Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 54607020

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
         (610 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa...  1219   0.0  
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa...  1208   0.0  
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s...   213   3e-55
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     213   4e-55
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]     211   1e-54
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]    211   1e-54
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     202   1e-51
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     202   1e-51
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]              196   7e-50
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   191   1e-48
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   191   1e-48
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   191   1e-48
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   191   1e-48
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   188   1e-47
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   187   2e-47
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   187   2e-47
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   186   5e-47
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   186   5e-47
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   186   5e-47
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   186   5e-47
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   186   5e-47
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   186   5e-47
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   186   5e-47
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   186   5e-47
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   181   2e-45
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   181   2e-45
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   181   2e-45
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   180   3e-45
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   179   7e-45
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   177   3e-44

>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
           sapiens]
          Length = 610

 Score = 1219 bits (3153), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 1   MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
           MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1   MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60

Query: 61  GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
           GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61  GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120

Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
           YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180

Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
           KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240

Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
           FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300

Query: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
           YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK
Sbjct: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360

Query: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
           EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG
Sbjct: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420

Query: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
           NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL
Sbjct: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480

Query: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
           QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT
Sbjct: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540

Query: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
           LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
Sbjct: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600

Query: 601 EFHAALGAYV 610
           EFHAALGAYV
Sbjct: 601 EFHAALGAYV 610


>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
           sapiens]
          Length = 607

 Score = 1208 bits (3125), Expect = 0.0
 Identities = 607/610 (99%), Positives = 607/610 (99%), Gaps = 3/610 (0%)

Query: 1   MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
           MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1   MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60

Query: 61  GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
           GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61  GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120

Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
           YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180

Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
           KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240

Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
           FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS   
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS--- 297

Query: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
           YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK
Sbjct: 298 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 357

Query: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
           EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG
Sbjct: 358 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 417

Query: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
           NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL
Sbjct: 418 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 477

Query: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
           QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT
Sbjct: 478 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 537

Query: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
           LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
Sbjct: 538 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 597

Query: 601 EFHAALGAYV 610
           EFHAALGAYV
Sbjct: 598 EFHAALGAYV 607


>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
            sapiens]
          Length = 1400

 Score =  213 bits (543), Expect = 3e-55
 Identities = 123/312 (39%), Positives = 178/312 (57%), Gaps = 20/312 (6%)

Query: 302  PTLR---IEKNDLRSVTLLEAKGKVKDIAISRERITLKD--VLQEGTFGRIFHGILIDEK 356
            P LR   I+  DL S  L E    VKD+ I  ER+      V+ +G FG ++HG  ID+ 
Sbjct: 1050 PLLRKESIQLRDLDSALLAE----VKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQA 1105

Query: 357  DPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPY 416
                  Q  +K++       QV   L E   +RGL+H N+L +  + +     P V+LPY
Sbjct: 1106 Q--NRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPY 1163

Query: 417  MNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVI 476
            M  G+L  F+R  +     NP     +DL+   +Q+A GM YLA ++ +H+DLAARNC++
Sbjct: 1164 MCHGDLLQFIRSPQ----RNPTV---KDLISFGLQVARGMEYLAEQKFVHRDLAARNCML 1216

Query: 477  DDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAFGVT 534
            D++  VK+ D  L+RD+   +Y+ +  + +   PV+WMALESL    F++ SDVW+FGV 
Sbjct: 1217 DESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVL 1276

Query: 535  LWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQ 594
            LWEL+T G  PY  IDPF++  +L  G R+ QP  CPD L+ VM  CW  DP  RP F+ 
Sbjct: 1277 LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRV 1336

Query: 595  LVQCLTEFHAAL 606
            LV  + +  +AL
Sbjct: 1337 LVGEVEQIVSAL 1348


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  213 bits (542), Expect = 4e-55
 Identities = 115/283 (40%), Positives = 168/283 (59%), Gaps = 9/283 (3%)

Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEI 376
           E + K++D+ I R  + L  +L EG FG +  G L  E D    K A VKT+K D +S+ 
Sbjct: 572 ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQE-DGTSLKVA-VKTMKLDNSSQR 629

Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGE----KPMVILPYMNWGNLKLFLRQCKLV 432
           ++   L+E+  ++   H N++ +  VCIE       KPMVILP+M +G+L  +L   +L 
Sbjct: 630 EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL- 688

Query: 433 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 492
               P+ I  Q L+   + IA GM YL+ R  +H+DLAARNC++ D + V + D  LS+ 
Sbjct: 689 -ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 747

Query: 493 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 552
           ++  DY+  G     PV+W+A+ESL +  ++S SDVWAFGVT+WE+ T G TPY  +   
Sbjct: 748 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH 807

Query: 553 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQL 595
           EM  YL  G+R+ QP +C DEL+ +M  CW  DP +RP F  L
Sbjct: 808 EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850


>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
          Length = 1390

 Score =  211 bits (538), Expect = 1e-54
 Identities = 127/365 (34%), Positives = 192/365 (52%), Gaps = 38/365 (10%)

Query: 260  LDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGY------------PTLRIE 307
            LD  +SA S S      S ++  Y RA  P +  P +S  G             P L   
Sbjct: 980  LDRLVSARSVSPTTEMVSNESVDY-RATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSG 1038

Query: 308  KNDLRSVTLL------------EAKGKVKDIAISRERITL--KDVLQEGTFGRIFHGILI 353
             +D+ S  L             E    V+ + I    + +   +V+  G FG ++HG L+
Sbjct: 1039 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLL 1098

Query: 354  DEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVI 413
            D  +  K+    VK++       +V+  LTE   ++   H N+L +  +C+     P+V+
Sbjct: 1099 D--NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV 1156

Query: 414  LPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARN 473
            LPYM  G+L+ F+R     E +NP     +DL+   +Q+A GM YLA ++ +H+DLAARN
Sbjct: 1157 LPYMKHGDLRNFIRN----ETHNPTV---KDLIGFGLQVAKGMKYLASKKFVHRDLAARN 1209

Query: 474  CVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAF 531
            C++D+   VK+ D  L+RD++  +Y+ + +      PV+WMALESL   +F++ SDVW+F
Sbjct: 1210 CMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 1269

Query: 532  GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPK 591
            GV LWELMT G  PY D++ F++  YL  G R+ QP  CPD L+ VM  CW    E RP 
Sbjct: 1270 GVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPS 1329

Query: 592  FQQLV 596
            F +LV
Sbjct: 1330 FSELV 1334


>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
          Length = 1408

 Score =  211 bits (538), Expect = 1e-54
 Identities = 127/365 (34%), Positives = 192/365 (52%), Gaps = 38/365 (10%)

Query: 260  LDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGY------------PTLRIE 307
            LD  +SA S S      S ++  Y RA  P +  P +S  G             P L   
Sbjct: 998  LDRLVSARSVSPTTEMVSNESVDY-RATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSG 1056

Query: 308  KNDLRSVTLL------------EAKGKVKDIAISRERITL--KDVLQEGTFGRIFHGILI 353
             +D+ S  L             E    V+ + I    + +   +V+  G FG ++HG L+
Sbjct: 1057 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLL 1116

Query: 354  DEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVI 413
            D  +  K+    VK++       +V+  LTE   ++   H N+L +  +C+     P+V+
Sbjct: 1117 D--NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV 1174

Query: 414  LPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARN 473
            LPYM  G+L+ F+R     E +NP     +DL+   +Q+A GM YLA ++ +H+DLAARN
Sbjct: 1175 LPYMKHGDLRNFIRN----ETHNPTV---KDLIGFGLQVAKGMKYLASKKFVHRDLAARN 1227

Query: 474  CVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAF 531
            C++D+   VK+ D  L+RD++  +Y+ + +      PV+WMALESL   +F++ SDVW+F
Sbjct: 1228 CMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 1287

