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Search of human proteins with 63147424
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63147424 kazrin isoform A [Homo sapiens]
(421 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63147424 kazrin isoform A [Homo sapiens] 822 0.0
gi|157837985 kazrin isoform E [Homo sapiens] 790 0.0
gi|65301130 kazrin isoform B [Homo sapiens] 688 0.0
gi|65301128 kazrin isoform C [Homo sapiens] 645 0.0
gi|63999741 kazrin isoform C [Homo sapiens] 645 0.0
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 63 4e-10
gi|45439327 periplakin [Homo sapiens] 59 6e-09
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 58 1e-08
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 58 1e-08
gi|38044112 restin isoform b [Homo sapiens] 58 2e-08
gi|4506751 restin isoform a [Homo sapiens] 58 2e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 57 2e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 57 3e-08
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 57 3e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 56 5e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 56 7e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 56 7e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 9e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 9e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 9e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 9e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 9e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 9e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 9e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 9e-08
gi|16975496 cortactin binding protein 2 [Homo sapiens] 55 9e-08
gi|42794779 myosin 18A isoform b [Homo sapiens] 55 1e-07
gi|28416946 myosin 18A isoform a [Homo sapiens] 55 1e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 55 2e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 55 2e-07
>gi|63147424 kazrin isoform A [Homo sapiens]
Length = 421
Score = 822 bits (2124), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
Sbjct: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
Query: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
Sbjct: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
Query: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
Sbjct: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
Query: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
Sbjct: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
Query: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
Sbjct: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
Query: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
Sbjct: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
Query: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDAD 420
HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDAD
Sbjct: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDAD 420
Query: 421 W 421
W
Sbjct: 421 W 421
>gi|157837985 kazrin isoform E [Homo sapiens]
Length = 775
Score = 790 bits (2041), Expect = 0.0
Identities = 407/407 (100%), Positives = 407/407 (100%)
Query: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
Sbjct: 1 MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG 60
Query: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
Sbjct: 61 DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL 120
Query: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
Sbjct: 121 RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY 180
Query: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
Sbjct: 181 EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
Query: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
Sbjct: 241 AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH 300
Query: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
Sbjct: 301 PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL 360
Query: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD 407
HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD
Sbjct: 361 HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFD 407
>gi|65301130 kazrin isoform B [Homo sapiens]
Length = 415
Score = 688 bits (1775), Expect = 0.0
Identities = 360/402 (89%), Positives = 363/402 (90%), Gaps = 9/402 (2%)
Query: 29 ELTATNRRLAELSGGGGPGPGPGAAAS---ASAAGDSAATNMENPQLGAQ------VLLR 79
+L A G GP PG AA AAG P++ A VLLR
Sbjct: 14 QLAAQGEPAPSCGAGAGPARPPGPAACEQCVDAAGPGDRPRAGVPRVRADGDCSQPVLLR 73
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ
Sbjct: 74 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 133
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD
Sbjct: 134 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 193
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS
Sbjct: 194 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 253
Query: 260 LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV 319
LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV
Sbjct: 254 LAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSV 313
Query: 320 ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK 379
ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK
Sbjct: 314 ISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKK 373
Query: 380 KEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDADW 421
KEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDADW
Sbjct: 374 KEKMGFGSISRVFARGKQRKSLDPGLFDGTAPDYYIEEDADW 415
>gi|65301128 kazrin isoform C [Homo sapiens]
Length = 327
Score = 645 bits (1665), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 95 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 154
MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD
Sbjct: 1 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 60
Query: 155 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 214
LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE
Sbjct: 61 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 120
Query: 215 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 274
ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW
Sbjct: 121 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 180
Query: 275 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 334
VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP
Sbjct: 181 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 240
Query: 335 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 394
SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR
Sbjct: 241 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 300
Query: 395 GKQRKSLDPGLFDGTAPDYYIEEDADW 421
GKQRKSLDPGLFDGTAPDYYIEEDADW
Sbjct: 301 GKQRKSLDPGLFDGTAPDYYIEEDADW 327
>gi|63999741 kazrin isoform C [Homo sapiens]
Length = 327
Score = 645 bits (1665), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 95 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 154
MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD
Sbjct: 1 MKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTD 60
Query: 155 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 214
LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE
Sbjct: 61 LVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKE 120
Query: 215 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 274
ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW
Sbjct: 121 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEW 180
Query: 275 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 334
VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP
Sbjct: 181 VVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTP 240
Query: 335 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 394
SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR
Sbjct: 241 SDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFAR 300
Query: 395 GKQRKSLDPGLFDGTAPDYYIEEDADW 421
GKQRKSLDPGLFDGTAPDYYIEEDADW
Sbjct: 301 GKQRKSLDPGLFDGTAPDYYIEEDADW 327
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 63.2 bits (152), Expect = 4e-10
Identities = 55/194 (28%), Positives = 94/194 (48%), Gaps = 25/194 (12%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
A+ L EE R+QE LL Q K+ LAK + + + + E L + RVQ + E+ LAR
Sbjct: 701 AKETLEEERKRMQELESLLAQQKKALAKSITQEK-NRVKEALEEEQTRVQ--ELEERLAR 757
Query: 134 AKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVK- 192
KE L++ A KR E LES + +++D + Q ++ SE +
Sbjct: 758 QKEVLESSIAHEKRKAKE-------------ALESEKRKVQDLENHLTQQKEISESNIAY 804
Query: 193 ALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR----MKELEAELAMAKQSLA 248
K K+ +E+EK ++ ++ + T + +L+LK+ + +L LAM +++
Sbjct: 805 EKRKAKEAMEKEK----KKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQK 860
Query: 249 TLTKDVPKRHSLAM 262
T + K SLA+
Sbjct: 861 TKATESLKAESLAL 874
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/206 (23%), Positives = 99/206 (48%), Gaps = 22/206 (10%)
Query: 50 PGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGG 109
PGA A + + ++ +LL +EVSRL + + + K+++ +L+
Sbjct: 207 PGAVPPAEIYVEEDLAQQDKDEI--ILLLGKEVSRLSD-YEIESKYKDVIIANLQNEVAE 263
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEAL-QAMKADRKRLKGEKTDLVSQMQQLYA---- 164
S +V T R Q E+E+++ + L + + A +K ++ K+ +S +Q+ Y+
Sbjct: 264 LSQKVSETTTSR----QNEKEISQKCQVLDEDIDAKQKEIQSLKSQ-ISALQKGYSKVLC 318
Query: 165 -TLESREEQLRDFIRNYEQHRKESEDAVKALAK--EKDLLEREKWELRRQAKEATDHATA 221
TL R ++ ++N ++ K + +KD+L ++ E +Q KE H
Sbjct: 319 QTLSERNSEITS-LKNEGENLKRDNAITSGMVSSLQKDILAKD--EQVQQLKEEVSH--- 372
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
L+SQ KD++++ L + ++ K+ L
Sbjct: 373 LKSQNKDKDHQLEALGSRCSVLKEEL 398
Score = 39.7 bits (91), Expect = 0.005
Identities = 55/237 (23%), Positives = 99/237 (41%), Gaps = 45/237 (18%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDL-------EESQGGKSSEVLSATELRVQLAQKEQE 130
L +++ +EE+ L Q +++L L EE+Q K++E L A L ++L + E
Sbjct: 823 LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAE 882
Query: 131 LARAK-----------------EALQ-AMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
L K +ALQ ++ R + E + Q++Q T+ S EE+
Sbjct: 883 LETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEK 942
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
L + QH K+ E + L K+ D +E + D A ++ KD
Sbjct: 943 L----QKVTQHHKKIEGEIATL-KDNDPAPKE--------ERPQDPLVAPMTESSAKDMA 989
Query: 233 MKELEAELAMAKQSLAT-------LTKDVPKRHSLAMPGETVLNGNQEWVVQADLPL 282
+ L +L A++ + + L KD+ + HS LN Q+ ++ ++ L
Sbjct: 990 YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVL 1046
Score = 34.7 bits (78), Expect = 0.17
Identities = 37/125 (29%), Positives = 65/125 (52%), Gaps = 13/125 (10%)
Query: 61 DSAATNMENPQLGAQVLLREE-VSRLQEEV-HLLRQMKEMLAKDLE-ESQGGKSS---EV 114
D+A T+ L +L ++E V +L+EEV HL Q K+ KD + E+ G + S E
Sbjct: 341 DNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKD---KDHQLEALGSRCSVLKEE 397
Query: 115 LSATELRVQLAQ-KEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR---E 170
L + +L + +E+EL K +Q M+ + K+L+ E ++ + TL + E
Sbjct: 398 LKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVE 457
Query: 171 EQLRD 175
E+L++
Sbjct: 458 EKLQE 462
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 59.3 bits (142), Expect = 6e-09
Identities = 58/230 (25%), Positives = 106/230 (46%), Gaps = 37/230 (16%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEA-- 137
+E+ + QE+ ++ + AK EE + E A++ Q+A+KE+EL+R KE
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVV 1351
Query: 138 ------------------------------LQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ ++A+ +RL+ +T+L Q+++L +
Sbjct: 1352 QQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQ 1411
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+R E R+ R Q R + + +A A+EK + +K L++ ++A +HA LR QL+
Sbjct: 1412 ARREAEREVQR--LQQRLAALEQEEAEAREK-VTHTQKVVLQQDPQQAREHA-LLRLQLE 1467
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQ 277
+ +R + LE EL ++ LA L K K + V G+ E +Q
Sbjct: 1468 EEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQ 1517
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/187 (26%), Positives = 86/187 (45%), Gaps = 22/187 (11%)
Query: 77 LLREEVSRLQEEVHLLRQ----------MKEMLAKDLEESQGGKSSEVLSATE-LRVQLA 125
LL+EE+ LQ ++ L Q +KE+L + + +Q + ++ E LR Q
Sbjct: 966 LLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKG 1025
Query: 126 QKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRK 185
+E E+ ++ + A+ ++ R + + T+ Q LE+ +QL++ + +Q R+
Sbjct: 1026 AREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLRE 1085
Query: 186 ESE-------DAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEA 238
+ E D +K L KE+ + E K ++ K D AT R DL R E EA
Sbjct: 1086 KQEEELSFLQDKLKRLEKERAMAE-GKITVKEVLKVEKDAATE-REVSDL--TRQYEDEA 1141
Query: 239 ELAMAKQ 245
A A Q
Sbjct: 1142 AKARASQ 1148
Score = 35.4 bits (80), Expect = 0.098
Identities = 42/192 (21%), Positives = 81/192 (42%), Gaps = 23/192 (11%)
Query: 65 TNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQL 124
+ ME + LL E SR QE ++++ A + Q K E L A +LR L
Sbjct: 761 SQMETKLKNQKNLLDEIASREQE-------VQKICANSQQYQQAVKDYE-LEAEKLRSLL 812
Query: 125 AQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
+ + + + +++ ++K E+ L ++ ++YA R + L +F N + +
Sbjct: 813 DLENGRSSHVSKRAR-LQSPATKVKEEEAALAAKFTEVYAINRQRLQNL-EFALNLLRQQ 870
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
E E + L R + + A +R +LD + R ++LE E+ +
