Search of human proteins with 5453870

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453870 platelet-derived growth factor receptor alpha
precursor [Homo sapiens]
         (1089 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453870 platelet-derived growth factor receptor alpha precurs...  2181   0.0  
gi|4505683 platelet-derived growth factor receptor beta precurso...   885   0.0  
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   536   e-152
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   534   e-151
gi|27262659 colony stimulating factor 1 receptor precursor [Homo...   492   e-139
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]             423   e-118
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   377   e-104
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    366   e-101
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [...   357   3e-98
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [...   357   3e-98
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               197   3e-50
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               197   3e-50
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   197   6e-50
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   197   6e-50
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   197   6e-50
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   197   6e-50
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   194   5e-49
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   194   5e-49
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   194   5e-49
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   194   5e-49
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   194   5e-49
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   194   5e-49
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   194   5e-49
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   194   5e-49
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   194   5e-49
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   193   6e-49
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   193   6e-49
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   193   6e-49
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   187   5e-47
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   187   5e-47

>gi|5453870 platelet-derived growth factor receptor alpha precursor
            [Homo sapiens]
          Length = 1089

 Score = 2181 bits (5652), Expect = 0.0
 Identities = 1089/1089 (100%), Positives = 1089/1089 (100%)

Query: 1    MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 60
            MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
Sbjct: 1    MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 60

Query: 61   MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 120
            MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
Sbjct: 61   MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 120

Query: 121  VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 180
            VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
Sbjct: 121  VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 180

Query: 181  TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 240
            TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
Sbjct: 181  TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 240

Query: 241  EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 300
            EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
Sbjct: 241  EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 300

Query: 301  EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 360
            EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
Sbjct: 301  EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 360

Query: 361  TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 420
            TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
Sbjct: 361  TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 420

Query: 421  VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 480
            VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
Sbjct: 421  VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 480

Query: 481  RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 540
            RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
Sbjct: 481  RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 540

Query: 541  SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 600
            SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
Sbjct: 541  SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 600

Query: 601  SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660
            SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
Sbjct: 601  SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660

Query: 661  LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 720
            LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
Sbjct: 661  LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 720

Query: 721  VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 780
            VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
Sbjct: 721  VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 780

Query: 781  LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 840
            LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
Sbjct: 781  LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 840

Query: 841  RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 900
            RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
Sbjct: 841  RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 900

Query: 901  VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 960
            VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
Sbjct: 901  VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 960

Query: 961  SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII 1020
            SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
Sbjct: 961  SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII 1020

Query: 1021 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS 1080
            PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
Sbjct: 1021 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS 1080

Query: 1081 SDLVEDSFL 1089
            SDLVEDSFL
Sbjct: 1081 SDLVEDSFL 1089


>gi|4505683 platelet-derived growth factor receptor beta precursor
            [Homo sapiens]
          Length = 1106

 Score =  885 bits (2286), Expect = 0.0
 Identities = 488/1084 (45%), Positives = 673/1084 (62%), Gaps = 65/1084 (5%)

Query: 6    PAFLVLGCLLTGLSLILCQLSLPS---ILPNENEKVVQLNSSFSLRCFGESEVSWQYPMS 62
            PA  + G LL    L+L +  +     + P   E V+ ++S+F L C G + V W+  MS
Sbjct: 8    PALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWER-MS 66

Query: 63   EEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVP 122
            +E   ++     +   G F +VL +++ +   TG Y C +N ++  E + E + +YI+VP
Sbjct: 67   QEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ERKRLYIFVP 121

Query: 123  DPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASYDSRQGFNG 180
            DP V F+P    +  + + +     IPCR TDP+  VTLH  +G V  P  YD ++GF+G
Sbjct: 122  DPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSG 181

Query: 181  TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 240
             F    YIC+ T+  ++  +  + VY L+ +S +++ + A++TV + GE I + C V  N
Sbjct: 182  IFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENITLMCIVIGN 240

Query: 241  EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVY----TLTVPEATVKDSGDYECAARQAT 296
            EVV+ +WTYP +  G+   ++E +    + + Y     L +P A ++DSG Y C   ++ 
Sbjct: 241  EVVNFEWTYPRKESGR---LVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESV 297

Query: 297  REVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTL 356
             + ++ K + I+V E G++ +      L+   LH  +   V   AYPPP + W K+N TL
Sbjct: 298  NDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTL 357

Query: 357  IENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPS 415
             ++   EI      + E RY S+L L+R K  ++GHYT+ A +EDA    +F+L   VP 
Sbjct: 358  GDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPV 417

Query: 416  SILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN------V 469
             +L+L + H  S G QTVRC   G P P+I W  C+D+K+C  E   T+L N+      +
Sbjct: 418  RVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQL 476

Query: 470  SNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAA 529
               +T         V   +    V+  ++VRC  +N +G + +E+ +V  +L  ++ V +
Sbjct: 477  ETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVIS 536

Query: 530  AVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFP 589
            A+L L+V+ IISLI+L+++W++KPRYEIRW+VIES+S DGHEYIYVDPMQLPYDS WE P
Sbjct: 537  AILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELP 596

Query: 590  RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 649
            RD LVLGR LGSGAFG+VVE TA+GLS SQ  MKVAVKMLK TARSSEKQALMSELKIM+
Sbjct: 597  RDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMS 656

Query: 650  HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELD 706
            HLGPHLN+VNLLGACTK GPIYIITEYC YGDLV+YLH+N+ +FL HH +K   P  EL 
Sbjct: 657  HLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELY 716

Query: 707  IFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPA 766
               L P      S+V L+ E++G YMDM + ++  YVPML+ K   KY+DI+ S Y  P 
Sbjct: 717  SNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPY 775

Query: 767  SYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 826
                 S  +   +  L ++ S  L+ +DL+ F+YQVA GMEFLASKNCVHRDLAARNVL+
Sbjct: 776  DNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLI 834

Query: 827  AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLW 886
             +GK+VKICDFGLARDIM DSNY+SKGSTFLP+KWMAPESIF++LYTTLSDVWS+GILLW
Sbjct: 835  CEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLW 894

Query: 887  EIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHL 946
            EIF+LGGTPYP + ++  FYN IK GYRMA+P HA+ E+YEIM KCW  + E RP F  L
Sbjct: 895  EIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQL 954

Query: 947  SEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMR------------VDSDNAYIGVTYK 994
              ++E LL   YKK Y+++  +FL+SDHPA+ R +            +D+ +        
Sbjct: 955  VLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQP 1014

Query: 995  NEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGS 1054
            NE                  D+ YIIPLP  DP PE  D G      S  S  S +   +
Sbjct: 1015 NE-----------------GDNDYIIPLP--DPKPEVADEGPLEGSPSLAS--STLNEVN 1053

Query: 1055 SSST 1058
            +SST
Sbjct: 1054 TSST 1057


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  536 bits (1381), Expect = e-152
 Identities = 352/965 (36%), Positives = 504/965 (52%), Gaps = 89/965 (9%)

Query: 26  SLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVL 85
           S PSI P +++ +V++     L C     V W + + +E +        EN    ++T  
Sbjct: 35  SPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETN--------ENKQNEWIT-- 84

Query: 86  EVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDS 145
               A A +TG YTC   H  +         IY++V DP   F    + D  +  ++D+ 
Sbjct: 85  --EKAEATNTGKYTCTNKHGLSNS-------IYVFVRDPAKLF----LVDRSLYGKEDND 131

Query: 146 AIIPCRTTDPE-TPVTLHNSEGV-VPASY----DSRQGFNGTFTVGPYI-----CEATVK 194
            ++ C  TDPE T  +L   +G  +P       D + G         Y      C    +
Sbjct: 132 TLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQE 191

Query: 195 GKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFN-NEVVDLQWTYPGE 252
           GK   +  F +    A   + +  +     + + GE   VTC + + +  V   W     
Sbjct: 192 GKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWK---- 247

Query: 253 VKGKGITMLEEIKVPS-------IKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
            +    T L+E K  S        +   TLT+  A V DSG + C A             
Sbjct: 248 -RENSQTKLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVT--T 303

Query: 306 TISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRIS-WLKNNLTLIENLTEIT 364
           T+ V +KGFI I P  +    VN  E    +VE  A+P P    W+  N T  +   +  
Sbjct: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363

Query: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDH 424
              E    IRY S+L L R K  + G YT +  N D   +  F +       IL      
Sbjct: 364 KS-ENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLV 422

Query: 425 HGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTV 484
           +G      ++C A G P P I+W  C   ++     S ++L  +V  + +      +  V
Sbjct: 423 NGM-----LQCVAAGFPEPTIDWYFCPGTEQ---RCSASVLPVDVQTLNSSGPPFGKLVV 474

Query: 485 EGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIV--IISL 542
           +  +  +  +    V C A N +G  +              T+   +L+  VIV  ++ +
Sbjct: 475 QSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCI 534

Query: 543 IVLVVIWK--QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 600
           IV+++ +K  QKP YE++W+V+E I+  G+ Y+Y+DP QLPYD +WEFPR+ L  G+ LG
Sbjct: 535 IVMILTYKYLQKPMYEVQWKVVEEIN--GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLG 592

Query: 601 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660
           +GAFGKVVE TAYGL +S   M VAVKMLKP+A  +E++ALMSELK++++LG H+NIVNL
Sbjct: 593 AGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNL 652

Query: 661 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 720
           LGACT  GP  +ITEYC YGDL+N+L + RDSF+    E   +      L  + ES+ S 
Sbjct: 653 LGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCS- 711

Query: 721 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 780
                ++  +YMDMK      YV       V   +D +RS+  R  SY     ++ +V  
Sbjct: 712 -----DSTNEYMDMKPG--VSYV-------VPTKADKRRSV--RIGSY-----IERDVTP 750

Query: 781 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 840
            + +D+   L L DLLSF+YQVA+GM FLASKNC+HRDLAARN+LL  G+I KICDFGLA
Sbjct: 751 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA 810

