Search of human proteins with 86793109

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
         (2489 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...  5364   0.0  
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...  4204   0.0  
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...   778   0.0  
gi|148886654 polydom [Homo sapiens]                                   689   0.0  
gi|42544177 complement component (3d/Epstein Barr virus) recepto...   603   e-172
gi|54792123 complement component (3d/Epstein Barr virus) recepto...   603   e-172
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   410   e-113
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   410   e-113
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   397   e-110
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          354   7e-97
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    310   1e-83
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]           282   3e-75
gi|4502503 complement component 4 binding protein, alpha chain p...   221   7e-57
gi|157419154 selectin P precursor [Homo sapiens]                      192   3e-48
gi|168693643 decay accelerating factor for complement isoform 2 ...   168   5e-41
gi|10835143 decay accelerating factor for complement isoform 1 p...   168   5e-41
gi|27502413 CD46 antigen, complement regulatory protein isoform ...   159   3e-38
gi|27502402 CD46 antigen, complement regulatory protein isoform ...   159   3e-38
gi|27502425 CD46 antigen, complement regulatory protein isoform ...   159   3e-38
gi|27502423 CD46 antigen, complement regulatory protein isoform ...   159   3e-38
gi|187960042 selectin E precursor [Homo sapiens]                      155   6e-37
gi|27502421 CD46 antigen, complement regulatory protein isoform ...   154   8e-37
gi|27502417 CD46 antigen, complement regulatory protein isoform ...   154   8e-37
gi|27502415 CD46 antigen, complement regulatory protein isoform ...   154   8e-37
gi|27502407 CD46 antigen, complement regulatory protein isoform ...   154   8e-37
gi|24432108 CD46 antigen, complement regulatory protein isoform ...   154   8e-37
gi|27502411 CD46 antigen, complement regulatory protein isoform ...   154   1e-36
gi|27502409 CD46 antigen, complement regulatory protein isoform ...   154   1e-36
gi|27502405 CD46 antigen, complement regulatory protein isoform ...   154   1e-36
gi|27502419 CD46 antigen, complement regulatory protein isoform ...   153   2e-36

>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score = 5364 bits (13914), Expect = 0.0
 Identities = 2489/2489 (100%), Positives = 2489/2489 (100%)

Query: 1    MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE 60
            MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE
Sbjct: 1    MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE 60

Query: 61   FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
            FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG
Sbjct: 61   FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120

Query: 121  IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180
            IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST
Sbjct: 121  IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180

Query: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
            NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
Sbjct: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240

Query: 241  PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 300
            PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
Sbjct: 241  PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 300

Query: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360
            PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD
Sbjct: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360

Query: 361  FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 420
            FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
Sbjct: 361  FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 420

Query: 421  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 480
            CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW
Sbjct: 421  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 480

Query: 481  SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 540
            SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL
Sbjct: 481  SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 540

Query: 541  VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 600
            VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN
Sbjct: 541  VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 600

Query: 601  AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE 660
            AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE
Sbjct: 601  AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE 660

Query: 661  PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 720
            PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF
Sbjct: 661  PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 720

Query: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780
            VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY
Sbjct: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780

Query: 781  DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840
            DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF
Sbjct: 781  DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840

Query: 841  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 900
            QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC
Sbjct: 841  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 900

Query: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960
            DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA
Sbjct: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960

Query: 961  SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020
            SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD
Sbjct: 961  SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020

Query: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 1080
            IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST
Sbjct: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 1080

Query: 1081 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 1140
            NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
Sbjct: 1081 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 1140

Query: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 1200
            PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
Sbjct: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 1200

Query: 1201 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 1260
            PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD
Sbjct: 1201 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 1260

Query: 1261 FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 1320
            FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
Sbjct: 1261 FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 1320

Query: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 1380
            CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW
Sbjct: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 1380

Query: 1381 SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 1440
            SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL
Sbjct: 1381 SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 1440

Query: 1441 VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 1500
            VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN
Sbjct: 1441 VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 1500

Query: 1501 TAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGE 1560
            TAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGE
Sbjct: 1501 TAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGE 1560

Query: 1561 PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 1620
            PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF
Sbjct: 1561 PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 1620

Query: 1621 VMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY 1680
            VMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY
Sbjct: 1621 VMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY 1680

Query: 1681 DLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGF 1740
            DLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGF
Sbjct: 1681 DLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGF 1740

Query: 1741 RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTC 1800
            RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTC
Sbjct: 1741 RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTC 1800

Query: 1801 DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIP 1860
            DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIP
Sbjct: 1801 DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIP 1860

Query: 1861 INDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHI 1920
            INDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHI
Sbjct: 1861 INDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHI 1920

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF
Sbjct: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
            YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK
Sbjct: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC
Sbjct: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100

Query: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS 2160
            QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS
Sbjct: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS 2160

Query: 2161 CDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCE 2220
            CDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCE
Sbjct: 2161 CDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCE 2220

Query: 2221 QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN 2280
            QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN
Sbjct: 2221 QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN 2280

Query: 2281 GVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIF 2340
            GVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIF
Sbjct: 2281 GVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIF 2340

Query: 2341 CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWS 2400
            CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWS
Sbjct: 2341 CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWS 2400

Query: 2401 QCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKE 2460
            QCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKE
Sbjct: 2401 QCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKE 2460

Query: 2461 VAIHLHSQGGSSVHPRTLQTNEENSRVLP 2489
            VAIHLHSQGGSSVHPRTLQTNEENSRVLP
Sbjct: 2461 VAIHLHSQGGSSVHPRTLQTNEENSRVLP 2489


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score = 4204 bits (10904), Expect = 0.0
 Identities = 1950/1999 (97%), Positives = 1962/1999 (98%)

Query: 491  GHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 550
            G C AP+   FA+    T+  +FPIGT L YECRP Y GRPFSI CL N VW+  KD C+
Sbjct: 41   GQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCR 100

Query: 551  RKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI 610
            RKSC+ PPDPVNGMVHVI  IQ GS+I YSCT G+RLIG SSA CI+SG+   W  + PI
Sbjct: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPI 160

Query: 611  CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
            C RIPCGLPPTI NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD
Sbjct: 161  CDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 220

Query: 671  QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 730
            QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC
Sbjct: 221  QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 280

Query: 731  QALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 790
            QALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC
Sbjct: 281  QALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 340

Query: 791  TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 850
            TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC
Sbjct: 341  TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 400

Query: 851  VLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 910
            VLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSF
Sbjct: 401  VLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 460

Query: 911  DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
            DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK
Sbjct: 461  DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 520

Query: 971  YECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS 1030
            YECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS
Sbjct: 521  YECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS 580

Query: 1031 CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSV 1090
            CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSV
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSV 640

Query: 1091 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 1150
            VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS
Sbjct: 641  VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 700

Query: 1151 DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQ 1210
            DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQ
Sbjct: 701  DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQ 760

Query: 1211 RDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRV 1270
            RDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRV
Sbjct: 761  RDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRV 820

Query: 1271 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG 1330
            LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG
Sbjct: 821  LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG 880

Query: 1331 RHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL 1390
            RHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL
Sbjct: 881  RHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL 940

Query: 1391 GHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 1450
            GHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK
Sbjct: 941  GHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 1000

Query: 1451 RKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPI 1510
            RKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPI
Sbjct: 1001 RKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPI 1060

Query: 1511 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1570
            CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1120

Query: 1571 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
            QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC
Sbjct: 1121 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180

Query: 1631 QALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1690
            QALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC
Sbjct: 1181 QALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1240

Query: 1691 TPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1750
            TPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC
Sbjct: 1241 TPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1300

Query: 1751 VLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF 1810
            VLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF
Sbjct: 1301 VLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF 1360

Query: 1811 NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGT 1870
            NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGT
Sbjct: 1361 NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGT 1420

Query: 1871 SLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTV 1930
            SLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTV
Sbjct: 1421 SLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTV 1480

Query: 1931 NYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHN 1990
            NYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHN
Sbjct: 1481 NYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHN 1540

Query: 1991 GTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAI 2050
            GTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAI
Sbjct: 1541 GTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAI 1600

Query: 2051 RVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGE 2110
            RVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGE
Sbjct: 1601 RVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGE 1660

Query: 2111 HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPH 2170
            HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPH
Sbjct: 1661 HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPH 1720

Query: 2171 GRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAI 2230
            GRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAI
Sbjct: 1721 GRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAI 1780

Query: 2231 LNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 2290
            LNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC
Sbjct: 1781 LNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 1840

Query: 2291 ELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQL 2350
            ELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQL
Sbjct: 1841 ELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQL 1900

Query: 2351 DHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 2410
            DHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP
Sbjct: 1901 DHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 1960

Query: 2411 PLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGG 2470
            PLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGG
Sbjct: 1961 PLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGG 2020

Query: 2471 SSVHPRTLQTNEENSRVLP 2489
            SSVHPRTLQTNEENSRVLP
Sbjct: 2021 SSVHPRTLQTNEENSRVLP 2039



 Score = 3655 bits (9479), Expect = 0.0
 Identities = 1708/1972 (86%), Positives = 1777/1972 (90%), Gaps = 15/1972 (0%)

Query: 1    MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE 60
            MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE
Sbjct: 1    MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE 60

Query: 61   FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
            FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG
Sbjct: 61   FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120

Query: 121  IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180
            IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST
Sbjct: 121  IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180

Query: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
            NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
Sbjct: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240

Query: 241  PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 300
            PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
Sbjct: 241  PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 300

Query: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360
            PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD
Sbjct: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360

Query: 361  FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 420
            FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
Sbjct: 361  FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 420

Query: 421  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 480
            CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW
Sbjct: 421  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 480

Query: 481  SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 540
            SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL
Sbjct: 481  SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 540

Query: 541  VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 600
            VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN
Sbjct: 541  VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 600

Query: 601  AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE 660
            AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE
Sbjct: 601  AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE 660

Query: 661  PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 720
            PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF
Sbjct: 661  PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 720

Query: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780
            VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY
Sbjct: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780

Query: 781  DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840
            DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF
Sbjct: 781  DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840

Query: 841  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 900
            QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK VNYTC
Sbjct: 841  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTC 900

Query: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960
            DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA
Sbjct: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960

Query: 961  SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020
            SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD
Sbjct: 961  SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020

Query: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 1080
            IQVGSRINYSCTTGHRLIGHSSAECILSGN AHWSTKPPICQRIPCGLPPTIANGDFIST
Sbjct: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST 1080

Query: 1081 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 1140
            NRENFHYGSVVTYRCN GS GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
Sbjct: 1081 NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 1140

Query: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 1200
            PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
Sbjct: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP 1200

Query: 1201 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 1260
            P++LH E T   +DNFSPGQEVFYSCEPGYDLRGAAS+ CTPQGDWSP AP C VKSCDD
Sbjct: 1201 PEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD 1260

Query: 1261 FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 1320
            F+GQL +GRVLFP+NLQLGAKV FVCDEGF+LKGSS S+CVL GM SLWN+SVPVCE IF
Sbjct: 1261 FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIF 1320

Query: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 1380
            CP+PP I NGRHTG P    P+GK ++YTCDPHPDRG +F+LIGESTIRCTSDP GNGVW
Sbjct: 1321 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVW 1380

Query: 1381 SSPAPRCGI---LGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCL 1437
            SSPAPRC +    GHC+ P+ F FA      N  +FP+GTSL YECRP Y+G+ FSI+CL
Sbjct: 1381 SSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCL 1440

Query: 1438 DNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL 1497
            +NLVWSS +D C+RKSC  PP+P NGMVH+ TD Q GS +NYSC  G RLIG  S  C++
Sbjct: 1441 ENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV 1500

Query: 1498 SGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFEL 1557
            SGN   W  K PIC+ I C  PPTI+NGDF S NR +FH G+VVTY+C+ G  G ++FEL
Sbjct: 1501 SGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFEL 1560

Query: 1558 VGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQ 1617
            VGE SIYCTS DDQVG+WS P P+CI  NKCT P VEN I V  NRS F+L E++ FRCQ
Sbjct: 1561 VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQ 1620

Query: 1618 PGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCE 1677
            PGFVM G   V+CQ   +W P+LP CSRVCQPPPEILHGEHT SHQDNFSPGQEVFYSCE
Sbjct: 1621 PGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCE 1680

Query: 1678 PGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCD 1737
            P YDLRGAASLHCTPQGDWSPEAPRC VKSCDDFLGQLPHGRVL PLNLQLGAKVSFVCD
Sbjct: 1681 PSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCD 1740

Query: 1738 EGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEIS 1797
            EGFRLKG S SHCVL GM++LWN+SVPVCE IFCPNPPAILNGRHTGTP GDIPYGKEIS
Sbjct: 1741 EGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEIS 1800

Query: 1798 YTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASP 1857
            Y CD HPDRGMTFNLIGES+IRCTSDP GNGVWSSPAPRCELSV A  C  P +      
Sbjct: 1801 YACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAA-CPHPPKIQNGHY 1859

Query: 1858 TIPINDFEFPVGTSLNYECRPGYF--GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFN 1915
                     P G +++Y C PGY   GK F I C +  +WS ++  C+  +C  P    N
Sbjct: 1860 IGGHVSLYLP-GMTISYICDPGYLLVGKGF-IFCTDQGIWSQLDHYCKEVNCSFPLF-MN 1916

Query: 1916 GM---VHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1964
            G+   + +     +G  V   C +G+ L GSP + C        WD     C
Sbjct: 1917 GISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR---WDPPLAKC 1965



 Score =  701 bits (1809), Expect = 0.0
 Identities = 331/571 (57%), Positives = 400/571 (70%), Gaps = 18/571 (3%)

Query: 1839 LSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSV 1898
            L V  G C  PE  PFA PT   ++FEFP+GT LNYECRPGY G+ FSI CL+N VW+  
Sbjct: 36   LPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGA 95

Query: 1899 EDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD 1958
            +D CRRKSC  PP+P NGMVH+    QFGS + YSC +G+RLIGS S TC++SG+ V WD
Sbjct: 96   KDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD 155

Query: 1959 KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYC 2018
             + PIC+ I C  PPTI+NGDF S NR +FH G+VVTY+C+ G  G ++FELVGE SIYC
Sbjct: 156  NETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYC 215

Query: 2019 TSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS 2078
            TS DDQVG+WS P P+CI  NKCT P VEN I V  NRS F+L E++ FRCQPGFVM G 
Sbjct: 216  TSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275

Query: 2079 HTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 2138
              V+CQ   +W P+LP CSRVCQPPP++LH E T   +DNFSPGQEVFYSCEP YDLRGA
Sbjct: 276  RRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335

Query: 2139 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGR 2198
            AS+ CTPQGDWSP AP C VKSCDDF+GQL +GRVL P+NLQLGAKV FVCDEGF+LKG 
Sbjct: 336  ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGS 395

Query: 2199 SASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPD 2258
            SAS+CVLAGM++LWNSSVPVCEQIFCP+PP I NGRHTG P    P+GK ++Y CD HPD
Sbjct: 396  SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455

Query: 2259 RGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGG------ 2312
            RG +F+LIGES+IRCTSDPQGNGVWSSPAPRC   +   C  P      H++        
Sbjct: 456  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC--GILGHCQAP-----DHFLFAKLKTQT 508

Query: 2313 HVSLYLPGMTISYICDPGYLLVGKGF-IFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKE 2371
            + S +  G ++ Y C P Y   G+ F I C D  +WS     CK  +C  P   + ++  
Sbjct: 509  NASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTP--PDPVNGM 564

Query: 2372 LEMKKVYHYGDYVTLKCEDGYTLEGSPWSQC 2402
            + +      G  +   C  G+ L G   ++C
Sbjct: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAEC 595



 Score =  166 bits (419), Expect = 3e-40
 Identities = 99/343 (28%), Positives = 157/343 (45%), Gaps = 7/343 (2%)

Query: 36   LPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTG 94
            LP     C  P  +     T L+ +  F  G  + Y C P Y  R   S+ C     W+ 
Sbjct: 1643 LPHCSRVCQPPPEILHGEHT-LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 1701

Query: 95   AKDRCRRKSCRNPPDPV-NGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVI 153
               RC  KSC +    + +G V +   +Q G+++ + C +G+RL G S++ C+++G   +
Sbjct: 1702 EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKAL 1761

Query: 154  WDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 213
            W++  P+C++I C  PP I NG    T   +  YG  ++Y C+        F L+GE SI
Sbjct: 1762 WNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSI 1821

Query: 214  YCTSNDDQVGIWSGPAPQC--IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGF 270
             CTS+    G+WS PAP+C   +P  C  PP ++NG  +  + SL+     + + C PG+
Sbjct: 1822 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 1881

Query: 271  VMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG 329
            ++ G   + C     W      C  V C  P  +    +    K  +  G  V   CE G
Sbjct: 1882 LLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDG 1941

Query: 330  YDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF 372
            Y L G+   +C     W P    C  ++ D  +   L+G + F
Sbjct: 1942 YTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFF 1984


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score =  778 bits (2009), Expect = 0.0
 Identities = 391/539 (72%), Positives = 417/539 (77%), Gaps = 27/539 (5%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSI 84
           G LLA +VLL    +  QCN PEWLPFARPTNLTD+FEFPIGTYLNYECRPGYSGRPFSI
Sbjct: 18  GLLLAALVLLLSSFS-DQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI 76

Query: 85  ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSAT 144
           ICLKNSVWT AKD+C+RKSCRNPPDPVNGM HVIK IQF SQIKYSC KGYRLIGSSSAT
Sbjct: 77  ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSAT 136

Query: 145 CIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV 204
           CIISG+TVIWDN+TP+CDRI CGLPPTI NGDF S +RE FHYGSVVTY CN GS G+KV
Sbjct: 137 CIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV 196

Query: 205 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
           FELVGEPSIYCTS DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF
Sbjct: 197 FELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 256

Query: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 324
           RCQPGF MKGP  VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY
Sbjct: 257 RCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316

Query: 325 SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384
           SCEPGYDLRG+  + CTPQGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDF
Sbjct: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDF 376

Query: 385 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFG 443
           VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE+  C +PPV  NG  H    + V   G
Sbjct: 377 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---G 433

Query: 444 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFA 502
             +NY+C       T   LIG S+  C     GN   WS   P C  +  C  P   L  
Sbjct: 434 SRINYSCT------TGHRLIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNG 484

Query: 503 KLKTQTNASDFPIGTSLKYECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 550
           +  T T   D P G  + Y C P    G  F++              N VWSSP   C+
Sbjct: 485 R-HTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  689 bits (1778), Expect = 0.0
 Identities = 349/521 (66%), Positives = 377/521 (72%), Gaps = 26/521 (4%)

Query: 493  CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 552
            C  P+   FA+    T+  +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94

Query: 553  SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
            SC+ PPDPVNGM HVI DIQ  S+I YSC  G+RLIG SSA CI+SGN   W  K P+C 
Sbjct: 95   SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154

Query: 613  RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
            RI CGLPPTIANGDF S +RE FHYGSVVTY CN GS G+KVFELVGEPSIYCTS DDQV
Sbjct: 155  RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214

Query: 673  GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 732
            GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP  VKCQA
Sbjct: 215  GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274

Query: 733  LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 792
            LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG+  + CTP
Sbjct: 275  LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334

Query: 793  QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL 852
            QGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDFVCDEGFQLKGSSASYCVL
Sbjct: 335  QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394

Query: 853  AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 911
            AGMESLWNSSVPVCE+  C +PPV  NG  H    + V   G  +NY+C       T   
Sbjct: 395  AGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---GSRINYSCT------TGHR 445

Query: 912  LIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
            LIG S+  C     GN   WS   P C  +  C  P   L  +  T T   D P G  + 
Sbjct: 446  LIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNGR-HTGTPLGDIPYGKEVS 501

Query: 971  YECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 1000
            Y C P    G  F++              N VWSSP   C+
Sbjct: 502  YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  689 bits (1778), Expect = 0.0
 Identities = 349/521 (66%), Positives = 377/521 (72%), Gaps = 26/521 (4%)

Query: 943  CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 1002
            C  P+   FA+    T+  +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94

Query: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
            SC+ PPDPVNGM HVI DIQ  S+I YSC  G+RLIG SSA CI+SGN   W  K P+C 
Sbjct: 95   SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154

Query: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 1122
            RI CGLPPTIANGDF S +RE FHYGSVVTY CN GS G+KVFELVGEPSIYCTS DDQV
Sbjct: 155  RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214

Query: 1123 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1182
            GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP  VKCQA
Sbjct: 215  GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274

Query: 1183 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 1242
            LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG+  + CTP
Sbjct: 275  LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334

Query: 1243 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL 1302
            QGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDFVCDEGFQLKGSSASYCVL
Sbjct: 335  QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394

Query: 1303 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 1361
            AGMESLWNSSVPVCE+  C +PPV  NG  H    + V   G  +NY+C       T   
Sbjct: 395  AGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---GSRINYSCT------TGHR 445

Query: 1362 LIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 1420
            LIG S+  C     GN   WS   P C  +  C  P   L  +  T T   D P G  + 
Sbjct: 446  LIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNGR-HTGTPLGDIPYGKEVS 501

Query: 1421 YECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 1450
            Y C P    G  F++              N VWSSP   C+
Sbjct: 502  YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  667 bits (1722), Expect = 0.0
 Identities = 338/524 (64%), Positives = 368/524 (70%), Gaps = 31/524 (5%)

Query: 1393 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 1452
            C  P+   FA+    T+  +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94

Query: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
            SC+ PPDPVNGM HVI DIQ  S+I YSC  G+RLIG SSA CI+SGNT  W  K P+C 
Sbjct: 95   SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
            RI CGLPPTIANGDF S +RE FHYGSVVTY CNLGSRG+KVFELVGEPSIYCTS DDQV
Sbjct: 155  RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214

Query: 1573 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1632
            GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP  VKCQA
Sbjct: 215  GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274

Query: 1633 LNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP 1692
            LNKWEPELPSCSRVCQPPP++LH E T   +DNFSPGQEVFYSCEPGYDLRG+  LHCTP
Sbjct: 275  LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334

Query: 1693 QGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL 1752
            QGDWSP APRC VKSCDDFLGQLP+G VLFPLNLQLGAKV FVCDEGF+LKGSS S+CVL
Sbjct: 335  QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394

Query: 1753 VGMRSLWNNSVPVCEHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFN 1811
             GM SLWN+SVPVCE   C  PP  +NG  H  T   DI  G  I+Y+C           
Sbjct: 395  AGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCT------TGHR 445

Query: 1812 LIGESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPT-IPINDFEFPVG 1869
            LIG S+  C     GN   WS   P C+       C  P        T  P+ D   P G
Sbjct: 446  LIGHSSAECILS--GNTAHWSMKPPICQQI----FCPNPPAILNGRHTGTPLGD--IPYG 497

Query: 1870 TSLNYECRP----GYFGKMFSISCLE-------NLVWSSVEDNC 1902
              ++Y C P    G    +   S +        N VWSS    C
Sbjct: 498  KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541



 Score =  612 bits (1577), Expect = e-174
 Identities = 302/529 (57%), Positives = 358/529 (67%), Gaps = 26/529 (4%)

Query: 1839 LSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSV 1898
            LS  +  C  PE  PFA PT   +DFEFP+GT LNYECRPGY G+ FSI CL+N VW+S 
Sbjct: 28   LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSA 87

Query: 1899 EDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD 1958
            +D C+RKSC  PP+P NGM H+  D QF S + YSC +G+RLIGS S TC++SGN V WD
Sbjct: 88   KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147

Query: 1959 KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYC 2018
             K P+C+ I C  PPTI+NGDF S +R  FH G+VVTY C+ G  G+++FELVGE SIYC
Sbjct: 148  NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207

Query: 2019 TSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS 2078
            TSKDDQVG+WS P P+CI  NKCT P VEN I V  NRS F+L E++ FRCQPGF M G 
Sbjct: 208  TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267

Query: 2079 HTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 2138
              V+CQ   +W P+LP CSRVCQPPP++LH E T   +DNFSPGQEVFYSCEP YDLRG+
Sbjct: 268  SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327

Query: 2139 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGR 2198
              LHCTPQGDWSP APRC VKSCDDFLGQLP+G VL PLNLQLGAKV FVCDEGF+LKG 
Sbjct: 328  TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387

Query: 2199 SASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHP 2257
            SAS+CVLAGM++LWNSSVPVCE+  C  PP  +NG  H  T   DI  G  I+Y+C T  
Sbjct: 388  SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCTT-- 442

Query: 2258 DRGMTFNLIGESSIRCTSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL 2316
                   LIG SS  C     GN   WS   P C+      CP+PP I NG + G  +  
Sbjct: 443  ----GHRLIGHSSAECIL--SGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGD 493

Query: 2317 YLPGMTISYICDP------GYLLVGKGFIFCTDQ----GIWSQLDHYCK 2355
               G  +SY CDP       + L+G+  I  T +    G+WS     C+
Sbjct: 494  IPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  288 bits (736), Expect = 6e-77
 Identities = 197/556 (35%), Positives = 268/556 (48%), Gaps = 82/556 (14%)

Query: 164 IPCGLP---PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 220
           +P  LP   PT    DF       F  G+ + Y C PG  GR         SI C  N  
Sbjct: 37  VPEWLPFARPTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS- 82

Query: 221 QVGIWSGPAPQCIIPNKCTPPNVENGI--LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
              +W+    +C   +   PP+  NG+  ++ D          +++ C  G+ + G    
Sbjct: 83  ---VWTSAKDKCKRKSCRNPPDPVNGMAHVIKD----IQFRSQIKYSCPKGYRLIGSSSA 135

Query: 279 KCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG----- 329
            C        W+ + P C R+ C  PP + + + T   ++ F  G  V Y C  G     
Sbjct: 136 TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKK 195

Query: 330 -YDLRGAASMRCTPQGD----WSPAAPTCEVKS-CDDFMGQ----LLNGRVLFPVNLQLG 379
            ++L G  S+ CT + D    WS  AP C + + C     +    + + R LF +N    
Sbjct: 196 VFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN---- 251

Query: 380 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 439
             V+F C  GF +KG S   C        W   +P C ++ C  PP + +   T +  + 
Sbjct: 252 EVVEFRCQPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDN 307

Query: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI------LGHC 493
           F  G+ V Y+C+P       +DL G + + CT  PQG+  WS  APRC +      LG  
Sbjct: 308 FSPGQEVFYSCEP------GYDLRGSTYLHCT--PQGD--WSPAAPRCEVKSCDDFLG-- 355

Query: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNL--VWSSPKDVC 549
           Q P+  +   L  Q       +G  + + C   +   G   S   L  +  +W+S   VC
Sbjct: 356 QLPNGHVLFPLNLQ-------LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408

Query: 550 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
           +RKSC+TPP PVNGMVHVITDI VGSRINYSCTTGHRLIGHSSAECILSGN AHWS KPP
Sbjct: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468

Query: 610 ICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSND 669
           ICQ+I C  PP I NG    T   +  YG  V+Y C+P       F L+GE +I  TS  
Sbjct: 469 ICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEP 528

Query: 670 DQVGIWSGPAPQCIIP 685
              G+WS PAP+C +P
Sbjct: 529 HGNGVWSSPAPRCELP 544



 Score =  288 bits (736), Expect = 6e-77
 Identities = 197/556 (35%), Positives = 268/556 (48%), Gaps = 82/556 (14%)

Query: 614  IPCGLP---PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
            +P  LP   PT    DF       F  G+ + Y C PG  GR         SI C  N  
Sbjct: 37   VPEWLPFARPTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS- 82

Query: 671  QVGIWSGPAPQCIIPNKCTPPNVENGI--LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 728
               +W+    +C   +   PP+  NG+  ++ D          +++ C  G+ + G    
Sbjct: 83   ---VWTSAKDKCKRKSCRNPPDPVNGMAHVIKD----IQFRSQIKYSCPKGYRLIGSSSA 135

Query: 729  KCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG----- 779
             C        W+ + P C R+ C  PP + + + T   ++ F  G  V Y C  G     
Sbjct: 136  TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKK 195

Query: 780  -YDLRGAASMRCTPQGD----WSPAAPTCEVKS-CDDFMGQ----LLNGRVLFPVNLQLG 829
             ++L G  S+ CT + D    WS  AP C + + C     +    + + R LF +N    
Sbjct: 196  VFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN---- 251

Query: 830  AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 889
              V+F C  GF +KG S   C        W   +P C ++ C  PP + +   T +  + 
Sbjct: 252  EVVEFRCQPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDN 307

Query: 890  FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI------LGHC 943
            F  G+ V Y+C+P       +DL G + + CT  PQG+  WS  APRC +      LG  
Sbjct: 308  FSPGQEVFYSCEP------GYDLRGSTYLHCT--PQGD--WSPAAPRCEVKSCDDFLG-- 355

Query: 944  QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNL--VWSSPKDVC 999
            Q P+  +   L  Q       +G  + + C   +   G   S   L  +  +W+S   VC
Sbjct: 356  QLPNGHVLFPLNLQ-------LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408

Query: 1000 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
            +RKSC+TPP PVNGMVHVITDI VGSRINYSCTTGHRLIGHSSAECILSGN AHWS KPP
Sbjct: 409  ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468

Query: 1060 ICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSND 1119
            ICQ+I C  PP I NG    T   +  YG  V+Y C+P       F L+GE +I  TS  
Sbjct: 469  ICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEP 528

Query: 1120 DQVGIWSGPAPQCIIP 1135
               G+WS PAP+C +P
Sbjct: 529  HGNGVWSSPAPRCELP 544



 Score =  200 bits (508), Expect = 2e-50
 Identities = 149/537 (27%), Positives = 238/537 (44%), Gaps = 42/537 (7%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKD-NFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
            L S S  C  P  +  A  T    D  F  G  + Y C PGY  R   S+ C     W+ 
Sbjct: 28   LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTS 86

Query: 799  AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
            A   C+ KSC +     +NG      ++Q  +++ + C +G++L GSS++ C+++G   +
Sbjct: 87   AKDKCKRKSCRN-PPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI 145

Query: 859  WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
            W++  PVC++I C  PP I NG  T    E F +G  V Y C+        F+L+GE +I
Sbjct: 146  WDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205

Query: 919  RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY 978
             CTS     G+WS PAP+C I   C  P+  +   +    N S F +   +++ C+P + 
Sbjct: 206  YCTSKDDQVGIWSGPAPQCIIPNKCTPPN--VENGILVSDNRSLFSLNEVVEFRCQPGFG 263

Query: 979  GR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG--MVHVITDIQVGSRINYSCTTGH 1035
             + P  + C     W      C R  C+ PPD ++         +   G  + YSC  G+
Sbjct: 264  MKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322

Query: 1036 RLIGHSSAECILSGNAAHWSTKPPICQRIPCG-LPPTIANGDFISTNRENFHYGSVVTYR 1094
             L G +   C   G+   WS   P C+   C      + NG  +     N   G+ V + 
Sbjct: 323  DLRGSTYLHCTPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPL--NLQLGAKVDFV 377

Query: 1095 CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGIL--VSDN 1152
            C+ G      F+L G  + YC     +  +W+   P C   +  TPP   NG++  ++D 
Sbjct: 378  CDEG------FQLKGSSASYCVLAGME-SLWNSSVPVCERKSCETPPVPVNGMVHVITD- 429

Query: 1153 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK---WEPELPSCSRV-CQPPPDVLHAER 1208
                 +   + + C  G  + G    +C        W  + P C ++ C  PP +L+   
Sbjct: 430  ---IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRH 486

Query: 1209 TQRDKDNFSPGQEVFYSCEPG------YDLRGAASMRCTPQ----GDWSPAAPTCEV 1255
            T     +   G+EV Y+C+P       ++L G +++R T +    G WS  AP CE+
Sbjct: 487  TGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543



 Score =  160 bits (404), Expect = 2e-38
 Identities = 93/324 (28%), Positives = 147/324 (45%), Gaps = 6/324 (1%)

Query: 2113 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGR 2172
            L+    F  G  + Y C P Y  R   S+ C     W+    +C  KSC +    + +G 
Sbjct: 49   LTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTSAKDKCKRKSCRNPPDPV-NGM 106

Query: 2173 VLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 2232
              +  ++Q  +++ + C +G+RL G S++ C+++G   +W++  PVC++I C  PP I N
Sbjct: 107  AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN 166

Query: 2233 GRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCEL 2292
            G  T        YG  ++Y C+        F L+GE SI CTS     G+WS PAP+C  
Sbjct: 167  GDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-- 224

Query: 2293 SVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDH 2352
             +P  C  PP ++NG  +  + SL+     + + C PG+ + G   + C     W     
Sbjct: 225  IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELP 283

Query: 2353 YCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
             C  V C  P  +    +    K  +  G  V   CE GY L GS +  C     W P  
Sbjct: 284  SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAA 342

Query: 2413 AKCTSRTHDALIVGTLSGTIFFIL 2436
             +C  ++ D  +    +G + F L
Sbjct: 343  PRCEVKSCDDFLGQLPNGHVLFPL 366



 Score =  154 bits (390), Expect = 8e-37
 Identities = 76/175 (43%), Positives = 100/175 (57%), Gaps = 4/175 (2%)

Query: 65  IGTYLNYECRPGY----SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
           +G  +++ C  G+    S   + ++    S+W  +   C RKSC  PP PVNGMVHVI  
Sbjct: 370 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD 429

Query: 121 IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180
           I  GS+I YSCT G+RLIG SSA CI+SG+T  W  + PIC +I C  PP I NG    T
Sbjct: 430 IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGT 489

Query: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235
              +  YG  V+Y C+P       F L+GE +I  TS     G+WS PAP+C +P
Sbjct: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELP 544



 Score =  137 bits (344), Expect = 2e-31
 Identities = 123/457 (26%), Positives = 196/457 (42%), Gaps = 75/457 (16%)

Query: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032
            PT    DF       F  GT + Y+C  G  G          SI C        VW+S  
Sbjct: 46   PTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS----VWTSAK 88

Query: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEI-----IRFRCQPGFVMVGSHTVQCQTNG 2087
             +C   +    P+       P N     + +I     I++ C  G+ ++GS +  C  +G
Sbjct: 89   DKCKRKSCRNPPD-------PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG 141

Query: 2088 R---WGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSC------EPSYDLRG 2137
                W  K P C R+ C  PP I +G+ T   ++ F  G  V Y C      +  ++L G
Sbjct: 142  NTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVG 201

Query: 2138 AASLHCTPQGD----WSPEAPRCTVKS-CDDFLGQLPHGRVLLPLN---LQLGAKVSFVC 2189
              S++CT + D    WS  AP+C + + C      + +G +L+  N     L   V F C
Sbjct: 202  EPSIYCTSKDDQVGIWSGPAPQCIIPNKCTP--PNVENG-ILVSDNRSLFSLNEVVEFRC 258

Query: 2190 DEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEI 2249
              GF +KG S   C        W   +P C ++ C  PP +L+   T     +   G+E+
Sbjct: 259  QPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEV 314

Query: 2250 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHY 2309
             Y+C+        ++L G + + CT  PQG+  WS  APRCE  V +      ++ NGH 
Sbjct: 315  FYSCEPG------YDLRGSTYLHCT--PQGD--WSPAAPRCE--VKSCDDFLGQLPNGHV 362

Query: 2310 IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG---IWSQLDHYCKEVNCSFP-LFM 2365
            +   ++L L G  + ++CD G+ L G    +C   G   +W+     C+  +C  P + +
Sbjct: 363  LFP-LNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV 420

Query: 2366 NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQC 2402
            NG+   + +    H G  +   C  G+ L G   ++C
Sbjct: 421  NGM---VHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  689 bits (1779), Expect = 0.0
 Identities = 547/2005 (27%), Positives = 807/2005 (40%), Gaps = 334/2005 (16%)

Query: 570  DIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIS 629
            D++ GS++N  C  G +L+G+    C+   N   W+   P C+RI CG+PP + NG    
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCL---NQGQWTQPLPHCERISCGVPPPLENGFH-- 1701

Query: 630  TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 689
             + ++F+ GS VTY+CN G      + L+G+  ++CT N    G W+G +P C+  ++C 
Sbjct: 1702 -SADDFYAGSTVTYQCNNG------YYLLGDSRMFCTDN----GSWNGVSPSCLDVDECA 1750

Query: 690  -----------------------------------------PPNVENGILVSDNRSLFSL 708
                                                     P N ENG     +  ++++
Sbjct: 1751 VGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG---HSSGEIYTV 1807

Query: 709  NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSP 768
               V F CQ G+ + G  ++ C    +W   +P C  V    P +   E    ++  F+ 
Sbjct: 1808 GAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAI--PENGCIEELAFTF 1865

Query: 769  GQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQL 828
            G +V Y C  GY L G     C     WS + P CE   C      + NG+ +    L  
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS-PENINNGKYILS-GLTY 1923

Query: 829  GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLE 888
             +   + CD G+ L+G S   C  +G   +W+ + P C  +FC  PP I +   TG    
Sbjct: 1924 LSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIKDAVITGNN-- 1978

Query: 889  VFPFGKTVNYTCDP-------------------------------------HPDRGTSFD 911
             F F  TV YTC                                       H    T+  
Sbjct: 1979 -FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR 2037

Query: 912  LIGESTIRCTSDP-----------QGNGVWSSPA----PRCGILGHCQAPDHFLFAKLKT 956
            L G+      SD               G W  P     PRC I   C+ P    ++ L++
Sbjct: 2038 LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC-IAHFCEKPPSVSYSILES 2096

Query: 957  QTNASDFPIGTSLKYECRPEYY-GRPFSITCLDNLVWS-SPKDV-CKRKSCKTPPDPVNG 1013
             + A  F  G+ + ++C   +       I C+    W+ SP  + C    C  PP  +NG
Sbjct: 2097 VSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG 2155

Query: 1014 MVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIA 1073
                 ++   G+ + YSC  G  + G   + C  +G    WS+  P C  + CG PP + 
Sbjct: 2156 YASG-SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSPIPTCHPVSCGEPPKVE 2211

Query: 1074 NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
            NG    T    F   S V Y+CNPG      ++ VG P   C +N      W   +P   
Sbjct: 2212 NGFLEHTTGRIFE--SEVRYQCNPG------YKSVGSPVFVCQANRH----WHSESPLMC 2259

Query: 1134 IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL-P 1191
            +P  C  PP ++NG +  +N   F +   V+F C  G+ + G     CQ   KW  +  P
Sbjct: 2260 VPLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNP 2316

Query: 1192 SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAP 1251
             C     P P +L  +     K+  +    V +SC+ G+ L+G + ++C P   W+ + P
Sbjct: 2317 KCMPAKCPEPPLLENQLVL--KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFP 2374

Query: 1252 TCEVKSCDDFMGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 1310
             C++  C      L++  V  P + L  G+ V + C  GF L+G+S + C   G    W+
Sbjct: 2375 VCKIVLCTP--PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGT---WS 2429

Query: 1311 SSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRC 1370
            S +P C  + CP P  IPNG    + L          YTC P       F+L+G +T  C
Sbjct: 2430 SPLPECVPVECPQPEEIPNGIIDVQGLAYL---STALYTCKP------GFELVGNTTTLC 2480

Query: 1371 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YG 1429
                  NG W    P C  +  C  P   L  K     + +D   G ++ Y C   +   
Sbjct: 2481 GE----NGHWLGGKPTCKAI-ECLKPKEILNGKF----SYTDLHYGQTVTYSCNRGFRLE 2531

Query: 1430 RPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIG 1489
             P ++TCL+   W      C    C +P    NG V    D   G+ I YSC  G ++ G
Sbjct: 2532 GPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEG-ADYSYGAIIIYSCFPGFQVAG 2590

Query: 1490 HSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI--------------------- 1528
            H+   C  SG    WS+  P C  I CGLPP I  GD                       
Sbjct: 2591 HAMQTCEESG----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYV 2646

Query: 1529 ----------------------STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCT 1566
                                  +T+  NF YG++V+Y CN G      +EL+G P + C 
Sbjct: 2647 TPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG------YELLGNPVLICQ 2700

Query: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626
             +    G W+G AP CI      P   ENG L     S+ S    V++ C+PG ++ G  
Sbjct: 2701 ED----GTWNGSAPSCISIECDLPTAPENGFLRFTETSMGS---AVQYSCKPGHILAGSD 2753

Query: 1627 RVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
               C    KW    P C  + C+ P  +++G    S   N++    ++Y C+PGY L G 
Sbjct: 2754 LRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS---NYTYLSTLYYECDPGYVLNGT 2810

Query: 1686 ASLHCTPQGDWSPEAPRCAVKSCDD----FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFR 1741
                C    +W  + P C    C        GQ+      F        ++ + C+EGF 
Sbjct: 2811 ERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ------KEIEYTCNEGFL 2864

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCD 1801
            L+G+    C+  G    W+ + P C  + C  PP + NG   G   G   + KE+++ C 
Sbjct: 2865 LEGARSRVCLANGS---WSGATPDCVPVRCATPPQLANGVTEGLDYG---FMKEVTFHCH 2918

Query: 1802 PHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPI 1861
                    + L G   + C SD    G W +  P C    +  +C  PE      P    
Sbjct: 2919 EG------YILHGAPKLTCQSD----GNWDAEIPLC----KPVNCGPPEDLAHGFP---- 2960

Query: 1862 NDFEFPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFNGMV 1918
            N F F  G  + Y+C PGY  K+   S   CL N  WS    +C    C  P   + G V
Sbjct: 2961 NGFSFIHGGHIQYQCFPGY--KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEY-GTV 3017

Query: 1919 HINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNG 1978
            +  TD   G      C +GF+L+G    TC   G    W    P CE  SC   P I N 
Sbjct: 3018 N-GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGFPHCEHTSCGSLPMIPNA 3073

Query: 1979 DFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIST 2038
                 + TS     V+TY C +G      + + G   + CT K    GVWS P P C   
Sbjct: 3074 FI---SETSSWKENVITYSCRSG------YVIQGSSDLICTEK----GVWSQPYPVCEPL 3120

Query: 2039 NKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM-VGSHTVQCQTNGRWGPKLPHCS 2097
            +  + P V NA+         T    ++ RC  G+ M   + T  CQ +GRW P+   CS
Sbjct: 3121 SCGSPPSVANAV---ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCS 3177

Query: 2098 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP--EAPR 2155
                P PE +   H L H D+FS  ++V  SC   Y   G     C   G W P      
Sbjct: 3178 PKKCPLPENI--THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDES 3235

Query: 2156 CTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSS 2215
            C+  SC     + P    ++       + + + C+ G+ L+G     C        W+  
Sbjct: 3236 CSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQ---ENRQWSGG 3290

Query: 2216 VPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTS 2275
            V +C++  C  P   LNG+       +   G  + Y+C+    RG  ++L G S   CT 
Sbjct: 3291 VAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSCN----RG--YSLEGPSEAHCTE 3341

Query: 2276 DPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVG 2335
                NG WS P P C+   P  CP P  I     +      +     +S  C  G+LL G
Sbjct: 3342 ----NGTWSHPVPLCK---PNPCPVPFVIPENALLSEKE--FYVDQNVSIKCREGFLLQG 3392

Query: 2336 KGFIFCTDQGIWSQLDHYCKEVNCSFPLFM-NGISKELEMKKVYHYGDYVTLKCEDGYTL 2394
             G I C     W+Q    C++++C  P  + N I++ +     Y YGD +T  C  GY L
Sbjct: 3393 HGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH----YQYGDMITYSCYSGYML 3448

Query: 2395 EGSPWSQCQADDRW-DPPLAKCTSR 2418
            EG   S C  +  W  PP+ +   R
Sbjct: 3449 EGFLRSVCLENGTWTSPPICRAVCR 3473



 Score =  650 bits (1676), Expect = 0.0
 Identities = 546/2014 (27%), Positives = 800/2014 (39%), Gaps = 305/2014 (15%)

Query: 66   GTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF 123
            G+ +N  C PG+   G P    CL    WT     C R SC  PP   NG  H       
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF-HSADDFYA 1708

Query: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC---DRIPCG------------- 167
            GS + Y C  GY L+G S   C  +G    W+  +P C   D    G             
Sbjct: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVGSDCSEHASCLNVD 1765

Query: 168  -------LPPTITNGDFIST--------NRENFH-------YGSVVTYRCNPGSGGRKVF 205
                   +PP   +G   +         N EN H        G+ VT+ C  G      +
Sbjct: 1766 GSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEG------Y 1819

Query: 206  ELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 265
            +L+G   I C  +    G W+   P C   +   P   ENG +       F+    V +R
Sbjct: 1820 QLMGVTKITCLES----GEWNHLIPYCKAVSCGKPAIPENGCI---EELAFTFGSKVTYR 1872

Query: 266  CQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFY 324
            C  G+ + G +   C A + W    P C  V C  P ++ + +         S      Y
Sbjct: 1873 CNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTAS---Y 1929

Query: 325  SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384
            SC+ GY L+G + + CT  G W  A P C +  C +     +   V+   N      V +
Sbjct: 1930 SCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE--PPAIKDAVITGNNFTFRNTVTY 1987

Query: 385  VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 444
             C EG+ L G     C+  G    W+ S   C  + C  PP++    H         FG 
Sbjct: 1988 TCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVD---HASPETAHRLFGD 2041

Query: 445  TVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSP----APRCGILGHCQAPDHFL 500
               Y C         + L   S + C +     G W  P     PRC I   C+ P    
Sbjct: 2042 IAFYYC------SDGYSLADNSQLLCNA----QGKWVPPEGQDMPRC-IAHFCEKPPSVS 2090

Query: 501  FAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWS-SPKDV-CKRKSCKTP 557
            ++ L++ + A  F  G+ + ++C   +       I C+    W+ SP  + C    C  P
Sbjct: 2091 YSILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEP 2149

Query: 558  PDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG 617
            P  +NG     ++   G+ + YSC  G  + G   + C  +G    WS+  P C  + CG
Sbjct: 2150 PSIMNGYASG-SNYSFGAMVAYSCNKGFYIKGEKKSTCEATG---QWSSPIPTCHPVSCG 2205

Query: 618  LPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 677
             PP + NG    T    F   S V Y+CNPG      ++ VG P   C +N      W  
Sbjct: 2206 EPPKVENGFLEHTTGRIFE--SEVRYQCNPG------YKSVGSPVFVCQANRH----WHS 2253

Query: 678  PAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 736
             +P   +P  C  PP ++NG +  +N   F +   V+F C  G+ + G     CQ   KW
Sbjct: 2254 ESPLMCVPLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKW 2310

Query: 737  EPEL-PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795
              +  P C     P P +L  +     K+  +    V +SC+ G+ L+G + ++C P   
Sbjct: 2311 NKKSNPKCMPAKCPEPPLLENQLVL--KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ 2368

Query: 796  WSPAAPTCEVKSCDDFMGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLAG 854
            W+ + P C++  C      L++  V  P + L  G+ V + C  GF L+G+S + C   G
Sbjct: 2369 WNDSFPVCKIVLCTP--PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG 2426

Query: 855  MESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 914
                W+S +P C  + CP P  IPNG      ++   +  T  YTC P       F+L+G
Sbjct: 2427 ---TWSSPLPECVPVECPQPEEIPNGI---IDVQGLAYLSTALYTCKP------GFELVG 2474

Query: 915  ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECR 974
             +T  C      NG W    P C  +  C  P   L  K     + +D   G ++ Y C 
Sbjct: 2475 NTTTLCGE----NGHWLGGKPTCKAI-ECLKPKEILNGKF----SYTDLHYGQTVTYSCN 2525

Query: 975  PEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTT 1033
              +    P ++TCL+   W      C    C +P    NG V    D   G+ I YSC  
Sbjct: 2526 RGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEG-ADYSYGAIIIYSCFP 2584

Query: 1034 GHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFI--------------- 1078
            G ++ GH+   C  SG    WS+  P C  I CGLPP I  GD                 
Sbjct: 2585 GFQVAGHAMQTCEESG----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640

Query: 1079 ----------------------------STNRENFHYGSVVTYRCNPGSGGRKVFELVGE 1110
                                        +T+  NF YG++V+Y CNPG      +EL+G 
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG------YELLGN 2694

Query: 1111 PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 1170
            P + C  +    G W+G AP CI      P   ENG L     S+ S    V++ C+PG 
Sbjct: 2695 PVLICQED----GTWNGSAPSCISIECDLPTAPENGFLRFTETSMGS---AVQYSCKPGH 2747

Query: 1171 VMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG 1229
            ++ G     C    KW    P C  + C+ P  V++         N++    ++Y C+PG
Sbjct: 2748 ILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNG---SIKGSNYTYLSTLYYECDPG 2804

Query: 1230 YDLRGAASMRCTPQGDWSPAAPTCEVKSCD----DFMGQLLNGRVLFPVNLQLGAKVDFV 1285
            Y L G     C    +W    P C    C        GQ+      F        ++++ 
Sbjct: 2805 YVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ------KEIEYT 2858

Query: 1286 CDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKA 1345
            C+EGF L+G+ +  C+  G    W+ + P C  + C +PP + NG   G     + F K 
Sbjct: 2859 CNEGFLLEGARSRVCLANGS---WSGATPDCVPVRCATPPQLANGVTEGLD---YGFMKE 2912

Query: 1346 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 1405
            V + C         + L G   + C SD    G W +  P C  + +C  P+        
Sbjct: 2913 VTFHCH------EGYILHGAPKLTCQSD----GNWDAEIPLCKPV-NCGPPEDLAHG--- 2958

Query: 1406 TQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPP---DP 1460
               N   F  G  ++Y+C P Y  +G   S  CL N  WS     C    C TP      
Sbjct: 2959 -FPNGFSFIHGGHIQYQCFPGYKLHGNS-SRRCLSNGSWSGSSPSCLPCRCSTPVIEYGT 3016

Query: 1461 VNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPP 1520
            VNG     TD   G      C  G +L+G S   C   G    WS+  P C+   CG  P
Sbjct: 3017 VNG-----TDFDCGKAARIQCFKGFKLLGLSEITCEADG---QWSSGFPHCEHTSCGSLP 3068

Query: 1521 TIANGDFISTN--RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGP 1578
             I N     T+  +EN     V+TY C  G      + + G   + CT    + G+WS P
Sbjct: 3069 MIPNAFISETSSWKEN-----VITYSCRSG------YVIQGSSDLICT----EKGVWSQP 3113

Query: 1579 APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVM-KGPRRVKCQALNKWE 1637
             P C   +  +PP+V N +   +  +  S    V+ RC  G+ M        CQ   +W 
Sbjct: 3114 YPVCEPLSCGSPPSVANAVATGEAHTYES---EVKLRCLEGYTMDTDTDTFTCQKDGRWF 3170

Query: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697
            PE  SCS    P PE +   H   H D+FS  ++V  SC  GY   G     C   G W 
Sbjct: 3171 PERISCSPKKCPLPENI--THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE 3228

Query: 1698 P--EAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P      C+  SC     + P    +        + + + C+ G+ L+G+    C     
Sbjct: 3229 PPFSDESCSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC---QE 3283

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
               W+  V +C+   C  P   LNG+       +   G  + Y+C    +RG  ++L G 
Sbjct: 3284 NRQWSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSC----NRG--YSLEGP 3334

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASP-TIPINDFEFPVGTSLNY 1874
            S   CT     NG WS P P C+          P   PF  P    +++ EF V  +++ 
Sbjct: 3335 SEAHCTE----NGTWSHPVPLCK--------PNPCPVPFVIPENALLSEKEFYVDQNVSI 3382

Query: 1875 ECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYS 1933
            +CR G+  +    I+C  +  W+     C + SCGPP    N +       Q+G  + YS
Sbjct: 3383 KCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIAR-GVHYQYGDMITYS 3441

Query: 1934 CNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEII 1967
            C  G+ L G   + CL +G   TW    PIC  +
Sbjct: 3442 CYSGYMLEGFLRSVCLENG---TW-TSPPICRAV 3471



 Score =  627 bits (1617), Expect = e-179
 Identities = 569/2058 (27%), Positives = 803/2058 (39%), Gaps = 350/2058 (17%)

Query: 375  NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
            +L+ G+KV+  CD GFQL G+   YC+  G    W   +P CE+I C  PP + NG H+ 
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFHSA 1703

Query: 435  KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQ 494
               + F  G TV Y C+        + L+G+S + CT     NG W+  +P C  +  C 
Sbjct: 1704 ---DDFYAGSTVTYQCN------NGYYLLGDSRMFCTD----NGSWNGVSPSCLDVDECA 1750

Query: 495  APDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSC 554
                          +AS   +  S    C P Y G                K+  +   C
Sbjct: 1751 VGSD-------CSEHASCLNVDGSYICSCVPPYTG--------------DGKNCAEPIKC 1789

Query: 555  KTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 613
            K P +P NG  H   +I  VG+ + +SC  G++L+G +   C+ SG    W+   P C+ 
Sbjct: 1790 KAPGNPENG--HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE---WNHLIPYCKA 1844

Query: 614  IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
            + CG P    NG         F +GS VTYRCN G      + L G+    C +N     
Sbjct: 1845 VSCGKPAIPENG---CIEELAFTFGSKVTYRCNKG------YTLAGDKESSCLANSS--- 1892

Query: 674  IWSGPAPQCIIPNKCTPP-NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 732
             WS   P C  P KC+ P N+ NG  +    +  S      + C  G+ ++GP  ++C A
Sbjct: 1893 -WSHSPPVCE-PVKCSSPENINNGKYILSGLTYLS---TASYSCDTGYSLQGPSIIECTA 1947

Query: 733  LNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791
               W+   P+C  V C  PP +  A  T    +NF+    V Y+C+ GY L G  ++ C 
Sbjct: 1948 SGIWDRAPPACHLVFCGEPPAIKDAVITG---NNFTFRNTVTYTCKEGYTLAGLDTIECL 2004

Query: 792  PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCV 851
              G WS +   C   SCD+    +++       +   G    + C +G+ L  +S   C 
Sbjct: 2005 ADGKWSRSDQQCLAVSCDE--PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCN 2062

Query: 852  LAGMESLW----NSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 907
              G    W       +P C   FC  PP +            F  G  V++ C       
Sbjct: 2063 AQGK---WVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCME----- 2114

Query: 908  TSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGT 967
              F L   + I C    Q N    SP     I   C  P   +        + S++  G 
Sbjct: 2115 -GFVLNTSAKIECMRGGQWN---PSPMSIQCIPVRCGEPPSIM----NGYASGSNYSFGA 2166

Query: 968  SLKYECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGS 1025
             + Y C   +Y  G   S TC     WSSP   C   SC  PP   NG +   T     S
Sbjct: 2167 MVAYSCNKGFYIKGEKKS-TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFES 2225

Query: 1026 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI-CQRIPCGLPPTIANGDFISTNREN 1084
             + Y C  G++ +G     C  +    HW ++ P+ C  + CG PP I NG       EN
Sbjct: 2226 EVRYQCNPGYKSVGSPVFVCQAN---RHWHSESPLMCVPLDCGKPPPIQNGFM---KGEN 2279

Query: 1085 FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT-PPNV 1143
            F  GS V + CN G      +ELVG+ S  C  +    G W+  +    +P KC  PP +
Sbjct: 2280 FEVGSKVQFFCNEG------YELVGDSSWTCQKS----GKWNKKSNPKCMPAKCPEPPLL 2329

Query: 1144 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQP--- 1199
            EN +++ +   L +   VV F C+ G V++GP  +KC    +W    P C  V C P   
Sbjct: 2330 ENQLVLKE---LTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPL 2386

Query: 1200 -------PPDVLHAERT-------------------QRDKDNFSPGQE------------ 1221
                   P   LH   T                   Q D    SP  E            
Sbjct: 2387 ISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEI 2446

Query: 1222 ---------------VFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLL 1266
                             Y+C+PG++L G  +  C   G W    PTC+   C     ++L
Sbjct: 2447 PNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLK-PKEIL 2505

Query: 1267 NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPV 1326
            NG+  +  +L  G  V + C+ GF+L+G SA  C+  G    W+   P C  I C SP  
Sbjct: 2506 NGKFSY-TDLHYGQTVTYSCNRGFRLEGPSALTCLETGD---WDVDAPSCNAIHCDSPQP 2561

Query: 1327 IPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPR 1386
            I NG   G     + +G  + Y+C P       F + G +   C         WSS  P 
Sbjct: 2562 IENGFVEGAD---YSYGAIIIYSCFP------GFQVAGHAMQTCEESG-----WSSSIPT 2607

Query: 1387 CGILGHCQAPDHFLFA---KLKTQ------------------------------------ 1407
            C  +  C  P H  F    KLK                                      
Sbjct: 2608 CMPID-CGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKE 2666

Query: 1408 ---TNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462
               T++S+F  GT + Y C P Y   G P  I C ++  W+     C    C  P  P N
Sbjct: 2667 SPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTWNGSAPSCISIECDLPTAPEN 2725

Query: 1463 GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTI 1522
            G +   T+  +GS + YSC  GH L G     C+       WS   P C+ I C  P  +
Sbjct: 2726 GFLR-FTETSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCEAISCKKPNPV 2781

Query: 1523 ANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 1582
             NG   S    N+ Y S + Y C+ G      + L G     C  + +    W    P C
Sbjct: 2782 MNG---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTCQDDKN----WDEDEPIC 2828

Query: 1583 IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1642
            I  +  +PP   NG +  D    ++  + +E+ C  GF+++G R   C A   W    P 
Sbjct: 2829 IPVDCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885

Query: 1643 CSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP 1701
            C  V C  PP++ +G    +   ++   +EV + C  GY L GA  L C   G+W  E P
Sbjct: 2886 CVPVRCATPPQLANGV---TEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIP 2942

Query: 1702 RCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1758
             C   +C   +D     P+G      +   G  + + C  G++L G+S   C+  G    
Sbjct: 2943 LCKPVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS--- 2994

Query: 1759 WNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTI 1818
            W+ S P C    C + P I  G   GT   D   GK     C         F L+G S I
Sbjct: 2995 WSGSSPSCLPCRC-STPVIEYGTVNGT---DFDCGKAARIQCFKG------FKLLGLSEI 3044

Query: 1819 RCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRP 1878
             C +D    G WSS  P CE +        P  F        I++        + Y CR 
Sbjct: 3045 TCEAD----GQWSSGFPHCEHTSCGSLPMIPNAF--------ISETSSWKENVITYSCRS 3092

Query: 1879 GYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEG 1937
            GY  +  S + C E  VWS     C   SCG PP   N +      T + S V   C EG
Sbjct: 3093 GYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHT-YESEVKLRCLEG 3151

Query: 1938 FRLIGSPST-TCLVSGNNVTWDKKAPICEIISCEPPPTISN----GDFYSNNRTSFHNGT 1992
            + +     T TC   G    W  +   C    C  P  I++    GD +S NR       
Sbjct: 3152 YTMDTDTDTFTCQKDGR---WFPERISCSPKKCPLPENITHILVHGDDFSVNRQ------ 3202

Query: 1993 VVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP-PPRCISTNKCTAPEVENAIR 2051
             V+  C  G      +   G     C       G W  P      S   C  PE      
Sbjct: 3203 -VSVSCAEG------YTFEGVNISVCQLD----GTWEPPFSDESCSPVSCGKPESPEHGF 3251

Query: 2052 VPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGE 2110
            V G++  +T    I ++C+PG+ + G+    CQ N +W   +  C    C+ P E L+G+
Sbjct: 3252 VVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGK 3309

Query: 2111 HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCD-DFLGQLP 2169
              +   +N + G  V YSC   Y L G +  HCT  G WS   P C    C   F+  +P
Sbjct: 3310 ADI---ENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFV--IP 3364

Query: 2170 HGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPA 2229
               +L      +   VS  C EGF L+G     C        W  +   CE+I C  P  
Sbjct: 3365 ENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSAKCEKISCGPPAH 3421

Query: 2230 ILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPR 2289
            + N    G  +    YG  I+Y+C +       + L G     C      NG W+SP P 
Sbjct: 3422 VENAIARGVHY---QYGDMITYSCYS------GYMLEGFLRSVCLE----NGTWTSP-PI 3467

Query: 2290 CELSVPAACPHPPKIQNG 2307
            C     A C  P   QNG
Sbjct: 3468 CR----AVCRFP--CQNG 3479



 Score =  623 bits (1607), Expect = e-178
 Identities = 534/1995 (26%), Positives = 802/1995 (40%), Gaps = 335/1995 (16%)

Query: 314  DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 373
            ++  PG +V   C+PG+ L G     C  QG W+   P CE  SC   +   L       
Sbjct: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCG--VPPPLENGFHSA 1703

Query: 374  VNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC-------------EQIF 420
             +   G+ V + C+ G+ L G S  +C   G    WN   P C             E   
Sbjct: 1704 DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVGSDCSEHAS 1760

Query: 421  CPS----------PPVIPNGRHTGKPL---------------EVFPFGKTVNYTCDPHPD 455
            C +          PP   +G++  +P+               E++  G  V ++C     
Sbjct: 1761 CLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQ---- 1816

Query: 456  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKLKTQTNASDF 513
                + L+G + I C      +G W+   P C  +  G    P++    +L        F
Sbjct: 1817 --EGYQLMGVTKITCLE----SGEWNHLIPYCKAVSCGKPAIPENGCIEELA-------F 1863

Query: 514  PIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQ 572
              G+ + Y C   Y        +CL N  WS    VC+   C +P +  NG  ++++ + 
Sbjct: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YILSGLT 1922

Query: 573  VGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR 632
              S  +YSC TG+ L G S  EC  SG    W   PP C  + CG PP I   D + T  
Sbjct: 1923 YLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIK--DAVITG- 1976

Query: 633  ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 692
             NF + + VTY C  G      + L G  +I C ++    G WS    QC+  +   PP 
Sbjct: 1977 NNFTFRNTVTYTCKEG------YTLAGLDTIECLAD----GKWSRSDQQCLAVSCDEPPI 2026

Query: 693  VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP----ELPSC-SRVC 747
            V++    + +R LF   ++  + C  G+ +    ++ C A  KW P    ++P C +  C
Sbjct: 2027 VDHASPETAHR-LF--GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFC 2083

Query: 748  QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW--SPAAPTCEV 805
            + PP V ++      K  F+ G  V + C  G+ L  +A + C   G W  SP +  C  
Sbjct: 2084 EKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIP 2143

Query: 806  KSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 865
              C +    ++NG      N   GA V + C++GF +KG   S C   G    W+S +P 
Sbjct: 2144 VRCGE-PPSIMNG-YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSPIPT 2198

Query: 866  CEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923
            C  + C  PP + NG   HT   +    F   V Y C+P       +  +G     C   
Sbjct: 2199 CHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNP------GYKSVGSPVFVC--- 2245

Query: 924  PQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPF 982
             Q N  W S +P   +   C  P       +K      +F +G+ +++ C   Y      
Sbjct: 2246 -QANRHWHSESPLMCVPLDCGKPPPIQNGFMK----GENFEVGSKVQFFCNEGYELVGDS 2300

Query: 983  SITCLDNLVW---SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIG 1039
            S TC  +  W   S+PK  C    C  PP   N +V      +VG  + +SC  GH L G
Sbjct: 2301 SWTCQKSGKWNKKSNPK--CMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEGHVLQG 2357

Query: 1040 HSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGS 1099
             S  +C+ S     W+   P+C+ + C  PP I+ G  I ++    H+GS V Y C  G 
Sbjct: 2358 PSVLKCLPS---QQWNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYSCVGG- 2411

Query: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC-TPPNVENGILVSDNRSLFSL 1158
                 F L G  +  C  +    G WS P P+C +P +C  P  + NGI+  D + L  L
Sbjct: 2412 -----FFLRGNSTTLCQPD----GTWSSPLPEC-VPVECPQPEEIPNGII--DVQGLAYL 2459

Query: 1159 NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS 1217
            +  + + C+PGF + G     C     W    P+C  + C  P ++L+ + +  D     
Sbjct: 2460 STAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD---LH 2515

Query: 1218 PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQ 1277
             GQ V YSC  G+ L G +++ C   GDW   AP+C    CD    Q +    +   +  
Sbjct: 2516 YGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS--PQPIENGFVEGADYS 2573

Query: 1278 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG------- 1330
             GA + + C  GFQ+ G +   C     ES W+SS+P C  I C  PP I  G       
Sbjct: 2574 YGAIIIYSCFPGFQVAGHAMQTC----EESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKD 2629

Query: 1331 ----------------------RHTGKPLEV--------------FPFGKAVNYTCDPHP 1354
                                   H G   +               F +G  V+YTC+P  
Sbjct: 2630 DQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNP-- 2687

Query: 1355 DRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFP 1414
                 ++L+G   + C  D    G W+  AP C I   C  P     A        ++  
Sbjct: 2688 ----GYELLGNPVLICQED----GTWNGSAPSC-ISIECDLPT----APENGFLRFTETS 2734

Query: 1415 IGTSLKYECRPEYYGRPFSI-TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 1473
            +G++++Y C+P +      +  CL+N  WS     C+  SCK P   +NG +   ++   
Sbjct: 2735 MGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKG-SNYTY 2793

Query: 1474 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1533
             S + Y C  G+ L G     C    +  +W    PIC  + C  PP  ANG       +
Sbjct: 2794 LSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPVDCSSPPVSANG---QVRGD 2847

Query: 1534 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1593
             + +   + Y CN G      F L G  S  C +N    G WSG  P C+     TPP +
Sbjct: 2848 EYTFQKEIEYTCNEG------FLLEGARSRVCLAN----GSWSGATPDCVPVRCATPPQL 2897

Query: 1594 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPE 1652
             NG+    +   +   + V F C  G+++ G  ++ CQ+   W+ E+P C  V C PP +
Sbjct: 2898 ANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPED 2954

Query: 1653 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFL 1712
            + HG     +  +F  G  + Y C PGY L G +S  C   G WS  +P C    C   +
Sbjct: 2955 LAHGF---PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPV 3011

Query: 1713 GQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCP 1772
              + +G V    +   G      C +GF+L G S   C   G    W++  P CEH  C 
Sbjct: 3012 --IEYGTV-NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGFPHCEHTSCG 3065

Query: 1773 NPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSS 1832
            + P I N   + T S        I+Y+C         + + G S + CT      GVWS 
Sbjct: 3066 SLPMIPNAFISETSSWK---ENVITYSC------RSGYVIQGSSDLICTE----KGVWSQ 3112

Query: 1833 PAPRCE-----------LSVRAGHCKT-------------------------------PE 1850
            P P CE            +V  G   T                               PE
Sbjct: 3113 PYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPE 3172

Query: 1851 QFPFASPTIP---------INDFEFPVGTSLNYECRPGYFGKMFSIS-CLENLVWSS--V 1898
            +   +    P         ++  +F V   ++  C  GY  +  +IS C  +  W     
Sbjct: 3173 RISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFS 3232

Query: 1899 EDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD 1958
            +++C   SCG P  P +G V + +   F ST+ Y C  G+ L G+    C     N  W 
Sbjct: 3233 DESCSPVSCGKPESPEHGFV-VGSKYTFESTIIYQCEPGYELEGNRERVC---QENRQWS 3288

Query: 1959 KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYC 2018
                IC+   CE P    NG     NRT+   G  V Y C+ G      + L G    +C
Sbjct: 3289 GGVAICKETRCETPLEFLNGKADIENRTT---GPNVVYSCNRG------YSLEGPSEAHC 3339

Query: 2019 TSKDDQVGVWSSPPPRCISTNKCTAPEV--ENAIRVPGNRSFFTLTEIIRFRCQPGFVMV 2076
            T      G WS P P C   N C  P V  ENA+    +   F + + +  +C+ GF++ 
Sbjct: 3340 TEN----GTWSHPVPLC-KPNPCPVPFVIPENALL---SEKEFYVDQNVSIKCREGFLLQ 3391

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDL 2135
            G   + C  +  W      C ++ C PP    H E+ ++   ++  G  + YSC   Y L
Sbjct: 3392 GHGIITCNPDETWTQTSAKCEKISCGPP---AHVENAIARGVHYQYGDMITYSCYSGYML 3448

Query: 2136 RGAASLHCTPQGDWS 2150
             G     C   G W+
Sbjct: 3449 EGFLRSVCLENGTWT 3463



 Score =  584 bits (1505), Expect = e-166
 Identities = 485/1782 (27%), Positives = 736/1782 (41%), Gaps = 240/1782 (13%)

Query: 59   DEFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV 117
            +E  F  G+ + Y C  GY+        CL NS W+ +   C    C +P +  NG  ++
Sbjct: 1859 EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YI 1917

Query: 118  IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDF 177
            + G+ + S   YSC  GY L G S   C  SG   IWD   P C  + CG PP I   D 
Sbjct: 1918 LSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIK--DA 1972

Query: 178  ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237
            + T   NF + + VTY C  G      + L G  +I C ++    G WS    QC+  + 
Sbjct: 1973 VITGN-NFTFRNTVTYTCKEG------YTLAGLDTIECLAD----GKWSRSDQQCLAVSC 2021

Query: 238  CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP----ELPSC 293
              PP V++    + +R LF   ++  + C  G+ +    ++ C A  KW P    ++P C
Sbjct: 2022 DEPPIVDHASPETAHR-LFG--DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078

Query: 294  -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352
             +  C+ PP V ++      K  F+ G  V + C  G+ L  +A + C   G W+P+  +
Sbjct: 2079 IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS 2138

Query: 353  --CEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410
              C    C +    ++NG      N   GA V + C++GF +KG   S C   G    W+
Sbjct: 2139 IQCIPVRCGE-PPSIMNGYASGS-NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WS 2193

Query: 411  SSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 468
            S +P C  + C  PP + NG   HT   +    F   V Y C+P       +  +G    
Sbjct: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNP------GYKSVGSPVF 2243

Query: 469  RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY- 527
             C    Q N  W S +P   +   C  P       +K +    +F +G+ +++ C   Y 
Sbjct: 2244 VC----QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGE----NFEVGSKVQFFCNEGYE 2295

Query: 528  YGRPFSITCLDNLVW---SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTG 584
                 S TC  +  W   S+PK  C    C  PP   N +V      +VG  + +SC  G
Sbjct: 2296 LVGDSSWTCQKSGKWNKKSNPK--CMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEG 2352

Query: 585  HRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYR 644
            H L G S  +C+ S     W+   P+C+ + C  PP I+ G  I ++    H+GS V Y 
Sbjct: 2353 HVLQGPSVLKCLPS---QQWNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYS 2407

Query: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN-VENGILVSDNR 703
            C  G      F L G  +  C  +    G WS P P+C+ P +C  P  + NGI+  D +
Sbjct: 2408 CVGG------FFLRGNSTTLCQPD----GTWSSPLPECV-PVECPQPEEIPNGII--DVQ 2454

Query: 704  SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRD 762
             L  L+  + + C+PGF + G     C     W    P+C  + C  P ++L+ + +  D
Sbjct: 2455 GLAYLSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD 2513

Query: 763  KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF 822
                  GQ V YSC  G+ L G +++ C   GDW   AP+C    CD    Q +    + 
Sbjct: 2514 ---LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS--PQPIENGFVE 2568

Query: 823  PVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG-- 880
              +   GA + + C  GFQ+ G +   C     ES W+SS+P C  I C  PP I  G  
Sbjct: 2569 GADYSYGAIIIYSCFPGFQVAGHAMQTC----EESGWSSSIPTCMPIDCGLPPHIDFGDC 2624

Query: 881  ---------------------------RHTGKPLEV--------------FPFGKTVNYT 899
                                        H G   +               F +G  V+YT
Sbjct: 2625 TKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYT 2684

Query: 900  CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 959
            C+P       ++L+G   + C  D    G W+  AP C I   C  P     A       
Sbjct: 2685 CNP------GYELLGNPVLICQED----GTWNGSAPSC-ISIECDLPT----APENGFLR 2729

Query: 960  ASDFPIGTSLKYECRPEYYGRPFSI-TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI 1018
             ++  +G++++Y C+P +      +  CL+N  WS     C+  SCK P   +NG +   
Sbjct: 2730 FTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKG- 2788

Query: 1019 TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFI 1078
            ++    S + Y C  G+ L G     C    +  +W    PIC  + C  PP  ANG   
Sbjct: 2789 SNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPVDCSSPPVSANG--- 2842

Query: 1079 STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 1138
                + + +   + Y CN G      F L G  S  C +N    G WSG  P C+     
Sbjct: 2843 QVRGDEYTFQKEIEYTCNEG------FLLEGARSRVCLAN----GSWSGATPDCVPVRCA 2892

Query: 1139 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-C 1197
            TPP + NG+    +   +   + V F C  G+++ G  ++ CQ+   W+ E+P C  V C
Sbjct: 2893 TPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNC 2949

Query: 1198 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 1257
             PP D+ H      +  +F  G  + Y C PGY L G +S RC   G WS ++P+C    
Sbjct: 2950 GPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCR 3006

Query: 1258 CDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 1317
            C      ++    +   +   G      C +GF+L G S   C   G    W+S  P CE
Sbjct: 3007 CST---PVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGFPHCE 3060

Query: 1318 QIFCPSPPVIPNG--RHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQ 1375
               C S P+IPN     T    E       + Y+C       + + + G S + CT    
Sbjct: 3061 HTSCGSLPMIPNAFISETSSWKE-----NVITYSC------RSGYVIQGSSDLICTE--- 3106

Query: 1376 GNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFS 1433
              GVWS P P C  L  C +P     A    + +  +    + +K  C   Y       +
Sbjct: 3107 -KGVWSQPYPVCEPLS-CGSPPSVANAVATGEAHTYE----SEVKLRCLEGYTMDTDTDT 3160

Query: 1434 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSA 1493
             TC  +  W   +  C  K C  P +  + +VH   D  V  +++ SC  G+   G + +
Sbjct: 3161 FTCQKDGRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSVSCAEGYTFEGVNIS 3219

Query: 1494 ECILSGNTAHWSTKPPI----CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGS 1549
             C L G    W  +PP     C  + CG P +  +G  + +    + + S + Y+C  G 
Sbjct: 3220 VCQLDGT---W--EPPFSDESCSPVSCGKPESPEHGFVVGS---KYTFESTIIYQCEPG- 3270

Query: 1550 RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 1609
                 +EL G     C  N      WSG    C      TP    NG    +NR   +  
Sbjct: 3271 -----YELEGNRERVCQENRQ----WSGGVAICKETRCETPLEFLNGKADIENR---TTG 3318

Query: 1610 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPG 1669
              V + C  G+ ++GP    C     W   +P C     P P ++  E+    +  F   
Sbjct: 3319 PNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVI-PENALLSEKEFYVD 3377

Query: 1670 QEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPH--GRVLFPLNLQ 1727
            Q V   C  G+ L+G   + C P   W+  + +C   SC    G   H    +   ++ Q
Sbjct: 3378 QNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISC----GPPAHVENAIARGVHYQ 3433

Query: 1728 LGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI 1769
             G  +++ C  G+ L+G   S C+  G    W  S P+C  +
Sbjct: 3434 YGDMITYSCYSGYMLEGFLRSVCLENG---TW-TSPPICRAV 3471



 Score =  295 bits (756), Expect = 3e-79
 Identities = 231/834 (27%), Positives = 343/834 (41%), Gaps = 94/834 (11%)

Query: 49   LPFARPTNLTDEFEFPIGTYLNYECRPGY--SGRPFSIICLKNSVWTGAKDRCRRKSCRN 106
            LP A         E  +G+ + Y C+PG+  +G     +CL+N  W+GA  RC   SC+ 
Sbjct: 2719 LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLR-LCLENRKWSGASPRCEAISCKK 2777

Query: 107  PPDPVNGMVHVIKGIQFG--SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRI 164
            P   +NG    IKG  +   S + Y C  GY L G+   TC    D   WD + PIC  +
Sbjct: 2778 PNPVMNGS---IKGSNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPV 2831

Query: 165  PCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGI 224
             C  PP   NG       + + +   + Y CN G      F L G  S  C +N    G 
Sbjct: 2832 DCSSPPVSANG---QVRGDEYTFQKEIEYTCNEG------FLLEGARSRVCLAN----GS 2878

Query: 225  WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN 284
            WSG  P C+     TPP + NG+    +   +   + V F C  G+++ G  ++ CQ+  
Sbjct: 2879 WSGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDG 2935

Query: 285  KWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ 343
             W+ E+P C  V C PP D+ H      +  +F  G  + Y C PGY L G +S RC   
Sbjct: 2936 NWDAEIPLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSN 2992

Query: 344  GDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403
            G WS ++P+C    C      ++    +   +   G      C +GF+L G S   C   
Sbjct: 2993 GSWSGSSPSCLPCRCST---PVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEAD 3049

Query: 404  GMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
            G    W+S  P CE   C S P+IPN     T    E       + Y+C       + + 
Sbjct: 3050 GQ---WSSGFPHCEHTSCGSLPMIPNAFISETSSWKE-----NVITYSC------RSGYV 3095

Query: 462  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            + G S + CT      GVWS P P C  L  C +P     A    + +  +    + +K 
Sbjct: 3096 IQGSSDLICTE----KGVWSQPYPVCEPLS-CGSPPSVANAVATGEAHTYE----SEVKL 3146

Query: 522  ECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
             C   Y       + TC  +  W   +  C  K C  P +  + +VH   D  V  +++ 
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSV 3205

Query: 580  SCTTGHRLIGHSSAECILSGNAAHWSTKPPI----CQRIPCGLPPTIANGDFISTNRENF 635
            SC  G+   G + + C L G    W  +PP     C  + CG P +  +G  + +    +
Sbjct: 3206 SCAEGYTFEGVNISVCQLDGT---W--EPPFSDESCSPVSCGKPESPEHGFVVGS---KY 3257

Query: 636  HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695
             + S + Y+C PG      +EL G     C  N      WSG    C      TP    N
Sbjct: 3258 TFESTIIYQCEPG------YELEGNRERVCQENRQ----WSGGVAICKETRCETPLEFLN 3307

Query: 696  GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
            G    +NR   +    V + C  G+ ++GP    C     W   +P C     P P V+ 
Sbjct: 3308 GKADIENR---TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIP 3364

Query: 756  AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQL 815
                  +K+ F   Q V   C  G+ L+G   + C P   W+  +  CE  SC       
Sbjct: 3365 ENALLSEKE-FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGP--PAH 3421

Query: 816  LNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQI 869
            +   +   V+ Q G  + + C  G+ L+G   S C+  G    W +S P+C  +
Sbjct: 3422 VENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENG---TW-TSPPICRAV 3471



 Score =  282 bits (721), Expect = 3e-75
 Identities = 249/923 (26%), Positives = 363/923 (39%), Gaps = 139/923 (15%)

Query: 58   TDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115
            T    F  GT ++Y C PGY   G P  +IC ++  W G+   C    C  P  P NG +
Sbjct: 2670 THSSNFLYGTMVSYTCNPGYELLGNPV-LICQEDGTWNGSAPSCISIECDLPTAPENGFL 2728

Query: 116  HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175
               +    GS ++YSC  G+ L GS    C+   +   W   +P C+ I C  P  + NG
Sbjct: 2729 RFTE-TSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCEAISCKKPNPVMNG 2784

Query: 176  DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235
               S    N+ Y S + Y C+PG      + L G     C  + +    W    P CI  
Sbjct: 2785 ---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTCQDDKN----WDEDEPICIPV 2831

Query: 236  NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
            +  +PP   NG +  D    ++  + +E+ C  GF+++G R   C A   W    P C  
Sbjct: 2832 DCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVP 2888

Query: 296  V-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354
            V C  PP + +      D   +   +EV + C  GY L GA  + C   G+W    P C+
Sbjct: 2889 VRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945

Query: 355  VKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411
              +C   +D      NG      +   G  + + C  G++L G+S+  C+  G    W+ 
Sbjct: 2946 PVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS---WSG 2997

Query: 412  SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCT 471
            S P C    C S PVI  G   G     F  GK     C         F L+G S I C 
Sbjct: 2998 SSPSCLPCRC-STPVIEYGTVNGTD---FDCGKAARIQCFK------GFKLLGLSEITCE 3047

Query: 472  SDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS------LKYECRP 525
            +D    G WSS  P C         +H     L    NA  F   TS      + Y CR 
Sbjct: 3048 AD----GQWSSGFPHC---------EHTSCGSLPMIPNA--FISETSSWKENVITYSCRS 3092

Query: 526  EYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVN----GMVHVITDIQVGSRINYS 580
             Y  +  S + C +  VWS P  VC+  SC +PP   N    G  H        S +   
Sbjct: 3093 GYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYE-----SEVKLR 3147

Query: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN----GDFISTNRENFH 636
            C  G+ +   +  +         W  +   C    C LP  I +    GD  S NR+   
Sbjct: 3148 CLEGYTM--DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQ--- 3202

Query: 637  YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP-APQCIIPNKC-TPPNVE 694
                V+  C  G      +   G     C  +    G W  P + +   P  C  P + E
Sbjct: 3203 ----VSVSCAEG------YTFEGVNISVCQLD----GTWEPPFSDESCSPVSCGKPESPE 3248

Query: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDV 753
            +G +V    S ++    + ++C+PG+ ++G R   CQ   +W   +  C    C+ P + 
Sbjct: 3249 HGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEF 3305

Query: 754  LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-DFM 812
            L+ +    D +N + G  V YSC  GY L G +   CT  G WS   P C+   C   F+
Sbjct: 3306 LNGKA---DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFV 3362

Query: 813  GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCP 872
              +    +L      +   V   C EGF L+G     C     +  W  +   CE+I C 
Sbjct: 3363 --IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSAKCEKISCG 3417

Query: 873  SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 932
             P  + N    G     + +G  + Y+C       + + L G     C      NG W+S
Sbjct: 3418 PPAHVENAIARGVH---YQYGDMITYSC------YSGYMLEGFLRSVCLE----NGTWTS 3464

Query: 933  PAPRCGIL--------GHCQAPD 947
            P P C  +        G CQ P+
Sbjct: 3465 P-PICRAVCRFPCQNGGICQRPN 3486



 Score =  256 bits (653), Expect = 3e-67
 Identities = 216/811 (26%), Positives = 325/811 (40%), Gaps = 127/811 (15%)

Query: 1658 HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPH 1717
            H  +  ++  PG +V   C+PG+ L G    +C  QG W+   P C   SC    G  P 
Sbjct: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISC----GVPPP 1695

Query: 1718 GRVLFPL--NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVC--------- 1766
                F    +   G+ V++ C+ G+ L G S   C   G    WN   P C         
Sbjct: 1696 LENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVG 1752

Query: 1767 ----EHIFCPN----------PPAILNGRHTGTP--------------SGDI-PYGKEIS 1797
                EH  C N          PP   +G++   P              SG+I   G E++
Sbjct: 1753 SDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVT 1812

Query: 1798 YTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASP 1857
            ++C         + L+G + I C      +G W+   P C+ +V  G    PE       
Sbjct: 1813 FSCQE------GYQLMGVTKITCLE----SGEWNHLIPYCK-AVSCGKPAIPENG----- 1856

Query: 1858 TIPINDFEFPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNG 1916
               I +  F  G+ + Y C  GY        SCL N  WS     C    C   PE  N 
Sbjct: 1857 --CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCS-SPENINN 1913

Query: 1917 MVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTIS 1976
              +I +   + ST +YSC+ G+ L G     C  SG    WD+  P C ++ C  PP I 
Sbjct: 1914 GKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIK 1970

Query: 1977 NGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCI 2036
            +     NN T F N   VTY C  G      + L G  +I C +     G WS    +C+
Sbjct: 1971 DAVITGNNFT-FRN--TVTYTCKEG------YTLAGLDTIECLAD----GKWSRSDQQCL 2017

Query: 2037 STNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW----GPK 2092
            + +    P V++A     +R F    +I  + C  G+ +  +  + C   G+W    G  
Sbjct: 2018 AVSCDEPPIVDHASPETAHRLF---GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQD 2074

Query: 2093 LPHC-SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDW-- 2149
            +P C +  C+ PP + +       +  F+ G  V + C   + L  +A + C   G W  
Sbjct: 2075 MPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNP 2134

Query: 2150 SPEAPRCTVKSCDDFLGQLPH--GRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAG 2207
            SP + +C    C    G+ P          N   GA V++ C++GF +KG   S C   G
Sbjct: 2135 SPMSIQCIPVRC----GEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATG 2190

Query: 2208 MKALWNSSVPVCEQIFCPNPPAILNG--RHTGTPFGDIPYGKEISYACDTHPDRGMTFNL 2265
                W+S +P C  + C  PP + NG   HT    G I +  E+ Y C+        +  
Sbjct: 2191 Q---WSSPIPTCHPVSCGEPPKVENGFLEHT---TGRI-FESEVRYQCNP------GYKS 2237

Query: 2266 IGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISY 2325
            +G     C    Q N  W S +P   + VP  C  PP IQNG   G +  +   G  + +
Sbjct: 2238 VGSPVFVC----QANRHWHSESPL--MCVPLDCGKPPPIQNGFMKGENFEV---GSKVQF 2288

Query: 2326 ICDPGYLLVGKGFIFCTDQGIWSQLDH-YCKEVNCSFPLFMNGISKELEMKKVYHYGDYV 2384
             C+ GY LVG     C   G W++  +  C    C  P     +  +L +K++      V
Sbjct: 2289 FCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPL---LENQLVLKELTTEVGVV 2345

Query: 2385 TLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415
            T  C++G+ L+G    +C    +W+     C
Sbjct: 2346 TFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC 2376



 Score =  159 bits (401), Expect = 4e-38
 Identities = 118/393 (30%), Positives = 164/393 (41%), Gaps = 68/393 (17%)

Query: 2069 CQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFY 2127
            C PGF +VG+    C   G+W   LPHC R+ C  PP + +G H+    D+F  G  V Y
Sbjct: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA---DDFYAGSTVTY 1714

Query: 2128 SCEPSYDLRGAASLHCTPQGDWSPEAPRCT-VKSCDDFLGQLPHGRVL------------ 2174
             C   Y L G + + CT  G W+  +P C  V  C        H   L            
Sbjct: 1715 QCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774

Query: 2175 ----------------LPLNLQ----------LGAKVSFVCDEGFRLKGRSASHCVLAGM 2208
                             P N +          +GA+V+F C EG++L G +   C+ +G 
Sbjct: 1775 PYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE 1834

Query: 2209 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 2268
               WN  +P C+ + C  P    NG      F    +G +++Y C+    +G T  L G+
Sbjct: 1835 ---WNHLIPYCKAVSCGKPAIPENGCIEELAF---TFGSKVTYRCN----KGYT--LAGD 1882

Query: 2269 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 2328
                C +    N  WS   P CE   P  C  P  I NG YI   ++ YL   T SY CD
Sbjct: 1883 KESSCLA----NSSWSHSPPVCE---PVKCSSPENINNGKYILSGLT-YLS--TASYSCD 1932

Query: 2329 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKC 2388
             GY L G   I CT  GIW +    C  V C  P     I   +     + + + VT  C
Sbjct: 1933 TGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP---PAIKDAVITGNNFTFRNTVTYTC 1989

Query: 2389 EDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHD 2421
            ++GYTL G    +C AD +W     +C + + D
Sbjct: 1990 KEGYTLAGLDTIECLADGKWSRSDQQCLAVSCD 2022



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 48/167 (28%), Positives = 68/167 (40%), Gaps = 15/167 (8%)

Query: 2068 RCQPGFVMVGSHTVQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTLSHQDNFSPGQEVF 2126
            RC PGF +VGS  + C  NG W     +C  R C    +  HG  + S ++         
Sbjct: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYK-TTCL 463

Query: 2127 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN-----LQL 2181
             +C+  Y L G+  L C     W    PRC  + C  F  Q+P   ++ P N      + 
Sbjct: 464  VACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTF--QMPKDVIISPHNCGKQPAKF 521

Query: 2182 GAKVSFVCDEGFRLKG-RSASHCVLAGMKALWNSSV--PVCEQIFCP 2225
            G      C +GF L G +    C  +G    WN  V   VC+ +  P
Sbjct: 522  GTICYVSCRQGFILSGVKEMLRCTTSGK---WNVGVQAAVCKDVEAP 565



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 63/225 (28%), Positives = 90/225 (40%), Gaps = 43/225 (19%)

Query: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSV 190
           C +GYR  G +                   C+ + C       NG FI  N  N H+ + 
Sbjct: 362 CREGYRASGQT-------------------CELVHCPALKPPENGYFIQ-NTCNNHFNAA 401

Query: 191 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII---PNKCTPPNVENGI 247
              RC+PG      F+LVG   I C  N    G+WSG    C +   P+   P +    I
Sbjct: 402 CGVRCHPG------FDLVGSSIILCLPN----GLWSGSESYCRVRTCPHLRQPKH--GHI 449

Query: 248 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVC---QPPPDV 303
             S    L+    +V   C  G+ ++G  ++ CQ  ++W+   P C  R C   Q P DV
Sbjct: 450 SCSTREMLYKTTCLVA--CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDV 507

Query: 304 LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM-RCTPQGDWS 347
           + +      K     G   + SC  G+ L G   M RCT  G W+
Sbjct: 508 IISPH-NCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 24/195 (12%)

Query: 611 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
           C+ + C       NG FI  N  N H+ +    RC+PG      F+LVG   I C  N  
Sbjct: 373 CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423

Query: 671 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 727
             G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 424 --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477

Query: 728 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 783
           + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536

Query: 784 GAASM-RCTPQGDWS 797
           G   M RCT  G W+
Sbjct: 537 GVKEMLRCTTSGKWN 551



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 24/195 (12%)

Query: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 1120
            C+ + C       NG FI  N  N H+ +    RC+PG      F+LVG   I C  N  
Sbjct: 373  CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423

Query: 1121 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177
              G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 424  --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477

Query: 1178 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 1233
            + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 478  LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536

Query: 1234 GAASM-RCTPQGDWS 1247
            G   M RCT  G W+
Sbjct: 537  GVKEMLRCTTSGKWN 551



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 110/437 (25%), Positives = 161/437 (36%), Gaps = 81/437 (18%)

Query: 1639 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSP 1698
            EL  C  + +PP      ++T ++  N + G      C PG+DL G++ + C P G WS 
Sbjct: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428

Query: 1699 EAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFV-CDEGFRLKGSSVSHCVLVGMRS 1757
                C V++C   L Q  HG +       L      V CDEG+RL+GS    C      S
Sbjct: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484

Query: 1758 LWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIG 1814
             W+   P C    C     P  ++   H     G  P   +    C     +G   + + 
Sbjct: 485  QWDGPEPRCVERHCSTFQMPKDVIISPHN---CGKQP--AKFGTICYVSCRQGFILSGVK 539

Query: 1815 ESTIRCTSDPHGN-GVWS-------SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEF 1866
            E  +RCT+    N GV +       +P   C   + A   KT EQ   A+ T  I   + 
Sbjct: 540  E-MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEA---KTLEQQDSANVTWQIPTAKD 595

Query: 1867 PVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSC------------------ 1907
              G  ++    P +    +F I  +  +V+++ + +  + SC                  
Sbjct: 596  NSGEKVSVHVHPAFTPPYLFPIGDVA-IVYTATDLSGNQASCIFHIKVIDAEPPVIDWCR 654

