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Search of human proteins with 66932999
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 1309 0.0
gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 446 e-125
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 227 3e-59
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 227 3e-59
gi|4505001 LIM domain kinase 1 [Homo sapiens] 226 6e-59
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens] 224 1e-58
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 114 2e-25
gi|4503787 fyn-related kinase [Homo sapiens] 114 3e-25
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 112 8e-25
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 112 1e-24
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 111 2e-24
gi|38327632 discoidin domain receptor family, member 1 isoform b... 110 3e-24
gi|83977450 discoidin domain receptor family, member 1 isoform a... 110 3e-24
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 110 3e-24
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 108 1e-23
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 108 1e-23
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 108 1e-23
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 108 1e-23
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 108 1e-23
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 108 1e-23
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 107 3e-23
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 107 3e-23
gi|83977452 discoidin domain receptor family, member 1 isoform c... 107 3e-23
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 107 3e-23
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 107 3e-23
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 107 3e-23
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 106 7e-23
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 106 7e-23
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 106 7e-23
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 106 7e-23
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 1309 bits (3387), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA 60
MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA
Sbjct: 1 MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA 60
Query: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV 120
EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV
Sbjct: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV 120
Query: 121 HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN 180
HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN
Sbjct: 121 HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN 180
Query: 181 CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV 240
CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV
Sbjct: 181 CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV 240
Query: 241 FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST 300
FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST
Sbjct: 241 FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST 300
Query: 301 RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF 360
RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF
Sbjct: 301 RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF 360
Query: 361 LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT 420
LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT
Sbjct: 361 LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT 420
Query: 421 TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP 480
TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP
Sbjct: 421 TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP 480
Query: 481 GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS 540
GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS
Sbjct: 481 GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS 540
Query: 541 LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE 600
LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE
Sbjct: 541 LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE 600
Query: 601 AGSLLCHRGHHAKPPTPSLQLPGARS 626
AGSLLCHRGHHAKPPTPSLQLPGARS
Sbjct: 601 AGSLLCHRGHHAKPPTPSLQLPGARS 626
>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
Length = 571
Score = 446 bits (1146), Expect = e-125
Identities = 274/524 (52%), Positives = 316/524 (60%), Gaps = 71/524 (13%)
Query: 21 EGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSG 80
EG G G GR PSSYRAL SA S L R+DDF C EKIG+GFFSEV+KVRHR SG
Sbjct: 23 EGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTC-EKIGSGFFSEVFKVRHRASG 81
Query: 81 QVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQL 140
QVM LKMN L SNR N L+EVQLMNRL HPNILRFMGVCVHQGQLHALTEY+N G LEQL
Sbjct: 82 QVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQL 141
Query: 141 LSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA 200
L S L W VR+ LA DIA GL YLH KG+FHRDLTSKNCL++R++ G++AVV DFGLA