Query: 841 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 900
           RDI +DSNYV KG+  LPVKWMAPESIF+ +YT  SDVWSYGI LWE+FSLG +PYPGM 
Sbjct: 811 RDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP 870

Query: 901 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 960
           VDS FY  IK G+RM  P+HA +E+Y+IM  CW+++P KRP+F  + +++E  +      
Sbjct: 871 VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNH 930

Query: 961 SYEKI 965
            Y  +
Sbjct: 931 IYSNL 935


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  534 bits (1375), Expect = e-151
 Identities = 353/969 (36%), Positives = 505/969 (52%), Gaps = 93/969 (9%)

Query: 26  SLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVL 85
           S PSI P +++ +V++     L C     V W + + +E +        EN    ++T  
Sbjct: 35  SPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETN--------ENKQNEWIT-- 84

Query: 86  EVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDS 145
               A A +TG YTC   H  +         IY++V DP   F    + D  +  ++D+ 
Sbjct: 85  --EKAEATNTGKYTCTNKHGLSNS-------IYVFVRDPAKLF----LVDRSLYGKEDND 131

Query: 146 AIIPCRTTDPE-TPVTLHNSEGV-VPASY----DSRQGFNGTFTVGPYI-----CEATVK 194
            ++ C  TDPE T  +L   +G  +P       D + G         Y      C    +
Sbjct: 132 TLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQE 191

Query: 195 GKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFN-NEVVDLQWTYPGE 252
           GK   +  F +    A   + +  +     + + GE   VTC + + +  V   W     
Sbjct: 192 GKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWK---- 247

Query: 253 VKGKGITMLEEIKVPS-------IKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
            +    T L+E K  S        +   TLT+  A V DSG + C A             
Sbjct: 248 -RENSQTKLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVT--T 303

Query: 306 TISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRIS-WLKNNLTLIENLTEIT 364
           T+ V +KGFI I P  +    VN  E    +VE  A+P P    W+  N T  +   +  
Sbjct: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363

Query: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDH 424
              E    IRY S+L L R K  + G YT +  N D   +  F +       IL      
Sbjct: 364 KS-ENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLV 422

Query: 425 HGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTV 484
           +G      ++C A G P P I+W  C   ++     S ++L  +V  + +      +  V
Sbjct: 423 NGM-----LQCVAAGFPEPTIDWYFCPGTEQ---RCSASVLPVDVQTLNSSGPPFGKLVV 474

Query: 485 EGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSEL----TVAAAVLVLLVIV-- 538
           +  +  +  +    V C A N +G  +            E     T+   +L+  VIV  
Sbjct: 475 QSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAG 534

Query: 539 IISLIVLVVIWK--QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLG 596
           ++ +IV+++ +K  QKP YE++W+V+E I+  G+ Y+Y+DP QLPYD +WEFPR+ L  G
Sbjct: 535 MMCIIVMILTYKYLQKPMYEVQWKVVEEIN--GNNYVYIDPTQLPYDHKWEFPRNRLSFG 592

Query: 597 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLN 656
           + LG+GAFGKVVE TAYGL +S   M VAVKMLKP+A  +E++ALMSELK++++LG H+N
Sbjct: 593 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMN 652

Query: 657 IVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADES 716
           IVNLLGACT  GP  +ITEYC YGDL+N+L + RDSF+    E   +      L  + ES
Sbjct: 653 IVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKES 712

Query: 717 TRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDS 776
           + S      ++  +YMDMK      YV       V   +D +RS+  R  SY     ++ 
Sbjct: 713 SCS------DSTNEYMDMKPG--VSYV-------VPTKADKRRSV--RIGSY-----IER 750

Query: 777 EVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICD 836
           +V   + +D+   L L DLLSF+YQVA+GM FLASKNC+HRDLAARN+LL  G+I KICD
Sbjct: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810

Query: 837 FGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPY 896
           FGLARDI +DSNYV KG+  LPVKWMAPESIF+ +YT  SDVWSYGI LWE+FSLG +PY
Sbjct: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870

Query: 897 PGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPG 956
           PGM VDS FY  IK G+RM  P+HA +E+Y+IM  CW+++P KRP+F  + +++E  +  
Sbjct: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930

Query: 957 QYKKSYEKI 965
                Y  +
Sbjct: 931 STNHIYSNL 939


>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
           sapiens]
          Length = 972

 Score =  492 bits (1267), Expect = e-139
 Identities = 327/954 (34%), Positives = 488/954 (51%), Gaps = 91/954 (9%)

Query: 27  LPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLE 86
           +P I P+  E VV+  ++ +LRC G   V W  P S   +    + ++ ++S     +L 
Sbjct: 20  IPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWT----LYSDGSSS-----ILS 70

Query: 87  VSSASAAHTGLYTCYYNHTQTEENELEGRH--IYIYVPDPDVAFVPLGMTDYLVIVEDDD 144
            ++A+  +TG Y C      TE  +  G    I++YV DP     P  +    V+V +D 
Sbjct: 71  TNNATFQNTGTYRC------TEPGDPLGGSAAIHLYVKDPAR---PWNVLAQEVVVFEDQ 121

Query: 145 SAIIPCRTTDP--ETPVTLHNSEGVVPASYDSRQGFNGT--FTVG--------PYICEAT 192
            A++PC  TDP  E  V+L    G  P    +   F+    FT+          Y C A 
Sbjct: 122 DALLPCLLTDPVLEAGVSLVRVRGR-PLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL 180

Query: 193 VKGKKFQTIPFNVYALKAT-SELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPG 251
           + G+K  +I   +   K       L +   + V   GE   + C+  + +V    +    
Sbjct: 181 MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN 240

Query: 252 EVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHE 311
             K   I    +      + V TL + +   + +G+Y C A     + K    +   V E
Sbjct: 241 NTK-LAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNV--QGKHSTSMFFRVVE 297

Query: 312 KGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPR-ISWLKNNLTLIENLTEITTDVEKI 370
             ++ +    + ++ V + E  +  V V AYP  +  +W                +    
Sbjct: 298 SAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTK 357

Query: 371 QEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGG 430
              R+   L L R K  ++G Y+ +A+N    ++ TFEL  + P  +  +    +GS   
Sbjct: 358 DTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSG-- 415

Query: 431 QTVRCTAEGTPLPDIEWMICKD-IKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVT 489
            T+ C A G P P++ W+ C     +C+      +  +    ++++     + TV+  +T
Sbjct: 416 -TLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQ-EPFHKVTVQSLLT 473

Query: 490 FAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSE-------LTVAAAVLVLLVIVIISL 542
              +E      C A N +G+ +     ++    +          V  A + ++ ++++ L
Sbjct: 474 VETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLL 533

Query: 543 IVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSG 602
           ++L+  +KQKP+Y++RW++IES   +G+ Y ++DP QLPY+ +WEFPR+ L  G+ LG+G
Sbjct: 534 LLLLYKYKQKPKYQVRWKIIESY--EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAG 591

Query: 603 AFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLG 662
           AFGKVVE TA+GL +   V+KVAVKMLK TA + EK+ALMSELKIM+HLG H NIVNLLG
Sbjct: 592 AFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLG 651

Query: 663 ACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVI 722
           ACT  GP+ +ITEYC YGDL+N+L +  ++ L               L+P  +       
Sbjct: 652 ACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGP------------SLSPGQDP------ 693

Query: 723 LSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYD-----RPASYKKKSMLDSE 777
              E   DY ++           LE+K V + S       D     RP S    S  DS 
Sbjct: 694 ---EGGVDYKNIH----------LEKKYVRRDSGFSSQGVDTYVEMRPVS---TSSNDSF 737

Query: 778 VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDF 837
            +  L  ++   L L DLL F+ QVA+GM FLASKNC+HRD+AARNVLL  G + KI DF
Sbjct: 738 SEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDF 797

Query: 838 GLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYP 897
           GLARDIM+DSNY+ KG+  LPVKWMAPESIFD +YT  SDVWSYGILLWEIFSLG  PYP
Sbjct: 798 GLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 857

Query: 898 GMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVE 951
           G++V+S FY  +K GY+MA+P  A   +Y IM  CW  EP  RP+F  +   ++
Sbjct: 858 GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 911


>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
          Length = 993

 Score =  423 bits (1088), Expect = e-118
 Identities = 273/755 (36%), Positives = 398/755 (52%), Gaps = 74/755 (9%)

Query: 226 KSGETIVVTC-AVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPS-----IKLVYTLTVPE 279
           K GE + + C AV  N    L W    +   +G     E+   S     I++++   V  
Sbjct: 263 KVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYF--EMSTYSTNRTMIRILFAF-VSS 319

Query: 280 ATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV 339
               D+G Y C++ +   +        +++ EKGFI    +    E ++ +E   F V  
Sbjct: 320 VARNDTGYYTCSSSKHPSQ-----SALVTIVEKGFINATNSSEDYE-IDQYEEFCFSVRF 373

Query: 340 RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNE 399
           +AYP  R +W           +  +   E+       S  K    K +  G Y   A+N+
Sbjct: 374 KAYPQIRCTW---------TFSRKSFPCEQKGLDNGYSISKFCNHKHQP-GEYIFHAEND 423

Query: 400 DAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIK-KCNN 458
           DA  +  F L  +    +L                C ++G PLP   W  C D    C  
Sbjct: 424 DAQFTKMFTLNIRRKPQVL-------AEASASQASCFSDGYPLPSWTWKKCSDKSPNCTE 476

Query: 459 ETS---WTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK 515
           E +   W   AN       ++  +  S+    +  ++  +   V+C A N LG     + 
Sbjct: 477 EITEGVWNRKANR------KVFGQWVSS--STLNMSEAIKGFLVKCCAYNSLGTSCETIL 528

Query: 516 LVAPT----LRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHE 571
           L +P     ++  ++  A + V L+ +++  +++   +K++ RYE + ++++      +E
Sbjct: 529 LNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNE 588

Query: 572 YIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP 631
           Y YVD  +  YD +WEFPR+ L  G+VLGSGAFGKV+  TAYG+S++   ++VAVKMLK 
Sbjct: 589 YFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKE 648