Query: 1908 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS----------------TTCLVS 1951
             PPP   +  VH  +         +S N G  L+ + S                T    S
Sbjct: 655  SPPPVQVSEKVHAAS----WDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPS 710

Query: 1952 GNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELV 2011
            GNN T D    + +   CE P T  NGDF     T  + G   T  C  G D    F   
Sbjct: 711  GNNRTCDIHI-VIKGSPCEIPFTPVNGDFIC---TPDNTGVNCTLTCLEGYD----FTEG 762

Query: 2012 GERSIYCTSKDDQVGVW 2028
                 YC  +D   GVW
Sbjct: 763  STDKYYCAYED---GVW 776



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 54/195 (27%), Positives = 74/195 (37%), Gaps = 31/195 (15%)

Query: 2245 YGKEISYACDTHPDRGMTFNLIGE-----SSIRC-----TSDPQGNGV--------WSSP 2286
            YGK + Y C   P    T+   G      S I C     TS P             + + 
Sbjct: 312  YGKGLQYECTACPSG--TYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369

Query: 2287 APRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI 2346
               CEL     CP     +NG++I    + +         C PG+ LVG   I C   G+
Sbjct: 370  GQTCEL---VHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGSSIILCLPNGL 425

Query: 2347 WSQLDHYCKEVNCSF---PLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQ 2403
            WS  + YC+   C     P   +      EM     Y     + C++GY LEGS    CQ
Sbjct: 426  WSGSESYCRVRTCPHLRQPKHGHISCSTREML----YKTTCLVACDEGYRLEGSDKLTCQ 481

Query: 2404 ADDRWDPPLAKCTSR 2418
             + +WD P  +C  R
Sbjct: 482  GNSQWDGPEPRCVER 496



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 55/195 (28%), Positives = 81/195 (41%), Gaps = 24/195 (12%)

Query: 1511 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1570
            C+ + C       NG FI  N  N H+ +    RC+ G      F+LVG   I C  N  
Sbjct: 373  CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423

Query: 1571 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627
              G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 424  --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477

Query: 1628 VKCQALNKWEPELPSC-SRVC---QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLR 1683
            + CQ  ++W+   P C  R C   Q P +++   H    Q     G   + SC  G+ L 
Sbjct: 478  LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP-AKFGTICYVSCRQGFILS 536

Query: 1684 GAAS-LHCTPQGDWS 1697
            G    L CT  G W+
Sbjct: 537  GVKEMLRCTTSGKWN 551



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 72/289 (24%), Positives = 98/289 (33%), Gaps = 52/289 (17%)

Query: 2129 CEPSYDLRGAASLHCT--PQGDWSPEAPRCTVKSC---DDFLGQLPHGRVLLPLNLQLGA 2183
            CE  Y  +G     CT  P G + PE     + SC    D     P G           +
Sbjct: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST---------S 356

Query: 2184 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 2243
                VC EG+R  G++                   CE + CP      NG      F   
Sbjct: 357  PEDCVCREGYRASGQT-------------------CELVHCPALKPPENGY-----FIQN 392

Query: 2244 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 2303
                  + AC      G  F+L+G S I C      NG+WS     C +     CPH  +
Sbjct: 393  TCNNHFNAACGVRCHPG--FDLVGSSIILCLP----NGLWSGSESYCRVRT---CPHLRQ 443

Query: 2304 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 2363
             ++GH I       L   T    CD GY L G   + C     W   +  C E +CS   
Sbjct: 444  PKHGH-ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQ 502

Query: 2364 FMNG--ISKELEMKKVYHYGDYVTLKCEDGYTLEG-SPWSQCQADDRWD 2409
                  IS     K+   +G    + C  G+ L G     +C    +W+
Sbjct: 503  MPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 55/226 (24%), Positives = 85/226 (37%), Gaps = 24/226 (10%)

Query: 1902 CRRKSCGPPPEPFNGMVHINT-DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1960
            C    C     P NG    NT +  F +     C+ GF L+GS    CL +G    W   
Sbjct: 373  CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG---LWSGS 429

Query: 1961 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 2020
               C + +C       +G    + R   +  T +   C  G      + L G   + C  
Sbjct: 430  ESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV-ACDEG------YRLEGSDKLTCQG 482

Query: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGN--RSFFTLTEIIRFRCQPGFVMVG- 2077
                   W  P PRC+  +  T    ++ I  P N  +       I    C+ GF++ G 
Sbjct: 483  NSQ----WDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGV 538

Query: 2078 SHTVQCQTNGRW--GPKLPHCSRVCQPP---PEILHGEHTLSHQDN 2118
               ++C T+G+W  G +   C  V  P    P+ +  + TL  QD+
Sbjct: 539  KEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAK-TLEQQDS 583



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 39/134 (29%), Positives = 59/134 (44%), Gaps = 10/134 (7%)

Query: 2092 KLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 2151
            +L HC  + +PP      ++T ++  N + G      C P +DL G++ + C P G WS 
Sbjct: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428

Query: 2152 EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFV-CDEGFRLKGRSASHCVLAGMKA 2210
                C V++C   L Q  HG +       L      V CDEG+RL+G     C      +
Sbjct: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484

Query: 2211 LWNSSVPVCEQIFC 2224
             W+   P C +  C
Sbjct: 485  QWDGPEPRCVERHC 498



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428

Query: 349 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 407
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484

Query: 408 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536

Query: 464 G-ESTIRCTSDPQGN 477
           G +  +RCT+  + N
Sbjct: 537 GVKEMLRCTTSGKWN 551



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 739 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428

Query: 799 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 857
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484

Query: 858 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 913
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536

Query: 914 G-ESTIRCTSDPQGN 927
           G +  +RCT+  + N
Sbjct: 537 GVKEMLRCTTSGKWN 551



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 1189 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 1248
            EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428

Query: 1249 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 1307
            +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484

Query: 1308 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 1363
             W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 485  QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536

Query: 1364 G-ESTIRCTSDPQGN 1377
            G +  +RCT+  + N
Sbjct: 537  GVKEMLRCTTSGKWN 551



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 13/177 (7%)

Query: 73  CRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV-IKGIQFGSQIKYS 130
           C PG+     SII CL N +W+G++  CR ++C +   P +G +    + + + +    +
Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465

Query: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITNGDFISTNRENFHY 187
           C +GYRL GS   TC   G++  WD   P C    C    +P  +      +  ++   +
Sbjct: 466 CDEGYRLEGSDKLTC--QGNSQ-WDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKF 521

Query: 188 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 244
           G++    C  G     +   V E     TS    VG+ +        P    P ++E
Sbjct: 522 GTICYVSCRQGF----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 60/231 (25%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 266 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 322
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361

Query: 323 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 382
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402

Query: 383 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 442
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+  +
Sbjct: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-Y 458

Query: 443 GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493
             T    CD        + L G   + C    QGN  W  P PRC +  HC
Sbjct: 459 KTTCLVACDE------GYRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 60/231 (25%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 716 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 772
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361

Query: 773 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 832
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402

Query: 833 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 892
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+  +
Sbjct: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-Y 458

Query: 893 GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 943
             T    CD        + L G   + C    QGN  W  P PRC +  HC
Sbjct: 459 KTTCLVACDE------GYRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498



 Score = 45.4 bits (106), Expect = 7e-04
 Identities = 61/231 (26%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 1166 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 1222
            C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 307  CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361

Query: 1223 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 1282
               C  GY   G                 TCE+  C           +    N    A  
Sbjct: 362  ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402

Query: 1283 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 1342
               C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+   
Sbjct: 403  GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-- 457

Query: 1343 GKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 1393
                  TC    D G  + L G   + C    QGN  W  P PRC +  HC
Sbjct: 458  ---YKTTCLVACDEG--YRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 55/236 (23%), Positives = 77/236 (32%), Gaps = 47/236 (19%)

Query: 1226 CEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVD 1283
            CE GY  +G     CT  P G + P      + SC     +        P +    +  D
Sbjct: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDE---NHTSPPGST---SPED 359

Query: 1284 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG 1343
             VC EG++  G +                   CE + CP+     NG           F 
Sbjct: 360  CVCREGYRASGQT-------------------CELVHCPALKPPENGYFIQNTCNNH-FN 399

Query: 1344 KAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI--LGHCQAPDHFLF 1401
             A    C P       FDL+G S I C      NG+WS     C +    H + P H   
Sbjct: 400  AACGVRCHP------GFDLVGSSIILCLP----NGLWSGSESYCRVRTCPHLRQPKHGHI 449

Query: 1402 AKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKT 1456
            +      +  +    T+    C   Y       +TC  N  W  P+  C  + C T
Sbjct: 450  S-----CSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCST 500



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 12/165 (7%)

Query: 534 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 592
           I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 593 AECILSGNAAHWSTKPPICQRIPCG---LPPTIANGDFISTNRENFHYGSVVTYRCNPGS 649
             C   GN + W    P C    C    +P  +      +  ++   +G++    C  G 
Sbjct: 478 LTC--QGN-SQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGF 533

Query: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 694
               +   V E     TS    VG+ +        P    P ++E
Sbjct: 534 ----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 12/165 (7%)

Query: 984  ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 1042
            I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 418  ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 1043 AECILSGNAAHWSTKPPICQRIPCG---LPPTIANGDFISTNRENFHYGSVVTYRCNPGS 1099
              C   GN + W    P C    C    +P  +      +  ++   +G++    C  G 
Sbjct: 478  LTC--QGN-SQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGF 533

Query: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1144
                +   V E     TS    VG+ +        P    P ++E
Sbjct: 534  ----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 4/84 (4%)

Query: 1434 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 1492
            I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 418  ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 1493 AECILSGNTAHWSTKPPICQRIPC 1516
              C   GN + W    P C    C
Sbjct: 478  LTC--QGN-SQWDGPEPRCVERHC 498


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
            isoform 2 [Homo sapiens]
          Length = 1033

 Score =  603 bits (1555), Expect = e-172
 Identities = 372/1048 (35%), Positives = 501/1048 (47%), Gaps = 126/1048 (12%)

Query: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
            I CG PP I NG  IS        G+V+ Y C+        F L+GE S+ C + D   G
Sbjct: 21   ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73

Query: 1574 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
             W  PAP+C   NK   C  P V  G  +  +   +   + V F C+  F M G + V C
Sbjct: 74   TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132

Query: 1631 QALNKWEP-ELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
            QA N W P  LP+C  V    C   P I +G HT  +  + +PG  V YSCE GY L G 
Sbjct: 133  QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192

Query: 1686 ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGS 1745
              ++C   G WS   P C    C   LG+ P+G+V  P  L++G   +F CDEG+RL+G 
Sbjct: 193  KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251

Query: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
              S CV+ G    W   +PVCE IFCP+PP ILNGRH G    ++ YG  ++YTCDP P+
Sbjct: 252  PSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310

Query: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE--------------- 1850
             G+ F LIGEST+RCT D    G WS PAPRCELS  A  C  P+               
Sbjct: 311  EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370

Query: 1851 ---------QFPFA---------------SPTIPINDFE-------------------FP 1867
                      F F                 P+ P+ + E                   F 
Sbjct: 371  YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFD 430

Query: 1868 VGTSLNYECRPGYF--GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1925
             GTS+ Y C PGY   G+  SI C    VW+     C+  +C    E     +      Q
Sbjct: 431  PGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCKVAAC----EATGRQLLTKPQHQ 485

Query: 1926 F-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNN 1984
            F    VN SC EG++L GS    C      + W  +  +C+ I+C PPP I NG    ++
Sbjct: 486  FVRPDVNSSCGEGYKLSGSVYQECQ---GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSS 542

Query: 1985 RTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC---ISTNKC 2041
               F  GT VTY C+ GP+    F L+GE +I CTS D + G WS P P C   +   +C
Sbjct: 543  LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR-VC 2100
            +   + N  ++ G  + +   + + F+C  GF + GS  ++C+ +  W P++P C +  C
Sbjct: 603  SHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC 662

Query: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC--TPQGDWSPEAPRCTV 2158
            Q      H   +L      S  + V  SC+  Y L G A   C     G W  + P C V
Sbjct: 663  Q------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKV 716

Query: 2159 KSCDDFLGQLPHGRV--LLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM-KALWNSS 2215
              C      + +G+   ++  N   G +VS+ CD+GF L G     C         W+  
Sbjct: 717  IHCHP-PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGP 775

Query: 2216 VPVCEQ----IFCPNPPAI----LNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 2267
             P C +      CPNP       LN  H+     DI Y        D +P     F + G
Sbjct: 776  SPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY-------VDCNPG----FIMNG 824

Query: 2268 ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYIC 2327
               IRC +D      W    P C       CP PPK  NG++ GG+++ + PGM+I Y C
Sbjct: 825  SRVIRCHTD----NTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSC 880

Query: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLK 2387
            D GYLLVG+  + CT +G WSQ   +CKEVNCS P  M+GI K LE +K+Y YG  VTL+
Sbjct: 881  DQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLE 940

Query: 2388 CEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILK 2447
            CEDGY LEGSP SQCQ+D +W+PPLA C SR+   ++ G  +G I    LI+   ++I K
Sbjct: 941  CEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISK 1000

Query: 2448 HRKGNNAHENPKEVAIHLHSQGGSSVHP 2475
            HR  N   +  ++ A HL ++   SV P
Sbjct: 1001 HRARNYYTDTSQKEAFHLEAREVYSVDP 1028



 Score =  560 bits (1444), Expect = e-159
 Identities = 329/981 (33%), Positives = 483/981 (49%), Gaps = 70/981 (7%)

Query: 815  LLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG-MESLWNSSVPVCEQI--- 869
            +LNGR+  +   + +G  + + C   F+L G  +  C+    ++  W+   P CE     
Sbjct: 29   ILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKY 88

Query: 870  -FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG 928
              CP P ++P G +  +    +  G +V + C       T+F + G  ++ C    Q N 
Sbjct: 89   SSCPEP-IVPGG-YKIRGSTPYRHGDSVTFACK------TNFSMNGNKSVWC----QANN 136

Query: 929  VWS-SPAPRCGILGHCQAPD-HFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSI 984
            +W  +  P C  +   + P    +     T  N      G S+ Y C   Y   G    I
Sbjct: 137  MWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI-I 195

Query: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044
             CL +  WS+    C+   CK+     NG V     ++VG   N+ C  G+RL G  S+ 
Sbjct: 196  NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255

Query: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104
            C+++G    W TK P+C+ I C  PP I NG  I  +  N  YGS+VTY C+P       
Sbjct: 256  CVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314

Query: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPPNVENGILVSDNRSLFSLNEV 1161
            F L+GE ++ CT +  + G WSGPAP+C +     +C  P +  G +VS  +  ++ N+ 
Sbjct: 315  FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374

Query: 1162 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 1221
            V F C  GF +KG ++++C A   WEP  P C + CQ PP++L+ ++  R    F PG  
Sbjct: 375  VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTS 434

Query: 1222 VFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAK 1281
            + YSC PGY L G  S++CT +G W+P  P C+V +C+    QLL      P +  +   
Sbjct: 435  IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK----PQHQFVRPD 490

Query: 1282 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 1341
            V+  C EG++L GS    C        W   + +C++I CP PPVI NG HTG  LE FP
Sbjct: 491  VNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547

Query: 1342 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 1401
            +G  V YTC+P P+RG  F LIGESTIRCTS+ Q  G WS PAP C +        H   
Sbjct: 548  YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI 607

Query: 1402 AK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPD 1459
            A   K     + +    ++ ++C   +  +  S I C  +  W     VC++++C+    
Sbjct: 608  ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ---- 663

Query: 1460 PVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQR 1513
                  HV   + ++  GSR   +N SC  G++L GH+   C        W  K P+C+ 
Sbjct: 664  ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC-QDAENGIWFKKIPLCKV 716

Query: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
            I C  PP I NG       ENF YG+ V+Y C+ G      F L+GE  + C S+    G
Sbjct: 717  IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHG 770

Query: 1574 IWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
             WSGP+PQC+      +C  P V++G  ++   S +S N++V   C PGF+M G R ++C
Sbjct: 771  SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830

Query: 1631 QALNKWEPELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
               N W P +P+C +     C PPP+  +G HT  +   FSPG  + YSC+ GY L G A
Sbjct: 831  HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890

Query: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL-QLGAKVSFVCDEGFRLKGS 1745
             L CT +G WS  AP C   +C          + L P  + Q GA V+  C++G+ L+GS
Sbjct: 891  LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950

Query: 1746 SVSHCVLVGMRSLWNNSVPVC 1766
              S C        WN  + VC
Sbjct: 951  PQSQC---QSDHQWNPPLAVC 968



 Score =  523 bits (1348), Expect = e-148
 Identities = 292/825 (35%), Positives = 421/825 (51%), Gaps = 56/825 (6%)

Query: 66  GTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFG 124
           G  + Y C  GY      II CL +  W+     C    C++     NG V     ++ G
Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235

Query: 125 SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNREN 184
               + C +GYRL G  S+ C+I+G  V W  + P+C+ I C  PP I NG  I  +  N
Sbjct: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294

Query: 185 FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPP 241
             YGS+VTY C+P       F L+GE ++ CT +  + G WSGPAP+C +     +C  P
Sbjct: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354

Query: 242 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
            +  G +VS  +  ++ N+ V F C  GF +KG ++++C A   WEP  P C + CQ PP
Sbjct: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414

Query: 302 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
           ++L+ ++  R    F PG  + YSC PGY L G  S++CT +G W+P  P C+V +C+  
Sbjct: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474

Query: 362 MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 421
             QLL      P +  +   V+  C EG++L GS    C        W   + +C++I C
Sbjct: 475 GRQLLTK----PQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527

Query: 422 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
           P PPVI NG HTG  LE FP+G TV YTC+P P+RG  F LIGESTIRCTS+ Q  G WS
Sbjct: 528 PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS 587

Query: 482 SPAPRCGILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDN 539
            PAP C +        H   A   K     + +    ++ ++C   +  +  S I C  +
Sbjct: 588 GPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD 647

Query: 540 LVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSA 593
             W     VC++++C+          HV   + ++  GSR   +N SC  G++L GH+  
Sbjct: 648 NTWDPEIPVCEKETCQ----------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQ 697

Query: 594 ECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRK 653
            C  + N   W  K P+C+ I C  PP I NG       ENF YG+ V+Y C+ G     
Sbjct: 698 MCQDAENGI-WFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG----- 751

Query: 654 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNE 710
            F L+GE  + C S+    G WSGP+PQC+      +C  P V++G  ++   S +S N+
Sbjct: 752 -FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHND 810

Query: 711 VVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV----CQPPPDVLHAERTQRDKDNF 766
           +V   C PGF+M G R ++C   N W P +P+C +     C PPP   +   T  +   F
Sbjct: 811 IVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARF 870

Query: 767 SPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-----DFMGQLLNGRVL 821
           SPG  + YSC+ GY L G A + CT +G WS  AP C+  +C      D + + L  R +
Sbjct: 871 SPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM 930

Query: 822 FPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
           +    Q GA V   C++G+ L+GS  S C     +  WN  + VC
Sbjct: 931 Y----QYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968



 Score =  447 bits (1151), Expect = e-125
 Identities = 307/969 (31%), Positives = 428/969 (44%), Gaps = 121/969 (12%)

Query: 164  IPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 223
            I CG PP I NG  IS        G+V+ Y C+        F L+GE S+ C + D   G
Sbjct: 21   ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCSG------TFRLIGEKSLLCITKDKVDG 73

Query: 224  IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 280
             W  PAP+C   NK   C  P V  G  +  +   +   + V F C+  F M G + V C
Sbjct: 74   TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132

Query: 281  QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
            QA N W P  LP+C  V    C   P + +   T  +  + +PG  V YSCE GY L G 
Sbjct: 133  QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192

Query: 336  ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGS 395
              + C   G WS   PTCE   C   +G+  NG+V  P  L++G   +F CDEG++L+G 
Sbjct: 193  KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251

Query: 396  SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
             +S CV+AG    W + +PVCE+IFCPSPP I NGRH G  L    +G  V YTCDP P+
Sbjct: 252  PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310

Query: 456  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI-LGHCQAPDHFLFAKLKTQTNASDFP 514
             G +F LIGEST+RCT D Q  G WS PAPRC +     Q P   +            + 
Sbjct: 311  EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370

Query: 515  IGTSLKYECRPEYYGR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV---HVITD 570
               ++ + C   +  +    I C     W     VC+ K C+ PP+ +NG     H++  
Sbjct: 371  YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDRHMVR- 428

Query: 571  IQVGSRINYSCTTGHRLIGHSSAECILSG----------------NAAHWSTKPP----- 609
               G+ I YSC  G+ L+G  S +C   G                      TKP      
Sbjct: 429  FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR 488

Query: 610  --------------------------------ICQRIPCGLPPTIANGDFISTNRENFHY 637
                                            +C+ I C  PP I NG    ++ E+F Y
Sbjct: 489  PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPY 548

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVE 694
            G+ VTY CNPG      F L+GE +I CTSND + G WSGPAP C   ++  +C+  ++ 
Sbjct: 549  GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608

Query: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR-VCQPPPDV 753
            NG  +S   + +  N+ V F+C  GF +KG  +++C+A N W+PE+P C +  CQ     
Sbjct: 609  NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ----- 663

Query: 754  LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC--TPQGDWSPAAPTCEVKSCDDF 811
             H  ++ ++    S  + V  SC+ GY L G A   C     G W    P C+V  C   
Sbjct: 664  -HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP- 721

Query: 812  MGQLLNGR--VLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCEQ 868
               ++NG+   +   N   G +V + CD+GF L G     C         W+   P C +
Sbjct: 722  PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLR 781

Query: 869  ----IFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDP 924
                  CP+P V  +G    K    +     V   C+P       F + G   IRC +D 
Sbjct: 782  SPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNP------GFIMNGSRVIRCHTD- 833

Query: 925  QGNGVWSSPAPRC---GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YG 979
                 W    P C     +G C  P         T  N + F  G S+ Y C   Y   G
Sbjct: 834  ---NTWVPGVPTCIKKAFIG-CPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVG 888

Query: 980  RPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD---IQVGSRINYSCTTGHR 1036
                + C     WS P   CK  +C +P D ++G+   +      Q G+ +   C  G+ 
Sbjct: 889  EAL-LLCTHEGTWSQPAPHCKEVNCSSPAD-MDGIQKGLEPRKMYQYGAVVTLECEDGYM 946

Query: 1037 LIGHSSAEC 1045
            L G   ++C
Sbjct: 947  LEGSPQSQC 955



 Score =  365 bits (937), Expect = e-100
 Identities = 280/1002 (27%), Positives = 417/1002 (41%), Gaps = 155/1002 (15%)

Query: 1319 IFCPSPPVIPNGR--HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 1376
            I C SPP I NGR  +   P+ V   G  + Y+C      GT F LIGE ++ C +  + 
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAV---GTVIRYSCS-----GT-FRLIGEKSLLCITKDKV 71

Query: 1377 NGVWSSPAPRCGILG-HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSI 1434
            +G W  PAP+C     +   P+  +    K +  ++ +  G S+ + C+  +      S+
Sbjct: 72   DGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR-GSTPYRHGDSVTFACKTNFSMNGNKSV 130

Query: 1435 TCLDNLVWSSPK-DVCKR---KSCKTPPDPVNG--MVHVITDIQVGSRINYSCTTGHRLI 1488
             C  N +W   +   C       C   P   NG      +  I  G  + YSC +G+ L+
Sbjct: 131  WCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV 190

Query: 1489 GHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLG 1548
            G     C+ SG    WS  PP C+   C       NG            G    + C+ G
Sbjct: 191  GEKIINCLSSGK---WSAVPPTCEEARCKSLGRFPNGKV--KEPPILRVGVTANFFCDEG 245

Query: 1549 SRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 1608
                  + L G PS  C      V  W+   P C      +PP + NG  + ++ +  S 
Sbjct: 246  ------YRLQGPPSSRCVIAGQGVA-WT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSY 297

Query: 1609 NEVVEFRCQP------GFVMKGPRRVKC----QALNKWEPELPSC----SRVCQPPPEIL 1654
              +V + C P       F++ G   ++C    Q    W    P C    S V  P P+IL
Sbjct: 298  GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357

Query: 1655 HGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD---DF 1711
             G      +D ++    V ++C  G+ L+G+  + C  QG W P AP C  K C    + 
Sbjct: 358  RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNI 416

Query: 1712 LGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFC 1771
            L      R +  +    G  + + C+ G+ L G     C   G   +W   VP C+   C
Sbjct: 417  LNGQKEDRHM--VRFDPGTSIKYSCNPGYVLVGEESIQCTSEG---VWTPPVPQCKVAAC 471

Query: 1772 ----------PNPPAI-------------LNGRHTGTPSGDIPYGKEI------------ 1796
                      P    +             L+G       G IP+  EI            
Sbjct: 472  EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP 531

Query: 1797 ---------------------SYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1835
                                 +YTC+P P+RG+ F+LIGESTIRCTS+    G WS PAP
Sbjct: 532  VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591

Query: 1836 RCELS---VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS-ISCLE 1891
             C+LS   V+  H      +  +    P     +    ++ ++C  G+  K  S I C  
Sbjct: 592  LCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFKCYSGFTLKGSSQIRCKA 646

Query: 1892 NLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ---FGS---TVNYSCNEGFRLIGSPS 1945
            +  W      C +++C           H+    Q    GS    VN SC +G++L G   
Sbjct: 647  DNTWDPEIPVCEKETC----------QHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAY 696

Query: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005
              C  + N + W KK P+C++I C PPP I NG        +F  G  V+Y+C  G    
Sbjct: 697  QMCQDAENGI-WFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG---- 751

Query: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRCIST---NKCTAPEVENAIRVPGNRSFFTLT 2062
              F L+GE+ + C S     G WS P P+C+ +    +C  PEV++  ++    S ++  
Sbjct: 752  --FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHN 809

Query: 2063 EIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV----CQPPPEILHGEHTLSHQDN 2118
            +I+   C PGF+M GS  ++C T+  W P +P C +     C PPP+  +G HT  +   
Sbjct: 810  DIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIAR 869

Query: 2119 FSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN 2178
            FSPG  + YSC+  Y L G A L CT +G WS  AP C   +C          + L P  
Sbjct: 870  FSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRK 929

Query: 2179 L-QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC 2219
            + Q GA V+  C++G+ L+G   S C        WN  + VC
Sbjct: 930  MYQYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968



 Score =  256 bits (654), Expect = 2e-67
 Identities = 258/1044 (24%), Positives = 397/1044 (38%), Gaps = 149/1044 (14%)

Query: 297  CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ----GDWSPAAPT 352
            C  PP +L+  R        + G  + YSC   + L G  S+ C  +    G W   AP 
Sbjct: 23   CGSPPPILNG-RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 353  CEV----KSCDDFM---GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
            CE      SC + +   G  + G   +    + G  V F C   F + G+ + +C    M
Sbjct: 82   CEYFNKYSSCPEPIVPGGYKIRGSTPY----RHGDSVTFACKTNFSMNGNKSVWCQANNM 137

Query: 406  ESLWNSS-VPVCEQIF---CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
               W  + +P C  +F   CP+ P+I NG HT + +     G +V Y+C+      + + 
Sbjct: 138  ---WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCE------SGYL 188

Query: 462  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            L+GE  I C S    +G WS+  P C     C++   F   K+K         +G +  +
Sbjct: 189  LVGEKIINCLS----SGKWSAVPPTCEE-ARCKSLGRFPNGKVK---EPPILRVGVTANF 240

Query: 522  ECRPEY--YGRPFS--ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVG 574
             C   Y   G P S  +     + W+    VC+   C +PP  +NG  H+   + ++  G
Sbjct: 241  FCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGR-HIGNSLANVSYG 298

Query: 575  SRINYSCTTGHR------LIGHSSAECIL-SGNAAHWSTKPPICQRIPCGLP---PTIAN 624
            S + Y+C           LIG S+  C + S     WS   P C+     +    P I  
Sbjct: 299  SIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILR 358

Query: 625  GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 684
            G  +S  ++ + Y   V + C  G      F L G   I C +     G W   AP C  
Sbjct: 359  GRMVSGQKDRYTYNDTVIFACMFG------FTLKGSKQIRCNAQ----GTWEPSAPVC-- 406

Query: 685  PNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
              +C  PPN+ NG     +   F     +++ C PG+V+ G   ++C +   W P +P C
Sbjct: 407  EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466

Query: 744  SRVCQPPPDVLHAERTQRDKDNFSPGQ----EVFYSCEPGYDLRGAASMRCTPQGDWSPA 799
                     V   E T R        Q    +V  SC  GY L G+    C     W   
Sbjct: 467  K--------VAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFME 518

Query: 800  APTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEG------FQLKGSSASYCV 851
               C+  +C      + NG        +   G  V + C+ G      F L G S   C 
Sbjct: 519  IRLCKEITCPP-PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCT 577

Query: 852  LAGME-SLWNSSVPVCE----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDR 906
                E   W+   P+C+     + C    +    + +GK    F +  TV + C      
Sbjct: 578  SNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYF-YNDTVTFKCY----- 631

Query: 907  GTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966
             + F L G S IRC +D      W    P C     CQ            + +  + P G
Sbjct: 632  -SGFTLKGSSQIRCKAD----NTWDPEIPVCE-KETCQ----------HVRQSLQELPAG 675

Query: 967  TSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDPVNGMVH--V 1017
            + ++     C+  Y   G  + + C D  N +W     +CK   C  PP  VNG     +
Sbjct: 676  SRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMM 734

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP----CGLPPT 1071
              +   G+ ++Y C  G  L+G    +C  S +  H  WS   P C R P    C   P 
Sbjct: 735  AENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPPVTRCP-NPE 792

Query: 1072 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131
            + +G  ++     + +  +V   CNPG      F + G   I C +++     W    P 
Sbjct: 793  VKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGVPT 842

Query: 1132 CI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP 1188
            CI         PP   NG     N + FS    + + C  G+++ G   + C     W  
Sbjct: 843  CIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQ 902

Query: 1189 ELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 1247
              P C  V C  P D+   ++    +  +  G  V   CE GY L G+   +C     W+
Sbjct: 903  PAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWN 962

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVL 1271
            P    C  +S    +  +  G +L
Sbjct: 963  PPLAVCRSRSLAPVLCGIAAGLIL 986



 Score =  229 bits (584), Expect = 3e-59
 Identities = 176/589 (29%), Positives = 252/589 (42%), Gaps = 67/589 (11%)

Query: 37  PVAWGQCNAPEWLPFARPTNLTDEFE------FPIGTYLNYECRPGY--SGRPFSIICLK 88
           PV   +C AP       P  L  + E      F  GT + Y C PGY   G   SI C  
Sbjct: 404 PVCEKECQAP-------PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE-SIQCTS 455

Query: 89  NSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSATCII 147
             VWT    +C+  +C    +     +      QF    +  SC +GY+L GS    C  
Sbjct: 456 EGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC-- 509

Query: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFEL 207
              T+ W  E  +C  I C  PP I NG    ++ E+F YG+ VTY CNPG      F L
Sbjct: 510 -QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568

Query: 208 VGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
           +GE +I CTSND + G WSGPAP C   ++  +C+  ++ NG  +S   + +  N+ V F
Sbjct: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTF 628

Query: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSR-VCQPPPDVLHAERTQRDKDNFSPGQEVF 323
           +C  GF +KG  +++C+A N W+PE+P C +  CQ      H  ++ ++    S  + V 
Sbjct: 629 KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ------HVRQSLQELPAGSRVELVN 682

Query: 324 YSCEPGYDLRGAASMRC--TPQGDWSPAAPTCEVKSCDDFMGQLLNGR--VLFPVNLQLG 379
            SC+ GY L G A   C     G W    P C+V  C      ++NG+   +   N   G
Sbjct: 683 TSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP-PPVIVNGKHTGMMAENFLYG 741

Query: 380 AKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCEQ----IFCPSPPVIPNGRHTG 434
            +V + CD+GF L G     C         W+   P C +      CP+P V  +G    
Sbjct: 742 NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLN 800

Query: 435 KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---GILG 491
           K    +     V   C+P       F + G   IRC +D      W    P C     +G
Sbjct: 801 KTHSAYSHNDIVYVDCNP------GFIMNGSRVIRCHTD----NTWVPGVPTCIKKAFIG 850

Query: 492 HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVC 549
            C  P         T  N + F  G S+ Y C   Y   G    + C     WS P   C
Sbjct: 851 -CPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVGEAL-LLCTHEGTWSQPAPHC 907

Query: 550 KRKSCKTPPDPVNGMVHVITD---IQVGSRINYSCTTGHRLIGHSSAEC 595
           K  +C +P D ++G+   +      Q G+ +   C  G+ L G   ++C
Sbjct: 908 KEVNCSSPAD-MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC 955



 Score =  198 bits (503), Expect = 6e-50
 Identities = 199/811 (24%), Positives = 302/811 (37%), Gaps = 112/811 (13%)

Query: 65  IGTYLNYECRPGY--SGRPFS--IICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV--- 117
           +G   N+ C  GY   G P S  +I  +   WT     C    C +PP  +NG  H+   
Sbjct: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGR-HIGNS 291

Query: 118 IKGIQFGSQIKYSCTK------GYRLIGSSSATCII-SGDTVIWDNETPICDRIPCGLP- 169
           +  + +GS + Y+C         + LIG S+  C + S  T  W    P C+     +  
Sbjct: 292 LANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC 351

Query: 170 --PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 227
             P I  G  +S  ++ + Y   V + C  G      F L G   I C +     G W  
Sbjct: 352 PHPQILRGRMVSGQKDRYTYNDTVIFACMFG------FTLKGSKQIRCNAQ----GTWEP 401

Query: 228 PAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 286
            AP C    +C  PPN+ NG     +   F     +++ C PG+V+ G   ++C +   W
Sbjct: 402 SAPVC--EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVW 459

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ----EVFYSCEPGYDLRGAASMRCTP 342
            P +P C         V   E T R        Q    +V  SC  GY L G+    C  
Sbjct: 460 TPPVPQCK--------VAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQG 511

Query: 343 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEG------FQLKG 394
              W      C+  +C      + NG        +   G  V + C+ G      F L G
Sbjct: 512 TIPWFMEIRLCKEITCPP-PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570

Query: 395 SSASYCVLAGME-SLWNSSVPVCE----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYT 449
            S   C     E   W+   P+C+     + C    +    + +GK    F +  TV + 
Sbjct: 571 ESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYF-YNDTVTFK 629

Query: 450 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
           C       + F L G S IRC +D      W    P C     CQ            + +
Sbjct: 630 CY------SGFTLKGSSQIRCKAD----NTWDPEIPVCE-KETCQ----------HVRQS 668

Query: 510 ASDFPIGTSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDPVN 562
             + P G+ ++     C+  Y   G  + + C D  N +W     +CK   C  PP  VN
Sbjct: 669 LQELPAGSRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVIVN 727

Query: 563 GMVH--VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP--- 615
           G     +  +   G+ ++Y C  G  L+G    +C  S +  H  WS   P C R P   
Sbjct: 728 GKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPPVT 786

Query: 616 -CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGI 674
            C   P + +G  ++     + +  +V   CNPG      F + G   I C +++     
Sbjct: 787 RCP-NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT---- 835

Query: 675 WSGPAPQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731
           W    P CI         PP   NG     N + FS    + + C  G+++ G   + C 
Sbjct: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCT 895

Query: 732 ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 790
               W    P C  V C  P D+   ++    +  +  G  V   CE GY L G+   +C
Sbjct: 896 HEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC 955

Query: 791 TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL 821
                W+P    C  +S    +  +  G +L
Sbjct: 956 QSDHQWNPPLAVCRSRSLAPVLCGIAAGLIL 986



 Score =  191 bits (486), Expect = 6e-48
 Identities = 132/438 (30%), Positives = 191/438 (43%), Gaps = 97/438 (22%)

Query: 62  EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTG---------------- 94
           +FP GT + Y C PG   G  FS+I      C  N      W+G                
Sbjct: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604

Query: 95  -----------------------------------AKDRCRRKSCRNPPDPV---NGMVH 116
                                              ++ RC+  +  +P  PV       H
Sbjct: 605 VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQH 664

Query: 117 VIKGIQ---FGSQIKY---SCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPP 170
           V + +Q    GS+++    SC  GY+L G +   C    +  IW  + P+C  I C  PP
Sbjct: 665 VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC-QDAENGIWFKKIPLCKVIHCHPPP 723

Query: 171 TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 230
            I NG       ENF YG+ V+Y C+ G      F L+GE  + C S+    G WSGP+P
Sbjct: 724 VIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHGSWSGPSP 777

Query: 231 QCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 287
           QC+      +C  P V++G  ++   S +S N++V   C PGF+M G R ++C   N W 
Sbjct: 778 QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWV 837

Query: 288 PELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ 343
           P +P+C +     C PPP   +   T  +   FSPG  + YSC+ GY L G A + CT +
Sbjct: 838 PGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHE 897

Query: 344 GDWSPAAPTCEVKSCD-----DFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSAS 398
           G WS  AP C+  +C      D + + L  R ++    Q GA V   C++G+ L+GS  S
Sbjct: 898 GTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMY----QYGAVVTLECEDGYMLEGSPQS 953

Query: 399 YCVLAGMESLWNSSVPVC 416
            C     +  WN  + VC
Sbjct: 954 QC---QSDHQWNPPLAVC 968



 Score =  100 bits (249), Expect = 2e-20
 Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 28/327 (8%)

Query: 62  EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115
           E P G+    +N  C+ GY  +G  + +    +N +W      C+   C  PP  VNG  
Sbjct: 671 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 730

Query: 116 H--VIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWDNETPICDRIP----CGL 168
              + +   +G+++ Y C +G+ L+G     C   S     W   +P C R P    C  
Sbjct: 731 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP- 789

Query: 169 PPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 228
            P + +G  ++     + +  +V   CNPG      F + G   I C +++     W   
Sbjct: 790 NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPG 839

Query: 229 APQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
            P CI         PP   NG     N + FS    + + C  G+++ G   + C     
Sbjct: 840 VPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT 899

Query: 286 WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
           W    P C  V C  P D+   ++    +  +  G  V   CE GY L G+   +C    
Sbjct: 900 WSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH 959

Query: 345 DWSPAAPTCEVKSCDDFMGQLLNGRVL 371
            W+P    C  +S    +  +  G +L
Sbjct: 960 QWNPPLAVCRSRSLAPVLCGIAAGLIL 986


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
            isoform 1 [Homo sapiens]
          Length = 1092

 Score =  603 bits (1555), Expect = e-172
 Identities = 378/1101 (34%), Positives = 509/1101 (46%), Gaps = 173/1101 (15%)

Query: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
            I CG PP I NG  IS        G+V+ Y C+        F L+GE S+ C + D   G
Sbjct: 21   ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73

Query: 1574 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
             W  PAP+C   NK   C  P V  G  +  +   +   + V F C+  F M G + V C
Sbjct: 74   TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132

Query: 1631 QALNKWEP-ELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
            QA N W P  LP+C  V    C   P I +G HT  +  + +PG  V YSCE GY L G 
Sbjct: 133  QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192

Query: 1686 ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGS 1745
              ++C   G WS   P C    C   LG+ P+G+V  P  L++G   +F CDEG+RL+G 
Sbjct: 193  KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251

Query: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
              S CV+ G    W   +PVCE IFCP+PP ILNGRH G    ++ YG  ++YTCDP P+
Sbjct: 252  PSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310

Query: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE--------------- 1850
             G+ F LIGEST+RCT D    G WS PAPRCELS  A  C  P+               
Sbjct: 311  EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370

Query: 1851 ---------QFPFA---------------SPTIPINDFE-------------------FP 1867
                      F F                 P+ P+ + E                   F 
Sbjct: 371  YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFD 430

Query: 1868 VGTSLNYECRPGYF--GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1925
             GTS+ Y C PGY   G+  SI C    VW+     C+  +C    E     +      Q
Sbjct: 431  PGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCKVAAC----EATGRQLLTKPQHQ 485

Query: 1926 F-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNN 1984
            F    VN SC EG++L GS    C      + W  +  +C+ I+C PPP I NG    ++
Sbjct: 486  FVRPDVNSSCGEGYKLSGSVYQECQ---GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSS 542

Query: 1985 RTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC---ISTNKC 2041
               F  GT VTY C+ GP+    F L+GE +I CTS D + G WS P P C   +   +C
Sbjct: 543  LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQ 2101
            +   + N  ++ G  + +   + + F+C  GF + GS  ++C+ +  W P++P C + CQ
Sbjct: 603  SHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQ 662

Query: 2102 PPPEILHGEHTLSH------------------------------QDNFSPG--------- 2122
             PP + HG HT  +                                N+SP          
Sbjct: 663  SPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQ 722

Query: 2123 ---------------QEVFYSCEPSYDLRGAASLHC--TPQGDWSPEAPRCTVKSCDDFL 2165
                           + V  SC+  Y L G A   C     G W  + P C V  C    
Sbjct: 723  HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP-P 781

Query: 2166 GQLPHGRV--LLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM-KALWNSSVPVCEQ- 2221
              + +G+   ++  N   G +VS+ CD+GF L G     C         W+   P C + 
Sbjct: 782  PVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRS 841

Query: 2222 ---IFCPNPPAI----LNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCT 2274
                 CPNP       LN  H+     DI Y        D +P     F + G   IRC 
Sbjct: 842  PPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY-------VDCNPG----FIMNGSRVIRCH 890

Query: 2275 SDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLV 2334
            +D      W    P C       CP PPK  NG++ GG+++ + PGM+I Y CD GYLLV
Sbjct: 891  TD----NTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV 946

Query: 2335 GKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTL 2394
            G+  + CT +G WSQ   +CKEVNCS P  M+GI K LE +K+Y YG  VTL+CEDGY L
Sbjct: 947  GEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYML 1006

Query: 2395 EGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNA 2454
            EGSP SQCQ+D +W+PPLA C SR+   ++ G  +G I    LI+   ++I KHR  N  
Sbjct: 1007 EGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYY 1066

Query: 2455 HENPKEVAIHLHSQGGSSVHP 2475
             +  ++ A HL ++   SV P
Sbjct: 1067 TDTSQKEAFHLEAREVYSVDP 1087



 Score =  557 bits (1435), Expect = e-158
 Identities = 351/1051 (33%), Positives = 486/1051 (46%), Gaps = 126/1051 (11%)

Query: 164  IPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 223
            I CG PP I NG  IS        G+V+ Y C+        F L+GE S+ C + D   G
Sbjct: 21   ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCSG------TFRLIGEKSLLCITKDKVDG 73

Query: 224  IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 280
             W  PAP+C   NK   C  P V  G  +  +   +   + V F C+  F M G + V C
Sbjct: 74   TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132

Query: 281  QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
            QA N W P  LP+C  V    C   P + +   T  +  + +PG  V YSCE GY L G 
Sbjct: 133  QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192

Query: 336  ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGS 395
              + C   G WS   PTCE   C   +G+  NG+V  P  L++G   +F CDEG++L+G 
Sbjct: 193  KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251

Query: 396  SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
             +S CV+AG    W + +PVCE+IFCPSPP I NGRH G  L    +G  V YTCDP P+
Sbjct: 252  PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310

Query: 456  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI-LGHCQAPDHFLFAKLKTQTNASDFP 514
             G +F LIGEST+RCT D Q  G WS PAPRC +     Q P   +            + 
Sbjct: 311  EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370

Query: 515  IGTSLKYECRPEYYGR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV---HVITD 570
               ++ + C   +  +    I C     W     VC+ K C+ PP+ +NG     H++  
Sbjct: 371  YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDRHMVR- 428

Query: 571  IQVGSRINYSCTTGHRLIGHSSAECILSG----------------NAAHWSTKPP----- 609
               G+ I YSC  G+ L+G  S +C   G                      TKP      
Sbjct: 429  FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR 488

Query: 610  --------------------------------ICQRIPCGLPPTIANGDFISTNRENFHY 637
                                            +C+ I C  PP I NG    ++ E+F Y
Sbjct: 489  PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPY 548

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVE 694
            G+ VTY CNPG      F L+GE +I CTSND + G WSGPAP C   ++  +C+  ++ 
Sbjct: 549  GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608

Query: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVL 754
            NG  +S   + +  N+ V F+C  GF +KG  +++C+A N W+PE+P C + CQ PP + 
Sbjct: 609  NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLH 668

Query: 755  HAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQ 814
            H   T  +   F  G  V Y+C+PGY L G  S+ C P G+WSP+AP CE ++C      
Sbjct: 669  HGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE-ETCQHVRQS 727

Query: 815  LLNGRVLFPVNLQLGAKVDFV---CDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871
            L          L  G++V+ V   C +G+QL G +   C  A    +W   +P+C+ I C
Sbjct: 728  L--------QELPAGSRVELVNTSCQDGYQLTGHAYQMCQDA-ENGIWFKKIPLCKVIHC 778

Query: 872  PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
              PPVI NG+HTG   E F +G  V+Y CD        F L+GE  ++C SD +G+G WS
Sbjct: 779  HPPPVIVNGKHTGMMAENFLYGNEVSYECD------QGFYLLGEKKLQCRSDSKGHGSWS 832

Query: 932  SPAPRC---GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCL 987
             P+P+C     +  C  P+  +    K     S +     +  +C P +       I C 
Sbjct: 833  GPSPQCLRSPPVTRCPNPE--VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCH 890

Query: 988  DNLVWSSPKDVCKRKS---CKTPPDPVNGMVHV---ITDIQVGSRINYSCTTGHRLIGHS 1041
             +  W      C +K+   C  PP   NG  H    I     G  I YSC  G+ L+G +
Sbjct: 891  TDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVGEA 949

Query: 1042 SAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGG 1101
               C   G    WS   P C+ + C  P  +         R+ + YG+VVT  C  G   
Sbjct: 950  LLLCTHEGT---WSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDG--- 1003

Query: 1102 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 1132
               + L G P   C S+      W+ P   C
Sbjct: 1004 ---YMLEGSPQSQCQSDHQ----WNPPLAVC 1027



 Score =  549 bits (1414), Expect = e-155
 Identities = 334/1031 (32%), Positives = 487/1031 (47%), Gaps = 111/1031 (10%)

Query: 815  LLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG-MESLWNSSVPVCEQI--- 869
            +LNGR+  +   + +G  + + C   F+L G  +  C+    ++  W+   P CE     
Sbjct: 29   ILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKY 88

Query: 870  -FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG 928
              CP P ++P G +  +    +  G +V + C       T+F + G  ++ C    Q N 
Sbjct: 89   SSCPEP-IVPGG-YKIRGSTPYRHGDSVTFACK------TNFSMNGNKSVWC----QANN 136

Query: 929  VWS-SPAPRCGILGHCQAPD-HFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSI 984
            +W  +  P C  +   + P    +     T  N      G S+ Y C   Y   G    I
Sbjct: 137  MWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI-I 195

Query: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044
             CL +  WS+    C+   CK+     NG V     ++VG   N+ C  G+RL G  S+ 
Sbjct: 196  NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255

Query: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104
            C+++G    W TK P+C+ I C  PP I NG  I  +  N  YGS+VTY C+P       
Sbjct: 256  CVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314

Query: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPPNVENGILVSDNRSLFSLNEV 1161
            F L+GE ++ CT +  + G WSGPAP+C +     +C  P +  G +VS  +  ++ N+ 
Sbjct: 315  FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374

Query: 1162 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 1221
            V F C  GF +KG ++++C A   WEP  P C + CQ PP++L+ ++  R    F PG  
Sbjct: 375  VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTS 434

Query: 1222 VFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAK 1281
            + YSC PGY L G  S++CT +G W+P  P C+V +C+    QLL      P +  +   
Sbjct: 435  IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK----PQHQFVRPD 490

Query: 1282 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 1341
            V+  C EG++L GS    C        W   + +C++I CP PPVI NG HTG  LE FP
Sbjct: 491  VNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547

Query: 1342 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 1401
            +G  V YTC+P P+RG  F LIGESTIRCTS+ Q  G WS PAP C +        H   
Sbjct: 548  YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI 607

Query: 1402 AK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPD 1459
            A   K     + +    ++ ++C   +  +  S I C  +  W     VC+ K C++PP 
Sbjct: 608  ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE-KGCQSPPG 666

Query: 1460 PVNGMVHV---ITDIQVGSRINYSCTTGHRLIGHSSAECILSGN---------------- 1500
              +G  H          G  ++Y+C  G+ L+G+ S  C+ SGN                
Sbjct: 667  LHHGR-HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVR 725

Query: 1501 -------------------------TAH------------WSTKPPICQRIPCGLPPTIA 1523
                                     T H            W  K P+C+ I C  PP I 
Sbjct: 726  QSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIV 785

Query: 1524 NGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1583
            NG       ENF YG+ V+Y C+ G      F L+GE  + C S+    G WSGP+PQC+
Sbjct: 786  NGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHGSWSGPSPQCL 839

Query: 1584 IP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL 1640
                  +C  P V++G  ++   S +S N++V   C PGF+M G R ++C   N W P +
Sbjct: 840  RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 899

Query: 1641 PSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDW 1696
            P+C +     C PPP+  +G HT  +   FSPG  + YSC+ GY L G A L CT +G W
Sbjct: 900  PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 959

Query: 1697 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNL-QLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            S  AP C   +C          + L P  + Q GA V+  C++G+ L+GS  S C     
Sbjct: 960  SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC---QS 1016

Query: 1756 RSLWNNSVPVC 1766
               WN  + VC
Sbjct: 1017 DHQWNPPLAVC 1027



 Score =  504 bits (1298), Expect = e-142
 Identities = 295/878 (33%), Positives = 421/878 (47%), Gaps = 103/878 (11%)

Query: 66   GTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFG 124
            G  + Y C  GY      II CL +  W+     C    C++     NG V     ++ G
Sbjct: 176  GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235

Query: 125  SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNREN 184
                + C +GYRL G  S+ C+I+G  V W  + P+C+ I C  PP I NG  I  +  N
Sbjct: 236  VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294

Query: 185  FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPP 241
              YGS+VTY C+P       F L+GE ++ CT +  + G WSGPAP+C +     +C  P
Sbjct: 295  VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354

Query: 242  NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
             +  G +VS  +  ++ N+ V F C  GF +KG ++++C A   WEP  P C + CQ PP
Sbjct: 355  QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414

Query: 302  DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
            ++L+ ++  R    F PG  + YSC PGY L G  S++CT +G W+P  P C+V +C+  
Sbjct: 415  NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474

Query: 362  MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 421
              QLL      P +  +   V+  C EG++L GS    C        W   + +C++I C
Sbjct: 475  GRQLLTK----PQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527

Query: 422  PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
            P PPVI NG HTG  LE FP+G TV YTC+P P+RG  F LIGESTIRCTS+ Q  G WS
Sbjct: 528  PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS 587

Query: 482  SPAPRCGILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDN 539
             PAP C +        H   A   K     + +    ++ ++C   +  +  S I C  +
Sbjct: 588  GPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD 647

Query: 540  LVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVGSRINYSCTTGHRLIGHSSAECI 596
              W     VC+ K C++PP   +G  H          G  ++Y+C  G+ L+G+ S  C+
Sbjct: 648  NTWDPEIPVCE-KGCQSPPGLHHGR-HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCM 705

Query: 597  LSGNAAHWSTKPPIC-----------QRIPCGL--------------------------- 618
             SGN   WS   P C           Q +P G                            
Sbjct: 706  PSGN---WSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAE 762

Query: 619  ------------------PPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE 660
                              PP I NG       ENF YG+ V+Y C+ G      F L+GE
Sbjct: 763  NGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGE 816

Query: 661  PSIYCTSNDDQVGIWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQ 717
              + C S+    G WSGP+PQC+      +C  P V++G  ++   S +S N++V   C 
Sbjct: 817  KKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCN 876

Query: 718  PGFVMKGPRRVKCQALNKWEPELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVF 773
            PGF+M G R ++C   N W P +P+C +     C PPP   +   T  +   FSPG  + 
Sbjct: 877  PGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSIL 936

Query: 774  YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-----DFMGQLLNGRVLFPVNLQL 828
            YSC+ GY L G A + CT +G WS  AP C+  +C      D + + L  R ++    Q 
Sbjct: 937  YSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMY----QY 992

Query: 829  GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
            GA V   C++G+ L+GS  S C     +  WN  + VC
Sbjct: 993  GAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 1027



 Score =  365 bits (936), Expect = e-100
 Identities = 288/1052 (27%), Positives = 425/1052 (40%), Gaps = 196/1052 (18%)

Query: 1319 IFCPSPPVIPNGR--HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 1376
            I C SPP I NGR  +   P+ V   G  + Y+C      GT F LIGE ++ C +  + 
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAV---GTVIRYSCS-----GT-FRLIGEKSLLCITKDKV 71

Query: 1377 NGVWSSPAPRCGILG-HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSI 1434
            +G W  PAP+C     +   P+  +    K +  ++ +  G S+ + C+  +      S+
Sbjct: 72   DGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR-GSTPYRHGDSVTFACKTNFSMNGNKSV 130

Query: 1435 TCLDNLVWSSPK-DVCKR---KSCKTPPDPVNG--MVHVITDIQVGSRINYSCTTGHRLI 1488
             C  N +W   +   C       C   P   NG      +  I  G  + YSC +G+ L+
Sbjct: 131  WCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV 190

Query: 1489 GHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLG 1548
            G     C+ SG    WS  PP C+   C       NG            G    + C+ G
Sbjct: 191  GEKIINCLSSGK---WSAVPPTCEEARCKSLGRFPNGKV--KEPPILRVGVTANFFCDEG 245

Query: 1549 SRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 1608
                  + L G PS  C      V  W+   P C      +PP + NG  + ++ +  S 
Sbjct: 246  ------YRLQGPPSSRCVIAGQGVA-WT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSY 297

Query: 1609 NEVVEFRCQP------GFVMKGPRRVKC----QALNKWEPELPSC----SRVCQPPPEIL 1654
              +V + C P       F++ G   ++C    Q    W    P C    S V  P P+IL
Sbjct: 298  GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357

Query: 1655 HGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD---DF 1711
             G      +D ++    V ++C  G+ L+G+  + C  QG W P AP C  K C    + 
Sbjct: 358  RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNI 416

Query: 1712 LGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFC 1771
            L      R +  +    G  + + C+ G+ L G     C   G   +W   VP C+   C
Sbjct: 417  LNGQKEDRHM--VRFDPGTSIKYSCNPGYVLVGEESIQCTSEG---VWTPPVPQCKVAAC 471

Query: 1772 ----------PNPPAI-------------LNGRHTGTPSGDIPYGKEI------------ 1796
                      P    +             L+G       G IP+  EI            
Sbjct: 472  EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP 531

Query: 1797 ---------------------SYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1835
                                 +YTC+P P+RG+ F+LIGESTIRCTS+    G WS PAP
Sbjct: 532  VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591

Query: 1836 RCELS---VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS-ISCLE 1891
             C+LS   V+  H      +  +    P     +    ++ ++C  G+  K  S I C  
Sbjct: 592  LCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFKCYSGFTLKGSSQIRCKA 646

Query: 1892 NLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTC 1948
            +  W      C  K C  PP   +G  H   +T F   G TV+Y+C+ G+ L+G+ S  C
Sbjct: 647  DNTWDPEIPVC-EKGCQSPPGLHHGR-HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHC 704

Query: 1949 LVSGN-----------------------------------------------------NV 1955
            + SGN                                                     N 
Sbjct: 705  MPSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENG 764

Query: 1956 TWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERS 2015
             W KK P+C++I C PPP I NG        +F  G  V+Y+C  G      F L+GE+ 
Sbjct: 765  IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKK 818

Query: 2016 IYCTSKDDQVGVWSSPPPRCIST---NKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG 2072
            + C S     G WS P P+C+ +    +C  PEV++  ++    S ++  +I+   C PG
Sbjct: 819  LQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPG 878

Query: 2073 FVMVGSHTVQCQTNGRWGPKLPHCSRV----CQPPPEILHGEHTLSHQDNFSPGQEVFYS 2128
            F+M GS  ++C T+  W P +P C +     C PPP+  +G HT  +   FSPG  + YS
Sbjct: 879  FIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYS 938

Query: 2129 CEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL-QLGAKVSF 2187
            C+  Y L G A L CT +G WS  AP C   +C          + L P  + Q GA V+ 
Sbjct: 939  CDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTL 998

Query: 2188 VCDEGFRLKGRSASHCVLAGMKALWNSSVPVC 2219
             C++G+ L+G   S C        WN  + VC
Sbjct: 999  ECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 1027



 Score =  338 bits (868), Expect = 3e-92
 Identities = 220/671 (32%), Positives = 310/671 (46%), Gaps = 72/671 (10%)

Query: 37   PVAWGQCNAPEWLPFARPTNLTDEFE------FPIGTYLNYECRPGY--SGRPFSIICLK 88
            PV   +C AP       P  L  + E      F  GT + Y C PGY   G   SI C  
Sbjct: 404  PVCEKECQAP-------PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE-SIQCTS 455

Query: 89   NSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSATCII 147
              VWT    +C+  +C    +     +      QF    +  SC +GY+L GS    C  
Sbjct: 456  EGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC-- 509

Query: 148  SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFEL 207
               T+ W  E  +C  I C  PP I NG    ++ E+F YG+ VTY CNPG      F L
Sbjct: 510  -QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568

Query: 208  VGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
            +GE +I CTSND + G WSGPAP C   ++  +C+  ++ NG  +S   + +  N+ V F
Sbjct: 569  IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTF 628

Query: 265  RCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 324
            +C  GF +KG  +++C+A N W+PE+P C + CQ PP + H   T  +   F  G  V Y
Sbjct: 629  KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDY 688

Query: 325  SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384
            +C+PGY L G  S+ C P G+WSP+AP CE ++C      L          L  G++V+ 
Sbjct: 689  TCDPGYLLVGNKSIHCMPSGNWSPSAPRCE-ETCQHVRQSL--------QELPAGSRVEL 739

Query: 385  V---CDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 441
            V   C +G+QL G +   C  A    +W   +P+C+ I C  PPVI NG+HTG   E F 
Sbjct: 740  VNTSCQDGYQLTGHAYQMCQDA-ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFL 798

Query: 442  FGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDH 498
            +G  V+Y CD        F L+GE  ++C SD +G+G WS P+P+C     +  C  P+ 
Sbjct: 799  YGNEVSYECD------QGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE- 851

Query: 499  FLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKS---C 554
             +    K     S +     +  +C P +       I C  +  W      C +K+   C
Sbjct: 852  -VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 910

Query: 555  KTPPDPVNGMVHV---ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 611
              PP   NG  H    I     G  I YSC  G+ L+G +   C   G    WS   P C
Sbjct: 911  PPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT---WSQPAPHC 966

Query: 612  QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
            + + C  P  +         R+ + YG+VVT  C  G      + L G P   C S+   
Sbjct: 967  KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDG------YMLEGSPQSQCQSDHQ- 1019

Query: 672  VGIWSGPAPQC 682
               W+ P   C
Sbjct: 1020 ---WNPPLAVC 1027



 Score =  310 bits (795), Expect = 9e-84
 Identities = 285/1099 (25%), Positives = 436/1099 (39%), Gaps = 144/1099 (13%)

Query: 239  TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC- 293
            +PP + NG  +S   +  ++  V+ + C   F + G + + C   +K    W+   P C 
Sbjct: 25   SPPPILNG-RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCE 83

Query: 294  --SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAA- 350
              ++    P  ++      R    +  G  V ++C+  + + G  S+ C     W P   
Sbjct: 84   YFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRL 143

Query: 351  PTCEVK---SCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
            PTC       C   +  + NG        ++  G  V + C+ G+ L G     C+ +G 
Sbjct: 144  PTCVSVFPLECPA-LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK 202

Query: 406  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
               W++  P CE+  C S    PNG+    P  +   G T N+ CD        + L G 
Sbjct: 203  ---WSAVPPTCEEARCKSLGRFPNGKVKEPP--ILRVGVTANFFCDE------GYRLQGP 251

Query: 466  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
             + RC     G GV  +  P C  +  C +P   L  +     + ++   G+ + Y C P
Sbjct: 252  PSSRCVI--AGQGVAWTKMPVCEEI-FCPSPPPILNGR-HIGNSLANVSYGSIVTYTCDP 307

Query: 526  E--------YYGRPFSITCLDNL---VWSSPKDVCKRKS----CKTPPDPVNGMVHVITD 570
            +          G       +D+     WS P   C+  +    C  P      MV    D
Sbjct: 308  DPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367

Query: 571  -IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIS 629
                   + ++C  G  L G     C   G    W    P+C++  C  PP I NG    
Sbjct: 368  RYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVCEK-ECQAPPNILNGQKED 423

Query: 630  TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 689
             +   F  G+ + Y CNPG      + LVGE SI CTS     G+W+ P PQC    K  
Sbjct: 424  RHMVRFDPGTSIKYSCNPG------YVLVGEESIQCTSE----GVWTPPVPQC----KVA 469

Query: 690  PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQ 748
                    L++  +  F +   V   C  G+ + G    +CQ    W  E+  C  + C 
Sbjct: 470  ACEATGRQLLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCP 528

Query: 749  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPG------YDLRGAASMRCTP----QGDWSP 798
            PPP + +   T    ++F  G  V Y+C PG      + L G +++RCT     +G WS 
Sbjct: 529  PPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSG 588

Query: 799  AAPTCEVK----SCDDFM---GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCV 851
             AP C++      C       G  ++G+            V F C  GF LKGSS   C 
Sbjct: 589  PAPLCKLSLLAVQCSHVHIANGYKISGK---EAPYFYNDTVTFKCYSGFTLKGSSQIRCK 645

Query: 852  LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 911
                ++ W+  +PVCE+  C SPP + +GRHTG     F  G TV+YTCDP       + 
Sbjct: 646  A---DNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDP------GYL 695

Query: 912  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 971
            L+G  +I C   P GN  WS  APRC     CQ            + +  + P G+ ++ 
Sbjct: 696  LVGNKSIHCM--PSGN--WSPSAPRCEET--CQ----------HVRQSLQELPAGSRVEL 739

Query: 972  ---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDPVNGMVH--VITDIQ 1022
                C+  Y   G  + + C D  N +W     +CK   C  PP  VNG     +  +  
Sbjct: 740  VNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFL 798

Query: 1023 VGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP----CGLPPTIANGD 1076
             G+ ++Y C  G  L+G    +C  S +  H  WS   P C R P    C   P + +G 
Sbjct: 799  YGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPPVTRCP-NPEVKHGY 856

Query: 1077 FISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--- 1133
             ++     + +  +V   CNPG      F + G   I C +++     W    P CI   
Sbjct: 857  KLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGVPTCIKKA 906

Query: 1134 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1193
                  PP   NG     N + FS    + + C  G+++ G   + C     W    P C
Sbjct: 907  FIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 966

Query: 1194 SRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 1252
              V C  P D+   ++    +  +  G  V   CE GY L G+   +C     W+P    
Sbjct: 967  KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 1026

Query: 1253 CEVKSCDDFMGQLLNGRVL 1271
            C  +S    +  +  G +L
Sbjct: 1027 CRSRSLAPVLCGIAAGLIL 1045



 Score =  264 bits (674), Expect = 9e-70
 Identities = 222/809 (27%), Positives = 328/809 (40%), Gaps = 114/809 (14%)

Query: 66   GTYLNYECRP-----------GYSGRPFSIICLKNSVWTGAKDRCRRKS----CRNPPDP 110
            G+ + Y C P           G S    ++   K   W+G   RC   +    C +P   
Sbjct: 298  GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357

Query: 111  VNGMVHVIKG-IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLP 169
               MV   K    +   + ++C  G+ L GS    C   G    W+   P+C++  C  P
Sbjct: 358  RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVCEK-ECQAP 413

Query: 170  PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 229
            P I NG     +   F  G+ + Y CNPG      + LVGE SI CTS     G+W+ P 
Sbjct: 414  PNILNGQKEDRHMVRFDPGTSIKYSCNPG------YVLVGEESIQCTSE----GVWTPPV 463

Query: 230  PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 289
            PQC    K          L++  +  F +   V   C  G+ + G    +CQ    W  E
Sbjct: 464  PQC----KVAACEATGRQLLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFME 518

Query: 290  LPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG------YDLRGAASMRCTP 342
            +  C  + C PPP + +   T    ++F  G  V Y+C PG      + L G +++RCT 
Sbjct: 519  IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578

Query: 343  ----QGDWSPAAPTCEVK----SCDDFM---GQLLNGRVLFPVNLQLGAKVDFVCDEGFQ 391
                +G WS  AP C++      C       G  ++G+            V F C  GF 
Sbjct: 579  NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK---EAPYFYNDTVTFKCYSGFT 635

Query: 392  LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 451
            LKGSS   C     ++ W+  +PVCE+  C SPP + +GRHTG     F  G TV+YTCD
Sbjct: 636  LKGSSQIRCKA---DNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCD 691

Query: 452  PHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNAS 511
            P       + L+G  +I C   P GN  WS  APRC     CQ            + +  
Sbjct: 692  P------GYLLVGNKSIHCM--PSGN--WSPSAPRCEET--CQ----------HVRQSLQ 729

Query: 512  DFPIGTSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDPVNGM 564
            + P G+ ++     C+  Y   G  + + C D  N +W     +CK   C  PP  VNG 
Sbjct: 730  ELPAGSRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVIVNGK 788

Query: 565  VH--VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP----C 616
                +  +   G+ ++Y C  G  L+G    +C  S +  H  WS   P C R P    C
Sbjct: 789  HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPPVTRC 847

Query: 617  GLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWS 676
               P + +G  ++     + +  +V   CNPG      F + G   I C +++     W 
Sbjct: 848  P-NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WV 896

Query: 677  GPAPQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 733
               P CI         PP   NG     N + FS    + + C  G+++ G   + C   
Sbjct: 897  PGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHE 956

Query: 734  NKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 792
              W    P C  V C  P D+   ++    +  +  G  V   CE GY L G+   +C  
Sbjct: 957  GTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQS 1016

Query: 793  QGDWSPAAPTCEVKSCDDFMGQLLNGRVL 821
               W+P    C  +S    +  +  G +L
Sbjct: 1017 DHQWNPPLAVCRSRSLAPVLCGIAAGLIL 1045



 Score =  175 bits (443), Expect = 6e-43
 Identities = 151/534 (28%), Positives = 220/534 (41%), Gaps = 89/534 (16%)

Query: 62   EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTGAKDRCRRK----SCRN 106
            +FP GT + Y C PG   G  FS+I      C  N      W+G    C+       C +
Sbjct: 545  DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604

Query: 107  PPDPVNGMVHVIKGIQ---------FGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
                    VH+  G +         +   + + C  G+ L GSS   C        WD E
Sbjct: 605  --------VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN---TWDPE 653

Query: 158  TPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
             P+C++  C  PP + +G     N   F  G  V Y C+PG      + LVG  SI+C  
Sbjct: 654  IPVCEK-GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPG------YLLVGNKSIHCMP 706

Query: 218  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
            +    G WS  AP+C     C         L + +R      E+V   CQ G+ + G   
Sbjct: 707  S----GNWSPSAPRC--EETCQHVRQSLQELPAGSRV-----ELVNTSCQDGYQLTGHAY 755

Query: 278  VKCQALNK--WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 334
              CQ      W  ++P C  + C PPP +++ + T    +NF  G EV Y C+ G+ L G
Sbjct: 756  QMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLG 815

Query: 335  AASMRCTP----QGDWSPAAPTC----EVKSCDDFMGQLLNGRVLFPVNLQLGAK--VDF 384
               ++C       G WS  +P C     V  C +   ++ +G  L   +        V  
Sbjct: 816  EKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN--PEVKHGYKLNKTHSAYSHNDIVYV 873

Query: 385  VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ---IFCPSPPVIPNGRHTGKPLEVFP 441
             C+ GF + GS    C     ++ W   VP C +   I CP PP  PNG HTG  +  F 
Sbjct: 874  DCNPGFIMNGSRVIRC---HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFS 930

Query: 442  FGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 501
             G ++ Y+CD        + L+GE+ + CT +    G WS PAP C  + +C +P   + 
Sbjct: 931  PGMSILYSCD------QGYLLVGEALLLCTHE----GTWSQPAPHCKEV-NCSSPAD-MD 978

Query: 502  AKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKS 553
               K       +  G  +  EC   Y   G P S  C  +  W+ P  VC+ +S
Sbjct: 979  GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS-QCQSDHQWNPPLAVCRSRS 1031



 Score =  100 bits (249), Expect = 2e-20
 Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 28/327 (8%)

Query: 62   EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115
            E P G+    +N  C+ GY  +G  + +    +N +W      C+   C  PP  VNG  
Sbjct: 730  ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 789

Query: 116  H--VIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWDNETPICDRIP----CGL 168
               + +   +G+++ Y C +G+ L+G     C   S     W   +P C R P    C  
Sbjct: 790  TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP- 848

Query: 169  PPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 228
             P + +G  ++     + +  +V   CNPG      F + G   I C +++     W   
Sbjct: 849  NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPG 898

Query: 229  APQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
             P CI         PP   NG     N + FS    + + C  G+++ G   + C     
Sbjct: 899  VPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT 958

Query: 286  WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
            W    P C  V C  P D+   ++    +  +  G  V   CE GY L G+   +C    
Sbjct: 959  WSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH 1018

Query: 345  DWSPAAPTCEVKSCDDFMGQLLNGRVL 371
             W+P    C  +S    +  +  G +L
Sbjct: 1019 QWNPPLAVCRSRSLAPVLCGIAAGLIL 1045


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  410 bits (1053), Expect = e-113
 Identities = 485/1932 (25%), Positives = 724/1932 (37%), Gaps = 356/1932 (18%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159
            R+SC +P + +NG   +    + GS + Y C  GY L G S+ TCI+  D    W+   P
Sbjct: 1658 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716

Query: 160  ICDRIPCGLPPTITNGDFISTNR-ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
             C   PCG   T + G  +S N  +N+  G    + C       K F + G+   + TS 
Sbjct: 1717 SC-HAPCGSRSTGSEGTVLSPNYPKNYSVG----HNCVYSIAVPKEFVVFGQFVFFQTSL 1771

Query: 219  DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
             D V ++ GP  Q  + +  +  +    + +S    +      + F        KG   V
Sbjct: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKGFHFV 1826

Query: 279  KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338
              QA+ +       CS V +P          +R  + F+ G  V + C PGY L G+ ++
Sbjct: 1827 Y-QAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAI 1876

Query: 339  RC----TPQGDWSPAAPTCEVKSCDDFM----GQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
            RC         W+ + PTC +  C   +    G +L+     P +  L         EG 
Sbjct: 1877 RCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGA 1935

Query: 391  QLKGSSASYCVLAGMESL-----------------------------------WNSSVPV 415
             ++    S+      +SL                                   + S + V
Sbjct: 1936 GIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISV 1995

Query: 416  CEQIF-----------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464
                F           CP P    +G   G   + +  G  V++ CD        + L G
Sbjct: 1996 SAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCD------QGYSLQG 2046

Query: 465  ESTIRCTSDPQGNGVWSSPAPRC------------GILGHCQAPD--------------- 497
             S I C   P     W+ P P C            G++     P                
Sbjct: 2047 HSHITCMPGPVRR--WNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2104

Query: 498  -----HFLFAKLKTQT-------NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSP 545
                 H  F    T+T        +      T +     P+     FS T   +L + S 
Sbjct: 2105 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD 2164

Query: 546  KDVCKR-----------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
                K+           +SC  P    NG V +  D  VG  I++ C  G+ LIG+S+  
Sbjct: 2165 YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALT 2223

Query: 595  CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGG 651
            C L G + +W+   P C+ + CG   T  NG   S    + +      +   R  PG+G 
Sbjct: 2224 C-LHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2281

Query: 652  RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 711
               F ++    IY     D + +W GP            P +      +   S++S +  
Sbjct: 2282 YINFTVLQTEPIY-----DFITVWDGPDQ--------NSPQIGQFSGNTALESVYSTSNQ 2328

Query: 712  VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771
            +  +    F   G   +   A            RVCQPPP V +AE    D D F  G  
Sbjct: 2329 ILIKFHSDFTTSGFFVLSYHAYQ---------LRVCQPPPPVPNAEILTED-DEFEIGDI 2378

Query: 772  VFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP------ 823
            + Y C PG+ L G A + C    +     A P C+V    + +     G +L P      
Sbjct: 2379 IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSY 2438

Query: 824  VNLQLGAKVDFVCDEGFQL-------------------KGSSASYCVLAGMESLWNSSVP 864
             NLQ+ A      ++G+ +                    G +    VL  +   ++S+  
Sbjct: 2439 PNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2497

Query: 865  VCEQ-------------------------IFCPSPPVIPNG---RHTGKPLEVFPFGKTV 896
            +                             +C +P   P+G     TG  L        V
Sbjct: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL-----NSVV 2552

Query: 897  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 956
             + C    DRG  F L+G+S+  C     G   W +P P C  +  C  P        K 
Sbjct: 2553 RWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KA 2597

Query: 957  QTN----ASDFPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTP 1007
             TN     +D+ +GT + Y C   Y      +T   C  +  WS+      C   +C + 
Sbjct: 2598 PTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSI 2657

Query: 1008 PDPV--NGMVHVI--TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063
               +  +G   ++  +  +  +++ +SC  G+  +G +S EC+ +G  + W  + P CQ 
Sbjct: 2658 NSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQI 2716

Query: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
            I CG  PT  NG+ I T      YGS   + C+ G      F LVG     C S+    G
Sbjct: 2717 ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRECLSS----G 2763

Query: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183
            +WS    +C+  +   P  + NG ++ +N   +   + V ++C PGF + G     CQ  
Sbjct: 2764 LWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIGSSVRICQQD 2820

Query: 1184 NKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 1242
            + W  +LPSC  V C  P   ++  RT  +  NF+    V +SC  GY ++G    +C  
Sbjct: 2821 HNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQGPTKAQCQA 2877

Query: 1243 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEGFQLKGSSASY 1299
               WS   P C+V +C D  G   N +    +   N   G  V + C+ G+ L GSS   
Sbjct: 2878 NRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936

Query: 1300 CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTS 1359
            C   G    W+  +P C  I C  P V PN   +G   E + FG  V+Y+C         
Sbjct: 2937 CQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCT------GK 2984

Query: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKLKTQTNASDFP 1414
              L+G+S+  C    Q NG WS   P C     G  G    P H            S+F 
Sbjct: 2985 RSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH-------GSRQESNFR 3033

Query: 1415 IGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQ 1472
              ++++Y C   Y  +G     TCL N  W+  +  CK   C  P    NG V  I    
Sbjct: 3034 TKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT 3092

Query: 1473 VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNR 1532
              S + YSC  G+ L G S  +C  +G    WS   P C  I CG P   ANG       
Sbjct: 3093 FSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANG---LRYG 3146

Query: 1533 ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1592
            +++  G  V+Y C  G       EL G     CT N    G WSG  P C      TPP 
Sbjct: 3147 DDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQ 3198

Query: 1593 VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVCQPPP 1651
            + NG L   N   F     + + C PG+ +  P  + C     W  E+P C  + C  P 
Sbjct: 3199 ISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3255

Query: 1652 EILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC---AVKSC 1708
                G+       +F    EV +SC   + L G+++  C   G WS  +P C      SC
Sbjct: 3256 IPAQGKR---EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3312

Query: 1709 DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEH 1768
            ++  G   HG        Q+G+ V F C +G  L+GS+   C+       W+   P C  
Sbjct: 3313 EN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIP 3368

Query: 1769 IFCPNPPAILNGRHTGTPSGDIP-YGKEISYTCDPHPDRGMTFNLIGESTIR-CTSDPHG 1826
              C  P       H      D+P +G  + YTC P       F L G +  R C SD   
Sbjct: 3369 HSCKQPE---TPAHANVVGMDLPSHGYTLIYTCQP------GFFLAGGTEHRVCRSD--- 3416

Query: 1827 NGVWSSPAPRCE 1838
               W+   P CE
Sbjct: 3417 -NTWTGKVPICE 3427



 Score =  338 bits (866), Expect = 5e-92
 Identities = 289/974 (29%), Positives = 406/974 (41%), Gaps = 103/974 (10%)

Query: 1267 NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 1325
            +G ++     QL + V + CD GF+L G S++ C  +      W++ VP C+ I C  P 
Sbjct: 2537 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2596

Query: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 1383
               NG   G     +  G  V Y C+    R +S +L   +T  C SD    G WS+   
Sbjct: 2597 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2645

Query: 1384 APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 1441
             PRC ++  C + + F+    + +  N S +   T + + C P Y+G  P SI CL N  
Sbjct: 2646 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704

Query: 1442 WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1499
            WS  + +  C+  SC   P P NG   + T    GS   ++C  G  L+G +  EC+ SG
Sbjct: 2705 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2763

Query: 1500 NTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVG 1559
                WS     C    CG+P  I NG  I    EN+ Y   V Y+CN G      F L+G
Sbjct: 2764 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2811

Query: 1560 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1619
                 C  + +    WSG  P C+ P  C  P   + I    + + F+ N+VV F C  G
Sbjct: 2812 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2864

Query: 1620 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPS--HQDNFSPGQEVFYSCE 1677
            ++M+GP + +CQA  +W    P C  V    P I       S     NF+ G  VFY C 
Sbjct: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924

Query: 1678 PGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCD 1737
            PGY L G++ L C P G W    P C +  C      +P   VL       G+ V + C 
Sbjct: 2925 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 2982

Query: 1738 EGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI---FCPNPPAILNGRHTGTPSGDIPYGK 1794
                L G S   C L G    W+ S P C       C +P       H      +     
Sbjct: 2983 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKS 3036

Query: 1795 EISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPF 1854
             + Y CD        + L G     C +    NG W+   P C+ +V+ G+  T      
Sbjct: 3037 TVRYACD------TGYILHGSEERTCLA----NGSWTGRQPECK-AVQCGNPGTTAN--- 3082

Query: 1855 ASPTIPINDFEFPVGTSLNYECRPGYFGKMFSI-SCLENLVWSSVEDNCRRKSCGPPPEP 1913
                  I+   F   +S+ Y C  GY     S+  C  N  WS    NC   SCG P  P
Sbjct: 3083 -GKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIP 3139

Query: 1914 FNGMVHINTDTQFGSTVNYSCNEGF--RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP 1971
             NG+     D   G  V+Y C  G+   L GS   TC ++G   TW    P C  ++C  
Sbjct: 3140 ANGL-RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING---TWSGVMPTCRAVTCPT 3195

Query: 1972 PPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP 2031
            PP ISNG       T+F  G  ++Y C  G      +EL     + C       G WS  
Sbjct: 3196 PPQISNGRL---EGTNFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGE 3242

Query: 2032 PPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
             P+C+    C  P +    +  G +SF   +E + F C   F++VGS T  CQ +G W  
Sbjct: 3243 VPQCL-PKFCGDPGIPAQGKREG-KSFIYQSE-VSFSCNFPFILVGSSTRICQADGTWSG 3299

Query: 2092 KLPHC----SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQG 2147
              PHC       C+ P    HG    ++   F  G  V + C+  + L+G+ +  C P  
Sbjct: 3300 SSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL 3357

Query: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL-QLGAKVSFVCDEGFRLKGRSASHCVLA 2206
             WS   P C   SC     + P    ++ ++L   G  + + C  GF L G    H V  
Sbjct: 3358 TWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAG-GTEHRVCR 3414

Query: 2207 GMKALWNSSVPVCE 2220
                 W   VP+CE
Sbjct: 3415 SDNT-WTGKVPICE 3427



 Score =  334 bits (856), Expect = 7e-91
 Identities = 296/1001 (29%), Positives = 414/1001 (41%), Gaps = 122/1001 (12%)

Query: 817  NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 875
            +G ++     QL + V + CD GF+L G S++ C  +      W++ VP C+ I C  P 
Sbjct: 2537 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2596

Query: 876  VIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 933
               NG   G     +  G  V Y C+    R +S +L   +T  C SD    G WS+   
Sbjct: 2597 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2645

Query: 934  APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 991
             PRC ++  C + + F+    + +  N S +   T + + C P Y+G  P SI CL N  
Sbjct: 2646 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704

Query: 992  WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1049
            WS  + +  C+  SC   P P NG   + T    GS   ++C  G  L+G +  EC+ SG
Sbjct: 2705 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2763

Query: 1050 NAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109
                WS     C    CG+P  I NG  I    EN+ Y   V Y+CNPG      F L+G
Sbjct: 2764 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2811

Query: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169
                 C  + +    WSG  P C+ P  C  P   + I    + + F+ N+VV F C  G
Sbjct: 2812 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2864

Query: 1170 FVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCE 1227
            ++M+GP + +CQA  +W    P C  V C  P    +++R  + +  NF+ G  VFY C 
Sbjct: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924

Query: 1228 PGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCD 1287
            PGY L G++ + C P G W    P C +  C      +    VL       G+ V + C 
Sbjct: 2925 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 2982

Query: 1288 EGFQLKGSSASYCVLAGMESLWNSSVPVC--EQIFCPSPPVIPNGRHTGKPLEVFPFGKA 1345
                L G S+  C L G    W+ S P C  +       P  P   H  +    F     
Sbjct: 2983 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG--HGSRQESNFRTKST 3037

Query: 1346 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 1405
            V Y CD      T + L G     C +    NG W+   P C  +  C  P         
Sbjct: 3038 VRYACD------TGYILHGSEERTCLA----NGSWTGRQPECKAV-QCGNPG-------- 3078

Query: 1406 TQTNASDFPI-----GTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPD 1459
            T  N   F I      +S+ Y C   Y    P    C  N  WS     C   SC  P  
Sbjct: 3079 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGI 3138

Query: 1460 PVNGMVHVITDIQVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSTKPPICQRIPCG 1517
            P NG+ +   D  VG  ++Y C  G+   L G     C ++G    WS   P C+ + C 
Sbjct: 3139 PANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCP 3194

Query: 1518 LPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSG 1577
             PP I+NG    T   NF +G  ++Y C+ G      +EL     + C  N    G WSG
Sbjct: 3195 TPPQISNGRLEGT---NFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSG 3241

Query: 1578 PAPQCIIPNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1635
              PQC +P  C  P    GI     R    F     V F C   F++ G     CQA   
Sbjct: 3242 EVPQC-LPKFCGDP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT 3296

Query: 1636 WEPELPSC----SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT 1691
            W    P C       C+ P    HG  + ++   F  G  V + C+ G+ L+G+ +  C 
Sbjct: 3297 WSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3354

Query: 1692 PQGDWSPEAPRCAVKSCDDFLGQLP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1750
            P   WS   P C   SC     + P H  V+       G  + + C  GF L G +    
Sbjct: 3355 PDLTWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR- 3411

Query: 1751 VLVGMRSLWNNSVPVCE---HIFCPNP-PAILNGRHTGTPS 1787
             +    + W   VP+CE    I   +P PA+      GTPS
Sbjct: 3412 -VCRSDNTWTGKVPICEAGSKILVKDPRPAL------GTPS 3445



 Score =  321 bits (823), Expect = 5e-87
 Identities = 274/992 (27%), Positives = 410/992 (41%), Gaps = 124/992 (12%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH-WSTKPPICQ 1512
            C TP  P +G +   T  Q+ S + ++C  G RL+G SSA C  S    H W    P CQ
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
             I CG+P    NG  ++T   ++  G+ VTY CN G R     EL    +  C S+    
Sbjct: 2589 AISCGIPKAPTNGGILTT---DYLVGTRVTYFCNDGYR-LSSKELT---TAVCQSD---- 2637

Query: 1573 GIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFVMKGP 1625
            G WS     P+C++    T P++ + IL        N S +     V F C PG+   GP
Sbjct: 2638 GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGP 2694

Query: 1626 RRVKC--QALNKWEPELP-----SCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1678
              ++C       W  E P     SC  +  PP     G  T       S G    ++C+ 
Sbjct: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTCDL 2747

Query: 1679 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738
            G+ L G+A   C   G WS    RC    C   + +L     +   N      V + C+ 
Sbjct: 2748 GFMLVGSAVRECLSSGLWSESETRCLAGHCG--IPELIVNGQVIGENYGYRDTVVYQCNP 2805

Query: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
            GFRL GSSV  C        W+  +P C  + C +P + + GR +G       +   +++
Sbjct: 2806 GFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTF 2859

Query: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1858
            +C+      + + + G +  +C      N  WS P P C++     +C  P     +   
Sbjct: 2860 SCN------IGYLMQGPTKAQC----QANRQWSHPPPMCKVV----NCSDPGIPANSKRE 2905

Query: 1859 IPINDFEFPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFN 1915
              I    F  GT + Y+C PGYF  +F  S   C  N  W      C    CG P  P N
Sbjct: 2906 SKIEHGNFTYGTVVFYDCNPGYF--LFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN 2963

Query: 1916 GMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE---IISCEPP 1972
             ++     T FGSTV+YSC     L+G  S TC ++G+   W    P C      +C  P
Sbjct: 2964 AVLSGEKYT-FGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDP 3019

Query: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032
             T  +G   S   ++F   + V Y C TG      + L G     C +     G W+   
Sbjct: 3020 GTPGHG---SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQ 3066

Query: 2033 PRCISTNKCTAPEVE---NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 2089
            P C +  +C  P         R+ G     T +  + + C  G+++ G    QC  NG W
Sbjct: 3067 PECKAV-QCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTANGTW 3121

Query: 2090 GPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY--DLRGAASLHCTPQG 2147
               LP+C+ +    P I    + L + D++  GQ V Y C+P Y  +L G+    CT  G
Sbjct: 3122 SGTLPNCTIISCGDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3179

Query: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAG 2207
             WS   P C   +C     Q+ +GR L   N   G  +S++C  G+ L   +   CV  G
Sbjct: 3180 TWSGVMPTCRAVTCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG 3237

Query: 2208 MKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 2267
                W+  VP C   FC +P     G+  G  F    Y  E+S++C+        F L+G
Sbjct: 3238 ---TWSGEVPQCLPKFCGDPGIPAQGKREGKSF---IYQSEVSFSCN------FPFILVG 3285

Query: 2268 ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYIC 2327
             S+  C    Q +G WS  +P C      +C +P   ++G     +   +  G  + + C
Sbjct: 3286 SSTRIC----QADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHC 3339

Query: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC---SFPLFMNGISKELEMKKVYHYGDYV 2384
              G+LL G     C     WS +   C   +C     P   N +  +L       +G  +
Sbjct: 3340 KKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLP-----SHGYTL 3394

Query: 2385 TLKCEDGYTLEGSPWSQ-CQADDRWDPPLAKC 2415
               C+ G+ L G    + C++D+ W   +  C
Sbjct: 3395 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426



 Score =  299 bits (766), Expect = 2e-80
 Identities = 244/822 (29%), Positives = 336/822 (40%), Gaps = 94/822 (11%)

Query: 67   TYLNYECRPGYSGR-PFSIICLKNSVWTGAKDR--CRRKSCRNPPDPVNGMVHVIKGIQF 123
            T + + C PGY G  P SI CL N  W+   +R  C+  SC   P P NG   +     +
Sbjct: 2679 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSY 2737

Query: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183
            GS   ++C  G+ L+GS+   C+ SG   +W      C    CG+P  I NG  I    E
Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQVIG---E 2791

Query: 184  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243
            N+ Y   V Y+CNPG      F L+G     C  + +    WSG  P C+ P  C  P  
Sbjct: 2792 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2839

Query: 244  ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPD 302
             + I    + + F+ N+VV F C  G++M+GP + +CQA  +W    P C  V C  P  
Sbjct: 2840 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898

Query: 303  VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
              +++R  + +  NF+ G  VFY C PGY L G++ + C P G W    P C +  C   
Sbjct: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2957

Query: 362  MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC--EQI 419
               +    VL       G+ V + C     L G S+  C L G    W+ S P C  +  
Sbjct: 2958 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3013

Query: 420  FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479
                 P  P   H  +    F    TV Y CD      T + L G     C +    NG 
Sbjct: 3014 GTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA----NGS 3061

Query: 480  WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTSLKYECRPEY-YGRPFS 533
            W+   P C  +  C  P         T  N   F I      +S+ Y C   Y    P  
Sbjct: 3062 WTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSV 3112

Query: 534  ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH--RLIGHS 591
              C  N  WS     C   SC  P  P NG+ +   D  VG  ++Y C  G+   L G  
Sbjct: 3113 RQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSR 3171

Query: 592  SAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGG 651
               C ++G    WS   P C+ + C  PP I+NG    T   NF +G  ++Y C+PG   
Sbjct: 3172 IRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYICSPG--- 3222

Query: 652  RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR--SLFSLN 709
               +EL     + C  N    G WSG  PQC +P  C  P    GI     R    F   
Sbjct: 3223 ---YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP----GIPAQGKREGKSFIYQ 3270

Query: 710  EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQPPPDVLHAERTQRDKDN 765
              V F C   F++ G     CQA   W    P C       C+ P    H   +Q +   
Sbjct: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFG 3328

Query: 766  FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN 825
            F  G  V + C+ G+ L+G+ +  C P   WS   P C   SC        +  V+    
Sbjct: 3329 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-PETPAHANVVGMDL 3387

Query: 826  LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867
               G  + + C  GF L G +     +   ++ W   VP+CE
Sbjct: 3388 PSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICE 3427



 Score =  295 bits (755), Expect = 4e-79
 Identities = 446/1993 (22%), Positives = 711/1993 (35%), Gaps = 411/1993 (20%)

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGI 697
            GS + Y CNPG      + L G   + C + + +   W  P P CI           +G 
Sbjct: 1334 GSTIIYGCNPG------YTLHGSSLLKCMTGERRA--WDYPLPSCIAECGGRFKGESSGR 1385

Query: 698  LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD----- 752
            ++S        N +   RC     +     V  Q L           RV   PP+     
Sbjct: 1386 ILSPGYPFPYDNNL---RCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLL 1442

Query: 753  --------------VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
                           L+    Q D D        FY  + G+ ++ ++S+    +    P
Sbjct: 1443 KEISGSLIPEGIHSTLNIVTIQFDTD--------FYISKSGFAIQFSSSVATACR---DP 1491

Query: 799  AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
              P    ++ D        GR       + G  V F CD G++L+G     C+       
Sbjct: 1492 GVPMNGTRNGD--------GR-------EPGDTVVFQCDPGYELQGEERITCIQVENRYF 1536

Query: 859  WNSSVPVCEQIFCPSPPVIP-NGRHTGKPLEV--------FPFGKTVNYTCDPHPDRGTS 909
            W  S PVC         + P  G  TG    +        +P  +  ++T   + D   S
Sbjct: 1537 WQPSPPVC---------IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVIS 1587

Query: 910  FDLIGESTIRCTSDPQGNG--VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGT 967
               I  S      +P  +   ++  P     ++G  Q       +KL  +  +S   +  
Sbjct: 1588 LAFISFSI-----EPNYDFLYIYDGPDSNSPLIGSFQD------SKLPERIESSSNTMHL 1636

