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Search of human proteins with 61742825
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61742825 disrupted in schizophrenia 1 isoform Lv [Homo
sapiens]
(832 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61742825 disrupted in schizophrenia 1 isoform Lv [Homo sapiens] 1657 0.0
gi|61742823 disrupted in schizophrenia 1 isoform L [Homo sapiens] 1644 0.0
gi|61742829 disrupted in schizophrenia 1 isoform S [Homo sapiens] 1318 0.0
gi|61742827 disrupted in schizophrenia 1 isoform Es [Homo sapiens] 720 0.0
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 63 1e-09
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 60 1e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 59 2e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 3e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 58 3e-08
gi|21735548 centrosomal protein 2 [Homo sapiens] 57 9e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 56 2e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 55 2e-07
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 55 2e-07
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 55 3e-07
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 55 3e-07
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 54 6e-07
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 54 6e-07
gi|55770834 centromere protein F [Homo sapiens] 54 8e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 54 8e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 53 1e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 53 1e-06
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 53 1e-06
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 53 1e-06
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 52 2e-06
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 52 2e-06
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 52 3e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 52 3e-06
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 51 5e-06
gi|32698688 citron [Homo sapiens] 51 5e-06
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 51 5e-06
>gi|61742825 disrupted in schizophrenia 1 isoform Lv [Homo sapiens]
Length = 832
Score = 1657 bits (4290), Expect = 0.0
Identities = 832/832 (100%), Positives = 832/832 (100%)
Query: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
Query: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
Query: 661 ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER 720
ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER
Sbjct: 661 ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER 720
Query: 721 QMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHS 780
QMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHS
Sbjct: 721 QMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHS 780
Query: 781 HDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA 832
HDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA
Sbjct: 781 HDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA 832
>gi|61742823 disrupted in schizophrenia 1 isoform L [Homo sapiens]
Length = 854
Score = 1644 bits (4257), Expect = 0.0
Identities = 832/854 (97%), Positives = 832/854 (97%), Gaps = 22/854 (2%)
Query: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
Query: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
Query: 661 ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER 720
ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER
Sbjct: 661 ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER 720
Query: 721 QMDDLEGAAPPIPPRLHSEDKRKTPLK----------------------ESYILSAELGE 758
QMDDLEGAAPPIPPRLHSEDKRKTPLK ESYILSAELGE
Sbjct: 721 QMDDLEGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGE 780
Query: 759 KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREA 818
KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREA
Sbjct: 781 KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREA 840
Query: 819 AASCMTAGVHEAQA 832
AASCMTAGVHEAQA
Sbjct: 841 AASCMTAGVHEAQA 854
>gi|61742829 disrupted in schizophrenia 1 isoform S [Homo sapiens]
Length = 678
Score = 1318 bits (3411), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
Query: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
>gi|61742827 disrupted in schizophrenia 1 isoform Es [Homo sapiens]
Length = 369
Score = 720 bits (1859), Expect = 0.0
Identities = 350/355 (98%), Positives = 352/355 (99%)
Query: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1 MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
Query: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61 VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRL 355
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQME+ + L
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMELEPIAL 355
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 62.8 bits (151), Expect = 1e-09
Identities = 109/512 (21%), Positives = 203/512 (39%), Gaps = 68/512 (13%)
Query: 345 RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQ----------RLEDLEQEKISLHFQL 394
++QM+ I + QK+ +A D K + + + L++L QE + +H +
Sbjct: 835 KKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEK 894
Query: 395 PSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITR 454
+ + LS L AQV+ Q + + H + R T SL +
Sbjct: 895 RTAEAELSR-LHREVAQVR--------QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQ 945
Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTP-------- 506
+ + + L+K+IE LQ Q+ R+ I EQ+Q+++ G DLT
Sbjct: 946 MVAVTEANEALKKQIEELQ----------QEARKAITEQKQKMRRLGSDLTSAQKEMKTK 995
Query: 507 ------LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEI 560
VG LS +LQE A + A GQ+ ++ +L ERI++L L+ +
Sbjct: 996 HKAYENAVGILS-RRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAV 1054
Query: 561 T-TKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHF-WTAKDLTEEIRSLTSER 618
+ +K + ++ + ++E +LE + F K L E + L E
Sbjct: 1055 SHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALEL 1114
Query: 619 EGLEGLL-----SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKY-- 671
E +G L S + ++ + K + + ++ ++ Q ++ MK+
Sbjct: 1115 EHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLV 1174
Query: 672 ------METLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDL 725
+E K K+ S K + EA SL+L E + L + E + L
Sbjct: 1175 QALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK-EHLVQKL 1233
Query: 726 EGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDL 785
+ A + R E K + + AEL E + L++QL + E
Sbjct: 1234 QAEADDLQIR---EGKHSQEIAQ---FQAELAEARAQLQLLQKQLDEQLSKQPVGNQE-- 1285
Query: 786 IQSLRRELQMVKETLQAMILQLQPAKEAGERE 817
+++L+ E+ + +Q++ QL ++ G +E
Sbjct: 1286 MENLKWEVDQKEREIQSLKQQLDLTEQQGRKE 1317
Score = 37.4 bits (85), Expect = 0.058
Identities = 99/484 (20%), Positives = 176/484 (36%), Gaps = 73/484 (15%)
Query: 347 QMEVISLRLKLQ-KLQEDAVENDDY--DKAETLQQRLEDLEQEKISLHFQLPSRQPALSS 403
Q+ +S +L+ Q + + + D + +TL+Q DLE+ L L ++ +L+S
Sbjct: 441 QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLAS 500
Query: 404 FLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLL---EPTAQDSLHVSITRRDWLLQ 460
S +D RL+ E + L T D L Q
Sbjct: 501 ---------------------SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD-LRQ 538
Query: 461 EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVS 520
+ LQ +++ +Q L +K + + EI + QW Q L QE
Sbjct: 539 QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWY---------QQQLALAQEAR 589
Query: 521 KALQDTLA--SAGQIPFHAEPPETIRSLQERIKSLNLSL-KEITTKVCMSEKFCSTLRKK 577
LQ +A GQ+ T L E +K N+SL +++T S K + +
Sbjct: 590 VRLQGEMAHIQVGQM--------TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQ 641
Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSR-NV 636
+ IE + EA I +DL + ERE L+ + L +
Sbjct: 642 LQGIEADM-LDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQ 700
Query: 637 KKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLE 696
KL ++ D + EH + + ++ + ++ E + L + L ++ E E
Sbjct: 701 VKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE 760
Query: 697 ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAEL 756
A +R + + LE A D+ L+E + E
Sbjct: 761 AA-----------SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEG---TEET 806
Query: 757 GEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGER 816
E E + ++L Q+ H + +L++++Q +KE LQ + EA R
Sbjct: 807 SETLEKLREELAIKSGQV-----EHLQQETAALKKQMQKIKE----QFLQQKVMVEAYRR 857
Query: 817 EAAA 820
+A +
Sbjct: 858 DATS 861
Score = 36.6 bits (83), Expect = 0.099
Identities = 86/436 (19%), Positives = 177/436 (40%), Gaps = 58/436 (13%)
Query: 380 LEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRL 439
LE L+ E +SL QL Q G +AAQ+Q Q+A+ ++ +
Sbjct: 610 LEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAA----FMQIQEAKTM 665
Query: 440 LEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQW 499
+E Q R + E+++LQ+ ++ + LE + +Q++ + +++QQL+
Sbjct: 666 VEEDLQ-------RRLEEFEGERERLQRMADSAAS----LEQQLEQVKLTLLQRDQQLEA 714
Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKE 559
+ L+ QL+L Q +ALQ +++ +LQ L L E
Sbjct: 715 LQQEHLDLMKQLTLTQ-----EALQSR-------------EQSLDALQTHYDELQARLGE 756
Query: 560 ITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWT--AKDLTEEIRSLTSE 617
+ + E L+ + +E L A K G ++ +E + L E
Sbjct: 757 LQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE 816
Query: 618 REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKN 677
G + L ++ K++ +KE + L+++V + + + K+ + ++ +
Sbjct: 817 LAIKSGQVEHLQQETAALKKQMQKIKEQF--LQQKVMVEAYRRDATSKDQLISELKATRK 874
Query: 678 KLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQ-MDDLEGAAPPIPPRL 736
+L S L ++ + E ++ + + +R V RQ M DLEG L
Sbjct: 875 RLDSELKELRQELMQVHGEK-----RTAEAELSRLHREVAQVRQHMADLEG-------HL 922
Query: 737 HSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMV 796
S K + + E+++ S + K+ + + + A+ E+L Q R+ +
Sbjct: 923 QSAQKERDEM-ETHLQSLQ-------FDKEQMVAVTEANEALKKQIEELQQEARKAITEQ 974
Query: 797 KETLQAMILQLQPAKE 812
K+ ++ + L A++
Sbjct: 975 KQKMRRLGSDLTSAQK 990
Score = 34.3 bits (77), Expect = 0.49
Identities = 99/457 (21%), Positives = 177/457 (38%), Gaps = 73/457 (15%)
Query: 373 AETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTP 432
AET ++ L+ L+ EK+ L QL + L+ + AL+ A QA T
Sbjct: 401 AETQEEMLQVLK-EKMRLEGQLEA-----------LSLEASQALKEKAELQAQLAALSTK 448
Query: 433 LRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEE 492
L+ + + H S R+D L E++ L+ + LE L+ +E
Sbjct: 449 LQAQV--------ECSHSSQQRQD-------SLSSEVDTLKQSCWDLERAMTDLQNMLEA 493
Query: 493 QEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS--AGQIPFHAEPPETIRSLQERI 550
+ L DL Q++ Q Q + ++D S + H + + + +LQ ++
Sbjct: 494 KNASLASSNNDL-----QVAEEQYQRLMAKVEDMQRSMLSKDNTVH-DLRQQMTALQSQL 547
Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE 610
+ + L +T+K+ S+ S+L+ + QL EA++ +T+
Sbjct: 548 QQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQA 607
Query: 611 --IRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY------ET 662
+ L E L +L R++K+ G + + ++ QE A+ +T
Sbjct: 608 GLLEHLKLENVSLS---QQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKT 664
Query: 663 SVKENTMKYMETLK------NKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSV 716
V+E+ + +E + ++ L E LE +L + LQ + +L
Sbjct: 665 MVEEDLQRRLEEFEGERERLQRMADSAASL-----EQQLEQVKLTL--LQRDQQLEALQQ 717
Query: 717 EDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGE------KCED----IGKK 766
E M L + R S D +T E L A LGE ED + +
Sbjct: 718 EHLDLMKQLTLTQEALQSREQSLDALQTHYDE---LQARLGELQGEAASREDTICLLQNE 774
Query: 767 LLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAM 803
+ LE L A S E+L + RR + +ET + +
Sbjct: 775 KIILEAALQAA-KSGKEELDRGARRLEEGTEETSETL 810
Score = 33.1 bits (74), Expect = 1.1
Identities = 51/218 (23%), Positives = 90/218 (41%), Gaps = 37/218 (16%)
Query: 330 LRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDK--AETLQQRLEDLEQEK 387
LR+ +L L + R+ +++ L L++Q + + E D K + LQ LE +++
Sbjct: 1131 LREHNSILETALAK--READLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
Query: 388 ISLHFQLPSRQ----------PALSSFLGHLAAQVQAALRRGATQQASGDDTH------- 430
SL Q+ + + A S L + ++QA QA DD
Sbjct: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
Query: 431 ----------TPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEKQQLQKEIEALQARMF 477
R + +LL+ + L V + L E Q ++EI++L+ +
Sbjct: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQ-- 1306
Query: 478 VLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQ 515
L+ +QQ R+E+E +Q LQ +L LS+ Q
Sbjct: 1307 -LDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ 1343
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 59.7 bits (143), Expect = 1e-08
Identities = 151/668 (22%), Positives = 264/668 (39%), Gaps = 133/668 (19%)
Query: 145 QEFAAMDSSE------TLDASWEAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPT 198
QE AA+++ + TL +A SD V+ +GS +A+ +SN G + P+
Sbjct: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTAD-ASNGSLRGLSGQRTPS 494
Query: 199 PPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPS-----------------REAESHCQS 241
PP S G + RG + C S ++ ++
Sbjct: 495 PPRRSSP----------GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544
Query: 242 PQE-MGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
Q+ +G L + R L L + + QA ++ R + + S ++
Sbjct: 545 SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM-QAHEDAQREVQRLRSANELLSR 603
Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
S+L AHS ++ E + ++ Q E+ R +L++
Sbjct: 604 EKSNL-----------------AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646
Query: 361 QEDAVENDD--YDKAETLQQRLEDLEQEKISLHFQLPSRQPALS------SFLGHLAAQV 412
QEDAV++ + E ++LE LE ++ L +L + ALS L A+V
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Query: 413 QAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEK-------QQL 465
AL + + + + T LR E E + QDSL + L Q+K QL
Sbjct: 707 AEALTKAEAGRVELELSMTKLRAE----EASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762
Query: 466 QKEIEALQARMFVLE-----AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLS-------L 513
++E ALQ R E A+++Q R E EQ++ QG + + V + + L
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822
Query: 514 GQLQEVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKE----------IT 561
L+ LQ+ LA + E + R Q ++++L + +E +
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882
Query: 562 TKVCMSEKFCSTLRKKVNDIETQLPAL-------------LEAKMHAI--SGNHFWTAKD 606
++ +E+ TL ++ + + AL LEA+ + G AK+
Sbjct: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 607 -LTEEIRSL------TSEREGLE-GLLSKLLVLSSRNV-----KKLGSVKEDYNRLRREV 653
LT E+ L T E+ L+ L+++ LV + R ++ + +ED RL+RE
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQRE- 1001
Query: 654 EHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGS 713
+E A+ E L+++L + LL ++ EA+ E I +LQ + G
Sbjct: 1002 --KEAAWRELEAERAQ-----LQSQLQREQEELLARL-EAEKEELSEEIAALQQERDEGL 1053
Query: 714 LSVEDERQ 721
L E E+Q
Sbjct: 1054 LLAESEKQ 1061
Score = 47.4 bits (111), Expect = 6e-05
Identities = 112/474 (23%), Positives = 196/474 (41%), Gaps = 84/474 (17%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALS 402
R R + + RL+L+K +A+E ++ +Q++L LE + L + + A
Sbjct: 890 REGRTLSEEATRLRLEK---EALEGSLFE----VQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 403 SFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLL--EPTAQDSLHVSITRRDWLLQ 460
+ G LA Q + ATQ+ + D M +L+ E AQ SL + +
Sbjct: 943 TLTGELAGLRQQII---ATQEKASLDKEL---MAQKLVQAEREAQASLREQRAAHE---E 993
Query: 461 EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVS 520
+ Q+LQ+E EA LEA+ QL+ +++ ++++L L +L+
Sbjct: 994 DLQRLQREKEAAWRE---LEAERAQLQSQLQREQEEL---------------LARLEAEK 1035
Query: 521 KALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVND 580
+ L + +A+ Q E E + L E K LSLKE + K +SEK T R +
Sbjct: 1036 EELSEEIAALQQ-----ERDEGLL-LAESEKQQALSLKE-SEKTALSEKLMGT-RHSLAT 1087
Query: 581 IETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLG 640
I ++ + T LT E+R L ++RE ++ + + LG
Sbjct: 1088 ISLEMERQKRDAQSRQEQDRS-TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146
Query: 641 SVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRL 700
++ R E+ Q E + + L+ +L LEA R
Sbjct: 1147 KQRDSCLREAEELRTQLRLLEDA--------RDGLRREL---------------LEAQRK 1183
Query: 701 LIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLK-ESYILSAELGEK 759
L +S + +E + + E R + EGA R +E+ R K ES +S +L
Sbjct: 1184 LRESQEGREVQRQEAGELRRSLG--EGAKEREALRRSNEELRSAVKKAESERISLKLAN- 1240
Query: 760 CEDIGKKLLYLED----------QLHTAIHSHDEDLIQSLRRELQMVKETLQAM 803
ED +KL LE+ +L T + + +++ RRELQ ++ ++ +
Sbjct: 1241 -EDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA-RRELQELRRQMKML 1292
Score = 42.0 bits (97), Expect = 0.002
Identities = 85/388 (21%), Positives = 158/388 (40%), Gaps = 38/388 (9%)
Query: 360 LQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRG 419
LQE++V + ++ TL Q + LE+ + +L + Q +S + +++ RR
Sbjct: 1583 LQEESVRRSERERRATLDQ-VATLERSLQATESELRASQEKISKMKAN-ETKLEGDKRRL 1640
Query: 420 ATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVL 479
+ + L ++ R LE Q S + ++ R+ + Q LQ +++LQ ++
Sbjct: 1641 KEVLDASESRTVKLELQRRSLEGELQRS-RLGLSDRE---AQAQALQDRVDSLQRQVADS 1696
Query: 480 EAKDQQLR----------REIEEQEQQLQWQGCDLTPLVGQ--LSLGQLQEVSKALQDTL 527
E K L+ ++EE E L+ + LT + Q SL ++ + LQ L
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
Query: 528 ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIET---- 583
+ + LQER+ + +L E + + TLR +V D+E
Sbjct: 1757 TAC---------EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
Query: 584 ---QLPALLEAKMHAISGN--HFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
QL L E G T + L +E R L L+ L++L +
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEAC 698
+++D LRR ++ E S E+T++ + K +L ++ EA +
Sbjct: 1868 ALRLEKDRVALRRTLDKVEREKLRS-HEDTVR-LSAEKGRLDRTLTGAELELAEAQRQIQ 1925
Query: 699 RLLIQSLQLQEARGSLSVEDERQMDDLE 726
+L Q + L+++ +E + Q LE
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLE 1953
Score = 39.3 bits (90), Expect = 0.015
Identities = 86/387 (22%), Positives = 158/387 (40%), Gaps = 28/387 (7%)
Query: 268 LLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWD 327
L+ TR S LA + R +RD S + D + ++L L + AH+ +
Sbjct: 1078 LMGTRHS--LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAA-AHAQE 1134
Query: 328 TLLRKWEPVLRDC-LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQE 386
+R+ + RD R+ E LR +L +L EDA + + E ++ E E
Sbjct: 1135 --VRRLQEQARDLGKQRDSCLREAEELRTQL-RLLEDARDGLRRELLEAQRKLRESQEGR 1191
Query: 387 KISLHFQLPSRQPA--LSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTA 444
++ RQ A L LG A+ + ALRR + S R+ +L
Sbjct: 1192 EVQ-------RQEAGELRRSLGE-GAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243
Query: 445 QDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDL 504
+ L + R + +E +L+ ++ ++ + Q+LRR+++ + + G +L
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
Query: 505 TPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIR-SLQERIKSLNLSLKEITTK 563
L G+L+LG+ E ++ ++TL ++ E +R LQ + L E T+
Sbjct: 1304 AELQGRLALGERAE-KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Query: 564 VCMSEKFCSTLRKKVNDIETQLPAL--LEAKMHAISGNHFWTAKDLTEEIRSLTSEREGL 621
+ +L + + QL LE K+ A A +L + + +GL
Sbjct: 1363 ---ERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE----AAELGLRLSAAEGRAQGL 1415
