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Search of human proteins with 7706643
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706643 pleckstrin 2 [Homo sapiens]
(353 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706643 pleckstrin 2 [Homo sapiens] 713 0.0
gi|156616273 pleckstrin [Homo sapiens] 251 9e-67
gi|93102364 SWAP-70 protein [Homo sapiens] 55 7e-08
gi|50234893 pleckstrin homology domain containing, family A (pho... 55 1e-07
gi|31377720 pleckstrin homology domain containing, family A (pho... 55 1e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 54 3e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 53 4e-07
gi|154146216 pleckstrin homology domain containing, family A (ph... 49 7e-06
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 48 1e-05
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 48 1e-05
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 47 2e-05
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 47 2e-05
gi|55741447 pleckstrin homology domain containing, family H (wit... 47 3e-05
gi|217416392 pleckstrin homology domain containing, family H (wi... 47 3e-05
gi|7019505 cytohesin 4 [Homo sapiens] 46 4e-05
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 46 4e-05
gi|189571664 DEP domain containing 6 [Homo sapiens] 45 1e-04
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 45 1e-04
gi|154354979 myosin X [Homo sapiens] 44 2e-04
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 44 2e-04
gi|4758968 cytohesin 3 [Homo sapiens] 44 3e-04
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 42 6e-04
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 42 6e-04
gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens] 42 8e-04
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 42 8e-04
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 42 8e-04
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 42 8e-04
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 42 8e-04
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 42 0.001
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 42 0.001
>gi|7706643 pleckstrin 2 [Homo sapiens]
Length = 353
Score = 713 bits (1841), Expect = 0.0
Identities = 353/353 (100%), Positives = 353/353 (100%)
Query: 1 MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC 60
MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC
Sbjct: 1 MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC 60
Query: 61 PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS 120
PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS
Sbjct: 61 PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS 120
Query: 121 FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA 180
FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA
Sbjct: 121 FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA 180
Query: 181 VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS 240
VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS
Sbjct: 181 VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS 240
Query: 241 TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL 300
TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL
Sbjct: 241 TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL 300
Query: 301 VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT 353
VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT
Sbjct: 301 VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT 353
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 251 bits (640), Expect = 9e-67
Identities = 133/352 (37%), Positives = 207/352 (58%), Gaps = 11/352 (3%)
Query: 1 MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC 60
ME ++EG+LVK+G + + WK W +L ++ + +YK + PKG I L G T+T
Sbjct: 1 MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNS---PKGMIPLKGSTLTS 57
Query: 61 PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS 120
PC ++ R + K+ T ++F +A EERDAW +I AI + G+ S R S
Sbjct: 58 PCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRS 117
Query: 121 FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA 180