Query: 968  SLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1027
            + + +    Y G  F +     L          R+SC  P + +NG   +  D ++GS +
Sbjct: 1637 AFRSDGSVSYTG--FHLEYKAKL----------RESCFDPGNIMNG-TRLGMDYKLGSTV 1683

Query: 1028 NYSCTTGHRLIGHSSAECILSGNAAH-WSTKPPICQRIPCGLPPTIANGDFISTNR-ENF 1085
             Y C  G+ L G+S+  CI+  +    W+   P C   PCG   T + G  +S N  +N+
Sbjct: 1684 TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNY 1742

Query: 1086 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 1145
              G    + C       K F + G+   + TS  D V ++ GP  Q  + +  +  +   
Sbjct: 1743 SVG----HNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGE 1798

Query: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 1205
             + +S    +      + F        KG   V  QA+ +       CS V +P      
Sbjct: 1799 SLPLSSGNQI-----TIRFTSVGPITAKGFHFVY-QAVPRTSST--QCSSVPEP------ 1844

Query: 1206 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC----TPQGDWSPAAPTCEVKSCDDF 1261
                +R  + F+ G  V + C PGY L G+ ++RC         W+ + PTC +  C   
Sbjct: 1845 -RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGI 1902

Query: 1262 M----GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL--------- 1308
            +    G +L+     P +  L         EG  ++    S+      +SL         
Sbjct: 1903 LTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1962

Query: 1309 --------------------------WNSSVPVCEQIF-----------CPSPPVIPNGR 1331
                                      + S + V    F           CP P    +G 
Sbjct: 1963 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGI 2022

Query: 1332 HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 1387
              G   + +  G  V++ CD        + L G S I C   P     W+ P P C    
Sbjct: 2023 KIG---DRYMVGDVVSFQCDQ------GYSLQGHSHITCMPGPVRR--WNYPIPICLAQC 2071

Query: 1388 --------GILGHCQAPD--------------------HFLFAKLKTQT-------NASD 1412
                    G++     P                     H  F    T+T        +  
Sbjct: 2072 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2131

Query: 1413 FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKR-----------KSCKTPPDPV 1461
                T +     P+     FS T   +L + S     K+           +SC  P    
Sbjct: 2132 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 2191

Query: 1462 NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPT 1521
            NG V +  D  VG  I++ C  G+ LIG+S+  C L G + +W+   P C+ + CG   T
Sbjct: 2192 NGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRCEAL-CGGNIT 2248

Query: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKV---FELVGEPSIYCTSNDDQVGIWSGP 1578
              NG   S    + +      +       G  +   F ++    IY     D + +W GP
Sbjct: 2249 AMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY-----DFITVWDGP 2303

Query: 1579 APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP 1638
                        P +      +   S++S +  +  +    F   G   +   A      
Sbjct: 2304 DQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQL--- 2352

Query: 1639 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP----QG 1694
                  RVCQPPP + + E   +  D F  G  + Y C PG+ L G A L C      Q 
Sbjct: 2353 ------RVCQPPPPVPNAEIL-TEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQM 2405

Query: 1695 DWSPEAPRCAVKSCDDFLGQLPHGRVLFP------LNLQLGAKVSFVCDEGFRLK----- 1743
            D +P  P C V    + L     G +L P       NLQ+ A  S   ++G+ +      
Sbjct: 2406 DGAP--PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAW-SISVEKGYNITMFVEF 2462

Query: 1744 --------------GSSVSHCVLVGMRSLWNNSVPVCEH--------------------- 1768
                          G ++   VL+ +   ++++  +  +                     
Sbjct: 2463 FQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRI 2522

Query: 1769 ----IFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP 1824
                 +C  P +  +G       G +     + + CD    RG  F L+G+S+  C    
Sbjct: 2523 RYIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACD----RG--FRLVGKSSAVCRKSS 2574

Query: 1825 HGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY---F 1881
            +G   W +P P C+ ++  G  K P      +        ++ VGT + Y C  GY    
Sbjct: 2575 YGYHAWDAPVPACQ-AISCGIPKAPTNGGILTT-------DYLVGTRVTYFCNDGYRLSS 2626

Query: 1882 GKMFSISCLENLVWSSVEDN--CRRKSCGPPPEPF---NGMVHI--NTDTQFGSTVNYSC 1934
             ++ +  C  +  WS+      C   +C P    F   +G   I   +  ++ + V +SC
Sbjct: 2627 KELTTAVCQSDGTWSNHNKTPRCVVVTC-PSINSFILEHGRWRIVNGSHYEYKTKVVFSC 2685

Query: 1935 NEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVV 1994
            + G+  +G  S  CL +G   +W  + P C+IISC   PT  NG+     +TS+  G+  
Sbjct: 2686 DPGYHGLGPASIECLPNGT-WSWRNERPYCQIISCGELPTPPNGNKIGT-QTSY--GSTA 2741

Query: 1995 TYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPG 2054
             + C  G      F LVG     C S     G+WS    RC++ + C  PE+    +V G
Sbjct: 2742 IFTCDLG------FMLVGSAVRECLSS----GLWSESETRCLAGH-CGIPELIVNGQVIG 2790

Query: 2055 NRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTL 2113
                +   + + ++C PGF ++GS    CQ +  W  +LP C  V C  P   ++G    
Sbjct: 2791 EN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--- 2845

Query: 2114 SHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDD--------FL 2165
            +  + F+    V +SC   Y ++G     C     WS   P C V +C D          
Sbjct: 2846 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRE 2905

Query: 2166 GQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCP 2225
             ++ HG      N   G  V + C+ G+ L G S   C   G    W+  +P C  I C 
Sbjct: 2906 SKIEHG------NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCG 2956

Query: 2226 NPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS 2285
            +P    N   +G  +    +G  + Y+C          +L+G+SS  C    Q NG WS 
Sbjct: 2957 HPGVPPNAVLSGEKY---TFGSTVHYSCTGKR------SLLGQSSRTC----QLNGHWSG 3003

Query: 2286 PAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 2345
              P C       C  P    +G       S +    T+ Y CD GY+L G     C   G
Sbjct: 3004 SQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 3060

Query: 2346 IWSQLDHYCKEVNCSFPLFMNGISKELEMKKV--YHYGDYVTLKCEDGYTLEGSPWSQCQ 2403
             W+     CK V C  P    G +   ++ ++    +   V   C +GY L G    QC 
Sbjct: 3061 SWTGRQPECKAVQCGNP----GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3116

Query: 2404 ADDRWDPPLAKCT 2416
            A+  W   L  CT
Sbjct: 3117 ANGTWSGTLPNCT 3129



 Score =  273 bits (698), Expect = 2e-72
 Identities = 269/980 (27%), Positives = 386/980 (39%), Gaps = 167/980 (17%)

Query: 43   CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTGAK 96
            C+ PE  P     + T      + + + + C  G+   G+  S +C K+S     W    
Sbjct: 2529 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2584

Query: 97   DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD- 155
              C+  SC  P  P NG + +      G+++ Y C  GYRL      T +   D   W  
Sbjct: 2585 PACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSN 2642

Query: 156  -NETPICDRIPCGLPPTIT-----NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 209
             N+TP C  + C   P+I      +G +   N  ++ Y + V + C+PG  G      +G
Sbjct: 2643 HNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LG 2693

Query: 210  EPSIYCTSNDDQVGIWSGPAPQCIIPNKC----TPPN-----------------VENGIL 248
              SI C  N      W    P C I + C    TPPN                  + G +
Sbjct: 2694 PASIECLPNG--TWSWRNERPYCQIIS-CGELPTPPNGNKIGTQTSYGSTAIFTCDLGFM 2750

Query: 249  V----------------SDNRSL-------------------FSLNEVVEFRCQPGFVMK 273
            +                S+ R L                   +   + V ++C PGF + 
Sbjct: 2751 LVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLI 2810

Query: 274  GPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 332
            G     CQ  + W  +LPSC  V C  P   ++  RT  +  NF+    V +SC  GY +
Sbjct: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLM 2867

Query: 333  RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEG 389
            +G    +C     WS   P C+V +C D  G   N +    +   N   G  V + C+ G
Sbjct: 2868 QGPTKAQCQANRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPG 2926

Query: 390  FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYT 449
            + L GSS   C   G    W+  +P C  I C  P V PN   +G   E + FG TV+Y+
Sbjct: 2927 YFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYS 2980

Query: 450  CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKL 504
            C           L+G+S+  C    Q NG WS   P C     G  G    P H      
Sbjct: 2981 CT------GKRSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH------ 3024

Query: 505  KTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
                  S+F   ++++Y C   Y  +G     TCL N  W+  +  CK   C  P    N
Sbjct: 3025 -GSRQESNFRTKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTAN 3082

Query: 563  GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTI 622
            G V  I      S + YSC  G+ L G S  +C  +G    WS   P C  I CG P   
Sbjct: 3083 GKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIP 3139

Query: 623  ANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 682
            ANG       +++  G  V+Y C PG       EL G     CT N    G WSG  P C
Sbjct: 3140 ANG---LRYGDDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTC 3188

Query: 683  IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 742
                  TPP + NG L   N   F     + + C PG+ +  P  + C     W  E+P 
Sbjct: 3189 RAVTCPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3245

Query: 743  C-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAP 801
            C  + C  P       + +R+  +F    EV +SC   + L G+++  C   G WS ++P
Sbjct: 3246 CLPKFCGDPG---IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3302

Query: 802  TC---EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
             C      SC++  G   +G        Q+G+ V F C +G  L+GS+   C+    +  
Sbjct: 3303 HCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLT 3358

Query: 859  WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
            W+   P C    C  P    +    G  +++   G T+ YTC P       F L G +  
Sbjct: 3359 WSGIQPECIPHSCKQPETPAHANVVG--MDLPSHGYTLIYTCQP------GFFLAGGTEH 3410

Query: 919  R-CTSDPQGNGVWSSPAPRC 937
            R C SD      W+   P C
Sbjct: 3411 RVCRSD----NTWTGKVPIC 3426



 Score =  220 bits (561), Expect = 1e-56
 Identities = 167/559 (29%), Positives = 241/559 (43%), Gaps = 53/559 (9%)

Query: 63   FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGI 121
            F  GT + Y+C PGY     S+ IC  N  W      C    C +P  P N ++   K  
Sbjct: 2913 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-Y 2971

Query: 122  QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD---RIPCGLPPTITNGDFI 178
             FGS + YSCT    L+G SS TC ++G    W    P C       CG P T  +G   
Sbjct: 2972 TFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG--- 3025

Query: 179  STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 238
            S    NF   S V Y C+ G      + L G     C +N    G W+G  P+C      
Sbjct: 3026 SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAVQCG 3075

Query: 239  TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
             P    NG +   + + FS +  V + C  G+++ GP   +C A   W   LP+C+ +  
Sbjct: 3076 NPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3133

Query: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY--DLRGAASMRCTPQGDWSPAAPTCEVK 356
              P +       R  D++  GQ V Y C+PGY  +L G+    CT  G WS   PTC   
Sbjct: 3134 GDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3191

Query: 357  SCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 416
            +C     Q+ NGR L   N   G  + ++C  G++L   +   CV  G    W+  VP C
Sbjct: 3192 TCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG---TWSGEVPQC 3246

Query: 417  EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 476
               FC  P +   G+  GK    F +   V+++C+        F L+G ST  C    Q 
Sbjct: 3247 LPKFCGDPGIPAQGKREGKS---FIYQSEVSFSCN------FPFILVGSSTRIC----QA 3293

Query: 477  NGVWSSPAPRC--GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSI 534
            +G WS  +P C       C+ P      +  +Q N   F +G+ +++ C+  +  +  + 
Sbjct: 3294 DGTWSGSSPHCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTT 3350

Query: 535  -TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSA 593
             TCL +L WS  +  C   SCK P  P +  V  +     G  + Y+C  G  L G +  
Sbjct: 3351 RTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEH 3410

Query: 594  ECILSGNAAHWSTKPPICQ 612
                S N   W+ K PIC+
Sbjct: 3411 RVCRSDNT--WTGKVPICE 3427



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 99/409 (24%)

Query: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965
            C  P EP NG   I +D   GSTV +SC+E + L G+ S TC  ++     W    P+C+
Sbjct: 446  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 1966 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 2000
            + +C      P  T ++ +F   Y +N       T+ +   V+            Y   T
Sbjct: 505  VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564

Query: 2001 GPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTN--------KCTAPEVEN-AI 2050
              DG ++ +      +   S   D +   SS     + T+        K    E+E  + 
Sbjct: 565  IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624

Query: 2051 RVPGNRSF-------FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-----SR 2098
              PG   +       F+  +++RF CQ GF ++G  ++ CQ N +W   +P C     S 
Sbjct: 625  GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 684

Query: 2099 VCQPPPEILHGEHTLSHQDNFS--------PGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
               P   +L  ++   + +N +        PG  +  S    +DL           GD S
Sbjct: 685  FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-S 742

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPL--------------------------------- 2177
            PE+P     +  +    L     +L L                                 
Sbjct: 743  PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPIN 802

Query: 2178 ------NLQLGAKVSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVC 2219
                  N QLG+ +S +C+EGF + +G     C+L   K +W+  +P C
Sbjct: 803  ARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 225/1043 (21%), Positives = 355/1043 (34%), Gaps = 219/1043 (20%)

Query: 183  ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP- 241
            +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+C  P  C    
Sbjct: 808  DNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPKCGAP--CGGHF 859

Query: 242  NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
            +  +G+++S     +   SLN       +PG  +K           +++ EL        
Sbjct: 860  SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQTELNYDVLEVH 912

Query: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358
              P++L         +     Q +F S    Y L    + R          + T    SC
Sbjct: 913  DGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970

Query: 359  DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418
             D  G  ++GR  +  +  +G+ V F CD G++L       C        W+  +P C+ 
Sbjct: 971  LD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1025

Query: 419  IFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD-------------LI 463
            + C      P+G     G P E +P      +T D    +G  F+             LI
Sbjct: 1026 L-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1083

Query: 464  GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
             E+        +  G    P    G+ G+ +A   F+          SDF    S+ YE 
Sbjct: 1084 TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SDF----SISYE- 1128

Query: 524  RPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCT 582
                    F+IT  + NL           + C+ P  P  G   +  +  +G  + +SC+
Sbjct: 1129 -------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNFGIGDTLTFSCS 1169

Query: 583  TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR----ENFHYG 638
            +G+RL G S   C L G    WS   P C    CG   T   G  +S N     EN H  
Sbjct: 1170 SGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHE- 1226

Query: 639  SVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695
             + + +   G G     + F L         +  D + I+ G      +    T  ++  
Sbjct: 1227 CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277

Query: 696  GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
              L S +  L+     +EF        +G + V          EL  C       P +  
Sbjct: 1278 LTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE-----DPGIPQ 1321

Query: 756  AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMG 813
                  D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+C  +    F G
Sbjct: 1322 FGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1380

Query: 814  QLLNGRVL-----FPVNLQLGAKVDFVCDEG------FQLKGSSASYCVLAGMESLWNSS 862
            +  +GR+L     FP +  L        D G      F    + AS+ +L     +W+  
Sbjct: 1381 E-SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDIL----RVWDGP 1435

Query: 863  VPVCEQIFCPSPPVIPNGRHTGKPLEVFPF------------------------------ 892
                  +   S  +IP G H+   +    F                              
Sbjct: 1436 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495

Query: 893  -----------GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 937
                       G TV + CDP       ++L GE  I C    +    W    P C    
Sbjct: 1496 NGTRNGDGREPGDTVVFQCDP------GYELQGEERITCI-QVENRYFWQPSPPVCIAPC 1548

Query: 938  -----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW 992
                 G  G   +P+   F      +   D+ I  +  Y     +    FSI    + ++
Sbjct: 1549 GGNLTGSSGFILSPN---FPHPYPHSRDCDWTITVNADYVISLAFIS--FSIEPNYDFLY 1603

Query: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052
                           PD  + ++    D ++  RI  S  T H L   S      +G   
Sbjct: 1604 -----------IYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTGFHL 1651

Query: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112
             +  K     R  C  P  I NG  +     ++  GS VTY C+ G      + L G  +
Sbjct: 1652 EYKAK----LRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYST 1698

Query: 1113 IYCTSNDDQVGIWSGPAPQCIIP 1135
            + C   DD    W+   P C  P
Sbjct: 1699 LTCIMGDDGRPGWNRALPSCHAP 1721



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 196/861 (22%), Positives = 310/861 (36%), Gaps = 172/861 (19%)

Query: 460  FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 519
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 654  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 693

Query: 520  KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 564
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 694  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 749

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPC-GLPPTIA 623
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 750  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 800

Query: 624  NGDFISTNR--ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 801  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 850

Query: 682  CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 737
            C  P  C    +  +G+++S     +   SLN       +PG  +K           +++
Sbjct: 851  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQ 901

Query: 738  PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
             EL          P++L         +     Q +F S    Y L    + R        
Sbjct: 902  TELNYDVLEVHDGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 959

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 857
              + T    SC D  G  ++GR  +  +  +G+ V F CD G++L       C       
Sbjct: 960  YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNH 1014

Query: 858  LWNSSVPVCEQIFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD---- 911
             W+  +P C+ + C      P+G     G P E +P      +T D    +G  F+    
Sbjct: 1015 WWSHPLPTCDAL-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTF 1072

Query: 912  ---------LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD 962
                     LI E+        +  G    P    G+ G+ +A   F+          SD
Sbjct: 1073 HLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SD 1122

Query: 963  FPIGTSLKYECRPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDI 1021
            F    S+ YE         F+IT  + NL           + C+ P  P  G   +  + 
Sbjct: 1123 F----SISYE--------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNF 1158

Query: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081
             +G  + +SC++G+RL G S   C L G    WS   P C    CG   T   G  +S N
Sbjct: 1159 GIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPN 1216

Query: 1082 R----ENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 1134
                 EN H   + + +   G G     + F L         +  D + I+ G      +
Sbjct: 1217 YPLNYENNHE-CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHL 1266

Query: 1135 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1194
                T  ++    L S +  L+     +EF        +G + V          EL  C 
Sbjct: 1267 LGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE 1315

Query: 1195 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPT 1252
                  P +        D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+
Sbjct: 1316 -----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPS 1369

Query: 1253 CEVKSCDDFMGQLLNGRVLFP 1273
            C  +    F G+  +GR+L P
Sbjct: 1370 CIAECGGRFKGE-SSGRILSP 1389



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 134/603 (22%), Positives = 207/603 (34%), Gaps = 149/603 (24%)

Query: 1606 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPEILHGEHTP 1660
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   +L  ++  
Sbjct: 640  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699

Query: 1661 SHQDNFS--------PGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP----------- 1701
             + +N +        PG  +  S    +DL           GD SPE+P           
Sbjct: 700  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757

Query: 1702 ----------RCAVKSCDDFLGQ------------------LPHGRVLFPLNLQLGAKVS 1733
                      R   ++     G+                  +P     F  N QLG+ +S
Sbjct: 758  SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSIS 817

Query: 1734 FVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI-- 1790
             +C+EGF + +G+    C+L+  + +W+  +P C        P    G H   PSG I  
Sbjct: 818  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC------GAPC---GGHFSAPSGVILS 868

Query: 1791 ---PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSV 1841
               P   + S  C      +P     +TF            + H      SP     L  
Sbjct: 869  PGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP-----LLG 923

Query: 1842 RAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1901
                 + P QF F+S     ++F + + T+ N     G+            + + SV  N
Sbjct: 924  SYNGTQVP-QFLFSS-----SNFIYLLFTTDNSRSNNGF-----------KIHYESVTVN 966

Query: 1902 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961
                SC  P  P +G      D   GSTV++SC+ G+RL       C     N  W    
Sbjct: 967  --TYSCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPL 1020

Query: 1962 PICEIIS----CEPPPTISN---GDFYSNN-----RTSFHNGTVVTYQCHT-GPDGEQLF 2008
            P C+ +       P  TI +    +FY N+          +G  V +  HT   +    +
Sbjct: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080

Query: 2009 ELVGERSIYCTSKDDQVGVWSSPPP--------------RCISTNKCT------------ 2042
             L+ E   +        G  S  PP              R IS    +            
Sbjct: 1081 LLITENGSFTQPLARLTG--SDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138

Query: 2043 -APEVENAIRVPGNRSFFT--LTEIIRFRCQPGFVMVGSHTVQCQTNGR--WGPKLPHCS 2097
              P  +  I   G+R  F   + + + F C  G+ + G+  + C   GR  W   LP C 
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198

Query: 2098 RVC 2100
              C
Sbjct: 1199 AEC 1201



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 203/866 (23%), Positives = 304/866 (35%), Gaps = 179/866 (20%)

Query: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 1419
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 654  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 693

Query: 1420 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 1464
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 694  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 749

Query: 1465 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC-GLPPTIA 1523
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 750  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 800

Query: 1524 NGDFISTNR--ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 801  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 850

Query: 1582 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1637
            C  P  C    +  +G+++S     +   SLN       +PG  +K         LN   
Sbjct: 851  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 908

Query: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697
             E+     +  P     +G   P    + S    + ++ +      G   +H        
Sbjct: 909  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGF-KIHY------- 960

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS 1757
             E+      SC D  G   HGR  +  +  +G+ VSF CD G+RL   S    +L     
Sbjct: 961  -ESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014

Query: 1758 LWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI---------PYGKEISYTCDPHPDRGM 1808
             W++ +P C+        A+  G   G PSG I         P     ++T D    +G+
Sbjct: 1015 WWSHPLPTCD--------ALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065

Query: 1809 TFNLIGESTIRCTSDPHG------NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1862
             FN     T     D H       NG ++ P  R   S             F +    I+
Sbjct: 1066 QFNF---HTFHL-EDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFIS 1121

Query: 1863 DFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922
            DF      S++YE     F   FS   LE               C  P  P  G   I  
Sbjct: 1122 DF------SISYEG----FNITFSEYNLE--------------PCEDPGIPQYGS-RIGF 1156

Query: 1923 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS 1982
            +   G T+ +SC+ G+RL G+    CL  G  V W    P C +  C    T + G   S
Sbjct: 1157 NFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-VAECGASATNNEGILLS 1214

Query: 1983 -NNRTSFHNGTVVTY--QCHTGPD---GEQLFELV-GERSIYCTSKDDQ---VGVWSSPP 2032
             N   ++ N     Y  Q   G       + F L  G+       KD     +G ++   
Sbjct: 1215 PNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGAS 1274

Query: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPK 2092
             R +     T     N + +  N       E        GF +V +             +
Sbjct: 1275 MRGL-----TLSSTSNQLWLEFNSDTEGTDE--------GFQLVYTSF-----------E 1310

Query: 2093 LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT--PQGDWS 2150
            L HC       P I    + +S Q +F+ G  + Y C P Y L G++ L C    +  W 
Sbjct: 1311 LSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWD 1364

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLP 2176
               P C  +    F G+   GR+L P
Sbjct: 1365 YPLPSCIAECGGRFKGE-SSGRILSP 1389



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 107/455 (23%), Positives = 163/455 (35%), Gaps = 100/455 (21%)

Query: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVIWDNETPICD 162
           C +P +P NG   +      GS +++SC + Y L G+ S TC  I+     W +  P+C 
Sbjct: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 163 RIPC-----GLPPTITNGDF----------------ISTNRE---NFH-YGSVVTY-RCN 196
              C     G   T T+ +F                ++TN+    NF  +   + Y    
Sbjct: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564

Query: 197 PGSGG-----RKVFE-LVGE--PSIYCTSN---------DDQVG-IWSGPAPQCIIPNKC 238
            G GG     R V + L G   P +  + +         D+ VG +      + I    C
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624

Query: 239 TPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---- 293
             P     GI   D    FS  +V+ F CQ GF + G + + CQ  N+W   +P C    
Sbjct: 625 GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681

Query: 294 -SRVCQPPPDVLHAERTQRDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQG 344
            S    P   VL  +  +   +N +        PG  +  S    +DL           G
Sbjct: 682 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 740

Query: 345 DWSPAAPTCEVKSCDDFMGQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403
           D SP +P     +  +    L  N  +L         +++F  D     +G + +Y    
Sbjct: 741 D-SPESPILGTFTGAEVPSHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFG 790

Query: 404 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
             E              CP P +  N R  G   + F  G +++  C+            
Sbjct: 791 HNE--------------CPDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQ 828

Query: 464 GESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAP 496
           G  TI C     G  +WS   P+CG    GH  AP
Sbjct: 829 GTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 862



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 137/619 (22%), Positives = 201/619 (32%), Gaps = 134/619 (21%)

Query: 384  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 442
            F C  GF+L G  +  C      + W++++P+C  IF C S    P G         +P 
Sbjct: 648  FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 699

Query: 443  GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
            G   N  C      DP      SF D   ES     +   G+   S  +P  G     + 
Sbjct: 700  GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 756

Query: 496  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 555
            P H         T+ S       L+++      GR F+IT           +      C 
Sbjct: 757  PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 795

Query: 556  TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 614
             P  P+N       + Q+GS I+  C  G  +  G  +  CIL      WS   P C   
Sbjct: 796  DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 853

Query: 615  PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
            PCG   +  +G  +S     ++  S+         PG   +  FE           N D 
Sbjct: 854  PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 908

Query: 672  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731
            + +  GP     +        V    L S +  ++ L      R   GF +      +  
Sbjct: 909  LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 963

Query: 732  ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791
             +N +          C  P   +H  R   D   FS G  V +SC+ GY L     + C 
Sbjct: 964  TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1011

Query: 792  PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 841
                WS   PTC+     D  G   +G +L       +P +L     VD    +G Q   
Sbjct: 1012 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1069

Query: 842  --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 870
                                      L GS     + AG+   + + +            
Sbjct: 1070 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1129

Query: 871  ------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
                        C  P +   G   G     F  G T+ ++C       + + L G S I
Sbjct: 1130 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1180

Query: 919  RCTSDPQGNGVWSSPAPRC 937
             C     G  VWS+P PRC
Sbjct: 1181 ICLGG--GRRVWSAPLPRC 1197



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 143/626 (22%), Positives = 213/626 (34%), Gaps = 125/626 (19%)

Query: 553  SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 611
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S N A W    PIC
Sbjct: 137  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195

Query: 612  Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 667
            +    CG     ++G   S +  N +H  +  T+     PG     +F            
Sbjct: 196  RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 250

Query: 668  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE-------FRCQPGF 720
              D + I     P   +     PP       +  N++   L+ V +       F      
Sbjct: 251  KYDYLEIEGSEPPTIWLSGMNIPPP------IISNKNWLRLHFVTDSNHRYRGFSAPYQG 304

Query: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780
                        L +          V   P DV  +  T       S  Q V  +     
Sbjct: 305  SSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVT----- 359

Query: 781  DLRGAASMRCTPQGDWSP-AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEG 839
             LR +     T +   SP  A T   +       Q+   + L  V  ++   +DF    G
Sbjct: 360  SLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFK-SRG 418

Query: 840  FQL---KGSSASYCVL--AGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 894
            F+L   K +S  + +L   G+++  N          CP P    NG+  G     F  G 
Sbjct: 419  FKLFPGKDNSNKFSILNEGGIKTASN---------LCPDPGEPENGKRIGSD---FSLGS 466

Query: 895  TVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL---GHCQAPDHFLF 951
            TV ++CD        + L G  +I C    +    WS   P C +     + Q P     
Sbjct: 467  TVQFSCD------EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 520

Query: 952  A---KLKTQTNASDFPIGTSLKYECRPEYYGRPF-------SITCLDNLVWSSPKDVCKR 1001
            +     +  +NA    + T++      +     F       ++T  D      P+ V + 
Sbjct: 521  SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQV 580

Query: 1002 KSCKTPPDPVNGM-----VHVITDIQVGS---RINYSCTTGHRLIGHSSAECILSGNAAH 1053
             +    PD +  M     +H+ TD  VGS   ++NY                        
Sbjct: 581  LTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK----------------------- 617

Query: 1054 WSTKPPICQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109
                    ++  CG P T    I  GD  S NR+      V+ + C  G      FEL+G
Sbjct: 618  ------EIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIG 658

Query: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIP 1135
            E SI C  N+     WS   P CI P
Sbjct: 659  EKSIVCQENNQ----WSANIPICIFP 680



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 136/619 (21%), Positives = 200/619 (32%), Gaps = 134/619 (21%)

Query: 834  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 892
            F C  GF+L G  +  C      + W++++P+C  IF C S    P G         +P 
Sbjct: 648  FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 699

Query: 893  GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
            G   N  C      DP      SF D   ES     +   G+   S  +P  G     + 
Sbjct: 700  GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 756

Query: 946  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 1005
            P H         T+ S       L+++      GR F+IT           +      C 
Sbjct: 757  PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 795

Query: 1006 TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 1064
             P  P+N       + Q+GS I+  C  G  +  G  +  CIL      WS   P C   
Sbjct: 796  DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 853

Query: 1065 PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
            PCG   +  +G  +S     ++  S+         PG   +  FE           N D 
Sbjct: 854  PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 908

Query: 1122 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 1181
            + +  GP     +        V    L S +  ++ L      R   GF +      +  
Sbjct: 909  LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 963

Query: 1182 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 1241
             +N +          C  P   +H  R   D   FS G  V +SC+ GY L     + C 
Sbjct: 964  TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1011

Query: 1242 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 1291
                WS   PTC+     D  G   +G +L       +P +L     VD    +G Q   
Sbjct: 1012 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1069

Query: 1292 --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 1320
                                      L GS     + AG+   + + +            
Sbjct: 1070 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1129

Query: 1321 ------------CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTI 1368
                        C  P +   G   G     F  G  + ++C       + + L G S I
Sbjct: 1130 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1180

Query: 1369 RCTSDPQGNGVWSSPAPRC 1387
             C     G  VWS+P PRC
Sbjct: 1181 ICLGG--GRRVWSAPLPRC 1197



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 132/647 (20%), Positives = 223/647 (34%), Gaps = 127/647 (19%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G     +G   GS I Y C  GY L GSS   C+ +G+   WD   P C  
Sbjct: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIA 1372

Query: 164  IPCGLPPTITNGDFISTNRENFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTS 217
               G     ++G  +S     F Y +    RC      +PG+     F      +    +
Sbjct: 1373 ECGGRFKGESSGRILSPGYP-FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEA 1424

Query: 218  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
            + D + +W GP    ++  + +   +  GI  + N  + ++    +F     ++ K    
Sbjct: 1425 SHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFA 1477

Query: 278  VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS 337
            ++  +         S +  C+ P   ++  R   + D   PG  V + C+PGY+L+G   
Sbjct: 1478 IQFSS---------SVATACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEER 1525

Query: 338  MRCTPQGD---WSPAAPTCEVKSCDDFMGQLLNGRVLFP--------------------- 373
            + C    +   W P+ P C      +  G   +G +L P                     
Sbjct: 1526 ITCIQVENRYFWQPSPPVCIAPCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNAD 1583

Query: 374  -------VNLQLGAKVDFVC-----DEGFQLKGSSASYCVLAGMESLWNS---------- 411
                   ++  +    DF+      D    L GS     +   +ES  N+          
Sbjct: 1584 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1643

Query: 412  ----------SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
                         + E  F P    I NG   G     +  G TV Y CD        + 
Sbjct: 1644 VSYTGFHLEYKAKLRESCFDPGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYV 1692

Query: 462  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            L G ST+ C     G   W+   P       C AP        +    + ++P   S+ +
Sbjct: 1693 LQGYSTLTCIMGDDGRPGWNRALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGH 1746

Query: 522  ECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
             C       P         V+  +S  DV +       P   + ++  ++    G  +  
Sbjct: 1747 NC-VYSIAVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPL 1802

Query: 580  SCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYG 638
            S  +G+++    ++   ++    H+  +  P      C   P    G  I      F  G
Sbjct: 1803 S--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVG 1857

Query: 639  SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            S V + CNPG      + L G  +I C +  + +  W+   P CI+P
Sbjct: 1858 SSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 104/479 (21%), Positives = 156/479 (32%), Gaps = 110/479 (22%)

Query: 69   LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128
            L ++     SGR F+I            +      C +P  P+N         Q GS I 
Sbjct: 769  LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINAR-RFGDNFQLGSSIS 817

Query: 129  YSCTKGY-RLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHY 187
              C +G+ +  G+ + TCI+    V+W    P C   PCG   +  +G  +S     ++ 
Sbjct: 818  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG-APCGGHFSAPSGVILSPGWPGYYK 876

Query: 188  GSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP---APQCIIPNKCTPP 241
             S+         PG   +  FE           N D + +  GP   +P     N    P
Sbjct: 877  DSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVP 931

Query: 242  NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
                  L S +  ++ L      R   GF +      +   +N +          C  P 
Sbjct: 932  Q----FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 974

Query: 302  DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
              +H  R   D   FS G  V +SC+ GY L     + C     WS   PTC+     D 
Sbjct: 975  IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1031

Query: 362  MGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ----------------------- 391
             G   +G +L       +P +L     VD    +G Q                       
Sbjct: 1032 RGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089

Query: 392  ------LKGSSASYCVLAGMESLWNSSVPVCEQIF-----------------CPSPPVIP 428
                  L GS     + AG+   + + +                        C  P +  
Sbjct: 1090 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1149

Query: 429  NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
             G   G     F  G T+ ++C       + + L G S I C     G  VWS+P PRC
Sbjct: 1150 YGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEIICLGG--GRRVWSAPLPRC 1197



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 139/652 (21%), Positives = 216/652 (33%), Gaps = 142/652 (21%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G   +      G  + +SC+ GYRL G+S   C + G   +W    P C  
Sbjct: 1142 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC-V 1198

Query: 164  IPCGLPPTITNGDFIS----TNRENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCT 216
              CG   T   G  +S     N EN H   + + +   G G     + F L         
Sbjct: 1199 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHL--------- 1248

Query: 217  SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 276
            +  D + I+ G      +    T  ++    L S +  L+     +EF        +G +
Sbjct: 1249 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQ 1303

Query: 277  RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 336
             V          EL  C       P +        D+ +F+ G  + Y C PGY L G++
Sbjct: 1304 LVYTSF------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSS 1351

Query: 337  SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-----FPVNLQLGAKVDFVCDEG 389
             ++C    +  W    P+C  +    F G+  +GR+L     FP +  L        D G
Sbjct: 1352 LLKCMTGERRAWDYPLPSCIAECGGRFKGE-SSGRILSPGYPFPYDNNLRCMWMIEVDPG 1410

Query: 390  ------FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF- 442
                  F    + AS+ +L     +W+        +   S  +IP G H+   +    F 
Sbjct: 1411 NIVSLQFLAFDTEASHDIL----RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFD 1466

Query: 443  ----------------------------------------GKTVNYTCDPHPDRGTSFDL 462
                                                    G TV + CDP       ++L
Sbjct: 1467 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP------GYEL 1520

Query: 463  IGESTIRCTSDPQGNGVWSSPAPRC---------GILGHCQAPDHFLFAKLKTQTNASDF 513
             GE  I C    +    W    P C         G  G   +P+   F      +   D+
Sbjct: 1521 QGEERITCI-QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN---FPHPYPHSRDCDW 1576

Query: 514  PIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573
             I  +  Y     +    FSI    + ++               PD  + ++    D ++
Sbjct: 1577 TITVNADYVISLAFIS--FSIEPNYDFLY-----------IYDGPDSNSPLIGSFQDSKL 1623

Query: 574  GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633
              RI  S  T H L   S      +G    +  K     R  C  P  I NG  +     
Sbjct: 1624 PERIESSSNTMH-LAFRSDGSVSYTGFHLEYKAK----LRESCFDPGNIMNGTRLGM--- 1675

Query: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            ++  GS VTY C+ G      + L G  ++ C   DD    W+   P C  P
Sbjct: 1676 DYKLGSTVTYYCDAG------YVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1721



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 706 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 760
           FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699

Query: 761 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 812
              +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 700 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757

Query: 813 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871
             L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 758 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 794

Query: 872 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
           P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 795 PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 845

Query: 932 SPAPRCGIL--GHCQAP 946
              P+CG    GH  AP
Sbjct: 846 GLIPKCGAPCGGHFSAP 862



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 1210
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 640  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699

Query: 1211 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 1262
               +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 700  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757

Query: 1263 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 1321
              L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 758  SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 794

Query: 1322 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
            P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 795  PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 845

Query: 1382 SPAPRCGIL--GHCQAP 1396
               P+CG    GH  AP
Sbjct: 846  GLIPKCGAPCGGHFSAP 862



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 184/870 (21%), Positives = 288/870 (33%), Gaps = 206/870 (23%)

Query: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 1333
            +  LG+ V F CDE + L+G+ +  C  +A + + W+   PVC+   C S    P+G  T
Sbjct: 461  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 520

Query: 1334 GKPLEVFPFGKAVNYTC----------DPHPDRGTSFDL-IGESTIRCTSDPQGNGVWSS 1382
                  FPF    N  C                   FDL IG  T+         G    
Sbjct: 521  SPN---FPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGD----GGEVGD 573

Query: 1383 PAPRCGILGHCQAPDHFLFAK----LKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438
            P     +L     PD  +       L  QT+ S   +G  + Y                 
Sbjct: 574  PRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY----------------- 616

Query: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 1498
                   K++ +++SC  P  P+ G +           + + C  G  LIG  S  C   
Sbjct: 617  -------KEI-EKESCGDPGTPLYG-IREGDGFSNRDVLRFECQFGFELIGEKSIVC--- 664

Query: 1499 GNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELV 1558
                 WS   PIC   PC    T   G  +S +           Y    G+    ++ ++
Sbjct: 665  QENNQWSANIPIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTII 712

Query: 1559 GEPS--IYCTSND-------DQVGIWSGPAPQCII------------------------- 1584
             +P   I+ + ND       D + +  G +P+  I                         
Sbjct: 713  SDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQ 772

Query: 1585 ------------------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKG 1624
                               N+C  P +  N     DN   F L   +   C+ GF+  +G
Sbjct: 773  ADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQG 829

Query: 1625 PRRVKCQALN---KWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681
               + C  ++    W   +P C   C        G H       FS    V  S  PG+ 
Sbjct: 830  TETITCILMDGKVMWSGLIPKCGAPC--------GGH-------FSAPSGVILS--PGWP 872

Query: 1682 LRGAASLHCTPQGDWSPEA-PRCAVK-SCDDFLGQLPHG--------RVLFPLNLQLGAK 1731
                 SL+C    +W  EA P  ++K + + F  +L +          +L PL   LG+ 
Sbjct: 873  GYYKDSLNC----EWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPL---LGSY 925

Query: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPV------CEHIFCPNPPAILNGRHTGT 1785
                  + F    S+  + +     S  NN   +           C +P   ++GR  G 
Sbjct: 926  NGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG- 983

Query: 1786 PSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGH 1845
               D   G  +S++CD        + L  E  + C      N  WS P P C+ ++  G 
Sbjct: 984  --HDFSIGSTVSFSCD------SGYRLSHEEPLLCEK----NHWWSHPLPTCD-ALCGGD 1030

Query: 1846 CKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRK 1905
             + P      SP  P  +F +P   +  +     + GK    +           D     
Sbjct: 1031 VRGPSG-TILSPGYP--EF-YPNSLNCTWTVDVTH-GKGVQFN-FHTFHLEDHHDYLLIT 1084

Query: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFR--LIGSPSTTCLVSGNNVTWDKKAPI 1963
              G   +P   +    T +    T+N      FR  L      +    G N+T+ +    
Sbjct: 1085 ENGSFTQPLARL----TGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---- 1136

Query: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 2023
              +  CE P     G     N   F  G  +T+ C +G      + L G   I C     
Sbjct: 1137 YNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSCSSG------YRLEGTSEIICLGGGR 1187

Query: 2024 QVGVWSSPPPRCISTNKCTAPEVENAIRVP 2053
            +  VWS+P PRC++    +A   E  +  P
Sbjct: 1188 R--VWSAPLPRCVAECGASATNNEGILLSP 1215



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 2/61 (3%)

Query: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSTKPPIC 1511
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S NTA W    PIC
Sbjct: 137  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195

Query: 1512 Q 1512
            +
Sbjct: 196  R 196



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 70/277 (25%), Positives = 100/277 (36%), Gaps = 34/277 (12%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSTKPPICQ 1512
            C  P +P NG   + +D  +GS + +SC   + L G  S  C  ++   A WS   P+C+
Sbjct: 446  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNLGSRGRKVFELVGEPSIYCT 1566
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 505  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562

Query: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 563  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612

Query: 1627 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
                  +N  E E  SC     P   I  G       D FS    + + C+ G++L G  
Sbjct: 613  -----KVNYKEIEKESCGDPGTPLYGIREG-------DGFSNRDVLRFECQFGFELIGEK 660

Query: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
            S+ C     WS   P C      +F    P G VL P
Sbjct: 661  SIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSP 695



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 140/645 (21%), Positives = 212/645 (32%), Gaps = 136/645 (21%)

Query: 1810 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG 1869
            F LIGE +I C      N  WS+  P C              FP  S      +F  P+G
Sbjct: 654  FELIGEKSIVCQE----NNQWSANIPICI-------------FPCLS------NFTAPMG 690

Query: 1870 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRR-------------------KSCGPP 1910
            T L+ +   GY   +       N +W+ + D   R                   K    P
Sbjct: 691  TVLSPDYPEGYGNNL-------NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 743

Query: 1911 PEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1970
              P  G     T  +  S +  S +   RL      +    G N+T++          C 
Sbjct: 744  ESPILGTF---TGAEVPSHLT-SNSHILRLEFQADHSMSGRGFNITYNTFGHN----ECP 795

Query: 1971 PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSS 2030
             P    N   + +N   F  G+ ++  C  G       +  G  +I C   D +V +WS 
Sbjct: 796  DPGIPINARRFGDN---FQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSG 846

Query: 2031 PPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG 2090
              P+C +            I  PG   ++  +      C+        H+++  T  R+ 
Sbjct: 847  LIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS----LNCEWVIEAEPGHSIKI-TFERFQ 901

Query: 2091 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
             +L +        P +L     L   +     Q +F S    Y L    +          
Sbjct: 902  TELNYDVLEVHDGPNLL--SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 959

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 2210
             E+      SC D  G   HGR     +  +G+ VSF CD G+RL   S    +L     
Sbjct: 960  YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014

Query: 2211 LWNSSVPVCE------------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT-HP 2257
             W+  +P C+             I  P  P         T   D+ +GK + +   T H 
Sbjct: 1015 WWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL 1074

Query: 2258 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL- 2316
            +    + LI E           NG ++ P  R           PP I  G Y      L 
Sbjct: 1075 EDHHDYLLITE-----------NGSFTQPLARL-----TGSDLPPTINAGLYGNFRAQLR 1118

Query: 2317 YLPGMTISYICDPGYLLVGKGFIF--CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEM 2374
            ++   +ISY    G+ +    +    C D GI      Y   +  +F +           
Sbjct: 1119 FISDFSISY---EGFNITFSEYNLEPCEDPGI----PQYGSRIGFNFGI----------- 1160

Query: 2375 KKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTS 2417
                  GD +T  C  GY LEG+    C    R  W  PL +C +
Sbjct: 1161 ------GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%)

Query: 554 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 612
           C  P +P NG   + +D  +GS + +SC   + L G  S  C       A WS   P+C+
Sbjct: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 613 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 666
              CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562

Query: 667 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 726
                 G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612

Query: 727 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 786
                 +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 613 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 660

Query: 787 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823
           S+ C     WS   P C      +F   +  G VL P
Sbjct: 661 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 695



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%)

Query: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 1062
            C  P +P NG   + +D  +GS + +SC   + L G  S  C       A WS   P+C+
Sbjct: 446  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504

Query: 1063 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 1116
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 505  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562

Query: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 563  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612

Query: 1177 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 1236
                  +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 613  -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 660

Query: 1237 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 1273
            S+ C     WS   P C      +F   +  G VL P
Sbjct: 661  SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 695



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 2/66 (3%)

Query: 97  DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWD 155
           +  +  SC NP  P  G+++  +    G +I+YSC  GY L G    TCI  S +T  WD
Sbjct: 131 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189

Query: 156 NETPIC 161
              PIC
Sbjct: 190 FPVPIC 195



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)

Query: 1900 DNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWD 1958
            +  +  SCG P  P  G+++  T    G  + YSC  G+ L G P  TC+  S N  +WD
Sbjct: 131  EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189

Query: 1959 KKAPIC 1964
               PIC
Sbjct: 190  FPVPIC 195



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 103  SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
            +CR+P  P+NG  +   G + G  + + C  GY L G    TCI   +   W    P+C 
Sbjct: 1487 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC- 1544

Query: 163  RIPCGLPPTITNGDFISTN 181
              PCG   T ++G  +S N
Sbjct: 1545 IAPCGGNLTGSSGFILSPN 1563



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 83/385 (21%), Positives = 138/385 (35%), Gaps = 90/385 (23%)

Query: 1866 FPVGTSLNYECRPGYFGKMF-SISCLENLV----WSSVEDNCRRK-SCGPPPEPFNGMVH 1919
            F VG  + Y C  GY       ++C+ N V    W      CR + +CG      +G++ 
Sbjct: 154  FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII- 212

Query: 1920 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP------- 1972
              +   F +  + + +  + ++  P  T  +   +   ++K    EI   EPP       
Sbjct: 213  --SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 270

Query: 1973 ----PTISNGDFY-------SNNR-----TSFHNGTVVTYQCHTGPDGEQLFELVGERSI 2016
                P ISN ++        SN+R       +   + +T+   TG   E      G  ++
Sbjct: 271  NIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAV 330

Query: 2017 YCT-----------------SKDDQVGVWS---------------SPPPRCISTNKCTAP 2044
              T                 S++ +V V S               SP P   +  + T  
Sbjct: 331  ASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHP---ADTQSTRR 387

Query: 2045 EVENAIRVPGNRSFFTLTEIIR---------FRCQPGFVMVGSHTVQCQTNGRWGPKLPH 2095
               +A ++   +    +T  ++         F+  PG     S+       G     +  
Sbjct: 388  RPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPG--KDNSNKFSILNEGG----IKT 441

Query: 2096 CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD----WSP 2151
             S +C  P E  +G+   S   +FS G  V +SC+  Y L+GA S+ C    +    WS 
Sbjct: 442  ASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 498

Query: 2152 EAPRCTVKSCDDFLGQLPHGRVLLP 2176
              P C VK+C   L Q P G    P
Sbjct: 499  HRPVCKVKTCGSNL-QGPSGTFTSP 522



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 8/91 (8%)

Query: 1637 EPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD- 1695
            E  + + S +C  P E  +G+   S   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 436  EGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492

Query: 1696 ---WSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
               WS   P C VK+C   L Q P G    P
Sbjct: 493  FAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 522



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%)

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 345
           E  + + S +C   PD    E  +R   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 436 EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492

Query: 346 ---WSPAAPTCEVKSC 358
              WS   P C+VK+C
Sbjct: 493 FAAWSDHRPVCKVKTC 508



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%)

Query: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 1245
            E  + + S +C   PD    E  +R   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 436  EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492

Query: 1246 ---WSPAAPTCEVKSC 1258
               WS   P C+VK+C
Sbjct: 493  FAAWSDHRPVCKVKTC 508



 Score = 38.9 bits (89), Expect = 0.064
 Identities = 146/721 (20%), Positives = 228/721 (31%), Gaps = 238/721 (33%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQ--IKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
            ++SC +P  P+ G   + +G  F ++  +++ C  G+ LIG  S  C  +     W    
Sbjct: 621  KESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ---WSANI 674

Query: 159  PICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCT 216
            PIC   PC    T   G  +S +           Y    G+    ++ ++ +P   I+ +
Sbjct: 675  PIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTIISDPGSRIHLS 722

Query: 217  SND-------DQVGIWSGPAPQCII----------------------------------- 234
             ND       D + +  G +P+  I                                   
Sbjct: 723  FNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782

Query: 235  --------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPRRVKCQALN 284
                     N+C  P +  N     DN   F L   +   C+ GF+  +G   + C  ++
Sbjct: 783  NITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMD 839

Query: 285  ---KWEPELPSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFY----SCEPGYDLR 333
                W   +P C   C      P  V+            SPG   +Y    +CE   +  
Sbjct: 840  GKVMWSGLIPKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDSLNCEWVIEAE 888

Query: 334  GAASMRCT-PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-----CD 387
               S++ T  +          EV    + +  LL       V   L +  +F+      D
Sbjct: 889  PGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTD 948

Query: 388  EGFQLKGSSASY-CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTV 446
                  G    Y  V     S  +  +PV             +GR  G     F  G TV
Sbjct: 949  NSRSNNGFKIHYESVTVNTYSCLDPGIPV-------------HGRRYGHD---FSIGSTV 992

Query: 447  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKL 504
            +++CD      + + L  E  + C    + N  WS P P C  L  G  + P        
Sbjct: 993  SFSCD------SGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVRGPS------- 1035

Query: 505  KTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 564
                       GT L     PE+Y  P S+ C     W+                     
Sbjct: 1036 -----------GTILS-PGYPEFY--PNSLNC----TWT--------------------- 1056

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN 624
                 D+  G  + ++  T H    H       +G     S   P+ +     LPPTI  
Sbjct: 1057 ----VDVTHGKGVQFNFHTFHLEDHHDYLLITENG-----SFTQPLARLTGSDLPPTINA 1107

Query: 625  G---------DFIST-----------------------------NRENFHY--GSVVTYR 644
            G          FIS                              +R  F++  G  +T+ 
Sbjct: 1108 GLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFS 1167

Query: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRS 704
            C+ G      + L G   I C     +V  WS P P+C+     +  N E GIL+S N  
Sbjct: 1168 CSSG------YRLEGTSEIICLGGGRRV--WSAPLPRCVAECGASATNNE-GILLSPNYP 1218

Query: 705  L 705
            L
Sbjct: 1219 L 1219



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 7/66 (10%)

Query: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTD----QGIWSQLDHY 2353
            CP P + +NG  IG   SL   G T+ + CD  Y+L G   I C         WS     
Sbjct: 446  CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502

Query: 2354 CKEVNC 2359
            CK   C
Sbjct: 503  CKVKTC 508



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 19/113 (16%)

Query: 1539 SVVTYRC----NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1594
            +VVT+R     +  SRG K+F      + +   N+  +   S   P         P   E
Sbjct: 402  AVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPD--------PGEPE 453

Query: 1595 NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1643
            NG  +  +   FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 454  NGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503



 Score = 35.0 bits (79), Expect = 0.92
 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%)

Query: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
           ++  PG      F ++ E  I   SN              + P+   P   ENG  +  +
Sbjct: 419 FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 461

Query: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 293
              FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 462 ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503



 Score = 35.0 bits (79), Expect = 0.92
 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%)

Query: 1093 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 1152
            ++  PG      F ++ E  I   SN              + P+   P   ENG  +  +
Sbjct: 419  FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 461

Query: 1153 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1193
               FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 462  ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 2178 NLQLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC 2224
            +  LG+ V F CDE + L+G  +  C  +A + A W+   PVC+   C
Sbjct: 461  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 508



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 2378 YHYGDYVTLKCEDGYTLEGSPWSQCQADD--RWDPPLAKCTSRTHDAL 2423
            Y  GD V+ +C+ GY+L+G     C      RW+ P+  C ++   A+
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2075



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 343
           E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184

Query: 344 -GDWSPAAPTCEVKSCDDFMGQLLNG 368
              W    P C     +D  G  + G
Sbjct: 185 TASWDFPVPICR---AEDACGGTMRG 207



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 793
           E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184

Query: 794 -GDWSPAAPTCEVKSCDDFMGQLLNG 818
              W    P C     +D  G  + G
Sbjct: 185 TASWDFPVPICR---AEDACGGTMRG 207



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 1243
            E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 132  ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184

Query: 1244 -GDWSPAAPTCEVKSCDDFMGQLLNG 1268
               W    P C     +D  G  + G
Sbjct: 185  TASWDFPVPICR---AEDACGGTMRG 207



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
           Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184

Query: 672 VGIWSGPAPQCIIPNKC 688
              W  P P C   + C
Sbjct: 185 TASWDFPVPICRAEDAC 201



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 134  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184

Query: 1122 VGIWSGPAPQCIIPNKC 1138
               W  P P C   + C
Sbjct: 185  TASWDFPVPICRAEDAC 201



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 134  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184

Query: 1572 VGIWSGPAPQCIIPNKC 1588
               W  P P C   + C
Sbjct: 185  TASWDFPVPICRAEDAC 201



 Score = 32.3 bits (72), Expect = 6.0
 Identities = 20/73 (27%), Positives = 25/73 (34%), Gaps = 9/73 (12%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           CG P     G    T    F  G  + Y C  G      + L G P + C +N      W
Sbjct: 138 CGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVNTASW 188

Query: 226 SGPAPQCIIPNKC 238
             P P C   + C
Sbjct: 189 DFPVPICRAEDAC 201


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  410 bits (1053), Expect = e-113
 Identities = 485/1932 (25%), Positives = 724/1932 (37%), Gaps = 356/1932 (18%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159
            R+SC +P + +NG   +    + GS + Y C  GY L G S+ TCI+  D    W+   P
Sbjct: 1698 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756

Query: 160  ICDRIPCGLPPTITNGDFISTNR-ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
             C   PCG   T + G  +S N  +N+  G    + C       K F + G+   + TS 
Sbjct: 1757 SC-HAPCGSRSTGSEGTVLSPNYPKNYSVG----HNCVYSIAVPKEFVVFGQFVFFQTSL 1811

Query: 219  DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
             D V ++ GP  Q  + +  +  +    + +S    +      + F        KG   V
Sbjct: 1812 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKGFHFV 1866

Query: 279  KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338
              QA+ +       CS V +P          +R  + F+ G  V + C PGY L G+ ++
Sbjct: 1867 Y-QAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAI 1916

Query: 339  RC----TPQGDWSPAAPTCEVKSCDDFM----GQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
            RC         W+ + PTC +  C   +    G +L+     P +  L         EG 
Sbjct: 1917 RCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGA 1975

Query: 391  QLKGSSASYCVLAGMESL-----------------------------------WNSSVPV 415
             ++    S+      +SL                                   + S + V
Sbjct: 1976 GIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISV 2035

Query: 416  CEQIF-----------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464
                F           CP P    +G   G   + +  G  V++ CD        + L G
Sbjct: 2036 SAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCD------QGYSLQG 2086

Query: 465  ESTIRCTSDPQGNGVWSSPAPRC------------GILGHCQAPD--------------- 497
             S I C   P     W+ P P C            G++     P                
Sbjct: 2087 HSHITCMPGPVRR--WNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2144

Query: 498  -----HFLFAKLKTQT-------NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSP 545
                 H  F    T+T        +      T +     P+     FS T   +L + S 
Sbjct: 2145 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD 2204

Query: 546  KDVCKR-----------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
                K+           +SC  P    NG V +  D  VG  I++ C  G+ LIG+S+  
Sbjct: 2205 YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALT 2263

Query: 595  CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGG 651
            C L G + +W+   P C+ + CG   T  NG   S    + +      +   R  PG+G 
Sbjct: 2264 C-LHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2321

Query: 652  RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 711
               F ++    IY     D + +W GP            P +      +   S++S +  
Sbjct: 2322 YINFTVLQTEPIY-----DFITVWDGPDQ--------NSPQIGQFSGNTALESVYSTSNQ 2368

Query: 712  VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771
            +  +    F   G   +   A            RVCQPPP V +AE    D D F  G  
Sbjct: 2369 ILIKFHSDFTTSGFFVLSYHAYQ---------LRVCQPPPPVPNAEILTED-DEFEIGDI 2418

Query: 772  VFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP------ 823
            + Y C PG+ L G A + C    +     A P C+V    + +     G +L P      
Sbjct: 2419 IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSY 2478

Query: 824  VNLQLGAKVDFVCDEGFQL-------------------KGSSASYCVLAGMESLWNSSVP 864
             NLQ+ A      ++G+ +                    G +    VL  +   ++S+  
Sbjct: 2479 PNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2537

Query: 865  VCEQ-------------------------IFCPSPPVIPNG---RHTGKPLEVFPFGKTV 896
            +                             +C +P   P+G     TG  L        V
Sbjct: 2538 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL-----NSVV 2592

Query: 897  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 956
             + C    DRG  F L+G+S+  C     G   W +P P C  +  C  P        K 
Sbjct: 2593 RWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KA 2637

Query: 957  QTN----ASDFPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTP 1007
             TN     +D+ +GT + Y C   Y      +T   C  +  WS+      C   +C + 
Sbjct: 2638 PTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSI 2697

Query: 1008 PDPV--NGMVHVI--TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063
               +  +G   ++  +  +  +++ +SC  G+  +G +S EC+ +G  + W  + P CQ 
Sbjct: 2698 NSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQI 2756

Query: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
            I CG  PT  NG+ I T      YGS   + C+ G      F LVG     C S+    G
Sbjct: 2757 ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRECLSS----G 2803

Query: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183
            +WS    +C+  +   P  + NG ++ +N   +   + V ++C PGF + G     CQ  
Sbjct: 2804 LWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIGSSVRICQQD 2860

Query: 1184 NKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 1242
            + W  +LPSC  V C  P   ++  RT  +  NF+    V +SC  GY ++G    +C  
Sbjct: 2861 HNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQGPTKAQCQA 2917

Query: 1243 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEGFQLKGSSASY 1299
               WS   P C+V +C D  G   N +    +   N   G  V + C+ G+ L GSS   
Sbjct: 2918 NRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2976

Query: 1300 CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTS 1359
            C   G    W+  +P C  I C  P V PN   +G   E + FG  V+Y+C         
Sbjct: 2977 CQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCT------GK 3024

Query: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKLKTQTNASDFP 1414
              L+G+S+  C    Q NG WS   P C     G  G    P H            S+F 
Sbjct: 3025 RSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH-------GSRQESNFR 3073

Query: 1415 IGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQ 1472
              ++++Y C   Y  +G     TCL N  W+  +  CK   C  P    NG V  I    
Sbjct: 3074 TKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT 3132

Query: 1473 VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNR 1532
              S + YSC  G+ L G S  +C  +G    WS   P C  I CG P   ANG       
Sbjct: 3133 FSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANG---LRYG 3186

Query: 1533 ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1592
            +++  G  V+Y C  G       EL G     CT N    G WSG  P C      TPP 
Sbjct: 3187 DDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQ 3238

Query: 1593 VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVCQPPP 1651
            + NG L   N   F     + + C PG+ +  P  + C     W  E+P C  + C  P 
Sbjct: 3239 ISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3295

Query: 1652 EILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC---AVKSC 1708
                G+       +F    EV +SC   + L G+++  C   G WS  +P C      SC
Sbjct: 3296 IPAQGKR---EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3352

Query: 1709 DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEH 1768
            ++  G   HG        Q+G+ V F C +G  L+GS+   C+       W+   P C  
Sbjct: 3353 EN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIP 3408

Query: 1769 IFCPNPPAILNGRHTGTPSGDIP-YGKEISYTCDPHPDRGMTFNLIGESTIR-CTSDPHG 1826
              C  P       H      D+P +G  + YTC P       F L G +  R C SD   
Sbjct: 3409 HSCKQPE---TPAHANVVGMDLPSHGYTLIYTCQP------GFFLAGGTEHRVCRSD--- 3456

Query: 1827 NGVWSSPAPRCE 1838
               W+   P CE
Sbjct: 3457 -NTWTGKVPICE 3467



 Score =  338 bits (866), Expect = 5e-92
 Identities = 289/974 (29%), Positives = 406/974 (41%), Gaps = 103/974 (10%)

Query: 1267 NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 1325
            +G ++     QL + V + CD GF+L G S++ C  +      W++ VP C+ I C  P 
Sbjct: 2577 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2636

Query: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 1383
               NG   G     +  G  V Y C+    R +S +L   +T  C SD    G WS+   
Sbjct: 2637 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2685

Query: 1384 APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 1441
             PRC ++  C + + F+    + +  N S +   T + + C P Y+G  P SI CL N  
Sbjct: 2686 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2744

Query: 1442 WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1499
            WS  + +  C+  SC   P P NG   + T    GS   ++C  G  L+G +  EC+ SG
Sbjct: 2745 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2803

Query: 1500 NTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVG 1559
                WS     C    CG+P  I NG  I    EN+ Y   V Y+CN G      F L+G
Sbjct: 2804 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2851

Query: 1560 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1619
                 C  + +    WSG  P C+ P  C  P   + I    + + F+ N+VV F C  G
Sbjct: 2852 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2904

Query: 1620 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPS--HQDNFSPGQEVFYSCE 1677
            ++M+GP + +CQA  +W    P C  V    P I       S     NF+ G  VFY C 
Sbjct: 2905 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2964

Query: 1678 PGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCD 1737
            PGY L G++ L C P G W    P C +  C      +P   VL       G+ V + C 
Sbjct: 2965 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 3022

Query: 1738 EGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI---FCPNPPAILNGRHTGTPSGDIPYGK 1794
                L G S   C L G    W+ S P C       C +P       H      +     
Sbjct: 3023 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKS 3076

Query: 1795 EISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPF 1854
             + Y CD        + L G     C +    NG W+   P C+ +V+ G+  T      
Sbjct: 3077 TVRYACD------TGYILHGSEERTCLA----NGSWTGRQPECK-AVQCGNPGTTAN--- 3122

Query: 1855 ASPTIPINDFEFPVGTSLNYECRPGYFGKMFSI-SCLENLVWSSVEDNCRRKSCGPPPEP 1913
                  I+   F   +S+ Y C  GY     S+  C  N  WS    NC   SCG P  P
Sbjct: 3123 -GKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIP 3179

Query: 1914 FNGMVHINTDTQFGSTVNYSCNEGF--RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP 1971
             NG+     D   G  V+Y C  G+   L GS   TC ++G   TW    P C  ++C  
Sbjct: 3180 ANGL-RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING---TWSGVMPTCRAVTCPT 3235

Query: 1972 PPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP 2031
            PP ISNG       T+F  G  ++Y C  G      +EL     + C       G WS  
Sbjct: 3236 PPQISNGRL---EGTNFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGE 3282

Query: 2032 PPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
             P+C+    C  P +    +  G +SF   +E + F C   F++VGS T  CQ +G W  
Sbjct: 3283 VPQCL-PKFCGDPGIPAQGKREG-KSFIYQSE-VSFSCNFPFILVGSSTRICQADGTWSG 3339

Query: 2092 KLPHC----SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQG 2147
              PHC       C+ P    HG    ++   F  G  V + C+  + L+G+ +  C P  
Sbjct: 3340 SSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL 3397

Query: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL-QLGAKVSFVCDEGFRLKGRSASHCVLA 2206
             WS   P C   SC     + P    ++ ++L   G  + + C  GF L G    H V  
Sbjct: 3398 TWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAG-GTEHRVCR 3454

Query: 2207 GMKALWNSSVPVCE 2220
                 W   VP+CE
Sbjct: 3455 SDNT-WTGKVPICE 3467



 Score =  334 bits (856), Expect = 7e-91
 Identities = 296/1001 (29%), Positives = 414/1001 (41%), Gaps = 122/1001 (12%)

Query: 817  NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 875
            +G ++     QL + V + CD GF+L G S++ C  +      W++ VP C+ I C  P 
Sbjct: 2577 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2636

Query: 876  VIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 933
               NG   G     +  G  V Y C+    R +S +L   +T  C SD    G WS+   
Sbjct: 2637 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2685

Query: 934  APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 991
             PRC ++  C + + F+    + +  N S +   T + + C P Y+G  P SI CL N  
Sbjct: 2686 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2744

Query: 992  WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1049
            WS  + +  C+  SC   P P NG   + T    GS   ++C  G  L+G +  EC+ SG
Sbjct: 2745 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2803

Query: 1050 NAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109
                WS     C    CG+P  I NG  I    EN+ Y   V Y+CNPG      F L+G
Sbjct: 2804 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2851

Query: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169
                 C  + +    WSG  P C+ P  C  P   + I    + + F+ N+VV F C  G
Sbjct: 2852 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2904

Query: 1170 FVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCE 1227
            ++M+GP + +CQA  +W    P C  V C  P    +++R  + +  NF+ G  VFY C 
Sbjct: 2905 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2964

Query: 1228 PGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCD 1287
            PGY L G++ + C P G W    P C +  C      +    VL       G+ V + C 
Sbjct: 2965 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 3022

Query: 1288 EGFQLKGSSASYCVLAGMESLWNSSVPVC--EQIFCPSPPVIPNGRHTGKPLEVFPFGKA 1345
                L G S+  C L G    W+ S P C  +       P  P   H  +    F     
Sbjct: 3023 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG--HGSRQESNFRTKST 3077

Query: 1346 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 1405
            V Y CD      T + L G     C +    NG W+   P C  +  C  P         
Sbjct: 3078 VRYACD------TGYILHGSEERTCLA----NGSWTGRQPECKAV-QCGNPG-------- 3118

Query: 1406 TQTNASDFPI-----GTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPD 1459
            T  N   F I      +S+ Y C   Y    P    C  N  WS     C   SC  P  
Sbjct: 3119 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGI 3178

Query: 1460 PVNGMVHVITDIQVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSTKPPICQRIPCG 1517
            P NG+ +   D  VG  ++Y C  G+   L G     C ++G    WS   P C+ + C 
Sbjct: 3179 PANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCP 3234

Query: 1518 LPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSG 1577
             PP I+NG    T   NF +G  ++Y C+ G      +EL     + C  N    G WSG
Sbjct: 3235 TPPQISNGRLEGT---NFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSG 3281

Query: 1578 PAPQCIIPNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1635
              PQC +P  C  P    GI     R    F     V F C   F++ G     CQA   
Sbjct: 3282 EVPQC-LPKFCGDP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT 3336

Query: 1636 WEPELPSC----SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT 1691
            W    P C       C+ P    HG  + ++   F  G  V + C+ G+ L+G+ +  C 
Sbjct: 3337 WSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3394

Query: 1692 PQGDWSPEAPRCAVKSCDDFLGQLP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1750
            P   WS   P C   SC     + P H  V+       G  + + C  GF L G +    
Sbjct: 3395 PDLTWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR- 3451

Query: 1751 VLVGMRSLWNNSVPVCE---HIFCPNP-PAILNGRHTGTPS 1787
             +    + W   VP+CE    I   +P PA+      GTPS
Sbjct: 3452 -VCRSDNTWTGKVPICEAGSKILVKDPRPAL------GTPS 3485



 Score =  321 bits (823), Expect = 5e-87
 Identities = 274/992 (27%), Positives = 410/992 (41%), Gaps = 124/992 (12%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH-WSTKPPICQ 1512
            C TP  P +G +   T  Q+ S + ++C  G RL+G SSA C  S    H W    P CQ
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
             I CG+P    NG  ++T   ++  G+ VTY CN G R     EL    +  C S+    
Sbjct: 2629 AISCGIPKAPTNGGILTT---DYLVGTRVTYFCNDGYR-LSSKELT---TAVCQSD---- 2677

Query: 1573 GIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFVMKGP 1625
            G WS     P+C++    T P++ + IL        N S +     V F C PG+   GP
Sbjct: 2678 GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGP 2734

Query: 1626 RRVKC--QALNKWEPELP-----SCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1678
              ++C       W  E P     SC  +  PP     G  T       S G    ++C+ 
Sbjct: 2735 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTCDL 2787

Query: 1679 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738
            G+ L G+A   C   G WS    RC    C   + +L     +   N      V + C+ 
Sbjct: 2788 GFMLVGSAVRECLSSGLWSESETRCLAGHCG--IPELIVNGQVIGENYGYRDTVVYQCNP 2845

Query: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
            GFRL GSSV  C        W+  +P C  + C +P + + GR +G       +   +++
Sbjct: 2846 GFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTF 2899

Query: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1858
            +C+      + + + G +  +C      N  WS P P C++     +C  P     +   
Sbjct: 2900 SCN------IGYLMQGPTKAQC----QANRQWSHPPPMCKVV----NCSDPGIPANSKRE 2945

Query: 1859 IPINDFEFPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFN 1915
              I    F  GT + Y+C PGYF  +F  S   C  N  W      C    CG P  P N
Sbjct: 2946 SKIEHGNFTYGTVVFYDCNPGYF--LFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN 3003

Query: 1916 GMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE---IISCEPP 1972
             ++     T FGSTV+YSC     L+G  S TC ++G+   W    P C      +C  P
Sbjct: 3004 AVLSGEKYT-FGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDP 3059

Query: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032
             T  +G   S   ++F   + V Y C TG      + L G     C +     G W+   
Sbjct: 3060 GTPGHG---SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQ 3106

Query: 2033 PRCISTNKCTAPEVE---NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 2089
            P C +  +C  P         R+ G     T +  + + C  G+++ G    QC  NG W
Sbjct: 3107 PECKAV-QCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTANGTW 3161

Query: 2090 GPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY--DLRGAASLHCTPQG 2147
               LP+C+ +    P I    + L + D++  GQ V Y C+P Y  +L G+    CT  G
Sbjct: 3162 SGTLPNCTIISCGDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3219

Query: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAG 2207
             WS   P C   +C     Q+ +GR L   N   G  +S++C  G+ L   +   CV  G
Sbjct: 3220 TWSGVMPTCRAVTCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG 3277

Query: 2208 MKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 2267
                W+  VP C   FC +P     G+  G  F    Y  E+S++C+        F L+G
Sbjct: 3278 ---TWSGEVPQCLPKFCGDPGIPAQGKREGKSF---IYQSEVSFSCN------FPFILVG 3325

Query: 2268 ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYIC 2327
             S+  C    Q +G WS  +P C      +C +P   ++G     +   +  G  + + C
Sbjct: 3326 SSTRIC----QADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHC 3379

Query: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC---SFPLFMNGISKELEMKKVYHYGDYV 2384
              G+LL G     C     WS +   C   +C     P   N +  +L       +G  +
Sbjct: 3380 KKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLP-----SHGYTL 3434

Query: 2385 TLKCEDGYTLEGSPWSQ-CQADDRWDPPLAKC 2415
               C+ G+ L G    + C++D+ W   +  C
Sbjct: 3435 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3466



 Score =  299 bits (766), Expect = 2e-80
 Identities = 244/822 (29%), Positives = 336/822 (40%), Gaps = 94/822 (11%)

Query: 67   TYLNYECRPGYSGR-PFSIICLKNSVWTGAKDR--CRRKSCRNPPDPVNGMVHVIKGIQF 123
            T + + C PGY G  P SI CL N  W+   +R  C+  SC   P P NG   +     +
Sbjct: 2719 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSY 2777

Query: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183
            GS   ++C  G+ L+GS+   C+ SG   +W      C    CG+P  I NG  I    E
Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQVIG---E 2831

Query: 184  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243
            N+ Y   V Y+CNPG      F L+G     C  + +    WSG  P C+ P  C  P  
Sbjct: 2832 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2879

Query: 244  ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPD 302
             + I    + + F+ N+VV F C  G++M+GP + +CQA  +W    P C  V C  P  
Sbjct: 2880 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2938

Query: 303  VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
              +++R  + +  NF+ G  VFY C PGY L G++ + C P G W    P C +  C   
Sbjct: 2939 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2997

Query: 362  MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC--EQI 419
               +    VL       G+ V + C     L G S+  C L G    W+ S P C  +  
Sbjct: 2998 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3053

Query: 420  FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479
                 P  P   H  +    F    TV Y CD      T + L G     C +    NG 
Sbjct: 3054 GTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA----NGS 3101

Query: 480  WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTSLKYECRPEY-YGRPFS 533
            W+   P C  +  C  P         T  N   F I      +S+ Y C   Y    P  
Sbjct: 3102 WTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSV 3152

Query: 534  ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH--RLIGHS 591
              C  N  WS     C   SC  P  P NG+ +   D  VG  ++Y C  G+   L G  
Sbjct: 3153 RQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSR 3211

Query: 592  SAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGG 651
               C ++G    WS   P C+ + C  PP I+NG    T   NF +G  ++Y C+PG   
Sbjct: 3212 IRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYICSPG--- 3262

Query: 652  RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR--SLFSLN 709
               +EL     + C  N    G WSG  PQC +P  C  P    GI     R    F   
Sbjct: 3263 ---YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP----GIPAQGKREGKSFIYQ 3310

Query: 710  EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQPPPDVLHAERTQRDKDN 765
              V F C   F++ G     CQA   W    P C       C+ P    H   +Q +   
Sbjct: 3311 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFG 3368

Query: 766  FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN 825
            F  G  V + C+ G+ L+G+ +  C P   WS   P C   SC        +  V+    
Sbjct: 3369 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-PETPAHANVVGMDL 3427

Query: 826  LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867
               G  + + C  GF L G +     +   ++ W   VP+CE
Sbjct: 3428 PSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICE 3467



 Score =  295 bits (755), Expect = 4e-79
 Identities = 446/1993 (22%), Positives = 711/1993 (35%), Gaps = 411/1993 (20%)

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGI 697
            GS + Y CNPG      + L G   + C + + +   W  P P CI           +G 
Sbjct: 1374 GSTIIYGCNPG------YTLHGSSLLKCMTGERRA--WDYPLPSCIAECGGRFKGESSGR 1425

Query: 698  LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD----- 752
            ++S        N +   RC     +     V  Q L           RV   PP+     
Sbjct: 1426 ILSPGYPFPYDNNL---RCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLL 1482

Query: 753  --------------VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
                           L+    Q D D        FY  + G+ ++ ++S+    +    P
Sbjct: 1483 KEISGSLIPEGIHSTLNIVTIQFDTD--------FYISKSGFAIQFSSSVATACR---DP 1531

Query: 799  AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
              P    ++ D        GR       + G  V F CD G++L+G     C+       
Sbjct: 1532 GVPMNGTRNGD--------GR-------EPGDTVVFQCDPGYELQGEERITCIQVENRYF 1576

Query: 859  WNSSVPVCEQIFCPSPPVIP-NGRHTGKPLEV--------FPFGKTVNYTCDPHPDRGTS 909
            W  S PVC         + P  G  TG    +        +P  +  ++T   + D   S
Sbjct: 1577 WQPSPPVC---------IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVIS 1627

Query: 910  FDLIGESTIRCTSDPQGNG--VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGT 967
               I  S      +P  +   ++  P     ++G  Q       +KL  +  +S   +  
Sbjct: 1628 LAFISFSI-----EPNYDFLYIYDGPDSNSPLIGSFQD------SKLPERIESSSNTMHL 1676

Query: 968  SLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1027
            + + +    Y G  F +     L          R+SC  P + +NG   +  D ++GS +
Sbjct: 1677 AFRSDGSVSYTG--FHLEYKAKL----------RESCFDPGNIMNG-TRLGMDYKLGSTV 1723

Query: 1028 NYSCTTGHRLIGHSSAECILSGNAAH-WSTKPPICQRIPCGLPPTIANGDFISTNR-ENF 1085
             Y C  G+ L G+S+  CI+  +    W+   P C   PCG   T + G  +S N  +N+
Sbjct: 1724 TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNY 1782

Query: 1086 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 1145
              G    + C       K F + G+   + TS  D V ++ GP  Q  + +  +  +   
Sbjct: 1783 SVG----HNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGE 1838

Query: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 1205
             + +S    +      + F        KG   V  QA+ +       CS V +P      
Sbjct: 1839 SLPLSSGNQI-----TIRFTSVGPITAKGFHFVY-QAVPRTSST--QCSSVPEP------ 1884

Query: 1206 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC----TPQGDWSPAAPTCEVKSCDDF 1261
                +R  + F+ G  V + C PGY L G+ ++RC         W+ + PTC +  C   
Sbjct: 1885 -RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGI 1942

Query: 1262 M----GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL--------- 1308
            +    G +L+     P +  L         EG  ++    S+      +SL         
Sbjct: 1943 LTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 2002

Query: 1309 --------------------------WNSSVPVCEQIF-----------CPSPPVIPNGR 1331
                                      + S + V    F           CP P    +G 
Sbjct: 2003 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGI 2062

Query: 1332 HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 1387
              G   + +  G  V++ CD        + L G S I C   P     W+ P P C    
Sbjct: 2063 KIG---DRYMVGDVVSFQCDQ------GYSLQGHSHITCMPGPVRR--WNYPIPICLAQC 2111

Query: 1388 --------GILGHCQAPD--------------------HFLFAKLKTQT-------NASD 1412
                    G++     P                     H  F    T+T        +  
Sbjct: 2112 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2171

Query: 1413 FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKR-----------KSCKTPPDPV 1461
                T +     P+     FS T   +L + S     K+           +SC  P    
Sbjct: 2172 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 2231

Query: 1462 NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPT 1521
            NG V +  D  VG  I++ C  G+ LIG+S+  C L G + +W+   P C+ + CG   T
Sbjct: 2232 NGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRCEAL-CGGNIT 2288

Query: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKV---FELVGEPSIYCTSNDDQVGIWSGP 1578
              NG   S    + +      +       G  +   F ++    IY     D + +W GP
Sbjct: 2289 AMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY-----DFITVWDGP 2343

Query: 1579 APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP 1638
                        P +      +   S++S +  +  +    F   G   +   A      
Sbjct: 2344 DQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQL--- 2392

Query: 1639 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP----QG 1694
                  RVCQPPP + + E   +  D F  G  + Y C PG+ L G A L C      Q 
Sbjct: 2393 ------RVCQPPPPVPNAEIL-TEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQM 2445

Query: 1695 DWSPEAPRCAVKSCDDFLGQLPHGRVLFP------LNLQLGAKVSFVCDEGFRLK----- 1743
            D +P  P C V    + L     G +L P       NLQ+ A  S   ++G+ +      
Sbjct: 2446 DGAP--PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAW-SISVEKGYNITMFVEF 2502

Query: 1744 --------------GSSVSHCVLVGMRSLWNNSVPVCEH--------------------- 1768
                          G ++   VL+ +   ++++  +  +                     
Sbjct: 2503 FQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRI 2562

Query: 1769 ----IFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP 1824
                 +C  P +  +G       G +     + + CD    RG  F L+G+S+  C    
Sbjct: 2563 RYIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACD----RG--FRLVGKSSAVCRKSS 2614

Query: 1825 HGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY---F 1881
            +G   W +P P C+ ++  G  K P      +        ++ VGT + Y C  GY    
Sbjct: 2615 YGYHAWDAPVPACQ-AISCGIPKAPTNGGILTT-------DYLVGTRVTYFCNDGYRLSS 2666

Query: 1882 GKMFSISCLENLVWSSVEDN--CRRKSCGPPPEPF---NGMVHI--NTDTQFGSTVNYSC 1934
             ++ +  C  +  WS+      C   +C P    F   +G   I   +  ++ + V +SC
Sbjct: 2667 KELTTAVCQSDGTWSNHNKTPRCVVVTC-PSINSFILEHGRWRIVNGSHYEYKTKVVFSC 2725

Query: 1935 NEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVV 1994
            + G+  +G  S  CL +G   +W  + P C+IISC   PT  NG+     +TS+  G+  
Sbjct: 2726 DPGYHGLGPASIECLPNGT-WSWRNERPYCQIISCGELPTPPNGNKIGT-QTSY--GSTA 2781

Query: 1995 TYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPG 2054
             + C  G      F LVG     C S     G+WS    RC++ + C  PE+    +V G
Sbjct: 2782 IFTCDLG------FMLVGSAVRECLSS----GLWSESETRCLAGH-CGIPELIVNGQVIG 2830

Query: 2055 NRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTL 2113
                +   + + ++C PGF ++GS    CQ +  W  +LP C  V C  P   ++G    
Sbjct: 2831 EN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--- 2885

Query: 2114 SHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDD--------FL 2165
            +  + F+    V +SC   Y ++G     C     WS   P C V +C D          
Sbjct: 2886 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRE 2945

Query: 2166 GQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCP 2225
             ++ HG      N   G  V + C+ G+ L G S   C   G    W+  +P C  I C 
Sbjct: 2946 SKIEHG------NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCG 2996

Query: 2226 NPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS 2285
            +P    N   +G  +    +G  + Y+C          +L+G+SS  C    Q NG WS 
Sbjct: 2997 HPGVPPNAVLSGEKY---TFGSTVHYSCTGKR------SLLGQSSRTC----QLNGHWSG 3043

Query: 2286 PAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 2345
              P C       C  P    +G       S +    T+ Y CD GY+L G     C   G
Sbjct: 3044 SQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 3100

Query: 2346 IWSQLDHYCKEVNCSFPLFMNGISKELEMKKV--YHYGDYVTLKCEDGYTLEGSPWSQCQ 2403
             W+     CK V C  P    G +   ++ ++    +   V   C +GY L G    QC 
Sbjct: 3101 SWTGRQPECKAVQCGNP----GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3156

Query: 2404 ADDRWDPPLAKCT 2416
            A+  W   L  CT
Sbjct: 3157 ANGTWSGTLPNCT 3169



 Score =  273 bits (698), Expect = 2e-72
 Identities = 269/980 (27%), Positives = 386/980 (39%), Gaps = 167/980 (17%)

Query: 43   CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTGAK 96
            C+ PE  P     + T      + + + + C  G+   G+  S +C K+S     W    
Sbjct: 2569 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2624

Query: 97   DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD- 155
              C+  SC  P  P NG + +      G+++ Y C  GYRL      T +   D   W  
Sbjct: 2625 PACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSN 2682

Query: 156  -NETPICDRIPCGLPPTIT-----NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 209
             N+TP C  + C   P+I      +G +   N  ++ Y + V + C+PG  G      +G
Sbjct: 2683 HNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LG 2733

Query: 210  EPSIYCTSNDDQVGIWSGPAPQCIIPNKC----TPPN-----------------VENGIL 248
              SI C  N      W    P C I + C    TPPN                  + G +
Sbjct: 2734 PASIECLPNG--TWSWRNERPYCQIIS-CGELPTPPNGNKIGTQTSYGSTAIFTCDLGFM 2790

Query: 249  V----------------SDNRSL-------------------FSLNEVVEFRCQPGFVMK 273
            +                S+ R L                   +   + V ++C PGF + 
Sbjct: 2791 LVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLI 2850

Query: 274  GPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 332
            G     CQ  + W  +LPSC  V C  P   ++  RT  +  NF+    V +SC  GY +
Sbjct: 2851 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLM 2907

Query: 333  RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEG 389
            +G    +C     WS   P C+V +C D  G   N +    +   N   G  V + C+ G
Sbjct: 2908 QGPTKAQCQANRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPG 2966

Query: 390  FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYT 449
            + L GSS   C   G    W+  +P C  I C  P V PN   +G   E + FG TV+Y+
Sbjct: 2967 YFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYS 3020

Query: 450  CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKL 504
            C           L+G+S+  C    Q NG WS   P C     G  G    P H      
Sbjct: 3021 CT------GKRSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH------ 3064

Query: 505  KTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
                  S+F   ++++Y C   Y  +G     TCL N  W+  +  CK   C  P    N
Sbjct: 3065 -GSRQESNFRTKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTAN 3122

Query: 563  GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTI 622
            G V  I      S + YSC  G+ L G S  +C  +G    WS   P C  I CG P   
Sbjct: 3123 GKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIP 3179

Query: 623  ANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 682
            ANG       +++  G  V+Y C PG       EL G     CT N    G WSG  P C
Sbjct: 3180 ANG---LRYGDDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTC 3228

Query: 683  IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 742
                  TPP + NG L   N   F     + + C PG+ +  P  + C     W  E+P 
Sbjct: 3229 RAVTCPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3285

Query: 743  C-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAP 801
            C  + C  P       + +R+  +F    EV +SC   + L G+++  C   G WS ++P
Sbjct: 3286 CLPKFCGDPG---IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3342

Query: 802  TC---EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
             C      SC++  G   +G        Q+G+ V F C +G  L+GS+   C+    +  
Sbjct: 3343 HCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLT 3398

Query: 859  WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
            W+   P C    C  P    +    G  +++   G T+ YTC P       F L G +  
Sbjct: 3399 WSGIQPECIPHSCKQPETPAHANVVG--MDLPSHGYTLIYTCQP------GFFLAGGTEH 3450

Query: 919  R-CTSDPQGNGVWSSPAPRC 937
            R C SD      W+   P C
Sbjct: 3451 RVCRSD----NTWTGKVPIC 3466



 Score =  220 bits (561), Expect = 1e-56
 Identities = 167/559 (29%), Positives = 241/559 (43%), Gaps = 53/559 (9%)

Query: 63   FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGI 121
            F  GT + Y+C PGY     S+ IC  N  W      C    C +P  P N ++   K  
Sbjct: 2953 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-Y 3011

Query: 122  QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD---RIPCGLPPTITNGDFI 178
             FGS + YSCT    L+G SS TC ++G    W    P C       CG P T  +G   
Sbjct: 3012 TFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG--- 3065

Query: 179  STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 238
            S    NF   S V Y C+ G      + L G     C +N    G W+G  P+C      
Sbjct: 3066 SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAVQCG 3115

Query: 239  TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
             P    NG +   + + FS +  V + C  G+++ GP   +C A   W   LP+C+ +  
Sbjct: 3116 NPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3173

Query: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY--DLRGAASMRCTPQGDWSPAAPTCEVK 356
              P +       R  D++  GQ V Y C+PGY  +L G+    CT  G WS   PTC   
Sbjct: 3174 GDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3231

Query: 357  SCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 416
            +C     Q+ NGR L   N   G  + ++C  G++L   +   CV  G    W+  VP C
Sbjct: 3232 TCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG---TWSGEVPQC 3286

Query: 417  EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 476
               FC  P +   G+  GK    F +   V+++C+        F L+G ST  C    Q 
Sbjct: 3287 LPKFCGDPGIPAQGKREGKS---FIYQSEVSFSCN------FPFILVGSSTRIC----QA 3333

Query: 477  NGVWSSPAPRC--GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSI 534
            +G WS  +P C       C+ P      +  +Q N   F +G+ +++ C+  +  +  + 
Sbjct: 3334 DGTWSGSSPHCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTT 3390

Query: 535  -TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSA 593
             TCL +L WS  +  C   SCK P  P +  V  +     G  + Y+C  G  L G +  
Sbjct: 3391 RTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEH 3450

Query: 594  ECILSGNAAHWSTKPPICQ 612
                S N   W+ K PIC+
Sbjct: 3451 RVCRSDNT--WTGKVPICE 3467



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 99/409 (24%)

Query: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965
            C  P EP NG   I +D   GSTV +SC+E + L G+ S TC  ++     W    P+C+
Sbjct: 486  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 1966 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 2000
            + +C      P  T ++ +F   Y +N       T+ +   V+            Y   T
Sbjct: 545  VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604

Query: 2001 GPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTN--------KCTAPEVEN-AI 2050
              DG ++ +      +   S   D +   SS     + T+        K    E+E  + 
Sbjct: 605  IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 664

Query: 2051 RVPGNRSF-------FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-----SR 2098
              PG   +       F+  +++RF CQ GF ++G  ++ CQ N +W   +P C     S 
Sbjct: 665  GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 724

Query: 2099 VCQPPPEILHGEHTLSHQDNFS--------PGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
               P   +L  ++   + +N +        PG  +  S    +DL           GD S
Sbjct: 725  FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-S 782

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPL--------------------------------- 2177
            PE+P     +  +    L     +L L                                 
Sbjct: 783  PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPIN 842

Query: 2178 ------NLQLGAKVSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVC 2219
                  N QLG+ +S +C+EGF + +G     C+L   K +W+  +P C
Sbjct: 843  ARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 225/1043 (21%), Positives = 355/1043 (34%), Gaps = 219/1043 (20%)

Query: 183  ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP- 241
            +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+C  P  C    
Sbjct: 848  DNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPKCGAP--CGGHF 899

Query: 242  NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
            +  +G+++S     +   SLN       +PG  +K           +++ EL        
Sbjct: 900  SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQTELNYDVLEVH 952

Query: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358
              P++L         +     Q +F S    Y L    + R          + T    SC
Sbjct: 953  DGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 1010

Query: 359  DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418
             D  G  ++GR  +  +  +G+ V F CD G++L       C        W+  +P C+ 
Sbjct: 1011 LD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1065

Query: 419  IFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD-------------LI 463
            + C      P+G     G P E +P      +T D    +G  F+             LI
Sbjct: 1066 L-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1123

Query: 464  GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
             E+        +  G    P    G+ G+ +A   F+          SDF    S+ YE 
Sbjct: 1124 TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SDF----SISYE- 1168

Query: 524  RPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCT 582
                    F+IT  + NL           + C+ P  P  G   +  +  +G  + +SC+
Sbjct: 1169 -------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNFGIGDTLTFSCS 1209

Query: 583  TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR----ENFHYG 638
            +G+RL G S   C L G    WS   P C    CG   T   G  +S N     EN H  
Sbjct: 1210 SGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHE- 1266

Query: 639  SVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695
             + + +   G G     + F L         +  D + I+ G      +    T  ++  
Sbjct: 1267 CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHLLGAFTGASMRG 1317

Query: 696  GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
              L S +  L+     +EF        +G + V          EL  C       P +  
Sbjct: 1318 LTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE-----DPGIPQ 1361

Query: 756  AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMG 813
                  D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+C  +    F G
Sbjct: 1362 FGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1420

Query: 814  QLLNGRVL-----FPVNLQLGAKVDFVCDEG------FQLKGSSASYCVLAGMESLWNSS 862
            +  +GR+L     FP +  L        D G      F    + AS+ +L     +W+  
Sbjct: 1421 E-SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDIL----RVWDGP 1475

Query: 863  VPVCEQIFCPSPPVIPNGRHTGKPLEVFPF------------------------------ 892
                  +   S  +IP G H+   +    F                              
Sbjct: 1476 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1535

Query: 893  -----------GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 937
                       G TV + CDP       ++L GE  I C    +    W    P C    
Sbjct: 1536 NGTRNGDGREPGDTVVFQCDP------GYELQGEERITCI-QVENRYFWQPSPPVCIAPC 1588

Query: 938  -----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW 992
                 G  G   +P+   F      +   D+ I  +  Y     +    FSI    + ++
Sbjct: 1589 GGNLTGSSGFILSPN---FPHPYPHSRDCDWTITVNADYVISLAFIS--FSIEPNYDFLY 1643

Query: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052
                           PD  + ++    D ++  RI  S  T H L   S      +G   
Sbjct: 1644 -----------IYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTGFHL 1691

Query: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112
             +  K     R  C  P  I NG  +     ++  GS VTY C+ G      + L G  +
Sbjct: 1692 EYKAK----LRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYST 1738

Query: 1113 IYCTSNDDQVGIWSGPAPQCIIP 1135
            + C   DD    W+   P C  P
Sbjct: 1739 LTCIMGDDGRPGWNRALPSCHAP 1761



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 196/861 (22%), Positives = 310/861 (36%), Gaps = 172/861 (19%)

Query: 460  FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 519
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 694  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 733

Query: 520  KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 564
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 734  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 789

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPC-GLPPTIA 623
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 790  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 840

Query: 624  NGDFISTNR--ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 841  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 890

Query: 682  CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 737
            C  P  C    +  +G+++S     +   SLN       +PG  +K           +++
Sbjct: 891  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQ 941

