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Search of human proteins with 53832007
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|53832007 calcium channel, voltage-dependent, L type, alpha
1F subunit [Homo sapiens]
(1977 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 3975 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 2397 0.0
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 2390 0.0
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 2379 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 2311 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 2296 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 2295 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 2294 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 2286 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 2284 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 2284 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 2283 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 2282 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 2281 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 2279 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 2279 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 2278 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 2276 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 2276 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 2274 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 2271 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 2266 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 2239 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 2216 0.0
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 2084 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 765 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 761 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 756 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 736 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 327 7e-89
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 3975 bits (10309), Expect = 0.0
Identities = 1977/1977 (100%), Positives = 1977/1977 (100%)
Query: 1 MSESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTV 60
MSESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTV
Sbjct: 1 MSESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTV 60
Query: 61 AVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDS 120
AVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDS
Sbjct: 61 AVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDS 120
Query: 121 NTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLL 180
NTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLL
Sbjct: 121 NTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLL 180
Query: 181 EQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHI 240
EQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHI
Sbjct: 181 EQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHI 240
Query: 241 ALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECR 300
ALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECR
Sbjct: 241 ALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECR 300
Query: 301 GRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGS 360
GRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGS
Sbjct: 301 GRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGS 360
Query: 361 FFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPS 420
FFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPS
Sbjct: 361 FFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPS 420
Query: 421 ADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTE 480
ADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTE
Sbjct: 421 ADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTE 480
Query: 481 TQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVF 540
TQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVF
Sbjct: 481 TQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVF 540
Query: 541 LNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFV 600
LNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFV
Sbjct: 541 LNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFV 600
Query: 601 VCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLL 660
VCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLL
Sbjct: 601 VCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLL 660
Query: 661 LLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDG 720
LLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDG
Sbjct: 661 LLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDG 720
Query: 721 IMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEK 780
IMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEK
Sbjct: 721 IMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEK 780
Query: 781 DLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKE 840
DLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKE
Sbjct: 781 DLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKE 840
Query: 841 KVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFR 900
KVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFR
Sbjct: 841 KVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFR 900
Query: 901 NHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSS 960
NHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSS
Sbjct: 901 NHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSS 960
Query: 961 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQ 1020
AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQ
Sbjct: 961 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQ 1020
Query: 1021 LFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALF 1080
LFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALF
Sbjct: 1021 LFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALF 1080
Query: 1081 TVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITF 1140
TVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITF
Sbjct: 1081 TVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITF 1140
Query: 1141 RAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLI 1200
RAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLI
Sbjct: 1141 RAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLI 1200
Query: 1201 LLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDAL 1260
LLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDAL
Sbjct: 1201 LLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDAL 1260
Query: 1261 IVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTF 1320
IVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTF
Sbjct: 1261 IVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTF 1320
Query: 1321 IKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCA 1380
IKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCA
Sbjct: 1321 IKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCA 1380
Query: 1381 TGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
TGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVI
Sbjct: 1381 TGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP
Sbjct: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR
Sbjct: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG
Sbjct: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVS 1680
LRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVS
Sbjct: 1621 LRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVS 1680
Query: 1681 LPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGT 1740
LPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGT
Sbjct: 1681 LPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGT 1740
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRK 1800
KGQNKQDEDEEVPDRLSYLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRK
Sbjct: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRK 1800