Sbjct: 142 LDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLA 201
Query: 201 EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDY 260
EKIP G+ K LAVVGSP+WMAPEVLR E Y+EKADVF++GI+LCE+IAR+ ADPDY
Sbjct: 202 EKIPDVSMGSEK--LAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDY 259
Query: 261 LPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPE 320
LPRTE+FGLD AF+ +VG DCP FL L +CCN++P R F EI + LE IL +L E
Sbjct: 260 LPRTENFGLDYDAFQHMVG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQE 318
Query: 321 P--------APLTRTALTHNQGSVARGGPSATLPR--PDPR----LSRSRSDLFLPPSPE 366
P R L G +P P PR LSRS+SD+F P
Sbjct: 319 EEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPR 378
Query: 367 S---------PPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLV--PPSPFPSTQ 415
+ P + +VNPFS R+DL GGKIK D PSK V+ LV +P P T
Sbjct: 379 TVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGT- 437
Query: 416 LPLVTTPETLVQPGTPARRCRSLPSSPELPR--------RMETALPGPGP---------- 457
+PL E L P RR RSLP SPE R E+ GP P
Sbjct: 438 MPLADWQEPL---APPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVK 494
Query: 458 ----------PAVGPSAEEKMECE--------GSSPEPEPPGPA 483
PA A E M+C GS P+ P PA
Sbjct: 495 EIPPFRASALPAA--QAHEAMDCSILQEENGFGSRPQGTSPCPA 536
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 227 bits (578), Expect = 3e-59
Identities = 133/317 (41%), Positives = 176/317 (55%), Gaps = 25/317 (7%)
Query: 37 RPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNR 94
R S R S + R D E +G GFF + KV H+ +G+VMV+K + +
Sbjct: 290 RSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ 349
Query: 95 GNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLH 154
L EV++M L HPN+L+F+GV +L+ LTEY+ GGTL+ L S +P W ++
Sbjct: 350 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVR 409
Query: 155 LALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGA---- 210
A IA G+ YLHS + HRDL S NCL++ + T VV DFGL+ I R+ A
Sbjct: 410 FAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEK 466
Query: 211 ------------RKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
RK+ VVG+PYWMAPE+L G+ YDE D+F+FGIVLCE+I +V ADP
Sbjct: 467 ATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADP 526
Query: 259 DYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWI--- 314
D LPRT DFGL+V F V DCP F LA CC LEP +R F+++ E +
Sbjct: 527 DCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLY 586
Query: 315 LEQLPEPAPLTRTALTH 331
L +L P P L H
Sbjct: 587 LGELGIPLPAELEELDH 603
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 227 bits (578), Expect = 3e-59
Identities = 133/317 (41%), Positives = 176/317 (55%), Gaps = 25/317 (7%)
Query: 37 RPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNR 94
R S R S + R D E +G GFF + KV H+ +G+VMV+K + +
Sbjct: 311 RSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ 370
Query: 95 GNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLH 154
L EV++M L HPN+L+F+GV +L+ LTEY+ GGTL+ L S +P W ++
Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVR 430
Query: 155 LALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGA---- 210
A IA G+ YLHS + HRDL S NCL++ + T VV DFGL+ I R+ A
Sbjct: 431 FAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEK 487
Query: 211 ------------RKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
RK+ VVG+PYWMAPE+L G+ YDE D+F+FGIVLCE+I +V ADP
Sbjct: 488 ATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADP 547
Query: 259 DYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWI--- 314
D LPRT DFGL+V F V DCP F LA CC LEP +R F+++ E +
Sbjct: 548 DCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLY 607
Query: 315 LEQLPEPAPLTRTALTH 331
L +L P P L H
Sbjct: 608 LGELGIPLPAELEELDH 624
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 226 bits (575), Expect = 6e-59
Identities = 133/319 (41%), Positives = 178/319 (55%), Gaps = 22/319 (6%)
Query: 24 PGPGGTGGGPGR----GRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQS 79
PG G G + GR S R + + R D E +G G F + KV HR++
Sbjct: 303 PGAGSLGSPASQRKDLGRSESLRVV-CRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRET 361
Query: 80 GQVMVLK-MNKLPSNRGNT-LREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTL 137
G+VMV+K + + T L+EV++M L HPN+L+F+GV +L+ +TEY+ GGTL
Sbjct: 362 GEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTL 421
Query: 138 EQLLSSPEP-LSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGD 196
++ S + W R+ A DIA G+ YLHS + HRDL S NCLVR VV D
Sbjct: 422 RGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKN---VVVAD 478
Query: 197 FGLA----------EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIV 246
FGLA E + ++ RK+ VVG+PYWMAPE++ G YDEK DVF+FGIV
Sbjct: 479 FGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIV 538
Query: 247 LCELIARVPADPDYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAPFT 305
LCE+I RV ADPDYLPRT DFGL+V F +CP F + + CC+L+P R F
Sbjct: 539 LCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFV 598
