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Search of human proteins with 13904858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13904858 cytochrome P450, family 19 [Homo sapiens]
(503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13904858 cytochrome P450, family 19 [Homo sapiens] 1015 0.0
gi|13904860 cytochrome P450, family 19 [Homo sapiens] 1015 0.0
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 100 2e-21
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 98 2e-20
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 97 4e-20
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 97 4e-20
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 94 4e-19
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 93 6e-19
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 91 2e-18
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 91 2e-18
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 90 4e-18
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 90 4e-18
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 89 7e-18
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 89 7e-18
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 89 1e-17
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 87 4e-17
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 84 3e-16
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 81 2e-15
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 81 3e-15
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 81 3e-15
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 80 3e-15
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 80 3e-15
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 80 4e-15
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 80 4e-15
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 79 7e-15
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 79 1e-14
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 79 1e-14
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 78 2e-14
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 77 3e-14
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 77 3e-14
>gi|13904858 cytochrome P450, family 19 [Homo sapiens]
Length = 503
Score = 1015 bits (2625), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
Query: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
Query: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360
Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480
Query: 481 PDETKNMLEMIFTPRNSDRCLEH 503
PDETKNMLEMIFTPRNSDRCLEH
Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503
>gi|13904860 cytochrome P450, family 19 [Homo sapiens]
Length = 503
Score = 1015 bits (2625), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
Query: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
Query: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360
Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480
Query: 481 PDETKNMLEMIFTPRNSDRCLEH 503
PDETKNMLEMIFTPRNSDRCLEH
Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 100 bits (250), Expect = 2e-21
Identities = 109/474 (22%), Positives = 210/474 (44%), Gaps = 40/474 (8%)
Query: 19 EAMPAATMPVLLLTGLFLLVWNYEGTSS--------IPGPGYCMGIGPLISHGRFLWMGI 70
+ +P M +L L++ GT S IPGP +G ++ + R LW
Sbjct: 2 DLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLW-NF 60
Query: 71 GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK 130
CN YGE ++ G++ +++ M + S F +++ L +G +
Sbjct: 61 DRECN---EKYGEMWGLY-EGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKS 116
Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190
+ F + E WK R A + MV + ++ + L + S +++
Sbjct: 117 ALSFAEDEE-WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDF 175
Query: 191 LRRVMLDT-SNTLF------LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK 243
+D + TLF L P D +K D L+ +F ++ +++
Sbjct: 176 FGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEA 235
Query: 244 YEKSV--KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTR-------E 294
+ KD+ ++ I E+ + ++K + +DF ++I ++ + E
Sbjct: 236 LNIGLFPKDVTHFLKNSI-ERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLE 294
Query: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI-GERDIKIDDIQKL 353
V Q I+ ++ AA DT S +L F+++ +A HP+V++ + +EI V+ + + D + ++
Sbjct: 295 LVAQSII-IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353
Query: 354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNE 412
+ ++ + E++R PVV V R +D I+G + KG +++ I +H +++ +P +
Sbjct: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEK 413
Query: 413 FTLENFAKNVP-----YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461
F E F+K YRY PFG GPR C G A+ +K ++ L+ F K