Query: 632 TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRD 691
            A SSE++ALMSELK+MT LG H NIVNLLGACT SGPIY+I EYC YGDL+NYL   R+
Sbjct: 649 KADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRE 708

Query: 692 SFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEV 751
            F                        R++  +  E+N  +    Q+     +P     ++
Sbjct: 709 KF-----------------------HRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQI 745

Query: 752 SKYSDIQRSLYDRPASYKKKSMLDSE-VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLA 810
              SD    L+    S+  +  ++ E  K L  +++   LT  DLL F YQVA+GMEFL 
Sbjct: 746 HPDSDQISGLHGN--SFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLE 803

Query: 811 SKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDN 870
            K+CVHRDLAARNVL+  GK+VKICDFGLARDIM DSNYV +G+  LPVKWMAPES+F+ 
Sbjct: 804 FKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEG 863

Query: 871 LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMV 930
           +YT  SDVWSYGILLWEIFSLG  PYPG+ VD+ FY  I++G++M +P +AT E+Y IM 
Sbjct: 864 IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQ 923

Query: 931 KCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965
            CW  +  KRPSF +L+  +   L    +  Y+ +
Sbjct: 924 SCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNV 958



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 26/132 (19%), Positives = 52/132 (39%), Gaps = 23/132 (17%)

Query: 381 LIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHH--GSTGGQTVRCTAE 438
           +++  E  +G Y +  Q+E    +YT      + +++L  +   +         + C +E
Sbjct: 130 ILKMTETQAGEYLLFIQSE--ATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISE 187

Query: 439 GTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIA 498
             P P +EW++C    +   E S  ++      ++ E+   D                  
Sbjct: 188 SVPEPIVEWVLCDSQGESCKEESPAVVKKE-EKVLHELFGTD------------------ 228

Query: 499 VRCLAKNLLGAE 510
           +RC A+N LG E
Sbjct: 229 IRCCARNELGRE 240


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  377 bits (967), Expect = e-104
 Identities = 305/1006 (30%), Positives = 473/1006 (47%), Gaps = 145/1006 (14%)

Query: 19   SLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNS 78
            ++I  Q+S P  +       + LN + +       +++W YP  + + + V  R +++NS
Sbjct: 228  TIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNS 287

Query: 79   --GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDY 136
               +F +VL +        GLYTC      + ++     HIY      D AF+ +     
Sbjct: 288  HANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQ 341

Query: 137  LVI--VEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSR---QGFN-----------G 180
             V+  V    S  +  +     +P  +   +G+      +R   +G++           G
Sbjct: 342  QVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAG 401

Query: 181  TFTVGPYICEATVKGKKFQTIPFNV----YALKATSELDLEMEALKTVYKSGETIVVTCA 236
             +T+   I ++ V      T+  NV    Y    +S  D        +Y  G   ++TC 
Sbjct: 402  NYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD------PALYPLGSRQILTCT 455

Query: 237  VFNNEVVDLQWTYP------GEVKGKGITMLEEI-----------KVPSI---------- 269
             +      ++W +        E +    +  EE            ++ SI          
Sbjct: 456  AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515

Query: 270  -KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAV 327
             K+  TL V ++ +  SG Y C A      V       I+    GF + ++   ++ E +
Sbjct: 516  NKMASTLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL 573

Query: 328  NLHEVKHFVVEVRAYPPPRISWLK----NNLTLIENLTEITTDVEKIQEIRYRSKLKLIR 383
             L         V  +    ++W+     NN T+  ++++    + K   I     L ++ 
Sbjct: 574  KLS------CTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN--LTIMN 625

Query: 384  AKEEDSGHYTIVAQN----EDAVKSYTFELLTQVPSSILDLVDDHHGS-TGGQTVRCTAE 438
               +DSG Y   A+N    E+ ++     +  Q    +L  + DH  + +   T+ C A 
Sbjct: 626  VSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHAN 685

Query: 439  GTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIA 498
            G P P I W   K+  K   E    +   + +  I  +   D      + T  K     +
Sbjct: 686  GVPEPQITWF--KNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESS 743

Query: 499  VRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIR 558
                 +      N EL  +  T      VAA +  LL+ + I  +       ++   EI+
Sbjct: 744  AYLTVQGTSDKSNLELITLTCTC-----VAATLFWLLLTLFIRKM-------KRSSSEIK 791

Query: 559  WRVIESISPDGHEYIYVDPMQLPYD-SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSR 617
               +  I       +     +LPYD S+WEF R+ L LG+ LG GAFGKVV+ +A+G+ +
Sbjct: 792  TDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKK 851

Query: 618  SQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSG-PIYIITEY 676
            S     VAVKMLK  A +SE +ALM+ELKI+TH+G HLN+VNLLGACTK G P+ +I EY
Sbjct: 852  SPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEY 911

Query: 677  CFYGDLVNYLHKNRDSF-------LSHHPEKPKKELDIF-GLNPADESTRSYVILSFENN 728
            C YG+L NYL   RD F       L   P+K K E  +  G  P  +S  S    SF ++
Sbjct: 912  CKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSE--SFASS 969

Query: 729  GDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE 788
            G   D   +D       +E +E            D    YK                  E
Sbjct: 970  GFQEDKSLSD-------VEEEE------------DSDGFYK------------------E 992

Query: 789  GLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSN 848
             +T+ DL+S+++QVARGMEFL+S+ C+HRDLAARN+LL++  +VKICDFGLARDI  + +
Sbjct: 993  PITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPD 1052

Query: 849  YVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNK 908
            YV KG T LP+KWMAPESIFD +Y+T SDVWSYG+LLWEIFSLGG+PYPG+ +D  F ++
Sbjct: 1053 YVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSR 1112

Query: 909  IKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            ++ G RM  P+++T E+Y+IM+ CW+ +P++RP F  L E + +LL
Sbjct: 1113 LREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158



 Score =  147 bits (370), Expect = 7e-35
 Identities = 155/557 (27%), Positives = 242/557 (43%), Gaps = 74/557 (13%)

Query: 10  VLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP-MSEEESSD 68
           +L CLL   S    +L  P +     + ++Q   +  L+C GE+   W  P M  +ES  
Sbjct: 14  LLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESER 73

Query: 69  VEIRNEE--NNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDV 126
           + I       N   F + L +++A A HTG Y+C Y    T + +     IYI++ D   
Sbjct: 74  LSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGR 133

Query: 127 AFVPL-GMTDYLVIVEDDDSAIIPCRTTDPETPVTLHN--SEGVVPAS----YDSRQGF- 178
            FV +      ++ + +    +IPCR T P   VTL     + ++P      +DSR+GF 
Sbjct: 134 PFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI 193

Query: 179 --NGTF-TVGPYICEATVKGKKFQTIPFNVYALKATSE-LDLEMEALKTV-YKSGETIVV 233
             N T+  +G   CEATV G  ++T   N    + T+  +D+++   + V    G T+V+
Sbjct: 194 ISNATYKEIGLLTCEATVNGHLYKT---NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL 250

Query: 234 TCAVFN--NEVVDLQWTYPGEVKGKGITMLEEIKVPS--IKLVYT-LTVPEATVKDSGDY 288
            C      N  V + W+YP E K K  ++   I   +    + Y+ LT+ +   KD G Y
Sbjct: 251 NCTATTPLNTRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLY 309

Query: 289 ECAARQATREVKEMKKVTISVH--EKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPP 345
            C  R         K V  SVH  +K FI +K    Q LE V         ++V+A+P P
Sbjct: 310 TCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSP 365

Query: 346 RISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIR-AKEEDSGHYTIV--AQNEDAV 402
            + WLK+ L   E      T          R    +I+   EED+G+YTI+   +  +  
Sbjct: 366 EVVWLKDGLPATEKSARYLT----------RGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415

Query: 403 KSYTFELLTQVPSSILDLVDDH------HGSTGGQTVRCTAEGTPLPDIEWM--ICK--- 451
           K+ T  L+  V   I +           +     Q + CTA G P P I+W    C    
Sbjct: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475

Query: 452 DIKKC----NNETSWTILA-NNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVR------ 500
              +C    NNE S+ + A +N+ N I  I  R  + +EG+    K+  T+ V       
Sbjct: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQR-MAIIEGK---NKMASTLVVADSRISG 531

Query: 501 ---CLAKNLLGAENREL 514
              C+A N +G   R +
Sbjct: 532 IYICIASNKVGTVGRNI 548


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  366 bits (939), Expect = e-101
 Identities = 293/992 (29%), Positives = 444/992 (44%), Gaps = 175/992 (17%)

Query: 54   EVSWQYPMSEEESSDVEIRNEENNSGL----FVTVLEVSSASAAHTGLYTCYYNH-TQTE 108
            + +W+YP S+ +   +  R+ +  SG     F++ L +   + +  GLYTC  +    T+
Sbjct: 257  DFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTK 316

Query: 109  ENELEGRHIYIYVPDPDVAFVPLGM-TDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV 167
            +N         +V   +  FV  G   + LV     +   IP +      P       G+
Sbjct: 317  KNST-------FVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGI 369

Query: 168  -VPASYDSRQGF-----------NGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD 215
             + +++  + G             G +TV   +     K K+   +   VY      E  
Sbjct: 370  PLESNHTIKAGHVLTIMEVSERDTGNYTV--ILTNPISKEKQSHVVSLVVYVPPQIGEKS 427

Query: 216  LEMEALKTVYKSGETIVVTCAVFNNEVVD-LQWTYPGEVKGKGITMLEEIKVPSIKLVYT 274
            L        Y+ G T  +TC V+       + W +           LEE           
Sbjct: 428  LISPV--DSYQYGTTQTLTCTVYAIPPPHHIHWYW----------QLEE---------EC 466

Query: 275  LTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIK-PTFSQL--------- 324
               P   V  +  Y C   ++  + +   K+ ++ ++   IE K  T S L         
Sbjct: 467  ANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSA 526

