Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 55770838

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55770838 chloride channel 3 isoform b [Homo sapiens]
         (818 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55770838 chloride channel 3 isoform b [Homo sapiens]              1662   0.0  
gi|55770840 chloride channel 3 isoform e [Homo sapiens]              1627   0.0  
gi|153252026 chloride channel 4 [Homo sapiens]                       1268   0.0  
gi|189217923 chloride channel 5 isoform a [Homo sapiens]             1251   0.0  
gi|189217921 chloride channel 5 isoform a [Homo sapiens]             1251   0.0  
gi|4557473 chloride channel 5 isoform b [Homo sapiens]               1213   0.0  
gi|167466160 chloride channel 7 isoform b [Homo sapiens]              253   7e-67
gi|14149607 chloride channel 7 isoform a [Homo sapiens]               253   7e-67
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]           228   2e-59
gi|156104869 chloride channel 2 [Homo sapiens]                        216   7e-56
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]       195   2e-49
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]             179   7e-45
gi|155969705 chloride channel Kb [Homo sapiens]                       178   2e-44
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]             178   2e-44
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]          114   3e-25
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]           69   1e-11
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]           69   1e-11
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]               32   2.4  

>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
          Length = 818

 Score = 1662 bits (4304), Expect = 0.0
 Identities = 818/818 (100%), Positives = 818/818 (100%)

Query: 1   MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
           MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
Sbjct: 1   MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60

Query: 61  NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
           NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
Sbjct: 61  NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120

Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
           SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180

Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
           FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240

Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
           IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300

Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
           PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360

Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
           FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420

Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
           TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480

Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
           SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540

Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
           VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600

Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
           TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660

Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
           RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720

Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
           KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780

Query: 781 RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818
           RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
Sbjct: 781 RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818


>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
          Length = 866

 Score = 1627 bits (4213), Expect = 0.0
 Identities = 800/806 (99%), Positives = 803/806 (99%)

Query: 1   MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
           MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
Sbjct: 1   MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60

Query: 61  NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
           NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
Sbjct: 61  NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120

Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
           SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180

Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
           FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240

Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
           IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300

Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
           PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360

Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
           FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420

Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
           TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480

Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
           SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540

Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
           VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600

Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
           TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660

Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
           RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720

Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
           KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780

Query: 781 RQCLVTHNGRLLGIITKKDILRHMAQ 806
           RQCLVTHNG +LGIITKK+IL H+ Q
Sbjct: 781 RQCLVTHNGIVLGIITKKNILEHLEQ 806


>gi|153252026 chloride channel 4 [Homo sapiens]
          Length = 760

 Score = 1268 bits (3281), Expect = 0.0
 Identities = 594/760 (78%), Positives = 677/760 (89%)

Query: 59  MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEM 118
           M N G+++ S +L+D LDEP P VGTY+DFHTIDW+REK +D +RHR+I SK KES WE 
Sbjct: 1   MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60

Query: 119 TKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNE 178
            KSL DAWSGW+V+ L GL +G LAG+ID+A DWMTDLKEG+CLSA WY+HEQCCW SNE
Sbjct: 61  IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120

Query: 179 TTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACG 238
           TTFE+RDKCP W+ W+EL++ Q+EG  +YI+NY+MYI WAL FAFLAVSLV+VFAPYACG
Sbjct: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180

Query: 239 SGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSY 298
           SGIPEIKTILSGFIIRGYLGKWTL+IKT+TLVL V+SGLSLGKEGPLVHVACCCGN FS 
Sbjct: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240

Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
           LF KYS NE K+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
Sbjct: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300

Query: 359 AAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRR 418
           AAF LRSINPFGNSRLVLFYVEYHTPWY+ ELFPFILLGVFGGLWG  FIR NIAWCRRR
Sbjct: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360

Query: 419 KSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM 478
           K+T+ GKYPVLEVI+V AITA+IA+PNPYTR +TSELI ELF DCG LESS LCDY ND 
Sbjct: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420

Query: 479 NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAG 538
           N ++ VDDIPDRPAG+GVY+A+WQL LALIFKI++T+FTFG+K+PSGLFIPSMA+GAIAG
Sbjct: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480

Query: 539 RIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598
           R+VGI VEQLAY+HHDW IF+ WC  GADC+TPGLYAMVGAAACLGGVTRMTVSLVVI+F
Sbjct: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540