Sbjct: 414 FCPERFSKKNKDSIDLYRYI-PFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 98.2 bits (243), Expect = 2e-20
Identities = 72/254 (28%), Positives = 123/254 (48%), Gaps = 27/254 (10%)
Query: 233 IFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE--------------KLEECMDF 278
+ FK W +KK S++ L +IAE+ ++ E K +D
Sbjct: 246 LMFKEGWEHKK---SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDL 302
Query: 279 ATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQT 338
+ ++ L+ E++ + + + DT + ++ + L+L+ +P V++ + E+
Sbjct: 303 LLS-VTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361
Query: 339 VIGERD--IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIIL 396
V G+ D ++D++KL+ +E I E++R P V L R ED + GY V KGT ++
Sbjct: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421
Query: 397 NIGRMHR-LEFFPKPNEFTLEN-FAKNV----PYRYFQPFGFGPRGCAGKYIAMVMMKAI 450
+HR +FP P EF E F +N PY Y PF GPR C G+ A++ K I
Sbjct: 422 IPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYV-PFSAGPRNCIGQKFAVMEEKTI 480
Query: 451 LVTLLRRFHVKTLQ 464
L +LR F +++ Q
Sbjct: 481 LSCILRHFWIESNQ 494
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 96.7 bits (239), Expect = 4e-20
Identities = 91/378 (24%), Positives = 167/378 (44%), Gaps = 33/378 (8%)
Query: 112 YSSRFGSKLGLQCIGMH-EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170
Y F + L H ++GIIFNN P WK R F + L G+ + +
Sbjct: 93 YKDEFSGRGDLPAFHAHRDRGIIFNNGPT-WKDIRRFSLTTLRNYGMGKQGNESRIQREA 151
Query: 171 HLDRLEEVTNESGYVD-------------VLTLLRRVMLDTSNTLFLRIP--LDESAIVV 215
H LE + G + +L R D ++ FLR+ +E+ ++
Sbjct: 152 HF-LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210
Query: 216 KIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTE--EKL 272
W L P + ++K K+V ++K+ + + E + + L
Sbjct: 211 STP-----WLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 265
Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332
+C+ E T + + + ++ A +T S +L + L ++ K+P +EE +
Sbjct: 266 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325
Query: 333 IKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRYQPVV-DLVMRKALEDDVIDGYPVKK 390
+EI VIG I I D Q++ M+ ++E R+ +V + +A D + GY + K
Sbjct: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385
Query: 391 GTNIILNIGR-MHRLEFFPKPNEFTLENFA-KNVPYR---YFQPFGFGPRGCAGKYIAMV 445
GT ++ + ++ + FP P +F E+F +N ++ YF+PF G R CAG+ +A +
Sbjct: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445
Query: 446 MMKAILVTLLRRFHVKTL 463
+ +L +L+ F++K L
Sbjct: 446 ELFLLLCAILQHFNLKPL 463
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 96.7 bits (239), Expect = 4e-20
Identities = 109/475 (22%), Positives = 211/475 (44%), Gaps = 41/475 (8%)
Query: 19 EAMPAATMPVLLLTGLFLLVWNYEGTSS--------IPGPGYCMGIGPLISHGRFLWMGI 70
+ +P M +L L++ GT S IPGP +G ++ + R LW
Sbjct: 2 DLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLW-NF 60
Query: 71 GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK 130
CN YGE ++ G++ +++ M + S F +++ L +G +
Sbjct: 61 DRECN---EKYGEMWGLY-EGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKS 116
Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190
+ F + E WK R A + MV + ++ + L + S +++
Sbjct: 117 ALSFAEDEE-WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDF 175
Query: 191 LRRVMLDT-SNTLF------LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK 243
+D + TLF L P D +K D L+ +F ++ +++
Sbjct: 176 FGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEA 235
Query: 244 YEKSV--KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTR-------E 294
+ KD+ ++ I E+ + ++K + +DF ++I ++ + E
Sbjct: 236 LNIGLFPKDVTHFLKNSI-ERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLE 294
Query: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI-GERDIKIDDIQKL 353
V Q I+ ++ AA DT S +L F+++ +A HP+V++ + +EI V+ + + D + ++
Sbjct: 295 LVAQSII-IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353
Query: 354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNE 412
+ ++ + E++R PVV V R +D I+G + KG +++ I +H +++ +P +
Sbjct: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEK 413
Query: 413 FTLEN-FAKNVP-----YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461
F E+ F+K YRY PFG GPR C G A+ +K ++ L+ F K
Sbjct: 414 FCPESRFSKKNKDSIDLYRYI-PFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 467
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 93.6 bits (231), Expect = 4e-19
Identities = 58/179 (32%), Positives = 98/179 (54%), Gaps = 7/179 (3%)
Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDD 349
LT + + + EML+A DT S +L + ++L+A+HP V++ + +EI +GER + D
Sbjct: 165 LTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAAD 224
Query: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIIL-NIGRMHRLEFFP 408
+ K+ ++ + E++R PV+ R ED VI GY + KGT + L + ++ E FP