Query: 622 EGLLSKLLVLSSRNVKKLGSVKEDYNR 648
E L+++ V +LG ++ R
Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRR 1442
Score = 35.8 bits (81), Expect = 0.17
Identities = 88/413 (21%), Positives = 168/413 (40%), Gaps = 78/413 (18%)
Query: 375 TLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR 434
TL+ ++ LE + L +R A + + L A ++ + R +Q S
Sbjct: 14 TLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES--------- 64
Query: 435 MEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREI---- 490
P LL T SL L +E Q LQ+E+ ++ + A+ +L +
Sbjct: 65 --PVLLPATEMASLLS-------LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115
Query: 491 EEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERI 550
E EQ L+ + +L + + Q E+ + LQ+ AS + +++ QE
Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRR---------KLQAYQEGQ 166
Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKV------------------NDIETQLPALLEAK 592
+ ++ + K+ +K CS L +++ D+E+ L L E +
Sbjct: 167 QRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ 226
Query: 593 MHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRRE 652
+ S ++ ++ E+ G ++ L S +++K V D+ R R+E
Sbjct: 227 QRSAS----------LAQVNAMLREQLDQAGSANQAL---SEDIRK---VTNDWTRCRKE 270
Query: 653 VEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLG---KVWEADLEACRLLIQSLQLQE 709
+EH+E A+ +E+ Y ++L ++G V E + R L+Q L +
Sbjct: 271 LEHREAAWRRE-EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ-LGGEL 328
Query: 710 ARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCED 762
AR S +V++ G RL +E + + L++ +L A+L E+ D
Sbjct: 329 ARTSRAVQE-------AGLGLSTGLRL-AESRAEAALEKQALLQAQLEEQLRD 373
Score = 35.0 bits (79), Expect = 0.29
Identities = 39/158 (24%), Positives = 72/158 (45%), Gaps = 8/158 (5%)
Query: 347 QMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLG 406
+++ + +LQ+L+E + + + A ++ L+ E+ L +L S Q AL+
Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAAL--NTVQKLQDERRLLQERLGSLQRALAQLEA 1859
Query: 407 HLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQ----EK 462
++ALR + A R + R E T + L R D L E
Sbjct: 1860 EKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR--LSAEKGRLDRTLTGAELEL 1917
Query: 463 QQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQ 500
+ Q++I+ L+A++ VLE + E++ Q+QQL+ Q
Sbjct: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQ 1955
Score = 33.5 bits (75), Expect = 0.83
Identities = 89/423 (21%), Positives = 171/423 (40%), Gaps = 60/423 (14%)
Query: 454 RRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSL 513
+ D +Q + Q+E++ L++ +L + L ++ +QQ + + L Q +
Sbjct: 576 KTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKL--QAAQ 633
Query: 514 GQLQEVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKE-ITTKVCMSEKF 570
+L+ L++ A Q E + R L++ ++ KE + + +S
Sbjct: 634 EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR-- 691
Query: 571 CSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLV 630
+TL++ + ++ + + EA A +G +L + L +E L+ LSKL
Sbjct: 692 -ATLQRDM--LQAEKAEVAEALTKAEAGR-----VELELSMTKLRAEEASLQDSLSKLSA 743
Query: 631 LSSRNVKKLGSVKEDYNRLRREVEHQETA---------YETSVKENTMKYMETLKNKLCS 681
L+ + L K D NRL ++E +++A E +V + +E L+ +
Sbjct: 744 LN----ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEV 799
Query: 682 CKCPLLG--KVWEADLEACRLLIQSL-----QLQEARGSLSVEDERQMDDLEGAAPPIPP 734
+ L G +V E EA + +L QLQE LS + + +LE A
Sbjct: 800 ARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859
Query: 735 RLHSEDK----RKTPLKESYILSAEL------GEKCEDIGKKLLYLEDQLHTAIHSHDED 784
++ + ++ ++ KE L+ +L G + +L ++ L ++
Sbjct: 860 QVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
Query: 785 LIQ-SLRRE--------LQMVKETLQAMILQLQ------PAKEAGEREAAASCMTAGVHE 829
L Q RRE L + KETL + L+ K + ++E A + E
Sbjct: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 830 AQA 832
AQA
Sbjct: 980 AQA 982
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/392 (23%), Positives = 170/392 (43%), Gaps = 69/392 (17%)
Query: 459 LQEKQQLQKEIEALQARMFVLEA---KDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQ 515
L + + +KE+ +++ L+ K + R+E+EE+ L + DL Q
Sbjct: 839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL----------Q 888
Query: 516 LQEVSKALQDTLASAGQ-----IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKF 570
LQ +A QD LA A + I + ++ + ER++ E+T K E
Sbjct: 889 LQV--QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 571 CSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLV 630
CS L++ ++D+E L A +E + HA ++++LT E GL+ +++KL
Sbjct: 947 CSELKRDIDDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDEIIAKL-- 992
Query: 631 LSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTM--KYMETLKNKLCSCKCPLLG 688
K+ +++E + + +++ +E T K + ++ L+ L K
Sbjct: 993 -----TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK----- 1042
Query: 689 KVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPL-- 746
KV DLE + ++ G L + E M DLE + RL +D L
Sbjct: 1043 KV-RMDLERAK--------RKLEGDLKLTQESIM-DLENDKQQLDERLKKKDFELNALNA 1092
Query: 747 --KESYILSAELGEKCEDIGKKLLYLEDQLHT--AIHSHDEDLIQSLRRELQMVKETLQ- 801
++ L ++L +K +++ ++ LE++L + E L L REL+ + E L+
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Query: 802 ---AMILQLQPAKEAGEREAAASCMTAGVHEA 830
A +Q++ K +REA M + EA
Sbjct: 1153 AGGATSVQIEMNK---KREAEFQKMRRDLEEA 1181
Score = 47.4 bits (111), Expect = 6e-05
Identities = 67/390 (17%), Positives = 163/390 (41%), Gaps = 38/390 (9%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q+ ++ +EA+ A+ LE +L+ EIE+ ++ + L
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA---------AAAALD 1443
Query: 518 EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
+ + LA Q + E + S Q+ +SL+ L ++ S + T +++
Sbjct: 1444 KKQRNFDKILAEWKQ--KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
+++ ++ L E G+ T +L + + L +E+ L+ L +
Sbjct: 1502 NKNLQEEISDLTEQ-----LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 638 KLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSCKC 684
K+ + ++N+++ E+E + + + K N ++ +++L +N+ K
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKK 1616
Query: 685 PLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ G + E +++ A R+ ++ + ++ SL + + Q+DD A + + ++
Sbjct: 1617 KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1676
Query: 742 RKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRR---ELQM 795
R L+ E E E+ + ++ L + +HS + LI ++ +L
Sbjct: 1677 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Query: 796 VKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ + + + A+E ++ + M A
Sbjct: 1737 LQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766
Score = 42.7 bits (99), Expect = 0.001
Identities = 96/487 (19%), Positives = 197/487 (40%), Gaps = 76/487 (15%)
Query: 345 RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQE---KISLHFQLPSRQPAL 401
++ E+ +L +++ E A+ + K + LQ R+E+LE+E + + ++ + L
Sbjct: 1082 KKDFELNALNARIE--DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 402 SSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQE 461
S L ++ +++ A + Q + R LE + R
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 462 KQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL--SLGQLQEV 519
+L ++I+ L Q++++++E+++ + + + D+T + Q+ + L+++
Sbjct: 1200 VAELGEQIDNL-----------QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Query: 520 SKALQDTLASAGQIPFHAEPPETIRS----------LQERIKSLNLSLKEITTKVCMSEK 569
+ L+D + ++ ET RS LQ L+ L E + +
Sbjct: 1249 CRTLEDQMNE-----HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTR 1303
Query: 570 FCSTLRKKVNDIETQLPALLEAK---MHAI-SGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
T +++ D++ QL ++AK HA+ S H L E+ T + L+ +L
Sbjct: 1304 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH--DCDLLREQYEEETEAKAELQRVL 1361
Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCP 685
SK EV T YET + T + +E K KL
Sbjct: 1362 SK---------------------ANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQ---- 1395
Query: 686 LLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLE---GAAPPIPPRLHSEDKR 742
++ EA+ + + L++ + L E E M D+E AA + + + DK
Sbjct: 1396 ---RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 743 KTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDL--IQSLRRELQMVKETL 800
K+ Y E + E K+ L +L ++++E L +++ +RE + ++E +
Sbjct: 1453 LAEWKQKY---EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 801 QAMILQL 807
+ QL
Sbjct: 1510 SDLTEQL 1516
Score = 39.7 bits (91), Expect = 0.012
Identities = 103/532 (19%), Positives = 200/532 (37%), Gaps = 87/532 (16%)
Query: 326 WDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQ 385
W L K +P+L+ R+ E+ S++ + +L+E A+E + + E L++++ L Q
Sbjct: 829 WMKLYFKIKPLLKSA----EREKEMASMKEEFTRLKE-ALEKSEARRKE-LEEKMVSLLQ 882
Query: 386 EKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ 445
EK L Q+ + Q
Sbjct: 883 EKNDLQLQVQAEQ----------------------------------------------- 895
Query: 446 DSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQL---RREIEEQEQQLQWQGC 502
D+L + R D L++ K QL+ +++ + R+ E + +L +R++E++ +L+
Sbjct: 896 DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 503 DLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITT 562
DL + ++ + +K T AG A+ + ++LQE + L+
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 563 KVCMSEKFCSTLRKKVNDIETQLPAL------LEAKMHAISGNHFWT----------AKD 606
KV K L ++V+D+E L LE + G+ T +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 607 LTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYE--TSV 664
L E ++ E L + L S+ KKL ++ L E+E + TA +
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 665 KENTMKYMETLKNKL-----CSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDE 719
+ + + +E + +L + + K EA+ + R ++ LQ + ++ +
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR-K 1194
Query: 720 RQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIH 779
+ D + I + K + E + ++ E I K LE T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 780 SHDEDLIQSLRRELQMVKETLQAMILQLQP-----AKEAGEREAAASCMTAG 826
+E +S E Q L + +LQ +++ E+EA S +T G
Sbjct: 1255 QMNEH--RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.2 bits (139), Expect = 3e-08
Identities = 115/509 (22%), Positives = 200/509 (39%), Gaps = 76/509 (14%)
Query: 337 LRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPS 396
L LL RQ+ RLK Q+ D + LQ +L LE++
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL--------K 470
Query: 397 RQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD--SLHVSITR 454
+ S+ L H Q+ ++ QQA T LR LE + I
Sbjct: 471 EKVTNSTELQH---QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 455 RDWLLQEKQQ----LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQ 510
+ LLQ+ ++ L+KE E L A++ E + L +++E+ LQ Q LT
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL-NQLQEKNHTLQEQVTQLTE---- 582
Query: 511 LSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKF 570
L E K Q+ L Q E +R+ Q+R+ SL S+ E+ +++ S
Sbjct: 583 -KLKNQSESHKQAQENLHDQVQ-----EQKAHLRAAQDRVLSLETSVNELNSQLNES--- 633
Query: 571 CSTLRKKVNDIETQLPALLEAKMHAISG---------NHFWTA----KDLTEEIRSLTSE 617
++KV+ ++ Q+ A E + A + NH TA +D +E+ +T++
Sbjct: 634 ----KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 618 REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKN 677
+ + L S+ L KE Y L ++ E E +K+ +E +
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE----LEGQIKKLEADSLEVKAS 745
Query: 678 KLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQ--------MDDLEGAA 729
K + + DL+ R L L+L+ S +E E++ + A
Sbjct: 746 KEQALQ----------DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 730 PPIPPRLHSEDKRKTPLKESY-ILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQS 788
I +L +++ K LK+ + LS E + E++ ++ +L ++
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK-----EA 850
Query: 789 LRRELQMVKETLQAMILQLQPAKEAGERE 817
L EL VK+ L + L+ +K E+E
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Score = 50.8 bits (120), Expect = 5e-06
Identities = 84/456 (18%), Positives = 189/456 (41%), Gaps = 52/456 (11%)
Query: 361 QEDAVENDDYD-KAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRG 419
QE +++++ + + +T L+ ++ EK +L +L + + LS L +
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 420 ATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ---QLQKEIEALQARM 476
+A+ D + L+ +++L + L +EK+ QL+ E+ ++Q ++
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 477 FVL-------EAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ--EVSKALQDTL 527
E ++QQL+ I E +Q + + + L G+L + LQ E+ LQ L
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 528 ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPA 587
A Q A E I LQ + + K++ + E R+ + +E +L
Sbjct: 1001 TQAAQ--ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 588 LLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYN 647
E DL + ++ + ++ L + L + KK ++E
Sbjct: 1059 AQE---------------DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 648 RLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQL 707
L Q+ E S+KE + ++ ++ KC ++ + + E ++S +L
Sbjct: 1104 AL------QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE-----LKSHKL 1152
Query: 708 QEARGSLSVEDERQM-----DDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCED 762
+ + +++D +Q+ +L+G A + + E + + LK+ ++ ++ E+
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD------QVKKEEEE 1206
Query: 763 IGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKE 798
+ K+ + E +LH+ I + + + E ++ +
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
Score = 44.7 bits (104), Expect = 4e-04
Identities = 99/503 (19%), Positives = 199/503 (39%), Gaps = 98/503 (19%)
Query: 355 LKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQV-- 412
L+ Q+ + D + D + ++L+Q+LE+ + E +F + + LA ++
Sbjct: 119 LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE----NFNIKQMKDLFEQKAAQLATEIAD 174
Query: 413 -------QAALRRGATQQASGDDTHTPLRMEPRL-LEPTAQDSLHVSITRRDWLLQEKQQ 464
+ +LR A Q+ + R+ L E T L + +R +++
Sbjct: 175 IKSKYDEERSLREAAEQKVT--------RLTEELNKEATVIQDLKTELLQRPG-IEDVAV 225
Query: 465 LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQ 524
L+KE+ +Q M + + ++ +++++ ++LQ Q + QL E++K Q
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR----SELAKGPQ 281
Query: 525 DTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQ 584
+ A + ++ L+ + L + +T + E+ + L +K N+ E+
Sbjct: 282 EV----------AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE-ESV 330
Query: 585 LPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKE 644
++A +H KDL + + L S E L ++ V S + +KE
Sbjct: 331 SKKNIQATLH---------QKDL--DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379
Query: 645 DYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQS 704
+ + + + +H + ++ ++ K L+ + E + +LL
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS------------EINQLHSKLLETE 427
Query: 705 LQLQEARGSLS----------VEDERQMDDLEGAAPPIPPRL-----------HSEDKRK 743
QL EA G L ++ E+Q+ DL+ + +L H DK K
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 744 TPLKESYIL----SAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKET 799
+E L +A+L E D+ + L + D+ + IQ+L LQ KE
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK---------DQKIQNLEALLQKSKEN 538
Query: 800 LQAMILQ---LQPAKEAGEREAA 819
+ + + L +AGE E A
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETA 561
Score = 40.8 bits (94), Expect = 0.005
Identities = 99/466 (21%), Positives = 187/466 (40%), Gaps = 61/466 (13%)
Query: 356 KLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISL---HFQLPSRQPALSSFLGHLAAQV 412
+LQKL+ N+ K +TL + L EQ+ L H + + + + L
Sbjct: 289 ELQKLKSSV--NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 413 QAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEAL 472
Q R + + S H L + + ++ V T+ L E +QLQ++ E
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE-TKYQHLKAEFKQLQQQREEK 405
Query: 473 QARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQ 532
+ L+++ QL ++ E E+QL G+ + G+L+E + + L
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQL-----------GE-AHGRLKEQRQLSSEKL----- 448
Query: 533 IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAK 592
+ + + LQ ++ L LKE KV S + L K + Q +A
Sbjct: 449 ----MDKEQQVADLQLKLSRLEEQLKE---KVTNSTELQHQLDKTKQQHQEQ-----QAL 496
Query: 593 MHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRRE 652
+ + DL + +R + + + ++ L LL S N+ L +ED L +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKERED---LYAK 552
Query: 653 VEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARG 712
++ E ET+V + TL+ ++ L + E+ +A L Q+QE +
Sbjct: 553 IQAGEG--ETAVLNQLQEKNHTLQEQVTQLTEKLKNQS-ESHKQAQENLHD--QVQEQKA 607
Query: 713 SLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPL------KESYILSAELGEKCEDIGKK 766
L +R + LE + + +L+ ++ + L K +LSAE + +
Sbjct: 608 HLRAAQDRVL-SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD-- 664
Query: 767 LLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKE 812
L++ L TA ++ +Q ++EL + L + +LQ +E
Sbjct: 665 ---LQNHLDTA-----QNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Score = 37.7 bits (86), Expect = 0.044
Identities = 89/417 (21%), Positives = 168/417 (40%), Gaps = 66/417 (15%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQ-EQQLQWQGCDLTPL-VGQLSLGQ 515
L Q +Q +K+IEALQ + + + +L ++++Q Q Q + + V Q + +
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Query: 516 LQEVSKALQ--------DTLASAGQIPFHAE----PPETIRSLQERIKSLNLSLKEITTK 563
QE K LQ + LA+ + E E + S + +I + N ++E+ T
Sbjct: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
Query: 564 VCMSEKFCSTLRKKVNDIETQLPALLE-AKMHAISGNHFWTAKDLTEEIRSLTSERE-GL 621
E+ + KK ++ + AL + K ++ K EI + +E +
Sbjct: 1084 KATLEQDSA---KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 622 EGLLSKLLVLSSRNVKKLGSVKE--------------DYNRLRREVEHQETAYETSVKEN 667
L +L ++K++ ++K+ + L+ VE QE + +K+
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE-QEKRNQQILKDQ 1199
Query: 668 TMKYMETLKNKLCSCKCPLLGKVWEADL-------EACRLLIQSLQLQEARGSLS----- 715
K E LK + + L ++ E ++ +L +Q L E G++
Sbjct: 1200 VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
Query: 716 -----VEDERQMDDLEGAAPPIPPRL-HSEDKRKTPLKESYILSAELGEKCEDIGKKLLY 769
E E+Q DDL G + + +++D+R+ L+ E+ E + K+L
Sbjct: 1260 SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI----EKLQTKVLE 1315
Query: 770 LEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAG 826
L+ +L + +Q L RE ++LQ Q K A + E +CM G
Sbjct: 1316 LQRKLDNTTAA-----VQELGRE----NQSLQIKHTQALNRKWAEDNE-VQNCMACG 1362
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 58.2 bits (139), Expect = 3e-08
Identities = 81/348 (23%), Positives = 151/348 (43%), Gaps = 49/348 (14%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
+E +++E E + + EAK R+E+EE+ L + DL QL Q+Q
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAK----RKELEEKMVTLMQEKNDL-----QL---QVQAE 898
Query: 520 SKALQDTLASAGQ-IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
+ AL D Q I + I+ + ER + E+T K E CS L+K +
Sbjct: 899 ADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
+D+E L A +E + HA ++++LT E GL+ ++KL K+
Sbjct: 959 DDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDETIAKL-------TKE 999
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEAC 698
+++E HQ+T + ++E+ + + K KL L G + E + + C
Sbjct: 1000 KKALQE---------AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSL-EQEKKLC 1049
Query: 699 RLLIQSLQLQEARGSLSVEDERQMD---DLEGAAPPIPPRLHSEDKRKTPLKESYILSAE 755
L ++ + E G L + E MD D + + + + +++ L+ +