Query: 599 ELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVM 658
           ELTGGLEYIVPLMAA +TSKWV DAFG+EGIYEAHI LNGYPFLD K+EFTH TLA DVM
Sbjct: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600

Query: 659 RPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIES 718
           RPRR +PPL+VLTQD+MTV+D+E +I ET YNGFPV++S++S+RL+GFA RR+L +AI++
Sbjct: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660

Query: 719 ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKL 778
           AR++QEGIV +S + F +  P LPA SP PLKLR IL++SPFTVTDHTPME VVDIFRKL
Sbjct: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720

Query: 779 GLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818
           GLRQCLVT +GRLLGIITKKD+LRHMAQ ANQDP SIMFN
Sbjct: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760


>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score = 1251 bits (3238), Expect = 0.0
 Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%)

Query: 8   HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
           +RG+ + S++S  ++SSDE+L+D     MDF   +D   LD +      Y   NGG I S
Sbjct: 10  NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66

Query: 68  STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
           S  ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W +  S+ DA+S
Sbjct: 67  SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126

Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
           GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC    W+NHE CCW S   TFEERDKC
Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186

Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
           P+W +W++LII   EG  +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246

Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
           LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI  + F KY  NE
Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306

Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
           AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366

Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
           PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426

Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
           V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N  N SK   ++
Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485

Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
           PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545

Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
           LAYYH +W +F  WC  GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605

Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
           VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665

Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
            VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725

Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
            +S + F +H+P LP  +P  LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785

Query: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818
           NGRLLGIITKKD+L+H+AQ ANQDP SI+FN
Sbjct: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816


>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score = 1251 bits (3238), Expect = 0.0
 Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%)

Query: 8   HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
           +RG+ + S++S  ++SSDE+L+D     MDF   +D   LD +      Y   NGG I S
Sbjct: 10  NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66

Query: 68  STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
           S  ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W +  S+ DA+S
Sbjct: 67  SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126

Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
           GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC    W+NHE CCW S   TFEERDKC
Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186

Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
           P+W +W++LII   EG  +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246

Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
           LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI  + F KY  NE
Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306

Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
           AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366

Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
           PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426

Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
           V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N  N SK   ++
Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485

Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
           PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545

Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
           LAYYH +W +F  WC  GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605

Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
           VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665

Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
            VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725

Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
            +S + F +H+P LP  +P  LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785

Query: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818
           NGRLLGIITKKD+L+H+AQ ANQDP SI+FN
Sbjct: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816


>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
          Length = 746

 Score = 1213 bits (3138), Expect = 0.0
 Identities = 573/747 (76%), Positives = 658/747 (88%), Gaps = 1/747 (0%)

Query: 72  LDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLV 131
           +D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W +  S+ DA+SGWL+
Sbjct: 1   MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60

Query: 132 VTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWK 191
           + L GL SG+LAGLIDI+A WMTDLKEGIC    W+NHE CCW S   TFEERDKCP+W 
Sbjct: 61  MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120

Query: 192 TWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 251
           +W++LII   EG  +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTILSGF
Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180

Query: 252 IIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKR 311
           IIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI  + F KY  NEAK+R
Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240

Query: 312 EVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGN 371
           EVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSINPFGN
Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300

Query: 372 SRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEV 431
           SRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYPV+EV
Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360

Query: 432 IIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRP 491
           ++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N  N SK   ++PDRP
Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGELPDRP 419

Query: 492 AGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYY 551
           AG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQLAYY
Sbjct: 420 AGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYY 479

Query: 552 HHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLM 611
           H +W +F  WC  GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYIVPLM
Sbjct: 480 HQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM 539

Query: 612 AAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLT 671
           AA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L VLT
Sbjct: 540 AAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLT 599

Query: 672 QDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSR 731
           QD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V +S 
Sbjct: 600 QDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSI 659

Query: 732 VCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRL 791
           + F +H+P LP  +P  LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTHNGRL
Sbjct: 660 IYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRL 719

Query: 792 LGIITKKDILRHMAQTANQDPASIMFN 818
           LGIITKKD+L+H+AQ ANQDP SI+FN
Sbjct: 720 LGIITKKDVLKHIAQMANQDPDSILFN 746


>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
          Length = 781

 Score =  253 bits (645), Expect = 7e-67
 Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W++  L G+ +G +A  IDI  + +  LK  +                N   F E+    
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 145

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
                           G    + +++     +F  +   +V    P A GSGIP+IK  L
Sbjct: 146 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 189

