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Search of human proteins with 6466450
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6466450 catechol-O-methyltransferase isoform S-COMT [Homo
sapiens]
(221 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6466450 catechol-O-methyltransferase isoform S-COMT [Homo sap... 451 e-127
gi|205830453 catechol-O-methyltransferase isoform MB-COMT [Homo ... 451 e-127
gi|205830451 catechol-O-methyltransferase isoform MB-COMT [Homo ... 451 e-127
gi|4502969 catechol-O-methyltransferase isoform MB-COMT [Homo sa... 451 e-127
gi|223718169 leucine rich transmembrane and 0-methyltransferase ... 160 8e-40
gi|223718164 leucine rich transmembrane and 0-methyltransferase ... 160 8e-40
gi|223718159 leucine rich transmembrane and 0-methyltransferase ... 160 8e-40
gi|31542747 catechol-O-methyltransferase domain containing 1 [Ho... 40 0.002
gi|87159829 N-6 adenine-specific DNA methyltransferase 1 isoform... 30 1.2
gi|37537710 La ribonucleoprotein domain family, member 6 isoform... 30 1.6
gi|151301096 trimethylguanosine synthase homolog [Homo sapiens] 30 1.6
gi|87159831 N-6 adenine-specific DNA methyltransferase 1 isoform... 29 3.6
gi|169208036 PREDICTED: similar to Golgin subfamily A member 8-l... 28 6.2
gi|210147567 hypothetical protein LOC220081 [Homo sapiens] 28 6.2
gi|74271845 alpha-2-macroglobulin-like 1 [Homo sapiens] 28 8.1
>gi|6466450 catechol-O-methyltransferase isoform S-COMT [Homo
sapiens]
Length = 221
Score = 451 bits (1161), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 60
MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS
Sbjct: 1 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 60
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ
Sbjct: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
Query: 121 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 180
DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL
Sbjct: 121 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 180
Query: 181 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 221
AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Sbjct: 181 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 221
>gi|205830453 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 451 bits (1161), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 60
MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS
Sbjct: 51 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 110
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ
Sbjct: 111 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 170
Query: 121 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 180
DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL
Sbjct: 171 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 230
Query: 181 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 221
AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Sbjct: 231 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 271
>gi|205830451 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 451 bits (1161), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 60
MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS
Sbjct: 51 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 110
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ
Sbjct: 111 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 170
Query: 121 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 180
DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL
Sbjct: 171 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 230
Query: 181 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 221
AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Sbjct: 231 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 271
>gi|4502969 catechol-O-methyltransferase isoform MB-COMT [Homo
sapiens]
Length = 271
Score = 451 bits (1161), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 60
MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS
Sbjct: 51 MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPS 110
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ
Sbjct: 111 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 170
Query: 121 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 180
DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL
Sbjct: 171 DIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFL 230
Query: 181 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 221
AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Sbjct: 231 AHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP 271
>gi|223718169 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 6 [Homo sapiens]
Length = 251
Score = 160 bits (405), Expect = 8e-40
Identities = 81/213 (38%), Positives = 130/213 (61%), Gaps = 2/213 (0%)
Query: 6 EQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLEL 65
E+R ++VL HA PG+ +L +D + + E+ ++G KG+I+ +++E P+ +LEL
Sbjct: 39 EERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLEL 98
Query: 66 GAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKD-KVTLVVGASQDIIP 124
G YCGYS + +AR L PG RL+T+E +P AA+ ++++ AG + V L+VG+S+D+IP
Sbjct: 99 GTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIP 158
Query: 125 QLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVR 184
L+ +Y + D+V L H YL D LLE LL G +LAD+V+ PGAP FL + +
Sbjct: 159 CLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAK 218
Query: 185 GSSCFEC-THYQSFLEYREVVDGLEKAIYKGPG 216
+ C H+ ++ + DG+ + Y GPG
Sbjct: 219 SCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG 251
>gi|223718164 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 4 [Homo sapiens]
Length = 291
Score = 160 bits (405), Expect = 8e-40
Identities = 81/213 (38%), Positives = 130/213 (61%), Gaps = 2/213 (0%)
