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Search of human proteins with 54607020
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
(610 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa... 1219 0.0
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa... 1208 0.0
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 213 3e-55
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 213 4e-55
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens] 211 1e-54
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens] 211 1e-54
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 202 1e-51
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 202 1e-51
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 196 7e-50
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 191 1e-48
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 191 1e-48
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 191 1e-48
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 191 1e-48
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 188 1e-47
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 187 2e-47
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 187 2e-47
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 186 5e-47
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 186 5e-47
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 186 5e-47
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 186 5e-47
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 186 5e-47
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 186 5e-47
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 186 5e-47
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 186 5e-47
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 181 2e-45
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 181 2e-45
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 181 2e-45
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 180 3e-45
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 179 7e-45
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 177 3e-44
>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
Length = 610
Score = 1219 bits (3153), Expect = 0.0
Identities = 610/610 (100%), Positives = 610/610 (100%)
Query: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
Query: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
Query: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK
Sbjct: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
Query: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG
Sbjct: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
Query: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL
Sbjct: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
Query: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT
Sbjct: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
Query: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
Sbjct: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
Query: 601 EFHAALGAYV 610
EFHAALGAYV
Sbjct: 601 EFHAALGAYV 610
>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
sapiens]
Length = 607
Score = 1208 bits (3125), Expect = 0.0
Identities = 607/610 (99%), Positives = 607/610 (99%), Gaps = 3/610 (0%)
Query: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
Query: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS--- 297
Query: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK
Sbjct: 298 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 357
Query: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG
Sbjct: 358 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 417
Query: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL
Sbjct: 418 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 477
Query: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT
Sbjct: 478 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 537
Query: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
Sbjct: 538 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 597
Query: 601 EFHAALGAYV 610
EFHAALGAYV
Sbjct: 598 EFHAALGAYV 607
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 213 bits (543), Expect = 3e-55
Identities = 123/312 (39%), Positives = 178/312 (57%), Gaps = 20/312 (6%)
Query: 302 PTLR---IEKNDLRSVTLLEAKGKVKDIAISRERITLKD--VLQEGTFGRIFHGILIDEK 356
P LR I+ DL S L E VKD+ I ER+ V+ +G FG ++HG ID+
Sbjct: 1050 PLLRKESIQLRDLDSALLAE----VKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQA 1105
Query: 357 DPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPY 416
Q +K++ QV L E +RGL+H N+L + + + P V+LPY
Sbjct: 1106 Q--NRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPY 1163
Query: 417 MNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVI 476
M G+L F+R + NP +DL+ +Q+A GM YLA ++ +H+DLAARNC++
Sbjct: 1164 MCHGDLLQFIRSPQ----RNPTV---KDLISFGLQVARGMEYLAEQKFVHRDLAARNCML 1216
Query: 477 DDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAFGVT 534
D++ VK+ D L+RD+ +Y+ + + + PV+WMALESL F++ SDVW+FGV
Sbjct: 1217 DESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVL 1276
Query: 535 LWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQ 594
LWEL+T G PY IDPF++ +L G R+ QP CPD L+ VM CW DP RP F+
Sbjct: 1277 LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRV 1336
Query: 595 LVQCLTEFHAAL 606
LV + + +AL
Sbjct: 1337 LVGEVEQIVSAL 1348
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 213 bits (542), Expect = 4e-55
Identities = 115/283 (40%), Positives = 168/283 (59%), Gaps = 9/283 (3%)
Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEI 376
E + K++D+ I R + L +L EG FG + G L E D K A VKT+K D +S+
Sbjct: 572 ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQE-DGTSLKVA-VKTMKLDNSSQR 629
Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGE----KPMVILPYMNWGNLKLFLRQCKLV 432