Query: 738  PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
             EL          P++L         +     Q +F S    Y L    + R        
Sbjct: 942  TELNYDVLEVHDGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 999

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 857
              + T    SC D  G  ++GR  +  +  +G+ V F CD G++L       C       
Sbjct: 1000 YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNH 1054

Query: 858  LWNSSVPVCEQIFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD---- 911
             W+  +P C+ + C      P+G     G P E +P      +T D    +G  F+    
Sbjct: 1055 WWSHPLPTCDAL-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTF 1112

Query: 912  ---------LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD 962
                     LI E+        +  G    P    G+ G+ +A   F+          SD
Sbjct: 1113 HLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SD 1162

Query: 963  FPIGTSLKYECRPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDI 1021
            F    S+ YE         F+IT  + NL           + C+ P  P  G   +  + 
Sbjct: 1163 F----SISYE--------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNF 1198

Query: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081
             +G  + +SC++G+RL G S   C L G    WS   P C    CG   T   G  +S N
Sbjct: 1199 GIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPN 1256

Query: 1082 R----ENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 1134
                 EN H   + + +   G G     + F L         +  D + I+ G      +
Sbjct: 1257 YPLNYENNHE-CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHL 1306

Query: 1135 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1194
                T  ++    L S +  L+     +EF        +G + V          EL  C 
Sbjct: 1307 LGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE 1355

Query: 1195 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPT 1252
                  P +        D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+
Sbjct: 1356 -----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPS 1409

Query: 1253 CEVKSCDDFMGQLLNGRVLFP 1273
            C  +    F G+  +GR+L P
Sbjct: 1410 CIAECGGRFKGE-SSGRILSP 1429



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 134/603 (22%), Positives = 207/603 (34%), Gaps = 149/603 (24%)

Query: 1606 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPEILHGEHTP 1660
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   +L  ++  
Sbjct: 680  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 739

Query: 1661 SHQDNFS--------PGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP----------- 1701
             + +N +        PG  +  S    +DL           GD SPE+P           
Sbjct: 740  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 797

Query: 1702 ----------RCAVKSCDDFLGQ------------------LPHGRVLFPLNLQLGAKVS 1733
                      R   ++     G+                  +P     F  N QLG+ +S
Sbjct: 798  SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSIS 857

Query: 1734 FVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI-- 1790
             +C+EGF + +G+    C+L+  + +W+  +P C        P    G H   PSG I  
Sbjct: 858  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC------GAPC---GGHFSAPSGVILS 908

Query: 1791 ---PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSV 1841
               P   + S  C      +P     +TF            + H      SP     L  
Sbjct: 909  PGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP-----LLG 963

Query: 1842 RAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1901
                 + P QF F+S     ++F + + T+ N     G+            + + SV  N
Sbjct: 964  SYNGTQVP-QFLFSS-----SNFIYLLFTTDNSRSNNGF-----------KIHYESVTVN 1006

Query: 1902 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961
                SC  P  P +G      D   GSTV++SC+ G+RL       C     N  W    
Sbjct: 1007 --TYSCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPL 1060

Query: 1962 PICEIIS----CEPPPTISN---GDFYSNN-----RTSFHNGTVVTYQCHT-GPDGEQLF 2008
            P C+ +       P  TI +    +FY N+          +G  V +  HT   +    +
Sbjct: 1061 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1120

Query: 2009 ELVGERSIYCTSKDDQVGVWSSPPP--------------RCISTNKCT------------ 2042
             L+ E   +        G  S  PP              R IS    +            
Sbjct: 1121 LLITENGSFTQPLARLTG--SDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178

Query: 2043 -APEVENAIRVPGNRSFFT--LTEIIRFRCQPGFVMVGSHTVQCQTNGR--WGPKLPHCS 2097
              P  +  I   G+R  F   + + + F C  G+ + G+  + C   GR  W   LP C 
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238

Query: 2098 RVC 2100
              C
Sbjct: 1239 AEC 1241



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 203/866 (23%), Positives = 304/866 (35%), Gaps = 179/866 (20%)

Query: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 1419
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 694  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 733

Query: 1420 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 1464
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 734  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 789

Query: 1465 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC-GLPPTIA 1523
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 790  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 840

Query: 1524 NGDFISTNR--ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 841  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 890

Query: 1582 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1637
            C  P  C    +  +G+++S     +   SLN       +PG  +K         LN   
Sbjct: 891  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 948

Query: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697
             E+     +  P     +G   P    + S    + ++ +      G   +H        
Sbjct: 949  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGF-KIHY------- 1000

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS 1757
             E+      SC D  G   HGR  +  +  +G+ VSF CD G+RL   S    +L     
Sbjct: 1001 -ESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1054

Query: 1758 LWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI---------PYGKEISYTCDPHPDRGM 1808
             W++ +P C+        A+  G   G PSG I         P     ++T D    +G+
Sbjct: 1055 WWSHPLPTCD--------ALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1105

Query: 1809 TFNLIGESTIRCTSDPHG------NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1862
             FN     T     D H       NG ++ P  R   S             F +    I+
Sbjct: 1106 QFNF---HTFHL-EDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFIS 1161

Query: 1863 DFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922
            DF      S++YE     F   FS   LE               C  P  P  G   I  
Sbjct: 1162 DF------SISYEG----FNITFSEYNLE--------------PCEDPGIPQYGS-RIGF 1196

Query: 1923 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS 1982
            +   G T+ +SC+ G+RL G+    CL  G  V W    P C +  C    T + G   S
Sbjct: 1197 NFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-VAECGASATNNEGILLS 1254

Query: 1983 -NNRTSFHNGTVVTY--QCHTGPD---GEQLFELV-GERSIYCTSKDDQ---VGVWSSPP 2032
             N   ++ N     Y  Q   G       + F L  G+       KD     +G ++   
Sbjct: 1255 PNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGAS 1314

Query: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPK 2092
             R +     T     N + +  N       E        GF +V +             +
Sbjct: 1315 MRGL-----TLSSTSNQLWLEFNSDTEGTDE--------GFQLVYTSF-----------E 1350

Query: 2093 LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT--PQGDWS 2150
            L HC       P I    + +S Q +F+ G  + Y C P Y L G++ L C    +  W 
Sbjct: 1351 LSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWD 1404

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLP 2176
               P C  +    F G+   GR+L P
Sbjct: 1405 YPLPSCIAECGGRFKGE-SSGRILSP 1429



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 107/455 (23%), Positives = 163/455 (35%), Gaps = 100/455 (21%)

Query: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVIWDNETPICD 162
           C +P +P NG   +      GS +++SC + Y L G+ S TC  I+     W +  P+C 
Sbjct: 486 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 163 RIPC-----GLPPTITNGDF----------------ISTNRE---NFH-YGSVVTY-RCN 196
              C     G   T T+ +F                ++TN+    NF  +   + Y    
Sbjct: 545 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604

Query: 197 PGSGG-----RKVFE-LVGE--PSIYCTSN---------DDQVG-IWSGPAPQCIIPNKC 238
            G GG     R V + L G   P +  + +         D+ VG +      + I    C
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 664

Query: 239 TPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---- 293
             P     GI   D    FS  +V+ F CQ GF + G + + CQ  N+W   +P C    
Sbjct: 665 GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 721

Query: 294 -SRVCQPPPDVLHAERTQRDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQG 344
            S    P   VL  +  +   +N +        PG  +  S    +DL           G
Sbjct: 722 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 780

Query: 345 DWSPAAPTCEVKSCDDFMGQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403
           D SP +P     +  +    L  N  +L         +++F  D     +G + +Y    
Sbjct: 781 D-SPESPILGTFTGAEVPSHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFG 830

Query: 404 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
             E              CP P +  N R  G   + F  G +++  C+            
Sbjct: 831 HNE--------------CPDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQ 868

Query: 464 GESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAP 496
           G  TI C     G  +WS   P+CG    GH  AP
Sbjct: 869 GTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 902



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 137/619 (22%), Positives = 201/619 (32%), Gaps = 134/619 (21%)

Query: 384  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 442
            F C  GF+L G  +  C      + W++++P+C  IF C S    P G         +P 
Sbjct: 688  FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 739

Query: 443  GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
            G   N  C      DP      SF D   ES     +   G+   S  +P  G     + 
Sbjct: 740  GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 796

Query: 496  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 555
            P H         T+ S       L+++      GR F+IT           +      C 
Sbjct: 797  PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 835

Query: 556  TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 614
             P  P+N       + Q+GS I+  C  G  +  G  +  CIL      WS   P C   
Sbjct: 836  DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 893

Query: 615  PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
            PCG   +  +G  +S     ++  S+         PG   +  FE           N D 
Sbjct: 894  PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 948

Query: 672  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731
            + +  GP     +        V    L S +  ++ L      R   GF +      +  
Sbjct: 949  LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 1003

Query: 732  ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791
             +N +          C  P   +H  R   D   FS G  V +SC+ GY L     + C 
Sbjct: 1004 TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1051

Query: 792  PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 841
                WS   PTC+     D  G   +G +L       +P +L     VD    +G Q   
Sbjct: 1052 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1109

Query: 842  --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 870
                                      L GS     + AG+   + + +            
Sbjct: 1110 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1169

Query: 871  ------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
                        C  P +   G   G     F  G T+ ++C       + + L G S I
Sbjct: 1170 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1220

Query: 919  RCTSDPQGNGVWSSPAPRC 937
             C     G  VWS+P PRC
Sbjct: 1221 ICLGG--GRRVWSAPLPRC 1237



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 143/626 (22%), Positives = 213/626 (34%), Gaps = 125/626 (19%)

Query: 553  SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 611
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S N A W    PIC
Sbjct: 177  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 612  Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 667
            +    CG     ++G   S +  N +H  +  T+     PG     +F            
Sbjct: 236  RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 290

Query: 668  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE-------FRCQPGF 720
              D + I     P   +     PP       +  N++   L+ V +       F      
Sbjct: 291  KYDYLEIEGSEPPTIWLSGMNIPPP------IISNKNWLRLHFVTDSNHRYRGFSAPYQG 344

Query: 721  VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780
                        L +          V   P DV  +  T       S  Q V  +     
Sbjct: 345  SSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVT----- 399

Query: 781  DLRGAASMRCTPQGDWSP-AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEG 839
             LR +     T +   SP  A T   +       Q+   + L  V  ++   +DF    G
Sbjct: 400  SLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFK-SRG 458

Query: 840  FQL---KGSSASYCVL--AGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 894
            F+L   K +S  + +L   G+++  N          CP P    NG+  G     F  G 
Sbjct: 459  FKLFPGKDNSNKFSILNEGGIKTASN---------LCPDPGEPENGKRIGSD---FSLGS 506

Query: 895  TVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL---GHCQAPDHFLF 951
            TV ++CD        + L G  +I C    +    WS   P C +     + Q P     
Sbjct: 507  TVQFSCD------EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 560

Query: 952  A---KLKTQTNASDFPIGTSLKYECRPEYYGRPF-------SITCLDNLVWSSPKDVCKR 1001
            +     +  +NA    + T++      +     F       ++T  D      P+ V + 
Sbjct: 561  SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQV 620

Query: 1002 KSCKTPPDPVNGM-----VHVITDIQVGS---RINYSCTTGHRLIGHSSAECILSGNAAH 1053
             +    PD +  M     +H+ TD  VGS   ++NY                        
Sbjct: 621  LTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK----------------------- 657

Query: 1054 WSTKPPICQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109
                    ++  CG P T    I  GD  S NR+      V+ + C  G      FEL+G
Sbjct: 658  ------EIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIG 698

Query: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIP 1135
            E SI C  N+     WS   P CI P
Sbjct: 699  EKSIVCQENNQ----WSANIPICIFP 720



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 136/619 (21%), Positives = 200/619 (32%), Gaps = 134/619 (21%)

Query: 834  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 892
            F C  GF+L G  +  C      + W++++P+C  IF C S    P G         +P 
Sbjct: 688  FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 739

Query: 893  GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
            G   N  C      DP      SF D   ES     +   G+   S  +P  G     + 
Sbjct: 740  GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 796

Query: 946  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 1005
            P H         T+ S       L+++      GR F+IT           +      C 
Sbjct: 797  PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 835

Query: 1006 TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 1064
             P  P+N       + Q+GS I+  C  G  +  G  +  CIL      WS   P C   
Sbjct: 836  DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 893

Query: 1065 PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
            PCG   +  +G  +S     ++  S+         PG   +  FE           N D 
Sbjct: 894  PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 948

Query: 1122 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 1181
            + +  GP     +        V    L S +  ++ L      R   GF +      +  
Sbjct: 949  LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 1003

Query: 1182 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 1241
             +N +          C  P   +H  R   D   FS G  V +SC+ GY L     + C 
Sbjct: 1004 TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1051

Query: 1242 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 1291
                WS   PTC+     D  G   +G +L       +P +L     VD    +G Q   
Sbjct: 1052 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1109

Query: 1292 --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 1320
                                      L GS     + AG+   + + +            
Sbjct: 1110 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1169

Query: 1321 ------------CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTI 1368
                        C  P +   G   G     F  G  + ++C       + + L G S I
Sbjct: 1170 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1220

Query: 1369 RCTSDPQGNGVWSSPAPRC 1387
             C     G  VWS+P PRC
Sbjct: 1221 ICLGG--GRRVWSAPLPRC 1237



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 132/647 (20%), Positives = 223/647 (34%), Gaps = 127/647 (19%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G     +G   GS I Y C  GY L GSS   C+ +G+   WD   P C  
Sbjct: 1354 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIA 1412

Query: 164  IPCGLPPTITNGDFISTNRENFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTS 217
               G     ++G  +S     F Y +    RC      +PG+     F      +    +
Sbjct: 1413 ECGGRFKGESSGRILSPGYP-FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEA 1464

Query: 218  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
            + D + +W GP    ++  + +   +  GI  + N  + ++    +F     ++ K    
Sbjct: 1465 SHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFA 1517

Query: 278  VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS 337
            ++  +         S +  C+ P   ++  R   + D   PG  V + C+PGY+L+G   
Sbjct: 1518 IQFSS---------SVATACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEER 1565

Query: 338  MRCTPQGD---WSPAAPTCEVKSCDDFMGQLLNGRVLFP--------------------- 373
            + C    +   W P+ P C      +  G   +G +L P                     
Sbjct: 1566 ITCIQVENRYFWQPSPPVCIAPCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNAD 1623

Query: 374  -------VNLQLGAKVDFVC-----DEGFQLKGSSASYCVLAGMESLWNS---------- 411
                   ++  +    DF+      D    L GS     +   +ES  N+          
Sbjct: 1624 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1683

Query: 412  ----------SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
                         + E  F P    I NG   G     +  G TV Y CD        + 
Sbjct: 1684 VSYTGFHLEYKAKLRESCFDPGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYV 1732

Query: 462  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            L G ST+ C     G   W+   P       C AP        +    + ++P   S+ +
Sbjct: 1733 LQGYSTLTCIMGDDGRPGWNRALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGH 1786

Query: 522  ECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
             C       P         V+  +S  DV +       P   + ++  ++    G  +  
Sbjct: 1787 NC-VYSIAVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPL 1842

Query: 580  SCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYG 638
            S  +G+++    ++   ++    H+  +  P      C   P    G  I      F  G
Sbjct: 1843 S--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVG 1897

Query: 639  SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            S V + CNPG      + L G  +I C +  + +  W+   P CI+P
Sbjct: 1898 SSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1938



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 104/479 (21%), Positives = 156/479 (32%), Gaps = 110/479 (22%)

Query: 69   LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128
            L ++     SGR F+I            +      C +P  P+N         Q GS I 
Sbjct: 809  LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINAR-RFGDNFQLGSSIS 857

Query: 129  YSCTKGY-RLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHY 187
              C +G+ +  G+ + TCI+    V+W    P C   PCG   +  +G  +S     ++ 
Sbjct: 858  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG-APCGGHFSAPSGVILSPGWPGYYK 916

Query: 188  GSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP---APQCIIPNKCTPP 241
             S+         PG   +  FE           N D + +  GP   +P     N    P
Sbjct: 917  DSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVP 971

Query: 242  NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
                  L S +  ++ L      R   GF +      +   +N +          C  P 
Sbjct: 972  Q----FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 1014

Query: 302  DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
              +H  R   D   FS G  V +SC+ GY L     + C     WS   PTC+     D 
Sbjct: 1015 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1071

Query: 362  MGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ----------------------- 391
             G   +G +L       +P +L     VD    +G Q                       
Sbjct: 1072 RGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1129

Query: 392  ------LKGSSASYCVLAGMESLWNSSVPVCEQIF-----------------CPSPPVIP 428
                  L GS     + AG+   + + +                        C  P +  
Sbjct: 1130 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1189

Query: 429  NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
             G   G     F  G T+ ++C       + + L G S I C     G  VWS+P PRC
Sbjct: 1190 YGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEIICLGG--GRRVWSAPLPRC 1237



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 139/652 (21%), Positives = 216/652 (33%), Gaps = 142/652 (21%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G   +      G  + +SC+ GYRL G+S   C + G   +W    P C  
Sbjct: 1182 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC-V 1238

Query: 164  IPCGLPPTITNGDFIS----TNRENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCT 216
              CG   T   G  +S     N EN H   + + +   G G     + F L         
Sbjct: 1239 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHL--------- 1288

Query: 217  SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 276
            +  D + I+ G      +    T  ++    L S +  L+     +EF        +G +
Sbjct: 1289 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQ 1343

Query: 277  RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 336
             V          EL  C       P +        D+ +F+ G  + Y C PGY L G++
Sbjct: 1344 LVYTSF------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSS 1391

Query: 337  SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-----FPVNLQLGAKVDFVCDEG 389
             ++C    +  W    P+C  +    F G+  +GR+L     FP +  L        D G
Sbjct: 1392 LLKCMTGERRAWDYPLPSCIAECGGRFKGE-SSGRILSPGYPFPYDNNLRCMWMIEVDPG 1450

Query: 390  ------FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF- 442
                  F    + AS+ +L     +W+        +   S  +IP G H+   +    F 
Sbjct: 1451 NIVSLQFLAFDTEASHDIL----RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFD 1506

Query: 443  ----------------------------------------GKTVNYTCDPHPDRGTSFDL 462
                                                    G TV + CDP       ++L
Sbjct: 1507 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP------GYEL 1560

Query: 463  IGESTIRCTSDPQGNGVWSSPAPRC---------GILGHCQAPDHFLFAKLKTQTNASDF 513
             GE  I C    +    W    P C         G  G   +P+   F      +   D+
Sbjct: 1561 QGEERITCI-QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN---FPHPYPHSRDCDW 1616

Query: 514  PIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573
             I  +  Y     +    FSI    + ++               PD  + ++    D ++
Sbjct: 1617 TITVNADYVISLAFIS--FSIEPNYDFLY-----------IYDGPDSNSPLIGSFQDSKL 1663

Query: 574  GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633
              RI  S  T H L   S      +G    +  K     R  C  P  I NG  +     
Sbjct: 1664 PERIESSSNTMH-LAFRSDGSVSYTGFHLEYKAK----LRESCFDPGNIMNGTRLGM--- 1715

Query: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            ++  GS VTY C+ G      + L G  ++ C   DD    W+   P C  P
Sbjct: 1716 DYKLGSTVTYYCDAG------YVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1761



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 706 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 760
           FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 680 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 739

Query: 761 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 812
              +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 740 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 797

Query: 813 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871
             L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 798 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 834

Query: 872 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
           P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 835 PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 885

Query: 932 SPAPRCGIL--GHCQAP 946
              P+CG    GH  AP
Sbjct: 886 GLIPKCGAPCGGHFSAP 902



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 1210
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 680  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 739

Query: 1211 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 1262
               +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 740  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 797

Query: 1263 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 1321
              L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 798  SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 834

Query: 1322 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
            P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 835  PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 885

Query: 1382 SPAPRCGIL--GHCQAP 1396
               P+CG    GH  AP
Sbjct: 886  GLIPKCGAPCGGHFSAP 902



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 184/870 (21%), Positives = 288/870 (33%), Gaps = 206/870 (23%)

Query: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 1333
            +  LG+ V F CDE + L+G+ +  C  +A + + W+   PVC+   C S    P+G  T
Sbjct: 501  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 560

Query: 1334 GKPLEVFPFGKAVNYTC----------DPHPDRGTSFDL-IGESTIRCTSDPQGNGVWSS 1382
                  FPF    N  C                   FDL IG  T+         G    
Sbjct: 561  SPN---FPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGD----GGEVGD 613

Query: 1383 PAPRCGILGHCQAPDHFLFAK----LKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438
            P     +L     PD  +       L  QT+ S   +G  + Y                 
Sbjct: 614  PRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY----------------- 656

Query: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 1498
                   K++ +++SC  P  P+ G +           + + C  G  LIG  S  C   
Sbjct: 657  -------KEI-EKESCGDPGTPLYG-IREGDGFSNRDVLRFECQFGFELIGEKSIVC--- 704

Query: 1499 GNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELV 1558
                 WS   PIC   PC    T   G  +S +           Y    G+    ++ ++
Sbjct: 705  QENNQWSANIPIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTII 752

Query: 1559 GEPS--IYCTSND-------DQVGIWSGPAPQCII------------------------- 1584
             +P   I+ + ND       D + +  G +P+  I                         
Sbjct: 753  SDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQ 812

Query: 1585 ------------------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKG 1624
                               N+C  P +  N     DN   F L   +   C+ GF+  +G
Sbjct: 813  ADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQG 869

Query: 1625 PRRVKCQALN---KWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681
               + C  ++    W   +P C   C        G H       FS    V  S  PG+ 
Sbjct: 870  TETITCILMDGKVMWSGLIPKCGAPC--------GGH-------FSAPSGVILS--PGWP 912

Query: 1682 LRGAASLHCTPQGDWSPEA-PRCAVK-SCDDFLGQLPHG--------RVLFPLNLQLGAK 1731
                 SL+C    +W  EA P  ++K + + F  +L +          +L PL   LG+ 
Sbjct: 913  GYYKDSLNC----EWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPL---LGSY 965

Query: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPV------CEHIFCPNPPAILNGRHTGT 1785
                  + F    S+  + +     S  NN   +           C +P   ++GR  G 
Sbjct: 966  NGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG- 1023

Query: 1786 PSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGH 1845
               D   G  +S++CD        + L  E  + C      N  WS P P C+ ++  G 
Sbjct: 1024 --HDFSIGSTVSFSCD------SGYRLSHEEPLLCEK----NHWWSHPLPTCD-ALCGGD 1070

Query: 1846 CKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRK 1905
             + P      SP  P  +F +P   +  +     + GK    +           D     
Sbjct: 1071 VRGPSG-TILSPGYP--EF-YPNSLNCTWTVDVTH-GKGVQFN-FHTFHLEDHHDYLLIT 1124

Query: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFR--LIGSPSTTCLVSGNNVTWDKKAPI 1963
              G   +P   +    T +    T+N      FR  L      +    G N+T+ +    
Sbjct: 1125 ENGSFTQPLARL----TGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---- 1176

Query: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 2023
              +  CE P     G     N   F  G  +T+ C +G      + L G   I C     
Sbjct: 1177 YNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSCSSG------YRLEGTSEIICLGGGR 1227

Query: 2024 QVGVWSSPPPRCISTNKCTAPEVENAIRVP 2053
            +  VWS+P PRC++    +A   E  +  P
Sbjct: 1228 R--VWSAPLPRCVAECGASATNNEGILLSP 1255



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 2/61 (3%)

Query: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSTKPPIC 1511
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S NTA W    PIC
Sbjct: 177  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 1512 Q 1512
            +
Sbjct: 236  R 236



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 70/277 (25%), Positives = 100/277 (36%), Gaps = 34/277 (12%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSTKPPICQ 1512
            C  P +P NG   + +D  +GS + +SC   + L G  S  C  ++   A WS   P+C+
Sbjct: 486  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNLGSRGRKVFELVGEPSIYCT 1566
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 545  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 602

Query: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 603  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 652

Query: 1627 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
                  +N  E E  SC     P   I  G       D FS    + + C+ G++L G  
Sbjct: 653  -----KVNYKEIEKESCGDPGTPLYGIREG-------DGFSNRDVLRFECQFGFELIGEK 700

Query: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
            S+ C     WS   P C      +F    P G VL P
Sbjct: 701  SIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSP 735



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 140/645 (21%), Positives = 212/645 (32%), Gaps = 136/645 (21%)

Query: 1810 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG 1869
            F LIGE +I C      N  WS+  P C              FP  S      +F  P+G
Sbjct: 694  FELIGEKSIVCQE----NNQWSANIPICI-------------FPCLS------NFTAPMG 730

Query: 1870 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRR-------------------KSCGPP 1910
            T L+ +   GY   +       N +W+ + D   R                   K    P
Sbjct: 731  TVLSPDYPEGYGNNL-------NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 783

Query: 1911 PEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1970
              P  G     T  +  S +  S +   RL      +    G N+T++          C 
Sbjct: 784  ESPILGTF---TGAEVPSHLT-SNSHILRLEFQADHSMSGRGFNITYNTFGHN----ECP 835

Query: 1971 PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSS 2030
             P    N   + +N   F  G+ ++  C  G       +  G  +I C   D +V +WS 
Sbjct: 836  DPGIPINARRFGDN---FQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSG 886

Query: 2031 PPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG 2090
              P+C +            I  PG   ++  +      C+        H+++  T  R+ 
Sbjct: 887  LIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS----LNCEWVIEAEPGHSIKI-TFERFQ 941

Query: 2091 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
             +L +        P +L     L   +     Q +F S    Y L    +          
Sbjct: 942  TELNYDVLEVHDGPNLL--SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 999

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 2210
             E+      SC D  G   HGR     +  +G+ VSF CD G+RL   S    +L     
Sbjct: 1000 YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1054

Query: 2211 LWNSSVPVCE------------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT-HP 2257
             W+  +P C+             I  P  P         T   D+ +GK + +   T H 
Sbjct: 1055 WWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL 1114

Query: 2258 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL- 2316
            +    + LI E           NG ++ P  R           PP I  G Y      L 
Sbjct: 1115 EDHHDYLLITE-----------NGSFTQPLARL-----TGSDLPPTINAGLYGNFRAQLR 1158

Query: 2317 YLPGMTISYICDPGYLLVGKGFIF--CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEM 2374
            ++   +ISY    G+ +    +    C D GI      Y   +  +F +           
Sbjct: 1159 FISDFSISY---EGFNITFSEYNLEPCEDPGI----PQYGSRIGFNFGI----------- 1200

Query: 2375 KKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTS 2417
                  GD +T  C  GY LEG+    C    R  W  PL +C +
Sbjct: 1201 ------GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1239



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%)

Query: 554 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 612
           C  P +P NG   + +D  +GS + +SC   + L G  S  C       A WS   P+C+
Sbjct: 486 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 613 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 666
              CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 545 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 602

Query: 667 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 726
                 G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 652

Query: 727 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 786
                 +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 653 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 700

Query: 787 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823
           S+ C     WS   P C      +F   +  G VL P
Sbjct: 701 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 735



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%)

Query: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 1062
            C  P +P NG   + +D  +GS + +SC   + L G  S  C       A WS   P+C+
Sbjct: 486  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544

Query: 1063 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 1116
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 545  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 602

Query: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 603  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 652

Query: 1177 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 1236
                  +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 653  -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 700

Query: 1237 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 1273
            S+ C     WS   P C      +F   +  G VL P
Sbjct: 701  SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 735



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 2/66 (3%)

Query: 97  DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWD 155
           +  +  SC NP  P  G+++  +    G +I+YSC  GY L G    TCI  S +T  WD
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229

Query: 156 NETPIC 161
              PIC
Sbjct: 230 FPVPIC 235



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)

Query: 1900 DNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWD 1958
            +  +  SCG P  P  G+++  T    G  + YSC  G+ L G P  TC+  S N  +WD
Sbjct: 171  EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229

Query: 1959 KKAPIC 1964
               PIC
Sbjct: 230  FPVPIC 235



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 103  SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
            +CR+P  P+NG  +   G + G  + + C  GY L G    TCI   +   W    P+C 
Sbjct: 1527 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC- 1584

Query: 163  RIPCGLPPTITNGDFISTN 181
              PCG   T ++G  +S N
Sbjct: 1585 IAPCGGNLTGSSGFILSPN 1603



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 83/385 (21%), Positives = 138/385 (35%), Gaps = 90/385 (23%)

Query: 1866 FPVGTSLNYECRPGYFGKMF-SISCLENLV----WSSVEDNCRRK-SCGPPPEPFNGMVH 1919
            F VG  + Y C  GY       ++C+ N V    W      CR + +CG      +G++ 
Sbjct: 194  FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII- 252

Query: 1920 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP------- 1972
              +   F +  + + +  + ++  P  T  +   +   ++K    EI   EPP       
Sbjct: 253  --SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 310

Query: 1973 ----PTISNGDFY-------SNNR-----TSFHNGTVVTYQCHTGPDGEQLFELVGERSI 2016
                P ISN ++        SN+R       +   + +T+   TG   E      G  ++
Sbjct: 311  NIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAV 370

Query: 2017 YCT-----------------SKDDQVGVWS---------------SPPPRCISTNKCTAP 2044
              T                 S++ +V V S               SP P   +  + T  
Sbjct: 371  ASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHP---ADTQSTRR 427

Query: 2045 EVENAIRVPGNRSFFTLTEIIR---------FRCQPGFVMVGSHTVQCQTNGRWGPKLPH 2095
               +A ++   +    +T  ++         F+  PG     S+       G     +  
Sbjct: 428  RPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPG--KDNSNKFSILNEGG----IKT 481

Query: 2096 CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD----WSP 2151
             S +C  P E  +G+   S   +FS G  V +SC+  Y L+GA S+ C    +    WS 
Sbjct: 482  ASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 538

Query: 2152 EAPRCTVKSCDDFLGQLPHGRVLLP 2176
              P C VK+C   L Q P G    P
Sbjct: 539  HRPVCKVKTCGSNL-QGPSGTFTSP 562



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 8/91 (8%)

Query: 1637 EPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD- 1695
            E  + + S +C  P E  +G+   S   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 476  EGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 532

Query: 1696 ---WSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
               WS   P C VK+C   L Q P G    P
Sbjct: 533  FAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 562



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%)

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 345
           E  + + S +C   PD    E  +R   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 476 EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 532

Query: 346 ---WSPAAPTCEVKSC 358
              WS   P C+VK+C
Sbjct: 533 FAAWSDHRPVCKVKTC 548



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%)

Query: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 1245
            E  + + S +C   PD    E  +R   +FS G  V +SC+  Y L+GA S+ C    + 
Sbjct: 476  EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 532

Query: 1246 ---WSPAAPTCEVKSC 1258
               WS   P C+VK+C
Sbjct: 533  FAAWSDHRPVCKVKTC 548



 Score = 38.9 bits (89), Expect = 0.064
 Identities = 146/721 (20%), Positives = 228/721 (31%), Gaps = 238/721 (33%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQ--IKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
            ++SC +P  P+ G   + +G  F ++  +++ C  G+ LIG  S  C  +     W    
Sbjct: 661  KESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ---WSANI 714

Query: 159  PICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCT 216
            PIC   PC    T   G  +S +           Y    G+    ++ ++ +P   I+ +
Sbjct: 715  PIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTIISDPGSRIHLS 762

Query: 217  SND-------DQVGIWSGPAPQCII----------------------------------- 234
             ND       D + +  G +P+  I                                   
Sbjct: 763  FNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 822

Query: 235  --------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPRRVKCQALN 284
                     N+C  P +  N     DN   F L   +   C+ GF+  +G   + C  ++
Sbjct: 823  NITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMD 879

Query: 285  ---KWEPELPSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFY----SCEPGYDLR 333
                W   +P C   C      P  V+            SPG   +Y    +CE   +  
Sbjct: 880  GKVMWSGLIPKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDSLNCEWVIEAE 928

Query: 334  GAASMRCT-PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-----CD 387
               S++ T  +          EV    + +  LL       V   L +  +F+      D
Sbjct: 929  PGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTD 988

Query: 388  EGFQLKGSSASY-CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTV 446
                  G    Y  V     S  +  +PV             +GR  G     F  G TV
Sbjct: 989  NSRSNNGFKIHYESVTVNTYSCLDPGIPV-------------HGRRYGHD---FSIGSTV 1032

Query: 447  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKL 504
            +++CD      + + L  E  + C    + N  WS P P C  L  G  + P        
Sbjct: 1033 SFSCD------SGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVRGPS------- 1075

Query: 505  KTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 564
                       GT L     PE+Y  P S+ C     W+                     
Sbjct: 1076 -----------GTILS-PGYPEFY--PNSLNC----TWT--------------------- 1096

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN 624
                 D+  G  + ++  T H    H       +G     S   P+ +     LPPTI  
Sbjct: 1097 ----VDVTHGKGVQFNFHTFHLEDHHDYLLITENG-----SFTQPLARLTGSDLPPTINA 1147

Query: 625  G---------DFIST-----------------------------NRENFHY--GSVVTYR 644
            G          FIS                              +R  F++  G  +T+ 
Sbjct: 1148 GLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFS 1207

Query: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRS 704
            C+ G      + L G   I C     +V  WS P P+C+     +  N E GIL+S N  
Sbjct: 1208 CSSG------YRLEGTSEIICLGGGRRV--WSAPLPRCVAECGASATNNE-GILLSPNYP 1258

Query: 705  L 705
            L
Sbjct: 1259 L 1259



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 7/66 (10%)

Query: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTD----QGIWSQLDHY 2353
            CP P + +NG  IG   SL   G T+ + CD  Y+L G   I C         WS     
Sbjct: 486  CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542

Query: 2354 CKEVNC 2359
            CK   C
Sbjct: 543  CKVKTC 548



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 19/113 (16%)

Query: 1539 SVVTYRC----NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1594
            +VVT+R     +  SRG K+F      + +   N+  +   S   P         P   E
Sbjct: 442  AVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPD--------PGEPE 493

Query: 1595 NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1643
            NG  +  +   FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 494  NGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543



 Score = 35.0 bits (79), Expect = 0.92
 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%)

Query: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
           ++  PG      F ++ E  I   SN              + P+   P   ENG  +  +
Sbjct: 459 FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 501

Query: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 293
              FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 502 ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543



 Score = 35.0 bits (79), Expect = 0.92
 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%)

Query: 1093 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 1152
            ++  PG      F ++ E  I   SN              + P+   P   ENG  +  +
Sbjct: 459  FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 501

Query: 1153 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1193
               FSL   V+F C   +V++G + + CQ + +    W    P C
Sbjct: 502  ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 2178 NLQLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC 2224
            +  LG+ V F CDE + L+G  +  C  +A + A W+   PVC+   C
Sbjct: 501  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 548



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 2378 YHYGDYVTLKCEDGYTLEGSPWSQCQADD--RWDPPLAKCTSRTHDAL 2423
            Y  GD V+ +C+ GY+L+G     C      RW+ P+  C ++   A+
Sbjct: 2068 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2115



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 343
           E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 344 -GDWSPAAPTCEVKSCDDFMGQLLNG 368
              W    P C     +D  G  + G
Sbjct: 225 TASWDFPVPICR---AEDACGGTMRG 247



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 793
           E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 794 -GDWSPAAPTCEVKSCDDFMGQLLNG 818
              W    P C     +D  G  + G
Sbjct: 225 TASWDFPVPICR---AEDACGGTMRG 247



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%)

Query: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 1243
            E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172  ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 1244 -GDWSPAAPTCEVKSCDDFMGQLLNG 1268
               W    P C     +D  G  + G
Sbjct: 225  TASWDFPVPICR---AEDACGGTMRG 247



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
           Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 672 VGIWSGPAPQCIIPNKC 688
              W  P P C   + C
Sbjct: 225 TASWDFPVPICRAEDAC 241



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 1122 VGIWSGPAPQCIIPNKC 1138
               W  P P C   + C
Sbjct: 225  TASWDFPVPICRAEDAC 241



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 1572 VGIWSGPAPQCIIPNKC 1588
               W  P P C   + C
Sbjct: 225  TASWDFPVPICRAEDAC 241



 Score = 32.3 bits (72), Expect = 6.0
 Identities = 20/73 (27%), Positives = 25/73 (34%), Gaps = 9/73 (12%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           CG P     G    T    F  G  + Y C  G      + L G P + C +N      W
Sbjct: 178 CGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVNTASW 228

Query: 226 SGPAPQCIIPNKC 238
             P P C   + C
Sbjct: 229 DFPVPICRAEDAC 241


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  397 bits (1020), Expect = e-110
 Identities = 475/1883 (25%), Positives = 692/1883 (36%), Gaps = 356/1883 (18%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159
            R+SC +P + +NG   +    + GS + Y C  GY L G S+ TCI+  D    W+   P
Sbjct: 1594 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652

Query: 160  ICDRIPCGLPPTITNGDFISTNR-ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
             C   PCG   T + G  +S N  +N+  G    + C       K F + G+   + TS 
Sbjct: 1653 SC-HAPCGSRSTGSEGTVLSPNYPKNYSVG----HNCVYSIAVPKEFVVFGQFVFFQTSL 1707

Query: 219  DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
             D V ++ GP  Q  + +  +  +    + +S    +      + F        KG   V
Sbjct: 1708 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKGFHFV 1762

Query: 279  KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338
              QA+ +       CS V +P          +R  + F+ G  V + C PGY L G+ ++
Sbjct: 1763 Y-QAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAI 1812

Query: 339  RC----TPQGDWSPAAPTCEVKSCDDFM----GQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
            RC         W+ + PTC +  C   +    G +L+     P +  L         EG 
Sbjct: 1813 RCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGA 1871

Query: 391  QLKGSSASYCVLAGMESL-----------------------------------WNSSVPV 415
             ++    S+      +SL                                   + S + V
Sbjct: 1872 GIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISV 1931

Query: 416  CEQIF-----------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464
                F           CP P    +G   G   + +  G  V++ CD        + L G
Sbjct: 1932 SAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCD------QGYSLQG 1982

Query: 465  ESTIRCTSDPQGNGVWSSPAPRC------------GILGHCQAPD--------------- 497
             S I C   P     W+ P P C            G++     P                
Sbjct: 1983 HSHITCMPGPVRR--WNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2040

Query: 498  -----HFLFAKLKTQT-------NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSP 545
                 H  F    T+T        +      T +     P+     FS T   +L + S 
Sbjct: 2041 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD 2100

Query: 546  KDVCKR-----------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
                K+           +SC  P    NG V +  D  VG  I++ C  G+ LIG+S+  
Sbjct: 2101 YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALT 2159

Query: 595  CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGG 651
            C L G + +W+   P C+ + CG   T  NG   S    + +      +   R  PG+G 
Sbjct: 2160 C-LHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2217

Query: 652  RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 711
               F ++    IY     D + +W GP            P +      +   S++S +  
Sbjct: 2218 YINFTVLQTEPIY-----DFITVWDGPDQ--------NSPQIGQFSGNTALESVYSTSNQ 2264

Query: 712  VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771
            +  +    F   G   +   A            RVCQPPP V +AE    D D F  G  
Sbjct: 2265 ILIKFHSDFTTSGFFVLSYHAYQ---------LRVCQPPPPVPNAEILTED-DEFEIGDI 2314

Query: 772  VFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP------ 823
            + Y C PG+ L G A + C    +     A P C+V    + +     G +L P      
Sbjct: 2315 IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSY 2374

Query: 824  VNLQLGAKVDFVCDEGFQL-------------------KGSSASYCVLAGMESLWNSSVP 864
             NLQ+ A      ++G+ +                    G +    VL  +   ++S+  
Sbjct: 2375 PNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2433

Query: 865  VCEQ-------------------------IFCPSPPVIPNG---RHTGKPLEVFPFGKTV 896
            +                             +C +P   P+G     TG  L        V
Sbjct: 2434 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL-----NSVV 2488

Query: 897  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 956
             + C    DRG  F L+G+S+  C     G   W +P P C  +  C  P        K 
Sbjct: 2489 RWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KA 2533

Query: 957  QTN----ASDFPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTP 1007
             TN     +D+ +GT + Y C   Y      +T   C  +  WS+      C   SC   
Sbjct: 2534 PTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGEL 2593

Query: 1008 PDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG 1067
            P P NG   + T    GS   ++C  G  L+G +  EC+ SG    WS     C    CG
Sbjct: 2594 PTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCG 2649

Query: 1068 LPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 1127
            +P  I NG  I    EN+ Y   V Y+CNPG      F L+G     C  + +    WSG
Sbjct: 2650 IPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSG 2696

Query: 1128 PAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1187
              P C +P  C  P   + I    + + F+ N+VV F C  G++M+GP + +CQA  +W 
Sbjct: 2697 QLPSC-VPVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWS 2753

Query: 1188 PELPSCSRV-CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 1245
               P C  V C  P    +++R  + +  NF+ G  VFY C PGY L G++ + C P G 
Sbjct: 2754 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ 2813

Query: 1246 WSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            W    P C +  C      +    VL       G+ V + C     L G S+  C L G 
Sbjct: 2814 WDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH 2871

Query: 1306 ESLWNSSVPVC--EQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 1363
               W+ S P C  +       P  P   H  +    F     V Y CD      T + L 
Sbjct: 2872 ---WSGSQPHCSGDATGTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILH 2920

Query: 1364 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTS 1418
            G     C +    NG W+   P C  +  C  P         T  N   F I      +S
Sbjct: 2921 GSEERTCLA----NGSWTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSS 2967

Query: 1419 LKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1477
            + Y C   Y    P    C  N  WS     C   SC  P  P NG+ +   D  VG  +
Sbjct: 2968 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNV 3026

Query: 1478 NYSCTTGH--RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENF 1535
            +Y C  G+   L G     C ++G    WS   P C+ + C  PP I+NG    T   NF
Sbjct: 3027 SYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NF 3080

Query: 1536 HYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 1595
             +G  ++Y C+ G      +EL     + C  N    G WSG  PQC +P  C  P    
Sbjct: 3081 DWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP---- 3125

Query: 1596 GILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQP 1649
            GI     R    F     V F C   F++ G     CQA   W    P C       C+ 
Sbjct: 3126 GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3185

Query: 1650 PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD 1709
            P    HG  + ++   F  G  V + C+ G+ L+G+ +  C P   WS   P C   SC 
Sbjct: 3186 PGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCK 3243

Query: 1710 DFLGQLP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCE- 1767
                + P H  V+       G  + + C  GF L G +     +    + W   VP+CE 
Sbjct: 3244 Q--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICEA 3299

Query: 1768 --HIFCPNP-PAILNGRHTGTPS 1787
               I   +P PA+      GTPS
Sbjct: 3300 GSKILVKDPRPAL------GTPS 3316



 Score =  354 bits (909), Expect = 5e-97
 Identities = 387/1478 (26%), Positives = 562/1478 (38%), Gaps = 230/1478 (15%)

Query: 828  LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV----CEQIFCPSPPVIPNGRHT 883
            +G  V F CD+G+ L+G S   C + G    WN  +P+    C         VI +    
Sbjct: 1966 VGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFP 2024

Query: 884  GKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 943
            G     +P      +T +     G     +  ST       +   V S  +    ++G  
Sbjct: 2025 GN----YPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE---VRSGSSETSTVIGRL 2077

Query: 944  QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKS 1003
              P   + + L + T+       TSL +        + F I               + +S
Sbjct: 2078 SGPQ--IPSSLFSTTHE------TSLYFHSDYSQNKQGFHIVY----------QAYQLQS 2119

Query: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063
            C  P    NG V +  D  VG  I++ C  G+ LIG+S+  C L G + +W+   P C+ 
Sbjct: 2120 CPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRCEA 2177

Query: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGGRKVFELVGEPSIYCTSNDD 1120
            + CG   T  NG   S    + +      +   R  PG+G    F ++    IY     D
Sbjct: 2178 L-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY-----D 2231

Query: 1121 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180
             + +W GP            P +      +   S++S +  +  +    F   G   +  
Sbjct: 2232 FITVWDGPDQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSY 2283

Query: 1181 QALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 1240
             A            RVCQPPP V +AE    D D F  G  + Y C PG+ L G A + C
Sbjct: 2284 HAYQL---------RVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTC 2333

Query: 1241 TP----QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLGAK 1281
                  Q D +P  P C+V    + +     G +L P               ++++ G  
Sbjct: 2334 RLGERLQMDGAP--PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYN 2391

Query: 1282 VD-----FVCDEGFQL----KGSSASYCVLAGMESLWNSSVPVCEQ-------------- 1318
            +      F  ++ F +     G +    VL  +   ++S+  +                 
Sbjct: 2392 ITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGN 2451

Query: 1319 -----------IFCPSPPVIPNG---RHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIG 1364
                        +C +P   P+G     TG  L        V + CD    RG  F L+G
Sbjct: 2452 NKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLN-----SVVRWACD----RG--FRLVG 2500

Query: 1365 ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA----SDFPIGTSLK 1420
            +S+  C     G   W +P P C  +  C  P        K  TN     +D+ +GT + 
Sbjct: 2501 KSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KAPTNGGILTTDYLVGTRVT 2551

Query: 1421 YECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTPPDPVNGMVHVITDIQVGS 1475
            Y C   Y      +T   C  +  WS+      C   SC   P P NG   + T    GS
Sbjct: 2552 YFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGN-KIGTQTSYGS 2610

Query: 1476 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENF 1535
               ++C  G  L+G +  EC+ SG    WS     C    CG+P  I NG  I    EN+
Sbjct: 2611 TAIFTCDLGFMLVGSAVRECLSSGL---WSESETRCLAGHCGIPELIVNGQVIG---ENY 2664

Query: 1536 HYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 1595
             Y   V Y+CN G      F L+G     C  + +    WSG  P C+ P  C  P   +
Sbjct: 2665 GYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG--S 2711

Query: 1596 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILH 1655
             I    + + F+ N+VV F C  G++M+GP + +CQA  +W    P C  V    P I  
Sbjct: 2712 PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPA 2771

Query: 1656 GEHTPS--HQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLG 1713
                 S     NF+ G  VFY C PGY L G++ L C P G W    P C +  C     
Sbjct: 2772 NSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--P 2829

Query: 1714 QLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI---F 1770
             +P   VL       G+ V + C     L G S   C L G    W+ S P C       
Sbjct: 2830 GVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGT 2886

Query: 1771 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVW 1830
            C +P       H      +      + Y CD        + L G     C +    NG W
Sbjct: 2887 CGDPG---TPGHGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA----NGSW 2933

Query: 1831 SSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSI-SC 1889
            +   P C+ +V+ G+  T            I+   F   +S+ Y C  GY     S+  C
Sbjct: 2934 TGRQPECK-AVQCGNPGTTAN----GKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQC 2986

Query: 1890 LENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGF--RLIGSPSTT 1947
              N  WS    NC   SCG P  P NG+     D   G  V+Y C  G+   L GS   T
Sbjct: 2987 TANGTWSGTLPNCTIISCGDPGIPANGL-RYGDDYVVGQNVSYMCQPGYTMELNGSRIRT 3045

Query: 1948 CLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQL 2007
            C ++G   TW    P C  ++C  PP ISNG       T+F  G  ++Y C  G      
Sbjct: 3046 CTING---TWSGVMPTCRAVTCPTPPQISNGRL---EGTNFDWGFSISYICSPG------ 3093

Query: 2008 FELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRF 2067
            +EL     + C       G WS   P+C+    C  P +    +  G +SF   +E + F
Sbjct: 3094 YELSFPAVLTCVGN----GTWSGEVPQCL-PKFCGDPGIPAQGKREG-KSFIYQSE-VSF 3146

Query: 2068 RCQPGFVMVGSHTVQCQTNGRWGPKLPHC----SRVCQPPPEILHGEHTLSHQDNFSPGQ 2123
             C   F++VGS T  CQ +G W    PHC       C+ P    HG    ++   F  G 
Sbjct: 3147 SCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGS 3204

Query: 2124 EVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL-QLG 2182
             V + C+  + L+G+ +  C P   WS   P C   SC     + P    ++ ++L   G
Sbjct: 3205 VVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHG 3262

Query: 2183 AKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCE 2220
              + + C  GF L G    H V       W   VP+CE
Sbjct: 3263 YTLIYTCQPGFFLAG-GTEHRVCRSDNT-WTGKVPICE 3298



 Score =  306 bits (785), Expect = 1e-82
 Identities = 268/919 (29%), Positives = 382/919 (41%), Gaps = 110/919 (11%)

Query: 43   CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTGAK 96
            C+ PE  P     + T      + + + + C  G+   G+  S +C K+S     W    
Sbjct: 2465 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2520

Query: 97   DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD- 155
              C+  SC  P  P NG + +      G+++ Y C  GYRL      T +   D   W  
Sbjct: 2521 PACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSN 2578

Query: 156  -NETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIY 214
             N+TP C  I CG  PT  NG+ I T      YGS   + C+ G      F LVG     
Sbjct: 2579 HNKTPRCVVISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRE 2629

Query: 215  CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 274
            C S+    G+WS    +C+  +   P  + NG ++ +N   +   + V ++C PGF + G
Sbjct: 2630 CLSS----GLWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIG 2682

Query: 275  PRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
                 CQ  + W  +LPSC  V C  P   ++  RT  +  NF+    V +SC  GY ++
Sbjct: 2683 SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQ 2739

Query: 334  GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEGF 390
            G    +C     WS   P C+V +C D  G   N +    +   N   G  V + C+ G+
Sbjct: 2740 GPTKAQCQANRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPGY 2798

Query: 391  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 450
             L GSS   C   G    W+  +P C  I C  P V PN   +G   E + FG TV+Y+C
Sbjct: 2799 FLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYSC 2852

Query: 451  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKLK 505
                       L+G+S+  C    Q NG WS   P C     G  G    P H       
Sbjct: 2853 T------GKRSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH------- 2895

Query: 506  TQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG 563
                 S+F   ++++Y C   Y  +G     TCL N  W+  +  CK   C  P    NG
Sbjct: 2896 GSRQESNFRTKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTANG 2954

Query: 564  MVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIA 623
             V  I      S + YSC  G+ L G S  +C  +G    WS   P C  I CG P   A
Sbjct: 2955 KVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPA 3011

Query: 624  NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
            NG       +++  G  V+Y C PG       EL G     CT N    G WSG  P C 
Sbjct: 3012 NG---LRYGDDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTCR 3060

Query: 684  IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
                 TPP + NG L   N   F     + + C PG+ +  P  + C     W  E+P C
Sbjct: 3061 AVTCPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQC 3117

Query: 744  -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 802
              + C  P       + +R+  +F    EV +SC   + L G+++  C   G WS ++P 
Sbjct: 3118 LPKFCGDPG---IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPH 3174

Query: 803  C---EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLW 859
            C      SC++  G   +G        Q+G+ V F C +G  L+GS+   C+    +  W
Sbjct: 3175 CIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLTW 3230

Query: 860  NSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR 919
            +   P C    C  P    +    G  +++   G T+ YTC P       F L G +  R
Sbjct: 3231 SGIQPECIPHSCKQPETPAHANVVG--MDLPSHGYTLIYTCQP------GFFLAGGTEHR 3282

Query: 920  -CTSDPQGNGVWSSPAPRC 937
             C SD      W+   P C
Sbjct: 3283 VCRSD----NTWTGKVPIC 3297



 Score =  291 bits (744), Expect = 7e-78
 Identities = 240/829 (28%), Positives = 335/829 (40%), Gaps = 96/829 (11%)

Query: 62   EFPIGTYLNYECRPGY---SGRPFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVH 116
            ++ +GT + Y C  GY   S    + +C  +  W+      RC   SC   P P NG   
Sbjct: 2543 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGN-K 2601

Query: 117  VIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGD 176
            +     +GS   ++C  G+ L+GS+   C+ SG   +W      C    CG+P  I NG 
Sbjct: 2602 IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ 2658

Query: 177  FISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN 236
             I    EN+ Y   V Y+CNPG      F L+G     C  + +    WSG  P C+ P 
Sbjct: 2659 VIG---ENYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PV 2704

Query: 237  KCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             C  P   + I    + + F+ N+VV F C  G++M+GP + +CQA  +W    P C  V
Sbjct: 2705 SCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVV 2762

Query: 297  -CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354
             C  P    +++R  + +  NF+ G  VFY C PGY L G++ + C P G W    P C 
Sbjct: 2763 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2822

Query: 355  VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVP 414
            +  C      +    VL       G+ V + C     L G S+  C L G    W+ S P
Sbjct: 2823 MIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQP 2877

Query: 415  VC--EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTS 472
             C  +       P  P   H  +    F    TV Y CD      T + L G     C +
Sbjct: 2878 HCSGDATGTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA 2929

Query: 473  DPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTSLKYECRPEY 527
                NG W+   P C  +  C  P         T  N   F I      +S+ Y C   Y
Sbjct: 2930 ----NGSWTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSSVIYSCMEGY 2976

Query: 528  -YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH- 585
                P    C  N  WS     C   SC  P  P NG+ +   D  VG  ++Y C  G+ 
Sbjct: 2977 ILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYT 3035

Query: 586  -RLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYR 644
              L G     C ++G    WS   P C+ + C  PP I+NG    T   NF +G  ++Y 
Sbjct: 3036 MELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYI 3089

Query: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR- 703
            C+PG      +EL     + C  N    G WSG  PQC +P  C  P    GI     R 
Sbjct: 3090 CSPG------YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP----GIPAQGKRE 3134

Query: 704  -SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQPPPDVLHAER 758
               F     V F C   F++ G     CQA   W    P C       C+ P    H   
Sbjct: 3135 GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG-- 3192

Query: 759  TQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNG 818
            +Q +   F  G  V + C+ G+ L+G+ +  C P   WS   P C   SC        + 
Sbjct: 3193 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-PETPAHA 3251

Query: 819  RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867
             V+       G  + + C  GF L G +     +   ++ W   VP+CE
Sbjct: 3252 NVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICE 3298



 Score =  286 bits (731), Expect = 2e-76
 Identities = 440/1946 (22%), Positives = 692/1946 (35%), Gaps = 382/1946 (19%)

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGI 697
            GS + Y CNPG      + L G   + C + + +   W  P P CI           +G 
Sbjct: 1270 GSTIIYGCNPG------YTLHGSSLLKCMTGERRA--WDYPLPSCIAECGGRFKGESSGR 1321

Query: 698  LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD----- 752
            ++S        N +   RC     +     V  Q L           RV   PP+     
Sbjct: 1322 ILSPGYPFPYDNNL---RCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLL 1378

Query: 753  --------------VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
                           L+    Q D D        FY  + G+ ++ ++S+    +    P
Sbjct: 1379 KEISGSLIPEGIHSTLNIVTIQFDTD--------FYISKSGFAIQFSSSVATACR---DP 1427

Query: 799  AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
              P    ++ D        GR       + G  V F CD G++L+G     C+       
Sbjct: 1428 GVPMNGTRNGD--------GR-------EPGDTVVFQCDPGYELQGEERITCIQVENRYF 1472

Query: 859  WNSSVPVCEQIFCPSPPVIP-NGRHTGKPLEV--------FPFGKTVNYTCDPHPDRGTS 909
            W  S PVC         + P  G  TG    +        +P  +  ++T   + D   S
Sbjct: 1473 WQPSPPVC---------IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVIS 1523

Query: 910  FDLIGESTIRCTSDPQGNG--VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGT 967
               I  S      +P  +   ++  P     ++G  Q       +KL  +  +S   +  
Sbjct: 1524 LAFISFSI-----EPNYDFLYIYDGPDSNSPLIGSFQD------SKLPERIESSSNTMHL 1572

Query: 968  SLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1027
            + + +    Y G  F +     L          R+SC  P + +NG   +  D ++GS +
Sbjct: 1573 AFRSDGSVSYTG--FHLEYKAKL----------RESCFDPGNIMNG-TRLGMDYKLGSTV 1619

Query: 1028 NYSCTTGHRLIGHSSAECILSGNAAH-WSTKPPICQRIPCGLPPTIANGDFISTNR-ENF 1085
             Y C  G+ L G+S+  CI+  +    W+   P C   PCG   T + G  +S N  +N+
Sbjct: 1620 TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNY 1678

Query: 1086 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 1145
              G    + C       K F + G+   + TS  D V ++ GP  Q  + +  +  +   
Sbjct: 1679 SVG----HNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGE 1734

Query: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 1205
             + +S    +      + F        KG   V  QA+ +       CS V +P      
Sbjct: 1735 SLPLSSGNQI-----TIRFTSVGPITAKGFHFVY-QAVPRTSST--QCSSVPEP------ 1780

Query: 1206 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC----TPQGDWSPAAPTCEVKSCDDF 1261
                +R  + F+ G  V + C PGY L G+ ++RC         W+ + PTC +  C   
Sbjct: 1781 -RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGI 1838

Query: 1262 M----GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL--------- 1308
            +    G +L+     P +  L         EG  ++    S+      +SL         
Sbjct: 1839 LTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1898

Query: 1309 --------------------------WNSSVPVCEQIF-----------CPSPPVIPNGR 1331
                                      + S + V    F           CP P    +G 
Sbjct: 1899 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGI 1958

Query: 1332 HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 1387
              G   + +  G  V++ CD        + L G S I C   P     W+ P P C    
Sbjct: 1959 KIG---DRYMVGDVVSFQCDQ------GYSLQGHSHITCMPGPVRR--WNYPIPICLAQC 2007

Query: 1388 --------GILGHCQAPD--------------------HFLFAKLKTQT-------NASD 1412
                    G++     P                     H  F    T+T        +  
Sbjct: 2008 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2067

Query: 1413 FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKR-----------KSCKTPPDPV 1461
                T +     P+     FS T   +L + S     K+           +SC  P    
Sbjct: 2068 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 2127

Query: 1462 NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPT 1521
            NG V +  D  VG  I++ C  G+ LIG+S+  C L G + +W+   P C+ + CG   T
Sbjct: 2128 NGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPLPRCEAL-CGGNIT 2184

Query: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKV---FELVGEPSIYCTSNDDQVGIWSGP 1578
              NG   S    + +      +       G  +   F ++    IY     D + +W GP
Sbjct: 2185 AMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY-----DFITVWDGP 2239

Query: 1579 APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP 1638
                        P +      +   S++S +  +  +    F   G   +   A      
Sbjct: 2240 DQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQL--- 2288

Query: 1639 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSP 1698
                  RVCQPPP + + E   +  D F  G  + Y C PG+ L G A L          
Sbjct: 2289 ------RVCQPPPPVPNAEIL-TEDDEFEIGDIIRYQCLPGFTLVGNAIL---------- 2331

Query: 1699 EAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL-VGMRS 1757
                C +       G  P  +VL P N         +   G+     ++  C   + +  
Sbjct: 2332 ---TCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEK 2388

Query: 1758 LWNNSVPV----CEHIFCPNPPAILNGRHTGTP-----SGDIPYGKEISYTCDPHPDRGM 1808
             +N ++ V     E  F  +   + +G +  +P     SGD  Y    + T + H     
Sbjct: 2389 GYNITMFVEFFQTEKEF--DVLQVYDGPNIQSPVLISLSGD--YSSAFNITSNGH----- 2439

Query: 1809 TFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPV 1868
                  E  ++ ++D HGN           +   A +C TPE  P       I+     +
Sbjct: 2440 ------EVFLQWSAD-HGNN-----KKGFRIRYIAFYCSTPESPPHG---YIISQTGGQL 2484

Query: 1869 GTSLNYECRPGY--FGKMFSI---SCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTD 1923
             + + + C  G+   GK  ++   S      W +    C+  SCG P  P NG + + TD
Sbjct: 2485 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-LTTD 2543

Query: 1924 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDK--KAPICEIISCEPPPTISNGDFY 1981
               G+ V Y CN+G+RL     TT +   +  TW    K P C +ISC   PT  NG+  
Sbjct: 2544 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG-TWSNHNKTPRCVVISCGELPTPPNGNKI 2602

Query: 1982 SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKC 2041
               +TS+  G+   + C  G      F LVG     C S     G+WS    RC++ + C
Sbjct: 2603 GT-QTSY--GSTAIFTCDLG------FMLVGSAVRECLSS----GLWSESETRCLAGH-C 2648

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-C 2100
              PE+    +V G    +   + + ++C PGF ++GS    CQ +  W  +LP C  V C
Sbjct: 2649 GIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSC 2706

Query: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS 2160
              P   ++G    +  + F+    V +SC   Y ++G     C     WS   P C V +
Sbjct: 2707 GHPGSPIYGR---TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2763

Query: 2161 CDD--------FLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
            C D           ++ HG      N   G  V + C+ G+ L G S   C   G    W
Sbjct: 2764 CSDPGIPANSKRESKIEHG------NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---W 2814

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +  +P C  I C +P    N   +G  +    +G  + Y+C          +L+G+SS  
Sbjct: 2815 DKPLPECIMIDCGHPGVPPNAVLSGEKY---TFGSTVHYSCTGKR------SLLGQSSRT 2865

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C    Q NG WS   P C       C  P    +G       S +    T+ Y CD GY+
Sbjct: 2866 C----QLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYI 2918

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKV--YHYGDYVTLKCED 2390
            L G     C   G W+     CK V C  P    G +   ++ ++    +   V   C +
Sbjct: 2919 LHGSEERTCLANGSWTGRQPECKAVQCGNP----GTTANGKVFRIDGTTFSSSVIYSCME 2974

Query: 2391 GYTLEGSPWSQCQADDRWDPPLAKCT 2416
            GY L G    QC A+  W   L  CT
Sbjct: 2975 GYILSGPSVRQCTANGTWSGTLPNCT 3000



 Score =  278 bits (711), Expect = 5e-74
 Identities = 243/858 (28%), Positives = 342/858 (39%), Gaps = 118/858 (13%)

Query: 1589 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ----ALNKWEPELPSCS 1644
            TP +  +G ++S       LN VV + C  GF + G     C+      + W+  +P+C 
Sbjct: 2467 TPESPPHGYIISQTGG--QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2524

Query: 1645 RV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDL--RGAASLHCTPQGDWSP--E 1699
             + C  P    +G    +   ++  G  V Y C  GY L  +   +  C   G WS   +
Sbjct: 2525 AISCGIPKAPTNGGILTT---DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2581

Query: 1700 APRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1759
             PRC V SC + L   P+G  +       G+   F CD GF L GS+V  C+  G   LW
Sbjct: 2582 TPRCVVISCGE-LPTPPNGNKI-GTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG---LW 2636

Query: 1760 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
            + S   C    C  P  I+NG+  G   G   Y   + Y C+P       F LIG S   
Sbjct: 2637 SESETRCLAGHCGIPELIVNGQVIGENYG---YRDTVVYQCNPG------FRLIGSSVRI 2687

Query: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPG 1879
            C  D +    WS   P C + V  GH  +P     +      ND        + + C  G
Sbjct: 2688 CQQDHN----WSGQLPSC-VPVSCGHPGSPIYGRTSGNGFNFNDV-------VTFSCNIG 2735

Query: 1880 YFGK-MFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDT---QFGSTVNYSCN 1935
            Y  +      C  N  WS     C+  +C  P  P N       +     +G+ V Y CN
Sbjct: 2736 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2795

Query: 1936 EGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE----PPPTISNGDFYSNNRTSFHNG 1991
             G+ L GS    C  +G    WDK  P C +I C     PP  + +G+ Y+        G
Sbjct: 2796 PGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSGEKYTF-------G 2845

Query: 1992 TVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCI--STNKCTAPEVENA 2049
            + V Y C TG        L+G+ S  C       G WS   P C   +T  C  P     
Sbjct: 2846 STVHYSC-TGKRS-----LLGQSSRTCQLN----GHWSGSQPHCSGDATGTCGDPGT--- 2892

Query: 2050 IRVPGN----RSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPP 2104
               PG+     S F     +R+ C  G+++ GS    C  NG W  + P C  V C  P 
Sbjct: 2893 ---PGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG 2949

Query: 2105 EILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDF 2164
               +G+        FS    V YSC   Y L G +   CT  G WS   P CT+ SC D 
Sbjct: 2950 TTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGD- 3006

Query: 2165 LGQLPHGRVLLPLNLQLGAKVSFVCDEGF--RLKGRSASHCVLAGMKALWNSSVPVCEQI 2222
               +P   +    +  +G  VS++C  G+   L G     C + G    W+  +P C  +
Sbjct: 3007 -PGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAV 3062

Query: 2223 FCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGV 2282
             CP PP I NGR  GT F    +G  ISY C   P   ++F  +    + C     GNG 
Sbjct: 3063 TCPTPPQISNGRLEGTNF---DWGFSISYICS--PGYELSFPAV----LTCV----GNGT 3109

Query: 2283 WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT 2342
            WS   P+C   +P  C  P     G   G     ++    +S+ C+  ++LVG     C 
Sbjct: 3110 WSGEVPQC---LPKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQ 3163

Query: 2343 DQGIWSQLDHYCKE---VNCSFPLFMNGISKELEMKKVYHY--GDYVTLKCEDGYTLEGS 2397
              G WS    +C E    +C  P    G+ +       + +  G  V   C+ G+ L+GS
Sbjct: 3164 ADGTWSGSSPHCIEPTQTSCENP----GVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGS 3219

Query: 2398 PWSQCQADDRWDPPLAKC 2415
                C  D  W     +C
Sbjct: 3220 TTRTCLPDLTWSGIQPEC 3237



 Score =  270 bits (689), Expect = 2e-71
 Identities = 242/925 (26%), Positives = 370/925 (40%), Gaps = 117/925 (12%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  P +  +G  IS      +  SVV + C+ G      F LVG+ S  C  +      W
Sbjct: 2465 CSTPESPPHGYIISQTGGQLN--SVVRWACDRG------FRLVGKSSAVCRKSSYGYHAW 2516

Query: 1576 SGPAPQCIIPNKCTPPNVENG-ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK--CQA 1632
              P P C   +   P    NG IL +D    + +   V + C  G+ +         CQ+
Sbjct: 2517 DAPVPACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQS 2572

Query: 1633 LNKWEPE-------LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
               W          + SC  +  PP     G  T       S G    ++C+ G+ L G+
Sbjct: 2573 DGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQT-------SYGSTAIFTCDLGFMLVGS 2625

Query: 1686 ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGS 1745
            A   C   G WS    RC    C   + +L     +   N      V + C+ GFRL GS
Sbjct: 2626 AVRECLSSGLWSESETRCLAGHCG--IPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGS 2683

Query: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
            SV  C        W+  +P C  + C +P + + GR +G       +   ++++C+    
Sbjct: 2684 SVRICQ---QDHNWSGQLPSCVPVSCGHPGSPIYGRTSGN---GFNFNDVVTFSCN---- 2733

Query: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865
              + + + G +  +C +    N  WS P P C++     +C  P     +     I    
Sbjct: 2734 --IGYLMQGPTKAQCQA----NRQWSHPPPMCKVV----NCSDPGIPANSKRESKIEHGN 2783

Query: 1866 FPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922
            F  GT + Y+C PGYF  +F  S   C  N  W      C    CG P  P N ++    
Sbjct: 2784 FTYGTVVFYDCNPGYF--LFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK 2841

Query: 1923 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE---IISCEPPPTISNGD 1979
             T FGSTV+YSC     L+G  S TC ++G+   W    P C      +C  P T  +G 
Sbjct: 2842 YT-FGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG- 2896

Query: 1980 FYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTN 2039
              S   ++F   + V Y C TG      + L G     C +     G W+   P C +  
Sbjct: 2897 --SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAV- 2943

Query: 2040 KCTAPEVE---NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC 2096
            +C  P         R+ G     T +  + + C  G+++ G    QC  NG W   LP+C
Sbjct: 2944 QCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 2999

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY--DLRGAASLHCTPQGDWSPEAP 2154
            + +    P I    + L + D++  GQ V Y C+P Y  +L G+    CT  G WS   P
Sbjct: 3000 TIISCGDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP 3057

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNS 2214
             C   +C     Q+ +GR L   N   G  +S++C  G+ L   +   CV  G    W+ 
Sbjct: 3058 TCRAVTCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSG 3112

Query: 2215 SVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCT 2274
             VP C   FC +P     G+  G  F    Y  E+S++C+        F L+G S+  C 
Sbjct: 3113 EVPQCLPKFCGDPGIPAQGKREGKSF---IYQSEVSFSCN------FPFILVGSSTRICQ 3163

Query: 2275 SDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLV 2334
            +D    G WS  +P C      +C +P   ++G     +   +  G  + + C  G+LL 
Sbjct: 3164 AD----GTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHCKKGHLLQ 3217

Query: 2335 GKGFIFCTDQGIWSQLDHYCKEVNC---SFPLFMNGISKELEMKKVYHYGDYVTLKCEDG 2391
            G     C     WS +   C   +C     P   N +  +L       +G  +   C+ G
Sbjct: 3218 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLP-----SHGYTLIYTCQPG 3272

Query: 2392 YTLEGSPWSQ-CQADDRWDPPLAKC 2415
            + L G    + C++D+ W   +  C
Sbjct: 3273 FFLAGGTEHRVCRSDNTWTGKVPIC 3297



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 99/409 (24%)

Query: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965
            C  P EP NG   I +D   GSTV +SC+E + L G+ S TC  ++     W    P+C+
Sbjct: 382  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 1966 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 2000
            + +C      P  T ++ +F   Y +N       T+ +   V+            Y   T
Sbjct: 441  VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500

Query: 2001 GPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTN--------KCTAPEVEN-AI 2050
              DG ++ +      +   S   D +   SS     + T+        K    E+E  + 
Sbjct: 501  IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560

Query: 2051 RVPGNRSF-------FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-----SR 2098
              PG   +       F+  +++RF CQ GF ++G  ++ CQ N +W   +P C     S 
Sbjct: 561  GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 620

Query: 2099 VCQPPPEILHGEHTLSHQDNFS--------PGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
               P   +L  ++   + +N +        PG  +  S    +DL           GD S
Sbjct: 621  FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-S 678

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPL--------------------------------- 2177
            PE+P     +  +    L     +L L                                 
Sbjct: 679  PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPIN 738

Query: 2178 ------NLQLGAKVSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVC 2219
                  N QLG+ +S +C+EGF + +G     C+L   K +W+  +P C
Sbjct: 739  ARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 225/1043 (21%), Positives = 355/1043 (34%), Gaps = 219/1043 (20%)

Query: 183  ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP- 241
            +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+C  P  C    
Sbjct: 744  DNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPKCGAP--CGGHF 795

Query: 242  NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
            +  +G+++S     +   SLN       +PG  +K           +++ EL        
Sbjct: 796  SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQTELNYDVLEVH 848

Query: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358
              P++L         +     Q +F S    Y L    + R          + T    SC
Sbjct: 849  DGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 906

Query: 359  DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418
             D  G  ++GR  +  +  +G+ V F CD G++L       C        W+  +P C+ 
Sbjct: 907  LD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 961

Query: 419  IFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD-------------LI 463
            + C      P+G     G P E +P      +T D    +G  F+             LI
Sbjct: 962  L-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1019

Query: 464  GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
             E+        +  G    P    G+ G+ +A   F+          SDF    S+ YE 
Sbjct: 1020 TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SDF----SISYE- 1064

Query: 524  RPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCT 582
                    F+IT  + NL           + C+ P  P  G   +  +  +G  + +SC+
Sbjct: 1065 -------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNFGIGDTLTFSCS 1105

Query: 583  TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR----ENFHYG 638
            +G+RL G S   C L G    WS   P C    CG   T   G  +S N     EN H  
Sbjct: 1106 SGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHE- 1162

Query: 639  SVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695
             + + +   G G     + F L         +  D + I+ G      +    T  ++  
Sbjct: 1163 CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHLLGAFTGASMRG 1213

Query: 696  GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
              L S +  L+     +EF        +G + V          EL  C       P +  
Sbjct: 1214 LTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE-----DPGIPQ 1257

Query: 756  AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMG 813
                  D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+C  +    F G
Sbjct: 1258 FGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1316

Query: 814  QLLNGRVL-----FPVNLQLGAKVDFVCDEG------FQLKGSSASYCVLAGMESLWNSS 862
            +  +GR+L     FP +  L        D G      F    + AS+ +L     +W+  
Sbjct: 1317 E-SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDIL----RVWDGP 1371

Query: 863  VPVCEQIFCPSPPVIPNGRHTGKPLEVFPF------------------------------ 892
                  +   S  +IP G H+   +    F                              
Sbjct: 1372 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1431

Query: 893  -----------GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 937
                       G TV + CDP       ++L GE  I C    +    W    P C    
Sbjct: 1432 NGTRNGDGREPGDTVVFQCDP------GYELQGEERITCI-QVENRYFWQPSPPVCIAPC 1484

Query: 938  -----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW 992
                 G  G   +P+   F      +   D+ I  +  Y     +    FSI    + ++
Sbjct: 1485 GGNLTGSSGFILSPN---FPHPYPHSRDCDWTITVNADYVISLAFIS--FSIEPNYDFLY 1539

Query: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052
                           PD  + ++    D ++  RI  S  T H L   S      +G   
Sbjct: 1540 -----------IYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTGFHL 1587

Query: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112
             +  K     R  C  P  I NG  +     ++  GS VTY C+ G      + L G  +
Sbjct: 1588 EYKAK----LRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYST 1634

Query: 1113 IYCTSNDDQVGIWSGPAPQCIIP 1135
            + C   DD    W+   P C  P
Sbjct: 1635 LTCIMGDDGRPGWNRALPSCHAP 1657



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 82/293 (27%), Positives = 123/293 (41%), Gaps = 33/293 (11%)

Query: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSTKPPIC 1511
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S NTA W    PIC
Sbjct: 177  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 1512 Q-RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV------FELVGEPSIY 1564
            +    CG     ++G   S +  N ++ +       +   G  +      F++  +    
Sbjct: 236  RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYL 295

Query: 1565 CTSNDDQVGIW-SG-PAPQCIIPNKCTPPNVENGILVSDNR-------SLFSLNEVVEFR 1615
                 +   IW SG   P  II NK    N      V+D+        + + + + ++F+
Sbjct: 296  EIEGSEPPTIWLSGMNIPPPIISNK----NWLRLHFVTDSNHRYRGFSAPYQVKKAIDFK 351

Query: 1616 CQPGFVMKG-PRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFY 1674
             +   +  G     K   LN  E  + + S +C  P E  +G+   S   +FS G  V +
Sbjct: 352  SRGFKLFPGKDNSNKFSILN--EGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTVQF 406

Query: 1675 SCEPGYDLRGAASLHCTPQGD----WSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
            SC+  Y L+GA S+ C    +    WS   P C VK+C   L Q P G    P
Sbjct: 407  SCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 458



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 196/861 (22%), Positives = 310/861 (36%), Gaps = 172/861 (19%)

Query: 460  FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 519
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 590  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 629

Query: 520  KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 564
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 630  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 685

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPC-GLPPTIA 623
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 686  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 736

Query: 624  NGDFISTNR--ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 737  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 786

Query: 682  CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 737
            C  P  C    +  +G+++S     +   SLN       +PG  +K           +++
Sbjct: 787  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQ 837

Query: 738  PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
             EL          P++L         +     Q +F S    Y L    + R        
Sbjct: 838  TELNYDVLEVHDGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 895

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 857
              + T    SC D  G  ++GR  +  +  +G+ V F CD G++L       C       
Sbjct: 896  YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNH 950

Query: 858  LWNSSVPVCEQIFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD---- 911
             W+  +P C+ + C      P+G     G P E +P      +T D    +G  F+    
Sbjct: 951  WWSHPLPTCDAL-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTF 1008

Query: 912  ---------LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD 962
                     LI E+        +  G    P    G+ G+ +A   F+          SD
Sbjct: 1009 HLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SD 1058

Query: 963  FPIGTSLKYECRPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDI 1021
            F    S+ YE         F+IT  + NL           + C+ P  P  G   +  + 
Sbjct: 1059 F----SISYE--------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNF 1094

Query: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081
             +G  + +SC++G+RL G S   C L G    WS   P C    CG   T   G  +S N
Sbjct: 1095 GIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPN 1152

Query: 1082 R----ENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 1134
                 EN H   + + +   G G     + F L         +  D + I+ G      +
Sbjct: 1153 YPLNYENNHE-CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHL 1202

Query: 1135 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1194
                T  ++    L S +  L+     +EF        +G + V          EL  C 
Sbjct: 1203 LGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE 1251

Query: 1195 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPT 1252
                  P +        D+ +F+ G  + Y C PGY L G++ ++C    +  W    P+
Sbjct: 1252 -----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPS 1305

Query: 1253 CEVKSCDDFMGQLLNGRVLFP 1273
            C  +    F G+  +GR+L P
Sbjct: 1306 CIAECGGRFKGE-SSGRILSP 1325



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 75/279 (26%), Positives = 116/279 (41%), Gaps = 34/279 (12%)

Query: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 611
           SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S N A W    PIC
Sbjct: 177 SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 612 Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 667
           +    CG     ++G   S +  N +H  +  T+     PG     +F            
Sbjct: 236 RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 290

Query: 668 NDDQVGIWSGPAPQCIIPNKCTPPNV---ENGI---LVSDNR-------SLFSLNEVVEF 714
             D + I     P   +     PP +   +N +    V+D+        + + + + ++F
Sbjct: 291 KYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDF 350

Query: 715 RCQPGFVMKG-PRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
           + +   +  G     K   LN  E  + + S +C   PD    E  +R   +FS G  V 
Sbjct: 351 KSRGFKLFPGKDNSNKFSILN--EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQ 405

Query: 774 YSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSC 808
           +SC+  Y L+GA S+ C    +    WS   P C+VK+C
Sbjct: 406 FSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 75/279 (26%), Positives = 116/279 (41%), Gaps = 34/279 (12%)

Query: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 1061
            SC  P  P  G+++  T   VG +I YSC TG+ L GH    CI  S N A W    PIC
Sbjct: 177  SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 1062 Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 1117
            +    CG     ++G   S +  N +H  +  T+     PG     +F            
Sbjct: 236  RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 290

Query: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNV---ENGI---LVSDNR-------SLFSLNEVVEF 1164
              D + I     P   +     PP +   +N +    V+D+        + + + + ++F
Sbjct: 291  KYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDF 350

Query: 1165 RCQPGFVMKG-PRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 1223
            + +   +  G     K   LN  E  + + S +C   PD    E  +R   +FS G  V 
Sbjct: 351  KSRGFKLFPGKDNSNKFSILN--EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQ 405

Query: 1224 YSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSC 1258
            +SC+  Y L+GA S+ C    +    WS   P C+VK+C
Sbjct: 406  FSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 134/603 (22%), Positives = 207/603 (34%), Gaps = 149/603 (24%)

Query: 1606 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPEILHGEHTP 1660
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   +L  ++  
Sbjct: 576  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 635

Query: 1661 SHQDNFS--------PGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP----------- 1701
             + +N +        PG  +  S    +DL           GD SPE+P           
Sbjct: 636  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 693

Query: 1702 ----------RCAVKSCDDFLGQ------------------LPHGRVLFPLNLQLGAKVS 1733
                      R   ++     G+                  +P     F  N QLG+ +S
Sbjct: 694  SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSIS 753

Query: 1734 FVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI-- 1790
             +C+EGF + +G+    C+L+  + +W+  +P C        P    G H   PSG I  
Sbjct: 754  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC------GAPC---GGHFSAPSGVILS 804

Query: 1791 ---PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSV 1841
               P   + S  C      +P     +TF            + H      SP     L  
Sbjct: 805  PGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP-----LLG 859

Query: 1842 RAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1901
                 + P QF F+S     ++F + + T+ N     G+            + + SV  N
Sbjct: 860  SYNGTQVP-QFLFSS-----SNFIYLLFTTDNSRSNNGF-----------KIHYESVTVN 902

Query: 1902 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961
                SC  P  P +G      D   GSTV++SC+ G+RL       C     N  W    
Sbjct: 903  --TYSCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPL 956

Query: 1962 PICEIIS----CEPPPTISN---GDFYSNN-----RTSFHNGTVVTYQCHT-GPDGEQLF 2008
            P C+ +       P  TI +    +FY N+          +G  V +  HT   +    +
Sbjct: 957  PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1016

Query: 2009 ELVGERSIYCTSKDDQVGVWSSPPP--------------RCISTNKCT------------ 2042
             L+ E   +        G  S  PP              R IS    +            
Sbjct: 1017 LLITENGSFTQPLARLTG--SDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074

Query: 2043 -APEVENAIRVPGNRSFFT--LTEIIRFRCQPGFVMVGSHTVQCQTNGR--WGPKLPHCS 2097
              P  +  I   G+R  F   + + + F C  G+ + G+  + C   GR  W   LP C 
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134

Query: 2098 RVC 2100
              C
Sbjct: 1135 AEC 1137



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 74/285 (25%), Positives = 118/285 (41%), Gaps = 34/285 (11%)

Query: 97  DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWD 155
           +  +  SC NP  P  G+++  +    G +I+YSC  GY L G    TCI  S +T  WD
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229

Query: 156 NETPIC-DRIPCGLPPTITNGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEP 211
              PIC     CG     ++G   S +  N +H  +  T+     PG     +F      
Sbjct: 230 FPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----T 284

Query: 212 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV---ENGI---LVSDNR-------SLFSL 258
                   D + I     P   +     PP +   +N +    V+D+        + + +
Sbjct: 285 DFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQV 344

Query: 259 NEVVEFRCQPGFVMKG-PRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFS 317
            + ++F+ +   +  G     K   LN  E  + + S +C   PD    E  +R   +FS
Sbjct: 345 KKAIDFKSRGFKLFPGKDNSNKFSILN--EGGIKTASNLC---PDPGEPENGKRIGSDFS 399

Query: 318 PGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSC 358
            G  V +SC+  Y L+GA S+ C    +    WS   P C+VK+C
Sbjct: 400 LGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 77/295 (26%), Positives = 121/295 (41%), Gaps = 25/295 (8%)

Query: 1900 DNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWD 1958
            +  +  SCG P  P  G+++  T    G  + YSC  G+ L G P  TC+  S N  +WD
Sbjct: 171  EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229

Query: 1959 KKAPICEI-ISCEPPPTISNGDFYSNN-RTSFHNGTVVTYQCHTGPDGEQL------FEL 2010
               PIC    +C      S+G   S +    +HN    T+     P G+ +      F++
Sbjct: 230  FPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEP-GDTISLIFTDFQM 288

Query: 2011 VGERSIYCTSKDDQVGVWSS----PPPRCISTNKCTAPEV-ENAIRVPGNRSFFTLTEII 2065
              +         +   +W S    PPP   + N      V ++  R  G  + + + + I
Sbjct: 289  EEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAI 348

Query: 2066 RFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEV 2125
             F+ + GF +        + +      +   S +C  P E  +G+   S   +FS G  V
Sbjct: 349  DFKSR-GFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTV 404

Query: 2126 FYSCEPSYDLRGAASLHCTPQGD----WSPEAPRCTVKSCDDFLGQLPHGRVLLP 2176
             +SC+  Y L+GA S+ C    +    WS   P C VK+C   L Q P G    P
Sbjct: 405  QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 458



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 203/866 (23%), Positives = 304/866 (35%), Gaps = 179/866 (20%)

Query: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 1419
            F+LIGE +I C    Q N  WS+  P C            +F  L   T     P+GT L
Sbjct: 590  FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 629

Query: 1420 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 1464
              +  PE YG   ++ C+  ++                 S  D    K   +P  P+ G 
Sbjct: 630  SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 685

Query: 1465 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC-GLPPTIA 1523
                T  +V S +    +  H L     A+  +SG   + +         P  G+P    
Sbjct: 686  --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 736

Query: 1524 NGDFISTNR--ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581
                I+  R  +NF  GS ++  C  G       +  G  +I C   D +V +WSG  P+
Sbjct: 737  ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 786

Query: 1582 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1637
            C  P  C    +  +G+++S     +   SLN       +PG  +K         LN   
Sbjct: 787  CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 844

Query: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697
             E+     +  P     +G   P    + S    + ++ +      G   +H        
Sbjct: 845  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGF-KIHY------- 896

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS 1757
             E+      SC D  G   HGR  +  +  +G+ VSF CD G+RL   S    +L     
Sbjct: 897  -ESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 950

Query: 1758 LWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI---------PYGKEISYTCDPHPDRGM 1808
             W++ +P C+        A+  G   G PSG I         P     ++T D    +G+
Sbjct: 951  WWSHPLPTCD--------ALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1001

Query: 1809 TFNLIGESTIRCTSDPHG------NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1862
             FN     T     D H       NG ++ P  R   S             F +    I+
Sbjct: 1002 QFNF---HTFHL-EDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFIS 1057

Query: 1863 DFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922
            DF      S++YE     F   FS   LE               C  P  P  G   I  
Sbjct: 1058 DF------SISYEG----FNITFSEYNLE--------------PCEDPGIPQYGS-RIGF 1092

Query: 1923 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS 1982
            +   G T+ +SC+ G+RL G+    CL  G  V W    P C +  C    T + G   S
Sbjct: 1093 NFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-VAECGASATNNEGILLS 1150

Query: 1983 -NNRTSFHNGTVVTY--QCHTGPD---GEQLFELV-GERSIYCTSKDDQ---VGVWSSPP 2032
             N   ++ N     Y  Q   G       + F L  G+       KD     +G ++   
Sbjct: 1151 PNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGAS 1210

Query: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPK 2092
             R +     T     N + +  N       E        GF +V +             +
Sbjct: 1211 MRGL-----TLSSTSNQLWLEFNSDTEGTDE--------GFQLVYTSF-----------E 1246

Query: 2093 LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT--PQGDWS 2150
            L HC       P I    + +S Q +F+ G  + Y C P Y L G++ L C    +  W 
Sbjct: 1247 LSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWD 1300

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLP 2176
               P C  +    F G+   GR+L P
Sbjct: 1301 YPLPSCIAECGGRFKGE-SSGRILSP 1325



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 107/455 (23%), Positives = 163/455 (35%), Gaps = 100/455 (21%)

Query: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVIWDNETPICD 162
           C +P +P NG   +      GS +++SC + Y L G+ S TC  I+     W +  P+C 
Sbjct: 382 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 163 RIPC-----GLPPTITNGDF----------------ISTNRE---NFH-YGSVVTY-RCN 196
              C     G   T T+ +F                ++TN+    NF  +   + Y    
Sbjct: 441 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500

Query: 197 PGSGG-----RKVFE-LVGE--PSIYCTSN---------DDQVG-IWSGPAPQCIIPNKC 238
            G GG     R V + L G   P +  + +         D+ VG +      + I    C
Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560

Query: 239 TPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---- 293
             P     GI   D    FS  +V+ F CQ GF + G + + CQ  N+W   +P C    
Sbjct: 561 GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 617

Query: 294 -SRVCQPPPDVLHAERTQRDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQG 344
            S    P   VL  +  +   +N +        PG  +  S    +DL           G
Sbjct: 618 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 676

Query: 345 DWSPAAPTCEVKSCDDFMGQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403
           D SP +P     +  +    L  N  +L         +++F  D     +G + +Y    
Sbjct: 677 D-SPESPILGTFTGAEVPSHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFG 726

Query: 404 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
             E              CP P +  N R  G   + F  G +++  C+            
Sbjct: 727 HNE--------------CPDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQ 764

Query: 464 GESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAP 496
           G  TI C     G  +WS   P+CG    GH  AP
Sbjct: 765 GTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 798



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 137/619 (22%), Positives = 201/619 (32%), Gaps = 134/619 (21%)

Query: 384  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 442
            F C  GF+L G  +  C      + W++++P+C  IF C S    P G         +P 
Sbjct: 584  FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 635

Query: 443  GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
            G   N  C      DP      SF D   ES     +   G+   S  +P  G     + 
Sbjct: 636  GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 692

Query: 496  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 555
            P H         T+ S       L+++      GR F+IT           +      C 
Sbjct: 693  PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 731

Query: 556  TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 614
             P  P+N       + Q+GS I+  C  G  +  G  +  CIL      WS   P C   
Sbjct: 732  DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 789

Query: 615  PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
            PCG   +  +G  +S     ++  S+         PG   +  FE           N D 
Sbjct: 790  PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 844

Query: 672  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731
            + +  GP     +        V    L S +  ++ L      R   GF +      +  
Sbjct: 845  LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 899

Query: 732  ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791
             +N +          C  P   +H  R   D   FS G  V +SC+ GY L     + C 
Sbjct: 900  TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 947

Query: 792  PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 841
                WS   PTC+     D  G   +G +L       +P +L     VD    +G Q   
Sbjct: 948  KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1005

Query: 842  --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 870
                                      L GS     + AG+   + + +            
Sbjct: 1006 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1065

Query: 871  ------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
                        C  P +   G   G     F  G T+ ++C       + + L G S I
Sbjct: 1066 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1116

Query: 919  RCTSDPQGNGVWSSPAPRC 937
             C     G  VWS+P PRC
Sbjct: 1117 ICLGG--GRRVWSAPLPRC 1133



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 132/647 (20%), Positives = 223/647 (34%), Gaps = 127/647 (19%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G     +G   GS I Y C  GY L GSS   C+ +G+   WD   P C  
Sbjct: 1250 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIA 1308

Query: 164  IPCGLPPTITNGDFISTNRENFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTS 217
               G     ++G  +S     F Y +    RC      +PG+     F      +    +
Sbjct: 1309 ECGGRFKGESSGRILSPGYP-FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEA 1360

Query: 218  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
            + D + +W GP    ++  + +   +  GI  + N  + ++    +F     ++ K    
Sbjct: 1361 SHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFA 1413

Query: 278  VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS 337
            ++  +         S +  C+ P   ++  R   + D   PG  V + C+PGY+L+G   
Sbjct: 1414 IQFSS---------SVATACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEER 1461

Query: 338  MRCTPQGD---WSPAAPTCEVKSCDDFMGQLLNGRVLFP--------------------- 373
            + C    +   W P+ P C      +  G   +G +L P                     
Sbjct: 1462 ITCIQVENRYFWQPSPPVCIAPCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNAD 1519

Query: 374  -------VNLQLGAKVDFVC-----DEGFQLKGSSASYCVLAGMESLWNS---------- 411
                   ++  +    DF+      D    L GS     +   +ES  N+          
Sbjct: 1520 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1579

Query: 412  ----------SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
                         + E  F P    I NG   G     +  G TV Y CD        + 
Sbjct: 1580 VSYTGFHLEYKAKLRESCFDPGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYV 1628

Query: 462  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            L G ST+ C     G   W+   P       C AP        +    + ++P   S+ +
Sbjct: 1629 LQGYSTLTCIMGDDGRPGWNRALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGH 1682

Query: 522  ECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
             C       P         V+  +S  DV +       P   + ++  ++    G  +  
Sbjct: 1683 NC-VYSIAVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPL 1738

Query: 580  SCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYG 638
            S  +G+++    ++   ++    H+  +  P      C   P    G  I      F  G
Sbjct: 1739 S--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVG 1793

Query: 639  SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            S V + CNPG      + L G  +I C +  + +  W+   P CI+P
Sbjct: 1794 SSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1834



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 104/479 (21%), Positives = 156/479 (32%), Gaps = 110/479 (22%)