Query: 532  GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPK 591
            GV LWELMT G  PY D++ F++  YL  G R+ QP  CPD L+ VM  CW    E RP 
Sbjct: 1288 GVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPS 1347

Query: 592  FQQLV 596
            F +LV
Sbjct: 1348 FSELV 1352


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  202 bits (513), Expect = 1e-51
 Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)

Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 376
           E K K++D+ + R ++ L   L EG FG +  G L   +D +  K A VKT+K    +  
Sbjct: 512 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 568

Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 431
           ++   L+E+  ++   H N++ +  VC +  E+     P+VILP+M  G+L  FL   +L
Sbjct: 569 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 628

Query: 432 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 491
              + P  +  Q LV     IA GM YL+ +  IH+DLAARNC++++ + V + D  LS+
Sbjct: 629 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 686

Query: 492 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 551
            ++  DY+  G     PV+W+A+ESL +  ++S SDVW+FGVT+WE+ T GQTPY  ++ 
Sbjct: 687 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 746

Query: 552 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 606
            E+  YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L     AL
Sbjct: 747 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 801


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  202 bits (513), Expect = 1e-51
 Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)

Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 376
           E K K++D+ + R ++ L   L EG FG +  G L   +D +  K A VKT+K    +  
Sbjct: 521 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 577

Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 431
           ++   L+E+  ++   H N++ +  VC +  E+     P+VILP+M  G+L  FL   +L
Sbjct: 578 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 637

Query: 432 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 491
              + P  +  Q LV     IA GM YL+ +  IH+DLAARNC++++ + V + D  LS+
Sbjct: 638 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 695

Query: 492 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 551
            ++  DY+  G     PV+W+A+ESL +  ++S SDVW+FGVT+WE+ T GQTPY  ++ 
Sbjct: 696 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 755

Query: 552 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 606
            E+  YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L     AL
Sbjct: 756 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 810


>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
          Length = 890

 Score =  196 bits (497), Expect = 7e-50
 Identities = 107/280 (38%), Positives = 160/280 (57%), Gaps = 8/280 (2%)

Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQ 377
           E K K++D+ I  ++ TL  +L +G FG +    L  E D +  K A      D  +   
Sbjct: 503 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE-DGSFVKVAVKMLKADIIASSD 561

Query: 378 VTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKLV 432
           +   L E+  ++   H ++  +  V +    K     PMVILP+M  G+L  FL   ++ 
Sbjct: 562 IEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIG 621

Query: 433 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 492
           E  NP  +  Q L+   + IACGM YL+ R  IH+DLAARNC++ + + V + D  LSR 
Sbjct: 622 E--NPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 679

Query: 493 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 552
           ++  DY+  G     PV+W+ALESL +N ++  SDVWAFGVT+WE+MT GQTPY  I+  
Sbjct: 680 IYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA 739

Query: 553 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 592
           E+  YL  G R+ QP  C ++++ +M  CW+ DP++RP F
Sbjct: 740 EIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF 779



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 27/65 (41%), Positives = 29/65 (44%), Gaps = 8/65 (12%)

Query: 7  LGRPGRSCLPGARGLRAPPPPPLLLLLALLP--LLPAPGAAAAPAPRPPELQSASAGPSV 64
          +GRPG   LP       PPPP L LLLA L   LLP   AA       P   + S G  V
Sbjct: 7  MGRPGLPPLP------LPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60

Query: 65 SLYLS 69
           L  S
Sbjct: 61 KLNCS 65


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)

Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
           T+ + +   P   T   Y+ + + C   FL++ ++  + ++ MK         +  +   
Sbjct: 266 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 325

Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
           L++ S    + +     ++A+  +  L     R+  +    +  +      +D    + R
Sbjct: 326 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 384

Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
           +R+ L   L EG FG++     I +D+  PN+  +  VK +K  A+E  ++ +++E   +
Sbjct: 385 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 444

Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
           + +  H+N++ +   C ++G    VI+ Y + GNL+ +L+         C     N  + 
Sbjct: 445 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 503

Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
           +S +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+
Sbjct: 504 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 563

Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
               N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  +   E+   LK
Sbjct: 564 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 623

Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +G+R+ +P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 624 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)

Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
           T+ + +   P   T   Y+ + + C   FL++ ++  + ++ MK         +  +   
Sbjct: 268 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327

Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
           L++ S    + +     ++A+  +  L     R+  +    +  +      +D    + R
Sbjct: 328 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 386

Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
           +R+ L   L EG FG++     I +D+  PN+  +  VK +K  A+E  ++ +++E   +
Sbjct: 387 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 446

Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
           + +  H+N++ +   C ++G    VI+ Y + GNL+ +L+         C     N  + 
Sbjct: 447 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505

Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
           +S +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+
Sbjct: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565

Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
               N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  +   E+   LK
Sbjct: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625

Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +G+R+ +P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)

Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
           T+ + +   P   T   Y+ + + C   FL++ ++  + ++ MK         +  +   
Sbjct: 355 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 414

Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
           L++ S    + +     ++A+  +  L     R+  +    +  +      +D    + R
Sbjct: 415 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 473

Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
           +R+ L   L EG FG++     I +D+  PN+  +  VK +K  A+E  ++ +++E   +
Sbjct: 474 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 533

Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
           + +  H+N++ +   C ++G    VI+ Y + GNL+ +L+         C     N  + 
Sbjct: 534 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 592

Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
           +S +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+
Sbjct: 593 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 652

Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
               N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  +   E+   LK
Sbjct: 653 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 712

Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +G+R+ +P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 713 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 752


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)

Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
           T+ + +   P   T   Y+ + + C   FL++ ++  + ++ MK         +  +   
Sbjct: 357 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 416

Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
           L++ S    + +     ++A+  +  L     R+  +    +  +      +D    + R
Sbjct: 417 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 475

Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
           +R+ L   L EG FG++     I +D+  PN+  +  VK +K  A+E  ++ +++E   +
Sbjct: 476 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 535

Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
           + +  H+N++ +   C ++G    VI+ Y + GNL+ +L+         C     N  + 
Sbjct: 536 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 594

Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
           +S +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+
Sbjct: 595 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654

Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
               N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  +   E+   LK
Sbjct: 655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 714

Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +G+R+ +P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 715 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score =  188 bits (478), Expect = 1e-47
 Identities = 118/383 (30%), Positives = 204/383 (53%), Gaps = 15/383 (3%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQ--PSTQTTQYLRAD 287
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++  P  +      + 
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSS 319

Query: 288 TPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRI 347
           + N+ TP+       +   +   L  V+  E     K     R+++TL   L EG FG++
Sbjct: 320 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFGQV 378

Query: 348 F--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCI 404
                + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+N++ +   C 
Sbjct: 379 VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT 438

Query: 405 EEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIACGM 456
           ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV    Q+A GM
Sbjct: 439 QDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 497

Query: 457 SYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALES 516
            YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N   PV+WMA E+
Sbjct: 498 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEA 557

Query: 517 LVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFA 576
           L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +P NC +EL+ 
Sbjct: 558 LFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM 617

Query: 577 VMACCWALDPEERPKFQQLVQCL 599
           +M  CW   P +RP F+QLV+ L
Sbjct: 618 MMRDCWHAVPSQRPTFKQLVEDL 640


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  187 bits (476), Expect = 2e-47
 Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)

Query: 328  ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
            +SRE+ITL   L +G+FG ++ G   D      E +  VKTV + AS  +    L E+  
Sbjct: 1006 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1065

Query: 388  LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 445
            ++G    +++ +  V + +G+  +V++  M  G+LK +LR  +    NNP     + Q++
Sbjct: 1066 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1124

Query: 446  VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
            + MA +IA GM+YL  ++ +H+DLAARNC++     VKI D  ++RD++  DY+  G   
Sbjct: 1125 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1184

