +L+V E+
Sbjct: 755 LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQA 814
Query: 68 DLELE-----------RYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL 116
LE + AQ R E+ + + EA + +AL R AR+ E L
Sbjct: 815 QEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL 874
Query: 117 QQQQQ-LAFQEHRLELE-RVHSDKNGEIDHHREQYENLKWTLERKLEELDG---ELALQR 171
++ LA Q E E R S++ + +E E + ++R+L +L+ +L +
Sbjct: 875 AKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG 934
Query: 172 QELLLEFESKMRKREHEFRLQADNMSNTALSRELKV-KLLHKELEA---LKEAGAKAAES 227
Q LLL E+ + + +L +EL KL+ E EA L+E A E
Sbjct: 935 QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEED 994
Query: 228 LQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEE 287
LQR L+R+ ++ EL+ A +++++ +++L +L +KEE + EE
Sbjct: 995 LQR-------LQREKEAAWRELEAERAQLQSQLQREQEEL-LARLEAEKEELS-----EE 1041
Query: 288 LDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDA 347
+ L +E+D L+ A E+ Q L + E A E L + ++K
Sbjct: 1042 IAALQQERDEGLLL---AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRD 1098
Query: 348 AIDQLREDASTVKSAWDAQI----AQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIE 403
A + +D STV +A +++ AQ + + +++ LQE+ L Q ++ E
Sbjct: 1099 AQSRQEQDRSTV-NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAE 1157
Query: 404 RYKQQLSLAVERERSLERDQVQLGLDWQRRC-DDIERDQIQKSEA--LIQGLSMAKSQVA 460
+ QL L + L R+ L+ QR+ + E ++Q+ EA L + L +
Sbjct: 1158 ELRTQLRLLEDARDGLRREL----LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
Query: 461 A------KLQETEQALQEQEVVLKAVTLERDQAVQALR--MHGLPRPGAQMLLRQHEEEI 512
A +L+ + + + + LK +++Q + L + + ++ E E
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 513 SKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549
S+ E+Q LR Q L + ++ +E+ L ++
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRL 1310
Score = 82.0 bits (201), Expect = 2e-15
Identities = 170/820 (20%), Positives = 327/820 (39%), Gaps = 94/820 (11%)
Query: 58 VYNLQVLEERDL-----ELERYDAAFAQA--------REWEEARRAEVSELKIEAAKLRQ 104
V +++ ERDL EL R A +A R E A + + + A+L +
Sbjct: 310 VSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEE 369
Query: 105 ALAREARKVEELQQQQ---------------QLAFQEHRLELERVHSDK-NGEIDHHREQ 148
L + + ++L QQQ +L RLE + + D+ N ++ E
Sbjct: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
Query: 149 YENLKWTLERKLEELDGELALQR-----QELLLEFESKMRKREHEFRLQADNMSNTALSR 203
E+L+ + LE DGE Q Q +L + ES ++ E A N S LS
Sbjct: 430 LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
Query: 204 ELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ + + + +T A + L R ++QD+ R R +
Sbjct: 490 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM----RGRYEAS 545
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAH 323
+D L +++ E + E+L RL + D + A + A E +Q L++ L
Sbjct: 546 QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE-VQRLRSANELLSRE 604
Query: 324 CETLEAQLRRAEWRQADTAKEKD---AAIDQLREDASTVKSAWDAQI---AQLSKEMVSR 377
L L+ A+ + + +E++ AA ++LR ++ + + A++ +E+
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS 664
Query: 378 DLQIQTLQ-------EEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDW 430
Q++ L+ +E V+++ ++R+ + + + + E E +V+L L
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 431 QR-RCDDIE-RDQIQKSEALIQGLSMAK---SQVAAKLQETEQALQ------EQEVVLKA 479
+ R ++ +D + K AL + L+ K +++ A+L+E + ALQ EQE
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT--- 781
Query: 480 VTLERDQAVQALRMHG-LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
V E + ++ LR+ + R G + LR E+ +++ ++ LR + + L+ +AQ+
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQ--AQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 539 RKEMEALSHQIPPPIQTAAESTDA-----NQPDPEAGGDAATPDYVLALEAEIRTLKHKF 593
+++ ++ + A +A + + A A ++A E E RTL +
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 594 KTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGS------AQAGQAGGSVQAGQAGG 647
L E + L + R E G + G+ G Q Q
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ--QIIA 957
Query: 648 SVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVL 707
+ + + L +KL + R Q LRE + AA + +L R +
Sbjct: 958 TQEKASLDKELMAQKL--------VQAEREAQASLRE--QRAAHEEDLQRLQREKEAAWR 1007
Query: 708 ELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPR 767
EL + A+L L+ Q ++ S+ +A +++ A S +
Sbjct: 1008 ELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLK 1067
Query: 768 SAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQ 807
++ + + L G T+HS+ T++ + RQK D + Q
Sbjct: 1068 ESEKTALSEKLMG--TRHSLATISLEMERQKRDAQSRQEQ 1105
Score = 78.2 bits (191), Expect = 3e-14
Identities = 193/862 (22%), Positives = 338/862 (39%), Gaps = 109/862 (12%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL-E 65
E L L KE WR L+A R QLQ + + EE +L +E+ + L +
Sbjct: 992 EEDLQRLQREKEAAWRELEAERAQLQ----SQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Query: 66 ERDLELERYDAAFAQAREWEEARRAEVSE----LKIEAAKLRQALAREARKVEELQQQQQ 121
ERD L ++ QA +E+ + +SE + A + + R+ R + Q+Q +
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
Query: 122 LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESK 181
EL + + + H ++ R+L+E +L QR L E E
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEV--------RRLQEQARDLGKQRDSCLREAE-- 1157
Query: 182 MRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKE-AGAKAAESLQRAEATNAELER 240
+ + RL D + L REL LEA ++ ++ +QR EA EL R
Sbjct: 1158 --ELRTQLRLLED--ARDGLRREL--------LEAQRKLRESQEGREVQRQEA--GELRR 1203
Query: 241 KLQSRAGELQDLEAMS---RARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA 297
L A E + L + R+ VK E + S++L + +E+ E + +E
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 298 V---LVAVKGAHVE---QLQELQTRVLELQAHCETLEAQLRRAEWRQA-DTAKEKDAAID 350
+ L V+ + +E +LQEL+ ++ L + L +L + R A EK++ +
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 351 QLREDASTVKSAWDAQIAQLSKEMVSRDLQI--QTLQEEEVKLKAQVARSQQDIER---- 404
L +K + S E++ ++LQ+ + LQE+E + + + R +E
Sbjct: 1324 TLGLRQRLLK-------GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGT 1376
Query: 405 YKQQLSLAVERERSLE---RDQVQLGL-------------------DWQRRCDDIE---- 438
KQQL A E LE + +LGL + QRR + +
Sbjct: 1377 EKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL 1436
Query: 439 RDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPR 498
R +++ L + S A V A E + TLE Q
Sbjct: 1437 RSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
Query: 499 PGAQML----LRQHEEEISKDFPSSEIQR--LREQNTSLRNAIAQMRKEMEALSHQIPPP 552
P + L +R E ++ S++ +R LR Q ++L +A+M E ++ + +
Sbjct: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
Query: 553 IQTAAESTDANQP-DPEAGGD----AATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPL 607
+ AES +A + D G A + V E E R + TLE+ L+ L
Sbjct: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Query: 608 KMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLG--D 665
+ S + T E G + + + ++ +Q + L +LG D
Sbjct: 1617 RASQEKISKMKANETKLE--GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 666 R---VQLLNLLVTRLRQKVLREPLEPAALQRELPR---EVDQVHLEVLELRKQVAELGKH 719
R Q L V L+++V ++ LQ + R + +V LR +V L +
Sbjct: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEA 1734
Query: 720 LRIAQHGGAEPSGR-KQPPASDAVALGREDAKSAED--EAPSRHLGKHQPRSAQVGSRLD 776
L AQ + S R K A+ D + ++ +A + L + + +S+ +G ++
Sbjct: 1735 L--AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 777 ALQGPKTQHSIHTVTCKSPRQK 798
L+G + V + Q+
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQ 1814
Score = 63.2 bits (152), Expect = 1e-09
Identities = 156/747 (20%), Positives = 295/747 (39%), Gaps = 93/747 (12%)
Query: 28 RTQLQEAALQ--DTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWE 85
RT LQE + R +L+E + +++ L + + L E L + A ++R
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
Query: 86 EARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRL--ELERVHSDKNGEID 143
R + + + +RQ L RK++E Q+ + +E RL LE + ++D
Sbjct: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQE--QEGEFRTRERRLLGSLEEARGTEKQQLD 1382
Query: 144 HHREQYENLKWTLERKLEELDGELALQRQELLLE------FESKMRKREHEFRLQADNMS 197
H R LE KLE E A L E+++ + E + R +
Sbjct: 1383 HARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLG 1434
Query: 198 N--TALSRELKVKLLHKEL----------EALKEA---GAKAAESLQRAEATNAELERKL 242
+AL R L + +A E G + +L+ + +
Sbjct: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
Query: 243 QSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAV 302
S A D EA+ R +++ +L S Q R + + +L + E+D+
Sbjct: 1495 TSPASPDLDPEAV-RGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSA---- 1549
Query: 303 KGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSA 362
+ ++LQ V E + +++ +L QA+ A ++++ RE +T+
Sbjct: 1550 ----TSRARQLQKAVAESEEARRSVDGRLSGV---QAELALQEESVRRSERERRATLD-- 1600
Query: 363 WDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVER------- 415
Q+A L + + + + +++ QE+ K+KA + + D R K+ L + R
Sbjct: 1601 ---QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQ 1657
Query: 416 ERSLERD--QVQLGLD--------WQRRCDDIERDQIQKSEALIQGLSMAKSQV---AAK 462
RSLE + + +LGL Q R D ++R Q+ SE L + ++ AK
Sbjct: 1658 RRSLEGELQRSRLGLSDREAQAQALQDRVDSLQR-QVADSEVKAGTLQLTVERLNGALAK 1716
Query: 463 LQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISK---DFPSS 519
++E+E AL+++ L + ++ + R L A + +H+ ++ + D
Sbjct: 1717 VEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-LTACEHDRQVLQERLDAARQ 1775
Query: 520 EIQRLREQNTSLRNAIAQMRKEMEALSHQ---IPPPIQTAAESTDANQPDPEAGGDAATP 576
+ R+Q++SL + +R E+ L Q +Q E Q G+AA
Sbjct: 1776 ALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE-----GEAAAL 1830
Query: 577 DYVLALEAEIRTLKHKFKTLEK---HLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQA 633
+ V L+ E R L+ + +L++ LE ++ S+ E T +
Sbjct: 1831 NTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKL 1890
Query: 634 GQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR 693
+V+ G + + L L + ++Q L V VL + PA L+
Sbjct: 1891 RSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV-----VLEQSHSPAQLEV 1945
Query: 694 ELPREVDQVHLEVLELRKQVAELGKHL 720
+ ++ ++ EV LR A+ + L
Sbjct: 1946 DAQQQQLELQQEVERLRSAQAQTERTL 1972
Score = 57.8 bits (138), Expect = 5e-08
Identities = 143/684 (20%), Positives = 262/684 (38%), Gaps = 118/684 (17%)
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGE 166
A E + LQ++ QL Q+ +E + + E D +Y + LE+ L GE
Sbjct: 70 ATEMASLLSLQEENQL-LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGE 128
Query: 167 LALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAE 226
L Q L+ ++R++ LQ + S ++L+A +E + A+
Sbjct: 129 LETQEPRGLVRQSVELRRQ-----LQEEQAS------------YRRKLQAYQEGQQRQAQ 171
Query: 227 SLQRAEATN-------AELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEE 279
+QR + +ELE++L R+GEL+ +DLE L R +EE+
Sbjct: 172 LVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLES-----ALIRLEEEQ 226
Query: 280 TFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAE---- 335
+++ + RE+ + A E ++++ + E EA RR E
Sbjct: 227 QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN 286
Query: 336 -------------WRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQ 382
WRQ + R S VK + + QL E+ +Q
Sbjct: 287 AYFSNEHSRLLLLWRQ----------VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQ 336
Query: 383 T--------LQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRC 434
L+ E + +A + + + ++QL V RE+ L + Q+Q LD +
Sbjct: 337 EAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD---KA 393
Query: 435 DDIER-DQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRM 493
D R ++ + ++ ++ K QV L E +AL+ ++ L+ A++
Sbjct: 394 DLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALE-------SLRLQEQAALETEDG 446
Query: 494 HGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPI 553
GL Q LR + + D S E+ N + LS Q P
Sbjct: 447 EGL-----QQTLRDLAQAVLSDSESGVQLSGSERTADASNG------SLRGLSGQRTP-- 493
Query: 554 QTAAESTDANQPDPEAGGDAATPD-YVLAL--------EAEIRTLKHKFKTLEKHLEDVL 604
S+ P G A D LAL + +++ ++ +++ +D+L
Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA----SQDLL 549
Query: 605 DPLKMSSPHAES-----QPSVRTSTETTGGSAQAGQ-AGGSVQAGQAGGSVQAGPVSSGL 658
L+ +ES + ++ + T G+ QA + A VQ ++ + + S+
Sbjct: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN-- 607
Query: 659 ALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGK 718
L +Q+ LRQ+ RE L+ A Q EL R+ D++ E + + A + +
Sbjct: 608 ----LAHSLQVAQQQAEELRQE--REKLQ--AAQEELRRQRDRLEEEQEDAVQDGARVRR 659
Query: 719 HLRIAQHGGAEPSGRKQPPASDAV 742
L + + G++ A + V
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELV 683
Score = 52.0 bits (123), Expect = 3e-06
Identities = 157/815 (19%), Positives = 309/815 (37%), Gaps = 118/815 (14%)
Query: 38 DTRSQLEEAQG----KLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVS 93
+ R QL+E Q KL+ QE Q+++ ++ +Y ++ + R E+
Sbjct: 143 ELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE 202
Query: 94 ELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHH-------- 145
+ ++ + Q L ++EE QQ+ Q + + E++ D+ G +
Sbjct: 203 QQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL--DQAGSANQALSEDIRKV 260
Query: 146 -------REQYENLKWTLERKLEELDGELALQRQELLLEF-----------ESKMRKREH 187
R++ E+ + R+ E + + + LLL + E KM
Sbjct: 261 TNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
Query: 188 EFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAG 247
+L + + +E + L L+ A ++A +L++ A+LE +L+ +
Sbjct: 321 LLQLGGELARTSRAVQEAGLGL----STGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
Query: 248 ELQDL----------EAMSRARVKDL---EDKLHSVQLTRKKEEETFKRKHEELDRLARE 294
+DL +A ARV +L +L L + + + K E L+ L +
Sbjct: 377 REKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436
Query: 295 KDAVLVAVKGAHVEQ-LQELQTRVLELQAHCETLEAQLRRAE-----------WRQADTA 342
+ A L G ++Q L++L VL L R A+ R
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPP 496
Query: 343 KEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDI 402
+ + + + + +A + + R LQ+Q ++ + SQ +
Sbjct: 497 RRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ-------DMRGRYEASQDLL 549
Query: 403 ERYKQQLSLAVERERSLERDQVQL--GLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVA 460
++QLS + R+LE +L D + + + ++Q+ + + LS KS +A
Sbjct: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLA 609
Query: 461 AKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFP--S 518
LQ +Q +E L+ + A + LR + L + +E+ +D
Sbjct: 610 HSLQVAQQQAEE----LRQEREKLQAAQEELRRQ-------RDRLEEEQEDAVQDGARVR 658
Query: 519 SEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDY 578
E++R Q L + + KE+ ++ + A D Q + +A T
Sbjct: 659 RELERSHRQLEQLEGKRSVLAKELV----EVREALSRATLQRDMLQAEKAEVAEALTKAE 714
Query: 579 VLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGG 638
+E E+ K + E L+D L L A ++ + + AQ +
Sbjct: 715 AGRVELELSMT--KLRAEEASLQDSLSKLS-----ALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 639 SVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPA--------- 689
++Q Q +A R+ +R++ L RL Q+V R+ LE +
Sbjct: 768 ALQGRQRQAEQEA------TVAREEQERLEEL-----RLEQEVARQGLEGSLRVAEQAQE 816
Query: 690 ALQRELP---REVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGR 746
AL+++LP E Q+ ++ +L +Q++ + L A+ + A + AL +
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 747 EDAKSAEDEAPSRHLGKHQPRSA-QVGSRLDALQG 780
E A A + G+ A ++ +AL+G
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEG 911
Score = 50.1 bits (118), Expect = 1e-05
Identities = 71/289 (24%), Positives = 130/289 (44%), Gaps = 31/289 (10%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFV---YNLQVLEE 66
LN L + EE AL+ L EA Q + S L + K LQ+ ++ QVL+E
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSAS-LNSTRDKNLHLQKALTACEHDRQVLQE 1768
Query: 67 RDLELERYDAAFAQAR-------EWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQ 119
R L+ A ++AR E + R EV++L+++ + L + + + Q+
Sbjct: 1769 R---LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEG 1825
Query: 120 QQLAFQE-HRLELER-VHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLE 177
+ A +L+ ER + ++ G + Q E K +ER L+ + R+ L
Sbjct: 1826 EAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1885
Query: 178 FESKMRKREHEFRLQAD--NMSNTALSREL-------KVKLLHKELEALKEAGAKA---A 225
K+R E RL A+ + T EL +++ L ++ L+++ + A
Sbjct: 1886 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1945
Query: 226 ESLQRAEATNAELERKLQSRAGELQDLEAMSRA---RVKDLEDKLHSVQ 271
++ Q+ E+ER ++A + LEA RA RV+ LE+++ +++
Sbjct: 1946 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
Score = 31.6 bits (70), Expect = 3.5
Identities = 48/185 (25%), Positives = 78/185 (42%), Gaps = 23/185 (12%)
