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Search of human proteins with 13775238
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13775238 plasmalemma vesicle associated protein [Homo
sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13775238 plasmalemma vesicle associated protein [Homo sapiens] 866 0.0
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 66 6e-11
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 56 7e-08
gi|58530840 desmoplakin isoform I [Homo sapiens] 55 1e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 55 1e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 54 2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 54 3e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 54 3e-07
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 52 1e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 52 1e-06
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 51 2e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 51 2e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 51 2e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 51 2e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 51 2e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 51 2e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 51 2e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 51 2e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 51 2e-06
gi|81295809 pericentrin [Homo sapiens] 51 2e-06
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 50 4e-06
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 50 5e-06
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 50 5e-06
gi|148746195 trichohyalin [Homo sapiens] 50 5e-06
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 50 5e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 7e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 7e-06
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 49 7e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 49 9e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 49 9e-06
>gi|13775238 plasmalemma vesicle associated protein [Homo sapiens]
Length = 442
Score = 866 bits (2237), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNL 60
MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNL
Sbjct: 1 MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNL 60
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQ 120
QATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQ
Sbjct: 61 QATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQ 120
Query: 121 GDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICT 180
GDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICT
Sbjct: 121 GDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICT 180
Query: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNL 240
KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNL
Sbjct: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNL 240
Query: 241 WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE 300
WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE
Sbjct: 241 WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE 300
Query: 301 NSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDN 360
NSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDN
Sbjct: 301 NSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDN 360
Query: 361 LAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEE 420
LAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEE
Sbjct: 361 LAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEE 420
Query: 421 FKRKILESQRPPAGIPVAPSSG 442
FKRKILESQRPPAGIPVAPSSG
Sbjct: 421 FKRKILESQRPPAGIPVAPSSG 442
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 66.2 bits (160), Expect = 6e-11
Identities = 78/358 (21%), Positives = 152/358 (42%), Gaps = 55/358 (15%)
Query: 66 RAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVI 125
+AEG+ G ++ +++ T D + Q L A L + A +Q Q +R +
Sbjct: 1919 KAEGVID---GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
Query: 126 YTNNQRYMAA--------IILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
+ + M A ++ ++ + ++ + + L ++VK LE+++
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV----- 2030
Query: 178 ICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKV------QALCLPLDKD 231
+E V + +E+ E + R Q+ Q ++QL+K+ QA+ ++D
Sbjct: 2031 -----EEQVSRFIELEQEKNTELMDLR----QQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 232 KFEMDLRNLWRD-SIIPRSLDNLGYNLYHPLGS-ELASIRRACDHMPSLMSSKVEELARS 289
F+ +++ L + ++PR + P+ + + + +H+ + K EL S
Sbjct: 2082 VFQQEIQKLEQQLKVVPR---------FQPISEHQTREVEQLANHLKE-KTDKCSELLLS 2131
Query: 290 ---LRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQL 346
L+ DI+ E L+ + E +Q L S + QKVE + + E S + QL
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
Query: 347 ALEEKAVLRKER---------DNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
E A+ RKE+ + +ELE K E +QL M+L I+ T ++ Q
Sbjct: 2192 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249
Score = 47.8 bits (112), Expect = 2e-05
Identities = 52/217 (23%), Positives = 96/217 (44%), Gaps = 14/217 (6%)
Query: 168 LEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLP 227
LE E AK +DKE + K E Q ++ L Q++QL E QK+++ +
Sbjct: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
Query: 228 LDKDKFEMDLRNLWRDSIIPRSLDNL-----GYNLYHPLGSELASIRRACDHMPSLMSSK 282
D E RNL ++ + + L ++L S P L S
Sbjct: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
Query: 283 -VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
++EL + L R+ ++ ++ KL+ S + +Q++EK+ Q LQ E
Sbjct: 3344 LLKELQKQLEEKHSRIVELLNETEKYKLD-------SLQTRQQMEKDRQVHRKTLQTEQE 3396
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
T+ ++ L+ + ++L ++LEEK+++ +L +E
Sbjct: 3397 ANTE-GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3432
Score = 46.6 bits (109), Expect = 5e-05
Identities = 70/330 (21%), Positives = 137/330 (41%), Gaps = 25/330 (7%)
Query: 83 NLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQ 142
N+ KE NF + R +++I + + + + + ++L+E
Sbjct: 2414 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE-- 2471
Query: 143 CRDQFKDMNKSCDALLFMLNQKVKTLEVE---IAKEKTICTKDKESVLLNKRVAEEQLVE 199
D K + F N K + +E + E T+ KD E K++ + Q
Sbjct: 2472 --DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2529
Query: 200 CVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS------LDNL 253
+T LQ + L K +KV A + + + + +D+ S + NL
Sbjct: 2530 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
Query: 254 GYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERV-ARENSDLQRQK--LE 310
LGS+++++ S + S+V E+ SL + E+V E + L+++K LE
Sbjct: 2590 NQLREDELGSDISALTLRI----SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
Query: 311 AQQGLRASQEAKQKVEKEAQAREAKL-----QAECSRQTQLALEEKAVLRKERDNLAKEL 365
Q+ L +++ +++ EK+ ++ ++ + S + E LR E EL
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
Query: 366 EEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
K +AE+L+ EL ++ + + + K SQ
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2735
Score = 36.6 bits (83), Expect = 0.047
Identities = 87/445 (19%), Positives = 155/445 (34%), Gaps = 119/445 (26%)
Query: 47 MVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNAR 106
+ YG + +A ++ +G+ +QL T L R KD M+ +L
Sbjct: 183 VTYGTEGLQQLQEFEAAIKQRDGIITQL----------TANLQQARREKDETMREFLELT 232
Query: 107 RDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQ--------------CRDQFKDMNK 152
++ F+Q Q + + AA +L KQ + ++ +
Sbjct: 233 EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
Query: 153 SCDALLFMLNQKVKTLEVEIAKEKTICTKD----KESVL--LNKRVAEEQL--------- 197
+ L +K+K E+E K+ K+ KE+++ LN ++ EE+
Sbjct: 293 DFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL 352
Query: 198 -------------------------VECVKTRELQHQERQLAKEQLQKVQALCLPLDKD- 231
+E +++ + Q + K+ + V+ L KD
Sbjct: 353 TTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS 412
Query: 232 KFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC--DHMPS------------ 277
+FE D+ R L+ L L G ++ +++ HM
Sbjct: 413 QFETDIVQRMEQET-QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEM 471
Query: 278 ------------------LMSSKVEEL----------ARSLRADIERVARENSDLQRQKL 309
LM+ + EL L+ ++ + E LQRQ
Sbjct: 472 ENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
Query: 310 EAQQGLRASQEAKQKVEKEAQAREAKL-QAECSRQTQLALEEKAVLRKERDNLAKELEEK 368
+ + L S+E Q+ + +E+KL +A S T L+ + V E KEL E
Sbjct: 532 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES---RKEL-EL 587
Query: 369 KREAE------QLRMELAIRNSALD 387
K EAE +L M +N+ LD
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLD 612
Score = 35.8 bits (81), Expect = 0.080
Identities = 65/269 (24%), Positives = 116/269 (43%), Gaps = 51/269 (18%)
Query: 155 DALLFMLNQKVKTLEVE----IAKEKTICT-----KDKESVLLNKRVAEE--QLVECVKT 203
D L ++QK++T++ E I K+ + KD + L+N + E Q+ E K
Sbjct: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE 727
Query: 204 RELQHQERQLAKEQLQKVQALCLPLD------KDKFEMDLRNLW-----RDSIIP---RS 249
E+ QE + Q+VQ L L + K+K E DL+ + +SI+ ++
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK-ENDLQEKFAQLEAENSILKDEKKT 786
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+++ ++ P+ E + + L S K + +IE + EN DL++Q +
Sbjct: 787 LEDM-LKIHTPVSQE--------ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837
Query: 310 EAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLA----KEL 365
+ + + + EK + +LQ EE A L K +D+L K+
Sbjct: 838 QLNEEIEKQRNTFSFAEKNFEVNYQELQ-----------EEYACLLKVKDDLEDSKNKQE 886
Query: 366 EEKKREAEQLRMELAIRNSALDTCIKTKS 394
E K + + L EL ++ T +K KS
Sbjct: 887 LEYKSKLKALNEELHLQR-INPTTVKMKS 914
Score = 32.7 bits (73), Expect = 0.68
Identities = 28/120 (23%), Positives = 63/120 (52%), Gaps = 12/120 (10%)
Query: 274 HMPSLMSSKVEELARSLR---ADIERVARENSDLQR----QKLEAQQGLRASQEAKQKVE 326
++ S + + VE+L ++ + +E ++L R QK EA + L+ +E ++++
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLH 1904
Query: 327 KEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
+E++ARE +L E S+ + ++ A E+ ++++EK ++L EL ++ L
Sbjct: 1905 EESRARE-QLAVELSK-AEGVIDGYA---DEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
Score = 29.3 bits (64), Expect = 7.5
Identities = 24/106 (22%), Positives = 48/106 (45%), Gaps = 11/106 (10%)
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLA 347
RSL ++I+ + + + + Q+ + SQE + ++ Q++ ++Q E S A
Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
Query: 348 LEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTK 393
E L ++L +K +L+ ELA L+T +K +
Sbjct: 3148 TE-----------LQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 55.8 bits (133), Expect = 7e-08
Identities = 93/376 (24%), Positives = 147/376 (39%), Gaps = 72/376 (19%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E QATE + + L ++ L S + LTKE K A+ + A DL
Sbjct: 1014 EKEKQATENKVKNLTEEMAALDESVARLTKE-------KKALQEAHQQALGDL------- 1059
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCR-DQFKDMNKSCDALLFMLNQKVKTLEVEIAK- 174
Q + DRV + + + +C +Q K + + L +K + +A
Sbjct: 1060 -QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADA 1118
Query: 175 -------EKTICTKDKESVLLNKRVAEEQLVEC---VKTRELQHQERQLAKEQLQKVQAL 224
E+ + KD E L+ RV +EQL+ K +ELQ + +L +E+L+ +A
Sbjct: 1119 AQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEEL-EEELEAERAA 1177
Query: 225 CLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLG-------------SELASIRRA 271
++K + E R L+ L L G +EL +RR
Sbjct: 1178 RARVEKQRAE-----------AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE 1226
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQ--RQKLEAQQG--------LRASQE- 320
+ + V L R + + LQ RQKLE ++ L A+ E
Sbjct: 1227 LEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVET 1286
Query: 321 ---AKQKVEK-----EAQAREAKLQA-ECSRQTQLALEEKAVLRKERDNLAKELEEKKRE 371
AK EK E Q EAK++ E RQ A ++ L+ E L++ LEEK+
Sbjct: 1287 LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECL 1346
Query: 372 AEQLRMELAIRNSALD 387
QL A+ +L+
Sbjct: 1347 ISQLSRGKALAAQSLE 1362
Score = 34.3 bits (77), Expect = 0.23
Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 52/255 (20%)
Query: 161 LNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR-ELQHQERQLAKEQLQ 219
L +++ +V+ ++ + KD+E N R ++ VE ++ + + + R A +
Sbjct: 1608 LRIQLELSQVKAEVDRKLAEKDEECA--NLRRNHQRAVESLQASLDAETRARNEALRLKK 1665
Query: 220 KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNL----------GYNLYHPLGSELASIR 269
K++ D + E+ L + R + ++ L G + L +EL
Sbjct: 1666 KMEG-----DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQA 1720
Query: 270 RACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRA--SQEA---KQK 324
+A + SL+++++EEL RA +E+ R +++ LEA + L SQ QK
Sbjct: 1721 QALERRASLLAAELEEL----RAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQK 1776
Query: 325 VEKEAQAREAKLQAECSRQTQLALEEKAV------------LRKERDNLA---------- 362
+ EA + + E + Q + EEKA L+KE+D A
Sbjct: 1777 KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLE 1836
Query: 363 ---KELEEKKREAEQ 374
+EL+ + EAEQ
Sbjct: 1837 QTVRELQARLEEAEQ 1851
Score = 33.9 bits (76), Expect = 0.30
Identities = 88/404 (21%), Positives = 157/404 (38%), Gaps = 87/404 (21%)
Query: 57 ESNLQATERRAEGLYSQLLG---------LTASQSNLTKELNFTTRAKDAIMQMWLNARR 107
+S L R E QLLG L A L +EL A+ + + A R
Sbjct: 1133 DSELSQLSLRVED--EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAAR 1190
Query: 108 DLDRINASFRQCQGD-------------------RVIYTNNQRYMAAIILSEKQCRDQFK 148
+L+ ++ + G R + R+ A + ++ +
Sbjct: 1191 ELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAA 1250
Query: 149 DMNKSCDALLFM---LNQKVKTLEVEI---AKEKTICTKDKESVLLNKRVAEEQLVEC-V 201
++ + D+L + L ++ L +E+ A T+ K S R E+QL E +
Sbjct: 1251 ELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKI 1310
Query: 202 KTRELQHQ--ERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRD-SIIPRSLDNLGYNLY 258
K ELQ Q + + +LQ L ++K E + L R ++ +SL+ L L
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEK-ECLISQLSRGKALAAQSLEELRRQLE 1369
Query: 259 HP------LGSELASIRRACDHMPSLMSSKVE---ELARSLRADIERVARENSDLQ---- 305
L + ++R CD + + E EL R L VA+ S +
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 306 ---------RQKL-----EAQQGLRAS-------QEAKQKVEKEAQAREAKLQAECS--- 341
++KL EA++G+ A+ ++AK +++ E++ +L+ S
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 342 ------RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
R + ALEE+ R++ + + +ELE +RE+ L EL
Sbjct: 1490 ALDKKQRHLERALEER---RRQEEEMQRELEAAQRESRGLGTEL 1530
Score = 33.1 bits (74), Expect = 0.52
Identities = 52/212 (24%), Positives = 88/212 (41%), Gaps = 38/212 (17%)
Query: 195 EQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRN------LWRDSIIPR 248
E+L E K L+ QE A+E ++ A C L+K K + + L R +
Sbjct: 1433 EELEEAKKKLALRLQE---AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 249 SLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADI-------------- 294
+LD +L L RR + M + + E +R L ++
Sbjct: 1490 ALDKKQRHLERALEER----RRQEEEMQRELEAAQRE-SRGLGTELFRLRHGHEEALEAL 1544
Query: 295 ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQARE---AKLQAECSR-QTQLALEE 350
E + REN +LQ + + + S ++ Q++EK +A E +++QA + L LEE
Sbjct: 1545 ETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEE 1604
Query: 351 KAVLR------KERDNLAKELEEKKREAEQLR 376
LR + + + ++L EK E LR
Sbjct: 1605 TKTLRIQLELSQVKAEVDRKLAEKDEECANLR 1636
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/304 (22%), Positives = 138/304 (45%), Gaps = 43/304 (14%)
Query: 87 ELNFT-TRAKDAIMQMW---LNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQ 142
E+N T T K+ MQ N R LDR++ R + D ++ N+ A +++
Sbjct: 1213 EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLK-DEIVRLNDSILQAT---EQRR 1268
Query: 143 CRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVK 202
++ K+C + + QK + LE+E+ K + + E +K + L E K
Sbjct: 1269 RAEENALQQKACGSEIM---QKKQHLEIEL---KQVMQQRSEDNARHK----QSLEEAAK 1318
Query: 203 TRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLG 262
T + +++E + K + Q+ + + ++ RN + + II +L +
Sbjct: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKV--RNNYDEEII---------SLKNQFE 1367
Query: 263 SELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAK 322
+E+ +I + H ++ + EE RA I+ + REN L + + L + E
Sbjct: 1368 TEI-NITKTTIHQ---LTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
Query: 323 QKVEKEAQAREA----------KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREA 372
++VE++ Q ++A +L+ E + TQ+ EE ++ D+ AK +++K +E
Sbjct: 1424 RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEI 1483
Query: 373 EQLR 376
E+L+
Sbjct: 1484 ERLK 1487
Score = 53.1 bits (126), Expect = 5e-07
Identities = 61/299 (20%), Positives = 133/299 (44%), Gaps = 44/299 (14%)
Query: 113 NASFRQCQGDRVIYTNNQRYMA------AIILSEKQCRDQFKDMNKS-------CDALLF 159
+A+ C ++ + N Q+Y A A + S ++ + Q + KS C +
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
Query: 160 MLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQL- 218
LN+K+ L EI EK ++ E++ + + + RQ KE L
Sbjct: 1106 ELNEKITRLTYEIEDEKR-----------RRKSVEDRFDQQKNDYDQLQKARQCEKENLG 1154
Query: 219 -QKVQALCLPLDKDKFEMDLRNLWRDS-IIPRSLDNLGYNLYHPLGSELASIRRACDHMP 276
QK+++ +K+ LR L ++ R +N + + E++++R +
Sbjct: 1155 WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 277 SLMSSKVEELA-------RSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEA 329
++ + ++E++ ++LR ++R++REN DL+ + + + + E +++ E+ A
Sbjct: 1215 NITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
Query: 330 QAREA----------KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
++A L+ E + Q E+ A ++ + AK +++K +E E+L+ E
Sbjct: 1275 LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE 1333
Score = 43.1 bits (100), Expect = 5e-04
Identities = 95/434 (21%), Positives = 167/434 (38%), Gaps = 80/434 (18%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWL-NAR--------- 106
+S LQATE+R + L + K+ + K + Q NAR
Sbjct: 1258 DSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA 1317
Query: 107 -------RDLDRINASFRQCQGDRVIYTNN-----QRYMAAIILSEKQCRDQFK------ 148
++++R+ A F++ R Y N Y II + Q +
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377
Query: 149 ---DMNKSCD-----ALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVEC 200
M K D A + L ++ ++L EI + K T+ E++ +RV E+ +
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL---RRVEEDIQQQK 1434
Query: 201 VKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD-----LRNLWRDSIIPRSLDNLGY 255
E+ +++QL E Q Q + K +D +++ ++ + L +
Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
Query: 256 NLYHPLGSELASIRRACDHMPSLMSSKVE----------ELARSLRADIERVARENSDLQ 305
N L E A ++R + SS E EL R LR D ERV++E +
Sbjct: 1495 NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR-LRIDYERVSQERTVKD 1553
Query: 306 RQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERD------ 359
+ Q L+ Q KQKVE+E + + ++ +L E + + R ++
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613
Query: 360 NLAKELEE----KKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDP 415
NL ++LE+ KKR + LR + LD ++ K + + R V
Sbjct: 1614 NLTQQLEQASIVKKRSEDDLRQQ----RDVLDGHLREKQRTQEELRRLSSEV-------- 1661
Query: 416 ASLEEFKRKILESQ 429
E +R++L+ Q
Sbjct: 1662 ---EALRRQLLQEQ 1672
Score = 36.2 bits (82), Expect = 0.061
Identities = 72/325 (22%), Positives = 139/325 (42%), Gaps = 47/325 (14%)
Query: 72 SQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQR 131
+ L L + + +ELN R +L+ + S ++ Q ++ Q
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-QAIKITNLTQQL 1619
Query: 132 YMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKR 191
A+I+ +K+ D D+ + D L L +K +T E + E L ++
Sbjct: 1620 EQASIV--KKRSED---DLRQQRDVLDGHLREKQRTQE-------ELRRLSSEVEALRRQ 1667
Query: 192 VAEEQLVECVKTRELQHQERQLAKE-----------QLQKVQALCLPLDKDKF--EMDLR 238
+ +EQ E VK L+++ Q A E +++++Q+L L K+ E +LR
Sbjct: 1668 LLQEQ--ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELR 1725
Query: 239 NLWRDSIIPRSLDNLGYNLYHPLGSELASIR--RACDHMPSLMSSKVEELARSLRADIER 296
NL + D+L + A+I R+ + + + +++ L L+ + E
Sbjct: 1726 NLRLE------YDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQREREN 1779
Query: 297 VARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRK 356
+ +E Q+Q LEA + QE+K + + Q RE+ L + ++ ++KA L++
Sbjct: 1780 LRQEIEKFQKQALEASNRI---QESKNQCTQVVQERESLLV-----KIKVLEQDKARLQR 1831
Query: 357 ERDNLAK---ELEEKKREAEQLRME 378
D L + LE + R ++L E
Sbjct: 1832 LEDELNRAKSTLEAETRVKQRLECE 1856
Score = 32.3 bits (72), Expect = 0.88
Identities = 91/416 (21%), Positives = 154/416 (37%), Gaps = 69/416 (16%)
Query: 53 HVSTESNLQATERRAEGLYSQLLGLTASQS---NLTKELNFTTRAKDAIMQMWLNARR-- 107
H+ E +A E ++ L + + QS NLTKE + + + RR
Sbjct: 1679 HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGR 1738
Query: 108 ---DLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQK 164
D D+ NA+ + + I N + +I ++ R+ + + + +
Sbjct: 1739 SEADSDK-NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNR 1797
Query: 165 VKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR-ELQHQERQLAKEQLQKVQA 223
++ E + T +++ES+L+ +V E+ + EL + L E K +
Sbjct: 1798 IQ----ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853
Query: 224 LCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKV 283
C +K + + DL N W+ Y+ ++ S R K
Sbjct: 1854 EC---EKQQIQNDL-NQWKTQ----------YSRKEEAIRKIESERE-----------KS 1888
Query: 284 EELARSLRADIERVARENSDLQ---RQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAE- 339
E SLR++IER+ E ++ R+KLE R +Q + Q KL+
Sbjct: 1889 EREKNSLRSEIERLQAEIKRIEERCRRKLE--DSTRETQSQLETERSRYQREIDKLRQRP 1946