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
           +G  I   +   TL+IK   ++L+V  GL++GKEGP++H         S          +
Sbjct: 190 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 249

Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
              +Y   + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++     WR FFA+++
Sbjct: 250 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 309

Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
           + F L         ++    +  L+ F  +      + + E+  FI +GV GG+ GA F 
Sbjct: 310 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 369

Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
             N  W    +     +    V+E ++VAA+TA +AF   Y+      L    +   L  
Sbjct: 370 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 428

Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
            C   E +S+     +     +V    D P   G Y+ +      L++   +  +T+G+ 
Sbjct: 429 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 484

Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
           V +G+FIPS+ IGA  GR+ GI++  L               + AD   PG YA++GAAA
Sbjct: 485 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 530

Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
            LGG+ RMT+SL VI+ E T  + Y  P+M  +MT+K VGD F  EG+Y+ HI+L   PF
Sbjct: 531 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 589

Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
           L  +   T H+  A +VM    + P   +  ++ + V  I +++++T  ++NGFPV+   
Sbjct: 590 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 643

Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
              +  RL G  LR  L + ++      +   G+V        F    P  P        
Sbjct: 644 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 703

Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800
             E    + L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++G++T+KD+
Sbjct: 704 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 763

Query: 801 LRH 803
            R+
Sbjct: 764 ARY 766


>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
          Length = 805

 Score =  253 bits (645), Expect = 7e-67
 Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W++  L G+ +G +A  IDI  + +  LK  +                N   F E+    
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
                           G    + +++     +F  +   +V    P A GSGIP+IK  L
Sbjct: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
           +G  I   +   TL+IK   ++L+V  GL++GKEGP++H         S          +
Sbjct: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273

Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
              +Y   + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++     WR FFA+++
Sbjct: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333

Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
           + F L         ++    +  L+ F  +      + + E+  FI +GV GG+ GA F 
Sbjct: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393

Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
             N  W    +     +    V+E ++VAA+TA +AF   Y+      L    +   L  
Sbjct: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452

Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
            C   E +S+     +     +V    D P   G Y+ +      L++   +  +T+G+ 
Sbjct: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508

Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
           V +G+FIPS+ IGA  GR+ GI++  L               + AD   PG YA++GAAA
Sbjct: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554

Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
            LGG+ RMT+SL VI+ E T  + Y  P+M  +MT+K VGD F  EG+Y+ HI+L   PF
Sbjct: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613

Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
           L  +   T H+  A +VM    + P   +  ++ + V  I +++++T  ++NGFPV+   
Sbjct: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667

Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
              +  RL G  LR  L + ++      +   G+V        F    P  P        
Sbjct: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727

Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800
             E    + L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++G++T+KD+
Sbjct: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787

Query: 801 LRH 803
            R+
Sbjct: 788 ARY 790


>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
          Length = 869

 Score =  228 bits (580), Expect = 2e-59
 Identities = 182/627 (29%), Positives = 286/627 (45%), Gaps = 131/627 (20%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W+VV   G+ +G +   +D      T LK G+                 +T+ EE   C 
Sbjct: 81  WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
           Q               G   ++ +  + + L+F FLA SL+ +  P A GSGIPE+K  L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
           +G  + G +   TL+ K + ++ +VA GL +GKEGP++H     G               
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
           + FP Y  ++  KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++     W+  F ++
Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285

Query: 358 VAAFVLR------SINPFGNSRL--VLFYVEYHTP--------WYLFELFPFILLGVFGG 401
            A F L           +G+ +L  +L + E+           W   +L  F+++GV GG
Sbjct: 286 SATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGG 345

Query: 402 LWGAFFIRANIAWCRRRKSTKFGK---YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKE 458
           L GA F   N    + R      K     VLE ++V+ +T V+ F           +   
Sbjct: 346 LLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVF-----------VASM 394

Query: 459 LFTDCGPLESSSLCDYRNDMNASKIVDDI-----------------------PDRPAGI- 494
           +  +C  + SSS     ND    ++ +D+                       P   A + 
Sbjct: 395 VLGECRQMSSSS--QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQ 452

Query: 495 -----GVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLA 549
                G +S +  L L  +   ++  +T+GI VPSGLF+PS+  GA  GR+V   ++   
Sbjct: 453 LFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSY- 510