Query: 5 GSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL 64
G ALN + + ++E R LQ LQ A Q + E + LR L++D V + L
Sbjct: 1825 GEAAALNTVQ-KLQDERRLLQERLGSLQRALAQLEAEKREVERSALR-LEKDRVALRRTL 1882
Query: 65 E--ERD------------LELERYDAAFAQAR-EWEEARRAEVSELKIEAAKLRQALARE 109
+ ER+ E R D A E EA+R ++ +L+ + L Q+ +
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQR-QIQQLEAQVVVLEQSHSPA 1941
Query: 110 ARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL 169
+V+ QQQQL Q+ L + ++ + LE ++ L G+L
Sbjct: 1942 QLEVDA--QQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL-- 1997
Query: 170 QRQEL 174
+QEL
Sbjct: 1998 -QQEL 2001
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 98.2 bits (243), Expect = 3e-20
Identities = 148/728 (20%), Positives = 300/728 (41%), Gaps = 113/728 (15%)
Query: 18 EEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER---- 73
EE L ++ QL EA +++ +LE+ + + + + LE+ EL++
Sbjct: 904 EERCDQLIKNKIQL-EAKVKEMNERLEDEEE----MNAELTAKKRKLEDECSELKKDIDD 958
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELER 133
+ A+ + + A +V L E A L + +A+ ++ + LQ+ Q A + ++E ++
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 134 VHS---------DKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELL------LEF 178
V+S + +++ EQ + ++ LER +L+G+L L ++ ++ L+
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 179 ESKMRKREHEFRLQADNMSN---TALSRELKVKLLHKELEALKEAGAKAAESLQRAEATN 235
E K++K+E + Q + + AL + K+K +E L+E + + E
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 236 AELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREK 295
++L R+L+ + L++ + +++ KK E F++ +L+ +
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIE-----------MNKKREAEFQKMRRDLEEATLQH 1187
Query: 296 DAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLRED 355
+A A++ H + + EL ++ LQ + LE + + D + I
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK----- 1242
Query: 356 ASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVER 415
A+ + E VSR L+ Q E VKL+ + RS D + +L
Sbjct: 1243 ------------AKANLEKVSRTLEDQA-NEYRVKLE-EAQRSLNDFTTQRAKL------ 1282
Query: 416 ERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEV 475
Q ++ R Q+++ EALI L+ K ++++ ++ L+E+
Sbjct: 1283 ---------------QTENGELAR-QLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 476 VLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAI 535
A+ A+Q+ R +L Q+EEE +E+QR+ + S +
Sbjct: 1327 AKNALA----HALQS------ARHDCDLLREQYEEETE---AKAELQRVLSKANS---EV 1370
Query: 536 AQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKT 595
AQ R + E + Q ++ A + D E + V A+ A+ +L+
Sbjct: 1371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE--------EAVEAVNAKCSSLEKTKHR 1422
Query: 596 LEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVS 655
L+ +ED++ ++ S+ A + + + + A+ Q Q+ +A +S
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKI--LAEWKQKYEESQSELESSQKEARSLS 1480
Query: 656 SGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQ--------RELPREVDQVHLEVL 707
+ L K L +L + K L+E + Q EL + Q+ +E L
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKL 1540
Query: 708 ELRKQVAE 715
EL+ + E
Sbjct: 1541 ELQSALEE 1548
Score = 86.7 bits (213), Expect = 9e-17
Identities = 162/716 (22%), Positives = 293/716 (40%), Gaps = 97/716 (13%)
Query: 33 EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY----DAAFAQAREWEEAR 88
E + R +LEEAQ L DF L+ + EL R +A +Q + +
Sbjct: 1255 EDQANEYRVKLEEAQRSLN----DFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
Query: 89 RAEVSELKI---EAAKLRQALA---REARKVEELQQQQQLAFQEHRLELERVHSDKNGEI 142
++ +LK E K + ALA + AR +L ++Q E + EL+RV S N E+
Sbjct: 1311 TQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 143 DHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALS 202
R +YE A+QR E L E + K+ +R + + ++ S
Sbjct: 1371 AQWRTKYET---------------DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 203 RELKVKLLHKELEAL------KEAGAKAAESLQR-AEATNAELERKLQSRAGELQDLEAM 255
E L E+E L A A A + QR + AE ++K + EL+ +
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 256 SRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQ---- 311
+R+ +L KL + + ETFKR+++ L + L G +V +L+
Sbjct: 1476 ARSLSTEL-FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL-GEGGKNVHELEKVRK 1533
Query: 312 ELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLS 371
+L+ LELQ+ E EA L E + E +Q++ + + D ++ Q
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLE----FNQIKAEIERKLAEKDEEMEQAK 1589
Query: 372 KEMVSRDLQIQTLQEEEVKLKAQVARSQQ----DIERYKQQLS----LAVERERSLERDQ 423
+ +QT + E + + +V R ++ D+ + QLS +A E ++ ++ Q
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1649
Query: 424 VQLGLDWQRRCDDIER--DQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVT 481
L D Q + DD R D ++++ A+++ + + A+L+E +++ E K
Sbjct: 1650 -SLLKDTQIQLDDAVRANDDLKENIAIVE---RRNNLLQAELEELRAVVEQTERSRKLA- 1704
Query: 482 LERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKE 541
E+E+ + S +Q L QNTSL N +M +
Sbjct: 1705 ---------------------------EQELIE--TSERVQLLHSQNTSLINQKKKMESD 1735
Query: 542 MEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLE 601
+ L ++ +Q E +A + +A DAA L+ E T H + ++K++E
Sbjct: 1736 LTQLQSEVEEAVQ---ECRNAEEKAKKAITDAAM--MAEELKKEQDTSAH-LERMKKNME 1789
Query: 602 DVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQA-GPVSSGLAL 660
+ L+ AE + A+ + G ++A Q + G S +
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 661 RKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAEL 716
++L + + + RL+ V + L+ A +R+ +Q + + + RK EL
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Score = 73.2 bits (178), Expect = 1e-12
Identities = 82/361 (22%), Positives = 159/361 (44%), Gaps = 33/361 (9%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRA---RVK 261
LK KE+ +KE + E+L+++EA ELE K+ S E DL+ +A +
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 262 DLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQ 321
D E++ + + + E K +E L+ E +A L A K ++ EL+ + +L+
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDIDDLE 960
Query: 322 AHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQI 381
+E + + A + E+ A +D++ + K A Q ++ + ++
Sbjct: 961 LTLAKVEKE-KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV 1019
Query: 382 QTLQEEEVKLKAQV----------ARSQQDIERYKQQ----LSLAVERERSLERDQVQLG 427
+L + +VKL+ QV + + D+ER K++ L L E LE D++QL
Sbjct: 1020 NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLE 1079
Query: 428 LDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQA 487
+++ DI + + + + L + K KL+E + ++E E L+A ER
Sbjct: 1080 EKLKKKEFDINQQNSKIEDEQVLALQLQK-----KLKENQARIEELEEELEA---ERTAR 1131
Query: 488 VQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSH 547
+ ++ R L + E + + ++ +Q E N +MR+++E +
Sbjct: 1132 AKVEKL----RSDLSRELEEISERLEEAGGATSVQ--IEMNKKREAEFQKMRRDLEEATL 1185
Query: 548 Q 548
Q
Sbjct: 1186 Q 1186
Score = 39.7 bits (91), Expect = 0.013
Identities = 60/261 (22%), Positives = 119/261 (45%), Gaps = 38/261 (14%)
Query: 11 NELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLE 70
N LL + EE RA+ + ++ A Q+ E Q L Q + N + E DL
Sbjct: 1680 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ--LLHSQNTSLINQKKKMESDLT 1737
Query: 71 L--ERYDAAFAQAREWEEARRAEVSELKIEAAKLRQA------LAREARKVEE------- 115
+ A + R EE + +++ + A +L++ L R + +E+
Sbjct: 1738 QLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1797
Query: 116 -LQQQQQLAFQEHRLELERVHS---DKNGEID-HHREQYENLKWTL--ERKLEEL----- 163
L + +Q+A + + +L+++ + + GE++ + E++K ER+++EL
Sbjct: 1798 RLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTE 1857
Query: 164 -DGELALQRQELL--LEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEA 220
D + L+ Q+L+ L+ + K KR+ E +A+ +NT LS+ KV+ EL+ +E
Sbjct: 1858 EDKKNLLRLQDLVDKLQLKVKAYKRQAE---EAEEQANTNLSKFRKVQ---HELDEAEER 1911
Query: 221 GAKAAESLQRAEATNAELERK 241
A + + A + ++ K
Sbjct: 1912 ADIAESQVNKLRAKSRDIGAK 1932
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 97.8 bits (242), Expect = 4e-20
Identities = 148/672 (22%), Positives = 282/672 (41%), Gaps = 109/672 (16%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVY--NLQVL 64
E + + L+ +E+E A+QA +A+ ++ ++++ QGK+R LQE N Q+
Sbjct: 308 EAKVKKQLVAREQEITAVQAR----MQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLA 363
Query: 65 EERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQ--- 121
+ DA + E + AE+++L+ E +K+ + L ++ V + +QQ++
Sbjct: 364 RLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALE 423
Query: 122 ---LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL------------DGE 166
AF++ L+L+ HRE E L+ L+ EL D E
Sbjct: 424 AKAAAFEKQVLQLQA----------SHRESEEALQKRLDEVSRELCHTQSSHASLRADAE 473
Query: 167 LALQRQELLLEFESKMRKREHEFRLQADNMS------NTALSRELKVKLLHKELEALKEA 220
A ++Q+ + E SK++ E E R + + +S A + ++ + +EAL EA
Sbjct: 474 KAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA 533
Query: 221 G-AKAAESLQRAEATNAELERKLQSRAGELQDL--------EAMSRARVK--DLEDKLHS 269
G A+ A+ +Q ++A + + +L+ ++ L EA+ + +VK DL +K
Sbjct: 534 GQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWK 593
Query: 270 VQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEA 329
E+ K K L + E + L ++ +E L L + L A
Sbjct: 594 AMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVL--------A 645
Query: 330 QLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEV 389
Q EW Q L+E T+ A A+ S ++ S+ ++ +E +
Sbjct: 646 QQNYTEWLQ------------DLKEKGPTLLKHPPAP-AEPSSDLASK---LREAEETQS 689
Query: 390 KLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
L+A + ++Y+ L+ R L++ + W+ + E +++QKS +
Sbjct: 690 TLQA-------ECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAE-EELQKSRVTV 741
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
+ L ++ +L+ ++Q ++E L+A LE+ A + + A + E
Sbjct: 742 KHLEEIVEKLKGELESSDQ-VREHTSHLEA-ELEKHMAAASAECQNYAKEVAGLRQLLLE 799
Query: 510 EEISKDFPSSEIQRLREQNTSLRNAIAQMRKEME--------ALSHQIPP----PIQ--T 555
+ D SE Q+ ++ +R +++M+ +E A S + PP P+Q T
Sbjct: 800 SQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
Query: 556 AAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDV--LDPLKMSSPH 613
E T+A D + T ++ A + R L++ LE + PL+ S
Sbjct: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACR--------LQEELEKLRTAGPLESSETE 911
Query: 614 AESQPSVRTSTE 625
SQ R E
Sbjct: 912 EASQLKERLEKE 923
Score = 85.1 bits (209), Expect = 3e-16
Identities = 139/688 (20%), Positives = 264/688 (38%), Gaps = 119/688 (17%)
Query: 64 LEERD--LELERYDAAFAQA--REWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQ 119
LEE++ L E+ DAA A++ RE + AE ++ AK+++ L +++ +Q +
Sbjct: 269 LEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQAR 328
Query: 120 QQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFE 179
Q +++EH E++++ G+I +EQ EN T +L++ + L + + E
Sbjct: 329 MQASYREHVKEVQQLQ----GKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 180 SKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
SK + R + +S + + V+ ++ +AL+ A + + + +A++ E E
Sbjct: 385 SKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESE 444
Query: 240 RKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVL 299
LQ R E+ +++ L Q ++++ H +L E +
Sbjct: 445 EALQKRLDEVSRELCHTQSSHASLRADAEKAQ----EQQQQMAELHSKLQSSEAEVRSKC 500
Query: 300 VAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
+ G H QLQE + +L ++EA L + R A + A DQ + +
Sbjct: 501 EELSGLH-GQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKEL 559
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSL 419
+S Q++ L KE A+E ++
Sbjct: 560 ES----QVSGLEKE--------------------------------------AIELREAV 577
Query: 420 ERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKA 479
E+ +V+ D +K+ ++ L+ A+ KL QA +E E L
Sbjct: 578 EQQKVK------------NNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625
Query: 480 VTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLR------EQNTSLRN 533
+ + +A+ AL P +L +Q+ E +D L+ E ++ L +
Sbjct: 626 IEAQTMEALLAL------LPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLAS 679
Query: 534 AIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDY---VLALEAEIRTLK 590
+ + + L + AE T+ D + + + V A E E++
Sbjct: 680 KLREAEETQSTLQAECDQYRSILAE-TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQ--- 735
Query: 591 HKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQ 650
K + KHLE++++ LK ES VR T + A S + V
Sbjct: 736 -KSRVTVKHLEEIVEKLK---GELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVA 791
Query: 651 AGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELR 710
LRQ +L + A + E ++ D++ L +R
Sbjct: 792 G-------------------------LRQLLLESQSQLDAAKSEAQKQSDELAL----VR 822
Query: 711 KQVAELGKHLRIAQHGGAEPSGRKQPPA 738
+Q++E+ H+ GA S + PPA
Sbjct: 823 QQLSEMKSHVEDGDIAGAPASSPEAPPA 850
Score = 59.7 bits (143), Expect = 1e-08
Identities = 118/532 (22%), Positives = 226/532 (42%), Gaps = 67/532 (12%)
Query: 17 KEEEWRALQAH-RTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE-RDLEL--- 71
+E++ + + H + Q EA + RS+ EE G LQE N Q+ E R +E
Sbjct: 476 QEQQQQMAELHSKLQSSEA---EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE 532
Query: 72 --ERYDAAFAQAREWEEARR--------AEVSELKIEAAKLRQALAREARKVEELQQQQQ 121
+ DA QA + E ++ ++VS L+ EA +LR+A+ ++ K +L+++
Sbjct: 533 AGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNW 592
Query: 122 LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEE----LDGELALQRQELLLE 177
A E E+ +K + +E+ E +E + E L EL++ Q+ E
Sbjct: 593 KAM-EALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
Query: 178 FESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAE 237
+ ++++ + + E L K EA + AE Q AE
Sbjct: 652 WLQDLKEKGPTL------LKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSIL-AE 704
Query: 238 LERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA 297
E L+ +++ E + RA+V E++L ++T K EE ++ EL+ + ++
Sbjct: 705 TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREH 764
Query: 298 VLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDAS 357
+H+E EL+ + A C+ ++ ++ + DAA + ++ +
Sbjct: 765 T------SHLE--AELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSD 816
Query: 358 TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERER 417
+ + Q++++ + D+ E ++QD + K QL E
Sbjct: 817 EL-ALVRQQLSEMKSHVEDGDIAGAPASSPE------APPAEQDPVQLKTQLEWT---EA 866
Query: 418 SLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQ--ETEQALQEQEV 475
LE +Q QR+ E ++ Q S +Q + K + A L+ ETE+A Q +E
Sbjct: 867 ILEDEQT------QRQKLTAEFEEAQTSACRLQE-ELEKLRTAGPLESSETEEASQLKER 919
Query: 476 VLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQ 527
+ K L D A R+ Q LL+ +E+++++ +++L+EQ
Sbjct: 920 LEKEKKLTSDLGRAATRL--------QELLKTTQEQLARE--KDTVKKLQEQ 961
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 97.8 bits (242), Expect = 4e-20
Identities = 148/672 (22%), Positives = 282/672 (41%), Gaps = 109/672 (16%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVY--NLQVL 64
E + + L+ +E+E A+QA +A+ ++ ++++ QGK+R LQE N Q+
Sbjct: 308 EAKVKKQLVAREQEITAVQAR----MQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLA 363
Query: 65 EERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQ--- 121
+ DA + E + AE+++L+ E +K+ + L ++ V + +QQ++
Sbjct: 364 RLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALE 423
Query: 122 ---LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL------------DGE 166
AF++ L+L+ HRE E L+ L+ EL D E
Sbjct: 424 AKAAAFEKQVLQLQA----------SHRESEEALQKRLDEVSRELCHTQSSHASLRADAE 473
Query: 167 LALQRQELLLEFESKMRKREHEFRLQADNMS------NTALSRELKVKLLHKELEALKEA 220
A ++Q+ + E SK++ E E R + + +S A + ++ + +EAL EA
Sbjct: 474 KAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA 533
Query: 221 G-AKAAESLQRAEATNAELERKLQSRAGELQDL--------EAMSRARVK--DLEDKLHS 269
G A+ A+ +Q ++A + + +L+ ++ L EA+ + +VK DL +K
Sbjct: 534 GQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWK 593
Query: 270 VQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEA 329
E+ K K L + E + L ++ +E L L + L A
Sbjct: 594 AMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVL--------A 645
Query: 330 QLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEV 389
Q EW Q L+E T+ A A+ S ++ S+ ++ +E +
Sbjct: 646 QQNYTEWLQ------------DLKEKGPTLLKHPPAP-AEPSSDLASK---LREAEETQS 689
Query: 390 KLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
L+A + ++Y+ L+ R L++ + W+ + E +++QKS +
Sbjct: 690 TLQA-------ECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAE-EELQKSRVTV 741
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
+ L ++ +L+ ++Q ++E L+A LE+ A + + A + E