Sbjct: 1050 MDLERAKRKLE--GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQ 1107
Query: 756 LGEKCEDIGKKLLYLEDQLHT--AIHSHDEDLIQSLRRELQMVKETLQ 801
L +K +++ ++ LE+++ A + E L REL+ + E L+
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155
Score = 47.0 bits (110), Expect = 7e-05
Identities = 77/402 (19%), Positives = 174/402 (43%), Gaps = 45/402 (11%)
Query: 371 DKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALR--RGATQQASGDD 428
DK TL + LEQ+ L L ++ L L +++ L+ + +T D
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSL-EQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 429 THTPLRMEPRLLEPTA-------QDSLHVSITRRDWLLQEK-QQLQKEIEALQARMFVLE 480
+++ + E + + +L + + ++ LQ + ++L++EIEA +A E
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLV--GQLSLGQLQEVSKALQDTLA--SAGQIPFH 536
+ L RE+EE ++L+ G + + + + Q++ + L+++ A
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALR 1197
Query: 537 AEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAI 596
+ +++ L E+I SL +++ EK S L+ ++ND+ + + + +AK
Sbjct: 1198 KKHADSVAELGEQIDSLQRVKQKL-------EKEKSELKMEINDLASNMETVSKAK---- 1246
Query: 597 SGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLS----------SRNVKKLGSVKEDY 646
N + L +++ + ++ E + L+++L SR + + ++
Sbjct: 1247 -ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 647 NRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCK--CPLLGKVWEADLEACRLLIQS 704
+R ++ Q + ++E T K TL + L S + C LL + +E + EA L +
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEET-KAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 705 L-----QLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ ++ + R + ++ ++LE A + RL ++
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
Score = 37.0 bits (84), Expect = 0.075
Identities = 66/391 (16%), Positives = 163/391 (41%), Gaps = 40/391 (10%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++ +EA+ ++ LE Q+L+ E+E+ ++ + L
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA---------ACIALD 1447
Query: 518 EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
+ + LA Q + E + + Q+ +SL+ L ++ S TL+++
Sbjct: 1448 KKQRNFDKVLAEWKQ--KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505
Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
+++ ++ L E A G H +L + + L E+ L+ L +
Sbjct: 1506 NKNLQQEISDLTE--QIAEGGKHI---HELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560
Query: 638 KLGSVKEDYNRLRREVEHQETAYE---TSVKENTMKYMETL----------KNKLCSCKC 684
K+ ++ + N+++ E++ + + +K N ++ +E++ +N K
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK 1620
Query: 685 PLLGKVWEADLE---ACRLLIQSLQ-LQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED 740
+ G + E +++ A R ++L+ L+ +G L + + +DD + +L +
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK-DTQLHLDDAIRGQDDLKEQLAMVE 1679
Query: 741 KRKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRRELQ 794
+R ++ E S E E+ + ++ L + +H+ + LI + L ++
Sbjct: 1680 RRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 795 MVKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ ++ + + A+E ++ + M A
Sbjct: 1740 QIQGEMEDIVQEARNAEEKAKKAITDAAMMA 1770
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 56.6 bits (135), Expect = 9e-08
Identities = 113/493 (22%), Positives = 199/493 (40%), Gaps = 87/493 (17%)
Query: 352 SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF--LGHLA 409
S RL Q++QE E +Y++ + ++LE+EK SL L ++ L +
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQ------KELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 410 AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEI 469
Q +ALR+ Q+A G+ +ME LL ++ D+L QE Q L+ E+
Sbjct: 1079 QQELSALRQDM-QEAQGEQKELSAQME--LLRQEVKEK------EADFLAQEAQLLE-EL 1128
Query: 470 EA-------LQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKA 522
EA L+A ++ EAK QL+ + E QL+ + P + QL + A
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Query: 523 LQDTLAS-------------AGQIPFHAEPPET-IRSLQER--------IKSLNLSLKEI 560
LQ L S + + EP + RSL +R +++ +L ++
Sbjct: 1189 LQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL 1248
Query: 561 TTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREG 620
+ +++ LR +V +E +L A +DL ++ E+
Sbjct: 1249 HQDLWKTQQTRDVLRDQVQKLEERL-----TDTEAEKSQVHTELQDLQRQLSQNQEEKSK 1303
Query: 621 LEGLLSKLLVLSSRNVKKLGSVKEDYNRLRR-EVEHQETAYETSVKENTMKYMETLKNKL 679
EG K L S ++ ++ +RLRR E++ E E + ++ K L
Sbjct: 1304 WEG---KQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL-------LQAAKENL 1353
Query: 680 CSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSE 739
+ L V EA +A I L+ AR +L +++E + SE
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE---------------EVESE 1398
Query: 740 DKRKTPLKESYILSAELGEKCED----IGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQM 795
+R L+E L G+ ++ + + L E+++ T IQ L ++ +M
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL-----RGQIQELEKQREM 1453
Query: 796 VKETLQAMILQLQ 808
K L+ + L L+
Sbjct: 1454 QKAALELLSLDLK 1466
Score = 55.5 bits (132), Expect = 2e-07
Identities = 117/532 (21%), Positives = 218/532 (40%), Gaps = 96/532 (18%)
Query: 348 MEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPS---RQPALSSF 404
++ + L +L +L+E+ +++ R+E EQ + +L L R+ AL
Sbjct: 610 LDKVGLNQQLLQLEEEN---------QSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
Query: 405 LGHLAAQVQAALRRGATQQAS-GDDTHTPLRMEPRLLE--------PTAQDSLHVSITRR 455
HL AQ+Q A GA QA D ++ +L E T + LH R+
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 456 DWLL----QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
+ +L QEK+ L +E AL+ R+ +E Q L ++ QG + +
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL---------QGLSSAKELLES 771
Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLK-EITTKVCMSEKF 570
SL + Q+ + ++ T GQ+ +T+ +E I+ LK E+ T+ +E+
Sbjct: 772 SLFEAQQQNSVIEVT---KGQLEVQI---QTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 571 CSTLRKKVNDIETQLPALLEAK--MHAISGNHF---------WTAKDLTEEIRSLTSERE 619
+++ E + LE + H N W ++L + + SL E+
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM 885
Query: 620 GLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKL 679
LE +L + + ++ + E + T E+++ +ET K ++
Sbjct: 886 ELE--------------MRLKEQQTEMEAIQAQREEERTQAESAL---CQMQLETEKERV 928
Query: 680 CSCKCPLLGKVWEAD----LEACR--LLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIP 733
+ L + AD LE R + +Q L+ QE G L + + +L+ AA
Sbjct: 929 SLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA---- 984
Query: 734 PRLHSEDKRKTPLKESYIL--SAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQS--- 788
R H +D + S +L +L ++ ED+ +L+ +D E L ++
Sbjct: 985 -RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043
Query: 789 --LRRELQMVKETL-------QAMILQLQPAKEAGEREAAASCMTAGVHEAQ 831
+++EL+ K +L + +L LQ A ++E +A + + EAQ
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA--LRQDMQEAQ 1093
Score = 47.0 bits (110), Expect = 7e-05
Identities = 114/514 (22%), Positives = 206/514 (40%), Gaps = 46/514 (8%)
Query: 345 RRQMEVISLRLKLQKLQEDAVE---NDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPA 400
R +ME + +RLK Q+ + +A++ ++ +AE+ L Q + E+E++SL L Q
Sbjct: 882 REKME-LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 401 LSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ---DSLHVSITRRDW 457
L+ L Q + +Q + T L+ R L+ A+ D L
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS 1000
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQ----------EQQLQWQGCDLT-- 505
LLQ+K LQK++E L++++ + + + +E++E+ +++L+ + LT
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 506 PLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVC 565
+ + L LQE Q L++ Q A+ + + L +++ L +KE
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQ--KELSAQMELLRQEVKEKEADFL 1118
Query: 566 MSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSERE--GLEG 623
E + + E QL A L A+ A + + ++ +L +E++
Sbjct: 1119 AQEAQLLEELEASHITEQQLRASLWAQ-EAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
Query: 624 LLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYM--------ETL 675
++L L S + LGSV E L + + + +N + +
Sbjct: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
Query: 676 KNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPR 735
+ S L +W+ L Q +L+E E + +L+ +
Sbjct: 1238 AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ- 1296
Query: 736 LHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQM 795
+ E+K K K++ L +EL E E + L+ +L A E Q R LQ
Sbjct: 1297 -NQEEKSKWEGKQN-SLESELMELHETMAS----LQSRLRRAELQRME--AQGERELLQA 1348
Query: 796 VKETLQAMILQLQPAKEAGEREAAASCMTAGVHE 829
KE L A + LQ A EA A AG+ E
Sbjct: 1349 AKENLTAQVEHLQ----AAVVEARAQASAAGILE 1378
Score = 44.3 bits (103), Expect = 5e-04
Identities = 106/518 (20%), Positives = 208/518 (40%), Gaps = 90/518 (17%)
Query: 338 RDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSR 397
++ L+R + +EV +LQ AVE D D AE LQ E + SL F+ +
Sbjct: 731 KEALVREKAALEV--------RLQ--AVERDRQDLAEQLQGLSSAKELLESSL-FEAQQQ 779
Query: 398 QPALSSFLGHLAAQVQAALRRGATQQASGD--------DTHTPLRMEPR----------- 438
+ G L Q+Q + A + G+ DT + R
Sbjct: 780 NSVIEVTKGQLEVQIQTVTQ--AKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
Query: 439 ------LLEPTAQDSLHVSITRRDWLLQE---KQQLQKEIEALQARMFVLEAKDQQLRRE 489
L + A V+ R W + +Q+L K +E+L+ LE + ++ + E
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Query: 490 IEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQER 549
+E + Q + + + Q+ L +E L+ L + ++ A+ + + L++
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL---ADASQQLERLRQD 954
Query: 550 IKSLNLSLKEITTKVCMS--EKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDL 607
+K L +E TT + + ++ L++ L AL E S + DL
Sbjct: 955 MKVQKLKEQE-TTGILQTQLQEAQRELKEAARQHRDDLAALQEE-----SSSLLQDKMDL 1008
Query: 608 TEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKEN 667
+++ L S+ + S+ LV + V++ ++YNR+++E+E ++ + S+ E
Sbjct: 1009 QKQVEDLKSQLVAQDD--SQRLV--EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 668 TMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEG 727
+ + + + + +L A R +QEA+G E QM+ L
Sbjct: 1065 EQRLLVLQE----------ADSIRQQELSALR-----QDMQEAQGE-QKELSAQMELL-- 1106
Query: 728 AAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQ 787
+++ KE+ L+ E + E++ + E QL ++ + + Q
Sbjct: 1107 -------------RQEVKEKEADFLAQE-AQLLEELEASHI-TEQQLRASLWAQEAKAAQ 1151
Query: 788 SLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTA 825
L+ L+ + L+A+ + QP +A + AS +A
Sbjct: 1152 -LQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Score = 40.8 bits (94), Expect = 0.005
Identities = 79/372 (21%), Positives = 157/372 (42%), Gaps = 56/372 (15%)
Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQ---LQWQGCDLTPLVGQL 511
RD L + LQ E+++L +L+ ++LR+++E EQ+ L+ +L L G
Sbjct: 444 RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGDS 502
Query: 512 SLGQLQEVSKALQDTLASAGQIP-----FHAEPPETIR---SLQERIKSLNL-------S 556
+ GQ +E + L + ++ A+ E++ +L+E ++S +L
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Query: 557 LKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTS 616
E+T + +E+ + L N ++T++ L A A L+ +L
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAA------------AVKLSALNEALAL 610
Query: 617 EREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK 676
++ GL L +L + ++ + ++ N L+ ++ E E ++NT ++E
Sbjct: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNT--HLEAQL 668
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRL 736
K G +ADL +QE + + + E A + +L
Sbjct: 669 Q-----KAEEAGAELQADLR---------DIQEEKEEIQKKLSESRHQQEAATTQL-EQL 713
Query: 737 HSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMV 796
H E KR + +L+ + EK E + ++ LE +L A+ +DL + L + L
Sbjct: 714 HQEAKR-----QEEVLARAVQEK-EALVREKAALEVRLQ-AVERDRQDLAEQL-QGLSSA 765
Query: 797 KETLQAMILQLQ 808
KE L++ + + Q
Sbjct: 766 KELLESSLFEAQ 777
Score = 38.9 bits (89), Expect = 0.020
Identities = 86/452 (19%), Positives = 186/452 (41%), Gaps = 84/452 (18%)
Query: 376 LQQRLEDLEQEKISLHFQLPSRQPALSSF---LGHLAAQVQAALRRGATQQASGDDTHTP 432
LQ+ + LEQ+ LH ++ LS + L Q+Q A +G ++ S
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS------- 1800
Query: 433 LRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEE 492
++ +L E AQ +L + L QE+QQ Q + E ++ + L+ +Q ++E
Sbjct: 1801 --LQSQLDE--AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 493 QEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKS 552
+ +LQ +E ++ L++ LA G+ +++L+E +
Sbjct: 1857 RHGELQ----------------DHKEQARRLEEELAVEGR---------RVQALEEVLGD 1891
Query: 553 LNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIR 612
L +E + ++ C+ ++ + E + AL ++ + A + K+ +E+
Sbjct: 1892 LRAESREQEKALLALQQQCA---EQAQEHEVETRALQDSWLQAQA-----VLKERDQELE 1943
Query: 613 SLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYM 672
+L +E + SSR+ +E+ R R E + + + K
Sbjct: 1944 ALRAESQ------------SSRH-------QEEAARARAEALQEALGKAHAALQG--KEQ 1982
Query: 673 ETLKNKLCSCKCPLLGKVWEADLEAC----RLLIQSLQLQEARGSLSVEDERQMDDLEGA 728
L+ S +A L+AC R L ++L++QE G + +D R +D++
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE--GEIQDQDLRYQEDVQQL 2040
Query: 729 APPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDL--I 786
+ R +++ + + +L L ++ ++ ++++ + +E++ +
Sbjct: 2041 QQALAQR---DEELRHQQEREQLLEKSLAQRVQE-----NMIQEKQNLGQEREEEEIRGL 2092
Query: 787 QSLRRELQMVKETLQAMILQLQPAKEAGEREA 818
RELQ+ + IL+L+ ++ EA
Sbjct: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLEA 2124
Score = 37.0 bits (84), Expect = 0.075
Identities = 117/544 (21%), Positives = 221/544 (40%), Gaps = 100/544 (18%)
Query: 346 RQMEVISLRLKLQKL------QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQP 399
R+ EV +LR ++Q+L Q+ A+E D + Q+ DL+QE+I
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE--VDLQQEQIQ-------ELE 1483
Query: 400 ALSSFLGHLAAQVQA-----ALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITR 454
S L HL VQ ++R ++ D +E +LLE +D + S +
Sbjct: 1484 KCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES--Q 1541
Query: 455 RDWLLQEKQQL--------------------QKEIEALQARMFVLEAKDQQLRREIEEQE 494
R + K+QL QK I+ L+ + L ++EE+
Sbjct: 1542 RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERS 1601
Query: 495 QQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLN 554
Q+LQ Q + L ++ +++ LQ E + ++S +E+I+ L
Sbjct: 1602 QELQAQSSQIHDLESHSTV-----LARELQ-------------ERDQEVKSQREQIEELQ 1643
Query: 555 LSLKEITTKVCMSEKFCSTLRKKVNDIE---TQLPALLEAKMHAISGNHFWTAKDLTEEI 611
+ +T + ++ ++++ +E T+ +LE + I L E
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK-------LSLRERG 1696
Query: 612 RSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVE-HQETAYE-TSVKENTM 669
R LT++R+ ++ + S L +K +EVE QE +E +K+
Sbjct: 1697 RELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE 1756
Query: 670 KYMETLKNKLCSCKCPLLGK-----VWEADLEACR----LLIQSL--QLQEARGSLSVED 718
+ ++ L K+ L + V + L+ R L QSL QL EA+ +L+ D
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
Query: 719 ------ERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLED 772
+++ +G + + D + L+++++ E + +D ++ LE+
Sbjct: 1817 QELEALQQEQQQAQGQEERVKEK---ADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873
Query: 773 QLHTAIHSHD----EDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVH 828
+L A+ E+++ LR E + ++ L A LQ Q A++A E E +
Sbjct: 1874 EL--AVEGRRVQALEEVLGDLRAESREQEKALLA--LQQQCAEQAQEHEVETRALQDSWL 1929
Query: 829 EAQA 832
+AQA
Sbjct: 1930 QAQA 1933
Score = 32.0 bits (71), Expect = 2.4
Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 43/191 (22%)
Query: 338 RDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSR 397
RD LR++++ E + + Q++QE+ ++ E ++ + L Q L L +
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Query: 398 QPALSSFLGHLAAQVQAALRRGATQQASGDD----THTPLRMEPRLLEPTAQDSLHVSIT 453
+ Q L TQQ + + +H ME + L+ DSL
Sbjct: 2107 E--------------QEILELRETQQRNNLEALPHSHKTSPMEEQSLK---LDSL----- 2144
Query: 454 RRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSL 513
+ +LQ+E+E LQA + EA REIE +E+ Q L+ + S+
Sbjct: 2145 --------EPRLQRELERLQAALRQTEA------REIEWREKA---QDLALSLAQTKASV 2187
Query: 514 GQLQEVSKALQ 524
LQEV+ LQ
Sbjct: 2188 SSLQEVAMFLQ 2198
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.8 bits (133), Expect = 2e-07
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 62/364 (17%)
Query: 482 KDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPE 541
K + R+E+EE+ L + DL V Q L + + + + Q+
Sbjct: 867 KSEARRKELEEKMVSLLQEKNDLQLQV-QAEQDNLNDAEERCDQLIKNKIQLE------A 919
Query: 542 TIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHF 601
++ + ER++ E+T K E CS L+K ++D+E L A +E + HA
Sbjct: 920 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTL-AKVEKEKHATE---- 974
Query: 602 WTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYE 661
++++LT E GL+ +++KL K+ +++E HQ+ +
Sbjct: 975 -------NKVKNLTEEMAGLDEIIAKL-------TKEKKALQE---------AHQQALDD 1011
Query: 662 TSVKENTMKYMETLKNKLCSCKCPLLG-----KVWEADLEACRLLIQSLQLQEARGSLSV 716
V+E+ + + K KL L G K DLE + ++ G L +
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAK--------RKLEGDLKL 1063
Query: 717 EDERQMDDLEGAAPPIPPRLHSED----KRKTPLKESYILSAELGEKCEDIGKKLLYLED 772
E M DLE + +L ++ ++ + +++ +L+ +L +K ++ ++ LE+
Sbjct: 1064 TQESIM-DLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEE 1122
Query: 773 QLHT--AIHSHDEDLIQSLRRELQMVKETLQ----AMILQLQPAKEAGEREAAASCMTAG 826
+L + E L L REL+ + E L+ A +Q++ K +REA M
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK---KREAEFQKMRRD 1179
Query: 827 VHEA 830
+ EA
Sbjct: 1180 LEEA 1183
Score = 43.1 bits (100), Expect = 0.001
Identities = 66/390 (16%), Positives = 159/390 (40%), Gaps = 38/390 (9%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++ +EA+ A+ LE +L+ EIE+ ++ + L
Sbjct: 1395 LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA---------AAAALD 1445
Query: 518 EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
+ + LA Q + E + S Q+ +SL+ L ++ S + T +++
Sbjct: 1446 KKQRNFDKILAEWKQ--KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503
Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
+++ ++ L E H +L + + L E+ L+ L +
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVH-----ELEKVRKQLEVEKLELQSALEEAEASLEHEEG 1558
Query: 638 KLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSCKC 684
K+ + ++N+++ E+E + + + K N + +++L +N++ K
Sbjct: 1559 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKK 1618
Query: 685 PLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ G + E +++ A R+ ++ + ++ SL + + Q+DD A + + ++
Sbjct: 1619 KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1678
Query: 742 RKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRRELQM 795
R L+ E E E+ + ++ L + +HS + LI + + +L
Sbjct: 1679 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQ 1738
Query: 796 VKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ + + + A+E ++ + M A
Sbjct: 1739 LQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Score = 40.8 bits (94), Expect = 0.005
Identities = 89/399 (22%), Positives = 170/399 (42%), Gaps = 52/399 (13%)
Query: 445 QDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQL---RREIEEQEQQLQWQG 501
QD+L+ + R D L++ K QL+ +++ + R+ E + +L +R++E++ +L+
Sbjct: 897 QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI 956
Query: 502 CDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEIT 561
DL + ++ + +K T AG A+ + ++LQE + L+
Sbjct: 957 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEE 1016
Query: 562 TKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSE---- 617