Sbjct: 871 PEVEVTHETLQ-------------RNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQ 917
Query: 245 QSLATLTKDVPK 256
+ + TL P+
Sbjct: 918 EEIWTLRNQGPQ 929
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/271 (21%), Positives = 114/271 (42%), Gaps = 11/271 (4%)
Query: 3 EDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASAS-AAGD 61
E+ K+ A + + QE++ EL A +L L+ S A +
Sbjct: 455 EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
Query: 62 SAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLA---------KDLEESQGGKSS 112
A ++ ++ L E+ + L ++ ++ M E KD+ + + K +
Sbjct: 515 QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
Query: 113 EVLSATE-LRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
+ E L+ QL KE++++ KE +++++AD T L + + T+E +E
Sbjct: 575 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 634
Query: 172 QLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDN 231
Q R ++ + +K L ++ LL+ + E + +HA++L S KD+
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 232 RMKELEAELAMAKQSLATLTKDVPKRHSLAM 262
R+K LE L K+ + + K H A+
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAAL 725
Score = 47.0 bits (110), Expect = 3e-05
Identities = 62/253 (24%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 79 REEVSRLQEEVHLLR---QMKEMLAKDLEESQGGKSSEVLSATE----LRVQLAQKEQE- 130
++++ L+E+V LL+ KE DL+E +S L L + L QK++E
Sbjct: 651 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC 710
Query: 131 ------LARAKEA-------------LQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
L +A EA +Q ++ + R K E + +++ +L L+ E
Sbjct: 711 LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 770
Query: 172 QLRDFIRNYEQHRKESEDAVKALA--KEKDLLEREKW-----ELRRQAKEATDHATALRS 224
+ D + + ++ +D K +A K K+ +E++K E RR+ D + L+
Sbjct: 771 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
Query: 225 QLDLKDNRMKELEAELAMAKQSLA----TLTKDVPKRHSLAMPGETVLNGNQEWVVQADL 280
L KD+R++ELE L + Q A L ++ R + E +L E V Q
Sbjct: 831 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA-MEKVKQELE 889
Query: 281 PLTAAIRQSQQTL 293
+ A + +QQ+L
Sbjct: 890 SMKAKLSSTQQSL 902
Score = 42.0 bits (97), Expect = 0.001
Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 29/215 (13%)
Query: 59 AGDSAATNMENPQLGAQVL-LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA 117
A ++A +P++ ++ L E++R ++E + + L + L+E + K+ +
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
Query: 118 TELRVQLAQKEQELARAKEALQAMKA-------DRKRLKGEKTDLVSQMQQLYATLESRE 170
EL Q+ + +++A K Q K + +R + D Q+Q + R
Sbjct: 780 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
Query: 171 EQLRDFIRNYEQ------------------HRKESEDAVKALAKEKDLLEREKWELRRQA 212
E+L + +R Q K+ E+ + A+ K K LE K +L
Sbjct: 840 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 899
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
+ + T L +L+ R K LE L M +++L
Sbjct: 900 QSLAEKETHL---TNLRAERRKHLEEVLEMKQEAL 931
Score = 38.5 bits (88), Expect = 0.012
Identities = 40/190 (21%), Positives = 88/190 (46%), Gaps = 18/190 (9%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQ---ELARAKEAL 138
+ LQ+E+ + R + ++ +D G L+ + A+ E+ EL ++ L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 139 QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEK 198
+ M+ + K +++L L+S+ + ++E+ R+ +E + E
Sbjct: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 199 DLLEREKW------ELRRQAKEATDHAT--ALRSQLDLKDNR-------MKELEAELAMA 243
L ++EK E+ R+ + A D A AL++ +++KD++ +++LE E+ M
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 244 KQSLATLTKD 253
K + A T++
Sbjct: 409 KSNGALSTEE 418
Score = 38.5 bits (88), Expect = 0.012
Identities = 53/255 (20%), Positives = 110/255 (43%), Gaps = 28/255 (10%)
Query: 74 AQVLLREEVSRLQEEVH-LLRQMKEMLAKD---LEESQGGKSSEVLSATELRVQLAQKEQ 129
AQ+L EE R ++ ++ +Q+++ L K +EE + V E + LAQ+E
Sbjct: 808 AQML--EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEES 865
Query: 130 ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKE--- 186
A++ ++ + +++K E + +++ +L +E L + +H +E
Sbjct: 866 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
Query: 187 -SEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
++A+ A EKD EL K+ + AL+ + KD +++L+ + +
Sbjct: 926 MKQEALLAAISEKD-ANIALLELSSSKKKTQEEVAALKRE---KDRLVQQLKQQTQNRMK 981
Query: 246 SLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQ 305
+A +D + S + +T + + ++Q L L +S+ LY H
Sbjct: 982 LMADNYEDDHFKSSHS--NQTNHKPSPDQIIQPLLELDQ--NRSKLKLYIGH-------- 1029
Query: 306 AVRVSPCHSRQPSVI 320
+ CH R P ++
Sbjct: 1030 --LTTLCHDRDPLIL 1042
Score = 34.7 bits (78), Expect = 0.17
Identities = 44/190 (23%), Positives = 80/190 (42%), Gaps = 36/190 (18%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQ-----LAQKEQELARA 134
E + +L E + Q K + AK EE + + L+ E+ V L QKE+E +
Sbjct: 307 ESIKKLLE----MLQSKGLSAKATEEDH--ERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 135 KEALQAM---KADRKRLKGEKT-----------------DLVSQMQQLYA----TLESRE 170
+E + D + K +T DL ++Q L + + E RE
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKD 230
E+++ + Y H K ++ V+ L +E E + EL+++A ++ +L KD
Sbjct: 421 EEMKQ-MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 231 NRMKELEAEL 240
+ L+ +L
Sbjct: 480 TELLALQTKL 489
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 15/185 (8%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL-------------DLKDNRMKE-LEAELAMAKQSLATLTKD 253
+RRQ +E H L+ QL +++++R E L+ +L + L +L D
Sbjct: 468 IRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHD 527
Query: 254 VPKRH 258
+ H
Sbjct: 528 HRRPH 532
Score = 36.6 bits (83), Expect = 0.044
Identities = 87/375 (23%), Positives = 136/375 (36%), Gaps = 70/375 (18%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE R +EE + + +E + + LEE Q + EVL L+ Q E +E Q
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQ--RHLEVLQQQLLQEQAMLLECRWREMEEHRQ 506
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
A + R Q+QQ A L S + D R + QH ++
Sbjct: 507 AERLQR------------QLQQEQAYLLSLQ---HDHRRPHPQHSQQPPPP--------- 542
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDN-RMKELEAELAMAKQSLATLTKDVPKRH 258
++E+ + A E H +++D R + A +KQ+ L VP R
Sbjct: 543 --QQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSR- 599
Query: 259 SLAMPGETVLNGNQEWV---------VQADLPLTAAIRQSQQTLYHSH-----PPHPADR 304
E+ NGN E V Q A+++ + + SH P A
Sbjct: 600 -----SESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHH 654
Query: 305 QAVRVSPCHSRQPSVISDASAAEGDR--------SSTPSDINSPR------HRTHSLCNG 350
PC + V+S +S ++ + S + SD PR R+ L
Sbjct: 655 HLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRR 714
Query: 351 DSP--GPVQKNLHNPIVQSLEDLEDQKRKKKKEKM----GFGSISRVFARGKQRKSLDPG 404
DSP G Q+N S +E + ++ EK+ G GS S G Q S PG
Sbjct: 715 DSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGS-HPG 773
Query: 405 LFDGTAPDYYIEEDA 419
G+ + + +
Sbjct: 774 SQSGSGERFRVRSSS 788
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.8 bits (138), Expect = 2e-08
Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 41/247 (16%)
Query: 23 VTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEV 82
+ N ++L AT +L +L A AS+ G S LR+++
Sbjct: 713 IDNFTSQLKATEEKLLDLD----------ALRKASSEGKSEMKK-----------LRQQL 751
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEAL--- 138
++++ L + K+ E S+ + L EL++ L + E+++ KE L
Sbjct: 752 EAAEKQIKHLE-----IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
Query: 139 -QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ----------LRDFIRNYEQHRKES 187
Q +K E + MQ+ L +EEQ LR+ + + E +E
Sbjct: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
++ + L K K+ LE + E+ + + + + T + +L LK+ ++EL+ +L A ++
Sbjct: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 926
Query: 248 ATLTKDV 254
+ L K +
Sbjct: 927 SFLQKSI 933
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 18/183 (9%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
+++++ +E+ L + E L L ++ S S ++ V+ Q +QE A+ E
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--- 953
Query: 141 MKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLR----DFIRNYEQHRKESED 189
++K L+ + +DL +M Q+L A E + + + ++N ++ ++ED
Sbjct: 954 ---EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1010
Query: 190 AVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+K +E L +E ELR+QA +A TA + + + KE LA + + T
Sbjct: 1011 KLKGAREENSGLLQELEELRKQADKAKAAQTA-EDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 250 LTK 252
K
Sbjct: 1070 NAK 1072
Score = 42.7 bits (99), Expect = 6e-04
Identities = 42/179 (23%), Positives = 88/179 (49%), Gaps = 18/179 (10%)
Query: 85 LQEEVHLLRQMKE---MLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEALQA 140
+QE V+ L Q +E ML+ DLE K E L+ E + + ++E++L +AKE L+
Sbjct: 828 MQETVNKLHQKEEQFNMLSSDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQH----RKESED-AVKALA 195
A+ ++ G+ + +++M E E+L+ + ++ +K ED VKA
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942
Query: 196 KEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+++ ++ + E + ++ +D L +++ N+ +EL+A A T +++
Sbjct: 943 SQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARYERATSETKTKHEEI 997
Score = 39.7 bits (91), Expect = 0.005
Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 34/261 (13%)
Query: 1 MMEDNKQLALRIDGAVQSASQEV----TNLRAELTATNRRLAELSGGGGPGPGPGAAASA 56
+ ++N+ L +++ A + S + + L + + + + EL G G A A
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLS 116
T +E +L Q E+ LQ + +D E + K E L
Sbjct: 612 ELK-----TQIEKMRLDYQ----HEIENLQNQ------------QDSERAAHAKEMEALR 650
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF 176
A ++V + +KE L + L KA+ + L E D ++++Q+ A ++ +E ++
Sbjct: 651 AKLMKV-IKEKENSLEAIRSKLD--KAEDQHLV-EMEDTLNKLQE--AEIKVKELEVLQA 704
Query: 177 IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
N EQ + + A E+ LL+ + LR+ + E LR QL+ + ++K L
Sbjct: 705 KCN-EQTKVIDNFTSQLKATEEKLLDLDA--LRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
Query: 237 EAELAMAKQSLATLTKDVPKR 257
E E +++T+++ R
Sbjct: 762 EIEKNAESSKASSITRELQGR 782
Score = 34.3 bits (77), Expect = 0.22
Identities = 31/140 (22%), Positives = 61/140 (43%)
Query: 118 TELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
TE + A+K +EAL+ + ++L E+ +++ + + + E++L
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE 237
++QH E E + L + +REK EL Q +E L+ +++ + +LE
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 238 AELAMAKQSLATLTKDVPKR 257
K + L KD+ R
Sbjct: 457 VATVSEKSRIMELEKDLALR 476
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.8 bits (138), Expect = 2e-08
Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 41/247 (16%)
Query: 23 VTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEV 82
+ N ++L AT +L +L A AS+ G S LR+++
Sbjct: 748 IDNFTSQLKATEEKLLDLD----------ALRKASSEGKSEMKK-----------LRQQL 786
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEAL--- 138
++++ L + K+ E S+ + L EL++ L + E+++ KE L
Sbjct: 787 EAAEKQIKHLE-----IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 841
Query: 139 -QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ----------LRDFIRNYEQHRKES 187
Q +K E + MQ+ L +EEQ LR+ + + E +E
Sbjct: 842 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 901
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
++ + L K K+ LE + E+ + + + + T + +L LK+ ++EL+ +L A ++
Sbjct: 902 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 961
Query: 248 ATLTKDV 254
+ L K +
Sbjct: 962 SFLQKSI 968
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 18/183 (9%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
+++++ +E+ L + E L L ++ S S ++ V+ Q +QE A+ E
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--- 988
Query: 141 MKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLR----DFIRNYEQHRKESED 189
++K L+ + +DL +M Q+L A E + + + ++N ++ ++ED
Sbjct: 989 ---EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1045
Query: 190 AVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+K +E L +E ELR+QA +A TA + + + KE LA + + T
Sbjct: 1046 KLKGAREENSGLLQELEELRKQADKAKAAQTA-EDAMQIMEQMTKEKTETLASLEDTKQT 1104
Query: 250 LTK 252
K
Sbjct: 1105 NAK 1107
Score = 42.7 bits (99), Expect = 6e-04
Identities = 42/179 (23%), Positives = 88/179 (49%), Gaps = 18/179 (10%)
Query: 85 LQEEVHLLRQMKE---MLAKDLEESQGGKSSEVLSATELRV-QLAQKEQELARAKEALQA 140
+QE V+ L Q +E ML+ DLE K E L+ E + + ++E++L +AKE L+
Sbjct: 863 MQETVNKLHQKEEQFNMLSSDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLEN 917
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQH----RKESED-AVKALA 195
A+ ++ G+ + +++M E E+L+ + ++ +K ED VKA
Sbjct: 918 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977
Query: 196 KEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+++ ++ + E + ++ +D L +++ N+ +EL+A A T +++
Sbjct: 978 SQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARYERATSETKTKHEEI 1032
Score = 39.7 bits (91), Expect = 0.005
Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 34/261 (13%)
Query: 1 MMEDNKQLALRIDGAVQSASQEV----TNLRAELTATNRRLAELSGGGGPGPGPGAAASA 56
+ ++N+ L +++ A + S + + L + + + + EL G G A A
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLS 116
T +E +L Q E+ LQ + +D E + K E L
Sbjct: 647 ELK-----TQIEKMRLDYQ----HEIENLQNQ------------QDSERAAHAKEMEALR 685
Query: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF 176
A ++V + +KE L + L KA+ + L E D ++++Q+ A ++ +E ++
Sbjct: 686 AKLMKV-IKEKENSLEAIRSKLD--KAEDQHLV-EMEDTLNKLQE--AEIKVKELEVLQA 739