Sbjct: 742 KHLEEIVEKLKGELESSDQ-VREHTSHLEA-ELEKHMAAASAECQNYAKEVAGLRQLLLE 799
Query: 510 EEISKDFPSSEIQRLREQNTSLRNAIAQMRKEME--------ALSHQIPP----PIQ--T 555
+ D SE Q+ ++ +R +++M+ +E A S + PP P+Q T
Sbjct: 800 SQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
Query: 556 AAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDV--LDPLKMSSPH 613
E T+A D + T ++ A + R L++ LE + PL+ S
Sbjct: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACR--------LQEELEKLRTAGPLESSETE 911
Query: 614 AESQPSVRTSTE 625
SQ R E
Sbjct: 912 EASQLKERLEKE 923
Score = 85.1 bits (209), Expect = 3e-16
Identities = 139/688 (20%), Positives = 264/688 (38%), Gaps = 119/688 (17%)
Query: 64 LEERD--LELERYDAAFAQA--REWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQ 119
LEE++ L E+ DAA A++ RE + AE ++ AK+++ L +++ +Q +
Sbjct: 269 LEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQAR 328
Query: 120 QQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFE 179
Q +++EH E++++ G+I +EQ EN T +L++ + L + + E
Sbjct: 329 MQASYREHVKEVQQLQ----GKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 180 SKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELE 239
SK + R + +S + + V+ ++ +AL+ A + + + +A++ E E
Sbjct: 385 SKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESE 444
Query: 240 RKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVL 299
LQ R E+ +++ L Q ++++ H +L E +
Sbjct: 445 EALQKRLDEVSRELCHTQSSHASLRADAEKAQ----EQQQQMAELHSKLQSSEAEVRSKC 500
Query: 300 VAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV 359
+ G H QLQE + +L ++EA L + R A + A DQ + +
Sbjct: 501 EELSGLH-GQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKEL 559
Query: 360 KSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSL 419
+S Q++ L KE A+E ++
Sbjct: 560 ES----QVSGLEKE--------------------------------------AIELREAV 577
Query: 420 ERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKA 479
E+ +V+ D +K+ ++ L+ A+ KL QA +E E L
Sbjct: 578 EQQKVK------------NNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625
Query: 480 VTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLR------EQNTSLRN 533
+ + +A+ AL P +L +Q+ E +D L+ E ++ L +
Sbjct: 626 IEAQTMEALLAL------LPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLAS 679
Query: 534 AIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDY---VLALEAEIRTLK 590
+ + + L + AE T+ D + + + V A E E++
Sbjct: 680 KLREAEETQSTLQAECDQYRSILAE-TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQ--- 735
Query: 591 HKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQ 650
K + KHLE++++ LK ES VR T + A S + V
Sbjct: 736 -KSRVTVKHLEEIVEKLK---GELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVA 791
Query: 651 AGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELR 710
LRQ +L + A + E ++ D++ L +R
Sbjct: 792 G-------------------------LRQLLLESQSQLDAAKSEAQKQSDELAL----VR 822
Query: 711 KQVAELGKHLRIAQHGGAEPSGRKQPPA 738
+Q++E+ H+ GA S + PPA
Sbjct: 823 QQLSEMKSHVEDGDIAGAPASSPEAPPA 850
Score = 59.7 bits (143), Expect = 1e-08
Identities = 118/532 (22%), Positives = 226/532 (42%), Gaps = 67/532 (12%)
Query: 17 KEEEWRALQAH-RTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE-RDLEL--- 71
+E++ + + H + Q EA + RS+ EE G LQE N Q+ E R +E
Sbjct: 476 QEQQQQMAELHSKLQSSEA---EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE 532
Query: 72 --ERYDAAFAQAREWEEARR--------AEVSELKIEAAKLRQALAREARKVEELQQQQQ 121
+ DA QA + E ++ ++VS L+ EA +LR+A+ ++ K +L+++
Sbjct: 533 AGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNW 592
Query: 122 LAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEE----LDGELALQRQELLLE 177
A E E+ +K + +E+ E +E + E L EL++ Q+ E
Sbjct: 593 KAM-EALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
Query: 178 FESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAE 237
+ ++++ + + E L K EA + AE Q AE
Sbjct: 652 WLQDLKEKGPTL------LKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSIL-AE 704
Query: 238 LERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA 297
E L+ +++ E + RA+V E++L ++T K EE ++ EL+ + ++
Sbjct: 705 TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREH 764
Query: 298 VLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDAS 357
+H+E EL+ + A C+ ++ ++ + DAA + ++ +
Sbjct: 765 T------SHLE--AELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSD 816
Query: 358 TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERER 417
+ + Q++++ + D+ E ++QD + K QL E
Sbjct: 817 EL-ALVRQQLSEMKSHVEDGDIAGAPASSPE------APPAEQDPVQLKTQLEWT---EA 866
Query: 418 SLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQ--ETEQALQEQEV 475
LE +Q QR+ E ++ Q S +Q + K + A L+ ETE+A Q +E
Sbjct: 867 ILEDEQT------QRQKLTAEFEEAQTSACRLQE-ELEKLRTAGPLESSETEEASQLKER 919
Query: 476 VLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQ 527
+ K L D A R+ Q LL+ +E+++++ +++L+EQ
Sbjct: 920 LEKEKKLTSDLGRAATRL--------QELLKTTQEQLARE--KDTVKKLQEQ 961
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 97.1 bits (240), Expect = 7e-20
Identities = 130/561 (23%), Positives = 246/561 (43%), Gaps = 59/561 (10%)
Query: 13 LLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELE 72
L LR + WR + LQ + ++ EE K+R Q E R E+E
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQ-------LAAENRLTEME 872
Query: 73 RYDAAF-AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLEL 131
+ A+ + +E +AE +EL EA +LR L + +++EE+ + +E
Sbjct: 873 TLQSQLMAEKLQLQEQLQAE-TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931
Query: 132 ERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLE---FESKMRKREHE 188
+ + ++K ++ +N++ LE +LEE + RQ+L LE E+K++K E E
Sbjct: 932 QHLQAEK-------KKMQQNIQ-ELEEQLEEEESA----RQKLQLEKVTTEAKLKKLEEE 979
Query: 189 FRLQADNMSNTALSREL---KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSR 245
+ D A ++L ++ L +E A+ + EA +LE +L+
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 246 AGELQDLEAMSR---ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDR-LAREKDAVLVA 301
+ Q+LE R DL D++ +Q + + +K EEL LAR ++ A
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA--A 1097
Query: 302 VKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKS 361
K +++++EL++++ ELQ E+ A +AE ++ D +E +A +L + +
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA- 1156
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLER 421
AQ SK ++ +TL+EE +AQ+ +Q + ++L+ +E+ +
Sbjct: 1157 ---AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK---- 1209
Query: 422 DQVQLGLDWQRRCDDIERDQI-QKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAV 480
+V+ L+ ++ + ER ++ + + L+QG K K ++ E LQE +V
Sbjct: 1210 -RVKANLEKAKQTLENERGELANEVKVLLQG----KGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 481 TLERDQAVQALRMHGLPRPGAQMLLRQHE---EEISKDFPSSE---------IQRLREQN 528
R + + + LL Q + +++KDF + E +Q Q
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 529 TSLRNAIAQMRKEMEALSHQI 549
SL + Q+ E + Q+
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQL 1345
Score = 76.6 bits (187), Expect = 1e-13
Identities = 115/510 (22%), Positives = 224/510 (43%), Gaps = 76/510 (14%)
Query: 42 QLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQ---------AREWEEARRAEV 92
+LE+ + +L+ +D + +L + LE+ F Q A+ EE RAE
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 93 SELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNG------EIDHHR 146
+ E L +LAR + E + + + ++ R E+E + S K+ E++ +
Sbjct: 1470 EAREKETKAL--SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 147 EQYENLKWTLERKLEELDGEL-ALQRQELLLEFESKMRKREHEFRLQADNMSNTALSREL 205
E ++ +LEEL+ EL A + +L LE + K + E LQ + + ++L
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 206 --KVKLLHKELEALKEAGAKAAESLQRAEATNAELE-----------------RKLQSRA 246
+V+ + ELE ++ + A + ++ E +LE RKLQ++
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 247 G----ELQDLEAMSR---ARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVL 299
EL D A A+ K+ E KL S++ + +E + +E+D +
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 300 VAV-----KGA-HVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLR 353
+ KGA +E+ + L+ R+ +L+ E LE + E D K+ + IDQ+
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLE---EELEEEQGNTELIN-DRLKKANLQIDQIN 1763
Query: 354 EDASTVKS-AWDAQIAQLSKEMVSRDLQIQTLQEEE-----------VKLKAQVARSQQD 401
D + +S A + A+ E +++L+++ LQE E L+A++A+ ++
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 402 IERYKQQLSLAVERERSLERD--QVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQV 459
++ ++ A ++ R E+ V L +D +RR + +DQ K+ ++ Q+
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLK-------QL 1875
Query: 460 AAKLQETEQALQEQEVVLKAVTLERDQAVQ 489
+L+E E+ Q + + E + A +
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Score = 75.9 bits (185), Expect = 2e-13
Identities = 140/657 (21%), Positives = 268/657 (40%), Gaps = 136/657 (20%)
Query: 33 EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEV 92
E+ LQDT+ L+E + L QV +E++ E Q E EEA+
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLK---QVEDEKNSFRE-------QLEEEEEAKH--- 1353
Query: 93 SELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQ---Y 149
L+ + A L +A +K+E+ + A + R ++ D G H E+ Y
Sbjct: 1354 -NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR----KLQKDLEGLSQRHEEKVAAY 1408
Query: 150 ENLKWTLERKLEELDG---ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRE-L 205
+ L+ T R +ELD +L QRQ E K +K + + + A R+
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSAC-NLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 206 KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQD-------------- 251
+ + KE +AL A +L+ A AELER + E++D
Sbjct: 1468 EAEAREKETKALS-----LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 252 LEAMSRA----------RVKDLEDKLHSVQLTRKK------------------EEETFKR 283
LE RA ++++LED+L + + + + +E +
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 284 KHEELDRLAREKDAVLV---AVKGAHVEQLQELQTRVLELQAHCET-------------- 326
K ++L R RE +A L + V ++L+ + +L+AH ++
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Query: 327 LEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQ- 385
L+AQ++ DT ++ + Q +E+ +KS +A++ QL +E+ + + + Q
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEAEMIQLQEELAAAERAKRQAQQ 1701
Query: 386 --------------------EEEVKLKAQVARSQQDIERYKQQLSLAVER--ERSLERDQ 423
EE+ +L+A++A+ ++++E + L +R + +L+ DQ
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 424 VQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQ-EVVLKAVTL 482
+ L ++ER QK+E Q L ++ KLQE E ++ + + + A+
Sbjct: 1762 INTDL-------NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEA 1814
Query: 483 ERDQAVQALRMHGLPRPGAQMLLRQHEEEISK-----DFPSSEIQRLREQNTSLRNAIAQ 537
+ Q + L R A +R+ E+++ D ++ ++Q + Q
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 538 MRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFK 594
+++++E + Q A S Q + E + A A+ E+ +LK+K +
Sbjct: 1875 LKRQLEEAEEE----AQRANASRRKLQRELEDATETAD-----AMNREVSSLKNKLR 1922
Score = 69.7 bits (169), Expect = 1e-11
Identities = 103/452 (22%), Positives = 185/452 (40%), Gaps = 57/452 (12%)
Query: 9 ALNELLLRKEEEWRALQAHRTQLQEAA------------LQDTRSQLEEAQGKLRCLQED 56
AL E + +K E R + RT++++ L+ ++ LE+ +++ E+
Sbjct: 1484 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE 1543
Query: 57 FVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL 116
LQ E+ L LE A E + R E SE K + +RQ EA +E
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK-KKQLVRQVREMEAELEDER 1602
Query: 117 QQQQQLAFQEHRLELE----RVHSDK-NGEIDHHREQYENLKWTLERKLEELDGELALQR 171
+Q+ +LE++ H D N D +Q L+ ++ + ELD A R
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA-SR 1661
Query: 172 QELLL---EFESKMRKREHEF-RLQADNMSNTALSRELKVKL--LHKELEALKEAGAKAA 225
+E+L E E K++ E E +LQ + + R+ + + L E+ GA A
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 226 ESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKH 285
E +R EA A+LE +L+ G + + R+K ++ + E ++
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTE----LINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 286 EELDRLAREKDAVLVAVKGAHVEQLQELQTRVL-ELQAHCETLEAQLRRAEWRQADTAKE 344
+L R+ + V +LQE++ V + +A LEA++ + E + + KE
Sbjct: 1778 NARQQLERQNKELKV--------KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 345 KDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIER 404
+ AA Q+R +K LQ+ + + K Q ++ +++
Sbjct: 1830 RQAACKQVRRTEKKLKDVL---------------LQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 405 YKQQLSLAVERERSLERDQVQLGLDWQRRCDD 436
K+QL A E + + +L QR +D
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKL----QRELED 1902
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 95.1 bits (235), Expect = 3e-19
Identities = 121/575 (21%), Positives = 247/575 (42%), Gaps = 42/575 (7%)
Query: 1 MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN 60
+LP L E + R+EEE R Q + + QE + +L E +GK+R +E
Sbjct: 261 LLPQVQTNTLQEEMWRQEEELRE-QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQ 319
Query: 61 LQVLEERDLELERYDAAF---AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL- 116
+ L E++ EL + + RE EE + + ++ + K+R+ + R+ E L
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 117 -------QQQQQLAFQEHRL-ELERVHSDKNGEIDHHREQYENL-KWTLERKLEE----- 162
+Q+Q++ QE R+ E + +K + + +E + K E+K++E
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 163 LDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALS------RELKVKLLHKELEA 216
D E +Q +E + E E KMR+ E R Q + M + +E + + L ++ E
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
Query: 217 LKEAGAKAAESLQRAEATNAELERKLQSRAGEL--QDLEAMSRARVKDLEDKLHSVQLTR 274
L E E +Q E E E K++ + E+ Q+ + + ++++ ED++ +
Sbjct: 500 LWE-----QEKMQEQEEKIWEQEEKIRDQE-EMWGQEKKMWRQEKMREQEDQMWEQEEKM 553
Query: 275 KKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRA 334
+ +E+ + E +++ +E++ K E+ + R+ E + E +R
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEK-----KTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Query: 335 EWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQ 394
E + + ++ +++ E ++ + Q K + + + E K K
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 395 VARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
Q+ E+ ++Q E+E+ ++ Q Q W + E ++ + + + M
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 455 AKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPR-PGAQMLLRQHEEEIS 513
+ Q K+QE E+ +QEQE + E Q +M R P + L +HE+
Sbjct: 729 MREQ-EEKMQEQEEKMQEQEE--EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
Query: 514 KDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ 548
++ + +++R+Q +R +MR + E + Q
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
Score = 85.5 bits (210), Expect = 2e-16
Identities = 106/571 (18%), Positives = 250/571 (43%), Gaps = 56/571 (9%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY 74
L KE + +L+ +R + L+ ++L+E + + N++ L+ R LE ++
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK-RKLERAKF 260
Query: 75 DAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQ-QLAFQEHRL-ELE 132
Q +E + EL+ + K+R+ + R+ E L++Q+ ++ QE ++ E
Sbjct: 261 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQE 320
Query: 133 RVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQ 192
+ ++ E+ REQ + L+ E + +E E +++E + E E KMR++E + Q
Sbjct: 321 KRLREQEKEL---REQEKELREQKELREQE---EQMQEQEEKMWEQEEKMREQEEKMWRQ 374
Query: 193 ADNM-SNTALSRELKVKLLHKELEALKEAGAKAAESLQR--------AEATNAELERKLQ 243
+ + RE + K+ +E E + E + E +R + E+K+Q
Sbjct: 375 EERLWEQEKQMREQEQKMRDQE-ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ 433
Query: 244 SRAGELQDLE--AMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEEL----------DRL 291
+ + +D E R+++ E K+ + T +++EE +++ E + RL
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 292 AREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQ--LRRAEWRQADTAKEKDAAI 349
+K+ K E++QE + ++ E + E + WRQ +++D
Sbjct: 494 PEQKE------KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 547
Query: 350 DQLREDASTVKSAWDAQ--IAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQ 407
+Q + + WD + + + ++E + + EE +++ + + +++ E ++
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607
Query: 408 QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQ--------- 458
Q E+E ++ + ++ ++ + E+ Q+ + Q M + Q
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 459 -VAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFP 517
K+QE E+ +++E + + +E+ Q + + + +R+ E+++ +
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE--- 724
