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Search of human proteins with 6005810
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005810 mitogen-activated protein kinase kinase kinase
kinase 1 isoform 2 [Homo sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 1699 0.0
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 1632 0.0
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 719 0.0
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 719 0.0
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 696 0.0
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 626 e-179
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 250 4e-66
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 244 2e-64
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 244 2e-64
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 244 2e-64
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 244 2e-64
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 244 2e-64
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 244 2e-64
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 244 2e-64
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 244 2e-64
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 244 2e-64
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 243 5e-64
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 243 5e-64
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 242 9e-64
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 242 9e-64
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 242 9e-64
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 242 9e-64
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 242 9e-64
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 241 3e-63
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 239 1e-62
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 239 1e-62
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 239 1e-62
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 236 7e-62
gi|145275208 myosin IIIA [Homo sapiens] 218 2e-56
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 216 9e-56
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 1699 bits (4401), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
Sbjct: 1 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
Query: 61 KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
Sbjct: 61 KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
Query: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
Sbjct: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
Query: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
Sbjct: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
Query: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
Sbjct: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
Query: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
Sbjct: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
Query: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
Sbjct: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
Query: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
Sbjct: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
Query: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
Sbjct: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
Query: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
Sbjct: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
Query: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
Sbjct: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
Query: 781 LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL 833
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
Sbjct: 781 LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL 833
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 1632 bits (4226), Expect = 0.0
Identities = 799/799 (100%), Positives = 799/799 (100%)
Query: 1 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
Sbjct: 1 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
Query: 61 KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
Sbjct: 61 KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
Query: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
Sbjct: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
Query: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
Sbjct: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
Query: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
Sbjct: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
Query: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
Sbjct: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
Query: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
Sbjct: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
Query: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
Sbjct: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
Query: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
Sbjct: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
Query: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
Sbjct: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
Query: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
Sbjct: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
Query: 781 LLQELRDPTLTFRLLGSPR 799
LLQELRDPTLTFRLLGSPR
Sbjct: 781 LLQELRDPTLTFRLLGSPR 799
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 719 bits (1855), Expect = 0.0
Identities = 395/853 (46%), Positives = 537/853 (62%), Gaps = 56/853 (6%)
Query: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