Query: 69   LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128
            L ++     SGR F+I            +      C +P  P+N         Q GS I 
Sbjct: 705  LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINAR-RFGDNFQLGSSIS 753

Query: 129  YSCTKGY-RLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHY 187
              C +G+ +  G+ + TCI+    V+W    P C   PCG   +  +G  +S     ++ 
Sbjct: 754  VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG-APCGGHFSAPSGVILSPGWPGYYK 812

Query: 188  GSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP---APQCIIPNKCTPP 241
             S+         PG   +  FE           N D + +  GP   +P     N    P
Sbjct: 813  DSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVP 867

Query: 242  NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
                  L S +  ++ L      R   GF +      +   +N +          C  P 
Sbjct: 868  Q----FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 910

Query: 302  DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
              +H  R   D   FS G  V +SC+ GY L     + C     WS   PTC+     D 
Sbjct: 911  IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 967

Query: 362  MGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ----------------------- 391
             G   +G +L       +P +L     VD    +G Q                       
Sbjct: 968  RGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1025

Query: 392  ------LKGSSASYCVLAGMESLWNSSVPVCEQIF-----------------CPSPPVIP 428
                  L GS     + AG+   + + +                        C  P +  
Sbjct: 1026 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1085

Query: 429  NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
             G   G     F  G T+ ++C       + + L G S I C     G  VWS+P PRC
Sbjct: 1086 YGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEIICLGG--GRRVWSAPLPRC 1133



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 139/652 (21%), Positives = 216/652 (33%), Gaps = 142/652 (21%)

Query: 104  CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163
            C +P  P  G   +      G  + +SC+ GYRL G+S   C + G   +W    P C  
Sbjct: 1078 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC-V 1134

Query: 164  IPCGLPPTITNGDFIS----TNRENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCT 216
              CG   T   G  +S     N EN H   + + +   G G     + F L         
Sbjct: 1135 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHL--------- 1184

Query: 217  SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 276
            +  D + I+ G      +    T  ++    L S +  L+     +EF        +G +
Sbjct: 1185 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQ 1239

Query: 277  RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 336
             V          EL  C       P +        D+ +F+ G  + Y C PGY L G++
Sbjct: 1240 LVYTSF------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSS 1287

Query: 337  SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-----FPVNLQLGAKVDFVCDEG 389
             ++C    +  W    P+C  +    F G+  +GR+L     FP +  L        D G
Sbjct: 1288 LLKCMTGERRAWDYPLPSCIAECGGRFKGE-SSGRILSPGYPFPYDNNLRCMWMIEVDPG 1346

Query: 390  ------FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF- 442
                  F    + AS+ +L     +W+        +   S  +IP G H+   +    F 
Sbjct: 1347 NIVSLQFLAFDTEASHDIL----RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFD 1402

Query: 443  ----------------------------------------GKTVNYTCDPHPDRGTSFDL 462
                                                    G TV + CDP       ++L
Sbjct: 1403 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP------GYEL 1456

Query: 463  IGESTIRCTSDPQGNGVWSSPAPRC---------GILGHCQAPDHFLFAKLKTQTNASDF 513
             GE  I C    +    W    P C         G  G   +P+   F      +   D+
Sbjct: 1457 QGEERITCI-QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN---FPHPYPHSRDCDW 1512

Query: 514  PIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573
             I  +  Y     +    FSI    + ++               PD  + ++    D ++
Sbjct: 1513 TITVNADYVISLAFIS--FSIEPNYDFLY-----------IYDGPDSNSPLIGSFQDSKL 1559

Query: 574  GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633
              RI  S  T H L   S      +G    +  K     R  C  P  I NG  +     
Sbjct: 1560 PERIESSSNTMH-LAFRSDGSVSYTGFHLEYKAK----LRESCFDPGNIMNGTRLGM--- 1611

Query: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685
            ++  GS VTY C+ G      + L G  ++ C   DD    W+   P C  P
Sbjct: 1612 DYKLGSTVTYYCDAG------YVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1657



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 706 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 760
           FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 576 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 635

Query: 761 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 812
              +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 636 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 693

Query: 813 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871
             L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 694 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 730

Query: 872 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
           P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 731 PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 781

Query: 932 SPAPRCGIL--GHCQAP 946
              P+CG    GH  AP
Sbjct: 782 GLIPKCGAPCGGHFSAP 798



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%)

Query: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 1210
            FS  +V+ F CQ GF + G + + CQ  N+W   +P C     S    P   VL  +  +
Sbjct: 576  FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 635

Query: 1211 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 1262
               +N +        PG  +  S    +DL           GD SP +P     +  +  
Sbjct: 636  GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 693

Query: 1263 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 1321
              L  N  +L         +++F  D     +G + +Y      E              C
Sbjct: 694  SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 730

Query: 1322 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
            P P +  N R  G   + F  G +++  C+            G  TI C     G  +WS
Sbjct: 731  PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 781

Query: 1382 SPAPRCGIL--GHCQAP 1396
               P+CG    GH  AP
Sbjct: 782  GLIPKCGAPCGGHFSAP 798



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 70/277 (25%), Positives = 100/277 (36%), Gaps = 34/277 (12%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSTKPPICQ 1512
            C  P +P NG   + +D  +GS + +SC   + L G  S  C  ++   A WS   P+C+
Sbjct: 382  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNLGSRGRKVFELVGEPSIYCT 1566
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 441  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 498

Query: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 499  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 548

Query: 1627 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
                  +N  E E  SC     P   I  G       D FS    + + C+ G++L G  
Sbjct: 549  -----KVNYKEIEKESCGDPGTPLYGIREG-------DGFSNRDVLRFECQFGFELIGEK 596

Query: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
            S+ C     WS   P C      +F    P G VL P
Sbjct: 597  SIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSP 631



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 140/645 (21%), Positives = 212/645 (32%), Gaps = 136/645 (21%)

Query: 1810 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG 1869
            F LIGE +I C      N  WS+  P C              FP  S      +F  P+G
Sbjct: 590  FELIGEKSIVCQE----NNQWSANIPICI-------------FPCLS------NFTAPMG 626

Query: 1870 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRR-------------------KSCGPP 1910
            T L+ +   GY   +       N +W+ + D   R                   K    P
Sbjct: 627  TVLSPDYPEGYGNNL-------NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 679

Query: 1911 PEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1970
              P  G     T  +  S +  S +   RL      +    G N+T++          C 
Sbjct: 680  ESPILGTF---TGAEVPSHLT-SNSHILRLEFQADHSMSGRGFNITYNTFGHN----ECP 731

Query: 1971 PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSS 2030
             P    N   + +N   F  G+ ++  C  G       +  G  +I C   D +V +WS 
Sbjct: 732  DPGIPINARRFGDN---FQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSG 782

Query: 2031 PPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG 2090
              P+C +            I  PG   ++  +      C+        H+++  T  R+ 
Sbjct: 783  LIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS----LNCEWVIEAEPGHSIKI-TFERFQ 837

Query: 2091 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150
             +L +        P +L     L   +     Q +F S    Y L    +          
Sbjct: 838  TELNYDVLEVHDGPNLL--SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 895

Query: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 2210
             E+      SC D  G   HGR     +  +G+ VSF CD G+RL   S    +L     
Sbjct: 896  YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 950

Query: 2211 LWNSSVPVCE------------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT-HP 2257
             W+  +P C+             I  P  P         T   D+ +GK + +   T H 
Sbjct: 951  WWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL 1010

Query: 2258 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL- 2316
            +    + LI E           NG ++ P  R           PP I  G Y      L 
Sbjct: 1011 EDHHDYLLITE-----------NGSFTQPLARL-----TGSDLPPTINAGLYGNFRAQLR 1054

Query: 2317 YLPGMTISYICDPGYLLVGKGFIF--CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEM 2374
            ++   +ISY    G+ +    +    C D GI      Y   +  +F +           
Sbjct: 1055 FISDFSISY---EGFNITFSEYNLEPCEDPGI----PQYGSRIGFNFGI----------- 1096

Query: 2375 KKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTS 2417
                  GD +T  C  GY LEG+    C    R  W  PL +C +
Sbjct: 1097 ------GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1135



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 101/277 (36%), Gaps = 34/277 (12%)

Query: 554 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNAAHWSTKPPICQ 612
           C  P +P NG   + +D  +GS + +SC   + L G  S  C  ++   A WS   P+C+
Sbjct: 382 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 613 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 666
              CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 441 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 498

Query: 667 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 726
                 G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 548

Query: 727 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 786
                 +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 549 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 596

Query: 787 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823
           S+ C     WS   P C      +F   +  G VL P
Sbjct: 597 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 631



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 68/277 (24%), Positives = 101/277 (36%), Gaps = 34/277 (12%)

Query: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNAAHWSTKPPICQ 1062
            C  P +P NG   + +D  +GS + +SC   + L G  S  C  ++   A WS   P+C+
Sbjct: 382  CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440

Query: 1063 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 1116
               CG      +G F S N   F Y S      V+T   N     +  FE       Y T
Sbjct: 441  VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 498

Query: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176
                  G    P     +      P+    ++VS +  ++   +  E     GF      
Sbjct: 499  LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 548

Query: 1177 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 1236
                  +N  E E  SC     P   +       R+ D FS    + + C+ G++L G  
Sbjct: 549  -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 596

Query: 1237 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 1273
            S+ C     WS   P C      +F   +  G VL P
Sbjct: 597  SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 631



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 110/502 (21%), Positives = 165/502 (32%), Gaps = 160/502 (31%)

Query: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 1243
            E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172  ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 1244 -GDWSPAAPTCEVKSCDDFMGQLLNG------RVLFPVNLQLGAKVDF--VCDEG----- 1289
               W    P C     +D  G  + G         FP      A   +  V + G     
Sbjct: 225  TASWDFPVPICR---AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 281

Query: 1290 ----FQLKGSSASYCVLAGME--SLWNSSVPVCEQIFCPSPPVIPN-----------GRH 1332
                FQ++     Y  + G E  ++W S + +        PP+I N             H
Sbjct: 282  IFTDFQME-EKYDYLEIEGSEPPTIWLSGMNI-------PPPIISNKNWLRLHFVTDSNH 333

Query: 1333 TGKPLEV-FPFGKAVNYTCD-----PHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPR 1386
              +     +   KA+++        P  D    F ++ E  I+  S+   +        R
Sbjct: 334  RYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKR 393

Query: 1387 CGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR-PFSITCLD----NLV 1441
             G                      SDF +G+++++ C  +Y  +   SITC         
Sbjct: 394  IG----------------------SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 431

Query: 1442 WSSPKDVCKRKSCKTPPDPVNG----------------MVHVIT---------------D 1470
            WS  + VCK K+C +     +G                 V VIT               D
Sbjct: 432  WSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFD 491

Query: 1471 IQV---------GSRINYSCTTGHRLIGHSSAECILSGNTAHW---STKPPI-------- 1510
            +++         G  +    T    L G    + I+S ++  W    T   +        
Sbjct: 492  LEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 551

Query: 1511 ---CQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1563
                ++  CG P T    I  GD  S NR+      V+ + C  G      FEL+GE SI
Sbjct: 552  YKEIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIGEKSI 598

Query: 1564 YCTSNDDQVGIWSGPAPQCIIP 1585
             C  N+     WS   P CI P
Sbjct: 599  VCQENNQ----WSANIPICIFP 616



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 187/905 (20%), Positives = 284/905 (31%), Gaps = 270/905 (29%)

Query: 825  NLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 883
            +  LG+ V F CDE + L+G+ +  C  +A + + W+   PVC+   C S    P+G  T
Sbjct: 397  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 456

Query: 884  GKPLEVFPFGKTVNYTC----------DPHPDRGTSFDL-IGESTIRCTSDPQGNGVWSS 932
                  FPF    N  C                   FDL IG  T+         G    
Sbjct: 457  SPN---FPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGD----GGEVGD 509

Query: 933  PAPRCGILGHCQAPDHFLFAK----LKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
            P     +L     PD  +       L  QT+ S   +G  + Y                 
Sbjct: 510  PRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY----------------- 552

Query: 989  NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 1048
                   K++ +++SC  P  P+ G +           + + C  G  LIG  S  C  +
Sbjct: 553  -------KEI-EKESCGDPGTPLYG-IREGDGFSNRDVLRFECQFGFELIGEKSIVCQEN 603

Query: 1049 GNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELV 1108
                 WS   PIC   PC    T   G  +S +           Y    G+    ++ ++
Sbjct: 604  N---QWSANIPIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTII 648

Query: 1109 GEPS--IYCTSND-------DQVGIWSGPAPQCII------------------------- 1134
             +P   I+ + ND       D + +  G +P+  I                         
Sbjct: 649  SDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQ 708

Query: 1135 ------------------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKG 1174
                               N+C  P +  N     DN   F L   +   C+ GF+  +G
Sbjct: 709  ADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQG 765

Query: 1175 PRRVKCQALN---KWEPELPSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFY--- 1224
               + C  ++    W   +P C   C      P  V+            SPG   +Y   
Sbjct: 766  TETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDS 814

Query: 1225 -SCEPGYDLRGAASMRCT-PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 1282
             +CE   +     S++ T  +          EV    + +  LL       V   L +  
Sbjct: 815  LNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSS 874

Query: 1283 DFV-----CDEGFQLKGSSASY-CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336
            +F+      D      G    Y  V     S  +  +PV             +GR  G  
Sbjct: 875  NFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPV-------------HGRRYGHD 921

Query: 1337 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQ 1394
               F  G  V+++CD      + + L  E  + C    + N  WS P P C  L  G  +
Sbjct: 922  ---FSIGSTVSFSCD------SGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVR 968

Query: 1395 APDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSC 1454
             P                   GT L     PE+Y  P S+ C     W+           
Sbjct: 969  GPS------------------GTILS-PGYPEFY--PNSLNC----TWT----------- 992

Query: 1455 KTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRI 1514
                           D+  G  + ++  T H L  H     I    T + S   P+ +  
Sbjct: 993  --------------VDVTHGKGVQFNFHTFH-LEDHHDYLLI----TENGSFTQPLARLT 1033

Query: 1515 PCGLPPTIANGDF------------ISTNRENFH------------------YGSVVTYR 1544
               LPPTI  G +             S + E F+                  YGS + + 
Sbjct: 1034 GSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFN 1093

Query: 1545 CNLGS----RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 1600
              +G          + L G   I C     +V  WS P P+C+     +  N E GIL+S
Sbjct: 1094 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV--WSAPLPRCVAECGASATNNE-GILLS 1150

Query: 1601 DNRSL 1605
             N  L
Sbjct: 1151 PNYPL 1155



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 103  SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
            +CR+P  P+NG  +   G + G  + + C  GY L G    TCI   +   W    P+C 
Sbjct: 1423 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC- 1480

Query: 163  RIPCGLPPTITNGDFISTN 181
              PCG   T ++G  +S N
Sbjct: 1481 IAPCGGNLTGSSGFILSPN 1499



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 112/503 (22%), Positives = 165/503 (32%), Gaps = 162/503 (32%)

Query: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 343
           E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 344 -GDWSPAAPTCEVKSCDDFMGQLLNG------RVLFPVNLQLGAKVDF--VCDEG----- 389
              W    P C     +D  G  + G         FP      A   +  V + G     
Sbjct: 225 TASWDFPVPICR---AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 281

Query: 390 ----FQLKGSSASYCVLAGME--SLWNSSVPVCEQIFCPSPPVIPNG------------- 430
               FQ++     Y  + G E  ++W S + +        PP+I N              
Sbjct: 282 IFTDFQME-EKYDYLEIEGSEPPTIWLSGMNI-------PPPIISNKNWLRLHFVTDSNH 333

Query: 431 --RHTGKPLEV---FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAP 485
             R    P +V     F K+  +   P  D    F ++ E  I+  S+   +        
Sbjct: 334 RYRGFSAPYQVKKAIDF-KSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGK 392

Query: 486 RCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR-PFSITCLD----NL 540
           R G                      SDF +G+++++ C  +Y  +   SITC        
Sbjct: 393 RIG----------------------SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFA 430

Query: 541 VWSSPKDVCKRKSCKTPPDPVNG----------------MVHVIT--------------- 569
            WS  + VCK K+C +     +G                 V VIT               
Sbjct: 431 AWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEF 490

Query: 570 DIQV---------GSRINYSCTTGHRLIGHSSAECILSGNAAHW---STKPPI------- 610
           D+++         G  +    T    L G    + I+S ++  W    T   +       
Sbjct: 491 DLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 550

Query: 611 ----CQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 662
                ++  CG P T    I  GD  S NR+      V+ + C  G      FEL+GE S
Sbjct: 551 NYKEIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIGEKS 597

Query: 663 IYCTSNDDQVGIWSGPAPQCIIP 685
           I C  N+     WS   P CI P
Sbjct: 598 IVCQENNQ----WSANIPICIFP 616



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 112/503 (22%), Positives = 165/503 (32%), Gaps = 162/503 (32%)

Query: 737  EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 793
            E +  SC     PP  VL+  R       F  G ++ YSC  GY L G   + C      
Sbjct: 172  ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224

Query: 794  -GDWSPAAPTCEVKSCDDFMGQLLNG------RVLFPVNLQLGAKVDF--VCDEG----- 839
               W    P C     +D  G  + G         FP      A   +  V + G     
Sbjct: 225  TASWDFPVPICR---AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 281

Query: 840  ----FQLKGSSASYCVLAGME--SLWNSSVPVCEQIFCPSPPVIPNG------------- 880
                FQ++     Y  + G E  ++W S + +        PP+I N              
Sbjct: 282  IFTDFQME-EKYDYLEIEGSEPPTIWLSGMNI-------PPPIISNKNWLRLHFVTDSNH 333

Query: 881  --RHTGKPLEV---FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAP 935
              R    P +V     F K+  +   P  D    F ++ E  I+  S+   +        
Sbjct: 334  RYRGFSAPYQVKKAIDF-KSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGK 392

Query: 936  RCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR-PFSITCLD----NL 990
            R G                      SDF +G+++++ C  +Y  +   SITC        
Sbjct: 393  RIG----------------------SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFA 430

Query: 991  VWSSPKDVCKRKSCKTPPDPVNG----------------MVHVIT--------------- 1019
             WS  + VCK K+C +     +G                 V VIT               
Sbjct: 431  AWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEF 490

Query: 1020 DIQV---------GSRINYSCTTGHRLIGHSSAECILSGNAAHW---STKPPI------- 1060
            D+++         G  +    T    L G    + I+S ++  W    T   +       
Sbjct: 491  DLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 550

Query: 1061 ----CQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112
                 ++  CG P T    I  GD  S NR+      V+ + C  G      FEL+GE S
Sbjct: 551  NYKEIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIGEKS 597

Query: 1113 IYCTSNDDQVGIWSGPAPQCIIP 1135
            I C  N+     WS   P CI P
Sbjct: 598  IVCQENNQ----WSANIPICIFP 616



 Score = 41.6 bits (96), Expect = 0.010
 Identities = 57/260 (21%), Positives = 99/260 (38%), Gaps = 43/260 (16%)

Query: 1866 FPVGTSLNYECRPGYFGKMF-SISCLENLV----WSSVEDNCRRK-SCGPPPEPFNGMVH 1919
            F VG  + Y C  GY       ++C+ N V    W      CR + +CG      +G++ 
Sbjct: 194  FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII- 252

Query: 1920 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP------- 1972
              +   F +  + + +  + ++  P  T  +   +   ++K    EI   EPP       
Sbjct: 253  --SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 310

Query: 1973 ----PTISNGDFY-------SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
                P ISN ++        SN+R   + G    YQ     D    F+  G +       
Sbjct: 311  NIPPPIISNKNWLRLHFVTDSNHR---YRGFSAPYQVKKAID----FKSRGFKLFPGKDN 363

Query: 2022 DDQVGVWSSPPPRCISTNKCTAP-EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
             ++  + +    +  S N C  P E EN  R+  +   F+L   ++F C   +V+ G+ +
Sbjct: 364  SNKFSILNEGGIKTAS-NLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKS 419

Query: 2081 VQCQ----TNGRWGPKLPHC 2096
            + CQ        W    P C
Sbjct: 420  ITCQRIAEVFAAWSDHRPVC 439



 Score = 38.9 bits (89), Expect = 0.064
 Identities = 146/721 (20%), Positives = 228/721 (31%), Gaps = 238/721 (33%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQ--IKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
            ++SC +P  P+ G   + +G  F ++  +++ C  G+ LIG  S  C  +     W    
Sbjct: 557  KESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ---WSANI 610

Query: 159  PICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCT 216
            PIC   PC    T   G  +S +           Y    G+    ++ ++ +P   I+ +
Sbjct: 611  PIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTIISDPGSRIHLS 658

Query: 217  SND-------DQVGIWSGPAPQCII----------------------------------- 234
             ND       D + +  G +P+  I                                   
Sbjct: 659  FNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 718

Query: 235  --------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPRRVKCQALN 284
                     N+C  P +  N     DN   F L   +   C+ GF+  +G   + C  ++
Sbjct: 719  NITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMD 775

Query: 285  ---KWEPELPSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFY----SCEPGYDLR 333
                W   +P C   C      P  V+            SPG   +Y    +CE   +  
Sbjct: 776  GKVMWSGLIPKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDSLNCEWVIEAE 824

Query: 334  GAASMRCT-PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-----CD 387
               S++ T  +          EV    + +  LL       V   L +  +F+      D
Sbjct: 825  PGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTD 884

Query: 388  EGFQLKGSSASY-CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTV 446
                  G    Y  V     S  +  +PV             +GR  G     F  G TV
Sbjct: 885  NSRSNNGFKIHYESVTVNTYSCLDPGIPV-------------HGRRYGHD---FSIGSTV 928

Query: 447  NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKL 504
            +++CD      + + L  E  + C    + N  WS P P C  L  G  + P        
Sbjct: 929  SFSCD------SGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVRGPS------- 971

Query: 505  KTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 564
                       GT L     PE+Y  P S+ C     W+                     
Sbjct: 972  -----------GTILS-PGYPEFY--PNSLNC----TWT--------------------- 992

Query: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN 624
                 D+  G  + ++  T H    H       +G     S   P+ +     LPPTI  
Sbjct: 993  ----VDVTHGKGVQFNFHTFHLEDHHDYLLITENG-----SFTQPLARLTGSDLPPTINA 1043

Query: 625  G---------DFIST-----------------------------NRENFHY--GSVVTYR 644
            G          FIS                              +R  F++  G  +T+ 
Sbjct: 1044 GLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFS 1103

Query: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRS 704
            C+ G      + L G   I C     +V  WS P P+C+     +  N E GIL+S N  
Sbjct: 1104 CSSG------YRLEGTSEIICLGGGRRV--WSAPLPRCVAECGASATNNE-GILLSPNYP 1154

Query: 705  L 705
            L
Sbjct: 1155 L 1155



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 7/66 (10%)

Query: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTD----QGIWSQLDHY 2353
            CP P + +NG  IG   SL   G T+ + CD  Y+L G   I C         WS     
Sbjct: 382  CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 438

Query: 2354 CKEVNC 2359
            CK   C
Sbjct: 439  CKVKTC 444



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 2178 NLQLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC 2224
            +  LG+ V F CDE + L+G  +  C  +A + A W+   PVC+   C
Sbjct: 397  DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 2378 YHYGDYVTLKCEDGYTLEGSPWSQCQADD--RWDPPLAKCTSRTHDAL 2423
            Y  GD V+ +C+ GY+L+G     C      RW+ P+  C ++   A+
Sbjct: 1964 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2011



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
           Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 672 VGIWSGPAPQCIIPNKC 688
              W  P P C   + C
Sbjct: 225 TASWDFPVPICRAEDAC 241



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 1122 VGIWSGPAPQCIIPNKC 1138
               W  P P C   + C
Sbjct: 225  TASWDFPVPICRAEDAC 241



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%)

Query: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
            Q   CG P     G    T    F  G  + Y C  G      + L G P + C +N   
Sbjct: 174  QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 224

Query: 1572 VGIWSGPAPQCIIPNKC 1588
               W  P P C   + C
Sbjct: 225  TASWDFPVPICRAEDAC 241


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  354 bits (908), Expect = 7e-97
 Identities = 361/1371 (26%), Positives = 541/1371 (39%), Gaps = 210/1371 (15%)

Query: 102  KSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC 161
            ++C +PP   NG + +      G  + + C  GY LIG    TC   G    W+   P C
Sbjct: 2086 QNCPDPPPFQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTCQ-HGINRNWNYPFPRC 2143

Query: 162  DRIPCGLPPTITNGDFISTNRENFH---YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
            D  PCG   T  NG   S    + +      +      PG G    F L+   ++     
Sbjct: 2144 DA-PCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAV----- 2197

Query: 219  DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---FSLNEVVEFRCQPGFVMKGP 275
            +D + +W GP             + + G+  S N +L   +S    V  +    F   G 
Sbjct: 2198 NDYIAVWDGPDQN----------SPQLGVF-SGNTALETAYSSTNQVLLKFHSDFSNGGF 2246

Query: 276  RRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
              +   A            + CQPPP V  AE    D D+F  G  V Y C PGY L G 
Sbjct: 2247 FVLNFHAFQL---------KKCQPPPAVPQAEMLTED-DDFEIGDFVKYQCHPGYTLVGT 2296

Query: 336  ASMRC--TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP-------------------V 374
              + C  + Q  +  + PTCE +   + +    +G +L P                    
Sbjct: 2297 DILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEP 2356

Query: 375  NLQLGAKVD-FVCDEGFQL-------KGSSASYCVLAGMESLWNSSVPVCEQIF------ 420
            N  +   VD F  ++ F          G S    VL+G  +  ++      Q++      
Sbjct: 2357 NYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTD 2416

Query: 421  ----------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464
                            C     + NG    +       G  V+Y C P       + ++G
Sbjct: 2417 HATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAV--GSKVHYFCKP------GYRMVG 2468

Query: 465  ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECR 524
             S   C  +P G   W S  P C  +  C  P+    +        ++F + + + YEC 
Sbjct: 2469 HSNATCRRNPLGMYQWDSLTPLCQAVS-CGIPE----SPGNGSFTGNEFTLDSKVVYECH 2523

Query: 525  PEYY---GRPFSITCLDNLVWSSP--KDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
              +     +  +  C ++ +WS+      CK  +C  P        HVI  +  GS   Y
Sbjct: 2524 EGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIEAQLSEHVIWRLVSGSLNEY 2581

Query: 580  ------SCTTGHRLIGHSSAECILSGNAAHWST--KPPICQRIPCGLPPTIANGDFISTN 631
                  SC+ G+ L G     C  +G    W+   + P C+ I CG      NG+ I T 
Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANGT---WNIGDERPSCRVISCGSLSFPPNGNKIGTL 2638

Query: 632  RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 691
                 YG+   + CN G      + LVG     C +N    G+WSG   +C+  +  +P 
Sbjct: 2639 TV---YGATAIFTCNTG------YTLVGSHVRECLAN----GLWSGSETRCLAGHCGSPD 2685

Query: 692  NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 750
             + NG +  D    FS  + V ++C PGF + G     C   +KW  + P C  + C  P
Sbjct: 2686 PIVNGHISGDG---FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHP 2742

Query: 751  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 810
             +  H      +   F+    V ++C  GY L+G +  +C   G WS   PTC V +C D
Sbjct: 2743 GNPAHGFTNGSE---FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSD 2799

Query: 811  ---FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867
                   + +G+  FP + + G  + + C +GF L GSSA  C+  G   LW+ S+P C 
Sbjct: 2800 PGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCL 2856

Query: 868  QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGN 927
             I C  P V  N   TG   E+F +G  V+Y+C     RG+   LIG  T  C  D    
Sbjct: 2857 AISCGHPGVPANAVLTG---ELFTYGAVVHYSC-----RGSE-SLIGNDTRVCQEDSH-- 2905

Query: 928  GVWSSPAPRC-----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GR 980
              WS   P C     G  G    P H             DF   + L++ C   +   G 
Sbjct: 2906 --WSGALPHCTGNNPGFCGDPGTPAH-------GSRLGDDFKTKSLLRFSCEMGHQLRGS 2956

Query: 981  PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1040
            P   TCL N  WS  + VC+  SC  P  P NGM+     I   S + Y+C  G++  G 
Sbjct: 2957 P-ERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGL 3015

Query: 1041 SSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSG 1100
             +  C  +G    W+   P C  I CG P T+ANG    T   +F +   V+Y+CNPG  
Sbjct: 3016 MTRHCTANGT---WTGTAPDCTIISCGDPGTLANGIQFGT---DFTFNKTVSYQCNPG-- 3067

Query: 1101 GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNE 1160
               V E V   +I CT +    G W+   P C       PP V+NG +   +   F    
Sbjct: 3068 --YVMEAVTSATIRCTKD----GRWNPSKPVCKAVLCPQPPPVQNGTVEGSD---FRWGS 3118

Query: 1161 VVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ 1220
             + + C  G+ +     + C+    W+ E+P C  V    P +  AE     K +F+   
Sbjct: 3119 SISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGI-PAEGRLSGK-SFTYKS 3176

Query: 1221 EVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC---EVKSCDDFMGQLLNGRVLFPVNLQ 1277
            EVF+ C+  + L G++   C   G WS   PTC      +C D  G    G        +
Sbjct: 3177 EVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD-PGTPHFGIQNSSRGYE 3235

Query: 1278 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 1337
            +G+ V F C +G+ ++GS+   C LA +   W+     C    C  P    +     + +
Sbjct: 3236 VGSTVFFRCRKGYHIQGSTTRTC-LANL--TWSGIQTECIPHACRQPETPAHA--DVRAI 3290

Query: 1338 EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAPRC 1387
            ++  FG  + YTC P       F L G S  R C +D +    W+  +P C
Sbjct: 3291 DLPTFGYTLVYTCHP------GFFLAGGSEHRTCKADMK----WTGKSPVC 3331



 Score =  345 bits (885), Expect = 3e-94
 Identities = 367/1371 (26%), Positives = 544/1371 (39%), Gaps = 205/1371 (14%)

Query: 1002 KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 1061
            ++C  PP   NG + + +D  VG  +++ C  G+ LIGH    C   G   +W+   P C
Sbjct: 2086 QNCPDPPPFQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTC-QHGINRNWNYPFPRC 2143

Query: 1062 QRIPCGLPPTIANGDFISTNRENFH---YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 1118
               PCG   T  NG   S    + +      +      PG G    F L+   ++     
Sbjct: 2144 DA-PCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAV----- 2197

Query: 1119 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---FSLNEVVEFRCQPGFVMKGP 1175
            +D + +W GP             + + G+  S N +L   +S    V  +    F   G 
Sbjct: 2198 NDYIAVWDGPDQN----------SPQLGVF-SGNTALETAYSSTNQVLLKFHSDFSNGGF 2246

Query: 1176 RRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 1235
              +   A            + CQPPP V  AE    D D+F  G  V Y C PGY L G 
Sbjct: 2247 FVLNFHAFQL---------KKCQPPPAVPQAEMLTED-DDFEIGDFVKYQCHPGYTLVGT 2296

Query: 1236 ASMRC--TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP-------------------V 1274
              + C  + Q  +  + PTCE +   + +    +G +L P                    
Sbjct: 2297 DILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEP 2356

Query: 1275 NLQLGAKVD-FVCDEGFQL-------KGSSASYCVLAGMESLWNSSVPVCEQIF------ 1320
            N  +   VD F  ++ F          G S    VL+G  +  ++      Q++      
Sbjct: 2357 NYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTD 2416

Query: 1321 ----------------CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIG 1364
                            C     + NG    +       G  V+Y C P       + ++G
Sbjct: 2417 HATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAV--GSKVHYFCKP------GYRMVG 2468

Query: 1365 ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECR 1424
             S   C  +P G   W S  P C  +  C  P+    +        ++F + + + YEC 
Sbjct: 2469 HSNATCRRNPLGMYQWDSLTPLCQAVS-CGIPE----SPGNGSFTGNEFTLDSKVVYECH 2523

Query: 1425 PEYY---GRPFSITCLDNLVWSSP--KDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 1479
              +     +  +  C ++ +WS+      CK  +C  P        HVI  +  GS   Y
Sbjct: 2524 EGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIEAQLSEHVIWRLVSGSLNEY 2581

Query: 1480 ------SCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1533
                  SC+ G+ L G     C  +G T +   + P C+ I CG      NG+ I T   
Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANG-TWNIGDERPSCRVISCGSLSFPPNGNKIGTLTV 2640

Query: 1534 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1593
               YG+   + CN G      + LVG     C +N    G+WSG   +C+  +  +P  +
Sbjct: 2641 ---YGATAIFTCNTG------YTLVGSHVRECLAN----GLWSGSETRCLAGHCGSPDPI 2687

Query: 1594 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPE 1652
             NG +  D    FS  + V ++C PGF + G     C   +KW  + P C  + C  P  
Sbjct: 2688 VNGHISGDG---FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGN 2744

Query: 1653 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD-- 1710
              HG    S    F+    V ++C  GY L+G +   C   G WS   P C V +C D  
Sbjct: 2745 PAHGFTNGSE---FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPG 2801

Query: 1711 -FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI 1769
                 + HG+  FP + + G  + + C +GF L GSS   C+  G   LW+ S+P C  I
Sbjct: 2802 FVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCLAI 2858

Query: 1770 FCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGV 1829
             C +P    N   TG       YG  + Y+C     RG   +LIG  T  C  D H    
Sbjct: 2859 SCGHPGVPANAVLTGEL---FTYGAVVHYSC-----RGSE-SLIGNDTRVCQEDSH---- 2905

Query: 1830 WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY-FGKMFSIS 1888
            WS   P C  +   G C  P      S    + D +F   + L + C  G+        +
Sbjct: 2906 WSGALPHCTGN-NPGFCGDPGTPAHGSR---LGD-DFKTKSLLRFSCEMGHQLRGSPERT 2960

Query: 1889 CLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTC 1948
            CL N  WS ++  C   SCG P  P NGM+  +    F S+V Y+C EG++  G  +  C
Sbjct: 2961 CLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHC 3020

Query: 1949 LVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLF 2008
              +G   TW   AP C IISC  P T++NG  +    T F     V+YQC+ G     + 
Sbjct: 3021 TANG---TWTGTAPDCTIISCGDPGTLANGIQFG---TDFTFNKTVSYQCNPG----YVM 3070

Query: 2009 ELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFR 2068
            E V   +I CT KD   G W+   P C +      P V+N   V G  S F     I + 
Sbjct: 3071 EAVTSATIRCT-KD---GRWNPSKPVCKAVLCPQPPPVQNG-TVEG--SDFRWGSSISYS 3123

Query: 2069 CQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYS 2128
            C  G+ +  S  + C+  G W  ++P C  V    P I   E  LS + +F+   EVF+ 
Sbjct: 3124 CMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGI-PAEGRLSGK-SFTYKSEVFFQ 3181

Query: 2129 CEPSYDLRGAASLHCTPQGDWSPEAPRC---TVKSCDDFLGQLPH-GRVLLPLNLQLGAK 2184
            C+  + L G++   C   G WS   P C      +C D     PH G        ++G+ 
Sbjct: 3182 CKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD--PGTPHFGIQNSSRGYEVGST 3239

Query: 2185 VSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFC--PNPPAILNGRHTGTPFGD 2242
            V F C +G+ ++G +   C+       W+     C    C  P  PA     H      D
Sbjct: 3240 VFFRCRKGYHIQGSTTRTCL---ANLTWSGIQTECIPHACRQPETPA-----HADVRAID 3291

Query: 2243 IP-YGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCE 2291
            +P +G  + Y C  HP     F L G S  R C +D +    W+  +P C+
Sbjct: 3292 LPTFGYTLVYTC--HPG----FFLAGGSEHRTCKADMK----WTGKSPVCK 3332



 Score =  344 bits (883), Expect = 5e-94
 Identities = 458/1990 (23%), Positives = 719/1990 (36%), Gaps = 422/1990 (21%)

Query: 688  CTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK---WEPELPSC 743
            C  P + +NG    D+R      + V F+C PG+ ++G  ++ C  LN    W+P+ P+C
Sbjct: 1392 CNDPGMPQNGTRYGDSREA---GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448

Query: 744  SRVCQ-----PPPDVLHAERTQRDKDNFSPGQE---------------VF--YSCEPGYD 781
               C      P   +L     Q     + PG+E               +F  ++ EP YD
Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQP----YPPGKECDWRVKVNPDFVIALIFKSFNMEPSYD 1504

Query: 782  LR-------GAASMRCTPQGDWSP----------------------AAPTCEVK-----S 807
                       + +  + QG  +P                      +    E K     +
Sbjct: 1505 FLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREA 1564

Query: 808  CDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL-AGMESLWNSSVPVC 866
            C D  G ++NG  +   + +LG+ + + CD G+++   S+  CV+ A  +  W+  +P C
Sbjct: 1565 CFD-PGNIMNGTRV-GTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622

Query: 867  EQIFCPSPPVIPNGRHTGKPLEV----FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTS 922
                 P       G++TG    V    +P   T    C         F + G+     T+
Sbjct: 1623 N---APC-----GGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTA 1674

Query: 923  DPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS----LKYECRPEYY 978
                  ++           H QA    L + L    +    P+ TS    L++  +    
Sbjct: 1675 LNDLAELFDGT--------HAQAR---LLSSLSGSHSGETLPLATSNQILLRFSAKSGAS 1723

Query: 979  GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLI 1038
             R F       +  + P+       C + P+P  G   + ++   GS + + C  G+ L 
Sbjct: 1724 ARGFHF-----VYQAVPRT--SDTQCSSVPEPRYGR-RIGSEFSAGSIVRFECNPGYLLQ 1775

Query: 1039 GHSSAECILSGNA-AHWSTKPPICQRIPCGLPPTIANGDFIST-------NRENFHYGSV 1090
            G ++  C    NA A W+   P C  +PC    T   G  +S        N  N  +  +
Sbjct: 1776 GSTALHCQSVPNALAQWNDTIPSCV-VPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKII 1834

Query: 1091 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG---PAPQCIIPNKCTPPNVENGI 1147
            VT     GSG +     +   S     N D + I  G    AP+    +  T P + N  
Sbjct: 1835 VT----EGSGIQ-----IQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNS- 1884

Query: 1148 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAE 1207
              S+   L   +++           K      CQ     EP LPS S             
Sbjct: 1885 -TSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQ-----EPALPSNSI------------ 1926

Query: 1208 RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG--DWSPAAPTCEVKSCDDFMGQL 1265
               +  D +     + + CEPGY L+G + + C P     W+  +P C + +C   +  L
Sbjct: 1927 ---KIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-IATCGGTLSTL 1982

Query: 1266 LNGRVL-------FPVNLQL----------GAKVDFV-----CDEGF------------- 1290
              G +L       +P NL            GA + F+      +  F             
Sbjct: 1983 -GGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPM 2041

Query: 1291 --QLKGSSASYCVLAGMESL--------------WNSSVPVCEQIFCPSPPVIPNGRHTG 1334
              Q  G+     +L+                   +  +    E   CP PP   NG    
Sbjct: 2042 IGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYMIN 2101

Query: 1335 KPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQ 1394
                V   G++V++ C P       + LIG   + C      N  W+ P PR      C 
Sbjct: 2102 SDYSV---GQSVSFECYP------GYILIGHPVLTCQHGINRN--WNYPFPR------CD 2144

Query: 1395 APDHFLFAKLKTQTNASDFPIGTSLKYECR-----PEYYGRPFSITCLDN-------LVW 1442
            AP  +          +  FP    +  +C      P  +G   + T L          VW
Sbjct: 2145 APCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVW 2204

Query: 1443 SSPKD-------------------------------------------VCKRKSCKTPPD 1459
              P                                               + K C+ PP 
Sbjct: 2205 DGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPA 2264

Query: 1460 -PVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGL 1518
             P   M+    D ++G  + Y C  G+ L+G     C LS       + P    + P   
Sbjct: 2265 VPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCPANE 2324

Query: 1519 PPTIANGDFISTNRENFHYGS------------------VVTYRCNL---------GSRG 1551
              T ++G  +S      ++ S                  V T++            GS G
Sbjct: 2325 VRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSG 2384

Query: 1552 RKVFELV-----GEPSIYCTSNDDQVGIWSGP-------------APQCIIPNKCTPPNV 1593
            +    +V      E S + + ++     WS               AP C +    T P  
Sbjct: 2385 QSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSL----THPLK 2440

Query: 1594 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ----ALNKWEPELPSCSRV-CQ 1648
              GIL   NR+  ++   V + C+PG+ M G     C+     + +W+   P C  V C 
Sbjct: 2441 NGGIL---NRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCG 2497

Query: 1649 PPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA--ASLHCTPQGDWSPEA--PRCA 1704
             P    +G  T +    F+   +V Y C  G+ L  +  A+  C   G WS +   P C 
Sbjct: 2498 IPESPGNGSFTGNE---FTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCK 2554

Query: 1705 VKSCDDFLGQLPHG---RVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWN- 1760
              +C     QL      R++     + GA+V   C  G+ L+G  +  C   G    WN 
Sbjct: 2555 PVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGT---WNI 2611

Query: 1761 -NSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
             +  P C  I C +     NG   GT +    YG    +TC+        + L+G     
Sbjct: 2612 GDERPSCRVISCGSLSFPPNGNKIGTLT---VYGATAIFTCNTG------YTLVGSHVRE 2662

Query: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPG 1879
            C +    NG+WS    RC     AGHC +P+  P  +  I  + F +    ++ Y+C PG
Sbjct: 2663 CLA----NGLWSGSETRC----LAGHCGSPD--PIVNGHISGDGFSYR--DTVVYQCNPG 2710

Query: 1880 YFGKMFSIS-CLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGF 1938
            +     S+  CL++  WS     C   +CG P  P +G  +  ++      VN++CN G+
Sbjct: 2711 FRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTN-GSEFNLNDVVNFTCNTGY 2769

Query: 1939 RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS--NNRTSFHNGTVVTY 1996
             L G     C  +G    W    P C +++C  P  + N   +   N   SF  G  + Y
Sbjct: 2770 LLQGVSRAQCRSNGQ---WSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILY 2826

Query: 1997 QCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNR 2056
             C  G      F L+G  ++ C +     G+W    P+C++ + C  P V     + G  
Sbjct: 2827 HCKKG------FYLLGSSALTCMAN----GLWDRSLPKCLAIS-CGHPGVPANAVLTGE- 2874

Query: 2057 SFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR----VCQPPPEILHGEHT 2112
              FT   ++ + C+    ++G+ T  CQ +  W   LPHC+      C  P    HG   
Sbjct: 2875 -LFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRL 2933

Query: 2113 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGR 2172
                D+F     + +SCE  + LRG+    C   G WS   P C   SC +  G   +G 
Sbjct: 2934 ---GDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGN-PGTPTNGM 2989

Query: 2173 VLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 2232
            ++    +   + V + C EG++  G    HC   G    W  + P C  I C +P  + N
Sbjct: 2990 IVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGT---WTGTAPDCTIISCGDPGTLAN 3046

Query: 2233 GRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCEL 2292
            G   GT   D  + K +SY C+     G     +  ++IRCT D    G W+   P C+ 
Sbjct: 3047 GIQFGT---DFTFNKTVSYQCNP----GYVMEAVTSATIRCTKD----GRWNPSKPVCKA 3095

Query: 2293 SVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDH 2352
             +   CP PP +QNG   G   S +  G +ISY C  GY L     + C  +G+W     
Sbjct: 3096 VL---CPQPPPVQNGTVEG---SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIP 3149

Query: 2353 YCKEVNCSFPLFMNGISKELEMK-KVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPP 2411
             C  V C  P    GI  E  +  K + Y   V  +C+  + L GS    CQAD  W   
Sbjct: 3150 QCLPVFCGDP----GIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGI 3205

Query: 2412 LAKCTSRTHD 2421
               C    H+
Sbjct: 3206 QPTCIDPAHN 3215



 Score =  323 bits (828), Expect = 1e-87
 Identities = 284/982 (28%), Positives = 414/982 (42%), Gaps = 121/982 (12%)

Query: 562  NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH-WSTKPPICQRIPCGLPP 620
            NG +   T   VGS+++Y C  G+R++GHS+A C  +    + W +  P+CQ + CG+P 
Sbjct: 2441 NGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPE 2500

Query: 621  TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWS--GP 678
            +  NG F       F   S V Y C+ G      F+L  E S   T+   + G+WS  G 
Sbjct: 2501 SPGNGSFTG---NEFTLDSKVVYECHEG------FKL--ESSQQATAVCQEDGLWSNKGK 2549

Query: 679  APQCIIPNKCTPPNVENGI-------LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731
             P C  P  C  P++E  +       LVS   SL      V   C PG+ ++G R ++CQ
Sbjct: 2550 PPTC-KPVAC--PSIEAQLSEHVIWRLVSG--SLNEYGAQVLLSCSPGYYLEGWRLLRCQ 2604

Query: 732  ALNKWE--PELP-----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 784
            A   W    E P     SC  +  PP        T         G    ++C  GY L G
Sbjct: 2605 ANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVY-------GATAIFTCNTGYTLVG 2657

Query: 785  AASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKG 844
            +    C   G WS +   C    C      ++NG +           V + C+ GF+L G
Sbjct: 2658 SHVRECLANGLWSGSETRCLAGHCGS-PDPIVNGHISGD-GFSYRDTVVYQCNPGFRLVG 2715

Query: 845  SSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHP 904
            +S   C+    +  W+   PVC  I C  P    +G   G     F     VN+TC+   
Sbjct: 2716 TSVRICL---QDHKWSGQTPVCVPITCGHPGNPAHGFTNGSE---FNLNDVVNFTCN--- 2766

Query: 905  DRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN-ASDF 963
               T + L G S  +C S    NG WSSP P C ++ +C  P     A    Q N    F
Sbjct: 2767 ---TGYLLQGVSRAQCRS----NGQWSSPLPTCRVV-NCSDPGFVENAIRHGQQNFPESF 2818

Query: 964  PIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD-- 1020
              G S+ Y C+  +Y    S +TC+ N +W      C   SC  P  P N    V+T   
Sbjct: 2819 EYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANA---VLTGEL 2875

Query: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP---CGLPPTIANGDF 1077
               G+ ++YSC     LIG+ +  C      +HWS   P C       CG P T A+G  
Sbjct: 2876 FTYGAVVHYSCRGSESLIGNDTRVC---QEDSHWSGALPHCTGNNPGFCGDPGTPAHGSR 2932

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
            +    ++F   S++ + C  G       +L G P   C  N    G WSG  P C   + 
Sbjct: 2933 LG---DDFKTKSLLRFSCEMG------HQLRGSPERTCLLN----GSWSGLQPVCEAVSC 2979

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
              P    NG++VS +  LFS +  V + C  G+   G     C A   W    P C+ + 
Sbjct: 2980 GNPGTPTNGMIVSSDGILFSSS--VIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIIS 3037

Query: 1198 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWSPAAPTCEV 1255
               P  L A   Q   D F+  + V Y C PGY +    +A++RCT  G W+P+ P C+ 
Sbjct: 3038 CGDPGTL-ANGIQFGTD-FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKA 3095

Query: 1256 KSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 1315
              C      + NG V    + + G+ + + C +G+QL  S+   C   G   +W   +P 
Sbjct: 3096 VLCPQ-PPPVQNGTV-EGSDFRWGSSISYSCMDGYQLSHSAILSCEGRG---VWKGEIPQ 3150

Query: 1316 CEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQ 1375
            C  +FC  P +   GR +GK    F +   V + C       + F L+G S   C    Q
Sbjct: 3151 CLPVFCGDPGIPAEGRLSGKS---FTYKSEVFFQCK------SPFILVGSSRRVC----Q 3197

Query: 1376 GNGVWSSPAPRCGILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRP 1431
             +G WS   P C    H   PD    HF       Q ++  + +G+++ + CR  Y+ + 
Sbjct: 3198 ADGTWSGIQPTCIDPAHNTCPDPGTPHF-----GIQNSSRGYEVGSTVFFRCRKGYHIQG 3252

Query: 1432 FSI-TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1490
             +  TCL NL WS  +  C   +C+ P  P +  V  I     G  + Y+C  G  L G 
Sbjct: 3253 STTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGG 3312

Query: 1491 SSAECILSGNTAHWSTKPPICQ 1512
            S      +     W+ K P+C+
Sbjct: 3313 SEHRTCKA--DMKWTGKSPVCK 3332



 Score =  320 bits (821), Expect = 8e-87
 Identities = 282/970 (29%), Positives = 408/970 (42%), Gaps = 121/970 (12%)

Query: 124  GSQIKYSCTKGYRLIGSSSATCIISG-DTVIWDNETPICDRIPCGLPPTITNGDFISTNR 182
            GS++ Y C  GYR++G S+ATC  +      WD+ TP+C  + CG+P +  NG F     
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTG--- 2509

Query: 183  ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWS--GPAPQCIIPNKCTP 240
              F   S V Y C+ G      F+L  E S   T+   + G+WS  G  P C  P  C  
Sbjct: 2510 NEFTLDSKVVYECHEG------FKL--ESSQQATAVCQEDGLWSNKGKPPTC-KPVAC-- 2558

Query: 241  PNVENGI-------LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE--PELP 291
            P++E  +       LVS   SL      V   C PG+ ++G R ++CQA   W    E P
Sbjct: 2559 PSIEAQLSEHVIWRLVSG--SLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERP 2616

Query: 292  -----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 346
                 SC  +  PP        T         G    ++C  GY L G+    C   G W
Sbjct: 2617 SCRVISCGSLSFPPNGNKIGTLTVY-------GATAIFTCNTGYTLVGSHVRECLANGLW 2669

Query: 347  SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
            S +   C    C      ++NG +           V + C+ GF+L G+S   C+    +
Sbjct: 2670 SGSETRCLAGHCGS-PDPIVNGHISGD-GFSYRDTVVYQCNPGFRLVGTSVRICL---QD 2724

Query: 407  SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466
              W+   PVC  I C  P    +G   G     F     VN+TC+      T + L G S
Sbjct: 2725 HKWSGQTPVCVPITCGHPGNPAHGFTNGSE---FNLNDVVNFTCN------TGYLLQGVS 2775

Query: 467  TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN-ASDFPIGTSLKYECRP 525
              +C S    NG WSSP P C ++ +C  P     A    Q N    F  G S+ Y C+ 
Sbjct: 2776 RAQCRS----NGQWSSPLPTCRVV-NCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKK 2830

Query: 526  EYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD--IQVGSRINYSCT 582
             +Y    S +TC+ N +W      C   SC  P  P N    V+T      G+ ++YSC 
Sbjct: 2831 GFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANA---VLTGELFTYGAVVHYSCR 2887

Query: 583  TGHRLIGHSSAECILSGNAAHWSTKPPICQRIP---CGLPPTIANGDFISTNRENFHYGS 639
                LIG+ +  C      +HWS   P C       CG P T A+G  +    ++F   S
Sbjct: 2888 GSESLIGNDTRVC---QEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLG---DDFKTKS 2941

Query: 640  VVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILV 699
            ++ + C  G       +L G P   C  N    G WSG  P C   +   P    NG++V
Sbjct: 2942 LLRFSCEMG------HQLRGSPERTCLLN----GSWSGLQPVCEAVSCGNPGTPTNGMIV 2991

Query: 700  SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERT 759
            S +  LFS +  V + C  G+   G     C A   W    P C+ +    P  L A   
Sbjct: 2992 SSDGILFSSS--VIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTL-ANGI 3048

Query: 760  QRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLN 817
            Q   D F+  + V Y C PGY +    +A++RCT  G W+P+ P C+   C      + N
Sbjct: 3049 QFGTD-FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQ-PPPVQN 3106

Query: 818  GRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVI 877
            G V    + + G+ + + C +G+QL  S+   C   G   +W   +P C  +FC  P + 
Sbjct: 3107 GTV-EGSDFRWGSSISYSCMDGYQLSHSAILSCEGRG---VWKGEIPQCLPVFCGDPGIP 3162

Query: 878  PNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
              GR +GK    F +   V + C       + F L+G S   C    Q +G WS   P C
Sbjct: 3163 AEGRLSGKS---FTYKSEVFFQCK------SPFILVGSSRRVC----QADGTWSGIQPTC 3209

Query: 938  GILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSI-TCLDNLVW 992
                H   PD    HF       Q ++  + +G+++ + CR  Y+ +  +  TCL NL W
Sbjct: 3210 IDPAHNTCPDPGTPHF-----GIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTW 3264

Query: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052
            S  +  C   +C+ P  P +  V  I     G  + Y+C  G  L G S      +    
Sbjct: 3265 SGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKAD--M 3322

Query: 1053 HWSTKPPICQ 1062
             W+ K P+C+
Sbjct: 3323 KWTGKSPVCK 3332



 Score =  317 bits (811), Expect = 1e-85
 Identities = 263/902 (29%), Positives = 389/902 (43%), Gaps = 107/902 (11%)

Query: 62   EFPIGTYLNYECRPGY---SGRPFSIICLKNSVWT--GAKDRCRRKSCRNPPDPVNGMVH 116
            EF + + + YEC  G+   S +  + +C ++ +W+  G    C+  +C  P        H
Sbjct: 2511 EFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIEAQLSEH 2568

Query: 117  VIKGI------QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPP 170
            VI  +      ++G+Q+  SC+ GY L G     C  +G   I D E P C  I CG   
Sbjct: 2569 VIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGD-ERPSCRVISCGSLS 2627

Query: 171  TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 230
               NG+ I T      YG+   + CN G      + LVG     C +N    G+WSG   
Sbjct: 2628 FPPNGNKIGTLTV---YGATAIFTCNTG------YTLVGSHVRECLAN----GLWSGSET 2674

Query: 231  QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL 290
            +C+  +  +P  + NG +  D    FS  + V ++C PGF + G     C   +KW  + 
Sbjct: 2675 RCLAGHCGSPDPIVNGHISGDG---FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQT 2731

Query: 291  PSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPA 349
            P C  + C  P +  H      +   F+    V ++C  GY L+G +  +C   G WS  
Sbjct: 2732 PVCVPITCGHPGNPAHGFTNGSE---FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSP 2788

Query: 350  APTCEVKSCDD---FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
             PTC V +C D       + +G+  FP + + G  + + C +GF L GSSA  C+  G  
Sbjct: 2789 LPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG-- 2846

Query: 407  SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466
             LW+ S+P C  I C  P V  N   TG   E+F +G  V+Y+C     RG+   LIG  
Sbjct: 2847 -LWDRSLPKCLAISCGHPGVPANAVLTG---ELFTYGAVVHYSC-----RGSE-SLIGND 2896

Query: 467  TIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
            T  C  D      WS   P C     G  G    P H             DF   + L++
Sbjct: 2897 TRVCQEDSH----WSGALPHCTGNNPGFCGDPGTPAH-------GSRLGDDFKTKSLLRF 2945

Query: 522  ECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579
             C   +   G P   TCL N  WS  + VC+  SC  P  P NGM+     I   S + Y
Sbjct: 2946 SCEMGHQLRGSP-ERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIY 3004

Query: 580  SCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 639
            +C  G++  G  +  C  +G    W+   P C  I CG P T+ANG    T   +F +  
Sbjct: 3005 ACWEGYKTSGLMTRHCTANGT---WTGTAPDCTIISCGDPGTLANGIQFGT---DFTFNK 3058

Query: 640  VVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILV 699
             V+Y+CNPG     V E V   +I CT +    G W+   P C       PP V+NG + 
Sbjct: 3059 TVSYQCNPG----YVMEAVTSATIRCTKD----GRWNPSKPVCKAVLCPQPPPVQNGTVE 3110

Query: 700  SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERT 759
              +   F     + + C  G+ +     + C+    W+ E+P C  V    P +  AE  
Sbjct: 3111 GSD---FRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGI-PAEGR 3166

Query: 760  QRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC---EVKSCDDFMGQLL 816
               K +F+   EVF+ C+  + L G++   C   G WS   PTC      +C D  G   
Sbjct: 3167 LSGK-SFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD-PGTPH 3224

Query: 817  NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPV 876
             G        ++G+ V F C +G+ ++GS+   C LA +   W+     C    C  P  
Sbjct: 3225 FGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTC-LANL--TWSGIQTECIPHACRQPET 3281

Query: 877  IPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAP 935
              +     + +++  FG T+ YTC P       F L G S  R C +D +    W+  +P
Sbjct: 3282 PAHA--DVRAIDLPTFGYTLVYTCHP------GFFLAGGSEHRTCKADMK----WTGKSP 3329

Query: 936  RC 937
             C
Sbjct: 3330 VC 3331



 Score =  312 bits (799), Expect = 3e-84
 Identities = 308/1190 (25%), Positives = 466/1190 (39%), Gaps = 154/1190 (12%)

Query: 42   QCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNS---VWTGAKDR 98
            +C  P  +P A    LT++ +F IG ++ Y+C PGY+     I+  K S    + G+   
Sbjct: 2258 KCQPPPAVPQAEM--LTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315

Query: 99   CRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
            C  +   N     +  V +  G         +C+   ++  + + T  +  DT   + + 
Sbjct: 2316 CEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFV--DTFQSEKQF 2373

Query: 159  PICDRI--PCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCT 216
               +      G  P +       T + NF      T R N                +Y  
Sbjct: 2374 DALEVFDGSSGQSPLLVVLSGNHTEQSNF------TSRSN---------------QLYLR 2412

Query: 217  SNDDQVGIWSG-----PAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 271
             + D      G      AP C +    T P    GIL   NR+  ++   V + C+PG+ 
Sbjct: 2413 WSTDHATSKKGFKIRYAAPYCSL----THPLKNGGIL---NRTAGAVGSKVHYFCKPGYR 2465

Query: 272  MKGPRRVKCQ----ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSC 326
            M G     C+     + +W+   P C  V C  P    +   T  +   F+   +V Y C
Sbjct: 2466 MVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYEC 2522

Query: 327  EPGYDLRGA--ASMRCTPQGDWSPAA--PTCEVKSCDDFMGQLLNGRVLFPVNLQL---G 379
              G+ L  +  A+  C   G WS     PTC+  +C     QL    +   V+  L   G
Sbjct: 2523 HEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYG 2582

Query: 380  AKVDFVCDEGFQLKGSSASYCVLAGMESLWN--SSVPVCEQIFCPSPPVIPNGRHTGKPL 437
            A+V   C  G+ L+G     C   G    WN     P C  I C S    PNG   G   
Sbjct: 2583 AQVLLSCSPGYYLEGWRLLRCQANG---TWNIGDERPSCRVISCGSLSFPPNGNKIG--- 2636

Query: 438  EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPD 497
             +  +G T  +TC+      T + L+G     C +    NG+WS    RC + GHC +PD
Sbjct: 2637 TLTVYGATAIFTCN------TGYTLVGSHVRECLA----NGLWSGSETRC-LAGHCGSPD 2685

Query: 498  HFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSI-TCLDNLVWSSPKDVCKRKSCKT 556
              +   +    +   F    ++ Y+C P +     S+  CL +  WS    VC   +C  
Sbjct: 2686 PIVNGHI----SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGH 2741

Query: 557  PPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPC 616
            P +P +G  +  ++  +   +N++C TG+ L G S A+C  +G    WS+  P C+ + C
Sbjct: 2742 PGNPAHGFTNG-SEFNLNDVVNFTCNTGYLLQGVSRAQCRSNG---QWSSPLPTCRVVNC 2797

Query: 617  GLPPTIANGDFISTNR--ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGI 674
              P  + N          E+F YG  + Y C  G      F L+G  ++ C +N    G+
Sbjct: 2798 SDPGFVENAIRHGQQNFPESFEYGMSILYHCKKG------FYLLGSSALTCMAN----GL 2847

Query: 675  WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN 734
            W    P+C+  +   P    N +L  +   LF+   VV + C+    + G     CQ  +
Sbjct: 2848 WDRSLPKCLAISCGHPGVPANAVLTGE---LFTYGAVVHYSCRGSESLIGNDTRVCQEDS 2904

Query: 735  KWEPELPSCS----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 790
             W   LP C+      C  P    H  R     D+F     + +SCE G+ LRG+    C
Sbjct: 2905 HWSGALPHCTGNNPGFCGDPGTPAHGSRL---GDDFKTKSLLRFSCEMGHQLRGSPERTC 2961

Query: 791  TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 850
               G WS   P CE  SC +  G   NG ++    +   + V + C EG++  G    +C
Sbjct: 2962 LLNGSWSGLQPVCEAVSCGN-PGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHC 3020

Query: 851  VLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 910
               G    W  + P C  I C  P  + NG   G     F F KTV+Y C+P    G   
Sbjct: 3021 TANG---TWTGTAPDCTIISCGDPGTLANGIQFGTD---FTFNKTVSYQCNP----GYVM 3070

Query: 911  DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
            + +  +TIRCT D    G W+   P C  +   Q P              SDF  G+S+ 
Sbjct: 3071 EAVTSATIRCTKD----GRWNPSKPVCKAVLCPQPP-----PVQNGTVEGSDFRWGSSIS 3121

Query: 971  YECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 1029
            Y C   Y       ++C    VW      C    C  P  P  G +         S + +
Sbjct: 3122 YSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSG-KSFTYKSEVFF 3180

Query: 1030 SCTTGHRLIGHSSAECILSGNAAHWSTKPPIC---QRIPCGLPPTIANGDFISTNRENFH 1086
             C +   L+G S   C   G    WS   P C       C  P T   G  I  +   + 
Sbjct: 3181 QCKSPFILVGSSRRVCQADGT---WSGIQPTCIDPAHNTCPDPGTPHFG--IQNSSRGYE 3235

Query: 1087 YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG 1146
             GS V +RC      RK + + G  +  C +N      WSG   +C IP+ C  P     
Sbjct: 3236 VGSTVFFRC------RKGYHIQGSTTRTCLAN----LTWSGIQTEC-IPHACRQPETP-- 3282

Query: 1147 ILVSDNRS--LFSLNEVVEFRCQPGFVMKGPRRVK-CQALNKWEPELPSC 1193
               +D R+  L +    + + C PGF + G    + C+A  KW  + P C
Sbjct: 3283 -AHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331



 Score =  283 bits (724), Expect = 1e-75
 Identities = 307/1181 (25%), Positives = 458/1181 (38%), Gaps = 195/1181 (16%)

Query: 166  CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
            C  PP +   + + T  ++F  G  V Y+C+PG      + LVG   + C  +      +
Sbjct: 2259 CQPPPAVPQAEML-TEDDDFEIGDFVKYQCHPG------YTLVGTDILTCKLSSQLQ--F 2309

Query: 226  SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVV---EFRCQPG-----FVMKG 274
             G  P C    +C    V    +G+++S        N        + +P      FV   
Sbjct: 2310 EGSLPTC--EAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF 2367

Query: 275  PRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 334
                +  AL  ++      S    P   VL    T++   NF+      Y       LR 
Sbjct: 2368 QSEKQFDALEVFDG-----SSGQSPLLVVLSGNHTEQS--NFTSRSNQLY-------LRW 2413

Query: 335  AASMRCTPQG-DWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLK 393
            +     + +G     AAP C +         L NG +L      +G+KV + C  G+++ 
Sbjct: 2414 STDHATSKKGFKIRYAAPYCSLTH------PLKNGGILNRTAGAVGSKVHYFCKPGYRMV 2467

Query: 394  GSSASYCVL--AGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 451
            G S + C     GM   W+S  P+C+ + C  P    NG  TG     F     V Y C 
Sbjct: 2468 GHSNATCRRNPLGMYQ-WDSLTPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECH 2523

Query: 452  PHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPA--PRCGILG----HCQAPDHFLFAKLK 505
                    F L  ES+ + T+  Q +G+WS+    P C  +       Q  +H ++  + 
Sbjct: 2524 ------EGFKL--ESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVS 2575

Query: 506  TQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWS--SPKDVCKRKSCKTPPDPVN 562
               N      G  +   C P YY   +  + C  N  W+    +  C+  SC +   P N
Sbjct: 2576 GSLN----EYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPN 2631

Query: 563  GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTI 622
            G   + T    G+   ++C TG+ L+G    EC+ +G    WS     C    CG P  I
Sbjct: 2632 GN-KIGTLTVYGATAIFTCNTGYTLVGSHVRECLANG---LWSGSETRCLAGHCGSPDPI 2687

Query: 623  ANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 682
             NG     + + F Y   V Y+CNPG      F LVG     C  +      WSG  P C
Sbjct: 2688 VNGHI---SGDGFSYRDTVVYQCNPG------FRLVGTSVRICLQDHK----WSGQTPVC 2734

Query: 683  IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 742
            +      P N  +G     N S F+LN+VV F C  G++++G  R +C++  +W   LP+
Sbjct: 2735 VPITCGHPGNPAHGF---TNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT 2791

Query: 743  CSRV-CQPPPDVLHAER--TQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPA 799
            C  V C  P  V +A R   Q   ++F  G  + Y C+ G+ L G++++ C   G W  +
Sbjct: 2792 CRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRS 2851

Query: 800  APTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLW 859
             P C   SC    G   N  VL       GA V + C     L G+    C     +S W
Sbjct: 2852 LPKCLAISC-GHPGVPANA-VLTGELFTYGAVVHYSCRGSESLIGNDTRVC---QEDSHW 2906

Query: 860  NSSVPVC---EQIFCPSPPVIPNGRHTG---KPLEVFPFGKTVNYTCDPHPDR------- 906
            + ++P C      FC  P    +G   G   K   +  F   + +     P+R       
Sbjct: 2907 SGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGS 2966

Query: 907  ----------------GT------------------------SFDLIGESTIRCTSDPQG 926
                            GT                         +   G  T  CT+    
Sbjct: 2967 WSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTA---- 3022

Query: 927  NGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN----ASDFPIGTSLKYECRPEYYGRPF 982
            NG W+  AP C I+  C  P         T  N     +DF    ++ Y+C P Y     
Sbjct: 3023 NGTWTGTAPDCTIIS-CGDPG--------TLANGIQFGTDFTFNKTVSYQCNPGYVMEAV 3073

Query: 983  ---SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIG 1039
               +I C  +  W+  K VCK   C  PP   NG V   +D + GS I+YSC  G++L  
Sbjct: 3074 TSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEG-SDFRWGSSISYSCMDGYQLSH 3132

Query: 1040 HSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGS 1099
             +   C   G    W  + P C  + CG P   A G     + ++F Y S V ++C    
Sbjct: 3133 SAILSCEGRG---VWKGEIPQCLPVFCGDPGIPAEG---RLSGKSFTYKSEVFFQC---- 3182

Query: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP--NKCTPPNVENGILVSDNRSLFS 1157
              +  F LVG     C ++    G WSG  P CI P  N C  P   +  + + +R  + 
Sbjct: 3183 --KSPFILVGSSRRVCQAD----GTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRG-YE 3235

Query: 1158 LNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNF 1216
            +   V FRC+ G+ ++G     C A   W      C    C+ P    HA+    D   F
Sbjct: 3236 VGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF 3295

Query: 1217 SPGQEVFYSCEPGYDLRGAASMR-CTPQGDWSPAAPTCEVK 1256
              G  + Y+C PG+ L G +  R C     W+  +P C+ K
Sbjct: 3296 --GYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSK 3334



 Score =  275 bits (702), Expect = 5e-73
 Identities = 262/970 (27%), Positives = 360/970 (37%), Gaps = 135/970 (13%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C L   + NG  +  NR     GS V Y C  G R      +VG  +  C  N   +  W
Sbjct: 2433 CSLTHPLKNGGIL--NRTAGAVGSKVHYFCKPGYR------MVGHSNATCRRNPLGMYQW 2484

Query: 1576 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK--CQAL 1633
                P C   +   P +  NG    +    F+L+  V + C  GF ++  ++    CQ  
Sbjct: 2485 DSLTPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECHEGFKLESSQQATAVCQED 2541

Query: 1634 NKW--EPELPSCSRVCQPPPEILHGEHTPSHQDNFSP---GQEVFYSCEPGYDLRGAASL 1688
              W  + + P+C  V  P  E    EH      + S    G +V  SC PGY L G   L
Sbjct: 2542 GLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLL 2601

Query: 1689 HCTPQGDWS--PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSS 1746
             C   G W+   E P C V SC   L   P+G  +  L +  GA   F C+ G+ L GS 
Sbjct: 2602 RCQANGTWNIGDERPSCRVISCGS-LSFPPNGNKIGTLTVY-GATAIFTCNTGYTLVGSH 2659

Query: 1747 VSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDR 1806
            V  C+  G   LW+ S   C    C +P  I+NG  +G       Y   + Y C+P    
Sbjct: 2660 VRECLANG---LWSGSETRCLAGHCGSPDPIVNGHISGD---GFSYRDTVVYQCNPG--- 2710

Query: 1807 GMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEF 1866
               F L+G S   C  D      WS   P C + +  GH   P    F       N  EF
Sbjct: 2711 ---FRLVGTSVRICLQDHK----WSGQTPVC-VPITCGHPGNPAH-GFT------NGSEF 2755

Query: 1867 PVGTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVH----IN 1921
             +   +N+ C  GY  +  S   C  N  WSS    CR  +C  P    N + H      
Sbjct: 2756 NLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFP 2815

Query: 1922 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFY 1981
               ++G ++ Y C +GF L+GS + TC+ +G    WD+  P C  ISC  P   +N    
Sbjct: 2816 ESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCLAISCGHPGVPANAVLT 2872

Query: 1982 SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKC 2041
                  F  G VV Y C           L+G  +  C         WS   P C   N  
Sbjct: 2873 GE---LFTYGAVVHYSCRGSES------LIGNDTRVCQEDSH----WSGALPHCTGNNPG 2919

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-C 2100
               +             F    ++RF C+ G  + GS    C  NG W    P C  V C
Sbjct: 2920 FCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSC 2979

Query: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS 2160
              P    +G    S    FS    V Y+C   Y   G  + HCT  G W+  AP CT+ S
Sbjct: 2980 GNPGTPTNGMIVSSDGILFS--SSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIIS 3037

Query: 2161 CDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSAS--HCVLAGMKALWNSSVPV 2218
            C D  G L +G +    +      VS+ C+ G+ ++  +++   C   G    WN S PV
Sbjct: 3038 CGD-PGTLANG-IQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGR---WNPSKPV 3092

Query: 2219 CEQIFCPNPPAILNGRHTGTPF-------------------------------GDIPY-- 2245
            C+ + CP PP + NG   G+ F                               G+IP   
Sbjct: 3093 CKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL 3152

Query: 2246 ----------------GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPR 2289
                            GK  +Y  +        F L+G S   C +D    G WS   P 
Sbjct: 3153 PVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQAD----GTWSGIQPT 3208

Query: 2290 CELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQ 2349
            C       CP P     G  I      Y  G T+ + C  GY + G     C     WS 
Sbjct: 3209 CIDPAHNTCPDPGTPHFG--IQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSG 3266

Query: 2350 LDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLE-GSPWSQCQADDRW 2408
            +   C    C  P        ++    +  +G  +   C  G+ L  GS    C+AD +W
Sbjct: 3267 IQTECIPHACRQP--ETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKW 3324

Query: 2409 DPPLAKCTSR 2418
                  C S+
Sbjct: 3325 TGKSPVCKSK 3334



 Score =  100 bits (249), Expect = 2e-20
 Identities = 294/1449 (20%), Positives = 463/1449 (31%), Gaps = 389/1449 (26%)

Query: 997  DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS-GNAAHWS 1055
            +V    +C  P + + G++H  T   +G +I YSC  G+ L GH+   CI+S GN A W 
Sbjct: 138  EVLPSHTCGNPGEILKGVLHG-TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWD 196

Query: 1056 TKPPICQRIPC------GLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109
               P C+          G   +I++  F S    N       T    PG     VF    
Sbjct: 197  FPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNAD--CTWTILAEPGDTIALVFT--- 251

Query: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169
                      D + I    AP   +    T  N+ + ++ S N            R + G
Sbjct: 252  --DFQLEEGYDFLEISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHR-RKG 304

Query: 1170 FVMKGPRRVKCQALNKWEPELPS--------------CSRVCQPPPDVLHAERTQRDKDN 1215
            F  +   +   +  ++    LPS               + V    PD    E  +R   +
Sbjct: 305  FNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSD 364

Query: 1216 FSP-GQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNG-- 1268
            FS  G  V +SCE  Y L+G+ S+ C    +    WS   P C  ++C    G  L G  
Sbjct: 365  FSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC----GSNLRGPS 420

Query: 1269 ----RVLFPVNLQLGAKV------------------DFVCDEGFQ--------------- 1291
                   +PV  +  A                    +F  + G+                
Sbjct: 421  GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRS 480

Query: 1292 ----LKGSSASYCVLAGMESLW-------NSSVPVCEQIF-------CPSPPVIPNGRHT 1333
                L GSS    +++    +W       +   P  + ++       C  P +   G+ T
Sbjct: 481  VLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRT 540

Query: 1334 GKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG--------------- 1378
            G     F  G  + + C        +F+L+GE  I C  + Q +G               
Sbjct: 541  GSS---FLHGDTLTFECP------AAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTA 591

Query: 1379 --------------------VW---SSPAPRCGIL-GHCQAPDHFLFAKLKTQTNASDFP 1414
                                VW   S P  R  ++         F F  +K    +    
Sbjct: 592  SSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITV 651

Query: 1415 IGT-----------------SLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTP 1457
            +GT                  L+++      GR F+IT               +  C  P
Sbjct: 652  LGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYT----------TFGQNECHDP 701

Query: 1458 PDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNTAHWSTKPPICQRIPC 1516
              P+NG         +GS +++ C  G  +  G  S  CIL      WS+  P C+  PC
Sbjct: 702  GIPINGR-RFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA-PC 759

Query: 1517 GLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV---FELVGEPSIYCT------- 1566
            G   T ++G  +      ++  S+          G  +   F+       Y T       
Sbjct: 760  GGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGP 819

Query: 1567 -SNDDQVGIWSGP-APQCIIP-------------------------------NKCTPPNV 1593
             S+   +G + G  APQ +I                                + C  P  
Sbjct: 820  ASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDP-- 877

Query: 1594 ENGILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 1651
              GI V+ +R    F +   V F C PG+ +     + C+  ++W   LPSC        
Sbjct: 878  --GIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC-------- 927

Query: 1652 EILHGEHTPSHQDN-FSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD 1710
            + L G +         SPG   FY            SL+CT    W+ E           
Sbjct: 928  DALCGGYIQGKSGTVLSPGFPDFYP----------NSLNCT----WTIE----------- 962

Query: 1711 FLGQLPHGR----VLFPLNLQLGAKVSFVCDEGF------RLKGSSVSHCVLVGMR---- 1756
                + HG+    +    +L+       + ++G       RL GS + H +  G+     
Sbjct: 963  ----VSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFT 1018

Query: 1757 -----------SLWNNSVPVCEHIF--CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPH 1803
                       S    ++   E+    C +P      R  G   G    G  ++++C   
Sbjct: 1019 AQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFG---VGDSLTFSCF-- 1073

Query: 1804 PDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN- 1862
                + + L G + + C     G  VWS+P PRC      G      +    SP  P N 
Sbjct: 1074 ----LGYRLEGATKLTCLGG--GRRVWSAPLPRCV--AECGASVKGNEGTLLSPNFPSNY 1125

Query: 1863 --------DFEFPVGTSLNYECRPG----------YFGKMFS----------------IS 1888
                      E   G  ++   R            Y GK  S                ++
Sbjct: 1126 DNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILN 1185

Query: 1889 CLENLVWSSVEDNCRRKS--------------CGPPPEPFNGMVHINTDTQFGSTVN-YS 1933
               N +W     N                   C  P  P  G   I  +  F  TV  YS
Sbjct: 1186 STSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGY-RIRDEGHFTDTVVLYS 1244

Query: 1934 CNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC--EPPPTISNGDFYSNNRTSFHNG 1991
            CN G+ + GS + TCL SG+   WDK  P C I  C  +     S           + N 
Sbjct: 1245 CNPGYAMHGSNTLTCL-SGDRRVWDKPLPSC-IAECGGQIHAATSGRILSPGYPAPYDNN 1302

Query: 1992 TVVTYQCHTGPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTNKCTAPEVENAI 2050
               T+     P        +    ++ T    D + VW  P    I   + +   +   I
Sbjct: 1303 LHCTWIIEADPGKTISLHFI----VFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDI 1358

Query: 2051 RVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGE 2110
                + +F +LT  ++F     F+     ++Q  T+          +  C  P    +G 
Sbjct: 1359 ----HSTFNSLT--LQFD-SDFFISKSGFSIQFSTS---------IAATCNDPGMPQNGT 1402

Query: 2111 HTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD---WSPEAPRCTVKSCDDFLGQ 2167
                + D+   G  V + C+P Y L+G A + C    +   W P+ P C      +  G 
Sbjct: 1403 R---YGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTG- 1458

Query: 2168 LPHGRVLLP 2176
             P G +L P
Sbjct: 1459 -PAGVILSP 1466



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 328/1583 (20%), Positives = 508/1583 (32%), Gaps = 386/1583 (24%)

Query: 88   KNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII 147
            KNSV +          C +P  P NG        + G+ +++SC   Y L GS S TC  
Sbjct: 333  KNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQR 392

Query: 148  SGDTVI-WDNETPICDRIPCGLPPTITNGDFISTN-----RENFHYGSVVTYRCNPGSGG 201
              +T+  W +  PIC    CG      +G   S N      +N H   V+T   +P    
Sbjct: 393  VTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVIT-TTDPDKVI 451

Query: 202  RKVFE-----------LVGEPS--------------------IYCTSN--------DDQV 222
            +  FE            VG+                      I   SN        DD +
Sbjct: 452  KLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSI 511

Query: 223  GIWSGPAP-QCIIPNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVK 279
            G     A  Q I    C  P    GI     R  S F   + + F C   F + G R + 
Sbjct: 512  GSPGFKAVYQEIEKGGCGDP----GIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVIT 567

Query: 280  CQALNKWEPELP----SCSRVCQPPPDVLHAERTQRDKDN---------FSPGQEVF--- 323
            CQ  N+W    P    SC         ++ +     +  N           PG  +    
Sbjct: 568  CQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIF 627

Query: 324  --YSCEPGYDLRGAAS---------------------------MRCTPQGDWSPAA---- 350
              +  EP +D                                 +R   Q D S       
Sbjct: 628  NDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFN 687

Query: 351  ---PTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGME 406
                T     C D  G  +NGR  F     LG+ V F CD+GF + +GS +  C+L    
Sbjct: 688  ITYTTFGQNECHD-PGIPINGR-RFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGN 745

Query: 407  SLWNSSVPVCE-----QIFCPSPPVIPNG--------RHTGKPLEVFPFGKTVNYTCDPH 453
             +W+S+VP CE      +   S  ++P G         H    +E  P G ++  T D  
Sbjct: 746  VVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKP-GHSIKITFDRF 804

Query: 454  PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFL----FAKLKTQTN 509
                     +   T+     P      +S +P  G     QAP   +    F  L   T+
Sbjct: 805  QTE------VNYDTLEVRDGP------ASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTD 852

Query: 510  ASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT 569
             S   IG  + YE          S+T              +  SC  P  PVNG  H   
Sbjct: 853  NSRSSIGFLIHYE----------SVT-------------LESDSCLDPGIPVNGHRHG-G 888

Query: 570  DIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIS 629
            D  + S + +SC  G+ L   S  E ++      W+   P C  + CG      +G  +S
Sbjct: 889  DFGIRSTVTFSCDPGYTL---SDDEPLVCERNHQWNHALPSCDAL-CGGYIQGKSGTVLS 944

Query: 630  TNRENFHYGSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN 686
                +F+  S+    T   + G G + +F      S +      + G +S P  +  +  
Sbjct: 945  PGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVAR--LTG 1002

Query: 687  KCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
               P  ++ G+  +             F  Q  F+       +   +   E +L  C   
Sbjct: 1003 SVLPHTIKAGLFGN-------------FTAQLRFISDFSISYEGFNITFSEYDLEPCDDP 1049

Query: 747  CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD--WSPAAPTCE 804
              P         ++R   +F  G  + +SC  GY L GA  + C   G   WS   P C 
Sbjct: 1050 GVP-------AFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102

Query: 805  VK---SCDDFMGQLL----------NGRVLFPVNLQLGAKV-----DFVCDEGFQLK--- 843
             +   S     G LL          N   ++ +  + G  +      F   EG  LK   
Sbjct: 1103 AECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYD 1162

Query: 844  GSSASYCVL--------------AGMESLW---NSSVPVCEQIF-----------CPSPP 875
            G  +S   L              +    LW   N++    +Q F           C  P 
Sbjct: 1163 GKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPG 1222

Query: 876  VIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAP 935
             IPN  +  +    F     V Y+C+P       + + G +T+ C S  +   VW  P P
Sbjct: 1223 -IPNYGYRIRDEGHFT-DTVVLYSCNP------GYAMHGSNTLTCLSGDR--RVWDKPLP 1272

Query: 936  RCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL----- 990
             C  +  C    H   A    +  +  +P        C       P     L  +     
Sbjct: 1273 SC--IAECGGQIH---AATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTE 1327

Query: 991  -------VWSSPKD---VCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1040
                   VW  P D   + K  S    P+ ++   + +T +Q  S    S          
Sbjct: 1328 MAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLT-LQFDSDFFIS---------- 1376

Query: 1041 SSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSG 1100
                   SG +  +ST         C  P    NG     +RE    G  VT++C+PG  
Sbjct: 1377 ------KSGFSIQFSTS----IAATCNDPGMPQNGTRYGDSRE---AGDTVTFQCDPG-- 1421

Query: 1101 GRKVFELVGEPSIYCTSNDDQV--------------GIWSGPAPQCIIPN--KCTPPNVE 1144
                ++L G+  I C   +++               G  +GPA   + PN  +  PP  E
Sbjct: 1422 ----YQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKE 1477

Query: 1145 NGILVSDNRSLFSLNEVVEFRCQPGFVM--------------------KGPRRVKCQ--- 1181
                V  N           F  +P +                      + P R++     
Sbjct: 1478 CDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNS 1537

Query: 1182 -----------ALNKWEPELPSCSR-VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG 1229
                        L+ +  E     R  C  P ++++  R   D   F  G  + Y C+ G
Sbjct: 1538 LFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRVGTD---FKLGSTITYQCDSG 1594

Query: 1230 YDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV 1285
            Y +   +S+ C    D    W    P+C       + G    G VL P N         +
Sbjct: 1595 YKILDPSSITCVIGADGKPSWDQVLPSCNAPCGGQYTGS--EGVVLSP-NYPHNYTAGQI 1651

Query: 1286 CDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIP-NGRHTGKPLEVFPFGK 1344
            C     +      +   A  ++  N    + +     +  +   +G H+G+ L +    +
Sbjct: 1652 CLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQ 1711

Query: 1345 AVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKL 1404
             +             F  + ++  R TSD Q + V   P PR G                
Sbjct: 1712 ILLRFSAKSGASARGFHFVYQAVPR-TSDTQCSSV---PEPRYG---------------- 1751

Query: 1405 KTQTNASDFPIGTSLKYECRPEY 1427
              +   S+F  G+ +++EC P Y
Sbjct: 1752 --RRIGSEFSAGSIVRFECNPGY 1772



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 148/674 (21%), Positives = 242/674 (35%), Gaps = 172/674 (25%)

Query: 182  RENFHY-GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI------- 233
            R+  H+  +VV Y CNPG      + + G  ++ C S D +V  W  P P CI       
Sbjct: 1231 RDEGHFTDTVVLYSCNPG------YAMHGSNTLTCLSGDRRV--WDKPLPSCIAECGGQI 1282

Query: 234  -------IPNKCTPPNVENG-----ILVSDNRSLFSLNEVVEFRCQPGFVMK---GPRRV 278
                   I +   P   +N      I+ +D     SL+ +V        ++K   GP   
Sbjct: 1283 HAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDS 1342

Query: 279  KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338
                L +W     S S + +      ++   Q D D        F+  + G+ ++ + S+
Sbjct: 1343 DI-LLKEW-----SGSALPEDIHSTFNSLTLQFDSD--------FFISKSGFSIQFSTSI 1388

Query: 339  RCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSAS 398
              T                C+D  G   NG   +  + + G  V F CD G+QL+G +  
Sbjct: 1389 AAT----------------CND-PGMPQNG-TRYGDSREAGDTVTFQCDPGYQLQGQAKI 1430

Query: 399  YCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL-EVFPFGKTVNYTCDPHPD-- 455
             CV       W    P C    C      P G        + +P GK  ++    +PD  
Sbjct: 1431 TCVQLNNRFFWQPDPPTCIAA-CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFV 1489

Query: 456  ---------RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 506
                        S+D +       ++ P       S AP        ++  + LF  L  
Sbjct: 1490 IALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPE-----RIESSGNSLF--LAF 1542

Query: 507  QTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVH 566
            +++AS    G +++++ +P                         R++C  P + +NG   
Sbjct: 1543 RSDASVGLSGFAIEFKEKP-------------------------REACFDPGNIMNG-TR 1576

Query: 567  VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQRIPCGLPPTIANG 625
            V TD ++GS I Y C +G++++  SS  C++  +    W    P C   PCG   T + G
Sbjct: 1577 VGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC-NAPCGGQYTGSEG 1635

Query: 626  DFISTN-RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 684
              +S N   N+  G +  Y         K F + G+ + + T+ +D   ++ G   Q  +
Sbjct: 1636 VVLSPNYPHNYTAGQICLYSITV----PKEFVVFGQFAYFQTALNDLAELFDGTHAQARL 1691

Query: 685  --------PNKCTPPNVENGILV-----------------------SDNR---------- 703
                      +  P    N IL+                       SD +          
Sbjct: 1692 LSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYG 1751

Query: 704  ----SLFSLNEVVEFRCQPGFVMKGPRRVKCQ----ALNKWEPELPSCSRVCQPPPDVLH 755
                S FS   +V F C PG++++G   + CQ    AL +W   +PSC   C        
Sbjct: 1752 RRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCS------- 1804

Query: 756  AERTQRDKDNFSPG 769
               TQR     SPG
Sbjct: 1805 GNFTQRRGTILSPG 1818



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 70/270 (25%), Positives = 105/270 (38%), Gaps = 64/270 (23%)

Query: 101  RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159
            R++C +P + +NG   V    + GS I Y C  GY+++  SS TC+I  D    WD   P
Sbjct: 1562 REACFDPGNIMNG-TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620

Query: 160  ICDRIPCGLPPTITNGDFISTN-RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
             C+  PCG   T + G  +S N   N+  G +  Y         K F + G+ + + T+ 
Sbjct: 1621 SCN-APCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITV----PKEFVVFGQFAYFQTAL 1675

Query: 219  DDQVGIWSGPAPQCII--------PNKCTPPNVENGILV--------------------- 249
            +D   ++ G   Q  +          +  P    N IL+                     
Sbjct: 1676 NDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVP 1735

Query: 250  --SDNR--------------SLFSLNEVVEFRCQPGFVMKGPRRVKCQ----ALNKWEPE 289
              SD +              S FS   +V F C PG++++G   + CQ    AL +W   
Sbjct: 1736 RTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDT 1795

Query: 290  LPSCSRVCQPPPDVLHAERTQRDKDNFSPG 319
            +PSC   C           TQR     SPG
Sbjct: 1796 IPSCVVPCS-------GNFTQRRGTILSPG 1818



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 143/677 (21%), Positives = 234/677 (34%), Gaps = 152/677 (22%)

Query: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC- 1511
            +C  P  P NG  +  +  + G  + + C  G++L G +   C+   N   W   PP C 
Sbjct: 1391 TCNDPGMPQNGTRYGDSR-EAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCI 1449

Query: 1512 ----------------QRIPCGLPP-------TIANGDFI------STNRE------NFH 1536
                               P   PP          N DF+      S N E      + +
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIY 1509

Query: 1537 YGS------VVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSG--------PAPQC 1582
             G       + +Y+   GS+  +  E  G        +D  VG+ SG        P   C
Sbjct: 1510 EGEDSNSPLIGSYQ---GSQAPERIESSGNSLFLAFRSDASVGL-SGFAIEFKEKPREAC 1565

Query: 1583 IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC----QALNKWEP 1638
                   P N+ NG  V  +   F L   + ++C  G+ +  P  + C         W+ 
Sbjct: 1566 F-----DPGNIMNGTRVGTD---FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQ 1617

Query: 1639 ELPSCSRVCQPPPEILHGEHT--------PSHQDNFSPGQEVFYS--CEPGYDLRGAASL 1688
             LPSC+  C        G++T        P++  N++ GQ   YS      + + G  + 
Sbjct: 1618 VLPSCNAPC-------GGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAY 1670

Query: 1689 HCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLN-LQLGAKVSFVCDEGFRLKGSSV 1747
              T   D +           + F G     R+L  L+    G  +         L+ S+ 
Sbjct: 1671 FQTALNDLA-----------ELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAK 1719

Query: 1748 SHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRG 1807
            S     G   ++  +VP      C + P    GR  G+   +   G  + + C+P     
Sbjct: 1720 SGASARGFHFVY-QAVPRTSDTQCSSVPEPRYGRRIGS---EFSAGSIVRFECNP----- 1770

Query: 1808 MTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFP 1867
              + L G + + C S P+    W+   P C +        T  +    SP  P      P
Sbjct: 1771 -GYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNF--TQRRGTILSPGYP-----EP 1822

Query: 1868 VGTSLNYECR------PGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHIN 1921
             G +LN   +       G   ++ S +  +N  W S+E +       P    F+G     
Sbjct: 1823 YGNNLNCIWKIIVTEGSGIQIQVISFATEQN--WDSLEIHDGGDVTAPRLGSFSG----- 1875

Query: 1922 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISN---- 1977
              T   + +N + N+ + L      +   +G ++ +        + +C+ P   SN    
Sbjct: 1876 --TTVPALLNSTSNQLY-LHFQSDISVAAAGFHLEYKTVG----LAACQEPALPSNSIKI 1928

Query: 1978 GDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 2037
            GD Y  N        V+++QC  G      + L G   I C      V  W+ P P CI+
Sbjct: 1929 GDRYMVN-------DVLSFQCEPG------YTLQGRSHISC--MPGTVRRWNYPSPLCIA 1973

Query: 2038 TNKCTAPEVENAIRVPG 2054
            T   T   +   I  PG
Sbjct: 1974 TCGGTLSTLGGVILSPG 1990



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 109/468 (23%), Positives = 165/468 (35%), Gaps = 107/468 (22%)

Query: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVS-GNNVTWDKKAPIC 1964
            +CG P E   G++H  T    G  + YSC  G+ L G    TC+VS GN  +WD  AP C
Sbjct: 144  TCGNPGEILKGVLH-GTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202

Query: 1965 EIISC------EPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQL------FELVG 2012
                           +IS+  F S     + N    T+     P G+ +      F+L  
Sbjct: 203  RAEGACGGTLRGTSSSISSPHFPS----EYENNADCTWTILAEP-GDTIALVFTDFQLEE 257