Sbjct: 225 VPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
Query: 409 KPNEFTLENFAK-----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKT 462
+ EF E + + V PFG G R C G+ IA + + +++ LL+ F +KT
Sbjct: 285 RAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 92.8 bits (229), Expect = 6e-19
Identities = 83/358 (23%), Positives = 160/358 (44%), Gaps = 31/358 (8%)
Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE-SGYVDVL 188
+GI+ + + W R A L +T+ +S LD+ + + +E S +D+
Sbjct: 134 EGILLSGGDK-WSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMF 192
Query: 189 TLLRRVMLDTSNTLFLRI-------PLDESAIVVKIQGYFDAW-QALLIKPDIFFKISWL 240
+ + LD+ P + A ++++ + Q +L D + +S
Sbjct: 193 EHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHD 252
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTE--------EKLEECMDFATELILAEKRGD-- 290
+++ ++ + + D + +I E+RR + T+ + + +DF L+L++
Sbjct: 253 GRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKA 312
Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD---IKI 347
L+ E++ + DT + L ++L+ +A+HP +E +E+Q ++ +RD I+
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
Query: 348 DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI-DGYPVKKGTNIILNI-GRMHRLE 405
DD+ +L + + ES+R P + R +D V+ DG + KG +++I G H
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432
Query: 406 FFPKPN-----EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
+P P F EN P + PF GPR C G+ AM MK +L +L F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRSPLAFI-PFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 90.9 bits (224), Expect = 2e-18
Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 25/272 (9%)
Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267
L+ SA+V K Q +L+ D + ++ +++ ++ + + D + +I E+RR +
Sbjct: 226 LELSALVTKRH------QQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLP 279
Query: 268 TE--------EKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSLFF 317
++ + + +DF L+L+ E L+ E++ + DT + L +
Sbjct: 280 SQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSW 339
Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERD---IKIDDIQKLKVMENFIYESMRYQPVVDLVM 374
+L+ +AKHP +E +E+Q ++ +R+ I+ DD+ +L + I ES+R P V V
Sbjct: 340 VLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVS 399
Query: 375 RKALEDDVI-DGYPVKKGTNIILNI-GRMHRLEFFPKPNEFTLENF-AKNVPYRY---FQ 428
R +D V+ DG + KG ++++ G H +P P + F KN+ R F
Sbjct: 400 RCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459
Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
PF GPR C G+ AM MK +L L RF V
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRV 491
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 90.9 bits (224), Expect = 2e-18
Identities = 69/273 (25%), Positives = 132/273 (48%), Gaps = 27/273 (9%)
Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267
++ SA+VVK F ++ D + ++ +++ ++ + + D + +I E+RR ++
Sbjct: 226 MELSALVVKRNNQFFRYK------DFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLT 279
Query: 268 TE--------EKLEECMDFATELILAEKRG--DLTRENVNQCILEMLIAAPDTMSVSLFF 317
++ + + +DF L+L+E + +L+ E++ + DT + L +
Sbjct: 280 SQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSW 339
Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERD---IKIDDIQKLKVMENFIYESMRYQPVVDLVM 374
+L+ +A+HP +E +E+Q ++ +R+ I+ DD+ +L + + ES+R P +
Sbjct: 340 VLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFA 399
Query: 375 RKALEDDVI-DGYPVKKGTNIILNIGRMHRL-EFFPKPN-----EFTLENFAKNVPYRYF 427
R +D V+ D + KG +NI +H +P P F EN K P +
Sbjct: 400 RGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFI 459
Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
PF GPR C G+ AM MK +L L RF +
Sbjct: 460 -PFSAGPRNCIGQKFAMAEMKVVLALTLLRFRI 491
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 90.1 bits (222), Expect = 4e-18
Identities = 96/456 (21%), Positives = 213/456 (46%), Gaps = 38/456 (8%)
Query: 42 EGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNY-----YNRVYGEFMRVWISGEETLI 96
+ +++PGP +G L+ + LW G G + Y++ YG+ R+ + E++
Sbjct: 53 QNAAALPGPTSWPLLGSLL---QILWKG-GLKKQHDTLVEYHKKYGKIFRMKLGSFESVH 108
Query: 97 ISKSSSMFHIMK-HNHYSSRFGSKLGLQCIGMHEKGI-IFNNNPELWKTTRPFFMKALSG 154
+ + + + + Y R K ++G + E W+ R F K L
Sbjct: 109 LGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMK 168
Query: 155 PG-LVRMVTVCAESLKTHLDRLEEVTNESGYV-DVLTLLRR--------VMLDTSNTLFL 204
PG ++++ E L + R++E+ +E G+V D+ + L + V+ + L
Sbjct: 169 PGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQ 228
Query: 205 RIPLDESA-IVVKIQGYFDAWQALLIKPDIFFKI--SWLYKKYEKSVKDLKDAIEVLIAE 261
+ DE+ ++ I+ + +++ P K + +++ + + + +++ I
Sbjct: 229 KNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDN 288
Query: 262 KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFL 321