DI R+P+ Y+L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
Query: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
K C+H NIVAY GSYL +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
FHNF+K+ LTK+PKKRP+A ++L+H V+QPGL+R L ++LLDK+ NP + +D+
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
+ E I IRST+R++ A+ + F KL + PP S
Sbjct: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
Query: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
S P L + D + T PPPLPPKP+ S P D P D
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
Query: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
+P +L R +SP GP TS S ++ ++E S P
Sbjct: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
Query: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
R+ KP + LPP + + A K+F+GCPL+I+ +W HP TKDQ+++ G E+G
Sbjct: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
I+ LN N+ EAT+E LFP + TW+Y INN LMSLS GKT LYSH+++ L E +K
Sbjct: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
Query: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
A + H P R+L RK ++TKI DTKGC CC+ +G +LCGAL++ +VLLQWY
Sbjct: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
+PM KF+L++ FPLP+PL+VF +L P E P VC+ +S G V+ F T+ +
Sbjct: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
Query: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
S W E+ ++ + VTQ+E D V+V +D VK+V +G + E+ +
Sbjct: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
Query: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP-- 808
E+V + + AFWKHG+Q + SD++ QE+ D T FRLLGS R LE T +P
Sbjct: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
Query: 809 HCNL-LLPGSSNS 820
H NL +L G NS
Sbjct: 833 HSNLYILAGHENS 845
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 719 bits (1855), Expect = 0.0
Identities = 395/853 (46%), Positives = 537/853 (62%), Gaps = 56/853 (6%)
Query: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
DI R+P+ Y+L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
Query: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
K C+H NIVAY GSYL +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
FHNF+K+ LTK+PKKRP+A ++L+H V+QPGL+R L ++LLDK+ NP + +D+
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
+ E I IRST+R++ A+ + F KL + PP S
Sbjct: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
Query: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
S P L + D + T PPPLPPKP+ S P D P D
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
Query: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
+P +L R +SP GP TS S ++ ++E S P
Sbjct: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
Query: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
R+ KP + LPP + + A K+F+GCPL+I+ +W HP TKDQ+++ G E+G
Sbjct: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
I+ LN N+ EAT+E LFP + TW+Y INN LMSLS GKT LYSH+++ L E +K
Sbjct: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
Query: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
A + H P R+L RK ++TKI DTKGC CC+ +G +LCGAL++ +VLLQWY
Sbjct: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
+PM KF+L++ FPLP+PL+VF +L P E P VC+ +S G V+ F T+ +
Sbjct: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
Query: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
S W E+ ++ + VTQ+E D V+V +D VK+V +G + E+ +
Sbjct: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
Query: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP-- 808
E+V + + AFWKHG+Q + SD++ QE+ D T FRLLGS R LE T +P
Sbjct: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
Query: 809 HCNL-LLPGSSNS 820
H NL +L G NS
Sbjct: 833 HSNLYILAGHENS 845
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 696 bits (1797), Expect = 0.0
Identities = 394/897 (43%), Positives = 536/897 (59%), Gaps = 92/897 (10%)
Query: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
D+ R+P++ ++L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP +D + +Q+EI+++
Sbjct: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
Query: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
K C+H NIVAY GSYL KLWICMEFCG GSLQDIY VTG LSELQI+YV RE LQGL
Sbjct: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
YLHS+ K+HRDIKGANIL+ D G V+LADFG+SAQI AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
KGGYN+LCD+W++GITAIELAELQPP+FD+HP+R LFLMTKS +QPP+LK+K KWS +
Sbjct: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245
Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
FH+F+K+ LTK+PKKRP+A K+L H V+Q L R L ++LLDK+ NP + D +D+
Sbjct: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQ-HLTRSLAIELLDKVNNPDHS-TYHDFDDD 303
Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRP----PANTARLQPPR 362
+PE A+P RI ST R+ ++ ++F ET P P + L
Sbjct: 304 DPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSE 363
Query: 363 DL----RSS-------------------------------SPRKQLSESSDDDYDDVDI- 386
++ RS+ R ++ DD+ DD +
Sbjct: 364 EIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESK 423
Query: 387 -PTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRC-ASGPP--PNSPRPGPP 442
T PPPLPPKPK S P M + G + RC SG P P+ P PP
Sbjct: 424 HSTLKAKIPPPLPPKPK----SIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPP 479
Query: 443 PSTSSPH-------------------------LTAHSEPSLWNPPSRELDKPPL--LPPK 475
P PH H +L +++ KP LPP
Sbjct: 480 PPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP- 538
Query: 476 KEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRND-QEATL 534
K+ C K+FNGCPL+IH ++W +P T+DQ+L+ GAEEGI+ LN N+ E ++
Sbjct: 539 TPKVHMGAC--FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSM 596
Query: 535 EMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPI---AHISPHRLL 591
