Search of human proteins with 13899275

Search of human proteins with 13899275

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13899275 cerebral cavernous malformation 2 isoform 2 [Homo
sapiens]
         (444 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13899275 cerebral cavernous malformation 2 isoform 2 [Homo sa...   877   0.0  
gi|71067341 cerebral cavernous malformation 2 isoform 1 [Homo sa...   857   0.0  
gi|31542255 hypothetical protein LOC140706 [Homo sapiens]             146   3e-35
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    32   1.5  
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    32   1.5  
gi|4557757 MutL protein homolog 1 [Homo sapiens]                       31   2.0  
gi|12383066 axotrophin [Homo sapiens]                                  30   3.4  
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]    30   4.4  
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    30   4.4  
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    30   4.4  
gi|22095355 basic, immunoglobulin-like variable motif containing...    30   5.8  
gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]        30   5.8  
gi|40217801 hypothetical protein LOC79864 isoform 2 [Homo sapiens]     30   5.8  
gi|196115153 CDKN1A interacting zinc finger protein 1 isoform 3 ...    29   7.5  
gi|195963418 tubulin tyrosine ligase-like family, member 6 isofo...    29   9.8  
gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide...    29   9.8  

>gi|13899275 cerebral cavernous malformation 2 isoform 2 [Homo
           sapiens]
          Length = 444

 Score =  877 bits (2266), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS 60
           MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS
Sbjct: 1   MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS 60

Query: 61  DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNV 120
           DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNV
Sbjct: 61  DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNV 120

Query: 121 KLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG 180
           KLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG
Sbjct: 121 KLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG 180

Query: 181 SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTP 240
           SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTP
Sbjct: 181 SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTP 240

Query: 241 THHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ 300
           THHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ
Sbjct: 241 THHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ 300

Query: 301 DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEK 360
           DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEK
Sbjct: 301 DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEK 360

Query: 361 DSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE 420
           DSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE
Sbjct: 361 DSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE 420

Query: 421 WDRMISDISSDIEALGCSMDQDSA 444
           WDRMISDISSDIEALGCSMDQDSA
Sbjct: 421 WDRMISDISSDIEALGCSMDQDSA 444


>gi|71067341 cerebral cavernous malformation 2 isoform 1 [Homo
           sapiens]
          Length = 465

 Score =  857 bits (2215), Expect = 0.0
 Identities = 434/435 (99%), Positives = 435/435 (100%)

Query: 10  KPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY 69
           +PGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY
Sbjct: 31  EPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKY 90

Query: 70  LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED 129
           LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED
Sbjct: 91  LGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGED 150

Query: 130 IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP 189
           IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP
Sbjct: 151 IILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGP 210

Query: 190 VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD 249
           VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD
Sbjct: 211 VEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSD 270

Query: 250 DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK 309
           DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK
Sbjct: 271 DSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTK 330

Query: 310 LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL 369
           LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL
Sbjct: 331 LSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFL 390

Query: 370 ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS 429
           ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS
Sbjct: 391 ETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDIS 450

Query: 430 SDIEALGCSMDQDSA 444
           SDIEALGCSMDQDSA
Sbjct: 451 SDIEALGCSMDQDSA 465


>gi|31542255 hypothetical protein LOC140706 [Homo sapiens]
          Length = 433

 Score =  146 bits (369), Expect = 3e-35
 Identities = 82/166 (49%), Positives = 110/166 (66%), Gaps = 6/166 (3%)

Query: 1   MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPER-VEPDRLL 59
           ME E KKGKK G VSP +R+     K+  + A      RRPLH++ L  P+  ++P  LL
Sbjct: 1   MEYEVKKGKK-GFVSPIRRLVFP--KAGRRAACRSSVSRRPLHSMPLYPPDYLIDPQILL 57

Query: 60  SDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYN 119
            DY+EKEVK+LG LT +   LNPSSR E+L  +D A++  +LP   T E D++LSLSA  
Sbjct: 58  CDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTAEQDSILSLSARC 117

Query: 120 VKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISP 165
           + L WRD E++ILR+P H+IAA SY++DDA HL+VLKT    G+ P
Sbjct: 118 LLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGL--GVDP 161



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 25/52 (48%), Positives = 35/52 (67%)

Query: 189 PVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTP 240
           P   C LVILA  ++ AAEE C L+ QVFQ++Y + +I+ +DRA +   STP
Sbjct: 297 PDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYTSTP 348


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform
           2 [Homo sapiens]
          Length = 8749

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 113 LSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPG 162
           L +S  NVKL  +D EDI  RVP+ D  A   +    AHL+  ++ Q+ G
Sbjct: 742 LEVSFMNVKLLIQDLEDIEQRVPVMD--AQYKIITKTAHLITKESPQEEG 789


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform
           1 [Homo sapiens]
          Length = 8797

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 113 LSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPG 162
           L +S  NVKL  +D EDI  RVP+ D  A   +    AHL+  ++ Q+ G
Sbjct: 735 LEVSFMNVKLLIQDLEDIEQRVPVMD--AQYKIITKTAHLITKESPQEEG 782


>gi|4557757 MutL protein homolog 1 [Homo sapiens]
          Length = 756

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 17/55 (30%), Positives = 27/55 (49%)

Query: 62  YIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLS 116
           YI +E    GQ + +PG +  S +  + H +  A R+H LP     E   +L L+
Sbjct: 690 YISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLA 744