Query: 177 IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
N EQ + + A E+ LL+ + LR+ + E LR QL+ + ++K L
Sbjct: 740 KCN-EQTKVIDNFTSQLKATEEKLLDLDA--LRKASSEGKSEMKKLRQQLEAAEKQIKHL 796
Query: 237 EAELAMAKQSLATLTKDVPKR 257
E E +++T+++ R
Sbjct: 797 EIEKNAESSKASSITRELQGR 817
Score = 36.6 bits (83), Expect = 0.044
Identities = 31/152 (20%), Positives = 66/152 (43%), Gaps = 6/152 (3%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAM 141
+ L++ + + + L ++LE+++ SE EL LA + QE+A + L++
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 525
Query: 142 K--ADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
K D ++ S ++L T + ++ ++ + + +KAL +
Sbjct: 526 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE 585
Query: 200 LLERE----KWELRRQAKEATDHATALRSQLD 227
L +E K +L KE +D +S+L+
Sbjct: 586 KLSKENESLKSKLEHANKENSDVIALWKSKLE 617
Score = 32.0 bits (71), Expect = 1.1
Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 14/151 (9%)
Query: 118 TELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
TE + A+K +EAL+ + ++L E+ +++ + + + E++L
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALR-------------- 223
++QH E E + L + +REK EL Q +E L+
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 224 SQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
+Q L+ R+KELE L K L +++
Sbjct: 457 TQTKLEHARIKELEQSLLFEKTKADKLQREL 487
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/207 (23%), Positives = 91/207 (43%), Gaps = 21/207 (10%)
Query: 77 LLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEV------LSATELRV----- 122
+L+ EV L+ EE + K +D+ E +G ++ E+ L E +V
Sbjct: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 550
Query: 123 -------QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRD 175
QL KE++++ KE +++++AD T L + + T+E +EQ
Sbjct: 551 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610
Query: 176 FIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKE 235
R ++ + +K L ++ LL+ + E + +HA++L S KD+R+K
Sbjct: 611 DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT 670
Query: 236 LEAELAMAKQSLATLTKDVPKRHSLAM 262
LE L K+ + + K H A+
Sbjct: 671 LEIALEQKKEECLKMESQLKKAHEAAL 697
Score = 47.0 bits (110), Expect = 3e-05
Identities = 62/253 (24%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 79 REEVSRLQEEVHLLR---QMKEMLAKDLEESQGGKSSEVLSATE----LRVQLAQKEQE- 130
++++ L+E+V LL+ KE DL+E +S L L + L QK++E
Sbjct: 623 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC 682
Query: 131 ------LARAKEA-------------LQAMKADRKRLKGEKTDLVSQMQQLYATLESREE 171
L +A EA +Q ++ + R K E + +++ +L L+ E
Sbjct: 683 LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 742
Query: 172 QLRDFIRNYEQHRKESEDAVKALA--KEKDLLEREKW-----ELRRQAKEATDHATALRS 224
+ D + + ++ +D K +A K K+ +E++K E RR+ D + L+
Sbjct: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 802
Query: 225 QLDLKDNRMKELEAELAMAKQSLA----TLTKDVPKRHSLAMPGETVLNGNQEWVVQADL 280
L KD+R++ELE L + Q A L ++ R + E +L E V Q
Sbjct: 803 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA-MEKVKQELE 861
Query: 281 PLTAAIRQSQQTL 293
+ A + +QQ+L
Sbjct: 862 SMKAKLSSTQQSL 874
Score = 42.0 bits (97), Expect = 0.001
Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 29/215 (13%)
Query: 59 AGDSAATNMENPQLGAQVL-LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA 117
A ++A +P++ ++ L E++R ++E + + L + L+E + K+ +
Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 751
Query: 118 TELRVQLAQKEQELARAKEALQAMKA-------DRKRLKGEKTDLVSQMQQLYATLESRE 170
EL Q+ + +++A K Q K + +R + D Q+Q + R
Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
Query: 171 EQLRDFIRNYEQ------------------HRKESEDAVKALAKEKDLLEREKWELRRQA 212
E+L + +R Q K+ E+ + A+ K K LE K +L
Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
+ + T L +L+ R K LE L M +++L
Sbjct: 872 QSLAEKETHL---TNLRAERRKHLEEVLEMKQEAL 903
Score = 38.5 bits (88), Expect = 0.012
Identities = 40/190 (21%), Positives = 88/190 (46%), Gaps = 18/190 (9%)
Query: 82 VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQ---ELARAKEAL 138
+ LQ+E+ + R + ++ +D G L+ + A+ E+ EL ++ L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
Query: 139 QAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEK 198
+ M+ + K +++L L+S+ + ++E+ R+ +E + E
Sbjct: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 199 DLLEREKW------ELRRQAKEATDHAT--ALRSQLDLKDNR-------MKELEAELAMA 243
L ++EK E+ R+ + A D A AL++ +++KD++ +++LE E+ M
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 244 KQSLATLTKD 253
K + A T++
Sbjct: 409 KSNGALSTEE 418
Score = 38.5 bits (88), Expect = 0.012
Identities = 53/255 (20%), Positives = 110/255 (43%), Gaps = 28/255 (10%)
Query: 74 AQVLLREEVSRLQEEVH-LLRQMKEMLAKD---LEESQGGKSSEVLSATELRVQLAQKEQ 129
AQ+L EE R ++ ++ +Q+++ L K +EE + V E + LAQ+E
Sbjct: 780 AQML--EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEES 837
Query: 130 ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKE--- 186
A++ ++ + +++K E + +++ +L +E L + +H +E
Sbjct: 838 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 897
Query: 187 -SEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
++A+ A EKD EL K+ + AL+ + KD +++L+ + +
Sbjct: 898 MKQEALLAAISEKD-ANIALLELSSSKKKTQEEVAALKRE---KDRLVQQLKQQTQNRMK 953
Query: 246 SLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQ 305
+A +D + S + +T + + ++Q L L +S+ LY H
Sbjct: 954 LMADNYEDDHFKSSHS--NQTNHKPSPDQIIQPLLELDQ--NRSKLKLYIGH-------- 1001
Query: 306 AVRVSPCHSRQPSVI 320
+ CH R P ++
Sbjct: 1002 --LTTLCHDRDPLIL 1014
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 57.0 bits (136), Expect = 3e-08
Identities = 39/139 (28%), Positives = 69/139 (49%), Gaps = 1/139 (0%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL 226
+RRQ +E H L+ QL
Sbjct: 468 IRRQLEEEQRHLEVLQQQL 486
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 57.0 bits (136), Expect = 3e-08
Identities = 39/139 (28%), Positives = 69/139 (49%), Gaps = 1/139 (0%)
Query: 88 EVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKR 147
E L R + ++ E S+ + ++L +LR Q K Q LA ++ ++ K R+R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 148 LKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWE 207
L+ ++ +Q RE++ + + E+ RKE E+ +A +EK +ERE+
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA-EEEKRRVEREQEY 467
Query: 208 LRRQAKEATDHATALRSQL 226
+RRQ +E H L+ QL
Sbjct: 468 IRRQLEEEQRHLEVLQQQL 486
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 56.2 bits (134), Expect = 5e-08
Identities = 59/218 (27%), Positives = 95/218 (43%), Gaps = 22/218 (10%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVH----LLRQMKEMLAKDLEESQGG 109
A+ A AAT + QL + R+E RL E+H L + +LA +LEE +
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRA- 1739
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR 169
L E +LA EQEL A E L + + L +K L + + QL +E
Sbjct: 1740 ----ALEQGERSRRLA--EQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 170 EEQLRDFIRNYE----------QHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA 219
++ R+ + + K+ +D L + K LE+ EL+ + +EA A
Sbjct: 1794 AQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Query: 220 -TALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ Q+ + +++ELEAEL ++ A K V K
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK 1891
Score = 49.3 bits (116), Expect = 7e-06
Identities = 45/161 (27%), Positives = 70/161 (43%), Gaps = 17/161 (10%)
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKG-------EKTDLVSQMQQL 162
K +L + + +LA EL + AL A +A R+ L+ EK DL Q+Q
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 163 YATLESREEQLRDFIRNYEQ---------HRKESEDAVKA-LAKEKDLLEREKWELRRQA 212
L EE+ I++ Q R E E+ V A LA + LE E EL++
Sbjct: 944 QDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDI 1003
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+ + +N++K L E+A +S+A LTK+
Sbjct: 1004 DDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1044
Score = 45.4 bits (106), Expect = 9e-05
Identities = 45/165 (27%), Positives = 82/165 (49%), Gaps = 11/165 (6%)
Query: 81 EVSRLQEE----VHLLRQMKEMLAKDLEE--SQGGKSSEVLSATELRVQLAQKEQELARA 134
E+SRL EE + L + K + A+ LEE Q + S+ SA VQ + + +L R
Sbjct: 1335 ELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 135 KEALQA-MKADRKRLKGEKTDLVSQMQQLY-ATLESREEQLRDFIRNYEQHRKESEDAVK 192
+ +A +A+ +RL + V+Q + Y A R E+L + + +E+E+ V+
Sbjct: 1395 QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVE 1454
Query: 193 ALAKEKDLLEREKWELRRQAKEAT---DHATALRSQLDLKDNRMK 234
A + LE+ K L+ ++++ T + AT+ + LD K ++
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499
Score = 45.1 bits (105), Expect = 1e-04
Identities = 84/398 (21%), Positives = 154/398 (38%), Gaps = 42/398 (10%)
Query: 2 MEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGD 61
++D K + + Q+ +V NL E+ A + +A L+ A A GD
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLT----KEKKALQEAHQQALGD 1058
Query: 62 -SAATNMENPQLGAQVLLREEVSRLQ---EEVHLLR----QMKEMLAKDLEESQGGKSSE 113
A + + A++ L ++V L+ E+ LR + K L DL+ +Q +
Sbjct: 1059 LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADA 1118
Query: 114 VLSATELRVQLAQKEQELARAKEALQ-------AMKADRKRLKGEKTDLVSQMQQLYATL 166
+L +L +K+ EL++ ++ M+ K L+ +L +++ A
Sbjct: 1119 AQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAAR 1178
Query: 167 ESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQL 226
E+Q + R E+ + E+A A A +++ + + EL R +E + ALR +
Sbjct: 1179 ARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEE--AALRHEA 1236
Query: 227 DLKDNRMKELE--AELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTA 284
+ R K+ E AEL SL + + + K S L N E + +A
Sbjct: 1237 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEK 1296
Query: 285 AIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRT 344
R + L ++V + ++DAS G + +++
Sbjct: 1297 LCRTYEDQL---------SEAKIKVEELQRQ----LADASTQRGRLQTESGELSRLLEEK 1343
Query: 345 HSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEK 382
L + S G QSLE+L Q ++ K K
Sbjct: 1344 ECLISQLSRGKAL------AAQSLEELRRQLEEESKAK 1375
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 43/274 (15%)
Query: 15 AVQSASQEVTNLRAELTATNRRLAEL---SGGGGPGPGPGAAASASAAG------DSAAT 65
A ++A V RAE L+E +GG G G + G + AA
Sbjct: 1173 AERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAAL 1232
Query: 66 NMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEE---------------SQGGK 110
E + E + L E+V L+++++ L K+ E ++
Sbjct: 1233 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 1292
Query: 111 SSEVLSAT------ELRVQLAQKEQELARA---KEALQAMKADRKRLKGEKTDLVSQMQQ 161
S+E L T E ++++ + +++LA A + LQ + RL EK L+SQ+ +
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 162 LYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE-------KWELRRQAKE 214
A E+LR + + + AV+AL + DLL + + EL+R +
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1412
Query: 215 ATDHATALRSQLDLKDNRMKELEAELAMAKQSLA 248
A RS+ + + E EL AK+ LA
Sbjct: 1413 ANAEVAQWRSKYEADAIQRTE---ELEEAKKKLA 1443
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/163 (23%), Positives = 74/163 (45%), Gaps = 11/163 (6%)
Query: 92 LRQMKEMLAKDLEESQGGKSS-----EVLSATELRVQLAQKEQ--ELARAKEALQAMKAD 144
L + K+ LA L+E++ G + L +LR+Q ++ EL RA A A+
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 145 RKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE 204
++ L+ + Q +++ LE+ + + R + R E+A++AL + L+RE
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL----ETLKRE 1550
Query: 205 KWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
L+ + + TD + + + K LE E + + +L
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL 1593
Score = 40.8 bits (94), Expect = 0.002
Identities = 64/234 (27%), Positives = 102/234 (43%), Gaps = 73/234 (31%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATE-------------LRVQL 124
L+EE+S L ++V L + + L K + +G KS E+ +A E LR+QL
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKS-EIQAALEEAEGALELEETKTLRIQL 1612
Query: 125 -------------AQKEQELA-------RAKEALQA-MKAD----------RKRLKGEKT 153
A+K++E A RA E+LQA + A+ +K+++G+
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1672
Query: 154 DLVSQMQQLYATLESREEQLRDFI-----------RNYEQH-RKESEDAVKALAKEKDLL 201
DL ++Q +AT ++ E Q + R+ EQ E + +AL + LL
Sbjct: 1673 DL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730
Query: 202 EREKWELR--------------RQAKEATDHATALRSQLDLKDNRMKELEAELA 241
E ELR ++ EAT+ L SQ N+ K+LEA+LA
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Score = 39.3 bits (90), Expect = 0.007
Identities = 44/185 (23%), Positives = 79/185 (42%), Gaps = 38/185 (20%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
A L ++ L+ + R+ +E + ++LE +Q + S L R++ +E
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRELEAAQ--RESRGLGTELFRLRHGHEE----- 1539
Query: 134 AKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKA 193
A EAL+ +K + K L+ E +DL Q+ S +++
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSL-------------------------SGKSIQE 1574
Query: 194 LAKEKDLLEREKWELRRQAKEA-----TDHATALRSQLDLKDNRMKELEAELAMAKQSLA 248
L K K LE EK E++ +EA + LR QL+L + E++ +LA + A
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK-AEVDRKLAEKDEECA 1633
Query: 249 TLTKD 253
L ++
Sbjct: 1634 NLRRN 1638
Score = 37.4 bits (85), Expect = 0.026
Identities = 58/260 (22%), Positives = 114/260 (43%), Gaps = 34/260 (13%)
Query: 3 EDNKQLALRIDGA---VQSASQEVTNL-RAEL---TATNRRLAELSGGGGPGPGPGAAAS 55
E K+LALR+ A V++A+ + ++L +A+L T + EL A S