Query: 306 EITQHLEWILEQLPEPAPL 324
++ LE + L PL
Sbjct: 599 KLEHWLETLRMHLAGHLPL 617
>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
Length = 686
Score = 224 bits (572), Expect = 1e-58
Identities = 127/286 (44%), Positives = 165/286 (57%), Gaps = 22/286 (7%)
Query: 37 RPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNR 94
R S R S + R D E +G GFF + KV H+ +G+VMV+K + +
Sbjct: 290 RSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ 349
Query: 95 GNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLH 154
L EV++M L HPN+L+F+GV +L+ LTEY+ GGTL+ L S +P W ++
Sbjct: 350 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVR 409
Query: 155 LALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGA---- 210
A IA G+ YLHS + HRDL S NCL++ + T VV DFGL+ I R+ A
Sbjct: 410 FAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEK 466
Query: 211 ------------RKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
RK+ VVG+PYWMAPE+L G+ YDE D+F+FGIVLCE+I +V ADP
Sbjct: 467 ATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADP 526
Query: 259 DYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAP 303
D LPRT DFGL+V F V DCP F LA CC LEP +RAP
Sbjct: 527 DCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAP 572
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 114 bits (286), Expect = 2e-25
Identities = 88/298 (29%), Positives = 140/298 (46%), Gaps = 26/298 (8%)
Query: 33 PGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNK--- 89
PG PS Y ++ A + E IG G F +VY R G + +K +
Sbjct: 123 PGGEDPSCYPPIQLLEIDFAELT---LEEIIGIGGFGKVY--RAFWIGDEVAVKAARHDP 177
Query: 90 ---LPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEP 146
+ N +E +L L+HPNI+ GVC+ + L + E+ GG L ++LS
Sbjct: 178 DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR- 236
Query: 147 LSWPVRLHLALDIARGLRYLHSKGV---FHRDLTSKNCLV-RREDRGFTA----VVGDFG 198
+ + ++ A+ IARG+ YLH + + HRDL S N L+ ++ + G + + DFG
Sbjct: 237 IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFG 296
Query: 199 LAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
LA RE R ++ G+ WMAPEV+R ++ + +DV+++G++L EL+
Sbjct: 297 LA------REWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFR 350
Query: 259 DYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILE 316
+G+ + + CP PF L C N +P +R FT I L I E
Sbjct: 351 GIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
Score = 31.6 bits (70), Expect = 2.3
Identities = 27/109 (24%), Positives = 42/109 (38%), Gaps = 6/109 (5%)
Query: 317 QLPEP----APLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSD--LFLPPSPESPPN 370
+LP+P P R T ++ R LPRP P +R R D F+ PS +
Sbjct: 974 RLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTS 1033
Query: 371 WGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLV 419
++ + P +L + + P P L P P T+ L+
Sbjct: 1034 PANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLL 1082
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 114 bits (285), Expect = 3e-25
Identities = 73/258 (28%), Positives = 122/258 (47%), Gaps = 9/258 (3%)
Query: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV 120
+++G+G F EV++ + V V + + + LRE Q+M LRHP +++ VC
Sbjct: 238 KRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCT 297
Query: 121 HQGQLHALTEYMNGGTLEQLLSSP--EPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTS 178
+ ++ +TE M G+L++ L + + ++ +A +A G+ YL S+ HRDL +
Sbjct: 298 LEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAA 357
Query: 179 KNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKA 238
+N LV + V DFGLA V E + + W APE +R + K+
Sbjct: 358 RNVLVGEHN---IYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKS 414
Query: 239 DVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEP 298
DV++FGI+L E+I + + + +R +CP F + + C N EP
Sbjct: 415 DVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEP 474
Query: 299 STRAPFTEITQHLEWILE 316
R F + L W LE
Sbjct: 475 KERPTF----ETLRWKLE 488
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 112 bits (281), Expect = 8e-25
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 8/213 (3%)
Query: 100 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDI 159
+++ + +L+HPNI+ F GVC L E+ G L ++L + P++ + + ++ I
Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 220
Query: 160 ARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVG 219
A G+ YLH + HRDL S N L+ +D + DFG ++++ + ++ G
Sbjct: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDD---VVKISDFGTSKEL-----SDKSTKMSFAG 272
Query: 220 SPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVG 279
+ WMAPEV+R E EK D+++FG+VL EL+ D +G+ + V
Sbjct: 273 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP 332
Query: 280 DDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLE 312
CP F +L C N +P R F +I HL+
Sbjct: 333 SSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 112 bits (279), Expect = 1e-24
Identities = 80/271 (29%), Positives = 131/271 (48%), Gaps = 24/271 (8%)
