Guide to the Human Genome
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Name: MTHFR Sequence: fasta or formatted (656aa) NCBI GI: 87240000
Description:

5,10-methylenetetrahydrofolate reductase

Referenced in:

Vitamin Pathways, Coenzymes, and 1-Carbon Metabolism

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.9         39           2
 C cysteine            1.7         11           2
 D aspartate           4.9         32           1
 E glutamate           9.6         63           4
 F phenylalanine       4.7         31           2
 G glycine             6.9         45           2
 H histidine           2.1         14           1
 I isoleucine          5.2         34           2
 K lysine              5.2         34           2
 L leucine             9.9         65           2
 M methionine          1.8         12           2
 N asparagine          4.6         30           1
 P proline             6.4         42           2
 Q glutamine           2.7         18           1
 R arginine            5.8         38           3
 S serine              6.9         45           3
 T threonine           4.6         30           2
 V valine              5.5         36           2
 W tryptophan          2.4         16           1
 Y tyrosine            3.2         21           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   5,10-methylenetetrahydrofolate reductase 
LPCAT4                0.006   lysophosphatidylcholine acyltransferase 4 
CCAR1                 0.005   cell-cycle and apoptosis regulatory protein 1 
PPP2R3B               0.005   protein phosphatase 2, regulatory subunit B'', beta ...
PPP2R3B               0.005   protein phosphatase 2, regulatory subunit B'', beta ...
PXDN                  0.005   peroxidasin 
PHRF1                 0.005   PHD and ring finger domains 1 
MYLK                  0.004   myosin light chain kinase isoform 3A 
MYLK                  0.004   myosin light chain kinase isoform 1 
MYLK                  0.004   myosin light chain kinase isoform 3B 
MYLK                  0.004   myosin light chain kinase isoform 2 
ZNF503                0.004   zinc finger protein 503 
HISPPD2A              0.004   histidine acid phosphatase domain containing 2A isof...
SDK2                  0.004   sidekick 2 
MAP4K4                0.004   mitogen-activated protein kinase kinase kinase kinas...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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