Query: 518 SSEIQRLREQNTSLRNAIAQMRKEMEALSHQ 548
E + +REQ ++ +M+++ E + Q
Sbjct: 725 --EEEMMREQEEKMQEQEEKMQEQEEEMWEQ 753
Score = 82.8 bits (203), Expect = 1e-15
Identities = 107/567 (18%), Positives = 252/567 (44%), Gaps = 64/567 (11%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLEL 71
E + +EE+ R Q + QE L + Q+ E + K+R +E ++ E+ +
Sbjct: 355 EKMWEQEEKMRE-QEEKMWRQEERLWEQEKQMREQEQKMRDQEE------RMWEQDERLR 407
Query: 72 ERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRL-- 129
E+ + Q + WE+ + E K+++ + + E++Q+++++ +E ++
Sbjct: 408 EKEERMREQEKMWEQVEKMR------EEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE 461
Query: 130 --ELERVHSDKNGEIDHHREQYENLKWTLERKLEE----LDGELALQRQELLLEFESKMR 183
E R +K + + + + E +W +R E+ + E +++E + E E K+R
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Query: 184 KREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQ 243
+E E Q M RE + ++ +E E +++ K + +R E E E+K
Sbjct: 522 DQE-EMWGQEKKMWRQEKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
Query: 244 SRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK 303
+ ++++ E M R R K + ++ ++ +K +E ++ E+ +++ +++ + +
Sbjct: 580 DQEEKMREEERM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Query: 304 --GAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAI-DQLREDAST-- 358
E++ E + ++ E Q E E + ++ + +E++ I +Q + + T
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 359 -VKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERER 417
K WD + + + M R+ + ++EEE ++ Q + Q+ E+ ++Q E+E
Sbjct: 699 QEKKTWDQEKMREEESMRERE---KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 418 SLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVL 477
+ + ++ W+++ +++++ + E K Q K+ E E+ +++QE +
Sbjct: 756 KMWEQEEKM---WEQQRLPEQKEKLWEHE---------KMQEQEKIWEQEEKMRDQEEKM 803
Query: 478 KAVTLERDQAVQALRMHGLPRP----------------GAQMLLRQHEEEISKDFPSSEI 521
+ E Q +M G G + + EE++ + E
Sbjct: 804 RG--QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE- 860
Query: 522 QRLREQNTSLRNAIAQMRKEMEALSHQ 548
+++REQ +R +MR++ E + Q
Sbjct: 861 EKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 53.9 bits (128), Expect = 7e-07
Identities = 52/301 (17%), Positives = 127/301 (42%), Gaps = 35/301 (11%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLEL 71
E ++R++EE Q + Q QE + + +++E + K+ +E + + E+
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 72 ERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKV---EELQQQQQLAFQEHR 128
E+ + + + E+ + E E E K+ + + +K E++++++ + +E +
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 129 L----ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGEL----------------- 167
+ E+ R +K E + ++ E W E K+ E + ++
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 168 ALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAES 227
+Q QE + E E KMR +E + R Q + M +++ +E E
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ-----------EEKMRGQEEKMWGQEEK 830
Query: 228 LQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEE 287
+ E E K+ + ++++ ++++ E+K+ + +++EE + + E+
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Query: 288 L 288
+
Sbjct: 891 I 891
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 94.4 bits (233), Expect = 4e-19
Identities = 97/475 (20%), Positives = 219/475 (46%), Gaps = 21/475 (4%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY 74
L KE + +L+ +R + + L++ ++L+E + + + N++ L+ + LER
Sbjct: 259 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERA 315
Query: 75 DAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERV 134
Q + EA EL+ +AKL QA E L QQQ+ +++
Sbjct: 316 KLLLPQQQLQAEADHLG-KELQSVSAKL-QAQVEENELWNRLNQQQEEKMWRQEEKIQEW 373
Query: 135 HSDKNGEIDHHREQYENLKWTLE--RKLEEL--DGELALQRQE-LLLEFESKMRKREHEF 189
+ + REQ E ++ E R+ EE+ + E ++RQE ++ E E KMR++E
Sbjct: 374 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 433
Query: 190 RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGEL 249
+ + + + K+ +E + +E + E Q EA E K++ + ++
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493
Query: 250 QDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHV-- 307
++ E ++ E+K+H + R++E+ + + + RE++ + + H
Sbjct: 494 REQEE----KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549
Query: 308 EQLQELQTRVLELQAHCETLEAQLRRAE---WRQADTAKEKDAAIDQLREDASTVKSAWD 364
E++++ + ++ + E ++R E WRQ + +E++ I + E +
Sbjct: 550 EKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQ 609
Query: 365 AQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQV 424
Q ++ ++ Q + +QE+E K++ Q + ++ ++ ++Q E+E ++ +
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 669
Query: 425 QLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKA 479
++ ++ C+ E+ Q Q+ + Q M + +V +L++ E+ +QE + L+A
Sbjct: 670 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV--RLRQQEEKMQEHQEHLEA 722
Score = 60.1 bits (144), Expect = 9e-09
Identities = 78/379 (20%), Positives = 163/379 (43%), Gaps = 42/379 (11%)
Query: 202 SRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVK 261
S E + K H+ EAL+ +++ EL+ L ++ LE +R +
Sbjct: 167 SPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 226
Query: 262 ----------DLEDKLHSVQLTRKKEEETFKRKHEELDRLARE------KDAVLVAVKGA 305
+LE L +V +KK + + +E D L+ E D L
Sbjct: 227 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 286
Query: 306 HVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDA 365
E+LQ +++ E+Q + + L+ +L RA+ ++ A D L ++ +V + A
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ--QQLQAEADHLGKELQSVSAKLQA 344
Query: 366 QI----------AQLSKEMVSRDLQIQ----TLQEEEVKLKAQVARSQQDIERYKQQLSL 411
Q+ Q ++M ++ +IQ +QE+E K++ Q + ++ E+ ++Q +
Sbjct: 345 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 404
Query: 412 AVERERSLERDQVQLGLDWQRRCDDIER--DQIQKSEALIQGLSMAKSQVAAKLQETEQA 469
E+E + R + + W++ + + R + + + E I+ L K K++E E+
Sbjct: 405 MWEKEEKMRRQEEMM---WEKE-EKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEK 459
Query: 470 LQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNT 529
QE+E + + ++Q + R R + + Q E+ ++ E +++RE+
Sbjct: 460 RQEEEKI-REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 530 SLRNAIAQMRKEMEALSHQ 548
R +M ++ E + Q
Sbjct: 519 --RQEQEEMWRQEEKIREQ 535
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 93.6 bits (231), Expect = 8e-19
Identities = 155/696 (22%), Positives = 303/696 (43%), Gaps = 116/696 (16%)
Query: 5 GSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL 64
G LN+L +E+ LQ TQL E + S ++AQ L ++ +L+
Sbjct: 558 GETAVLNQL----QEKNHTLQEQVTQLTEKLKNQSESH-KQAQENLHDQVQEQKAHLRAA 612
Query: 65 EERDLELER-YDAAFAQAREWEEARRAEVSELKIEA-AKLRQALAREARKVEELQQQQ-- 120
++R L LE + +Q E +E +VS+L I+ AK L+ EA K + Q
Sbjct: 613 QDRVLSLETSVNELNSQLNESKE----KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668
Query: 121 ----QLAFQEHRLELERVHS----------DKN---GEIDHHREQYENLKWTLERKLEEL 163
Q A Q+ + EL ++ + DK +++ H ++Y+ +LE+K EEL
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 164 DGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEA--- 220
+G++ + L E K K + LQ NT L EL+ L K+LE KE
Sbjct: 729 EGQIKKLEADSL---EVKASKEQALQDLQQQRQLNTDL--ELRATELSKQLEMEKEIVSS 783
Query: 221 -------GAKAAESL----------------------QRAEATNAELERKLQSRAGELQD 251
++A ES+ Q + + EL ++Q+ ELQ
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 252 LEAMSRARVKDL---EDKLHSVQLTRKKEEETFKRKHE-------ELDRLARE-KDAVLV 300
++ A + +L +DKL V + K + F+++++ +L++ +E K + V
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 301 AVKGAHVEQLQELQTRVLELQA-HCETLEAQLRRAEWRQA-DTAKEKDAAIDQLREDAST 358
++ EQ + ++ E +A H LE + + QA +T K+ + QL+ + +
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 359 VKSAWDAQIAQLSKEMVSRDLQIQTLQEEEV--KLKAQVARSQQDIERYKQQLSLAVERE 416
+K + + + Q+ E + +L+I LQ+ E+ KL+ Q+ ++ Q++ K+++S+
Sbjct: 964 LKQSSEQKKKQI--EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 417 RSLERDQVQLGLDWQRRCDDI-----------------------ERDQIQKSEALIQGLS 453
+ QL D+ R ++ R+QI LIQ L
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081
Query: 454 MAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEIS 513
AK+ + + EQ LQE+ L+ + E+ + L + + + E+EI+
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
Query: 514 K---DFPSSEIQRLREQNTSLRNA---IAQMRKEMEALSHQIPPPIQTAAESTDANQPDP 567
K + S +++ ++E T+L++A + Q + E++ + + ++ + +
Sbjct: 1142 KLNEELKSHKLESIKE-ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 568 EAGGDAATPDYVLALEAEIRT-LKHKFKTLEKHLED 602
+ + +++ EA++ + +K K ++KH E+
Sbjct: 1201 KKEEEELKKEFI-EKEAKLHSEIKEKEVGMKKHEEN 1235
Score = 90.5 bits (223), Expect = 6e-18
Identities = 117/579 (20%), Positives = 262/579 (45%), Gaps = 68/579 (11%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
KE+ LQ+ QL L+ T QL EA G+L+ E + + L +++ ++
Sbjct: 405 KEQHGLQLQSEINQLHSKLLE-TERQLGEAHGRLK---EQRQLSSEKLMDKEQQVADLQL 460
Query: 77 AFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVH- 135
++ E + + +EL+ + K +Q + ++ + LQQ +E + +LE+V
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQ----QHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 136 --SDKNGEIDHH----REQYENLKWTLERKLEEL-------DGELALQRQ---------E 173
DK+ +I + ++ EN+ LE++ E+L +GE A+ Q E
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENIS-LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575
Query: 174 LLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEA 233
+ + K++ + + +N+ + ++ ++ + +L+ + + L ++
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635
Query: 234 TNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAR 293
++L+ +++++ L EA A+ DL++ L + Q + K +EL+++
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ-------NALQDKQQELNKITT 688
Query: 294 EKDAVLVAV--KGAHVEQLQ----ELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDA 347
+ D V + K H QL+ E + + L L+ E LE Q+++ E + K+
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 348 AIDQLREDASTVKSAWDAQIAQLSKEM-------VSRDLQIQTLQEEEVKLKAQVARSQQ 400
A+ L++ + + + + +LSK++ S L +Q E +K ++ + ++
Sbjct: 749 ALQDLQQQRQ-LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Query: 401 DIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAK---S 457
+ + KQ + +E ++ +++ + Q ++++ +++K EAL+ LS K S
Sbjct: 808 EKQILKQDFE-TLSQETKIQHEELNNRI--QTTVTELQKVKMEK-EALMTELSTVKDKLS 863
Query: 458 QVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE--EEISKD 515
+V+ L+ ++ +++ KA L+ ++ + L+ H L L Q E + + K+
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEKE 922
Query: 516 FPSS-----EIQRLREQNTSLRNAIAQMRKEMEALSHQI 549
+S E+ ++EQ +N + Q KE + L I
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Score = 89.4 bits (220), Expect = 1e-17
Identities = 167/856 (19%), Positives = 363/856 (42%), Gaps = 125/856 (14%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQV-LEERD 68
L E LL+KE+++ T+L+E +++ S+ N+Q L ++D
Sbjct: 307 LTENLLKKEQDY-------TKLEEKHNEESVSKK----------------NIQATLHQKD 343
Query: 69 LELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQ------QQQQL 122
L+ ++ + + + E+SE KL++ L+ K + L+ QQQ+
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 123 AFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKM 182
++H L+L+ + + ++ Q L+ + +L E + +++ + + + K+
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ-RQLSSEKLMDKEQQVADLQLKL 462
Query: 183 RKREHEFRLQADNMSNTALSREL-KVKLLHKELEALKEAGAKAAESLQRAEATNAELERK 241
+ E + + + N +T L +L K K H+E +AL+++ L+ A+ ++ R+
Sbjct: 463 SRLEEQLKEKVTN--STELQHQLDKTKQQHQEQQALQQS---TTAKLREAQNDLEQVLRQ 517
Query: 242 LQSRAGELQDLEAM---------------------------SRARVKDLEDKLHSV---- 270
+ + ++Q+LEA+ A + L++K H++
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 271 -QLTR--KKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETL 327
QLT K + E+ K+ E L +E+ A L+ Q RVL L+ L
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKA-----------HLRAAQDRVLSLETSVNEL 626
Query: 328 EAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEE 387
+QL ++ + + D I E + ++A AQ A L + + +Q Q+E
Sbjct: 627 NSQLNESK----EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 388 EVKLKA---QVARSQQDIERYKQQLS--LAVERERSLERDQVQLGLDWQRRCDDIERDQI 442
K+ QV QD + + QL L +E+ L +Q L+ Q + +E D +
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK--KLEADSL 740
Query: 443 Q----KSEAL--IQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLE---RDQAVQALRM 493
+ K +AL +Q + + + E + L+ ++ ++ + L+ + +A+++++
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 494 HGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRK---EMEALSHQIP 550
+ + +L+Q E +S++ ++IQ E N ++ + +++K E EAL ++
Sbjct: 801 KLTKQEEEKQILKQDFETLSQE---TKIQH-EELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 551 PPIQTAAESTDA--NQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
++ +D+ N + +L LE + LKH+ L+ +E+ L K
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ---LQVQMENTLKEQK 913
Query: 609 --MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDR 666
S E + S + E Q QA +++ + G ++ +L
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNIN------ELKQS 967
Query: 667 VQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHLRIAQHG 726
+ + L+ ++ L+ L+ +L +++ Q E+ +++++ L + +Q
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 727 GAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKT-QH 785
+ S+ +A R+D KS E++ R+ Q+G++ +Q KT +
Sbjct: 1028 FKQLQSDFYGRESELLAT-RQDLKSVEEKLSLAQEDLISNRN-QIGNQNKLIQELKTAKA 1085
Query: 786 SIHTVTCKSPRQKEDR 801
++ + K +Q ++R
Sbjct: 1086 TLEQDSAKKEQQLQER 1101
Score = 69.7 bits (169), Expect = 1e-11
Identities = 149/746 (19%), Positives = 298/746 (39%), Gaps = 113/746 (15%)
Query: 88 RRAEVSELKIEAAKLRQALAREARKVEELQQQQQL--AFQEHRLELERVHSDKNGEIDHH 145
+R +V+ L+ E L+ +L E EEL+++ + Q+ + + + +D + E+
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-- 138
Query: 146 REQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSREL 205
+LE++LEE E +Q L FE K + E AD S R L
Sbjct: 139 ---------SLEQQLEEAQTENFNIKQMKDL-FEQKAAQLATEI---ADIKSKYDEERSL 185
Query: 206 KVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLED 265
+ EA ++ + E L + +L+ +L R G ++D+ + + V+ ++
Sbjct: 186 R--------EAAEQKVTRLTEELNKEATVIQDLKTELLQRPG-IEDVAVLKKELVQ-VQT 235
Query: 266 KLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVK----------GAHVEQLQELQT 315
+ ++ L R++E E K + ++L +A + ++ +V++LQ+L++
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 316 RVLELQAHCETLEAQLRRAEWRQADTAKEKD-AAIDQLREDASTVKSAWDAQIAQLSKEM 374
V EL +TL L + KE+D +++ + S K A + Q
Sbjct: 296 SVNELTQKNQTLTENLLK---------KEQDYTKLEEKHNEESVSKKNIQATLHQ----- 341
Query: 375 VSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRC 434
+DL Q LQ ++++ S+ + R +LS E + L+ + ++ +Q
Sbjct: 342 --KDLDCQQLQ-------SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 435 DDIERDQIQKSEALIQGLSMAK--SQVAAKLQETEQ-------ALQEQEVVLKAVTLERD 485
+ ++ Q Q+ E GL + +Q+ +KL ETE+ L+EQ + ++++
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
Query: 486 QAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEAL 545
Q V L++ L R E+ K S+E+Q ++ Q +E +AL
Sbjct: 453 QQVADLQL---------KLSRLEEQLKEKVTNSTELQHQLDKT-------KQQHQEQQAL 496
Query: 546 SHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLD 605
++ A D Q + G + LEA ++ K LEK ED+
Sbjct: 497 QQSTTAKLREA--QNDLEQVLRQIGD---KDQKIQNLEALLQKSKENISLLEKEREDLYA 551
Query: 606 PL-----------KMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPV 654
+ ++ + Q V TE +++ + QA ++
Sbjct: 552 KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK--------QAQENLHDQVQ 603
Query: 655 SSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVA 714
LR DRV L V L ++ + + L ++ + + + Q A
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
Query: 715 ELGKHLRIAQHG--GAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVG 772
+L HL AQ+ + K D V +D + + S HL +++ + +
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES-HLKEYKEKYLSLE 722
Query: 773 SRLDALQGPKTQHSIHTVTCKSPRQK 798
+ + L+G + ++ K+ +++
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQ 748
Score = 63.2 bits (152), Expect = 1e-09
Identities = 95/411 (23%), Positives = 185/411 (45%), Gaps = 51/411 (12%)
Query: 14 LLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELER 73
L + E+E + LQ + +L++++ Q + Q+E QG+L+ + VL++ +LE +
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQK-KKQIEALQGELK---------IAVLQKTELE-NK 995
Query: 74 YDAAFAQAREWEEARRAEVSELKIEAAKLRQALAR-----EARKVEELQQQQQLAFQEHR 128
QA + A + ++S L+ K ++ + R+ E L +Q L E +
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 129 LEL--ERVHSDKN--GEIDHHREQYENLKWTLE--------------RKLEELDGELALQ 170