Query: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTL------REVQLMNRLRHPNILR 114
E IG G F +VY+ R G+ + +K +L + + +E +L L+HPNI+
Sbjct: 102 EIIGVGGFGKVYRALWR--GEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIA 159
Query: 115 FMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKG---V 171
G C++ L + EY GG L ++L+ + V ++ A+ +ARG+ YLH+ +
Sbjct: 160 LRGACLNPPHLCLVMEYARGGALSRVLAGRR-VPPHVLVNWAVQVARGMNYLHNDAPVPI 218
Query: 172 FHRDLTSKNCLVRREDRGFTAV-----VGDFGLAEKIPVYREGARKEPLAVVGSPYWMAP 226
HRDL S N L+ + DFGLA RE + ++ G+ WMAP
Sbjct: 219 IHRDLKSINILILEAIENHNLADTVLKITDFGLA------REWHKTTKMSAAGTYAWMAP 272
Query: 227 EVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPF 286
EV+R L+ + +DV++FG++L EL+ + +G+ + + CP PF
Sbjct: 273 EVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPF 332
Query: 287 LLLAIHCCNLEPSTRAPFTEITQHLEWILEQ 317
L C + +P R F I + LE ++EQ
Sbjct: 333 ARLLEECWDPDPHGRPDFGSILKRLE-VIEQ 362
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 111 bits (278), Expect = 2e-24
Identities = 84/279 (30%), Positives = 131/279 (46%), Gaps = 36/279 (12%)
Query: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRG------NTLREVQLMNRLRHPNILR 114
E IGAG F +VY+ + GQ + +K + + + RE +L LRHPNI+
Sbjct: 128 ELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIE 185
Query: 115 FMGVCVHQGQLHALTEYMNGGTLEQLL----SSPEP----------LSWPVRLHLALDIA 160
GVC+ Q L + E+ GG L + L ++P+P + V ++ A+ IA
Sbjct: 186 LRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIA 245
Query: 161 RGLRYLHSKG---VFHRDLTSKNCL----VRRED-RGFTAVVGDFGLAEKIPVYREGARK 212
RG+ YLH + + HRDL S N L + +D T + DFGLA RE R
Sbjct: 246 RGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA------REWHRT 299
Query: 213 EPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVP 272
++ G+ WMAPEV++ L+ + +D++++G++L EL+ +G+ V
Sbjct: 300 TKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVN 359
Query: 273 AFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL 311
+ CP PF L C +P R F I + L
Sbjct: 360 KLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 398
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 110 bits (276), Expect = 3e-24
Identities = 87/301 (28%), Positives = 134/301 (44%), Gaps = 59/301 (19%)
Query: 61 EKIGAGFFSEVY-------------------KVRHRQSGQVMVLKMNKLPSNRGNTLREV 101
EK+G G F EV+ + H V +L+ + + R + L+EV
Sbjct: 577 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEV 636
Query: 102 QLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE---------------- 145
++M+RL+ PNI+R +GVCV L +T+YM G L Q LS+ +
Sbjct: 637 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 696
Query: 146 ---PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEK 202
+S+P+ LH+A IA G+RYL + HRDL ++NCLV FT + DFG++
Sbjct: 697 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---GENFTIKIADFGMSRN 753
Query: 203 I---PVYR-EGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
+ YR +G P+ WMA E + + +DV+AFG+ L E++ A P
Sbjct: 754 LYAGDYYRVQGRAVLPIR------WMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP 807
Query: 259 DYLPRTEDFGLDVPAFRTLVGDD--------CPLPFLLLAIHCCNLEPSTRAPFTEITQH 310
E + F G CP L + C + E R PF+++ +
Sbjct: 808 FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRF 867
Query: 311 L 311
L
Sbjct: 868 L 868
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/100 (26%), Positives = 36/100 (36%), Gaps = 11/100 (11%)
Query: 363 PSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLD--TPSKPVLPLVPPSPFPSTQLPLVT 420
P P PP + + R NP + G D P KP PL+PP P +P
Sbjct: 476 PGPREPPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPP--PQNSVPHYA 533
Query: 421 TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAV 460
+ + G ++P+ P G GPP V
Sbjct: 534 EADIVTLQGVTGGNTYAVPALP-------PGAVGDGPPRV 566
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 110 bits (276), Expect = 3e-24
Identities = 87/301 (28%), Positives = 134/301 (44%), Gaps = 59/301 (19%)
Query: 61 EKIGAGFFSEVY-------------------KVRHRQSGQVMVLKMNKLPSNRGNTLREV 101
EK+G G F EV+ + H V +L+ + + R + L+EV
Sbjct: 614 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEV 673
Query: 102 QLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE---------------- 145
++M+RL+ PNI+R +GVCV L +T+YM G L Q LS+ +
Sbjct: 674 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 733
Query: 146 ---PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEK 202
+S+P+ LH+A IA G+RYL + HRDL ++NCLV FT + DFG++
Sbjct: 734 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---GENFTIKIADFGMSRN 790
Query: 203 I---PVYR-EGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
+ YR +G P+ WMA E + + +DV+AFG+ L E++ A P
Sbjct: 791 LYAGDYYRVQGRAVLPIR------WMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP 844
Query: 259 DYLPRTEDFGLDVPAFRTLVGDD--------CPLPFLLLAIHCCNLEPSTRAPFTEITQH 310
E + F G CP L + C + E R PF+++ +
Sbjct: 845 FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRF 904
Query: 311 L 311
L
Sbjct: 905 L 905
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 110 bits (276), Expect = 3e-24