Sbjct: 1437 EAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE----------RATS 1486
Query: 56 ASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL 115
A+AA D ++E A R + +Q E+ ++ L +L + G E L
Sbjct: 1487 AAAALDKKQRHLER----ALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE-EAL 1541
Query: 116 SATE--------LRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
A E L+ +++ +++ + +++Q ++ +K L+GEK+++ + +++ LE
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ-L 226
E + Q + E + + +E L R + + D T R++ L
Sbjct: 1602 LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL 1661
Query: 227 DLK---DNRMKELEAELAMA 243
LK + + +LE +L A
Sbjct: 1662 RLKKKMEGDLNDLELQLGHA 1681
Score = 35.8 bits (81), Expect = 0.075
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQ------------GGKSSEVLSATELRVQL 124
++ EE+ + Q+ L +MK+ L + + E Q GGK ++R
Sbjct: 1813 MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE 1872
Query: 125 AQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
A+ + E + EAL+ ++ +R+K E + ++ A ++ ++L+ +++Y++
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVK-ELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1931
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
+E+E + + E + +A A A LR++
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972
Score = 31.2 bits (69), Expect = 1.8
Identities = 43/182 (23%), Positives = 75/182 (41%), Gaps = 18/182 (9%)
Query: 83 SRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMK 142
S L V LR ++L + EE E + EL+ L++ E+A+ + +A
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEE-------EAEAQAELQRLLSKANAEVAQWRSKYEADA 1428
Query: 143 ADR-KRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESED----------AV 191
R + L+ K L ++Q+ +E+ + + + + ESED A
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAA 1488
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLT 251
AL K++ LER E RRQ +E A + + + L A ++L TL
Sbjct: 1489 AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548
Query: 252 KD 253
++
Sbjct: 1549 RE 1550
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 55.8 bits (133), Expect = 7e-08
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 16/187 (8%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKE 136
L REE R +E+ R+ E + DL + +++ EL++QLA+KE+EL A
Sbjct: 1036 LRREEKQR--QELEKTRRKLEGDSTDLSDQIAELQAQI---AELKMQLAKKEEELQAALA 1090
Query: 137 ALQAMKADRKRLKGEKTDLVSQMQQLYATLESR-------EEQLRDFIRNYEQHRKESED 189
++ A + + +L SQ+ +L LES E+Q RD E + E ED
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 190 AVKALAKEKDLLEREKWEL----RRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQ 245
+ + A +++L + + E+ + +EA H ++ ++EL +L K+
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 246 SLATLTK 252
A L K
Sbjct: 1211 VKANLEK 1217
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/195 (21%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q++L ++ +L +E LL +L E + S + + E+ L R
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKAL 194
++ Q ++ R++L+G+ TDL Q+ +L A + + QL E+ + + V+
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL----AKKEEELQAALARVEEE 1095
Query: 195 AKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
A +K++ ++ EL Q E + + R+ + + + ++L EL K L
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 255 PKRHSLAMPGETVLN 269
+ L E +N
Sbjct: 1156 AAQQELRSKREQEVN 1170
Score = 45.4 bits (106), Expect = 9e-05
Identities = 40/172 (23%), Positives = 81/172 (47%), Gaps = 8/172 (4%)
Query: 66 NMENPQLGAQVLLREEVSRLQEEVH--LLRQMKEMLAKDLEESQGG-KSSEVLSATELRV 122
N++ Q+ + L ++ E L RQ KE+ K L+E +G KS S T L
Sbjct: 1756 NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK-LQEMEGTVKSKYKASITALEA 1814
Query: 123 QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQ 182
++AQ E++L + QA +R + + D++ Q+ E ++Q +Q
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 183 HRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMK 234
+++ E+A +E + +L+R+ ++AT+ A A+ ++ N+++
Sbjct: 1875 LKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 43.9 bits (102), Expect = 3e-04
Identities = 38/174 (21%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE+ +EE+ +R+ K++ A++ TE+ +Q E + +E LQ
Sbjct: 845 EEMMAKEEELVKVRE-KQLAAEN-------------RLTEMETLQSQLMAEKLQLQEQLQ 890
Query: 140 AMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKD 199
A +T+L ++ ++L A L +++++L + + E +E E+ + L EK
Sbjct: 891 A-----------ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+++ EL Q +E L+ + + ++K+LE E + + L K+
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Score = 42.4 bits (98), Expect = 8e-04
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)
Query: 59 AGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT 118
A + + QL A+ L E + LQ ++ M E L L+E ++ A
Sbjct: 849 AKEEELVKVREKQLAAENRLTE-METLQSQL-----MAEKL--QLQEQLQAETELCAEAE 900
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKR----LKGEKTDLVSQMQQLYATLESREEQLR 174
ELR +L K+QEL L+A + + L+ EK + +Q+L LE E +
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 175 DF----------IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRS 224
++ E+ + ED LAKEK LLE E E + + +L
Sbjct: 961 KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 225 QLDLKDNRMKELEAELAMAKQSLATLTK 252
+ + + +LE L ++ L K
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEK 1048
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/198 (20%), Positives = 84/198 (42%), Gaps = 38/198 (19%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLA---QKEQELARA 134
L ++++ LQ ++ ++K LAK EE Q + A + + L + E +++
Sbjct: 1060 LSDQIAELQAQI---AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR------------------------- 169
+E L++ +A R + + +K DL +++ L LE
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 170 EEQLRDFIRNYEQHRKESEDAVKALAKE-------KDLLEREKWELRRQAKEATDHATAL 222
EE+ + ++ R++ AV+ LA++ K LE+ K L + E + L
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 223 RSQLDLKDNRMKELEAEL 240
+++ K++EA+L
Sbjct: 1237 LQGKGDSEHKRKKVEAQL 1254
Score = 40.0 bits (92), Expect = 0.004
Identities = 51/256 (19%), Positives = 105/256 (41%), Gaps = 41/256 (16%)
Query: 76 VLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELA--- 132
+ L+EE++ + +Q ++ LA ++ S G + + L ++AQ E+EL
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 133 --------RAKEA-----------------LQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
R K+A Q + R++L+ + +L ++Q++ T++
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 168 SR--------EEQLRDFIRNYEQHRKESEDAVKAL----AKEKDLLEREKWELRRQAKEA 215
S+ E ++ + KE + A K + K KD+L + E RR A++
Sbjct: 1803 SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE-RRNAEQY 1861
Query: 216 TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWV 275
D A ++L +++E E E A S L +++ A ++ + +
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Query: 276 VQADLPLTAAIRQSQQ 291
+ DLP R +++
Sbjct: 1922 RRGDLPFVVPRRMARK 1937
Score = 38.1 bits (87), Expect = 0.015
Identities = 58/268 (21%), Positives = 112/268 (41%), Gaps = 42/268 (15%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
+++G S ++ L+A++ +LA+ AA A ++A NM
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEE-------ELQAALARVEEEAAQKNMALK 1104
Query: 71 QLGAQVLLREEVSRLQEEVHLLRQMK--------------EMLAKDLEESQGGKSS--EV 114
++ L ++S LQE++ R + E L +LE++ ++ E+
Sbjct: 1105 KIRE---LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 115 LSATELRVQLAQKE-QELARAKEA-LQAMKADRKRLKGEKTDLVSQMQQLYA-------T 165
S E V + +K +E A+ EA +Q M+ + E + + Q +++ A T
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE+ +L + ++ Q + +SE K + + L+ + E R E D T L+ +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKD 253
LD + L+ + + LTKD
Sbjct: 1282 LD-------NVTGLLSQSDSKSSKLTKD 1302
Score = 36.2 bits (82), Expect = 0.057
Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 28/191 (14%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
E ++L+ EV+L + MK +DL QG +L Q+ + E EL ++
Sbjct: 1552 EDAKLRLEVNL-QAMKAQFERDL---QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 141 MKADRKRLKGEKTDL--------------VSQMQQLYATLESREEQLRDFIRNYEQ---H 183
A RK+L+ + DL + Q+++L A ++ +L D + E+
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 184 RKESEDAVKA-------LAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKEL 236
KE+E +K+ L +E ER K + +++ E D + L + L
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 237 EAELAMAKQSL 247
EA +A ++ L
Sbjct: 1728 EARIAQLEEEL 1738
Score = 34.7 bits (78), Expect = 0.17
Identities = 43/194 (22%), Positives = 86/194 (44%), Gaps = 12/194 (6%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKE-QELARAKE 136
L ++V++LQ E L + +L++ +S+ K ++ SA E ++Q Q+ QE R K
Sbjct: 1271 LADKVTKLQVE---LDNVTGLLSQS--DSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 137 ALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAK 196
+L K+++ EK Q+++ + E+Q+ +K+ ED+V L
Sbjct: 1326 SLSTKL---KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 197 EKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE---AELAMAKQSLATLTKD 253
+++ + + +L ++ + A K +EL+ +L +QS L K
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 254 VPKRHSLAMPGETV 267
K L +T+
Sbjct: 1443 QKKFDQLLAEEKTI 1456
Score = 32.7 bits (73), Expect = 0.63
Identities = 37/197 (18%), Positives = 84/197 (42%), Gaps = 23/197 (11%)
Query: 80 EEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQ 139
EE++ E+ ++ E + LE +G ++EV + + K +++ + LQ
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 140 AMKADRKRLKGEKTDLVSQMQ---------------------QLYATLESREEQLRDFIR 178
+ +R++ E D V+++Q + ++ LES+ + ++ ++
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 179 NYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATA-LRSQLDLKDNRMKELE 237
+ + +K + EK+ RE+ E +AK + A L +Q+ +M++
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSF-REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 238 AELAMAKQSLATLTKDV 254
L A++ L KD+
Sbjct: 1378 GCLETAEEVKRKLQKDL 1394
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 55.8 bits (133), Expect = 7e-08
Identities = 47/161 (29%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKG-------EKTDLVSQMQQL 162
K +L + E ++A ++E R KEAL+ +A RK L+ EK DL Q+Q
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 163 YATLESREEQLRDFIRNYEQ---------HRKESEDAVKA-LAKEKDLLEREKWELRRQA 212
L EE+ I+N Q R E E+ + A L +K LE E EL+R
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 213 KEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKD 253
+ + + +N++K L E+A + +A LTK+
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Score = 44.3 bits (103), Expect = 2e-04
Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 27/179 (15%)
Query: 85 LQEEVHLLRQMK-EMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKA 143
+Q E++ R+ + + + +DLEE+ +A LR + A EL + LQ +K
Sbjct: 1159 VQIEMNKKREAEFQKMRRDLEEAT---LQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1215
Query: 144 ----DRKRLKGEKTDLVSQMQQLY---ATLESREEQLRDFIRNYEQHRKESEDAVKALAK 196
++ K E D+ S M+Q+ A LE L D + + +E++ +V L
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1275
Query: 197 EKDLLEREKWELRRQAKEATDHATALRSQL------------DLKDNRMKELEAELAMA 243
++ L+ E EL RQ D AL SQL DLK +E++A+ A+A
Sbjct: 1276 QRAKLQTENGELSRQ----LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Score = 43.9 bits (102), Expect = 3e-04
Identities = 47/183 (25%), Positives = 84/183 (45%), Gaps = 11/183 (6%)
Query: 63 AATNMENPQLGAQVLLREE-VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELR 121
A EN +L Q+ +E +S+L Q E L + LEE K+ A
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN-----ALAHA 1332
Query: 122 VQLAQKEQELARAK-EALQAMKADRKRLKGEKTDLVSQMQQLYAT-LESREEQLRDFIRN 179
+Q A+ + +L R + E KA+ +R+ + V+Q + Y T R E+L + +
Sbjct: 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392
Query: 180 YEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEA---TDHATALRSQLDLKDNRMKEL 236
Q +E+E+AV+A+ + LE+ K L+ + ++ + + A + LD K ++
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 237 EAE 239
AE
Sbjct: 1453 LAE 1455
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/157 (22%), Positives = 65/157 (41%), Gaps = 8/157 (5%)
Query: 104 EESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLY 163
EESQ S A L +L + + + E L+ K + K L+ E +DL Q+
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1520
Query: 164 ATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWEL--------RRQAKEA 215
T+ E+ + + + E+A +L E+ + R + E R+ A++
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1580
Query: 216 TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTK 252
+ A R+ L + D+ L+AE ++L K
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617
Score = 40.0 bits (92), Expect = 0.004
Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 38/198 (19%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT-------ELRVQLAQKEQ 129
LLRE+ +EE +++ +L+K E ++ A E + +LAQ+ Q
Sbjct: 1342 LLREQY---EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 130 ELARAKEALQA----MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF---IRNYEQ 182
E A EA+ A ++ + RL+ E DL+ +++ A + +++ R+F + ++Q
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Query: 183 HRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ--------LDLKDNR-- 232
+ES+ +++ KE L E ++L+ +E+ +H + + DL +
Sbjct: 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Query: 233 -----------MKELEAE 239
K+LEAE
Sbjct: 1519 SGKTIHELEKVRKQLEAE 1536
Score = 35.4 bits (80), Expect = 0.098