+ + S + + D I + R L+++ + + E+ +AA +T + SL ++L+
Sbjct: 289 RLEKYSQQPSADFLCD-----IYHQNR--LSKKELYAAVTELQLAAVETTANSLMWILYN 341
Query: 322 IAKHPNVEEAIIKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380
++++P V++ ++KEIQ+V+ E + + +D++ + ++ + ESMR P V R +
Sbjct: 342 LSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKA 401
Query: 381 DVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFT----LENFAKNVPYRYFQPFGFGPR 435
V+ Y + KGT ++LN + E F ++F L+ K P+ + PFG G R
Sbjct: 402 TVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHL-PFGVGKR 460
Query: 436 GCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471
C G+ +A + + L ++R++ ++ + VE +
Sbjct: 461 MCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEML 496
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 90.1 bits (222), Expect = 4e-18
Identities = 68/255 (26%), Positives = 123/255 (48%), Gaps = 27/255 (10%)
Query: 232 DIFFKISWLY------KKYEKSVKDLKDAIEVLIAEKRRRISTE--------EKLEECMD 277
+I I +LY +++ ++ + + D + +I E+RR + ++ + + +D
Sbjct: 238 EILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD 297
Query: 278 FATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335
F L+L+ E L+ E++ + DT + L ++L+ +AKHP +E +E
Sbjct: 298 FIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQE 357
Query: 336 IQTVIGERD---IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI-DGYPVKKG 391
+Q ++ +R+ I+ DD+ L + + ES+R P V ++ R +D V+ DG + KG
Sbjct: 358 VQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKG 417
Query: 392 TNIILNI-GRMHRLEFFPKPN-----EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMV 445
++++ G H +P P F EN + P + PF GPR C G+ AM
Sbjct: 418 IICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI-PFSAGPRNCIGQTFAMA 476
Query: 446 MMKAILVTLLRRFHV 460
MK +L L RF V
Sbjct: 477 EMKVVLALTLLRFRV 491
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 89.4 bits (220), Expect = 7e-18
Identities = 69/275 (25%), Positives = 133/275 (48%), Gaps = 22/275 (8%)
Query: 207 PLDESAIVVKIQGYFDAW-QALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR 265
P + A ++++ + + Q +L+ D + ++ +++ ++ + D + +I E+R
Sbjct: 218 PSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCT 277
Query: 266 ISTE--------EKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSL 315
+ T+ + + +DF L+L+ E +L+ E++ + DT + L
Sbjct: 278 LPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGL 337
Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERD---IKIDDIQKLKVMENFIYESMRYQPVVDL 372
++L+ +AKHP +E +E+Q ++ +R+ I+ DD+ +L + I ES+R P V +
Sbjct: 338 SWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPV 397
Query: 373 VMRKALEDDVI-DGYPVKKGTNIILNIGRMH-RLEFFPKPN-----EFTLENFAKNVPYR 425
+ R +D V+ DG + KG ++NI +H +P P F EN + P
Sbjct: 398 ISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLA 457
Query: 426 YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
+ PF GPR C G+ AM MK +L L F +
Sbjct: 458 FI-PFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 89.4 bits (220), Expect = 7e-18
Identities = 69/275 (25%), Positives = 133/275 (48%), Gaps = 22/275 (8%)
Query: 207 PLDESAIVVKIQGYFDAW-QALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR 265
P + A ++++ + + Q +L+ D + ++ +++ ++ + D + +I E+R
Sbjct: 218 PSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCT 277
Query: 266 ISTE--------EKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSL 315
+ T+ + + +DF L+L+ E +L+ E++ + DT + L
Sbjct: 278 LPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGL 337
Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERD---IKIDDIQKLKVMENFIYESMRYQPVVDL 372
++L+ +AKHP +E +E+Q ++ +R+ I+ DD+ +L + I ES+R P V +
Sbjct: 338 SWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPV 397
Query: 373 VMRKALEDDVI-DGYPVKKGTNIILNIGRMH-RLEFFPKPN-----EFTLENFAKNVPYR 425
+ R +D V+ DG + KG ++NI +H +P P F EN + P
Sbjct: 398 ISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLA 457
Query: 426 YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
+ PF GPR C G+ AM MK +L L F +
Sbjct: 458 FI-PFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 88.6 bits (218), Expect = 1e-17
Identities = 93/409 (22%), Positives = 177/409 (43%), Gaps = 36/409 (8%)
Query: 81 YGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI---GMHEKGIIFNNN 137
YG +RV + + ++I++ S+ + Y+ LQ + + +G++ N
Sbjct: 71 YGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130
Query: 138 PELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLD 197
E W R A S LV ++ E + ++ LE + V + +L +D
Sbjct: 131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190
Query: 198 ----------TSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKS 247
TS L + PL + A+ + ++G + L +L K K
Sbjct: 191 ILAKAAFGMETSMLLGAQKPLSQ-AVKLMLEGITASRNTLA---------KFLPGK-RKQ 239