Identities = 90/308 (29%), Positives = 140/308 (45%), Gaps = 36/308 (11%)
Query: 30 GGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNK 89
GGGP +S++ LR E IG G F +VY+ R G+++ +K +
Sbjct: 103 GGGPPPCEVASFQELR-------------LEEVIGIGGFGKVYRGSWR--GELVAVKAAR 147
Query: 90 LPSNRGNTL------REVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSS 143
+ ++ +E +L L HPNI+ VC+ + L + EY GG L + L+
Sbjct: 148 QDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAG 207
Query: 144 PEPLSWPVRLHLALDIARGLRYLHSKG---VFHRDLTSKNCL----VRREDRGF-TAVVG 195
+ V ++ A+ IARG+ YLH + V HRDL S N L + +D T +
Sbjct: 208 RR-VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKIT 266
Query: 196 DFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVP 255
DFGLA RE + ++ G+ WMAPEV++ + + +DV++FG++L EL+
Sbjct: 267 DFGLA------REWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEV 320
Query: 256 ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWIL 315
+G+ V + CP PF L C +P R F I Q LE +
Sbjct: 321 PYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALE 380
Query: 316 EQLPEPAP 323
Q+ P
Sbjct: 381 AQVLREMP 388
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 108 bits (271), Expect = 1e-23
Identities = 87/297 (29%), Positives = 138/297 (46%), Gaps = 21/297 (7%)
Query: 37 RPSSYRALRSAVSSLAR------VDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL 90
RP +SA LAR + +IG G F V + + GQ + +K K
Sbjct: 168 RPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYL--GQKVAVKNIKC 225
Query: 91 PSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEP--LS 148
L E +M +++H N++R +GV +HQG L+ + E+++ G L L + ++
Sbjct: 226 DVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVN 284
Query: 149 WPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYRE 208
L +L +A G+ YL SK + HRDL ++N LV + A V DFGLA+ R+
Sbjct: 285 TAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSED---LVAKVSDFGLAK---AERK 338
Query: 209 GARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFG 268
G L V W APE L+ + K+DV++FG++L E+ + A + E
Sbjct: 339 GLDSSRLPV----KWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSE 394
Query: 269 LDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLT 325
+R + CP P +L C EP+ R PF ++ + L L PA ++
Sbjct: 395 AVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVS 451
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 108 bits (271), Expect = 1e-23
Identities = 87/297 (29%), Positives = 138/297 (46%), Gaps = 21/297 (7%)
Query: 37 RPSSYRALRSAVSSLAR------VDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL 90
RP +SA LAR + +IG G F V + + GQ + +K K
Sbjct: 210 RPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYL--GQKVAVKNIKC 267
Query: 91 PSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEP--LS 148
L E +M +++H N++R +GV +HQG L+ + E+++ G L L + ++
Sbjct: 268 DVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVN 326
Query: 149 WPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYRE 208
L +L +A G+ YL SK + HRDL ++N LV + A V DFGLA+ R+
Sbjct: 327 TAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSED---LVAKVSDFGLAK---AERK 380
Query: 209 GARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFG 268
G L V W APE L+ + K+DV++FG++L E+ + A + E
Sbjct: 381 GLDSSRLPV----KWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSE 436
Query: 269 LDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLT 325
+R + CP P +L C EP+ R PF ++ + L L PA ++
Sbjct: 437 AVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVS 493
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 108 bits (271), Expect = 1e-23
Identities = 87/297 (29%), Positives = 138/297 (46%), Gaps = 21/297 (7%)
Query: 37 RPSSYRALRSAVSSLAR------VDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL 90
RP +SA LAR + +IG G F V + + GQ + +K K
Sbjct: 209 RPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYL--GQKVAVKNIKC 266
Query: 91 PSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEP--LS 148
L E +M +++H N++R +GV +HQG L+ + E+++ G L L + ++
Sbjct: 267 DVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVN 325
Query: 149 WPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYRE 208
L +L +A G+ YL SK + HRDL ++N LV + A V DFGLA+ R+
Sbjct: 326 TAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSED---LVAKVSDFGLAK---AERK 379
Query: 209 GARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFG 268
G L V W APE L+ + K+DV++FG++L E+ + A + E
Sbjct: 380 GLDSSRLPV----KWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSE 435
Query: 269 LDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLT 325
+R + CP P +L C EP+ R PF ++ + L L PA ++
Sbjct: 436 AVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVS 492
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 108 bits (271), Expect = 1e-23
Identities = 81/273 (29%), Positives = 130/273 (47%), Gaps = 15/273 (5%)
Query: 44 LRSAVSSLARVDD---FHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRG---NT 97