Query: 550 YYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP 609
                         +G   I  G +A++GAAA LGGV RMT+SL VI+ E T  + Y +P
Sbjct: 511 --------------IGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLP 556

Query: 610 LMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-AADVMRPRRNDPPLA 668
           +M  +M +KW GD F + GIY+ H+ L G P L+ + E     L A+D+M P        
Sbjct: 557 IMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPN------L 609

Query: 669 VLTQDNMTVDDIENMINETSYNGFPVI 695
                +  +  + +++  T ++ FPV+
Sbjct: 610 TYVYPHTRIQSLVSILRTTVHHAFPVV 636



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 2/72 (2%)

Query: 737 HTPSLPAESPRPL-KLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQC-LVTHNGRLLGI 794
           H   L   +PR +  +   ++ SPFTV+ +T +  V ++FR +GLR   +V   G ++GI
Sbjct: 788 HDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGI 847

Query: 795 ITKKDILRHMAQ 806
           IT+ ++     Q
Sbjct: 848 ITRHNLTYEFLQ 859


>gi|156104869 chloride channel 2 [Homo sapiens]
          Length = 898

 Score =  216 bits (550), Expect = 7e-56
 Identities = 172/539 (31%), Positives = 259/539 (48%), Gaps = 52/539 (9%)

Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
           S ++ Y+ ++ + +     +    ++ AP A GSGIPE+KTIL G +++ YL   T + K
Sbjct: 129 SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAK 188

Query: 266 TITLVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGV 322
            I L  A+ SG+ LGKEGP VH+A  C  +   F  LF     NE++  E+L+AA A GV
Sbjct: 189 VIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGV 248

Query: 323 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---NPFGNSRLVLFYV 379
              F APIGGVLFS+E  S +F ++  WR FFAA  +AF+ R +   N    +   LF  
Sbjct: 249 GCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKT 308

Query: 380 EYHT--PWYLFELFPFILLGVFGGLWGAFFIRAN--IAWCRRRKST-------KFGKYPV 428
            +    P+ L EL  F ++G+  G  GA F+  N  I    R++ T       K   +P 
Sbjct: 309 RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368

Query: 429 LEVIIVAAITAVIAFPNPYTRLNTSELI-KELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
           L  ++++ +T    FP  + +    +L  KE           +L D R  +    + +  
Sbjct: 369 LVTLLISTLT----FPPGFGQFMAGQLSQKETLV--------TLFDNRTWVRQGLVEELE 416

Query: 488 PD------RPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIV 541
           P        P    V+     L + ++ K  M+     I VP G F+P   IGA  GR+V
Sbjct: 417 PPSTSQAWNPPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 473

Query: 542 GIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601
           G   E +A     WF      +     I PG YA+VGAAA  G VT  TVS  VIVFELT
Sbjct: 474 G---ESMA----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELT 525

Query: 602 GGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR 661
           G + +I+P+M AV+ +  V  +  +  +Y++ IR+   P+L       H      V    
Sbjct: 526 GQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIM 584

Query: 662 RNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
             D P   L   + T  D+   ++ T      ++ S ES  L+G ++ R   +A+  A+
Sbjct: 585 VRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLG-SIERSQVVALLGAQ 639



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 17/46 (36%), Positives = 27/46 (58%)

Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800
           +D +PF + + T +     IF  LG+    VT  GRL+GI+T K++
Sbjct: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKEL 835


>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
          Length = 988

 Score =  195 bits (495), Expect = 2e-49
 Identities = 155/534 (29%), Positives = 250/534 (46%), Gaps = 55/534 (10%)

Query: 209 MNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 268
           + +++++ + L     +     + +P A GSGIPE+KTIL G +++ YL     + K + 
Sbjct: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218

Query: 269 LVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGVSVA 325
           L   + SG+ +GKEGP VH+A  C  +   F  +F           ++L+   A GV   
Sbjct: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278

Query: 326 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRL---VLFYVEYH 382
           FG P+GGVLFS+E  S YF ++  WR FFAA  +AFV R +  +    +    LF   + 
Sbjct: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338

Query: 383 T--PWYLFELFPFILLGVFGGLWGAFFI---RANIAWCRRRK--STKFGKYPVLEVIIVA 435
              P+ L EL  F  +G+  GL GA F+   R  +   R+ K  S    K+ +L   IV 
Sbjct: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398