Identities = 33/182 (18%), Positives = 76/182 (41%), Gaps = 4/182 (2%)
Query: 67 MENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQ 126
+E + + L + VS LQE+ L Q++ +L +++ + + +L ++ +
Sbjct: 863 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-QDNLADAEERCDQLIKNKIQLEAKVKE 921
Query: 127 KEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATL---ESREEQLRDFIRNYEQH 183
+ L +E + A +++L+ E ++L + L TL E + + ++N +
Sbjct: 922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 184 RKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMA 243
++ + L KEK L+ + + D L + ++ +LE L
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE 1041
Query: 244 KQ 245
K+
Sbjct: 1042 KK 1043
Score = 35.0 bits (79), Expect = 0.13
Identities = 39/176 (22%), Positives = 74/176 (42%), Gaps = 8/176 (4%)
Query: 71 QLGAQVLLREEVSRLQEEVHL---LRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQK 127
QL A+V +E RL++E + L K L + E + L+ ++ +
Sbjct: 914 QLEAKV--KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 128 EQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKES 187
E ++ E + + +L EK L QQ L++ E+++ + + ++
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 188 EDAVKALAKEKDL---LEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL 240
+D +L +EK + LER K +L K + L + D R+K+ + EL
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Score = 31.6 bits (70), Expect = 1.4
Identities = 29/157 (18%), Positives = 73/157 (46%), Gaps = 4/157 (2%)
Query: 98 MLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKE-ALQAMKADRKRLKGEKTDLV 156
M+A++L++ Q + + + + L A++ AL+ K ++L+ +L
Sbjct: 1764 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1823
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWEL---RRQAK 213
++++ + +R R ++ ++E+ K L + +DL+++ + ++ +RQA+
Sbjct: 1824 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1883
Query: 214 EATDHATALRSQLDLKDNRMKELEAELAMAKQSLATL 250
EA + A S+ + + E E +A+ + L
Sbjct: 1884 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2394
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2627
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1786
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1967 LEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1497 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1550 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1594
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1452 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1621
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1680
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLA 1701
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1676
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1731
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1788
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1789 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1820
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1671 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1974 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2091 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 241 AMAKQS 246
A Q+
Sbjct: 2147 ARRAQA 2152
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2441
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2127 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2229
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2230 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML 2312
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2049 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2106
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2107 SRRQVEEAERLKQS 2120
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 557
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 558 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2398
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2631
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1790
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1971 LEAARQRQLAAE 1982
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1382 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1501 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1554 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1598
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1456 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1625
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1684
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1685 EQAVRQRELA--EQELEKQRQLA 1705
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1680
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1735
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1792
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1793 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1824
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1675 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1978 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2095 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 241 AMAKQS 246
A Q+
Sbjct: 2151 ARRAQA 2156
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2445
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2131 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2233
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2234 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKML 2316
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2052
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2053 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2110
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2111 SRRQVEEAERLKQS 2124
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 508 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 561
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 562 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 621
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 622 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 680
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2394
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2627
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1786
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1967 LEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1378 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1497 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1550 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1594
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1452 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1621
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1680
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1681 EQAVRQRELA--EQELEKQRQLA 1701
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1676
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1731
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1788
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1789 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1820
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1671 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1974 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2091 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 241 AMAKQS 246
A Q+
Sbjct: 2147 ARRAQA 2152
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2441
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2127 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2229
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2230 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML 2312
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2049 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2106
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2107 SRRQVEEAERLKQS 2120
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 557
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 558 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 676
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2362
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2595
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1754
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1935 LEAARQRQLAAE 1946
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1346 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1465 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1518 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1562
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1420 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1589
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1648
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1649 EQAVRQRELA--EQELEKQRQLA 1669
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1644
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1699
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1756
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1757 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1788
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1639 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1942 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2059 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 241 AMAKQS 246
A Q+
Sbjct: 2115 ARRAQA 2120
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2409
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2095 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2197
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2198 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKML 2280
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2016
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2017 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2074
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2075 SRRQVEEAERLKQS 2088
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 472 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 525
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 526 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 585
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 586 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 644
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2531
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2764
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1923
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 2104 LEAARQRQLAAE 2115
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1515 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1634 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1687 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1731
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1589 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1758
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1817
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1818 EQAVRQRELA--EQELEKQRQLA 1838
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1813
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1868
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1925
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1926 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1957
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1808 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 2111 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2228 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 241 AMAKQS 246
A Q+
Sbjct: 2284 ARRAQA 2289
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2578
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2264 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2366
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2367 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKML 2449
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2185
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2186 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2243
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2244 SRRQVEEAERLKQS 2257
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 641 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 694
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 754
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 755 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 813
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2372
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2605
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2643
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1764
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1945 LEAARQRQLAAE 1956
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1356 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1475 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1528 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1572
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1430 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1599
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1658
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1659 EQAVRQRELA--EQELEKQRQLA 1679
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1654
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1709