LR + +RVD F ++IG G F EVYK + +V+ +K+ L +
Sbjct: 4 LRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDI 63
Query: 98 LREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLAL 157
+E+ ++++ P I R+ G + +L + EY+ GG+ LL P PL +
Sbjct: 64 QQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILR 122
Query: 158 DIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
+I +GL YLHS+ HRD+ + N L+ + + DFG+A ++ + +
Sbjct: 123 EILKGLDYLHSERKIHRDIKAANVLLSEQG---DVKLADFGVAGQLT----DTQIKRNTF 175
Query: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTL 277
VG+P+WMAPEV++ YD KAD+++ GI EL P + D P F + + TL
Sbjct: 176 VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTL 235
Query: 278 VGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQH 310
G PF C N +P R E+ +H
Sbjct: 236 EGQHSK-PFKEFVEACLNKDPRFRPTAKELLKH 267
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 108 bits (270), Expect = 1e-23
Identities = 95/308 (30%), Positives = 148/308 (48%), Gaps = 38/308 (12%)
Query: 56 DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTL----------REVQLMN 105
+FH E IG+G F +VYK R R K+ + R NT REV ++
Sbjct: 464 EFH--EIIGSGSFGKVYKGRCRN-------KIVAIKRYRANTYCSKSDVDMFCREVSILC 514
Query: 106 RLRHPNILRFMGVCVHQ-GQLHALTEYMNGGTLEQLLSSPEP-LSWPVRLHLALDIARGL 163
+L HP +++F+G C++ Q +T+Y++GG+L LL + L +L +A+D+A+G+
Sbjct: 515 QLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGM 574
Query: 164 RYLH--SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI-PVYREGARKEPLAVVGS 220
YLH ++ + HRDL S N L+ + AVV DFG + + + + K+P G+
Sbjct: 575 EYLHNLTQPIIHRDLNSHNILLYEDGH---AVVADFGESRFLQSLDEDNMTKQP----GN 627
Query: 221 PYWMAPEVL-RGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVG 279
WMAPEV + Y KADVF++ + L E++ P + R +G
Sbjct: 628 LRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 687
Query: 280 DDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRT---ALTHNQGS- 335
P P L I N P R F+E+ LE L + +P + +L+ + S
Sbjct: 688 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSD 747
Query: 336 --VARGGP 341
V RGGP
Sbjct: 748 CLVNRGGP 755
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 108 bits (270), Expect = 1e-23
Identities = 95/308 (30%), Positives = 148/308 (48%), Gaps = 38/308 (12%)
Query: 56 DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTL----------REVQLMN 105
+FH E IG+G F +VYK R R K+ + R NT REV ++
Sbjct: 565 EFH--EIIGSGSFGKVYKGRCRN-------KIVAIKRYRANTYCSKSDVDMFCREVSILC 615
Query: 106 RLRHPNILRFMGVCVHQ-GQLHALTEYMNGGTLEQLLSSPEP-LSWPVRLHLALDIARGL 163
+L HP +++F+G C++ Q +T+Y++GG+L LL + L +L +A+D+A+G+
Sbjct: 616 QLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGM 675
Query: 164 RYLH--SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI-PVYREGARKEPLAVVGS 220
YLH ++ + HRDL S N L+ + AVV DFG + + + + K+P G+
Sbjct: 676 EYLHNLTQPIIHRDLNSHNILLYEDGH---AVVADFGESRFLQSLDEDNMTKQP----GN 728
Query: 221 PYWMAPEVL-RGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVG 279
WMAPEV + Y KADVF++ + L E++ P + R +G
Sbjct: 729 LRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 788
Query: 280 DDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRT---ALTHNQGS- 335
P P L I N P R F+E+ LE L + +P + +L+ + S
Sbjct: 789 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSD 848
Query: 336 --VARGGP 341
V RGGP
Sbjct: 849 CLVNRGGP 856
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 107 bits (268), Expect = 3e-23
Identities = 76/265 (28%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 61 EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREV--------QLMNRLRHPNI 112
++IG G FS Y+ + +G +M +K N + EV ++M+ L HPNI
Sbjct: 1247 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 1306
Query: 113 LRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVF 172
+R +G + + E+M GG++ LLS V ++ + RGL YLH +
Sbjct: 1307 IRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQII 1366
Query: 173 HRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGE 232
HRD+ N L+ + G + DFG A ++ GA + ++G+ +MAPEVLRG+
Sbjct: 1367 HRDVKGANLLI--DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQ 1424
Query: 233 LYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCP-LPFLL--- 288
Y DV++ G C +I A P + L + F+ P +P L
Sbjct: 1425 QYGRSCDVWSVG---CAIIEMACAKPPWNAEKHSNHLAL-IFKIASATTAPSIPSHLSPG 1480
Query: 289 ---LAIHCCNLEPSTRAPFTEITQH 310
+A+ C L+P R P E+ +H
Sbjct: 1481 LRDVALRCLELQPQDRPPSRELLKH 1505
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 107 bits (268), Expect = 3e-23
Identities = 69/213 (32%), Positives = 113/213 (53%), Gaps = 12/213 (5%)
Query: 55 DDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTL--REVQLMNRLRHPNI 112
+DF ++IG+G + +VYK R+ +G++ +K+ KL + +E+ +M +HPNI
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNI 73
Query: 113 LRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVF 172
+ + G + + +L E+ GG+L+ + PLS +++ + +GL YLHSKG
Sbjct: 74 VAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKM 133
