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Search of human proteins with 68161546
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo
sapiens]
(1312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 2674 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 2662 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 2563 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 2556 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1647 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1642 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1632 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1627 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1608 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1602 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1592 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1587 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1544 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1472 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 1390 0.0
gi|118600963 Nik related kinase [Homo sapiens] 408 e-113
gi|145275208 myosin IIIA [Homo sapiens] 310 8e-84
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 292 2e-78
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 292 2e-78
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 264 4e-70
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 262 2e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 257 4e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 257 4e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 256 8e-68
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 256 1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 253 8e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 249 9e-66
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 249 9e-66
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 243 7e-64
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 243 9e-64
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 2674 bits (6932), Expect = 0.0
Identities = 1312/1312 (100%), Positives = 1312/1312 (100%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600
Query: 601 PAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALN 660
PAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALN
Sbjct: 601 PAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALN 660
Query: 661 TSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRS 720
TSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRS
Sbjct: 661 TSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRS 720
Query: 721 DPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA 780
DPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA
Sbjct: 721 DPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA 780
Query: 781 DFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDT 840
DFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDT
Sbjct: 781 DFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDT 840
Query: 841 DSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPT 900
DSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPT
Sbjct: 841 DSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPT 900
Query: 901 ENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGT 960
ENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGT
Sbjct: 901 ENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGT 960
Query: 961 RLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGL 1020
RLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGL
Sbjct: 961 RLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGL 1020
Query: 1021 MLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPE 1080
MLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPE
Sbjct: 1021 MLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPE 1080
Query: 1081 VEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADL 1140
VEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADL
Sbjct: 1081 VEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADL 1140
Query: 1141 PHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPN 1200
PHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPN
Sbjct: 1141 PHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPN 1200
Query: 1201 TDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1260
TDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE
Sbjct: 1201 TDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1260
Query: 1261 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Sbjct: 1261 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 2662 bits (6901), Expect = 0.0
Identities = 1312/1332 (98%), Positives = 1312/1332 (98%), Gaps = 20/1332 (1%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 583 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640
QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 641 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
Query: 701 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
Query: 761 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 820
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 781 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840
Query: 821 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 880
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 841 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900
Query: 881 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 940
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 901 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960
Query: 941 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 961 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020
Query: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
Query: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140
Query: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200
Query: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260
Query: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320
Query: 1301 FMTLNRNCIMNW 1312
FMTLNRNCIMNW
Sbjct: 1321 FMTLNRNCIMNW 1332
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 2563 bits (6644), Expect = 0.0
Identities = 1275/1332 (95%), Positives = 1275/1332 (95%), Gaps = 57/1332 (4%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 583 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640
QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 641 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
Query: 701 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
Query: 761 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 820
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 744 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
Query: 821 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 880
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 804 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 863