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1766
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1767 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1798
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1649 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1952 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2008
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2069 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 241 AMAKQS 246
A Q+
Sbjct: 2125 ARRAQA 2130
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2419
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2105 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2207
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2208 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKML 2290
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1973 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1967 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2026
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2027 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2084
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2085 SRRQVEEAERLKQS 2098
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 482 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 535
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 536 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 595
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 596 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 654
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2380
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2613
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2651
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1772
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1953 LEAARQRQLAAE 1964
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1364 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1483 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1536 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1580
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1438 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1607
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1666
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1667 EQAVRQRELA--EQELEKQRQLA 1687
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1662
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1717
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1774
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1775 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1806
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1657 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1715
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 1960 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2016
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2077 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 241 AMAKQS 246
A Q+
Sbjct: 2133 ARRAQA 2138
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2427
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2113 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2215
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2216 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKML 2298
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 1981 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 1975 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2034
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2035 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2092
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2093 SRRQVEEAERLKQS 2106
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 490 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 543
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 544 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 603
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 604 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 662
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.5 bits (132), Expect = 9e-08
Identities = 65/338 (19%), Positives = 138/338 (40%), Gaps = 35/338 (10%)
Query: 1 MMEDNKQLALRI-------DGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAA 53
+ ED +Q+A ++ +++ Q + AE R+AE+S
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS-----------R 2421
Query: 54 ASASAAGDSAATNMENPQLGAQV----LLREEVSRLQEEVHLLRQMKEMLAKDLEES--Q 107
A A A D+ + ++G ++ L +E L + + + RQ + A+ L E+ +
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 108 GGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLE 167
+ E L +QL +E + + ++ LQ +A ++ EK L+ + + +
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 168 SREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
E+ +D + +Q R+E + + + +E+ L E RR+ EA + + +L
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 228 LKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIR 287
+ + ++ E LA Q L + + ++H A+ + E V + + T +
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-------AHSEEVTASQVAATKTLP 2654
Query: 288 QSQQTL----YHSHPPHPADRQAVRVSPCHSRQPSVIS 321
+ L + P H D +VS ++ ++S
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2692
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 11 RIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENP 70
R+ +A+Q+ L AEL + L A+ A A +S +T+ ++
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVL-----------LASKARAEEESRSTSEKSK 1813
Query: 71 Q-----LGAQVLLREEVSRLQ---EEVHLLRQMKEMLAKDLEESQGGKSSEVLSA----- 117
Q G L EE +RL+ EE RQ+ E A +E L+A
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 118 ---TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVSQMQQLYATLESRE 170
TE + L +KE E R + + R+RL+ + K D+ ++ QL +S
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 171 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA-TALRS--QLD 227
E+ + + + + R++ E+ + AL + K EL + +A LRS Q +
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 228 LKDNRMKELEAE 239
L+ R ++L AE
Sbjct: 1994 LEAARQRQLAAE 2005
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/226 (25%), Positives = 99/226 (43%), Gaps = 30/226 (13%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVS--------RLQEEVHLLRQMKEM-LAKD 102
A A A A + A ++ ++ +V+ REE + +QEE+ LRQ E +
Sbjct: 1405 AHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 103 LEESQGGKSSEVLSATELRV---QLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM 159
+++ + S + E+RV QL E++ A+ LQA++A + + +K +
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523
Query: 160 QQLYATLESREEQLRDFIRNYEQHRKESEDAVKA---LAKEKDLLEREKWELRRQAKEA- 215
++L Q++D + Q E VKA A+EK + ELR QA+EA
Sbjct: 1524 ERL-------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 216 -----TDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPK 256
+ A + Q+ L + + EAEL + S A T + +
Sbjct: 1577 RRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLER 1621
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 35/263 (13%)
Query: 21 QEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLRE 80
+E+ +R +L AT R+ GG G A A A E + + + E
Sbjct: 1479 EEIRVVRLQLEATERQR-----GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVL--SATELRVQLAQKEQELARAKE-A 137
+ Q EV L ++K E+ + ++ E L A E +L Q E E AR + A
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 138 LQ-AMKADRKRLKGEKTDLVSQMQQLYATLESRE---EQLRDFIRNYEQHRKESEDAVKA 193
L+ A ++ L+ ++ + QL +L+ QLR+ E R+ + A
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE-----EAERRAQQQAEAE 1648
Query: 194 LAKEKDLLEREKWE--------LRRQAKEATDHATALRSQLDLKDNRMKELEA------- 238
A+E+ E E+W+ LR QA+E + +++ + K E EA
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAE 1707
Query: 239 ELAMAKQSLATLTKDVPKRHSLA 261
E A+ ++ LA +++ K+ LA
Sbjct: 1708 EQAVRQRELA--EQELEKQRQLA 1728
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 54 ASASAAGDSAATNMENPQLGAQVLLR-----EEVSRLQEEVHLLRQMKEMLAKDLEESQG 108
A A A + A +E QL A LR EEV++ Q+ + K+ + E +
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQKEEAEREARRR 1703
Query: 109 GKSSE-VLSATELRVQLAQKEQELARAKEALQAMKADRK--RLKGEKTDLVSQMQQLYAT 165
GK+ E + EL Q +K+++LA A Q + A+++ RL+ E T+ Q +QL
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGT-AQQRLAAEQELIRLRAE-TEQGEQQRQL--- 1758
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQ 225
LE +L+ Q R+E E + + E ++L K +++ ++ + + +
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---KQR 1815
Query: 226 LDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
L+ + R +EL E A L L ++ ++ LA
Sbjct: 1816 LEAEAGRFRELAEEAA----RLRALAEEAKRQRQLA 1847
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 79 REEVSRLQEEVHLLRQMKEMLAKDLEESQG---GKSSEVLSATE----LRVQLAQKEQ-- 129
RE R + E +RQ +E+ ++LE+ + G + + L+A + LR + Q EQ
Sbjct: 1698 REARRRGKAEEQAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1756
Query: 130 -----ELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHR 184
ELAR + A R+ L+ E + ++M+ L A+ EE+ R +Q
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLD 227
+ + LA+E L E +RQ + A + A R++ +
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Q+ EE R + E R K + A++ Q + E + + +V+ A++ +E A
Sbjct: 2001 QLAAEEERRRREAEE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2057
Query: 135 KEALQ---AMKADRKRLKGEKTDLVSQMQQ----LYATLESREEQLRDFIRNYEQHRKES 187
+ A Q A +A +KRL+ E+ +QQ L TL+ + L E R+ +
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Query: 188 EDAVKALAKEKDLLEREKWELRRQAKEA------TDHATALRSQLDLKDNRM-KELEAEL 240
E+A +A + ERE + RRQ +EA + R+Q ++ KE E E
Sbjct: 2118 EEAEEARVQA----EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 241 AMAKQS 246
A Q+
Sbjct: 2174 ARRAQA 2179
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/178 (21%), Positives = 77/178 (43%), Gaps = 5/178 (2%)
Query: 85 LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA---M 141
LQEE ++Q+ E A+ +Q L+ +L Q A E+ L +A+Q +
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 142 KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLL 201
KA+ + L+ +K Q ++L E +QL + + +++ + ++ E + L
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 202 EREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHS 259
+ E+ R A + A R Q + ++ ELA ++ T ++ ++ S
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQS 2468
Score = 39.3 bits (90), Expect = 0.007
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 30/206 (14%)
Query: 52 AAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMK------EMLAKDLEE 105
A A A AA + E +E R Q E LRQ + E K E+
Sbjct: 2154 ARAQAQAAAEKLRKEAE----------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 106 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYAT 165
+ K+ T LR+QL + + + E LQ RLK E T+ Q Q+
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQRSQVEEE 2256
Query: 166 LESREEQLRDFIRNYEQHRKESEDAVKALAKEKD----LLEREKWELRRQAKEATDHATA 221
L S Q+ + + + R E+E+ L ++KD L+ E ++++ A+EA + A
Sbjct: 2257 LFSVRVQMEELSK--LKARIEAENRALIL-RDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 222 LRSQLDLKDNRMKELEAELAMAKQSL 247
+ L+ ++L + A+A++ L
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKML 2339
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 33/222 (14%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRL-----QEEVHLLRQMKEMLAKDLEESQ 107
AA AA A E +L A+V EE RL QE L+ +E K L+ +
Sbjct: 2022 AAEEEAARQRKAALEEVERLKAKV---EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Query: 108 GGKSSEVLSATELRVQLAQKEQELA-----------RAKEALQAMKADRKRLKGEKTDLV 156
+ V + Q Q+EQ + RA E + + +R + V
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Query: 157 SQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKW---------- 206
+ ++L + E + + E+ RKE+E A+ + R+K
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 207 ----ELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
+ RQ + T LR QL+ D++ L+ EL K
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240
Score = 33.5 bits (75), Expect = 0.37
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 5/194 (2%)
Query: 53 AASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSS 112
A+ AA A +E ++ + E+ R +E+ L + LA + E +
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
Query: 113 EVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQ 172
V + + A++ + E L+A + +RL+ ++ QL + Q
Sbjct: 2016 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2075
Query: 173 LRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNR 232
+ + +KE E + L +E+ +L++ + E A+ A + A R Q + + +
Sbjct: 2076 AEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQ 2133
Query: 233 MKELEAELAMAKQS 246
+ E KQS
Sbjct: 2134 SRRQVEEAERLKQS 2147
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/179 (22%), Positives = 82/179 (45%), Gaps = 21/179 (11%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR 133
AQV L+ R + E LR ++++LA +EE+Q + E V L E +L
Sbjct: 531 AQVTLQSVQRRPELEDSTLRYLQDLLAW-VEENQ-----HRVDGAEWGVDLPSVEAQLGS 584
Query: 134 AK---EALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDA 190
+ ++++ +A +R + ++ L + Y R + + N + R S ++
Sbjct: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 644
Query: 191 VKAL--AKEKDLL---EREKWELRRQAKEATDHATA-------LRSQLDLKDNRMKELE 237
+ + A K+L+ E+E+ E+ + + TA L +L+LK+ ++KEL+
Sbjct: 645 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 703
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 55.5 bits (132), Expect = 9e-08