Query: 436 AITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIG 495
            + A   FP    +    EL+        P E+ S   + N+       D     P  +G
Sbjct: 399 FVIASFTFPPGMGQFMAGELM--------PREAISTL-FDNNTWVKHAGD-----PESLG 444

Query: 496 VYSAIW---------QLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVE 546
             SA+W          + L  + K  M++    + +P G F+P   +GA  GR+VG   E
Sbjct: 445 -QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---E 500

Query: 547 QLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEY 606
            +A    D  +F +        I PG YA++GAAA  G V+  TVS  VI FELTG + +
Sbjct: 501 IMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAH 555

Query: 607 IVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA---KEEFTHTTLAADVMRPRRN 663
           I+P+M AV+ +  V  +  +  +Y++ I++   P+L      +   +T    D+M     
Sbjct: 556 ILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRD-- 612

Query: 664 DPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIE 717
                     + T  ++  ++  T+    P++ SK+S  L+G   R +L   ++
Sbjct: 613 ----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQ 662



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 14/46 (30%), Positives = 25/46 (54%)

Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800
           +D SPF + + T +     +F  LGL    VT  G+L G++  +++
Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEEL 866


>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
          Length = 686

 Score =  179 bits (455), Expect = 7e-45
 Identities = 168/648 (25%), Positives = 283/648 (43%), Gaps = 98/648 (15%)

Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
           S+++ Y+ +  + ++    +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147

Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
            + L   LA  S L LGK GP VH++     I +YL    +T      N++K+ E+L AA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204

Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
           +A GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF+ R +  F + +    
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264

Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425
            L         P+ L E+F F+ LG   G+    ++     +    K+ ++         
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324

Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483
             Y  L  +++A+IT    +P        S L  +   D       SL D  N   A   
Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371

Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532
            +  P  P  +      W+           L   L+ K  M +    I +P+G F+P   
Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431

Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590
           +GA  GR++G A+            F E    G   + I PG YA+ GAAA  G VT  T
Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481

Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647
           +S  ++ FELTG + + +P++ AV+ +  +  +  +   Y+  I +   P+L     +  
Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540

Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707
            +H       M     +  +  L +D   ++++  ++  T    +P++ S ESQ LVG  
Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594

Query: 708 LRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSIL----DMSPFTVT 763
            R  L  A+++                       P+ +P    L+ IL       P T+T
Sbjct: 595 QRAQLVQALQA---------------------EPPSRAPGHQCLQDILARGCPTEPVTLT 633

Query: 764 --DHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809
               T +    ++F+ L L+   VT  GR +G ++  ++ + ++   N
Sbjct: 634 LFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681


>gi|155969705 chloride channel Kb [Homo sapiens]
          Length = 687

 Score =  178 bits (452), Expect = 2e-44
 Identities = 168/643 (26%), Positives = 280/643 (43%), Gaps = 87/643 (13%)

Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
           S+++ Y+ +  + ++    +    +   P + GSGIPE+KT+L+G ++  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAK 147

Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
            + L   LA  S L LGK GP VH++       +YL    +T      N++K+ E+L AA
Sbjct: 148 VVGLSCTLACGSTLFLGKVGPFVHLSVMMA---AYLGRVRTTTIGEPENKSKQNEMLVAA 204

Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
           +A GV+  F AP  GVLFS+E +S +F +   WR FFAA   AF+ R +  F + +    
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETIT 264

Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAF----------FIRANIAWCRRRKSTK 422
            L         P+ L E+F F+ LG   G+ G+           FIR N  +  +  +T 
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNN-RFSSKLLATS 323

Query: 423 FGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASK 482
              Y  L  +++A+IT    +P    R   S L  +   D       SL D  N   A  
Sbjct: 324 KPVYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-------SLFD--NHSWALM 370

Query: 483 IVDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSM 531
             +  P  P  +      W+           L   L+ K  M +    I +P+G F+P  
Sbjct: 371 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF 430

Query: 532 AIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRM 589
             GA  GR+ G  +          FIF E    G   + I PG YA+ GAAA  G VT  
Sbjct: 431 VYGAAIGRLFGETLS---------FIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH- 480

Query: 590 TVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKE 646
           T+S  ++ FE+TG + + +P++ AV+ +  +  +  +   Y+  + +   P+L     + 
Sbjct: 481 TISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRN 539