Query: 340 --CSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTK---- 393
R+TQ E + L + KK A QL I + LD +K K
Sbjct: 1947 YGSHRETQTECEWTV----DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVE 2002
Query: 394 --SQPMMPVSRPMGPV--PNPQPIDPASLEEFKRK----------ILESQRPPAGI 435
+ + P R G + + P + SL E KRK +LE+Q GI
Sbjct: 2003 EVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058
Score = 29.6 bits (65), Expect = 5.7
Identities = 46/229 (20%), Positives = 91/229 (39%), Gaps = 35/229 (15%)
Query: 164 KVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQA 223
K+K ++E+ +E+ +D S NK + + LQK QA
Sbjct: 1028 KLKNTKIEVLEEELRLARDANSENCNK--------------------NKFLDQNLQKYQA 1067
Query: 224 LCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKV 283
C +F+ L +L + R + G + L I+ + + L + ++
Sbjct: 1068 EC-----SQFKAKLASL---EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL-TYEI 1118
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
E+ R ++ +R ++ +D +L+ + QK+E E +E + + E +
Sbjct: 1119 EDEKRRRKSVEDRFDQQKNDY--DQLQKARQCEKENLGWQKLESEKAIKEKEYEIE---R 1173
Query: 344 TQLALEEKAVLRKERDN-LAKELEEKKREAEQLRMELAIRNSALDTCIK 391
++ L+E+ ++E +N LAK E LR + + T IK
Sbjct: 1174 LRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK 1222
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 55.1 bits (131), Expect = 1e-07
Identities = 78/358 (21%), Positives = 149/358 (41%), Gaps = 63/358 (17%)
Query: 66 RAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVI 125
+AEG+ G ++ +++ T D + Q L A L + A +Q Q +R +
Sbjct: 1919 KAEGVID---GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
Query: 126 YTNNQRYMAA--------IILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
+ + M A ++ ++ + ++ + + L ++VK LE+++
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV----- 2030
Query: 178 ICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKV------QALCLPLDKD 231
+E V + +E+ E + R Q+ Q ++QL+K+ QA+ ++D
Sbjct: 2031 -----EEQVSRFIELEQEKNTELMDLR----QQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 232 KFEMDLRNLWRD-SIIPRSLDNLGYNLYHPLGS-ELASIRRACDHMPSLMSSKVEELARS 289
F+ +++ L + ++PR + P+ + + + +H+ + K EL S
Sbjct: 2082 VFQQEIQKLEQQLKVVPR---------FQPISEHQTREVEQLANHLKE-KTDKCSELLLS 2131
Query: 290 ---LRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQL 346
L+ DI+ E L+ + E +Q L K A EAK E S + QL
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR------KHFGAVEAK--PELSLEVQL 2183
Query: 347 ALEEKAVLRKERD---------NLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
E A+ RKE++ +ELE K E +QL M+L I+ T ++ Q
Sbjct: 2184 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2241
Score = 47.8 bits (112), Expect = 2e-05
Identities = 52/217 (23%), Positives = 96/217 (44%), Gaps = 14/217 (6%)
Query: 168 LEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLP 227
LE E AK +DKE + K E Q ++ L Q++QL E QK+++ +
Sbjct: 3216 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275
Query: 228 LDKDKFEMDLRNLWRDSIIPRSLDNL-----GYNLYHPLGSELASIRRACDHMPSLMSSK 282
D E RNL ++ + + L ++L S P L S
Sbjct: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335
Query: 283 -VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
++EL + L R+ ++ ++ KL+ S + +Q++EK+ Q LQ E
Sbjct: 3336 LLKELQKQLEEKHSRIVELLNETEKYKLD-------SLQTRQQMEKDRQVHRKTLQTEQE 3388
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
T+ ++ L+ + ++L ++LEEK+++ +L +E
Sbjct: 3389 ANTE-GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3424
Score = 46.6 bits (109), Expect = 5e-05
Identities = 70/330 (21%), Positives = 137/330 (41%), Gaps = 25/330 (7%)
Query: 83 NLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQ 142
N+ KE NF + R +++I + + + + + ++L+E
Sbjct: 2406 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE-- 2463
Query: 143 CRDQFKDMNKSCDALLFMLNQKVKTLEVE---IAKEKTICTKDKESVLLNKRVAEEQLVE 199
D K + F N K + +E + E T+ KD E K++ + Q
Sbjct: 2464 --DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2521
Query: 200 CVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS------LDNL 253
+T LQ + L K +KV A + + + + +D+ S + NL
Sbjct: 2522 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2581
Query: 254 GYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERV-ARENSDLQRQK--LE 310
LGS+++++ S + S+V E+ SL + E+V E + L+++K LE
Sbjct: 2582 NQLREDELGSDISALTLRI----SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2637
Query: 311 AQQGLRASQEAKQKVEKEAQAREAKL-----QAECSRQTQLALEEKAVLRKERDNLAKEL 365
Q+ L +++ +++ EK+ ++ ++ + S + E LR E EL
Sbjct: 2638 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2697
Query: 366 EEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
K +AE+L+ EL ++ + + + K SQ
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727
Score = 36.6 bits (83), Expect = 0.047
Identities = 87/445 (19%), Positives = 155/445 (34%), Gaps = 119/445 (26%)
Query: 47 MVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNAR 106
+ YG + +A ++ +G+ +QL T L R KD M+ +L
Sbjct: 183 VTYGTEGLQQLQEFEAAIKQRDGIITQL----------TANLQQARREKDETMREFLELT 232
Query: 107 RDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQ--------------CRDQFKDMNK 152
++ F+Q Q + + AA +L KQ + ++ +
Sbjct: 233 EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
Query: 153 SCDALLFMLNQKVKTLEVEIAKEKTICTKD----KESVL--LNKRVAEEQL--------- 197
+ L +K+K E+E K+ K+ KE+++ LN ++ EE+
Sbjct: 293 DFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL 352
Query: 198 -------------------------VECVKTRELQHQERQLAKEQLQKVQALCLPLDKD- 231
+E +++ + Q + K+ + V+ L KD
Sbjct: 353 TTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS 412
Query: 232 KFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC--DHMPS------------ 277
+FE D+ R L+ L L G ++ +++ HM
Sbjct: 413 QFETDIVQRMEQET-QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEM 471
Query: 278 ------------------LMSSKVEEL----------ARSLRADIERVARENSDLQRQKL 309
LM+ + EL L+ ++ + E LQRQ
Sbjct: 472 ENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
Query: 310 EAQQGLRASQEAKQKVEKEAQAREAKL-QAECSRQTQLALEEKAVLRKERDNLAKELEEK 368
+ + L S+E Q+ + +E+KL +A S T L+ + V E KEL E
Sbjct: 532 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES---RKEL-EL 587
Query: 369 KREAE------QLRMELAIRNSALD 387
K EAE +L M +N+ LD
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLD 612
Score = 35.8 bits (81), Expect = 0.080
Identities = 65/269 (24%), Positives = 116/269 (43%), Gaps = 51/269 (18%)
Query: 155 DALLFMLNQKVKTLEVE----IAKEKTICT-----KDKESVLLNKRVAEE--QLVECVKT 203
D L ++QK++T++ E I K+ + KD + L+N + E Q+ E K
Sbjct: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE 727
Query: 204 RELQHQERQLAKEQLQKVQALCLPLD------KDKFEMDLRNLW-----RDSIIP---RS 249
E+ QE + Q+VQ L L + K+K E DL+ + +SI+ ++
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK-ENDLQEKFAQLEAENSILKDEKKT 786
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+++ ++ P+ E + + L S K + +IE + EN DL++Q +
Sbjct: 787 LEDM-LKIHTPVSQE--------ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837
Query: 310 EAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLA----KEL 365
+ + + + EK + +LQ EE A L K +D+L K+
Sbjct: 838 QLNEEIEKQRNTFSFAEKNFEVNYQELQ-----------EEYACLLKVKDDLEDSKNKQE 886
Query: 366 EEKKREAEQLRMELAIRNSALDTCIKTKS 394
E K + + L EL ++ T +K KS
Sbjct: 887 LEYKSKLKALNEELHLQR-INPTTVKMKS 914
Score = 32.7 bits (73), Expect = 0.68
Identities = 28/120 (23%), Positives = 63/120 (52%), Gaps = 12/120 (10%)
Query: 274 HMPSLMSSKVEELARSLR---ADIERVARENSDLQR----QKLEAQQGLRASQEAKQKVE 326
++ S + + VE+L ++ + +E ++L R QK EA + L+ +E ++++
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLH 1904
Query: 327 KEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
+E++ARE +L E S+ + ++ A E+ ++++EK ++L EL ++ L
Sbjct: 1905 EESRARE-QLAVELSK-AEGVIDGYA---DEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
Score = 29.3 bits (64), Expect = 7.5
Identities = 24/106 (22%), Positives = 48/106 (45%), Gaps = 11/106 (10%)
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLA 347
RSL ++I+ + + + + Q+ + SQE + ++ Q++ ++Q E S A
Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3139
Query: 348 LEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTK 393
E L ++L +K +L+ ELA L+T +K +
Sbjct: 3140 TE-----------LQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3174
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 2e-07
Identities = 73/321 (22%), Positives = 134/321 (41%), Gaps = 40/321 (12%)
Query: 68 EGLYSQLL----GLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDR 123
E L SQL LT L +++ T+AK+A+ ++R D D + + + Q +
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 124 VIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDK 183
QR ++ Q R +++ DA+ +T E+E AK+K +
Sbjct: 1359 A---ELQRALSKANSEVAQWRTKYET-----DAIQ-------RTEELEEAKKKL--AQRL 1401
Query: 184 ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD-LRNLWR 242
+ N A + KT++ E + L++ C LDK + D + W+
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 243 DSIIPRSLD-NLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVAREN 301
+ + L +EL +R A + + V++L +LR + + + E
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEV-------VDQL-ETLRRENKNLQEEI 1513
Query: 302 SDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKE---- 357
SDL Q E + L+ +++ K+ VE+E + L+ + L EE +LR +
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE---EVEGSLEHEESKILRVQLELS 1570
Query: 358 --RDNLAKELEEKKREAEQLR 376
+ L +++ EK E EQL+
Sbjct: 1571 QVKSELDRKVIEKDEEIEQLK 1591
Score = 49.7 bits (117), Expect = 5e-06
Identities = 85/379 (22%), Positives = 158/379 (41%), Gaps = 67/379 (17%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNA-------RR 107
S NL E R EGL + L A LT+ L ++ N +R
Sbjct: 897 SETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 108 DLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKT 167
D+D + + + + ++ N + K++++ AL +++
Sbjct: 957 DIDDLELTLTKVEKEKHATEN-----------------KVKNLSEEMTALEENISK---- 995
Query: 168 LEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLP 227
+ KEK + + L + +V E+++ +K Q+ + L++ + L
Sbjct: 996 ----LTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD 1051
Query: 228 LD--KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGS---ELASIRRACD--HMPSL-- 278
L+ K K E DL+ + ++SI+ L+N + L EL+ ++ D + SL
Sbjct: 1052 LERAKRKLEGDLK-MSQESIM--DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQF 1108
Query: 279 ------MSSKVEELAR------SLRADIER----VARENSDLQRQKLEAQQGLRASQEAK 322
+ +++EEL +LRA IE+ +ARE ++ + EA A E
Sbjct: 1109 QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
Query: 323 QKVEKEAQA-----REAKLQAECSRQT--QLALEEKAVLRKERDNLAKELEEKKREAEQL 375
+K E E Q EA LQ E + T + + A L ++ DNL + ++ ++E +L
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEL 1228
Query: 376 RMELAIRNSALDTCIKTKS 394
+ME+ S ++ K+KS
Sbjct: 1229 KMEIDDMASNIEALSKSKS 1247
Score = 48.9 bits (115), Expect = 9e-06
Identities = 80/391 (20%), Positives = 156/391 (39%), Gaps = 48/391 (12%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIM---QMWLNARRDLDRIN 113
E ATE + + L ++ L + S LTKE A + Q+ + L +IN
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKIN 1028
Query: 114 ASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIA 173
A Q D + + EK+ R + + + L M + + LE +
Sbjct: 1029 AKLEQQTDD----------LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 174 K-EKTICTKDKESVLLNKRVAEEQLVECV---KTRELQHQERQLAKEQLQKVQALCLPLD 229
+ E+ + K+ E L ++ +EQ+ K +ELQ + +L +E+++ L ++
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEEL-EEEIEAEHTLRAKIE 1137
Query: 230 KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARS 289
K + S + R L+ + L G+ A I M+ K E +
Sbjct: 1138 KQR-----------SDLARELEEISERLEEASGATSAQIE---------MNKKREAEFQK 1177
Query: 290 LRADIERVAREN----SDLQRQKLEAQQGLRAS----QEAKQKVEKEAQAREAKLQAECS 341
+R D+E ++ + L++++ ++ L Q KQK+EKE + ++ S
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 342 RQTQLALEEKAVLRKER--DNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMP 399
L+ + + R R ++ E++ K + QL +L ++ + L T S +
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 400 VSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
+ + + LEE KR++ E +
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETK 1328
Score = 31.6 bits (70), Expect = 1.5
Identities = 51/238 (21%), Positives = 93/238 (39%), Gaps = 46/238 (19%)
Query: 160 MLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQ 219
++N K K LE +IA+ C + E+ + R AEE+ + + + + E+L+
Sbjct: 1727 LINTK-KKLEADIAQ----CQAEVENSIQESRNAEEKAKKAIT-------DAAMMAEELK 1774
Query: 220 KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLM 279
K Q L++ K ++L+ +L H L + +
Sbjct: 1775 KEQDTSAHLERMK---------------KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1819
Query: 280 SSKVEELARSLRADIERVA----------RENSDLQRQKLEAQQGLRASQEAKQKVEKEA 329
++V EL L + +R A R+ ++ Q E + + Q+ K++ +
Sbjct: 1820 ENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKV 1879
Query: 330 -----QAREAKLQAECS----RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
QA EA+ QA R+ Q LEE A ++ +L K R+ +ME
Sbjct: 1880 KSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 30.8 bits (68), Expect = 2.6
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 14/153 (9%)
Query: 284 EELARS------LRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQ 337
EELARS L + + +E +DLQ Q + L ++E + + K EAK++
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVK 924
Query: 338 AECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA---IRNSALDTCIKTKS 394
E + + + E + L ++ NL + KR+ + L + L A + +K S
Sbjct: 925 -ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 395 QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILE 427
+ M + + + + SL+E ++ L+
Sbjct: 984 EEMTALEENISKLTK----EKKSLQEAHQQTLD 1012
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/311 (22%), Positives = 134/311 (43%), Gaps = 34/311 (10%)
Query: 85 TKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQ-RYMAAIILSEKQC 143
TK L+ ++A+ Q + +L+R+N FR D + ++ + + + S++
Sbjct: 1476 TKALSLARALEEAMEQ-----KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 144 RDQFKDMNKSCDAL---LFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVEC 200
Q ++M + L L LEV + K +D + ++QLV
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV-- 1588
Query: 201 VKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHP 260
R+++ E +L E+ Q+ A+ + K EMDL++L +D+ N
Sbjct: 1589 ---RQVREMEAELEDERKQRSMAVAA---RKKLEMDLKDL------EAHIDSANKNR--- 1633
Query: 261 LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLR 316
+ +R+ M M + R+ R +I A+EN ++ + ++ Q+ L
Sbjct: 1634 -DEAIKQLRKLQAQMKDCMRELDD--TRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 317 ASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
A++ AK++ ++E ++ A S + LALEEK L L +ELEE++ E +
Sbjct: 1691 AAERAKRQAQQERDELADEI-ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 377 MELAIRNSALD 387
L N +D
Sbjct: 1750 DRLKKANLQID 1760
Score = 52.8 bits (125), Expect = 6e-07
Identities = 51/242 (21%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 161 LNQKVKTLEVEIAKEK-TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQ 219
L Q++ L V++ ++ + C +K+ ++ +AEE+ + E E + A+E+
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE-AREKET 1476
Query: 220 KVQALCLPLDK---DKFEMD-LRNLWRDSI--IPRSLDNLGYNLYHPLGSELASIRRACD 273
K +L L++ K E++ L +R + + S D++G +++ EL +RA +
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH-----ELEKSKRALE 1531
Query: 274 HMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRA----SQEAKQKVEKEA 329
M +++EEL L+A + R +LQ K + ++ L+ S+E K+++ ++
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 330 QAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTC 389
+ EA+L+ E +Q +A+ + L + +L ++ + ++ +L + + C
Sbjct: 1592 REMEAELEDE-RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 390 IK 391
++
Sbjct: 1651 MR 1652
Score = 47.4 bits (111), Expect = 3e-05
Identities = 55/249 (22%), Positives = 116/249 (46%), Gaps = 23/249 (9%)
Query: 140 EKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT-ICTKDKESVLLNKRVAEEQLV 198
E++ R + + + + L+ ++ L+ +IA+ K + K++E RV EE
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 199 ECVKTRELQHQERQLAK--EQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYN 256
+ + ++++ E Q+++ E L+ +A ++K E R+L + L+ L
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERA-----SRNKAEKQKRDLGEE------LEALKTE 1147
Query: 257 LYHPLGSELAS--IRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG 314
L L S A +R + +++ +EE A++ A I+ + +++S + E
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ--- 1204
Query: 315 LRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEE---KKRE 371
L ++ K +EK Q E + + E + + ++ L+ K +R + +L+E K E
Sbjct: 1205 LEQTKRVKANLEKAKQTLENE-RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 372 AEQLRMELA 380
E++R ELA
Sbjct: 1264 GERVRTELA 1272
Score = 41.6 bits (96), Expect = 0.001
Identities = 68/247 (27%), Positives = 105/247 (42%), Gaps = 63/247 (25%)
Query: 161 LNQKVKTLEVEIAKEKTICTKDKE-----SVLLNKRVA------------EEQLVECVKT 203
L ++ K LE IA+ T T+++E + L NK A E+Q E KT
Sbjct: 990 LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT 1049
Query: 204 R---------------ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPR 248
R ELQ Q +L + +K + L L + + E +N+ I R
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI--R 1107
Query: 249 SLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQK 308
L++ L L SE AS +K E+ R L ++E + E D
Sbjct: 1108 ELESQISELQEDLESERAS------------RNKAEKQKRDLGEELEALKTELEDTL-DS 1154
Query: 309 LEAQQGLRASQEA-----KQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAK 363
AQQ LR+ +E K+ +E+EA+ EA++Q + +Q A+EE LA+
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ-AVEE----------LAE 1203
Query: 364 ELEEKKR 370
+LE+ KR
Sbjct: 1204 QLEQTKR 1210
Score = 39.3 bits (90), Expect = 0.007
Identities = 53/275 (19%), Positives = 123/275 (44%), Gaps = 37/275 (13%)
Query: 127 TNNQRYMAAIILSEKQCRDQFKDMNKSC---DALLFMLNQKVKTLEVEIAKEKTICTKDK 183
T + + ++ + Q ++Q + + C + L L K + LE EI + +++
Sbjct: 869 TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE-EICHDLEARVEEE 927
Query: 184 ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRD 243
E + + ++++ + ++ E Q +E + A+++LQ L+K E L+ L +
Sbjct: 928 EERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ--------LEKVTTEAKLKKLEEE 979
Query: 244 SIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIER---VARE 300
II + +LA ++ L+ ++ E +L + E+ +A+
Sbjct: 980 QIILEDQN-----------CKLAKEKK-------LLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 301 NSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDN 360
+ + + ++ LR ++ +Q++EK + KL+ + + + E +A + + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRR----KLEGDSTDLSDQIAELQAQIAELKMQ 1077
Query: 361 LAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LAK+ EE + ++ E A +N AL + +SQ
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Score = 37.0 bits (84), Expect = 0.036
Identities = 54/289 (18%), Positives = 124/289 (42%), Gaps = 25/289 (8%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E+++ + + + QL L A + +EL+ T +++ I+ + L + A
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAK-E 175
Q Q + +R +Q RD+ D + + ++ + LE IA+ E
Sbjct: 1683 IQLQEELAAAERAKR-------QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735
Query: 176 KTICTKDKESVLLNKRVAEEQL-VECVKTR---ELQH-QERQLAKEQLQKVQALCLPLDK 230
+ + + + L+N R+ + L ++ + T E H Q+ + A++QL++ Q L +
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER-QNKELKVKL 1794
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEEL---- 286
+ E +++ ++ SI +L+ L L +E + AC + + L
Sbjct: 1795 QEMEGTVKSKYKASIT--ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 287 -----ARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQ 330
A + ++ + L+RQ EA++ + + +++K+++E +
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 53.9 bits (128), Expect = 3e-07
Identities = 91/367 (24%), Positives = 149/367 (40%), Gaps = 45/367 (12%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTA----SQSNLTKELNFTTRAKDAIMQMWLNA 105
G ST++ LQA ER AE + ++L L A SQ +E R + Q A
Sbjct: 957 GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRA 1016
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAII-------LSEKQCRDQFKDMNKSCDAL- 157
+ DL A+ + + N QR A + L+EK+ +DQ + +A
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 158 ---LFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA 214
L L Q VK L+ ++AK++ K+ S + A + E E
Sbjct: 1077 IKELEELRQTVKQLKEQLAKKE----KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
Query: 215 KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPR---SLDNLGYNLYHPLGS------EL 265
++Q QK Q L++ RDS + L+ L H + EL
Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
Query: 266 ASIR-RACDHMPSLMSSKVE------------ELARSLRADIERVARENSDLQRQKLEAQ 312
A+ R + DH + K + L SL ++ + R+ + + + E +
Sbjct: 1193 AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
Query: 313 QGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREA 372
+ + A E QK+E+ R LQAE + + A E + LR+E +L +E E+++ +
Sbjct: 1253 RLVMAESEKSQKLEE----RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS 1308
Query: 373 EQLRMEL 379
E LR EL
Sbjct: 1309 ENLRQEL 1315
Score = 49.3 bits (116), Expect = 7e-06
Identities = 67/283 (23%), Positives = 121/283 (42%), Gaps = 37/283 (13%)
Query: 138 LSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK---------TICTKDKESVLL 188
L +K+C ++ N+ L L + + L+ +EK K + + L