++ L+E+ ++ H N++ + VCIE KPMVILP+M +G+L +L +L
Sbjct: 630 EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL- 688
Query: 433 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 492
P+ I Q L+ + IA GM YL+ R +H+DLAARNC++ D + V + D LS+
Sbjct: 689 -ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 747
Query: 493 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 552
++ DY+ G PV+W+A+ESL + ++S SDVWAFGVT+WE+ T G TPY +
Sbjct: 748 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH 807
Query: 553 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQL 595
EM YL G+R+ QP +C DEL+ +M CW DP +RP F L
Sbjct: 808 EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850
>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
Length = 1390
Score = 211 bits (538), Expect = 1e-54
Identities = 127/365 (34%), Positives = 192/365 (52%), Gaps = 38/365 (10%)
Query: 260 LDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGY------------PTLRIE 307
LD +SA S S S ++ Y RA P + P +S G P L
Sbjct: 980 LDRLVSARSVSPTTEMVSNESVDY-RATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSG 1038
Query: 308 KNDLRSVTLL------------EAKGKVKDIAISRERITL--KDVLQEGTFGRIFHGILI 353
+D+ S L E V+ + I + + +V+ G FG ++HG L+
Sbjct: 1039 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLL 1098
Query: 354 DEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVI 413
D + K+ VK++ +V+ LTE ++ H N+L + +C+ P+V+
Sbjct: 1099 D--NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV 1156
Query: 414 LPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARN 473
LPYM G+L+ F+R E +NP +DL+ +Q+A GM YLA ++ +H+DLAARN
Sbjct: 1157 LPYMKHGDLRNFIRN----ETHNPTV---KDLIGFGLQVAKGMKYLASKKFVHRDLAARN 1209
Query: 474 CVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAF 531
C++D+ VK+ D L+RD++ +Y+ + + PV+WMALESL +F++ SDVW+F
Sbjct: 1210 CMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 1269
Query: 532 GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPK 591
GV LWELMT G PY D++ F++ YL G R+ QP CPD L+ VM CW E RP
Sbjct: 1270 GVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPS 1329
Query: 592 FQQLV 596
F +LV
Sbjct: 1330 FSELV 1334
>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
Length = 1408
Score = 211 bits (538), Expect = 1e-54
Identities = 127/365 (34%), Positives = 192/365 (52%), Gaps = 38/365 (10%)
Query: 260 LDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGY------------PTLRIE 307
LD +SA S S S ++ Y RA P + P +S G P L
Sbjct: 998 LDRLVSARSVSPTTEMVSNESVDY-RATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSG 1056
Query: 308 KNDLRSVTLL------------EAKGKVKDIAISRERITL--KDVLQEGTFGRIFHGILI 353
+D+ S L E V+ + I + + +V+ G FG ++HG L+
Sbjct: 1057 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLL 1116
Query: 354 DEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVI 413
D + K+ VK++ +V+ LTE ++ H N+L + +C+ P+V+
Sbjct: 1117 D--NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV 1174
Query: 414 LPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARN 473
LPYM G+L+ F+R E +NP +DL+ +Q+A GM YLA ++ +H+DLAARN
Sbjct: 1175 LPYMKHGDLRNFIRN----ETHNPTV---KDLIGFGLQVAKGMKYLASKKFVHRDLAARN 1227
Query: 474 CVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAF 531
C++D+ VK+ D L+RD++ +Y+ + + PV+WMALESL +F++ SDVW+F
Sbjct: 1228 CMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 1287
Query: 532 GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPK 591
GV LWELMT G PY D++ F++ YL G R+ QP CPD L+ VM CW E RP
Sbjct: 1288 GVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPS 1347
Query: 592 FQQLV 596
F +LV
Sbjct: 1348 FSELV 1352
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 202 bits (513), Expect = 1e-51
Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)
Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 376
E K K++D+ + R ++ L L EG FG + G L +D + K A VKT+K +
Sbjct: 512 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 568
Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 431
++ L+E+ ++ H N++ + VC + E+ P+VILP+M G+L FL +L
Sbjct: 569 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 628
Query: 432 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 491
+ P + Q LV IA GM YL+ + IH+DLAARNC++++ + V + D LS+
Sbjct: 629 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 686
Query: 492 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 551
++ DY+ G PV+W+A+ESL + ++S SDVW+FGVT+WE+ T GQTPY ++
Sbjct: 687 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 746
Query: 552 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 606
E+ YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L AL
Sbjct: 747 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 801
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 202 bits (513), Expect = 1e-51
Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)
Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 376
E K K++D+ + R ++ L L EG FG + G L +D + K A VKT+K +
Sbjct: 521 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 577
Query: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 431
++ L+E+ ++ H N++ + VC + E+ P+VILP+M G+L FL +L
Sbjct: 578 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 637
Query: 432 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 491
+ P + Q LV IA GM YL+ + IH+DLAARNC++++ + V + D LS+
Sbjct: 638 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 695
Query: 492 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 551
++ DY+ G PV+W+A+ESL + ++S SDVW+FGVT+WE+ T GQTPY ++
Sbjct: 696 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 755
Query: 552 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 606
E+ YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L AL
Sbjct: 756 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 810