+LP I L + M D+ GI+ + + F G+ ++DWL+SN +R E
Sbjct: 118 IRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEG 177
Query: 181 VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAES--YKKKISPKEEIS 238
+ +AS L+ E +L+P G S A+ G FLD+ A Y F +S + ++ S +++
Sbjct: 178 LMIASSLLNEGYLQPAGDMSKSAV-DGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVI 236
Query: 239 LSTVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRG 298
L E G ++KQG L KQGH+RKNWKVR+F+LR+DPA+LHYYDP+ E+ P+G LRG
Sbjct: 237 LKE-EFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAED-PLGAIHLRG 294
Query: 299 SLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
+V+++E N + + + + NLF++IT D+ HY++QA++ ER EWI AI+
Sbjct: 295 CVVTSVESN---SNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
Score = 55.5 bits (132), Expect = 7e-08
Identities = 38/109 (34%), Positives = 52/109 (47%), Gaps = 9/109 (8%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNT--LVYYKLEGGRRVTPPKGRILLDGCTITCPC 62
++K+G L+K+GH NWK R FILR++ L YY G P G I L GC +T
Sbjct: 245 IIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAE---DPLGAIHLRGCVVTSVE 301
Query: 63 LEYENRPL----LIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQ 107
R L ++ T YFL+A + +ER W I A G+
Sbjct: 302 SNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK 350
Score = 47.0 bits (110), Expect = 3e-05
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 12/104 (11%)
Query: 249 VKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGS-LVSALEDN 307
+++GYL K+G WK VL +D + +Y K +N P G L+GS L S +D
Sbjct: 6 IREGYLVKKGSVFNTWKPMWVVLLEDG--IEFYK-KKSDNSPKGMIPLKGSTLTSPCQDF 62
Query: 308 GVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKK 351
G V FK+ T ++ QA+ ER W+ IKK
Sbjct: 63 GKRMFV--------FKITTTKQQDHFFQAAFLEERDAWVRDIKK 98
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 55.5 bits (132), Expect = 7e-08
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 8/102 (7%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDG--CTITCPC 62
VLK+G+++K+GH NW RWF+L+ N + YY E + KG ILLD C + P
Sbjct: 211 VLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSED---LKDKKGDILLDENCCVESLPD 267
Query: 63 LEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIH 104
+ + L+K +T + + A ++++ W I IH
Sbjct: 268 KDGKKCLFLVKCFDKT---FEISASDKKKKQEWIQAIHSTIH 306
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/107 (31%), Positives = 55/107 (51%), Gaps = 11/107 (10%)
Query: 243 ELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVS 302
EL V+KQGY+ K+GH+RKNW R FVL+ P + YY +++ +G ++
Sbjct: 206 ELILDVLKQGYMMKKGHRRKNWTERWFVLK--PNIISYYVSEDLKDK-------KGDIL- 255
Query: 303 ALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349
L++N + ++ D + I AS K ++ EWI+AI
Sbjct: 256 -LDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAI 301
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/113 (33%), Positives = 63/113 (55%), Gaps = 9/113 (7%)
Query: 2 EDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGR---RVTPPKGRILLDGCTI 58
+ V+K G+ VK+G ++ NWK R+F L +NT+ Y+K E + RV P K + C
Sbjct: 189 DSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQ 248
Query: 59 TCPCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQ-PGK 110
+ + R L ++ T TS ++++A S EE +W ++GAI A + PG+
Sbjct: 249 S----DIMMRDNLFEIVT-TSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGR 296
Score = 46.2 bits (108), Expect = 4e-05
Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 13/104 (12%)
Query: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
V+K GY KQG KNWK R F L D + Y+ S+ E P+ L+ E +
Sbjct: 192 VIKAGYCVKQGAVMKNWKRRYFQL--DENTIGYF-KSELEKEPLRVIPLK-------EVH 241
Query: 308 GVPTGVKGNV--QGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349
V + ++ + NLF+++T T +Y+QA S E WI+A+
Sbjct: 242 KVQECKQSDIMMRDNLFEIVTTSRT-FYVQADSPEEMHSWIKAV 284
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/113 (33%), Positives = 63/113 (55%), Gaps = 9/113 (7%)
Query: 2 EDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGR---RVTPPKGRILLDGCTI 58
+ V+K G+ VK+G ++ NWK R+F L +NT+ Y+K E + RV P K + C