E LFP R TW+Y +NN L+S+SGK LYSH++ GL + P+ AH P R+L
Sbjct: 597 EQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRIL 656
Query: 592 ARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLF 651
RK VS KI +TK C+ CCV +G +LCGAL+TS+VLL+W +PM KF+L++ + F
Sbjct: 657 PRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDF 716
Query: 652 PLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGALSCWLGEMSTEHRGP 710
P+P PL +F +L P E P VC+GVS GR V+ F TV + S W E T
Sbjct: 717 PIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNV 776
Query: 711 VQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAVEAVAMVGGQLQAFWKH 769
VTQ+E D ++V +D +K+V +G + + E+ +E++ + + AFWKH
Sbjct: 777 THVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKH 836
Query: 770 GVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISPHCN---LLLPGSSNS 820
G+Q + S+++ QE+ D T FRLLGS R LE T +P N +L G NS
Sbjct: 837 GMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENS 893
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 626 bits (1615), Expect = e-179
Identities = 359/845 (42%), Positives = 496/845 (58%), Gaps = 75/845 (8%)
Query: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
D+ +DPRD ++LLQR+G GTYG+V+KARD V+ +L A+K+VK++P DD+S+LQ+EI IL
Sbjct: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
Query: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
+ CRH N+VAY GSYL +LWICMEFCG GSLQ+IY TG L E QI+YVCRE L+GL
Sbjct: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
+LHSQ KIHRDIKGAN+L+ G+V+LADFG+S ++ A++A+R SFIGTPYWMAPEVAAV
Sbjct: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
KGGYNELCD+W+LGITAIEL ELQPPLF +HP+R L LM+KS +QPP+L++K +W+
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKG-PSIGDIED 305
FH+F+K+ LTK+PKKRP+A K+L H +Q L R L+ LLDK +P G PS D E
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLGTPSPEDCEL 304
Query: 306 EEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPP---- 361
E ++ P I S + ++ ++F R ET P L P
Sbjct: 305 ETYDM---FPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDP------LNEPWEEE 355
Query: 362 --------------RDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPP------PLPPKP 401
+ ++ + + L+ S ++ ++D P T PLP P
Sbjct: 356 WTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDP 415
Query: 402 KFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNP 461
P PG++ PPP+ P P T+ + +P
Sbjct: 416 PAEEPLSSPPGTL----------------PPPPSGPNSSPLLPTAWATMKQREDP----- 454
Query: 462 PSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
E LPP K+ C K+FNGCPLRIH+ W HP T+DQ L++GAEEG
Sbjct: 455 ---ERSSCHGLPP-TPKVHMGAC--FSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEG 508
Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGN 580
I+ LN ++ E TLE L R +W+Y +NNVL+SLSGK+ H+++H + GL E++ +
Sbjct: 509 IYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQV 568
Query: 581 PIA---HISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
P++ + R++ R+ +STKI DTKGC C V +G FL AL TS++LLQWY
Sbjct: 569 PLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWY 628
Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGV-SPGRPGKSVLFHT--VRFG 694
+P+ KFLL++ PLP+P + L G ELP VC+G P PG VLFH + G
Sbjct: 629 EPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAG 688
Query: 695 ALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVE 754
L QV QV+ D ++V + V++V +G P L PE+ +E
Sbjct: 689 LTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATL-APELTFDFPIE 747
Query: 755 AVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP--H 809
V + + AFW HG+Q +L ++++ QE+ D T FR+LG+ R LE T +P H
Sbjct: 748 TVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAH 807
Query: 810 CNLLL 814
NL +
Sbjct: 808 SNLYI 812
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 250 bits (638), Expect = 4e-66
Identities = 136/309 (44%), Positives = 201/309 (65%), Gaps = 12/309 (3%)
Query: 4 VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEI 63
+D D + P + +D+L++LG G+YG V+KA K +G +VA+K V +E D+ + KEI
Sbjct: 17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEI 74
Query: 64 LILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVL 122
I++ C ++V Y+GSY LWI ME+CGAGS+ DI ++ +L+E +I+ + + L
Sbjct: 75 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 134
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL YLH +KIHRDIK NIL+N G +LADFG++ Q+ T+A+R + IGTP+WMAPE
Sbjct: 135 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 194
Query: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
V + GYN + DIWSLGITAIE+AE +PP D+HP+R +F++ + PP ++
Sbjct: 195 VIQ---EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 249
Query: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV-SQPGLN--RGLILDLLD-KLKNPGKGP 298
WS F +F+K L KSP++R +AT++L H V S G++ R LI + +D KLK
Sbjct: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309
Query: 299 SIGDIEDEE 307
D +DEE
Sbjct: 310 REVDQDDEE 318
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 967 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1026
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1027 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1073
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1074 VEIYAWAPKPYHKFM 1088
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 975 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1034
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1035 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1081
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1082 VEIYAWAPKPYHKFM 1096
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 996 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1055