Query: 881 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 940
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 864 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 923
Query: 941 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 924 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 983
Query: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 984 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1043
Query: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1044 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1103
Query: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1104 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1163
Query: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1164 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1223
Query: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1224 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1283
Query: 1301 FMTLNRNCIMNW 1312
FMTLNRNCIMNW
Sbjct: 1284 FMTLNRNCIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 2556 bits (6625), Expect = 0.0
Identities = 1275/1340 (95%), Positives = 1275/1340 (95%), Gaps = 65/1340 (4%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 583 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640
QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 641 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
Query: 701 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
Query: 761 LSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 812
LSPGNKAKPDDHRSRPGRPA DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES
Sbjct: 744 LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 803
Query: 813 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 872
SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP
Sbjct: 804 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 863
Query: 873 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 932
EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT
Sbjct: 864 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 923
Query: 933 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 992
MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR
Sbjct: 924 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 983
Query: 993 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1052
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL
Sbjct: 984 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1043
Query: 1053 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1112
ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI
Sbjct: 1044 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1103
Query: 1113 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1172
ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV
Sbjct: 1104 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1163
Query: 1173 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1232
DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG
Sbjct: 1164 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1223
Query: 1233 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1292
EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1224 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1283
Query: 1293 SGGSSQVYFMTLNRNCIMNW 1312
SGGSSQVYFMTLNRNCIMNW
Sbjct: 1284 SGGSSQVYFMTLNRNCIMNW 1303
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1647 bits (4266), Expect = 0.0
Identities = 896/1385 (64%), Positives = 1033/1385 (74%), Gaps = 135/1385 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQ---------EGP----HKSLQD 584
K + +P +P S ++TPPM RPV+PQ +GP +S+ +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
Query: 585 QPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWV 638
QPT+ L+ F + + S R + RQNSDPTSE P P P + +W+
Sbjct: 585 QPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWL 633
Query: 639 RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKP 698
R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 634 RQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ---------------- 673
Query: 699 PGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP--QA 741
P +SNPDLRR++P E S S P+S G P QA
Sbjct: 674 ----------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 723
Query: 742 GSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAP 794
GS ER RV +SK + SPVL K KP++ R +RP RPAD L +E ++E
Sbjct: 724 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETN 783
Query: 795 RPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTM 846
RP KK DYSSSSEE ESSE++EE+GE +G+ D P G + +V +
Sbjct: 784 RPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMV 843
Query: 847 VVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHS 898
H +E T + G GT++++ T E++ H+DSNG+ NLPD+VQ SHS
Sbjct: 844 GTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHS 901
Query: 899 P----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS----- 948
P TE S S++ SG G + K+SFT FVD +YQ + +
Sbjct: 902 PAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEE 958
Query: 949 IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAAL 1007
AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAAL
Sbjct: 959 SSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAAL 1018
Query: 1008 WGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYL 1067
WGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYL
Sbjct: 1019 WGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYL 1078
Query: 1068 SWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP 1127
SWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKP
Sbjct: 1079 SWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKP 1138
Query: 1128 YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ 1187
YHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ
Sbjct: 1139 YHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQ 1198
Query: 1188 SQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIM 1247
ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIM
Sbjct: 1199 GNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIM 1258
Query: 1248 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRN 1307
GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN
Sbjct: 1259 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRN 1318
Query: 1308 CIMNW 1312
+MNW
Sbjct: 1319 SMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1642 bits (4252), Expect = 0.0
Identities = 895/1393 (64%), Positives = 1033/1393 (74%), Gaps = 143/1393 (10%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQ---------EGP----HKSLQD 584
K + +P +P S ++TPPM RPV+PQ +GP +S+ +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
Query: 585 QPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWV 638
QPT+ L+ F + + S R + RQNSDPTSE P P P + +W+
Sbjct: 585 QPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWL 633
Query: 639 RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKP 698