Sbjct: 189 DSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQ 248
Query: 59 TCPCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQ-PGK 110
+ + R L ++ T TS ++++A S EE +W ++GAI A + PG+
Sbjct: 249 S----DIMMRDNLFEIVT-TSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGR 296
Score = 46.2 bits (108), Expect = 4e-05
Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 13/104 (12%)
Query: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
V+K GY KQG KNWK R F L D + Y+ S+ E P+ L+ E +
Sbjct: 192 VIKAGYCVKQGAVMKNWKRRYFQL--DENTIGYF-KSELEKEPLRVIPLK-------EVH 241
Query: 308 GVPTGVKGNV--QGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349
V + ++ + NLF+++T T +Y+QA S E WI+A+
Sbjct: 242 KVQECKQSDIMMRDNLFEIVTTSRT-FYVQADSPEEMHSWIKAV 284
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 53.5 bits (127), Expect = 3e-07
Identities = 36/108 (33%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDG--CTITCPC 62
VLK+G+L KRGH+ NW RWF L+ + L Y+ G +G I LD C P
Sbjct: 217 VLKQGYLWKRGHLRRNWAERWFQLQPSCLCYF---GSEECKEKRGIIPLDAHCCVEVLP- 272
Query: 63 LEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGK 110
+ + + + +KT T Y + A +R W I AI GK
Sbjct: 273 -DRDGKRCMFCVKTANRT-YEMSASDTRQRQEWTAAIQMAIRLQAEGK 318
Score = 41.6 bits (96), Expect = 0.001
Identities = 37/109 (33%), Positives = 53/109 (48%), Gaps = 13/109 (11%)
Query: 243 ELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSK-EENRPVGGFSLRGSLV 301
EL V+KQGYL K+GH R+NW R F L+ P+ L Y+ + +E R + V
Sbjct: 212 ELIQDVLKQGYLWKRGHLRRNWAERWFQLQ--PSCLCYFGSEECKEKRGIIPLDAH-CCV 268
Query: 302 SALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
L D + + +F V T + T Y + AS +R EW AI+
Sbjct: 269 EVLPDR--------DGKRCMFCVKTANRT-YEMSASDTRQRQEWTAAIQ 308
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 53.1 bits (126), Expect = 4e-07
Identities = 37/112 (33%), Positives = 56/112 (50%), Gaps = 9/112 (8%)
Query: 246 GTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALE 305
G V+K G+L KQ KNW+ R FVLR D F Y K+E +P G SL+G+ V+ L
Sbjct: 36 GPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLF---YYKDKDEIKPQGFISLQGTQVTELP 92
Query: 306 DNGVPTG-----VKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKL 352
G + G KV + + ASS+ + +W++AI+++
Sbjct: 93 PGPEDPGKHLFEISPGGAGEREKVPANPEA-LLLMASSQRDMEDWVQAIRRV 143
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/55 (43%), Positives = 33/55 (60%), Gaps = 3/55 (5%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTIT 59
VLK G+L K+ I+ NW+ RWF+LR + L YYK + P+G I L G +T
Sbjct: 38 VLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYK---DKDEIKPQGFISLQGTQVT 89
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 48.9 bits (115), Expect = 7e-06
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 8/105 (7%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCL- 63
++K G+ VK+G++ +WK R+F L T+ Y+K E R P I L T CL
Sbjct: 199 LIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE---PLRTIFLKDVLKTHECLV 255
Query: 64 ---EYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHA 105
+ R L ++ T + T ++++A S E+ +W EI A+ A
Sbjct: 256 KSGDLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEIGAAVQA 299
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 7/102 (6%)
Query: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
++K GY KQG+ RK+WK R F L F Y +++ P+ L+ L + +
Sbjct: 199 LIKSGYCVKQGNVRKSWKRRFFAL---DDFTICYFKCEQDREPLRTIFLKDVLKT--HEC 253
Query: 308 GVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAI 349
V +G ++ NLF++IT T +Y+QA S + WI+ I
Sbjct: 254 LVKSG-DLLMRDNLFEIITSSRT-FYVQADSPEDMHSWIKEI 293
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 11/98 (11%)
Query: 6 LKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTI----TCP 61
+K G+L K+ IV NW+ R+F+LR L YYK E T P+G + L GCTI T P
Sbjct: 48 IKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDE---EDTKPQGCMYLPGCTIKEIATNP 104
Query: 62 ----CLEYENRPLLIKLKTQTSTEYFLEACSREERDAW 95
+E P Y L A S+ E + W
Sbjct: 105 EEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEW 142
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 16/111 (14%)