Query: 647 EFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGF 706
             +H       M     +  +  L +D M ++++  ++  T    +P++ S ESQ LVG 
Sbjct: 540 IGSHRVRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGI 593

Query: 707 ALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766
             R  L   +++ + +        + C      +     P  LKL           +  T
Sbjct: 594 VRRAQL---VQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKL-----------SPET 639

Query: 767 PMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809
            +    ++F  L L    VT  GR +G ++  ++ + ++   N
Sbjct: 640 SLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTN 682


>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
          Length = 687

 Score =  178 bits (452), Expect = 2e-44
 Identities = 165/643 (25%), Positives = 281/643 (43%), Gaps = 87/643 (13%)

Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
           S+++ Y+ +  + ++    +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147

Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
            + L   LA  S L LGK GP VH++     I +YL    +T      N++K+ E+L AA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204

Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
           +A GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF+ R +  F + +    
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264

Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425
            L         P+ L E+F F+ LG   G+    ++     +    K+ ++         
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324

Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483
             Y  L  +++A+IT    +P        S L  +   D       SL D  N   A   
Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371

Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532
            +  P  P  +      W+           L   L+ K  M +    I +P+G F+P   
Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431

Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590
           +GA  GR++G A+            F E    G   + I PG YA+ GAAA  G VT  T
Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481

Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647
           +S  ++ FELTG + + +P++ AV+ +  +  +  +   Y+  I +   P+L     +  
Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540

Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707
            +H       M     +  +  L +D   ++++  ++  T    +P++ S ESQ LVG  
Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594

Query: 708 LRRDLTIAIES-ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766
            R  L  A+++    +  G     +   A+  P+ P                  T+   T
Sbjct: 595 QRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPV---------------TLTLFSET 639

Query: 767 PMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809
            +    ++F+ L L+   VT  GR +G ++  ++ + ++   N
Sbjct: 640 TLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682


>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
          Length = 353

 Score =  114 bits (286), Expect = 3e-25
 Identities = 80/246 (32%), Positives = 120/246 (48%), Gaps = 46/246 (18%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W+VV   G+ +G +   +D      T LK G+                 +T+ EE   C 
Sbjct: 81  WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
           Q               G   ++ +  + + L+F FLA SL+ +  P A GSGIPE+K  L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
           +G  + G +   TL+ K + ++ +VA GL +GKEGP++H     G               
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
           + FP Y  ++  KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++     W+  F ++
Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285

Query: 358 VAAFVL 363
            A F L
Sbjct: 286 SATFTL 291


>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
          Length = 308

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W+VV   G+ +G +   +D      T LK G+                 +T+ EE   C 
Sbjct: 81  WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
           Q               G   ++ +  + + L+F FLA SL+ +  P A GSGIPE+K  L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308
           +G  + G +   TL+ K + ++ +VA GL +GKEGP++H     G++     P++ +   
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222

Query: 309 KK 310
           +K
Sbjct: 223 RK 224


>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
          Length = 320

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%)

Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
           W+VV   G+ +G +   +D      T LK G+                 +T+ EE   C 
Sbjct: 81  WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121

Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
           Q               G   ++ +  + + L+F FLA SL+ +  P A GSGIPE+K  L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166

Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308
           +G  + G +   TL+ K + ++ +VA GL +GKEGP++H     G++     P++ +   
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222

Query: 309 KK 310
           +K
Sbjct: 223 RK 224


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score = 32.0 bits (71), Expect = 2.4
 Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 22/119 (18%)

Query: 511 IIMTVFTF-GIKVPSGLFIPSMAIGAIAGRIV----GIAVEQLAYYHHDWFIFKEWCEVG 565
           +I+ VFT   +K P  LF+ S+A   I    +     +A E + Y    W+  K WCE+ 
Sbjct: 69  VIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY----WYFGKAWCEI- 123

Query: 566 ADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP----LMAAVMTSKWV 620
                   Y  +    C   +  +    +   + +T  +EY +      + A++ + WV
Sbjct: 124 --------YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWV 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,155,038
Number of Sequences: 37866
Number of extensions: 1293082
Number of successful extensions: 2789
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 2712
Number of HSP's gapped (non-prelim): 26
length of query: 818
length of database: 18,247,518
effective HSP length: 111
effective length of query: 707
effective length of database: 14,044,392
effective search space: 9929385144
effective search space used: 9929385144
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press