L L E + S++N G + ++ + K TLE + L+++ E +L+
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 171 RQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLH--KELEALKEAGA----KA 224
+EL+ E +SK+ + E E + + + T L+ ELK L KE+ LK+A +
Sbjct: 1116 EKELVNE-KSKLAEIE-EIKCRQEK-EITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 225 AESLQRAEATNAELE---RKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETF 281
E +A++ A +E R Q +++ E + + E KLHS KE+E
Sbjct: 1173 LELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS----EIKEKEVG 1228
Query: 282 KRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADT 341
+KHEE + + L G ++ Q Q RV EL+ + L ++ E +
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288
Query: 342 AKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLK 392
E+ A +++ + ++ ++ +L +++ + +Q L E L+
Sbjct: 1289 QDERRALLERCLKGEGEIEKL-QTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 47.4 bits (111), Expect = 6e-05
Identities = 65/270 (24%), Positives = 126/270 (46%), Gaps = 24/270 (8%)
Query: 18 EEEWRALQAHRTQ--LQEAALQDTRSQLEEAQGKLRCLQEDFVYNL-QVLEERDLELERY 74
+E +ALQ + + L+E L + +S+L E + +++C QE + L + L+ LE +
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIE-EIKCRQEKEITKLNEELKSHKLESIKE 1157
Query: 75 DAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLEL--- 131
A++ ++ E L+ +A L+ A+ +E R + L+ Q + +E + E
Sbjct: 1158 ITNLKDAKQLLIQQKLE---LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
Query: 132 -ERVHSD-KNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEF 189
++HS+ K E+ + + K T++ + L+ L ++E ++S R R E
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQ--ITALNENLGTVKKE----WQSSQR-RVSEL 1267
Query: 190 RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGEL 249
Q D++ E V+ E AL E K +++ + EL+RKL + +
Sbjct: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Query: 250 QDLEAMSRARVKDLEDKLHSVQLTRKKEEE 279
Q+L +++ L+ K H+ L RK E+
Sbjct: 1328 QELGRENQS----LQIK-HTQALNRKWAED 1352
Score = 30.8 bits (68), Expect = 6.0
Identities = 33/131 (25%), Positives = 60/131 (45%), Gaps = 22/131 (16%)
Query: 9 ALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERD 68
ALNE L ++EW++ Q ++L++ Q ++ +G++ L E V N Q +ER
Sbjct: 1245 ALNENLGTVKKEWQSSQRRVSELEK--------QTDDLRGEIAVL-EATVQNNQ--DERR 1293
Query: 69 LELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHR 128
LER E+ +L+ + +L++ L V+EL ++ Q +H
Sbjct: 1294 ALLERCLKG-----------EGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1342
Query: 129 LELERVHSDKN 139
L R ++ N
Sbjct: 1343 QALNRKWAEDN 1353
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 93.6 bits (231), Expect = 8e-19
Identities = 182/833 (21%), Positives = 337/833 (40%), Gaps = 158/833 (18%)
Query: 18 EEEWRALQAHRTQLQEAALQ------DTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLEL 71
EE+++ L A +Q + L D R Q+ Q +L+ +Q + L+ E+
Sbjct: 509 EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEI 568
Query: 72 ERYDAAFAQAREWEEARRAEVSELK---------IEAAKLRQALAREARKVEELQQQQQL 122
++ R+W + + A E + I+ ++ QA E K+E + QQL
Sbjct: 569 ----SSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
Query: 123 AFQEHR---------LELERVHSD---KNGEIDHHREQYENLKWTLERKLEELDGELALQ 170
+HR +L+ + +D + +E ++ L+R+LEE +GE
Sbjct: 625 TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGE---- 680
Query: 171 RQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQR 230
R+ L +M Q + + T L R+ +++ L +E L + E+LQ
Sbjct: 681 RERL-----QRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 231 AEATNAELER---KLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEE 287
E + L+ +LQ+R GELQ EA SR +D L + ++ + + K EE
Sbjct: 736 REQSLDALQTHYDELQARLGELQG-EAASR---EDTICLLQNEKIILEAALQAAKSGKEE 791
Query: 288 LDRLAR-------------EKDAVLVAVKGAHVEQLQELQTRVLELQAHC---ETLEAQL 331
LDR AR EK +A+K VE LQ+ +T L+ Q + L+ ++
Sbjct: 792 LDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ-ETAALKKQMQKIKEQFLQQKV 850
Query: 332 RRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKL 391
+R+ T+K DQL + + D+++ +L +E++ + +T + E +L
Sbjct: 851 MVEAYRRDATSK------DQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRL 904
Query: 392 KAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQG 451
+VA+ +Q + + L A + ERD+++ L ++ D+ ++ A+ +
Sbjct: 905 HREVAQVRQHMADLEGHLQSAQK-----ERDEMETHLQ------SLQFDK-EQMVAVTEA 952
Query: 452 LSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEE 511
K Q+ QE +A+ EQ +Q
Sbjct: 953 NEALKKQIEELQQEARKAITEQ--------------------------------KQKMRR 980
Query: 512 ISKDFPSSEIQRLREQNTSLRNAIAQM-RKEMEALSHQIPPPIQTAAESTDANQPDPEAG 570
+ D S++ + ++ ++ + NA+ + R+ EAL+ A E+ DA A
Sbjct: 981 LGSDLTSAQ-KEMKTKHKAYENAVGILSRRLQEALA---------AKEAADAELGQLRAQ 1030
Query: 571 GDAATPDYVL-----ALEAEIRTLKHKFKTLEKHLEDVL------------------DPL 607
G ++ L ALEAE++ + H LEK L++V+ D L
Sbjct: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL 1090
Query: 608 KMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRV 667
+ S + + S + + + G GQ+ +++ AL K +
Sbjct: 1091 QESRGFRKKIKRLEESNKKLALELE-HEKGKLTGLGQSNAALREHNSILETALAKREADL 1149
Query: 668 QLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVA----ELGKHLRIA 723
LNL V + Q+ E + L + L +++ +V L++QVA E G + R
Sbjct: 1150 VQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHF 1209
Query: 724 QHGGAEPSG-RKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRL 775
+ E S +K+ A + + + ++ D+ R GKH AQ + L
Sbjct: 1210 KAASLELSEVKKELQAKEHLV---QKLQAEADDLQIRE-GKHSQEIAQFQAEL 1258
Score = 86.7 bits (213), Expect = 9e-17
Identities = 146/644 (22%), Positives = 284/644 (44%), Gaps = 82/644 (12%)
Query: 18 EEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEER-DLELERYDA 76
++E AL+ +++E LQ + + EA + ++ + L+ +R D EL+
Sbjct: 828 QQETAALKKQMQKIKEQFLQ--QKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQ 885
Query: 77 AFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHS 136
Q + AE+S L E A++RQ +A ++ Q+++ E L+ +
Sbjct: 886 ELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERD----EMETHLQSLQF 941
Query: 137 DKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNM 196
DK ++ E E LK +E +E + Q+Q++ S + + E + +
Sbjct: 942 DKE-QMVAVTEANEALKKQIEELQQEARKAITEQKQKMR-RLGSDLTSAQKEMKTKHKAY 999
Query: 197 SNTA--LSRELKVKLLHKE-----LEALKEAGAKAAESL---QRAEATNAELERKLQSRA 246
N LSR L+ L KE L L+ G + SL +R +A AEL+ S+
Sbjct: 1000 ENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKT 1059
Query: 247 ---GELQDLEAM-------SRARVKDLEDKLHSVQLTRKKE---EETFKRKHEELDR--- 290
ELQ++ A+ SR +V +LED+L + RKK EE+ K+ EL+
Sbjct: 1060 LLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKG 1119
Query: 291 ----------LAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRR-AEWRQA 339
RE +++L L +L +V + E + Q++ + QA
Sbjct: 1120 KLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQA 1179
Query: 340 DTAKEKDAAIDQLREDASTVK----------SAWDAQIAQLSKEMVSRDLQIQTLQEEEV 389
KEK+ ++ L+E + K A +++++ KE+ +++ +Q LQ E
Sbjct: 1180 SLEKEKEK-VNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEAD 1238
Query: 390 KLKAQVARSQQDIERYKQQLSLAVERERSLER---DQVQLGLDWQRRCDDIERDQIQKSE 446
L+ + + Q+I +++ +L+ A + + L++ +Q+ + ++++ + QK E
Sbjct: 1239 DLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQK-E 1297
Query: 447 ALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLR 506
IQ L K Q+ Q+ + L+ + +L+ V E + A + L M + +L+
Sbjct: 1298 REIQSL---KQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSM----TQKDKFMLQ 1350
Query: 507 QHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEM--EALSHQIPPPIQ------TAAE 558
E+ K+ + +Q+ ++ LR A+ RKE EA S PI+ A+
Sbjct: 1351 AKVSEL-KNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASL 1409
Query: 559 STDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLED 602
+ +P P A + + + L + ++ LK + +L++ +E+
Sbjct: 1410 LEELLRPPP-----AVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
Score = 82.8 bits (203), Expect = 1e-15
Identities = 125/607 (20%), Positives = 250/607 (41%), Gaps = 57/607 (9%)
Query: 33 EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEV 92
+AA + + Q +E G++R + D + + LE E + Q + + ++
Sbjct: 366 QAAAAEHQDQGQEVNGEVRS-RRDSICSSVSLESSAAETQE---EMLQVLKEKMRLEGQL 421
Query: 93 SELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENL 152
L +EA+ QAL +A ELQ Q + + ++E HS + + D + + L
Sbjct: 422 EALSLEAS---QALKEKA----ELQAQLAALSTKLQAQVECSHSSQQRQ-DSLSSEVDTL 473
Query: 153 K---WTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQA--DNMSNTALSRELKV 207
K W LER + +L L + L E RL A ++M + LS++ V
Sbjct: 474 KQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTV 533
Query: 208 KLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAM------------ 255
L +++ AL+ LQ+ + L KL++ E+ L+++
Sbjct: 534 HDLRQQMTALQS-------QLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQ 586
Query: 256 -SRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQ 314
+R R++ + Q+T+ E K ++ L + E + KG QLQ ++
Sbjct: 587 EARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIE 646
Query: 315 TRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEM 374
+L+ +A ++ E +E + ++L+ A + S + Q+ Q+ +
Sbjct: 647 ADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASL-EQQLEQVKLTL 705
Query: 375 VSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRC 434
+ RD Q++ LQ+E + L Q+ +Q+ ++ +Q L L+ +L + R
Sbjct: 706 LQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRE 765
Query: 435 DDIERDQIQK--SEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALR 492
D I Q +K EA +Q K ++ + E+ +E L+ L + A+++ +
Sbjct: 766 DTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLE--KLREELAIKSGQ 823
Query: 493 MHGLPRPGAQMLLRQHEEEISKDFPSSE--IQRLREQNTSLRNAIAQMRKEMEALSHQIP 550
+ L + A L++ ++I + F + ++ R TS I++++ + L
Sbjct: 824 VEHLQQETA--ALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLD---- 877
Query: 551 PPIQTAAESTDANQPDPEAGGDAATPDYVLA-LEAEIRTLKHKFKTLEKHLEDVLDPLKM 609
+E + Q + G+ T + L+ L E+ ++ LE HL+
Sbjct: 878 ------SELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE 931
Query: 610 SSPHAES 616
H +S
Sbjct: 932 METHLQS 938
Score = 67.4 bits (163), Expect = 6e-11
Identities = 161/749 (21%), Positives = 307/749 (40%), Gaps = 118/749 (15%)
Query: 121 QLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFES 180
Q A EH+ + + V NGE+ R+ + L+ A ++E+L +
Sbjct: 366 QAAAAEHQDQGQEV----NGEVRSRRDSICSSV--------SLESSAAETQEEMLQVLKE 413
Query: 181 KMRKREHEFRLQADNMSNTALSRELKVKL--LHKELEALKEAGAKAAESLQRAEATNAEL 238
KMR L + EL+ +L L +L+A E + S QR ++ ++E+
Sbjct: 414 KMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVEC---SHSSQQRQDSLSSEV 470
Query: 239 ERKLQS-----RAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKR---KHEELDR 290
+ QS RA + DL+ M A+ L + +Q+ EE ++R K E++ R
Sbjct: 471 DTLKQSCWDLERA--MTDLQNMLEAKNASLASSNNDLQVA----EEQYQRLMAKVEDMQR 524
Query: 291 LAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAE-----------WRQA 339
KD + ++ +Q+ LQ+++ ++Q TL ++L+ ++ W Q
Sbjct: 525 SMLSKDNTVHDLR----QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQ 580
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQ---IAQLSKEMVSRDLQIQTLQEEEVKLKAQVA 396
A ++A + +L+ + + ++ Q + L E VS Q+ Q +K K ++A
Sbjct: 581 QLALAQEARV-RLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIA 639
Query: 397 RSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIE--RDQIQK----SEALIQ 450
Q IE A + ++ + + D QRR ++ E R+++Q+ + +L Q
Sbjct: 640 AQLQGIEADMLDQEAAFMQ---IQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQ 696
Query: 451 GLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEE 510
L K + + Q+ E QE ++K +TL ++ A+Q+ R + L+ H +
Sbjct: 697 QLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE-ALQS-------REQSLDALQTHYD 748
Query: 511 EISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAG 570
E+ + + L+ + S + I ++ E L + A ++ + + + + G
Sbjct: 749 ELQ-----ARLGELQGEAASREDTICLLQNEKIIL--------EAALQAAKSGKEELDRG 795
Query: 571 GDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE--SQPSVRTSTETTG 628
R L+ + + LE + + L + S E Q + +
Sbjct: 796 A---------------RRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
Query: 629 GSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEP 688
Q Q V+A + + + +S A RK L+ + LRQ++++ E
Sbjct: 841 IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKR------LDSELKELRQELMQVHGEK 894
Query: 689 AALQRELPREVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASD-----AVA 743
+ EL R +H EV ++R+ +A+L HL+ AQ E Q D AV
Sbjct: 895 RTAEAELSR----LHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVT 950
Query: 744 LGREDAKSAEDEAPS---RHLGKHQPRSAQVGSRLDALQGP-KTQHSIH--TVTCKSPRQ 797
E K +E + + + + + ++GS L + Q KT+H + V S R
Sbjct: 951 EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
Query: 798 KEDRSPKPPQAPQHPEEHGRQSHSSSSFA 826
+E + K + + + S SS A
Sbjct: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLA 1039
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 92.4 bits (228), Expect = 2e-18
Identities = 168/770 (21%), Positives = 321/770 (41%), Gaps = 139/770 (18%)
Query: 17 KEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDA 76
+E+E +++ T+L+EA LE+++ + + L+E V LQ E+ DL+L+
Sbjct: 845 REKEMASMKEEFTRLKEA--------LEKSEARRKELEEKMVSLLQ--EKNDLQLQ---- 890
Query: 77 AFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHS 136
QA E+ A+ E + K + L + +++ E RLE E
Sbjct: 891 --VQA---EQDNLADAEERCDQLIKNKIQLEAKVKEMNE------------RLEDE---E 930
Query: 137 DKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNM 196
+ N E+ + + E+ L+R +++L+ LA K+ K +H + N+
Sbjct: 931 EMNAELTAKKRKLEDECSELKRDIDDLELTLA------------KVEKEKHATENKVKNL 978
Query: 197 SNTALSRELKVKLLHKELEALKEAGAKAAESLQRAE---ATNAELERKLQSRAGELQ-DL 252
+ + + L KE +AL+EA +A + LQ E T + + KL+ + +L+ L
Sbjct: 979 TEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSL 1038
Query: 253 EAMSRARVKDLEDKLHSVQLTRKKEEET---FKRKHEELDRLAREKDAVLVAVKGAHVEQ 309
E + R+ DLE ++ K +E+ + ++LD ++KD L A+ A +E
Sbjct: 1039 EQEKKVRM-DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL-NARIED 1096
Query: 310 LQ----ELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDA 365
Q +LQ ++ ELQA E LE +L +A K + +L E + ++ A A
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Query: 366 QIAQLSK--------EMVSRDLQIQTLQEEEVKLK---------AQVARSQQDIERYKQQ 408
Q+ + + RDL+ TLQ E A++ +++R KQ+
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 409 LSLAVERERS---LERDQVQLGLD--------WQRRCDDIE------RDQIQKSEALIQG 451
L E+E+S LE D V ++ ++ C +E R + ++++ +
Sbjct: 1217 L----EKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272
Query: 452 LSMAKSQVAAKLQETEQALQEQEVVLKAVT----------------LERDQAVQALRMHG 495
L+ ++++ + E + L E+E ++ +T LE + + H
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 496 L--PRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPI 553
L R +L Q+EEE +E+QR+ + S +AQ R + E + Q +
Sbjct: 1333 LQSARHDCDLLREQYEEETE---AKAELQRVLSKANS---EVAQWRTKYETDAIQRTEEL 1386
Query: 554 QTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPH 613
+ A + + E + V A+ A+ +L+ L+ +ED++ ++ S+
Sbjct: 1387 EEAKKKLAQRLQEAE--------EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 614 AESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLL 673
A + + + + A+ Q Q+ +A +S+ L K L +L
Sbjct: 1439 AAALDKKQRNFDKI--LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 674 VTRLRQKVLREPLEPAALQ--------RELPREVDQVHLEVLELRKQVAE 715
+ K L+E + Q EL + Q+ E +EL+ + E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546
Score = 88.2 bits (217), Expect = 3e-17
Identities = 125/582 (21%), Positives = 237/582 (40%), Gaps = 86/582 (14%)
Query: 10 LNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDL 69
L+E L +K+ E AL A R + ++A + +L+E Q ++ L+E+ L
Sbjct: 1076 LDERLKKKDFELNALNA-RIEDEQALGSQLQKKLKELQARIEELEEE------------L 1122
Query: 70 ELERYDAAFAQ------AREWEE-ARRAE----VSELKIEAAKLRQALAREARKVEELQQ 118
E ER A + +RE EE + R E + ++IE K R+A E +K+ +
Sbjct: 1123 EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA---EFQKMRRDLE 1179
Query: 119 QQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGEL--ALQRQELLL 176
+ L + L + H+D E+ + + +K LE++ E EL E ++
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 177 EFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNA 236
+ ++ + K Q + + A + V L + L+ + + L EA +
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Query: 237 ELERKLQSRAGELQDLEAMSRARVK-------DLEDKLHSVQLTRKKEEETFKRKHEELD 289
+L R + +L+DL+ VK L+ H L R++ EE + K E
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1359
Query: 290 RLAR------------EKDAV-----LVAVKGAHVEQLQELQTRVLELQAHCETLEAQLR 332