KV K L ++V+D+E L + +M DL R L +
Sbjct: 1017 DKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM------------DLERAKRKLEGDLKLT 1064
Query: 618 REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQET---AYETSVKENTMKYMET 674
+E + L + L L + KK + D N+ ++E ++ + +KEN + +E
Sbjct: 1065 QESIMDLENDKLQLEEKLKKK----EFDINQQNSKIEDEQVLALQLQKKLKENQAR-IEE 1119
Query: 675 LKNKLCSCKCPLLGKVWEADLEACRLLIQ-SLQLQEARGSLSV----------EDERQMD 723
L+ +L + KV + + R L + S +L+EA G+ SV E ++
Sbjct: 1120 LEEEL-EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Query: 724 DLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLH------TA 777
DLE A L E K+ AELGE+ +++ + LE +
Sbjct: 1179 DLEEAT------LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Query: 778 IHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGER 816
+ S+ E +I++ + L+ V TL+ + + E +R
Sbjct: 1233 VTSNMEQIIKA-KANLEKVSRTLEDQANEYRVKLEEAQR 1270
Score = 37.7 bits (86), Expect = 0.044
Identities = 116/550 (21%), Positives = 218/550 (39%), Gaps = 111/550 (20%)
Query: 349 EVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHL 408
E+I+ K +K ++A D + + ++ L + K+ L Q+ + +L +
Sbjct: 989 EIIAKLTKEKKALQEA-HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEK-KV 1046
Query: 409 AAQVQAALRR-----GATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ 463
++ A R+ TQ++ D + L++E +L + I +++ ++++Q
Sbjct: 1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK------EFDINQQNSKIEDEQ 1100
Query: 464 ----QLQKEIEALQARMFVLE----------AKDQQLR----REIEEQEQQLQWQGCDLT 505
QLQK+++ QAR+ LE AK ++LR RE+EE ++L+ G T
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GAT 1159
Query: 506 PLVGQLSLGQLQEVSK--------ALQDTLASAGQIPFH----AEPPETIRSLQ------ 547
+ +++ + E K LQ +A H AE E I +LQ
Sbjct: 1160 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 548 ERIKS-LNLSLKEITTKV-------CMSEKFCSTLRKKVNDIETQLP---------ALLE 590
E+ KS L L ++T+ + EK TL + N+ +L
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 591 AKMHAISGNHFWTAKD-------LTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVK 643
AK+ +G ++ LT S T + E L+ L + + L S +
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Query: 644 EDYNRLRREVEHQ---------------------ETAYETSVKENTMKYMETLKNKLCSC 682
D + LR + E + T YET + T + +E K KL
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQ- 1397
Query: 683 KCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLE---GAAPPIPPRLHSE 739
++ +A+ + + L++ + L E E M D+E AA + + +
Sbjct: 1398 ------RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF 1451
Query: 740 DKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDL--IQSLRRELQMVK 797
DK K+ Y E + E K+ L +L ++++E L +++ +RE + ++
Sbjct: 1452 DKILAEWKQKY---EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508
Query: 798 ETLQAMILQL 807
E + + QL
Sbjct: 1509 EEISDLTEQL 1518
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 55.5 bits (132), Expect = 2e-07
Identities = 105/491 (21%), Positives = 206/491 (41%), Gaps = 66/491 (13%)
Query: 339 DCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
D L++ + Q+E K++++ E A + ++ + T ++R LE E L + +
Sbjct: 907 DQLIKAKFQLEA-----KIKEVTERAEDEEEINAELTAKKR--KLEDECSELKKDIDDLE 959
Query: 399 PALSSFLGHLAAQVQAALRRGATQQASG-DDTHTPLRMEPRLLEPTAQ---DSLHVSITR 454
L+ A + T++ SG D+T L E + L+ Q D L +
Sbjct: 960 LTLAKVEKEKHATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLG 514
+ L + K +L++++E L++ + ++++LR ++E +++L+ DL + Q S+
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEG---DLK--LAQESIL 1068
Query: 515 QLQEVSKALQDTLASAG----QIPFHAEPPETIR-SLQERIKSLNLSLKEITTKVCMSEK 569
L+ + L + L Q+ E +T+ Q++IK L ++E+ ++
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHA--ISGNHFWTAKDLTEEIRSLTSEREGL----EG 623
+ K+ +D +L L E A ++ K E L + E E
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 624 LLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSV-------------KENTMK 670
+++ L + +V +LG ++ R+++++E +++ ++ + K N K
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 671 YMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAP 730
TL+++L + GK E L Q +LQ G LS RQ+++ E
Sbjct: 1249 ICRTLEDQLSEAR----GKNEEIQRSLSELTTQKSRLQTEAGELS----RQLEEKES--- 1297
Query: 731 PIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLR 790
I +L + T E EL + E+ K L L ++ HD DL++
Sbjct: 1298 -IVSQLSRSKQAFTQQTE------ELKRQLEEENKAKNALAHALQSS--RHDCDLLREQY 1348
Query: 791 RELQMVKETLQ 801
E Q K LQ
Sbjct: 1349 EEEQEGKAELQ 1359
Score = 54.3 bits (129), Expect = 5e-07
Identities = 96/396 (24%), Positives = 163/396 (41%), Gaps = 68/396 (17%)
Query: 462 KQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSK 521
K++ QK + L AK + R+E+EE+ L + DL QL Q+Q S+
Sbjct: 854 KEEFQKTKDEL--------AKSEAKRKELEEKLVTLVQEKNDL-----QL---QVQAESE 897
Query: 522 ALQDTLASAGQI---PFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
L D Q+ F E I+ + ER + E+T K E CS L+K +
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAK--IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEE-------IRSLTSEREGLEGLLSKLLVL 631
+D+E L A +E + HA K+LTEE I LT E++ L+ + L
Sbjct: 956 DDLELTL-AKVEKEKHATENK----VKNLTEELSGLDETIAKLTREKKALQEAHQQALDD 1010
Query: 632 SSRNVKKLGSVKEDYNRLRREVEHQETAYETSVK------------ENTMKYMETLKNKL 679
K+ S+ + ++L ++VE E++ E K E +K + L
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDL 1070
Query: 680 CSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSE 739
+ K L ++ + D E C+L + E +L ++ ++++ +L+ + + +E
Sbjct: 1071 ENDKQQLDERLKKKDFEYCQLQSK----VEDEQTLGLQFQKKIKELQARIEELEEEIEAE 1126
Query: 740 --DKRKTPLKESYILS--AELGEKCEDIG--------------KKLLYLEDQLHTAIHSH 781
+ KT + S EL E+ E+ G + L L L A H
Sbjct: 1127 RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186
Query: 782 DEDLIQSLRRELQMVKETLQAMILQLQPAKEAGERE 817
E ++ +LR++ L I LQ K+ E+E
Sbjct: 1187 -EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221
Score = 37.4 bits (85), Expect = 0.058
Identities = 76/380 (20%), Positives = 153/380 (40%), Gaps = 43/380 (11%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++++EA+ A+ LE Q+L+ E+E+ ++ L L Q +
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE----RANSLAAALDKKQ-R 1448
Query: 518 EVSKALQD--TLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLR 575
K L + T Q A E+ RSL + L + +E ++ ++ L
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKES-RSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507
Query: 576 KKVNDIETQLPA------LLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
+++ D+ Q+ LE I L E +L E + + +L
Sbjct: 1508 QEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELT 1567
Query: 630 VLSSRNVKKLGSVKEDYNRLRRE----VEHQETAYETSVKENTMKYMETLKNKLCSCKCP 685
+ S +K+ E+ +L+R VE ++A + V+ +N+ K
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRS---------RNEAIRLKKK 1618
Query: 686 LLGKVWEADLE---ACRLLIQSLQ-LQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ G + E +++ A R ++L+ L+ +G L + + +DD + +L ++
Sbjct: 1619 MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK-DTQLHLDDALRGQEDLKEQLAIVER 1677
Query: 742 RKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKE 798
R L+ E + E E+ + ++ L ++ +H+ + LI + K+
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHT--------KK 1729
Query: 799 TLQAMILQLQPAKEAGEREA 818
L+ ++QLQ E R+A
Sbjct: 1730 KLETDLMQLQSEVEDASRDA 1749
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 55.5 bits (132), Expect = 2e-07
Identities = 90/388 (23%), Positives = 166/388 (42%), Gaps = 70/388 (18%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
+E +++E E + + EAK R+E+EE+ L + DL QLQ
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAK----RKELEEKMVTLMQEKNDL----------QLQVQ 896
Query: 520 SKALQDTLASAGQ-----IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTL 574
++A D+LA A + I + I+ + ER + E+T K E CS L
Sbjct: 897 AEA--DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 575 RKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSR 634
+K ++D+E L A +E + HA ++++LT E GL+ ++KL
Sbjct: 955 KKDIDDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDETIAKL------ 996
Query: 635 NVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEAD 694
K+ +++E HQ+T + +E+ + + K KL L E
Sbjct: 997 -TKEKKALQE---------AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL-----EGS 1041
Query: 695 LEACRLLIQSLQ--LQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKR----KTPLKE 748
LE + + L+ ++ G L + E M D+E + +L ++ ++ +++
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTM-DIENDKQQLDEKLKKKEFEMSGLQSKIED 1100
Query: 749 SYILSAELGEKCEDIGKKLLYLEDQLHT--AIHSHDEDLIQSLRRELQMVKETLQ----A 802
L +L +K +++ ++ LE+++ A + E L REL+ + E L+ A
Sbjct: 1101 EQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160
Query: 803 MILQLQPAKEAGEREAAASCMTAGVHEA 830
Q++ K +REA M + EA
Sbjct: 1161 TSAQIEMNK---KREAEFQKMRRDLEEA 1185
Score = 42.4 bits (98), Expect = 0.002
Identities = 74/419 (17%), Positives = 180/419 (42%), Gaps = 57/419 (13%)
Query: 357 LQKLQEDAVENDDYDKAET-LQQRLEDLE-----QEKISLHFQLPSRQPALSSFLGHLAA 410
L LQ + + + KA+ L+Q+++DLE ++KI + + R+
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK-----------L 1059
Query: 411 QVQAALRRGATQQASGDDTHTPLRMEPRLLEPTA-------QDSLHVSITRRDWLLQEK- 462
+ L + +T D +++ + E + + +L + + ++ LQ +
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 463 QQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV--GQLSLGQLQEVS 520
++L++EIEA +A E + L RE+EE ++L+ G + + + + Q++
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 521 KALQDTLA--SAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
+ L++ A + +++ L E+I +L +++ EK S ++ ++
Sbjct: 1180 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL-------EKEKSEMKMEI 1232
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
+D+ + + + +AK GN + L +++ + ++ E + L++ L +R +
Sbjct: 1233 DDLASNMETVSKAK-----GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287
Query: 639 LGSVK---EDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSC--------KCPLL 687
G ++ + L ++ + A+ ++E + E +K K C LL
Sbjct: 1288 SGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL 1347
Query: 688 GKVWEADLEACRLLIQSL-----QLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ +E + EA L +++ ++ + R + ++ ++LE A + RL ++
Sbjct: 1348 REQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
Score = 39.7 bits (91), Expect = 0.012
Identities = 67/392 (17%), Positives = 161/392 (41%), Gaps = 42/392 (10%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++ +EA+ A+ LE Q+L+ E+E+ ++ + L
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA---------ACAALD 1447
Query: 518 EVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLR 575
+ + LA Q HAE + + Q+ +SL+ L +I S TL+
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAE----LEASQKESRSLSTELFKIKNAYEESLDQLETLK 1503
Query: 576 KKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRN 635
++ +++ ++ L E H +L + + + E+ L+ L +
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIH-----ELEKIKKQVEQEKSELQAALEEAEASLEHE 1558
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSC 682
K+ ++ + N+++ EV+ + + + K N ++ +E++ +N
Sbjct: 1559 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 683 KCPLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSE 739
K + G + E +++ A R+ ++L+ ++ + + +DD + + +L
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678
Query: 740 DKRKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRREL 793
++R L+ E + E E+ I ++ L + +H+ + LI + L ++
Sbjct: 1679 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1738
Query: 794 QMVKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ +I + + A+E ++ + M A
Sbjct: 1739 SQIQGEMEDIIQEARNAEEKAKKAITDAAMMA 1770
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 54.7 bits (130), Expect = 3e-07
Identities = 101/427 (23%), Positives = 175/427 (40%), Gaps = 64/427 (14%)
Query: 451 SITRRDWLLQEKQQLQKEIE----------ALQARMFVLEAKDQQLRREIEEQEQQ---- 496
S+ +++ L+++Q + E+E + +A L+A+ Q+L+ +EE +QQ
Sbjct: 278 SLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLA 337
Query: 497 ----------LQWQGCDLTPLVGQLSLGQLQEVSKA-----LQDTLASAGQIPFHAEPPE 541
GC L +L G L + KA LQ L + AE +
Sbjct: 338 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQ 397
Query: 542 TIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHF 601
T S ++R++ L+L L E K+ S+K L+K V + + ++ +L+ H
Sbjct: 398 T--SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS 455
Query: 602 WTAK---DLTEEIRSLTSEREGL----------EGLLSKLLVLSSRNVKKL----GSVKE 644
K DL E + L +RE L EG L L + K L ++E
Sbjct: 456 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 515
Query: 645 DYNRLRREVEHQETAYETSV-KENT-MKYMETLKNKLCSCKCPLLGKVWEAD--LEACRL 700
+ LR E++ T E+S+ K NT + ++ L ++ K L+ + D L+ +
Sbjct: 516 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 575
Query: 701 LIQSLQLQEARGSLSVEDERQMDDLEGA----------APPIPPRLHSEDKRKTPLKESY 750
+Q+ +EA +LS + DDL A + L ++K L+E
Sbjct: 576 YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 635
Query: 751 ILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPA 810
I E +K +KL + +H+ D+ L + + LQ K+ L++ A
Sbjct: 636 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQ--HQNDLKMLAA 693
Query: 811 KEAGERE 817
KE RE
Sbjct: 694 KEEQLRE 700
Score = 30.4 bits (67), Expect = 7.1
Identities = 17/43 (39%), Positives = 29/43 (67%), Gaps = 2/43 (4%)
Query: 758 EKCEDIGKKLLYLEDQLHT-AIHSHD-EDLIQSLRRELQMVKE 798
E+CEDI K L +L++Q + +H + ++L++ LR EL+ V E
Sbjct: 154 EECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 196
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 54.7 bits (130), Expect = 3e-07
Identities = 101/427 (23%), Positives = 175/427 (40%), Gaps = 64/427 (14%)
Query: 451 SITRRDWLLQEKQQLQKEIE----------ALQARMFVLEAKDQQLRREIEEQEQQ---- 496
S+ +++ L+++Q + E+E + +A L+A+ Q+L+ +EE +QQ
Sbjct: 423 SLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLA 482
Query: 497 ----------LQWQGCDLTPLVGQLSLGQLQEVSKA-----LQDTLASAGQIPFHAEPPE 541
GC L +L G L + KA LQ L + AE +
Sbjct: 483 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQ 542
Query: 542 TIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHF 601
T S ++R++ L+L L E K+ S+K L+K V + + ++ +L+ H
Sbjct: 543 T--SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS 600
Query: 602 WTAK---DLTEEIRSLTSEREGL----------EGLLSKLLVLSSRNVKKL----GSVKE 644
K DL E + L +RE L EG L L + K L ++E
Sbjct: 601 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 660
Query: 645 DYNRLRREVEHQETAYETSV-KENT-MKYMETLKNKLCSCKCPLLGKVWEAD--LEACRL 700
+ LR E++ T E+S+ K NT + ++ L ++ K L+ + D L+ +
Sbjct: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 720
Query: 701 LIQSLQLQEARGSLSVEDERQMDDLEGA----------APPIPPRLHSEDKRKTPLKESY 750
+Q+ +EA +LS + DDL A + L ++K L+E
Sbjct: 721 YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 780
Query: 751 ILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPA 810
I E +K +KL + +H+ D+ L + + LQ K+ L++ A
Sbjct: 781 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQ--HQNDLKMLAA 838
Query: 811 KEAGERE 817
KE RE
Sbjct: 839 KEEQLRE 845
Score = 30.8 bits (68), Expect = 5.4
Identities = 68/300 (22%), Positives = 122/300 (40%), Gaps = 46/300 (15%)
Query: 510 QLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
Q L QLQ++ K L L ++ FH E +T + +S+ L++ T+ + +
Sbjct: 77 QCHLRQLQQLKKKL---LVLQQELEFHTEELQTSYYSLRQYQSI---LEKQTSDLVLLHH 130
Query: 570 FCSTLRKKVNDIETQLPALLE---AKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLS 626
C +V E ++ E K+H + RSL R+ + LS
Sbjct: 131 HCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLS 190
Query: 627 KLLVLSSRNVK----KLGSV--KEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLC 680
+ +L + VK +LG + +E N+ +H + TS ++ ET K
Sbjct: 191 NIELLECQ-VKMLQGELGGIMGQEPENK----GDHSKVRIYTSPCM-IQEHQETQKR--- 241
Query: 681 SCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED 740
L +VW+ + L+ + +L +E E+ + L+ D
Sbjct: 242 ------LSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQA------------D 283
Query: 741 KRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHT-AIHSHD-EDLIQSLRRELQMVKE 798
Y S+ E+CEDI K L +L++Q + +H + ++L++ LR EL+ V E
Sbjct: 284 FASCTATHRYPPSSS--EECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 341
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 53.9 bits (128), Expect = 6e-07
Identities = 89/384 (23%), Positives = 165/384 (42%), Gaps = 62/384 (16%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
+E +++E + ++ + EAK R+E+EE+ L + DL QL Q+Q
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAK----RKELEEKMVTLLKEKNDL-----QL---QVQAE 900
Query: 520 SKALQDTLASAGQ-IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
++ L D Q I + I+ + ER + E+T K E CS L+K +
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
+D+E L A +E + HA ++++LT E GL+ ++KL K+
Sbjct: 961 DDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDETIAKL-------TKE 1001
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEAC 698
+++E HQ+T + +E+ + + K KL L E LE
Sbjct: 1002 KKALQE---------AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL-----EGSLEQE 1047
Query: 699 RLLIQSLQ--LQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED----KRKTPLKESYIL 752
+ L L+ ++ G L + E M D+E + +L ++ ++ +++ L
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIM-DIENEKQQLDEKLKKKEFEISNLQSKIEDEQAL 1106
Query: 753 SAELGEKCEDIGKKLLYLEDQLHT--AIHSHDEDLIQSLRRELQMVKETLQ----AMILQ 806
+L +K +++ ++ LE+++ A + E L REL+ + E L+ A Q
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1166
Query: 807 LQPAKEAGEREAAASCMTAGVHEA 830
++ K +REA M + EA
Sbjct: 1167 IEMNK---KREAEFQKMRRDLEEA 1187
Score = 43.9 bits (102), Expect = 6e-04
Identities = 83/413 (20%), Positives = 181/413 (43%), Gaps = 45/413 (10%)
Query: 357 LQKLQEDAVENDDYDKAET-LQQRLEDLE----QEKISLHFQLPSRQPALSSFLGHLAAQ 411
L LQ + + + KA+ L+Q+++DLE QEK L L + L L
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK-KLRMDLERAKRKLEGDL----KL 1067
Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD--SLHVSITRRDWLLQEK-QQLQKE 468
Q ++ ++ D+ E L+ +D +L + + ++ LQ + ++L++E
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE 1127
Query: 469 IEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV--GQLSLGQLQEVSKALQDT 526
IEA +A E + L RE+EE ++L+ G + + + + Q++ + L++
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA 1187
Query: 527 LA--SAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQ 584
A + +++ L E+I +L +++ EK S ++ +++D+ +
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL-------EKEKSEMKMEIDDLASN 1240
Query: 585 LPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVK- 643
+ + +AK GN + L +++ L S+ E + L++ L R + G
Sbjct: 1241 VETVSKAK-----GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 644 --EDYNRLRREVEHQETAYETSVKENTMKYMETLKNK------LCSCK--CPLLGKVWEA 693
++ L ++ + A+ ++E + E +K K L S + C LL + +E
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 694 DLEACRLLIQSL-----QLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ E+ L ++L ++ + R + ++ ++LE A + RL + ++
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Score = 35.8 bits (81), Expect = 0.17
Identities = 66/392 (16%), Positives = 159/392 (40%), Gaps = 42/392 (10%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++ +EA+ A+ LE Q+L+ E+E+ ++ + L
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA---------ACAALD 1449
Query: 518 EVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLR 575
+ + LA Q HAE + + Q+ +SL L +I S TL+
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAE----LEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 576 KKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRN 635