Query: 248 VKDLKDAIEVLIAE-----KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILE 302
+++++++I L +RRR + + E D T+++ AE+ G E + +
Sbjct: 240 LREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLDNFVT 298
Query: 303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIY 361
IA +T + L F + +++ P + + E+ VIG +R + +D+ +L+ + +
Sbjct: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358
Query: 362 ESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAK 420
ES+R P R E+ +IDG V T ++ + M R++ +F P F + F
Sbjct: 359 ESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418
Query: 421 NVP---YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466
P + YF PF G R C G+ A + +K ++ LL+R + + GQ
Sbjct: 419 GAPKPRFTYF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 87.0 bits (214), Expect = 4e-17
Identities = 107/478 (22%), Positives = 207/478 (43%), Gaps = 49/478 (10%)
Query: 19 EAMPAATMPVLLLTGLFLLVWNYEGTSS--------IPGPGYCMGIGPLISHGRFLWMGI 70
+ +P + LL + L++ GT + IPGP +G ++S+ + LW
Sbjct: 2 DLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFD 61
Query: 71 GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK 130
Y +++G + G+ ++ + + S F ++ L +G +
Sbjct: 62 TECYKKYGKMWGTY-----EGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS 116
Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE-------SLKTHLDRLEEVTNESG 183
I + E WK R + L M + A+ +L+ ++ + VT +
Sbjct: 117 AISLAEDEE-WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175
Query: 184 Y----VDVLTLLR-RVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKIS 238
+ +DV+T V +D+ N + P ES G+ D L + +F ++
Sbjct: 176 FGAYSMDVITGTSFGVNIDSLNNP--QDPFVESTKKFLKFGFLDP---LFLSIILFPFLT 230
Query: 239 WLYKKYEKSVKDLKDAIEVLI--AEKRRRISTEEKLEECMDFATELILAEKRGDLTRENV 296
+++ S+ KD I L + ++ +K + +DF +L++ + T +
Sbjct: 231 PVFEALNVSLFP-KDTINFLSKSVNRMKKSRLNDKQKHRLDFL-QLMIDSQNSKETESHK 288
Query: 297 NQCILEM-------LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKID 348
LE+ + A +T S L F L+ +A HP+V++ + KEI V+ + D
Sbjct: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348
Query: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFF 407
+ +++ ++ + E++R PV + R +D I+G + KG+ +++ +H +++
Sbjct: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408
Query: 408 PKPNEFTLENFAKNV----PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461
+P EF E F+K PY Y PFG GPR C G A++ MK L+ +L+ F K
Sbjct: 409 TEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 84.0 bits (206), Expect = 3e-16
Identities = 114/484 (23%), Positives = 208/484 (42%), Gaps = 60/484 (12%)
Query: 19 EAMPAATMPVLLLTGLFLLVWNYEGTSS--------IPGPGYCMGIGPLISHGRFLWMGI 70
+ +P + LL + L++ GT + IPGP +G +S + W
Sbjct: 2 DLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFD 61
Query: 71 GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK 130
Y +V+G ++ + L I+ + ++ YS F ++ +G +
Sbjct: 62 MECYKKYRKVWG----IYDCQQPMLAITDPDMIKTVLVKECYSV-FTNRRPFGPVGFMKN 116
Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE-------SLKTHLDRLEEVTNESG 183
I + E WK R + L MV + A+ +L+ + + VT +
Sbjct: 117 AISIAEDEE-WKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV 175
Query: 184 Y----VDVLTLLR-RVMLDTSNT-----------LFLRIPLDESAIVVKIQGYFDA-WQA 226
+ +DV+T V +D+ N L PLD + +K+ + +A
Sbjct: 176 FGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEA 235
Query: 227 LLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKL---EECMDFATELI 283
L I IS+L KSVK +K+ L ++ R+ + + + D T
Sbjct: 236 LNITVFPRKVISFL----TKSVKQIKEGR--LKETQKHRVDFLQLMIDSQNSKDSETHKA 289
Query: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER 343
L++ E + Q I+ + A +T S L F+++ +A HP+V++ + KEI TV+ +
Sbjct: 290 LSDL------ELMAQSII-FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
Query: 344 -DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402
D + +L+ ++ + E++R PV + R +D I+G + KG +++ +H
Sbjct: 343 APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLH 402
Query: 403 R-LEFFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457
+++ +P +F E F+K N+ + PFG GPR C G A+V MK LV +L+
Sbjct: 403 HDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQN 462
Query: 458 FHVK 461
F K
Sbjct: 463 FSFK 466
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 81.3 bits (199), Expect = 2e-15
Identities = 67/222 (30%), Positives = 107/222 (48%), Gaps = 20/222 (9%)
Query: 258 LIAEKRRRISTE-------EKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAP 308
+I E+RR + + K + +DF L+LA E +L+ E++ +
Sbjct: 278 VIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGH 337
Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER---DIKIDDIQKLKVMENFIYESMR 365
DT S + +MLF +AK+P +E +EIQ V+ R +++ DD+ +L I ES+R
Sbjct: 338 DTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLR 397