L++ E DA+ L K ++LQE + V + A C +LE
Sbjct: 1360 VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419
Query: 333 RAEWRQADTAKEKD------AAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQE 386
R + D + + AA+D+ + + + + W + + E+ S + ++L
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 387 EEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSE 446
E KLK S + +E +K++ ++L+ + L +Q+ S
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRE-------NKNLQEEISDL------------TEQLGSSG 1520
Query: 447 ALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLR 506
I L + Q+ A+ E + AL+E E L+ E + ++A + + L
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQLEFNQIKAEIERKLA 1577
Query: 507 QHEEEISKDFPS-----SEIQRLREQNTSLRNAIAQMRKEME 543
+ +EE+ + + +Q + T RN +++K+ME
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME 1619
Score = 82.0 bits (201), Expect = 2e-15
Identities = 147/702 (20%), Positives = 293/702 (41%), Gaps = 69/702 (9%)
Query: 33 EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEV 92
E + + RS+ EE Q + L E +L+ +A +Q + ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 93 SELKI---EAAKLRQALA---REARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHR 146
+LK E K + ALA + AR +L ++Q E + EL+RV S N E+ R
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 147 EQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELK 206
+YE A+QR E L E + K+ +R E + ++ S E
Sbjct: 1373 TKYET---------------DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 207 VKLLHKELEAL------KEAGAKAAESLQR-AEATNAELERKLQSRAGELQDLEAMSRAR 259
L E+E L A A A + QR + AE ++K + EL+ + +R+
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 260 VKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLE 319
+L KL + + ETFKR+++ L +E+ + L G+ + + EL+ +
Sbjct: 1478 STEL-FKLKNAYEESLEHLETFKRENKNL----QEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 320 LQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDL 379
L+A L++ L AE + + ++ I + + + + +K A++ +++ +D
Sbjct: 1533 LEAEKMELQSALEEAE----ASLEHEEGKILRAQLEFNQIK-------AEIERKLAEKDE 1581
Query: 380 QIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIER 439
+++ + +++ ++ D E + +L V+++ + +++++ L R +
Sbjct: 1582 EMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 440 DQIQKSEALIQGLSMAKSQVAAKLQETEQ--ALQEQEVVLKAVTLERDQAV--QALRMHG 495
Q++ ++L++ + + ++ A+ E+ L LE +AV Q R
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1700
Query: 496 LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQT 555
L E+E+ + S +Q L QNTSL N +M ++ L ++ +Q
Sbjct: 1701 LA-----------EQELIE--TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ- 1746
Query: 556 AAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAE 615
E +A + +A DAA L+ E T H + ++K++E + L+ AE
Sbjct: 1747 --ECRNAEEKAKKAITDAAM--MAEELKKEQDTSAH-LERMKKNMEQTIKDLQHRLDEAE 1801
Query: 616 SQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQA-GPVSSGLALRKLGDRVQLLNLLV 674
+ A+ + ++A Q + G S +++L + + +
Sbjct: 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL 1861
Query: 675 TRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAEL 716
RL+ V + L+ A +R+ +Q + + + RK EL
Sbjct: 1862 LRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Score = 73.6 bits (179), Expect = 8e-13
Identities = 86/361 (23%), Positives = 161/361 (44%), Gaps = 33/361 (9%)
Query: 205 LKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRA---RVK 261
LK KE+ ++KE + E+L+++EA ELE K+ S E DL+ +A +
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 262 DLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQ 321
D E++ + + + E K +E L+ E +A L A K ++ EL+ + +L+
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 322 AHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQI 381
+E + + A + E+ A +D++ + K A Q ++ + + ++
Sbjct: 959 LTLAKVEKE-KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 382 QTLQEEEVKLKAQV----------ARSQQDIERYKQQ----LSLAVERERSLERDQVQLG 427
TL + +VKL+ QV + + D+ER K++ L L E LE D+ Q
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ-- 1075
Query: 428 LDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQA 487
LD + + D E + + A I+ SQ+ KL+E + ++E E L+A ER
Sbjct: 1076 LDERLKKKDFELNAL---NARIEDEQALGSQLQKKLKELQARIEELEEELEA---ERTAR 1129
Query: 488 VQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSH 547
+ ++ R L + E + + ++ +Q E N +MR+++E +
Sbjct: 1130 AKVEKL----RSDLSRELEEISERLEEAGGATSVQ--IEMNKKREAEFQKMRRDLEEATL 1183
Query: 548 Q 548
Q
Sbjct: 1184 Q 1184
Score = 44.7 bits (104), Expect = 4e-04
Identities = 61/298 (20%), Positives = 132/298 (44%), Gaps = 46/298 (15%)
Query: 23 ALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYN---LQVLEERDLEL----ERYD 75
A+ R L +A L++ R+ +E+ + + +++ + +Q+L ++ L ++ D
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 76 AAFAQAR-EWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERV 134
A +Q + E EEA V E + K ++A+ A EEL+++Q
Sbjct: 1732 ADLSQLQTEVEEA----VQECRNAEEKAKKAITDAAMMAEELKKEQ-------------- 1773
Query: 135 HSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQAD 194
D + ++ ++ E L+ +L+E + ++ L + E+++R+ E+E L+A+
Sbjct: 1774 --DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE--LEAE 1829
Query: 195 NMSNTALSRELKVKLLHKELEALKEAGAKAAE---SLQRAEATNAELERKLQSRAGELQD 251
N VK + K +KE + E +L R + +L+ K+++ + ++
Sbjct: 1830 QKRNAE-----SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Query: 252 LEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRL-AREKDAVLVAVKGAHVE 308
E + + K VQ + EE ++++L A+ +D + KG + E
Sbjct: 1885 AEEQANTNL----SKFRKVQHELDEAEERADIAESQVNKLRAKSRD---IGTKGLNEE 1935
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 92.0 bits (227), Expect = 2e-18
Identities = 160/763 (20%), Positives = 299/763 (39%), Gaps = 117/763 (15%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE 66
+P L KE RT+ + A + R +LEE L + D +Q E
Sbjct: 841 KPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE 900
Query: 67 RDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQE 126
++ E +++ EA+ E++E E ++ L + R +E+ + +
Sbjct: 901 NLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD 960
Query: 127 HRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKRE 186
L L +V +K+ E K++ L E+ + + SK+ K +
Sbjct: 961 LELTLTKVEKEKH---------------ATENKVKNLSEEMTALEENI-----SKLTKEK 1000
Query: 187 HEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRA 246
+ + E KV L K L++ SL++ + A+LER +
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 247 GELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAH 306
G+L+ MS+ + DLE+ +++ EE K+K EL +L + D
Sbjct: 1061 GDLK----MSQESIMDLEN-------DKQQIEEKLKKKEFELSQLQAKID-------DEQ 1102
Query: 307 VEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQ 366
V LQ Q ++ ELQA E LE ++ +A K++ +L E + ++ A A
Sbjct: 1103 VHSLQ-FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 367 IAQLSK--------EMVSRDLQIQTLQEEEVKLKAQVARSQQD-IERYKQQLSLAVERER 417
AQ+ + + RDL+ TLQ E A + + Q D + +Q+ ++
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEAT--AATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 418 SLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVL 477
LE+++ +L ++ DD+ + I+ LS +KS + + T + +++Q +
Sbjct: 1220 KLEKEKSELKME----IDDMASN--------IEALSKSKSNI----ERTCRTVEDQFSEI 1263
Query: 478 KAVTLERDQAVQALRMH--GLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAI 535
KA ++ Q + L M L ++ R E+E + Q L +Q L+ +
Sbjct: 1264 KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 536 AQMRKEMEALSHQIPPPIQTAAESTD--ANQPDPEAGGDAATPDYVLALEAEIRTLKHKF 593
+ K A++H +Q++ D Q + E A + +E+ + K+
Sbjct: 1324 EEETKAKNAMAH----ALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY 1379
Query: 594 KT--------LEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQA 645
+T LE+ + + L+ + + E+ S S E T Q G V+
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ-----GEVE---- 1430
Query: 646 GGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRE----------- 694
+ S A L + + + ++ +QK+ E A Q+E
Sbjct: 1431 --DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 695 -------------LPREVDQVHLEVLELRKQVAELGKHLRIAQ 724
L RE + E+ +L +Q+AE GK+L+ A+
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE 1531
Score = 76.6 bits (187), Expect = 1e-13
Identities = 135/625 (21%), Positives = 246/625 (39%), Gaps = 106/625 (16%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY 74
++ ++E + H +Q+A LQ +L + L + Q L ++ EL+R
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR- 1321
Query: 75 DAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERV 134
Q E +A+ A L+ +R +L ++Q QE + EL+R
Sbjct: 1322 -----QMEEETKAKNAMAHALQ------------SSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 135 HSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQAD 194
S N E+ R +YE +LEE +LA + QE E+ K
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSK--------CA 1416
Query: 195 NMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEA 254
++ T + +V+ L ++LE A A + + + AE ++KL EL+ +
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 255 MSRA----------RVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKG 304
SR+ +++ D+L +++ K +E E++ + K
Sbjct: 1477 ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKL 1536
Query: 305 AHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK-------EKDAAIDQLRED-- 355
E+ +LQ + E++ E E+++ R + + EKD I+QL+ +
Sbjct: 1537 VEQEK-SDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 356 --ASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKL---KAQVARSQQDIERYKQQLS 410
A ++S DA+I + + + L E E++L Q+A +Q+ + + QL
Sbjct: 1596 RAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 411 LAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQAL 470
QL LD D ++ +E L + L++ + + L+E L
Sbjct: 1656 ------------DSQLHLD----------DALRSNEDLKEQLAIVERRNGLLLEE----L 1689
Query: 471 QEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTS 530
+E +V L+ R R E+E+ S +Q L QNTS
Sbjct: 1690 EEMKVALEQTERTR---------------------RLSEQELLD--ASDRVQLLHSQNTS 1726
Query: 531 LRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLK 590
L N ++ ++ ++ IQ ES +A + +A DAA L+ E T
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQ---ESRNAEEKAKKAITDAAM--MAEELKKEQDTSA 1781
Query: 591 HKFKTLEKHLEDVLDPLKMSSPHAE 615
H + ++K+LE + L+ AE
Sbjct: 1782 H-LERMKKNLEQTVKDLQHRLDEAE 1805
Score = 71.2 bits (173), Expect = 4e-12
Identities = 108/481 (22%), Positives = 208/481 (43%), Gaps = 60/481 (12%)
Query: 176 LEFESKMRKREHEFRLQADNMSNTALSRE------LKVKLL------HKELEALKEAGAK 223
+EF+ M +R+ F +Q + S + K+K L KE+ +KE +
Sbjct: 803 VEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFER 862
Query: 224 AAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKR 283
E L R+EA ELE K+ S E DL+ ++ ++L D + K + +
Sbjct: 863 TKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK 922
Query: 284 KHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK 343
E +RL E+ E EL + L+ C +L+ + E K
Sbjct: 923 VKELTERLEEEE------------EMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 344 EKDAAIDQLREDASTVKSAWDAQIAQLSKEMVS----RDLQIQTLQEEE------VKLKA 393
EK A ++++ + S +A + I++L+KE S + LQ EE +K+ A
Sbjct: 971 EKHATENKVK-NLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINA 1029
Query: 394 QVARSQQDIE-RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGL 452
++ + D+E +Q+ L + ER+ + + L + Q D+E D+ Q+ E ++
Sbjct: 1030 KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS-QESIMDLENDK-QQIEEKLKKK 1087
Query: 453 SMAKSQVAAKLQETE-QALQEQEVV--LKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
SQ+ AK+ + + +LQ Q+ + L+A E ++ ++A H L + + +
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEA--EHTL-----RAKIEKQR 1140
Query: 510 EEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAA---ESTDANQPD 566
+++++ EI E+ + +A +M K+ EA ++ ++ A E+T A
Sbjct: 1141 SDLAREL--EEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 567 PEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTET 626
+A D V L +I L+ + LEK ++ + + + E+ +++ E
Sbjct: 1199 KQA-------DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251
Query: 627 T 627
T
Sbjct: 1252 T 1252
Score = 42.4 bits (98), Expect = 0.002
Identities = 61/298 (20%), Positives = 120/298 (40%), Gaps = 13/298 (4%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQ--EAALQDTRSQLEEAQGKLRCLQEDFVYNLQVL 64
E LNE+ ++ R + + L+ + L+D++ L++A LR ED L ++
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDA---LRS-NEDLKEQLAIV 1678
Query: 65 EERD-LELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLA 123
E R+ L LE + + E RR EL ++A+ Q L + + +++ +
Sbjct: 1679 ERRNGLLLEELEEMKVALEQTERTRRLSEQEL-LDASDRVQLLHSQNTSLINTKKKLEAD 1737
Query: 124 FQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESK-- 181
+ + E+E + + ++ + E +E D L+R + LE K
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Query: 182 MRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERK 241
+ + +L E +V+ L EL+ ++ GA+A + + E E+ +
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQ 1857
Query: 242 LQS---RAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKD 296
+ LQDL +A+VK + + + + +R EL+ A D
Sbjct: 1858 AEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERAD 1915
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1516 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1809
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1810 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1918
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1919 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1973
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1974 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2020
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2080 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2118
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2119 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2236 QMEELSK 2242
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2090
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2091 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2268 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2320
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2381 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2497 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2544
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2605 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2634
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2635 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2693 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2720
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1369
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1426
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1545
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1844
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1845 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1902 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1958
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1103 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1338 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1445
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 980 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1038
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1039 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1138
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1520 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1813
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1814 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1922
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1923 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1977
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1978 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2024
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2084 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2122
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2123 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2179
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2240 QMEELSK 2246
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2094
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2095 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2153 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2272 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2324