R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 634 RQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ---------------- 673
Query: 699 PGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP--QA 741
P +SNPDLRR++P E S S P+S G P QA
Sbjct: 674 ----------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 723
Query: 742 GSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL------------LK 786
GS ER RV +SK + SPVL K KP++ R +RP RPA + L+
Sbjct: 724 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELR 783
Query: 787 ERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDG 838
E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 784 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 843
Query: 839 DTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLP 890
+ +V + H +E T + G GT++++ T E++ H+DSNG+ NLP
Sbjct: 844 EQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLP 901
Query: 891 DVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGS 945
D+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ +
Sbjct: 902 DLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPT 958
Query: 946 GDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFN 999
+ AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFN
Sbjct: 959 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN 1018
Query: 1000 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKR 1059
SEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+
Sbjct: 1019 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK 1078
Query: 1060 NKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVE 1119
NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE
Sbjct: 1079 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE 1138
Query: 1120 VYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYD 1179
+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYD
Sbjct: 1139 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD 1198
Query: 1180 IYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVA 1239
IYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVA
Sbjct: 1199 IYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVA 1258
Query: 1240 YICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1299
YI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV
Sbjct: 1259 YIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1318
Query: 1300 YFMTLNRNCIMNW 1312
+FMTLNRN +MNW
Sbjct: 1319 FFMTLNRNSMMNW 1331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1632 bits (4226), Expect = 0.0
Identities = 896/1414 (63%), Positives = 1033/1414 (73%), Gaps = 164/1414 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQ---------EGP----HKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGA 615
RPV+PQ +GP +S+ +QPT+ L+ F + + S R
Sbjct: 585 LRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN----------VTSHRVE 634
Query: 616 VIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRP 669
+ RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL + G+
Sbjct: 635 MPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGS 693
Query: 670 AQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER--- 726
A PR S P +SNPDLRR++P E
Sbjct: 694 ALG----PRLGSQ--------------------------PIRASNPDLRRTEPILESPLQ 723
Query: 727 -------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDD 771
S S P+S G P QAGS ER RV +SK + SPVL K KP++
Sbjct: 724 RTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEE 783
Query: 772 HR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPA 825
R +RP RPAD L +E ++E RP KK DYSSSSEE ESSE++EE+GE
Sbjct: 784 SRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETH 843
Query: 826 EGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTP 872
+G+ D P G + +V + H +E T + G GT++++ T
Sbjct: 844 DGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETS 901
Query: 873 EEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVK 924
E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG G
Sbjct: 902 GEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG--- 958
Query: 925 APGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVN 978
+ K+SFT FVD +YQ + + AL E R +Q + + RK SVVNVN
Sbjct: 959 SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVN 1018
Query: 979 PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRR 1038
PTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RR
Sbjct: 1019 PTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRR 1078
Query: 1039 RFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGH 1098
RFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC H
Sbjct: 1079 RFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIH 1138
Query: 1099 YRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLK 1158
Y+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLK
Sbjct: 1139 YKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLK 1198
Query: 1159 VIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVN 1218
VI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVN
Sbjct: 1199 VIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVN 1258
Query: 1219 TYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF 1278
TYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
Sbjct: 1259 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF 1318
Query: 1279 LCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
LCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1319 LCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1627 bits (4212), Expect = 0.0
Identities = 895/1422 (62%), Positives = 1033/1422 (72%), Gaps = 172/1422 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQ---------EGP----HKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGA 615
RPV+PQ +GP +S+ +QPT+ L+ F + + S R
Sbjct: 585 LRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN----------VTSHRVE 634
Query: 616 VIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRP 669
+ RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL + G+
Sbjct: 635 MPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGS 693
Query: 670 AQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER--- 726
A PR S P +SNPDLRR++P E
Sbjct: 694 ALG----PRLGSQ--------------------------PIRASNPDLRRTEPILESPLQ 723
Query: 727 -------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDD 771
S S P+S G P QAGS ER RV +SK + SPVL K KP++
Sbjct: 724 RTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEE 783
Query: 772 HR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDE 817
R +RP RPA + L+E ++E RP KK DYSSSSEE ESSE++E
Sbjct: 784 SRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 843
Query: 818 EEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----G 864
E+GE +G+ D P G + +V + H +E T + G G
Sbjct: 844 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREG 901
Query: 865 TMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGD 916
T++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 902 TLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGT 961