Query: 506  NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
              PVRWMA ESL +  F+++SD+W+FGV LWE+ +L + PY  +   ++  ++ DG  + 
Sbjct: 1185 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1244

Query: 566  QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
            QP NCP+ +  +M  CW  +P+ RP F ++V  L +
Sbjct: 1245 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1280


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  187 bits (476), Expect = 2e-47
 Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)

Query: 328  ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
            +SRE+ITL   L +G+FG ++ G   D      E +  VKTV + AS  +    L E+  
Sbjct: 1018 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1077

Query: 388  LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 445
            ++G    +++ +  V + +G+  +V++  M  G+LK +LR  +    NNP     + Q++
Sbjct: 1078 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1136

Query: 446  VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
            + MA +IA GM+YL  ++ +H+DLAARNC++     VKI D  ++RD++  DY+  G   
Sbjct: 1137 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1196

Query: 506  NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
              PVRWMA ESL +  F+++SD+W+FGV LWE+ +L + PY  +   ++  ++ DG  + 
Sbjct: 1197 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256

Query: 566  QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
            QP NCP+ +  +M  CW  +P+ RP F ++V  L +
Sbjct: 1257 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1292


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 287 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 346

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 347 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 397

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 398 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 458 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 516

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 517 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 576

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 577 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 636

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 637 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 669


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 486

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 487 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 547 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  186 bits (472), Expect = 5e-47
 Identities = 95/276 (34%), Positives = 161/276 (58%), Gaps = 3/276 (1%)

Query: 328  ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
            ++RE+IT+   L +G+FG ++ G+         E +  +KTV + AS  +    L E+  
Sbjct: 994  VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV 1053

Query: 388  LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAI--SQQDL 445
            ++  +  +++ +  V + +G+  +VI+  M  G+LK +LR  +    NNP     S   +
Sbjct: 1054 MKEFNCHHVVRLLGV-VSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112

Query: 446  VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
            + MA +IA GM+YL   + +H+DLAARNC++ +   VKI D  ++RD++  DY+  G   
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172

Query: 506  NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
              PVRWM+ ESL +  F++ SDVW+FGV LWE+ TL + PY  +   ++  ++ +G  + 
Sbjct: 1173 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLD 1232

Query: 566  QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
            +P NCPD LF +M  CW  +P+ RP F +++  + E
Sbjct: 1233 KPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 1268


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 319

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 320 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 370

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 371 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 431 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 489

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 490 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 549

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 550 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 609

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 610 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 286 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 345

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 346 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 396

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 397 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 457 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 515

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 516 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 575

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 576 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 635

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 636 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 263 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 322

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 323 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 373

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 374 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 434 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 375 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 434

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 435 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 485

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 486 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 545

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 546 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 604

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 605 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 664

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 665 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 724

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 725 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  186 bits (472), Expect = 5e-47
 Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
           Y+ + + C  +FL+A ++  + L  MK        S+  +   L++          S ++
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435

Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
           +  + ++TP     T ++S+   P L  + + +L      E           R+++TL  
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 486

Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
            L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   ++ +  H+
Sbjct: 487 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546

Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
           N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     + ++ +DLV
Sbjct: 547 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605

Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
               Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+    N  
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665

Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
            PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   LK+G+R+ +
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725

Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  181 bits (458), Expect = 2e-45
 Identities = 132/398 (33%), Positives = 203/398 (51%), Gaps = 29/398 (7%)

Query: 218 VHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLS-QP 276
           V A    S     +S GV   +  LV   + +  L S  +  L        S   L  Q 
Sbjct: 366 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 425

Query: 277 STQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLK 336
           S ++   + ++TP       SS   PTL        +V+ LE     K   +SR R+TL 
Sbjct: 426 SLESNASMSSNTPLVRIARLSSGEGPTLA-------NVSELELPADPK-WELSRARLTLG 477

Query: 337 DVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HH 393
             L EG FG++     I ID+    K     VK +KD A++  ++ +++E   ++ +  H
Sbjct: 478 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 537