Sbjct: 370 LQDKKC---LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426
Query: 189 NKRVAEEQLVECVKTRELQHQERQLAK-----EQLQKVQALCLPLDKDKFEMDLRNLWRD 243
+ VE ++T Q + + LA+ E+ Q++ +L L + + NL
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDL-----QSSISNL--- 478
Query: 244 SIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSD 303
S L+ L +++AS+ + + + + +ELA + E+ A+
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538
Query: 304 LQRQKLEAQQGLR--ASQEAKQKVEKEAQAREAKLQAECSRQTQL-----ALEEKAVLRK 356
LQ+Q+ +A QGLR Q + +KE Q +E + E +RQ A EE+ +
Sbjct: 539 LQQQE-QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597
Query: 357 ERDNLAKELE----EKKREAEQLRMELAIRNSALDTCIKTKSQ 395
ERD K+LE EK + E L+ +L + N A D+ + +Q
Sbjct: 598 ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Score = 39.7 bits (91), Expect = 0.006
Identities = 79/357 (22%), Positives = 142/357 (39%), Gaps = 48/357 (13%)
Query: 64 ERRAEGLYSQLLGLTASQSNLTK---ELNFTTRAKDAIMQMWL-NARRDLDRINASFRQC 119
E + L S + L +S SNL++ EL ++A A + + + +L +NA+ +Q
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517
Query: 120 QGDRVIYTNNQRYMAAIILSEKQCRDQFKD-MNKSCDALLFMLNQKVKTLEVEIAKEKTI 178
+ + A + Q ++Q + + L L QK + L+ E+A+++
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK-EVAEKQEA 576
Query: 179 CTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQA-LCLPLDKDKFEMDL 237
+D +QL + RE +ER A +QL+ ++ L+ + ++ +
Sbjct: 577 TRQDHA----------QQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 238 RNLWRDSI------IPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR 291
N RDS R L + EL + ++V EL LR
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKV-----EELQACVETARQEQHEAQAQVAELELQLR 681
Query: 292 ADI------ERVARENSDLQRQKLEAQQGLRASQ--------------EAKQKVEKEAQA 331
++ ERVA+E LQ Q ++ L+ ++ E +Q+ E +A
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
Query: 332 REAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDT 388
L + R+ + EE+A + L + E + E E LR ELA +A T
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT 798
Score = 39.7 bits (91), Expect = 0.006
Identities = 70/331 (21%), Positives = 131/331 (39%), Gaps = 68/331 (20%)
Query: 60 LQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQC 119
LQ E+ ++GL Q+ L++S ++L ++A RQ
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT------------------RQD 580
Query: 120 QGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTL-EVEIAKEKTI 178
++ +R A + Q + + K A L +L Q+++ E + + ++
Sbjct: 581 HAQQLATAAEER--EASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Query: 179 CTKDKESVLLNKRVAEEQLVECVKT-RELQHQ--------ERQLAKEQLQKVQALCLPLD 229
+E L+++V E+L CV+T R+ QH+ E QL EQ + + + +
Sbjct: 639 TQAQREKAELSRKV--EELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
Query: 230 KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARS 289
KD+ + L+ L + + GS RRA D + + EL
Sbjct: 697 KDQLQEQLQALKESLKVTK-------------GSLEEEKRRAADALEEQQRC-ISELKAE 742
Query: 290 LRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALE 349
R+ +E+ RE +L+ ++ ++GL A ++++ +A +A
Sbjct: 743 TRSLVEQHKRERKELEEERA-GRKGLEA------RLQQLGEAHQA--------------- 780
Query: 350 EKAVLRKERDNLAKELEEKKREAEQLRMELA 380
E VLR+E + E EQL E+A
Sbjct: 781 ETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Score = 39.3 bits (90), Expect = 0.007
Identities = 35/107 (32%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 280 SSKVEELARSLRADIERVARENSDLQRQKLEA--QQGLRASQEAKQKVEKEAQAREAKLQ 337
+ +VEEL++ L AD ++ ++ +Q+QKL+A QG + QEA++ QA+ +LQ
Sbjct: 1548 TKQVEELSKKL-ADSDQASK----VQQQKLKAVQAQGGESQQEAQR-----LQAQLNELQ 1597
Query: 338 AECSRQTQLALEEKAVLRKERDNL------AKELEEKKREAEQLRME 378
A+ S++ Q A K + K + + +EL+E+ R EQL+ E
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Score = 36.6 bits (83), Expect = 0.047
Identities = 85/374 (22%), Positives = 146/374 (39%), Gaps = 47/374 (12%)
Query: 58 SNLQATERRAEGLYSQLLGL-----------TASQSNLTKELNFTTRAKDAIMQMWLNAR 106
S LQ + L S+LL A++ +EL + +A + L A+
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
Query: 107 RDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV- 165
R+L + RQ + Q A + +EK + M K LL N+ +
Sbjct: 1404 RELGEL-IPLRQKVAE-------QERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLG 1455
Query: 166 -------KTLEVEI--AKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKE 216
+ LEVE+ A+EK + R+AE Q REL E AK
Sbjct: 1456 ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL---EVMTAKY 1512
Query: 217 QLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMP 276
+ KV+ L ++ +F+ + + L L +LA +A
Sbjct: 1513 EGAKVKVL---EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQ 1569
Query: 277 SLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKL 336
+ + V+ + + +R+ + ++LQ Q + +Q A++ K ++EK +AK
Sbjct: 1570 QKLKA-VQAQGGESQQEAQRLQAQLNELQAQLSQKEQ---AAEHYKLQMEKAKTHYDAKK 1625
Query: 337 QAECSRQTQL-ALE----EKAVLRKERDNLAKELEE---KKREAEQLRMELAIRNSALDT 388
Q Q QL +LE E LR E + L EL++ K +EAEQ L + +L+
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 389 CIKTKSQPMMPVSR 402
+ Q + + +
Sbjct: 1686 QVAHADQQLRDLGK 1699
Score = 34.7 bits (78), Expect = 0.18
Identities = 68/319 (21%), Positives = 129/319 (40%), Gaps = 35/319 (10%)
Query: 94 AKDAIMQMWLNARRDL-DRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNK 152
AK I+Q L + D S Q Q ++ + + A + + +Q +Q + +
Sbjct: 615 AKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ--EQHEAQAQ 672
Query: 153 SCDALLFMLNQKVKTLEVE-IAKEKTICTKD----KESVLLNKRVAEEQLVECVKTRELQ 207
+ L + +++ K E E +A+EK + KES+ + K EE+ E
Sbjct: 673 VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE-- 730
Query: 208 HQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYN-------LYHP 260
++++ E + ++L +++ E++ R + R L LG L
Sbjct: 731 -EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR-LQQLGEAHQAETEVLRRE 788
Query: 261 LGSELASIRRA---CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRA 317
L +A+ A C+ + +++ E S + + + A L K E ++ +
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 318 SQEAKQKVE----------KEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEE 367
QEAK+KV Q A+L A +R Q E++ +K D+L+ L+E
Sbjct: 849 LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS-TLQE 907
Query: 368 K--KREAEQLRMELAIRNS 384
K E R+E +R +
Sbjct: 908 KMAATSKEVARLETLVRKA 926
Score = 30.0 bits (66), Expect = 4.4
Identities = 63/306 (20%), Positives = 108/306 (35%), Gaps = 61/306 (19%)
Query: 133 MAAIILSEKQC----------RDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKD 182
MAA +E +C R++++D + M +++ TL+ E K + +
Sbjct: 793 MAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA 852
Query: 183 KESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKD------KFEMD 236
KE V + +E Q+ H A +Q+Q+ + L D K
Sbjct: 853 KEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIER 296
+ + R + R L E A RA D P + + S +A ++
Sbjct: 913 SKEVARLETLVRKAGEQQETASRELVKEPA---RAGDRQPEWLEEQQGRQFCSTQAALQA 969
Query: 297 VARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR-QTQLALEEKA--- 352
+ RE + + + L SQ +Q+ + + A+L E R Q LALE+ A
Sbjct: 970 MEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
Query: 353 -------VLRKERDNLA-------------------------------KELEEKKREAEQ 374
L ++R A KELEE ++ +Q
Sbjct: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 375 LRMELA 380
L+ +LA
Sbjct: 1090 LKEQLA 1095
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 52.0 bits (123), Expect = 1e-06
Identities = 68/348 (19%), Positives = 154/348 (44%), Gaps = 9/348 (2%)
Query: 59 NLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQ 118
NL+ T+ + + Y L A S+L++ + + I+ + + ++ ++A +
Sbjct: 897 NLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKA 956
Query: 119 CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTI 178
+ + + A I+S ++C +FK K L QK E E+ K K
Sbjct: 957 QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1016
Query: 179 CTKDKESVLLNKRVAEEQLVECVKTRELQH---QERQLAKEQLQKVQALCLPLDKDKFEM 235
K K+ + ++ ++ V K+ E++ ++ +QL+ + + K ++
Sbjct: 1017 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1076
Query: 236 DLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIE 295
N + S I ++ NL + PL ++ +++++ + + +++ + R + +
Sbjct: 1077 VEENAKQTSEI-LAVQNLLQKQHVPL-EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1134
Query: 296 RVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLR 355
V + + L+ QK + L + K+ EKE +A L+ E ++Q +EE + L+
Sbjct: 1135 TVTKLHQLLENQK-NSSVPLAEHLQIKEAFEKEVGIIKASLR-EKEEESQNKMEEVSKLQ 1192
Query: 356 KERDNLAKELEE-KKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSR 402
E N + L++ + RE L A + S L+T I + ++ + ++R
Sbjct: 1193 SEVQNTKQALKKLETREVVDLSKYKATK-SDLETQISSLNEKLANLNR 1239
Score = 35.0 bits (79), Expect = 0.14
Identities = 47/245 (19%), Positives = 98/245 (40%), Gaps = 15/245 (6%)
Query: 168 LEVEIAKEKTICTKDKESVL-----LNKRVAEEQLV--ECVKTRELQHQERQLAKEQLQK 220
L+ E+ +T C K+ L L +VAE + + EC + +E ++ + ++ L+
Sbjct: 429 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 488
Query: 221 VQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMS 280
VQ + +M L + + + L L +L ++ + + +
Sbjct: 489 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 548
Query: 281 S------KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA 334
+ E + + D ++ EN LQ++ + + ++ ++ E E QA+E
Sbjct: 549 KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE--MEREKKGRKVTEMEGQAKEL 606
Query: 335 KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS 394
+ S + K+ L E + AK+L E +RE E+ E+ L+ +
Sbjct: 607 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
Query: 395 QPMMP 399
Q + P
Sbjct: 667 QHVKP 671
Score = 34.7 bits (78), Expect = 0.18
Identities = 56/273 (20%), Positives = 119/273 (43%), Gaps = 56/273 (20%)
Query: 148 KDMNKSCDALLFMLNQKV-----KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVK 202
+DM KS DA++ LN+K+ K E ++ EK + D L+K V+ +E V
Sbjct: 738 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS----LSKDVSR---LETVF 790
Query: 203 TRELQHQERQLA--------KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLG 254
+H++ +A K+QL +++ C D++K
Sbjct: 791 VPPEKHEKEIIALKSNIVELKKQLSELKKKC-GEDQEKI--------------------- 828
Query: 255 YNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG 314
H L SE ++++ + + + EE+ +L + + RE D++++ + Q
Sbjct: 829 ----HALTSENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQE 883
Query: 315 LRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAV---LRKERDNLAKELEEKKRE 371
++ + +++ + + +++AE + + ++ +RK +D+ A+ L ++
Sbjct: 884 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 943
Query: 372 AEQ---LRMELAIRNSALDT---CIKTKSQPMM 398
E+ L E+ + LDT CIK K P++
Sbjct: 944 QEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV 976
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 52.0 bits (123), Expect = 1e-06
Identities = 68/348 (19%), Positives = 154/348 (44%), Gaps = 9/348 (2%)
Query: 59 NLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQ 118
NL+ T+ + + Y L A S+L++ + + I+ + + ++ ++A +
Sbjct: 910 NLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKA 969
Query: 119 CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTI 178
+ + + A I+S ++C +FK K L QK E E+ K K
Sbjct: 970 QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1029
Query: 179 CTKDKESVLLNKRVAEEQLVECVKTRELQH---QERQLAKEQLQKVQALCLPLDKDKFEM 235
K K+ + ++ ++ V K+ E++ ++ +QL+ + + K ++
Sbjct: 1030 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1089
Query: 236 DLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIE 295
N + S I ++ NL + PL ++ +++++ + + +++ + R + +
Sbjct: 1090 VEENAKQTSEI-LAVQNLLQKQHVPL-EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1147
Query: 296 RVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLR 355
V + + L+ QK + L + K+ EKE +A L+ E ++Q +EE + L+
Sbjct: 1148 TVTKLHQLLENQK-NSSVPLAEHLQIKEAFEKEVGIIKASLR-EKEEESQNKMEEVSKLQ 1205
Query: 356 KERDNLAKELEE-KKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSR 402
E N + L++ + RE L A + S L+T I + ++ + ++R
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATK-SDLETQISSLNEKLANLNR 1252
Score = 35.0 bits (79), Expect = 0.14
Identities = 47/245 (19%), Positives = 98/245 (40%), Gaps = 15/245 (6%)
Query: 168 LEVEIAKEKTICTKDKESVL-----LNKRVAEEQLV--ECVKTRELQHQERQLAKEQLQK 220
L+ E+ +T C K+ L L +VAE + + EC + +E ++ + ++ L+
Sbjct: 442 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 501
Query: 221 VQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMS 280
VQ + +M L + + + L L +L ++ + + +
Sbjct: 502 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 561
Query: 281 S------KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA 334
+ E + + D ++ EN LQ++ + + ++ ++ E E QA+E
Sbjct: 562 KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE--MEREKKGRKVTEMEGQAKEL 619
Query: 335 KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS 394
+ S + K+ L E + AK+L E +RE E+ E+ L+ +
Sbjct: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
Query: 395 QPMMP 399
Q + P
Sbjct: 680 QHVKP 684
Score = 34.7 bits (78), Expect = 0.18
Identities = 56/273 (20%), Positives = 119/273 (43%), Gaps = 56/273 (20%)
Query: 148 KDMNKSCDALLFMLNQKV-----KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVK 202
+DM KS DA++ LN+K+ K E ++ EK + D L+K V+ +E V
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS----LSKDVSR---LETVF 803
Query: 203 TRELQHQERQLA--------KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLG 254
+H++ +A K+QL +++ C D++K
Sbjct: 804 VPPEKHEKEIIALKSNIVELKKQLSELKKKC-GEDQEKI--------------------- 841
Query: 255 YNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG 314
H L SE ++++ + + + EE+ +L + + RE D++++ + Q
Sbjct: 842 ----HALTSENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQE 896
Query: 315 LRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAV---LRKERDNLAKELEEKKRE 371
++ + +++ + + +++AE + + ++ +RK +D+ A+ L ++
Sbjct: 897 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 956
Query: 372 AEQ---LRMELAIRNSALDT---CIKTKSQPMM 398
E+ L E+ + LDT CIK K P++
Sbjct: 957 QEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV 989
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 51.2 bits (121), Expect = 2e-06
Identities = 72/344 (20%), Positives = 146/344 (42%), Gaps = 33/344 (9%)
Query: 59 NLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQ 118
+LQ +++AE L + L A+Q L ++ + ++ +Q RR+L+R + Q
Sbjct: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQ 670
Query: 119 CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEI------ 172
+G R + + + RD + + + + + +E+E+
Sbjct: 671 LEGKRSVLAKELVEVREALSRATLQRDMLQ--AEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 173 AKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDK 232
A+E ++ + LN+ +A+++L +L+ ++ L Q Q Q + ++ +
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788
Query: 233 FEMDLRNLWRDSIIPRSLD---NLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARS 289
+LR + + L+ + L +L ++R H S + ++ +L+R
Sbjct: 789 RLEELR--LEQEVARQGLEGSLRVAEQAQEALEQQLPTLR----HERSQLQEQLAQLSRQ 842
Query: 290 LRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQARE----AKLQAECSRQTQ 345
L + +L++ + EAQ+ + A + A + EKEA A+E A R+ +
Sbjct: 843 L-------SGREQELEQARREAQRQVEALERAAR--EKEALAKEHAGLAVQLVAAEREGR 893
Query: 346 LALEEKAVLRKERDNLAKELEEKKREAEQL---RMELAIRNSAL 386
EE LR E++ L L E +R+ QL R +L AL
Sbjct: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL 937
Score = 46.6 bits (109), Expect = 5e-05
Identities = 64/297 (21%), Positives = 114/297 (38%), Gaps = 55/297 (18%)
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALC 225
+ LE E A+ ++ +++E +L +E+L E + + + E L E +K QAL
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAES-EKQQALS 1065
Query: 226 LPLDKDK---------------FEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRR 270
L + +++ RD+ + D N L SEL +R
Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA---LTSELRDLRA 1122
Query: 271 ACDHMPSLMSSKVEEL-----------------ARSLRADIERVARENSDLQRQKLEAQQ 313
+ + + +V L A LR + + L+R+ LEAQ+
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Query: 314 GLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE 373
LR SQE ++ +EA E R +E+ LR+ + EL ++AE
Sbjct: 1183 KLRESQEGREVQRQEA--------GELRRSLGEGAKEREALRRSNE----ELRSAVKKAE 1230
Query: 374 QLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
R+ L + N + + + V + G + L+E +R LE++R
Sbjct: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGEL-------RTGLQEVERSRLEARR 1280
Score = 38.5 bits (88), Expect = 0.012
Identities = 71/309 (22%), Positives = 130/309 (42%), Gaps = 50/309 (16%)
Query: 60 LQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQC 119
L E L ++ GLT + + + LN +TR K+ +Q L A C
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLN-STRDKNLHLQKALTA-------------C 1759
Query: 120 QGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTIC 179
+ DR + +R AA +Q + + + S + L +V LE++ + +
Sbjct: 1760 EHDRQVL--QERLDAA-----RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL 1812
Query: 180 TKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLR- 238
+ +E + R +E + T + ER+L +E+L +Q L+ +K E++
Sbjct: 1813 QQLREVL----RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSA 1868
Query: 239 -NLWRDSI-IPRSLDNLGYNLYHPLGSELASIRRACD--HMPSLMSSKVEELARSLRA-- 292
L +D + + R+LD + L S ++R + + + ++ ELA + R
Sbjct: 1869 LRLEKDRVALRRTLDKVERE---KLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925
Query: 293 --DIERVARENS--------DLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
+ + V E S D Q+Q+LE QQ + + A+ + E+ +ARE R
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE-----RAHR 1980
Query: 343 QTQLALEEK 351
Q LEE+
Sbjct: 1981 QRVRGLEEQ 1989
Score = 38.1 bits (87), Expect = 0.016
Identities = 50/241 (20%), Positives = 101/241 (41%), Gaps = 50/241 (20%)
Query: 178 ICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDL 237
+ +++K ++ + +VA++Q E + RE + Q A+E+L++ +D+ E +
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQERE----KLQAAQEELRR--------QRDRLEEEQ 647
Query: 238 RNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERV 297
+ +D R EL R + + S +EL +R + R
Sbjct: 648 EDAVQDGARVRR--------------ELERSHRQLEQLEGKRSVLAKELVE-VREALSRA 692
Query: 298 ARENSDLQRQKLEAQQGLRASQEAKQKVE---KEAQAREAKLQAECSR---------QTQ 345
+ LQ +K E + L ++ + ++E + +A EA LQ S+ Q +
Sbjct: 693 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752
Query: 346 LAL--------EEKAVLR---KERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS 394
L L EEK+ L+ ++ + A E++ E+LR+E + L+ ++
Sbjct: 753 LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 395 Q 395
Q
Sbjct: 813 Q 813
Score = 37.4 bits (85), Expect = 0.027
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 40/313 (12%)
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQC---RDQFKDMNKSCDALLFMLN 162
R LD++ R Q +Q ++ + +E + + + K++ + ++ L
Sbjct: 1596 RATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
Query: 163 QKVKTLEVEIAKEKT-ICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKV 221
+ ++LE E+ + + + ++ ++ L RV + L V E++ QL E+L
Sbjct: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRV--DSLQRQVADSEVKAGTLQLTVERLNGA 1713
Query: 222 QALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSS 281
A ++ E LR+ R + + N L AC+H ++
Sbjct: 1714 LAKV-----EESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
Query: 282 KVE----------ELARSLRADIERVARENSDLQRQKLEA--------------QQGLRA 317
+++ + + SL ++ + E +DL+ Q++EA Q+G A
Sbjct: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
Query: 318 SQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAV----LRKERDNLAKELEEKKREAE 373
+ QK++ E + + +L + QL E++ V LR E+D +A K E E
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
Query: 374 QLRM-ELAIRNSA 385
+LR E +R SA
Sbjct: 1889 KLRSHEDTVRLSA 1901
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/130 (28%), Positives = 63/130 (48%), Gaps = 12/130 (9%)
Query: 261 LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQE 320
LG ELA RA +S+ + A +E+ A + L+ Q + + LR
Sbjct: 324 LGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD--KVLREKDL 381
Query: 321 AKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRK--ERDNLAKELEEKKREAEQLRME 378
A+Q+++ + +A L A R T+L L K + ++ E+D + K+L EK E LR++
Sbjct: 382 AQQQMQSDLD--KADLSA---RVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436
Query: 379 LAIRNSALDT 388
+AL+T
Sbjct: 437 ---EQAALET 443
Score = 35.0 bits (79), Expect = 0.14
Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 304 LQRQKLEAQQGLRASQEAKQKV-EKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLA 362
L++Q +++ RA +E Q++ +K A +A A+ R+ Q +L +E+ NLA
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQ--REVQRLRSANELLSREKSNLA 609
Query: 363 KELEEKKREAEQLRME 378
L+ +++AE+LR E
Sbjct: 610 HSLQVAQQQAEELRQE 625
Score = 34.3 bits (77), Expect = 0.23
Identities = 34/115 (29%), Positives = 52/115 (45%), Gaps = 9/115 (7%)
Query: 261 LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQE 320
L +L +R D E+ R LR+ E ++RE S+L AQQ ++E
Sbjct: 566 LEEQLQRLRDKTDGAMQAHEDAQREVQR-LRSANELLSREKSNLAHSLQVAQQ---QAEE 621
Query: 321 AKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQL 375
+Q+ EK A+E E RQ EE+ ++ + +ELE R+ EQL
Sbjct: 622 LRQEREKLQAAQE-----ELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671
Score = 32.7 bits (73), Expect = 0.68
Identities = 24/80 (30%), Positives = 45/80 (56%), Gaps = 6/80 (7%)
Query: 288 RSLRADIERVARENSDLQRQ--KLEAQQGLRASQEAKQKVEKEAQAREAKLQAE---CSR 342
RS + + + + + S L RQ ++EA++ A+ A+Q + A++ EA+ +