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2385 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2501 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2548
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2609 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2638
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2639 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2696
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2697 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2724
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1373
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1374 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1430
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1549
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1609
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1610 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1848
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1849 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1906 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1962
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1107 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1166
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1342 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1449
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1568
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 984 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1042
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1043 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1101
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1102 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1142
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1516 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1809
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1810 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1918
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1919 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1973
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1974 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2020
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2080 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2118
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2119 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2236 QMEELSK 2242
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2090
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2091 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2268 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2320
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2381 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2497 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2544
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2605 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2634
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2635 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2693 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2720
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1369
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1426
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1545
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1844
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1845 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1902 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1958
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1103 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1338 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1445
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 980 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1038
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1039 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1138
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1484 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1777
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1778 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1886
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1887 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1941
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1942 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 1988
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2048 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2086
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2087 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2143
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2204 QMEELSK 2210
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2058
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2059 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2117 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2236 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2288
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2349 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2465 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2512
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2573 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2602
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2603 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2660
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2661 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2688
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1337
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1338 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1394
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1513
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1573
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1574 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1812
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1813 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1870 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1926
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1071 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1130
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1131 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1190
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1306 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1413
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1532
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 948 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1006
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1007 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1065
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1066 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1106
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1653 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1946
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1947 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 2055
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 2056 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 2110
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 2111 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2157
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2217 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2255
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2256 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2312
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2373 QMEELSK 2379
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2227
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2228 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2286 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2405 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2457
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2518 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2634 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2681
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2742 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2771
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2772 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2829
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2830 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2857
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1506
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1507 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1563
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1682
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1742
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1743 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1981
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1982 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 2039 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 2095
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1240 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1299
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1300 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1359
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1475 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1582
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1701
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 1117 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1175
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1176 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1275
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1494 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1787
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1788 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1896
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1897 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1951
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1952 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 1998
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2058 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2096
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2097 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2153
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2154 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2214 QMEELSK 2220
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2068
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2069 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2127 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2246 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2298
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2359 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2475 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2522
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2583 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2612
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2613 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2670
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2671 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2698
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1347
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1348 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1404
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1523
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1583
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1584 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1822
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1823 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1880 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1936
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1316 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1423
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1542
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 958 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1016
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1017 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1116
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1502 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1795
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1796 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1904
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1905 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 1959
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 1960 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2006
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2066 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2104
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2105 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2161
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2162 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2222 QMEELSK 2228
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2076
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2077 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2135 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2254 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2306
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2367 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2483 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2530
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2591 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2620
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2621 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2678
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2679 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2706
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1355
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1356 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1412
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1531
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1591
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1592 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1830
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1831 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1888 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1944
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1089 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1148
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1149 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1208
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1324 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1431
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1550
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 966 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1024
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1025 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1083
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1084 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1124
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 92.0 bits (227), Expect = 2e-18
Identities = 184/787 (23%), Positives = 330/787 (41%), Gaps = 140/787 (17%)
Query: 12 ELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEE----- 66
EL R + E A + + LQ AL++ R Q EEA+ +LR + + +QV E
Sbjct: 1543 ELASRVKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 67 RDLELERYDAAFAQ--------------------------AREWEEARRA-EVSELKIEA 99
+ EL+ A+FA+ A++ EA RA E +E ++E
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Query: 100 AKLRQALAREAR-KVEELQQQQQLAFQEHRLELERVHSD--KNGEIDHHR-EQYENLKWT 155
+L+ A R + EE+ QQ+ LA E + E + + G+ + Q E +
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
Query: 156 LERKLEELDG----ELALQRQELLLEFESKMRKREHEF------RLQADNMSNTALSREL 205
LE++ + +G LA +++ + L E++ +++ + RLQ + + T +EL