Query: 394 RNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ------------CKLVEANNPQAIS 441
           +N++ +   C + G    V++ Y   GNL+ FLR             CK  E    + ++
Sbjct: 538 KNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPE----EQLT 592

Query: 442 QQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 501
            +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+  
Sbjct: 593 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 652

Query: 502 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG 561
             N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  I   E+   LK+G
Sbjct: 653 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 712

Query: 562 YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +R+ +P NC  +L+ +M  CW   P +RP F+QLV+ L
Sbjct: 713 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  181 bits (458), Expect = 2e-45
 Identities = 123/370 (33%), Positives = 197/370 (53%), Gaps = 38/370 (10%)

Query: 251 HLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGYPTLRI---- 306
           H+  +K +E++ S         +    T     L+    +NA+  +++   P +RI    
Sbjct: 284 HIQWLKHVEVNGS--------KVGPDGTPYVTVLKVSLESNASMSSNT---PLVRIARLS 332

Query: 307 --EKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIF--HGILIDEKDPNKEK 362
             E   L +V+ LE     K   +SR R+TL   L EG FG++     I ID+    K  
Sbjct: 333 SGEGPTLANVSELELPADPK-WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 391

Query: 363 QAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGN 421
              VK +KD A++  ++ +++E   ++ +  H+N++ +   C + G    V++ Y   GN
Sbjct: 392 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-YVLVEYAAKGN 450

Query: 422 LKLFLRQ------------CKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDL 469
           L+ FLR             CK  E    + ++ +DLV  A Q+A GM YLA ++ IH+DL
Sbjct: 451 LREFLRARRPPGLDYSFDTCKPPE----EQLTFKDLVSCAYQVARGMEYLASQKCIHRDL 506

Query: 470 AARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVW 529
           AARN ++ +   +KI D  L+RD+  +DY+    N   PV+WMA E+L +  ++  SDVW
Sbjct: 507 AARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 566

Query: 530 AFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEER 589
           +FGV LWE+ TLG +PY  I   E+   LK+G+R+ +P NC  +L+ +M  CW   P +R
Sbjct: 567 SFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQR 626

Query: 590 PKFQQLVQCL 599
           P F+QLV+ L
Sbjct: 627 PTFKQLVEDL 636


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  181 bits (458), Expect = 2e-45
 Identities = 132/398 (33%), Positives = 203/398 (51%), Gaps = 29/398 (7%)

Query: 218 VHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLS-QP 276
           V A    S     +S GV   +  LV   + +  L S  +  L        S   L  Q 
Sbjct: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 423

Query: 277 STQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLK 336
           S ++   + ++TP       SS   PTL        +V+ LE     K   +SR R+TL 
Sbjct: 424 SLESNASMSSNTPLVRIARLSSGEGPTLA-------NVSELELPADPK-WELSRARLTLG 475

Query: 337 DVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HH 393
             L EG FG++     I ID+    K     VK +KD A++  ++ +++E   ++ +  H
Sbjct: 476 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 535

Query: 394 RNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ------------CKLVEANNPQAIS 441
           +N++ +   C + G    V++ Y   GNL+ FLR             CK  E    + ++
Sbjct: 536 KNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPE----EQLT 590

Query: 442 QQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 501
            +DLV  A Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY+  
Sbjct: 591 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 650

Query: 502 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG 561
             N   PV+WMA E+L +  ++  SDVW+FGV LWE+ TLG +PY  I   E+   LK+G
Sbjct: 651 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 710

Query: 562 YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           +R+ +P NC  +L+ +M  CW   P +RP F+QLV+ L
Sbjct: 711 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  180 bits (457), Expect = 3e-45
 Identities = 113/387 (29%), Positives = 187/387 (48%), Gaps = 8/387 (2%)

Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTP 289
           Y  V +   V F + ++L +L L    +  +    S  S+    + P    +      + 
Sbjct: 434 YAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSS 493