Query: 366 YQPVVDLVMRKALED-DVIDGYPVKKGTNIILNI-GRMHRLEFFP-----KPNEFTLENF 418
P V LV R+ ED + DG + KG +++I G H +P P F +N
Sbjct: 398 QYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNP 457
Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
+ P Y PF GPR C G+ AM ++ ++ L RF +
Sbjct: 458 QQRSPLAYV-PFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 80.9 bits (198), Expect = 3e-15
Identities = 60/228 (26%), Positives = 107/228 (46%), Gaps = 9/228 (3%)
Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG--DLTRENVNQCILEM 303
K ++ L+D I + +R + + F + EK + +N+ L +
Sbjct: 188 KLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 247
Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYE 362
IA +T+S +L + L+ KHP VE + +EI VIG+ R K +D K+ ME I+E
Sbjct: 248 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 307
Query: 363 SMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK 420
R+ V+ + + R+ +D + + KGT + +G + R FF P +F ++F
Sbjct: 308 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 367
Query: 421 N----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464
+ F PF G R C G+ +A + + T+++ F +K+ Q
Sbjct: 368 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 415
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 80.9 bits (198), Expect = 3e-15
Identities = 60/228 (26%), Positives = 107/228 (46%), Gaps = 9/228 (3%)
Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG--DLTRENVNQCILEM 303
K ++ L+D I + +R + + F + EK + +N+ L +
Sbjct: 239 KLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 298
Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYE 362
IA +T+S +L + L+ KHP VE + +EI VIG+ R K +D K+ ME I+E
Sbjct: 299 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 358
Query: 363 SMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK 420
R+ V+ + + R+ +D + + KGT + +G + R FF P +F ++F
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418
Query: 421 N----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464
+ F PF G R C G+ +A + + T+++ F +K+ Q
Sbjct: 419 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/266 (24%), Positives = 122/266 (45%), Gaps = 32/266 (12%)
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
+++ +++ +++KD I ++R+ ++EK+++ + + + R LT + V +
Sbjct: 151 FRRRDRAHREIKDIFYKAIQKRRQ---SQEKIDDILQTLLDATYKDGR-PLTDDEVAGML 206
Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER--DIKIDDIQKLKVMEN 358
+ +L+A T S + +M F +A+ +++ E +TV GE + D ++ L +++
Sbjct: 207 IGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDR 266
Query: 359 FIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG--------TNIILNIGRMHRLEFFPKP 410
I E++R +P + ++MR A + GY + G N L + RL+F P
Sbjct: 267 CIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDF--NP 324
Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470
+ + +N A + Y PFG G C G+ A V +K I T+LR + + G
Sbjct: 325 DRYLQDNPASGEKFAYV-PFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYF--- 380
Query: 471 IQKIHDLSLHPDETKNMLEMIFTPRN 496
T N MI TP N
Sbjct: 381 ------------PTVNYTTMIHTPEN 394
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/266 (24%), Positives = 122/266 (45%), Gaps = 32/266 (12%)
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
+++ +++ +++KD I ++R+ ++EK+++ + + + R LT + V +
Sbjct: 256 FRRRDRAHREIKDIFYKAIQKRRQ---SQEKIDDILQTLLDATYKDGR-PLTDDEVAGML 311
Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER--DIKIDDIQKLKVMEN 358
+ +L+A T S + +M F +A+ +++ E +TV GE + D ++ L +++
Sbjct: 312 IGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDR 371
Query: 359 FIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG--------TNIILNIGRMHRLEFFPKP 410
I E++R +P + ++MR A + GY + G N L + RL+F P
Sbjct: 372 CIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDF--NP 429
Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470
+ + +N A + Y PFG G C G+ A V +K I T+LR + + G
Sbjct: 430 DRYLQDNPASGEKFAYV-PFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYF--- 485
Query: 471 IQKIHDLSLHPDETKNMLEMIFTPRN 496
T N MI TP N
Sbjct: 486 ------------PTVNYTTMIHTPEN 499
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 80.1 bits (196), Expect = 4e-15
Identities = 111/475 (23%), Positives = 197/475 (41%), Gaps = 46/475 (9%)
Query: 21 MPAATMPVLLLTGLFLLVWNYEGTSS--------IPGPGYCMGIGPLISHGRFLWMGIGS 72
+P M LL + L++ GT S IPGP +G ++S+ + M
Sbjct: 4 IPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDME 63
Query: 73 ACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGI 132
Y +V+G + G++ ++ M + S F ++ +G + I
Sbjct: 64 CHKKYGKVWGFY-----DGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAI 118
Query: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAES---LKTHLDRLEEVTNESGYVDVLT 189