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 196 bits (497), Expect = 7e-50
Identities = 107/280 (38%), Positives = 160/280 (57%), Gaps = 8/280 (2%)
Query: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQ 377
E K K++D+ I ++ TL +L +G FG + L E D + K A D +
Sbjct: 503 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE-DGSFVKVAVKMLKADIIASSD 561
Query: 378 VTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKLV 432
+ L E+ ++ H ++ + V + K PMVILP+M G+L FL ++
Sbjct: 562 IEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIG 621
Query: 433 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 492
E NP + Q L+ + IACGM YL+ R IH+DLAARNC++ + + V + D LSR
Sbjct: 622 E--NPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 679
Query: 493 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 552
++ DY+ G PV+W+ALESL +N ++ SDVWAFGVT+WE+MT GQTPY I+
Sbjct: 680 IYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA 739
Query: 553 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 592
E+ YL G R+ QP C ++++ +M CW+ DP++RP F
Sbjct: 740 EIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF 779
Score = 33.5 bits (75), Expect = 0.59
Identities = 27/65 (41%), Positives = 29/65 (44%), Gaps = 8/65 (12%)
Query: 7 LGRPGRSCLPGARGLRAPPPPPLLLLLALLP--LLPAPGAAAAPAPRPPELQSASAGPSV 64
+GRPG LP PPPP L LLLA L LLP AA P + S G V
Sbjct: 7 MGRPGLPPLP------LPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60
Query: 65 SLYLS 69
L S
Sbjct: 61 KLNCS 65
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 191 bits (486), Expect = 1e-48
Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 266 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 325
Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
L++ S + + ++A+ + L R+ + + + +D + R
Sbjct: 326 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 384
Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 385 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 444
Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 445 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 503
Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 504 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 563
Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 564 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 623
Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 624 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 191 bits (486), Expect = 1e-48
Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 268 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327
Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
L++ S + + ++A+ + L R+ + + + +D + R
Sbjct: 328 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 386
Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 387 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 446
Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 447 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505
Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565
Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625
Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 191 bits (486), Expect = 1e-48
Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 355 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 414
Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
L++ S + + ++A+ + L R+ + + + +D + R
Sbjct: 415 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 473
Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 474 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 533
Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 534 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 592
Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 593 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 652
Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 653 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 712
Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 713 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 752
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 191 bits (486), Expect = 1e-48
Identities = 118/400 (29%), Positives = 211/400 (52%), Gaps = 15/400 (3%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 357 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 416
Query: 273 LSQPSTQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIA--ISR 330
L++ S + + ++A+ + L R+ + + + +D + R
Sbjct: 417 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 475
Query: 331 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 476 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 535
Query: 389 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 439
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 536 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 594
Query: 440 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 499
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 595 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654
Query: 500 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 559
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 714
Query: 560 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 715 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 188 bits (478), Expect = 1e-47
Identities = 118/383 (30%), Positives = 204/383 (53%), Gaps = 15/383 (3%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQ--PSTQTTQYLRAD 287
Y+ + + C +FL+A ++ + L MK S+ + L++ P + +
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSS 319
Query: 288 TPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRI 347
+ N+ TP+ + + L V+ E K R+++TL L EG FG++
Sbjct: 320 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFGQV 378
Query: 348 F--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCI 404