Query: 290 NNATPITSSLGYPTLRIEKN-DLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIF 348
           +   P    +G   + + +N     +T  + K       I R  I LK  L EG FG++F
Sbjct: 494 SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVF 553

Query: 349 HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE 408
                +      +    VKT+KD AS+        E+  L  L H +++    VC+E G+
Sbjct: 554 LAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVE-GD 611

Query: 409 KPMVILPYMNWGNLKLFLRQ-----CKLVEANNPQAISQQDLVHMAIQIACGMSYLARRE 463
             +++  YM  G+L  FLR        + E N P  ++Q  ++H+A QIA GM YLA + 
Sbjct: 612 PLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH 671

Query: 464 VIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFS 523
            +H+DLA RNC++ + L VKI D  +SRD++  DY+ +G +   P+RWM  ES++  +F+
Sbjct: 672 FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT 731

Query: 524 SASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWA 583
           + SDVW+ GV LWE+ T G+ P+  +   E+   +  G  + +P  CP E++ +M  CW 
Sbjct: 732 TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQ 791

Query: 584 LDPEERPKFQQLVQCLTEFHAALGAYV 610
            +P  R   + +   L     A   Y+
Sbjct: 792 REPHMRKNIKGIHTLLQNLAKASPVYL 818


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  179 bits (454), Expect = 7e-45
 Identities = 100/281 (35%), Positives = 166/281 (59%), Gaps = 12/281 (4%)

Query: 330 RERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
           R+++TL   L EG FG++     + ID+  P +     VK +KD A+E  ++ +++E   
Sbjct: 362 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 421

Query: 388 LRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQ 438
           ++ +  H+N++ +   C ++G    VI+ Y + GNL+ +LR  +         +     +
Sbjct: 422 MKMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480

Query: 439 AISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDY 498
            ++ +DLV    Q+A GM YLA ++ IH+DLAARN ++ +   +KI D  L+RD+  +DY
Sbjct: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540

Query: 499 HCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYL 558
           +    N   PV+WMA E+L +  ++  SDVW+FGV +WE+ TLG +PY  I   E+   L
Sbjct: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600

Query: 559 KDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
           K+G+R+ +P NC +EL+ +M  CW   P +RP F+QLV+ L
Sbjct: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 641


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  177 bits (449), Expect = 3e-44
 Identities = 100/282 (35%), Positives = 158/282 (56%), Gaps = 8/282 (2%)

Query: 327  AISRERITLKDVLQEGTFGRIFHGILIDEKDPNK-EKQAFVKTVKDQASEIQVTMMLTES 385
            A  RE++TL+ +L  G FG ++ G  +D       E +  VKT+K  +++ +    L E+
Sbjct: 1939 AFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 1998

Query: 386  CKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDL 445
              +   +H N+L    VC+   E   +IL  M  G+L  +LR+ ++     P  ++  DL
Sbjct: 1999 HLMSKFNHPNILKQLGVCLLN-EPQYIILELMEGGDLLTYLRKARMATFYGP-LLTLVDL 2056

Query: 446  VHMAIQIACGMSYLARREVIHKDLAARNCVID-----DTLQVKITDNALSRDLFPMDYHC 500
            V + + I+ G  YL R   IH+DLAARNC++          VKI D  L+RD++  DY+ 
Sbjct: 2057 VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYR 2116

Query: 501  LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKD 560
                   PVRWMA ESL++  F++ SDVW+FG+ +WE++TLG  PY      ++  Y++ 
Sbjct: 2117 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 2176

Query: 561  GYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 602
            G R+  P NCPD+L+ +M  CWA +P++RP F ++   L  F
Sbjct: 2177 GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,336,639
Number of Sequences: 37866
Number of extensions: 1131751
Number of successful extensions: 10400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 447
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 8029
Number of HSP's gapped (non-prelim): 2015
length of query: 610
length of database: 18,247,518
effective HSP length: 108
effective length of query: 502
effective length of database: 14,157,990
effective search space: 7107310980
effective search space used: 7107310980
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press