Identities = 72/327 (22%), Positives = 129/327 (39%), Gaps = 46/327 (14%)
Query: 58 AAGDSAATNMENPQLGAQVLLREE---VSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEV 114
AA +S +E +L Q L +E +RL+EE +Q+ ML K+ ++ G E
Sbjct: 130 AAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEE- 188
Query: 115 LSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLR 174
A +L +A+ E+E + E + + A+++R T++ +QM++ + ++ EQLR
Sbjct: 189 --AQKLEDVMAKLEEEKKKTNELEEELSAEKRR----STEMEAQMEKQLSEFDTEREQLR 242
Query: 175 DFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMK 234
+ E H + ++ + + K + Q K +D +L KD R+
Sbjct: 243 AKLNREEAHTTDLKEEIDKMRK-----------MIEQLKRGSDSKPSLSLPRKTKDRRLV 291
Query: 235 ELEA-------ELAMAKQSLATLTKDVPKRHSLAMP-----GETVLNGNQEWVV--QADL 280
+ + L T D K+ L MP G +++ N + V A +
Sbjct: 292 SISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATM 351
Query: 281 PLTAAIRQSQ--QTLYHSHP--PHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSD 336
RQ+ + S P P P+ + P P S PS+
Sbjct: 352 ARPGIDRQASYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSSTPPL-------PSN 404
Query: 337 INSPRHRTHSLCNGDSPGPVQKNLHNP 363
P +T + +S P +LH+P
Sbjct: 405 AAPPTAQTPGIAPQNSQAPPMHSLHSP 431
Score = 38.5 bits (88), Expect = 0.012
Identities = 33/151 (21%), Positives = 66/151 (43%), Gaps = 5/151 (3%)
Query: 110 KSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESR 169
K E +SA + QK+ E+ + + LQA++ + K+L + + +Q+ L
Sbjct: 120 KMQERMSAQLAAAESRQKKLEMEKLQ--LQALEQEHKKLAARLEEERGKNKQVVLMLVKE 177
Query: 170 EEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLK 229
+QL + Q + ED + L +EK + EL + + +T+ + QL
Sbjct: 178 CKQLSGKVIEEAQ---KLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEF 234
Query: 230 DNRMKELEAELAMAKQSLATLTKDVPKRHSL 260
D ++L A+L + L +++ K +
Sbjct: 235 DTEREQLRAKLNREEAHTTDLKEEIDKMRKM 265
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 55.1 bits (131), Expect = 1e-07
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 28/218 (12%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT-------ELRVQLAQ 126
A+ L E++SRLQ E + ++ E +D+ E + V A+ +L+ QL +
Sbjct: 1726 AKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE 1785
Query: 127 KEQELARAKEALQAMKADRKRLKGEKTD--LVSQMQQLYATLESREEQLRDFIRNYEQHR 184
+E +E LQA+++ + L+ D LVS+ + LE+R E R ++ E
Sbjct: 1786 ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
++ ++ L +E+D +R A E + R Q L+D KE ELA +
Sbjct: 1846 SRLKENMEKLTEERD---------QRIAAENREKEQNKRLQRQLRDT--KEEMGELARKE 1894
Query: 245 QSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPL 282
+ K+H L M E++ NQ +QADL L
Sbjct: 1895 AEASR------KKHELEMDLESLEAANQS--LQADLKL 1924
Score = 42.7 bits (99), Expect = 6e-04
Identities = 49/206 (23%), Positives = 82/206 (39%), Gaps = 30/206 (14%)
Query: 71 QLGAQVLLREEVSRLQEEVHLLRQM--KEMLAKDLEESQGGKSSEVLSATELRVQLAQK- 127
Q G +L + RL+ E+ +RQ KEM ++D EE + + S ++ VQL ++
Sbjct: 1561 QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD-EEVEEARQSCQKKLKQMEVQLEEEY 1619
Query: 128 --EQELARAKEALQA-------------------MKADRKRLKGEKTDLVSQMQQLYATL 166
+Q++ R K L+ ++ D KR K D + L +
Sbjct: 1620 EDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679
Query: 167 ESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQL 226
S+ E I + +ESE A K + +E E +L Q + TAL QL
Sbjct: 1680 PSKRE-----IAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQL 1734
Query: 227 DLKDNRMKELEAELAMAKQSLATLTK 252
E++ L ++ + L K
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMK 1760
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/211 (23%), Positives = 93/211 (44%), Gaps = 28/211 (13%)
Query: 79 REEVSR--LQEEVHLLRQMKEMLAKDLEESQ---GGKSSEVLS----ATELRVQLAQKEQ 129
RE++ R LQ E +L L + LEE G + +V+S ++ Q ++ E
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1535
Query: 130 ELARAKEALQAMKA---DRKRLKGEKTDLVSQMQQLYATLESREEQLRD-FIRNYEQHRK 185
LA+ K+ L+ ++A D++ E+ + ++Q LE E++R + E +
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595
Query: 186 ESEDAVKALAKEKDLLE-------REKWELRRQAKEATDHATALRSQLDLKD-------- 230
E E+A ++ K+ +E +K ++ R+ +E L Q++ +D
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655
Query: 231 NRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
+K +A LA A+ L L P + +A
Sbjct: 1656 KDLKRTKALLADAQLMLDHLKNSAPSKREIA 1686
Score = 40.4 bits (93), Expect = 0.003
Identities = 40/193 (20%), Positives = 83/193 (43%), Gaps = 8/193 (4%)
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIR 178
+L +L + + ++ ALQ +K +RL E D ++ E++ R F
Sbjct: 1406 QLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDS 1465
Query: 179 NYEQHRKESEDAV---KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKE 235
Q +E++ + L +EKD+L E + L++Q +E ++ + +++
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 236 LEAELAMAKQSLATLTKDVPKRHSLAMPGETVLN---GNQEWVVQADLPLTAAIRQSQQT 292
+ ++ + + SLA + K + + E L+ G + + QA L L + + +QT
Sbjct: 1526 ISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQT 1585
Query: 293 LYHSHPPHPADRQ 305
HS D +
Sbjct: 1586 --HSKEMESRDEE 1596
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 55.1 bits (131), Expect = 1e-07
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 28/218 (12%)
Query: 74 AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT-------ELRVQLAQ 126
A+ L E++SRLQ E + ++ E +D+ E + V A+ +L+ QL +
Sbjct: 1726 AKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE 1785
Query: 127 KEQELARAKEALQAMKADRKRLKGEKTD--LVSQMQQLYATLESREEQLRDFIRNYEQHR 184
+E +E LQA+++ + L+ D LVS+ + LE+R E R ++ E
Sbjct: 1786 ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 185 KESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAK 244
++ ++ L +E+D +R A E + R Q L+D KE ELA +
Sbjct: 1846 SRLKENMEKLTEERD---------QRIAAENREKEQNKRLQRQLRDT--KEEMGELARKE 1894
Query: 245 QSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPL 282
+ K+H L M E++ NQ +QADL L
Sbjct: 1895 AEASR------KKHELEMDLESLEAANQS--LQADLKL 1924
Score = 42.7 bits (99), Expect = 6e-04
Identities = 49/206 (23%), Positives = 82/206 (39%), Gaps = 30/206 (14%)
Query: 71 QLGAQVLLREEVSRLQEEVHLLRQM--KEMLAKDLEESQGGKSSEVLSATELRVQLAQK- 127
Q G +L + RL+ E+ +RQ KEM ++D EE + + S ++ VQL ++
Sbjct: 1561 QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD-EEVEEARQSCQKKLKQMEVQLEEEY 1619
Query: 128 --EQELARAKEALQA-------------------MKADRKRLKGEKTDLVSQMQQLYATL 166
+Q++ R K L+ ++ D KR K D + L +
Sbjct: 1620 EDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679
Query: 167 ESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQL 226
S+ E I + +ESE A K + +E E +L Q + TAL QL
Sbjct: 1680 PSKRE-----IAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQL 1734
Query: 227 DLKDNRMKELEAELAMAKQSLATLTK 252
E++ L ++ + L K
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMK 1760
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/211 (23%), Positives = 93/211 (44%), Gaps = 28/211 (13%)
Query: 79 REEVSR--LQEEVHLLRQMKEMLAKDLEESQ---GGKSSEVLS----ATELRVQLAQKEQ 129
RE++ R LQ E +L L + LEE G + +V+S ++ Q ++ E
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1535
Query: 130 ELARAKEALQAMKA---DRKRLKGEKTDLVSQMQQLYATLESREEQLRD-FIRNYEQHRK 185
LA+ K+ L+ ++A D++ E+ + ++Q LE E++R + E +
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595
Query: 186 ESEDAVKALAKEKDLLE-------REKWELRRQAKEATDHATALRSQLDLKD-------- 230
E E+A ++ K+ +E +K ++ R+ +E L Q++ +D
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655
Query: 231 NRMKELEAELAMAKQSLATLTKDVPKRHSLA 261
+K +A LA A+ L L P + +A
Sbjct: 1656 KDLKRTKALLADAQLMLDHLKNSAPSKREIA 1686
Score = 40.4 bits (93), Expect = 0.003
Identities = 40/193 (20%), Positives = 83/193 (43%), Gaps = 8/193 (4%)
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIR 178
+L +L + + ++ ALQ +K +RL E D ++ E++ R F
Sbjct: 1406 QLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDS 1465
Query: 179 NYEQHRKESEDAV---KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKE 235
Q +E++ + L +EKD+L E + L++Q +E ++ + +++
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 236 LEAELAMAKQSLATLTKDVPKRHSLAMPGETVLN---GNQEWVVQADLPLTAAIRQSQQT 292
+ ++ + + SLA + K + + E L+ G + + QA L L + + +QT
Sbjct: 1526 ISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQT 1585
Query: 293 LYHSHPPHPADRQ 305
HS D +
Sbjct: 1586 --HSKEMESRDEE 1596
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/256 (23%), Positives = 112/256 (43%), Gaps = 32/256 (12%)
Query: 2 MEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGD 61
+++ +Q + R G +Q ++ RA L R AEL A + G
Sbjct: 889 VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL-----------CAEAEETRGR 937
Query: 62 SAATNMENPQLGAQVLLREEVSRLQEEVHLLRQM---KEMLAKDLEESQGGKSSEVLSAT 118
AA E ++++ E +R+ EE RQM K+ L + ++E + +E +
Sbjct: 938 LAARKQE-----LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 992
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF-- 176
+L+++ E ++ + +E L ++ +L E+ L ++ + + EE+++
Sbjct: 993 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK 1052
Query: 177 --------IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDL 228
I + E ++ E + L K K L+ E EL+ Q E A LR+QL
Sbjct: 1053 LRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR 1112
Query: 229 KDNRMKELEAELAMAK 244
K+ +EL+A LA A+
Sbjct: 1113 KE---EELQAALARAE 1125
Score = 49.7 bits (117), Expect = 5e-06
Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 22/208 (10%)
Query: 76 VLLREEVSRLQEEVHLLR-QMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
+LL ++ S+L +E LL ++ E ++ EE + KS L + +A E L +
Sbjct: 1013 LLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL-KYEATIADMEDRLRKE 1071
Query: 135 KEALQAMKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLRDFIRNYE------ 181
++ Q ++ ++RL GE ++L QM ++L A L +EE+L+ + E
Sbjct: 1072 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131
Query: 182 -QHRKESEDAVKALAKEKDLLERE---KWELRRQAKEATDHATALRSQL-DLKD--NRMK 234
Q K +A ALA+ ++ LE E + + +Q ++ + ALR +L D D N +
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1191
Query: 235 ELEAELAMAKQSLATLTKDVPKRHSLAM 262
EL ++ L ++ + H A+
Sbjct: 1192 ELRSKREQEVTELKKTLEEETRIHEAAV 1219
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/259 (25%), Positives = 105/259 (40%), Gaps = 31/259 (11%)
Query: 15 AVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGA 74
A + A +E+ +A+L+ RR E +G G A AA ++ A +
Sbjct: 1383 ARERAGRELQTAQAQLSEWRRRQEEEAGA----LEAGEEARRRAAREAEALTQRLAEK-- 1436
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
E V RL+ L+Q + DLE+ + +++S E + + + +Q LA
Sbjct: 1437 ----TETVDRLERGRRRLQQELDDATMDLEQQR-----QLVSTLEKKQR--KFDQLLAEE 1485
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKAL 194
K A+ +R+R + E + ++ L LE +E + R R E E AL
Sbjct: 1486 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE----AL 1541
Query: 195 AKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
KD + + EL R + A A LR+Q + ELE EL A+ + L V
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAANDLRAQ-------VTELEDELTAAEDAKLRLEVTV 1594
Query: 255 PKRHSLAMPGETVLNGNQE 273
+L E L G E
Sbjct: 1595 ---QALKTQHERDLQGRDE 1610
Score = 46.2 bits (108), Expect = 6e-05
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 9/173 (5%)
Query: 79 REEVSR----LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
REE+ R L+ E+ L K+ + K + E + +A +LR Q+ + E EL A
Sbjct: 1524 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAA 1583
Query: 135 KEALQAMKADRKRLKGE-KTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKA 193
++A ++ + LK + + DL + + +QLRD ++ RK+ AV A
Sbjct: 1584 EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA 1643
Query: 194 LAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQS 246
K LE E EL+ Q A QL +MKEL E+ + S
Sbjct: 1644 RKK----LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Score = 44.3 bits (103), Expect = 2e-04
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 18/172 (10%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
EV LQ V L + + LA+ L ++ A E R +LA ++QEL L+A
Sbjct: 899 EVGELQGRVAQLEEERARLAEQLR----AEAELCAEAEETRGRLAARKQELELVVSELEA 954
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDL 200
GE+ + QMQ + +++L+ I+ E H + E A + L EK
Sbjct: 955 R-------VGEEEECSRQMQ-------TEKKRLQQHIQELEAHLEAEEGARQKLQLEKVT 1000
Query: 201 LEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTK 252
E + + D + L + L ++R+ E ++ A ++ + +L K
Sbjct: 1001 TEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK 1052
Score = 39.3 bits (90), Expect = 0.007
Identities = 33/140 (23%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 91 LLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR-AKEALQAMKADRKRLK 149
L RQ++E+ + EE G ++ ++ L +LAQ E++L + +E + + K R+ K
Sbjct: 1815 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1874
Query: 150 GEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKE---KDLLEREKW 206
K ++V Q+++ + +QL +Q +++ E+A + ++ + L+RE
Sbjct: 1875 RLK-EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1933
Query: 207 ELRRQAKEATDHATALRSQL 226
++ A+ T LR++L
Sbjct: 1934 DVTESAESMNREVTTLRNRL 1953
Score = 38.9 bits (89), Expect = 0.009
Identities = 49/207 (23%), Positives = 86/207 (41%), Gaps = 39/207 (18%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEA 137
L EV RLQEE+ + + +D +E ++ LS + + Q E L + +E
Sbjct: 1710 LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE 1769
Query: 138 LQAMKADRKRLKGEKTDLVSQMQQLYATL----------ESREEQLRDFIRNYEQHRKES 187