Query: 917 YQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVR 970
G + K+SFT FVD +YQ + + AL E R +Q + + R
Sbjct: 962 EYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEAR 1018
Query: 971 KGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1030
K SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK
Sbjct: 1019 KISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1078
Query: 1031 VYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTV 1090
VY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TV
Sbjct: 1079 VYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITV 1138
Query: 1091 GDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLT 1150
GD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLT
Sbjct: 1139 GDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLT 1198
Query: 1151 VEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCY 1210
VEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CY
Sbjct: 1199 VEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCY 1258
Query: 1211 EDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMH 1270
EDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMH
Sbjct: 1259 EDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMH 1318
Query: 1271 KRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
KRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1319 KRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1608 bits (4163), Expect = 0.0
Identities = 877/1369 (64%), Positives = 1004/1369 (73%), Gaps = 158/1369 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+E+ + Q
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-------- 517
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600
GP SQ S+ +QPT+ L+ F + +
Sbjct: 518 ----------------GPALTASQ----------------SVHEQPTKGLSGFQEALN-- 543
Query: 601 PAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSS 654
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+S
Sbjct: 544 --------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 594
Query: 655 IATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSN 714
I+ AL + G+ A PR S P +SN
Sbjct: 595 ISPALARKNSPGNGSALG----PRLGSQ--------------------------PIRASN 624
Query: 715 PDLRRSDPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDS 757
PDLRR++P E S S P+S G P QAGS ER RV +SK +
Sbjct: 625 PDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEG 684
Query: 758 SPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEV 810
SPVL K KP++ R +RP RPAD L +E ++E RP KK DYSSSSEE
Sbjct: 685 SPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEES 744
Query: 811 ESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYG 862
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 745 ESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFS 802
Query: 863 G-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPS 910
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S
Sbjct: 803 GSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHS 862
Query: 911 KD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQ 964
++ SG G + K+SFT FVD +YQ + + AL E R +Q
Sbjct: 863 QEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQ 919
Query: 965 LQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1023
+ + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL
Sbjct: 920 AKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 979
Query: 1024 DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEK 1083
DRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEK
Sbjct: 980 DRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEK 1039
Query: 1084 KQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR 1143
KQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+
Sbjct: 1040 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK 1099
Query: 1144 PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDG 1203
PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDG
Sbjct: 1100 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG 1159
Query: 1204 MEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGH 1263
MEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGH
Sbjct: 1160 MEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGH 1219
Query: 1264 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1220 LDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1602 bits (4149), Expect = 0.0
Identities = 876/1377 (63%), Positives = 1004/1377 (72%), Gaps = 166/1377 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+E+ + Q
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-------- 517
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPD 600
GP SQ S+ +QPT+ L+ F + +
Sbjct: 518 ----------------GPALTASQ----------------SVHEQPTKGLSGFQEALN-- 543
Query: 601 PAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSS 654
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+S
Sbjct: 544 --------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 594
Query: 655 IATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSN 714
I+ AL + G+ A PR S P +SN
Sbjct: 595 ISPALARKNSPGNGSALG----PRLGSQ--------------------------PIRASN 624
Query: 715 PDLRRSDPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDS 757
PDLRR++P E S S P+S G P QAGS ER RV +SK +
Sbjct: 625 PDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEG 684
Query: 758 SPVLS-PGNKAKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMD 802
SPVL K KP++ R +RP RPA + L+E ++E RP KK D
Sbjct: 685 SPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTD 744
Query: 803 YSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEI 854
YSSSSEE ESSE++EE+GE +G+ D P G + +V + H +E
Sbjct: 745 YSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE-- 802
Query: 855 TGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TEN 902
T + G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE
Sbjct: 803 TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEG 862
Query: 903 SKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVG 956
S S++ SG G + K+SFT FVD +YQ + + AL
Sbjct: 863 LGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFT 919
Query: 957 GEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVG 1015
E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVG
Sbjct: 920 SELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVG 979
Query: 1016 TENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKIL 1075
TENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+IL
Sbjct: 980 TENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRIL 1039
Query: 1076 HNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK 1135
HNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFK
Sbjct: 1040 HNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFK 1099
Query: 1136 SFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAI 1195
SFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI
Sbjct: 1100 SFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAI 1159
Query: 1196 IFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIE 1255