+ ID+ P + VK +KD A+E ++ +++E ++ + H+N++ + C
Sbjct: 379 VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT 438
Query: 405 EEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIACGM 456
++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A GM
Sbjct: 439 QDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 497
Query: 457 SYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALES 516
YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA E+
Sbjct: 498 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEA 557
Query: 517 LVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFA 576
L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL+
Sbjct: 558 LFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM 617
Query: 577 VMACCWALDPEERPKFQQLVQCL 599
+M CW P +RP F+QLV+ L
Sbjct: 618 MMRDCWHAVPSQRPTFKQLVEDL 640
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 187 bits (476), Expect = 2e-47
Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)
Query: 328 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
+SRE+ITL L +G+FG ++ G D E + VKTV + AS + L E+
Sbjct: 1006 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1065
Query: 388 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 445
++G +++ + V + +G+ +V++ M G+LK +LR + NNP + Q++
Sbjct: 1066 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1124
Query: 446 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
+ MA +IA GM+YL ++ +H+DLAARNC++ VKI D ++RD++ DY+ G
Sbjct: 1125 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1184
Query: 506 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
PVRWMA ESL + F+++SD+W+FGV LWE+ +L + PY + ++ ++ DG +
Sbjct: 1185 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1244
Query: 566 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
QP NCP+ + +M CW +P+ RP F ++V L +
Sbjct: 1245 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1280
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 187 bits (476), Expect = 2e-47
Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)
Query: 328 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
+SRE+ITL L +G+FG ++ G D E + VKTV + AS + L E+
Sbjct: 1018 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1077
Query: 388 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 445
++G +++ + V + +G+ +V++ M G+LK +LR + NNP + Q++
Sbjct: 1078 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1136
Query: 446 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
+ MA +IA GM+YL ++ +H+DLAARNC++ VKI D ++RD++ DY+ G
Sbjct: 1137 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1196
Query: 506 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
PVRWMA ESL + F+++SD+W+FGV LWE+ +L + PY + ++ ++ DG +
Sbjct: 1197 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256
Query: 566 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
QP NCP+ + +M CW +P+ RP F ++V L +
Sbjct: 1257 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1292
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 287 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 346
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 347 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 397
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 398 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 458 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 516
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 517 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 576
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 577 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 636
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 637 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 669
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 486
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 487 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 547 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 186 bits (472), Expect = 5e-47
Identities = 95/276 (34%), Positives = 161/276 (58%), Gaps = 3/276 (1%)
Query: 328 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
++RE+IT+ L +G+FG ++ G+ E + +KTV + AS + L E+
Sbjct: 994 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV 1053
Query: 388 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAI--SQQDL 445
++ + +++ + V + +G+ +VI+ M G+LK +LR + NNP S +
Sbjct: 1054 MKEFNCHHVVRLLGV-VSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112
Query: 446 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 505
+ MA +IA GM+YL + +H+DLAARNC++ + VKI D ++RD++ DY+ G
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172
Query: 506 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565
PVRWM+ ESL + F++ SDVW+FGV LWE+ TL + PY + ++ ++ +G +
Sbjct: 1173 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLD 1232
Query: 566 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 601
+P NCPD LF +M CW +P+ RP F +++ + E
Sbjct: 1233 KPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 1268
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 319
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 320 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 370
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 371 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 431 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 489
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 490 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 549
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 550 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 609
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 610 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 286 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 345