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERD-SATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Query: 343 QTQLALEEKAVLRKERDNLA 362
Q +LAL+E++V R ER+ A
Sbjct: 1578 QAELALQEESVRRSERERRA 1597
Score = 32.3 bits (72), Expect = 0.88
Identities = 51/245 (20%), Positives = 100/245 (40%), Gaps = 36/245 (14%)
Query: 169 EVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQA-LCLP 227
EVE+ E I T + + K + L + + L R++ L + ++ + LP
Sbjct: 10 EVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLP 69
Query: 228 LDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
+ + L+ + ++ + L + LA R D + ++ E L
Sbjct: 70 ATEMASLLSLQE--ENQLLQQELSRVE--------DLLAQSRAERDELAIKYNAVSERLE 119
Query: 288 RSLR---ADIER-----VARENSDLQRQKLEAQ----QGLRASQEAKQKVEKEAQAREAK 335
++LR ++E + R++ +L+RQ E Q + L+A QE +Q+ + Q + K
Sbjct: 120 QALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179
Query: 336 L---QAECSRQTQLALEEKAVLRKER----------DNLAKELEEKKREAEQLRMELAIR 382
+ + CS Q LE L ++R ++ LEE+++ + L A+
Sbjct: 180 ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239
Query: 383 NSALD 387
LD
Sbjct: 240 REQLD 244
Score = 32.0 bits (71), Expect = 1.2
Identities = 31/126 (24%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 297 VARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRK 356
V R+ + ++KL+ Q+G ++E + E K Q + +R +L LE R
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE---AARA 1396
Query: 357 ERDNLAKELEEKKREAEQLRMELA---IRNSALDT---CIKTKSQPMMPVSRPMGPVPNP 410
E L L + A+ L ELA ++ A + +++ + + + R P P P
Sbjct: 1397 EAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRP 1456
Query: 411 QPIDPA 416
P PA
Sbjct: 1457 VPGSPA 1462
Score = 30.8 bits (68), Expect = 2.6
Identities = 69/335 (20%), Positives = 130/335 (38%), Gaps = 33/335 (9%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E +LQ +R E + +L A ++ L +L R ++ ++ + +L A+
Sbjct: 992 EEDLQRLQREKEAAWREL---EAERAQLQSQLQ---REQEELLARLEAEKEELSEEIAAL 1045
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
+Q + + ++ +++ A + ++ K M L + + + + +E+
Sbjct: 1046 QQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 177 ---TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQ---LQKVQALCLPLDK 230
T+ E L + E + R LQ Q R L K++ L++ + L L
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL-- 1163
Query: 231 DKFEMDLRNLWRDSIIP--RSL--DNLGYNLYHPLGSELA-SIRRACDHMPSLMSSKVEE 285
+ D R+ R ++ R L G + EL S+ +L S E
Sbjct: 1164 -RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE- 1221
Query: 286 LARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQ 345
LR+ +++ E L+ + +Q L +EA+ V KEA LQ E R
Sbjct: 1222 ----LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ-EVERSRL 1276
Query: 346 LALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
A R+E L ++++ E +L ELA
Sbjct: 1277 EA-------RRELQELRRQMKMLDSENTRLGRELA 1304
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1650 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1707 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1762 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1814
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2201
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2202 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2253
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2312
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2420
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2472
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2473 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2507
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2115
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2116 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2171
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2172 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2228 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2481 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2600 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2652
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2653 VSAQRLQEAGI 2663
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1478 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1751 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1986 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2022
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1567 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1676 RGKAEEQAVRQR-ELA 1690
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1949 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 2008 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2062
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2180
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2181 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2229
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1972 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2025
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2077
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2078 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2107
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2108 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2165
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTT 2190
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1668 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1318
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1564
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1565 VALETAQRSAEAELQSKRAS 1584
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1654 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1711 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1765
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1766 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1818
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1858
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2205
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2206 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2257
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2316
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2369
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2424
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2476
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2477 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2511
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2119
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2120 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2175
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2176 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2232 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2426 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2484
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2485 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2604 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2656
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2657 VSAQRLQEAGI 2667
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1482 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1755 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1869
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1990 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2026
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1571 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1679
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1680 RGKAEEQAVRQR-ELA 1694
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1953 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 2012 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2066
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2126
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2184
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2185 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2233
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1976 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2029
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2081
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2082 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2111
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2112 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2169
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTT 2194
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1551
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1672 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1204 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1264 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1322
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1568
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1569 VALETAQRSAEAELQSKRAS 1588
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1650 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1707 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1762 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1814
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2201
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2202 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2253
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2312
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2420
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2472
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2473 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2507
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2115
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2116 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2171
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2172 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2228 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2481 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2600 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2652
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2653 VSAQRLQEAGI 2663
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1478 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1751 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1986 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2022
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1567 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1676 RGKAEEQAVRQR-ELA 1690
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1949 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 2008 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2062
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2180
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2181 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2229
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1972 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2025
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2077
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2078 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2107
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2108 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2165
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTT 2190
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1668 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1318
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1564
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1565 VALETAQRSAEAELQSKRAS 1584
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1618 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1675 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1729
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1730 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1782
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1822
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2169
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2170 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2221
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2280
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2333
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2388
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2440
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2441 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2475
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2083
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2084 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2139
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2140 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2196 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2390 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2448
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2449 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2568 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2620
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2621 VSAQRLQEAGI 2631
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1446 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1719 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1954 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 1990
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1535 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1643
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1644 RGKAEEQAVRQR-ELA 1658
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1917 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 1976 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2030
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2090
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2148
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2149 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2197
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1940 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 1993
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2045
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2046 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2075
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2076 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2133
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTT 2158
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1515
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1636 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1168 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1228 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1286
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1287 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1532
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1533 VALETAQRSAEAELQSKRAS 1552
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1787 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1844 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1899 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1951
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2338
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2339 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2390
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2449
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2502
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2557
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2609
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2610 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2644
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2252
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2253 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2308
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2309 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2365 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2559 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2617
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2618 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2737 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2789
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2790 VSAQRLQEAGI 2800
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1615 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1888 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 2002
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 2123 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2159
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1704 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1812
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1813 RGKAEEQAVRQR-ELA 1827
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 2086 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 2145 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2199
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2259
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2317
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2318 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2366
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 2109 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2162
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2214
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2215 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2244
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2245 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2302
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTT 2327
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1684
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1805 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1397 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1455
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1701
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1702 VALETAQRSAEAELQSKRAS 1721
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1628 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1685 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1739
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1740 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1792
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2179
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2180 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2231
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2290
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2343
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2398
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2450
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2451 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2485
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2093
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2094 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2149
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2150 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2206 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2400 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2458
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2459 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2578 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2630
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2631 VSAQRLQEAGI 2641
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1456 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1729 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1843
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1964 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2000
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1545 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1653
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1654 RGKAEEQAVRQR-ELA 1668
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1927 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 1986 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2040
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2158
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2159 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2207
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1950 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2003
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2055
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2056 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2085
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2086 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2143
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTT 2168
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1525
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1646 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1238 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1296
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1297 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1542