+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIE
Sbjct: 1160 VILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIE 1219
Query: 1256 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1220 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1592 bits (4123), Expect = 0.0
Identities = 877/1398 (62%), Positives = 1004/1398 (71%), Gaps = 187/1398 (13%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 571
+P++KPAWA+E+ + Q GP SQ
Sbjct: 526 SPSEKPAWAKEIPHLVAVKSQ------------------------GPALTASQ------- 554
Query: 572 VEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPS 631
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P
Sbjct: 555 ---------SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PL 594
Query: 632 P------NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQI 685
P + +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 595 PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--- 647
Query: 686 YLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH 735
P +SNPDLRR++P E S S P+S
Sbjct: 648 -----------------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQ 684
Query: 736 -----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL 785
G P QAGS ER RV +SK + SPVL K KP++ R +RP RPAD L
Sbjct: 685 PSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTAL 744
Query: 786 ----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----G 833
+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 745 AKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTG 804
Query: 834 GRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT- 887
+ +V + H +E T + G GT++++ T E++ H+DSNG+
Sbjct: 805 APGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAG 862
Query: 888 --NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIY 940
NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD +Y
Sbjct: 863 HINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVY 919
Query: 941 QPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKY 994
Q + + AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKY
Sbjct: 920 QTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKY 979
Query: 995 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLIT 1054
KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+T
Sbjct: 980 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVT 1039
Query: 1055 ISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIAL 1114
ISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIAL
Sbjct: 1040 ISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIAL 1099
Query: 1115 KSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDS 1174
K++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDS
Sbjct: 1100 KNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDS 1159
Query: 1175 GNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEM 1234
GNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEM
Sbjct: 1160 GNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEM 1219
Query: 1235 PTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1294
PTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG
Sbjct: 1220 PTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1279
Query: 1295 GSSQVYFMTLNRNCIMNW 1312
GSSQV+FMTLNRN +MNW
Sbjct: 1280 GSSQVFFMTLNRNSMMNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1587 bits (4109), Expect = 0.0
Identities = 876/1406 (62%), Positives = 1004/1406 (71%), Gaps = 195/1406 (13%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 571
+P++KPAWA+E+ + Q GP SQ
Sbjct: 526 SPSEKPAWAKEIPHLVAVKSQ------------------------GPALTASQ------- 554
Query: 572 VEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPS 631
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P
Sbjct: 555 ---------SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PL 594
Query: 632 P------NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQI 685
P + +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 595 PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--- 647
Query: 686 YLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH 735
P +SNPDLRR++P E S S P+S
Sbjct: 648 -----------------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQ 684
Query: 736 -----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL- 784
G P QAGS ER RV +SK + SPVL K KP++ R +RP RPA +
Sbjct: 685 PSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKA 744
Query: 785 -----------LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RD 830
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D
Sbjct: 745 IDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSD 804
Query: 831 TP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLH 880
P G + +V + H +E T + G GT++++ T E++ H
Sbjct: 805 IPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGH 862
Query: 881 ADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFT 932
+DSNG+ NLPD+VQ SHSP TE S S++ SG G + K+SFT
Sbjct: 863 SDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFT 919
Query: 933 MFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHS 986
FVD +YQ + + AL E R +Q + + RK SVVNVNPTN R HS
Sbjct: 920 PFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHS 979
Query: 987 ETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVL 1046
+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVL
Sbjct: 980 DTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVL 1039
Query: 1047 EGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYER 1106
EGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYER
Sbjct: 1040 EGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYER 1099
Query: 1107 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAG 1166
IKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS G
Sbjct: 1100 IKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTG 1159
Query: 1167 FHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKD 1226
FH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KD
Sbjct: 1160 FHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKD 1219
Query: 1227 VVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1286
VVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1220 VVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1279
Query: 1287 FFASVRSGGSSQVYFMTLNRNCIMNW 1312
FFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1280 FFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1544 bits (3997), Expect = 0.0
Identities = 866/1392 (62%), Positives = 985/1392 (70%), Gaps = 152/1392 (10%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRR-------LEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
+ QE+EQ+RR LE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
Query: 552 PQASPGPPGPLSQT--PPMQRPVEPQ-EGPHKSLQDQPTRNLAAFPASHDPDPA-----I 603
P S S++ P +QRP EPQ + H + ++ + DP P +
Sbjct: 597 PSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHL 656
Query: 604 PAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKVPQRTSSIATALNTS 662
+ P +R V+ Q+SD SE P P+ AW R D+ E PP+VP RT+S + L+
Sbjct: 657 RSQDPCPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRVPVRTTSRSPVLSRR 714
Query: 663 GA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLR 718
+ G + +QA + R ++S L R E+ P+P + G N+ S P
Sbjct: 715 DSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSGSQPG-- 769
Query: 719 RSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--R 775
S PG Q+GS ER RV SSK + SP N K P+D + R
Sbjct: 770 -SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFR 813
Query: 776 PGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEG 827
P +PA V L KE E RPP K DYSSSSEE E +D E+EG G
Sbjct: 814 PLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSG 873
Query: 828 SRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADS 883
DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 874 PEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--------- 924
Query: 884 NGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG 943
S L K SSFT F+D + Q
Sbjct: 925 -----------------------------------SSTLQKHKSSSSFTPFIDPRLLQIS 949
Query: 944 GSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000
S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNS
Sbjct: 950 PSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 1008
Query: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
EILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++
Sbjct: 1009 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 1068
Query: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEV
Sbjct: 1069 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1128
Query: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180
YAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDI
Sbjct: 1129 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1188
Query: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240
Y+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAY
Sbjct: 1189 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1248
Query: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300
I SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1249 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1308
Query: 1301 FMTLNRNCIMNW 1312
FMTL R +++W
Sbjct: 1309 FMTLGRTSLLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1472 bits (3812), Expect = 0.0
Identities = 826/1339 (61%), Positives = 941/1339 (70%), Gaps = 154/1339 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER----LQRQLQQEHAY 475
+ QE+EQ+RR + + RR EE + +E+E +R+ EE+R+ ER ++RQL++E +
Sbjct: 421 RQQEREQRRR--EQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRH 478
Query: 476 LKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
L+ LQQQ Q+Q LL R+P + + P +
Sbjct: 479 LEVLQQQLLQEQAM------LLHDHRRPHPQHSQQPPPPQQE------------------ 514
Query: 536 PLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPA 595
+SKP PEP + P R E ++ K+ P
Sbjct: 515 ---RSKPSFHAPEPK------------AHYEPADRAREVEDRFRKTNHSSPEAQSKQTGR 559
Query: 596 SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSI 655
+P P P+ S+ S G S +P A RP A P+VP RT+S
Sbjct: 560 VLEP----PVPS------------RSESFSNGNSESVHP-ALQRP---AEPQVPVRTTSR 599
Query: 656 ATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNA 711
+ L+ + G + +QA + R ++S L R E+ P+P + G N+
Sbjct: 600 SPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNS 656
Query: 712 SSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PD 770
S P S PG Q+GS ER RV SSK + SP N K P+
Sbjct: 657 GSQPG---SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPE 698
Query: 771 DHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEG 820
D + RP +PA V L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 699 DKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEG 758
Query: 821 EGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEER 876
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 759 ADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA-- 816
Query: 877 NLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVD 936
S L K SSFT F+D
Sbjct: 817 ------------------------------------------SSTLQKHKSSSSFTPFID 834
Query: 937 LGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRK 993
+ Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRK
Sbjct: 835 PRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRK 893
Query: 994 YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI 1053
YKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+
Sbjct: 894 YKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLV 953
Query: 1054 TISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIA 1113
TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIA
Sbjct: 954 TISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIA 1013
Query: 1114 LKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVD 1173
LKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVD
Sbjct: 1014 LKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVD 1073
Query: 1174 SGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGE 1233
SG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGE
Sbjct: 1074 SGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGE 1133
Query: 1234 MPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1293
MPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS
Sbjct: 1134 MPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1193
Query: 1294 GGSSQVYFMTLNRNCIMNW 1312
GGSSQVYFMTL R +++W
Sbjct: 1194 GGSSQVYFMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 1390 bits (3599), Expect = 0.0
Identities = 796/1346 (59%), Positives = 909/1346 (67%), Gaps = 214/1346 (15%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL ER++R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLL----------------------AERQKR 398
Query: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Q+KEQ+RRLE+ Q RE+E +R+Q EQR+ E Q+E L+ L
Sbjct: 399 IEQQKEQRRRLEEQQ-----------RREREARRQQEREQRRRE------QEEKRRLEEL 441
Query: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
++++++++ ++ R EE+ R+ ++Q
Sbjct: 442 ERRRKEEEERR------------------------------RAEEEKRRVEREQEY---- 467
Query: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDP 599
++R +E ++ + LQ Q + A H
Sbjct: 468 ----------------------------IRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRR 499
Query: 600 DPAIPAPTATPSARGAVIRQNSDPTSEGPGPS---PNPPAWVRPDNEAPPKVPQRTSSIA 656
P P + +Q P E PS P P A P + A +VP RT+S +
Sbjct: 500 ----PHPQHS--------QQPPPPQQERSKPSFHAPEPKAHYEPADRAR-EVPVRTTSRS 546
Query: 657 TALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS 712
L+ + G + +QA + R ++S L R E+ P+P + G N+
Sbjct: 547 PVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSG 603
Query: 713 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDD 771
S P S PG Q+GS ER RV SSK + SP N K P+D
Sbjct: 604 SQPG---SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPED 645
Query: 772 HRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGE 821