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 346 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 396
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 397 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 457 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 515
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 516 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 575
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 576 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 635
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 636 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 263 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 322
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 323 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 373
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 374 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 434 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 492
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 493 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 552
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 375 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 434
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 435 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 485
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 486 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 545
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 546 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 604
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 605 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 664
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 665 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 724
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 725 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 186 bits (472), Expect = 5e-47
Identities = 119/393 (30%), Positives = 209/393 (53%), Gaps = 33/393 (8%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP---------STQT 280
Y+ + + C +FL+A ++ + L MK S+ + L++ S ++
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435
Query: 281 TQYLRADTP--NNATPITSSLGYPTLR-IEKNDLRSVTLLEAKGKVKDIAISRERITLKD 337
+ + ++TP T ++S+ P L + + +L E R+++TL
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE---------FPRDKLTLGK 486
Query: 338 VLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHR 394
L EG FG++ + ID+ P + VK +KD A+E ++ +++E ++ + H+
Sbjct: 487 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546
Query: 395 NLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLV 446
N++ + C ++G VI+ Y + GNL+ +LR + + + ++ +DLV
Sbjct: 547 NIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605
Query: 447 HMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNEN 506
Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665
Query: 507 RPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 566
PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725
Query: 567 PINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 181 bits (458), Expect = 2e-45
Identities = 132/398 (33%), Positives = 203/398 (51%), Gaps = 29/398 (7%)
Query: 218 VHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLS-QP 276
V A S +S GV + LV + + L S + L S L Q
Sbjct: 366 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 425
Query: 277 STQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLK 336
S ++ + ++TP SS PTL +V+ LE K +SR R+TL
Sbjct: 426 SLESNASMSSNTPLVRIARLSSGEGPTLA-------NVSELELPADPK-WELSRARLTLG 477
Query: 337 DVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HH 393
L EG FG++ I ID+ K VK +KD A++ ++ +++E ++ + H
Sbjct: 478 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 537
Query: 394 RNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ------------CKLVEANNPQAIS 441
+N++ + C + G V++ Y GNL+ FLR CK E + ++
Sbjct: 538 KNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPE----EQLT 592
Query: 442 QQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 501
+DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 593 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 652
Query: 502 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG 561
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY I E+ LK+G
Sbjct: 653 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 712
Query: 562 YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+R+ +P NC +L+ +M CW P +RP F+QLV+ L
Sbjct: 713 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 181 bits (458), Expect = 2e-45
Identities = 123/370 (33%), Positives = 197/370 (53%), Gaps = 38/370 (10%)
Query: 251 HLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLGYPTLRI---- 306
H+ +K +E++ S + T L+ +NA+ +++ P +RI
Sbjct: 284 HIQWLKHVEVNGS--------KVGPDGTPYVTVLKVSLESNASMSSNT---PLVRIARLS 332
Query: 307 --EKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIF--HGILIDEKDPNKEK 362
E L +V+ LE K +SR R+TL L EG FG++ I ID+ K
Sbjct: 333 SGEGPTLANVSELELPADPK-WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 391
Query: 363 QAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGN 421
VK +KD A++ ++ +++E ++ + H+N++ + C + G V++ Y GN
Sbjct: 392 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-YVLVEYAAKGN 450
Query: 422 LKLFLRQ------------CKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDL 469
L+ FLR CK E + ++ +DLV A Q+A GM YLA ++ IH+DL
Sbjct: 451 LREFLRARRPPGLDYSFDTCKPPE----EQLTFKDLVSCAYQVARGMEYLASQKCIHRDL 506
Query: 470 AARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVW 529
AARN ++ + +KI D L+RD+ +DY+ N PV+WMA E+L + ++ SDVW
Sbjct: 507 AARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 566
Query: 530 AFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEER 589