Query: 173 HRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGE 232
HRD+ N L+ D G + DFG++ +I RK + +G+PYWMAPEV E
Sbjct: 134 HRDIKGANILL--TDNGHVK-LADFGVSAQITA-TIAKRK---SFIGTPYWMAPEVAAVE 186
Query: 233 L---YDEKADVFAFGIVLCELIARVPADPDYLP 262
Y++ D++A GI EL P D P
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHP 219
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 107 bits (267), Expect = 3e-23
Identities = 77/250 (30%), Positives = 118/250 (47%), Gaps = 40/250 (16%)
Query: 93 NRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE------- 145
+R + L+EV++M+RL+ PNI+R +GVCV L +T+YM G L Q LS+ +
Sbjct: 671 SRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAE 730
Query: 146 ------------PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193
+S+P+ LH+A IA G+RYL + HRDL ++NCLV FT
Sbjct: 731 GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---GENFTIK 787
Query: 194 VGDFGLAEKI---PVYR-EGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCE 249
+ DFG++ + YR +G P+ WMA E + + +DV+AFG+ L E
Sbjct: 788 IADFGMSRNLYAGDYYRVQGRAVLPIR------WMAWECILMGKFTTASDVWAFGVTLWE 841
Query: 250 LIARVPADPDYLPRTEDFGLDVPAFRTLVGDD--------CPLPFLLLAIHCCNLEPSTR 301
++ A P E + F G CP L + C + E R
Sbjct: 842 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 901
Query: 302 APFTEITQHL 311
PF+++ + L
Sbjct: 902 PPFSQLHRFL 911
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 107 bits (267), Expect = 3e-23
Identities = 93/318 (29%), Positives = 144/318 (45%), Gaps = 42/318 (13%)
Query: 63 IGAGFFSEVYKV--------RHRQSGQVMV--LKMNKLPSNRGNTLREVQLMNRL-RHPN 111
+G G F +V + R Q+ V V LK N + + + E+++M + RH N
Sbjct: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492
Query: 112 ILRFMGVCVHQGQLHALTEYMNGGTLEQLL----------------SSPEPLSWPVRLHL 155
I+ +GVC +G L+ + E G L + L SS PLS+PV +
Sbjct: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552
Query: 156 ALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA---EKIPVYREGAR- 211
A +ARG++YL S+ HRDL ++N LV ++ + DFGLA I Y++ +
Sbjct: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGVHHIDYYKKTSNG 609
Query: 212 KEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDV 271
+ P+ WMAPE L +Y ++DV++FGI+L E+ + +P E F L
Sbjct: 610 RLPVK------WMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 663
Query: 272 PAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTH 331
R CP L C + PS R F ++ + L+ +L + E R LT
Sbjct: 664 EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLR--LTF 721
Query: 332 NQGSVARGGPSATLPRPD 349
S + G S+T D
Sbjct: 722 GPYSPSGGDASSTCSSSD 739
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 107 bits (267), Expect = 3e-23
Identities = 93/318 (29%), Positives = 144/318 (45%), Gaps = 42/318 (13%)
Query: 63 IGAGFFSEVYKV--------RHRQSGQVMV--LKMNKLPSNRGNTLREVQLMNRL-RHPN 111
+G G F +V + R Q+ V V LK N + + + E+++M + RH N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532
Query: 112 ILRFMGVCVHQGQLHALTEYMNGGTLEQLL----------------SSPEPLSWPVRLHL 155
I+ +GVC +G L+ + E G L + L SS PLS+PV +
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592
Query: 156 ALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA---EKIPVYREGAR- 211
A +ARG++YL S+ HRDL ++N LV ++ + DFGLA I Y++ +
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGVHHIDYYKKTSNG 649
Query: 212 KEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDV 271
+ P+ WMAPE L +Y ++DV++FGI+L E+ + +P E F L
Sbjct: 650 RLPVK------WMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 703
Query: 272 PAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTH 331
R CP L C + PS R F ++ + L+ +L + E R LT
Sbjct: 704 EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLR--LTF 761
Query: 332 NQGSVARGGPSATLPRPD 349
S + G S+T D
Sbjct: 762 GPYSPSGGDASSTCSSSD 779
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 107 bits (267), Expect = 3e-23
Identities = 93/318 (29%), Positives = 144/318 (45%), Gaps = 42/318 (13%)
Query: 63 IGAGFFSEVYKV--------RHRQSGQVMV--LKMNKLPSNRGNTLREVQLMNRL-RHPN 111
+G G F +V + R Q+ V V LK N + + + E+++M + RH N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532
Query: 112 ILRFMGVCVHQGQLHALTEYMNGGTLEQLL----------------SSPEPLSWPVRLHL 155
I+ +GVC +G L+ + E G L + L SS PLS+PV +
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592
Query: 156 ALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA---EKIPVYREGAR- 211
A +ARG++YL S+ HRDL ++N LV ++ + DFGLA I Y++ +
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDN---VMKIADFGLARGVHHIDYYKKTSNG 649
Query: 212 KEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDV 271
+ P+ WMAPE L +Y ++DV++FGI+L E+ + +P E F L
Sbjct: 650 RLPVK------WMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 703
Query: 272 PAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTH 331
R CP L C + PS R F ++ + L+ +L + E R LT
Sbjct: 704 EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLR--LTF 761
Query: 332 NQGSVARGGPSATLPRPD 349
S + G S+T D
Sbjct: 762 GPYSPSGGDASSTCSSSD 779