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1543 VALETAQRSAEAELQSKRAS 1562
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1636 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1693 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1747
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1748 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1800
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2187
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2188 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2239
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2240 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2298
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2351
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2406
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2458
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2459 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2493
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2101
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2102 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2157
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2158 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2214 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2408 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2466
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2467 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2586 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2638
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2639 VSAQRLQEAGI 2649
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1464 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1737 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1851
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 1972 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2008
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1553 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1661
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1662 RGKAEEQAVRQR-ELA 1676
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1935 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1993
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 1994 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2048
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2108
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2166
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2167 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2215
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1958 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2011
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2063
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2064 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2093
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2094 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2151
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTT 2176
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1533
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1654 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1186 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1246 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1304
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1305 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1550
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1551 VALETAQRSAEAELQSKRAS 1570
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 24/220 (10%)
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDK 230
E+A++K++ + E K AE + K E ++R+LA+++L+K + L +
Sbjct: 1677 EVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR-- 288
+ + ++ I R+ G L ELA ++R ELA+
Sbjct: 1734 QRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1788
Query: 289 -------SLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
+ +A E +R S+ +Q+LEA+ G R + A++ A A EAK
Sbjct: 1789 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEEAK------ 1841
Query: 342 RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
RQ QLA E+ A R E + + E EA +L+ E I
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
Score = 46.6 bits (109), Expect = 5e-05
Identities = 88/397 (22%), Positives = 164/397 (41%), Gaps = 60/397 (15%)
Query: 61 QATERRAEGLYSQLLGLTASQSNLTKELNF---TTRAKDAIMQMWLNARRDLDRINASFR 117
Q RRA+ + L A+ + + K F T R K + Q R L+ +
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-- 2228
Query: 118 QCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKT 177
++ QR A + +Q R Q ++ S + L++ +E E +
Sbjct: 2229 ----KNLLDEELQRLKAEATEAARQ-RSQVEEELFSVRVQMEELSKLKARIEAE---NRA 2280
Query: 178 ICTKDK--------ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD 229
+ +DK E K+VAEE V +E RQLA+E L + +AL +
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL-RQLAEEDLAQQRALAEKML 2339
Query: 230 KDKFE--MDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELA 287
K+K + + L ++ + + L + ++ + M ++ + +
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQE-------QARRLQEDKEQMAQQLAEETQGFQ 2392
Query: 288 RSLRADIERVARENSDLQRQKLEAQQGLRA---SQEAKQKVEKEAQAREAKLQAECSRQT 344
R+L A+ +R +++ +R KL + RA ++E Q+ K+A+ KL +T
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-----RT 2447
Query: 345 QLALEEKAVL-------RKERDNLAKELEEK----KREAEQLRMELAIRNSALDTCIKTK 393
+LA +EK L R++ D+ A+ L E +RE E+L+ E + ++ K
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL--------LQLK 2499
Query: 394 SQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
S+ M V + + Q + + L E K +L+ +R
Sbjct: 2500 SEEMQTVQQEQ-LLQETQALQQSFLSE-KDSLLQRER 2534
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/347 (21%), Positives = 146/347 (42%), Gaps = 41/347 (11%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E LQ T ++ + + QL G + +E A++A +Q A + ++ +
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEARVQAEREAAQSRRQVEEAE 2142
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
R Q + AA +EK ++ ++ + A L QK + + E+ K K
Sbjct: 2143 RLKQSAEEQAQARAQAQAA---AEKLRKEAEQEAARRAQAEQAALRQK-QAADAEMEKHK 2198
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
K E L K E++L E ++ L E+LQ+++A + + +++
Sbjct: 2199 ----KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 237 LRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR--ADI 294
L+ + L L + A I R D+ + + E++ + A +
Sbjct: 2255 -EELFSVRVQMEELSKLKARIE---AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
Query: 295 ERVARENSDLQRQKLE--AQQGLRASQEAKQKVEKEAQAREAKLQAEC-SRQTQLALEEK 351
A+E + L++ E AQQ A + K+K++ +A K +AE +Q +LA E+
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
Query: 352 AVLRKERDNLAKELEEKKR------------------EAEQLRMELA 380
L+++++ +A++L E+ + EAE+L++ +A
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/251 (23%), Positives = 111/251 (44%), Gaps = 16/251 (6%)
Query: 192 VAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS-----II 246
+A ++ V V+T E+Q Q+ E+L++ A L +K+K + + + L S +
Sbjct: 2449 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQ 2507
Query: 247 PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQR 306
L L SE S+ + + +K+E+L + A +++ E Q+
Sbjct: 2508 QEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566
Query: 307 QKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELE 366
Q + +Q L AS E ++ + EA+ + Q E + Q +++ +L +E L ++L+
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 367 EKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM--GPVPNPQPIDPASLEEFKRK 424
+ EQ R LA +S T + + +P R GP +P S + +RK
Sbjct: 2627 LLE---EQHRAALA--HSEEVTASQVAATKTLPNGRDALDGPAAEAEP--EHSFDGLRRK 2679
Query: 425 ILESQRPPAGI 435
+ + AGI
Sbjct: 2680 VSAQRLQEAGI 2690
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Query: 279 MSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
+ ++++L +S A+I+ AR+ +R +L ++ +R + + E++ E +LQA
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPM 397
+R + A +K ++E + L ++++++ + Q +ELA R A + K + +
Sbjct: 1505 LRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
Score = 43.9 bits (102), Expect = 3e-04
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 26/339 (7%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E L+ + AEG Q L L E + + + + +R+
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
++ + + + M ++ S+ + ++ + ++ L + + L E A+ +
Sbjct: 1778 QELEAE---LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 177 TICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMD 236
+ + K L + A Q E R L + + + K +A +K+
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1892
Query: 237 LRNLWRDSIIPRS-LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELAR------- 288
LR L D R L+ + LA +R+A D VE+ R
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 289 ---SLRADIERVARENSDLQ----RQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQAE 339
+L+A E+ A ++L+ R + A+ LR+ ++A+ + ++ Q A E + + E
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
Query: 340 CSRQTQ--LALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q LA EE+A ++R +E+E K + E+ R
Sbjct: 2013 AEERVQKSLAAEEEAA--RQRKAALEEVERLKAKVEEAR 2049
Score = 42.4 bits (98), Expect = 9e-04
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRS 249
KR AE +L VK +E+Q A LQ ++ L L ++ + + + R + +
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRA---LQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKL 309
L+ + L S+ AS + K +L RSL+ + VA+ + +R+
Sbjct: 1594 LETAQRSAEAELQSKRASF-----------AEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 310 EAQQGLRASQEAKQKVEK-EAQAREA---KLQA-ECSRQTQLALEEKAVLRKERDNLAKE 364
+ + RA +EA++++E+ + +A EA +LQA E ++Q LA E ++E + A+
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1702
Query: 365 LEEKKREAEQLRMELA 380
+ + +A + R ELA
Sbjct: 1703 RGKAEEQAVRQR-ELA 1717
Score = 41.6 bits (96), Expect = 0.001
Identities = 67/352 (19%), Positives = 150/352 (42%), Gaps = 40/352 (11%)
Query: 50 GNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKE----LNFTTRAKDAIMQMWLNA 105
G + + E L++ E+ AE ++ L A + +E + + A++ + A
Sbjct: 1976 GRIRSNAEDTLRSKEQ-AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2034
Query: 106 RRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKV 165
+++R+ A + + R+ Q + L+++ + + + K A F + QK
Sbjct: 2035 LEEVERLKAKVEEAR--RLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKE 2089
Query: 166 KTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT--------RELQHQER--QLAK 215
+ L+ + +E+++ + + +R AEE V+ R+++ ER Q A+
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
Query: 216 EQLQ---KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC 272
EQ Q + QA L K+ + R + R + ++R+
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2207
Query: 273 DHMPSLMSSKVEELARSLRADIERVARENS----DLQRQKLEAQQGLRASQEAKQKVEKE 328
++VE+ +LR +E + + +LQR K EA + R + +VE+E
Sbjct: 2208 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEE 2256
Query: 329 AQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+ +++ + ++ E +A++ +++DN + L+E+ + +Q+ E A
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/265 (25%), Positives = 112/265 (42%), Gaps = 52/265 (19%)
Query: 130 QRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLN 189
QR +AA E++ R+ + + KS A Q+ LE E+ + K K +E+ L
Sbjct: 1999 QRQLAAE--EERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA---KVEEARRLR 2052
Query: 190 KRVAEE-----QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDS 244
+R +E QL + + LQ +E+ A QK Q L L +++ +D
Sbjct: 2053 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD-------- 2104
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDL 304
L E + RRA + A R ER A ++
Sbjct: 2105 ---------------QLRGEAEAARRAAEE------------AEEARVQAEREAAQS--- 2134
Query: 305 QRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT-QLALEEKAVLRKERDNLAK 363
R+++E + L+ S E + + +AQA KL+ E ++ + A E+A LR+++ A
Sbjct: 2135 -RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA- 2192
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
E+E+ K+ AEQ + A L T
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTT 2217
Score = 39.3 bits (90), Expect = 0.007
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 17/112 (15%)
Query: 284 EELARSLRADI-ERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
E LA RA+ ER+A + L++Q+ A+ A +AK + E+EA+ + ++Q E R
Sbjct: 1375 ERLAEQQRAEERERLAEVEAALEKQRQLAE----AHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 343 QTQLAL---EEKAVLRKE----RDNLAKELEEKKREAE-----QLRMELAIR 382
+ + A+ ++K +++E R + E++ K R+AE +LR+E IR
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Score = 37.0 bits (84), Expect = 0.036
Identities = 77/356 (21%), Positives = 142/356 (39%), Gaps = 38/356 (10%)
Query: 55 STESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINA 114
S+E+ +QA R+AE L + + +L T R + R + A
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514
Query: 115 SFRQCQGD-----RVIYTNNQRY------MAAIILSEKQCRDQFKDMNKSCDALLFMLNQ 163
RQ Q + R + +QR +A+ + +E + + + ++ + L +
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1574
Query: 164 ---KVKTLEVEIAKEKTICT----KDKESVLLNKRVA-EEQLVECVKTRELQH----QER 211
+++ EVE A++ + + E+ L +KR + E+ + ++ + +H Q R
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRA 271
+ A+ + Q+ ++ + E++ L + + L L A ++
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Query: 272 CDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLE--AQQGLRASQEA---KQKVE 326
+ K EE A R +A + + QRQ E AQQ L A QE + + E
Sbjct: 1695 EAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
Query: 327 KEAQARE------AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
+ Q R+ A+LQ E + TQ E +A L K R + L K R E+ R
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Score = 34.3 bits (77), Expect = 0.23
Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 29/176 (16%)
Query: 248 RSLDNLGYNLYH------PLGSELASIRRACDH---MPSLMSSKVEELARSLRADIERVA 298
R L+ LG L + PLG+ L RR + MP S V E R +A +E +
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286
Query: 299 RENSDLQRQKLEAQQGLRASQEAK-----QKVEKEAQAREAKLQAECSRQTQLALEEKAV 353
R ++ + A+Q + A ++ + K + E A AK + + ++ ++E
Sbjct: 1287 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-KPKVQSGSESVIQEYVD 1345
Query: 354 LRKERDNLA--------------KELEEKKREAEQLRMELAIRNSALDTCIKTKSQ 395
LR L + +EE++R AEQ R E R + ++ ++ + Q
Sbjct: 1346 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 31/140 (22%)
Query: 282 KVEELARSLRADIERVARENS----DLQRQKLEAQ----QGLRASQEA---KQKVEKEAQ 330
++EE R +R +E R+ +LQ + A+ Q +A +EA +++V+ E+Q
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535
Query: 331 ---------AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE-------Q 374
A K +AE +R+ Q AL+ LR + A+E E + R+AE Q
Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQVQ 1591
Query: 375 LRMELAIRNSALDTCIKTKS 394
+ +E A R++ + K S
Sbjct: 1592 VALETAQRSAEAELQSKRAS 1611
Score = 32.3 bits (72), Expect = 0.88
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 17/115 (14%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQ---QGLRASQEA-------------KQKV 325
+ +EL + ++ ++ R D Q+QK Q Q LR S EA + ++
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475
Query: 326 EKEAQAREAKLQAECS-RQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
E + R +LQ E + RQ A E LR + + + + EAE+LR ++
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 50.8 bits (120), Expect = 2e-06
Identities = 74/322 (22%), Positives = 133/322 (41%), Gaps = 35/322 (10%)
Query: 60 LQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQC 119
L+A +++ L LT Q+NL KE A + +M LN+RR + RQ
Sbjct: 247 LEALRLSLSNMHTAQLELT--QANLQKEKE---TALTELREM-LNSRRAQELALLQSRQQ 300
Query: 120 QGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTIC 179
++ + R ++L +C + ++ + + + Q VKTL+ + EK +C
Sbjct: 301 HELELLREQHAREKEEVVL---RCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLC 357
Query: 180 TKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRN 239
++ L K +E + ++ +EL Q +L K + DK++ E LRN
Sbjct: 358 LENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEK----------IFQDKNQAERALRN 407
Query: 240 LWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVAR 299
L +S +++ L +L G L + K +E + + ++E +
Sbjct: 408 L--ESHHQAAIEKLREDLQSEHGRCLED-----------LEFKFKESEKEKQLELENLQA 454
Query: 300 ENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR---QTQLALEEKAVLRK 356
DL+ Q E + L + ++ + +E +L A SR QL EK
Sbjct: 455 SYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHES 514
Query: 357 ERDNLAKELEEKKREAEQLRME 378
E + L E+K R+AE+ E
Sbjct: 515 ELEQLRIYFEKKLRDAEKTYQE 536
Score = 38.9 bits (89), Expect = 0.009
Identities = 62/256 (24%), Positives = 108/256 (42%), Gaps = 32/256 (12%)
Query: 154 CDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVE-----CV-KTRELQ 207
C+ALL ++ L+ ++A EK+ T + L ++R+ EQL + CV + +
Sbjct: 2729 CEALLAQERSQLSELQKDLAAEKSR-TLELSEALRHERLLTEQLSQRTQEACVHQDTQAH 2787
Query: 208 HQERQLAKEQLQKVQALCLPLDK---------DKFEMDLRN----LWRDSIIPRSLDNLG 254
H Q KE+ +V L L+K + E + + L R+ + +L +
Sbjct: 2788 HALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTV 2847
Query: 255 YNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG 314
L+ S+ R + P+ + +++E+ L+ R A S RQ A +
Sbjct: 2848 EALHTQKRELRCSLEREREK-PAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQ 2906
Query: 315 LRASQEAKQKV-EKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNL----------AK 363
R Q K+K+ E E Q + + + +QT LE K + R +L A
Sbjct: 2907 WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDAD 2966
Query: 364 ELEEKKREAEQLRMEL 379
L E++RE E +R L
Sbjct: 2967 HLREQQRELEAMRQRL 2982
Score = 37.0 bits (84), Expect = 0.036
Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 60/283 (21%)
Query: 161 LNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVE-------CVKTRE----LQHQ 209
L ++V+ L E ++ + KD+ ++L ++ E +L E C K E L+ Q
Sbjct: 1407 LRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQ 1466
Query: 210 ERQLAKE-----QLQKVQALCLPLDKDKFEMDLRNL------------W--RDSI---IP 247
L K Q QA ++++F+ +++ L W RDS +
Sbjct: 1467 VASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLD 1526
Query: 248 RSLDNLGYNLYHPLG--SELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQ 305
++ L L L +ELA + + D + +++ L ++VA+ +++
Sbjct: 1527 GEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVE 1586
Query: 306 RQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR---------------QTQLALEE 350
+QK +GL +E +K + + + LQ+ + QL + +
Sbjct: 1587 KQK-NIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ 1645
Query: 351 KAVLRKE------RDNLAK---ELEEKKREAEQLRMELAIRNS 384
+A+LR+E ++ L K +LE K E L ++L ++NS
Sbjct: 1646 RALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNS 1688
Score = 36.2 bits (82), Expect = 0.061
Identities = 55/251 (21%), Positives = 97/251 (38%), Gaps = 45/251 (17%)
Query: 167 TLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQER--------------- 211
+LE + A+ +C K + +E +E + L QER
Sbjct: 2693 SLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKS 2752
Query: 212 ------------QLAKEQL-QKVQALCLPLDKDKFEMDLRNLWRDSI----IPRSLDNLG 254
+L EQL Q+ Q C+ D L+ L + + L+ +
Sbjct: 2753 RTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQ 2812
Query: 255 YNLYHPLGSELASIRRACD------HMPSLMSSKVEEL---ARSLRADIERVARENSDLQ 305
H A ++ C+ + + + S VE L R LR +ER RE
Sbjct: 2813 QQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLER-EREKPAWL 2871
Query: 306 RQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEE--KAVLRKERD-NLA 362
+ +LE QE ++ + A+AR++ AE R+ Q E+ + L+++RD +
Sbjct: 2872 QAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKI 2931
Query: 363 KELEEKKREAE 373
K+L++ R+ E
Sbjct: 2932 KQLQQTVRDLE 2942
Score = 35.4 bits (80), Expect = 0.10
Identities = 54/234 (23%), Positives = 99/234 (42%), Gaps = 32/234 (13%)
Query: 165 VKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQAL 224
++ LE E K I T+ E L + LQ +++L KE+ ++++ L
Sbjct: 1694 LRELEEENTSLKVIYTRSSEIEELKATI-----------ENLQENQKRLQKEKAEEIEQL 1742
Query: 225 CLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVE 284
++K + E+ L ++ D+ +L SEL + +L
Sbjct: 1743 HEVIEKLQHELSLMG----PVVHEVSDSQAGSLQ----SELLCSQAGGPRGQALQGEL-- 1792
Query: 285 ELARSLRADIERVARENSDLQRQKLEA-QQGLRASQEAKQ----KVEKEAQAREAKLQAE 339
E A + + R+ + Q LEA QQ L+ ++EA + ++E+ REA+++
Sbjct: 1793 EAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDM 1852
Query: 340 CSR--QTQLALEEKAVLRKERDNLAKELEEKK----REAEQLRMELAIRNSALD 387
SR + + AL+ K ER+ L ++K E E + + LA AL+
Sbjct: 1853 ASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALE 1906
Score = 35.0 bits (79), Expect = 0.14
Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 13/122 (10%)
Query: 280 SSKVEELARSL---RADIERVARENSDLQRQ---KLEAQQGLRASQEAKQKVEKEAQARE 333
S+ ELA L + +E E +DL+ K +++ L E+ ++ ++A +
Sbjct: 1320 SAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQ 1379
Query: 334 AKLQAECSRQTQL-------ALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
A L+ EC+R A +A LRKE ++L KE E +++AE+ R L + L
Sbjct: 1380 AALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKIL 1439
Query: 387 DT 388
++
Sbjct: 1440 ES 1441
Score = 34.3 bits (77), Expect = 0.23
Identities = 28/124 (22%), Positives = 56/124 (45%), Gaps = 22/124 (17%)
Query: 261 LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGL----- 315
L L +++ + S++SSK EL +L Q+LE++QG
Sbjct: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAAL----------------QELESEQGKGRALQ 2666