+ E WK R + L MV + A+ L +L R E DV
Sbjct: 119 SIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG 177
Query: 190 LLRR-VMLDTS---NTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIF-FKISWLY--- 241
V+ TS N L P D K FD + +F F I L
Sbjct: 178 AYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLN 237
Query: 242 ---------KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLT 292
KSVK +K++ L ++ R+ + + + + + E + DL
Sbjct: 238 ICVFPREVTNFLRKSVKRMKESR--LEDTQKHRVDFLQLMIDSQN-SKETESHKALSDL- 293
Query: 293 RENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDIQ 351
E V Q I+ + A +T S L F+++ +A HP+V++ + +EI V+ + D +
Sbjct: 294 -ELVAQSII-FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351
Query: 352 KLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKP 410
+++ ++ + E++R P+ + R +D I+G + KG +++ +HR +++ +P
Sbjct: 352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP 411
Query: 411 NEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461
+F E F+K N+ + PFG GPR C G A++ MK L+ +L+ F K
Sbjct: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 80.1 bits (196), Expect = 4e-15
Identities = 98/416 (23%), Positives = 177/416 (42%), Gaps = 52/416 (12%)
Query: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNP 138
RVYG +I +++S S+ + ++ L I EKG++F +
Sbjct: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYG 171
Query: 139 ELWKTTRPFFMKALSGPGLVRMVT----------VCAESLKTHLDRLEEVTNESGYVD-- 186
+W+ R F L GL ++ V AE K D + S V
Sbjct: 172 PVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNI 231
Query: 187 VLTLLRRVMLDTSNTLF----------LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFK 236
+ +L D +N+ F L I L+ ++V I P +++
Sbjct: 232 ICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNIC------------PWLYYL 279
Query: 237 ISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELIL--AEKRGDLTRE 294
+K+ + KD+ ++ +I + + + E DF +L E+R + +
Sbjct: 280 PFGPFKELRQIEKDITSFLKKIIKDHQESLDRENP----QDFIDMYLLHMEEERKNNSNS 335
Query: 295 NVNQCIL-----EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKID 348
+ ++ L ++ IA DT + SL + L ++ +P+V+E + +EI+ VIG R +
Sbjct: 336 SFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLT 395
Query: 349 DIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEF 406
D ++ E I E R VV L + E+ V+ GY + KGT I+ N+ +HR
Sbjct: 396 DKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAI 455
Query: 407 FPKPNEF----TLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
+ KP +F L++ + + F PFG G R C G+ +A + + + V+L++ F
Sbjct: 456 WEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 79.3 bits (194), Expect = 7e-15
Identities = 52/176 (29%), Positives = 90/176 (51%), Gaps = 7/176 (3%)
Query: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDI 350
++EN+ + E++IA +T + L + + +A +PN++ + KEI ++G DD
Sbjct: 296 SKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK 355
Query: 351 QKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFP 408
K+ E ++E +R+ +V L + ED V+ GY + KGT +I N+ +H E ++
Sbjct: 356 CKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWR 415
Query: 409 KPNEFTLENFAKNVPY----RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
P F E F + Y PF G R C G+++A + M LL+RFH+
Sbjct: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/197 (28%), Positives = 97/197 (49%), Gaps = 7/197 (3%)
Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333
+C E ++ + EN+ + ++ +A +T S +L + L L+ KHP V +
Sbjct: 265 DCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQ 324
Query: 334 KEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKG 391
+EI VIG R + D + + ++E RY +V + A+ D Y + KG
Sbjct: 325 EEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKG 384
Query: 392 TNII-LNIGRMHRLEFFPKPNEFTLENFA-KNVPYR---YFQPFGFGPRGCAGKYIAMVM 446
T I+ L +H + FP PN F +F KN ++ YF PF G R CAG+ +A +
Sbjct: 385 TTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARME 444
Query: 447 MKAILVTLLRRFHVKTL 463
+ L T+L+ F++K++
Sbjct: 445 LFLFLTTILQNFNLKSV 461
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 78.6 bits (192), Expect = 1e-14
Identities = 76/332 (22%), Positives = 146/332 (43%), Gaps = 39/332 (11%)
Query: 161 VTVCAESLKTHLDRLEEV-TNESGYVDVLTLLRRVMLD----------------TSNTLF 203
+ V A S+K LD+ E++ + + V+V + + LD +++ +
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPY 212
Query: 204 LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKR 263
+ + S I+ F +LL DI FK+S +++K + L + +I E++
Sbjct: 213 AKAIFELSKII------FHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERK 266
Query: 264 RRISTEEKLEEC-----MDFATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSLF 316
+ + K + DF ++ A E + +V+ + L+A DT++ S+
Sbjct: 267 KSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASIS 326