Query: 2013 ERSIYCTSKDDQVGVW----SSPPPRCISTNKCTAPEVENA-IRVPGNRSFFTLTEIIRF 2067
                   S  +   +W    + P P   S N        ++  R  G  + F + + I  
Sbjct: 258  GYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIEL 317

Query: 2068 RCQPGFVMV----GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQ 2123
            + + G  M+    GSH     + G  G  L   S +C  P    +G    S  D    G 
Sbjct: 318  KSR-GVKMLPSKDGSHKNSVLSQG--GVAL--VSDMCPDPGIPENGRRAGS--DFSRVGA 370

Query: 2124 EVFYSCEPSYDLRGAASLHCTPQGD----WSPEAPRCTVKSCDDFLGQLPHGRVLLP--- 2176
             V +SCE +Y L+G+ S+ C    +    WS   P C  ++C   L + P G +  P   
Sbjct: 371  NVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNL-RGPSGVITSPNYP 429

Query: 2177 ----------------------------LNLQLGAKVSFVCDEG---------FRLKGRS 2199
                                          L+ G     V D G         + L G S
Sbjct: 430  VQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSS 489

Query: 2200 ASHCVLAGMKALW-------NSSVPVCEQIF-------CPNPPAILNGRHTGTPFGDIPY 2245
                +++    +W       +   P  + ++       C +P     G+ TG+ F    +
Sbjct: 490  VPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSF---LH 546

Query: 2246 GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 2293
            G  +++ C         F L+GE  I C    Q N  WS   P C  S
Sbjct: 547  GDTLTFECPA------AFELVGERVITC----QQNNQWSGNKPSCVFS 584



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 105/474 (22%), Positives = 162/474 (34%), Gaps = 113/474 (23%)

Query: 547 DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS-GNAAHWS 605
           +V    +C  P + + G++H  T   +G +I YSC  G+ L GH+   CI+S GN A W 
Sbjct: 138 EVLPSHTCGNPGEILKGVLHG-TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWD 196

Query: 606 TKPPICQRIPC------GLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 659
              P C+          G   +I++  F S    N       T    PG     VF    
Sbjct: 197 FPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENN--ADCTWTILAEPGDTIALVF---- 250

Query: 660 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 719
                     D + I    AP   +    T  N+ + ++ S N            R + G
Sbjct: 251 -TDFQLEEGYDFLEISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHR-RKG 304

Query: 720 FVMKGPRRVKCQALNKWEPELPS--------------CSRVCQPPPDVLHAERTQRDKDN 765
           F  +   +   +  ++    LPS               + V    PD    E  +R   +
Sbjct: 305 FNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSD 364

Query: 766 FS-PGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNG-- 818
           FS  G  V +SCE  Y L+G+ S+ C    +    WS   P C  ++C    G  L G  
Sbjct: 365 FSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC----GSNLRGPS 420

Query: 819 ----RVLFPVNLQLGAKV------------------DFVCDEGFQ--------------- 841
                  +PV  +  A                    +F  + G+                
Sbjct: 421 GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRS 480

Query: 842 ----LKGSSASYCVLAGMESLW-------NSSVPVCEQIF-------CPSPPVIPNGRHT 883
               L GSS    +++    +W       +   P  + ++       C  P +   G+ T
Sbjct: 481 VLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRT 540

Query: 884 GKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
           G     F  G T+ + C        +F+L+GE  I C    Q N  WS   P C
Sbjct: 541 GSS---FLHGDTLTFECP------AAFELVGERVITC----QQNNQWSGNKPSC 581



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 104/468 (22%), Positives = 160/468 (34%), Gaps = 113/468 (24%)

Query: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIIS-GDTVIWDNETPIC 161
           +C NP + + G++H  +    G +I+YSC  GY L G +  TCI+S G+   WD   P C
Sbjct: 144 TCGNPGEILKGVLHGTR-FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202

Query: 162 DRIPC------GLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYC 215
                      G   +I++  F S    N       T    PG     VF          
Sbjct: 203 RAEGACGGTLRGTSSSISSPHFPSEYENN--ADCTWTILAEPGDTIALVF-----TDFQL 255

Query: 216 TSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275
               D + I    AP   +    T  N+ + ++ S N            R + GF  +  
Sbjct: 256 EEGYDFLEISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHR-RKGFNAQFQ 310

Query: 276 RRVKCQALNKWEPELPS--------------CSRVCQPPPDVLHAERTQRDKDNFS-PGQ 320
            +   +  ++    LPS               + V    PD    E  +R   +FS  G 
Sbjct: 311 VKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGA 370

Query: 321 EVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNG------RV 370
            V +SCE  Y L+G+ S+ C    +    WS   P C  ++C    G  L G        
Sbjct: 371 NVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC----GSNLRGPSGVITSP 426

Query: 371 LFPVNLQLGAKV------------------DFVCDEGFQ-------------------LK 393
            +PV  +  A                    +F  + G+                    L 
Sbjct: 427 NYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLT 486

Query: 394 GSSASYCVLAGMESLW-------NSSVPVCEQIF-------CPSPPVIPNGRHTGKPLEV 439
           GSS    +++    +W       +   P  + ++       C  P +   G+ TG     
Sbjct: 487 GSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSS--- 543

Query: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
           F  G T+ + C        +F+L+GE  I C    Q N  WS   P C
Sbjct: 544 FLHGDTLTFECP------AAFELVGERVITC----QQNNQWSGNKPSC 581



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 130/618 (21%), Positives = 204/618 (33%), Gaps = 84/618 (13%)

Query: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIP 1791
            V + C+ G+ + GS+   C L G R +W+  +P C         A  +GR   +P    P
Sbjct: 1241 VLYSCNPGYAMHGSNTLTC-LSGDRRVWDKPLPSCIAECGGQIHAATSGRIL-SPGYPAP 1298

Query: 1792 YGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGHCKTPE 1850
            Y   +  T     D G T +L     +  T   H    VW  P     L         PE
Sbjct: 1299 YDNNLHCTWIIEADPGKTISL--HFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPE 1356

Query: 1851 QF--PFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCG 1908
                 F S T+   D +F +  S         F   FS S                 +C 
Sbjct: 1357 DIHSTFNSLTLQF-DSDFFISKS--------GFSIQFSTSIAA--------------TCN 1393

Query: 1909 PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIIS 1968
             P  P NG        + G TV + C+ G++L G    TC+   N   W    P C I +
Sbjct: 1394 DPGMPQNG-TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC-IAA 1451

Query: 1969 CEPPPTISNGDFYSNNRTS-FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGV 2027
            C    T   G   S N    +  G    ++    PD   +  L+  +S       D + +
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPD--FVIALI-FKSFNMEPSYDFLHI 1508

Query: 2028 WSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNG 2087
            +                +    I   GN  F      + FR     V +    ++ +   
Sbjct: 1509 YEGEDSNSPLIGSYQGSQAPERIESSGNSLF------LAFRSDAS-VGLSGFAIEFKEKP 1561

Query: 2088 RWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQG 2147
            R           C  P  I++G        +F  G  + Y C+  Y +   +S+ C    
Sbjct: 1562 R---------EACFDPGNIMNGTRV---GTDFKLGSTITYQCDSGYKILDPSSITCVIGA 1609

Query: 2148 D----WSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 2203
            D    W    P C       + G    G VL P N         +C     +        
Sbjct: 1610 DGKPSWDQVLPSCNAPCGGQYTGS--EGVVLSP-NYPHNYTAGQICLYSITV----PKEF 1662

Query: 2204 VLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTF 2263
            V+ G  A + +++    ++F        +G H          G   S++ +T P    + 
Sbjct: 1663 VVFGQFAYFQTALNDLAELF--------DGTHAQARLLSSLSG---SHSGETLP-LATSN 1710

Query: 2264 NLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTI 2323
             ++   S +  +  +G        PR   +    C   P+ + G  IG   S    G  +
Sbjct: 1711 QILLRFSAKSGASARGFHFVYQAVPR---TSDTQCSSVPEPRYGRRIGSEFS---AGSIV 1764

Query: 2324 SYICDPGYLLVGKGFIFC 2341
             + C+PGYLL G   + C
Sbjct: 1765 RFECNPGYLLQGSTALHC 1782



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 106/443 (23%), Positives = 150/443 (33%), Gaps = 93/443 (20%)

Query: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965
            C  P  P NG    +  ++ G+ V +SC + + L GS S TC  V+     W    PIC 
Sbjct: 349  CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408

Query: 1966 IISCE-----PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPD-----GEQLFELVGERS 2015
              +C      P   I++ ++      + H   V+T    T PD       + FEL     
Sbjct: 409  ARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITT---TDPDKVIKLAFEEFELERGYD 465

Query: 2016 IYCTSKDDQVG---------VWSSPPPRCISTN------------------KCTAPEVEN 2048
                    +VG           SS P   +S +                  K    E+E 
Sbjct: 466  TLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEK 525

Query: 2049 A------IRVPGNR--SFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
                   I   G R  S F   + + F C   F +VG   + CQ N +W    P C   C
Sbjct: 526  GGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSC 585

Query: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDW---SPEAPRCT 2157
                             NF+    +  S  P+Y      +++C     W   S    R  
Sbjct: 586  F---------------FNFTASSGIILS--PNYPEEYGNNMNCV----WLIISEPGSRIH 624

Query: 2158 VKSCD-------DFLGQLPHG-RVLLPLNLQLGAKV-SFVCDEGFRLKGRSASHCVLAGM 2208
            +   D       DFL     G   +  L    G +V S +   G  ++    S     G 
Sbjct: 625  LIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGR 684

Query: 2209 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 2268
               +N +     Q  C +P   +NGR  G  F     G  +S+ CD    +       G 
Sbjct: 685  G--FNITYTTFGQNECHDPGIPINGRRFGDRF---LLGSSVSFHCDDGFVKTQ-----GS 734

Query: 2269 SSIRCTSDPQGNGVWSSPAPRCE 2291
             SI C     GN VWSS  PRCE
Sbjct: 735  ESITCILQ-DGNVVWSSTVPRCE 756



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 154/782 (19%), Positives = 251/782 (32%), Gaps = 209/782 (26%)

Query: 1669 GQEVFYSCEPGYDLRGAASLHCTPQGD----WSPEAPRCAVKSCDDFLGQLPHGRVLFP- 1723
            G  V +SCE  Y L+G+ S+ C    +    WS   P C  ++C   L + P G +  P 
Sbjct: 369  GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNL-RGPSGVITSPN 427

Query: 1724 ------------------------------LNLQLGAKVSFVCDEG---------FRLKG 1744
                                            L+ G     V D G         + L G
Sbjct: 428  YPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTG 487

Query: 1745 SSVSHCVLVGMRSLW-----NNSV--PVCEHIF-------CPNPPAILNGRHTGTPSGDI 1790
            SSV   ++     +W     ++S+  P  + ++       C +P     G+ TG+     
Sbjct: 488  SSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGS---SF 544

Query: 1791 PYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHC---- 1846
             +G  +++ C         F L+GE  I C  +   +G   S    C  +  A       
Sbjct: 545  LHGDTLTFECPA------AFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILS 598

Query: 1847 -KTPEQF-------------PFASPTIPINDFEFP------------------VGTSLNY 1874
               PE++             P +   +  NDF+                    +GT    
Sbjct: 599  PNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGN 658

Query: 1875 ECRPGYFGKMFSISCLE------------NLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922
            E  P        I  LE            N+ +++   N     C  P  P NG      
Sbjct: 659  EV-PSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQN----ECHDPGIPINGR-RFGD 712

Query: 1923 DTQFGSTVNYSCNEGF-RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFY 1981
                GS+V++ C++GF +  GS S TC++   NV W    P CE   C    T S+G   
Sbjct: 713  RFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCE-APCGGHLTASSGVIL 771

Query: 1982 SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKC 2041
                  ++  ++          G  + ++  +R        D + V   P        + 
Sbjct: 772  PPGWPGYYKDSLHCEWIIEAKPGHSI-KITFDR-FQTEVNYDTLEVRDGPASSSPLIGEY 829

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQ 2101
               +    +   GN  +   T     R   GF ++   +V  +++    P +P       
Sbjct: 830  HGTQAPQFLISTGNFMYLLFT-TDNSRSSIGF-LIHYESVTLESDSCLDPGIP------- 880

Query: 2102 PPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSC 2161
                 ++G     H  +F     V +SC+P Y L     L C     W+   P C    C
Sbjct: 881  -----VNGHR---HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA-LC 931

Query: 2162 DDFLGQLPHGRVLLP---------LNLQLGAKVS---------------------FVCDE 2191
              ++ Q   G VL P         LN     +VS                      + ++
Sbjct: 932  GGYI-QGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITED 990

Query: 2192 G------FRLKGRSASHCVLAGMKALWNSSVPVCEQIF-----------------CPNPP 2228
            G       RL G    H + AG+   + + +                        C +P 
Sbjct: 991  GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPG 1050

Query: 2229 AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAP 2288
                 R  G  FG    G  ++++C       + + L G + + C     G  VWS+P P
Sbjct: 1051 VPAFSRRIGFHFG---VGDSLTFSC------FLGYRLEGATKLTCLGG--GRRVWSAPLP 1099

Query: 2289 RC 2290
            RC
Sbjct: 1100 RC 1101



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 112/505 (22%), Positives = 171/505 (33%), Gaps = 99/505 (19%)

Query: 69   LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128
            L +  + G S R F  +         A  R     C + P+P  G   +      GS ++
Sbjct: 1714 LRFSAKSGASARGFHFVYQ-------AVPRTSDTQCSSVPEPRYGR-RIGSEFSAGSIVR 1765

Query: 129  YSCTKGYRLIGSSSATC-IISGDTVIWDNETPICDRIPCGLPPTITNGDFIST------- 180
            + C  GY L GS++  C  +      W++  P C  +PC    T   G  +S        
Sbjct: 1766 FECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV-VPCSGNFTQRRGTILSPGYPEPYG 1824

Query: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG---PAPQCIIPNK 237
            N  N  +  +VT     GSG +     +   S     N D + I  G    AP+    + 
Sbjct: 1825 NNLNCIWKIIVT----EGSGIQ-----IQVISFATEQNWDSLEIHDGGDVTAPRLGSFSG 1875

Query: 238  CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 297
             T P + N    S+   L   +++           K      CQ     EP LPS S   
Sbjct: 1876 TTVPALLNS--TSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQ-----EPALPSNSI-- 1926

Query: 298  QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP--QGDWSPAAPTCEV 355
                         +  D +     + + CEPGY L+G + + C P     W+  +P C +
Sbjct: 1927 -------------KIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-I 1972

Query: 356  KSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 415
             +C   +   L G +L P                    G   SY     ++  W  S+P+
Sbjct: 1973 ATCGGTL-STLGGVILSP--------------------GFPGSY--PNNLDCTWRISLPI 2009

Query: 416  CEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDL-------IGESTI 468
                            H    ++  P      Y   P   + +  DL         E+ I
Sbjct: 2010 GYGAHIQFLNFSTEANHDFLEIQNGP------YHTSPMIGQFSGTDLPAALLSTTHETLI 2063

Query: 469  RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY- 527
               SD   N      A +   L +C  P  F    +      SD+ +G S+ +EC P Y 
Sbjct: 2064 HFYSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYMIN----SDYSVGQSVSFECYPGYI 2119

Query: 528  -YGRPFSITCLD--NLVWSSPKDVC 549
              G P  +TC    N  W+ P   C
Sbjct: 2120 LIGHPV-LTCQHGINRNWNYPFPRC 2143



 Score = 35.8 bits (81), Expect = 0.54
 Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 22/116 (18%)

Query: 389 GFQLKGSSASYCVLAGMESLW-NSSVPVCEQIFCPSPPVIPNGRHT-GKPLEV------- 439
           GFQL  S  S      + +LW  +   V  Q F     V+P+  HT G P E+       
Sbjct: 104 GFQLPSSIVS---TGSILTLWFTTDFAVSAQGFKALYEVLPS--HTCGNPGEILKGVLHG 158

Query: 440 --FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493
             F  G  + Y+C P       + L G + + C   P     W  PAP C   G C
Sbjct: 159 TRFNIGDKIRYSCLP------GYILEGHAILTCIVSPGNGASWDFPAPFCRAEGAC 208



 Score = 35.8 bits (81), Expect = 0.54
 Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 22/116 (18%)

Query: 839 GFQLKGSSASYCVLAGMESLW-NSSVPVCEQIFCPSPPVIPNGRHT-GKPLEV------- 889
           GFQL  S  S      + +LW  +   V  Q F     V+P+  HT G P E+       
Sbjct: 104 GFQLPSSIVS---TGSILTLWFTTDFAVSAQGFKALYEVLPS--HTCGNPGEILKGVLHG 158

Query: 890 --FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 943
             F  G  + Y+C P       + L G + + C   P     W  PAP C   G C
Sbjct: 159 TRFNIGDKIRYSCLP------GYILEGHAILTCIVSPGNGASWDFPAPFCRAEGAC 208



 Score = 35.8 bits (81), Expect = 0.54
 Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 22/116 (18%)

Query: 1289 GFQLKGSSASYCVLAGMESLW-NSSVPVCEQIFCPSPPVIPNGRHT-GKPLEV------- 1339
            GFQL  S  S      + +LW  +   V  Q F     V+P+  HT G P E+       
Sbjct: 104  GFQLPSSIVS---TGSILTLWFTTDFAVSAQGFKALYEVLPS--HTCGNPGEILKGVLHG 158

Query: 1340 --FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 1393
              F  G  + Y+C P       + L G + + C   P     W  PAP C   G C
Sbjct: 159  TRFNIGDKIRYSCLP------GYILEGHAILTCIVSPGNGASWDFPAPFCRAEGAC 208



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 15/71 (21%)

Query: 294 SRVCQPPPD----VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ----GD 345
           S  C  P +    VLH  R       F+ G ++ YSC PGY L G A + C         
Sbjct: 142 SHTCGNPGEILKGVLHGTR-------FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGAS 194

Query: 346 WSPAAPTCEVK 356
           W   AP C  +
Sbjct: 195 WDFPAPFCRAE 205



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 10/57 (17%)

Query: 2379 HYGDY-----VTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSG 2430
            H GD+     VT  C+ GYTL       C+ + +W+  L  C     DAL  G + G
Sbjct: 886  HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC-----DALCGGYIQG 937


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  310 bits (794), Expect = 1e-83
 Identities = 341/1328 (25%), Positives = 550/1328 (41%), Gaps = 177/1328 (13%)

Query: 27   LLAVVVLLALPVAWGQCNAPEW--LPFARPTNLT----DEFEFPIGTYLNYECRPGYSGR 80
            LLA ++ L L   W  C A +   LP  R T +      +  +P GT   Y+CRPGY   
Sbjct: 3    LLAKIICLML---WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSL 59

Query: 81   PFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVHVIKG--IQFGSQIKYSCTKGYR 136
               I+  +   W       +C+++ C +P D   G   +  G   ++G +  Y+C +GY+
Sbjct: 60   GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119

Query: 137  LIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTI-TNGDFISTNRE---NFHYGSVVT 192
            L+G  +       DT  W N+ PIC+ + C LP T   NG  +S+  E    +H+G  V 
Sbjct: 120  LLGEINYR---ECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175

Query: 193  YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
            + CN G      +++ G+  ++C+ +    G WS   P+C +   C  P+V NG  +S  
Sbjct: 176  FVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC-VEISCKSPDVINGSPIS-Q 223

Query: 253  RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 312
            + ++  NE  +++C  G+         C   + W P LPSC       P + + + +   
Sbjct: 224  KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL- 280

Query: 313  KDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPTCEVKSCD--DFM-GQLLN- 367
            +     G E+ Y C  G Y      + +CT  G W P AP C +K CD  D   G L + 
Sbjct: 281  RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHE 338

Query: 368  --GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCEQIFCP 422
               R  FPV   +G    + CDE F+    S     +C   G    W+ +VP   + + P
Sbjct: 339  NMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVPCLRKCYFP 392

Query: 423  SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482
                  N  H  K    F  GK+++  C P    G +     ++T+ C      NG W S
Sbjct: 393  YLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK-AQTTVTCME----NG-W-S 437

Query: 483  PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY----GRPFSITCLD 538
            P PRC  +  C      +     +++  + + +    KY+C+  Y         SITC  
Sbjct: 438  PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGK 496

Query: 539  NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 598
            +  WS+ +  C  KSC  P        +  T  ++   ++Y C  G+     S+   I+ 
Sbjct: 497  D-GWSA-QPTC-IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVC 553

Query: 599  GNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELV 658
            G    WS   PIC    C L P I         ++ +  G V+ + C PG      F +V
Sbjct: 554  GYNG-WSDL-PICYERECEL-PKIDVHLVPDRKKDQYKVGEVLKFSCKPG------FTIV 604

Query: 659  GEPSIYCTSNDDQVGIWSGPAPQC--IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 716
            G  S+ C       G+ S   P C   + +   PP + NG +    +  +  +EVVE+ C
Sbjct: 605  GPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYC 659

Query: 717  QPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
             P F+MKGP +++C    +W   LP C      C   P++ H    Q     +  G  V 
Sbjct: 660  NPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVE 716

Query: 774  YSCEPGYDLRGAASMRCTPQGDWSPAAPTC----EVKSCDDFMGQLLNGRVLFPVNLQLG 829
            ++C   + + G  S+ C   G W+   P C    ++K C        +  ++   +L+  
Sbjct: 717  FNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS------SNLIILEEHLKNK 768

Query: 830  AKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
             + D   +  ++ +G      + C+    +   N S+   +   CP PP IPN  +    
Sbjct: 769  KEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQ--LCPPPPQIPNSHNMTTT 826

Query: 887  LEVFPFGKTVNYTCDPHPDRGTSFDLIGE-STIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
            L  +  G+ V+  C  +        LI E   I C      +G W S  P C     C  
Sbjct: 827  LN-YRDGEKVSVLCQEN-------YLIQEGEEITCK-----DGRWQS-IPLCVEKIPCSQ 872

Query: 946  PDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSC 1004
            P       + +  ++ + +  GT L Y C   +     + T      WSSP   C+   C
Sbjct: 873  PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQ-CEGLPC 931

Query: 1005 KTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063
            K+PP+  +G+V H+    Q G  + Y C  G  + G + A+C+       WS  PP C +
Sbjct: 932  KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEKWS-HPPSCIK 986

Query: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
              C   P+  N   +   ++ +  G  VTY C         +++ G  ++ C ++     
Sbjct: 987  TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVTCINSR---- 1036

Query: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183
             W+G  P C   +   PP V+N  +VS   S +   E V ++C+  + M G   V C   
Sbjct: 1037 -WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG 1094

Query: 1184 NKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 1240
            N  EP  P C   +  C PPP + + + T      ++P   V Y C+  Y L G   + C
Sbjct: 1095 NWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152

Query: 1241 TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQL------------GAKVDFVCDE 1288
               G WS   P C +  C      +++  ++   N+ L            G  V+FVC  
Sbjct: 1153 R-NGQWS-EPPKC-LHPC------VISREIMENYNIALRWTAKQKLYSRTGESVEFVCKR 1203

Query: 1289 GFQLKGSS 1296
            G++L   S
Sbjct: 1204 GYRLSSRS 1211



 Score =  295 bits (756), Expect = 3e-79
 Identities = 328/1286 (25%), Positives = 527/1286 (40%), Gaps = 164/1286 (12%)

Query: 513  FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 570
            +P GT   Y+CRP Y   G    +      V  +P   C+++ C  P D   G   +   
Sbjct: 42   YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101

Query: 571  --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTIA-NGD 626
               + G +  Y+C  G++L+G  +  EC   G    W+   PIC+ + C LP T   NG 
Sbjct: 102  NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156

Query: 627  FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
             +S+  E    +H+G  V + CN G      +++ G+  ++C+ +    G WS   P+C+
Sbjct: 157  IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKCV 206

Query: 684  IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
                C  P+V NG  +S  + ++  NE  +++C  G+         C   + W P LPSC
Sbjct: 207  -EISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262

Query: 744  SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 802
                   P + + + +   +     G E+ Y C  G Y      + +CT  G W PA P 
Sbjct: 263  EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PR 319

Query: 803  CEVKSCDDFMGQLLNG--------RVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCV 851
            C +K CD     + +G        R  FPV   +G    + CDE F+    S     +C 
Sbjct: 320  CTLKPCD--YPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCT 375

Query: 852  LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 911
              G    W+ +VP   + + P      N  H  K    F  GK+++  C P    G +  
Sbjct: 376  QDG----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALP 423

Query: 912  LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 971
               ++T+ C      NG WS P PRC  +  C      +     +++  + + +    KY
Sbjct: 424  K-AQTTVTCME----NG-WS-PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKY 475

Query: 972  ECRPEYYGRPF----SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1027
            +C+  Y         SITC  +   + P  +   KSC  P        +  T  ++   +
Sbjct: 476  QCKLGYVTADGETSGSITCGKDGWSAQPTCI---KSCDIPVFMNARTKNDFTWFKLNDTL 532

Query: 1028 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHY 1087
            +Y C  G+     S+   I+ G    WS  P IC    C LP    +       ++ +  
Sbjct: 533  DYECHDGYESNTGSTTGSIVCGYNG-WSDLP-ICYERECELPKIDVHL-VPDRKKDQYKV 589

Query: 1088 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--IPNKCTPPNVEN 1145
            G V+ + C PG      F +VG  S+ C       G+ S   P C   + +   PP + N
Sbjct: 590  GEVLKFSCKPG------FTIVGPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLN 638

Query: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPD 1202
            G +    +  +  +EVVE+ C P F+MKGP +++C    +W   LP C      C   P+
Sbjct: 639  GNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPE 696

Query: 1203 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC----EVKSC 1258
            + H    Q     +  G  V ++C   + + G  S+ C   G W+   P C    ++K C
Sbjct: 697  LEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKC 753

Query: 1259 DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNSSVPV 1315
                    +  ++   +L+   + D   +  ++ +G      + C+    +   N S+  
Sbjct: 754  KS------SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQ 807

Query: 1316 CEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE-STIRCTSDP 1374
             +   CP PP IPN  +    L  +  G+ V+  C  +        LI E   I C    
Sbjct: 808  IQ--LCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQEN-------YLIQEGEEITCK--- 854

Query: 1375 QGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPFS 1433
              +G W S  P C     C  P       + +  ++ + +  GT L Y C   +     +
Sbjct: 855  --DGRWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEEN 911

Query: 1434 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSS 1492
             T      WSSP   C+   CK+PP+  +G+V H+    Q G  + Y C  G  + G + 
Sbjct: 912  ETTCYMGKWSSPPQ-CEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAI 970

Query: 1493 AECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGR 1552
            A+C+       WS  PP C +  C   P+  N   +   ++ +  G  VTY C       
Sbjct: 971  AKCL----GEKWS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------A 1019

Query: 1553 KVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVV 1612
              +++ G  ++ C ++      W+G  P C   +   PP V+N  +VS   S +   E V
Sbjct: 1020 TYYKMDGASNVTCINSR-----WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERV 1073

Query: 1613 EFRCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPEILHGEHTPSHQDNFSPG 1669
             ++C+  + M G   V C   N  EP  P C   +  C PPP I +G+ T      ++P 
Sbjct: 1074 RYQCRSPYEMFGDEEVMCLNGNWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPA 1131

Query: 1670 QEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------P 1723
              V Y C+  Y L G   + C   G WS E P+C +  C      + +  +         
Sbjct: 1132 SSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQK 1188

Query: 1724 LNLQLGAKVSFVCDEGFRLKGSSVSH 1749
            L  + G  V FVC  G+RL  SS SH
Sbjct: 1189 LYSRTGESVEFVCKRGYRL--SSRSH 1212



 Score =  290 bits (743), Expect = 9e-78
 Identities = 329/1273 (25%), Positives = 489/1273 (38%), Gaps = 203/1273 (15%)

Query: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI--CQRIPCGLPPTIANGDFISTN 1081
            G++  Y C  G+R +G+    C        W    P+  CQ+ PCG P     G F  T 
Sbjct: 45   GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100

Query: 1082 RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1141
               F YG    Y CN G      ++L+GE +      D     W+   P C +  KC P 
Sbjct: 101  GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG----WTNDIPICEVV-KCLPV 149

Query: 1142 NV-ENGILVSDNRSL---FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
               ENG +VS        +   + V F C  G+ ++G   + C     W  E P C  + 
Sbjct: 150  TAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEIS 209

Query: 1198 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 1257
               PDV++     + K  +   +   Y C  GY+        CT  G W P  P+CE KS
Sbjct: 210  CKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPL-PSCEEKS 266

Query: 1258 CDDFMGQLLNGRVL-FPVNLQLGAKVDFVCDEGFQ--LKGSSASYCVLAGMESLWNSSVP 1314
            CD+    + NG      +  + G ++ + C  GF    +G++A  C   G    W  + P
Sbjct: 267  CDN--PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG----WIPA-P 318

Query: 1315 VCEQIFCPSPPVIPNGR-HTGKPLEVFPF--GKAVNYTCDPHPDR--GTSFDLIGESTIR 1369
             C    C  P +   G  H       FP   GK  +Y CD H +   G+ +D      I 
Sbjct: 319  RCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWD-----HIH 373

Query: 1370 CTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY- 1428
            CT D      WS PA  C  L  C  P          Q +   F  G S+   C P Y  
Sbjct: 374  CTQDG-----WS-PAVPC--LRKCYFP---YLENGYNQNHGRKFVQGKSIDVACHPGYAL 422

Query: 1429 -GRPFSITCLDNLVWSSPKDVCKRKSC-KTPPDPVNGMVHVIT-DIQVGSRINYSCTTGH 1485
                 ++TC++N  WS      + K+C K+  D  NG +        +  +  Y C  G+
Sbjct: 423  PKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGY 481

Query: 1486 RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNREN----FHYGSVV 1541
                  ++  I  G    WS +P   +   C +P       F++   +N    F     +
Sbjct: 482  VTADGETSGSITCGKDG-WSAQPTCIKS--CDIPV------FMNARTKNDFTWFKLNDTL 532

Query: 1542 TYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSD 1601
             Y C+ G          G  SI C  N      WS   P C    +C  P ++  ++   
Sbjct: 533  DYECHDGYESN-TGSTTG--SIVCGYNG-----WSD-LPICY-ERECELPKIDVHLVPDR 582

Query: 1602 NRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS---RVCQPPPEILHGEH 1658
             +  + + EV++F C+PGF + GP  V+C       P+LP C    + C PPPE+L+G  
Sbjct: 583  KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNV 641

Query: 1659 TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVK--SCDDFLGQLP 1716
                ++ +   + V Y C P + ++G   + C   G+W+   P C V+  +C D + +L 
Sbjct: 642  KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGD-IPELE 698

Query: 1717 HGRV-LFPLNLQLGAKVSFVCDEGFRLKG-----------SSVSHCVLVGM--RSLWNNS 1762
            HG   L       G  V F C E F + G           + +  CV +    +   +N 
Sbjct: 699  HGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNL 758

Query: 1763 VPVCEHI--------------------------------------------FCPNPPAIL 1778
            + + EH+                                             CP PP I 
Sbjct: 759  IILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIP 818

Query: 1779 NGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGEST-IRCTSDPHGNGVWSSPAPRC 1837
            N  H  T + +   G+++S  C  +        LI E   I C      +G W S  P C
Sbjct: 819  NS-HNMTTTLNYRDGEKVSVLCQEN-------YLIQEGEEITCK-----DGRWQS-IPLC 864

Query: 1838 ELSVRAGHCKTPEQFPFASPTIPINDFE-FPVGTSLNYECRPGY-FGKMFSISCLENLVW 1895
               V    C  P Q    +     +  E +  GT L+Y C  G+   +    +C     W
Sbjct: 865  ---VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-W 920

Query: 1896 SSVEDNCRRKSCGPPPEPFNGMV-HINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNN 1954
            SS    C    C  PPE  +G+V H++   Q+G  V Y C EGF + G     CL     
Sbjct: 921  SS-PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----G 975

Query: 1955 VTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
              W    P C    C   P+  N       +  +  G  VTY C T       +++ G  
Sbjct: 976  EKWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT------YYKMDGAS 1028

Query: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
            ++ C +       W+  P  C  T+    P V+NA  V    S +   E +R++C+  + 
Sbjct: 1029 NVTCINSR-----WTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYE 1082

Query: 2075 MVGSHTVQCQTNGRWG--PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPS 2132
            M G   V C  NG W   P+    +  C PPP I +G+ T      ++P   V Y C+  
Sbjct: 1083 MFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 1141

Query: 2133 YDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL------PLNLQLGAKVS 2186
            Y L G   + C   G WS E P+C +  C      + +  + L       L  + G  V 
Sbjct: 1142 YQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVE 1198

Query: 2187 FVCDEGFRLKGRS 2199
            FVC  G+RL  RS
Sbjct: 1199 FVCKRGYRLSSRS 1211



 Score =  257 bits (656), Expect = 1e-67
 Identities = 318/1275 (24%), Positives = 507/1275 (39%), Gaps = 173/1275 (13%)

Query: 160  ICDRIPCGLPPTITNGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
            IC    C   P   N + +  S + + +  G+   Y+C PG      +  +G   + C  
Sbjct: 15   ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68

Query: 218  NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
             +    +   P  +C       P +   G       ++F       + C  G+ + G   
Sbjct: 69   GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125

Query: 278  VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
             +    + W  ++P C  V C P   P +             +  GQ V + C  GY + 
Sbjct: 126  YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185

Query: 334  GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
            G   M C+  G WS   P C   SC   D   G  ++ ++++  N     +  + C+ G+
Sbjct: 186  GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241

Query: 391  QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 449
            +      + C  +G   L     P CE+  C + P IPNG ++  PL +    G  + Y 
Sbjct: 242  EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293

Query: 450  CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
            C     R   +     +T +CTS       W  PAPRC  L  C  PD            
Sbjct: 294  C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341

Query: 510  ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
               FP  +G    Y C  E++  P       I C  +  W SP   C RK      +   
Sbjct: 342  RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398

Query: 563  GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKPPICQRIPCGLPPT 621
               H    +Q G  I+ +C  G+ L    ++  C+ +G    WS  P   +   C     
Sbjct: 399  NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTPRCIRVKTCSKSSI 453

Query: 622  IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
                 FIS ++  +       Y+C  G          GE S   T   D    WS   P 
Sbjct: 454  DIENGFISESQYTYALKEKAKYQCKLG-----YVTADGETSGSITCGKDG---WSA-QPT 504

Query: 682  CIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF---VMKGPRRVKCQALNKWEP 738
            CI    C  P   N    +D  + F LN+ +++ C  G+          + C   N W  
Sbjct: 505  CI--KSCDIPVFMNARTKND-FTWFKLNDTLDYECHDGYESNTGSTTGSIVC-GYNGWS- 559

Query: 739  ELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
            +LP C  R C+ P   +H     R KD +  G+ + +SC+PG+ + G  S++C   G  S
Sbjct: 560  DLPICYERECELPKIDVHLV-PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LS 617

Query: 798  PAAPTC--EVKSCDDFMGQLLNGRVLFPVNLQLGAK--VDFVCDEGFQLKGSSASYCVLA 853
            P  P C  +V+SC     +LLNG V      + G    V++ C+  F +KG +   CV  
Sbjct: 618  PDLPICKEQVQSCGP-PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-- 674

Query: 854  GMESLWNSSVPVC--EQIFCPSPPVIPNG-RHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 910
              +  W +++PVC  E+  C   P + +G      P   + +G +V + C        SF
Sbjct: 675  --DGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSP--PYYYGDSVEFNC------SESF 723

Query: 911  DLIGESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDHFLFAK-LKTQTNASDFPIG 966
             +IG  +I C      +GVW+   P+C     L  C++ +  +  + LK   N  +F   
Sbjct: 724  TMIGHRSITCI-----HGVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLK---NKKEFDHN 774

Query: 967  TSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQV 1023
            ++++Y CR +     +  T   N  W    +    +    PP P     H +T   + + 
Sbjct: 775  SNIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRD 831

Query: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIS--TN 1081
            G +++  C   + +       C        W + P   ++IPC  PP I +G   S  ++
Sbjct: 832  GEKVSVLCQENYLIQEGEEITC----KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSS 887

Query: 1082 RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTP 1140
            +E++ +G+ ++Y C  G      F +  E    C      +G WS P PQC  +P K +P
Sbjct: 888  QESYAHGTKLSYTCEGG------FRISEENETTC-----YMGKWSSP-PQCEGLPCK-SP 934

Query: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQP 1199
            P + +G++   + S +   E V ++C  GF + GP   KC    KW    PSC +  C  
Sbjct: 935  PEISHGVVAHMSDS-YQYGEEVTYKCFEGFGIDGPAIAKCLG-EKWS-HPPSCIKTDCLS 991

Query: 1200 PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD 1259
             P   +A      KD +  G++V Y+C   Y + GA+++ C     W+   PTC   SC 
Sbjct: 992  LPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWT-GRPTCRDTSCV 1049

Query: 1260 DFMGQLLNGRVLFPVNLQL-----GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVP 1314
            +    + N  +   V+ Q+     G +V + C   +++ G     C    +   W +  P
Sbjct: 1050 N-PPTVQNAYI---VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC----LNGNW-TEPP 1100

Query: 1315 VCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTS 1372
             C+     C  PP I NG  T  PL V+    +V Y C         + L G   I C  
Sbjct: 1101 QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR- 1153

Query: 1373 DPQGNGVWSSPAPRC 1387
                NG WS P P+C
Sbjct: 1154 ----NGQWSEP-PKC 1163



 Score =  221 bits (562), Expect = 9e-57
 Identities = 301/1227 (24%), Positives = 479/1227 (39%), Gaps = 198/1227 (16%)

Query: 1279 GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV--CEQIFCPSPPVIPNGRHTGKP 1336
            G +  + C  G++  G+    C     +  W +  P+  C++  C  P   P G  T   
Sbjct: 45   GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100

Query: 1337 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAPRCGILG--HC 1393
              VF +G    YTC+        + L+GE   R C +D      W++  P C ++     
Sbjct: 101  GNVFEYGVKAVYTCNE------GYQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149

Query: 1394 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK 1452
             AP++        + +  ++  G ++++ C   Y       + C D+  WS  K  C   
Sbjct: 150  TAPENGKIVSSAMEPDR-EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208

Query: 1453 SCKTPPDPVNGM-VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC 1511
            SCK+P D +NG  +      +   R  Y C  G+       A C  SG    W   P  C
Sbjct: 209  SCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLPS-C 262

Query: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
            +   C   P I NGD+ S  R     G  +TY+C  G      +      +  CTS    
Sbjct: 263  EEKSCD-NPYIPNGDY-SPLRIKHRTGDEITYQCRNG-----FYPATRGNTAKCTSTG-- 313

Query: 1572 VGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPGFVMKGPR- 1626
               W  PAP+C +   C  P++++G L  +N  R  F  ++ +   + C   F       
Sbjct: 314  ---WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSY 368

Query: 1627 --RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG 1684
               + C   + W P +P C R C  P   L   +  +H   F  G+ +  +C PGY L  
Sbjct: 369  WDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPK 424

Query: 1685 AASLHCTPQGDWSPEAPRCA-VKSCDDFLGQLPHGRVL-FPLNLQLGAKVSFVCDEGFRL 1742
            A +     +  WSP  PRC  VK+C      + +G +        L  K  + C  G+  
Sbjct: 425  AQTTVTCMENGWSP-TPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVT 483

Query: 1743 KGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDP 1802
                 S  +  G +  W+ + P C  I   + P  +N R       D  + K ++ T D 
Sbjct: 484  ADGETSGSITCG-KDGWS-AQPTC--IKSCDIPVFMNAR----TKNDFTWFK-LNDTLDY 534

Query: 1803 HPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1862
                G   N  G +T       +G   WS   P C        C+ P+      P    +
Sbjct: 535  ECHDGYESNT-GSTTGSIVCGYNG---WSD-LPICY----ERECELPKIDVHLVPDRKKD 585

Query: 1863 DFEFPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRK--SCGPPPEPFNGMVH 1919
             ++  VG  L + C+PG+      S+ C  +   S     C+ +  SCGPPPE  NG V 
Sbjct: 586  QYK--VGEVLKFSCKPGFTIVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLNGNVK 642

Query: 1920 INTDTQFGST--VNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC--EIISCEPPPTI 1975
              T  ++G +  V Y CN  F + G     C V G   T     P+C  E  +C   P +
Sbjct: 643  EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWTT----LPVCIVEESTCGDIPEL 697

Query: 1976 SNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035
             +G +   +   ++ G  V + C       + F ++G RSI C       GVW+  P +C
Sbjct: 698  EHG-WAQLSSPPYYYGDSVEFNC------SESFTMIGHRSITCIH-----GVWTQLP-QC 744

Query: 2036 ISTNKCTAPEVENAIRVPG---NRSFFTLTEIIRFRCQ---------------------- 2070
            ++ +K    +  N I +     N+  F     IR+RC+                      
Sbjct: 745  VAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCS 804

Query: 2071 --------PGFVMVGSH--------------TVQCQTN-------------GRWGPKLPH 2095
                    P   +  SH              +V CQ N             GRW   +P 
Sbjct: 805  MAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRW-QSIPL 863

Query: 2096 CSRV--CQPPPEILHG--EHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 2151
            C     C  PP+I HG    + S Q++++ G ++ Y+CE  + +       C   G WS 
Sbjct: 864  CVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWS- 921

Query: 2152 EAPRCTVKSCDDFLGQLPHGRVL-LPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 2210
              P+C    C     ++ HG V  +  + Q G +V++ C EGF + G + + C+  G K 
Sbjct: 922  SPPQCEGLPCKS-PPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL--GEK- 977

Query: 2211 LWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESS 2270
             W S  P C +  C + P+  N    G        G++++Y C T+      + + G S+
Sbjct: 978  -W-SHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATY------YKMDGASN 1029

Query: 2271 IRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPG 2330
            + C      N  W+   P C      +C +PP +QN + +   +S Y  G  + Y C   
Sbjct: 1030 VTCI-----NSRWTG-RPTCR---DTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSP 1080

Query: 2331 YLLVGKGFIFCTDQGIWSQLDHYCKEV--NCSFPLFMNGISKELEMKKVYHYGDYVTLKC 2388
            Y + G   + C + G W++    CK+    C  P  ++          VY     V  +C
Sbjct: 1081 YEMFGDEEVMCLN-GNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 1138

Query: 2389 EDGYTLEGSPWSQCQADDRWDPPLAKC 2415
            ++ Y LEG+    C+     +PP  KC
Sbjct: 1139 QNLYQLEGNKRITCRNGQWSEPP--KC 1163



 Score =  186 bits (472), Expect = 2e-46
 Identities = 235/976 (24%), Positives = 374/976 (38%), Gaps = 141/976 (14%)

Query: 1510 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
            IC    C   P   N + +  S + + +  G+   Y+C  G R       +G   + C  
Sbjct: 15   ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCRK 68

Query: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627
             +    +   P  +C       P +   G       ++F       + C  G+ + G   
Sbjct: 69   GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125

Query: 1628 VKCQALNKWEPELPSCSRV-CQP--PPE---ILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681
             +    + W  ++P C  V C P   PE   I+     P  + +F  GQ V + C  GY 
Sbjct: 126  YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF--GQAVRFVCNSGYK 183

Query: 1682 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738
            + G   +HC+  G WS E P+C   SC   D   G     ++++  N     +  + C+ 
Sbjct: 184  IEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNM 239

Query: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
            G+       + C   G R L     P CE   C N P I NG ++         G EI+Y
Sbjct: 240  GYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH-RTGDEITY 292

Query: 1799 TCDP--HP-DRGMTFNLIGESTI---RCTSDP-------HGNGVWSSPAPRCELSVRAG- 1844
             C    +P  RG T        I   RCT  P       HG G++     R    V  G 
Sbjct: 293  QCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHG-GLYHENMRRPYFPVAVGK 351

Query: 1845 --------HCKTPEQFPFA---------SPTIPI----------------NDFEFPVGTS 1871
                    H +TP    +          SP +P                 +  +F  G S
Sbjct: 352  YYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKS 411

Query: 1872 LNYECRPGYF--GKMFSISCLENLVWSSVEDNCRRKSCGPPP-EPFNGMVHINTDT-QFG 1927
            ++  C PGY       +++C+EN  WS      R K+C     +  NG +  +  T    
Sbjct: 412  IDVACHPGYALPKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALK 470

Query: 1928 STVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTS 1987
                Y C  G+      ++  +  G +  W  + P C I SC+ P  ++      N+ T 
Sbjct: 471  EKAKYQCKLGYVTADGETSGSITCGKD-GWSAQ-PTC-IKSCDIPVFMNART--KNDFTW 525

Query: 1988 FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVE 2047
            F     + Y+CH   DG +        SI C         WS  P       +C  P+++
Sbjct: 526  FKLNDTLDYECH---DGYESNTGSTTGSIVCGYNG-----WSDLP--ICYERECELPKID 575

Query: 2048 NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS---RVCQPPP 2104
              +     +  + + E+++F C+PGF +VG ++VQC   G   P LP C    + C PPP
Sbjct: 576  VHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPP 634

Query: 2105 EILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVK--SCD 2162
            E+L+G      ++ +   + V Y C P + ++G   + C   G+W+   P C V+  +C 
Sbjct: 635  ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIVEESTCG 692

Query: 2163 DFLGQLPHGRVLLPL-NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQ 2221
            D + +L HG   L       G  V F C E F + G  +  C+      +W + +P C  
Sbjct: 693  D-IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI----HGVW-TQLPQCVA 746

Query: 2222 I----FCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDP 2277
            I     C +   I+   H      +  +   I Y C     RG      G     C    
Sbjct: 747  IDKLKKCKSSNLIILEEHLKNK-KEFDHNSNIRYRC-----RGKE----GWIHTVCI--- 793

Query: 2278 QGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKG 2337
              NG W  P   C ++    CP PP+I N H +   ++ Y  G  +S +C   YL+    
Sbjct: 794  --NGRW-DPEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGE 849

Query: 2338 FIFCTDQGIWSQLDHYCKEVNCSFP--LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLE 2395
             I C D G W  +    +++ CS P  +    I+     ++ Y +G  ++  CE G+ + 
Sbjct: 850  EITCKD-GRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS 908

Query: 2396 GSPWSQCQADDRWDPP 2411
                + C    +W  P
Sbjct: 909  EENETTCYM-GKWSSP 923



 Score = 98.2 bits (243), Expect = 9e-20
 Identities = 82/323 (25%), Positives = 137/323 (42%), Gaps = 37/323 (11%)

Query: 43   CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRK 102
            C +P  +      +++D +++  G  + Y+C  G+     +I       W+     C + 
Sbjct: 931  CKSPPEISHGVVAHMSDSYQY--GEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPS-CIKT 987

Query: 103  SCRNPPD-----PVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
             C + P      P+     V K    G Q+ Y+C   Y++ G+S+ TCI S     W   
Sbjct: 988  DCLSLPSFENAIPMGEKKDVYKA---GEQVTYTCATYYKMDGASNVTCINSR----WTGR 1040

Query: 158  TPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
             P C    C  PPT+ N   +S     +  G  V Y+C      R  +E+ G+  + C +
Sbjct: 1041 -PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQC------RSPYEMFGDEEVMCLN 1093

Query: 218  NDDQVGIWSGPAPQCI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275
                 G W+ P PQC     KC  PP ++NG + S   S+++    VE++CQ  + ++G 
Sbjct: 1094 -----GNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 1147

Query: 276  RRVKCQALNKWEPELPSCSRVCQPPPDVLHAER-----TQRDKDNFSPGQEVFYSCEPGY 330
            +R+ C+   +W  E P C   C    +++         T + K     G+ V + C+ GY
Sbjct: 1148 KRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGY 1205

Query: 331  DLRGAASMRCTPQGDWSPAAPTC 353
             L   +    T   D     PTC
Sbjct: 1206 RLSSRSHTLRTTCWDGKLEYPTC 1228



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 32/248 (12%)

Query: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV--CEQIFCPNPPAILNGRHTGTP 2239
            G +  + C  G+R    S  + ++   K  W +  P+  C++  C +P     G  T T 
Sbjct: 45   GTQAIYKCRPGYR----SLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCEL--SVPA 2296
                 YG +  Y C+        + L+GE + R C +D      W++  P CE+   +P 
Sbjct: 101  GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149

Query: 2297 ACPHPPKIQNGHYIGGHVSL---YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 2353
              P     +NG  +   +     Y  G  + ++C+ GY + G   + C+D G WS+    
Sbjct: 150  TAP-----ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPK 204

Query: 2354 CKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLA 2413
            C E++C  P  +NG    +  K +Y   +    KC  GY       + C  +  W  PL 
Sbjct: 205  CVEISCKSPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLP 260

Query: 2414 KCTSRTHD 2421
             C  ++ D
Sbjct: 261  SCEEKSCD 268


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score =  282 bits (721), Expect = 3e-75
 Identities = 313/1226 (25%), Positives = 457/1226 (37%), Gaps = 226/1226 (18%)

Query: 1002 KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 1061
            + C  P    NG+V       VG  + + C  G++L GH    C   G   +W    P C
Sbjct: 2121 QECPDPEPFANGIVRG-AGYNVGQSVTFECLPGYQLTGHPVLTC-QHGTNRNWDHPLPKC 2178

Query: 1062 QRIPCGLPPTIANGDFISTNRENFHYGS---VVTYRCNPGSGGRKVFELVG-EPSIYCTS 1117
            + +PCG   T +NG   S    + +  S   V       G G R    L+  EPS     
Sbjct: 2179 E-VPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPS----- 2232

Query: 1118 NDDQVGIWSGP---APQCII---------------------------------------P 1135
              D + IW GP   AP+  +                                        
Sbjct: 2233 -GDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPL 2291

Query: 1136 NKCTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ--ALNKWEPELPS 1192
             KC PP +  N  +V++N   F++ ++V +RC PGF + G   + C+     ++E   P 
Sbjct: 2292 TKCPPPTILPNAEVVTENEE-FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPI 2350

Query: 1193 CSRVCQPPPDVLHAERTQRDKDNFSPGQ-EVFYSC------EPGYDLR------------ 1233
            C   C  P + L  + T        PG    F +C      EP Y++             
Sbjct: 2351 CEVHC--PTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQY 2408

Query: 1234 ----------GAASMRCTPQGDWSP------------------------------AAPTC 1253
                      G + +     G++S                               +AP C
Sbjct: 2409 DEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC 2468

Query: 1254 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSS 1312
             +          L+G +L   + Q G  + F C+ G++L G S + C        LW+ +
Sbjct: 2469 SLPRAP------LHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEA 2522

Query: 1313 VPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTS 1372
            +P+C+ + C  P    NG   GK   V   G    Y+C      G       E+T  C  
Sbjct: 2523 IPLCQALSCGLPEAPKNGMVFGKEYTV---GTKAMYSCS----EGYHLQAGAEATAECLD 2575

Query: 1373 DPQGNGVWSSP--APRCGILGHCQAPDHFLFAKLKTQTNA---SDFPIGTSLKYECRPEY 1427
                 G+WS+    P+C  +     PD    +    +      + +     L   C P Y
Sbjct: 2576 ----TGLWSNRNVPPQCVPV---TCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGY 2628

Query: 1428 Y--GRPFSITCLDNLVWS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQV-GSRINYSCT 1482
            Y  G+   I C  N  WS       C+  SC   P P NG  H I  + V G+   +SC 
Sbjct: 2629 YYTGQRV-IRCQANGKWSLGDSTPTCRIISCGELPIPPNG--HRIGTLSVYGATAIFSCN 2685

Query: 1483 TGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVT 1542
            +G+ L+G    EC+ +G    WS     C    CG P  I NG     N EN+ Y   V 
Sbjct: 2686 SGYTLVGSRVRECMANGL---WSGSEVRCLAGHCGTPEPIVNGHI---NGENYSYRGSVV 2739

Query: 1543 YRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 1602
            Y+CN G      F L+G     C  +      WSG  P C++ +   P +  +  +  D+
Sbjct: 2740 YQCNAG------FRLIGMSVRICQQDHH----WSGKTPFCVLVSCGHPGSPPHSQMSGDS 2789

Query: 1603 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR----VCQPPPEILHGEH 1658
               +++  VV + C     + G     C     W   LP CS     VC  P    HG  
Sbjct: 2790 ---YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIR 2846

Query: 1659 TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHG 1718
                 D+F PG  + +SCE G+ LRG++   C   G WS   P C V SC +  G   + 
Sbjct: 2847 LG---DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGN-PGTPSNA 2902

Query: 1719 RVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAIL 1778
            RV+F   L   + + + C EG+   G    HC + G    W  S P C  I C +P    
Sbjct: 2903 RVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG---TWTGSDPECLVINCGDPGIPA 2959

Query: 1779 NGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCE 1838
            NG   G    D  Y K ++Y C P    G        S + CT D      W+   P C 
Sbjct: 2960 NGLRLG---NDFRYNKTVTYQCVP----GYMMESHRVSVLSCTKD----RTWNGTKPVC- 3007

Query: 1839 LSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSI-SCLENLVWSS 1897
               +A  CK P   P       +   +F  G+S+ Y C  GY   + ++ +C  N  W+ 
Sbjct: 3008 ---KALMCKPPPLIPNGK----VVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG 3060

Query: 1898 VEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
                C    CG P  P  G    +    + S+V++SC+    L+GSP   C   G   TW
Sbjct: 3061 ELPQCFPVFCGDPGVPSRGR-REDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDG---TW 3116

Query: 1958 DKKAPIC---EIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
                P C    + +C  P     G    NN   +  G+ V ++C  G      + L G  
Sbjct: 3117 SGTQPSCIDPTLTTCADPGVPQFG--IQNNSQGYQVGSTVLFRCQKG------YLLQGST 3168

Query: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
            +  C         WS  PP C+  + C  PE      V G     ++   + + CQ GF 
Sbjct: 3169 TRTCLPN----LTWSGTPPDCV-PHHCRQPETPTHANV-GALDLPSMGYTLIYSCQEGFS 3222

Query: 2075 MV-GSHTVQCQTNGRWGPKLPHCSRV 2099
            +  GS    C+ +G W  K P C  V
Sbjct: 3223 LKGGSEHRTCKADGSWTGKPPICLEV 3248



 Score =  281 bits (718), Expect = 7e-75
 Identities = 475/2011 (23%), Positives = 721/2011 (35%), Gaps = 363/2011 (18%)

Query: 553  SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
            SC  P  P NG        + G    + C  G+ L G +   C+   N   W   PP C 
Sbjct: 1384 SCNDPGIPQNGS-RSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCI 1442

Query: 613  RIPCGLPPTIANGDFISTNR-ENFHYGSVVTYRC--NPGSGGRKVFELVG-EPS---IYC 665
              PCG   T  +G  +S N  E +  G    ++   +P      VF +   EP    ++ 
Sbjct: 1443 A-PCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHI 1501

Query: 666  TSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVM--- 722
                D +    G      +P          G + S + SLF            GFV+   
Sbjct: 1502 YDGRDSLSPLIGSFYGSQLP----------GRIESSSNSLFLAFRSDASVSNAGFVIDYT 1551

Query: 723  KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 782
            + PR                    C  P  + +  R   D      G  V Y C  GY++
Sbjct: 1552 ENPRES------------------CFDPGSIKNGTRVGSD---LKLGSSVTYYCHGGYEV 1590

Query: 783  RGAASMRCT--PQGD--WSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDE 838
             G +++ C   P G   W+   P C       ++G   +G VL P N         +C  
Sbjct: 1591 EGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGS--DGVVLSP-NYPQNYTSGQICLY 1647

Query: 839  GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIP-NGRHTGKPLEVFPFGKT-V 896
               +      +   A   +  N  V V +     S  +   +G HTG+ L +    +  +
Sbjct: 1648 FVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLI 1707

Query: 897  NYTCDP-HPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 955
             ++     P RG  F  + ++  R TS  Q + V   P PR G                 
Sbjct: 1708 KFSAKGLAPARG--FHFVYQAVPR-TSATQCSSV---PEPRYG----------------- 1744

Query: 956  TQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDN----LVWSSPKDVC---------- 999
             +   SDF +G  +++EC   Y   G P  I CL        W+     C          
Sbjct: 1745 -KRLGSDFSVGAIVRFECNSGYALQGSP-EIECLPVPGALAQWNVSAPTCVVPCGGNLTE 1802

Query: 1000 KRKSCKTP--PDPVNGMVHVI----------TDIQVGSRI-------------------- 1027
            +R +  +P  P+P    ++ +            IQV S +                    
Sbjct: 1803 RRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTM 1862

Query: 1028 --NYSCTTGHRLIGHSSAECIL------SGNAAHWSTKPPICQRIPCGLPPTIANGDFIS 1079
              ++S TT   L+  +S +  L      S +AA +  +        C  P   +NG  + 
Sbjct: 1863 LGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNG--VK 1920

Query: 1080 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 1139
            T  E +    VV+++C PG      + L G   I C      V  W+ P P CI     T
Sbjct: 1921 TG-ERYLVNDVVSFQCEPG------YALQGHAHISCMPGT--VRRWNYPPPLCIAQCGGT 1971

Query: 1140 PPNVENGILVSDNRSLFSLN-----------------EVVEFRCQPGF----VMKGPRRV 1178
               +E  IL       +  N                 + + F  +P      +  GP   
Sbjct: 1972 VEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYET 2031

Query: 1179 KCQALNKWEPELPSCSRVCQPPPDV-LHAERTQRDKDNFSPGQEVFYSCE-----PGYDL 1232
                      ELPS          V  H++ +Q         Q++ YS +      G+DL
Sbjct: 2032 SRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLRGFDL 2091

Query: 1233 RGAASMRCTPQ------GDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVNLQLGAKVD 1283
                    TP        D  P     E++ C D   F   ++ G         +G  V 
Sbjct: 2092 SELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRG-----AGYNVGQSVT 2146

Query: 1284 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG 1343
            F C  G+QL G     C   G    W+  +P CE + C       NG     P    P+ 
Sbjct: 2147 FECLPGYQLTGHPVLTCQ-HGTNRNWDHPLPKCE-VPCGGNITSSNGT-VYSPGFPSPYS 2203

Query: 1344 KAVN--YTCDPHPDRGTSFDLIGESTIRCTSDPQGN--GVWSSP---APRCGILGHCQAP 1396
             + +  +        G   +L    T     +P G+   +W  P   APR G+     A 
Sbjct: 2204 SSQDCVWLITVPIGHGVRLNLSLLQT-----EPSGDFITIWDGPQQTAPRLGVFTRSMAK 2258

Query: 1397 DHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKT 1456
                    KT  ++S+  +   LK+  R    G  F+I        + P   C       
Sbjct: 2259 --------KTVQSSSNQVL---LKFH-RDAATGGIFAIAFS-----AYPLTKC------- 2294

Query: 1457 PPDPVNGMVHVITD---IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ- 1512
            PP  +     V+T+     +G  + Y C  G  L+G+    C L G    +   PPIC+ 
Sbjct: 2295 PPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKL-GTYLQFEGPPPICEV 2353

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYR-CNLGSRGRKVFELVGEPSIYCTSND-D 1570
              P     T + G  +S +    + GS   ++ C+   R    + +      + +    D
Sbjct: 2354 HCPTNELLTDSTGVILSQS----YPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYD 2409

Query: 1571 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
            +  I+ GP+ Q  +    +       I+ S + S++                   R    
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYL------------------RWSSD 2451

Query: 1631 QALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1690
             A N+   ++   +  C  P   LHG      Q +  PG  + + C  GY L G +   C
Sbjct: 2452 HAYNRKGFKIRYSAPYCSLPRAPLHGFILG--QTSTQPGGSIHFGCNAGYRLVGHSMAIC 2509

Query: 1691 T--PQGD--WSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSS 1746
            T  PQG   WS   P C   SC   L + P   ++F     +G K  + C EG+ L+  +
Sbjct: 2510 TRHPQGYHLWSEAIPLCQALSCG--LPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGA 2567

Query: 1747 --VSHCVLVGMRSLWNNS--VPVCEHIFCPNPPAIL--NGRHTGTPSGDIPYGKEISYTC 1800
               + C+  G   LW+N    P C  + CP+  +I   +GR          +  ++   C
Sbjct: 2568 EATAECLDTG---LWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLIC 2624

Query: 1801 DPHPDRGMTFNLIGESTIRCTSDPHGNGVWS--SPAPRCELSVRAGHCKTPEQFPFASPT 1858
            DP       +   G+  IRC +    NG WS     P C + +  G    P        T
Sbjct: 2625 DPG------YYYTGQRVIRCQA----NGKWSLGDSTPTCRI-ISCGELPIPPN-GHRIGT 2672

Query: 1859 IPINDFEFPVGTSLNYECRPGYFGKMFSI-SCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1917
            + +       G +  + C  GY      +  C+ N +WS  E  C    CG P    NG 
Sbjct: 2673 LSV------YGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNG- 2725

Query: 1918 VHINTDT-QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC----EPP 1972
             HIN +   +  +V Y CN GFRLIG     C    +   W  K P C ++SC     PP
Sbjct: 2726 -HINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHH---WSGKTPFCVLVSCGHPGSPP 2781

Query: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032
             +  +GD Y+        G VV Y C     G++   LVG  +  C       G W+   
Sbjct: 2782 HSQMSGDSYTV-------GAVVRYSCI----GKRT--LVGNSTRMCGLD----GHWTGSL 2824

Query: 2033 PRCISTNK--CTAPEVE-NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 2089
            P C  T+   C  P +  + IR+  +   F    ++RF C+ G V+ GS    CQ NG W
Sbjct: 2825 PHCSGTSVGVCGDPGIPAHGIRLGDS---FDPGTVMRFSCEAGHVLRGSSERTCQANGSW 2881

Query: 2090 GPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD 2148
                P C  + C  P    +     S    FS    + Y C   Y   G  S HC+  G 
Sbjct: 2882 SGSQPECGVISCGNPGTPSNARVVFSDGLVFS--SSIVYECREGYYATGLLSRHCSVNGT 2939

Query: 2149 WSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 2208
            W+   P C V +C D    +P   + L  + +    V++ C  G+ ++    S  VL+  
Sbjct: 2940 WTGSDPECLVINCGD--PGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVS--VLSCT 2995

Query: 2209 K-ALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 2267
            K   WN + PVC+ + C  PP I NG+  G+   D  +G  ++YAC           L G
Sbjct: 2996 KDRTWNGTKPVCKALMCKPPPLIPNGKVVGS---DFMWGSSVTYAC-----------LEG 3041

Query: 2268 -ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYI 2326
             + S+      +GNG W+   P+C    P  C  P     G       S      ++S+ 
Sbjct: 3042 YQLSLPAVFTCEGNGSWTGELPQC---FPVFCGDPGVPSRGRREDRGFSYR---SSVSFS 3095

Query: 2327 CDPGYLLVGKGFIFCTDQGIWSQLDHYCKE---VNCSFP-LFMNGISKELEMKKVYHYGD 2382
            C P  +LVG    FC   G WS     C +     C+ P +   GI       + Y  G 
Sbjct: 3096 CHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNN---SQGYQVGS 3152

Query: 2383 YVTLKCEDGYTLEGSPWSQCQADDRWD--PP 2411
             V  +C+ GY L+GS    C  +  W   PP
Sbjct: 3153 TVLFRCQKGYLLQGSTTRTCLPNLTWSGTPP 3183



 Score =  278 bits (712), Expect = 4e-74
 Identities = 319/1227 (25%), Positives = 455/1227 (37%), Gaps = 231/1227 (18%)

Query: 102  KSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC 161
            + C +P    NG+V    G   G  + + C  GY+L G    TC   G    WD+  P C
Sbjct: 2121 QECPDPEPFANGIVRGA-GYNVGQSVTFECLPGYQLTGHPVLTCQ-HGTNRNWDHPLPKC 2178

Query: 162  DRIPCGLPPTITNGDFISTNRENFHYGS---VVTYRCNPGSGGRKVFELVG-EPSIYCTS 217
            + +PCG   T +NG   S    + +  S   V       G G R    L+  EPS     
Sbjct: 2179 E-VPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPS----- 2232

Query: 218  NDDQVGIWSGP---APQCII---------------------------------------P 235
              D + IW GP   AP+  +                                        
Sbjct: 2233 -GDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPL 2291

Query: 236  NKCTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ--ALNKWEPELPS 292
             KC PP +  N  +V++N   F++ ++V +RC PGF + G   + C+     ++E   P 
Sbjct: 2292 TKCPPPTILPNAEVVTENEE-FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPI 2350

Query: 293  CSRVCQPPPDVLHAERTQRDKDNFSPGQ-EVFYSC------EPGYDLR------------ 333
            C   C  P + L  + T        PG    F +C      EP Y++             
Sbjct: 2351 CEVHC--PTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQY 2408

Query: 334  ----------GAASMRCTPQGDWSP------------------------------AAPTC 353
                      G + +     G++S                               +AP C
Sbjct: 2409 DEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC 2468

Query: 354  EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSS 412
             +          L+G +L   + Q G  + F C+ G++L G S + C        LW+ +
Sbjct: 2469 SLPRAP------LHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEA 2522

Query: 413  VPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTS 472
            +P+C+ + C  P    NG   GK   V   G    Y+C      G       E+T  C  
Sbjct: 2523 IPLCQALSCGLPEAPKNGMVFGKEYTV---GTKAMYSCS----EGYHLQAGAEATAECLD 2575

Query: 473  DPQGNGVWSSP--APRCGILGHCQAPDHFLFAKLKTQTNA---SDFPIGTSLKYECRPEY 527
                 G+WS+    P+C  +     PD    +    +      + +     L   C P Y
Sbjct: 2576 ----TGLWSNRNVPPQCVPV---TCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGY 2628

Query: 528  Y--GRPFSITCLDNLVWS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQV-GSRINYSCT 582
            Y  G+   I C  N  WS       C+  SC   P P NG  H I  + V G+   +SC 
Sbjct: 2629 YYTGQRV-IRCQANGKWSLGDSTPTCRIISCGELPIPPNG--HRIGTLSVYGATAIFSCN 2685

Query: 583  TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVT 642
            +G+ L+G    EC+ +G    WS     C    CG P  I NG     N EN+ Y   V 
Sbjct: 2686 SGYTLVGSRVRECMANGL---WSGSEVRCLAGHCGTPEPIVNGHI---NGENYSYRGSVV 2739

Query: 643  YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 702
            Y+CN G      F L+G     C  +      WSG  P C++ +   P +  +  +  D+
Sbjct: 2740 YQCNAG------FRLIGMSVRICQQDHH----WSGKTPFCVLVSCGHPGSPPHSQMSGDS 2789

Query: 703  RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR----VCQPPPDVLHAER 758
               +++  VV + C     + G     C     W   LP CS     VC  P    H  R
Sbjct: 2790 ---YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIR 2846

Query: 759  TQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNG 818
                 D+F PG  + +SCE G+ LRG++   C   G WS + P C V SC +  G   N 
Sbjct: 2847 LG---DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGN-PGTPSNA 2902

Query: 819  RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIP 878
            RV+F   L   + + + C EG+   G  + +C + G    W  S P C  I C  P +  
Sbjct: 2903 RVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG---TWTGSDPECLVINCGDPGIPA 2959

Query: 879  NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCG 938
            NG   G     F + KTV Y C P    G   +    S + CT D      W+   P C 
Sbjct: 2960 NGLRLGND---FRYNKTVTYQCVP----GYMMESHRVSVLSCTKD----RTWNGTKPVCK 3008

Query: 939  ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKD 997
             L  C+ P      K+      SDF  G+S+ Y C   Y    P   TC  N  W+    
Sbjct: 3009 AL-MCKPPPLIPNGKVV----GSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP 3063

Query: 998  VCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTK 1057
             C    C  P  P  G           S +++SC     L+G     C   G    WS  
Sbjct: 3064 QCFPVFCGDPGVPSRGR-REDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGT---WSGT 3119

Query: 1058 PPIC---QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIY 1114
             P C       C  P     G  I  N + +  GS V +RC  G      + L G  +  
Sbjct: 3120 QPSCIDPTLTTCADPGVPQFG--IQNNSQGYQVGSTVLFRCQKG------YLLQGSTTRT 3171

Query: 1115 CTSNDDQVGIWSGPAPQCIIPNKC----TPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 1170
            C  N      WSG  P C +P+ C    TP +   G L      L S+   + + CQ GF
Sbjct: 3172 CLPN----LTWSGTPPDC-VPHHCRQPETPTHANVGAL-----DLPSMGYTLIYSCQEGF 3221

Query: 1171 VMKGPRRVK-CQALNKWEPELPSCSRV 1196
             +KG    + C+A   W  + P C  V
Sbjct: 3222 SLKGGSEHRTCKADGSWTGKPPICLEV 3248



 Score =  278 bits (711), Expect = 5e-74
 Identities = 407/1688 (24%), Positives = 599/1688 (35%), Gaps = 301/1688 (17%)

Query: 95   AKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVI 153
            A  R     C + P+P  G   +      G+ +++ C  GY L GS    C+ + G    
Sbjct: 1726 AVPRTSATQCSSVPEPRYGK-RLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQ 1784

Query: 154  WDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSV-VTYRCNPGSGGRKVFELVGEPS 212
            W+   P C  +PCG   T   G  +S      +  S+   ++     G     ++V   S
Sbjct: 1785 WNVSAPTCV-VPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVV---S 1840

Query: 213  IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVM 272
                 N D + ++ G      +    +   V   +L S +  L+     + F        
Sbjct: 1841 FVTEQNWDSLEVFDGADNTVTMLGSFSGTTVP-ALLNSTSNQLY-----LHFYSDISVSA 1894

Query: 273  KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 332
             G        L      L SC     P   V   ER       +     V + CEPGY L
Sbjct: 1895 AGFH------LEYKTVGLSSCPEPAVPSNGVKTGER-------YLVNDVVSFQCEPGYAL 1941

Query: 333  RGAASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVD 383
            +G A + C P     W+   P C +  C   + + + G +L       +P N+    K+ 
Sbjct: 1942 QGHAHISCMPGTVRRWNYPPPLC-IAQCGGTVEE-MEGVILSPGFPGNYPSNMDCSWKIA 1999

Query: 384  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPN---GRHTGKPLEVF 440
                 G             A ++ L  S+ P  + I   + P   +   GR +G  L   
Sbjct: 2000 LPVGFG-------------AHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSS 2046

Query: 441  PFGKTVNYTCDPHPDRGTS-----------------------FDLIGESTIRCTSDPQGN 477
                +   T   H D   +                       FDL        T     +
Sbjct: 2047 LLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLRGFDLSELERTNSTPPVAAS 2106

Query: 478  GVWS-SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSI 534
             VW   P      L  C  P+ F    ++     + + +G S+ +EC P Y   G P  +
Sbjct: 2107 YVWDLDPGCEAYELQECPDPEPFANGIVR----GAGYNVGQSVTFECLPGYQLTGHPV-L 2161

Query: 535  TCL--DNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSS 592
            TC    N  W  P   C+   C       NG V+       G    YS          SS
Sbjct: 2162 TCQHGTNRNWDHPLPKCE-VPCGGNITSSNGTVY-----SPGFPSPYS----------SS 2205

Query: 593  AECILSGNAAHWSTKPPICQ--RIPCGLPPTIANGDFIST---NRENFHYGSVVTYRCNP 647
             +C+       W    PI    R+   L  T  +GDFI+     ++      V T     
Sbjct: 2206 QDCV-------WLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFT----- 2253

Query: 648  GSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-ENGILVSDNRSLF 706
             S  +K  +      +     D   G     A       KC PP +  N  +V++N   F
Sbjct: 2254 RSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEE-F 2312

Query: 707  SLNEVVEFRCQPGFVMKGPRRVKCQ--ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKD 764
            ++ ++V +RC PGF + G   + C+     ++E   P C   C  P + L  + T     
Sbjct: 2313 NIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHC--PTNELLTDSTGVILS 2370

Query: 765  NFSPGQ-EVFYSC------EPGYDL----------------------RGAASMRCTPQGD 795
               PG    F +C      EP Y++                       G + +     G+
Sbjct: 2371 QSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGN 2430

Query: 796  WSP------------------------------AAPTCEVKSCDDFMGQLLNGRVLFPVN 825
            +S                               +AP C +          L+G +L   +
Sbjct: 2431 YSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAP------LHGFILGQTS 2484

Query: 826  LQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
             Q G  + F C+ G++L G S + C        LW+ ++P+C+ + C  P    NG   G
Sbjct: 2485 TQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFG 2544

Query: 885  KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS--SPAPRCGILGH 942
            K   V   G    Y+C      G       E+T  C       G+WS  +  P+C  +  
Sbjct: 2545 KEYTV---GTKAMYSC----SEGYHLQAGAEATAECLD----TGLWSNRNVPPQCVPV-- 2591

Query: 943  CQAPDHFLFAKLKTQTN------ASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWS- 993
               PD    + +  +         + +     L   C P YY  G+   I C  N  WS 
Sbjct: 2592 -TCPD---VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRV-IRCQANGKWSL 2646

Query: 994  -SPKDVCKRKSCKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECILSGNA 1051
                  C+  SC   P P NG  H I  + V G+   +SC +G+ L+G    EC+ +G  
Sbjct: 2647 GDSTPTCRIISCGELPIPPNG--HRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANG-- 2702

Query: 1052 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 1111
              WS     C    CG P  I NG     N EN+ Y   V Y+CN G      F L+G  
Sbjct: 2703 -LWSGSEVRCLAGHCGTPEPIVNGHI---NGENYSYRGSVVYQCNAG------FRLIGMS 2752

Query: 1112 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171
               C  +      WSG  P C++ +   P +  +  +  D+   +++  VV + C     
Sbjct: 2753 VRICQQDHH----WSGKTPFCVLVSCGHPGSPPHSQMSGDS---YTVGAVVRYSCIGKRT 2805

Query: 1172 MKGPRRVKCQALNKWEPELPSCS----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCE 1227
            + G     C     W   LP CS     VC  P    H  R     D+F PG  + +SCE
Sbjct: 2806 LVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRL---GDSFDPGTVMRFSCE 2862

Query: 1228 PGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCD 1287
             G+ LRG++   C   G WS + P C V SC +  G   N RV+F   L   + + + C 
Sbjct: 2863 AGHVLRGSSERTCQANGSWSGSQPECGVISCGN-PGTPSNARVVFSDGLVFSSSIVYECR 2921

Query: 1288 EGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVN 1347
            EG+   G  + +C + G    W  S P C  I C  P +  NG   G     F + K V 
Sbjct: 2922 EGYYATGLLSRHCSVNG---TWTGSDPECLVINCGDPGIPANGLRLGND---FRYNKTVT 2975

Query: 1348 YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQ 1407
            Y C P    G   +    S + CT D      W+   P C  L  C+ P      K+   
Sbjct: 2976 YQCVP----GYMMESHRVSVLSCTKD----RTWNGTKPVCKAL-MCKPPPLIPNGKVV-- 3024

Query: 1408 TNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVH 1466
               SDF  G+S+ Y C   Y    P   TC  N  W+     C    C  P  P  G   
Sbjct: 3025 --GSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGR-R 3081

Query: 1467 VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC---QRIPCGLPPTIA 1523
                    S +++SC     L+G     C   G    WS   P C       C  P    
Sbjct: 3082 EDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGT---WSGTQPSCIDPTLTTCADPGVPQ 3138

Query: 1524 NGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1583
             G  I  N + +  GS V +RC  G      + L G  +  C  N      WSG  P C 
Sbjct: 3139 FG--IQNNSQGYQVGSTVLFRCQKG------YLLQGSTTRTCLPN----LTWSGTPPDC- 3185

Query: 1584 IPNKC----TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQALNKWEP 1638
            +P+ C    TP +   G L      L S+   + + CQ GF +KG    + C+A   W  
Sbjct: 3186 VPHHCRQPETPTHANVGAL-----DLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTG 3240

Query: 1639 ELPSCSRV 1646
            + P C  V
Sbjct: 3241 KPPICLEV 3248



 Score =  268 bits (685), Expect = 5e-71
 Identities = 285/1097 (25%), Positives = 418/1097 (38%), Gaps = 219/1097 (19%)

Query: 1452 KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC 1511
            + C  P    NG+V       VG  + + C  G++L GH    C   G   +W    P C
Sbjct: 2121 QECPDPEPFANGIVRG-AGYNVGQSVTFECLPGYQLTGHPVLTC-QHGTNRNWDHPLPKC 2178

Query: 1512 QRIPCGLPPTIANGDFISTNRENFHYGS-----VVTYRCNLGSRGRKVFELVGEPSIYCT 1566
            + +PCG   T +NG   S    + +  S     ++T     G R   +  L  EPS    
Sbjct: 2179 E-VPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVR-LNLSLLQTEPS---- 2232

Query: 1567 SNDDQVGIWSGP---APQCII--------------------------------------- 1584
               D + IW GP   AP+  +                                       
Sbjct: 2233 --GDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYP 2290

Query: 1585 PNKCTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ--ALNKWEPELP 1641
              KC PP +  N  +V++N   F++ ++V +RC PGF + G   + C+     ++E   P
Sbjct: 2291 LTKCPPPTILPNAEVVTENEE-FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPP 2349

Query: 1642 SCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSC------EPGYDLR------------ 1683
             C   C P  E+L          ++      F +C      EP Y++             
Sbjct: 2350 ICEVHC-PTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQY 2408

Query: 1684 ----------GAASLHCTPQGDWSPEAPRCAVKSCDDF---------------------- 1711
                      G + L     G++S  AP     S +                        
Sbjct: 2409 DEFEIFDGPSGQSPLLKALSGNYS--APLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAP 2466

Query: 1712 ---LGQLP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMR-SLWNNSVPVC 1766
               L + P HG +L   + Q G  + F C+ G+RL G S++ C        LW+ ++P+C
Sbjct: 2467 YCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC 2526

Query: 1767 EHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG 1826
            + + C  P A  NG   G    +   G +  Y+C      G       E+T  C      
Sbjct: 2527 QALSCGLPEAPKNGMVFGK---EYTVGTKAMYSCS----EGYHLQAGAEATAECLD---- 2575

Query: 1827 NGVWSSP--APRC---------ELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYE 1875
             G+WS+    P+C          +SV  G  +             I + ++     L   
Sbjct: 2576 TGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRL------------IFETQYQFQAQLMLI 2623

Query: 1876 CRPGYF--GKMFSISCLENLVWSSVEDN--CRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1931
            C PGY+  G+   I C  N  WS  +    CR  SCG  P P NG   I T + +G+T  
Sbjct: 2624 CDPGYYYTGQRV-IRCQANGKWSLGDSTPTCRIISCGELPIPPNGH-RIGTLSVYGATAI 2681

Query: 1932 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNG 1991
            +SCN G+ L+GS    C+ +G    W      C    C  P  I NG     N +  + G
Sbjct: 2682 FSCNSGYTLVGSRVRECMANG---LWSGSEVRCLAGHCGTPEPIVNGHINGENYS--YRG 2736

Query: 1992 TVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIR 2051
            +VV YQC+ G      F L+G     C     Q   WS   P C+  + C  P      +
Sbjct: 2737 SVV-YQCNAG------FRLIGMSVRIC----QQDHHWSGKTPFCVLVS-CGHPGSPPHSQ 2784

Query: 2052 VPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR----VCQPPPEIL 2107
            + G+   +T+  ++R+ C     +VG+ T  C  +G W   LPHCS     VC  P    
Sbjct: 2785 MSGDS--YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPA 2842

Query: 2108 HGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQ 2167
            HG   +   D+F PG  + +SCE  + LRG++   C   G WS   P C V SC +  G 
Sbjct: 2843 HG---IRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGN-PGT 2898

Query: 2168 LPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNP 2227
              + RV+    L   + + + C EG+   G  + HC + G    W  S P C  I C +P
Sbjct: 2899 PSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGT---WTGSDPECLVINCGDP 2955

Query: 2228 PAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPA 2287
                NG   G    D  Y K ++Y C      G        S + CT D      W+   
Sbjct: 2956 GIPANGLRLGN---DFRYNKTVTYQCVP----GYMMESHRVSVLSCTKDR----TWNGTK 3004

Query: 2288 PRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIW 2347
            P C+  +   C  PP I NG  +G   S ++ G +++Y C  GY L       C   G W
Sbjct: 3005 PVCKALM---CKPPPLIPNGKVVG---SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSW 3058

Query: 2348 SQLDHYCKEVNCSFPLFMNGI-SKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD 2406
            +     C  V C  P    G+ S+     + + Y   V+  C     L GSP   CQ+D 
Sbjct: 3059 TGELPQCFPVFCGDP----GVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDG 3114

Query: 2407 RW--------DPPLAKC 2415
             W        DP L  C
Sbjct: 3115 TWSGTQPSCIDPTLTTC 3131



 Score =  258 bits (660), Expect = 4e-68
 Identities = 309/1238 (24%), Positives = 444/1238 (35%), Gaps = 216/1238 (17%)

Query: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQ--ALNKWEPELPSCSRVCQPPPDVLHAERTQRDK 1213
            +++ + V F C PG+ + G   + CQ      W+  LP C   C                
Sbjct: 2139 YNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCG--------------- 2183

Query: 1214 DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT----------CEVKSCDDFMG 1263
             N +      YS  PG+    ++S  C     W    P            + +   DF+ 
Sbjct: 2184 GNITSSNGTVYS--PGFPSPYSSSQDCV----WLITVPIGHGVRLNLSLLQTEPSGDFIT 2237

Query: 1264 QLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL--------AGMESLWNSSVPV 1315
                 +   P   +LG     +  +  Q   SS++  +L         G+ ++  S+ P+
Sbjct: 2238 IWDGPQQTAP---RLGVFTRSMAKKTVQ---SSSNQVLLKFHRDAATGGIFAIAFSAYPL 2291

Query: 1316 CEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQ 1375
             +   CP P ++PN     +  E F  G  V Y C P       F L+G   + C     
Sbjct: 2292 TK---CPPPTILPNAEVVTEN-EEFNIGDIVRYRCLP------GFTLVGNEILTCKLGTY 2341

Query: 1376 GNGVWSSPAPRCGILGHCQA---------------------------------PDH---- 1398
                +  P P C +  HC                                   PD+    
Sbjct: 2342 LQ--FEGPPPICEV--HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISL 2397

Query: 1399 ----FLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLV---WSSPKDVCKR 1451
                FL  K   +    D P G S   +     Y  P  +T   N V   WSS     ++
Sbjct: 2398 TVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRK 2457

Query: 1452 --------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH 1503
                      C  P  P++G +   T  Q G  I++ C  G+RL+GHS A C       H
Sbjct: 2458 GFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYH 2517

Query: 1504 -WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPS 1562
             WS   P+CQ + CGLP    NG       + +  G+   Y C+ G       +   E +
Sbjct: 2518 LWSEAIPLCQALSCGLPEAPKNGMVFG---KEYTVGTKAMYSCSEGYH----LQAGAEAT 2570

Query: 1563 IYCTSNDDQVGIWS--GPAPQCIIPNKC---TPPNVENGILVSDNRSLFSLNEVVEFRCQ 1617
              C       G+WS     PQC +P  C   +  +VE+G       + +     +   C 
Sbjct: 2571 AECL----DTGLWSNRNVPPQC-VPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICD 2625

Query: 1618 PGFVMKGPRRVKCQALNKWE--PELPSCSRVC---QPPPEILHGEHTPSHQDNFSPGQEV 1672
            PG+   G R ++CQA  KW      P+C  +     P P   H   T S       G   
Sbjct: 2626 PGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVY-----GATA 2680

Query: 1673 FYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLG 1729
             +SC  GY L G+    C   G WS    RC    C   +  +    +G      N    
Sbjct: 2681 IFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGE-----NYSYR 2735

Query: 1730 AKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD 1789
              V + C+ GFRL G SV  C        W+   P C  + C +P    +  H+      
Sbjct: 2736 GSVVYQCNAGFRLIGMSVRIC---QQDHHWSGKTPFCVLVSCGHPG---SPPHSQMSGDS 2789

Query: 1790 IPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849
               G  + Y+C           L+G ST  C  D H    W+   P C      G C  P
Sbjct: 2790 YTVGAVVRYSCIGKR------TLVGNSTRMCGLDGH----WTGSLPHCS-GTSVGVCGDP 2838

Query: 1850 EQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCG 1908
                  +  I + D  F  GT + + C  G+  +  S  +C  N  WS  +  C   SCG
Sbjct: 2839 ---GIPAHGIRLGD-SFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCG 2894

Query: 1909 PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIIS 1968
             P  P N  V  +    F S++ Y C EG+   G  S  C V+G   TW    P C +I+
Sbjct: 2895 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG---TWTGSDPECLVIN 2951

Query: 1969 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER-SIYCTSKDDQVGV 2027
            C  P   +NG    N+   F     VTYQC  G      + +   R S+   +KD     
Sbjct: 2952 CGDPGIPANGLRLGND---FRYNKTVTYQCVPG------YMMESHRVSVLSCTKD---RT 2999

Query: 2028 WSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNG 2087
            W+   P C     C  P +    +V G  S F     + + C  G+ +       C+ NG
Sbjct: 3000 WNGTKPVC-KALMCKPPPLIPNGKVVG--SDFMWGSSVTYACLEGYQLSLPAVFTCEGNG 3056

Query: 2088 RWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQ 2146
             W  +LP C  V C  P     G         FS    V +SC P   L G+    C   
Sbjct: 3057 SWTGELPQCFPVFCGDPGVPSRGRR---EDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSD 3113

Query: 2147 GDWSPEAPRC---TVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 2203
            G WS   P C   T+ +C D  G    G        Q+G+ V F C +G+ L+G +   C
Sbjct: 3114 GTWSGTQPSCIDPTLTTCAD-PGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTC 3172

Query: 2204 VLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIP-YGKEISYACDTHPDRGMT 2262
            +       W+ + P C    C  P       H      D+P  G  + Y+C         
Sbjct: 3173 L---PNLTWSGTPPDCVPHHCRQPE---TPTHANVGALDLPSMGYTLIYSCQE------G 3220

Query: 2263 FNLIGESSIR-CTSDPQGNGVWSSPAPRCELSVPAACP 2299
            F+L G S  R C +D    G W+   P C    P+  P
Sbjct: 3221 FSLKGGSEHRTCKAD----GSWTGKPPICLEVRPSGRP 3254



 Score =  250 bits (638), Expect = 1e-65
 Identities = 258/980 (26%), Positives = 366/980 (37%), Gaps = 135/980 (13%)

Query: 13   GPPAPGLPFCCGGSLLA----VVVLLALPVAWGQCNAPEWLPFARPT---NLTDEFEFPI 65
            GPP      C    LL     V++  + P ++ Q     WL    P    +LT E+    
Sbjct: 2346 GPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSE 2405

Query: 66   GTYLNYECRPGYSGR-------------PFSIICLKNSVWT-----------GAKDRCRR 101
              Y  +E   G SG+             P  +    NSV+            G K R   
Sbjct: 2406 KQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465

Query: 102  KSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTV-IWDNETPI 160
              C  P  P++G +      Q G  I + C  GYRL+G S A C        +W    P+
Sbjct: 2466 PYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPL 2525

Query: 161  CDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 220
            C  + CGLP    NG       + +  G+   Y C+ G      + L  +     T+   
Sbjct: 2526 CQALSCGLPEAPKNGMVFG---KEYTVGTKAMYSCSEG------YHL--QAGAEATAECL 2574

Query: 221  QVGIWS--GPAPQCIIPNKC---TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275
              G+WS     PQC +P  C   +  +VE+G       + +     +   C PG+   G 
Sbjct: 2575 DTGLWSNRNVPPQC-VPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQ 2633

Query: 276  RRVKCQALNKWE--PELPSCSRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 330
            R ++CQA  KW      P+C  +     P P   H   T         G    +SC  GY
Sbjct: 2634 RVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLS-----VYGATAIFSCNSGY 2688

Query: 331  DLRGAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCD 387
             L G+    C   G WS +   C    C   +  +   +NG      N      V + C+
Sbjct: 2689 TLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGE-----NYSYRGSVVYQCN 2743

Query: 388  EGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVN 447
             GF+L G S   C     +  W+   P C  + C  P   P+ + +G   + +  G  V 
Sbjct: 2744 AGFRLIGMSVRIC---QQDHHWSGKTPFCVLVSCGHPGSPPHSQMSG---DSYTVGAVVR 2797

Query: 448  YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFA 502
            Y+C           L+G ST  C  D    G W+   P C     G+ G    P H +  
Sbjct: 2798 YSCI------GKRTLVGNSTRMCGLD----GHWTGSLPHCSGTSVGVCGDPGIPAHGI-- 2845

Query: 503  KLKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPV 561
                      F  GT +++ C   +  R  S  TC  N  WS  +  C   SC  P  P 
Sbjct: 2846 -----RLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPS 2900

Query: 562  NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPT 621
            N  V     +   S I Y C  G+   G  S  C ++G    W+   P C  I CG P  
Sbjct: 2901 NARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGT---WTGSDPECLVINCGDPGI 2957

Query: 622  IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
             ANG  +     +F Y   VTY+C PG     + E      + CT +      W+G  P 
Sbjct: 2958 PANGLRLG---NDFRYNKTVTYQCVPG----YMMESHRVSVLSCTKD----RTWNGTKPV 3006

Query: 682  CIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELP 741
            C       PP + NG +V  +   F     V + C  G+ +  P    C+    W  ELP
Sbjct: 3007 CKALMCKPPPLIPNGKVVGSD---FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP 3063

Query: 742  SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAP 801
             C  V    P V    R +R+   FS    V +SC P   L G+    C   G WS   P
Sbjct: 3064 QCFPVFCGDPGV--PSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP 3121

Query: 802  TC---EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
            +C    + +C D  G    G        Q+G+ V F C +G+ L+GS+   C+       
Sbjct: 3122 SCIDPTLTTCAD-PGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCL---PNLT 3177

Query: 859  WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
            W+ + P C    C  P   P   + G  L++   G T+ Y+C         F L G S  
Sbjct: 3178 WSGTPPDCVPHHCRQPET-PTHANVG-ALDLPSMGYTLIYSCQ------EGFSLKGGSEH 3229

Query: 919  R-CTSDPQGNGVWSSPAPRC 937
            R C +D    G W+   P C
Sbjct: 3230 RTCKAD----GSWTGKPPIC 3245



 Score =  134 bits (337), Expect = 1e-30
 Identities = 523/2429 (21%), Positives = 798/2429 (32%), Gaps = 542/2429 (22%)

Query: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVK 356
            PD    ER +R   +F  G  V ++C  GYDL+G+  + C    D    WS   P C  +
Sbjct: 344  PDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAR 403

Query: 357  SCD-------------DFMGQLLNG-------RVLFPVNLQLGAKVDFVCDEGFQ----- 391
             CD             +F  Q  N          L P  +   A  +F  + G+      
Sbjct: 404  MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVG 463