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1056 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1102
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1103 VEIYAWAPKPYHKFM 1117
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1004 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1063
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1064 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1110
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1111 VEIYAWAPKPYHKFM 1125
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1022 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1081
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1082 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1128
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1129 VEIYAWAPKPYHKFM 1143
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1030 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1089
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1090 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1136
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1137 VEIYAWAPKPYHKFM 1151
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1051 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1110
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1111 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1157
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1158 VEIYAWAPKPYHKFM 1172
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 244 bits (624), Expect = 2e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
D + E S SS L +P RR +L E +L+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 361 PRDLRSSSPRKQLSE 375
+ R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390
Score = 31.2 bits (69), Expect = 4.1
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1059 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1118
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
R I H P K + D +GC V + FL AL+ +
Sbjct: 1119 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1165
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1166 VEIYAWAPKPYHKFM 1180
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 244 bits (624), Expect = 2e-64
Identities = 129/312 (41%), Positives = 195/312 (62%), Gaps = 10/312 (3%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
DP + + L+R+G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
+ + Y+GSYL KLWI ME+ G GS D+ + G E QI+ + +E+L+GL YLHS
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
+KKIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ---QS 194
Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Y+ DIWSLGITAIELA+ +PP D+HP+RVLFL+ K+ PP L G ++ +F F
Sbjct: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN--NPPTL--VGDFTKSFKEF 250
Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPEL 310
I L K P RP+A ++L H+ + + + +L+D+ K K D E +
Sbjct: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR-WKAEGHSDDESDSEGS 309
Query: 311 PPAIPRRIRSTH 322
R +TH
Sbjct: 310 DSESTSRENNTH 321
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 243 bits (620), Expect = 5e-64
Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
DP + + L+++G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
+ Y+GSYL KLWI ME+ G GS D+ + G L E QI+ + RE+L+GL YLHS
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 137
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
+KKIHRDIK AN+L+++ GEV+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 194
Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Y+ DIWSLGITAIELA +PP ++HP++VLFL+ K+ PP L +G +S F
Sbjct: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 250
Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
++ L K P RP+A ++L H+ + + + +L+D+ K S D E+ +
Sbjct: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 309
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 243 bits (620), Expect = 5e-64
Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
DP + + L+++G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
+ Y+GSYL KLWI ME+ G GS D+ + G L E QI+ + RE+L+GL YLHS
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 149
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
+KKIHRDIK AN+L+++ GEV+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 150 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 206
Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Y+ DIWSLGITAIELA +PP ++HP++VLFL+ K+ PP L +G +S F
Sbjct: 207 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 262
Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
++ L K P RP+A ++L H+ + + + +L+D+ K S D E+ +
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 321
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 242 bits (618), Expect = 9e-64
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
Query: 356 ARLQPPRDLRSSSPR 370
L+ + L+ R
Sbjct: 367 EALKQQQQLQQQQQR 381
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 1011 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1070
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 1071 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1117
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1118 VEVYAWAPKPYHKFM 1132
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 242 bits (618), Expect = 9e-64
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
Query: 356 ARLQPPRDLRSSSPR 370
L+ + L+ R
Sbjct: 367 EALKQQQQLQQQQQR 381
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 1002 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1061