Query: 325  ----EAVNLHEVKHFVVEVRAYPPPRIS---------------WLKNNLTLIENLT---- 361
                EAVN       V+       P I+               W   + +  ENLT    
Sbjct: 527  LYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKL 586

Query: 362  ----------EITTDVEKIQEIRYRSK-------------LKLIRAKEEDSGHYTIVAQN 398
                      E+ T V K  +  ++               ++L  A  +D G Y  +AQ+
Sbjct: 587  GPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQD 646

Query: 399  EDAVKSYT----FELLTQVPSSILDLVDDHHGSTGGQT-VRCTAEGTPLPDIEWMICKDI 453
                K +       +L +V  +I   +++   S G    V CTA G P P I W   KD 
Sbjct: 647  RKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWF--KDN 704

Query: 454  KKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRE 513
            +    ++   +   N +  I  +   D    EG  T           C A ++LG    E
Sbjct: 705  ETLVEDSGIVLKDGNRNLTIRRVRKED----EGLYT-----------CQACSVLGCAKVE 749

Query: 514  LKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYI 573
               +    + +  +   +LV   ++ +   +L+VI  +  +     R        G+  I
Sbjct: 750  AFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVK-----RANGGELKTGYLSI 804

Query: 574  YVDPMQLPYD----------SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 623
             +DP +LP D          S+WEFPRD L LG+ LG GAFG+V+E  A+G+ ++     
Sbjct: 805  VMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT 864

Query: 624  VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK-SGPIYIITEYCFYGDL 682
            VAVKMLK  A  SE +ALMSELKI+ H+G HLN+VNLLGACTK  GP+ +I E+C +G+L
Sbjct: 865  VAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNL 924

Query: 683  VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQY 742
              YL   R+ F+ +  +  +                      F    DY+     D  + 
Sbjct: 925  STYLRSKRNEFVPYKTKGAR----------------------FRQGKDYVGAIPVDLKRR 962

Query: 743  VPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV 802
            +  +   + S  S             ++KS+ D E +    D   + LTL  L+ +++QV
Sbjct: 963  LDSITSSQSSASSGF----------VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQV 1012

Query: 803  ARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWM 862
            A+GMEFLAS+ C+HRDLAARN+LL++  +VKICDFGLARDI  D +YV KG   LP+KWM
Sbjct: 1013 AKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWM 1072

Query: 863  APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHAT 922
            APE+IFD +YT  SDVWS+G+LLWEIFSLG +PYPG+ +D  F  ++K G RM  PD+ T
Sbjct: 1073 APETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT 1132

Query: 923  SEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             E+Y+ M+ CW+ EP +RP+F  L E + NLL
Sbjct: 1133 PEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164



 Score =  128 bits (322), Expect = 3e-29
 Identities = 118/480 (24%), Positives = 198/480 (41%), Gaps = 66/480 (13%)

Query: 25  LSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTV 84
           L LP +   ++   ++ N++  + C G+ ++ W +P + +  S+  +   E + GLF   
Sbjct: 29  LDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP-NNQSGSEQRVEVTECSDGLFCKT 87

Query: 85  LEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDD 144
           L +       TG Y C+Y  T           IY+YV D    F+      + V+   ++
Sbjct: 88  LTIPKVIGNDTGAYKCFYRETDLASV------IYVYVQDYRSPFIASVSDQHGVVYITEN 141

Query: 145 ---SAIIPCRTTDPETPVTL---HNSEGVVP----ASYDSRQGFN-GTFTV---GPYICE 190
              + +IPC  +     V+L   +  +  VP     S+DS++GF   ++ +   G   CE
Sbjct: 142 KNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCE 201

Query: 191 ATVKGKKFQTIPF-------NVYALKATSELDLEMEALKTVYKSGETIVVTCAVFN--NE 241
           A +  + +Q+I +        +Y +  +    +E+         GE +V+ C      N 
Sbjct: 202 AKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSV-------GEKLVLNCTARTELNV 254

Query: 242 VVDLQWTYPGEVKGKGITMLEEIKVPS----IKLVYTLTVPEATVKDSGDYECAARQATR 297
            +D  W YP         +  ++K  S     K + TLT+   T  D G Y CAA     
Sbjct: 255 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLM 314

Query: 298 EVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLI 357
             K      + VHEK F+        L    + E      +   YPPP I W KN + L 
Sbjct: 315 TKKN--STFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLE 372

Query: 358 ENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQN--EDAVKSYTFELLTQVP- 414
            N T           I+    L ++   E D+G+YT++  N      +S+   L+  VP 
Sbjct: 373 SNHT-----------IKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPP 421

Query: 415 ----SSILDLVDDH-HGSTGGQTVRCTAEGTPLP-DIEWMICKDIKKCNNETSWTILANN 468
                S++  VD + +G+T  QT+ CT    P P  I W    + ++C NE S  +   N
Sbjct: 422 QIGEKSLISPVDSYQYGTT--QTLTCTVYAIPPPHHIHWYWQLE-EECANEPSQAVSVTN 478


>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
            sapiens]
          Length = 1363

 Score =  357 bits (916), Expect = 3e-98
 Identities = 241/726 (33%), Positives = 361/726 (49%), Gaps = 87/726 (11%)

Query: 270  KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAVN 328
            K V  L +  A V  S  Y+C       + + +    ++    GF IE KP+   LE   
Sbjct: 516  KTVSKLVIQNANV--SAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEG-- 571

Query: 329  LHEVKHFVVEVRAYPPPRISWLKNNLTLIENL----------------TEITTDVEKIQE 372
              +      +  +Y    + W + NL+ + +                 T +   +E++  
Sbjct: 572  --QPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAP 629

Query: 373  IRYRSKLKLI--RAKEEDSGHYTIVAQN-----EDAVKSYTFELLTQVPSSILDLVDDHH 425
                + L L   R   E  GHY    Q+     +   K Y      + P    +L D   
Sbjct: 630  GARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLV 689

Query: 426  GSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVE 485
              +    ++C   G   P I W   KD +    ++   +  +N    I  +   D     
Sbjct: 690  NVSDSLEMQCLVAGAHAPSIVWY--KDERLLEEKSGVDLADSNQKLSIQRVREEDA---- 743

Query: 486  GRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLV---LLVIVIISL 542
            GR             C   N  G  N    +       + ++   +LV   ++ +    L
Sbjct: 744  GRYL-----------CSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVL 792

Query: 543  IVLVVIWKQKPRY-EIRWRVIESISPDGHEYIYVDPMQLPYD-SRWEFPRDGLVLGRVLG 600
            ++L+    ++P + +I+   +  I   G   +      L YD S+WEFPR+ L LGRVLG
Sbjct: 793  LLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLG 852

Query: 601  SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660
             GAFGKVVE +A+G+ +      VAVKMLK  A +SE +ALMSELKI+ H+G HLN+VNL
Sbjct: 853  YGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNL 912

Query: 661  LGACTK-SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRS 719
            LGACTK  GP+ +I E+C YG+L N+L   RD+F                 +P  E    
Sbjct: 913  LGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-----------------SPCAEK--- 952

Query: 720  YVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVK 779
                S E  G +  M +      +  L+R+       +  + + +     +++  D E +
Sbjct: 953  ----SPEQRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAE 1002

Query: 780  NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGL 839
            +L        LT+ DL+ +++QVARGMEFLAS+ C+HRDLAARN+LL++  +VKICDFGL
Sbjct: 1003 DLWLSP----LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGL 1058

Query: 840  ARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGM 899
            ARDI  D +YV KGS  LP+KWMAPESIFD +YTT SDVWS+G+LLWEIFSLG +PYPG+
Sbjct: 1059 ARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGV 1118

Query: 900  MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYK 959
             ++  F  +++ G RM  P+ AT  +  IM+ CW+ +P+ RP+F  L EI+ +LL G+  
Sbjct: 1119 QINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGL 1178

Query: 960  KSYEKI 965
            +  E++
Sbjct: 1179 QEEEEV 1184



 Score =  112 bits (279), Expect = 2e-24
 Identities = 113/449 (25%), Positives = 184/449 (40%), Gaps = 49/449 (10%)

Query: 28  PSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEE---------ESSDVEIRNEENNS 78
           P++   E   V+    S S+ C G+  + W +P ++E         E + V    E  ++
Sbjct: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89

Query: 79  GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLV 138
             +  VL +    A  TG Y CYY + +           Y++V D +  F+    T   +
Sbjct: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDT---L 146

Query: 139 IVEDDDSAIIPCRTTDPETPVTLHNSEGVV-----PASYDSRQGFNGTFTV---GPYI-C 189
           +V   D+  +PC  + P   VTL +   V+        +D R+G   +  +     Y+ C
Sbjct: 147 LVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQC 206

Query: 190 EATVKGKKFQTIPFNVYALKATSELDLEMEALKTV-YKSGETIVVTCAVFN--NEVVDLQ 246
           E T   + F + PF V+ +      D+++   K++    GE +V+ C V+   N  V   
Sbjct: 207 ETTWGDQDFLSNPFLVH-ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFD 265

Query: 247 WTYPGEVKGKGITMLE-EIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
           W YPG+   +G  + E   +    +L   LT+   +  D G Y C A    +  +E  +V
Sbjct: 266 WDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEV 325

Query: 306 TISVHEKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEIT 364
              VHE  FI ++      LEA    E+    V++ AYPPP   W K             
Sbjct: 326 I--VHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYK------------- 370

Query: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDA--VKSYTFELLTQVPSSILDLVD 422
            D + +        L L    E  +G YT+   N  A   ++ + EL+  VP  I +   
Sbjct: 371 -DGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEA 429

Query: 423 DH---HGSTGGQTVRCTAEGTPLP-DIEW 447
                +     Q + CTA G PLP  I+W
Sbjct: 430 SSPSIYSRHSRQALTCTAYGVPLPLSIQW 458



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 32/132 (24%), Positives = 50/132 (37%), Gaps = 9/132 (6%)

Query: 261 LEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPT 320
           LEE+   +     +L++P    +  G Y C  +      K   K  +SV       +   
Sbjct: 624 LEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQN 683

