BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|55770838 chloride channel 3 isoform b [Homo sapiens] (818 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|55770838 chloride channel 3 isoform b [Homo sapiens] 1662 0.0 gi|55770840 chloride channel 3 isoform e [Homo sapiens] 1627 0.0 gi|153252026 chloride channel 4 [Homo sapiens] 1268 0.0 gi|189217923 chloride channel 5 isoform a [Homo sapiens] 1251 0.0 gi|189217921 chloride channel 5 isoform a [Homo sapiens] 1251 0.0 gi|4557473 chloride channel 5 isoform b [Homo sapiens] 1213 0.0 gi|167466160 chloride channel 7 isoform b [Homo sapiens] 253 7e-67 gi|14149607 chloride channel 7 isoform a [Homo sapiens] 253 7e-67 gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 228 2e-59 gi|156104869 chloride channel 2 [Homo sapiens] 216 7e-56 gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 195 2e-49 gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 179 7e-45 gi|155969705 chloride channel Kb [Homo sapiens] 178 2e-44 gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 178 2e-44 gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 114 3e-25 gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 69 1e-11 gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 69 1e-11 gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 32 2.4 >gi|55770838 chloride channel 3 isoform b [Homo sapiens] Length = 818 Score = 1662 bits (4304), Expect = 0.0 Identities = 818/818 (100%), Positives = 818/818 (100%) Query: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT Sbjct: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60 Query: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK Sbjct: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120 Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180 Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240 Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300 Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360 Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420 Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480 Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540 Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600 Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660 Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720 Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780 Query: 781 RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818 RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN Sbjct: 781 RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818 >gi|55770840 chloride channel 3 isoform e [Homo sapiens] Length = 866 Score = 1627 bits (4213), Expect = 0.0 Identities = 800/806 (99%), Positives = 803/806 (99%) Query: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT Sbjct: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60 Query: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK Sbjct: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120 Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180 Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240 Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300 Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360 Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420 Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480 Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540 Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600 Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660 Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720 Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780 Query: 781 RQCLVTHNGRLLGIITKKDILRHMAQ 806 RQCLVTHNG +LGIITKK+IL H+ Q Sbjct: 781 RQCLVTHNGIVLGIITKKNILEHLEQ 806 >gi|153252026 chloride channel 4 [Homo sapiens] Length = 760 Score = 1268 bits (3281), Expect = 0.0 Identities = 594/760 (78%), Positives = 677/760 (89%) Query: 59 MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEM 118 M N G+++ S +L+D LDEP P VGTY+DFHTIDW+REK +D +RHR+I SK KES WE Sbjct: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60 Query: 119 TKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNE 178 KSL DAWSGW+V+ L GL +G LAG+ID+A DWMTDLKEG+CLSA WY+HEQCCW SNE Sbjct: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120 Query: 179 TTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACG 238 TTFE+RDKCP W+ W+EL++ Q+EG +YI+NY+MYI WAL FAFLAVSLV+VFAPYACG Sbjct: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180 Query: 239 SGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSY 298 SGIPEIKTILSGFIIRGYLGKWTL+IKT+TLVL V+SGLSLGKEGPLVHVACCCGN FS Sbjct: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240 Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358 LF KYS NE K+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV Sbjct: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300 Query: 359 AAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRR 418 AAF LRSINPFGNSRLVLFYVEYHTPWY+ ELFPFILLGVFGGLWG FIR NIAWCRRR Sbjct: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360 Query: 419 KSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM 478 K+T+ GKYPVLEVI+V AITA+IA+PNPYTR +TSELI ELF DCG LESS LCDY ND Sbjct: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420 Query: 479 NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAG 538 N ++ VDDIPDRPAG+GVY+A+WQL LALIFKI++T+FTFG+K+PSGLFIPSMA+GAIAG Sbjct: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480 Query: 539 RIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598 R+VGI VEQLAY+HHDW