Query: 316 -RASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQ 374
+ +E + +++E+Q+ +A + S +TQ A + + + + AK+ +K+ E
Sbjct: 2667 SQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEH 2726
Query: 375 LRME 378
R E
Sbjct: 2727 SRCE 2730
Score = 29.6 bits (65), Expect = 5.7
Identities = 51/239 (21%), Positives = 98/239 (41%), Gaps = 50/239 (20%)
Query: 140 EKQCRDQFKDMNKSCDALLFMLNQKVKTLE----VEIAKEKTICTKDKESVLLNKRVAEE 195
E+ R F+ ++ + D L+ M + LE + EK K++E+ + ++ +
Sbjct: 1253 EQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRK--HQ 1310
Query: 196 QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGY 255
+L+EC+K E L +L K Q + F+++ +L ++ D+
Sbjct: 1311 ELLECLKEESAAKAELAL---ELHKTQGTL-----EGFKVETADL--KEVLAGKEDS--- 1357
Query: 256 NLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGL 315
H L EL S+RR +++ A+E + L+ + L
Sbjct: 1358 --EHRLVLELESLRR----------------------QLQQAAQEQAALREECTR----L 1389
Query: 316 RASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQ 374
+ EA +A+AREA L+ E T+ E + K+R L +++ + E E+
Sbjct: 1390 WSRGEA---TATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEE 1445
Score = 28.9 bits (63), Expect = 9.8
Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 27/214 (12%)
Query: 175 EKTICTKDKESVLLNKRVAEEQL-----VECVKTRELQHQERQLAKEQLQKVQAL----- 224
E T + K+ LL RVAE Q + ++TR L + L L + Q +
Sbjct: 929 ELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD-SLESCYLSEFQTIREEHR 987
Query: 225 -CLPLDKDKFEMDLRNLWR-DSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSK 282
L L + FE LW+ DS+ L L EL S+R DH+ + +S+
Sbjct: 988 QALELLRADFE---EQLWKKDSLHQTILTQELEKLKRKHEGELQSVR---DHLRTEVST- 1040
Query: 283 VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSR 342
ELA ++ +++ V + +++ L +E + +AQ + + S
Sbjct: 1041 --ELAGTVAHELQGVHQGEFGSEKKT-----ALHEKEETLRLQSAQAQPFHQEEKESLSL 1093
Query: 343 QTQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
Q Q + L+ + +L+ E+EE + E E L+
Sbjct: 1094 QLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQ 1127
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/235 (21%), Positives = 111/235 (47%), Gaps = 43/235 (18%)
Query: 161 LNQKVKTLEVEIAKEKTICTK-DKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQ 219
L Q++ L V++ ++ + + +K+ ++ +AEE+ + E E + A+E+
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE-AREKET 1483
Query: 220 KVQALCLPLD-----KDKFEMDLRNLWRD-SIIPRSLDNLGYNLYHPLGSELASIRRACD 273
K +L L+ K++FE + L D + S D++G N++ EL +RA +
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH-----ELEKSKRALE 1538
Query: 274 HMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQARE 333
M +++EEL + L+A+++AK ++E QA +
Sbjct: 1539 QQVEEMRTQLEEL-------------------------EDELQATEDAKLRLEVNMQAMK 1573
Query: 334 AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKRE-----AEQLRMELAIRN 383
A+ + + + + E+K +L K+ L ELE+++++ A + +ME+ +++
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Score = 48.5 bits (114), Expect = 1e-05
Identities = 67/325 (20%), Positives = 131/325 (40%), Gaps = 59/325 (18%)
Query: 64 ERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDR 123
ER+ + L + + L +S+ ++ K ++ ++K A+ Q R L+ + + + +
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 124 VIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDK 183
+ N + M A + Q RD+ + K +L ++V+ LE E+ E+ K +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKR------LLIKQVRELEAELEDER----KQR 1612
Query: 184 ESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRD 243
+ +K+ E L + E ++ R +QL+K+QA + E++ RD
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR---ELEEARASRD 1669
Query: 244 SIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSD 303
I +S ++ E+ +SL A+I
Sbjct: 1670 EIFAQSKES-------------------------------EKKLKSLEAEI--------- 1689
Query: 304 LQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAK 363
L+ Q+ L +S+ A++ E+E ++ S ++ L L+EK L L +
Sbjct: 1690 -----LQLQEELASSERARRHAEQERDELADEITNSASGKSAL-LDEKRRLEARIAQLEE 1743
Query: 364 ELEEKKREAEQLRMELAIRNSALDT 388
ELEE++ E L +DT
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDT 1768
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/313 (23%), Positives = 133/313 (42%), Gaps = 66/313 (21%)
Query: 139 SEKQCRD----QFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAE 194
SEK R+ Q +D+++ +AL L TL+ A+++ +++E L K + E
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELED---TLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 195 EQLVECVKTRELQHQER--------QLAKEQLQKVQALCLPLDKDK--FEMDLRNLWRDS 244
E K E Q Q+ + EQL++ + L+K+K E D + L +
Sbjct: 1186 E-----TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 245 IIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEEL-ARSLRADIERV--AREN 301
+ L ++ +H + ++V+EL A+ D RV A +
Sbjct: 1241 KV------------------LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 302 SDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQ------AECSRQTQLALEEKAVLR 355
S LQ + L +++ K K+A + E++LQ E +RQ L
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 356 KERDNLAKELEEKKREAEQLRME-LAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPID 414
+E+++L ++ EE++ + L + LA+++ DT K V +G +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK--------VDDDLGTI------- 1387
Query: 415 PASLEEFKRKILE 427
SLEE K+K+L+
Sbjct: 1388 -ESLEEAKKKLLK 1399
Score = 40.4 bits (93), Expect = 0.003
Identities = 54/253 (21%), Positives = 106/253 (41%), Gaps = 13/253 (5%)
Query: 144 RDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKT 203
+DQ ++ D L L +K + L+ +A+ T K + L R + Q+ E +
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQAQIAELQED 1126
Query: 204 RELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGS 263
E + R A++Q + + L K + E L + + L L
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEAL-KTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 264 ELASIRRACDHMPSLMSSKVEELARSL------RADIER----VARENSDLQRQKLEAQQ 313
E + M ++ +EEL+ L +A++E+ + +N +L + QQ
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 314 GLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAE 373
S+ ++K++ + Q AK+ + +LA E+ + L+ E DN++ LEE +++
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA-EKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 374 QLRMELAIRNSAL 386
+ + A S L
Sbjct: 1305 KFAKDAASLESQL 1317
Score = 36.6 bits (83), Expect = 0.047
Identities = 60/289 (20%), Positives = 120/289 (41%), Gaps = 29/289 (10%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E+ ++A + + + QL L A + +EL ++D I + + L + A
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKD-MNKSCDALLFMLNQKVKTLEVEIAK- 174
Q Q + +R+ +Q RD+ D + S +L++K + LE IA+
Sbjct: 1690 LQLQEELASSERARRHA-------EQERDELADEITNSASGKSALLDEK-RRLEARIAQL 1741
Query: 175 EKTICTKDKESVLLNKRVAEEQLVECVKTRELQH-----QERQLAKEQLQKVQALCLPLD 229
E+ + + LLN R + L EL Q+ A++QL++ Q L
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER-QNKELKAK 1800
Query: 230 KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEEL--- 286
+ E +++ ++ +I +L+ L L E A R A + + K++E+
Sbjct: 1801 LQELEGAVKSKFKATI--SALEAKIGQLEEQLEQE-AKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 287 -------ARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKE 328
A + +E+ L+RQ EA++ + +++K+++E
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
Score = 35.0 bits (79), Expect = 0.14
Identities = 52/225 (23%), Positives = 93/225 (41%), Gaps = 57/225 (25%)
Query: 207 QHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELA 266
Q +E Q E+L KV+ ++ + EM+ ++ + L L L +E
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKH--------QQLLEEKNILAEQLQAETE 901
Query: 267 SIRRACDHMPSLMSSK--VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQK 324
A + L + K +EE+ L + +E N LQ +K + Q + Q+ +++
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI---QDLEEQ 958
Query: 325 VEKEAQAR----------EAKLQ---------------------------AECSRQTQLA 347
+++E AR EAK++ AECS +QLA
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS--SQLA 1016
Query: 348 LEEK-----AVLRKERDNLAKELEEKKREAEQLRMELAIRNSALD 387
EE+ A +R +++ + +LEE+ ++ E+ R EL LD
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061
Score = 35.0 bits (79), Expect = 0.14
Identities = 56/244 (22%), Positives = 113/244 (46%), Gaps = 32/244 (13%)
Query: 146 QFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLL-NKRVA-EEQLVECVKT 203
Q +DM + L L+++++ + + K K+K+ + NK +A E ++++ VK
Sbjct: 1193 QIQDMRQRHATALEELSEQLE----QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 204 RELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHP--- 260
E +H+ ++L Q+Q++ A D+ + E+ + S + LDN+ L
Sbjct: 1249 -ESEHKRKKL-DAQVQELHAKVSEGDRLRVEL----AEKASKLQNELDNVSTLLEEAEKK 1302
Query: 261 ---LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRA 317
+ AS+ L+ + + +L + I ++ E + LQ Q+ E
Sbjct: 1303 GIKFAKDAASLESQLQDTQELLQEETRQKL-NLSSRIRQLEEEKNSLQEQQEE------- 1354
Query: 318 SQEAKQKVEK-----EAQAREAKLQAECSRQTQLALEE-KAVLRKERDNLAKELEEKKRE 371
+EA++ +EK ++Q + K + + T +LEE K L K+ + L++ LEEK
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 372 AEQL 375
++L
Sbjct: 1415 YDKL 1418
Score = 33.5 bits (75), Expect = 0.40
Identities = 50/311 (16%), Positives = 130/311 (41%), Gaps = 29/311 (9%)
Query: 77 LTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAI 136
L S L EL+ + + + + +D + + + Q T + +++
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 137 ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQ 196
I ++ ++ ++ + + L ++V L+ ++A K D ++ + A+++
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE-SLEEAKKK 1396
Query: 197 LVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYN 256
L++ + + +E+ LA ++L+K + + + + LD+L +
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTK---------------------NRLQQELDDLTVD 1435
Query: 257 LYHP--LGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG 314
L H + S L ++ D + ++ + ++ + +R E + + + L +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQL----LAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 315 LRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQ 374
L + EAK++ E++ + A ++ S + + + L K + L +++EE + + E+
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVG-KNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 375 LRMELAIRNSA 385
L EL A
Sbjct: 1551 LEDELQATEDA 1561
Score = 28.9 bits (63), Expect = 9.8
Identities = 51/268 (19%), Positives = 117/268 (43%), Gaps = 22/268 (8%)
Query: 138 LSEKQCR--DQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEE 195
+ EKQ + + ++M + LL N + L+ E E ++ + L K+ E
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET--ELFAEAEEMRARLAAKKQELE 921
Query: 196 QLVECVKTRELQHQER-QLAKEQLQKVQALCLPLDKDKFE-------MDLRNLWRDSIIP 247
+++ +++R + +ER Q+ + + +K+QA L++ E + L + ++ I
Sbjct: 922 EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK 981
Query: 248 RSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQ 307
+ + + L S+ ++ LM ++ E + L A+ E A+ + ++ +
Sbjct: 982 KMEEEI--LLLEDQNSKFIKEKK-------LMEDRIAECSSQL-AEEEEKAKNLAKIRNK 1031
Query: 308 KLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEE 367
+ L + ++K +E + + KL E + E +A + + + LAK+ EE
Sbjct: 1032 QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 368 KKREAEQLRMELAIRNSALDTCIKTKSQ 395
+ + E +N+AL + ++Q
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQ 1119
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 49.7 bits (117), Expect = 5e-06
Identities = 71/272 (26%), Positives = 124/272 (45%), Gaps = 48/272 (17%)
Query: 137 ILSEKQCRDQFKDMNKSCDALLFMLNQK------VKTLEVEIAKEKTICTKDKESVLLNK 190
+L +K+ RD+ ++ D+L + K VK LE +I + C + +E + K
Sbjct: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
Query: 191 RVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSL 250
VA V+ K + +E Q KE+L+ +++ +KD+ +R+L + + S
Sbjct: 972 LVA----VKAKKELDSSRKETQTVKEELESLRS-----EKDQLSASMRDLIQGA---ESY 1019
Query: 251 DNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLR---ADIERVARENSDL--- 304
NL L + SE + + + ++E+L R LR E + +N DL
Sbjct: 1020 KNL--LLEYEKQSEQLDVEK---ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLAR 1074
Query: 305 ------QRQKLEAQQGLRASQEAKQKVEKEAQA----REAKLQAECSRQTQLALEEKAVL 354
+ LE Q + Q AK V+KE +A +E K++ + +L E + L
Sbjct: 1075 IETLQSNAKLLEVQ--ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE-ELQVQL 1131
Query: 355 RKERDNLAK---ELEEKKREAEQ---LRMELA 380
+KE+ L K ELE K++A+Q + ME+A
Sbjct: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
Score = 45.1 bits (105), Expect = 1e-04
Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 26/263 (9%)
Query: 158 LFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQ 217
L+ N K+ + + +++++ + KE V+L + + + + + E + + L EQ
Sbjct: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
Query: 218 LQK----------VQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLG---YNLYHPLGSE 264
+QK ++ + + +D E D+ N+ + + SL + NL +
Sbjct: 750 VQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ--AVGESLAKINEEKCNLAFQRDEK 807
Query: 265 LASIRRACDHMPSLMSSKVEELARSLRADIER----VARENSDLQRQKLEAQQGLRASQE 320
+ + + + + EEL +SL D E+ + +E ++Q +K Q L +
Sbjct: 808 VLELEKEIKCLQEESVVQCEEL-KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
Query: 321 AKQKVEKEAQ---AREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRM 377
A +K E Q + ++ CS+ +++ E++ KE +NL LE+K E R
Sbjct: 867 ANEKTRLENQNLLIQVEEVSQTCSK-SEIHNEKEKCFIKEHENLKPLLEQK--ELRDRRA 923
Query: 378 ELAIRNSALDTCIKTKSQPMMPV 400
EL + +L K+ P+ V
Sbjct: 924 ELILLKDSLAKSPSVKNDPLSSV 946
Score = 30.4 bits (67), Expect = 3.4
Identities = 66/351 (18%), Positives = 132/351 (37%), Gaps = 42/351 (11%)
Query: 70 LYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQ----------- 118
L QL +Q L+++L F ++D + ++ + ++++I F +
Sbjct: 152 LQKQLEEAMNTQLELSEQLKFQNNSEDNVKKL----QEEIEKIRPGFEEQILYLQKQLDA 207
Query: 119 ---------CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLE 169
Q +I N+Q Y I +++ + L+ + K E
Sbjct: 208 TTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHE 267
Query: 170 VEIAKEKTICTKDKESVLLNKRVAEEQL---VECV-----KTRELQHQERQLAKEQLQKV 221
EI K + KE+++ +E+ + EC K +Q+ Q+ LQ+
Sbjct: 268 AEINKLNEL----KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQEN 323
Query: 222 QALCLPLDKD--KFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLM 279
+ +++ E L+ L I + NL L + I+ H +
Sbjct: 324 TFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL 383
Query: 280 SSKVEELARSLRAD---IERVARENSDLQRQKL-EAQQGLRASQEAKQKVEKEAQAREAK 335
K+ EL + IE++ E + L +Q +Q R Q K++ +KE
Sbjct: 384 EFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNET 443
Query: 336 LQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
++ ++ + E L+++ +NL +E +E E LR + I + L
Sbjct: 444 FLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 49.7 bits (117), Expect = 5e-06
Identities = 70/357 (19%), Positives = 155/357 (43%), Gaps = 39/357 (10%)
Query: 51 NVHVSTESNLQATERRAEGLYS-QLLGLTASQSNLTKELNFTTRAKDAIMQMWLNA---- 105
N + TES+ A R+ + S Q+ L ++ +L + AK + + ++N
Sbjct: 568 NALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSAL 627
Query: 106 ---RRDLDRINASFRQCQGDRVI-----YTNNQRYMAAIILSEKQCRDQFKDMNKSCDAL 157
RRD + QG R+ N + +A + L ++Q +++F D+ K +
Sbjct: 628 ESERRDRTHGSEIINDLQG-RICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNM 686
Query: 158 LFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQ 217
+ ++K ++ + +E+ K + ++ E +E K+ ++ E++L +E+
Sbjct: 687 EIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYES--IEEAKSEAMKEMEKKLLEER 744
Query: 218 L--QKVQALCLPLDK--DKFEMDLRN--------LWRDSIIPRSLDNLGYNLYHPLGSEL 265
QKV+ L L +K + DL+ L + ++ + NL + E
Sbjct: 745 TLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKI------EQ 798
Query: 266 ASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKV 325
+ +R M + + +L+ +++ +EN+ L K+ ++ ++ +Q
Sbjct: 799 ETQKRCLTQNDLKMQT---QQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDA 855
Query: 326 EKEAQAREAKLQAECSRQTQLALEEKAVLRK--ERDNLAKELEEKKREAEQLRMELA 380
+ + + + +L+AE T + + + + E+ L KEL++KK+E + R LA
Sbjct: 856 DGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLA 912
Score = 42.4 bits (98), Expect = 9e-04
Identities = 52/210 (24%), Positives = 87/210 (41%), Gaps = 24/210 (11%)
Query: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQL-QKVQALCLPLDKDKFEMDLRN 239
++ +S+ K +++ + + T E AKE+L QK +++ L+K E++
Sbjct: 429 RETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEI 488
Query: 240 LWRDSIIP--RSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERV 297
R S+ R L+ L H + A +R DH +E SL+ +E +
Sbjct: 489 TLRKSVESALRQLEREKALLQH----KNAEYQRKADHEAD-KKRNLENDVNSLKDQLEDL 543
Query: 298 AR--ENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQ---------- 345
+ +NS + +K+ Q A + E + AR K QAE S+Q Q
Sbjct: 544 KKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQ 603
Query: 346 ----LALEEKAVLRKERDNLAKELEEKKRE 371
L K L KE NL LE ++R+
Sbjct: 604 DKNCLLETAKLKLEKEFINLQSALESERRD 633
Score = 33.9 bits (76), Expect = 0.30
Identities = 71/336 (21%), Positives = 138/336 (41%), Gaps = 39/336 (11%)
Query: 73 QLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRY 132
Q+ L S+ L +E N K + + R++ + ++ Q ++Y
Sbjct: 816 QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQ----LEAEQY 871
Query: 133 MAAIILSEKQCRDQFKDMNKSCDALLFM---LNQKVKTLEVE---IAKEKTICTKDKESV 186
+ + + Q +++ + C+ + L QK + L+ E +A + I +S
Sbjct: 872 FSTLY------KTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE 925
Query: 187 LLNKRVAEEQLVECVKTR---ELQHQERQLA-KEQLQKVQALCLPLDKDKFEM--DLRNL 240
L + +AEEQ + K + EL+ +E K++L + A L++ + D+ NL
Sbjct: 926 QLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANL 985
Query: 241 WRDSI-IPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSK------VEELARSLRAD 293
+ + L ++ L E+++ L++ + V +LA +
Sbjct: 986 ANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK 1045
Query: 294 IERVAREN-SDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKA 352
E V R N +D++R++ E + + E K + EK Q + K Q E + EE
Sbjct: 1046 -EPVKRGNDTDVRRKEKENR---KLHMELKSEREKLTQ-QMIKYQKELNEMQAQIAEESQ 1100
Query: 353 VLRKERDNLAKELEEKKREAEQLRMELAIRNSALDT 388
+ R L L+ K + EQLR +L + LD+
Sbjct: 1101 I----RIELQMTLDSKDSDIEQLRSQLQALHIGLDS 1132
Score = 32.0 bits (71), Expect = 1.2
Identities = 53/282 (18%), Positives = 117/282 (41%), Gaps = 30/282 (10%)
Query: 148 KDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTK----DKESVLLNKRVAEEQLV---EC 200
+++ + C ++ L + K LE EI K++ + ++E LL + AE Q E
Sbjct: 464 EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEA 523
Query: 201 VKTRELQHQERQLAKEQLQ--KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLY 258
K R L++ L K+QL+ K + + +K R L + + R+ + L
Sbjct: 524 DKKRNLENDVNSL-KDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLR 582
Query: 259 HPLGSELASIRRACDHMPSLMSS---------KVEELARSLRADIERVARENS------- 302
I++ + L K+E+ +L++ +E R+ +
Sbjct: 583 KTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIIN 642
Query: 303 DLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLA 362
DLQ + ++ L+ + KVE E + + + ++ + ++ L+ +
Sbjct: 643 DLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKV----IQ 698
Query: 363 KELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPM 404
+ LE+++ E + + LA +N ++ + KS+ M + + +
Sbjct: 699 QSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKL 740
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 49.7 bits (117), Expect = 5e-06
Identities = 61/226 (26%), Positives = 103/226 (45%), Gaps = 32/226 (14%)
Query: 174 KEKTICTKDKESVLLNKRVAEEQLVECVKTREL------------QHQERQLA--KEQLQ 219
+EK KES+L ++R E+Q + R+L Q QER+LA +EQ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 220 KVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLM 279
K + L +D+ D LWR + +E ++ H
Sbjct: 157 KQERL---EQRDRQRRD-EELWR--------QRQEWQEREERRAEEEQLQSCKGHETEEF 204
Query: 280 SSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAR--EAKLQ 337
+ E+L R ++ R RE + Q+Q+ E Q + +E K+ ++E R E KLQ
Sbjct: 205 PDE-EQLRRRELLELRRKGRE--EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 338 -AECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIR 382
E RQ +L EE+ + + ER L +E +E++++ ++LR E +R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Score = 46.6 bits (109), Expect = 5e-05
Identities = 56/203 (27%), Positives = 93/203 (45%), Gaps = 16/203 (7%)
Query: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNL 240
++KE +R E++L + +LQ +ER +QLQ+ + L +D+ +
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERA---QQLQEEED---GLQEDQERRRSQEQ 868
Query: 241 WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARS-----LRADIE 295
RD L+ H L ++ A ++ L+ + EEL R R + E
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPA-LQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 296 RVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLR 355
R RE LQ+ E +Q LR +E +++ E+E Q R+ K + Q L E + R
Sbjct: 928 RQYREEEQLQQ---EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-LGEEPEKRRR 983
Query: 356 KERDNLAKELEEKKREAEQLRME 378
+ER+ +E EE ++E EQL E
Sbjct: 984 QEREKKYREEEELQQEEEQLLRE 1006
Score = 46.6 bits (109), Expect = 5e-05
Identities = 52/193 (26%), Positives = 92/193 (47%), Gaps = 22/193 (11%)
Query: 194 EEQLV-ECVKTRELQHQERQLAKEQ-LQKVQALCLPLDKD-KFEMDLRNLWR-DSIIPRS 249
EEQL+ E + R LQ +ERQ +E+ LQ+ + L +++ + +L +R + + +
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 250 LDNLGYNLYHPLGSELASIRRACDHMPSLMSSKV----EELARSLRADIERVARENSDLQ 305
+ L P R C L + EE + R ++ER RE ++Q