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 206 KVKL--LHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDL 263
+ +L + E+E L + A+A E + +T+ + +++L++ AG ++L A AR++ L
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRLEAEAGRFREL-AEEAARLRAL 1836
Query: 264 EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDA-------------VLVAVKGAHVEQL 310
++ + R+ EE R+ E +R+ EK A + + K A E+L
Sbjct: 1837 AEE---AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 311 QEL------QTRVLELQAHCETLEAQLRRAEWRQA---DTAKEKDAAIDQLREDASTVKS 361
+ L Q R LE QA + + R A+ R+A + ++K D LR
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-------- 1945
Query: 362 AWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVAR---SQQDIERYKQQLSLAVERERS 418
Q Q+ +E+++ + + +L+ ++ R + +D R K+Q L R+R
Sbjct: 1946 ----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR- 2000
Query: 419 LERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLK 478
QL + +RR + E +++QKS A + A Q A L+E E+ + E +
Sbjct: 2001 ------QLAAEEERRRREAE-ERVQKSLAAEE---EAARQRKAALEEVERLKAKVE---E 2047
Query: 479 AVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQM 538
A L ++ R L + AQ L Q EE+ + Q L++ ++ + Q+
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRL-QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 539 RKEMEALSHQIPPPIQTAAESTDAN-QPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLE 597
R E EA + A E+ +A Q + EA A+ R + + L+
Sbjct: 2107 RGEAEAAR-------RAAEEAEEARVQAEREA--------------AQSRRQVEEAERLK 2145
Query: 598 KHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSG 657
+ E+ + AE +R E + Q A ++ +
Sbjct: 2146 QSAEEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2202
Query: 658 LALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQR------ELPREVDQVHLEVLELRK 711
LR+ Q L L +L + ++ L LQR E R+ QV E+ +R
Sbjct: 2203 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 712 QVAELGK 718
Q+ EL K
Sbjct: 2263 QMEELSK 2269
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/752 (24%), Positives = 305/752 (40%), Gaps = 125/752 (16%)
Query: 2 LPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNL 61
L L E A L ++ A+Q +LQ+ LQ +S L++ +G+ +
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEAEAARRA----A 2117
Query: 62 QVLEERDLELERYDAAFAQAREWEEARRAEVS-ELKIEAAKLRQALAREARKVEELQ--- 117
+ EE ++ ER A R+ EEA R + S E + +A QA A + RK E +
Sbjct: 2118 EEAEEARVQAER--EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 118 --QQQQLAFQEHRL---ELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELAL--- 169
Q +Q A ++ + E+E+ H + + Q E TL +LEE D + L
Sbjct: 2176 RAQAEQAALRQKQAADAEMEK-HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 170 QRQELLLEFESKMRKREH------------------EFRLQADNMSNTALSRELKVKLLH 211
+ Q L E R+R + R++A+N + ++ + L
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294
Query: 212 KELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQ 271
+E E +K+ +AA R E R Q +L A++ K L++K+ +VQ
Sbjct: 2295 EEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAE---KMLKEKMQAVQ 2347
Query: 272 -LTRKKEEETFKRKHEELD-----RLAREKDAV---LVAVKGAHVEQLQELQTRVLELQA 322
TR K E ++ +EL RL +K+ + L L+ + R LE+ A
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 323 HCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTV-KSAWDAQIAQLSKEMVSRDLQI 381
E L+ LR AE +A E+DA + R+ A + + ++A K + + L+I
Sbjct: 2408 EAERLK--LRVAEMSRAQARAEEDA--QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 382 QTLQEEE--VKLKAQVARSQQDIERYKQQ---LSLAVERERSLERDQVQLGLDWQRRCDD 436
Q Q + +L+ +A +++ E+ +Q+ L L E ++++++Q+ ++
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 437 IERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHG- 495
E+D + + E I+ Q AKL EQ Q++ V KA L +Q Q +M
Sbjct: 2524 SEKDSLLQRERFIE-------QEKAKL---EQLFQDE--VAKAQQLREEQQRQQQQMEQE 2571
Query: 496 ---LPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQ----MRKEMEALSHQ 548
L + RQHE E E+Q+L +Q +A+ +R++++ L Q
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Query: 549 IPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLK 608
+ + E T A AAT KTL D LD
Sbjct: 2632 HRAALAHSEEVT--------ASQVAAT------------------KTLPNG-RDALD--- 2661
Query: 609 MSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRK-----L 663
P AE++P SAQ Q G + A + Q LA R+ L
Sbjct: 2662 --GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2719
Query: 664 GDRVQLLNLLVTRLRQKVLREPLEPAALQREL 695
R + LL+ +K+ AALQR+L
Sbjct: 2720 QGRSSIAGLLLKATNEKL----SVYAALQRQL 2747
Score = 86.7 bits (213), Expect = 9e-17
Identities = 184/835 (22%), Positives = 356/835 (42%), Gaps = 91/835 (10%)
Query: 19 EEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAF 78
+E+ L+ H ++L Q + E + R +E+ + Q EER+ L +AA
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERE-RLAEVEAAL 1396
Query: 79 AQAREWEEARRAEVSELKIEAAKLRQALAREARKVEEL---QQQQQLAFQEHRLELERVH 135
+ R+ EA ++ + EA +L+Q + E + EE QQQ+ + QE EL+++
Sbjct: 1397 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE---ELQQLR 1453
Query: 136 SDKNGEIDHHREQYENLKWTLERKLEEL-----------------DGELALQRQELLLEF 178
EI Q E + + R EE+ +GEL R
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513
Query: 179 ESKMRKREHEFRLQADNMSNTALSRELKVKLLHK---ELEALKEAGAKAAESLQRAEATN 235
K + +E RL+ + R+ +V+L + E EA +E +A ++L+
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQA 1572
Query: 236 AELERKLQ----SRAGELQ-DLEAMSRARVKDLEDKLHS-----VQLTRKKEEE--TFKR 283
E ER+L+ RA ++Q LE R+ +L+ K S QL R +EE +
Sbjct: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1632
Query: 284 KHEELDRLAREKDAVLVAVKGAHVE----QLQELQTRVLELQAHCETLEAQLRRAEWRQA 339
EE +R A+++ A + A E QL+ + L LQA + L +AE +
Sbjct: 1633 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
Query: 340 DTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEE-VKLKAQVARS 398
E++A E+ + + Q + +++ Q + E+E ++L+A+ +
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 399 QQ-------DIERYKQQLSLAVERERSLE------RDQVQLGLDWQRRCDDIERDQIQKS 445
+Q ++ R +++ + A ++ + LE R ++++ L + R ++ R +KS
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 446 EALIQ---GLSMAKSQVAAKLQE-TEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGA 501
+ ++ G ++ AA+L+ E+A +++++ + +R +A + L L G
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-AEKLAAIGE 1871
Query: 502 QMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQ--IPPPIQTAAES 559
L+ E EI+ +E +RLR + A + R E +A H+ I + ++
Sbjct: 1872 ATRLKT-EAEIALKEKEAENERLR--RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 560 TDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPS 619
+D ++ + + G T +E EI LK F+ ++ L++ + ++ +
Sbjct: 1929 SD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDT 1985
Query: 620 VRTSTETTGGSAQAGQAGGSVQ--AGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRL 677
+R+ + +A+ Q + +A VQ + A R+ ++ + L ++
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 678 RQ-KVLREPLE-PAALQRELPREVDQVHLEVLE------LRKQVAELGKHLRIAQ----- 724
+ + LRE E +A Q +L +E Q L+ E ++++ EL + L+ Q
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 725 -HGGAEPSGRKQPPASDA-VALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDA 777
G AE + R A +A V RE A+S + L + AQ ++ A
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Score = 80.9 bits (198), Expect = 5e-15
Identities = 133/583 (22%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 12 ELLLRKEEEWRALQAHRTQLQE-----AALQDTRSQLEEAQGKLRCLQEDFVYNLQVLE- 65
E+L EE+ + QA L E A+L+ R+Q E Q L+++ +V E
Sbjct: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189
Query: 66 ------ERDLELERYDAAFAQARE-WE------EARRAEVSELKIEAAKLRQ------AL 106
ERD+E+ER+ AQ E W+ + R+ E+ +L + R+ A
Sbjct: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249
Query: 107 AREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEEL-DG 165
++AR+ +E Q LA + E R EI+ H E+ E + ++ + + D
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
Query: 166 ELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAK-A 224
EL L + LE + K+ + + S + + + ++ + EL L K
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKP-----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 225 AESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRK 284
+E+L+R E E ER + + E R R+ ++E L + + + +
Sbjct: 1365 SETLRRME----EEERLAEQQRAE-------ERERLAEVEAALEKQRQLAEAHAQAKAQA 1413
Query: 285 HEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAK- 343
E L + +V + A V+ Q+ ++ ELQ ++ EA++ +A+ RQA+ A+
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAER 1472
Query: 344 -----EKDAAIDQLREDAS-TVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV-- 395
E++ + +L+ +A+ + + ++ L + Q + QEE +L+ QV
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1532
Query: 396 ---ARSQQDIE---RYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALI 449
+ Q ++E R K + A E++R+L+ + +L L + + + +++++ +
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQ 1591
Query: 450 QGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHE 509
L A+ A+LQ + E+ L+ E AV LR R Q +
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 510 EEISKD-----FPSSEIQRLR------EQNTSLRNAIAQMRKE 541
EE ++ ++E RLR Q SL A A+ +KE
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Score = 31.6 bits (70), Expect = 3.5
Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 21/161 (13%)
Query: 396 ARSQQDIERYKQ-QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSM 454
+R Q+ I K +L L R++ R ++ L + R C +Q QK++A ++GL
Sbjct: 1007 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVEGLGK 1065
Query: 455 AKSQVAAKLQETEQALQE---------QEVVLKAVTLERDQAVQALRMHGLPR------- 498
++++A+ ++ AL E E+ L LE+ +++ A+ + L
Sbjct: 1066 GVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124
Query: 499 -PGAQMLLRQHEEEISK-DFPSSEIQRLREQNTSLRNAIAQ 537
GA+ +LR HEE++ + + + L SL+ AQ
Sbjct: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1165
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 91.7 bits (226), Expect = 3e-18
Identities = 104/483 (21%), Positives = 225/483 (46%), Gaps = 32/483 (6%)
Query: 15 LRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERY 74
L KE + +L+ +R + + L++ ++L+E + + + N++ L+ + LER
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERA 254
Query: 75 DAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERV 134
Q + EA EL+ +AKL QA E L QQQ+ +++
Sbjct: 255 KLLLPQQQLQAEADHLG-KELQSVSAKL-QAQVEENELWNRLNQQQEEKMWRQEEKIQEW 312
Query: 135 HSDKNGEIDHHREQYENLKWTLE--RKLEEL--DGELALQRQE-LLLEFESKMRKREHEF 189
+ + REQ E ++ E R+ EE+ + E ++RQE ++ E E KMR+ E
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMM 372
Query: 190 RLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGEL 249
+ + + REL+ K+ H++ + ++ + E R + E E K+ + ++
Sbjct: 373 WEKEEKI------RELEEKM-HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 425
Query: 250 QDLEAMSRARVKDL---EDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAH 306
++ E R + K + E+K+H + R++E+ + + + RE++ + + H
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 307 V-EQLQELQTRVLELQAHCETLEAQLRRAE---WRQADTAKEKDAAI----DQLREDAST 358
E++++ + +V + E ++R E WRQ + +E++ I +++RE
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 359 VKSAWDAQIAQLSK--EMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERE 416
++ + Q K E Q + ++E+E K++ Q + ++ E+ +Q E+E
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQE 605
Query: 417 RSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVV 476
++ + ++ ++ C+ E+ Q Q+ + Q M + +V +L++ E+ +QE +
Sbjct: 606 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV--RLRQQEEKMQEHQEH 663
Query: 477 LKA 479
L+A
Sbjct: 664 LEA 666
Score = 78.2 bits (191), Expect = 3e-14
Identities = 114/562 (20%), Positives = 250/562 (44%), Gaps = 74/562 (13%)
Query: 7 EPALNELLLRKEEEWRALQAHRTQLQEAAL--QDTRSQLE-EAQGKLRCLQEDFVYN--- 60
+ AL L + R L +T+LQ A Q QLE EA+ + L + + +
Sbjct: 118 QEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL 177
Query: 61 ---LQVLEERDLELERYDAAFAQAREWE--EARRAEVS--ELKIEAAKLRQALAREARKV 113
L + + + +RY + R+ E R ++ ELK + AKL++ L + V
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL----QLV 233
Query: 114 EELQQQQQLAFQEHRLELERV-----HSDKNGEIDHHREQYENLKWTLERKLEE--LDGE 166
E + + QL +E + +LER E DH ++ +++ L+ ++EE L
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 167 LALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAE 226
L Q++E + E K+++ E + + Q + + +E K++ +++ +E + E
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE----QEEKIREQEEKMRRQEEMMWEKEE 349
Query: 227 SLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHE 286
++R E E E K++ L+++ ++++LE+K+H + R++EE KR+ E
Sbjct: 350 KMRRQEEMMWEKEEKMR----RLEEMMWEKEEKIRELEEKMHEQEKIREQEE---KRQEE 402
Query: 287 ELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKD 346
E R +EK A E+++E + ++ E + E ++ E + + +++
Sbjct: 403 EKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 461
Query: 347 AAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYK 406
+ + E + W + +E + + + QEE++ + + R Q++ + ++
Sbjct: 462 EEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE-KMWR 520
Query: 407 QQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQET 466
Q+ + + E+ E+++ +I++ E ++Q + K+ E
Sbjct: 521 QEEKIREQEEKIREQEE-----------------KIREQEEMMQ-------EQEEKMGEQ 556
Query: 467 EQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLRE 526
E+ +QEQE + + R+Q + + +R+ EE+I + + +++RE
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQ--------KEKIREQEEKIWE-----QEEKIRE 603
Query: 527 QNTSLRNAIAQMRKEMEALSHQ 548
Q ++ +M ++ E + Q
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQ 625
Score = 59.3 bits (142), Expect = 2e-08
Identities = 77/382 (20%), Positives = 163/382 (42%), Gaps = 48/382 (12%)
Query: 202 SRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVK 261
S E + K H+ EAL+ +++ EL+ L ++ LE +R +
Sbjct: 106 SPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 165
Query: 262 ----------DLEDKLHSVQLTRKKEEETFKRKHEELDRLARE------KDAVLVAVKGA 305
+LE L +V +KK + + +E D L+ E D L
Sbjct: 166 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 225
Query: 306 HVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDA 365
E+LQ +++ E+Q + + L+ +L RA+ ++ A D L ++ +V + A
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ--QQLQAEADHLGKELQSVSAKLQA 283
Query: 366 QI----------AQLSKEMVSRDLQIQ----TLQEEEVKLKAQVARSQQDIERYKQQLSL 411
Q+ Q ++M ++ +IQ +QE+E K++ Q + ++ E+ ++Q +
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
Query: 412 AVERERSLERDQVQLGLDWQ-----RRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQET 466
E+E + R + + W+ RR +++ ++ +K L + K K++E
Sbjct: 344 MWEKEEKMRRQEEMM---WEKEEKMRRLEEMMWEKEEKIRELEE-----KMHEQEKIREQ 395
Query: 467 EQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLRE 526
E+ QE+E + + ++Q + R R + + Q ++ ++ E +++RE
Sbjct: 396 EEKRQEEEKI-REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 527 QNTSLRNAIAQMRKEMEALSHQ 548
+ R +M ++ E + Q
Sbjct: 455 EEK--RQEQEEMWRQEEKIREQ 474
Score = 32.7 bits (73), Expect = 1.6
Identities = 51/300 (17%), Positives = 119/300 (39%), Gaps = 25/300 (8%)
Query: 268 HSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETL 327
H + ++ + + K + D + +V A +++ C +
Sbjct: 48 HPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSP 107
Query: 328 EAQLRRAEWRQADTAKEKDAAIDQLR----EDASTVKSAWDAQIAQLSKEMVSRDLQIQT 383
E + + + Q +E +A + +R + + + +Q A E +RDL I
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDL-ISR 166
Query: 384 LQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQ 443
L + K ++ ++ + K++ +E E + ERD + L L D+ +++
Sbjct: 167 LHDSW-KFAGELEQALSAVATQKKKADRYIE-ELTKERDALSLELYRNTITDEELKEKNA 224
Query: 444 KSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERD--------QAVQALRMHG 495
K + +Q + KS++ ++E ++ L+ +++L L+ + Q+V A
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 496 LPRPGAQMLLRQHEEEIS----------KDFPSSEIQRLREQNTSLRNAIAQMRKEMEAL 545
+ L Q +EE ++ + +++REQ +R +MR++ E +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,243,592
Number of Sequences: 37866
Number of extensions: 1644042
Number of successful extensions: 18748
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 1221
Number of HSP's that attempted gapping in prelim test: 10094
Number of HSP's gapped (non-prelim): 5103
length of query: 915
length of database: 18,247,518
effective HSP length: 111
effective length of query: 804
effective length of database: 14,044,392
effective search space: 11291691168
effective search space used: 11291691168
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.