IF+ WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVI+F Sbjct: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540 Query: 599 ELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVM 658 ELTGGLEYIVPLMAA +TSKWV DAFG+EGIYEAHI LNGYPFLD K+EFTH TLA DVM Sbjct: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600 Query: 659 RPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIES 718 RPRR +PPL+VLTQD+MTV+D+E +I ET YNGFPV++S++S+RL+GFA RR+L +AI++ Sbjct: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660 Query: 719 ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKL 778 AR++QEGIV +S + F + P LPA SP PLKLR IL++SPFTVTDHTPME VVDIFRKL Sbjct: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720 Query: 779 GLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818 GLRQCLVT +GRLLGIITKKD+LRHMAQ ANQDP SIMFN Sbjct: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760 >gi|189217923 chloride channel 5 isoform a [Homo sapiens] Length = 816 Score = 1251 bits (3238), Expect = 0.0 Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%) Query: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67 +RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S Sbjct: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66 Query: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127 S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S Sbjct: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126 Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187 GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186 Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247 P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246 Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307 LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306 Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367 AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366 Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427 PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426 Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487 V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++ Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485 Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547 PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545 Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607 LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605 Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667 VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665 Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727 VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725 Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787 +S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785 Query: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818 NGRLLGIITKKD+L+H+AQ ANQDP SI+FN Sbjct: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816 >gi|189217921 chloride channel 5 isoform a [Homo sapiens] Length = 816 Score = 1251 bits (3238), Expect = 0.0 Identities = 596/811 (73%), Positives = 693/811 (85%), Gaps = 4/811 (0%) Query: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67 +RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S Sbjct: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66 Query: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127 S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S Sbjct: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126 Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187 GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186 Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247 P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246 Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307 LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306 Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367 AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366 Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427 PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426 Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487 V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++ Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485 Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547 PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545 Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607 LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605 Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667 VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665 Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727 VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725 Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787 +S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785 Query: 788 NGRLLGIITKKDILRHMAQTANQDPASIMFN 818 NGRLLGIITKKD+L+H+AQ ANQDP SI+FN Sbjct: 786 NGRLLGIITKKDVLKHIAQMANQDPDSILFN 816 >gi|4557473 chloride channel 5 isoform b [Homo sapiens] Length = 746 Score = 1213 bits (3138), Expect = 0.0 Identities = 573/747 (76%), Positives = 658/747 (88%), Gaps = 1/747 (0%) Query: 72 LDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLV 131 +D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+SGWL+ Sbjct: 1 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60 Query: 132 VTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWK 191 + L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKCP+W Sbjct: 61 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120 Query: 192 TWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 251 +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTILSGF Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180 Query: 252 IIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKR 311 IIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NEAK+R Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240 Query: 312 EVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGN 371 EVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSINPFGN Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300 Query: 372 SRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEV 431 SRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYPV+EV Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360 Query: 432 IIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRP 491 ++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++PDRP Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGELPDRP 419 Query: 492 AGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYY 551 AG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQLAYY Sbjct: 420 AGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYY 479 Query: 552 HHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLM 611 H +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYIVPLM Sbjct: 480 HQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM 539 Query: 612 AAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLT 671 AA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L VLT Sbjct: 540 AAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLT 599 Query: 672 QDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSR 731 QD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V +S Sbjct: 600 QDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSI 659 Query: 732 VCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRL 791 + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTHNGRL Sbjct: 660 IYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRL 719 Query: 792 LGIITKKDILRHMAQTANQDPASIMFN 818 LGIITKKD+L+H+AQ ANQDP SI+FN Sbjct: 720 LGIITKKDVLKHIAQMANQDPDSILFN 746 >gi|167466160 chloride channel 7 isoform b [Homo sapiens] Length = 781 Score = 253 bits (645), Expect = 7e-67 Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W++ L G+ +G +A IDI + + LK + N F E+ Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 145 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 G + +++ +F + +V P A GSGIP+IK L Sbjct: 146 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 189 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298 +G I + TL+IK ++L+V GL++GKEGP++H S + Sbjct: 190 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 249 Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358 +Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++ Sbjct: 250 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 309 Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408 + F L ++ + L+ F + + + E+ FI +GV GG+ GA F Sbjct: 310 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 369 Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461 N W + + V+E ++VAA+TA +AF Y+ L + L Sbjct: 370 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 428 Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521 C E +S+ + +V D P G Y+ + L++ + +T+G+ Sbjct: 429 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 484 Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581 V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA Sbjct: 485 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 530 Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641 LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF Sbjct: 531 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 589 Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696 L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+ Sbjct: 590 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 643 Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743 + RL G LR L + ++ + G+V F P P Sbjct: 644 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 703 Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800 E + L ++ SP+TV + V +FR LGLR +V N +++G++T+KD+ Sbjct: 704 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 763 Query: 801 LRH 803 R+ Sbjct: 764 ARY 766 >gi|14149607 chloride channel 7 isoform a [Homo sapiens] Length = 805 Score = 253 bits (645), Expect = 7e-67 Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W++ L G+ +G +A IDI + + LK + N F E+ Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 G + +++ +F + +V P A GSGIP+IK L Sbjct: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298 +G I + TL+IK ++L+V GL++GKEGP++H S + Sbjct: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273 Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358 +Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++ Sbjct: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333 Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408 + F L ++ + L+ F + + + E+ FI +GV GG+ GA F Sbjct: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393 Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461 N W + + V+E ++VAA+TA +AF Y+ L + L Sbjct: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452 Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521 C E +S+ + +V D P G Y+ + L++ + +T+G+ Sbjct: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508 Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581 V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA Sbjct: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554 Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641 LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF Sbjct: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613 Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696 L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+ Sbjct: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667 Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743 + RL G LR L + ++ + G+V F P P Sbjct: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727 Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800 E + L ++ SP+TV + V +FR LGLR +V N +++G++T+KD+ Sbjct: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787 Query: 801 LRH 803 R+ Sbjct: 788 ARY 790 >gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] Length = 869 Score = 228 bits (580), Expect = 2e-59 Identities = 182/627 (29%), Positives = 286/627 (45%), Gaps = 131/627 (20%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W+VV G+ +G + +D T LK G+ +T+ EE C Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297 +G + G + TL+ K + ++ +VA GL +GKEGP++H G Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226 Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357 + FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++ Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285 Query: 358 VAAFVLR------SINPFGNSRL--VLFYVEYHTP--------WYLFELFPFILLGVFGG 401 A F L +G+ +L +L + E+ W +L F+++GV GG Sbjct: 286 SATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGG 345 Query: 402 LWGAFFIRANIAWCRRRKSTKFGK---YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKE 458 L GA F N + R K VLE ++V+ +T V+ F + Sbjct: 346 LLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVF-----------VASM 394 Query: 459 LFTDCGPLESSSLCDYRNDMNASKIVDDI-----------------------PDRPAGI- 494 + +C + SSS ND ++ +D+ P A + Sbjct: 395 VLGECRQMSSSS--QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQ 452 Query: 495 -----GVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLA 549 G +S + L L + ++ +T+GI VPSGLF+PS+ GA GR+V ++ Sbjct: 453 LFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSY- 510 Query: 550 YYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP 609 +G I G +A++GAAA LGGV RMT+SL VI+ E T + Y +P Sbjct: 511 --------------IGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLP 556 Query: 610 LMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-AADVMRPRRNDPPLA 668 +M +M +KW GD F + GIY+ H+ L G P L+ + E L A+D+M P Sbjct: 557 IMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPN------L 609 Query: 669 VLTQDNMTVDDIENMINETSYNGFPVI 695 + + + +++ T ++ FPV+ Sbjct: 610 TYVYPHTRIQSLVSILRTTVHHAFPVV 636 Score = 36.6 bits (83), Expect = 0.097 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 2/72 (2%) Query: 737 HTPSLPAESPRPL-KLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQC-LVTHNGRLLGI 794 H L +PR + + ++ SPFTV+ +T + V ++FR +GLR +V G ++GI Sbjct: 788 HDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGI 847 Query: 795 ITKKDILRHMAQ 806 IT+ ++ Q Sbjct: 848 ITRHNLTYEFLQ 859 >gi|156104869 chloride channel 2 [Homo sapiens] Length = 898 Score = 216 bits (550), Expect = 7e-56 Identities = 172/539 (31%), Positives = 259/539 (48%), Gaps = 52/539 (9%) Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265 S ++ Y+ ++ + + + ++ AP A GSGIPE+KTIL G +++ YL T + K Sbjct: 129 SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAK 188 Query: 266 TITLVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGV 322 I L A+ SG+ LGKEGP VH+A C + F LF NE++ E+L+AA A GV Sbjct: 189 VIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGV 248 Query: 323 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---NPFGNSRLVLFYV 379 F APIGGVLFS+E S +F ++ WR FFAA +AF+ R + N + LF Sbjct: 249 GCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKT 308 Query: 380 EYHT--PWYLFELFPFILLGVFGGLWGAFFIRAN--IAWCRRRKST-------KFGKYPV 428 + P+ L EL F ++G+ G GA F+ N I R++ T K +P Sbjct: 309 RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368 Query: 429 LEVIIVAAITAVIAFPNPYTRLNTSELI-KELFTDCGPLESSSLCDYRNDMNASKIVDDI 487 L ++++ +T FP + + +L KE +L D R + + + Sbjct: 369 LVTLLISTLT----FPPGFGQFMAGQLSQKETLV--------TLFDNRTWVRQGLVEELE 416 Query: 488 PD------RPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIV 541 P P V+ L + ++ K M+ I VP G F+P IGA GR+V Sbjct: 417 PPSTSQAWNPPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 473 Query: 542 GIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601 G E +A WF + I PG YA+VGAAA G VT TVS VIVFELT Sbjct: 474 G---ESMA----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELT 525 Query: 602 GGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR 661 G + +I+P+M AV+ + V + + +Y++ IR+ P+L H V Sbjct: 526 GQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIM 584 Query: 662 RNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720 D P L + T D+ ++ T ++ S ES L+G ++ R +A+ A+ Sbjct: 585 VRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLG-SIERSQVVALLGAQ 639 Score = 36.6 bits (83), Expect = 0.097 Identities = 17/46 (36%), Positives = 27/46 (58%) Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800 +D +PF + + T + IF LG+ VT GRL+GI+T K++ Sbjct: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKEL 835 >gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] Length = 988 Score = 195 bits (495), Expect = 2e-49 Identities = 155/534 (29%), Positives = 250/534 (46%), Gaps = 55/534 (10%) Query: 209 MNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 268 + +++++ + L + + +P A GSGIPE+KTIL