Query: 317 FMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375
++L+ +A +P +E +E++ ++G+ I D + ++ I E+ R P V + R
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISR 386
Query: 376 KALEDDVI-DGYPVKKGTNIILNIGRMHRLEFFPK------PNEFTLENFAKNVPYRYFQ 428
+ DG + G ++L+I +H K P F+ EN + PY Y
Sbjct: 387 DLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL- 445
Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
PF G R C G+ AM+ +K + +L F V
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 77.8 bits (190), Expect = 2e-14
Identities = 107/482 (22%), Positives = 195/482 (40%), Gaps = 45/482 (9%)
Query: 29 LLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYN--RVYGEFMR 86
LLL L L W P + + PL+ FL N++ + YG
Sbjct: 7 LLLLTLAYLFWPKRRCPGAKYPKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYS 65
Query: 87 VWISGEETLIISKSSSMFHIM--KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTT 144
V + + T+I+ ++ K +S R L + KGI F ++ W+
Sbjct: 66 VRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR-PQMATLDIASNNRKGIAFADSGAHWQLH 124
Query: 145 RPFFMK--ALSGPGLVRMVTVCAESLKTHLDRLEEVTNES------GYVDVLTLLRRVML 196
R M AL G ++ + + + T D L +S +V V ++ +
Sbjct: 125 RRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICF 184
Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256
+TS + + IQ Y + L K + + WL K+++ LK ++
Sbjct: 185 NTSYK-------NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVK 237
Query: 257 VL------IAEKRRRISTEEKLEECMDFATELILAEKRGD---------LTRENVNQCIL 301
+ I E + + + +D + + G+ L+ ++ I
Sbjct: 238 IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIG 297
Query: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFI 360
++ A +T + + + L + +P V++ + +EI +G R I D +L ++E I
Sbjct: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATI 357
Query: 361 YESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENF 418
E +R +PV L+ KA D I + V KGT +I+N+ +H E + +P++F E F
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 419 AKNV------PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQ 472
P + PFG GPR C G+ +A + I+ LL+RF ++ + S++
Sbjct: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477
Query: 473 KI 474
I
Sbjct: 478 GI 479
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 77.4 bits (189), Expect = 3e-14
Identities = 58/226 (25%), Positives = 104/226 (46%), Gaps = 9/226 (3%)
Query: 248 VKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG--DLTRENVNQCILEMLI 305
++ L+D I + +R + + F + EK + +N+ L + I
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300
Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESM 364
+T+S +L + L+ KHP VE + +EI VIG+ R K +D K+ ME I+E
Sbjct: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360
Query: 365 RYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKN- 421
R+ V+ + + R+ +D + + KGT + +G + R FF P +F ++F
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420
Query: 422 ---VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464
F PF G R C G+ +A + + T+++ F +K+ Q
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 77.4 bits (189), Expect = 3e-14
Identities = 86/363 (23%), Positives = 158/363 (43%), Gaps = 33/363 (9%)
Query: 122 LQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE 181
LQ IG +G++ P+ W R L V V ES + LD+ EE E
Sbjct: 119 LQWIG---RGLLVLEGPK-WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 182 SGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPD---IFFK-- 236
D+ + + L+T + ++ + + Y+ A L + + F+
Sbjct: 175 GKSFDIFCDVGHMALNT--LMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232
Query: 237 ---ISWLY---KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEEC-----MDFATELILA 285
I WL +++ ++ + D + +I E++ + E+ ++ +DF L+ A
Sbjct: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGA 292
Query: 286 EKRGD--LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER 343
D L+ ++ + + DT + + + L+ +A +P + +E++ ++G++
Sbjct: 293 RDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ 352
Query: 344 DI-KIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED-DVIDGYPVKKGTNIILNIGRM 401
D + DD+ K+ + I ES R P V V R+ + +DG + G+ I ++I +
Sbjct: 353 DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 402 HRLE-FFPKPN-----EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455
HR +P P F+ EN +K P+ F PF GPR C G+ AM MK + L
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFA-FMPFSAGPRNCIGQQFAMSEMKVVTAMCL 471
Query: 456 RRF 458
RF
Sbjct: 472 LRF 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,292,286
Number of Sequences: 37866
Number of extensions: 784164
Number of successful extensions: 2670
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2518
Number of HSP's gapped (non-prelim): 86
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.