Query: 321 FSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLK 380
            + L  VN+ +       V     P I W K+     E L E  + V+         KL 
Sbjct: 684 LTDL-LVNVSDSLEMQCLVAGAHAPSIVWYKD-----ERLLEEKSGVDLADS---NQKLS 734

Query: 381 LIRAKEEDSGHY 392
           + R +EED+G Y
Sbjct: 735 IQRVREEDAGRY 746


>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
            sapiens]
          Length = 1298

 Score =  357 bits (916), Expect = 3e-98
 Identities = 241/726 (33%), Positives = 361/726 (49%), Gaps = 87/726 (11%)

Query: 270  KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAVN 328
            K V  L +  A V  S  Y+C       + + +    ++    GF IE KP+   LE   
Sbjct: 516  KTVSKLVIQNANV--SAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEG-- 571

Query: 329  LHEVKHFVVEVRAYPPPRISWLKNNLTLIENL----------------TEITTDVEKIQE 372
              +      +  +Y    + W + NL+ + +                 T +   +E++  
Sbjct: 572  --QPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAP 629

Query: 373  IRYRSKLKLI--RAKEEDSGHYTIVAQN-----EDAVKSYTFELLTQVPSSILDLVDDHH 425
                + L L   R   E  GHY    Q+     +   K Y      + P    +L D   
Sbjct: 630  GARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLV 689

Query: 426  GSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVE 485
              +    ++C   G   P I W   KD +    ++   +  +N    I  +   D     
Sbjct: 690  NVSDSLEMQCLVAGAHAPSIVWY--KDERLLEEKSGVDLADSNQKLSIQRVREEDA---- 743

Query: 486  GRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLV---LLVIVIISL 542
            GR             C   N  G  N    +       + ++   +LV   ++ +    L
Sbjct: 744  GRYL-----------CSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVL 792

Query: 543  IVLVVIWKQKPRY-EIRWRVIESISPDGHEYIYVDPMQLPYD-SRWEFPRDGLVLGRVLG 600
            ++L+    ++P + +I+   +  I   G   +      L YD S+WEFPR+ L LGRVLG
Sbjct: 793  LLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLG 852

Query: 601  SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660
             GAFGKVVE +A+G+ +      VAVKMLK  A +SE +ALMSELKI+ H+G HLN+VNL
Sbjct: 853  YGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNL 912

Query: 661  LGACTK-SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRS 719
            LGACTK  GP+ +I E+C YG+L N+L   RD+F                 +P  E    
Sbjct: 913  LGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-----------------SPCAEK--- 952

Query: 720  YVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVK 779
                S E  G +  M +      +  L+R+       +  + + +     +++  D E +
Sbjct: 953  ----SPEQRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAE 1002

Query: 780  NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGL 839
            +L        LT+ DL+ +++QVARGMEFLAS+ C+HRDLAARN+LL++  +VKICDFGL
Sbjct: 1003 DLWLSP----LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGL 1058

Query: 840  ARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGM 899
            ARDI  D +YV KGS  LP+KWMAPESIFD +YTT SDVWS+G+LLWEIFSLG +PYPG+
Sbjct: 1059 ARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGV 1118

Query: 900  MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYK 959
             ++  F  +++ G RM  P+ AT  +  IM+ CW+ +P+ RP+F  L EI+ +LL G+  
Sbjct: 1119 QINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGL 1178

Query: 960  KSYEKI 965
            +  E++
Sbjct: 1179 QEEEEV 1184



 Score =  112 bits (279), Expect = 2e-24
 Identities = 113/449 (25%), Positives = 184/449 (40%), Gaps = 49/449 (10%)

Query: 28  PSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEE---------ESSDVEIRNEENNS 78
           P++   E   V+    S S+ C G+  + W +P ++E         E + V    E  ++
Sbjct: 30  PTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDA 89

Query: 79  GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLV 138
             +  VL +    A  TG Y CYY + +           Y++V D +  F+    T   +
Sbjct: 90  RPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDT---L 146

Query: 139 IVEDDDSAIIPCRTTDPETPVTLHNSEGVV-----PASYDSRQGFNGTFTV---GPYI-C 189
           +V   D+  +PC  + P   VTL +   V+        +D R+G   +  +     Y+ C
Sbjct: 147 LVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQC 206

Query: 190 EATVKGKKFQTIPFNVYALKATSELDLEMEALKTV-YKSGETIVVTCAVFN--NEVVDLQ 246
           E T   + F + PF V+ +      D+++   K++    GE +V+ C V+   N  V   
Sbjct: 207 ETTWGDQDFLSNPFLVH-ITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFD 265

Query: 247 WTYPGEVKGKGITMLE-EIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
           W YPG+   +G  + E   +    +L   LT+   +  D G Y C A    +  +E  +V
Sbjct: 266 WDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEV 325

Query: 306 TISVHEKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEIT 364
              VHE  FI ++      LEA    E+    V++ AYPPP   W K             
Sbjct: 326 I--VHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYK------------- 370

Query: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDA--VKSYTFELLTQVPSSILDLVD 422
            D + +        L L    E  +G YT+   N  A   ++ + EL+  VP  I +   
Sbjct: 371 -DGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEA 429

Query: 423 DH---HGSTGGQTVRCTAEGTPLP-DIEW 447
                +     Q + CTA G PLP  I+W
Sbjct: 430 SSPSIYSRHSRQALTCTAYGVPLPLSIQW 458



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 32/132 (24%), Positives = 50/132 (37%), Gaps = 9/132 (6%)

Query: 261 LEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPT 320
           LEE+   +     +L++P    +  G Y C  +      K   K  +SV       +   
Sbjct: 624 LEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQN 683

Query: 321 FSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLK 380
            + L  VN+ +       V     P I W K+     E L E  + V+         KL 
Sbjct: 684 LTDL-LVNVSDSLEMQCLVAGAHAPSIVWYKD-----ERLLEEKSGVDLADS---NQKLS 734

Query: 381 LIRAKEEDSGHY 392
           + R +EED+G Y
Sbjct: 735 IQRVREEDAGRY 746


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  197 bits (502), Expect = 3e-50
 Identities = 94/212 (44%), Positives = 144/212 (67%), Gaps = 2/212 (0%)

Query: 744  PMLERKEVSKYSDIQRSLYD-RPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV 802
            P+L   E +KY  ++  L + R           S   + L   +   LT+ DL+SF +Q+
Sbjct: 799  PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQI 858

Query: 803  ARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWM 862
            ++GM++LA    VHRDLAARN+L+A+G+ +KI DFGL+RD+  + +YV +    +PVKWM
Sbjct: 859  SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 918

Query: 863  APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHAT 922
            A ES+FD++YTT SDVWS+G+LLWEI +LGG PYPG+  +  F N +K+G+RM +PD+ +
Sbjct: 919  AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCS 977

Query: 923  SEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             E+Y +M++CW  EP+KRP F  +S+ +E ++
Sbjct: 978  EEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009



 Score =  102 bits (253), Expect = 3e-21
 Identities = 51/118 (43%), Positives = 73/118 (61%), Gaps = 1/118 (0%)

Query: 573 IYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPT 632
           + VD  ++  D +WEFPR  LVLG+ LG G FGKVV+ TA+ L        VAVKMLK  
Sbjct: 704 VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN 763

Query: 633 ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
           A  SE + L+SE  ++  +  H +++ L GAC++ GP+ +I EY  YG L  +L ++R
Sbjct: 764 ASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  197 bits (502), Expect = 3e-50
 Identities = 94/212 (44%), Positives = 144/212 (67%), Gaps = 2/212 (0%)

Query: 744  PMLERKEVSKYSDIQRSLYD-RPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV 802
            P+L   E +KY  ++  L + R           S   + L   +   LT+ DL+SF +Q+
Sbjct: 799  PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQI 858

Query: 803  ARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWM 862
            ++GM++LA    VHRDLAARN+L+A+G+ +KI DFGL+RD+  + +YV +    +PVKWM
Sbjct: 859  SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 918

Query: 863  APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHAT 922
            A ES+FD++YTT SDVWS+G+LLWEI +LGG PYPG+  +  F N +K+G+RM +PD+ +
Sbjct: 919  AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCS 977

Query: 923  SEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             E+Y +M++CW  EP+KRP F  +S+ +E ++
Sbjct: 978  EEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009



 Score =  102 bits (253), Expect = 3e-21
 Identities = 51/118 (43%), Positives = 73/118 (61%), Gaps = 1/118 (0%)

Query: 573 IYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPT 632
           + VD  ++  D +WEFPR  LVLG+ LG G FGKVV+ TA+ L        VAVKMLK  
Sbjct: 704 VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN 763

Query: 633 ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
           A  SE + L+SE  ++  +  H +++ L GAC++ GP+ +I EY  YG L  +L ++R
Sbjct: 764 ASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  197 bits (500), Expect = 6e-50
 Identities = 93/172 (54%), Positives = 126/172 (73%), Gaps = 1/172 (0%)

Query: 783 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 842
           S +  E L+  DL+S  YQVARGME+LASK C+HRDLAARNVL+ +  ++KI DFGLARD
Sbjct: 497 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 556

Query: 843 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVD 902
           I H   Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+
Sbjct: 557 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 616

Query: 903 STFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             F   +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ ++
Sbjct: 617 ELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667



 Score =  128 bits (322), Expect = 3e-29
 Identities = 132/496 (26%), Positives = 204/496 (41%), Gaps = 76/496 (15%)

Query: 276 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF 335
           T+PE     S + +     ++ E KE      +     +   +    +L AV   +   F
Sbjct: 26  TLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKF 85

Query: 336 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKI--QEIRYRS-KLKLIRAKEEDSGHY 392
                  P P + WLKN         E   D  +I   ++RY +  + +      D G+Y
Sbjct: 86  KCPSSGTPNPTLRWLKNG-------KEFKPD-HRIGGYKVRYATWSIIMDSVVPSDKGNY 137