++ +++ ++ L E H +L + + + E+ L+ L +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIH-----ELEKIKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSC 682
K+ ++ + N+++ EV+ + + + K N ++ +E++ +N
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 683 KCPLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSE 739
K + G + E +++ A R+ ++L+ + + + +DD + + +L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 740 DKRKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRREL 793
++R L+ E + E E+ I ++ L + +H+ + LI + L ++
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 794 QMVKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ ++ + + A+E ++ + M A
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 53.9 bits (128), Expect = 6e-07
Identities = 89/384 (23%), Positives = 165/384 (42%), Gaps = 62/384 (16%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
+E +++E + ++ + EAK R+E+EE+ L + DL QL Q+Q
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAK----RKELEEKMVTLLKEKNDL-----QL---QVQAE 900
Query: 520 SKALQDTLASAGQ-IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
++ L D Q I + I+ + ER + E+T K E CS L+K +
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
+D+E L A +E + HA ++++LT E GL+ ++KL K+
Sbjct: 961 DDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDETIAKL-------TKE 1001
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEAC 698
+++E HQ+T + +E+ + + K KL L E LE
Sbjct: 1002 KKALQE---------AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL-----EGSLEQE 1047
Query: 699 RLLIQSLQ--LQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED----KRKTPLKESYIL 752
+ L L+ ++ G L + E M D+E + +L ++ ++ +++ L
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIM-DIENEKQQLDEKLKKKEFEISNLQSKIEDEQAL 1106
Query: 753 SAELGEKCEDIGKKLLYLEDQLHT--AIHSHDEDLIQSLRRELQMVKETLQ----AMILQ 806
+L +K +++ ++ LE+++ A + E L REL+ + E L+ A Q
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1166
Query: 807 LQPAKEAGEREAAASCMTAGVHEA 830
++ K +REA M + EA
Sbjct: 1167 IEMNK---KREAEFQKMRRDLEEA 1187
Score = 43.9 bits (102), Expect = 6e-04
Identities = 83/413 (20%), Positives = 181/413 (43%), Gaps = 45/413 (10%)
Query: 357 LQKLQEDAVENDDYDKAET-LQQRLEDLE----QEKISLHFQLPSRQPALSSFLGHLAAQ 411
L LQ + + + KA+ L+Q+++DLE QEK L L + L L
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK-KLRMDLERAKRKLEGDL----KL 1067
Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD--SLHVSITRRDWLLQEK-QQLQKE 468
Q ++ ++ D+ E L+ +D +L + + ++ LQ + ++L++E
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE 1127
Query: 469 IEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV--GQLSLGQLQEVSKALQDT 526
IEA +A E + L RE+EE ++L+ G + + + + Q++ + L++
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA 1187
Query: 527 LA--SAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQ 584
A + +++ L E+I +L +++ EK S ++ +++D+ +
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL-------EKEKSEMKMEIDDLASN 1240
Query: 585 LPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVK- 643
+ + +AK GN + L +++ L S+ E + L++ L R + G
Sbjct: 1241 VETVSKAK-----GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 644 --EDYNRLRREVEHQETAYETSVKENTMKYMETLKNK------LCSCK--CPLLGKVWEA 693
++ L ++ + A+ ++E + E +K K L S + C LL + +E
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 694 DLEACRLLIQSL-----QLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ E+ L ++L ++ + R + ++ ++LE A + RL + ++
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Score = 35.8 bits (81), Expect = 0.17
Identities = 66/392 (16%), Positives = 159/392 (40%), Gaps = 42/392 (10%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q ++ +EA+ A+ LE Q+L+ E+E+ ++ + L
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA---------ACAALD 1449
Query: 518 EVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLR 575
+ + LA Q HAE + + Q+ +SL L +I S TL+
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAE----LEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 576 KKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRN 635
++ +++ ++ L E H +L + + + E+ L+ L +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIH-----ELEKIKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSC 682
K+ ++ + N+++ EV+ + + + K N ++ +E++ +N
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 683 KCPLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSE 739
K + G + E +++ A R+ ++L+ + + + +DD + + +L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 740 DKRKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRREL 793
++R L+ E + E E+ I ++ L + +H+ + LI + L ++
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 794 QMVKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ ++ + + A+E ++ + M A
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 53.5 bits (127), Expect = 8e-07
Identities = 94/410 (22%), Positives = 160/410 (39%), Gaps = 84/410 (20%)
Query: 458 LLQEKQQLQKEIEALQARMFV-------LEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQ 510
LL E ++L ++ + ++ LE +L++E + ++L++ CD L+
Sbjct: 1800 LLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL-- 1857
Query: 511 LSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKF 570
Q E S+ L L HA+ + + + +N S KE V E
Sbjct: 1858 ----QRVETSEGLNSDLE------MHADKSSR-EDIGDNVAKVNDSWKERFLDV---ENE 1903
Query: 571 CSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKD----------LTEEIRSLTSEREG 620
S +R + IE + LEA + + KD L EE+ +TSER
Sbjct: 1904 LSRIRSEKASIEHEA-LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
Query: 621 LEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQET-------AYETSVKENTMKYME 673
L G L + S+ L + E +E+E ++ E VKE T + ++
Sbjct: 1963 LRGELDTM----SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT-ELLQ 2017
Query: 674 TLK---NKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAP 730
TL ++L K L K+ + ++ L + +L+ L+ E E + + E
Sbjct: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES--- 2074
Query: 731 PIPPRLHSEDKRKTPLKESYILSAELGEK---------------------------CEDI 763
+ RL D K L S L A L EK E
Sbjct: 2075 -LQARLSESDYEK--LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Query: 764 GKKLLYLEDQLHTAIHSHD--EDLIQSLRRELQMVKETLQAMILQLQPAK 811
KK L++ ++L +D +D +++L RELQM +E + +IL + +K
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181
Score = 45.1 bits (105), Expect = 3e-04
Identities = 102/490 (20%), Positives = 193/490 (39%), Gaps = 76/490 (15%)
Query: 345 RRQMEVISLRLKLQKLQEDAVEND-DYDKAET----LQQRLEDLEQEKISLHFQLPSRQP 399
+ ++E+I L K +++ V YD+A T L+Q+L+ L ++ S +
Sbjct: 324 KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
Query: 400 ALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLL 459
+L + + Q L R + R + Q+ + + L
Sbjct: 384 SLEQKIKEKEKEFQEELSR-----------------QQRSFQTLDQECIQMKAR----LT 422
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
QE QQ + LQA + L + QQL +EE +Q+L C Q S + E+
Sbjct: 423 QELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL----CRAEQAF-QASQIKENEL 477
Query: 520 SKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVN 579
+++++ + H+E + L LK I + S+ F ++ K
Sbjct: 478 RRSMEEMKKENNLLKSHSE------QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 580 DIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKL 639
ET L L E K++ + T + L + L +R+ + LL K + KL
Sbjct: 532 SQETMLRDLQE-KIN--QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKL 588
Query: 640 GSVKEDYNRLRREVEHQETAYETSVKENTM-----KYMETLKNKLCSCKCPLLGKVWEAD 694
+++ L +E ++ YE +E T+ E L ++ S K L K+
Sbjct: 589 SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI--NH 646
Query: 695 LEACRLLIQSLQ----------LQEARGSLSVEDERQMDDLEGAAPPIPPRL-------- 736
LE C L Q ++ L+ R +LSVE + L+ + + +
Sbjct: 647 LETC-LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQ 705
Query: 737 ---HSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDED-LIQSLRRE 792
S+ K + ++ + +++L + ED+ KL L +++ D+D Q L E
Sbjct: 706 KAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI------MDKDRCYQDLHAE 759
Query: 793 LQMVKETLQA 802
+ +++ L++
Sbjct: 760 YESLRDLLKS 769
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/353 (19%), Positives = 145/353 (41%), Gaps = 53/353 (15%)
Query: 479 LEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAE 538
L+A++Q+LR +I E E +LQ ++ V + QLQ + KA + + E
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ-LEKAKVELI----------E 331
Query: 539 PPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISG 598
+ + ++ + + +TK E+ L+K D+ Q A+ ++
Sbjct: 332 KEKVLNKCRDELVRTTAQYDQASTKYTALEQ---KLKKLTEDLSCQRQNAESARC-SLEQ 387
Query: 599 NHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQET 658
K+ EE L+ ++ + L + + + +R ++L K +N L+ E++
Sbjct: 388 KIKEKEKEFQEE---LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL-- 442
Query: 659 AYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVED 718
TSVK+ +E K KLC + Q+ Q++E S+E+
Sbjct: 443 ---TSVKQQLENNLEEFKQKLCRAE----------------QAFQASQIKENELRRSMEE 483
Query: 719 ERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAI 778
++ ++L + HSE K +E L AEL + + + + E+ A
Sbjct: 484 MKKENNL--------LKSHSEQK----AREVCHLEAELKNIKQCLNQSQNFAEEM--KAK 529
Query: 779 HSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQ 831
++ E +++ L+ ++ + +L L+L A +R+ + + H +
Sbjct: 530 NTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIE 582
Score = 40.8 bits (94), Expect = 0.005
Identities = 96/484 (19%), Positives = 194/484 (40%), Gaps = 60/484 (12%)
Query: 374 ETLQQRLEDLEQEKISLHFQLPSRQ---PALSSFLGHLAAQVQAALRRGATQQASGDDTH 430
E L+ R+E E++++ + +L R+ +L + +L ++Q + +++
Sbjct: 2122 EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181
Query: 431 TPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREI 490
+ +E A+ SL V L EK+ L K+I+ Q ++ L+ + +
Sbjct: 2182 AEVETLKTQIEEMAR-SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL 2240
Query: 491 EEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKAL------QDTLASAGQIPFHAEPP-ETI 543
EE+E Q + Q + + ++ QL+E+++A+ Q+ + + Q +PP E
Sbjct: 2241 EEKE-QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ---SLDPPIEEE 2296
Query: 544 RSLQERIKSLNLSLKEITTK-VCM------SEKFCSTLRKKVNDIETQLPALLEAKMHAI 596
L+ I+ L L+ K +C+ SE L+ +V ++E +L + HA
Sbjct: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 597 --SGNHFWTAKDLTEEIRSLTSEREGLE----------GLLSKLLVLSSRNVKKLGSVKE 644
+ N + L +I +T GLE L+ L + +L +
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
Query: 645 DYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRL---- 700
+ + +E E + + +KE + ME L+ +L + D EAC+
Sbjct: 2417 SFENILQEKEQE----KVQMKEKSSTAMEMLQTQLKELNERV--AALHNDQEACKAKEQN 2470
Query: 701 ---LIQSLQLQEARGSLSVEDERQ-----MDDLEGAAPPI---PPRLHSEDKRKTPLKES 749
++ L+L++A+ +++ + + G + +L +D+ + LK
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 750 YILSAELGEKCEDI-GKKLLYLEDQLH----TAIHSHDEDLIQSLRRELQMVKETLQAMI 804
+L K + G+ L+ E L T ++QS LQ E LQ+
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY 2590
Query: 805 LQLQ 808
L+
Sbjct: 2591 KNLE 2594
Score = 40.4 bits (93), Expect = 0.007
Identities = 104/547 (19%), Positives = 208/547 (38%), Gaps = 85/547 (15%)
Query: 338 RDCL--LRNRRQMEVISLRLKLQKLQEDA--------VENDDYDKAETLQQRLEDLEQEK 387
RDC L +R+ + L KL K ++++ ++ +Y++ + + + E
Sbjct: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSEN 626
Query: 388 ISLHFQLPSRQPALSSFLGHLAAQVQAAL-------RRGATQQASGDDTHTPLRMEPRLL 440
L Q+ S + L S + HL ++ R T + ++ +R +L
Sbjct: 627 EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 441 EPTAQDSLHVSITRRDWL-LQEK-----QQLQKEIE-------ALQARMFVLEAKDQQLR 487
+ S+ V + ++ LQ+K Q+ QKEIE L ++ LE K Q L
Sbjct: 687 D---SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 488 REIEEQE---QQLQWQGCDLTPLVGQ---------------LSLGQLQEVSKALQDTLAS 529
EI +++ Q L + L L+ L+ Q + + + +
Sbjct: 744 NEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGE 803
Query: 530 AGQIPFHA--------EPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDI 581
G +P + P+ LQ R+ SL SL+ ++ S L+K+ ++
Sbjct: 804 QGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLES-------QKQMNSDLQKQCEEL 856
Query: 582 ETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGS 641
Q+ +E + H + ++ I L + + ++++ L K+L
Sbjct: 857 -VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 642 VKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLL 701
+ + + E+ QE + E+++K ++ L L K + + E L
Sbjct: 916 LNDKVETEQAEI--QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973
Query: 702 IQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCE 761
++ L+E SL+ E + E A I R S + K+ ++ L ++CE
Sbjct: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLI---LLQRCE 1030
Query: 762 DIGKKLLYLEDQLHTAIHSHDE---------DLIQSLRRELQMVKETL----QAMILQLQ 808
+ G L + A + + L ++ + EL+ +KE Q + +L
Sbjct: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 809 PAKEAGE 815
A+E +
Sbjct: 1091 FAEERNQ 1097
Score = 40.0 bits (92), Expect = 0.009
Identities = 105/474 (22%), Positives = 195/474 (41%), Gaps = 84/474 (17%)
Query: 366 ENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQAS 425
E D K T +L + +EK +L S Q + A+V+ + Q
Sbjct: 1966 ELDTMSKKTTALDQLSEKMKEKTQ---ELESHQSECLHCIQVAEAEVK---EKTELLQTL 2019
Query: 426 GDDTHTPLRMEPRL---LEPTAQDSLHVSITRRDW------LLQEKQQLQKEIEALQARM 476
D L+ + L L+ +DS +S+T+ + L +EK+ L KE E+LQAR+
Sbjct: 2020 SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARL 2079
Query: 477 FVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFH 536
E ++L VSKAL+ L G+
Sbjct: 2080 -------------SESDYEKL--------------------NVSKALEAALVEKGEFALR 2106
Query: 537 -AEPPETIRSLQERIKSLNLSLK-------EITTKVCMSEKFCSTLRKKVNDIETQLPAL 588
+ E + L+ I+ L + ++ I K+ E+ +L+ KV ++E +L
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMS 2166
Query: 589 LEAKMHAI-----SGNHFWTAKDLTEEI-RSLTSEREGLEGLLSKLLVLSSRNVKKLGSV 642
E + I S T K EE+ RSL L L S+ L+ + +K G +
Sbjct: 2167 EENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQL 2226
Query: 643 KE---DYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACR 699
E + + +E +E A E +KE + +E L+N+L + D E +
Sbjct: 2227 SELDKLLSSFKSLLEEKEQA-EIQIKEESKTAVEMLQNQLKELNEAVAALC--GDQEIMK 2283
Query: 700 LLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRK----TPLKESYILSAE 755
QSL +E+E Q L + + RL +++K++ LKES +
Sbjct: 2284 ATEQSL-------DPPIEEEHQ---LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2333
Query: 756 LGEKCEDIGKKL-LYLEDQLHTAIHS-HDEDLIQSLRRELQMVKETLQAMILQL 807
L + E++ ++L + +Q H A+ + + + +++L+ +++ + ++L+ + L +
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387
Score = 35.8 bits (81), Expect = 0.17
Identities = 86/374 (22%), Positives = 147/374 (39%), Gaps = 46/374 (12%)
Query: 469 IEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVS----KALQ 524
+++ A++ LEA + +++E E++ + +L + G L LQ++ L+
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLK 1262
Query: 525 DTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQ 584
D A + + P + + Q L SL+ K+ EK C L+ + ++ T+
Sbjct: 1263 DCEIDAEE--KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 585 LPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGL---EGLLSKLLVLSSRNVKKLGS 641
L +++ I+ + + EE+ L +E + L GLL LV + G
Sbjct: 1321 LN---DSRSECIT-----ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPG-GEFGE 1371
Query: 642 VKEDYNRLRREVEHQETAYE---TSVKENTMKYMETLKNKLCSCK----------CPLLG 688
+ + + + +YE S KE M + E L+ K S + C +
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE-LQEKFLSLQSEHKILHDQHCQMSS 1430
Query: 689 KVWE----ADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKT 744
K+ E D L+ S L+ +G L E Q+ EG P + + +
Sbjct: 1431 KMSELQTYVDSLKAENLVLSTNLRNFQGDL--VKEMQLGLEEGLVPSLSSSCVPDSSSLS 1488
Query: 745 PLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMI 804
L +S A L E+ D+ L LE + S DE SL+ E KET A
Sbjct: 1489 SLGDSSFYRALL-EQTGDM-SLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSA-- 1544
Query: 805 LQLQPAKEAGEREA 818
PAK E E+
Sbjct: 1545 ----PAKGVEELES 1554
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 53.5 bits (127), Expect = 8e-07
Identities = 88/402 (21%), Positives = 171/402 (42%), Gaps = 34/402 (8%)
Query: 338 RDCLLRNRRQMEVISLRLKLQK---LQEDAVENDDY-DKAETLQQRLEDLEQEKISLHFQ 393
RD ++ + +Q+E L + L+K +QE A EN+ ++ L+ ++DL E L +
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532
Query: 394 LPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSIT 453
L + L+ + +Q + L Q ++ + L + + E +D
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED------L 2586
Query: 454 RRDW--LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
RR + L +EKQ L KEIE+L+ + QL R++ +++ V +
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSI-------SQLTRQVTALQEEGTLGLYHAQLKVKEE 2639
Query: 512 SLGQLQEVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
+ +L + + Q +A + + E + + +++++K LK + +
Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK---ELKHLHHDAGIMRN 2696
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTA--KDLTEEIRSLTSEREGLEGLLSK 627
T ++V ++ L + + + N TA + + SL + R+ L +
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 628 LLVLSSRNVKKLGSVKED--YNRLRREVEHQETAYE-TSVKENTMKYMETLKNKLCSCKC 684
L ++K+L +KE NR R+ ETA+ S +EN++ ++E L +L S
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNR-ERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDE 2815
Query: 685 PLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLE 726
LL + LE +QS +A SL E + ++LE
Sbjct: 2816 QLLH--LSSQLEDSYNQVQS--FSKAMASLQNERDHLWNELE 2853
Score = 43.9 bits (102), Expect = 6e-04
Identities = 85/401 (21%), Positives = 167/401 (41%), Gaps = 75/401 (18%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
QEKQ+L ++ + +A E + Q+ +E+EE +++++ Q + +L+E
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR-----KFAKSKQQKILELEEE 1695
Query: 520 SKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCM-----SEKFCS-- 572
+ L+ + AG +T + E + S N S+KE +V M S+KF S
Sbjct: 1696 NDRLRAEVHPAG---------DTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM 1746
Query: 573 ----TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE-IRSLTSEREGLEGLLSK 627
+L ++V D++ Q+ + + + + ++TEE +S+ E E + L
Sbjct: 1747 SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806
Query: 628 LLVLSSRNVKKLGSVK----------EDYNRLRREVEH--QETAYETSVKENTMKYMETL 675
S +V S ++ N ++++ + A K+ ++ +TL
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866
Query: 676 KNKLCSCKCPLLG---------KVWEADLEACRLLIQSLQLQEAR-GSLSVEDERQMDDL 725
+N+ K LL K+ + ++ LL Q +Q + +R L E + DDL
Sbjct: 1867 ENE----KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 726 EGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCED-----IGKKLLYLE-DQLHTAIH 779
E++ L E L+ +G C+D I +LL E L +
Sbjct: 1923 -------------EERLMNQLAE---LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966
Query: 780 SHDEDLIQSLRRELQMVKETLQAMILQLQPA-KEAGEREAA 819
+E+ Q ++ + ++ E + + ++Q A KE G + A
Sbjct: 1967 ELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Score = 43.1 bits (100), Expect = 0.001
Identities = 84/401 (20%), Positives = 163/401 (40%), Gaps = 67/401 (16%)
Query: 347 QMEVISLRLKLQKLQE-DAVENDDYDKAETLQQRLEDLEQEK-ISLHFQLPSRQPALSSF 404
+ME+ ++ KLQ+ +E + +A+ Q E E+ + + QL ++ +S+
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 405 LGHLA-AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ 463
L+ Q + A ++ ++ + +T L E LL+ Q + + ++ +LQ K