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 106 bits (264), Expect = 7e-23
Identities = 86/283 (30%), Positives = 128/283 (45%), Gaps = 22/283 (7%)
Query: 46 SAVSSLARVD--DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQL 103
S V + +D + E +G G F V K + R + +K + S R + E++
Sbjct: 23 SQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVELRQ 80
Query: 104 MNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL---ALDIA 160
++R+ HPNI++ G C++ L + EY GG+L +L EPL + H L +
Sbjct: 81 LSRVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 138
Query: 161 RGLRYLHS---KGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
+G+ YLHS K + HRDL N L+ G + DFG A I + +
Sbjct: 139 QGVAYLHSMQPKALIHRDLKPPNLLLVAG--GTVLKICDFGTACDIQTHMTNNK------ 190
Query: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA-RVPADPDYLPRTEDFGLDVPAFRT 276
GS WMAPEV G Y EK DVF++GI+L E+I R P D P R
Sbjct: 191 -GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 277 LVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319
+ + P P L C + +PS R EI + + ++ P
Sbjct: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 292
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 106 bits (264), Expect = 7e-23
Identities = 86/283 (30%), Positives = 128/283 (45%), Gaps = 22/283 (7%)
Query: 46 SAVSSLARVD--DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQL 103
S V + +D + E +G G F V K + R + +K + S R + E++
Sbjct: 23 SQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVELRQ 80
Query: 104 MNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL---ALDIA 160
++R+ HPNI++ G C++ L + EY GG+L +L EPL + H L +
Sbjct: 81 LSRVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 138
Query: 161 RGLRYLHS---KGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
+G+ YLHS K + HRDL N L+ G + DFG A I + +
Sbjct: 139 QGVAYLHSMQPKALIHRDLKPPNLLLVAG--GTVLKICDFGTACDIQTHMTNNK------ 190
Query: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA-RVPADPDYLPRTEDFGLDVPAFRT 276
GS WMAPEV G Y EK DVF++GI+L E+I R P D P R
Sbjct: 191 -GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 277 LVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319
+ + P P L C + +PS R EI + + ++ P
Sbjct: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 292
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 106 bits (264), Expect = 7e-23
Identities = 86/283 (30%), Positives = 128/283 (45%), Gaps = 22/283 (7%)
Query: 46 SAVSSLARVD--DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQL 103
S V + +D + E +G G F V K + R + +K + S R + E++
Sbjct: 23 SQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVELRQ 80
Query: 104 MNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL---ALDIA 160
++R+ HPNI++ G C++ L + EY GG+L +L EPL + H L +
Sbjct: 81 LSRVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 138
Query: 161 RGLRYLHS---KGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
+G+ YLHS K + HRDL N L+ G + DFG A I + +
Sbjct: 139 QGVAYLHSMQPKALIHRDLKPPNLLLVAG--GTVLKICDFGTACDIQTHMTNNK------ 190
Query: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA-RVPADPDYLPRTEDFGLDVPAFRT 276
GS WMAPEV G Y EK DVF++GI+L E+I R P D P R
Sbjct: 191 -GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 277 LVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319
+ + P P L C + +PS R EI + + ++ P
Sbjct: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 292
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 106 bits (264), Expect = 7e-23
Identities = 86/283 (30%), Positives = 128/283 (45%), Gaps = 22/283 (7%)
Query: 46 SAVSSLARVD--DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQL 103
S V + +D + E +G G F V K + R + +K + S R + E++
Sbjct: 23 SQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVELRQ 80
Query: 104 MNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL---ALDIA 160
++R+ HPNI++ G C++ L + EY GG+L +L EPL + H L +
Sbjct: 81 LSRVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 138
Query: 161 RGLRYLHS---KGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
+G+ YLHS K + HRDL N L+ G + DFG A I + +
Sbjct: 139 QGVAYLHSMQPKALIHRDLKPPNLLLVAG--GTVLKICDFGTACDIQTHMTNNK------ 190
Query: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIA-RVPADPDYLPRTEDFGLDVPAFRT 276
GS WMAPEV G Y EK DVF++GI+L E+I R P D P R
Sbjct: 191 -GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 277 LVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319
+ + P P L C + +PS R EI + + ++ P
Sbjct: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 292
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.138 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,989,769
Number of Sequences: 37866
Number of extensions: 2508291
Number of successful extensions: 32314
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 844
Number of HSP's successfully gapped in prelim test: 1298
Number of HSP's that attempted gapping in prelim test: 16369
Number of HSP's gapped (non-prelim): 13643
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.