Query: 392  --------------LKGSSASYCVLAGMESLW--------------NSSVPVCEQIFCPS 423
                          L G+S    +++    +W               +S    EQ  C  
Sbjct: 464  DGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGD 523

Query: 424  PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSP 483
            P +   GR  G     F  G T+ + C P      +F+L+G+  I C    Q N  WS+ 
Sbjct: 524  PGIPAYGRREGSR---FHHGDTLKFECQP------AFELVGQKAITC----QKNNQWSAK 570

Query: 484  APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVW 542
             P C  +  C     F F        + ++P        C      RP S I    N + 
Sbjct: 571  KPGC--VFSC----FFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDID 624

Query: 543  SSPK-DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA 601
              P+ D    K   T   PV G     +  Q+ S I    ++GH  +     +   S   
Sbjct: 625  VEPQFDFLVIKDGATAEAPVLG---TFSGNQLPSSIT---SSGH--VARLEFQTDHSTGK 676

Query: 602  AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 661
              ++      +   C  P    NG       ++   GS +++ C+ G  G +     G  
Sbjct: 677  RGFNITFTTFRHNECPDPGVPVNGKRFG---DSLQLGSSISFLCDEGFLGTQ-----GSE 728

Query: 662  SIYCTSNDDQVGIWSGPAPQCIIP--NKCTPPNVENGILVSDN-----RSLFSLNEVVEF 714
            +I C   +  V +W+    +C  P     T P   +G ++S       +   S   V+E 
Sbjct: 729  TITCVLKEGSV-VWNSAVLRCEAPCGGHLTSP---SGTILSPGWPGFYKDALSCAWVIE- 783

Query: 715  RCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 774
              QPG+ +K         +N    E+        P   V H  +  +   + S    + +
Sbjct: 784  -AQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLF 842

Query: 775  SCEP-----GYDLRGAASMRCTPQGD--WSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQ 827
            S +      G+ LR       T Q D    P  P    +  +DF                
Sbjct: 843  STDKSHSDIGFQLRYET---ITLQSDHCLDPGIPVNGQRHGNDF---------------Y 884

Query: 828  LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE------------QIFCPS-P 874
            +GA V F CD G+ L       C        W+ ++P CE             I  P  P
Sbjct: 885  VGALVTFSCDSGYTLSDGEPLEC---EPNFQWSRALPSCEALCGGFIQGSSGTILSPGFP 941

Query: 875  PVIPNGRHTGKPLEVFPFGKTVNYTCDP-HPDRGTSFDLIGESTIRCTSDPQGNGVWSSP 933
               PN  +    +E    GK V +T    H + G  + LI E+        Q  G    P
Sbjct: 942  DFYPNNLNCTWIIET-SHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGS-RLP 999

Query: 934  AP-RCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW 992
            AP   G+ G+  A   F+          SDF    S+ YE         F+IT       
Sbjct: 1000 APISAGLYGNFTAQVRFI----------SDF----SMSYE--------GFNIT------- 1030

Query: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052
             S  D+   + C+ P  P    +       VG  + +SC  G+RL G +   C L G   
Sbjct: 1031 FSEYDL---EPCEEPEVPAYS-IRKGLQFGVGDTLTFSCFPGYRLEGTARITC-LGGRRR 1085

Query: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTN---RENFHYGSVVTYRCNPGSG---GRKVFE 1106
             WS+  P C    CG   T   G  +S N     N ++  + + +  PG G     + FE
Sbjct: 1086 LWSSPLPRCV-AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFE 1144

Query: 1107 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 1166
            L         S  D + ++ G      +    +   +    L S + SL+          
Sbjct: 1145 L---------SEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWL--------- 1186

Query: 1167 QPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 1226
               F+       K   L+    EL  C       P          D+ +F+ G  V +SC
Sbjct: 1187 --DFITDAENTSKGFELHFSSFELIKCE-----DPGTPKFGYKVHDEGHFA-GSSVSFSC 1238

Query: 1227 EPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP----------- 1273
            +PGY LRG+  + C    +  W    PTC V  C   +   ++G+VL P           
Sbjct: 1239 DPGYSLRGSEELLCLSGERRTWDRPLPTC-VAECGGTVRGEVSGQVLSPGYPAPYEHNLN 1297

Query: 1274 ----VNLQLGAKV-------------------DFVCDEGFQLKGSSASYCVLAGMESLWN 1310
                +  + G  +                   D   + G  LK  S    +   + S +N
Sbjct: 1298 CIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGP-ALPKDLHSTFN 1356

Query: 1311 SSV------------------PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDP 1352
            S V                   V     C  P +  NG  +G   E    G +  + CDP
Sbjct: 1357 SVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEA---GDSTVFQCDP 1413

Query: 1353 HPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD 1412
                   + L G + I C    +    W    P C  +  C          + +      
Sbjct: 1414 ------GYALQGSAEISCVK-IENRFFWQPSPPTC--IAPCGGDLTGPSGVILSPNYPEP 1464

Query: 1413 FPIGTSL--KYECRPEYYGRPFSITCLDNLVWSSP-KDVCKRKSCKTPPDPVNGMVHVIT 1469
            +P G     K    P+Y      I  + N+    P  D       +    P+ G  +   
Sbjct: 1465 YPPGKECDWKVTVSPDYV-----IALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFY--- 1516

Query: 1470 DIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIS 1529
              Q+  RI  S +    L   S A    +G    ++  P    R  C  P +I NG  + 
Sbjct: 1517 GSQLPGRIE-SSSNSLFLAFRSDASVSNAGFVIDYTENP----RESCFDPGSIKNGTRVG 1571

Query: 1530 TNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 1589
            +   +   GS VTY C+ G      +E+ G  ++ C    D   +W+ P P C  P  C 
Sbjct: 1572 S---DLKLGSSVTYYCHGG------YEVEGTSTLSCILGPDGKPVWNNPRPVCTAP--CG 1620

Query: 1590 PPNV-ENGILVSDN--RSLFSLNEVVEFRCQP-GFVMKGPRRVKCQALNKWEPELPSCSR 1645
               V  +G+++S N  ++  S    + F   P  +V+ G       ALN    E+     
Sbjct: 1621 GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALND-VVEVHDGHS 1679

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAV 1705
                    L G HT       +  Q +      G  L  A   H   Q       PR + 
Sbjct: 1680 QHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKG--LAPARGFHFVYQA-----VPRTSA 1732

Query: 1706 KSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLV-GMRSLWNNSVP 1764
              C   + +  +G+ L   +  +GA V F C+ G+ L+GS    C+ V G  + WN S P
Sbjct: 1733 TQCSS-VPEPRYGKRL-GSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAP 1790

Query: 1765 VC------------EHIFCPN-PPAILNGRH----TGTPSGDIPYGKEISYTCDPHPD-- 1805
             C              I  P  P   LN  +       P G     + +S+  + + D  
Sbjct: 1791 TCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSL 1850

Query: 1806 -----RGMTFNLIGE---STIRCTSDPHGNGVWSSPAPRCELSVRAGHC--KTPEQFPFA 1855
                    T  ++G    +T+    +   N ++        +S    H   KT       
Sbjct: 1851 EVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCP 1910

Query: 1856 SPTIPINDFE----FPVGTSLNYECRPGYFGKMFS-ISCLENLV--WSSVEDNCRRKSCG 1908
             P +P N  +    + V   ++++C PGY  +  + ISC+   V  W+     C  + CG
Sbjct: 1911 EPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQ-CG 1969

Query: 1909 PPPEPFNGMV-----------------HINTDTQFGSTV---NYSC---NEGFRLIGSPS 1945
               E   G++                  I     FG+ +   N+S    ++   +   P 
Sbjct: 1970 GTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPY 2029

Query: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSF---HNGTVVTYQCHTGP 2002
             T  + G    +        ++S     T+     +S NR  F   +     ++Q  +  
Sbjct: 2030 ETSRMMGR---FSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFL 2086

Query: 2003 DGEQLFELVGERSIYCTSKDDQVGVWS-SPPPRCISTNKCTAPE--VENAIRVPGNRSFF 2059
             G  L EL    S   T       VW   P        +C  PE      +R  G    +
Sbjct: 2087 RGFDLSELERTNS---TPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAG----Y 2139

Query: 2060 TLTEIIRFRCQPGFVMVGSHTVQCQ--TNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQD 2117
             + + + F C PG+ + G   + CQ  TN  W   LP C   C        G  T S+  
Sbjct: 2140 NVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC-------GGNITSSNGT 2192

Query: 2118 NFSPGQEVFYSCEP----------SYDLR-GAASLHCTPQGDW-------SPEAPRCTV- 2158
             +SPG    YS              + +R   + L   P GD+          APR  V 
Sbjct: 2193 VYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVF 2252

Query: 2159 -KSCDDFLGQLPHGRVLL-------------------PL-------------------NL 2179
             +S      Q    +VLL                   PL                     
Sbjct: 2253 TRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEF 2312

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
             +G  V + C  GF L G     C L G    +    P+CE + CP    + +   TG  
Sbjct: 2313 NIGDIVRYRCLPGFTLVGNEILTCKL-GTYLQFEGPPPICE-VHCPTNELLTDS--TGVI 2368

Query: 2240 F-----GDIPYGKEISYACDTHPDRGMTFN----------------------------LI 2266
                  G  P  +  S+     PD  ++                              L 
Sbjct: 2369 LSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALS 2428

Query: 2267 GESSIRCTSDPQGNGV---WSS-------------PAPRCELSVPAACPHPPKIQNGHYI 2310
            G  S         N V   WSS              AP C L         P+     +I
Sbjct: 2429 GNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSL---------PRAPLHGFI 2479

Query: 2311 GGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQG--IWSQLDHYCKEVNCSFPLFMN 2366
             G  S   PG +I + C+ GY LVG     CT   QG  +WS+    C+ ++C  P    
Sbjct: 2480 LGQTSTQ-PGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLP---E 2535

Query: 2367 GISKELEMKKVYHYGDYVTLKCEDGYTLE 2395
                 +   K Y  G      C +GY L+
Sbjct: 2536 APKNGMVFGKEYTVGTKAMYSCSEGYHLQ 2564



 Score =  122 bits (306), Expect = 4e-27
 Identities = 297/1426 (20%), Positives = 496/1426 (34%), Gaps = 286/1426 (20%)

Query: 100  RRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYR-LIGSSSATCIISGDTVIWDNET 158
            R   C +P  PVNG       +Q GS I + C +G+    GS + TC++   +V+W++  
Sbjct: 687  RHNECPDPGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745

Query: 159  PICDRIPCGLPPTITNGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYC 215
              C+  PCG   T  +G  +S     F+  ++         PG   +  F+       Y 
Sbjct: 746  LRCE-APCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYD 804

Query: 216  TSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275
            T        +S  AP   + +    P      L+S +  L+ L    +     GF ++  
Sbjct: 805  TLEVRDGRTYS--APLIGVYHGTQVPQ----FLISTSNYLYLLFSTDKSHSDIGFQLR-Y 857

Query: 276  RRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
              +  Q+ +  +P +P            ++ +R   D   F  G  V +SC+ GY L   
Sbjct: 858  ETITLQSDHCLDPGIP------------VNGQRHGND---FYVGALVTFSCDSGYTLSDG 902

Query: 336  ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------------- 373
              + C P   WS A P+CE   C  F+ Q  +G +L P                      
Sbjct: 903  EPLECEPNFQWSRALPSCEA-LCGGFI-QGSSGTILSPGFPDFYPNNLNCTWIIETSHGK 960

Query: 374  --------VNLQLGAKVDFVCDEGF------QLKGSSASYCVLAGMESLWNSSVPVCEQI 419
                     +L+ G     + + G       QL GS     + AG+   + + V      
Sbjct: 961  GVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDF 1020

Query: 420  F-----------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDL 462
                              C  P V       G     F  G T+ ++C P       + L
Sbjct: 1021 SMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQ---FGVGDTLTFSCFP------GYRL 1071

Query: 463  IGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNAS----DFPIGTS 518
             G + I C    +   +WSSP PRC  +  C            T T  +    +FP+  +
Sbjct: 1072 EGTARITCLGGRR--RLWSSPLPRC--VAEC--------GNSVTGTQGTLLSPNFPVNYN 1119

Query: 519  LKYECRPEYYGRPFSITCLDNLVWS-SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 577
              +EC      +P     L    +  S  DV K          + G+        +G  +
Sbjct: 1120 NNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFS--HSEMMGVTL 1177

Query: 578  NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHY 637
            N S ++   L   + AE    G   H+S+     + I C  P T   G     + E    
Sbjct: 1178 N-STSSSLWLDFITDAENTSKGFELHFSS----FELIKCEDPGTPKFG--YKVHDEGHFA 1230

Query: 638  GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGI 697
            GS V++ C+PG      + L G   + C S + +   W  P P C+     T     +G 
Sbjct: 1231 GSSVSFSCDPG------YSLRGSEELLCLSGERRT--WDRPLPTCVAECGGTVRGEVSGQ 1282

Query: 698  LVSDNRSL---FSLNEVVEFRCQPG------FVMKGPRRVKCQALNKWEPELPSCSRVCQ 748
            ++S         +LN +     + G      F++     V    L  W+  + S   + +
Sbjct: 1283 VLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVH-DVLRIWDGPVESGVLLKE 1341

Query: 749  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 808
                 L  +               F++ + G+ ++ + S   T      P  P    +S 
Sbjct: 1342 LSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVS---TATSCNDPGIPQNGSRSG 1398

Query: 809  DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 868
            D +               + G    F CD G+ L+GS+   CV       W  S P C  
Sbjct: 1399 DSW---------------EAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA 1443

Query: 869  IFCPSPPVIPNGRHTGKPL-EVFPFGKTVNYTCDPHPD-----------RGTSFDLIGES 916
              C      P+G        E +P GK  ++     PD               +D +   
Sbjct: 1444 P-CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIY 1502

Query: 917  TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPE 976
              R +  P     + S  P     G  ++  + LF   ++  + S+   G  + Y   P 
Sbjct: 1503 DGRDSLSPLIGSFYGSQLP-----GRIESSSNSLFLAFRSDASVSN--AGFVIDYTENP- 1554

Query: 977  YYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHR 1036
                                    R+SC  P    NG   V +D+++GS + Y C  G+ 
Sbjct: 1555 ------------------------RESCFDPGSIKNG-TRVGSDLKLGSSVTYYCHGGYE 1589

Query: 1037 LIGHSSAECILSGNAAH-WSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYR 1094
            + G S+  CIL  +    W+   P+C   PCG     ++G  +S N  +N+  G +  Y 
Sbjct: 1590 VEGTSTLSCILGPDGKPVWNNPRPVC-TAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYF 1648

Query: 1095 CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRS 1154
                    K + + G+ + + T+ +D V +  G +    + +        +G    ++  
Sbjct: 1649 VTV----PKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSL------SGSHTGESLP 1698

Query: 1155 LFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKD 1214
            L + N+V+      G           QA+ +      + +  C   P+  + +R   D  
Sbjct: 1699 LATSNQVLIKFSAKGLAPARGFHFVYQAVPR------TSATQCSSVPEPRYGKRLGSD-- 1750

Query: 1215 NFSPGQEVFYSCEPGYDLRGAASMRCTP----QGDWSPAAPTCEVK---SCDDFMGQLLN 1267
             FS G  V + C  GY L+G+  + C P       W+ +APTC V    +  +  G +L+
Sbjct: 1751 -FSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILS 1809

Query: 1268 --------------GRVLFPVNLQLGAK-VDFVCDEGFQ-------------LKGSSASY 1299
                           +++ P    +  + V FV ++ +              + GS +  
Sbjct: 1810 PGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGT 1869

Query: 1300 CVLAGMESLWN-------SSVPVCEQIF-----------CPSPPVIPNGRHTGKPLEVFP 1341
             V A + S  N       S + V    F           CP P V  NG  TG   E + 
Sbjct: 1870 TVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTG---ERYL 1926

Query: 1342 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 1387
                V++ C+P       + L G + I C   P     W+ P P C
Sbjct: 1927 VNDVVSFQCEP------GYALQGHAHISCM--PGTVRRWNYPPPLC 1964



 Score =  108 bits (269), Expect = 9e-23
 Identities = 307/1431 (21%), Positives = 476/1431 (33%), Gaps = 336/1431 (23%)

Query: 813  GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES--LWNSSVPVCE--- 867
            G+L NG +       LG KV + C+ GF L+G +   C  AG E+   W+  +P C    
Sbjct: 143  GRLPNG-IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCH-AGSENSATWDFPLPSCRADD 200

Query: 868  --------QIFCPSPPVIPNGRHTGKPLE---VFPFGKTVNYTCDPHPDRGTSFDLIGES 916
                    Q    S P  P+  H         +   G T+             F L    
Sbjct: 201  ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVF-------IDFQLEDGY 253

Query: 917  TIRCTSDPQGNGVW----SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 972
                 +  +G+ +W    S PAP               + +L   ++ +    G S +Y+
Sbjct: 254  DFLEVTGTEGSSLWFTGASLPAPVISSKN---------WLRLHFTSDGNHRQRGFSAQYQ 304

Query: 973  CRPEYYGRPFSITCLDNLVWSSPKDVCKR-------KSCKTPPDPVNGMVHVITDIQVGS 1025
             + +   +   +  + +   S    V  +         C  P  P  G   + +D ++GS
Sbjct: 305  VKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGK-RLGSDFRLGS 363

Query: 1026 RINYSCTTGHRLIGHSSAECI-LSGNAAHWSTKPPICQRIPC-----GLPPTIANGDFIS 1079
             + ++C  G+ L G     C+ +S   A WS   P+C+   C     G    I + +F  
Sbjct: 364  SVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPI 423

Query: 1080 TNRENFHYGSVVTYRCNP----------------------GSGGRK------VFELVGE- 1110
                N H   ++T   NP                      G GG+       ++ L G  
Sbjct: 424  QYDNNAHCVWIIT-ALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTS 482

Query: 1111 -PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN------GILVSDNR--SLFSLNEV 1161
             P +  ++N     ++        +  K +   +E       GI     R  S F   + 
Sbjct: 483  VPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDT 542

Query: 1162 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC----QPPPDVLHAERTQRDKDNF- 1216
            ++F CQP F + G + + CQ  N+W  + P C   C      P  V+ +     D  N  
Sbjct: 543  LKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHL 602

Query: 1217 --------SPGQEVFYS-----CEPGYDL-------RGAASMRCTPQGDWSPAA------ 1250
                     P   +  +      EP +D           A +  T  G+  P++      
Sbjct: 603  HCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGH 662

Query: 1251 ---------------------PTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEG 1289
                                  T     C D  G  +NG+  F  +LQLG+ + F+CDEG
Sbjct: 663  VARLEFQTDHSTGKRGFNITFTTFRHNECPD-PGVPVNGK-RFGDSLQLGSSISFLCDEG 720

Query: 1290 F-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVF---PFGKA 1345
            F   +GS    CVL     +WNS+V  CE   C      P+G         F       A
Sbjct: 721  FLGTQGSETITCVLKEGSVVWNSAVLRCEAP-CGGHLTSPSGTILSPGWPGFYKDALSCA 779

Query: 1346 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFL----F 1401
                  P      +FD         T + +    +S  AP  G+    Q P   +    +
Sbjct: 780  WVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYS--APLIGVYHGTQVPQFLISTSNY 837

Query: 1402 AKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPV 1461
              L   T+ S   IG  L+YE          +IT              +   C  P  PV
Sbjct: 838  LYLLFSTDKSHSDIGFQLRYE----------TIT-------------LQSDHCLDPGIPV 874

Query: 1462 NGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPT 1521
            NG  H   D  VG+ + +SC +G+ L      EC        WS   P C+ + CG    
Sbjct: 875  NGQRHG-NDFYVGALVTFSCDSGYTLSDGEPLEC---EPNFQWSRALPSCEAL-CGGFIQ 929

Query: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELV-------GEPSIYCTSNDDQVGI 1574
             ++G  +S    +F+  ++        S G+ VF          G   +  T N    G 
Sbjct: 930  GSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN----GS 985

Query: 1575 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN 1634
            ++ P  Q  +     P  +  G+  +             F  Q  F+       +   + 
Sbjct: 986  FTQPLRQ--LTGSRLPAPISAGLYGN-------------FTAQVRFISDFSMSYEGFNIT 1030

Query: 1635 KWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--P 1692
              E +L  C     P   I  G         F  G  + +SC PGY L G A + C    
Sbjct: 1031 FSEYDLEPCEEPEVPAYSIRKGL-------QFGVGDTLTFSCFPGYRLEGTARITCLGGR 1083

Query: 1693 QGDWSPEAPRCAVKSCDDFLGQLPHGRVL---FPLN------------------LQLGAK 1731
            +  WS   PRC  +  +   G    G +L   FP+N                  +QL A+
Sbjct: 1084 RRLWSSPLPRCVAECGNSVTG--TQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKAR 1141

Query: 1732 VSFVCDEGFRLK---GSS--------VSHCVLVGM------RSLWNNSVPVCEH------ 1768
             +F   EG  LK   G++         SH  ++G+       SLW + +   E+      
Sbjct: 1142 -AFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFE 1200

Query: 1769 --------IFCPNPPAILNGRHTGTPSGDIPY-------GKEISYTCDPHPDRGMTFNLI 1813
                    I C +P         GTP             G  +S++CDP       ++L 
Sbjct: 1201 LHFSSFELIKCEDP---------GTPKFGYKVHDEGHFAGSSVSFSCDP------GYSLR 1245

Query: 1814 GESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLN 1873
            G   + C S       W  P P C ++   G  +        SP  P   +E  +     
Sbjct: 1246 GSEELLCLSGE--RRTWDRPLPTC-VAECGGTVRGEVSGQVLSPGYPA-PYEHNLNCIWT 1301

Query: 1874 YECRPG-YFGKMFSISCLENL-----VWSS-VEDNCRRKSCGPPPEPFNGMVHINTDTQF 1926
             E   G   G  F +   E +     +W   VE     K    P  P +     N+    
Sbjct: 1302 IEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQ 1361

Query: 1927 GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRT 1986
             ST  ++  +GF +  S ST                     SC  P    NG   S +  
Sbjct: 1362 FSTDFFTSKQGFAIQFSVSTA-------------------TSCNDPGIPQNG---SRSGD 1399

Query: 1987 SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 2037
            S+  G    +QC  G      + L G   I C   +++   W   PP CI+
Sbjct: 1400 SWEAGDSTVFQCDPG------YALQGSAEISCVKIENRF-FWQPSPPTCIA 1443



 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 225/1017 (22%), Positives = 342/1017 (33%), Gaps = 243/1017 (23%)

Query: 88   KNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI- 146
            K SV T          C +P  P  G   +    + GS ++++C +GY L GS   TC+ 
Sbjct: 327  KTSVLTQVGVSQGHNMCPDPGIPERGK-RLGSDFRLGSSVQFTCNEGYDLQGSKRITCMK 385

Query: 147  ISGDTVIWDNETPICDRIPC-----GLPPTITNGDFISTNRENFHYGSVVTYRCNP---- 197
            +S     W +  P+C    C     G    IT+ +F      N H   ++T   NP    
Sbjct: 386  VSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIIT-ALNPSKVI 444

Query: 198  ------------------GSGGRK------VFELVGE--PSIYCTSNDDQVGIWSGPAPQ 231
                              G GG+       ++ L G   P +  ++N     ++      
Sbjct: 445  KLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSG 504

Query: 232  CIIPNKCTPPNVEN------GILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 283
              +  K +   +E       GI     R  S F   + ++F CQP F + G + + CQ  
Sbjct: 505  SSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKN 564

Query: 284  NKWEPELPSCSRVC----QPPPDVLHAERTQRDKDNF---------SPGQEVFYS----- 325
            N+W  + P C   C      P  V+ +     D  N           P   +  +     
Sbjct: 565  NQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDID 624

Query: 326  CEPGYDL-------RGAASMRCTPQGDWSPAA---------------------------P 351
             EP +D           A +  T  G+  P++                            
Sbjct: 625  VEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFT 684

Query: 352  TCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWN 410
            T     C D  G  +NG+  F  +LQLG+ + F+CDEGF   +GS    CVL     +WN
Sbjct: 685  TFRHNECPD-PGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWN 742

Query: 411  SSVPVCE-----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            S+V  CE      +  PS  ++  G   G   +       +     P      +FD    
Sbjct: 743  SAVLRCEAPCGGHLTSPSGTILSPG-WPGFYKDALSCAWVIE--AQPGYPIKITFDRFKT 799

Query: 466  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFL----FAKLKTQTNASDFPIGTSLKY 521
                 T + +    +S  AP  G+    Q P   +    +  L   T+ S   IG  L+Y
Sbjct: 800  EVNYDTLEVRDGRTYS--APLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRY 857

Query: 522  ECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSC 581
            E          +IT              +   C  P  PVNG  H   D  VG+ + +SC
Sbjct: 858  E----------TIT-------------LQSDHCLDPGIPVNGQRHG-NDFYVGALVTFSC 893

Query: 582  TTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVV 641
             +G+ L      EC  +     WS   P C+ + CG     ++G  +S    +F+  ++ 
Sbjct: 894  DSGYTLSDGEPLECEPN---FQWSRALPSCEAL-CGGFIQGSSGTILSPGFPDFYPNNLN 949

Query: 642  TYRCNPGSGGRKVFELV-------GEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 694
                   S G+ VF          G   +  T N    G ++ P  Q  +     P  + 
Sbjct: 950  CTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN----GSFTQPLRQ--LTGSRLPAPIS 1003

Query: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVL 754
             G+  +             F  Q  F+       +   +   E +L  C     P   + 
Sbjct: 1004 AGLYGN-------------FTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSI- 1049

Query: 755  HAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVK---SCD 809
                  R    F  G  + +SC PGY L G A + C    +  WS   P C  +   S  
Sbjct: 1050 ------RKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT 1103

Query: 810  DFMGQLLNGRVLFPVN------------------LQLGAKVDFVCDEGFQLK-----GSS 846
               G LL+    FPVN                  +QL A+  F   EG  LK      +S
Sbjct: 1104 GTQGTLLSPN--FPVNYNNNHECIYSIQTQPGKGIQLKARA-FELSEGDVLKVYDGNNNS 1160

Query: 847  A------SYCVLAGM------ESLWNSSVPVCEQ--------------IFCPSPPVIPNG 880
            A      S+  + G+       SLW   +   E               I C  P     G
Sbjct: 1161 ARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFG 1220

Query: 881  RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
                   E    G +V+++CDP       + L G   + C S  +    W  P P C
Sbjct: 1221 YKVHD--EGHFAGSSVSFSCDP------GYSLRGSEELLCLSGER--RTWDRPLPTC 1267



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 111/451 (24%), Positives = 161/451 (35%), Gaps = 110/451 (24%)

Query: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965
            C  P  P  G   + +D + GS+V ++CNEG+ L GS   TC+ VS     W    P+C 
Sbjct: 343  CPDPGIPERGK-RLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCR 401

Query: 1966 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 2000
               C+     P   I++ +F   Y NN       T+ +   V+            Y   T
Sbjct: 402  ARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLT 461

Query: 2001 ----GPDGEQ---LFELVG----------ERSIYCTSKDDQVG--VWSSPPPRCISTNKC 2041
                G DG+Q   L+ L G             ++   + D  G  +        I    C
Sbjct: 462  VGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSC 521

Query: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQ 2101
              P +    R  G+R  F   + ++F CQP F +VG   + CQ N +W  K P C   C 
Sbjct: 522  GDPGIPAYGRREGSR--FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC- 578

Query: 2102 PPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT------PQGDWSPEAPR 2155
                            NF+    V  S  P+Y       LHC       P+         
Sbjct: 579  --------------FFNFTSPSGVVLS--PNYPEDYGNHLHCVWLILARPESRIHLAFND 622

Query: 2156 CTVKSCDDFL----GQLPHGRVL-------LPLNLQLG---AKVSFVCDEGFRLKGRSAS 2201
              V+   DFL    G      VL       LP ++      A++ F  D     +G    
Sbjct: 623  IDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRG---- 678

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGD-IPYGKEISYACDTHPDRG 2260
                      +N +        CP+P   +NG+     FGD +  G  IS+ CD      
Sbjct: 679  ----------FNITFTTFRHNECPDPGVPVNGKR----FGDSLQLGSSISFLCDEG---- 720

Query: 2261 MTFNLIGESSIRCTSDPQGNGVWSSPAPRCE 2291
                  G  +I C    +G+ VW+S   RCE
Sbjct: 721  -FLGTQGSETITCVL-KEGSVVWNSAVLRCE 749



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 172/805 (21%), Positives = 267/805 (33%), Gaps = 207/805 (25%)

Query: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECI-LSGNTAHWSTKPPICQ 1512
            C  P  P  G   + +D ++GS + ++C  G+ L G     C+ +S   A WS   P+C+
Sbjct: 343  CPDPGIPERGK-RLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCR 401

Query: 1513 RIPC-----GLPPTIANGDFISTNRENFHYGSVVTY---------------------RCN 1546
               C     G    I + +F      N H   ++T                         
Sbjct: 402  ARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLT 461

Query: 1547 LGSRGRK------VFELVGE--PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG-- 1596
            +G  G+       ++ L G   P +  ++N     ++        +  K +   +E G  
Sbjct: 462  VGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSC 521

Query: 1597 ----ILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELP----SCSRV 1646
                I     R  S F   + ++F CQP F + G + + CQ  N+W  + P    SC   
Sbjct: 522  GDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN 581

Query: 1647 CQPPPEILHGEHTPSHQDNF---------SPGQEVFYS-----CEPGYD---LRGAASLH 1689
               P  ++   + P    N           P   +  +      EP +D   ++  A+  
Sbjct: 582  FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAE 641

Query: 1690 CTPQGDWSPEAPRCAVKSC----------DDFLGQ-------------------LPHGRV 1720
                G +S      ++ S           D   G+                   +P    
Sbjct: 642  APVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGK 701

Query: 1721 LFPLNLQLGAKVSFVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILN 1779
             F  +LQLG+ +SF+CDEGF   +GS    CVL     +WN++V  CE       P    
Sbjct: 702  RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCE------APC--- 752

Query: 1780 GRHTGTPSGDI-----PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNG 1828
            G H  +PSG I     P   + + +C       P     +TF+         T +     
Sbjct: 753  GGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGR 812

Query: 1829 VWSSPAPRCELSVRAGHCKTPEQFPFASPT-----IPINDFEFPVGTSLNYECRPGYFGK 1883
             +S+P       +   H     QF  ++          +     +G  L YE        
Sbjct: 813  TYSAPL------IGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETI-----T 861

Query: 1884 MFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGS 1943
            + S  CL+                  P  P NG  H N D   G+ V +SC+ G+ L   
Sbjct: 862  LQSDHCLD------------------PGIPVNGQRHGN-DFYVGALVTFSCDSGYTLSDG 902

Query: 1944 PSTTCLVSGNNVTWDKKAPICE-----IISCEPPPTISNG--DFYSNN-------RTSFH 1989
                C     N  W +  P CE      I       +S G  DFY NN        TS  
Sbjct: 903  EPLEC---EPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHG 959

Query: 1990 NG---TVVTYQCHTGPD----------GEQLFELVGERSIYCTSKDDQVGVWS--SPPPR 2034
             G   T  T+   +G D           + L +L G R           G++   +   R
Sbjct: 960  KGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSR----LPAPISAGLYGNFTAQVR 1015

Query: 2035 CIS-----------------TNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVG 2077
             IS                    C  PEV       G +  F + + + F C PG+ + G
Sbjct: 1016 FISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQ--FGVGDTLTFSCFPGYRLEG 1073

Query: 2078 SHTVQCQTNGR--WGPKLPHCSRVC 2100
            +  + C    R  W   LP C   C
Sbjct: 1074 TARITCLGGRRRLWSSPLPRCVAEC 1098



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 132/654 (20%), Positives = 209/654 (31%), Gaps = 181/654 (27%)

Query: 1903 RRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFR-LIGSPSTTCLVSGNNVTWDKKA 1961
            R   C  P  P NG        Q GS++++ C+EGF    GS + TC++   +V W+   
Sbjct: 687  RHNECPDPGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNG------------------------TVVTYQ 1997
              CE   C    T  +G   S     F+                          T V Y 
Sbjct: 746  LRCEA-PCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYD 804

Query: 1998 CHTGPDGEQL---------------FELVGERSIYCTSKDDQ----VGVWSSPPPRCIST 2038
                 DG                  F +     +Y     D+    +G         + +
Sbjct: 805  TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864

Query: 2039 NKCTAPEVENAIRVPGNR--SFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC 2096
            + C  P     I V G R  + F +  ++ F C  G+ +     ++C+ N +W   LP C
Sbjct: 865  DHCLDP----GIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920

Query: 2097 SR------------VCQPP-PEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC 2143
                          +  P  P+        +     S G+ VF++    +   G   L  
Sbjct: 921  EALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLI 980

Query: 2144 TPQGDWSPEAPRCT-------------------VKSCDDFL------------------- 2165
            T  G ++    + T                   V+   DF                    
Sbjct: 981  TENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCE 1040

Query: 2166 -GQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQ--- 2221
              ++P   +   L   +G  ++F C  G+RL+G +   C L G + LW+S +P C     
Sbjct: 1041 EPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITC-LGGRRRLWSSPLPRCVAECG 1099

Query: 2222 ---------IFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNL----IGE 2268
                     +  PN P   N  H            E  Y+  T P +G+        + E
Sbjct: 1100 NSVTGTQGTLLSPNFPVNYNNNH------------ECIYSIQTQPGKGIQLKARAFELSE 1147

Query: 2269 SSIRCTSDPQGN-----GVWS-SPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMT 2322
              +    D   N     GV+S S      L+  ++                 SL+L  +T
Sbjct: 1148 GDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSS-----------------SLWLDFIT 1190

Query: 2323 ISYICDPGYLLVGKGF--IFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHY 2380
             +     G+ L    F  I C D G                P F   +  E      +  
Sbjct: 1191 DAENTSKGFELHFSSFELIKCEDPGT---------------PKFGYKVHDE-----GHFA 1230

Query: 2381 GDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTSRTHDALIVGTLSGTI 2432
            G  V+  C+ GY+L GS    C + +R  WD PL  C +      + G +SG +
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAEC-GGTVRGEVSGQV 1283



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 104/483 (21%), Positives = 171/483 (35%), Gaps = 85/483 (17%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPS--- 1642
            P  + NGI      S F+L + V + C  GF ++G   + C A ++    W+  LPS   
Sbjct: 142  PGRLPNGI---QQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRA 198

Query: 1643 ---CSRVCQPPPEILHGEHTPSHQDNFSP---------GQEVF-----YSCEPGYDLRGA 1685
               C    +    I+   H PS   N +          G  +      +  E GYD    
Sbjct: 199  DDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEV 258

Query: 1686 ASLHCTPQGDWSPEAPRCAVKSCD----DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFR 1741
                 +         P   + S +     F     H +  F    Q+  ++  +   G +
Sbjct: 259  TGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIE-LKSRGVK 317

Query: 1742 L---KGSSVSHCVLVGMRSLWNNSVPVCE-HIFCPNPPAILNGRHTGTPSGDIPYGKEIS 1797
            L   K +S    VL          V V + H  CP+P     G+  G+   D   G  + 
Sbjct: 318  LMPSKDNSQKTSVL--------TQVGVSQGHNMCPDPGIPERGKRLGS---DFRLGSSVQ 366

Query: 1798 YTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASP 1857
            +TC+        ++L G   I C         WS   P C   +   H + P      SP
Sbjct: 367  FTCNE------GYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGI-ITSP 419

Query: 1858 TIPI----NDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEP 1913
              PI    N     + T+LN    P    K+      E        D       G   + 
Sbjct: 420  NFPIQYDNNAHCVWIITALN----PSKVIKL----AFEEFDLERGYDTLTVGDGGQDGDQ 471

Query: 1914 FNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPP 1973
               +++I T T     +  + ++ + L  +       SG+++ +       E  SC  P 
Sbjct: 472  -KTVLYILTGTSVPDLIVSTNHQMWLLFQTDG-----SGSSLGFKASYEEIEQGSCGDPG 525

Query: 1974 TISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPP 2033
              + G       + FH+G  + ++C      +  FELVG+++I C  K++Q   WS+  P
Sbjct: 526  IPAYG---RREGSRFHHGDTLKFEC------QPAFELVGQKAITC-QKNNQ---WSAKKP 572

Query: 2034 RCI 2036
             C+
Sbjct: 573  GCV 575



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 111/530 (20%), Positives = 180/530 (33%), Gaps = 107/530 (20%)

Query: 1910 PPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1969
            PP+P N    +       + V+ +     RLI   + +    G + T++    +    +C
Sbjct: 86   PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSA--QGFHATYE----VLPSHTC 139

Query: 1970 EPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWS 2029
              P  + NG       ++F+ G  V Y C+ G      F L G   + C +  +    W 
Sbjct: 140  GNPGRLPNG---IQQGSTFNLGDKVRYSCNLG------FFLEGHAVLTCHAGSENSATWD 190

Query: 2030 SPPPRCISTNKC-----------TAPEVENAIRVPGNRSFFTLTEI--------IRFRCQ 2070
             P P C + + C           ++P   +      + ++  L E+        I F+ +
Sbjct: 191  FPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLE 250

Query: 2071 PGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGE----HTLSHQDNFSPGQEVF 2126
             G+  +       +  G  G  L   +    P P I        H  S  ++   G    
Sbjct: 251  DGYDFL-------EVTGTEGSSL-WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQ 302

Query: 2127 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTV-------KSCDDFLGQLPHGRVLLPLNL 2179
            Y  +   +L+ +  +   P  D S +    T          C D    +P     L  + 
Sbjct: 303  YQVKKQIELK-SRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPD--PGIPERGKRLGSDF 359

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC-------------P 2225
            +LG+ V F C+EG+ L+G     C+ ++ M A W+   PVC    C             P
Sbjct: 360  RLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSP 419

Query: 2226 N-PPAILNGRHTGTPFGDIPYGKEISYACDTHP-DRGMTFNLIGESS-----------IR 2272
            N P    N  H       +   K I  A +    +RG     +G+             + 
Sbjct: 420  NFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILT 479

Query: 2273 CTSDP--------------QGNGVWSSPAPRC--ELSVPAACPHPPKIQNGHYIGGHVSL 2316
             TS P              Q +G  SS   +   E     +C  P     G   G   S 
Sbjct: 480  GTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREG---SR 536

Query: 2317 YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMN 2366
            +  G T+ + C P + LVG+  I C     WS      K+  C F  F N
Sbjct: 537  FHHGDTLKFECQPAFELVGQKAITCQKNNQWS-----AKKPGCVFSCFFN 581



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 155/722 (21%), Positives = 240/722 (33%), Gaps = 174/722 (24%)

Query: 1541 VTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV-ENGILV 1599
            V  +  L SRG K+  +  + +   TS   QVG+  G        N C  P + E G  +
Sbjct: 305  VKKQIELKSRGVKL--MPSKDNSQKTSVLTQVGVSQGH-------NMCPDPGIPERGKRL 355

Query: 1600 SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN----KWEPELPSC-SRVC----QPP 1650
              +   F L   V+F C  G+ ++G +R+ C  ++     W    P C +R+C    + P
Sbjct: 356  GSD---FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGP 412

Query: 1651 PEILHGEHTPSHQDN----------FSPGQEVFYSCEPGYDL-RGAASLHCTPQGDWSPE 1699
              I+   + P   DN           +P + +  + E  +DL RG  +L     GD   +
Sbjct: 413  SGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEE-FDLERGYDTL---TVGDGGQD 468

Query: 1700 APRCAV------KSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLV 1753
              +  V       S  D +    H   L                  F+  GS  S    +
Sbjct: 469  GDQKTVLYILTGTSVPDLIVSTNHQMWLL-----------------FQTDGSGSS----L 507

Query: 1754 GMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLI 1813
            G ++    S    E   C +P     GR  G+      +G  + + C P       F L+
Sbjct: 508  GFKA----SYEEIEQGSCGDPGIPAYGRREGS---RFHHGDTLKFECQP------AFELV 554

Query: 1814 GESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLN 1873
            G+  I C      N  WS+  P C  S           F F SP+  +    +P     +
Sbjct: 555  GQKAITCQK----NNQWSAKKPGCVFSC---------FFNFTSPSGVVLSPNYPEDYGNH 601

Query: 1874 YEC------RP-GYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1925
              C      RP       F+ I       +  ++D    ++  P    F+G        Q
Sbjct: 602  LHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEA--PVLGTFSG-------NQ 652

Query: 1926 FGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNR 1985
              S++  S     RL      +    G N+T+           C  P    NG  + +  
Sbjct: 653  LPSSIT-SSGHVARLEFQTDHSTGKRGFNITF----TTFRHNECPDPGVPVNGKRFGD-- 705

Query: 1986 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 2045
             S   G+ +++ C  G  G Q     G  +I C  K+  V VW+S   RC +        
Sbjct: 706  -SLQLGSSISFLCDEGFLGTQ-----GSETITCVLKEGSV-VWNSAVLRCEAPCGGHLTS 758

Query: 2046 VENAIRVPGNRSFF--TLTEIIRFRCQPGFVM----------VGSHTVQCQTNGRWGPKL 2093
                I  PG   F+   L+       QPG+ +          V   T++ +    +   L
Sbjct: 759  PSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPL 818

Query: 2094 PHCSRVCQPPPEILHGEHTL--------SHQD---------------------------- 2117
                   Q P  ++   + L        SH D                            
Sbjct: 819  IGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQR 878

Query: 2118 ---NFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVL 2174
               +F  G  V +SC+  Y L     L C P   WS   P C    C  F+ Q   G +L
Sbjct: 879  HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEA-LCGGFI-QGSSGTIL 936

Query: 2175 LP 2176
             P
Sbjct: 937  SP 938



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 25/60 (41%), Positives = 29/60 (48%), Gaps = 2/60 (3%)

Query: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWDKKAPIC 1964
            +CG P    NG+   +T    G  V YSCN GF L G    TC   S N+ TWD   P C
Sbjct: 138  TCGNPGRLPNGIQQGST-FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 37/133 (27%), Positives = 49/133 (36%), Gaps = 17/133 (12%)

Query: 1457 PPDPVNGMVHVITDIQVGSRINYSCTT-GHRLIGHSSAECILSGNTAHWSTKPPICQRIP 1515
            PP P N     +T  Q+ + I  + TT   RLI   +      G  A +   P       
Sbjct: 86   PPQPENLRTR-LTGFQLPATIVSAATTLSLRLISDYAVSA--QGFHATYEVLPSHT---- 138

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            CG P  + NG         F+ G  V Y CNLG      F L G   + C +  +    W
Sbjct: 139  CGNPGRLPNG---IQQGSTFNLGDKVRYSCNLG------FFLEGHAVLTCHAGSENSATW 189

Query: 1576 SGPAPQCIIPNKC 1588
              P P C   + C
Sbjct: 190  DFPLPSCRADDAC 202



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 9/67 (13%)

Query: 421 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 480
           C +P  +PNG   G     F  G  V Y+C+        F L G + + C +  + +  W
Sbjct: 139 CGNPGRLPNGIQQGS---TFNLGDKVRYSCN------LGFFLEGHAVLTCHAGSENSATW 189

Query: 481 SSPAPRC 487
             P P C
Sbjct: 190 DFPLPSC 196



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 9/67 (13%)

Query: 871 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 930
           C +P  +PNG   G     F  G  V Y+C+        F L G + + C +  + +  W
Sbjct: 139 CGNPGRLPNGIQQGS---TFNLGDKVRYSCN------LGFFLEGHAVLTCHAGSENSATW 189

Query: 931 SSPAPRC 937
             P P C
Sbjct: 190 DFPLPSC 196



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 9/67 (13%)

Query: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 1380
            C +P  +PNG   G     F  G  V Y+C+        F L G + + C +  + +  W
Sbjct: 139  CGNPGRLPNGIQQGS---TFNLGDKVRYSCN------LGFFLEGHAVLTCHAGSENSATW 189

Query: 1381 SSPAPRC 1387
              P P C
Sbjct: 190  DFPLPSC 196



 Score = 35.8 bits (81), Expect = 0.54
 Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 18/131 (13%)

Query: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVP---------VCEHIFCPNPPAILNGRHTGTPSGD 1789
            GF+L  + VS    + +R + + +V          V     C NP  + NG   G+    
Sbjct: 98   GFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFN- 156

Query: 1790 IPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849
               G ++ Y+C+      + F L G + + C +    +  W  P P C      G     
Sbjct: 157  --LGDKVRYSCN------LGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRG 208

Query: 1850 EQFPFASPTIP 1860
            +    +SP  P
Sbjct: 209  QSGIISSPHFP 219



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 2/67 (2%)

Query: 547 DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWS 605
           +V    +C  P    NG+    T   +G ++ YSC  G  L GH+   C   S N+A W 
Sbjct: 132 EVLPSHTCGNPGRLPNGIQQGST-FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWD 190

Query: 606 TKPPICQ 612
              P C+
Sbjct: 191 FPLPSCR 197



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 2/67 (2%)

Query: 997  DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWS 1055
            +V    +C  P    NG+    T   +G ++ YSC  G  L GH+   C   S N+A W 
Sbjct: 132  EVLPSHTCGNPGRLPNGIQQGST-FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWD 190

Query: 1056 TKPPICQ 1062
               P C+
Sbjct: 191  FPLPSCR 197



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 2/67 (2%)

Query: 1447 DVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWS 1505
            +V    +C  P    NG+    T   +G ++ YSC  G  L GH+   C   S N+A W 
Sbjct: 132  EVLPSHTCGNPGRLPNGIQQGST-FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWD 190

Query: 1506 TKPPICQ 1512
               P C+
Sbjct: 191  FPLPSCR 197



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 5/59 (8%)

Query: 2378 YHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFIL 2436
            ++ G  VT  C+ GYTL      +C+ + +W   L  C     +AL  G + G+   IL
Sbjct: 883  FYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC-----EALCGGFIQGSSGTIL 936



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 103 SCRNPPDPVNGMVHVIKGIQF--GSQIKYSCTKGYRLIGSSSATCII-SGDTVIWDNETP 159
           +C NP    NG   + +G  F  G +++YSC  G+ L G +  TC   S ++  WD   P
Sbjct: 138 TCGNPGRLPNG---IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLP 194

Query: 160 IC 161
            C
Sbjct: 195 SC 196



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 7/58 (12%)

Query: 240 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 293
           P  + NGI      S F+L + V + C  GF ++G   + C A ++    W+  LPSC
Sbjct: 142 PGRLPNGI---QQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 7/58 (12%)

Query: 690 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 743
           P  + NGI      S F+L + V + C  GF ++G   + C A ++    W+  LPSC
Sbjct: 142 PGRLPNGI---QQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 7/58 (12%)

Query: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1193
            P  + NGI      S F+L + V + C  GF ++G   + C A ++    W+  LPSC
Sbjct: 142  PGRLPNGI---QQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196


>gi|4502503 complement component 4 binding protein, alpha chain
            precursor [Homo sapiens]
          Length = 597

 Score =  221 bits (563), Expect = 7e-57
 Identities = 158/521 (30%), Positives = 229/521 (43%), Gaps = 54/521 (10%)

Query: 1844 GHCKTPEQFPFASPT-IPINDFEFPVGTSLNYECRPGYFGKMFS--ISCLENLVWSSVED 1900
            G+C  P    FA+P  I + +  F  GT+L Y C PGY     +  ++C  +  W     
Sbjct: 48   GNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNT 106

Query: 1901 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1960
             C  K C  P E  NG V I TD  FGS + +SC+EGF LIGS ++ C V    V W   
Sbjct: 107  FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166

Query: 1961 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 2020
             P CEI+ C+PPP I NG  +S     +  G  VTY C      +  F L+G  SI CT 
Sbjct: 167  LPQCEIVKCKPPPDIRNGR-HSGEENFYAYGFSVTYSC------DPRFSLLGHASISCTV 219

Query: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
            +++ +GVW   PP C     C  P+V +   V G    +   + I F+CQ GFV+ GS  
Sbjct: 220  ENETIGVWRPSPPTCEKIT-CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278

Query: 2081 VQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTL----SHQDNFSPGQEVFYSCEPSY-- 2133
            + C  + +W P  P C    C   P+I H         + +D +  G  + Y C P Y  
Sbjct: 279  IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKP 338

Query: 2134 DLRGAASLHCTPQGDWSP----EAPRCTVKSCDDFLGQLPHGRVLLPLN---LQLGAKVS 2186
                  ++ C     W+P    EA  C     ++  G++   R   P N      G ++S
Sbjct: 339  TTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNN--GEITQHRKSRPANHCVYFYGDEIS 396

Query: 2187 FVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYG 2246
            F C E  R          +      W+   P C  I C  PP I +G +  +      + 
Sbjct: 397  FSCHETSRFS-------AICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF-FK 447

Query: 2247 KEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
            +EI Y CD        + L+G++ + C+        WS+PAP+C+    A C   P++ N
Sbjct: 448  EEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCK----ALC-RKPELVN 491

Query: 2307 GHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIW 2347
            G  +      Y+    ++  CD GY +VG   I C+    W
Sbjct: 492  GR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTW 531



 Score =  221 bits (562), Expect = 9e-57
 Identities = 158/537 (29%), Positives = 244/537 (45%), Gaps = 52/537 (9%)

Query: 31  VVLLALPVAWGQCNAPEWLPFARPTNLT-DEFEFPIGTYLNYECRPGY--SGRPFSIICL 87
           ++   LP   G C  P  L FA P ++T  E  F  GT L Y C PGY  S    ++ C 
Sbjct: 38  LIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97

Query: 88  KNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII 147
            +  W      C  K CR+P +  NG V +   + FGSQI++SC++G+ LIGS+++ C +
Sbjct: 98  SDGEWV-YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEV 156

Query: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFE 206
               V W +  P C+ + C  PP I NG    +  ENF+ YG  VTY C+P       F 
Sbjct: 157 QDRGVGWSHPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FS 208

Query: 207 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 266
           L+G  SI CT  ++ +G+W  P+P       C  P+V +G +VS    +++  + + F+C
Sbjct: 209 LLGHASISCTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267

Query: 267 QPGFVMKGPRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQE 321
           Q GFV++G   + C A +KW P  P+C    C   PD+ HA          +D +  G  
Sbjct: 268 QKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTV 327

Query: 322 VFYSCEPGY--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN- 375
           + Y C PGY        ++ C     W+P    CE   C +     G++   R   P N 
Sbjct: 328 LRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANH 386

Query: 376 --LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 433
                G ++ F C E       ++ +  +   +  W+   P C  I C  PP I +G + 
Sbjct: 387 CVYFYGDEISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYK 438

Query: 434 GKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493
                 F F + + Y CD        + L+G++ + C+        WS+PAP+C  L  C
Sbjct: 439 QSSSYSF-FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--C 484

Query: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 550
           + P+  +  +L    +    P   +++ +      G P SITC  N  W      C+
Sbjct: 485 RKPE-LVNGRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539



 Score =  202 bits (514), Expect = 3e-51
 Identities = 151/529 (28%), Positives = 235/529 (44%), Gaps = 52/529 (9%)

Query: 489  ILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS--ITCLDNLVWSSP 545
            +LG+C  P    FA  +      + F  GT+LKY C P Y     +  +TC  +  W   
Sbjct: 46   VLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVY- 104

Query: 546  KDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 605
               C  K C+ P +  NG V + TD+  GS+I +SC+ G  LIG +++ C +      WS
Sbjct: 105  NTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWS 164

Query: 606  TKPPICQRIPCGLPPTIANGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFELVGEPSIY 664
               P C+ + C  PP I NG    +  ENF+ YG  VTY C+P       F L+G  SI 
Sbjct: 165  HPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FSLLGHASIS 216

Query: 665  CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 724
            CT  ++ +G+W  P+P       C  P+V +G +VS    +++  + + F+CQ GFV++G
Sbjct: 217  CTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275

Query: 725  PRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQEVFYSCEPG 779
               + C A +KW P  P+C    C   PD+ HA          +D +  G  + Y C PG
Sbjct: 276  SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335

Query: 780  Y--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN---LQLGAK 831
            Y        ++ C     W+P    CE   C +     G++   R   P N      G +
Sbjct: 336  YKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDE 394

Query: 832  VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 891
            + F C E       ++ +  +   +  W+   P C  I C  PP I +G +       F 
Sbjct: 395  ISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF- 445

Query: 892  FGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 951
            F + + Y CD        + L+G++ + C+        WS+PAP+C  L  C+ P+  + 
Sbjct: 446  FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--CRKPE-LVN 491

Query: 952  AKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 1000
             +L    +    P   +++ +      G P SITC  N  W      C+
Sbjct: 492  GRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539



 Score =  179 bits (453), Expect = 4e-44
 Identities = 148/535 (27%), Positives = 226/535 (42%), Gaps = 62/535 (11%)

Query: 1906 SCGPPPE-PFNGMVHIN-TDTQF--GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961
            +CGPPP   F   + I  T+T+F  G+T+ Y+C  G+  + S ST  L   ++  W    
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY--VRSHSTQTLTCNSDGEWVYNT 106

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C    C  P  + NG        SF  G+ + + C  G      F L+G  +  C  +
Sbjct: 107  -FCIYKRCRHPGELRNGQVEIKTDLSF--GSQIEFSCSEG------FFLIGSTTSRCEVQ 157

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 2081
            D  VG WS P P+C        P++ N  R  G  +F+     + + C P F ++G  ++
Sbjct: 158  DRGVG-WSHPLPQCEIVKCKPPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASI 215

Query: 2082 QC----QTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRG 2137
             C    +T G W P  P C ++    P++ HGE        ++    + + C+  + LRG
Sbjct: 216  SCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275

Query: 2138 AASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHG------RVLLPLNLQLGAKVSFVCDE 2191
            ++ +HC     W+P  P C   SC + L  +PH       R        +G  + + C  
Sbjct: 276  SSVIHCDADSKWNPSPPACEPNSCIN-LPDIPHASWETYPRPTKEDVYVVGTVLRYRCHP 334

Query: 2192 GFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHT----GTPFGDIPY-- 2245
            G+  K  +     +   K L  +    CE + CP P  + NG  T      P     Y  
Sbjct: 335  GY--KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPK-LNNGEITQHRKSRPANHCVYFY 391

Query: 2246 GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQ 2305
            G EIS++C                + R ++  QG+G WS   P C       C  PPKI 
Sbjct: 392  GDEISFSC--------------HETSRFSAICQGDGTWSPRTPSCG----DICNFPPKIA 433

Query: 2306 NGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM 2365
            +GHY       +     I Y CD GY+LVG+  + C+    WS     CK + C  P  +
Sbjct: 434  HGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSCS-YSHWSAPAPQCKAL-CRKPELV 490

Query: 2366 NG-ISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRT 2419
            NG +S +   K  Y   + VT++C+ GY + G     C  +  W P + KC   T
Sbjct: 491  NGRLSVD---KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWET 542



 Score =  178 bits (451), Expect = 7e-44
 Identities = 151/559 (27%), Positives = 241/559 (43%), Gaps = 73/559 (13%)

Query: 740  LPSCSRVCQPPPDVLHAERTQ--RDKDNFSPGQEVFYSCEPGY-DLRGAASMRCTPQGDW 796
            LP+    C PPP +  A        +  F  G  + Y+C PGY       ++ C   G+W
Sbjct: 43   LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102

Query: 797  SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 856
                  C  K C    G+L NG+V    +L  G++++F C EGF L GS+ S C +    
Sbjct: 103  VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160

Query: 857  SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 916
              W+  +P CE + C  PP I NGRH+G+    + +G +V Y+CDP       F L+G +
Sbjct: 161  VGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGHA 213

Query: 917  TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF-PI---GTSLKYE 972
            +I CT + +  GVW    P C  +  C+ PD      +      S F PI     ++ ++
Sbjct: 214  SISCTVENETIGVWRPSPPTCEKI-TCRKPD------VSHGEMVSGFGPIYNYKDTIVFK 266

Query: 973  CRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSC-----------KTPPDPVNGMVHVITD 1020
            C+  +  R  S I C  +  W+     C+  SC           +T P P    V+V   
Sbjct: 267  CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV--- 323

Query: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 1080
              VG+ + Y C  G++         I   N   W T    C+ + C   P + NG+ I+ 
Sbjct: 324  --VGTVLRYRCHPGYKPTTDEPTTVICQKN-LRW-TPYQGCEALCCP-EPKLNNGE-ITQ 377

Query: 1081 NREN-------FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
            +R++       + YG  +++ C+  S            S  C  +    G WS   P C 
Sbjct: 378  HRKSRPANHCVYFYGDEISFSCHETS----------RFSAICQGD----GTWSPRTPSC- 422

Query: 1134 IPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1192
              + C  PP + +G     +   F   E++ + C  G+++ G  ++ C + + W    P 
Sbjct: 423  -GDICNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC-SYSHWSAPAPQ 479

Query: 1193 CSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 1252
            C  +C+ P   L   R   DKD +   + V   C+ GY + G  S+ C+    W P  P 
Sbjct: 480  CKALCRKPE--LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537

Query: 1253 CEVKSCDDFMGQLLNGRVL 1271
            CE ++  +   Q+L G+ L
Sbjct: 538  CEWET-PEGCEQVLTGKRL 555



 Score =  178 bits (451), Expect = 7e-44
 Identities = 146/541 (26%), Positives = 237/541 (43%), Gaps = 72/541 (13%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQ--RDKDNFSPGQEVFYSCEPGY-DLRGAASMRCTPQGDW 1246
            LP+    C PPP +  A        +  F  G  + Y+C PGY       ++ C   G+W
Sbjct: 43   LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102

Query: 1247 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 1306
                  C  K C    G+L NG+V    +L  G++++F C EGF L GS+ S C +    
Sbjct: 103  VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160

Query: 1307 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGES 1366
              W+  +P CE + C  PP I NGRH+G+    + +G +V Y+CDP       F L+G +
Sbjct: 161  VGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGHA 213

Query: 1367 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF-PI---GTSLKYE 1422
            +I CT + +  GVW    P C  +  C+ PD      +      S F PI     ++ ++
Sbjct: 214  SISCTVENETIGVWRPSPPTCEKI-TCRKPD------VSHGEMVSGFGPIYNYKDTIVFK 266

Query: 1423 CRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSC-----------KTPPDPVNGMVHVITD 1470
            C+  +  R  S I C  +  W+     C+  SC           +T P P    V+V   
Sbjct: 267  CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV--- 323

Query: 1471 IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST 1530
              VG+ + Y C  G++         I   N   W T    C+ + C   P + NG+ I+ 
Sbjct: 324  --VGTVLRYRCHPGYKPTTDEPTTVICQKN-LRW-TPYQGCEALCCP-EPKLNNGE-ITQ 377

Query: 1531 NREN-------FHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1583
            +R++       + YG  +++ C+  SR           S  C  +    G WS   P C 
Sbjct: 378  HRKSRPANHCVYFYGDEISFSCHETSRF----------SAICQGD----GTWSPRTPSC- 422

Query: 1584 IPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1642
              + C  PP + +G     +   F   E++ + C  G+++ G  ++ C + + W    P 
Sbjct: 423  -GDICNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC-SYSHWSAPAPQ 479

Query: 1643 CSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPR 1702
            C  +C+  PE+++G  +   +D +   + V   C+ GY + G  S+ C+    W PE P+
Sbjct: 480  CKALCR-KPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537

Query: 1703 C 1703
            C
Sbjct: 538  C 538



 Score =  177 bits (450), Expect = 9e-44
 Identities = 143/530 (26%), Positives = 220/530 (41%), Gaps = 107/530 (20%)

Query: 1640 LPSCSRVCQPPPEILHGE--HTPSHQDNFSPGQEVFYSCEPGY-DLRGAASLHCTPQGDW 1696
            LP+    C PPP +           +  F  G  + Y+C PGY       +L C   G+W
Sbjct: 43   LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102

Query: 1697 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMR 1756
                  C  K C    G+L +G+V    +L  G+++ F C EGF L GS+ S C +    
Sbjct: 103  VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160

Query: 1757 SLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES 1816
              W++ +P CE + C  PP I NGRH+G       YG  ++Y+CDP       F+L+G +
Sbjct: 161  VGWSHPLPQCEIVKCKPPPDIRNGRHSG-EENFYAYGFSVTYSCDPR------FSLLGHA 213

Query: 1817 TIRCTSDPHGNGVWSSPAPRCEL------SVRAG-------------------------- 1844
            +I CT +    GVW    P CE        V  G                          
Sbjct: 214  SISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL 273

Query: 1845 ------HCKTPEQF----PFASPTIPINDFEFP-----------------VGTSLNYECR 1877
                  HC    ++    P   P   IN  + P                 VGT L Y C 
Sbjct: 274  RGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCH 333

Query: 1878 PGY---FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ--------F 1926
            PGY     +  ++ C +NL W+  +  C    C P P+  NG +  +  ++        +
Sbjct: 334  PGYKPTTDEPTTVICQKNLRWTPYQ-GCEALCC-PEPKLNNGEITQHRKSRPANHCVYFY 391

Query: 1927 GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRT 1986
            G  +++SC+E  R     S  C   G   TW  + P C  I C  PP I++G +  ++  
Sbjct: 392  GDEISFSCHETSRF----SAICQGDG---TWSPRTPSCGDI-CNFPPKIAHGHYKQSSSY 443

Query: 1987 SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEV 2046
            SF    ++ Y+C  G      + LVG+  + C+        WS+P P+C +   C  PE+
Sbjct: 444  SFFKEEII-YECDKG------YILVGQAKLSCSYSH-----WSAPAPQCKAL--CRKPEL 489

Query: 2047 ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC 2096
             N  R+  ++  +   E +  +C  G+ +VG  ++ C  N  W P++P C
Sbjct: 490  VNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538



 Score =  151 bits (381), Expect = 9e-36
 Identities = 131/521 (25%), Positives = 209/521 (40%), Gaps = 74/521 (14%)

Query: 1469 TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI 1528
            T  + G+ + Y+C  G+  +   S + +   +   W      C    C  P  + NG   
Sbjct: 69   TRFKTGTTLKYTCLPGY--VRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQV- 124

Query: 1529 STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 1588
               + +  +GS + + C+ G      F L+G  +  C   D  VG WS P PQC I    
Sbjct: 125  -EIKTDLSFGSQIEFSCSEG------FFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCK 176

Query: 1589 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSCS 1644
             PP++ NG   S   + ++    V + C P F + G   + C   N+    W P  P+C 
Sbjct: 177  PPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235

Query: 1645 RVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1704
            ++    P++ HGE        ++    + + C+ G+ LRG++ +HC     W+P  P C 
Sbjct: 236  KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACE 295

Query: 1705 VKSCDDFLGQLPHGR-VLFPLNLQ-----LGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1758
              SC + L  +PH     +P   +     +G  + + C  G+  K ++     ++  ++L
Sbjct: 296  PNSCIN-LPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY--KPTTDEPTTVICQKNL 352

Query: 1759 WNNSVPVCEHIFCPNPPAILNGRHT----GTPSGDIP--YGKEISYTCDPHPDRGMTFNL 1812
                   CE + CP  P + NG  T      P+      YG EIS++C            
Sbjct: 353  RWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEISFSC------------ 399

Query: 1813 IGESTIRCTSDPHGNGVWSSPAPRC------ELSVRAGHCKTPEQFPFASPTIPINDFEF 1866
                T R ++   G+G WS   P C         +  GH K    + F    I       
Sbjct: 400  --HETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI------- 450

Query: 1867 PVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1925
                   YEC  GY       +SC  +  WS+    C  K+    PE  NG + ++ D  
Sbjct: 451  ------IYECDKGYILVGQAKLSCSYS-HWSAPAPQC--KALCRKPELVNGRLSVDKDQY 501

Query: 1926 F-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965
                 V   C+ G+ ++G  S TC  SGN  TW  + P CE
Sbjct: 502  VEPENVTIQCDSGYGVVGPQSITC--SGNR-TWYPEVPKCE 539



 Score =  134 bits (337), Expect = 1e-30
 Identities = 96/328 (29%), Positives = 141/328 (42%), Gaps = 24/328 (7%)

Query: 2093 LPHCSRVCQPPPEILHG---EHTLSHQDNFSPGQEVFYSCEPSY-DLRGAASLHCTPQGD 2148
            LP     C PPP +      + TL+ +  F  G  + Y+C P Y       +L C   G+
Sbjct: 43   LPAVLGNCGPPPTLSFAAPMDITLT-ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE 101

Query: 2149 WSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 2208
            W      C  K C    G+L +G+V +  +L  G+++ F C EGF L G + S C +   
Sbjct: 102  WVYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDR 159

Query: 2209 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 2268
               W+  +P CE + C  PP I NGRH+G       YG  ++Y+CD        F+L+G 
Sbjct: 160  GVGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGH 212

Query: 2269 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 2328
            +SI CT + +  GVW    P CE      C   P + +G  + G   +Y    TI + C 
Sbjct: 213  ASISCTVENETIGVWRPSPPTCE---KITC-RKPDVSHGEMVSGFGPIYNYKDTIVFKCQ 268

Query: 2329 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC----SFPLFMNGISKELEMKKVYHYGDYV 2384
             G++L G   I C     W+     C+  +C      P            + VY  G  +
Sbjct: 269  KGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVL 328

Query: 2385 TLKCEDGY--TLEGSPWSQCQADDRWDP 2410
              +C  GY  T +      CQ + RW P
Sbjct: 329  RYRCHPGYKPTTDEPTTVICQKNLRWTP 356


>gi|157419154 selectin P precursor [Homo sapiens]
          Length = 830

 Score =  192 bits (488), Expect = 3e-48
 Identities = 163/631 (25%), Positives = 245/631 (38%), Gaps = 79/631 (12%)

Query: 1616 CQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYS 1675
            C PGF   GP   +C+ + +       C  +  P   +++  H      NFS   +  + 
Sbjct: 185  CYPGFY--GP---ECEYVRE-------CGELELPQHVLMNCSHPLG---NFSFNSQCSFH 229

Query: 1676 CEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLN----LQLGAK 1731
            C  GY + G + L C   G W+ + P+C    C     ++P    +  L+     Q  + 
Sbjct: 230  CTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPL--KIPERGNMTCLHSAKAFQHQSS 287

Query: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDI 1790
             SF C+EGF L G  V  C   G+   W    PVC+ + C +  A   G      P    
Sbjct: 288  CSFSCEEGFALVGPEVVQCTASGV---WTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344

Query: 1791 PYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE 1850
             YG    + C P       + + G   +RC    H    WS+P P CE    A  C+  E
Sbjct: 345  AYGSSCKFECQPG------YRVRGLDMLRCIDSGH----WSAPLPTCE----AISCEPLE 390

Query: 1851 QFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENL-VWSSVEDNCRRKSCGP 1909
                 S     +   F   T+ ++ C  G+  +   I   +NL  W++    C+   C  
Sbjct: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450

Query: 1910 PPEPFNGMVHINTDTQFG-----STVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1964
             P P      +N    FG     S  +++CNEG  L+G+    CL +GN   W+   P C
Sbjct: 451  LPVP--NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPEC 505

Query: 1965 EIISCEPPPTISNGDFYSNNRT-SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 2023
            + I C P  +  NG         S    +   + C  G      + L G   + CT    
Sbjct: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEG------YSLSGPERLDCTRS-- 557

Query: 2024 QVGVWSSPPPRC--ISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 2081
              G W+  PP C  I   +  APE + ++     R  F +     F C  GF + G + V
Sbjct: 558  --GRWTDSPPMCEAIKCPELFAPE-QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNV 614

Query: 2082 QCQTNGRWGPKLPHCSRVC-------QPPPEILHGEHTL---SHQDNFSPGQEVFYSCEP 2131
            +C T+GRW    P C  +        Q P     G+ T+    H   F      ++ C  
Sbjct: 615  ECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNA 674

Query: 2132 SYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPL--NLQLGAKVSFVC 2189
             + L G ++L C P G W+   P C    C +     P       L  N   G+  SF C
Sbjct: 675  GFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734

Query: 2190 DEGFRLKGRSASHCVLAGMKALWNSSVPVCE 2220
             EG  L G + + C   G    W+++VP C+
Sbjct: 735  LEGQLLNGSAQTACQENGH---WSTTVPTCQ 762



 Score =  191 bits (484), Expect = 1e-47
 Identities = 165/633 (26%), Positives = 249/633 (39%), Gaps = 65/633 (10%)

Query: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865
            +G     IG  T  C    +G        P CE     G  + P Q    + + P+ +F 
Sbjct: 171  QGECLETIGNYTCSCYPGFYG--------PECEYVRECGELELP-QHVLMNCSHPLGNFS 221

Query: 1866 FPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNG---MVHIN 1921
            F   +  ++ C  GY       + CL + +W++    C    C P   P  G    +H  
Sbjct: 222  F--NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279

Query: 1922 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFY 1981
               Q  S+ ++SC EGF L+G     C  SG    W   AP+C+ + C+     S G   
Sbjct: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336

Query: 1982 S-NNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC--IST 2038
              +  T+F  G+   ++C  G      + + G   + C       G WS+P P C  IS 
Sbjct: 337  CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAISC 386

Query: 2039 NKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR 2098
                +P   +    P  R+F   T    FRC  GF++ G+  V+C   G+W    P C  
Sbjct: 387  EPLESPVHGSMDCSPSLRAFQYDTNC-SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445

Query: 2099 V-CQPPPEILHGEHTLSHQDNFSPGQEVF-YSCEPSYDLRGAASLHCTPQGDWSPEAPRC 2156
            + CQ  P         SH       Q V  ++C     L GA+ L C   G+W+   P C
Sbjct: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505

Query: 2157 TVKSCDDFLG-QLPHGRVLLPL-NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNS 2214
                C   L  Q      + PL +    +   F+CDEG+ L G     C  +G    W  
Sbjct: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTD 562

Query: 2215 SVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 2273
            S P+CE I CP   A   G        G+   G    ++CD        F L G +++ C
Sbjct: 563  SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNNVEC 616

Query: 2274 TSDPQGNGVWSSPAPRCE--LSVPAACPHPPKI----QNGHYIGGHVSLYLPGMTISYIC 2327
            T+    +G WS+  P C+   S+P      P +    Q   Y   H   +    T  + C
Sbjct: 617  TT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672

Query: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCS-----FPLFMNGISKELEMKKVYHYGD 2382
            + G+ L+G   + C   G W+ +   C+ V CS      P+ MN  +    +   + YG 
Sbjct: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSN----LWGNFSYGS 728

Query: 2383 YVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415
              +  C +G  L GS  + CQ +  W   +  C
Sbjct: 729  ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  181 bits (458), Expect = 1e-44
 Identities = 158/591 (26%), Positives = 235/591 (39%), Gaps = 76/591 (12%)

Query: 1534 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1593
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267

Query: 1594 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 1650
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327

Query: 1651 PEILHGEHTPSHQ-DNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD 1709
                 G     H    F+ G    + C+PGY +RG   L C   G WS   P C   SC+
Sbjct: 328  EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387

Query: 1710 DFLGQLPHGRVLFPLNL---QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVC 1766
              L    HG +    +L   Q     SF C EGF L+G+ +  C  +G    W    PVC
Sbjct: 388  P-LESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPAPVC 443

Query: 1767 EHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPH 1825
            + + C + P     R +   P G   Y    S+TC    + G+   L+G S ++C +   
Sbjct: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTC----NEGLL--LVGASVLQCLA--- 494

Query: 1826 GNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTS-----LNYECRPGY 1880
              G W+S  P C+    A  C      P  SP         P+G+S       + C  GY
Sbjct: 495  -TGNWNSVPPECQ----AIPCT-----PLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGY 544

Query: 1881 -FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT---DTQFGSTVNYSCNE 1936
                   + C  +  W+     C    C     P  G +  +    +   GST ++SC+ 
Sbjct: 545  SLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN 604

Query: 1937 GFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPP--------TISNGDFYSNNRT-S 1987
            GF+L G  +  C  SG    W    P C+ I+  P P        T   G  Y  +   +
Sbjct: 605  GFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661

Query: 1988 FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVE 2047
            F   T   + C+ G      F L+G+ ++ C       G W++  P C +  KC+   V 
Sbjct: 662  FGFNTTCYFGCNAG------FTLIGDSTLSCRPS----GQWTAVTPACRAV-KCSELHVN 710

Query: 2048 NAIRVPGNRSF--FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC 2096
              I +  +  +  F+   I  F C  G ++ GS    CQ NG W   +P C
Sbjct: 711  KPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  177 bits (449), Expect = 1e-43
 Identities = 150/593 (25%), Positives = 229/593 (38%), Gaps = 83/593 (13%)

Query: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243
           NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 219 NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267

Query: 244 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 300
            E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 268 PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325

Query: 301 PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
               H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 326 ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381

Query: 354 EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411
           E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 382 EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438

Query: 412 SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRC 470
             PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 439 PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN------EGLLLVGASVLQC 492

Query: 471 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS-----LKYECRP 525
            +     G W+S  P       CQA         +  T     P+G+S      ++ C  
Sbjct: 493 LA----TGNWNSVPP------ECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542

Query: 526 EY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQVGSRINYSC 581
            Y    P  + C  +  W+    +C+   C     P  G +       +  VGS  ++SC
Sbjct: 543 GYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSC 602

Query: 582 TTGHRLIGHSSAECILSGNAAHWSTKPPICQRI--------PCGLPPTIANGDFISTNRE 633
             G +L G ++ EC  SG    WS  PP C+ I         C    T   G     +  
Sbjct: 603 DNGFKLEGPNNVECTTSG---RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP 659

Query: 634 -NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 692
             F + +   + CN G      F L+G+ ++ C  +    G W+   P C    KC+  +
Sbjct: 660 GTFGFNTTCYFGCNAG------FTLIGDSTLSCRPS----GQWTAVTPACRAV-KCSELH 708

Query: 693 VENGILV--SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
           V   I +  S+    FS   +  F C  G ++ G  +  CQ    W   +P+C
Sbjct: 709 VNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  177 bits (449), Expect = 1e-43
 Identities = 150/593 (25%), Positives = 229/593 (38%), Gaps = 83/593 (13%)

Query: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 693
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267

Query: 694  -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 750
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325

Query: 751  PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803
                H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 326  ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381

Query: 804  EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 861
            E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438

Query: 862  SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRC 920
              PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN------EGLLLVGASVLQC 492

Query: 921  TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS-----LKYECRP 975
             +     G W+S  P       CQA         +  T     P+G+S      ++ C  
Sbjct: 493  LA----TGNWNSVPP------ECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542

Query: 976  EY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQVGSRINYSC 1031
             Y    P  + C  +  W+    +C+   C     P  G +       +  VGS  ++SC
Sbjct: 543  GYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSC 602

Query: 1032 TTGHRLIGHSSAECILSGNAAHWSTKPPICQRI--------PCGLPPTIANGDFISTNRE 1083
              G +L G ++ EC  SG    WS  PP C+ I         C    T   G     +  
Sbjct: 603  DNGFKLEGPNNVECTTSG---RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP 659

Query: 1084 -NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1142
              F + +   + CN G      F L+G+ ++ C  +    G W+   P C    KC+  +
Sbjct: 660  GTFGFNTTCYFGCNAG------FTLIGDSTLSCRPS----GQWTAVTPACRAV-KCSELH 708

Query: 1143 VENGILV--SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1193
            V   I +  S+    FS   +  F C  G ++ G  +  CQ    W   +P+C
Sbjct: 709  VNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  177 bits (449), Expect = 1e-43
 Identities = 150/593 (25%), Positives = 229/593 (38%), Gaps = 83/593 (13%)

Query: 1084 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1143
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267

Query: 1144 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 1200
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325

Query: 1201 PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 1253
                H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 326  ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381

Query: 1254 EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 1311
            E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438

Query: 1312 SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRC 1370
              PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN------EGLLLVGASVLQC 492

Query: 1371 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS-----LKYECRP 1425
             +     G W+S  P       CQA         +  T     P+G+S      ++ C  
Sbjct: 493  LA----TGNWNSVPP------ECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542

Query: 1426 EY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQVGSRINYSC 1481
             Y    P  + C  +  W+    +C+   C     P  G +       +  VGS  ++SC
Sbjct: 543  GYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSC 602

Query: 1482 TTGHRLIGHSSAECILSGNTAHWSTKPPICQRI--------PCGLPPTIANGDFISTNRE 1533
              G +L G ++ EC  SG    WS  PP C+ I         C    T   G     +  
Sbjct: 603  DNGFKLEGPNNVECTTSG---RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP 659

Query: 1534 -NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1592
              F + +   + CN G      F L+G+ ++ C  +    G W+   P C    KC+  +
Sbjct: 660  GTFGFNTTCYFGCNAG------FTLIGDSTLSCRPS----GQWTAVTPACRAV-KCSELH 708

Query: 1593 VENGILV--SDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1643
            V   I +  S+    FS   +  F C  G ++ G  +  CQ    W   +P+C
Sbjct: 709  VNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  176 bits (446), Expect = 3e-43
 Identities = 157/596 (26%), Positives = 242/596 (40%), Gaps = 75/596 (12%)

Query: 1466 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANG 1525
            H + +    S+ ++ CT G+++ G S  EC+ SG    W+ KPP C    C        G
Sbjct: 215  HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271

Query: 1526 DFIST-NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 1583
            +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 272  NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321

Query: 1584 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1643
            +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 322  VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381

Query: 1644 SRV-CQPPPEILHG--EHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEA 1700
              + C+P    +HG  + +PS +  F       + C  G+ LRGA  + C   G W+  A
Sbjct: 382  EAISCEPLESPVHGSMDCSPSLR-AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPA 440

Query: 1701 PRCAVKSCDDF-LGQLPHGRVLFPLN-LQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1758
            P C    C D  +          P    +  +  SF C+EG  L G+SV  C+  G    
Sbjct: 441  PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--- 497

Query: 1759 WNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDIPYGKEISYTCDPHPDRGMTFNLIGEST 1817
            WN+  P C+ I C    +  NG  T   P G   Y     + CD        ++L G   
Sbjct: 498  WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE------GYSLSGPER 551

Query: 1818 IRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLNYE 1875
            + CT     +G W+   P CE        K PE F     ++  +D   EF VG++ ++ 
Sbjct: 552  LDCTR----SGRWTDSPPMCEA------IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS 601

Query: 1876 CRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPP--------EPFNGMV---HINTD 1923
            C  G+      ++ C  +  WS+    C+  +  P P         P  G +   H    
Sbjct: 602  CDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661

Query: 1924 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP----PPTISNGD 1979
              F +T  + CN GF LIG  + +C  SG    W    P C  + C       P   N  
Sbjct: 662  FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMN-- 716

Query: 1980 FYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035
              SN   +F  G++ ++ C  G    QL  L G     C     + G WS+  P C
Sbjct: 717  -CSNLWGNFSYGSICSFHCLEG----QL--LNGSAQTAC----QENGHWSTTVPTC 761



 Score =  175 bits (443), Expect = 6e-43
 Identities = 170/676 (25%), Positives = 268/676 (39%), Gaps = 114/676 (16%)

Query: 1675 SCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSF 1734
            SC PG+   G    +    G+   E P+  + +C   LG           N    ++ SF
Sbjct: 184  SCYPGF--YGPECEYVRECGEL--ELPQHVLMNCSHPLG-----------NFSFNSQCSF 228

Query: 1735 VCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD-IPYG 1793
             C +G+++ G S   C+  G   +W N  P C    CP       G  T   S     + 
Sbjct: 229  HCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ 285

Query: 1794 KEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFP 1853
               S++C+        F L+G   ++CT+    +GVW++PAP C+ +V+  H + P +  
Sbjct: 286  SSCSFSCEEG------FALVGPEVVQCTA----SGVWTAPAPVCK-AVQCQHLEAPSEGT 334

Query: 1854 FASPTIPINDFEFPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSCGPPPE 1912
                  P+  F +  G+S  +EC+PGY  + +  + C+++  WS+    C   SC P   
Sbjct: 335  MDC-VHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLES 391

Query: 1913 PFNGMVHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1969
            P +G +  +      Q+ +  ++ C EGF L G+    C    N   W   AP+C+ + C
Sbjct: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC---DNLGQWTAPAPVCQALQC 448

Query: 1970 EPPPTISNGDFY-SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028
            +  P  +      S+   +F   +V ++ C+ G        LVG   + C +     G W
Sbjct: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEG------LLLVGASVLQCLA----TGNW 498

Query: 2029 SSPPPRC--ISTNKCTAPE--VENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 2084
            +S PP C  I      +P+      ++  G+ S+ +  + I   C  G+ + G   + C 
Sbjct: 499  NSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI---CDEGYSLSGPERLDCT 555

Query: 2085 TNGRWGPKLPHCSRVCQPPPEILHGEH-TLSHQDN---FSPGQEVFYSCEPSYDLRGAAS 2140
             +GRW    P C  +    PE+   E  +L   D    F+ G    +SC+  + L G  +
Sbjct: 556  RSGRWTDSPPMCEAI--KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNN 613

Query: 2141 LHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVS-------------- 2186
            + CT  G WS   P C        +  LP   V  P     G                  
Sbjct: 614  VECTTSGRWSATPPTCKG------IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTT 667

Query: 2187 --FVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCP----NPPAILNGRHTGTPF 2240
              F C+ GF L G S   C  +G    W +  P C  + C     N P  +N  +    +
Sbjct: 668  CYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMNCSNL---W 721

Query: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
            G+  YG      C  H   G   N  G +   C    Q NG WS+  P C+         
Sbjct: 722  GNFSYGS----ICSFHCLEGQLLN--GSAQTAC----QENGHWSTTVPTCQAG------- 764

Query: 2301 PPKIQNG-HYIGGHVS 2315
            P  IQ    Y GG V+
Sbjct: 765  PLTIQEALTYFGGAVA 780



 Score =  174 bits (441), Expect = 1e-42
 Identities = 150/625 (24%), Positives = 231/625 (36%), Gaps = 104/625 (16%)

Query: 230 PQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 287
           P+C    +C    +   +L++ +  L  FS N    F C  G+ + GP +++C A   W 
Sbjct: 192 PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251

Query: 288 PELPSCSRVCQPPPDV--------LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMR 339
            + P C     PP  +        LH+ +  + + + S      +SCE G+ L G   ++
Sbjct: 252 NKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCS------FSCEEGFALVGPEVVQ 305

Query: 340 CTPQGDWSPAAPTCEVKSCDDFMGQLLNGR-VLFPVN-LQLGAKVDFVCDEGFQLKGSSA 397
           CT  G W+  AP C+   C             + P+     G+   F C  G++++G   
Sbjct: 306 CTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDM 365

Query: 398 SYCVLAGMESLWNSSVPVCEQIFC-PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDR 456
             C+ +G    W++ +P CE I C P    +         L  F +    ++ C      
Sbjct: 366 LRCIDSGH---WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC------ 416

Query: 457 GTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 516
              F L G   +RC +     G W++PAP C  L  CQ                 D P+ 
Sbjct: 417 AEGFMLRGADIVRCDN----LGQWTAPAPVCQAL-QCQ-----------------DLPVP 454

Query: 517 TSLKYECRPEY----YGRPFSITCLDNLV--------------WSSPKDVCKRKSCKTPP 558
              +  C   +    Y    S TC + L+              W+S    C+   C    
Sbjct: 455 NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514

Query: 559 DPVNGMVHVITDI---QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 615
            P NG +  +  +      S   + C  G+ L G    +C  SG    W+  PP+C+ I 
Sbjct: 515 SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEAIK 571

Query: 616 CGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGI 674
           C        G    S  R  F+ GS   + C+ G      F+L G  ++ CT++    G 
Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNNVECTTS----GR 621

Query: 675 WSGPAPQCIIPNKCTPPNVENGILVSDNRSL---------FSLNEVVEFRCQPGFVMKGP 725
           WS   P C        P V+   L +  +           F  N    F C  GF + G 
Sbjct: 622 WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGD 681

Query: 726 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDK-----DNFSPGQEVFYSCEPG 779
             + C+   +W    P+C  V C      LH  +           NFS G    + C  G
Sbjct: 682 STLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIAMNCSNLWGNFSYGSICSFHCLEG 737

Query: 780 YDLRGAASMRCTPQGDWSPAAPTCE 804
             L G+A   C   G WS   PTC+
Sbjct: 738 QLLNGSAQTACQENGHWSTTVPTCQ 762



 Score =  174 bits (441), Expect = 1e-42
 Identities = 150/625 (24%), Positives = 231/625 (36%), Gaps = 104/625 (16%)

Query: 680  PQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 737
            P+C    +C    +   +L++ +  L  FS N    F C  G+ + GP +++C A   W 
Sbjct: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251

Query: 738  PELPSCSRVCQPPPDV--------LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMR 789
             + P C     PP  +        LH+ +  + + + S      +SCE G+ L G   ++
Sbjct: 252  NKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCS------FSCEEGFALVGPEVVQ 305

Query: 790  CTPQGDWSPAAPTCEVKSCDDFMGQLLNGR-VLFPVN-LQLGAKVDFVCDEGFQLKGSSA 847
            CT  G W+  AP C+   C             + P+     G+   F C  G++++G   
Sbjct: 306  CTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDM 365

Query: 848  SYCVLAGMESLWNSSVPVCEQIFC-PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDR 906
              C+ +G    W++ +P CE I C P    +         L  F +    ++ C      
Sbjct: 366  LRCIDSGH---WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC------ 416

Query: 907  GTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966
               F L G   +RC +     G W++PAP C  L  CQ                 D P+ 
Sbjct: 417  AEGFMLRGADIVRCDN----LGQWTAPAPVCQAL-QCQ-----------------DLPVP 454

Query: 967  TSLKYECRPEY----YGRPFSITCLDNLV--------------WSSPKDVCKRKSCKTPP 1008
               +  C   +    Y    S TC + L+              W+S    C+   C    
Sbjct: 455  NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514

Query: 1009 DPVNGMVHVITDI---QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 1065
             P NG +  +  +      S   + C  G+ L G    +C  SG    W+  PP+C+ I 
Sbjct: 515  SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEAIK 571

Query: 1066 CGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGI 1124
            C        G    S  R  F+ GS   + C+ G      F+L G  ++ CT++    G 
Sbjct: 572  CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNNVECTTS----GR 621

Query: 1125 WSGPAPQCIIPNKCTPPNVENGILVSDNRSL---------FSLNEVVEFRCQPGFVMKGP 1175
            WS   P C        P V+   L +  +           F  N    F C  GF + G 
Sbjct: 622  WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGD 681

Query: 1176 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDK-----DNFSPGQEVFYSCEPG 1229
              + C+   +W    P+C  V C      LH  +           NFS G    + C  G
Sbjct: 682  STLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIAMNCSNLWGNFSYGSICSFHCLEG 737

Query: 1230 YDLRGAASMRCTPQGDWSPAAPTCE 1254
              L G+A   C   G WS   PTC+
Sbjct: 738  QLLNGSAQTACQENGHWSTTVPTCQ 762



 Score =  169 bits (429), Expect = 2e-41
 Identities = 156/601 (25%), Positives = 234/601 (38%), Gaps = 88/601 (14%)

Query: 116 HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175
           H +    F SQ  + CT GY++ G S   C+ SG   IW N+ P C    C        G
Sbjct: 215 HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271

Query: 176 DFIST-NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 233
           +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 272 NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321

Query: 234 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 293
           +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 322 VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381

Query: 294 SRV-CQPPPDVLHAERTQRDKDNFSPGQEVF-------YSCEPGYDLRGAASMRCTPQGD 345
             + C+P    +H         + SP    F       + C  G+ LRGA  +RC   G 
Sbjct: 382 EAISCEPLESPVHGSM------DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435

Query: 346 WSPAAPTCEVKSCDDF-MGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLA 403
           W+  AP C+   C D  +          P    +  +   F C+EG  L G+S   C+  
Sbjct: 436 WTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLAT 495

Query: 404 GMESLWNSSVPVCEQIFCPSPPVIP-NGRHT-GKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
           G    WNS  P C+ I C +P + P NG  T  +PL    +  T  + CD        + 
Sbjct: 496 GN---WNSVPPECQAIPC-TPLLSPQNGTMTCVQPLGSSSYKSTCQFICD------EGYS 545

Query: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD----FPIGT 517
           L G   + CT     +G W+   P C  +   + P+  LFA  +   + SD    F +G+
Sbjct: 546 LSGPERLDCTR----SGRWTDSPPMCEAI---KCPE--LFAPEQGSLDCSDTRGEFNVGS 596

Query: 518 SLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCK--------RKSCKTPPDPVNGMV--- 565
           +  + C   +    P ++ C  +  WS+    CK           C     P  G +   
Sbjct: 597 TCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656

Query: 566 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG----LPPT 621
           H        +   + C  G  LIG S+  C  SG    W+   P C+ + C       P 
Sbjct: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG---QWTAVTPACRAVKCSELHVNKPI 713

Query: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
             N    S    NF YGS+ ++ C  G        L G     C  N    G WS   P 
Sbjct: 714 AMN---CSNLWGNFSYGSICSFHCLEGQ------LLNGSAQTACQEN----GHWSTTVPT 760

Query: 682 C 682
           C
Sbjct: 761 C 761



 Score =  165 bits (417), Expect = 6e-40
 Identities = 143/578 (24%), Positives = 219/578 (37%), Gaps = 57/578 (9%)

Query: 63  FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNG---MVHVI 118
           F   +  ++ C  GY    P  + CL + +WT    +C    C     P  G    +H  
Sbjct: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279

Query: 119 KGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFI 178
           K  Q  S   +SC +G+ L+G     C  SG   +W    P+C  + C      + G   
Sbjct: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336

Query: 179 STN-RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237
             +    F YGS   + C PG      + + G   + C  +    G WS P P C   + 
Sbjct: 337 CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAIS- 385

Query: 238 CTP--PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
           C P    V   +  S +   F  +    FRC  GF+++G   V+C  L +W    P C  
Sbjct: 386 CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445

Query: 296 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
           + CQ  P    A          F       ++C  G  L GA+ ++C   G+W+   P C
Sbjct: 446 LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505

Query: 354 EVKSCDDFMGQLLNGRVLFPVNL---QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410
           +   C   +    NG +     L      +   F+CDEG+ L G     C  +G    W 
Sbjct: 506 QAIPCTPLLSP-QNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561

Query: 411 SSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR 469
            S P+CE I CP       G          F  G T +++CD        F L G + + 
Sbjct: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCD------NGFKLEGPNNVE 615

Query: 470 CTSDPQGNGVWSSPAPRC-GILG------HCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 522
           CT+    +G WS+  P C GI         C A        +  + +   F   T+  + 
Sbjct: 616 CTT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671

Query: 523 CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCK----TPPDPVNGMVHVITDIQVGSRI 577
           C   +      +++C  +  W++    C+   C       P  +N   ++  +   GS  
Sbjct: 672 CNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN-CSNLWGNFSYGSIC 730

Query: 578 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 615
           ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 731 SFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765



 Score =  158 bits (399), Expect = 7e-38
 Identities = 152/638 (23%), Positives = 235/638 (36%), Gaps = 71/638 (11%)