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 1062 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1108
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1109 VEVYAWAPKPYHKFM 1123
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 242 bits (618), Expect = 9e-64
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
Query: 356 ARLQPPRDLRSSSPR 370
L+ + L+ R
Sbjct: 367 EALKQQQQLQQQQQR 381
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 1031 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1090
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 1091 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1137
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1138 VEVYAWAPKPYHKFM 1152
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 242 bits (618), Expect = 9e-64
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
Query: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
Query: 356 ARLQPPRDLRSSSPR 370
L+ + L+ R
Sbjct: 367 EALKQQQQLQQQQQR 381
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 994 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1053
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 1054 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1100
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1101 VEVYAWAPKPYHKFM 1115
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 242 bits (618), Expect = 9e-64
Identities = 123/282 (43%), Positives = 188/282 (66%), Gaps = 9/282 (3%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
DP + + L R+G G++GEV+K D + ++VA+K++ +E +D++ +Q+EI +L C
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
I Y GSYL KLWI ME+ G GS D+ + G L E I+ + RE+L+GL YLHS
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHS 133
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
++KIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 190
Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Y+ DIWSLGITAIELA+ +PP D+HP+RVLFL+ K+ PP L +G+ S F F
Sbjct: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN--SPPTL--EGQHSKPFKEF 246
Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLK 292
++ L K P+ RP+A ++L H+ +++ + +L+D+ K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 241 bits (614), Expect = 3e-63
Identities = 128/305 (41%), Positives = 194/305 (63%), Gaps = 12/305 (3%)
Query: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
D + P + +D+L++LG G+YG VFKA K SG +VA+K V +E D+ + KEI I+
Sbjct: 17 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIM 74
Query: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVLQGL 125
+ C +V Y+GSY LWI ME+CGAGS+ DI ++ +L E +I+ + + L+GL
Sbjct: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
Query: 126 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAA 185
YLH +KIHRDIK NIL+N G +LADFG++ Q+ T+A+R + IGTP+WMAPEV
Sbjct: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 194
Query: 186 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSA 245
+ GYN + DIWSLGIT+IE+AE +PP D+HP+R +F++ + PP ++ WS
Sbjct: 195 ---EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 249
Query: 246 AFHNFIKVTLTKSPKKRPSATKMLSHQLVSQP---GLNRGLILDLLDKLKNPGKGPSIGD 302
F +F+K L K+P++R +AT++L H + + R LI + ++ +K +
Sbjct: 250 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAME-IKAKRHEEQQRE 308
Query: 303 IEDEE 307
+E+EE
Sbjct: 309 LEEEE 313
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 239 bits (609), Expect = 1e-62
Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)
Query: 3 VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
+VD D+ + RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ +
Sbjct: 10 LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69
Query: 62 EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
++ K H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
I+Y+ RE+L+GLA+LH IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
GTPYWMAPEV A Y+ D+WS GITAIE+AE PPL D+HP+R LFL+ ++
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248
Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
PPRLK K KWS F +FI+ L K+ +RPS ++L H + R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306
Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
K D E+EE E+P + SS + +P RR +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
E +L + LR K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389
Score = 34.7 bits (78), Expect = 0.38
Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 911 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 970
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 971 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 1017
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1018 VEVYAWAPKPYHKFM 1032
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 239 bits (609), Expect = 1e-62
Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)
Query: 3 VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
+VD D+ + RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ +
Sbjct: 10 LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69
Query: 62 EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
++ K H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
I+Y+ RE+L+GLA+LH IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
GTPYWMAPEV A Y+ D+WS GITAIE+AE PPL D+HP+R LFL+ ++
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248
Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
PPRLK K KWS F +FI+ L K+ +RPS ++L H + R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306
Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