Query: 249 VKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNG 308
+K G+L KQ KNW+ R FVLR YY +E+ +P G L G + + N
Sbjct: 48 IKMGWLKKQRSIVKNWQQRYFVLRAQQL---YYYKDEEDTKPQGCMYLPGCTIKEIATNP 104
Query: 309 VPTGVKGNVQGNLFKVITKD-------DTHYYIQASSKAERAEWIEAIKKL 352
G +F++I Y + ASS+AE EW++ ++++
Sbjct: 105 EEAG------KFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRV 149
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 11/98 (11%)
Query: 6 LKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTI----TCP 61
+K G+L K+ IV NW+ R+F+LR L YYK E T P+G + L GCTI T P
Sbjct: 41 IKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDE---EDTKPQGCMYLPGCTIKEIATNP 97
Query: 62 ----CLEYENRPLLIKLKTQTSTEYFLEACSREERDAW 95
+E P Y L A S+ E + W
Sbjct: 98 EEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEW 135
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 16/111 (14%)
Query: 249 VKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNG 308
+K G+L KQ KNW+ R FVLR YY +E+ +P G L G + + N
Sbjct: 41 IKMGWLKKQRSIVKNWQQRYFVLRAQQL---YYYKDEEDTKPQGCMYLPGCTIKEIATNP 97
Query: 309 VPTGVKGNVQGNLFKVITKD-------DTHYYIQASSKAERAEWIEAIKKL 352
G +F++I Y + ASS+AE EW++ ++++
Sbjct: 98 EEAG------KFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRV 142
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 249 VKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNG 308
+K G+L KQG K W R FVL+ D YY ++E +P+G L G+ VS N
Sbjct: 21 IKCGWLRKQGGFVKTWHTRWFVLKGDQL---YYFKDEDETKPLGTIFLPGNKVSEHPCNE 77
Query: 309 VPTG--VKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKL 352
G + V G +T + Y + AS++ + +W+++I+++
Sbjct: 78 ENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRV 123
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/107 (29%), Positives = 47/107 (43%), Gaps = 12/107 (11%)
Query: 6 LKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTIT-CPCLE 64
+K G+L K+G V W RWF+L+ + L Y+K E T P G I L G ++ PC E
Sbjct: 21 IKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDED---ETKPLGTIFLPGNKVSEHPCNE 77
Query: 65 YENRPLLIKL--------KTQTSTEYFLEACSREERDAWAFEITGAI 103
L ++ T Y L A ++ + + W I I
Sbjct: 78 ENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 15/90 (16%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRIL-LDGCT-------- 57
KEG+L K+G +V WK RWF L +N L Y+K +++P RIL L C+
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFK----DQMSPEPIRILDLTECSAVQFDYSQ 222
Query: 58 --ITCPCLEYENRPLLIKLKTQTSTEYFLE 85
+ C CL + R + KT + +++
Sbjct: 223 ERVNCFCLVFPFRTFYLCAKTGVEADEWIK 252
Score = 32.0 bits (71), Expect = 0.86
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 12/101 (11%)
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGV 309
K+GYL KQG K WK R F L ++ L Y+ K++ P L + SA++ +
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNE--LKYF---KDQMSPEPIRILDLTECSAVQFDYS 221
Query: 310 PTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
V N F ++ T +Y+ A + E EWI+ ++
Sbjct: 222 QERV------NCFCLVFPFRT-FYLCAKTGVEADEWIKILR 255
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 47.0 bits (110), Expect = 3e-05
Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 17/155 (10%)
Query: 200 SMGAIRS-GDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSG-TVVKQGYLAKQ 257
SM ++ S GD A D+ +L + + K+ S + L G ++ K GYL K
Sbjct: 531 SMSSLSSEGDYA--IPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKM 588
Query: 258 GHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNV 317
G + K WK R FVLR+ ++Y PS +P G L S + G T
Sbjct: 589 GSQVKTWKRRWFVLRQG-QIMYYKSPSDVIRKPQGQVDL-NSRCQIVRGEGSQT------ 640
Query: 318 QGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKL 352
F++I++ T YY+ A S + EWI ++ L
Sbjct: 641 ----FQLISEKKT-YYLTADSPSLLEEWIRVLQSL 670
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/48 (41%), Positives = 30/48 (62%), Gaps = 1/48 (2%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLD 54
K G+L+K G V WK RWF+LRQ ++YYK + P+G++ L+
Sbjct: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYK-SPSDVIRKPQGQVDLN 627
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLEYE 66