>gi|12383066 axotrophin [Homo sapiens]
          Length = 704

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 3/67 (4%)

Query: 125 RDGEDIILRVPIHDIAAVSYV-RDDAAHLVVLKTAQDP--GISPSQSLCAESSRGLSAGS 181
           R+G D   R+P  D ++ S++ R ++  +V L+   DP    +      A SS   + GS
Sbjct: 403 REGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGS 462

Query: 182 LSESAVG 188
            S+SA G
Sbjct: 463 TSDSAQG 469


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)

Query: 56  DRLLSDYIEKEVKYLGQLTSIPGYLNPSS-RTEILHFIDNAKRAHQLPGHLTQEH---DA 111
           D  + D  +  +KY G++T IP  +  SS + ++ +F  + +      G  + +    D 
Sbjct: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189

Query: 112 VLSLSAYNVKLAWRDGEDIILRVP--IHDI 139
           VL  S+ N+K  W  GE  I++ P   HDI
Sbjct: 190 VLIGSSMNLKDYWESGEWAIIKAPGYKHDI 219


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score = 30.0 bits (66), Expect = 4.4
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 71   GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAV 112
            G L+S P  LNP+    +L  +   +   + PGHL  EH A+
Sbjct: 1275 GDLSSAPQELNPAVTAALLQLLSQPEA--EPPGHLPHEHQAL 1314


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score = 30.0 bits (66), Expect = 4.4
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 71   GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAV 112
            G L+S P  LNP+    +L  +   +   + PGHL  EH A+
Sbjct: 1284 GDLSSAPQELNPAVTAALLQLLSQPEA--EPPGHLPHEHQAL 1323


>gi|22095355 basic, immunoglobulin-like variable motif containing
           isoform a [Homo sapiens]
          Length = 503

 Score = 29.6 bits (65), Expect = 5.8
 Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 12/104 (11%)

Query: 164 SPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTE 223
           +PS+S C   S  LSAG+ S   +G   +   +I   E+ +  E L   LG++       
Sbjct: 87  NPSRSPCLPDSTSLSAGNNSSRYIGIPTSTSEIIYNEENSL--ENLSNSLGKL------- 137

Query: 224 STIDFLDRAIFDGASTPTHHLSLHSDDSSTK---VDIKETYEVE 264
                +D++ FDG +T + H S ++    +K    D K  Y+ E
Sbjct: 138 PLAWEIDKSEFDGVTTNSKHKSGNAKKQVSKRKTSDKKGRYQKE 181


>gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]
          Length = 4857

 Score = 29.6 bits (65), Expect = 5.8
 Identities = 14/47 (29%), Positives = 25/47 (53%)

Query: 276  VGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALL 322
            + G SPH       ++  +AT+ +Q+++  L+  LSS   Q F+  L
Sbjct: 2766 LSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFL 2812


>gi|40217801 hypothetical protein LOC79864 isoform 2 [Homo sapiens]
          Length = 307

 Score = 29.6 bits (65), Expect = 5.8
 Identities = 36/134 (26%), Positives = 51/134 (38%), Gaps = 11/134 (8%)

Query: 1   MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS 60
           ME  G KG++    SP     L G +             +P     LS  +  E    LS
Sbjct: 171 MELSGGKGEQKE--SPQSAASLLGSEFLSPNYEHGARRSKPFSE--LSDSDLEEKSSSLS 226

Query: 61  DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNV 120
            Y++    +      +PG   P  R    HF++  K    LP   T + D+ L L  +N 
Sbjct: 227 PYVKSSSSH--NEVFLPGSRGPRRRKSKQHFVEKNKLTLGLP---TPKTDSYLQL--HNK 279

Query: 121 KLAWRDGEDIILRV 134
           K      E +ILRV
Sbjct: 280 KRGESHPEQVILRV 293


>gi|196115153 CDKN1A interacting zinc finger protein 1 isoform 3
           [Homo sapiens]
          Length = 837

 Score = 29.3 bits (64), Expect = 7.5
 Identities = 17/35 (48%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 386 GRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE 420
           GR+ +  + TSSSTT  NR T   +D+S P EG E
Sbjct: 178 GRNPQKQARTSSSTTP-NRKTMPVEDKSDPPEGSE 211


>gi|195963418 tubulin tyrosine ligase-like family, member 6 isoform
           1 [Homo sapiens]
          Length = 891

 Score = 28.9 bits (63), Expect = 9.8
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 90  HFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILR--VPIHDIAAVSY 144
           H  + ++ AH           A L   +YNV+  WRD ED+I++  +  H I   +Y
Sbjct: 319 HSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNY 375


>gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 462

 Score = 28.9 bits (63), Expect = 9.8
 Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 13/76 (17%)

Query: 327 NGASIHEFCINLRQLYGDSRKF-----LLLGL-------RPFIPEKDSQHFENFLET-IG 373
           N  S+HEF +NL + YG    F     L++ L       +   P K S  FE  L++ + 
Sbjct: 50  NSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLR 109

Query: 374 VKDGRGIITDSFGRHR 389
            + G G ++++  R +
Sbjct: 110 YQSGGGSVSENHMRKK 125


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,366,768
Number of Sequences: 37866
Number of extensions: 698321
Number of successful extensions: 2377
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2364
Number of HSP's gapped (non-prelim): 20
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.