Query: 456  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC---QAPDHFLFAKLKTQTNASD 512
            +G   + IG  T  C     G        P C  +  C   + P H L   +       +
Sbjct: 171  QGECLETIGNYTCSCYPGFYG--------PECEYVRECGELELPQHVL---MNCSHPLGN 219

Query: 513  FPIGTSLKYECRPEYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG---MVHVI 568
            F   +   + C   Y    P  + CL + +W++    C    C     P  G    +H  
Sbjct: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279

Query: 569  TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFI 628
               Q  S  ++SC  G  L+G    +C  SG    W+   P+C+ + C      + G   
Sbjct: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASGV---WTAPAPVCKAVQCQHLEAPSEGTMD 336

Query: 629  STNREN-FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
              +    F YGS   + C PG      + + G   + C  +    G WS P P C   + 
Sbjct: 337  CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAIS- 385

Query: 688  CTPPN--VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 745
            C P    V   +  S +   F  +    FRC  GF+++G   V+C  L +W    P C  
Sbjct: 386  CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445

Query: 746  V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803
            + CQ  P    A          F       ++C  G  L GA+ ++C   G+W+   P C
Sbjct: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505

Query: 804  EVKSCDDFMGQLLNGRVLFPVNL---QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 860
            +   C   +    NG +     L      +   F+CDEG+ L G     C  +G    W 
Sbjct: 506  QAIPCTPLLSPQ-NGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561

Query: 861  SSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR 919
             S P+CE I CP       G          F  G T +++CD        F L G + + 
Sbjct: 562  DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCD------NGFKLEGPNNVE 615

Query: 920  CTSDPQGNGVWSSPAPRC-GILG------HCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 972
            CT+    +G WS+  P C GI         C A        +  + +   F   T+  + 
Sbjct: 616  CTT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671

Query: 973  CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCK----TPPDPVNGMVHVITDIQVGSRI 1027
            C   +      +++C  +  W++    C+   C       P  +N   ++  +   GS  
Sbjct: 672  CNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN-CSNLWGNFSYGSIC 730

Query: 1028 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 1065
            ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 731  SFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765



 Score =  156 bits (394), Expect = 3e-37
 Identities = 151/638 (23%), Positives = 234/638 (36%), Gaps = 71/638 (11%)

Query: 906  RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC---QAPDHFLFAKLKTQTNASD 962
            +G   + IG  T  C     G        P C  +  C   + P H L   +       +
Sbjct: 171  QGECLETIGNYTCSCYPGFYG--------PECEYVRECGELELPQHVL---MNCSHPLGN 219

Query: 963  FPIGTSLKYECRPEYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG---MVHVI 1018
            F   +   + C   Y    P  + CL + +W++    C    C     P  G    +H  
Sbjct: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279

Query: 1019 TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFI 1078
               Q  S  ++SC  G  L+G    +C  SG    W+   P+C+ + C      + G   
Sbjct: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASGV---WTAPAPVCKAVQCQHLEAPSEGTMD 336

Query: 1079 STNREN-FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +    F YGS   + C PG      + + G   + C  +    G WS P P C   + 
Sbjct: 337  CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAIS- 385

Query: 1138 CTPPN--VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 1195
            C P    V   +  S +   F  +    FRC  GF+++G   V+C  L +W    P C  
Sbjct: 386  CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445

Query: 1196 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 1253
            + CQ  P    A          F       ++C  G  L GA+ ++C   G+W+   P C
Sbjct: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505

Query: 1254 EVKSCDDFMGQLLNGRVLFPVNL---QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 1310
            +   C   +    NG +     L      +   F+CDEG+ L G     C  +G    W 
Sbjct: 506  QAIPCTPLLSPQ-NGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561

Query: 1311 SSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIR 1369
             S P+CE I CP       G          F  G   +++CD        F L G + + 
Sbjct: 562  DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCD------NGFKLEGPNNVE 615

Query: 1370 CTSDPQGNGVWSSPAPRC-GILG------HCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 1422
            CT+    +G WS+  P C GI         C A        +  + +   F   T+  + 
Sbjct: 616  CTT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671

Query: 1423 CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCK----TPPDPVNGMVHVITDIQVGSRI 1477
            C   +      +++C  +  W++    C+   C       P  +N   ++  +   GS  
Sbjct: 672  CNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN-CSNLWGNFSYGSIC 730

Query: 1478 NYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIP 1515
            ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 731  SFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765



 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 82/337 (24%), Positives = 120/337 (35%), Gaps = 42/337 (12%)

Query: 43  CNAPEWLPFARPTNLTDEFEFPIGTY-----LNYECRPGYSGRPFSII-CLKNSVWTGAK 96
           C A +      P         P G +      ++ C  G      S++ CL    W    
Sbjct: 443 CQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVP 502

Query: 97  DRCRRKSCRNPPDPVNGMVHVIKGI---QFGSQIKYSCTKGYRLIGSSSATCIISGDTVI 153
             C+   C     P NG +  ++ +    + S  ++ C +GY L G     C  SG    
Sbjct: 503 PECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR--- 559

Query: 154 WDNETPICDRIPCGLPPTITNGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 212
           W +  P+C+ I C        G    S  R  F+ GS   + C+ G      F+L G  +
Sbjct: 560 WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNN 613

Query: 213 IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---------FSLNEVVE 263
           + CT++    G WS   P C        P V+   L +  +           F  N    
Sbjct: 614 VECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCY 669

Query: 264 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDK-----DNFS 317
           F C  GF + G   + C+   +W    P+C  V C      LH  +           NFS
Sbjct: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIAMNCSNLWGNFS 725

Query: 318 PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354
            G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 726 YGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762


>gi|168693643 decay accelerating factor for complement isoform 2
           precursor [Homo sapiens]
          Length = 440

 Score =  168 bits (426), Expect = 5e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 421 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 478
           C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 479 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 534
            WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87  -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 535 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
           TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 654
           C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204 CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQC 682
           F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257 FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  168 bits (426), Expect = 5e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 871  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 928
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 929  VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 984
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1132
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  168 bits (425), Expect = 7e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 1378
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 1379 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 1434
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 1435 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1494
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 1495 CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV 1554
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1582
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  162 bits (410), Expect = 4e-39
 Identities = 80/173 (46%), Positives = 106/173 (61%), Gaps = 11/173 (6%)

Query: 63  FPIGTYLNYECRPGYSGRPF---SIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119
           FP+GT + YECRPGY   P     + CL+N  W+ A + C++KSC NP +  NG + V  
Sbjct: 119 FPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG 178

Query: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
           GI FG+ I +SC  GY+L GS+S+ C+ISG +V W +  P C  I C  PP I NG  I 
Sbjct: 179 GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQ 237

Query: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
             R+++ Y   VTY CN G      F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 238 GERDHYGYRQSVTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  155 bits (391), Expect = 6e-37
 Identities = 95/270 (35%), Positives = 131/270 (48%), Gaps = 27/270 (10%)

Query: 1771 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES-TIRCTSDPHGNGV 1829
            C  PP + N +         P    I+Y C+          + GE  ++ C         
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEES-----FVKIPGEKDSVICLKGSQ---- 86

Query: 1830 WSSPAPRCELSVRAGHCKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMF--- 1885
            WS     C  S     C+ P +   AS   P I    FPVGT + YECRPGY  +     
Sbjct: 87   WSDIEEFCNRS-----CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSP 141

Query: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945
             ++CL+NL WS+  + C++KSC  P E  NG + +     FG+T+++SCN G++L GS S
Sbjct: 142  KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTS 201

Query: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005
            + CL+SG++V W    P C  I C  PP I NG      R  +     VTY C+ G    
Sbjct: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG---- 256

Query: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035
              F ++GE SIYCT  +D+ G WS PPP C
Sbjct: 257  --FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 240 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 297
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 298 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 353
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 354 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 414 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 474 PQGNGVWSSPAPRC 487
               G WS P P C
Sbjct: 271 -NDEGEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 690 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 747
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 748 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 803
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 804 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 863
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 864 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 924 PQGNGVWSSPAPRC 937
               G WS P P C
Sbjct: 271 -NDEGEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1197
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 1198 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 1253
            + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 1254 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 1313
            + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 1314 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 1373
            P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218  PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 1374 PQGNGVWSSPAPRC 1387
                G WS P P C
Sbjct: 271  -NDEGEWSGPPPEC 283



 Score =  127 bits (320), Expect = 1e-28
 Identities = 78/253 (30%), Positives = 120/253 (47%), Gaps = 15/253 (5%)

Query: 2044 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSH--TVQCQTNGRWGPKLPHCSRVCQ 2101
            P+V NA      R+ F    +I ++C+  FV +     +V C    +W      C+R C+
Sbjct: 40   PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99

Query: 2102 PPPEILHGEHTLSH--QDNFSPGQEVFYSCEPSYDLRGAAS--LHCTPQGDWSPEAPRCT 2157
             P  +        +  Q+ F  G  V Y C P Y    + S  L C     WS     C 
Sbjct: 100  VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCK 159

Query: 2158 VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVP 2217
             KSC +  G++ +G++ +P  +  GA +SF C+ G++L G ++S C+++G    W+  +P
Sbjct: 160  KKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLP 218

Query: 2218 VCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDP 2277
             C +I+CP PP I NG   G       Y + ++YAC+        F +IGE SI CT + 
Sbjct: 219  ECREIYCPAPPQIDNGIIQGER-DHYGYRQSVTYACN------KGFTMIGEHSIYCTVN- 270

Query: 2278 QGNGVWSSPAPRC 2290
               G WS P P C
Sbjct: 271  NDEGEWSGPPPEC 283



 Score =  125 bits (313), Expect = 7e-28
 Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 15/254 (5%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1647
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 1648 QPPPEILHGEHTPSH--QDNFSPGQEVFYSCEPGYDLRGAAS--LHCTPQGDWSPEAPRC 1703
            + P  +        +  Q+ F  G  V Y C PGY    + S  L C     WS     C
Sbjct: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 1704 AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSV 1763
              KSC +  G++ +G++  P  +  GA +SF C+ G++L GS+ S C++ G    W++ +
Sbjct: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 1764 PVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSD 1823
            P C  I+CP PP I NG   G       Y + ++Y C+        F +IGE +I CT +
Sbjct: 218  PECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 1824 PHGNGVWSSPAPRC 1837
             +  G WS P P C
Sbjct: 271  -NDEGEWSGPPPEC 283



 Score =  115 bits (288), Expect = 5e-25
 Identities = 84/291 (28%), Positives = 125/291 (42%), Gaps = 30/291 (10%)

Query: 28  LAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGY---SGRPFSI 84
           L ++VLL LP  WG C  P  +P A+P  L     FP  T + Y+C   +    G   S+
Sbjct: 21  LLLLVLLCLPAVWGDCGLPPDVPNAQPA-LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79

Query: 85  ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIKG-IQFGSQIKYSCTKGYRLIGS 140
           ICLK S W+  ++ C R SC  P    +  +   ++ +     G+ ++Y C  GYR   S
Sbjct: 80  ICLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138

Query: 141 SS--ATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198
            S   TC+     + W      C +  C  P  I NG           +G+ +++ CN G
Sbjct: 139 LSPKLTCL---QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG 193

Query: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 258
                 ++L G  S +C  +   V  WS P P+C       PP ++NGI +   R  +  
Sbjct: 194 ------YKLFGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGY 245

Query: 259 NEVVEFRCQPGFVMKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 303
            + V + C  GF M G   + C   N   +W    P C   S   + PP V
Sbjct: 246 RQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score =  114 bits (284), Expect = 2e-24
 Identities = 80/278 (28%), Positives = 115/278 (41%), Gaps = 30/278 (10%)

Query: 1844 GHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVED 1900
            G C  P   P A P +      FP  T + Y+C   +    G+  S+ CL+   WS +E+
Sbjct: 34   GDCGLPPDVPNAQPALE-GRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEE 92

Query: 1901 NCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSCNEGFRLIGS--PSTTCLVSGNN 1954
             C R SC  P    +  +     TQ     G+ V Y C  G+R   S  P  TCL    N
Sbjct: 93   FCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL---QN 148

Query: 1955 VTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
            + W      C+  SC  P  I NG         F  G  +++ C+TG      ++L G  
Sbjct: 149  LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTG------YKLFGST 200

Query: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
            S +C      V  WS P P C        P+++N I + G R  +   + + + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFT 258

Query: 2075 MVGSHTVQCQTN---GRWGPKLPHC---SRVCQPPPEI 2106
            M+G H++ C  N   G W    P C   S   + PP +
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 2100 CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY-DLRGAA-SLHCTPQGDWSPEAPRCT 2157
            C  PP++ + +  L  + +F     + Y CE S+  + G   S+ C     WS     C 
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95

Query: 2158 VKSCDDFLGQLPHGRVLLPLNLQ----LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 2213
             +SC +   +L    +  P   Q    +G  V + C  G+R +  S S  +       W+
Sbjct: 96   -RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTCLQNLKWS 152

Query: 2214 SSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 2273
            ++V  C++  CPNP  I NG+    P G I +G  IS++C+T       + L G +S  C
Sbjct: 153  TAVEFCKKKSCPNPGEIRNGQ-IDVP-GGILFGATISFSCNT------GYKLFGSTSSFC 204

Query: 2274 TSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
                 G+ V WS P P C       CP PP+I NG  I G    Y    +++Y C+ G+ 
Sbjct: 205  LI--SGSSVQWSDPLPECR---EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFT 258

Query: 2333 LVGKGFIFCT---DQGIWSQLDHYCK 2355
            ++G+  I+CT   D+G WS     C+
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECR 284



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 489 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 545
           + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32  VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 546 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 601
           ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91  EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 602 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 661
             WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150 K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 662 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 721
           S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201 SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 722 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 753
           M G   + C   N   +W    P C   S   + PP V
Sbjct: 259 MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 939  ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 995
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 996  KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 1051
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 1052 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 1111
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 1112 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 1172 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 1203
            M G   + C   N   +W    P C   S   + PP V
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 74/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 1389 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 1445
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 1446 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNT 1501
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 1502 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEP 1561
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 1562 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1621
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 1622 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPEI 1653
            M G   + C   N   +W    P C   S   + PP +
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/267 (27%), Positives = 109/267 (40%), Gaps = 28/267 (10%)

Query: 1907 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGF-RLIGSPSTTCLVSGNNVTWDKKAPI 1963
            CG PP+  N    +   T F   + + Y C E F ++ G   +   + G+   W      
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93

Query: 1964 CEIISCEPPPTISNGDFYSNNRTS--FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
            C   SCE P  +++        T   F  GTVV Y+C  G   E          + C   
Sbjct: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCL-- 146

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENA-IRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
              Q   WS+    C   +     E+ N  I VPG   F      I F C  G+ + GS +
Sbjct: 147  --QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT---ISFSCNTGYKLFGSTS 201

Query: 2081 VQCQTNG---RWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
              C  +G   +W   LP C  + C  PP+I +G      +D++   Q V Y+C   + + 
Sbjct: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFTMI 260

Query: 2137 GAASLHCT---PQGDWSPEAPRCTVKS 2160
            G  S++CT    +G+WS   P C  KS
Sbjct: 261  GEHSIYCTVNNDEGEWSGPPPECRGKS 287



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 41/288 (14%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 347
           LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 397
                C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89  DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 398 SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 457
               L  ++  W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 142 KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 458 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 516
           T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192 TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 517 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 558
            S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247 QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 41/288 (14%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 797
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 847
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 848  SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 907
                L  ++  W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 142  KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 908  TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 967  TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1008
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 77/288 (26%), Positives = 120/288 (41%), Gaps = 41/288 (14%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 1247
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 1297
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 1298 SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRG 1357
                L  ++  W+++V  C++  CP+P  I NG+    P  +  FG  ++++C+      
Sbjct: 142  KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 1358 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 1416
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 1417 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1458
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 366 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 424
           L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49  LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 425 PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
             + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102 TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 482 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 538
           +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153 TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 539 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 595
            ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209 SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 596 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 622
            ++ +   WS  PP C  + +   +PPT+
Sbjct: 268 TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 816  LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 874
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 875  PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 932  SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 988
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 989  -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1045
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 1046 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 1072
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 1266 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 1324
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 1325 PVIPNGRHTGKPL---EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 1382 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 1438
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 1439 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1495
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 1496 ILSGNTAHWSTKPPIC--QRIPCGLPPTI 1522
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 64/247 (25%), Positives = 100/247 (40%), Gaps = 32/247 (12%)

Query: 2185 VSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF--- 2240
            +++ C+E F ++ G   S   L G +  W+     C +      P  LN      P+   
Sbjct: 61   ITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEFCNRSC--EVPTRLNSASLKQPYITQ 116

Query: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
               P G  + Y C     R  + +      + C      N  WS+    C+     +CP+
Sbjct: 117  NYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWSTAVEFCKKK---SCPN 165

Query: 2301 PPKIQNGHY-IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI---WSQLDHYCKE 2356
            P +I+NG   + G +   L G TIS+ C+ GY L G    FC   G    WS     C+E
Sbjct: 166  PGEIRNGQIDVPGGI---LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE 222

Query: 2357 VNC-SFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD---RWDPPL 2412
            + C + P   NGI +    +  Y Y   VT  C  G+T+ G     C  ++    W  P 
Sbjct: 223  IYCPAPPQIDNGIIQ--GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280

Query: 2413 AKCTSRT 2419
             +C  ++
Sbjct: 281  PECRGKS 287



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 74/279 (26%), Positives = 113/279 (40%), Gaps = 32/279 (11%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-DLRGAA-SLHCTPQGDWS 1697
            LP+    C  PP++ + +     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ----LGAKVSFVCDEGFRLKGSSVSHCVLV 1753
                 C  +SC +   +L    +  P   Q    +G  V + C  G+R +  S+S  +  
Sbjct: 89   DIEEFCN-RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTC 145

Query: 1754 GMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLI 1813
                 W+ +V  C+   CPNP  I NG+    P G I +G  IS++C+        + L 
Sbjct: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGG-ILFGATISFSCN------TGYKLF 197

Query: 1814 GESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSL 1872
            G ++  C     G+ V WS P P C    R  +C  P Q    +  I      +    S+
Sbjct: 198  GSTSSFCLIS--GSSVQWSDPLPEC----REIYCPAPPQID--NGIIQGERDHYGYRQSV 249

Query: 1873 NYECRPGY--FGKMFSISCLENL---VWSSVEDNCRRKS 1906
             Y C  G+   G+  SI C  N     WS     CR KS
Sbjct: 250  TYACNKGFTMIGE-HSIYCTVNNDEGEWSGPPPECRGKS 287


>gi|10835143 decay accelerating factor for complement isoform 1
           preproprotein [Homo sapiens]
          Length = 381

 Score =  168 bits (426), Expect = 5e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 421 CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 478
           C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 479 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 534
            WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87  -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 535 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
           TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 654
           C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204 CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQC 682
           F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257 FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  168 bits (426), Expect = 5e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 871  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 928
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 929  VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 984
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 985  TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1132
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  168 bits (425), Expect = 7e-41
 Identities = 101/268 (37%), Positives = 139/268 (51%), Gaps = 26/268 (9%)

Query: 1321 CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI-GES-TIRCTSDPQGNG 1378
            C  PP +PN +   +    FP    + Y C+       SF  I GE  ++ C    Q   
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEE------SFVKIPGEKDSVICLKGSQ--- 86

Query: 1379 VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPF---SI 1434
             WS     C     C+ P     A LK      + FP+GT ++YECRP Y   P     +
Sbjct: 87   -WSDIEEFCN--RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKL 143

Query: 1435 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1494
            TCL NL WS+  + CK+KSC  P +  NG + V   I  G+ I++SC TG++L G +S+ 
Sbjct: 144  TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSF 203

Query: 1495 CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV 1554
            C++SG++  WS   P C+ I C  PP I NG  I   R+++ Y   VTY CN G      
Sbjct: 204  CLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG------ 256

Query: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQC 1582
            F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 257  FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  162 bits (410), Expect = 4e-39
 Identities = 80/173 (46%), Positives = 106/173 (61%), Gaps = 11/173 (6%)

Query: 63  FPIGTYLNYECRPGYSGRPF---SIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119
           FP+GT + YECRPGY   P     + CL+N  W+ A + C++KSC NP +  NG + V  
Sbjct: 119 FPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG 178

Query: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
           GI FG+ I +SC  GY+L GS+S+ C+ISG +V W +  P C  I C  PP I NG  I 
Sbjct: 179 GILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQ 237

Query: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
             R+++ Y   VTY CN G      F ++GE SIYCT N+D+ G WSGP P+C
Sbjct: 238 GERDHYGYRQSVTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  155 bits (391), Expect = 6e-37
 Identities = 95/270 (35%), Positives = 131/270 (48%), Gaps = 27/270 (10%)

Query: 1771 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES-TIRCTSDPHGNGV 1829
            C  PP + N +         P    I+Y C+          + GE  ++ C         
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEES-----FVKIPGEKDSVICLKGSQ---- 86

Query: 1830 WSSPAPRCELSVRAGHCKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMF--- 1885
            WS     C  S     C+ P +   AS   P I    FPVGT + YECRPGY  +     
Sbjct: 87   WSDIEEFCNRS-----CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSP 141

Query: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945
             ++CL+NL WS+  + C++KSC  P E  NG + +     FG+T+++SCN G++L GS S
Sbjct: 142  KLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTS 201

Query: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005
            + CL+SG++V W    P C  I C  PP I NG      R  +     VTY C+ G    
Sbjct: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG---- 256

Query: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035
              F ++GE SIYCT  +D+ G WS PPP C
Sbjct: 257  --FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 240 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 297
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 298 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 353
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 354 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 414 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 474 PQGNGVWSSPAPRC 487
               G WS P P C
Sbjct: 271 -NDEGEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 690 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 747
           PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39  PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 748 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 803
           + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99  EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 804 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 863
           + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159 KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 864 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923
           P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218 PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 924 PQGNGVWSSPAPRC 937
               G WS P P C
Sbjct: 271 -NDEGEWSGPPPEC 283



 Score =  136 bits (342), Expect = 3e-31
 Identities = 80/254 (31%), Positives = 131/254 (51%), Gaps = 15/254 (5%)

Query: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1197
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 1198 QPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGAAS--MRCTPQGDWSPAAPTC 1253
            + P  +  A   Q    ++ F  G  V Y C PGY    + S  + C     WS A   C
Sbjct: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 1254 EVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 1313
            + KSC +  G++ NG++  P  +  GA + F C+ G++L GS++S+C+++G    W+  +
Sbjct: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 1314 PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 1373
            P C +I+CP+PP I NG   G+  + + + ++V Y C+        F +IGE +I CT +
Sbjct: 218  PECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 1374 PQGNGVWSSPAPRC 1387
                G WS P P C
Sbjct: 271  -NDEGEWSGPPPEC 283



 Score =  127 bits (320), Expect = 1e-28
 Identities = 78/253 (30%), Positives = 120/253 (47%), Gaps = 15/253 (5%)

Query: 2044 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSH--TVQCQTNGRWGPKLPHCSRVCQ 2101
            P+V NA      R+ F    +I ++C+  FV +     +V C    +W      C+R C+
Sbjct: 40   PDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCE 99

Query: 2102 PPPEILHGEHTLSH--QDNFSPGQEVFYSCEPSYDLRGAAS--LHCTPQGDWSPEAPRCT 2157
             P  +        +  Q+ F  G  V Y C P Y    + S  L C     WS     C 
Sbjct: 100  VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCK 159

Query: 2158 VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVP 2217
             KSC +  G++ +G++ +P  +  GA +SF C+ G++L G ++S C+++G    W+  +P
Sbjct: 160  KKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLP 218

Query: 2218 VCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDP 2277
             C +I+CP PP I NG   G       Y + ++YAC+        F +IGE SI CT + 
Sbjct: 219  ECREIYCPAPPQIDNGIIQGER-DHYGYRQSVTYACN------KGFTMIGEHSIYCTVN- 270

Query: 2278 QGNGVWSSPAPRC 2290
               G WS P P C
Sbjct: 271  NDEGEWSGPPPEC 283



 Score =  125 bits (313), Expect = 7e-28
 Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 15/254 (5%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV-MKGPR-RVKCQALNKWEPELPSCSRVC 1647
            PP+V N     + R+ F  + V+ ++C+  FV + G +  V C   ++W      C+R C
Sbjct: 39   PPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSC 98

Query: 1648 QPPPEILHGEHTPSH--QDNFSPGQEVFYSCEPGYDLRGAAS--LHCTPQGDWSPEAPRC 1703
            + P  +        +  Q+ F  G  V Y C PGY    + S  L C     WS     C
Sbjct: 99   EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFC 158

Query: 1704 AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSV 1763
              KSC +  G++ +G++  P  +  GA +SF C+ G++L GS+ S C++ G    W++ +
Sbjct: 159  KKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217

Query: 1764 PVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSD 1823
            P C  I+CP PP I NG   G       Y + ++Y C+        F +IGE +I CT +
Sbjct: 218  PECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGFTMIGEHSIYCTVN 270

Query: 1824 PHGNGVWSSPAPRC 1837
             +  G WS P P C
Sbjct: 271  -NDEGEWSGPPPEC 283



 Score =  115 bits (288), Expect = 5e-25
 Identities = 84/291 (28%), Positives = 125/291 (42%), Gaps = 30/291 (10%)

Query: 28  LAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGY---SGRPFSI 84
           L ++VLL LP  WG C  P  +P A+P  L     FP  T + Y+C   +    G   S+
Sbjct: 21  LLLLVLLCLPAVWGDCGLPPDVPNAQPA-LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79

Query: 85  ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIKG-IQFGSQIKYSCTKGYRLIGS 140
           ICLK S W+  ++ C R SC  P    +  +   ++ +     G+ ++Y C  GYR   S
Sbjct: 80  ICLKGSQWSDIEEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138

Query: 141 SS--ATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198
            S   TC+     + W      C +  C  P  I NG           +G+ +++ CN G
Sbjct: 139 LSPKLTCL---QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG 193

Query: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 258
                 ++L G  S +C  +   V  WS P P+C       PP ++NGI +   R  +  
Sbjct: 194 ------YKLFGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGY 245

Query: 259 NEVVEFRCQPGFVMKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 303
            + V + C  GF M G   + C   N   +W    P C   S   + PP V
Sbjct: 246 RQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score =  114 bits (284), Expect = 2e-24
 Identities = 80/278 (28%), Positives = 115/278 (41%), Gaps = 30/278 (10%)

Query: 1844 GHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVED 1900
            G C  P   P A P +      FP  T + Y+C   +    G+  S+ CL+   WS +E+
Sbjct: 34   GDCGLPPDVPNAQPALE-GRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEE 92

Query: 1901 NCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSCNEGFRLIGS--PSTTCLVSGNN 1954
             C R SC  P    +  +     TQ     G+ V Y C  G+R   S  P  TCL    N
Sbjct: 93   FCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCL---QN 148

Query: 1955 VTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
            + W      C+  SC  P  I NG         F  G  +++ C+TG      ++L G  
Sbjct: 149  LKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILF--GATISFSCNTG------YKLFGST 200

Query: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
            S +C      V  WS P P C        P+++N I + G R  +   + + + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFT 258

Query: 2075 MVGSHTVQCQTN---GRWGPKLPHC---SRVCQPPPEI 2106
            M+G H++ C  N   G W    P C   S   + PP +
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 27/266 (10%)

Query: 2100 CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY-DLRGAA-SLHCTPQGDWSPEAPRCT 2157
            C  PP++ + +  L  + +F     + Y CE S+  + G   S+ C     WS     C 
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95

Query: 2158 VKSCDDFLGQLPHGRVLLPLNLQ----LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 2213
             +SC +   +L    +  P   Q    +G  V + C  G+R +  S S  +       W+
Sbjct: 96   -RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTCLQNLKWS 152

Query: 2214 SSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 2273
            ++V  C++  CPNP  I NG+    P G I +G  IS++C+T       + L G +S  C
Sbjct: 153  TAVEFCKKKSCPNPGEIRNGQ-IDVP-GGILFGATISFSCNT------GYKLFGSTSSFC 204

Query: 2274 TSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
                 G+ V WS P P C       CP PP+I NG  I G    Y    +++Y C+ G+ 
Sbjct: 205  LI--SGSSVQWSDPLPECR---EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFT 258

Query: 2333 LVGKGFIFCT---DQGIWSQLDHYCK 2355
            ++G+  I+CT   D+G WS     C+
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECR 284



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 489 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 545
           + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32  VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 546 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 601
           ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91  EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 602 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 661
             WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150 K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 662 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 721
           S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201 SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 722 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 753
           M G   + C   N   +W    P C   S   + PP V
Sbjct: 259 MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 939  ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 995
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 996  KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNA 1051
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 1052 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEP 1111
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 1112 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 1172 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPDV 1203
            M G   + C   N   +W    P C   S   + PP V
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 74/278 (26%), Positives = 113/278 (40%), Gaps = 26/278 (9%)

Query: 1389 ILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSITCLDNLVWSSP 1445
            + G C  P     A+   +   S FP  T + Y+C   +    G   S+ CL    WS  
Sbjct: 32   VWGDCGLPPDVPNAQPALEGRTS-FPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI 90

Query: 1446 KDVCKRKSCKTPPDPVNGMVH--VITD--IQVGSRINYSCTTGHRLIGHSSAECILSGNT 1501
            ++ C R SC+ P    +  +    IT     VG+ + Y C  G+R     S +     N 
Sbjct: 91   EEFCNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNL 149

Query: 1502 AHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEP 1561
              WST    C++  C  P  I NG           +G+ +++ CN G      ++L G  
Sbjct: 150  K-WSTAVEFCKKKSCPNPGEIRNGQIDVPG--GILFGATISFSCNTG------YKLFGST 200

Query: 1562 SIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1621
            S +C  +   V  WS P P+C       PP ++NGI+  + R  +   + V + C  GF 
Sbjct: 201  SSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGE-RDHYGYRQSVTYACNKGFT 258

Query: 1622 MKGPRRVKCQALN---KWEPELPSC---SRVCQPPPEI 1653
            M G   + C   N   +W    P C   S   + PP +
Sbjct: 259  MIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/267 (27%), Positives = 109/267 (40%), Gaps = 28/267 (10%)

Query: 1907 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGF-RLIGSPSTTCLVSGNNVTWDKKAPI 1963
            CG PP+  N    +   T F   + + Y C E F ++ G   +   + G+   W      
Sbjct: 36   CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93

Query: 1964 CEIISCEPPPTISNGDFYSNNRTS--FHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
            C   SCE P  +++        T   F  GTVV Y+C  G   E          + C   
Sbjct: 94   CNR-SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCL-- 146

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENA-IRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
              Q   WS+    C   +     E+ N  I VPG   F      I F C  G+ + GS +
Sbjct: 147  --QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT---ISFSCNTGYKLFGSTS 201

Query: 2081 VQCQTNG---RWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
              C  +G   +W   LP C  + C  PP+I +G      +D++   Q V Y+C   + + 
Sbjct: 202  SFCLISGSSVQWSDPLPECREIYCPAPPQIDNGI-IQGERDHYGYRQSVTYACNKGFTMI 260

Query: 2137 GAASLHCT---PQGDWSPEAPRCTVKS 2160
            G  S++CT    +G+WS   P C  KS
Sbjct: 261  GEHSIYCTVNNDEGEWSGPPPECRGKS 287



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 41/288 (14%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 347
           LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29  LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 397
                C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89  DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 398 SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 457
               L  ++  W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 142 KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 458 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 516
           T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192 TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 517 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 558
            S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247 QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 41/288 (14%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 797
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 847
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 848  SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRG 907
                L  ++  W+++V  C++  CP+P  I NG+    P  +  FG T++++C+      
Sbjct: 142  KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 908  TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 966
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 967  TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1008
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 77/288 (26%), Positives = 120/288 (41%), Gaps = 41/288 (14%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGAA-SMRCTPQGDWS 1247
            LP+    C  PPDV +A+     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVL---------FPVNLQLGAKVDFVCDEGFQLKGS-SA 1297
                 C  +SC+  +   LN   L         FPV    G  V++ C  G++ + S S 
Sbjct: 89   DIEEFCN-RSCE--VPTRLNSASLKQPYITQNYFPV----GTVVEYECRPGYRREPSLSP 141

Query: 1298 SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRG 1357
                L  ++  W+++V  C++  CP+P  I NG+    P  +  FG  ++++C+      
Sbjct: 142  KLTCLQNLK--WSTAVEFCKKKSCPNPGEIRNGQ-IDVPGGIL-FGATISFSCN------ 191

Query: 1358 TSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIG 1416
            T + L G ++  C     G+ V WS P P C  + +C AP       +  Q     +   
Sbjct: 192  TGYKLFGSTSSFCLI--SGSSVQWSDPLPECREI-YCPAPPQIDNGII--QGERDHYGYR 246

Query: 1417 TSLKYECRPEY-YGRPFSITCL---DNLVWSSPKDVCKRKS--CKTPP 1458
             S+ Y C   +      SI C    D   WS P   C+ KS   K PP
Sbjct: 247  QSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPP 294



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 366 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 424
           L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49  LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 425 PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
             + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102 TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 482 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 538
           +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153 TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 539 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 595
            ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209 SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 596 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 622
            ++ +   WS  PP C  + +   +PPT+
Sbjct: 268 TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 816  LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 874
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 875  PVIPNGRHTGKPL---EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 932  SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 988
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 989  -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1045
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 1046 ILSGNAAHWSTKPPIC--QRIPCGLPPTI 1072
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 67/269 (24%), Positives = 101/269 (37%), Gaps = 33/269 (12%)

Query: 1266 LNGRVLFPVNLQLGAKVDFVCDEGF-QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSP 1324
            L GR  FP +      + + C+E F ++ G   S   L G  S W+     C +  C  P
Sbjct: 49   LEGRTSFPED----TVITYKCEESFVKIPGEKDSVICLKG--SQWSDIEEFCNRS-CEVP 101

Query: 1325 PVIPNGRHTGKPL---EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
              + N     +P      FP G  V Y C P   R  S        + C      N  WS
Sbjct: 102  TRL-NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWS 152

Query: 1382 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLD- 1438
            +    C     C  P      ++           G ++ + C   Y  +G   S   +  
Sbjct: 153  TAVEFCKKKS-CPNPGEIRNGQIDVP---GGILFGATISFSCNTGYKLFGSTSSFCLISG 208

Query: 1439 -NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSR--INYSCTTGHRLIGHSSAEC 1495
             ++ WS P   C+   C  PP   NG++    D   G R  + Y+C  G  +IG  S  C
Sbjct: 209  SSVQWSDPLPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYC 267

Query: 1496 ILSGNTAHWSTKPPIC--QRIPCGLPPTI 1522
             ++ +   WS  PP C  + +   +PPT+
Sbjct: 268  TVNNDEGEWSGPPPECRGKSLTSKVPPTV 296



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 64/247 (25%), Positives = 100/247 (40%), Gaps = 32/247 (12%)

Query: 2185 VSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF--- 2240
            +++ C+E F ++ G   S   L G +  W+     C +      P  LN      P+   
Sbjct: 61   ITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEFCNRSC--EVPTRLNSASLKQPYITQ 116

Query: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
               P G  + Y C     R  + +      + C      N  WS+    C+     +CP+
Sbjct: 117  NYFPVGTVVEYECRPGYRREPSLS----PKLTCLQ----NLKWSTAVEFCKKK---SCPN 165

Query: 2301 PPKIQNGHY-IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI---WSQLDHYCKE 2356
            P +I+NG   + G +   L G TIS+ C+ GY L G    FC   G    WS     C+E
Sbjct: 166  PGEIRNGQIDVPGGI---LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRE 222

Query: 2357 VNC-SFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD---RWDPPL 2412
            + C + P   NGI +    +  Y Y   VT  C  G+T+ G     C  ++    W  P 
Sbjct: 223  IYCPAPPQIDNGIIQ--GERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280

Query: 2413 AKCTSRT 2419
             +C  ++
Sbjct: 281  PECRGKS 287



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 74/279 (26%), Positives = 113/279 (40%), Gaps = 32/279 (11%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-DLRGAA-SLHCTPQGDWS 1697
            LP+    C  PP++ + +     + +F     + Y CE  +  + G   S+ C     WS
Sbjct: 29   LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ----LGAKVSFVCDEGFRLKGSSVSHCVLV 1753
                 C  +SC +   +L    +  P   Q    +G  V + C  G+R +  S+S  +  
Sbjct: 89   DIEEFCN-RSC-EVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR-REPSLSPKLTC 145

Query: 1754 GMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLI 1813
                 W+ +V  C+   CPNP  I NG+    P G I +G  IS++C+        + L 
Sbjct: 146  LQNLKWSTAVEFCKKKSCPNPGEIRNGQ-IDVPGG-ILFGATISFSCN------TGYKLF 197

Query: 1814 GESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSL 1872
            G ++  C     G+ V WS P P C    R  +C  P Q    +  I      +    S+
Sbjct: 198  GSTSSFCLIS--GSSVQWSDPLPEC----REIYCPAPPQID--NGIIQGERDHYGYRQSV 249

Query: 1873 NYECRPGY--FGKMFSISCLENL---VWSSVEDNCRRKS 1906
             Y C  G+   G+  SI C  N     WS     CR KS
Sbjct: 250  TYACNKGFTMIGE-HSIYCTVNNDEGEWSGPPPECRGKS 287


>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
           precursor [Homo sapiens]
          Length = 378

 Score =  159 bits (402), Expect = 3e-38
 Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
             V F C  GF + G   + C + + W+P +P C +V  P    PP + H+  T
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score =  154 bits (389), Expect = 1e-36
 Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 2101 QP----PPEILHGEHTLS 2114
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 748 QP----PPDVLHAERT 759
            P    PP + H+  T
Sbjct: 288 PPSSTKPPALSHSVST 303



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1198 QP----PPDVLHAERT 1209
             P    PP + H+  T
Sbjct: 288  PPSSTKPPALSHSVST 303



 Score =  149 bits (377), Expect = 3e-35
 Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1648 QP----PPEILHGEHTPS 1661
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  130 bits (327), Expect = 2e-29
 Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVC 1449
             +Y     +I C  N  W  P   C
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  122 bits (306), Expect = 4e-27
 Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEV 2357
            L G   I C     W      C +V
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  114 bits (286), Expect = 9e-25
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1902
            +EC  G Y     +I C  N  W      C
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 83/314 (26%), Positives = 128/314 (40%), Gaps = 37/314 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISY 1798
            L GS    C      S W+  VP C  +  P+   PPA+ +   T + +   P      Y
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKS-PASSASGY 317

Query: 1799 TCDPHPDRGMTFNL 1812
               P P+ G+  +L
Sbjct: 318  ---PKPEEGILDSL 328



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 81/309 (26%), Positives = 123/309 (39%), Gaps = 37/309 (11%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKAVNY 1348
            L GS    C      S W+  VP C ++  PS   PP + +   T    +  P   A  Y
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 1349 TCDPHPDRG 1357
               P P+ G
Sbjct: 318  ---PKPEEG 323



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 80/309 (25%), Positives = 121/309 (39%), Gaps = 37/309 (11%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 448
           L GS    C      S W+  VP C ++  PS   PP + +   T    +  P      Y
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 449 TCDPHPDRG 457
              P P+ G
Sbjct: 318 ---PKPEEG 323



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 80/309 (25%), Positives = 122/309 (39%), Gaps = 37/309 (11%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 898
           L GS    C      S W+  VP C ++  PS   PP + +   T    +  P      Y
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 899 TCDPHPDRG 907
              P P+ G
Sbjct: 318 ---PKPEEG 323



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 33/285 (11%)

Query: 2038 TNKCTAPEVENAIRVPGN-RSFFTLTEIIRFRCQPGFVMV---GSHTVQCQTNGRWGPKL 2093
            ++ C  P    A+ + G  + ++ + E + ++C+ G+  +    +HT+ C  N  W P  
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVS 90

Query: 2094 PH-CSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD--- 2148
               C R  C    + L+G+  +     +  G ++ + C   Y L G   L+C  +G    
Sbjct: 91   DDACYRETCPYIRDPLNGQ-AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149

Query: 2149 WSPEAPRCTVKSCDD--FLGQLPHGRVLLPLNLQLGAKVSFVCD-----EGFRLKGRSAS 2201
            WS + P C    C     +    H    + +   L A V++ CD     + F L G S  
Sbjct: 150  WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTI 208

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 2261
            +C   G  ++W+ + P C+ + C   P + NG+          +GK+  Y      +   
Sbjct: 209  YC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMFECDK 258

Query: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
             F L G  +I C S    N  W  P P+C   +P +   PP + +
Sbjct: 259  GFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299


>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
           precursor [Homo sapiens]
          Length = 392

 Score =  159 bits (402), Expect = 3e-38
 Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
             V F C  GF + G   + C + + W+P +P C +V  P    PP + H+  T
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score =  154 bits (389), Expect = 1e-36
 Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 2101 QP----PPEILHGEHTLS 2114
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 748 QP----PPDVLHAERT 759
            P    PP + H+  T
Sbjct: 288 PPSSTKPPALSHSVST 303



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1198 QP----PPDVLHAERT 1209
             P    PP + H+  T
Sbjct: 288  PPSSTKPPALSHSVST 303



 Score =  149 bits (377), Expect = 3e-35
 Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1648 QP----PPEILHGEHTPS 1661
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  130 bits (327), Expect = 2e-29
 Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVC 1449
             +Y     +I C  N  W  P   C
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  122 bits (306), Expect = 4e-27
 Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEV 2357
            L G   I C     W      C +V
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  114 bits (286), Expect = 9e-25
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1902
            +EC  G Y     +I C  N  W      C
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 87/324 (26%), Positives = 132/324 (40%), Gaps = 43/324 (13%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHT--------GTPSGDI 1790
            L GS    C      S W+  VP C  +  P+   PPA+ +   T         + SG  
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPR 318

Query: 1791 P-YGKEIS-YTCDPHPDRGMTFNL 1812
            P Y   +S Y   P P+ G+  +L
Sbjct: 319  PTYKPPVSNYPGYPKPEEGILDSL 342



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 114/285 (40%), Gaps = 33/285 (11%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 433
           L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 115/285 (40%), Gaps = 33/285 (11%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 883
           L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 115/285 (40%), Gaps = 33/285 (11%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 1333
            L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 33/285 (11%)

Query: 2038 TNKCTAPEVENAIRVPGN-RSFFTLTEIIRFRCQPGFVMV---GSHTVQCQTNGRWGPKL 2093
            ++ C  P    A+ + G  + ++ + E + ++C+ G+  +    +HT+ C  N  W P  
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVS 90

Query: 2094 PH-CSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD--- 2148
               C R  C    + L+G+  +     +  G ++ + C   Y L G   L+C  +G    
Sbjct: 91   DDACYRETCPYIRDPLNGQ-AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149

Query: 2149 WSPEAPRCTVKSCDD--FLGQLPHGRVLLPLNLQLGAKVSFVCD-----EGFRLKGRSAS 2201
            WS + P C    C     +    H    + +   L A V++ CD     + F L G S  
Sbjct: 150  WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTI 208

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 2261
            +C   G  ++W+ + P C+ + C   P + NG+          +GK+  Y      +   
Sbjct: 209  YC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMFECDK 258

Query: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
             F L G  +I C S    N  W  P P+C   +P +   PP + +
Sbjct: 259  GFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299


>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
           precursor [Homo sapiens]
          Length = 385

 Score =  159 bits (402), Expect = 3e-38
 Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
             V F C  GF + G   + C + + W+P +P C +V  P    PP + H+  T
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score =  154 bits (389), Expect = 1e-36
 Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 2101 QP----PPEILHGEHTLS 2114
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 748 QP----PPDVLHAERT 759
            P    PP + H+  T
Sbjct: 288 PPSSTKPPALSHSVST 303



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1198 QP----PPDVLHAERT 1209
             P    PP + H+  T
Sbjct: 288  PPSSTKPPALSHSVST 303



 Score =  149 bits (377), Expect = 3e-35
 Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1648 QP----PPEILHGEHTPS 1661
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  130 bits (327), Expect = 2e-29
 Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVC 1449
             +Y     +I C  N  W  P   C
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  122 bits (306), Expect = 4e-27
 Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEV 2357
            L G   I C     W      C +V
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  114 bits (286), Expect = 9e-25
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1902
            +EC  G Y     +I C  N  W      C
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 83/314 (26%), Positives = 128/314 (40%), Gaps = 37/314 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISY 1798
            L GS    C      S W+  VP C  +  P+   PPA+ +   T + +   P      Y
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKS-PASSASGY 317

Query: 1799 TCDPHPDRGMTFNL 1812
               P P+ G+  +L
Sbjct: 318  ---PKPEEGILDSL 328



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 81/309 (26%), Positives = 123/309 (39%), Gaps = 37/309 (11%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKAVNY 1348
            L GS    C      S W+  VP C ++  PS   PP + +   T    +  P   A  Y
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 1349 TCDPHPDRG 1357
               P P+ G
Sbjct: 318  ---PKPEEG 323



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 80/309 (25%), Positives = 121/309 (39%), Gaps = 37/309 (11%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 448
           L GS    C      S W+  VP C ++  PS   PP + +   T    +  P      Y
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 449 TCDPHPDRG 457
              P P+ G
Sbjct: 318 ---PKPEEG 323



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 80/309 (25%), Positives = 122/309 (39%), Gaps = 37/309 (11%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 898
           L GS    C      S W+  VP C ++  PS   PP + +   T    +  P      Y
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317

Query: 899 TCDPHPDRG 907
              P P+ G
Sbjct: 318 ---PKPEEG 323



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 33/285 (11%)

Query: 2038 TNKCTAPEVENAIRVPGN-RSFFTLTEIIRFRCQPGFVMV---GSHTVQCQTNGRWGPKL 2093
            ++ C  P    A+ + G  + ++ + E + ++C+ G+  +    +HT+ C  N  W P  
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVS 90

Query: 2094 PH-CSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD--- 2148
               C R  C    + L+G+  +     +  G ++ + C   Y L G   L+C  +G    
Sbjct: 91   DDACYRETCPYIRDPLNGQ-AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149

Query: 2149 WSPEAPRCTVKSCDD--FLGQLPHGRVLLPLNLQLGAKVSFVCD-----EGFRLKGRSAS 2201
            WS + P C    C     +    H    + +   L A V++ CD     + F L G S  
Sbjct: 150  WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTI 208

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 2261
            +C   G  ++W+ + P C+ + C   P + NG+          +GK+  Y      +   
Sbjct: 209  YC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMFECDK 258

Query: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
             F L G  +I C S    N  W  P P+C   +P +   PP + +
Sbjct: 259  GFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299


>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
           precursor [Homo sapiens]
          Length = 399

 Score =  159 bits (402), Expect = 3e-38
 Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
             V F C  GF + G   + C + + W+P +P C +V  P    PP + H+  T
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score =  154 bits (389), Expect = 1e-36
 Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 2101 QP----PPEILHGEHTLS 2114
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 748 QP----PPDVLHAERT 759
            P    PP + H+  T
Sbjct: 288 PPSSTKPPALSHSVST 303



 Score =  151 bits (382), Expect = 7e-36
 Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1198 QP----PPDVLHAERT 1209
             P    PP + H+  T
Sbjct: 288  PPSSTKPPALSHSVST 303



 Score =  149 bits (377), Expect = 3e-35
 Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V 
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287

Query: 1648 QP----PPEILHGEHTPS 1661
             P    PP + H   T S
Sbjct: 288  PPSSTKPPALSHSVSTSS 305



 Score =  130 bits (327), Expect = 2e-29
 Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVC 1449
             +Y     +I C  N  W  P   C
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  129 bits (323), Expect = 5e-29
 Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)

Query: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
            +Y     +I C  N  W  P   C
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  122 bits (306), Expect = 4e-27
 Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEV 2357
            L G   I C     W      C +V
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  114 bits (286), Expect = 9e-25
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1902
            +EC  G Y     +I C  N  W      C
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 87/324 (26%), Positives = 132/324 (40%), Gaps = 43/324 (13%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHT--------GTPSGDI 1790
            L GS    C      S W+  VP C  +  P+   PPA+ +   T         + SG  
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPR 318

Query: 1791 P-YGKEIS-YTCDPHPDRGMTFNL 1812
            P Y   +S Y   P P+ G+  +L
Sbjct: 319  PTYKPPVSNYPGYPKPEEGILDSL 342



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 114/285 (40%), Gaps = 33/285 (11%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 433
           L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 115/285 (40%), Gaps = 33/285 (11%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 883
           L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 75/285 (26%), Positives = 115/285 (40%), Gaps = 33/285 (11%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHT 1333
            L GS    C      S W+  VP C ++  PS   PP + +   T
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 33/285 (11%)

Query: 2038 TNKCTAPEVENAIRVPGN-RSFFTLTEIIRFRCQPGFVMV---GSHTVQCQTNGRWGPKL 2093
            ++ C  P    A+ + G  + ++ + E + ++C+ G+  +    +HT+ C  N  W P  
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVS 90

Query: 2094 PH-CSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD--- 2148
               C R  C    + L+G+  +     +  G ++ + C   Y L G   L+C  +G    
Sbjct: 91   DDACYRETCPYIRDPLNGQ-AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149

Query: 2149 WSPEAPRCTVKSCDD--FLGQLPHGRVLLPLNLQLGAKVSFVCD-----EGFRLKGRSAS 2201
            WS + P C    C     +    H    + +   L A V++ CD     + F L G S  
Sbjct: 150  WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTI 208

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 2261
            +C   G  ++W+ + P C+ + C   P + NG+          +GK+  Y      +   
Sbjct: 209  YC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMFECDK 258

Query: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
             F L G  +I C S    N  W  P P+C   +P +   PP + +
Sbjct: 259  GFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299


>gi|187960042 selectin E precursor [Homo sapiens]
          Length = 610

 Score =  155 bits (391), Expect = 6e-37
 Identities = 122/446 (27%), Positives = 182/446 (40%), Gaps = 48/446 (10%)

Query: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1858
            +C  H +   T N        C  DP  +G+      +CE  V     ++PE       +
Sbjct: 147  SCSGHGECVETIN-----NYTCKCDPGFSGL------KCEQIVNCTALESPEHGSLVC-S 194

Query: 1859 IPINDFEFPVGTSLNYECRPGYF-GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1917
             P+ +F +   +S +  C  GY    M ++ C+ +  WS+    C    C     P NG 
Sbjct: 195  HPLGNFSY--NSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGF 252

Query: 1918 VHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPT 1974
            V    +     + +T  + C EGF L+G+ S  C  SGN   WD + P C+ ++C     
Sbjct: 253  VECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQ 309

Query: 1975 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 2034
              NG      R S       T++       E+ F L G   + CT++    G W+   P 
Sbjct: 310  PQNGSV----RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ----GQWTQQIPV 361

Query: 2035 CISTNKCTA---PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
            C    +CTA   PE      +P     F       F C+ GFV+ GS  +QC   G W  
Sbjct: 362  C-EAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420

Query: 2092 KLP-----HCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQ 2146
            + P      C  V QPP  ++   H  S    F+      +SCE  ++L G+  L CT Q
Sbjct: 421  EKPTCEAVRCDAVHQPPKGLVRCAH--SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQ 478

Query: 2147 GDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQ--LGAKVSFVCDEGFRLKGRSASHCV 2204
            G W+ E P C V  C      +P G++ +  + +   G    F C EG+ L G +A  C 
Sbjct: 479  GQWTEEVPSCQVVKCSSL--AVP-GKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC- 534

Query: 2205 LAGMKALWNSSVPVCEQIFCPNPPAI 2230
              G    W+  +P CE     N P +
Sbjct: 535  --GATGHWSGLLPTCEAPTESNIPLV 558



 Score =  141 bits (355), Expect = 9e-33
 Identities = 109/400 (27%), Positives = 165/400 (41%), Gaps = 44/400 (11%)

Query: 1453 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1509
            +C     P +G +   H + +    S  + SC  G+      + +C+ SG    WS   P
Sbjct: 179  NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235

Query: 1510 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
             C  + C      ANG F+    N  +F + +  T+ C  G      FEL+G  S+ CTS
Sbjct: 236  ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288

Query: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1625
            +    G W    P C           +NG +   +     F+      F C+ GF+++GP
Sbjct: 289  S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344

Query: 1626 RRVKCQALNKWEPELPSCSR---VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDL 1682
             +V+C    +W  ++P C          PE  +    PS   +F  G    +SCE G+ L
Sbjct: 345  AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404

Query: 1683 RGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL---FPL-NLQLGAKVSFVCDE 1738
            +G+  L C P G+W  E P C    C D + Q P G V     P+      +  +F C+E
Sbjct: 405  KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463

Query: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
            GF L GS+   C   G    W   VP C+ + C +    + G+   + SG+  +G    +
Sbjct: 464  GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSS--LAVPGKINMSCSGEPVFGTVCKF 518

Query: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCE 1838
             C      G T N  G +   C +  H    WS   P CE
Sbjct: 519  AC----PEGWTLN--GSAARTCGATGH----WSGLLPTCE 548



 Score =  135 bits (339), Expect = 7e-31
 Identities = 118/450 (26%), Positives = 180/450 (40%), Gaps = 72/450 (16%)

Query: 65  IGTYLNYECR--PGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIK 119
           + T  NY C+  PG+SG     I                 +C     P +G +   H + 
Sbjct: 155 VETINNYTCKCDPGFSGLKCEQIV----------------NCTALESPEHGSLVCSHPLG 198

Query: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
              + S    SC +GY      +  C+ SG+   W    P C+ + C       NG F+ 
Sbjct: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANG-FVE 254

Query: 180 T--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237
              N  +F + +  T+ C  G      FEL+G  S+ CTS+    G W    P C     
Sbjct: 255 CFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCKAVTC 304

Query: 238 CTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
                 +NG +   +     F+      F C+ GF+++GP +V+C    +W  ++P C  
Sbjct: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364

Query: 296 ---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352
                   P+  +         +F  G    +SCE G+ L+G+  ++C P G+W    PT
Sbjct: 365 FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPT 424

Query: 353 CEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 408
           CE   C D + Q   G V     P+      +   F C+EGF+L GS+   C   G    
Sbjct: 425 CEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ--- 480

Query: 409 WNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466
           W   VP C+ + C S   P   N   +G+P+    FG    + C   P+  T   L G +
Sbjct: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC---PEGWT---LNGSA 530

Query: 467 TIRCTSDPQGNGVWSSPAPRCGILGHCQAP 496
              C +     G WS      G+L  C+AP
Sbjct: 531 ARTCGA----TGHWS------GLLPTCEAP 550



 Score =  133 bits (335), Expect = 2e-30
 Identities = 101/398 (25%), Positives = 156/398 (39%), Gaps = 31/398 (7%)

Query: 2059 FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHG-EHTLSHQ 2116
            F+        C  G++     T+QC ++G W   +P C+ V C       +G      + 
Sbjct: 200  FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259

Query: 2117 DNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLP 2176
             +F       + CE  ++L GA SL CT  G+W  E P C   +C   + Q  +G V   
Sbjct: 260  GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRA-VRQPQNGSVRCS 318

Query: 2177 LN----LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 2232
             +        +  +F C+EGF L+G +   C   G    W   +PVCE   C        
Sbjct: 319  HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPER 375

Query: 2233 GRHTGTPF--GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 2290
            G     P   G   YG    ++C+        F L G   ++C       G W +  P C
Sbjct: 376  GYMNCLPSASGSFRYGSSCEFSCE------QGFVLKGSKRLQCGP----TGEWDNEKPTC 425

Query: 2291 ELSVPAACPHPPK--IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWS 2348
            E     A   PPK  ++  H     +  +    + ++ C+ G+ L G   + CT QG W+
Sbjct: 426  EAVRCDAVHQPPKGLVRCAH---SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT 482

Query: 2349 QLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 2408
            +    C+ V CS       I+     + V  +G      C +G+TL GS    C A   W
Sbjct: 483  EEVPSCQVVKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWTLNGSAARTCGATGHW 540

Query: 2409 DPPLAKCTSRTHD--ALIVGTLSGTIFFILLIIFLSWI 2444
               L  C + T     L+ G  +  +  + L  FL W+
Sbjct: 541  SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWL 578



 Score =  132 bits (331), Expect = 6e-30
 Identities = 110/410 (26%), Positives = 169/410 (41%), Gaps = 54/410 (13%)

Query: 553 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
           +C     P +G +   H + +    S  + SC  G+      + +C+ SG    WS   P
Sbjct: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235

Query: 610 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
            C  + C      ANG F+    N  +F + +  T+ C  G      FEL+G  S+ CTS
Sbjct: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288

Query: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
           +    G W    P C           +NG +   +     F+      F C+ GF+++GP
Sbjct: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344

Query: 726 RRVKCQALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 782
            +V+C    +W  ++P C          P+  +         +F  G    +SCE G+ L
Sbjct: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404

Query: 783 RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDE 838
           +G+  ++C P G+W    PTCE   C D + Q   G V     P+      +   F C+E
Sbjct: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463

Query: 839 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKTV 896
           GF+L GS+   C   G    W   VP C+ + C S   P   N   +G+P+    FG   
Sbjct: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVC 516

Query: 897 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP 946
            + C   P+  T   L G +   C +     G WS      G+L  C+AP
Sbjct: 517 KFAC---PEGWT---LNGSAARTCGA----TGHWS------GLLPTCEAP 550



 Score =  132 bits (331), Expect = 6e-30
 Identities = 110/410 (26%), Positives = 169/410 (41%), Gaps = 54/410 (13%)

Query: 1003 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
            +C     P +G +   H + +    S  + SC  G+      + +C+ SG    WS   P
Sbjct: 179  NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235

Query: 1060 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 1117
             C  + C      ANG F+    N  +F + +  T+ C  G      FEL+G  S+ CTS
Sbjct: 236  ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288

Query: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1175
            +    G W    P C           +NG +   +     F+      F C+ GF+++GP
Sbjct: 289  S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344

Query: 1176 RRVKCQALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 1232
             +V+C    +W  ++P C          P+  +         +F  G    +SCE G+ L
Sbjct: 345  AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404

Query: 1233 RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDE 1288
            +G+  ++C P G+W    PTCE   C D + Q   G V     P+      +   F C+E
Sbjct: 405  KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463

Query: 1289 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKAV 1346
            GF+L GS+   C   G    W   VP C+ + C S   P   N   +G+P+    FG   
Sbjct: 464  GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVC 516

Query: 1347 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP 1396
             + C   P+  T   L G +   C +     G WS      G+L  C+AP
Sbjct: 517  KFAC---PEGWT---LNGSAARTCGA----TGHWS------GLLPTCEAP 550



 Score =  118 bits (296), Expect = 6e-26
 Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)

Query: 265 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 323
           +C PGF  +K  + V C AL   E      S VC  P              NFS      
Sbjct: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207

Query: 324 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 380
            SC+ GY      +M+C   G+WS   P C V  CD       NG V     P +     
Sbjct: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266

Query: 381 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 438
              F C+EGF+L G+ +  C  +G    W++  P C+ + C +     NG  R +  P  
Sbjct: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323

Query: 439 VFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 498
            F F  + N+TC+        F L G + + CT+     G W+   P C     C A  +
Sbjct: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372

Query: 499 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 556
                +    +AS  F  G+S ++ C   +  +    + C     W + K  C+   C  
Sbjct: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432

Query: 557 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
              P  G+V      I +    S   +SC  G  L G +  EC   G    W+ + P CQ
Sbjct: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489

Query: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
            + C         +   +    F  G+V  + C  G      + L G  +  C +     
Sbjct: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537

Query: 673 GIWSGPAPQCIIPNKCTPPNV 693
           G WSG  P C  P +   P V
Sbjct: 538 GHWSGLLPTCEAPTESNIPLV 558



 Score =  118 bits (296), Expect = 6e-26
 Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)

Query: 715  RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
            +C PGF  +K  + V C AL   E      S VC  P              NFS      
Sbjct: 164  KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207

Query: 774  YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 830
             SC+ GY      +M+C   G+WS   P C V  CD       NG V     P +     
Sbjct: 208  ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266

Query: 831  KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 888
               F C+EGF+L G+ +  C  +G    W++  P C+ + C +     NG  R +  P  
Sbjct: 267  TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323

Query: 889  VFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 948
             F F  + N+TC+        F L G + + CT+     G W+   P C     C A  +
Sbjct: 324  EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372

Query: 949  FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 1006
                 +    +AS  F  G+S ++ C   +  +    + C     W + K  C+   C  
Sbjct: 373  PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432

Query: 1007 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
               P  G+V      I +    S   +SC  G  L G +  EC   G    W+ + P CQ
Sbjct: 433  VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489

Query: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 1122
             + C         +   +    F  G+V  + C  G      + L G  +  C +     
Sbjct: 490  VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537

Query: 1123 GIWSGPAPQCIIPNKCTPPNV 1143
            G WSG  P C  P +   P V
Sbjct: 538  GHWSGLLPTCEAPTESNIPLV 558



 Score =  117 bits (294), Expect = 1e-25
 Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)

Query: 1165 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 1223
            +C PGF  +K  + V C AL   E      S VC  P              NFS      
Sbjct: 164  KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207

Query: 1224 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 1280
             SC+ GY      +M+C   G+WS   P C V  CD       NG V     P +     
Sbjct: 208  ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266

Query: 1281 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 1338
               F C+EGF+L G+ +  C  +G    W++  P C+ + C +     NG  R +  P  
Sbjct: 267  TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323

Query: 1339 VFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 1398
             F F  + N+TC+        F L G + + CT+     G W+   P C     C A  +
Sbjct: 324  EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372

Query: 1399 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 1456
                 +    +AS  F  G+S ++ C   +  +    + C     W + K  C+   C  
Sbjct: 373  PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432

Query: 1457 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
               P  G+V      I +    S   +SC  G  L G +  EC   G    W+ + P CQ
Sbjct: 433  VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489

Query: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
             + C         +   +    F  G+V  + C  G      + L G  +  C +     
Sbjct: 490  VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537

Query: 1573 GIWSGPAPQCIIPNKCTPPNV 1593
            G WSG  P C  P +   P V
Sbjct: 538  GHWSGLLPTCEAPTESNIPLV 558



 Score =  117 bits (293), Expect = 1e-25
 Identities = 98/386 (25%), Positives = 154/386 (39%), Gaps = 50/386 (12%)

Query: 436 PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
           PL  F +  + + +CD    RG  +      T++C S    +G WS+P P C ++  C A
Sbjct: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244

Query: 496 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 553
             +     ++   N   FP  T+  ++C    E  G   S+ C  +  W + K  CK  +
Sbjct: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303

Query: 554 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
           C+    P NG V        +    S  N++C  G  L G +  EC   G    W+ + P
Sbjct: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360

Query: 610 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
           +C+   C        G  + + +   +F YGS   + C  G      F L G   + C  
Sbjct: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412

Query: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
                G W    P C             G++   +  +  F+      F C+ GF + G 
Sbjct: 413 --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470

Query: 726 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS-PGQEVF-----YSCEP 778
            +++C +  +W  E+PSC  V C        +      K N S  G+ VF     ++C  
Sbjct: 471 TQLECTSQGQWTEEVPSCQVVKC--------SSLAVPGKINMSCSGEPVFGTVCKFACPE 522

Query: 779 GYDLRGAASMRCTPQGDWSPAAPTCE 804
           G+ L G+A+  C   G WS   PTCE
Sbjct: 523 GWTLNGSAARTCGATGHWSGLLPTCE 548



 Score =  117 bits (293), Expect = 1e-25
 Identities = 98/386 (25%), Positives = 154/386 (39%), Gaps = 50/386 (12%)

Query: 886  PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
            PL  F +  + + +CD    RG  +      T++C S    +G WS+P P C ++  C A
Sbjct: 196  PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244

Query: 946  PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 1003
              +     ++   N   FP  T+  ++C    E  G   S+ C  +  W + K  CK  +
Sbjct: 245  VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303

Query: 1004 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
            C+    P NG V        +    S  N++C  G  L G +  EC   G    W+ + P
Sbjct: 304  CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360

Query: 1060 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 1117
            +C+   C        G  + + +   +F YGS   + C  G      F L G   + C  
Sbjct: 361  VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412

Query: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1175
                 G W    P C             G++   +  +  F+      F C+ GF + G 
Sbjct: 413  --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470

Query: 1176 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS-PGQEVF-----YSCEP 1228
             +++C +  +W  E+PSC  V C        +      K N S  G+ VF     ++C  
Sbjct: 471  TQLECTSQGQWTEEVPSCQVVKC--------SSLAVPGKINMSCSGEPVFGTVCKFACPE 522

Query: 1229 GYDLRGAASMRCTPQGDWSPAAPTCE 1254
            G+ L G+A+  C   G WS   PTCE
Sbjct: 523  GWTLNGSAARTCGATGHWSGLLPTCE 548



 Score =  111 bits (278), Expect = 8e-24
 Identities = 92/378 (24%), Positives = 150/378 (39%), Gaps = 36/378 (9%)

Query: 1336 PLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 1395
            PL  F +  + + +CD    RG  +      T++C S    +G WS+P P C ++  C A
Sbjct: 196  PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244

Query: 1396 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 1453
              +     ++   N   FP  T+  ++C    E  G   S+ C  +  W + K  CK  +
Sbjct: 245  VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303

Query: 1454 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1509
            C+    P NG V        +    S  N++C  G  L G +  EC   G    W+ + P
Sbjct: 304  CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360

Query: 1510 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
            +C+   C        G  + + +   +F YGS   + C  G      F L G   + C  
Sbjct: 361  VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412

Query: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1625
                 G W    P C             G++   +  +  F+      F C+ GF + G 
Sbjct: 413  --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470

Query: 1626 RRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
             +++C +  +W  E+PSC +V +     + G+   S       G    ++C  G+ L G+
Sbjct: 471  TQLECTSQGQWTEEVPSC-QVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529

Query: 1686 ASLHCTPQGDWSPEAPRC 1703
            A+  C   G WS   P C
Sbjct: 530  AARTCGATGHWSGLLPTC 547



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 63/255 (24%), Positives = 99/255 (38%), Gaps = 29/255 (11%)

Query: 2178 NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNG--RH 2235
            N    +  S  CD G+         C+ +G    W++ +P C  + C       NG    
Sbjct: 199  NFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANGFVEC 255

Query: 2236 TGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVP 2295
               P G  P+    ++ C+        F L+G  S++CTS    +G W +  P C+    
Sbjct: 256  FQNP-GSFPWNTTCTFDCEEG------FELMGAQSLQCTS----SGNWDNEKPTCKAVTC 304

Query: 2296 AACPHPPKIQNGHYIGGH--VSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 2353
             A   P   QNG     H     +    + ++ C+ G++L G   + CT QG W+Q    
Sbjct: 305  RAVRQP---QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPV 361

Query: 2354 CKEVNCSFPL-----FMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 2408
            C+   C+        +MN +         + YG      CE G+ L+GS   QC     W
Sbjct: 362  CEAFQCTALSNPERGYMNCLP---SASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEW 418

Query: 2409 DPPLAKCTSRTHDAL 2423
            D     C +   DA+
Sbjct: 419  DNEKPTCEAVRCDAV 433



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 47/189 (24%), Positives = 69/189 (36%), Gaps = 26/189 (13%)

Query: 63  FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV---- 117
           F  G+   + C  G+  +    + C     W   K  C    C     P  G+V      
Sbjct: 388 FRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSP 447

Query: 118 IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITN 174
           I    + S   +SC +G+ L GS+   C   G    W  E P C  + C    +P  I  
Sbjct: 448 IGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKIN- 503

Query: 175 GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 234
              +S + E   +G+V  + C  G      + L G  +  C +     G WSG  P C  
Sbjct: 504 ---MSCSGEPV-FGTVCKFACPEG------WTLNGSAARTCGAT----GHWSGLLPTCEA 549

Query: 235 PNKCTPPNV 243
           P +   P V
Sbjct: 550 PTESNIPLV 558


>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
           precursor [Homo sapiens]
          Length = 373

 Score =  154 bits (390), Expect = 8e-37
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  148 bits (374), Expect = 6e-35
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  143 bits (361), Expect = 2e-33
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  132 bits (331), Expect = 6e-30
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  124 bits (310), Expect = 2e-27
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360
            L G   I C     W      C +V+ S
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289



 Score =  115 bits (288), Expect = 5e-25
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906
            +EC  G Y     +I C  N  W      C + S
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 317 PKPEEG 322



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 317  PKPEEG 322



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 40/305 (13%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYE 1875
             TI C S    N  W  P P+C     +   K+P     +S + P   ++ PV    NY 
Sbjct: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSPA----SSASGPRPTYKPPVS---NY- 313

Query: 1876 CRPGY 1880
              PGY
Sbjct: 314  --PGY 316



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113

Query: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161

Query: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219

Query: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276

Query: 1958 DKKAPICEIIS 1968
            D   P C  +S
Sbjct: 277  DPPVPKCLKVS 287


>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
           precursor [Homo sapiens]
          Length = 370

 Score =  154 bits (390), Expect = 8e-37
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  148 bits (374), Expect = 6e-35
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  143 bits (361), Expect = 2e-33
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  132 bits (331), Expect = 6e-30
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  124 bits (310), Expect = 2e-27
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360
            L G   I C     W      C +V+ S
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289



 Score =  115 bits (288), Expect = 5e-25
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906
            +EC  G Y     +I C  N  W      C + S
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 112/285 (39%), Gaps = 30/285 (10%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336
            L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849
             TI C S    N  W  P P+C     +   K+P
Sbjct: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSP 295



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113

Query: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161

Query: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219

Query: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276

Query: 1958 DKKAPICEIIS 1968
            D   P C  +S
Sbjct: 277  DPPVPKCLKVS 287


>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
           precursor [Homo sapiens]
          Length = 363

 Score =  154 bits (390), Expect = 8e-37
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  148 bits (374), Expect = 6e-35
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  143 bits (361), Expect = 2e-33
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  132 bits (331), Expect = 6e-30
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  124 bits (310), Expect = 2e-27
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360
            L G   I C     W      C +V+ S
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289



 Score =  115 bits (288), Expect = 5e-25
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906
            +EC  G Y     +I C  N  W      C + S
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 112/285 (39%), Gaps = 30/285 (10%)

Query: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
              +        C  P +    NG  V  N + +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
                 W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
           L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 30/285 (10%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336
            L GS    C      S W+  VP C ++   S    P    +G P
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYP 303



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849
             TI C S    N  W  P P+C     +   K+P
Sbjct: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSP 295



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113

Query: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161

Query: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219

Query: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276

Query: 1958 DKKAPICEIIS 1968
            D   P C  +S
Sbjct: 277  DPPVPKCLKVS 287


>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
           precursor [Homo sapiens]
          Length = 377

 Score =  154 bits (390), Expect = 8e-37
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  148 bits (374), Expect = 6e-35
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  143 bits (361), Expect = 2e-33
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  132 bits (331), Expect = 6e-30
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  124 bits (310), Expect = 2e-27
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360
            L G   I C     W      C +V+ S
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289



 Score =  115 bits (288), Expect = 5e-25
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906
            +EC  G Y     +I C  N  W      C + S
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 317 PKPEEG 322



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 317  PKPEEG 322



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 40/305 (13%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYE 1875
             TI C S    N  W  P P+C     +   K+P     +S + P   ++ PV    NY 
Sbjct: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSPA----SSASGPRPTYKPPVS---NY- 313

Query: 1876 CRPGY 1880
              PGY
Sbjct: 314  --PGY 316



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113

Query: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161

Query: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219

Query: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276

Query: 1958 DKKAPICEIIS 1968
            D   P C  +S
Sbjct: 277  DPPVPKCLKVS 287


>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
           precursor [Homo sapiens]
          Length = 384

 Score =  154 bits (390), Expect = 8e-37
 Identities = 94/277 (33%), Positives = 131/277 (47%), Gaps = 13/277 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 296
             V F C  GF + G   + C + + W+P +P C +V
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  148 bits (374), Expect = 6e-35
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 11/239 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV 2099
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 746
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  147 bits (370), Expect = 2e-34
 Identities = 85/239 (35%), Positives = 119/239 (49%), Gaps = 11/239 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  143 bits (361), Expect = 2e-33
 Identities = 84/239 (35%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1646
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +V
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286



 Score =  132 bits (331), Expect = 6e-30
 Identities = 88/283 (31%), Positives = 128/283 (45%), Gaps = 18/283 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1463
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 563
            +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  130 bits (327), Expect = 2e-29
 Identities = 87/283 (30%), Positives = 127/283 (44%), Gaps = 18/283 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKS----CKTPPDPVNG 1013
             +Y     +I C  N  W  P   C + S     K+P    +G
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASG 301



 Score =  124 bits (310), Expect = 2e-27
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 14/268 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIWSQLDHYCKEVNCS 2360
            L G   I C     W      C +V+ S
Sbjct: 262  LDGSDTIVCDSNSTWDPPVPKCLKVSTS 289



 Score =  115 bits (288), Expect = 5e-25
 Identities = 80/274 (29%), Positives = 122/274 (44%), Gaps = 21/274 (7%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKS 1906
            +EC  G Y     +I C  N  W      C + S
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 317 PKPEEG 322



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 32/306 (10%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C ++   S    P    +G      P     NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKP--PVSNYPGY 316

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 317  PKPEEG 322



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 40/305 (13%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYE 1875
             TI C S    N  W  P P+C     +   K+P     +S + P   ++ PV    NY 
Sbjct: 266  DTIVCDS----NSTWDPPVPKCLKVSTSSTTKSPA----SSASGPRPTYKPPVS---NY- 313

Query: 1876 CRPGY 1880
              PGY
Sbjct: 314  --PGY 316



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 62/251 (24%), Positives = 100/251 (39%), Gaps = 27/251 (10%)

Query: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
            ++G +V + C +G+       +H +     +    S   C    CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA- 113

Query: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN-GVWSSPAPRCELSVRAGH 1845
            +G   +G ++ + C+        + LIGE  + C  +  G+  +WS   P CE  +    
Sbjct: 114  NGTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICEKVL---- 161

Query: 1846 CKTPEQFPFASPTIP-INDFEFPVGTSLNYECRPGYFGKMFS------ISCLENLVWSSV 1898
            C  P +      T   +  FE+    ++ Y C P      FS      I C +N VWS  
Sbjct: 162  CTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219

Query: 1899 EDNCRRKSCG-PPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW 1957
               C+   C  P  E    +        + +TV + C++GF L GS +  C    +N TW
Sbjct: 220  APECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTW 276

Query: 1958 DKKAPICEIIS 1968
            D   P C  +S
Sbjct: 277  DPPVPKCLKVS 287


>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
           precursor [Homo sapiens]
          Length = 369

 Score =  154 bits (388), Expect = 1e-36
 Identities = 94/280 (33%), Positives = 132/280 (47%), Gaps = 13/280 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP 299
             V F C  GF + G   + C + + W+P +P C +  +P
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289



 Score =  147 bits (372), Expect = 1e-34
 Identities = 84/242 (34%), Positives = 114/242 (47%), Gaps = 11/242 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 2101 QP 2102
            +P
Sbjct: 288  RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 748 QP 749
           +P
Sbjct: 288 RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1198 QP 1199
            +P
Sbjct: 288  RP 289



 Score =  142 bits (359), Expect = 3e-33
 Identities = 84/242 (34%), Positives = 119/242 (49%), Gaps = 11/242 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1648 QP 1649
            +P
Sbjct: 288  RP 289



 Score =  132 bits (332), Expect = 4e-30
 Identities = 87/278 (31%), Positives = 126/278 (45%), Gaps = 14/278 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
            +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  122 bits (305), Expect = 6e-27
 Identities = 75/255 (29%), Positives = 115/255 (45%), Gaps = 14/255 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIW 2347
            L G   I C     W
Sbjct: 262  LDGSDTIVCDSNSTW 276



 Score =  116 bits (290), Expect = 3e-25
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 24/279 (8%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKSCGPPP 1911
            +EC  G Y     +I C  N  W      C +   GP P
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK---GPRP 289



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 302 PKPEEG 307



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 302  PKPEEG 307



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283


>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
           precursor [Homo sapiens]
          Length = 362

 Score =  154 bits (388), Expect = 1e-36
 Identities = 94/280 (33%), Positives = 132/280 (47%), Gaps = 13/280 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP 299
             V F C  GF + G   + C + + W+P +P C +  +P
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289



 Score =  147 bits (372), Expect = 1e-34
 Identities = 84/242 (34%), Positives = 114/242 (47%), Gaps = 11/242 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 2101 QP 2102
            +P
Sbjct: 288  RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 748 QP 749
           +P
Sbjct: 288 RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1198 QP 1199
            +P
Sbjct: 288  RP 289



 Score =  142 bits (359), Expect = 3e-33
 Identities = 84/242 (34%), Positives = 119/242 (49%), Gaps = 11/242 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1648 QP 1649
            +P
Sbjct: 288  RP 289



 Score =  132 bits (332), Expect = 4e-30
 Identities = 87/278 (31%), Positives = 126/278 (45%), Gaps = 14/278 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
            +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  122 bits (305), Expect = 6e-27
 Identities = 75/255 (29%), Positives = 115/255 (45%), Gaps = 14/255 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIW 2347
            L G   I C     W
Sbjct: 262  LDGSDTIVCDSNSTW 276



 Score =  116 bits (290), Expect = 3e-25
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 24/279 (8%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKSCGPPP 1911
            +EC  G Y     +I C  N  W      C +   GP P
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK---GPRP 289



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 302 PKPEEG 307



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 302  PKPEEG 307



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283


>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
           precursor [Homo sapiens]
          Length = 349

 Score =  154 bits (388), Expect = 1e-36
 Identities = 94/280 (33%), Positives = 132/280 (47%), Gaps = 13/280 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP 299
             V F C  GF + G   + C + + W+P +P C +  +P
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289



 Score =  147 bits (372), Expect = 1e-34
 Identities = 84/242 (34%), Positives = 114/242 (47%), Gaps = 11/242 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 2101 QP 2102
            +P
Sbjct: 288  RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 748 QP 749
           +P
Sbjct: 288 RP 289



 Score =  146 bits (368), Expect = 3e-34
 Identities = 85/242 (35%), Positives = 120/242 (49%), Gaps = 11/242 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1198 QP 1199
            +P
Sbjct: 288  RP 289



 Score =  142 bits (359), Expect = 3e-33
 Identities = 84/242 (34%), Positives = 119/242 (49%), Gaps = 11/242 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287

Query: 1648 QP 1649
            +P
Sbjct: 288  RP 289



 Score =  132 bits (332), Expect = 4e-30
 Identities = 87/278 (31%), Positives = 126/278 (45%), Gaps = 14/278 (5%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
            +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  130 bits (328), Expect = 1e-29
 Identities = 86/278 (30%), Positives = 125/278 (44%), Gaps = 14/278 (5%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012
             +Y     +I C  N  W  P   C +    T   PV+
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296



 Score =  122 bits (305), Expect = 6e-27
 Identities = 75/255 (29%), Positives = 115/255 (45%), Gaps = 14/255 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIW 2347
            L G   I C     W
Sbjct: 262  LDGSDTIVCDSNSTW 276



 Score =  116 bits (290), Expect = 3e-25
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 24/279 (8%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKSCGPPP 1911
            +EC  G Y     +I C  N  W      C +   GP P
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK---GPRP 289



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCD 901
           L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 902 PHPDRG 907
           P P+ G
Sbjct: 302 PKPEEG 307



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/306 (25%), Positives = 117/306 (38%), Gaps = 47/306 (15%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCD 1351
            L GS    C      S W+  VP C          +   R T KP          NY   
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC----------LKGPRPTYKP-------PVSNYPGY 301

Query: 1352 PHPDRG 1357
            P P+ G
Sbjct: 302  PKPEEG 307



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283


>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
           precursor [Homo sapiens]
          Length = 348

 Score =  153 bits (387), Expect = 2e-36
 Identities = 94/283 (33%), Positives = 132/283 (46%), Gaps = 13/283 (4%)

Query: 25  GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
           G LLA +VLL    +   C  P              + + IG  ++Y+C+ GY   P   
Sbjct: 18  GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75

Query: 82  FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
              IC +N  W    D  C R++C    DP+NG      G  +FG Q+ + C +GY LIG
Sbjct: 76  THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135

Query: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
                C + G   IW  + PIC+++ C  PP I NG    +  E F Y   VTY C+P +
Sbjct: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194

Query: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
            G   F L+GE +IYC  N     +WS  AP+C +  KC  P VENG  +S     F   
Sbjct: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249

Query: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD 302
             V F C  GF + G   + C + + W+P +P C +    P +
Sbjct: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYPKPEE 292



 Score =  148 bits (374), Expect = 6e-35
 Identities = 85/245 (34%), Positives = 114/245 (46%), Gaps = 11/245 (4%)

Query: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
            + +G  ++Y+C+ GYF          C  N  W  V D+ C R++C    +P NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
            N   +FG  +++ CNEG+ LIG     C + G+   W  K PICE + C PPP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
              +    F     VTY C   P G   F L+GE +IYC        VWS   P C    K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227

Query: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
            C  P VEN  ++ G    F     + F C  GF + GS T+ C +N  W P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287

Query: 2101 QPPPE 2105
              P E
Sbjct: 288  PKPEE 292



 Score =  145 bits (367), Expect = 4e-34
 Identities = 85/245 (34%), Positives = 120/245 (48%), Gaps = 11/245 (4%)

Query: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
           + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
               + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
             +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
           C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287

Query: 748 QPPPD 752
             P +
Sbjct: 288 PKPEE 292



 Score =  145 bits (367), Expect = 4e-34
 Identities = 85/245 (34%), Positives = 120/245 (48%), Gaps = 11/245 (4%)

Query: 963  FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
              +  E F Y   VTY C+P + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287

Query: 1198 QPPPD 1202
              P +
Sbjct: 288  PKPEE 292



 Score =  143 bits (361), Expect = 2e-33
 Identities = 85/245 (34%), Positives = 119/245 (48%), Gaps = 11/245 (4%)

Query: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
            + IG  + Y+C+  Y+  P   T   C  N  W    D  C R++C    DP+NG  V  
Sbjct: 54   YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
                + G ++++ C  G+ LIG     C L G+ A WS KPPIC+++ C  PP I NG  
Sbjct: 114  NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173

Query: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
              +  E F Y   VTY C+  + G   F L+GE +IYC  N     +WS  AP+C +  K
Sbjct: 174  TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227

Query: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
            C  P VENG  +S     F     V F C  GF + G   + C + + W+P +P C +  
Sbjct: 228  CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287

Query: 1648 QPPPE 1652
              P E
Sbjct: 288  PKPEE 292



 Score =  131 bits (330), Expect = 7e-30
 Identities = 88/281 (31%), Positives = 127/281 (45%), Gaps = 18/281 (6%)

Query: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
             ++W+   P+CE++ C  PP I NG+HT   +EVF +  AV Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 1426 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV 1465
             +Y     +I C  N  W  P   C     K  P P  G++
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC----LKGYPKPEEGIL 295



 Score =  130 bits (326), Expect = 2e-29
 Identities = 87/281 (30%), Positives = 126/281 (44%), Gaps = 18/281 (6%)

Query: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
           L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28  LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
           P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88  PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
            ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
           STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 526 EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV 565
            +Y     +I C  N  W  P   C     K  P P  G++
Sbjct: 259 GFYLDGSDTIVCDSNSTWDPPVPKC----LKGYPKPEEGIL 295



 Score =  130 bits (326), Expect = 2e-29
 Identities = 87/281 (30%), Positives = 126/281 (44%), Gaps = 18/281 (6%)

Query: 740  LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
            L S S  C+ PP     E   + K  +  G+ V Y C+ GY      A    C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 798  PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
            P +     +    ++   LNG+ + P N   + G ++ F+C+EG+ L G    YC L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 856  ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
             ++W+   P+CE++ C  PP I NG+HT   +EVF +   V Y+CDP P     F LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205

Query: 916  STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
            STI C      N VWS  AP C ++  C+ P   +    +       F    ++ +EC  
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258

Query: 976  EYY-GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV 1015
             +Y     +I C  N  W  P   C     K  P P  G++
Sbjct: 259  GFYLDGSDTIVCDSNSTWDPPVPKC----LKGYPKPEEGIL 295



 Score =  122 bits (305), Expect = 6e-27
 Identities = 75/255 (29%), Positives = 115/255 (45%), Gaps = 14/255 (5%)

Query: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
            S  C+ PP     E     +  +  G+ V Y C+  Y      + H  C     W P + 
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91

Query: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
                +    ++    +G+ + P N   + G ++ F+C+EG+ L G    +C L G  A+W
Sbjct: 92   DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150

Query: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
            +   P+CE++ C  PP I NG+HT +      Y   ++Y+CD  P     F+LIGES+I 
Sbjct: 151  SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209

Query: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
            C      N VWS  AP C++     C   P ++NG  I G    +    T+ + CD G+ 
Sbjct: 210  CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 2333 LVGKGFIFCTDQGIW 2347
            L G   I C     W
Sbjct: 262  LDGSDTIVCDSNSTW 276



 Score =  115 bits (287), Expect = 7e-25
 Identities = 82/280 (29%), Positives = 124/280 (44%), Gaps = 23/280 (8%)

Query: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
            L S S  C+ PP     E     +  +  G+ V Y C+ GY      + H  C     W 
Sbjct: 28   LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87

Query: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
            P +     +    ++    +G+ + P N   + G ++ F+C+EG+ L G  + +C L G 
Sbjct: 88   PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             ++W+   P+CE + C  PP I NG+HT +      Y   ++Y+CDP P     F+LIGE
Sbjct: 147  VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205

Query: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
            STI C      N VWS  AP C++      C+    FP       I+ F  +F    ++ 
Sbjct: 206  STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253

Query: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNCRRKSCGPPPE 1912
            +EC  G Y     +I C  N  W      C +    P PE
Sbjct: 254  FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY--PKPE 291



 Score =  110 bits (274), Expect = 2e-23
 Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)

Query: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
            ++G +V + C +G+      A+H +          S   C +  CP     LNG+     
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
             G   +G ++ + C+        + LIGE  + C  + +G+  +WS   P CE      C
Sbjct: 115  -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162

Query: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
              PPKI+NG +    V ++     ++Y CDP      + L+G+  I+C D  +WS+    
Sbjct: 163  TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222

Query: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
            CK V C FP+  NG  K++    K ++Y   V  +C+ G+ L+GS    C ++  WDPP+
Sbjct: 223  CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280

Query: 2413 AKC 2415
             KC
Sbjct: 281  PKC 283



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)

Query: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
            ++G R++Y C  G+  I   +   I   N          C R  C       NG  +  N
Sbjct: 55   EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114

Query: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
               + +G  + + CN G      + L+GE  +YC      V IWSG  P C       PP
Sbjct: 115  G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166

Query: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
             ++NG        +F   + V + C P      F + G   + C   + W    P C  V
Sbjct: 167  KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
                P + +G+        F     V + C+ G+ L G+ ++ C     W P  P+C
Sbjct: 227  KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)

Query: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
            +C  PP  F  M  I     +   G  V+Y C +G+  I  P  T  +   N TW     
Sbjct: 34   ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91

Query: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
              C   +C       NG     N T +  G  + + C+ G      + L+GE  +YC  K
Sbjct: 92   DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144

Query: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
               V +WS  PP C        P+++N          F   + + + C P      F ++
Sbjct: 145  GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
            G  T+ C  N  W    P C  V    P + +G+        F     V + C+  + L 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263

Query: 2137 GAASLHCTPQGDWSPEAPRC 2156
            G+ ++ C     W P  P+C
Sbjct: 264  GSDTIVCDSNSTWDPPVPKC 283



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 72/265 (27%), Positives = 108/265 (40%), Gaps = 30/265 (11%)

Query: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
              ++  W  + P C +V C PPP+I +G+HT S  + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
            G ++++C     WS  AP C V  C      + +G+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1742 LKGSSVSHCVLVGMRSLWNNSVPVC 1766
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 70/265 (26%), Positives = 106/265 (40%), Gaps = 30/265 (11%)

Query: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
           C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35  CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
              +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87  LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
             ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
           G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 842 LKGSSASYCVLAGMESLWNSSVPVC 866
           L GS    C      S W+  VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 70/265 (26%), Positives = 106/265 (40%), Gaps = 30/265 (11%)

Query: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
            C  PPT    + I   +  +  G  V Y+C  G      F +   P +   +  D+   W
Sbjct: 35   CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86

Query: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
               +        C  P +    NG  V  N   +     + F C  G+ + G   + C+ 
Sbjct: 87   LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143

Query: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
              ++  W  + P C +V C PPP + + + T  + + F     V YSC+P      + L 
Sbjct: 144  KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203

Query: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
            G +++ C     WS AAP C+V  C      + NG+ +  F       A V F CD+GF 
Sbjct: 204  GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261

Query: 1292 LKGSSASYCVLAGMESLWNSSVPVC 1316
            L GS    C      S W+  VP C
Sbjct: 262  LDGSDTIVC---DSNSTWDPPVPKC 283



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)

Query: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
            PP  E   L+   +  + + E V+++C+ G+    P      C   + W P    +C R 
Sbjct: 38   PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97

Query: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
             C    + L+G+  P++   +  G ++ + C  GY L G   L+C  +G    WS + P 
Sbjct: 98   TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
            C    C     ++ +G+  F      +    V++ CD     + F L G S  +C   G 
Sbjct: 157  CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212

Query: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
             S+W+ + P C+ + C   P + NG+          Y   + + CD        F L G 
Sbjct: 213  NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265

Query: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
             TI C S    N  W  P P+C
Sbjct: 266  DTIVCDS----NSTWDPPVPKC 283



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 65/274 (23%), Positives = 112/274 (40%), Gaps = 33/274 (12%)

Query: 2038 TNKCTAPEVENAIRVPGN-RSFFTLTEIIRFRCQPGFVMV---GSHTVQCQTNGRWGPKL 2093
            ++ C  P    A+ + G  + ++ + E + ++C+ G+  +    +HT+ C  N  W P  
Sbjct: 32   SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVS 90

Query: 2094 PH-CSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD--- 2148
               C R  C    + L+G+  +     +  G ++ + C   Y L G   L+C  +G    
Sbjct: 91   DDACYRETCPYIRDPLNGQ-AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149

Query: 2149 WSPEAPRCTVKSCDD--FLGQLPHGRVLLPLNLQLGAKVSFVCD-----EGFRLKGRSAS 2201
            WS + P C    C     +    H    + +   L A V++ CD     + F L G S  
Sbjct: 150  WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTI 208

Query: 2202 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 2261
            +C   G  ++W+ + P C+ + C   P + NG+          +GK+  Y      +   
Sbjct: 209  YC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMFECDK 258

Query: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVP 2295
             F L G  +I C S    N  W  P P+C    P
Sbjct: 259  GFYLDGSDTIVCDS----NSTWDPPVPKCLKGYP 288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.462 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130,442,810
Number of Sequences: 37866
Number of extensions: 7438928
Number of successful extensions: 28824
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 14637
Number of HSP's gapped (non-prelim): 3510
length of query: 2489
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2370
effective length of database: 13,741,464
effective search space: 32567269680
effective search space used: 32567269680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.