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLH-EDELLQLVTQADVETEMQQKLRVLQRKL 261
Query: 464 Q---------------LQKEIEALQARMFVLEAKDQQLRRE---------IEEQEQQLQW 499
+ LQ+E+ A + R +L + QQ+ E E +E ++
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKE 559
+ +L +LS LQE L + AGQ AE +L+++ K+ ++E
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA--QAELESRYSALEQKHKA---EMEE 376
Query: 560 ITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSERE 619
T+ + +K L+ + ++ Q LL+ K A + I+ L + +
Sbjct: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDKNE--------QAVQSAQTIQQLEDQLQ 428
Query: 620 GLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKL 679
+K + + NRL ++ ETA +TS + Y E +
Sbjct: 429 -----------------QKSKEISQFLNRL--PLQQHETASQTSFPD---VYNEGTQAVT 466
Query: 680 CSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER 720
L +V E + E LL+ S++L+E L E+E+
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEE----LKAENEK 503
Score = 43.1 bits (100), Expect = 0.001
Identities = 81/382 (21%), Positives = 163/382 (42%), Gaps = 62/382 (16%)
Query: 458 LLQEKQQLQKEI-EALQARMFVL---EAKDQQLRREIEEQ-------EQQLQWQGCDLTP 506
L +EK+QLQK++ EAL +R +L + K++ LR E+++Q ++Q Q +
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 507 LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCM 566
+ QL Q+Q V +++ L S Q E+ S + L + ++ T+ +
Sbjct: 1229 IGDQLRQLQIQ-VRESIDGKLPSTDQ-------QESCSSTPGLEEPLFKATEQHHTQPVL 1280
Query: 567 SEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLS 626
C D A+ G + + +++ + +E+ LE +S
Sbjct: 1281 ESNLCPDWPSHSEDAS------------ALQGG--TSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 627 KLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPL 686
++ +++ ++E N+ E+E +T V + E+L+ KL S + +
Sbjct: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKT-----VSHEAEVHAESLQQKLESSQLQI 1381
Query: 687 LG----KVWEADLEACRLLIQ---------SLQLQEARGSLS---VEDERQMDDLEGAAP 730
G + + L+ + LI S QL E +L+ E Q D ++
Sbjct: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT 1441
Query: 731 PIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKK---LLYLEDQLHTAIHSHDEDLIQ 787
+ + D+R +K+ + E+ +K E+IG++ ++ +L A+ S E L +
Sbjct: 1442 QLEMQAKEHDER---IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498
Query: 788 --SLRRELQMVKETLQAMILQL 807
SL+ EL + + T++ + L
Sbjct: 1499 NKSLQEELSLARGTIERLTKSL 1520
Score = 36.6 bits (83), Expect = 0.099
Identities = 105/562 (18%), Positives = 229/562 (40%), Gaps = 67/562 (11%)
Query: 267 SLLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSW 326
+LL ++ +L++ + E + L + + L+ S+ G+ DA
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI----GNYCQDVTDAQIK 1950
Query: 327 DTLLRKWEPVLRDC----------LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETL 376
+ LL L+ C L++ + ++E + L+K+Q E + A+ L
Sbjct: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
Query: 377 QQRLEDLEQEKISLHFQLPSRQPALSSF------LGHLAAQVQAALRRGATQQASGDDTH 430
Q+ L++ +QE L Q +S+ L + + Q L A +
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 431 TPLRME----PRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQL 486
+ E LL+ T ++ V L+ K++LQ E+++++M + KD+ L
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM---KQKDEDL 2123
Query: 487 RREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSL 546
R +E+ E++ + ++ Q L L+ L++T+ Q+ + + E ++ L
Sbjct: 2124 ERRLEQAEEKHLKEKKNM-----QEKLDALRREKVHLEETIGEI-QVTLNKKDKE-VQQL 2176
Query: 547 QERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKD 606
QE + S L T + + + + E + +++K I
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED-NCSV 2235
Query: 607 LTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDY-NRLRREVEHQETAYETSVK 665
L +++R ++ E L+ N+ +L K+ + ++ + EV+ Q+ +T
Sbjct: 2236 LKDQLRQMSIHMEELK-----------INISRLEHDKQIWESKAQTEVQLQQKVCDTLQG 2284
Query: 666 EN--TMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSL-----QLQEARGSLSVED 718
EN + +E ++ S + L E++L++ + + L + +E +G+L
Sbjct: 2285 ENKELLSQLEETRHLYHSSQNEL--AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGII 2342
Query: 719 ERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAI 778
+Q D++ + S ++ +T L+ S L++ L E+ +K++ L AI
Sbjct: 2343 RQQEADIQNSK-------FSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395
Query: 779 HSHDEDLIQSLRRELQMVKETL 800
+L Q +E++ ++ L
Sbjct: 2396 QVAIAELRQQHDKEIKELENLL 2417
Score = 34.7 bits (78), Expect = 0.37
Identities = 90/507 (17%), Positives = 190/507 (37%), Gaps = 58/507 (11%)
Query: 338 RDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSR 397
+DC+ R Q ++ +L ++ L+ V+ + E ++ L + + +L S
Sbjct: 2026 KDCI---RYQEKISALERTVKALE--FVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
Query: 398 QPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
+ L A + L+ Q++ + + ++ + LE + + + +
Sbjct: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
Query: 456 -----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQ 510
D L +EK L++ I +Q + + + QQL+ ++ QL ++ L
Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 511 LS--LGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEI-------- 560
+ + ++ + D + S + E + L+++++ +++ ++E+
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKE--DNCSVLKDQLRQMSIHMEELKINISRLE 2258
Query: 561 ----------TTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE 610
T+V + +K C TL+ + ++ +Q LE H + AK L E
Sbjct: 2259 HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQ----LEETRHLYHSSQNELAK-LESE 2313
Query: 611 IRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMK 670
++SL + L L K + + D + E ET + S +E T +
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS-RELTSR 2372
Query: 671 YMETLKNKLCSCKCPLLGKVWEADLEACRLLIQ-SLQLQEARGSLSVEDERQMDDLEGAA 729
E + K L GK + L Q +++E LS E+E + E
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432
Query: 730 PPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLE-------------DQLHT 776
+ + KT KE+ A+L + K + L+ ++ H
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQL----DSFVKSMSSLQNDRDRIVGDYQQLEERHL 2488
Query: 777 AIHSHDEDLIQSLRRELQMVKETLQAM 803
+I + LIQ E +KE ++ +
Sbjct: 2489 SIILEKDQLIQEAAAENNKLKEEIRGL 2515
Score = 32.0 bits (71), Expect = 2.4
Identities = 54/272 (19%), Positives = 107/272 (39%), Gaps = 39/272 (14%)
Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLG 514
+D + Q+ QLQ++ EALQ + K ++L+ +
Sbjct: 65 KDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAK----------------------A 102
Query: 515 QLQEVSKALQDTLASAGQI-PFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCST 573
+L ++K +++ A G + P + E + + + +++I K+ E+ ST
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIST 162
Query: 574 LRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLV--L 631
L+ ++ + + PA +M F K +E S L+ LS+
Sbjct: 163 LQAQLTQAQAEQPAQSSTEM-----EEFVMMKQQLQEKEEFIST---LQAQLSQTQAEQA 214
Query: 632 SSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVW 691
+ + V++ + E RL E E + + V+ + + L+ KL + L+G+
Sbjct: 215 AQQVVREKDARFETQVRL-HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
Query: 692 EADLEACRLLIQSLQLQEARGSLSVEDERQMD 723
D LL Q L E R + + +QM+
Sbjct: 274 VVD-----LLQQELTAAEQRNQILSQQLQQME 300
Score = 30.4 bits (67), Expect = 7.1
Identities = 66/327 (20%), Positives = 120/327 (36%), Gaps = 43/327 (13%)
Query: 282 RNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCL 341
R S ++ + P P SL +++ D D LL++ + + + L
Sbjct: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR----------DRLLKELKNLQQQYL 2905
Query: 342 LRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPAL 401
N+ E+ L+ +LQ+ Q DK + Q E+L QE +S +L +
Sbjct: 2906 QINQEITELHPLKAQLQEYQ---------DKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956
Query: 402 SSFLGH---LAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEP-------TAQDSLHVS 451
SS+ H + Q A+ Q + + LR +P A S
Sbjct: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Query: 452 ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLR---REIEEQEQQLQWQGCDLTPLV 508
L+ E + L+ ++ + E + QQL ++ E++ L Q CD + +
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076
Query: 509 --GQLSLGQLQE----VSKALQDTLASAGQIPFHAEPPET-----IRSLQERIKSLNLSL 557
Q G L + K +Q+ A I P+ +S E ++ S
Sbjct: 3077 RENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF 3136
Query: 558 KEITTKVCMSEKFCSTLRKKVNDIETQ 584
E ++C + + + LRK + + Q
Sbjct: 3137 SEAQQQLCNTRQEVNELRKLLEEERDQ 3163
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/496 (19%), Positives = 196/496 (39%), Gaps = 60/496 (12%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
+ R Q E+ +L Q+ +E A D +K + LQQ L+DL + + QL S
Sbjct: 1394 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1449
Query: 402 SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
L A+ + + A + +A + T R LE + + T +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 456 ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
+ L+ K + K + L+ LE + ++++ ++EE E +LQ + L V
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 511 LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
+L GQ + +A + + E R LQ ++ L++ + ++
Sbjct: 1570 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
L + D+E Q + ++ + AI + L +++ E E ++
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 630 VLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGK 689
+ N KK S++ D +L+ ++ E A + + E E L +L S L G+
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELAS---SLSGR 1724
Query: 690 VWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES 749
D E RL + QL+E ++++ +G + R+ ++ L
Sbjct: 1725 NALQD-EKRRLEARIAQLEE-----------ELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 750 YILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQL-- 807
+K E ++L +L + +H ++ +++ + + L+A I QL
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 808 QPAKEAGEREAAASCM 823
Q +EA E++AA +
Sbjct: 1829 QVEQEAREKQAATKSL 1844
Score = 48.5 bits (114), Expect = 3e-05
Identities = 102/508 (20%), Positives = 211/508 (41%), Gaps = 89/508 (17%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
R + Q+E ++ K++KL+++ + DD + + + L++R+ DL E+EK
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 392 FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
+L ++ ++ S +++ L++ + + L R LE A D
Sbjct: 1026 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 452 ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
+ + + K QL K+ E LQA + +L EI ++ L+ + L G +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1120
Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
S LQ+ L S AE + R L E +++L L++ ++
Sbjct: 1121 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 572 S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
+ T+ KK D ET+ EA++ + H ++LTE++ + L+
Sbjct: 1170 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD--- 1223
Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK--------- 676
L N G ++ + ++EVEH++ E V+E K + +
Sbjct: 1224 KNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQ----SLQLQEARGSLSVEDERQMDDLEGAAPPI 732
+KL + + G + EA+ +A +L S QLQ+ + L E ++++ +
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--------V 1334
Query: 733 PPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRE 792
+L ++ + L++ L E+ K +++ + + L QL S + +Q
Sbjct: 1335 STKLRQLEEERNSLQDQ--LDEEMEAK-QNLERHISTLNIQL-----SDSKKKLQDFAST 1386
Query: 793 LQMVKETLQAMILQLQPAKEAGEREAAA 820
++ ++E + +++ + E +AAA
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Score = 42.4 bits (98), Expect = 0.002
Identities = 86/444 (19%), Positives = 175/444 (39%), Gaps = 75/444 (16%)
Query: 427 DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
+ H+ L E LL+ Q + + L +KQ+L++ + ++AR+ E +
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 484 QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
QQL+ E +EEQ E++ Q L + + + +L++ + D
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 993
Query: 532 QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
+ + + + L+ERI L +L E K K + ++++E +L
Sbjct: 994 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 587 ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
L+ K+ + + DL +I L + E L+ L++L + +
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSVKE--NTMKYMETLKNKLCSCKCPLLGKVWEA 693
+KK+ ++ + L+ +++ + A + K+ + + +E LK +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE--------------- 1154
Query: 694 DLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILS 753
L +L + L + E+++ L+ A R H ++ K + +
Sbjct: 1155 -------LEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVE 1206
Query: 754 AELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLR------RELQMVKETLQAMILQL 807
EL E+ E + L+ T + + DL LR +E++ K+ L+A + +L
Sbjct: 1207 -ELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 808 QPAKEAGEREAAASCMTAGVHEAQ 831
Q GER A + VH+ Q
Sbjct: 1265 QSKCSDGERARAE--LNDKVHKLQ 1286
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/496 (19%), Positives = 196/496 (39%), Gaps = 60/496 (12%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
+ R Q E+ +L Q+ +E A D +K + LQQ L+DL + + QL S
Sbjct: 1401 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1456
Query: 402 SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
L A+ + + A + +A + T R LE + + T +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 456 ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
+ L+ K + K + L+ LE + ++++ ++EE E +LQ + L V
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 511 LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
+L GQ + +A + + E R LQ ++ L++ + ++
Sbjct: 1577 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
L + D+E Q + ++ + AI + L +++ E E ++
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 630 VLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGK 689
+ N KK S++ D +L+ ++ E A + + E E L +L S L G+
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELAS---SLSGR 1731
Query: 690 VWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES 749
D E RL + QL+E ++++ +G + R+ ++ L
Sbjct: 1732 NALQD-EKRRLEARIAQLEE-----------ELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 750 YILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQL-- 807
+K E ++L +L + +H ++ +++ + + L+A I QL
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 808 QPAKEAGEREAAASCM 823
Q +EA E++AA +
Sbjct: 1836 QVEQEAREKQAATKSL 1851
Score = 48.5 bits (114), Expect = 3e-05
Identities = 102/508 (20%), Positives = 211/508 (41%), Gaps = 89/508 (17%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
R + Q+E ++ K++KL+++ + DD + + + L++R+ DL E+EK
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 392 FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
+L ++ ++ S +++ L++ + + L R LE A D
Sbjct: 1033 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 452 ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
+ + + K QL K+ E LQA + +L EI ++ L+ + L G +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1127
Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
S LQ+ L S AE + R L E +++L L++ ++
Sbjct: 1128 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 572 S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
+ T+ KK D ET+ EA++ + H ++LTE++ + L+
Sbjct: 1177 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD--- 1230
Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK--------- 676
L N G ++ + ++EVEH++ E V+E K + +
Sbjct: 1231 KNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQ----SLQLQEARGSLSVEDERQMDDLEGAAPPI 732
+KL + + G + EA+ +A +L S QLQ+ + L E ++++ +
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--------V 1341
Query: 733 PPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRE 792
+L ++ + L++ L E+ K +++ + + L QL S + +Q
Sbjct: 1342 STKLRQLEEERNSLQDQ--LDEEMEAK-QNLERHISTLNIQL-----SDSKKKLQDFAST 1393
Query: 793 LQMVKETLQAMILQLQPAKEAGEREAAA 820
++ ++E + +++ + E +AAA
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Score = 42.4 bits (98), Expect = 0.002
Identities = 86/444 (19%), Positives = 175/444 (39%), Gaps = 75/444 (16%)
Query: 427 DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
+ H+ L E LL+ Q + + L +KQ+L++ + ++AR+ E +
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 484 QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
QQL+ E +EEQ E++ Q L + + + +L++ + D
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 1000
Query: 532 QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
+ + + + L+ERI L +L E K K + ++++E +L
Sbjct: 1001 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 587 ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
L+ K+ + + DL +I L + E L+ L++L + +
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSVKE--NTMKYMETLKNKLCSCKCPLLGKVWEA 693
+KK+ ++ + L+ +++ + A + K+ + + +E LK +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE--------------- 1161
Query: 694 DLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILS 753
L +L + L + E+++ L+ A R H ++ K + +
Sbjct: 1162 -------LEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVE 1213
Query: 754 AELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLR------RELQMVKETLQAMILQL 807
EL E+ E + L+ T + + DL LR +E++ K+ L+A + +L
Sbjct: 1214 -ELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 808 QPAKEAGEREAAASCMTAGVHEAQ 831
Q GER A + VH+ Q
Sbjct: 1272 QSKCSDGERARAE--LNDKVHKLQ 1293
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/496 (19%), Positives = 196/496 (39%), Gaps = 60/496 (12%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
+ R Q E+ +L Q+ +E A D +K + LQQ L+DL + + QL S
Sbjct: 1401 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1456
Query: 402 SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
L A+ + + A + +A + T R LE + + T +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 456 ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
+ L+ K + K + L+ LE + ++++ ++EE E +LQ + L V
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 511 LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
+L GQ + +A + + E R LQ ++ L++ + ++
Sbjct: 1577 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
L + D+E Q + ++ + AI + L +++ E E ++
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 630 VLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGK 689
+ N KK S++ D +L+ ++ E A + + E E L +L S L G+
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELAS---SLSGR 1731
Query: 690 VWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES 749
D E RL + QL+E ++++ +G + R+ ++ L
Sbjct: 1732 NALQD-EKRRLEARIAQLEE-----------ELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 750 YILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQL-- 807
+K E ++L +L + +H ++ +++ + + L+A I QL
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 808 QPAKEAGEREAAASCM 823
Q +EA E++AA +
Sbjct: 1836 QVEQEAREKQAATKSL 1851
Score = 48.5 bits (114), Expect = 3e-05
Identities = 102/508 (20%), Positives = 211/508 (41%), Gaps = 89/508 (17%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
R + Q+E ++ K++KL+++ + DD + + + L++R+ DL E+EK
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 392 FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
+L ++ ++ S +++ L++ + + L R LE A D
Sbjct: 1033 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 452 ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
+ + + K QL K+ E LQA + +L EI ++ L+ + L G +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1127
Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
S LQ+ L S AE + R L E +++L L++ ++