Query: 6 EQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLEL 65
E+R ++VL HA PG+ +L +D + + E+ ++G KG+I+ +++E P+ +LEL
Sbjct: 79 EERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLEL 138
Query: 66 GAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKD-KVTLVVGASQDIIP 124
G YCGYS + +AR L PG RL+T+E +P AA+ ++++ AG + V L+VG+S+D+IP
Sbjct: 139 GTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIP 198
Query: 125 QLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVR 184
L+ +Y + D+V L H YL D LLE LL G +LAD+V+ PGAP FL + +
Sbjct: 199 CLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAK 258
Query: 185 GSSCFEC-THYQSFLEYREVVDGLEKAIYKGPG 216
+ C H+ ++ + DG+ + Y GPG
Sbjct: 259 SCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG 291
>gi|223718159 leucine rich transmembrane and 0-methyltransferase
domain containing isoform 4 [Homo sapiens]
Length = 291
Score = 160 bits (405), Expect = 8e-40
Identities = 81/213 (38%), Positives = 130/213 (61%), Gaps = 2/213 (0%)
Query: 6 EQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLEL 65
E+R ++VL HA PG+ +L +D + + E+ ++G KG+I+ +++E P+ +LEL
Sbjct: 79 EERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLEL 138
Query: 66 GAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKD-KVTLVVGASQDIIP 124
G YCGYS + +AR L PG RL+T+E +P AA+ ++++ AG + V L+VG+S+D+IP
Sbjct: 139 GTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIP 198
Query: 125 QLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVR 184
L+ +Y + D+V L H YL D LLE LL G +LAD+V+ PGAP FL + +
Sbjct: 199 CLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAK 258
Query: 185 GSSCFEC-THYQSFLEYREVVDGLEKAIYKGPG 216
+ C H+ ++ + DG+ + Y GPG
Sbjct: 259 SCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG 291
>gi|31542747 catechol-O-methyltransferase domain containing 1 [Homo
sapiens]
Length = 262
Score = 39.7 bits (91), Expect = 0.002
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 58 QPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVG 117
Q L+LG + GYSA+ +A L R++T E++ + + + A + K+ L +
Sbjct: 102 QAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLK 161
Query: 118 ASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEEC-GLLRKGTVLLADNVICPGA 176
+ + + +L + T D+ +D K+ + E C LLR G +L V+ G
Sbjct: 162 PALETLDELLAAGEAGTFDVAVVDADKENC---SAYYERCLQLLRPGGILAVLRVLWRG- 217
Query: 177 PDFLAHVRGSSCFEC 191
L +G EC
Sbjct: 218 -KVLQPPKGDVAAEC 231
>gi|87159829 N-6 adenine-specific DNA methyltransferase 1 isoform 1
[Homo sapiens]
Length = 214
Score = 30.4 bits (67), Expect = 1.2
Identities = 18/72 (25%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQ 120
+ LE+G+ G + +A ++ P A + +INP+ AA T V + ++ +
Sbjct: 48 ICLEVGSGSGVVSAFLASMIGPQALYMCTDINPEAAACTLETARCNKVHIQ-PVITDLVK 106
Query: 121 DIIPQLKKKYDV 132
++P+L +K D+
Sbjct: 107 GLLPRLTEKVDL 118
>gi|37537710 La ribonucleoprotein domain family, member 6 isoform 1
[Homo sapiens]
Length = 491
Score = 30.0 bits (66), Expect = 1.6
Identities = 21/77 (27%), Positives = 35/77 (45%), Gaps = 12/77 (15%)
Query: 25 VLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGA 84
+L D Y K WA+ K G++ + V++ LL+L + + + R+L PG
Sbjct: 185 MLLVYDLYLSPKLWALATPQKNGRVQEKVMEH-----LLKL--FGTFGVISSVRILKPGR 237
Query: 85 RLITIEINPDCAAITQR 101
E+ PD I+ R
Sbjct: 238 -----ELPPDIRRISSR 249
>gi|151301096 trimethylguanosine synthase homolog [Homo sapiens]
Length = 853
Score = 30.0 bits (66), Expect = 1.6
Identities = 19/69 (27%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 49 IVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGV 108
I V Q + V+++ A+CG + L+ G R+I I+I+P A+ + + G+
Sbjct: 681 IAGRVSQSFKCDVVVD--AFCGVGGNTIQFALT-GMRVIAIDIDPVKIALARNNAEVYGI 737
Query: 109 KDKVTLVVG 117
DK+ + G
Sbjct: 738 ADKIEFICG 746
>gi|87159831 N-6 adenine-specific DNA methyltransferase 1 isoform
2 [Homo sapiens]
Length = 186
Score = 28.9 bits (63), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 61 VLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAIT 99
+ LE+G+ G + +A ++ P A + +INP+ AA T
Sbjct: 48 ICLEVGSGSGVVSAFLASMIGPQALYMCTDINPEAAACT 86
>gi|169208036 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 601
Score = 28.1 bits (61), Expect = 6.2
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 4/54 (7%)
Query: 117 GASQDIIPQLKKKYDVDTL---DMVFLDHWKDRYLPDT-LLLEECGLLRKGTVL 166
G S + LK+K D+ L ++ F+ HW+DR T LL E G K L
Sbjct: 424 GESSSFMDHLKEKADLSELVKKELCFIHHWRDRRHQKTHHLLSEPGGCAKDAAL 477
>gi|210147567 hypothetical protein LOC220081 [Homo sapiens]
Length = 696
Score = 28.1 bits (61), Expect = 6.2
Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 34 EQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINP 93
EQK+ +N+G + ++ V+ E + +LE A G +A ++ LL RL+ P
Sbjct: 611 EQKQICLNLGTRYKFVIPEVLSEMKKKTILE--AEPGPTAQKIRVLLGKMNRLLNYATTP 668
Query: 94 D 94
D
Sbjct: 669 D 669
>gi|74271845 alpha-2-macroglobulin-like 1 [Homo sapiens]
Length = 1454
Score = 27.7 bits (60), Expect = 8.1
Identities = 16/59 (27%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 54 IQEHQPSVLLELGAYCGYSAVRMARL-LSPGARLITIEINPDCAAITQRMVDFAGVKDK 111
I E P+ L+ L A + +V+ L LSPG + + + TQ++++++G+K +
Sbjct: 16 IAEELPNYLVTLPARLNFPSVQKVCLDLSPGYSDVKFTVTLETKDKTQKLLEYSGLKKR 74
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,862,815
Number of Sequences: 37866
Number of extensions: 373250
Number of successful extensions: 773
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 756
Number of HSP's gapped (non-prelim): 16
length of query: 221
length of database: 18,247,518
effective HSP length: 98
effective length of query: 123
effective length of database: 14,536,650
effective search space: 1788007950
effective search space used: 1788007950
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.