L+ +++ + L L+ Q++ L L ES +QL I+ E
Sbjct: 1770 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEE 1829
Query: 188 EDAVKA------------LAKEKDLLEREKWE-------LRR----------QAKEATDH 218
+ +A LA+ ++ LE+E E +RR Q +E
Sbjct: 1830 DAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRV 1889
Query: 219 ATALRSQLDLKDNRMKELEAELAMAKQ 245
A LR QL+ + R+K+L+ +L A++
Sbjct: 1890 ADQLRDQLEKGNLRVKQLKRQLEEAEE 1916
Score = 38.1 bits (87), Expect = 0.015
Identities = 58/270 (21%), Positives = 109/270 (40%), Gaps = 31/270 (11%)
Query: 3 EDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDS 62
++ ++L R+DG E + L+ ++ +R EL G AA A A +
Sbjct: 1076 QELEKLKRRLDG-------ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1128
Query: 63 AATNMENPQLG-AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEE---SQGGKSSEVLSAT 118
A L AQ L E L+ E + R E +DL E + G+ + L +T
Sbjct: 1129 GARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDTLDST 1187
Query: 119 ELRVQLAQK-EQELARAKEALQ--------AMKADRKRLKGEKTDLVSQMQQLYA----- 164
+ +L K EQE+ K+ L+ A++ R+R +L Q++Q
Sbjct: 1188 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1247
Query: 165 -----TLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA 219
LE+ +LR + + + R+E E + L + ++ + R EA +
Sbjct: 1248 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1307
Query: 220 TALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+++L+ + E E++ + L++
Sbjct: 1308 QRAQAELENVSGALNEAESKTIRLSKELSS 1337
Score = 37.0 bits (84), Expect = 0.034
Identities = 41/176 (23%), Positives = 80/176 (45%), Gaps = 15/176 (8%)
Query: 80 EEVSRLQEE-VHLLRQMKEM----LAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
EE +R+ E V LRQ LA+ LE+++ GK + + L ++++ EL+
Sbjct: 1209 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1268
Query: 135 KEALQAMKADRKRLKGEKTDLVSQM---QQLYATLESREEQLRDFIRNYEQHRKESEDAV 191
+ A Q + R+RL+ + ++ + ++ A + ++ + + N E+E
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
L+KE E + + + +E T AL S R++ +EAE A ++ L
Sbjct: 1329 IRLSKELSSTEAQLHDAQELLQEETRAKLALGS-------RVRAMEAEAAGLREQL 1377
Score = 34.7 bits (78), Expect = 0.17
Identities = 38/200 (19%), Positives = 77/200 (38%), Gaps = 23/200 (11%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGG------KSSEVLSATELRVQLAQKEQE 130
L R + Q++ LR M+ A L+ K +L T L + QE
Sbjct: 826 LARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 885
Query: 131 LARAKEALQAMKADRKRLKGE-----------------KTDLVSQMQQLYATLESREEQL 173
L + +E Q + L+G + +L ++ ++ L +R+++L
Sbjct: 886 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 945
Query: 174 RDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRM 233
+ E E E+ + + EK L++ EL + L+ + + +M
Sbjct: 946 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKM 1005
Query: 234 KELEAELAMAKQSLATLTKD 253
K+ E +L + + + L+K+
Sbjct: 1006 KKFEEDLLLLEDQNSKLSKE 1025
Score = 33.9 bits (76), Expect = 0.28
Identities = 56/295 (18%), Positives = 116/295 (39%), Gaps = 43/295 (14%)
Query: 12 IDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQ 71
++ A + A Q +LRA++T L A + A +E
Sbjct: 1555 LERACRVAEQAANDLRAQVTELEDELT--------------------AAEDAKLRLE--- 1591
Query: 72 LGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT------------- 118
+ Q L + LQ + + LAK L +++ + E T
Sbjct: 1592 VTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL 1651
Query: 119 -ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
EL+ Q+A Q A + L+ M+A K L E + + +++++ ++RE + R +
Sbjct: 1652 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS--QNRESEKR--L 1707
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE 237
+ E ++ + A + + ++++ E+ + A+ + + R+ +LE
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1767
Query: 238 AELAMAKQSLATLTKDVPKRHSLAMPG-ETVLNGNQEWVVQADLPLTAAIRQSQQ 291
EL +QS + L D ++ L + T L+ + + +A+ RQ Q+
Sbjct: 1768 EELE-EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1821
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/256 (23%), Positives = 112/256 (43%), Gaps = 32/256 (12%)
Query: 2 MEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGD 61
+++ +Q + R G +Q ++ RA L R AEL A + G
Sbjct: 881 VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL-----------CAEAEETRGR 929
Query: 62 SAATNMENPQLGAQVLLREEVSRLQEEVHLLRQM---KEMLAKDLEESQGGKSSEVLSAT 118
AA E ++++ E +R+ EE RQM K+ L + ++E + +E +
Sbjct: 930 LAARKQE-----LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 984
Query: 119 ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDF-- 176
+L+++ E ++ + +E L ++ +L E+ L ++ + + EE+++
Sbjct: 985 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK 1044
Query: 177 --------IRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDL 228
I + E ++ E + L K K L+ E EL+ Q E A LR+QL
Sbjct: 1045 LRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR 1104
Query: 229 KDNRMKELEAELAMAK 244
K+ +EL+A LA A+
Sbjct: 1105 KE---EELQAALARAE 1117
Score = 49.7 bits (117), Expect = 5e-06
Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 22/208 (10%)
Query: 76 VLLREEVSRLQEEVHLLR-QMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
+LL ++ S+L +E LL ++ E ++ EE + KS L + +A E L +
Sbjct: 1005 LLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL-KYEATIADMEDRLRKE 1063
Query: 135 KEALQAMKADRKRLKGEKTDLVSQM-------QQLYATLESREEQLRDFIRNYE------ 181
++ Q ++ ++RL GE ++L QM ++L A L +EE+L+ + E
Sbjct: 1064 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1123
Query: 182 -QHRKESEDAVKALAKEKDLLERE---KWELRRQAKEATDHATALRSQL-DLKD--NRMK 234
Q K +A ALA+ ++ LE E + + +Q ++ + ALR +L D D N +
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1183
Query: 235 ELEAELAMAKQSLATLTKDVPKRHSLAM 262
EL ++ L ++ + H A+
Sbjct: 1184 ELRSKREQEVTELKKTLEEETRIHEAAV 1211
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/259 (25%), Positives = 105/259 (40%), Gaps = 31/259 (11%)
Query: 15 AVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGA 74
A + A +E+ +A+L+ RR E +G G A AA ++ A +
Sbjct: 1375 ARERAGRELQTAQAQLSEWRRRQEEEAGA----LEAGEEARRRAAREAEALTQRLAEK-- 1428
Query: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
E V RL+ L+Q + DLE+ + +++S E + + + +Q LA
Sbjct: 1429 ----TETVDRLERGRRRLQQELDDATMDLEQQR-----QLVSTLEKKQR--KFDQLLAEE 1477
Query: 135 KEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKAL 194
K A+ +R+R + E + ++ L LE +E + R R E E AL
Sbjct: 1478 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE----AL 1533
Query: 195 AKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDV 254
KD + + EL R + A A LR+Q + ELE EL A+ + L V
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAANDLRAQ-------VTELEDELTAAEDAKLRLEVTV 1586
Query: 255 PKRHSLAMPGETVLNGNQE 273
+L E L G E
Sbjct: 1587 ---QALKTQHERDLQGRDE 1602
Score = 46.2 bits (108), Expect = 6e-05
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 9/173 (5%)
Query: 79 REEVSR----LQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
REE+ R L+ E+ L K+ + K + E + +A +LR Q+ + E EL A
Sbjct: 1516 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAA 1575
Query: 135 KEALQAMKADRKRLKGE-KTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKA 193
++A ++ + LK + + DL + + +QLRD ++ RK+ AV A
Sbjct: 1576 EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA 1635
Query: 194 LAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQS 246
K LE E EL+ Q A QL +MKEL E+ + S
Sbjct: 1636 RKK----LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Score = 44.3 bits (103), Expect = 2e-04
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 18/172 (10%)
Query: 81 EVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQA 140
EV LQ V L + + LA+ L ++ A E R +LA ++QEL L+A
Sbjct: 891 EVGELQGRVAQLEEERARLAEQLR----AEAELCAEAEETRGRLAARKQELELVVSELEA 946
Query: 141 MKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDL 200
GE+ + QMQ + +++L+ I+ E H + E A + L EK
Sbjct: 947 R-------VGEEEECSRQMQ-------TEKKRLQQHIQELEAHLEAEEGARQKLQLEKVT 992
Query: 201 LEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTK 252
E + + D + L + L ++R+ E ++ A ++ + +L K
Sbjct: 993 TEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK 1044
Score = 39.3 bits (90), Expect = 0.007
Identities = 33/140 (23%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 91 LLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELAR-AKEALQAMKADRKRLK 149
L RQ++E+ + EE G ++ ++ L +LAQ E++L + +E + + K R+ K
Sbjct: 1807 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1866
Query: 150 GEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKE---KDLLEREKW 206
K ++V Q+++ + +QL +Q +++ E+A + ++ + L+RE
Sbjct: 1867 RLK-EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1925
Query: 207 ELRRQAKEATDHATALRSQL 226
++ A+ T LR++L
Sbjct: 1926 DVTESAESMNREVTTLRNRL 1945
Score = 38.9 bits (89), Expect = 0.009
Identities = 49/207 (23%), Positives = 86/207 (41%), Gaps = 39/207 (18%)
Query: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEA 137
L EV RLQEE+ + + +D +E ++ LS + + Q E L + +E
Sbjct: 1702 LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE 1761
Query: 138 LQAMKADRKRLKGEKTDLVSQMQQLYATL----------ESREEQLRDFIRNYEQHRKES 187
L+ +++ + L L+ Q++ L L ES +QL I+ E
Sbjct: 1762 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEE 1821
Query: 188 EDAVKA------------LAKEKDLLEREKWE-------LRR----------QAKEATDH 218
+ +A LA+ ++ LE+E E +RR Q +E
Sbjct: 1822 DAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRV 1881
Query: 219 ATALRSQLDLKDNRMKELEAELAMAKQ 245
A LR QL+ + R+K+L+ +L A++
Sbjct: 1882 ADQLRDQLEKGNLRVKQLKRQLEEAEE 1908
Score = 38.1 bits (87), Expect = 0.015
Identities = 58/270 (21%), Positives = 109/270 (40%), Gaps = 31/270 (11%)
Query: 3 EDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDS 62
++ ++L R+DG E + L+ ++ +R EL G AA A A +
Sbjct: 1068 QELEKLKRRLDG-------ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1120
Query: 63 AATNMENPQLG-AQVLLREEVSRLQEEVHLLRQMKEMLAKDLEE---SQGGKSSEVLSAT 118
A L AQ L E L+ E + R E +DL E + G+ + L +T
Sbjct: 1121 GARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDTLDST 1179
Query: 119 ELRVQLAQK-EQELARAKEALQ--------AMKADRKRLKGEKTDLVSQMQQLYA----- 164
+ +L K EQE+ K+ L+ A++ R+R +L Q++Q
Sbjct: 1180 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1239
Query: 165 -----TLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHA 219
LE+ +LR + + + R+E E + L + ++ + R EA +
Sbjct: 1240 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1299
Query: 220 TALRSQLDLKDNRMKELEAELAMAKQSLAT 249
+++L+ + E E++ + L++
Sbjct: 1300 QRAQAELENVSGALNEAESKTIRLSKELSS 1329
Score = 37.0 bits (84), Expect = 0.034
Identities = 41/176 (23%), Positives = 80/176 (45%), Gaps = 15/176 (8%)
Query: 80 EEVSRLQEE-VHLLRQMKEM----LAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
EE +R+ E V LRQ LA+ LE+++ GK + + L ++++ EL+
Sbjct: 1201 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1260
Query: 135 KEALQAMKADRKRLKGEKTDLVSQM---QQLYATLESREEQLRDFIRNYEQHRKESEDAV 191
+ A Q + R+RL+ + ++ + ++ A + ++ + + N E+E
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Query: 192 KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSL 247
L+KE E + + + +E T AL S R++ +EAE A ++ L
Sbjct: 1321 IRLSKELSSTEAQLHDAQELLQEETRAKLALGS-------RVRAMEAEAAGLREQL 1369
Score = 34.7 bits (78), Expect = 0.17
Identities = 38/200 (19%), Positives = 77/200 (38%), Gaps = 23/200 (11%)
Query: 77 LLREEVSRLQEEVHLLRQMKEMLAKDLEESQGG------KSSEVLSATELRVQLAQKEQE 130
L R + Q++ LR M+ A L+ K +L T L + QE
Sbjct: 818 LARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 877
Query: 131 LARAKEALQAMKADRKRLKGE-----------------KTDLVSQMQQLYATLESREEQL 173
L + +E Q + L+G + +L ++ ++ L +R+++L
Sbjct: 878 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 937
Query: 174 RDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRM 233
+ E E E+ + + EK L++ EL + L+ + + +M
Sbjct: 938 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKM 997
Query: 234 KELEAELAMAKQSLATLTKD 253
K+ E +L + + + L+K+
Sbjct: 998 KKFEEDLLLLEDQNSKLSKE 1017
Score = 33.9 bits (76), Expect = 0.28
Identities = 56/295 (18%), Positives = 116/295 (39%), Gaps = 43/295 (14%)
Query: 12 IDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQ 71
++ A + A Q +LRA++T L A + A +E
Sbjct: 1547 LERACRVAEQAANDLRAQVTELEDELT--------------------AAEDAKLRLE--- 1583
Query: 72 LGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSAT------------- 118
+ Q L + LQ + + LAK L +++ + E T
Sbjct: 1584 VTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL 1643
Query: 119 -ELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFI 177
EL+ Q+A Q A + L+ M+A K L E + + +++++ ++RE + R +
Sbjct: 1644 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS--QNRESEKR--L 1699
Query: 178 RNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELE 237
+ E ++ + A + + ++++ E+ + A+ + + R+ +LE
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1759
Query: 238 AELAMAKQSLATLTKDVPKRHSLAMPG-ETVLNGNQEWVVQADLPLTAAIRQSQQ 291
EL +QS + L D ++ L + T L+ + + +A+ RQ Q+
Sbjct: 1760 EELE-EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQE 1813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,100,221
Number of Sequences: 37866
Number of extensions: 760708
Number of successful extensions: 11008
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 383
Number of HSP's successfully gapped in prelim test: 884
Number of HSP's that attempted gapping in prelim test: 6624
Number of HSP's gapped (non-prelim): 3757
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.