K D E+EE E+P + SS + +P RR +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
E +L + LR K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389
Score = 34.7 bits (78), Expect = 0.38
Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 857 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 916
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 917 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 963
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 964 VEVYAWAPKPYHKFM 978
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 239 bits (609), Expect = 1e-62
Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)
Query: 3 VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
+VD D+ + RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ +
Sbjct: 10 LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69
Query: 62 EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
++ K H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
I+Y+ RE+L+GLA+LH IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
GTPYWMAPEV A Y+ D+WS GITAIE+AE PPL D+HP+R LFL+ ++
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248
Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
PPRLK K KWS F +FI+ L K+ +RPS ++L H + R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306
Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
K D E+EE E+P + SS + +P RR +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
E +L + LR K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389
Score = 34.7 bits (78), Expect = 0.38
Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 1019 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 1078
Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
N I H P K T + D +GC V + FL AL++S
Sbjct: 1079 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 1125
Query: 631 VVLLQWY-QPMNKFL 644
V + W +P +KF+
Sbjct: 1126 VEVYAWAPKPYHKFM 1140
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 236 bits (602), Expect = 7e-62
Identities = 142/370 (38%), Positives = 212/370 (57%), Gaps = 19/370 (5%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
DP + ++++ LG G +G+V+KA++K +G L A K+++ + ++++ EI IL TC H
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
Query: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
IV G+Y KLWI +EFC G++ I ++ L+E QI VCR++L+ L +LHS
Sbjct: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
++ IHRD+K N+L+ G++RLADFG+SA+ TL +R SFIGTPYWMAPEV
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
Query: 191 G--YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
Y+ DIWSLGIT IE+A+++PP +++P+RVL + KS PP L KWS F
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268
Query: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIED--- 305
+F+K+ L K+P+ RPSA ++L H VS N+ L +L K + +IED
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-----LRELVAEAKAEVMEEIEDGRD 323
Query: 306 --EEPELPPAIPRRIRSTHRSSSLGIP--DADCCRRHMEFRKLRGMETRPPANTARLQP- 360
EE + A T SS + P +AD L +++ N QP
Sbjct: 324 EGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPS 383
Query: 361 -PRDLRSSSP 369
R L+++SP
Sbjct: 384 GDRSLQTTSP 393
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 218 bits (554), Expect = 2e-56
Identities = 120/280 (42%), Positives = 175/280 (62%), Gaps = 21/280 (7%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVST-LQKEILILKTCR 70
DP D +++ + +G GTYG+VFK +K +G A+K+ ++P D+ ++ E ILK
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73
Query: 71 -HANIVAYHGSYLWLQK-----LWICMEFCGAGSLQDIYQVTGSL------SELQISYVC 118
H N+V ++G Y K LW+ +E C GS+ D+ V G L SE I+Y+
Sbjct: 74 DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYIL 131
Query: 119 REVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYW 178
E L GL +LH+ K IHRD+KG NIL+ G V+L DFG+SAQ+ +T RR + +GTP+W
Sbjct: 132 HEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191
Query: 179 MAPEVAAV--ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR 236
MAPEV A L Y+ CD WSLGITAIEL + PPL D+HP+R LF + ++ PP+
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPK 249
Query: 237 LKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ 276
L++ WSA F++FI LTK +KRP+ +++L H+ ++Q
Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 216 bits (549), Expect = 9e-56
Identities = 119/318 (37%), Positives = 190/318 (59%), Gaps = 8/318 (2%)
Query: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
+P D ++++ LG G +G+V+KA++K + L A K++ + ++++ EI IL +C H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
NIV ++ + LWI +EFC G++ + ++ L+E QI VC++ L L YLH
Sbjct: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEV--AAVAL 188
K IHRD+K NIL G+++LADFG+SA+ T+ RR SFIGTPYWMAPEV +
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
Query: 189 KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
Y+ D+WSLGIT IE+AE++PP +++P+RVL + KS +PP L + +WS+ F
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Query: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEP 308
+F+K L K+ R + +++L H V+ N+ + + + + G EDEE
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDS-NKPIRELIAEAKAEVTEEVEDGKEEDEEE 325
Query: 309 ELPPAIPRRIRSTHRSSS 326
E ++P I ++ R+SS
Sbjct: 326 ETENSLP--IPASKRASS 341
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,325,859
Number of Sequences: 37866
Number of extensions: 2303969
Number of successful extensions: 19954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 831
Number of HSP's successfully gapped in prelim test: 865
Number of HSP's that attempted gapping in prelim test: 12151
Number of HSP's gapped (non-prelim): 5370
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.