Sbjct: 1128 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 572 S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
+ T+ KK D ET+ EA++ + H ++LTE++ + L+
Sbjct: 1177 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD--- 1230
Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK--------- 676
L N G ++ + ++EVEH++ E V+E K + +
Sbjct: 1231 KNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQ----SLQLQEARGSLSVEDERQMDDLEGAAPPI 732
+KL + + G + EA+ +A +L S QLQ+ + L E ++++ +
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--------V 1341
Query: 733 PPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRE 792
+L ++ + L++ L E+ K +++ + + L QL S + +Q
Sbjct: 1342 STKLRQLEEERNSLQDQ--LDEEMEAK-QNLERHISTLNIQL-----SDSKKKLQDFAST 1393
Query: 793 LQMVKETLQAMILQLQPAKEAGEREAAA 820
++ ++E + +++ + E +AAA
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Score = 42.4 bits (98), Expect = 0.002
Identities = 86/444 (19%), Positives = 175/444 (39%), Gaps = 75/444 (16%)
Query: 427 DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
+ H+ L E LL+ Q + + L +KQ+L++ + ++AR+ E +
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 484 QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
QQL+ E +EEQ E++ Q L + + + +L++ + D
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 1000
Query: 532 QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
+ + + + L+ERI L +L E K K + ++++E +L
Sbjct: 1001 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 587 ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
L+ K+ + + DL +I L + E L+ L++L + +
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSVKE--NTMKYMETLKNKLCSCKCPLLGKVWEA 693
+KK+ ++ + L+ +++ + A + K+ + + +E LK +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE--------------- 1161
Query: 694 DLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILS 753
L +L + L + E+++ L+ A R H ++ K + +
Sbjct: 1162 -------LEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVE 1213
Query: 754 AELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLR------RELQMVKETLQAMILQL 807
EL E+ E + L+ T + + DL LR +E++ K+ L+A + +L
Sbjct: 1214 -ELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 808 QPAKEAGEREAAASCMTAGVHEAQ 831
Q GER A + VH+ Q
Sbjct: 1272 QSKCSDGERARAE--LNDKVHKLQ 1293
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/496 (19%), Positives = 196/496 (39%), Gaps = 60/496 (12%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
+ R Q E+ +L Q+ +E A D +K + LQQ L+DL + + QL S
Sbjct: 1394 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1449
Query: 402 SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
L A+ + + A + +A + T R LE + + T +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 456 ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
+ L+ K + K + L+ LE + ++++ ++EE E +LQ + L V
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 511 LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
+L GQ + +A + + E R LQ ++ L++ + ++
Sbjct: 1570 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617
Query: 570 FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
L + D+E Q + ++ + AI + L +++ E E ++
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 630 VLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGK 689
+ N KK S++ D +L+ ++ E A + + E E L +L S L G+
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELAS---SLSGR 1724
Query: 690 VWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES 749
D E RL + QL+E ++++ +G + R+ ++ L
Sbjct: 1725 NALQD-EKRRLEARIAQLEE-----------ELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 750 YILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQL-- 807
+K E ++L +L + +H ++ +++ + + L+A I QL
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 808 QPAKEAGEREAAASCM 823
Q +EA E++AA +
Sbjct: 1829 QVEQEAREKQAATKSL 1844
Score = 48.5 bits (114), Expect = 3e-05
Identities = 102/508 (20%), Positives = 211/508 (41%), Gaps = 89/508 (17%)
Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
R + Q+E ++ K++KL+++ + DD + + + L++R+ DL E+EK
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 392 FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
+L ++ ++ S +++ L++ + + L R LE A D
Sbjct: 1026 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 452 ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
+ + + K QL K+ E LQA + +L EI ++ L+ + L G +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1120
Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
S LQ+ L S AE + R L E +++L L++ ++
Sbjct: 1121 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 572 S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
+ T+ KK D ET+ EA++ + H ++LTE++ + L+
Sbjct: 1170 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD--- 1223
Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK--------- 676
L N G ++ + ++EVEH++ E V+E K + +
Sbjct: 1224 KNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQ----SLQLQEARGSLSVEDERQMDDLEGAAPPI 732
+KL + + G + EA+ +A +L S QLQ+ + L E ++++ +
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--------V 1334
Query: 733 PPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRE 792
+L ++ + L++ L E+ K +++ + + L QL S + +Q
Sbjct: 1335 STKLRQLEEERNSLQDQ--LDEEMEAK-QNLERHISTLNIQL-----SDSKKKLQDFAST 1386
Query: 793 LQMVKETLQAMILQLQPAKEAGEREAAA 820
++ ++E + +++ + E +AAA
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Score = 42.4 bits (98), Expect = 0.002
Identities = 86/444 (19%), Positives = 175/444 (39%), Gaps = 75/444 (16%)
Query: 427 DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
+ H+ L E LL+ Q + + L +KQ+L++ + ++AR+ E +
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 484 QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
QQL+ E +EEQ E++ Q L + + + +L++ + D
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 993
Query: 532 QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
+ + + + L+ERI L +L E K K + ++++E +L
Sbjct: 994 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 587 ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
L+ K+ + + DL +I L + E L+ L++L + +
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 636 VKKLGSVKEDYNRLRREVEHQETAYETSVKE--NTMKYMETLKNKLCSCKCPLLGKVWEA 693
+KK+ ++ + L+ +++ + A + K+ + + +E LK +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE--------------- 1154
Query: 694 DLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILS 753
L +L + L + E+++ L+ A R H ++ K + +
Sbjct: 1155 -------LEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVE 1206
Query: 754 AELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLR------RELQMVKETLQAMILQL 807
EL E+ E + L+ T + + DL LR +E++ K+ L+A + +L
Sbjct: 1207 -ELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 808 QPAKEAGEREAAASCMTAGVHEAQ 831
Q GER A + VH+ Q
Sbjct: 1265 QSKCSDGERARAE--LNDKVHKLQ 1286
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 52.4 bits (124), Expect = 2e-06
Identities = 110/499 (22%), Positives = 208/499 (41%), Gaps = 75/499 (15%)
Query: 342 LRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPAL 401
+R +ME+ SLR +++ + + LQ+ L++L + L+ + + Q +
Sbjct: 188 IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESN 247
Query: 402 SSFLGHLA----AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ-----DSLHVSI 452
SS G LA + Q A R Q + E LEP + L +
Sbjct: 248 SSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAE 307
Query: 453 TRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIE-EQEQQLQWQGCDLTPLVGQL 511
+ + + Q+L E+E LQ V E + ++L+RE++ Q + L++Q +L
Sbjct: 308 EQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEEL 367
Query: 512 S--LGQLQEVSKALQDTLASAGQIPFHAEPPETIR---SLQERIKSLNLSLKEITTKVCM 566
L LQ+ QD E E ++ LQ ++ L + +
Sbjct: 368 KSRLCTLQKKYDTSQD------------EQNELLKMQLQLQTELRQLKVMKSTLVENQSE 415
Query: 567 SEKFC--STLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGL 624
E C L + ++ + LLE + + L EE++ +E + L
Sbjct: 416 KELLCRLQKLHLQHQNVTCEKEKLLERQ------------QQLQEELQCHEAELQHLRDT 463
Query: 625 LSKLLVLSSRNVK---KLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKL-- 679
++ + ++ + +L +K+ Y + E+E Q+ Y+ ++ + +E + K
Sbjct: 464 VASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASH 523
Query: 680 --------CSCKC-PLLGKVWEAD--LEACRLLIQSLQLQEARGSLSVEDERQMDDLEGA 728
C+ KC LL ++ E +A + + LQ+++ +ED+R+M + +G
Sbjct: 524 PIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCE---LLEDQRRMQEEQG- 579
Query: 729 APPIPPRLHSEDKRKT-PLKESYIL--SAELGEKCEDIGK-KLLY--LEDQLHTAIHSHD 782
+L E R T PL +S +L S EL K ED+ + +LLY ++++ I + D
Sbjct: 580 ------QLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQD 633
Query: 783 EDLIQSL--RRELQMVKET 799
L + L EL+ KE+
Sbjct: 634 CVLKEQLEIHEELRRFKES 652
Score = 37.7 bits (86), Expect = 0.044
Identities = 95/497 (19%), Positives = 198/497 (39%), Gaps = 61/497 (12%)
Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQV-QAALRRG 419
+E+ E ++ ++ E Q+ + ++ H L + L L AQV Q
Sbjct: 18 EEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE----LRAQVLQLVAELE 73
Query: 420 ATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVL 479
T++ +G L ++ L +D S + + ++ QQLQ E+ +L+ + +L
Sbjct: 74 ETRELAGQHEDDSLELQGLL-----EDERLASAQQAEVFTKQIQQLQGELRSLREEISLL 128
Query: 480 EAKDQQLRREIEEQ------EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQI 533
E + + +EIE++ E Q Q + + + + LQE +Q+ L +I
Sbjct: 129 EHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERI 188
Query: 534 ----------------PFHAEPPETI-----RSLQERIKSLNLSLKEITTKVCMSEKFCS 572
+EP ++ LQE ++ L + + ++ S
Sbjct: 189 RGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNS 248
Query: 573 TLRKKVNDIETQ-----LPALLEAKMHAISGNHFWTAKD-----------LTEEIRSLTS 616
+L ++ D+E++ L+++ +++ T++ L +++R
Sbjct: 249 SLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEE 308
Query: 617 EREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLK 676
+ G++ +L +E+ RL+RE++ + +++ E LK
Sbjct: 309 QMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELK 368
Query: 677 NKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDD-LEGAAPPIPPR 735
++LC+ L K + E LL LQLQ L V +++ E +
Sbjct: 369 SRLCT----LQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQK 424
Query: 736 LHSEDKRKTPLKESYI-LSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQ 794
LH + + T KE + +L E+ + +L +L D + + S+++D +LQ
Sbjct: 425 LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKD--TETHAQLQ 482
Query: 795 MVKETLQAMILQLQPAK 811
+K+ QA +L+ K
Sbjct: 483 EMKQLYQASKDELERQK 499
Score = 35.0 bits (79), Expect = 0.29
Identities = 72/354 (20%), Positives = 148/354 (41%), Gaps = 63/354 (17%)
Query: 468 EIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTL 527
E E L ++ E ++++ E+EE+E+Q+Q G VG LS+ + + +S L +T
Sbjct: 5 EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGS-----VGSLSVNKHRGLS--LTET- 56
Query: 528 ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPA 587
+ L+ ++ L L+E L + D +L
Sbjct: 57 --------------ELEELRAQVLQLVAELEE-----------TRELAGQHEDDSLELQG 91
Query: 588 LLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYN 647
LLE + A + A+ T++I+ L E L L ++ +L +L ++++ +
Sbjct: 92 LLEDERLASAQQ----AEVFTKQIQQLQGE---LRSLREEISLLEHEKESELKEIEQELH 144
Query: 648 RLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPL-----LGKVWEADLEACRLLI 702
+ E++ A E S E+ + +L+ LC + L + +E ++ + R +
Sbjct: 145 LAQAEIQSLRQAAEDSATEHESD-IASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEM 203
Query: 703 QSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES-YILSAEL----G 757
+ ++ E GSL + D L+ + R H ++ L+ES L+ +L
Sbjct: 204 E-MKSSEPSGSLGLSD---YSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLES 259
Query: 758 EKCEDIGKKLLYLEDQLHTAIHSHDEDL--------IQSLRRELQMVKETLQAM 803
E+ + ++ L + T+ S ++ +Q LR++L+ +E + M
Sbjct: 260 ERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGM 313
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 52.4 bits (124), Expect = 2e-06
Identities = 94/389 (24%), Positives = 155/389 (39%), Gaps = 90/389 (23%)
Query: 462 KQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSK 521
K++ QK + L AK + R+E+EE+ L + DL QLQ S+
Sbjct: 856 KEEFQKTKDEL--------AKSEAKRKELEEKMVTLLKEKNDL----------QLQVQSE 897
Query: 522 ALQDTLASAGQ-----IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRK 576
A D+LA A + I + I+ + ER + E+T K E CS L+K
Sbjct: 898 A--DSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 577 KVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNV 636
++D+E L A +E + HA ++++LT E GL+ ++KL S+
Sbjct: 956 DIDDLELTL-AKVEKEKHATE-----------NKVKNLTEEMAGLDETIAKL----SKEK 999
Query: 637 KKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLG-----KVW 691
K L + HQ+T + +E+ + + K KL L G K
Sbjct: 1000 KAL------------QETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKL 1047
Query: 692 EADLE-ACRLLIQSLQLQEARGSLSVEDERQMD--------DLEGAAPPIPPRLHSEDKR 742
DLE A R L L+L + D++Q+D ++ I E +
Sbjct: 1048 RMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQL 1107
Query: 743 KTPLKESYILSAELGEKCE--------------DIGKKLLYLEDQLHTA---------IH 779
+ +KE ELGE+ E D+ ++L + ++L A ++
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELN 1167
Query: 780 SHDEDLIQSLRRELQMVKETLQAMILQLQ 808
E Q LRR+L+ +AM+ L+
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAALR 1196
Score = 43.9 bits (102), Expect = 6e-04
Identities = 113/528 (21%), Positives = 212/528 (40%), Gaps = 76/528 (14%)
Query: 345 RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDL--------------EQEKISL 390
+++ E+ +L K++ E AVE K + LQ R+E+L E+++ L
Sbjct: 1085 KKEFEISNLISKIE--DEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 391 HFQLPSRQPALSSFLGHLAAQVQAALRRGAT-QQASGDDTHTPLRMEPRL--LEPTAQDS 447
+L L G +AQV+ +R A Q+ D L+ E + L DS
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 448 LHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKD----------QQLRREIEEQEQQL 497
+ + D L + KQ+L+KE L+ L + +++ R +E+Q +L
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262
Query: 498 QWQGCDLTPLVGQLSLGQLQ------EVSKALQDTLASAGQIPFHAE-PPETIRSLQERI 550
+ + + L+ L+ + + E S+ L + A Q+ + + I L+ ++
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE 610
+ + + + S C LR++ + + L A A S W K T+
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 611 IRSLTSEREGLEGLLSKLLVLSSRNVK----KLGSVKEDYNRLRREVE------------ 654
I+ T E E + L++ L + +V+ K S+++ RL+ EVE
Sbjct: 1383 IQR-TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA 1441
Query: 655 -----HQETAYETSVKENTMKYMET--------LKNKLCSCKCPLLGKVWEADLEACRLL 701
++ ++ + E KY ET +++ S + + V+E L+ L
Sbjct: 1442 CAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL 1501
Query: 702 -IQSLQLQEARGSLS---VEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELG 757
++ LQ+ L+ E +Q+ +LE I ++ E E S E
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELE----KIKKQVEQEKCEIQAALEEAEASLEHE 1557
Query: 758 E-KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMI 804
E K I +L ++ ++ I DE+ I L+R V ET+Q+ +
Sbjct: 1558 EGKILRIQLELNQVKSEVDRKIAEKDEE-IDQLKRNHTRVVETMQSTL 1604
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/390 (17%), Positives = 158/390 (40%), Gaps = 38/390 (9%)
Query: 458 LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
L Q Q+ ++ +EA+ A+ LE Q+L+ E+E+ ++ + L
Sbjct: 1396 LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA---------ACAALD 1446
Query: 518 EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
+ + L+ Q + E + + Q+ +SL+ L ++ S TLR++
Sbjct: 1447 KKQRNFDKVLSEWKQ--KYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRE 1504
Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
+++ ++ L E H +L + + + E+ ++ L +
Sbjct: 1505 NKNLQQEISDLTEQIAEGGKQIH-----ELEKIKKQVEQEKCEIQAALEEAEASLEHEEG 1559
Query: 638 KLGSVKEDYNRLRREVEHQETAYETSV---KENTMKYMETL----------KNKLCSCKC 684
K+ ++ + N+++ EV+ + + + K N + +ET+ +N K
Sbjct: 1560 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKK 1619
Query: 685 PLLGKVWEADLE---ACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDK 741
+ G + E +++ A RL +SL+ + E + +DD + +L ++
Sbjct: 1620 KMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVER 1679
Query: 742 RKTPLK---ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI---QSLRRELQM 795
R L+ E + E E+ I ++ L + +H+ + LI + L ++
Sbjct: 1680 RANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1739
Query: 796 VKETLQAMILQLQPAKEAGEREAAASCMTA 825
++ ++ +I + + A+E ++ + M A
Sbjct: 1740 LQSEVEEVIQESRNAEEKAKKAITDAAMMA 1769
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 51.6 bits (122), Expect = 3e-06
Identities = 92/429 (21%), Positives = 181/429 (42%), Gaps = 65/429 (15%)
Query: 429 THTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRR 488
T L ME LLE DSL ++R + + ++ +KEI AL++ + L+ + +L++
Sbjct: 763 TEKKLEMEKLLLE---NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKK 819
Query: 489 EIEEQEQQLQWQGCDLTPLVGQLS-----LGQLQEVSKALQDTLASAGQIPFHAEPPETI 543
+ E ++++ + T L +S + +EV L DTLA + +
Sbjct: 820 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR---------EL 870
Query: 544 RSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL--EAKMHAISGNHF 601
++++ + +N +I K +E L N I+ + +L EAKM ++S
Sbjct: 871 LDVKKKFEDINQEFVKIKDK---NEILKRNLENTQNQIKAEYISLAEHEAKMSSLS-QSM 926
Query: 602 WTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKE----------DYNRLRR 651
+D EI L + R+G E +++ + ++ K+L +++E + R
Sbjct: 927 RKVQDSNAEI--LANYRKGQEEIVTLHAEIKAQK-KELDTIQECIKVKYAPIVSFEECER 983
Query: 652 EVEHQETAYETSVKENTMKYM----ETLKNKLCSCKCPLLGKVWEADLEACRLLIQ-SLQ 706
+ + E + + E T KY E KNK + K + DL +LI+ S +
Sbjct: 984 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1043
Query: 707 LQEARGSLSVEDERQMDDLE---GAAPPIPPRLHSEDKRKT---------------PLKE 748
++ A + E +Q+ DL + +L E+ ++T PL++
Sbjct: 1044 MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1103
Query: 749 SYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQ 808
L L E++ ++L ++ + ++ + L + L+ K + + LQ
Sbjct: 1104 VEALKKSLNGTIENLKEELKSMQ-----RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQ 1158
Query: 809 PAKEAGERE 817
KEA E+E
Sbjct: 1159 -IKEAFEKE 1166
Score = 30.4 bits (67), Expect = 7.1
Identities = 53/266 (19%), Positives = 111/266 (41%), Gaps = 24/266 (9%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
++ +QL+ ++ +Q RM+ E K +Q++ ++ L + + + QL+++
Sbjct: 477 EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 536
Query: 520 SKALQDTLASAGQIPFHAEPPETIRSLQERIK-SLNLSLKEITTKVCMSEKFCSTLRKKV 578
+ A G++ + E I +R + L K + ++ M E +KV
Sbjct: 537 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 596
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
++E Q L +I F K SL++E + KL+ + + K
Sbjct: 597 TEMEGQAKELSAKLALSIPAEKFENMKS------SLSNE---VNEKAKKLVEMEREHEKS 647
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADL--- 695
L +++ L+RE+E+ + VK + E +K++L L K+ E L
Sbjct: 648 LSEIRQ----LKRELENVKAKLAQHVKP---EEHEQVKSRLEQKSGELGKKITELTLKNQ 700
Query: 696 ----EACRLLIQSLQLQEARGSLSVE 717
E ++ + + L+E +L++E
Sbjct: 701 TLQKEIEKVYLDNKLLKEQAHNLTIE 726
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 51.6 bits (122), Expect = 3e-06
Identities = 92/429 (21%), Positives = 181/429 (42%), Gaps = 65/429 (15%)
Query: 429 THTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRR 488
T L ME LLE DSL ++R + + ++ +KEI AL++ + L+ + +L++
Sbjct: 776 TEKKLEMEKLLLE---NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKK 832
Query: 489 EIEEQEQQLQWQGCDLTPLVGQLS-----LGQLQEVSKALQDTLASAGQIPFHAEPPETI 543