K G+L+K V +WK RWF+L+ L+YYK + P+G I L + +C L +
Sbjct: 706 KSGYLLKMSGKVKSWKRRWFVLKGGELLYYK-SPSDVIRKPQGHIEL---SASCSILRGD 761
Query: 67 NRPLLIKLKTQTSTEYFLEACSREERDAW 95
N+ ++L T+ T Y+L A S + W
Sbjct: 762 NKQ-TVQLTTEKHT-YYLTADSPNILEEW 788
Score = 45.4 bits (106), Expect = 8e-05
Identities = 35/103 (33%), Positives = 45/103 (43%), Gaps = 13/103 (12%)
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGV 309
K GYL K K K+WK R FVL K L+Y PS +P G L S DN
Sbjct: 706 KSGYLLKMSGKVKSWKRRWFVL-KGGELLYYKSPSDVIRKPQGHIELSASCSILRGDN-- 762
Query: 310 PTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKL 352
K VQ +T + YY+ A S EWI+ ++ +
Sbjct: 763 ----KQTVQ------LTTEKHTYYLTADSPNILEEWIKVLQNV 795
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 46.2 bits (108), Expect = 4e-05
Identities = 39/116 (33%), Positives = 51/116 (43%), Gaps = 22/116 (18%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCP----- 61
+EG+L+K G V WK RWFIL N L Y++ + P+G I L+ ++
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKE---PRGIIPLENLSVQKVDDPKK 318
Query: 62 --CLEYEN---RPLLIK-LKTQ--------TSTEYFLEACSREERDAWAFEITGAI 103
CLE N R IK KT Y + A S EERD W I +I
Sbjct: 319 PFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
Score = 38.1 bits (87), Expect = 0.012
Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 15/113 (13%)
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGV 309
++G+L K G + K WK R F+L + + + KE P G L V ++D
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKE---PRGIIPLENLSVQKVDDPKK 318
Query: 310 PTGVK---GNVQGNLFK---------VITKDDTHYYIQASSKAERAEWIEAIK 350
P ++ + +G K V+ Y I A+S ER +WIE+I+
Sbjct: 319 PFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIR 371
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 46.2 bits (108), Expect = 4e-05
Identities = 37/116 (31%), Positives = 53/116 (45%), Gaps = 22/116 (18%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTI-------T 59
+EG+L+K G V WK RWFIL N L Y++ + P+G I L+ +I
Sbjct: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIREVDDPRK 318
Query: 60 CPCLEY---ENRPLLIK-LKTQTSTE--------YFLEACSREERDAWAFEITGAI 103
C E N+ LIK KT+ Y + A ++EE+D W I A+
Sbjct: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 374
Score = 40.4 bits (93), Expect = 0.002
Identities = 42/161 (26%), Positives = 68/161 (42%), Gaps = 20/161 (12%)
Query: 202 GAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKR 261
G GDL E+ L + LY + KI + L+ + ++G+L K G +
Sbjct: 219 GINEGGDLPEELLRN---LYDSIRNEPFKIPEDDGNDLTHTFFNPD--REGWLLKLGGRV 273
Query: 262 KNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVK---GNVQ 318
K WK R F+L + + Y KE P G L + ++D P + N +
Sbjct: 274 KTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIREVDDPRKPNCFELYIPNNK 330
Query: 319 GNLFK---------VITKDDTHYYIQASSKAERAEWIEAIK 350
G L K V+ + Y I A ++ E+ EWI++I+
Sbjct: 331 GQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQ 371
>gi|189571664 DEP domain containing 6 [Homo sapiens]
Length = 409
Score = 45.1 bits (105), Expect = 1e-04
Identities = 42/157 (26%), Positives = 67/157 (42%), Gaps = 26/157 (16%)
Query: 131 RIVDK-MHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLME 189
R+ +K M NT ++ P E+G Y++TF+ S +DWL+ +R EA L LME
Sbjct: 138 RLYEKLMSPENTLLQ--PREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLME 195
Query: 190 ENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVV 249
++ V + F+ DS LY F +++++ E ++ + T
Sbjct: 196 HGIIQHVSNK-----------HPFV-DSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHD 243
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKE 286
L KQ H RK +F+ PSKE
Sbjct: 244 SPFCLRKQSHDN----------RKSTSFMS-VSPSKE 269
Score = 31.2 bits (69), Expect = 1.5
Identities = 26/112 (23%), Positives = 43/112 (38%), Gaps = 9/112 (8%)
Query: 154 TYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLMEENFLRPV--------GVRSMGAIR 205
TY F+ L+DWLI + + R A+ L L + + V V+ R
Sbjct: 59 TYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFR 118
Query: 206 SGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQ 257
D ++ A Y+K +SP E L E G ++ ++A +