Query: 393 TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVR--------CTAEGTPLPD 444
           T + +NE    ++T++L     S    ++    G    +TV         C     P P 
Sbjct: 138 TCIVENEYGSINHTYQLDVVERSPHRPILQA--GLPANKTVALGSNVEFMCKVYSDPQPH 195

Query: 445 IEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAK 504
           I+W+  K I+   ++     L          +++ D+      +     E+     CLA 
Sbjct: 196 IQWL--KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAG 253

Query: 505 NLLGAENRELKL-VAPTLRSELTVAAAVLVLLVIV-------IISLIVLVVIWKQKPRYE 556
           N +G  +    L V   L     V  + L L +I+       I  ++  V+++K K   +
Sbjct: 254 NSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTK 313

Query: 557 ------------------IRWRVIES------------------ISPDGHEYIY-VDPMQ 579
                             +R +V  S                  +S  G   +  V   +
Sbjct: 314 KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYE 373

Query: 580 LPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPTARSSE 637
           LP D RWE PRD LVLG+ LG G FG+VV   A GL + +P  V KVAVKMLK  A   +
Sbjct: 374 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 433

Query: 638 KQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL--- 694
              L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL   R   L   
Sbjct: 434 LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 493

Query: 695 ---SHHPEKPKKELDI 707
              SH+PE+     D+
Sbjct: 494 YNPSHNPEEQLSSKDL 509


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  197 bits (500), Expect = 6e-50
 Identities = 93/172 (54%), Positives = 126/172 (73%), Gaps = 1/172 (0%)

Query: 783 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 842
           S +  E L+  DL+S  YQVARGME+LASK C+HRDLAARNVL+ +  ++KI DFGLARD
Sbjct: 499 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 558

Query: 843 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVD 902
           I H   Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+
Sbjct: 559 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 618

Query: 903 STFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             F   +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ ++
Sbjct: 619 ELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669



 Score =  128 bits (321), Expect = 3e-29
 Identities = 125/449 (27%), Positives = 189/449 (42%), Gaps = 76/449 (16%)

Query: 323 QLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKI--QEIRYRS-KL 379
           +L AV   +   F       P P + WLKN         E   D  +I   ++RY +  +
Sbjct: 75  KLHAVPAAKTVKFKCPSSGTPNPTLRWLKNG-------KEFKPD-HRIGGYKVRYATWSI 126

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVR----- 434
            +      D G+YT + +NE    ++T++L     S    ++    G    +TV      
Sbjct: 127 IMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQA--GLPANKTVALGSNV 184

Query: 435 ---CTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFA 491
              C     P P I+W+  K I+   ++     L          +++ D+      +   
Sbjct: 185 EFMCKVYSDPQPHIQWL--KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 242

Query: 492 KVEETIAVRCLAKNLLGAENRELKL-VAPTLRSELTVAAAVLVLLVIV-------IISLI 543
             E+     CLA N +G  +    L V   L     V  + L L +I+       I  ++
Sbjct: 243 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 302

Query: 544 VLVVIWKQKPRYE------------------IRWRVIES------------------ISP 567
             V+++K K   +                  +R +V  S                  +S 
Sbjct: 303 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 362

Query: 568 DGHEYIY-VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKV 624
            G   +  V   +LP D RWE PRD LVLG+ LG G FG+VV   A GL + +P  V KV
Sbjct: 363 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 422

Query: 625 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 684
           AVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  
Sbjct: 423 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 482

Query: 685 YLHKNRDSFL------SHHPEKPKKELDI 707
           YL   R   L      SH+PE+     D+
Sbjct: 483 YLQARRPPGLEYCYNPSHNPEEQLSSKDL 511


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  197 bits (500), Expect = 6e-50
 Identities = 93/172 (54%), Positives = 126/172 (73%), Gaps = 1/172 (0%)

Query: 783 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 842
           S +  E L+  DL+S  YQVARGME+LASK C+HRDLAARNVL+ +  ++KI DFGLARD
Sbjct: 586 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 645

Query: 843 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVD 902
           I H   Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+
Sbjct: 646 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 705

Query: 903 STFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             F   +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ ++
Sbjct: 706 ELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756



 Score =  128 bits (321), Expect = 3e-29
 Identities = 125/449 (27%), Positives = 189/449 (42%), Gaps = 76/449 (16%)

Query: 323 QLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKI--QEIRYRS-KL 379
           +L AV   +   F       P P + WLKN         E   D  +I   ++RY +  +
Sbjct: 162 KLHAVPAAKTVKFKCPSSGTPNPTLRWLKNG-------KEFKPD-HRIGGYKVRYATWSI 213

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVR----- 434
            +      D G+YT + +NE    ++T++L     S    ++    G    +TV      
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQA--GLPANKTVALGSNV 271

Query: 435 ---CTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFA 491
              C     P P I+W+  K I+   ++     L          +++ D+      +   
Sbjct: 272 EFMCKVYSDPQPHIQWL--KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329

Query: 492 KVEETIAVRCLAKNLLGAENRELKL-VAPTLRSELTVAAAVLVLLVIV-------IISLI 543
             E+     CLA N +G  +    L V   L     V  + L L +I+       I  ++
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 389

Query: 544 VLVVIWKQKPRYE------------------IRWRVIES------------------ISP 567
             V+++K K   +                  +R +V  S                  +S 
Sbjct: 390 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 449

Query: 568 DGHEYIY-VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKV 624
            G   +  V   +LP D RWE PRD LVLG+ LG G FG+VV   A GL + +P  V KV
Sbjct: 450 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 509

Query: 625 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 684
           AVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  
Sbjct: 510 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 569

Query: 685 YLHKNRDSFL------SHHPEKPKKELDI 707
           YL   R   L      SH+PE+     D+
Sbjct: 570 YLQARRPPGLEYCYNPSHNPEEQLSSKDL 598


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  197 bits (500), Expect = 6e-50
 Identities = 93/172 (54%), Positives = 126/172 (73%), Gaps = 1/172 (0%)

Query: 783 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 842
           S +  E L+  DL+S  YQVARGME+LASK C+HRDLAARNVL+ +  ++KI DFGLARD
Sbjct: 588 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 647

Query: 843 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVD 902
           I H   Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+
Sbjct: 648 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 707

Query: 903 STFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             F   +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ ++
Sbjct: 708 ELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758



 Score =  128 bits (321), Expect = 3e-29
 Identities = 125/449 (27%), Positives = 189/449 (42%), Gaps = 76/449 (16%)

Query: 323 QLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKI--QEIRYRS-KL 379
           +L AV   +   F       P P + WLKN         E   D  +I   ++RY +  +
Sbjct: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWLKNG-------KEFKPD-HRIGGYKVRYATWSI 215

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVR----- 434
            +      D G+YT + +NE    ++T++L     S    ++    G    +TV      
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQA--GLPANKTVALGSNV 273

Query: 435 ---CTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFA 491
              C     P P I+W+  K I+   ++     L          +++ D+      +   
Sbjct: 274 EFMCKVYSDPQPHIQWL--KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331

Query: 492 KVEETIAVRCLAKNLLGAENRELKL-VAPTLRSELTVAAAVLVLLVIV-------IISLI 543
             E+     CLA N +G  +    L V   L     V  + L L +I+       I  ++
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391

Query: 544 VLVVIWKQKPRYE------------------IRWRVIES------------------ISP 567
             V+++K K   +                  +R +V  S                  +S 
Sbjct: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 451

Query: 568 DGHEYIY-VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKV 624
            G   +  V   +LP D RWE PRD LVLG+ LG G FG+VV   A GL + +P  V KV
Sbjct: 452 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 511

Query: 625 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 684
           AVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  
Sbjct: 512 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 571

Query: 685 YLHKNRDSFL------SHHPEKPKKELDI 707
           YL   R   L      SH+PE+     D+
Sbjct: 572 YLQARRPPGLEYCYNPSHNPEEQLSSKDL 600


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 508 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 567

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 568 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 626

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 627 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673



 Score =  119 bits (299), Expect = 1e-26
 Identities = 129/487 (26%), Positives = 193/487 (39%), Gaps = 80/487 (16%)

Query: 267 PSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEA 326
           PS  LV   T+       SGD E     A   V E      + +   +   +    +L A
Sbjct: 23  PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRAPY---WTNTEKMEKRLHA 79

Query: 327 VNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---LKLIR 383
           V       F       P P + WLKN     +          +I   + R++   L +  
Sbjct: 80  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSLIMES 131

Query: 384 AKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTVRCTA 437
               D G+YT V +NE    ++T+ L     S    IL      + ST   G     C  
Sbjct: 132 VVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKV 191

Query: 438 EGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETI 497
                P I+W+  K ++K  ++       + +  +    HS   S+    +    V E  
Sbjct: 192 YSDAQPHIQWI--KHVEKNGSKYG----PDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 245

Query: 498 AVR--CLAKNLLGAENRELKLV------APTLRSELTVAA-----AVLVLLVIVIISLIV 544
           A    C   N +G  N+   L       AP    E+T +      A+  + V +I  ++V
Sbjct: 246 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 305

Query: 545 LVVIWKQK------------------PRYEIRWRVIESI--------------------- 565
            V++ + K                   R  +R +V  S                      
Sbjct: 306 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 365

Query: 566 SPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMK 623
           + D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + 
Sbjct: 366 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 425

Query: 624 VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLV 683
           VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L 
Sbjct: 426 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 485

Query: 684 NYLHKNR 690
            YL   R
Sbjct: 486 EYLRARR 492


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 597 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 656

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 657 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 715

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 716 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762



 Score =  119 bits (298), Expect = 2e-26
 Identities = 140/551 (25%), Positives = 215/551 (39%), Gaps = 112/551 (20%)

Query: 228 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD 287
           GE++ V C + +  V+   WT  G   G            ++ +   L +  AT +DSG 
Sbjct: 55  GESLEVRCLLKDAAVIS--WTKDGVHLGPNNR--------TVLIGEYLQIKGATPRDSGL 104

Query: 288 YECAARQATREVKEMKKVTIS------------------VHEKGFIEIKPTFSQLEAVN- 328
           Y C A +          V ++                  V E    +  P ++  E +  
Sbjct: 105 YACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEK 164