Sbjct: 1090 EEQLLRE--EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 306 RQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKEL 365
+ E +Q LR E +++ E E Q RE + +L EE+ +LR+E++ +E
Sbjct: 1148 Q---EEEQLLREEPEKRRRQELERQYRE---------EEELQQEEEQLLREEQEKRRQER 1195
Query: 366 EEKKREAEQLRME 378
E + RE E+L+ +
Sbjct: 1196 ERQYREEEELQRQ 1208
Score = 46.2 bits (108), Expect = 6e-05
Identities = 51/206 (24%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 190 KRVAEEQLVECVKTRELQHQERQLA-KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPR 248
+R EEQL C H+ + +EQL++ + L L + + R +D +
Sbjct: 186 RRAEEEQLQSCKG-----HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 249 SLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQK 308
+ L E ++ + + E+L + R ++ R R+ + Q+Q+
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR-ERQEEEQQQQR 299
Query: 309 LEAQQGLRASQEAKQKVEKEA--QAREAKLQAECSRQTQLALEEKA----VLRKERDN-- 360
L +Q LR QE +++ ++E + +E + Q E R+ QL E++ LR+E++
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 361 ----LAKELEEKKREAEQLRMELAIR 382
L +E EE++RE +QLR E +R
Sbjct: 360 REQQLRREQEEERRE-QQLRREQQLR 384
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/262 (24%), Positives = 115/262 (43%), Gaps = 44/262 (16%)
Query: 140 EKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNK--------- 190
E+QCR++ +++ + + LL +K + E+E + + +E LL +
Sbjct: 1107 ERQCREE-EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Query: 191 -----------RVAEEQLVECVKTRELQHQERQLAKEQ-LQKVQALCLPLDKDKFEMDLR 238
+ EEQL+ + + Q +ERQ +E+ LQ+ + D+D+ DL+
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDLK 1224
Query: 239 NLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVA 298
W P + + N + G E R+ L S++ + R + D++ +
Sbjct: 1225 WQWE----PEKENAVRDNKVYCKGRENEQFRQ-------LEDSQLRD--RQSQQDLQHLL 1271
Query: 299 RENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKER 358
E + R+ Q+ R Q + E+E RE Q E R+ + + EEK +LR+ER
Sbjct: 1272 GEQQERDRE----QERRRWQQRDRHFPEEEQLEREE--QKEAKRRDRKSQEEKQLLREER 1325
Query: 359 DNLAK--ELEEKKREAEQLRME 378
+ + E + K RE EQL E
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQE 1347
Score = 42.7 bits (99), Expect = 7e-04
Identities = 57/209 (27%), Positives = 92/209 (44%), Gaps = 26/209 (12%)
Query: 183 KESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLW- 241
KE LL + E Q E K R + + + +EQLQ+ + L +++K R
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 242 -RDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKV---------EELARSLR 291
+D + + + L LG E RR ++ EE + R
Sbjct: 961 RKDKKLQQKEEQL-------LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 292 ADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAK-LQAECSRQTQLALEE 350
+ ER R+ +LQ+ E +Q LR +E ++ E+E Q RE + LQ E + QL EE
Sbjct: 1014 QEWERQYRKKDELQQ---EEEQLLREEREKRRLQERERQYREEEELQQE---EEQLLGEE 1067
Query: 351 KAVLRK-ERDNLAKELEEKKREAEQLRME 378
+ R+ E + ++ EE ++E EQL E
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLRE 1096
Score = 41.2 bits (95), Expect = 0.002
Identities = 48/209 (22%), Positives = 93/209 (44%), Gaps = 38/209 (18%)
Query: 169 EVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPL 228
E E +E+ + +++E L + +E+QL RE + + QL K + +K L
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQL-----RREQEERREQLLKREEEK------RL 558
Query: 229 DKDKFEMDLRNLW---RDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEE 285
++++ E L+ RD ++ R + L + E
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEER---------------------RQQRLKREQEER 597
Query: 286 LARSL-RADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT 344
L + L R ++ER+ +E QR K E + R Q K + ++E + ++ + + + R+
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 345 QLALEEKAVLRKERDNLAKELEEKKREAE 373
+L EE+ ++R L +E EE++RE E
Sbjct: 658 RLKREEEEERLEQR--LKREHEEERREQE 684
Score = 38.9 bits (89), Expect = 0.009
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEA-QAREAKLQAECSR 342
+E R R + ++V R+ + +R+ LE +Q LR + K + E++ Q RE + R
Sbjct: 1426 QERDRKFREEEQQVRRQ--ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 343 QTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
+ EE+ + R+ERD +E E + +E E+ +E
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/98 (30%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
+E + R D +R RE L RQ+ E QQ R ++ K ++E++ R+ + + +
Sbjct: 1543 QERGQQRRQDRDRKFREEEQL-RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 344 TQLALEE-KAVLRKERDNLAKELEE--KKREAEQLRME 378
QL +E + LR+ERD +E E+ ++RE +QL +
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Score = 38.5 bits (88), Expect = 0.012
Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 22/198 (11%)
Query: 191 RVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSL 250
R E+QL + R+ +E+QL +++L++ L ++ + LR R I
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI---- 1749
Query: 251 DNLGYNLYHPLGSELASIRRACDHM----PSLMSSKVEELARSLRADIERVARENSDLQR 306
L P E R+ D L + E+ RS +D R RE L R
Sbjct: 1750 --LEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD--RKFREEEQL-R 1804
Query: 307 QKLEAQQGLRASQEAKQKVEKEA---QAREAKLQAECSRQ----TQLALEEKAVLRKERD 359
Q+ E QQ ++ K + E+E + +E +L+ E RQ Q A +EK+ R+E
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS--RREEQ 1862
Query: 360 NLAKELEEKKREAEQLRM 377
L +E E+K+R+ + ++
Sbjct: 1863 ELWQEEEQKRRQERERKL 1880
Score = 38.1 bits (87), Expect = 0.016
Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 6/105 (5%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECS 341
K E+ R R E+ R + + ++ E + R Q+ K+ E+E + R KL+ E
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 342 RQTQLALEEKAVLRKE----RDNLAKELEEKKREAEQLRMELAIR 382
R+ Q E++ LR+E R+ K EE++R ++LR E +R
Sbjct: 497 REQQERREQQ--LRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Score = 37.7 bits (86), Expect = 0.021
Identities = 31/108 (28%), Positives = 57/108 (52%), Gaps = 16/108 (14%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
+E R R + +++ R+ + +R+ L+ +Q LR QE ++K +E Q R+ Q + RQ
Sbjct: 1687 QERDRKFREEEQQLRRQ--ERERKFLQEEQQLRR-QELERKFREEEQLRQETEQEQLRRQ 1743
Query: 344 TQLAL-----------EEKAVLRKERDNLAKELEE--KKREAEQLRME 378
+ EE+ + R+ERD +E E+ ++RE +QLR +
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Score = 37.4 bits (85), Expect = 0.027
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
+E + LR D +R RE L ++ E Q LR + ++ E+E Q R +
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQ--LRRQERDRKFREEEQQLRRQE-------- 1704
Query: 344 TQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
E+ L++E+ +ELE K RE EQLR E
Sbjct: 1705 -----RERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Score = 37.0 bits (84), Expect = 0.036
Identities = 47/225 (20%), Positives = 92/225 (40%), Gaps = 23/225 (10%)
Query: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRN- 239
+++ L + EE+ + ++ + +E+QL +EQ + + + + E LR
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 240 --LWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVE-------ELARSL 290
L R+ + R + + H ++R + + + E + L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 291 RADIERVAREN------SDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQT 344
+ D E RE + + Q+ +Q LR QE +++ + Q E +LQ +
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 345 QLALE-----EKAVLRKERDNLAKELEEKK--REAEQLRMELAIR 382
QL E E+ + R+E L +E E++ RE E+ R +L R
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Score = 37.0 bits (84), Expect = 0.036
Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 8/109 (7%)
Query: 278 LMSSKVEELARSLRADIERVARENSDLQR-QKLEAQQ-GLRASQEAKQKVEKEAQAREAK 335
L S + E + R R+ LQ Q+L Q+ G + Q+ +K +E Q R+ +
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 336 LQAECSRQTQ---LALEEKAVLRKERDNLAKELEEKKREAE---QLRME 378
+ + SRQ + LEE+ V R+E++ E E++ R E QLR E
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Score = 35.8 bits (81), Expect = 0.080
Identities = 24/103 (23%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
EE + R + +E LQ ++ + Q+ L+ +E +K+E++ RE + E +Q
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ---EEEQQ 296
Query: 344 TQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
Q E+ + RK+ + ++ EE++ + E+ + R L
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQL 339
Score = 35.8 bits (81), Expect = 0.080
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 9/83 (10%)
Query: 298 ARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKE 357
A E S+ RQ+L A+ LR +E + + E+ Q + L E EEK R++
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE---------EEKEQRRRQ 823
Query: 358 RDNLAKELEEKKREAEQLRMELA 380
R KEL+ + E + R E A
Sbjct: 824 RREREKELQFLEEEEQLQRRERA 846
Score = 35.4 bits (80), Expect = 0.10
Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 9/102 (8%)
Query: 282 KVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAR---EAKLQA 338
+ +E + LR D +R RE + Q+L Q+ R +E +Q+V ++ + R E + Q
Sbjct: 1400 RCQEREQQLRQDRDRKFRE----EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKK--REAEQLRME 378
R + EE+ + +E L ++ ++K E +QLR +
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Score = 35.4 bits (80), Expect = 0.10
Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 14/94 (14%)
Query: 299 RENSDLQRQK-----LEAQQGLRASQEAKQKVEKEAQAREAK---LQAECS-----RQTQ 345
RE L RQ+ LE +Q LR + ++ E+E +++E + L+ E RQ +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 346 LALEEKAVLRKERDNLAKELEEKK-REAEQLRME 378
EE+ + R+ER ++ ++K RE EQLR E
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Score = 35.4 bits (80), Expect = 0.10
Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 15/159 (9%)
Query: 284 EELARSLRADIERVARENSDL-------QRQKLEAQQGLRASQEAK-QKVEKEAQAREAK 335
+E R R + ++V R+ + Q ++ E QQ LR ++ K ++ E+ Q RE +
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 336 LQAECSRQTQLALEEKAVLRKERD-NLAKELEEKKREAEQLRM---ELAIRNSALDTCIK 391
R + EE + R+ER+ L + + K RE EQL E +R D +
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 392 TKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQR 430
+ Q + R + Q + +E +RK E ++
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQL---RRQELERKFREEEQ 1730
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/100 (28%), Positives = 57/100 (57%), Gaps = 6/100 (6%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAK-QKVEKEAQAREAKL--QAEC 340
E L + LR++ +++ RE + + Q L+ ++ R QE + Q++++E + R +L + E
Sbjct: 526 ERLQQRLRSE-QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 341 SRQTQLALEEKAVL--RKERDNLAKELEEKKREAEQLRME 378
RQ +L E++ L R +R+ + + +E++RE R E
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Score = 34.7 bits (78), Expect = 0.18
Identities = 29/105 (27%), Positives = 52/105 (49%), Gaps = 9/105 (8%)
Query: 283 VEELARSLRADIER-VARENSDLQRQKLEAQ------QGLRASQEAKQKVEKEAQAREAK 335
+EE R R + ER +E L+ Q+ E Q + R ++ + E++ + RE +
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 336 LQAECSRQTQLALEEKAVLRKERDNLAKELEE--KKREAEQLRME 378
Q + + LEE+ LR+ER +E E+ ++RE +QL +
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Score = 33.9 bits (76), Expect = 0.30
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 14/106 (13%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
+E R + +R+ R+ + +R+ L+ +Q LR QE +Q++ ++ + + + + SRQ
Sbjct: 1370 QEQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRC-QEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 344 TQ---LALEEKAVLRKERD--------NLAKELEEKKREAEQLRME 378
+ EE+ V R+ER+ L +E K RE EQL E
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Score = 33.5 bits (75), Expect = 0.40
Identities = 29/112 (25%), Positives = 55/112 (49%), Gaps = 12/112 (10%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
E + LR + E + Q ++ QQ LR+ Q+ +++ E+ RE L+ E ++
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER---REQLLKREEEKR 557
Query: 344 TQLALEEKAVLRKE---RDNLAKELEEK-----KREAEQLRMELAIRNSALD 387
+ E+ + R++ RD L K EE+ KRE E+ R+E ++ ++
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVE 608
Score = 33.1 bits (74), Expect = 0.52
Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 11/111 (9%)
Query: 284 EELARSLRADIERVARENSDLQR-QKLEAQQGLRASQEAK--QKVEKEAQ-AREAKLQAE 339
EE R + E+ R L+R Q+L +Q LR Q+ + Q++ +E Q RE +L+ E
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 340 CSRQTQLALEEKAVLRKERDNLAKELEEK----KREAEQLRMELAIRNSAL 386
Q + E+K + L +E EE+ KRE E R E R L
Sbjct: 429 ---QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Score = 31.2 bits (69), Expect = 2.0
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 12/92 (13%)
Query: 299 RENSDLQRQKLEAQQGLRASQEAKQ----------KVEKEAQAREAKLQAECSRQTQLAL 348
+E + +Q+L ++Q LR QE ++ ++E+E + + K + E R L
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 349 EEKAVLRKERDNLAKELEE--KKREAEQLRME 378
EE+ ++ + + LE+ K+ E E+L E
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Score = 30.4 bits (67), Expect = 3.4
Identities = 47/218 (21%), Positives = 94/218 (43%), Gaps = 26/218 (11%)
Query: 181 KDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNL 240
K +E L + E+QL + R+ +E QL +++ ++ L D+D+ + L
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ----LRHDRDRKFREEEQL 1675
Query: 241 WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIE-RVAR 299
++ + + +L R + + +EL R R + + R
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735
Query: 300 ENSDLQRQ----KLEAQQGLRASQEAKQ--------KVEKEAQAREAKLQAEC-SRQTQL 346
E L+RQ K+ ++ LR +E +Q K +E Q R+ + + + S+++
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 347 ALEEKAVLRKERDNLAKELEEKKR------EAEQLRME 378
E+ LR+ER+ ++L ++R E EQL++E
Sbjct: 1796 KFREEEQLRQEREE--QQLRPQQRDGKYRWEEEQLQLE 1831
Score = 30.0 bits (66), Expect = 4.4
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 14/93 (15%)
Query: 284 EELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQ 343
E+ R LRA+ ER RE L ++ + Q+ + +++ EKE Q E +
Sbjct: 792 EQRERQLRAE-ERQQREQRFLPEEEEKEQR-----RRQRREREKELQFLE--------EE 837
Query: 344 TQLALEEKAVLRKERDNLAKELEEKKREAEQLR 376
QL E+A +E ++ +E +E++R EQ R
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 49.7 bits (117), Expect = 5e-06
Identities = 67/312 (21%), Positives = 134/312 (42%), Gaps = 48/312 (15%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
+ ++ +++ E + Q+ L +++ L EL + ++ + Q + LD+ S
Sbjct: 545 QEDINNNKKQEERMLKQIENLQETETQLRNELEYV---REELKQKRDEVKCKLDK---SE 598
Query: 117 RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEK 176
C R N +Y+ + K + + +K + +N+ LE+E AK+K
Sbjct: 599 ENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKL--ELELESAKQK 656
Query: 177 T-ICTKDKESVLLNKRVAEEQLVECVKTRELQHQE-----RQLAKEQLQKVQALCLPLDK 230
T + + +K+++EE L+E V+ ++ E +++ K K+ + ++K
Sbjct: 657 FGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEK 716
Query: 231 DKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSL 290
K + D II LG L SK +E + SL
Sbjct: 717 HKHQYD-------KIIEERDSELG-----------------------LYKSKEQEQS-SL 745
Query: 291 RADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEE 350
RA +E E S+L+ + L ++ L +E K+K+++EA+ A L+ + ++TQ L E
Sbjct: 746 RASLEI---ELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLE 802
Query: 351 KAVLRKERDNLA 362
+ + D+ A
Sbjct: 803 TPEIYWKLDSKA 814
Score = 35.4 bits (80), Expect = 0.10
Identities = 73/364 (20%), Positives = 146/364 (40%), Gaps = 33/364 (9%)
Query: 60 LQATERRAEGLYSQLLGLTASQSNLTKELN--FTTRAKDAIMQMWLNAR-RDLDRINASF 116
LQA E+ L QL +T S+ +KE+ T + + L + L N
Sbjct: 471 LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKEL 530
Query: 117 RQCQGDRVI--------YTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTL 168
Q D + NN++ ++ + ++ + + + L QK +
Sbjct: 531 TQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEV 590
Query: 169 EVEIAKEKTICTKDKESV-LLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLP 227
+ ++ K + C ++ V NK + E Q ++ + +QL ++ KV L L
Sbjct: 591 KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEI-KVNKLELE 649
Query: 228 LD--KDKFEMDLRNLWRDSIIPRSL--DNLGYNLYHP--LGSELASIRRACDHMPSLMSS 281
L+ K KF ++ + ++ I + + +NL + + E +++ D +
Sbjct: 650 LESAKQKFG-EITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIA 708
Query: 282 KVEELARSLRADIERVARENSD---LQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQA 338
++ L + +++ E L + K + Q LRAS E + +A+ K Q
Sbjct: 709 EMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELS-NLKAELLSVKKQL 767
Query: 339 ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMM 398
E R+ E++ + R+ ++N A E+K ++ + +E LD +K+ P
Sbjct: 768 EIERE-----EKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLD----SKAVPSQ 818
Query: 399 PVSR 402
VSR
Sbjct: 819 TVSR 822
Score = 30.8 bits (68), Expect = 2.6
Identities = 71/364 (19%), Positives = 150/364 (41%), Gaps = 64/364 (17%)
Query: 54 VSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRIN 113
VSTE+ L R+ E + + +Q +EL F ++ + +DL + N
Sbjct: 121 VSTEAEL----RQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKEN 176
Query: 114 ASFRQ-CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALL-------------- 158
+ R C + + ++ R + D+N + + ++
Sbjct: 177 NATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSR 236
Query: 159 ----FMLNQ---KVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQER 211
F L + K++ LE E KE I K+K+ LL ++ E++ K ++L
Sbjct: 237 LEMHFKLKEDYEKIQHLEQEYKKE--INDKEKQVSLLLIQITEKEN----KMKDLTF--- 287
Query: 212 QLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSI-----IPRSLDNLGYNLYHPLGSELA 266
L +E KV L ++K ++ NL + SI + + L+++ +L + ++ A
Sbjct: 288 -LLEESRDKVNQL-----EEKTKLQSENL-KQSIEKQHHLTKELEDIKVSLQRSVSTQKA 340
Query: 267 ---SIRRACDHMPSLMSSKVEELARSLRA---------DIERVARENSDLQRQKLEAQQG 314
++ A + L K ++ S +A + E +L R + QQ
Sbjct: 341 LEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTE---QQR 397
Query: 315 LRASQEAKQKVEKEAQAREAKLQ--AECSRQTQLALEEKAVLRKERDNLAKELEEKKREA 372
L +++ + + E Q + ++L+ + + ++ LEE + E++ L E ++ ++ A
Sbjct: 398 LEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIA 457
Query: 373 EQLR 376
E+L+
Sbjct: 458 EELK 461
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 49.3 bits (116), Expect = 7e-06
Identities = 80/361 (22%), Positives = 151/361 (41%), Gaps = 56/361 (15%)
Query: 55 STESNLQATERRAEGLYSQLL----GLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLD 110
S E + Q E+ E L SQL T L ++L +AK+A+ ++R D D
Sbjct: 1290 SGEFSRQLDEK--EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 111 RINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEV 170
+ + + Q + QR ++ Q R +++ DA+ +T E+
Sbjct: 1348 LLREQYEEEQESKA---ELQRALSKANTEVAQWRTKYET-----DAIQ-------RTEEL 1392
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECV--KTRELQHQERQLAKE------QLQKVQ 222
E AK+K L + A E+ VE V K L+ +++L E +++
Sbjct: 1393 EEAKKK----------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 223 ALCLPLDKDKFEMD-LRNLWRDSIIPRSLD-NLGYNLYHPLGSELASIRRACDHMPSLMS 280
A C LDK + D + W+ + LG+EL I+ A +
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE------ 1496
Query: 281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEK---EAQAREAKLQ 337
+++L +L+ + + + +E SDL Q E + + ++ K++VE+ E QA + +
Sbjct: 1497 -SLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 338 AECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME----LAIRNSALDTCIKTK 393
A + L + L + + + +++ EK E +QL+ + S LD I+++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614
Query: 394 S 394
+
Sbjct: 1615 N 1615
Score = 45.8 bits (107), Expect = 8e-05
Identities = 78/380 (20%), Positives = 159/380 (41%), Gaps = 85/380 (22%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKE---------------------LNFTTRAK 95
E ATE + + L ++ GL + + LTKE +N T+AK
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1030
Query: 96 ----------DAIMQMWLNARRDLDRINASFRQCQGD------RVIYTNNQRYMAAIILS 139
+ ++ R DL+R R+ +GD ++ N++ L
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQ----LD 1083
Query: 140 EKQCRDQFKDMN-----KSCDALLFMLNQKVKTLEVEI--------AKEKTICTKDKESV 186
EK + +F+ N + AL L +K+K L+ I A+ + +K+
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1143
Query: 187 LLNKRVAE--EQLVECVKTRELQHQERQLAKEQLQKVQALC--LPLDKDKFEMDLRNLWR 242
L++ + E E+L E Q + + + + QK++ L + LR
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 243 DSI--IPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE 300
DS+ + +DN L +++ + S M ++++LA +++E V++
Sbjct: 1204 DSVAELGEQIDN------------LQRVKQKLEKEKSEMKMEIDDLA----SNVETVSKA 1247
Query: 301 NSDLQR--QKLEAQ-QGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAV---L 354
+L++ + LE Q L++ +E +Q++ + A+ +LQ E ++ E++A+ L
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307
Query: 355 RKERDNLAKELEEKKREAEQ 374
+ + +++EE KR+ E+
Sbjct: 1308 SRGKQAFTQQIEELKRQLEE 1327
Score = 45.1 bits (105), Expect = 1e-04
Identities = 71/312 (22%), Positives = 136/312 (43%), Gaps = 55/312 (17%)
Query: 134 AAIILSEKQCRDQFKDMNKSCDALLFML----------NQKVKTLEVEIA---------- 173
A + +++ D+ ++ K D L L KVK L E+A
Sbjct: 940 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 999
Query: 174 KEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD--KD 231
KEK + + L + + E+++ K + Q+ + L++ + L + L+ K
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 232 KFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGS---ELASIRRACDHMPSL---------- 278
K E DL+ L ++SI+ ++N L L E+++++ + +L
Sbjct: 1060 KLEGDLK-LAQESIM--DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKE 1116
Query: 279 MSSKVEELARSL---RADIERVARENSDLQRQ------KLEAQQGLRASQ-EAKQKVEKE 328
+ +++EEL + RA + ++ SDL R+ +LE G ++Q E +K E E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176