Sbjct: 119 KDDGTFPLDNEVKAFMRGQRLYEKLMSP-ENTLLQPREEEGVKYERTFMASE 169
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 45.1 bits (105), Expect = 1e-04
Identities = 27/84 (32%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLEYE 66
+EG+L+K G V WK RWFIL N L Y++ + P+G I L+ +I +E
Sbjct: 263 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIR--EVEDS 317
Query: 67 NRPLLIKLKTQTSTEYFLEACSRE 90
+P +L + + ++AC E
Sbjct: 318 KKPNCFELYIPDNKDQVIKACKTE 341
Score = 43.1 bits (100), Expect = 4e-04
Identities = 44/156 (28%), Positives = 68/156 (43%), Gaps = 20/156 (12%)
Query: 207 GDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKRKNWKV 266
GDL E+ L + LY ++ KI + L+ + ++G+L K G + K WK
Sbjct: 225 GDLPEELLRN---LYESIKNEPFKIPEDDGNDLTHTFFNPD--REGWLLKLGGRVKTWKR 279
Query: 267 RRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKVI- 325
R F+L + + Y KE P G L + +ED+ P + + N +VI
Sbjct: 280 RWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIK 336
Query: 326 ---TKDD--------THYYIQASSKAERAEWIEAIK 350
T+ D T Y I A + E+ EWI+ IK
Sbjct: 337 ACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIK 372
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 13/115 (11%)
Query: 6 LKEGFLVKRGH-----IVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC 60
LK+G+L K+G NWK RWF+LRQ+ L+Y++ + ++ KG + +
Sbjct: 1214 LKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKL---KGTVEVRTAKEII 1270
Query: 61 PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLH 115
EN +I + L A S E+ W F + +HA ++Q++H
Sbjct: 1271 DNTTKENGIDII----MADRTFHLIAESPEDASQW-FSVLSQVHASTDQEIQEMH 1320
Score = 35.4 bits (80), Expect = 0.078
Identities = 28/109 (25%), Positives = 48/109 (44%), Gaps = 19/109 (17%)
Query: 249 VKQGYLAKQGH-----KRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSA 303
+KQG+L K+G R+NWK R FVLR+ L Y++ EE L
Sbjct: 1214 LKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSK--LMYFENDSEE-----------KLKGT 1260
Query: 304 LEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKL 352
+E + + N +I D T +++ A S + ++W + ++
Sbjct: 1261 VEVRTAKEIIDNTTKENGIDIIMADRT-FHLIAESPEDASQWFSVLSQV 1308
Score = 31.6 bits (70), Expect = 1.1
Identities = 9/28 (32%), Positives = 20/28 (71%)
Query: 10 FLVKRGHIVHNWKARWFILRQNTLVYYK 37
FL +G ++++WK RW +L+ T ++++
Sbjct: 1181 FLYMKGGLMNSWKRRWCVLKDETFLWFR 1208
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 43.9 bits (102), Expect = 2e-04
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 9 GFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLEYENR 68
GFL K+G + RWF+LR N L Y++ R P G I+L+GCT+ E
Sbjct: 22 GFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASRE---PVGVIILEGCTVEL-VEAAEEF 77
Query: 69 PLLIKLKTQTSTEYFLEACSREERDAWAFEITGA 102
++ + Y L A S++ + W ++ A
Sbjct: 78 AFAVRFAGTRARTYVLAAESQDAMEGWVKALSRA 111
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 43.5 bits (101), Expect = 3e-04
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLEYE 66
+EG+L+K G V WK RWFIL N L Y++ + P+G I L+ +I +E
Sbjct: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIR--EVEDP 321
Query: 67 NRPLLIKLKTQTSTEYFLEACSRE 90
+P +L + ++AC E
Sbjct: 322 RKPNCFELYNPSHKGQVIKACKTE 345
Score = 41.6 bits (96), Expect = 0.001
Identities = 61/260 (23%), Positives = 102/260 (39%), Gaps = 49/260 (18%)
Query: 111 VQQLHSLRNSFKLPPHISLHRIVDKMHDS--------NTGIRSSPNMEQGSTYKKTFLGS 162
VQ L SF+LP +D+M ++ N G+ S + ++ L +
Sbjct: 146 VQALRQFLWSFRLPGEAQK---IDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNT 202
Query: 163 SLVDWLISNSFTASRLEAVTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYT 222
SL + + + TA R A+ + G GDL E+ L + LY
Sbjct: 203 SLHNHNVRDKPTAERFIAM------------------NRGINEGGDLPEELLRN---LYE 241
Query: 223 FAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYD 282
++ KI + L+ + ++G+L K G + K WK R F+L + + Y
Sbjct: 242 SIKNEPFKIPEDDGNDLTHTFFNPD--REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYT 299
Query: 283 PSKEENRPVGGFSLRGSLVSALEDNGVPTGVK---GNVQGNLFK---------VITKDDT 330
KE P G L + +ED P + + +G + K V+ +
Sbjct: 300 TDKE---PRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHV 356