Query: 329 -LHEVK-----HFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---L 379
            LH V       F       P P + WLKN     +          +I   + R++   L
Sbjct: 165 RLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSL 216

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTV 433
            +      D G+YT V +NE    ++T+ L     S    IL      + ST   G    
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 276

Query: 434 RCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKV 493
            C       P I+W+  K ++K  ++       + +  +    HS   S+    +    V
Sbjct: 277 VCKVYSDAQPHIQWI--KHVEKNGSKYG----PDGLPYLKVLKHSGINSSNAEVLALFNV 330

Query: 494 EETIAVR--CLAKNLLGAENRELKLV------APTLRSELTVAA-----AVLVLLVIVII 540
            E  A    C   N +G  N+   L       AP    E+T +      A+  + V +I 
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390

Query: 541 SLIVLVVIWKQK------------------PRYEIRWRVIESI----------------- 565
            ++V V++ + K                   R  +R +V  S                  
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450

Query: 566 ----SPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP- 620
               + D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P 
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510

Query: 621 -VMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFY 679
             + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570

Query: 680 GDLVNYLHKNR 690
           G+L  YL   R
Sbjct: 571 GNLREYLRARR 581


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 479 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 538

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 539 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 597

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 598 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644



 Score =  120 bits (301), Expect = 7e-27
 Identities = 115/424 (27%), Positives = 174/424 (41%), Gaps = 66/424 (15%)

Query: 323 QLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---L 379
           +L AV       F       P P + WLKN     +          +I   + R++   L
Sbjct: 50  RLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSL 101

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTV 433
            +      D G+YT V +NE    ++T+ L     S    IL      + ST   G    
Sbjct: 102 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 161

Query: 434 RCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKV 493
            C       P I+W+  K ++K  ++     L          +++ D+      +     
Sbjct: 162 VCKVYSDAQPHIQWI--KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219

Query: 494 EETIAVRCLAKNLLGAENRELKLV---APTLRSELTVAA-----AVLVLLVIVIISLIVL 545
           E+     CLA N +G       L    AP    E+T +      A+  + V +I  ++V 
Sbjct: 220 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279

Query: 546 VVIWKQK------------------PRYEIRWRVIE-------------------SISPD 568
           V++ + K                   R  +R +V                     S + D
Sbjct: 280 VILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTAD 339

Query: 569 GHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAV 626
                 V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + VAV
Sbjct: 340 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV 399

Query: 627 KMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYL 686
           KMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL
Sbjct: 400 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 459

Query: 687 HKNR 690
              R
Sbjct: 460 RARR 463


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 480 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 539

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 540 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 598

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 599 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 645



 Score =  115 bits (289), Expect = 2e-25
 Identities = 57/118 (48%), Positives = 76/118 (64%), Gaps = 2/118 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPT 632
           V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + VAVKMLK  
Sbjct: 347 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 406

Query: 633 ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
           A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL   R
Sbjct: 407 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 464


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 540

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 541 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 599

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 600 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 646



 Score =  120 bits (300), Expect = 9e-27
 Identities = 115/426 (26%), Positives = 174/426 (40%), Gaps = 68/426 (15%)

Query: 323 QLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---L 379
           +L AV       F       P P + WLKN     +          +I   + R++   L
Sbjct: 50  RLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSL 101

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTV 433
            +      D G+YT V +NE    ++T+ L     S    IL      + ST   G    
Sbjct: 102 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 161

Query: 434 RCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKV 493
            C       P I+W+  K ++K  ++     L          +++ D+      +     
Sbjct: 162 VCKVYSDAQPHIQWI--KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219

Query: 494 EETIAVRCLAKNLLGAENRELKLV---APTLRSELTVAA-----AVLVLLVIVIISLIVL 545
           E+     CLA N +G       L    AP    E+T +      A+  + V +I  ++V 
Sbjct: 220 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279

Query: 546 VVIWKQK------------------PRYEIRWRVIESI---------------------S 566
           V++ + K                   R  +R +V  S                      +
Sbjct: 280 VILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSST 339

Query: 567 PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKV 624
            D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + V
Sbjct: 340 ADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTV 399

Query: 625 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 684
           AVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  
Sbjct: 400 AVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 459

Query: 685 YLHKNR 690
           YL   R
Sbjct: 460 YLRARR 465


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 507 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 566

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 567 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 625

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 626 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672



 Score =  121 bits (303), Expect = 4e-27
 Identities = 127/482 (26%), Positives = 191/482 (39%), Gaps = 71/482 (14%)

Query: 267 PSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEA 326
           PS  LV   T+       SGD E     A   V E      + +   +   +    +L A
Sbjct: 23  PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRAPY---WTNTEKMEKRLHA 79

Query: 327 VNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---LKLIR 383
           V       F       P P + WLKN     +          +I   + R++   L +  
Sbjct: 80  VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSLIMES 131

Query: 384 AKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTVRCTA 437
               D G+YT V +NE    ++T+ L     S    IL      + ST   G     C  
Sbjct: 132 VVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKV 191

Query: 438 EGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETI 497
                P I+W+  K ++K  ++     L          +++ D+      +     E+  
Sbjct: 192 YSDAQPHIQWI--KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAG 249

Query: 498 AVRCLAKNLLGAENRELKLV---APTLRSELTVAA-----AVLVLLVIVIISLIVLVVIW 549
              CLA N +G       L    AP    E+T +      A+  + V +I  ++V V++ 
Sbjct: 250 EYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILC 309

Query: 550 KQK------------------PRYEIRWRVIESI---------------------SPDGH 570
           + K                   R  +R +V  S                      + D  
Sbjct: 310 RMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTP 369

Query: 571 EYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKM 628
               V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + VAVKM
Sbjct: 370 MLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKM 429

Query: 629 LKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHK 688
           LK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL  
Sbjct: 430 LKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRA 489

Query: 689 NR 690
            R
Sbjct: 490 RR 491


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 484 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 543

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 544 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 602

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 603 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649



 Score =  122 bits (307), Expect = 1e-27
 Identities = 95/317 (29%), Positives = 143/317 (45%), Gaps = 66/317 (20%)

Query: 425 HGSTGGQTV--RCTAEGTPLPDIEWMIC-KDIKKCNNETSWTILANNVSNIITEIHSRDR 481
           H      TV  RC A G P+P + W+   K+ K+ +    + +   + S I+  +   D+
Sbjct: 167 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 226

Query: 482 STVEGRVTFAKVEETIAVRCLAKNLLGAENR--ELKLVAPTLRSELTVAA-----AVLVL 534
               G  T           C+ +N  G+ N    L +VAP    E+T +      A+  +
Sbjct: 227 ----GNYT-----------CVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCI 271

Query: 535 LVIVIISLIVLVVIWKQK------------------PRYEIRWRVIESI----------- 565
            V +I  ++V V++ + K                   R  +R +V  S            
Sbjct: 272 GVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTP 331

Query: 566 ----------SPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL 615
                     + D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+
Sbjct: 332 LVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGI 391

Query: 616 SRSQP--VMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYII 673
            + +P   + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I
Sbjct: 392 DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVI 451

Query: 674 TEYCFYGDLVNYLHKNR 690
            EY   G+L  YL   R
Sbjct: 452 VEYASKGNLREYLRARR 468


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 596 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 655

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 656 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 714

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 715 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 761



 Score =  120 bits (302), Expect = 5e-27
 Identities = 138/546 (25%), Positives = 213/546 (39%), Gaps = 103/546 (18%)

Query: 228 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD 287
           GE++ V C + +  V+   WT  G   G            ++ +   L +  AT +DSG 
Sbjct: 55  GESLEVRCLLKDAAVIS--WTKDGVHLGPNNR--------TVLIGEYLQIKGATPRDSGL 104

Query: 288 YECAARQATREVKEMKKVTIS------------------VHEKGFIEIKPTFSQLEAVN- 328
           Y C A +          V ++                  V E    +  P ++  E +  
Sbjct: 105 YACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEK 164

Query: 329 -LHEVK-----HFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---L 379
            LH V       F       P P + WLKN     +          +I   + R++   L
Sbjct: 165 RLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSL 216

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTV 433
            +      D G+YT V +NE    ++T+ L     S    IL      + ST   G    
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 276

Query: 434 RCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKV 493
            C       P I+W+  K ++K  ++     L          +++ D+      +     
Sbjct: 277 VCKVYSDAQPHIQWI--KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 334

Query: 494 EETIAVRCLAKNLLGAENRELKLV---APTLRSELTVAA-----AVLVLLVIVIISLIVL 545
           E+     CLA N +G       L    AP    E+T +      A+  + V +I  ++V 
Sbjct: 335 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 394

Query: 546 VVIWKQK------------------PRYEIRWRVIESI---------------------S 566
           V++ + K                   R  +R +V  S                      +
Sbjct: 395 VILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSST 454

Query: 567 PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKV 624
            D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + V
Sbjct: 455 ADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTV 514

Query: 625 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 684
           AVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  
Sbjct: 515 AVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 574

Query: 685 YLHKNR 690
           YL   R
Sbjct: 575 YLRARR 580


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  194 bits (492), Expect = 5e-49
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 597 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 656

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 657 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 715

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 716 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762



 Score =  119 bits (298), Expect = 2e-26
 Identities = 140/551 (25%), Positives = 215/551 (39%), Gaps = 112/551 (20%)

Query: 228 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD 287
           GE++ V C + +  V+   WT  G   G            ++ +   L +  AT +DSG 
Sbjct: 55  GESLEVRCLLKDAAVIS--WTKDGVHLGPNNR--------TVLIGEYLQIKGATPRDSGL 104

Query: 288 YECAARQATREVKEMKKVTIS------------------VHEKGFIEIKPTFSQLEAVN- 328
           Y C A +          V ++                  V E    +  P ++  E +  
Sbjct: 105 YACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEK 164

Query: 329 -LHEVK-----HFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSK---L 379
            LH V       F       P P + WLKN     +          +I   + R++   L
Sbjct: 165 RLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE--------HRIGGYKVRNQHWSL 216