+ RP +PA V L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 646 KKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGA 705
Query: 822 GGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN 877
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 706 DESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--- 762
Query: 878 LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDL 937
S L K SSFT F+D
Sbjct: 763 -----------------------------------------SSTLQKHKSSSSFTPFIDP 781
Query: 938 GIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKY 994
+ Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKY
Sbjct: 782 RLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 840
Query: 995 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLIT 1054
KKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+T
Sbjct: 841 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 900
Query: 1055 ISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIAL 1114
ISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIAL
Sbjct: 901 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 960
Query: 1115 KSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDS 1174
KSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDS
Sbjct: 961 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1020
Query: 1175 GNSYDIYIPVH--------IQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKD 1226
G+ YDIY+P H IQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KD
Sbjct: 1021 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1080
Query: 1227 VVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1286
VVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1081 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1140
Query: 1287 FFASVRSGGSSQVYFMTLNRNCIMNW 1312
FFASVRSGGSSQVYFMTL R +++W
Sbjct: 1141 FFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 408 bits (1048), Expect = e-113
Identities = 259/676 (38%), Positives = 366/676 (54%), Gaps = 81/676 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M P R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 61 ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156
QLW+VME C AGSVTD+V+ T +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R P +KS WS+KF +F++ C IK +L
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327
RP + +L+ PF+RD ER V L H I + R+K+G E+EE + +Y+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 328 EEDDS--------------------HGEEGEP-----------SSIMNVPGESTLRREFL 356
S HGE +P ++ + G + R F+
Sbjct: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAA---RVFM 417
Query: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
LQ + S + LK Q Q Q+ Q + Q Q + + K + +++ R R
Sbjct: 418 PLQALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRR 473
Query: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
R L + Q R + ++ + ++Q + Q + + L++ + + Q Q+ ++
Sbjct: 474 AARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQG 533
Query: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
++ +QQQ+ Q+ +Q+ +Q ++ + + PA A E E R+N Q P
Sbjct: 534 QAPEQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLP 590
Query: 537 LAKSK-----PGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLA 591
L P + IP P +Q ++ P G ++L + +R+L
Sbjct: 591 LLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPP--QAIGSVQALIEGLSRDLL 648
Query: 592 AFPASHDPDPAIPAPT 607
P S++ P P T
Sbjct: 649 RAPNSNNSKPLGPLQT 664
Score = 282 bits (721), Expect = 2e-75
Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)
Query: 792 EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 848
EAP P+ + D S + + S EE G G +R G + D ++
Sbjct: 986 EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
Query: 849 HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 906
H + + G G V RT EE L L+ + N T+ P + +P+ E + +
Sbjct: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
Query: 907 SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 953
+ S S AP S + Q G S D+ +A
Sbjct: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
Query: 954 LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1013
++ + + ++ S VNVNP + P I Y+K F SEI C +LWGVNLL
Sbjct: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
Query: 1014 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1073
+GT + L L+DRSG+ + LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
Query: 1074 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1125
IL+NDPE +++Q + + GC H+ V+++E ++ IALKSS+ +YAWAP
Sbjct: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
Query: 1126 K---------------------------------------PYHKF---------MAFKSF 1137
K P ++F + K F
Sbjct: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
Query: 1138 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1197
L H+P+ VDL + +RLK+ + S+ G+H +D +S D+ +P + I P II
Sbjct: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
Query: 1198 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1257
LP+ G+ M+L + E + V ++ K ++ W ++P+S+A+ C+ + GWG+KAIE+R
Sbjct: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
Query: 1258 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1306
S+++ L+ + ++L+FLC R DK+FF S S+VYFMTL +
Sbjct: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 42.7 bits (99), Expect = 0.002
Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)
Query: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399
L R+ LR N +NS+ L Q L Q +Q R+ ++ + L +R+
Sbjct: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
Query: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459
++ + ++ E + + + +QRR ED+ + EEE RQ ++++E + +E
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
Query: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511
S + + Q++ Y+ + ++++ Q++ +P ++ +H +
Sbjct: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
Query: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553
A KP R+ + R N ++ SP+ + S+ P I Q
Sbjct: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 310 bits (793), Expect = 8e-84
Identities = 153/273 (56%), Positives = 189/273 (69%), Gaps = 4/273 (1%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREI 137
N+ +YG + KK N D+LWLV+E C GSVTDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WSLGITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
WS +F DFI CL K Y RP +LL+ FI
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 264 bits (675), Expect = 4e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
Query: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 262 bits (669), Expect = 2e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
Query: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
Query: 369 LKQQQQLQQQQQRDPEAH 386
Q + +++ E H
Sbjct: 332 TFGQVKFDPPLRKETEPH 349
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 4e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 4e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 256 bits (655), Expect = 8e-68
Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++DIWSLGITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
SK F +F++ CL K RP ++LLK FI + +L D R KR + E
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
Query: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346
E S + + D E+GE I P
Sbjct: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 256 bits (653), Expect = 1e-67
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
Query: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
Query: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
Query: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
Query: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
+ + I R + ++E E E + E+E DSH
Sbjct: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 253 bits (646), Expect = 8e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
Query: 355 FLRLQQENKSNSEALKQQQQLQQ 377
F L+Q++++N+ + ++L++
Sbjct: 361 FAELKQQDENNASRNQAIEELEK 383
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 249 bits (637), Expect = 9e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 300 HDDSSSEDSDAETDGQASGGSDS 322
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 249 bits (637), Expect = 9e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 254
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 311
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 312 HDDSSSEDSDAETDGQASGGSDS 334
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 243 bits (621), Expect = 7e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
E+ E E Y + S G+ G
Sbjct: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 243 bits (620), Expect = 9e-64
Identities = 181/610 (29%), Positives = 298/610 (48%), Gaps = 50/610 (8%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
NI AF ++ LW+++EFC G+V D V L E I +C++ L
Sbjct: 89 P-NIVKLLDAFYY------ENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
Query: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
L +LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
Query: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
V+ C+ + D YDY++D+WSLGIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTE--RQVRIQLKDHID---RSRKK 312
WS F DF+ CL K +R T QLL+ PF+ + R++ + K + K+
Sbjct: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
Query: 313 RGEKEETEYEY----SGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEA 368
E+EETE S D S E N ++ + R E+K NS+
Sbjct: 321 EDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKI 380
Query: 369 LKQQQQLQQQQQ--RDPEAHIKHL-------LHQRQRRIEEQKEERRRVEEQQRREREQR 419
L ++ + ++ D HI LH R I+E + E+R E +Q
Sbjct: 381 LNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQE 440
Query: 420 KL--------QEKEQQRRLE-DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQL- 469
+ +E LE +++ + EE + E++Q ++ K ++ + + + + +
Sbjct: 441 TVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVD 500
Query: 470 ---QQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP----LYHYGRGMNPADKPAWARE 522
Q+ ++Q + L K+ Q+ L D K + + + + A++
Sbjct: 501 LVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQK 560
Query: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPI--PQASPGPPGPLSQTPPMQRPVEPQEGPHK 580
V+E + + Q N + G P+ P+A P+ + M E +EG +K
Sbjct: 561 VDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMN---EIEEGKNK 617
Query: 581 SLQDQPTRNL 590
+ N+
Sbjct: 618 EQAINSSENI 627
Score = 60.8 bits (146), Expect = 8e-09
Identities = 53/224 (23%), Positives = 111/224 (49%), Gaps = 26/224 (11%)
Query: 288 FIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNV- 345
F ++ ++++ Q +++++ +K+ E+ E E+ +E GE E E S N+
Sbjct: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
Query: 346 ------------PGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
LR+E ++ ++E + S+ ++Q+ +Q+QQQ + + +K ++ Q
Sbjct: 923 KNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQ-ELDGSLKKIIQQ 981
Query: 394 R-------QRRIEEQKEERRRVEEQQRREREQRKLQEKEQ--QRRLEDMQALRREEERRQ 444
+ +R K++ R E E E+R LQEK Q +++L+D ++R + ++
Sbjct: 982 QKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKR 1041
Query: 445 AEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQL 488
E+E E + Q QR E L+ + QE A L +Q+ + + ++
Sbjct: 1042 HEKETE--QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRM 1083
Score = 49.3 bits (116), Expect = 2e-05
Identities = 68/300 (22%), Positives = 122/300 (40%), Gaps = 61/300 (20%)
Query: 292 QPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTL 351
Q T RQ K + ++RK + E S + DS EE + L
Sbjct: 783 QETRRQ-----KKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFL 837
Query: 352 RREFLRLQQENKSNSEALKQQ-----QQLQQQQQRDPEAHIKHLLHQRQRRIEE-QKEER 405
++E R QQ+ S + ++Q +Q ++R + I++L Q+++ IE ++E
Sbjct: 838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHT 897
Query: 406 RRVEEQQRR-----EREQRKLQEKEQQRRLEDMQAL-------------RREEERRQAER 447
R+ ++ +R E+E K Q + R+ E + + RR+EE Q++
Sbjct: 898 NRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQH 957
Query: 448 EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQ------------------------Q 483
QE + Q ++Q L++ +QQ+ A L +++++ Q
Sbjct: 958 AQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQ 1017
Query: 484 QQQQLQKQ--------QQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
++ QL KQ Q+ QLL K R + R+ +ER R+ K Q S
Sbjct: 1018 EKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRS 1077
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 21/160 (13%)
Query: 358 LQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQQ 412
LQ++++ + LK Q +Q+ Q + E + + QR IEE Q +ER R+ + Q
Sbjct: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Query: 413 RREREQRKLQEKEQQR----------RLEDMQALRREEERRQAER---EQEYKRKQLEEQ 459
R E + R K+ R R + Q +EE+R++ ER Q+++ + + Q
Sbjct: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQ 1135
Query: 460 RQSE---RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Q E R QLQ E +L + Q+ ++L ++ Q+L
Sbjct: 1136 LQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/91 (25%), Positives = 47/91 (51%), Gaps = 15/91 (16%)
Query: 359 QQENKSNSEALKQQQQLQQQQ---QRDPEAHIK----------HLL--HQRQRRIEEQKE 403
Q+E + +E + Q Q+ + Q Q EA+++ HLL H+ Q+ E +E
Sbjct: 1111 QEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEE 1170
Query: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQ 434
+ ++E + + R ++K E+E R+L++ +
Sbjct: 1171 HSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,355,410
Number of Sequences: 37866
Number of extensions: 3752771
Number of successful extensions: 87955
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1694
Number of HSP's successfully gapped in prelim test: 2600
Number of HSP's that attempted gapping in prelim test: 22124
Number of HSP's gapped (non-prelim): 26804
length of query: 1312
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1198
effective length of database: 13,930,794
effective search space: 16689091212
effective search space used: 16689091212
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.