+ E ++++ + T L +S + +EV L DTLA + +
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR---------EL 883
Query: 544 RSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL--EAKMHAISGNHF 601
++++ + +N +I K +E L N I+ + +L EAKM ++S
Sbjct: 884 LDVKKKFEDINQEFVKIKDK---NEILKRNLENTQNQIKAEYISLAEHEAKMSSLS-QSM 939
Query: 602 WTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKE----------DYNRLRR 651
+D EI L + R+G E +++ + ++ K+L +++E + R
Sbjct: 940 RKVQDSNAEI--LANYRKGQEEIVTLHAEIKAQK-KELDTIQECIKVKYAPIVSFEECER 996
Query: 652 EVEHQETAYETSVKENTMKYM----ETLKNKLCSCKCPLLGKVWEADLEACRLLIQ-SLQ 706
+ + E + + E T KY E KNK + K + DL +LI+ S +
Sbjct: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1056
Query: 707 LQEARGSLSVEDERQMDDLE---GAAPPIPPRLHSEDKRKT---------------PLKE 748
++ A + E +Q+ DL + +L E+ ++T PL++
Sbjct: 1057 MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1116
Query: 749 SYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQ 808
L L E++ ++L ++ + ++ + L + L+ K + + LQ
Sbjct: 1117 VEALKKSLNGTIENLKEELKSMQ-----RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQ 1171
Query: 809 PAKEAGERE 817
KEA E+E
Sbjct: 1172 -IKEAFEKE 1179
Score = 30.4 bits (67), Expect = 7.1
Identities = 53/266 (19%), Positives = 111/266 (41%), Gaps = 24/266 (9%)
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
++ +QL+ ++ +Q RM+ E K +Q++ ++ L + + + QL+++
Sbjct: 490 EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 549
Query: 520 SKALQDTLASAGQIPFHAEPPETIRSLQERIK-SLNLSLKEITTKVCMSEKFCSTLRKKV 578
+ A G++ + E I +R + L K + ++ M E +KV
Sbjct: 550 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
Query: 579 NDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
++E Q L +I F K SL++E + KL+ + + K
Sbjct: 610 TEMEGQAKELSAKLALSIPAEKFENMKS------SLSNE---VNEKAKKLVEMEREHEKS 660
Query: 639 LGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADL--- 695
L +++ L+RE+E+ + VK + E +K++L L K+ E L
Sbjct: 661 LSEIRQ----LKRELENVKAKLAQHVKP---EEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 696 ----EACRLLIQSLQLQEARGSLSVE 717
E ++ + + L+E +L++E
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIE 739
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 50.8 bits (120), Expect = 5e-06
Identities = 103/499 (20%), Positives = 211/499 (42%), Gaps = 52/499 (10%)
Query: 334 EPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQ 393
+P+L LR+RR E+I L+ L K +V+ND + L++++E+LE+E
Sbjct: 910 KPLLEQKELRDRRA-ELILLKDSLAK--SPSVKNDPLSSVKELEEKIENLEKE------- 959
Query: 394 LPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSIT 453
++ ++ + +A + + L + + + LR E L + +D + + +
Sbjct: 960 CKEKEEKINK-IKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018
Query: 454 RRDWLLQ-EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLS 512
++ LL+ EKQ Q ++E +A F E + + L R++ Q + D L+ ++
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNF--EHRIEDLTRQLRNSTLQCETINSDNEDLLARIE 1076
Query: 513 LGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCS 572
LQ +K L+ + + + LQ+ K +KE T V E+
Sbjct: 1077 --TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQK-----IKEHATTVNELEELQV 1129
Query: 573 TLRKKVNDIETQLPAL----LEAKMHAISGNHFWTAKDLTEEI-RSLTSEREGLEGLLSK 627
L+K+ ++ + L +A+ + + L +E+ + LT++ +E L +
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Query: 628 LLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETL-KNKLCSCKCPL 686
+ + +K +++E+ L+ V+ E T +K+ +K + L +K +
Sbjct: 1190 IKI----QKQKQETLQEEITSLQSSVQQYEEK-NTKIKQLLVKTKKELADSKQAETDHLI 1244
Query: 687 LGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPL 746
L + +LEA + ++ ++Q A ++ E + + L+ +A L + +R T L
Sbjct: 1245 LQASLKGELEASQQQVEVYKIQLA--EITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTAL 1302
Query: 747 K-----------------ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSL 789
+ ESY + K + K + E + H E LI L
Sbjct: 1303 QEECRAAKAEQATVTSEFESYKVRVHNVLK-QQKNKSMSQAETEGAKQEREHLEMLIDQL 1361
Query: 790 RRELQMVKETLQAMILQLQ 808
+ +LQ + LQ + +LQ
Sbjct: 1362 KIKLQDSQNNLQINVSELQ 1380
Score = 48.1 bits (113), Expect = 3e-05
Identities = 102/490 (20%), Positives = 194/490 (39%), Gaps = 72/490 (14%)
Query: 359 KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRR 418
++ ED+ E D + + + + L + +EK +L FQ + L + L +
Sbjct: 769 EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828
Query: 419 GATQQASGDDTHTPLRMEPRLL----EPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQA 474
+ + LR E + E D L + L E Q L ++E +
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRL-ENQNLLIQVEEVSQ 887
Query: 475 RMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIP 534
E +++ + I+E E +L PL+ Q L + L+D+LA + +
Sbjct: 888 TCSKSEIHNEKEKCFIKEHE--------NLKPLLEQKELRDRRAELILLKDSLAKSPSV- 938
Query: 535 FHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMH 594
+P +++ L+E+I++L EK C +K+N I +L A+ K
Sbjct: 939 -KNDPLSSVKELEEKIENL--------------EKECKEKEEKINKI--KLVAVKAKKEL 981
Query: 595 AISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVE 654
S T K EE+ SL SE++ L + L+ + L ++ +L E E
Sbjct: 982 DSSRKETQTVK---EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 655 HQETAYETSVKENTMKYMETLKNKLCSCKC------PLLGKVWEADLEACRLLIQSLQLQ 708
+E +++ T + L+N C+ LL ++ A L +Q L++Q
Sbjct: 1039 RANN-FEHRIEDLTRQ----LRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1093
Query: 709 EARGSLSVEDERQMDDLE----------GAAPPIPPRLHSEDKR-----------KTPLK 747
A+ + E E + E + +L E K+ K +
Sbjct: 1094 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQ 1153
Query: 748 ESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQL 807
++ +++ E+ + ++L+ +Q T ++ EDL Q ++ + Q +ETLQ I L
Sbjct: 1154 QTTLMNMEIADY-----ERLMKELNQKLTNKNNKIEDLEQEIKIQKQK-QETLQEEITSL 1207
Query: 808 QPAKEAGERE 817
Q + + E +
Sbjct: 1208 QSSVQQYEEK 1217
Score = 32.3 bits (72), Expect = 1.9
Identities = 97/498 (19%), Positives = 191/498 (38%), Gaps = 55/498 (11%)
Query: 339 DCLLRNRRQMEVISLRLKLQKLQ-----EDAVENDDYDKAETLQQ-------RLEDLEQE 386
D LL + + E L LK + ++ ED+V D + L+Q +E+L+ E
Sbjct: 79 DALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG-DAHKELEQSHINYVKEIENLKNE 137
Query: 387 KISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD 446
+++ + + L L A Q L Q + +D L+ E + P ++
Sbjct: 138 LMAVRSKYSEDKANLQKQLEE-AMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE 196
Query: 447 SLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTP 506
+ + D EK++ +++ ++EA Q ++ I +++L
Sbjct: 197 QILYLQKQLDATTDEKKETVTQLQN------IIEANSQHYQKNINSLQEELL-------- 242
Query: 507 LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQER-IKSLNLSLKEITTKVC 565
QL +EV + + ASA + H + L+E +K S K I K
Sbjct: 243 ---QLKAIHQEEVKELMCQIEASAKE---HEAEINKLNELKENLVKQCEASEKNIQKKY- 295
Query: 566 MSEKFCSTLRKKVNDI--ETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEG 623
E LRK ++ + Q+ ++L + + K L + ++ L S+ L+
Sbjct: 296 --ECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD 353
Query: 624 LLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCK 683
++ + L + +K+++ R ++E + + KE +E LK++L
Sbjct: 354 EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLA-KEEQGCVIEKLKSELAGLN 412
Query: 684 CPLLGKVWEADLEACRLLIQ-SLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKR 742
V + + E L Q ++ E + + E++ L + + + +
Sbjct: 413 KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQE 472
Query: 743 KTPLKESY--------ILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQ 794
K +Y IL ELGE I ++ ++ Q + +H +L Q LR
Sbjct: 473 KQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH----ELQQKLRTAF- 527
Query: 795 MVKETLQAMILQLQPAKE 812
K+ L + +LQ E
Sbjct: 528 TEKDALLETVNRLQGENE 545
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 50.8 bits (120), Expect = 5e-06
Identities = 103/497 (20%), Positives = 207/497 (41%), Gaps = 70/497 (14%)
Query: 359 KLQEDAVENDDYDKA--ETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAAL 416
K+ ++ ++ D DK E + QR E+ EK + + + A+ S + L ++
Sbjct: 726 KVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 785
Query: 417 RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEAL---- 472
S T ++ + ++ Q ++ T+ L + ++L++++E +
Sbjct: 786 EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE-TQAGKLEAQNRKLEEQLEKISHQD 844
Query: 473 ---QARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
+ R+ LE + +++ E EEQ+ +L+ Q +L QLSL + + ALQ A+
Sbjct: 845 HSDKNRLLELETRLREVSLEHEEQKLELKRQLTEL-----QLSLQERESQLTALQAARAA 899
Query: 530 AGQIPFHA--EPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPA 587
A E ET +E I++L EI K C+ + D+E QL
Sbjct: 900 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQ 955
Query: 588 LLEAKMHAISGNHFWTAKDLTE---------EIRS---------------LTSEREGLEG 623
L E ++ +F+ +K L E ++RS LTS+++ +E
Sbjct: 956 LTEDNAE-LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014
Query: 624 LLSKLLVLSSRNVKKLGSVKEDYNRLRREVE-------HQETAYETSVKENTMKYMETLK 676
L + +L + V L ++ ++ R+ E +++ +E V+E + ++T K
Sbjct: 1015 LKTTCTMLEEQ-VMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRE-LQRMLDTEK 1072
Query: 677 NKLCSCK---------CPLLGKVWEADLEACRLLIQSLQLQEARGSLSVED-ERQMDDLE 726
L K +A++ A + ++ +L+ S + D E++ LE
Sbjct: 1073 QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 1132
Query: 727 GAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLI 786
A + +L +E + K L E A+L ++ + + L L A+ DL+
Sbjct: 1133 MNARSLQQKLETERELKQRLLEE---QAKLQQQMDLQKNHIFRLTQGLQEALDR--ADLL 1187
Query: 787 QSLRRELQMVKETLQAM 803
++ R +L+ E +Q +
Sbjct: 1188 KTERSDLEYQLENIQVL 1204
Score = 33.9 bits (76), Expect = 0.64
Identities = 57/231 (24%), Positives = 103/231 (44%), Gaps = 43/231 (18%)
Query: 625 LSKLLVLSSRNVK----KLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLC 680
+ K L++ S+ ++ K ++++ RL R V E S KE +K ET ++ L
Sbjct: 447 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVL--SQKEVELKASETQRSLLE 504
Query: 681 S------CKCPLLGK--------VWEADLEACRLLI----QSLQLQEARGSLSVEDERQM 722
+C L + V + D +A +LL QS +LQE + E + Q+
Sbjct: 505 QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ---EYQAQV 561
Query: 723 DDLEGAAPPIPPRLHSEDKR----KTPLKESYILSAELGEKCEDIGKKLLYLEDQ----- 773
+++ + L S +R ++ L+ES + + E K + KLL +DQ
Sbjct: 562 EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEV 621
Query: 774 ----LHTAIHSHDEDLIQSLRRELQ-MVKETLQA--MILQLQPAKEAGERE 817
I++ + IQ L+ +L+ VK + +A ++ ++ AKE ERE
Sbjct: 622 GEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE 672
Score = 30.4 bits (67), Expect = 7.1
Identities = 48/177 (27%), Positives = 68/177 (38%), Gaps = 32/177 (18%)
Query: 356 KLQKLQEDAVENDDYDKAETLQ--QRLEDL----EQEKISLHFQLPSRQPALSSFLGHLA 409
KL++ E D DK L+ RL ++ E++K+ L QL Q +L L
Sbjct: 832 KLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLT 891
Query: 410 A-QVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--------DSLHVSITRRDWLLQ 460
A Q A +QA + T E + TA D+L S T L +
Sbjct: 892 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEE 951
Query: 461 EKQQLQKEIEALQARMFVLE--------AKDQ---------QLRREIEEQEQQLQWQ 500
+ QL ++ L + F L A D+ LRREI E+E QL Q
Sbjct: 952 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 1008
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 50.8 bits (120), Expect = 5e-06
Identities = 111/495 (22%), Positives = 210/495 (42%), Gaps = 73/495 (14%)
Query: 329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVEND-DYDKA-ETLQQRLEDLEQE 386
L ++WE + Q V L+ LQ L+ A E + DY A L+ L+ L QE
Sbjct: 298 LQKQWE-------VTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQE 350
Query: 387 KISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD 446
+ L + L+SF G LA Q A T+ EP D
Sbjct: 351 LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQ---------------EPIPSD 395
Query: 447 SLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQG----- 501
+ QE Q+L ++++AL+ +E ++Q ++E+ ++LQ +
Sbjct: 396 A-----------AQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARAS 444
Query: 502 -----CDLTPLVGQLSLGQLQEVS---KALQDTLASAGQIPFH-AEPPETIRSLQERIKS 552
++ PL +LS G+ QE + LQ+ LA AE + QE +
Sbjct: 445 LERLVKEMAPLQEELS-GKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKEL 503
Query: 553 LNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIR 612
L ++ +T ++ E + + + V+D+E Q L++ K +H + E +
Sbjct: 504 LEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDK------DHLSQQVGMLERLA 557
Query: 613 SLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQET-AYETSVKENTMKY 671
+ G ++ LV + ++++ E+ R +E + +T E S +E +
Sbjct: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQA 617
Query: 672 METLKNKLCSCKCPLLGK--VWEADLEACRLLIQSLQLQEA--RGSL-SVEDE----RQM 722
L+ +L + ++G+ + E L+A + Q+LQ +E+ +GSL S+E E R +
Sbjct: 618 NRELEKELQN----VVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
Query: 723 DDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHD 782
D + A + R E + ++ IL ++ GE C+ + +++ + QL A H
Sbjct: 674 GD-QMEASLLAVRKAKEAMKAQMAEKEAILQSKEGE-CQQLREEVEQCQ-QLAEARHREL 730
Query: 783 EDLIQSLRRELQMVK 797
L +++ Q+++
Sbjct: 731 RALESQCQQQTQLIE 745
Score = 47.8 bits (112), Expect = 4e-05
Identities = 122/544 (22%), Positives = 220/544 (40%), Gaps = 106/544 (19%)
Query: 320 SGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQR 379
SG D L R+ + +L + + E+ LR + ++ QE+ + ++ T Q +
Sbjct: 460 SGKGQEADQLWRRLQELLAHT---SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQ 516
Query: 380 LEDLEQEKISLHFQ-LPSRQPALSSFLGHLAAQVQAALRR----GATQQASGDDTHT--- 431
+ + ++S H L ++ L HL+ QV R G +G+
Sbjct: 517 FLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVP 576
Query: 432 -----------PLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
P + L E D+ ++ + L Q ++L+KE++ + R +LE
Sbjct: 577 VNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLE 636
Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
K Q L+ + + LQ+ A+Q +LAS AE
Sbjct: 637 GKLQALQADYQA-----------------------LQQRESAIQGSLAS-----LEAEQA 668
Query: 541 ETIRSLQERIKSLNLSLKEI--TTKVCMSEKF---------CSTLRKKVNDIETQLPALL 589
+IR L +++++ L++++ K M+EK C LR++V + QL
Sbjct: 669 -SIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQ-QLAEAR 726
Query: 590 EAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGL----------LSKLLVLSSRNVKKL 639
++ A+ + T+ I LT+E+ G +G+ L+ L LS +L
Sbjct: 727 HRELRALESQ----CQQQTQLIEVLTAEK-GQQGVGPPTDNEARELAAQLALSQA---QL 778
Query: 640 GSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACR 699
+ + RL+ +V + ++ + + ++++L EA L +
Sbjct: 779 EVHQGEVQRLQAQVVDLQAKMRAALDDQ-----DKVQSQLSMA---------EAVLREHK 824
Query: 700 LLIQSLQLQ-EARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKESYILSAELGE 758
L+Q L+ Q EA V++ Q + EGA D+ + +E L EL +
Sbjct: 825 TLVQQLKEQNEALNRAHVQELLQCSEREGALQE-----ERADEAQQREEELRALQEELSQ 879
Query: 759 -KCEDIGKKLLY--LEDQLHTAIHSHDEDLIQ--SLRRELQMVKETLQAMILQLQPAKEA 813
KC +L + L++QLH A E IQ +L E + V+E L + +LQ AKEA
Sbjct: 880 AKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEA 939
Query: 814 GERE 817
RE
Sbjct: 940 ASRE 943
Score = 42.4 bits (98), Expect = 0.002
Identities = 91/403 (22%), Positives = 162/403 (40%), Gaps = 79/403 (19%)
Query: 456 DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQ----------GCDLT 505
D + E QL+ + L+ RM L+ ++Q+LR + +Q +QLQ + LT
Sbjct: 233 DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLT 292
Query: 506 PLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVC 565
LV +L + EV++A Q+ T++ LQ ++ L L E
Sbjct: 293 CLVAELQ--KQWEVTQATQN----------------TVKELQTCLQGLELGAAEKEEDYH 334
Query: 566 MS-EKFCSTLRKKVNDIETQLPALLEAKMH--------AISGNHFWTAKDLTEEIRSLTS 616
+ + S L+ ++E +L + H A++ TA D + S
Sbjct: 335 TALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPS 394
Query: 617 E-REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETL 675
+ + ++ L KL L K E+ NR ++ + ++ E +KE+ +E L
Sbjct: 395 DAAQEMQELGEKLQALERERTK-----VEEVNR-QQSAQLEQLVKELQLKEDARASLERL 448
Query: 676 KNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPR 735
++ + L GK EAD + R +LQE S +E +
Sbjct: 449 VKEMAPLQEELSGKGQEAD-QLWR------RLQELLAHTSSWEEELAE------------ 489
Query: 736 LHSEDKRKTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQM 795
L E K++ KE L ++ + ++L +LE QL + H DL + +++L
Sbjct: 490 LRREKKQQQEEKEL------LEQEVRSLTRQLQFLETQL-AQVSQHVSDL-EEQKKQLIQ 541
Query: 796 VKETLQAMILQLQ-----PAKE---AGEREAAASCMTAGVHEA 830
K+ L + L+ P E AGE+ A + + + EA
Sbjct: 542 DKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEA 584
Score = 38.9 bits (89), Expect = 0.020
Identities = 43/159 (27%), Positives = 70/159 (44%), Gaps = 31/159 (19%)
Query: 340 CLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQP 399
C L ++ +L +Q+LQ DA E ++ E L++++ L+QEK SL +L + +
Sbjct: 913 CALTVEKERVEEALACAVQELQ-DAKEAASRER-EGLERQVAGLQQEKESLQEKLKAAKA 970
Query: 400 ALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLL 459
A S G A QA R + Q+A+ + +T
Sbjct: 971 AAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTL--------------------------- 1003
Query: 460 QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ 498
K QL EI Q+R+ + + LR ++EEQ +QLQ
Sbjct: 1004 --KFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQ 1040
Score = 38.1 bits (87), Expect = 0.034
Identities = 98/494 (19%), Positives = 197/494 (39%), Gaps = 76/494 (15%)
Query: 359 KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ--VQAAL 416
K +++ + +D + + L ++L+ LE+E+ + + L + L + +A+L
Sbjct: 386 KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASL 445
Query: 417 RRGATQQA--------SGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQ--EKQQLQ 466
R + A G + R LL T+ ++ RR+ Q EK+ L+
Sbjct: 446 ERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLE 505
Query: 467 KEIEALQARMFVLEAKDQQLRR---EIEEQEQQLQWQGCDLTPLVGQLS----------- 512
+E+ +L ++ LE + Q+ + ++EEQ++QL L+ VG L
Sbjct: 506 QEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565
Query: 513 -LGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
G+ E + +L A +P E R LQE L + + E+
Sbjct: 566 VAGEKNEALVPVNSSLQEA-----WGKPEEEQRGLQE------AQLDDTKVQEGSQEE-- 612
Query: 572 STLRKKVNDIETQLP------ALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
LR+ ++E +L LLE K+ A+ ++ ++L ++G L
Sbjct: 613 -ELRQANRELEKELQNVVGRNQLLEGKLQALQADY-----------QALQQRESAIQGSL 660
Query: 626 SKLLVLSSRNVKKLGSVKED---YNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSC 682
+ L +++ LG E R +E + A + ++ ++ + L+ ++ C
Sbjct: 661 AS-LEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQC 719
Query: 683 KCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKR 742
+ ++ EA R L Q Q + ++ Q +G PP E
Sbjct: 720 Q-----QLAEARHRELRALESQCQQQTQLIEVLTAEKGQ----QGVGPPTDNEAR-ELAA 769
Query: 743 KTPLKESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQA 802
+ L ++ L GE + + +++ L+ ++ A+ D+D +QS + V +
Sbjct: 770 QLALSQAQ-LEVHQGE-VQRLQAQVVDLQAKMRAAL--DDQDKVQSQLSMAEAVLREHKT 825
Query: 803 MILQLQPAKEAGER 816
++ QL+ EA R
Sbjct: 826 LVQQLKEQNEALNR 839
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,890,607
Number of Sequences: 37866
Number of extensions: 1755882
Number of successful extensions: 10822
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 598
Number of HSP's that attempted gapping in prelim test: 8911
Number of HSP's gapped (non-prelim): 1998
length of query: 832
length of database: 18,247,518
effective HSP length: 111
effective length of query: 721
effective length of database: 14,044,392
effective search space: 10126006632
effective search space used: 10126006632
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.