+FGV LWE+ TLG +PY I E+ LK+G+R+ +P NC +L+ +M CW P +R
Sbjct: 567 SFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQR 626
Query: 590 PKFQQLVQCL 599
P F+QLV+ L
Sbjct: 627 PTFKQLVEDL 636
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 181 bits (458), Expect = 2e-45
Identities = 132/398 (33%), Positives = 203/398 (51%), Gaps = 29/398 (7%)
Query: 218 VHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLS-QP 276
V A S +S GV + LV + + L S + L S L Q
Sbjct: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 423
Query: 277 STQTTQYLRADTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLK 336
S ++ + ++TP SS PTL +V+ LE K +SR R+TL
Sbjct: 424 SLESNASMSSNTPLVRIARLSSGEGPTLA-------NVSELELPADPK-WELSRARLTLG 475
Query: 337 DVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HH 393
L EG FG++ I ID+ K VK +KD A++ ++ +++E ++ + H
Sbjct: 476 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 535
Query: 394 RNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ------------CKLVEANNPQAIS 441
+N++ + C + G V++ Y GNL+ FLR CK E + ++
Sbjct: 536 KNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPE----EQLT 590
Query: 442 QQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 501
+DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 591 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 650
Query: 502 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG 561
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY I E+ LK+G
Sbjct: 651 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 710
Query: 562 YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
+R+ +P NC +L+ +M CW P +RP F+QLV+ L
Sbjct: 711 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 180 bits (457), Expect = 3e-45
Identities = 113/387 (29%), Positives = 187/387 (48%), Gaps = 8/387 (2%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTP 289
Y V + V F + ++L +L L + + S S+ + P + +
Sbjct: 434 YAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSS 493
Query: 290 NNATPITSSLGYPTLRIEKN-DLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIF 348
+ P +G + + +N +T + K I R I LK L EG FG++F
Sbjct: 494 SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVF 553
Query: 349 HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE 408
+ + VKT+KD AS+ E+ L L H +++ VC+E G+
Sbjct: 554 LAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVE-GD 611
Query: 409 KPMVILPYMNWGNLKLFLRQ-----CKLVEANNPQAISQQDLVHMAIQIACGMSYLARRE 463
+++ YM G+L FLR + E N P ++Q ++H+A QIA GM YLA +
Sbjct: 612 PLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH 671
Query: 464 VIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFS 523
+H+DLA RNC++ + L VKI D +SRD++ DY+ +G + P+RWM ES++ +F+
Sbjct: 672 FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT 731
Query: 524 SASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWA 583
+ SDVW+ GV LWE+ T G+ P+ + E+ + G + +P CP E++ +M CW
Sbjct: 732 TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQ 791
Query: 584 LDPEERPKFQQLVQCLTEFHAALGAYV 610
+P R + + L A Y+
Sbjct: 792 REPHMRKNIKGIHTLLQNLAKASPVYL 818
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 179 bits (454), Expect = 7e-45
Identities = 100/281 (35%), Positives = 166/281 (59%), Gaps = 12/281 (4%)
Query: 330 RERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 387
R+++TL L EG FG++ + ID+ P + VK +KD A+E ++ +++E
Sbjct: 362 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 421
Query: 388 LRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQ 438
++ + H+N++ + C ++G VI+ Y + GNL+ +LR + + +
Sbjct: 422 MKMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480
Query: 439 AISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDY 498
++ +DLV Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY
Sbjct: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540
Query: 499 HCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYL 558
+ N PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ L
Sbjct: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600
Query: 559 KDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 599
K+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 641
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 177 bits (449), Expect = 3e-44
Identities = 100/282 (35%), Positives = 158/282 (56%), Gaps = 8/282 (2%)
Query: 327 AISRERITLKDVLQEGTFGRIFHGILIDEKDPNK-EKQAFVKTVKDQASEIQVTMMLTES 385
A RE++TL+ +L G FG ++ G +D E + VKT+K +++ + L E+
Sbjct: 1939 AFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 1998
Query: 386 CKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDL 445
+ +H N+L VC+ E +IL M G+L +LR+ ++ P ++ DL
Sbjct: 1999 HLMSKFNHPNILKQLGVCLLN-EPQYIILELMEGGDLLTYLRKARMATFYGP-LLTLVDL 2056
Query: 446 VHMAIQIACGMSYLARREVIHKDLAARNCVID-----DTLQVKITDNALSRDLFPMDYHC 500
V + + I+ G YL R IH+DLAARNC++ VKI D L+RD++ DY+
Sbjct: 2057 VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYR 2116
Query: 501 LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKD 560
PVRWMA ESL++ F++ SDVW+FG+ +WE++TLG PY ++ Y++
Sbjct: 2117 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 2176
Query: 561 GYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 602
G R+ P NCPD+L+ +M CWA +P++RP F ++ L F
Sbjct: 2177 GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,336,639
Number of Sequences: 37866
Number of extensions: 1131751
Number of successful extensions: 10400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 447
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 8029
Number of HSP's gapped (non-prelim): 2015
length of query: 610
length of database: 18,247,518
effective HSP length: 108
effective length of query: 502
effective length of database: 14,157,990
effective search space: 7107310980
effective search space used: 7107310980
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.