G +++ YL + K + Sbjct: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218 Query: 269 LVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGVSVA 325 L + SG+ +GKEGP VH+A C + F +F ++L+ A GV Sbjct: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278 Query: 326 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRL---VLFYVEYH 382 FG P+GGVLFS+E S YF ++ WR FFAA +AFV R + + + LF + Sbjct: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338 Query: 383 T--PWYLFELFPFILLGVFGGLWGAFFI---RANIAWCRRRK--STKFGKYPVLEVIIVA 435 P+ L EL F +G+ GL GA F+ R + R+ K S K+ +L IV Sbjct: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398 Query: 436 AITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIG 495 + A FP + EL+ P E+ S + N+ D P +G Sbjct: 399 FVIASFTFPPGMGQFMAGELM--------PREAISTL-FDNNTWVKHAGD-----PESLG 444 Query: 496 VYSAIW---------QLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVE 546 SA+W + L + K M++ + +P G F+P +GA GR+VG E Sbjct: 445 -QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---E 500 Query: 547 QLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEY 606 +A D +F + I PG YA++GAAA G V+ TVS VI FELTG + + Sbjct: 501 IMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAH 555 Query: 607 IVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA---KEEFTHTTLAADVMRPRRN 663 I+P+M AV+ + V + + +Y++ I++ P+L + +T D+M Sbjct: 556 ILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRD-- 612 Query: 664 DPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIE 717 + T ++ ++ T+ P++ SK+S L+G R +L ++ Sbjct: 613 ----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQ 662 Score = 32.3 bits (72), Expect = 1.8 Identities = 14/46 (30%), Positives = 25/46 (54%) Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800 +D SPF + + T + +F LGL VT G+L G++ +++ Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEEL 866 >gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] Length = 686 Score = 179 bits (455), Expect = 7e-45 Identities = 168/648 (25%), Positives = 283/648 (43%), Gaps = 98/648 (15%) Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265 S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G I+ YL K Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147 Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317 + L LA S L LGK GP VH++ I +YL +T N++K+ E+L AA Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204 Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373 +A GV+ F AP GVLFS+E +S +F ++ WR FFAA AF+ R + F + + Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264 Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425 L P+ L E+F F+ LG G+ ++ + K+ ++ Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324 Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483 Y L +++A+IT +P S L + D SL D N A Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371 Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532 + P P + W+ L L+ K M + I +P+G F+P Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431 Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590 +GA GR++G A+ F E G + I PG YA+ GAAA G VT T Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481 Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647 +S ++ FELTG + + +P++ AV+ + + + + Y+ I + P+L + Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540 Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707 +H M + + L +D ++++ ++ T +P++ S ESQ LVG Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594 Query: 708 LRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSIL----DMSPFTVT 763 R L A+++ P+ +P L+ IL P T+T Sbjct: 595 QRAQLVQALQA---------------------EPPSRAPGHQCLQDILARGCPTEPVTLT 633 Query: 764 --DHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809 T + ++F+ L L+ VT GR +G ++ ++ + ++ N Sbjct: 634 LFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681 >gi|155969705 chloride channel Kb [Homo sapiens] Length = 687 Score = 178 bits (452), Expect = 2e-44 Identities = 168/643 (26%), Positives = 280/643 (43%), Gaps = 87/643 (13%) Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265 S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G ++ YL K Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAK 147 Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317 + L LA S L LGK GP VH++ +YL +T N++K+ E+L AA Sbjct: 148 VVGLSCTLACGSTLFLGKVGPFVHLSVMMA---AYLGRVRTTTIGEPENKSKQNEMLVAA 204 Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373 +A GV+ F AP GVLFS+E +S +F + WR FFAA AF+ R + F + + Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETIT 264 Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAF----------FIRANIAWCRRRKSTK 422 L P+ L E+F F+ LG G+ G+ FIR N + + +T Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNN-RFSSKLLATS 323 Query: 423 FGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASK 482 Y L +++A+IT +P R S L + D SL D N A Sbjct: 324 KPVYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-------SLFD--NHSWALM 370 Query: 483 IVDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSM 531 + P P + W+ L L+ K M + I +P+G F+P Sbjct: 371 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF 430 Query: 532 AIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRM 589 GA GR+ G + FIF E G + I PG YA+ GAAA G VT Sbjct: 431 VYGAAIGRLFGETLS---------FIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH- 480 Query: 590 TVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKE 646 T+S ++ FE+TG + + +P++ AV+ + + + + Y+ + + P+L + Sbjct: 481 TISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRN 539 Query: 647 EFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGF 706 +H M + + L +D M ++++ ++ T +P++ S ESQ LVG Sbjct: 540 IGSHRVRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGI 593 Query: 707 ALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766 R L +++ + + + C + P LKL + T Sbjct: 594 VRRAQL---VQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKL-----------SPET 639 Query: 767 PMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809 + ++F L L VT GR +G ++ ++ + ++ N Sbjct: 640 SLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTN 682 >gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] Length = 687 Score = 178 bits (452), Expect = 2e-44 Identities = 165/643 (25%), Positives = 281/643 (43%), Gaps = 87/643 (13%) Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265 S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G I+ YL K Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147 Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317 + L LA S L LGK GP VH++ I +YL +T N++K+ E+L AA Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204 Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373 +A GV+ F AP GVLFS+E +S +F ++ WR FFAA AF+ R + F + + Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264 Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425 L P+ L E+F F+ LG G+ ++ + K+ ++ Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324 Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483 Y L +++A+IT +P S L + D SL D N A Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371 Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532 + P P + W+ L L+ K M + I +P+G F+P Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431 Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590 +GA GR++G A+ F E G + I PG YA+ GAAA G VT T Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481 Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647 +S ++ FELTG + + +P++ AV+ + + + + Y+ I + P+L + Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540 Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707 +H M + + L +D ++++ ++ T +P++ S ESQ LVG Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594 Query: 708 LRRDLTIAIES-ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766 R L A+++ + G + A+ P+ P T+ T Sbjct: 595 QRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPV---------------TLTLFSET 639 Query: 767 PMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809 + ++F+ L L+ VT GR +G ++ ++ + ++ N Sbjct: 640 TLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682 >gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] Length = 353 Score = 114 bits (286), Expect = 3e-25 Identities = 80/246 (32%), Positives = 120/246 (48%), Gaps = 46/246 (18%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W+VV G+ +G + +D T LK G+ +T+ EE C Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297 +G + G + TL+ K + ++ +VA GL +GKEGP++H G Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226 Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357 + FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++ Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285 Query: 358 VAAFVL 363 A F L Sbjct: 286 SATFTL 291 >gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] Length = 308 Score = 69.3 bits (168), Expect = 1e-11 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W+VV G+ +G + +D T LK G+ +T+ EE C Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308 +G + G + TL+ K + ++ +VA GL +GKEGP++H G++ P++ + Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222 Query: 309 KK 310 +K Sbjct: 223 RK 224 >gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] Length = 320 Score = 69.3 bits (168), Expect = 1e-11 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%) Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188 W+VV G+ +G + +D T LK G+ +T+ EE C Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121 Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248 Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166 Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308 +G + G + TL+ K + ++ +VA GL +GKEGP++H G++ P++ + Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222 Query: 309 KK 310 +K Sbjct: 223 RK 224 >gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] Length = 465 Score = 32.0 bits (71), Expect = 2.4 Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 22/119 (18%) Query: 511 IIMTVFTF-GIKVPSGLFIPSMAIGAIAGRIV----GIAVEQLAYYHHDWFIFKEWCEVG 565 +I+ VFT +K P LF+ S+A I + +A E + Y W+ K WCE+ Sbjct: 69 VIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY----WYFGKAWCEI- 123 Query: 566 ADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP----LMAAVMTSKWV 620 Y + C + + + + +T +EY + + A++ + WV Sbjct: 124 --------YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWV 174 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.139 0.433 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,155,038 Number of Sequences: 37866 Number of extensions: 1293082 Number of successful extensions: 2789 Number of sequences better than 10.0: 18 Number of HSP's better than 10.0 without gapping: 17 Number of HSP's successfully gapped in prelim test: 1 Number of HSP's that attempted gapping in prelim test: 2712 Number of HSP's gapped (non-prelim): 26 length of query: 818 length of database: 18,247,518 effective HSP length: 111 effective length of query: 707 effective length of database: 14,044,392 effective search space: 9929385144 effective search space used: 9929385144 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.