Query: 331 HYYIQASSKAERAEWIEAIK 350
Y I A S E+ EW+++IK
Sbjct: 357 VYRISAPSPEEKEEWMKSIK 376
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 42.4 bits (98), Expect = 6e-04
Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 16/109 (14%)
Query: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
+VK+GYL K+G K K WK F+L A L Y++ K +P G L V + D+
Sbjct: 475 IVKKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDS 533
Query: 308 --GVPTGVKGNVQGNLFKVITK--DDTHY--YIQASSKAERAEWIEAIK 350
G P N F+++ + + HY Y + + +W++ ++
Sbjct: 534 LFGRP---------NCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 573
Score = 37.4 bits (85), Expect = 0.020
Identities = 25/95 (26%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLE 64
++K+G+L+K+G WK +FIL + E +R T PKG I L C++
Sbjct: 475 IVKKGYLLKKGK-GKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDS 533
Query: 65 YENRPLLIKLKTQTSTE----YFLEACSREERDAW 95
RP ++ Q +E ++ + E+ + W
Sbjct: 534 LFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDW 568
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 42.4 bits (98), Expect = 6e-04
Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 16/109 (14%)
Query: 248 VVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDN 307
+VK+GYL K+G K K WK F+L A L Y++ K +P G L V + D+
Sbjct: 298 IVKKGYLLKKG-KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDS 356
Query: 308 --GVPTGVKGNVQGNLFKVITK--DDTHY--YIQASSKAERAEWIEAIK 350
G P N F+++ + + HY Y + + +W++ ++
Sbjct: 357 LFGRP---------NCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 396
Score = 37.4 bits (85), Expect = 0.020
Identities = 25/95 (26%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLE 64
++K+G+L+K+G WK +FIL + E +R T PKG I L C++
Sbjct: 298 IVKKGYLLKKGK-GKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDS 356
Query: 65 YENRPLLIKLKTQTSTE----YFLEACSREERDAW 95
RP ++ Q +E ++ + E+ + W
Sbjct: 357 LFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDW 391
>gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens]
Length = 589
Score = 42.0 bits (97), Expect = 8e-04
Identities = 37/142 (26%), Positives = 58/142 (40%), Gaps = 17/142 (11%)
Query: 217 STALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKRKN---WKVRRFVLRK 273
ST + AE + K + + + + G V K GYL K+G + W +R ++ K
Sbjct: 24 STISFMAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHK 83
Query: 274 DPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKV----ITKDD 329
YY S P G FSL G N V + N+F I+K
Sbjct: 84 RCV---YYFKSSTSASPQGAFSLSGY-------NRVMRAAEETTSNNVFPFKIIHISKKH 133
Query: 330 THYYIQASSKAERAEWIEAIKK 351
++ ASS+ ER W+ +++
Sbjct: 134 RTWFFSASSEEERKSWMALLRR 155
Score = 32.7 bits (73), Expect = 0.50
Identities = 26/102 (25%), Positives = 40/102 (39%), Gaps = 10/102 (9%)
Query: 1 MEDGVLKEGFLVKRGHI---VHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCT 57
M GV K G+L K+G + W R+ I+ + + Y+K P+G L G
Sbjct: 51 MPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCVYYFKSSTS---ASPQGAFSLSGYN 107
Query: 58 ITCPCLEYENRPLLIKLK----TQTSTEYFLEACSREERDAW 95
E + K ++ +F A S EER +W
Sbjct: 108 RVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSW 149
>gi|224586880 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 3 [Homo sapiens]
Length = 1257
Score = 42.0 bits (97), Expect = 8e-04
Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 2 EDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGC 56
+DG K G+L KR W+ +WF L QN L Y++ + R P G LL+GC
Sbjct: 21 KDGTRK-GYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSSR---PSGLYLLEGC 71
Score = 29.6 bits (65), Expect = 4.3
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 3/49 (6%)
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRG 298
++GYL+K+ W+ + F L ++ L +Y S +RP G + L G
Sbjct: 25 RKGYLSKRSSDNTKWQTKWFALLQN---LLFYFESDSSSRPSGLYLLEG 70
>gi|24797099 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 1 [Homo sapiens]
Length = 1273
Score = 42.0 bits (97), Expect = 8e-04
Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 2 EDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGC 56
+DG K G+L KR W+ +WF L QN L Y++ + R P G LL+GC