Query: 380 KLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSS---ILDLVDDHHGST---GGQTV 433
            +      D G+YT V +NE    ++T+ L     S    IL      + ST   G    
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 276

Query: 434 RCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKV 493
            C       P I+W+  K ++K  ++       + +  +    HS   S+    +    V
Sbjct: 277 VCKVYSDAQPHIQWI--KHVEKNGSKYG----PDGLPYLKVLKHSGINSSNAEVLALFNV 330

Query: 494 EETIAVR--CLAKNLLGAENRELKLV------APTLRSELTVAA-----AVLVLLVIVII 540
            E  A    C   N +G  N+   L       AP    E+T +      A+  + V +I 
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390

Query: 541 SLIVLVVIWKQK------------------PRYEIRWRVIESI----------------- 565
            ++V V++ + K                   R  +R +V  S                  
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450

Query: 566 ----SPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP- 620
               + D      V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P 
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510

Query: 621 -VMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFY 679
             + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570

Query: 680 GDLVNYLHKNR 690
           G+L  YL   R
Sbjct: 571 GNLREYLRARR 581


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/167 (54%), Positives = 124/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E LT  DL+S  YQVARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARD+ +  
Sbjct: 589 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 648

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+  F  
Sbjct: 649 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF-K 707

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T ++Y IM +CW++ P +RP+F  L E ++ +L
Sbjct: 708 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 754



 Score =  109 bits (272), Expect = 2e-23
 Identities = 129/512 (25%), Positives = 200/512 (39%), Gaps = 98/512 (19%)

Query: 275 LTVPEATVKDSGDYECAARQATR-----EVKEMKKVTISVHEKGFIEIKPTF-------- 321
           L V  A+ +DSG Y C  R   R      V+     +    E G  E + T         
Sbjct: 94  LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153

Query: 322 -------SQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIR 374
                   +L AV       F       P P ISWLKN                +I  I+
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREF--------RGEHRIGGIK 205

Query: 375 YRSK---LKLIRAKEEDSGHYTIVAQNE--DAVKSYTFELLTQVPSSIL---DLVDDHHG 426
            R +   L +      D G+YT V +N+     ++YT ++L + P   +    L  +   
Sbjct: 206 LRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA 265

Query: 427 STGGQT-VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVE 485
             G      C       P I+W+  K +     E + + +  + +  +T + S    +VE
Sbjct: 266 VLGSDVEFHCKVYSDAQPHIQWL--KHV-----EVNGSKVGPDGTPYVTVLKSWISESVE 318

Query: 486 G--RVTFAKVEETIAVR--CLAKNLLGAENRE--LKLVAPTLRSELTVAA---------- 529
              R+  A V E       C A N +G   +   L +  P    E  V A          
Sbjct: 319 ADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGI 378

Query: 530 ---AVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISP------------------- 567
               V   L I++++ + L  + +  P+  +    +  IS                    
Sbjct: 379 LSYGVGFFLFILVVAAVTLCRL-RSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNT 437

Query: 568 -----------DGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLS 616
                      +G     V  ++LP D +WE  R  L LG+ LG G FG+VV   A G+ 
Sbjct: 438 PLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 497

Query: 617 RSQPV--MKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIT 674
           + +    + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y++ 
Sbjct: 498 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 557

Query: 675 EYCFYGDLVNYLHKNRDSFLSHHPE--KPKKE 704
           EY   G+L  +L   R   L +  +  KP +E
Sbjct: 558 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEE 589


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/167 (54%), Positives = 124/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E LT  DL+S  YQVARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARD+ +  
Sbjct: 475 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 534

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+  F  
Sbjct: 535 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF-K 593

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T ++Y IM +CW++ P +RP+F  L E ++ +L
Sbjct: 594 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 640



 Score =  106 bits (264), Expect = 1e-22
 Identities = 58/149 (38%), Positives = 85/149 (57%), Gaps = 4/149 (2%)

Query: 560 RVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQ 619
           R+    S +G     V  ++LP D +WE  R  L LG+ LG G FG+VV   A G+ + +
Sbjct: 327 RIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDR 386

Query: 620 PV--MKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYC 677
               + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y++ EY 
Sbjct: 387 AAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYA 446

Query: 678 FYGDLVNYLHKNRDSFLSHHPE--KPKKE 704
             G+L  +L   R   L +  +  KP +E
Sbjct: 447 AKGNLREFLRARRPPGLDYSFDTCKPPEE 475


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/167 (54%), Positives = 124/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E LT  DL+S  YQVARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARD+ +  
Sbjct: 587 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 646

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+  F  
Sbjct: 647 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF-K 705

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T ++Y IM +CW++ P +RP+F  L E ++ +L
Sbjct: 706 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 752



 Score =  112 bits (280), Expect = 2e-24
 Identities = 126/510 (24%), Positives = 202/510 (39%), Gaps = 96/510 (18%)

Query: 275 LTVPEATVKDSGDYECAARQATR-----EVKEMKKVTISVHEKGFIEIKPTF-------- 321
           L V  A+ +DSG Y C  R   R      V+     +    E G  E + T         
Sbjct: 94  LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153

Query: 322 -------SQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIR 374
                   +L AV       F       P P ISWLKN                +I  I+
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREF--------RGEHRIGGIK 205

Query: 375 YRSK---LKLIRAKEEDSGHYTIVAQNE--DAVKSYTFELLTQVPSSIL---DLVDDHHG 426
            R +   L +      D G+YT V +N+     ++YT ++L + P   +    L  +   
Sbjct: 206 LRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA 265

Query: 427 STGGQT-VRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVE 485
             G      C       P I+W+  K +     E + + +  + +  +T + +   +T +
Sbjct: 266 VLGSDVEFHCKVYSDAQPHIQWL--KHV-----EVNGSKVGPDGTPYVTVLKTAGANTTD 318

Query: 486 GRVTFAKV-----EETIAVRCLAKNLLGAENRELKLVAPTLRSEL-------TVAAAVL- 532
             +    +     E+     CLA N +G  +    LV      EL       +V A +L 
Sbjct: 319 KELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILS 378

Query: 533 ----VLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISP--------------------- 567
                 L I++++ + L  + +  P+  +    +  IS                      
Sbjct: 379 YGVGFFLFILVVAAVTLCRL-RSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL 437

Query: 568 ---------DGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRS 618
                    +G     V  ++LP D +WE  R  L LG+ LG G FG+VV   A G+ + 
Sbjct: 438 VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKD 497

Query: 619 QPV--MKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEY 676
           +    + VAVKMLK  A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y++ EY
Sbjct: 498 RAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY 557

Query: 677 CFYGDLVNYLHKNRDSFLSHHPE--KPKKE 704
              G+L  +L   R   L +  +  KP +E
Sbjct: 558 AAKGNLREFLRARRPPGLDYSFDTCKPPEE 587


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  187 bits (475), Expect = 5e-47
 Identities = 88/170 (51%), Positives = 124/170 (72%), Gaps = 2/170 (1%)

Query: 786 NSEG-LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIM 844
           +SEG L+   L+S  YQVARGM++L S+ C+HRDLAARNVL+ +  ++KI DFGLAR + 
Sbjct: 539 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 598

Query: 845 HDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDST 904
           H   Y    +  LPVKWMAPE++FD +YT  SDVWS+GILLWEIF+LGG+PYPG+ V+  
Sbjct: 599 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL 658

Query: 905 FYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
           F + ++ G+RM +P H   E+Y +M +CW++ P +RP+F  L E ++ +L
Sbjct: 659 F-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707



 Score =  110 bits (276), Expect = 6e-24
 Identities = 56/127 (44%), Positives = 77/127 (60%), Gaps = 2/127 (1%)

Query: 578 MQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPTARS 635
           + LP D  WEFPRD LVLG+ LG G FG+VV   A+G+  ++P     VAVKMLK  A  
Sbjct: 412 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 471

Query: 636 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS 695
            +   L+SE+++M  +G H NI+NLLG CT+ GP+Y+I E    G+L  +L   R     
Sbjct: 472 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPD 531

Query: 696 HHPEKPK 702
             P+ P+
Sbjct: 532 LSPDGPR 538


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  187 bits (475), Expect = 5e-47
 Identities = 88/170 (51%), Positives = 124/170 (72%), Gaps = 2/170 (1%)

Query: 786 NSEG-LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIM 844
           +SEG L+   L+S  YQVARGM++L S+ C+HRDLAARNVL+ +  ++KI DFGLAR + 
Sbjct: 579 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 638

Query: 845 HDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDST 904
           H   Y    +  LPVKWMAPE++FD +YT  SDVWS+GILLWEIF+LGG+PYPG+ V+  
Sbjct: 639 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL 698

Query: 905 FYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
           F + ++ G+RM +P H   E+Y +M +CW++ P +RP+F  L E ++ +L
Sbjct: 699 F-SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747



 Score =  110 bits (276), Expect = 6e-24
 Identities = 56/127 (44%), Positives = 77/127 (60%), Gaps = 2/127 (1%)

Query: 578 MQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPTARS 635
           + LP D  WEFPRD LVLG+ LG G FG+VV   A+G+  ++P     VAVKMLK  A  
Sbjct: 452 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 511

Query: 636 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS 695
            +   L+SE+++M  +G H NI+NLLG CT+ GP+Y+I E    G+L  +L   R     
Sbjct: 512 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPD 571

Query: 696 HHPEKPK 702
             P+ P+
Sbjct: 572 LSPDGPR 578


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,625,559
Number of Sequences: 37866
Number of extensions: 1923978
Number of successful extensions: 9836
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 549
Number of HSP's successfully gapped in prelim test: 411
Number of HSP's that attempted gapping in prelim test: 5700
Number of HSP's gapped (non-prelim): 2727
length of query: 1089
length of database: 18,247,518
effective HSP length: 113
effective length of query: 976
effective length of database: 13,968,660
effective search space: 13633412160
effective search space used: 13633412160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.