Query: 329 AQA-----REAKLQAECSRQT--QLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
Q EA LQ E + T + + A L ++ DNL + ++ ++E +++ME+
Sbjct: 1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1236
Query: 382 RNSALDTCIKTK 393
S ++T K K
Sbjct: 1237 LASNVETVSKAK 1248
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/246 (23%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 149 DMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQH 208
D + CD L+ K++ LE +I KE T +D+E + N + K R+L+
Sbjct: 906 DAEERCDQLI---KTKIQ-LEAKI-KEVTERAEDEEEI--NAELT-------AKKRKLED 951
Query: 209 QERQLAKEQLQKVQALCLPLDKDKF--EMDLRNLWRDSI-IPRSLDNLGYN---LYHPLG 262
+ +L K+ + ++ ++K+K E ++NL + + ++ L L
Sbjct: 952 ECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 263 SELASIRRACDHMPSLMSSKV--EELARSLRADIERVARENSDLQRQKLEAQQGLRASQE 320
L ++ D + +L +K+ E+ L +E+ + DL+R K + + L+ +QE
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 321 AKQKVEKEAQAREAKL---QAECSRQTQLALEEKAV---LRKERDNLAKELEEKKREAEQ 374
+ +E E Q + KL + E S +E+A+ L+K+ L +EE + E E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 375 LRMELA 380
R A
Sbjct: 1131 ERASRA 1136
Score = 35.8 bits (81), Expect = 0.080
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 11/105 (10%)
Query: 281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGL-----RASQEAKQKVEKEAQAREAK 335
+K E + L + + +E +DLQ Q +GL R Q K K++ EA+ +E
Sbjct: 870 AKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVT 929
Query: 336 LQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+AE E A L ++ L E E K++ + L + LA
Sbjct: 930 ERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Score = 30.8 bits (68), Expect = 2.6
Identities = 69/351 (19%), Positives = 144/351 (41%), Gaps = 34/351 (9%)
Query: 41 LGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQ 100
LG LF + N + + L+ +R + L ++ LT + K ++ + K + Q
Sbjct: 1483 LGTELFKIK-NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 101 MWLNARRDLDRINASFRQCQGD--RVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALL 158
+ L+ AS +G R+ NQ +++ ++ +++++ +
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV----DRKIAEKDEEIDQLKRNHI 1597
Query: 159 FMLNQKVKTLEVEI-AKEKTICTKDKESVLLNK---------RVAEEQLVECVKTRELQH 208
++ TL+ EI ++ I K K LN+ R+A E L R ++
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL------RNYRN 1651
Query: 209 QERQLAKEQLQKVQALCLPLD-KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELAS 267
+ L Q+ AL D K++ M R R +++ ++ L L S +
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVER---RANLLQAEIEELRATLEQTERSRKIA 1708
Query: 268 IRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEK 327
+ D S +V+ L + I + +D+ + + E + L+ ++ A++K +K
Sbjct: 1709 EQELLD-----ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 328 EAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
+A + AE ++ Q ++K + K+L+ + EAEQL ++
Sbjct: 1764 AIT--DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Score = 28.9 bits (63), Expect = 9.8
Identities = 34/124 (27%), Positives = 52/124 (41%), Gaps = 25/124 (20%)
Query: 283 VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQ----------KVEKEAQAR 332
VE A L+A+IE + +R + A+Q L + E Q +K+ +
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 333 EAKLQAECSRQTQLA--LEEKA------------VLRKERDNLAKELEEKKREAEQLRME 378
+++Q E Q A EEKA L+KE+D A LE K+ EQ +
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTVKD 1798
Query: 379 LAIR 382
L +R
Sbjct: 1799 LQLR 1802
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 49.3 bits (116), Expect = 7e-06
Identities = 80/361 (22%), Positives = 151/361 (41%), Gaps = 56/361 (15%)
Query: 55 STESNLQATERRAEGLYSQLL----GLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLD 110
S E + Q E+ E L SQL T L ++L +AK+A+ ++R D D
Sbjct: 1290 SGEFSRQLDEK--EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 111 RINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEV 170
+ + + Q + QR ++ Q R +++ DA+ +T E+
Sbjct: 1348 LLREQYEEEQESKA---ELQRALSKANTEVAQWRTKYET-----DAIQ-------RTEEL 1392
Query: 171 EIAKEKTICTKDKESVLLNKRVAEEQLVECV--KTRELQHQERQLAKE------QLQKVQ 222
E AK+K L + A E+ VE V K L+ +++L E +++
Sbjct: 1393 EEAKKK----------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 223 ALCLPLDKDKFEMD-LRNLWRDSIIPRSLD-NLGYNLYHPLGSELASIRRACDHMPSLMS 280
A C LDK + D + W+ + LG+EL I+ A +
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE------ 1496
Query: 281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEK---EAQAREAKLQ 337
+++L +L+ + + + +E SDL Q E + + ++ K++VE+ E QA + +
Sbjct: 1497 -SLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 338 AECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME----LAIRNSALDTCIKTK 393
A + L + L + + + +++ EK E +QL+ + S LD I+++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614
Query: 394 S 394
+
Sbjct: 1615 N 1615
Score = 45.8 bits (107), Expect = 8e-05
Identities = 78/380 (20%), Positives = 159/380 (41%), Gaps = 85/380 (22%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKE---------------------LNFTTRAK 95
E ATE + + L ++ GL + + LTKE +N T+AK
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1030
Query: 96 ----------DAIMQMWLNARRDLDRINASFRQCQGD------RVIYTNNQRYMAAIILS 139
+ ++ R DL+R R+ +GD ++ N++ L
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQ----LD 1083
Query: 140 EKQCRDQFKDMN-----KSCDALLFMLNQKVKTLEVEI--------AKEKTICTKDKESV 186
EK + +F+ N + AL L +K+K L+ I A+ + +K+
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1143
Query: 187 LLNKRVAE--EQLVECVKTRELQHQERQLAKEQLQKVQALC--LPLDKDKFEMDLRNLWR 242
L++ + E E+L E Q + + + + QK++ L + LR
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 243 DSI--IPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARE 300
DS+ + +DN L +++ + S M ++++LA +++E V++
Sbjct: 1204 DSVAELGEQIDN------------LQRVKQKLEKEKSEMKMEIDDLA----SNVETVSKA 1247
Query: 301 NSDLQR--QKLEAQ-QGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAV---L 354
+L++ + LE Q L++ +E +Q++ + A+ +LQ E ++ E++A+ L
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307
Query: 355 RKERDNLAKELEEKKREAEQ 374
+ + +++EE KR+ E+
Sbjct: 1308 SRGKQAFTQQIEELKRQLEE 1327
Score = 45.1 bits (105), Expect = 1e-04
Identities = 71/312 (22%), Positives = 136/312 (43%), Gaps = 55/312 (17%)
Query: 134 AAIILSEKQCRDQFKDMNKSCDALLFML----------NQKVKTLEVEIA---------- 173
A + +++ D+ ++ K D L L KVK L E+A
Sbjct: 940 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 999
Query: 174 KEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLD--KD 231
KEK + + L + + E+++ K + Q+ + L++ + L + L+ K
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 232 KFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGS---ELASIRRACDHMPSL---------- 278
K E DL+ L ++SI+ ++N L L E+++++ + +L
Sbjct: 1060 KLEGDLK-LAQESIM--DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKE 1116
Query: 279 MSSKVEELARSL---RADIERVARENSDLQRQ------KLEAQQGLRASQ-EAKQKVEKE 328
+ +++EEL + RA + ++ SDL R+ +LE G ++Q E +K E E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176
Query: 329 AQA-----REAKLQAECSRQT--QLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAI 381
Q EA LQ E + T + + A L ++ DNL + ++ ++E +++ME+
Sbjct: 1177 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1236
Query: 382 RNSALDTCIKTK 393
S ++T K K
Sbjct: 1237 LASNVETVSKAK 1248
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/246 (23%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 149 DMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQH 208
D + CD L+ K++ LE +I KE T +D+E + N + K R+L+
Sbjct: 906 DAEERCDQLI---KTKIQ-LEAKI-KEVTERAEDEEEI--NAELT-------AKKRKLED 951
Query: 209 QERQLAKEQLQKVQALCLPLDKDKF--EMDLRNLWRDSI-IPRSLDNLGYN---LYHPLG 262
+ +L K+ + ++ ++K+K E ++NL + + ++ L L
Sbjct: 952 ECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 263 SELASIRRACDHMPSLMSSKV--EELARSLRADIERVARENSDLQRQKLEAQQGLRASQE 320
L ++ D + +L +K+ E+ L +E+ + DL+R K + + L+ +QE
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 321 AKQKVEKEAQAREAKL---QAECSRQTQLALEEKAV---LRKERDNLAKELEEKKREAEQ 374
+ +E E Q + KL + E S +E+A+ L+K+ L +EE + E E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 375 LRMELA 380
R A
Sbjct: 1131 ERASRA 1136
Score = 35.8 bits (81), Expect = 0.080
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 11/105 (10%)
Query: 281 SKVEELARSLRADIERVARENSDLQRQKLEAQQGL-----RASQEAKQKVEKEAQAREAK 335
+K E + L + + +E +DLQ Q +GL R Q K K++ EA+ +E
Sbjct: 870 AKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVT 929
Query: 336 LQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELA 380
+AE E A L ++ L E E K++ + L + LA
Sbjct: 930 ERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Score = 30.8 bits (68), Expect = 2.6
Identities = 69/351 (19%), Positives = 144/351 (41%), Gaps = 34/351 (9%)
Query: 41 LGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQ 100
LG LF + N + + L+ +R + L ++ LT + K ++ + K + Q
Sbjct: 1483 LGTELFKIK-NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 101 MWLNARRDLDRINASFRQCQGD--RVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALL 158
+ L+ AS +G R+ NQ +++ ++ +++++ +
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV----DRKIAEKDEEIDQLKRNHI 1597
Query: 159 FMLNQKVKTLEVEI-AKEKTICTKDKESVLLNK---------RVAEEQLVECVKTRELQH 208
++ TL+ EI ++ I K K LN+ R+A E L R ++
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL------RNYRN 1651
Query: 209 QERQLAKEQLQKVQALCLPLD-KDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELAS 267
+ L Q+ AL D K++ M R R +++ ++ L L S +
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVER---RANLLQAEIEELRATLEQTERSRKIA 1708
Query: 268 IRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEK 327
+ D S +V+ L + I + +D+ + + E + L+ ++ A++K +K
Sbjct: 1709 EQELLD-----ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 328 EAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
+A + AE ++ Q ++K + K+L+ + EAEQL ++
Sbjct: 1764 AIT--DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Score = 28.9 bits (63), Expect = 9.8
Identities = 34/124 (27%), Positives = 52/124 (41%), Gaps = 25/124 (20%)
Query: 283 VEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQ----------KVEKEAQAR 332
VE A L+A+IE + +R + A+Q L + E Q +K+ +
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 333 EAKLQAECSRQTQLA--LEEKA------------VLRKERDNLAKELEEKKREAEQLRME 378
+++Q E Q A EEKA L+KE+D A LE K+ EQ +
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTVKD 1798
Query: 379 LAIR 382
L +R
Sbjct: 1799 LQLR 1802
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 49.3 bits (116), Expect = 7e-06
Identities = 83/393 (21%), Positives = 163/393 (41%), Gaps = 74/393 (18%)
Query: 57 ESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF 116
E +LQ+ ++ + + + L L + + K I ++ AR+ +
Sbjct: 919 EGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM 978
Query: 117 RQCQGD-----RVIYTNNQRYMAAI---------ILSEKQCRD----QFKDMNKSCDALL 158
R+ D + + T ++ Y A+ L+ K+ D Q + S D+ L
Sbjct: 979 RRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSL 1038
Query: 159 FMLNQKVKTLEVE---IAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAK 215
L+++++ LE E ++ KT+ K+ + V+ E+ E V E + QE + +
Sbjct: 1039 -ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFR 1097
Query: 216 EQLQKVQA----LCLPLDKDKFEMD--------LRNLWRDSIIPRSLDNLGYNLYHPLGS 263
+++++++ L L L+ +K ++ LR +SI+ +L +L L
Sbjct: 1098 KKIKRLEESNKKLALELEHEKGKLTGLGQSNAALRE--HNSILETALAKREADLVQ-LNL 1154
Query: 264 ELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAK- 322
++ ++ + + M V+ L SL + E+V + K+EA R + A
Sbjct: 1155 QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL 1214
Query: 323 --QKVEKEAQARE---AKLQAECSR---------------QTQLA--------------- 347
+V+KE QA+E KLQAE Q +LA
Sbjct: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDE 1274
Query: 348 -LEEKAVLRKERDNLAKELEEKKREAEQLRMEL 379
L ++ V +E +NL E+++K+RE + L+ +L
Sbjct: 1275 QLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL 1307
Score = 38.1 bits (87), Expect = 0.016
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 9/111 (8%)
Query: 280 SSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQ--AREAKLQ 337
S +E A + ++ +V +E L+ Q LEA L ASQ K+K E +AQ A KLQ
Sbjct: 393 SVSLESSAAETQEEMLQVLKEKMRLEGQ-LEALS-LEASQALKEKAELQAQLAALSTKLQ 450
Query: 338 A--ECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSAL 386
A ECS +Q + + L E D L + + +R L+ L +N++L
Sbjct: 451 AQVECSHSSQ---QRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASL 498
Score = 34.7 bits (78), Expect = 0.18
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 2/102 (1%)
Query: 277 SLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKL 336
SL E RS++ + R+A + ++ L+ + QEAK VE++ Q R +
Sbjct: 619 SLSQQLTETQHRSMK-EKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
Query: 337 QAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRME 378
+ E R ++A + A L ++ + + L ++ ++ E L+ E
Sbjct: 678 EGERERLQRMA-DSAASLEQQLEQVKLTLLQRDQQLEALQQE 718
Score = 31.6 bits (70), Expect = 1.5
Identities = 69/311 (22%), Positives = 119/311 (38%), Gaps = 53/311 (17%)
Query: 137 ILSEKQCRD-QFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEE 195
+L K+ D Q K + ++ A L +KV +L+ ++A K ++ + A
Sbjct: 1159 VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHF----KAASL 1214
Query: 196 QLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGY 255
+L E K ELQ +E + K Q +A L + + K ++ + R+ L
Sbjct: 1215 ELSEVKK--ELQAKEHLVQKLQ---AEADDLQIREGKHSQEIAQFQAELAEARAQLQL-- 1267
Query: 256 NLYHPLGSELASIRRACDHMPSLM------SSKVEELARSLRADIERVARENSDLQRQKL 309
L L +L+ M +L +++ L + L ++ +E LQ+
Sbjct: 1268 -LQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQ 1326
Query: 310 EAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKE-RDNLAKELEEK 368
+ L +QE +K+ +AK+ +E + L++ L+ + R AK +E
Sbjct: 1327 NVKSELEMAQEDLSMTQKDKFMLQAKV-SELKNNMKTLLQQNQQLKLDLRRGAAKTRKEP 1385
Query: 369 KREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILES 428
K EA + S P P+ P PV PASL E E
Sbjct: 1386 KGEA-------------------SSSNPATPIKIPDCPV-------PASLLE------EL 1413
Query: 429 QRPPAGIPVAP 439
RPP + P
Sbjct: 1414 LRPPPAVSKEP 1424
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 48.9 bits (115), Expect = 9e-06
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 16/114 (14%)
Query: 274 HMPSLMSSKVEELARSLRA----------DIERVARENSDLQRQKLEAQQGLRASQEAKQ 323
H L K EE R +A + ER +E + +R++ E ++ R QE +Q
Sbjct: 660 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE-RQ 718
Query: 324 KVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRM 377
E+E + + +LQAE Q E + LR +++ L +ELEEKK++ EQ R+
Sbjct: 719 LAEQERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRL 767
Score = 47.0 bits (110), Expect = 3e-05
Identities = 41/129 (31%), Positives = 62/129 (48%), Gaps = 5/129 (3%)
Query: 261 LGSELASIRRACDHMPSLMSS-KVEELARSLR--ADIERVARENSDLQRQKLEAQQGLRA 317
L E A + A M + + K EE AR LR E R LQ++K E Q+ LR
Sbjct: 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
Query: 318 SQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRM 377
+ EAK+ E+ Q R + + E R+ Q E++ R++ LA++ +++E Q
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQER--REQERQLAEQERRREQERLQAER 735
Query: 378 ELAIRNSAL 386
EL R AL
Sbjct: 736 ELQEREKAL 744
Score = 39.3 bits (90), Expect = 0.007
Identities = 60/262 (22%), Positives = 111/262 (42%), Gaps = 26/262 (9%)
Query: 161 LNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAE-EQLVECVKTRELQHQE--RQLAKEQ 217
L ++ + +V A+E+ K+++ + ++ A+ ++ E K L ++ ++ A ++
Sbjct: 572 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 631
Query: 218 LQKVQALCLPLDKDKFEMDLRNL-WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMP 276
+++V+A + K E + R L W + L E R
Sbjct: 632 MEEVEA------RRKQEEEARRLRWLQQ---EEEERRHQELLQKKKEEEQERLRKAAEAK 682
Query: 277 SLMSSKVEELARSLRADIERVARENSDLQRQKLE---AQQGLRASQEAKQKVEKEAQARE 333
L + +E R + ER +E + +R++ E A+Q R QE Q E+E Q RE
Sbjct: 683 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ-AERELQERE 741
Query: 334 AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTK 393
L+ + Q Q LEEK +++ ++L+E E E+ E A + AL+ + +
Sbjct: 742 KALRLQ-KEQLQRELEEKKKKEEQQRLAERQLQE---EQEKKAKEAAGASKALNVTVDVQ 797
Query: 394 -----SQPMMPVSRPMGPVPNP 410
S M P P NP
Sbjct: 798 SPACTSYQMTPQGHRAPPKINP 819
Score = 31.2 bits (69), Expect = 2.0
Identities = 25/88 (28%), Positives = 46/88 (52%), Gaps = 9/88 (10%)
Query: 296 RVARENSDLQRQKLEAQQGLRASQ---EAKQKVEKEAQAREAKLQAECSRQTQL-----A 347
R E L+RQK+E + R + + ++++ K QARE Q + ++ Q+
Sbjct: 546 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Query: 348 LEEKAVLRKERDNLAKELEEKKREAEQL 375
++EK KE + LA+E +KK A+++
Sbjct: 606 IDEKTEKAKE-ERLAEEKAKKKAAAKKM 632
Score = 28.9 bits (63), Expect = 9.8
Identities = 50/211 (23%), Positives = 86/211 (40%), Gaps = 16/211 (7%)
Query: 160 MLNQKVKTLEVEIAKEKTICTKDKESVLLN----KRVAEEQLVECVKTRELQHQERQLAK 215
M +K K +E + A+ K KE L K+ A +++ E R+ + + R+L
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
Query: 216 EQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHM 275
Q ++ + L + K E + L + + R + E RR +
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE--RREQERR 708
Query: 276 PSLMSSKVEELA-RSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA 334
+ +LA + R + ER+ E +R+K Q + +E ++K +KE Q R A
Sbjct: 709 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 768
Query: 335 KLQAECSRQTQLALEEKAVLRKERDNLAKEL 365
+ RQ Q E+KA KE +K L
Sbjct: 769 E------RQLQEEQEKKA---KEAAGASKAL 790
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.9 bits (115), Expect = 9e-06
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 16/114 (14%)
Query: 274 HMPSLMSSKVEELARSLRA----------DIERVARENSDLQRQKLEAQQGLRASQEAKQ 323
H L K EE R +A + ER +E + +R++ E ++ R QE +Q
Sbjct: 656 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE-RQ 714
Query: 324 KVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRM 377
E+E + + +LQAE Q E + LR +++ L +ELEEKK++ EQ R+
Sbjct: 715 LAEQERRREQERLQAERELQ-----EREKALRLQKEQLQRELEEKKKKEEQQRL 763
Score = 47.0 bits (110), Expect = 3e-05
Identities = 41/129 (31%), Positives = 62/129 (48%), Gaps = 5/129 (3%)
Query: 261 LGSELASIRRACDHMPSLMSS-KVEELARSLR--ADIERVARENSDLQRQKLEAQQGLRA 317
L E A + A M + + K EE AR LR E R LQ++K E Q+ LR
Sbjct: 614 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673
Query: 318 SQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRM 377
+ EAK+ E+ Q R + + E R+ Q E++ R++ LA++ +++E Q
Sbjct: 674 AAEAKRLAEQREQERREQERREQERREQERREQER--REQERQLAEQERRREQERLQAER 731
Query: 378 ELAIRNSAL 386
EL R AL
Sbjct: 732 ELQEREKAL 740
Score = 39.3 bits (90), Expect = 0.007
Identities = 60/262 (22%), Positives = 111/262 (42%), Gaps = 26/262 (9%)
Query: 161 LNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAE-EQLVECVKTRELQHQE--RQLAKEQ 217
L ++ + +V A+E+ K+++ + ++ A+ ++ E K L ++ ++ A ++
Sbjct: 568 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 627
Query: 218 LQKVQALCLPLDKDKFEMDLRNL-WRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMP 276
+++V+A + K E + R L W + L E R
Sbjct: 628 MEEVEA------RRKQEEEARRLRWLQQ---EEEERRHQELLQKKKEEEQERLRKAAEAK 678
Query: 277 SLMSSKVEELARSLRADIERVARENSDLQRQKLE---AQQGLRASQEAKQKVEKEAQARE 333
L + +E R + ER +E + +R++ E A+Q R QE Q E+E Q RE
Sbjct: 679 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ-AERELQERE 737
Query: 334 AKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTK 393
L+ + Q Q LEEK +++ ++L+E E E+ E A + AL+ + +
Sbjct: 738 KALRLQ-KEQLQRELEEKKKKEEQQRLAERQLQE---EQEKKAKEAAGASKALNVTVDVQ 793
Query: 394 -----SQPMMPVSRPMGPVPNP 410
S M P P NP
Sbjct: 794 SPACTSYQMTPQGHRAPPKINP 815
Score = 36.2 bits (82), Expect = 0.061
Identities = 45/184 (24%), Positives = 76/184 (41%), Gaps = 24/184 (13%)
Query: 202 KTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPL 261
K +E Q E KE+ ++++ + K E D R R L+ + L
Sbjct: 531 KEKERQRLENLRRKEEAEQLR-------RQKVEEDKR---------RRLEEVKLKREERL 574
Query: 262 GSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEA 321
L + R + M ++E+ + E+ E ++ K +A EA
Sbjct: 575 RKVLQA-RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 633
Query: 322 KQKVEKEAQAREAKLQAECSRQTQLAL-----EEKAVLRK--ERDNLAKELEEKKREAEQ 374
++K E+EA+ Q E R+ Q L EE+ LRK E LA++ E+++RE E+
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
Query: 375 LRME 378
E
Sbjct: 694 REQE 697
Score = 28.9 bits (63), Expect = 9.8
Identities = 50/211 (23%), Positives = 86/211 (40%), Gaps = 16/211 (7%)
Query: 160 MLNQKVKTLEVEIAKEKTICTKDKESVLLN----KRVAEEQLVECVKTRELQHQERQLAK 215
M +K K +E + A+ K KE L K+ A +++ E R+ + + R+L
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
Query: 216 EQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHM 275
Q ++ + L + K E + L + + R + E RR +
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE--RREQERR 704
Query: 276 PSLMSSKVEELA-RSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA 334
+ +LA + R + ER+ E +R+K Q + +E ++K +KE Q R A
Sbjct: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 764
Query: 335 KLQAECSRQTQLALEEKAVLRKERDNLAKEL 365
+ RQ Q E+KA KE +K L
Sbjct: 765 E------RQLQEEQEKKA---KEAAGASKAL 786
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,074,286
Number of Sequences: 37866
Number of extensions: 674529
Number of successful extensions: 9755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 789
Number of HSP's that attempted gapping in prelim test: 5507
Number of HSP's gapped (non-prelim): 3463
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.