Sbjct: 21 KDGTRK-GYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSSR---PSGLYLLEGC 71
Score = 29.6 bits (65), Expect = 4.3
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 3/49 (6%)
Query: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRG 298
++GYL+K+ W+ + F L ++ L +Y S +RP G + L G
Sbjct: 25 RKGYLSKRSSDNTKWQTKWFALLQN---LLFYFESDSSSRPSGLYLLEG 70
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 247 TVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEEN--RPVGGFSLRGSLVSAL 304
T+VK+G++ K+G KNW+ R F+L+ D +F+ Y + ++ + P+ FS+ +
Sbjct: 5 TIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKT 64
Query: 305 EDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
E T + +Q + + + H + ER EW EAI+
Sbjct: 65 ERPKPNTFIIRCLQ---WTTVIERTFH----VDTPEEREEWTEAIQ 103
Score = 35.0 bits (79), Expect = 0.10
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILR-QNTLVYYKLEGGRRVTP-PKGRILLDGCTITCPC 62
++KEG++ KRG + NW+ R+F+L+ + + YK + P P + C +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 63 LEYENRPLLIKLKTQTSTEYFLEACSREERDAW 95
N ++ L+ T E + EER+ W
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEW 98
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 247 TVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEEN--RPVGGFSLRGSLVSAL 304
T+VK+G++ K+G KNW+ R F+L+ D +F+ Y + ++ + P+ FS+ +
Sbjct: 5 TIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKT 64
Query: 305 EDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIK 350
E T + +Q + + + H + ER EW EAI+
Sbjct: 65 ERPKPNTFIIRCLQ---WTTVIERTFH----VDTPEEREEWTEAIQ 103
Score = 35.0 bits (79), Expect = 0.10
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 5 VLKEGFLVKRGHIVHNWKARWFILR-QNTLVYYKLEGGRRVTP-PKGRILLDGCTITCPC 62
++KEG++ KRG + NW+ R+F+L+ + + YK + P P + C +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 63 LEYENRPLLIKLKTQTSTEYFLEACSREERDAW 95
N ++ L+ T E + EER+ W
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEW 98
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 41.6 bits (96), Expect = 0.001
Identities = 37/117 (31%), Positives = 53/117 (45%), Gaps = 23/117 (19%)
Query: 7 KEGFLVKRGH-IVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTI------- 58
+EG+L+K G V WK RWFIL N L Y++ + P+G I L+ +I
Sbjct: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIREVDDPR 318
Query: 59 TCPCLEY---ENRPLLIK-LKTQTSTE--------YFLEACSREERDAWAFEITGAI 103
C E N+ LIK KT+ Y + A ++EE+D W I A+
Sbjct: 319 KPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 375
Score = 37.4 bits (85), Expect = 0.020
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 202 GAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKR 261
G GDL E+ L + LY + KI + L+ + ++G+L K G R
Sbjct: 219 GINEGGDLPEELLRN---LYDSIRNEPFKIPEDDGNDLTHTFFNPD--REGWLLKLGGGR 273
Query: 262 -KNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVK---GNV 317
K WK R F+L + + Y KE P G L + ++D P + N
Sbjct: 274 VKTWKRRWFILTDNCLYYFEYTTDKE---PRGIIPLENLSIREVDDPRKPNCFELYIPNN 330
Query: 318 QGNLFK---------VITKDDTHYYIQASSKAERAEWIEAIK 350
+G L K V+ + Y I A ++ E+ EWI++I+
Sbjct: 331 KGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQ 372
>gi|38505170 Ras protein-specific guanine nucleotide-releasing
factor 2 [Homo sapiens]
Length = 1237
Score = 41.6 bits (96), Expect = 0.001
Identities = 20/51 (39%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 7 KEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCT 57
K GFL K+ W +WF L QN L Y++ G + P G LL+GC+
Sbjct: 25 KRGFLSKKTAEASRWHEKWFALYQNVLFYFE---GEQSCRPAGMYLLEGCS 72
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,378,668
Number of Sequences: 37866
Number of extensions: 585898
Number of successful extensions: 1600
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 1369
Number of HSP's gapped (non-prelim): 295
length of query: 353
length of database: 18,247,518
effective HSP length: 103
effective length of query: 250
effective length of database: 14,347,320
effective search space: 3586830000
effective search space used: 3586830000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.