Query: 1801 PSFTIQCLQRQGSCEDLPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAA 1860
PSFTIQCLQRQGSCEDLPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAA
Sbjct: 1801 PSFTIQCLQRQGSCEDLPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAA 1860
Query: 1861 GEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVAL 1920
GEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVAL
Sbjct: 1861 GEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVAL 1920
Query: 1921 AKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMACVHAL 1977
AKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMACVHAL
Sbjct: 1921 AKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMACVHAL 1977
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 2397 bits (6213), Expect = 0.0
Identities = 1202/1628 (73%), Positives = 1357/1628 (83%), Gaps = 70/1628 (4%)
Query: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
Query: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
Query: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
Query: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
Query: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYWM DAMG+ELP
Sbjct: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELP 382
Query: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
Query: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
TQAE++D E+ E G G R +
Sbjct: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
Query: 469 SLPASDTGSM-TETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVK 527
S+P S+T S+ TE E E G C I K+++ RR RR NR R RCR AVK
Sbjct: 465 SMPTSETESVNTENVSGEGENRGC---CGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVK 521
Query: 528 SNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSA 587
S YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL LFT EML+K+Y LG A
Sbjct: 522 SVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQA 581
Query: 588 YVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVA 647
Y S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLLRIFKVTRHW SLSNLVA
Sbjct: 582 YFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 641
Query: 648 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQI 707
SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TKRSTFD FPQALLTVFQI
Sbjct: 642 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQI 701
Query: 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDA- 766
LTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILLNVFLAIAVDNLA ++
Sbjct: 702 LTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESL 761
Query: 767 GTAKDKGGEKSNEKDLPQ--------------------ENEGLVPGVEKEEEEGARREGA 806
TA+ + E+ K + + +N+ + +E+E+
Sbjct: 762 NTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC 821
Query: 807 DMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHT 866
D+ EEEEEEEE+E E + E+ KEK+ PIPEGSAFF LS+TNP+R GCH
Sbjct: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
Query: 867 LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDYAFT+IFTVEILLKMT F
Sbjct: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
Query: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
GAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILRVLRVLRPLRAINRAKGL
Sbjct: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGL 1001
Query: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLV 1046
KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY CTDEAK P+EC+G F++
Sbjct: 1002 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFIL 1061
Query: 1047 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPI 1106
Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWPALLYKAID+ E+ GPI
Sbjct: 1062 YKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPI 1121
Query: 1107 YNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALK 1166
YN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+NCELDKNQRQCVEYALK
Sbjct: 1122 YNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
Query: 1167 AQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILN 1226
A+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAMQHYEQ+ FN AMDILN
Sbjct: 1182 ARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILN 1241
Query: 1227 MVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSED 1286
MVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+A++E +N SE+
Sbjct: 1242 MVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADN-------SEE 1294
Query: 1287 SSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGM 1346
S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLIAM+FFIYAVIGM
Sbjct: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354
Query: 1347 QMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGP 1406
QMFGKVA++D QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA LPG CDPESD+ P
Sbjct: 1355 QMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNP 1414
Query: 1407 GEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1466
GEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW
Sbjct: 1415 GEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1474
Query: 1467 SEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNAT 1526
SEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTV FNAT
Sbjct: 1475 SEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNAT 1534
Query: 1527 LFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYAT 1586
LFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+ KLLD+V+PP ++EVTVGKFYAT
Sbjct: 1535 LFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYAT 1594
Query: 1587 FLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEEEG 1646
FLIQDYFRKF++RKE+GL+G A +T+ ALQAGLR+L D+GPE+R+A++CD +++E E
Sbjct: 1595 FLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEE 1654
Query: 1647 QEGVEEED 1654
+ EE+D
Sbjct: 1655 TKREEEDD 1662
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1877 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1936
Query: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1937 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 1996
Query: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 1997 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2056
Query: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 2057 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2116
Query: 1956 ESILSRFDEEDLGDEMACVHAL 1977
E R DEEDL DEM C+ L
Sbjct: 2117 EPDPGR-DEEDLADEMICITTL 2137
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 2390 bits (6195), Expect = 0.0
Identities = 1201/1636 (73%), Positives = 1357/1636 (82%), Gaps = 71/1636 (4%)
Query: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
Query: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
Query: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
Query: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
Query: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYWM DAMG+ELP
Sbjct: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELP 382
Query: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 383 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
Query: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
TQAE++D E+ E G G R +
Sbjct: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
Query: 469 SLPASDTGSM-TETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVK 527
S+P S+T S+ TE E E G C I K+++ RR RR NR R RCR AVK
Sbjct: 465 SMPTSETESVNTENVSGEGENRGC---CGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVK 521
Query: 528 SNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSA 587
S YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL LFT EML+K+Y LG A
Sbjct: 522 SVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQA 581
Query: 588 YVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVA 647
Y S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLLRIFKVTRHW SLSNLVA
Sbjct: 582 YFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 641
Query: 648 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQI 707
SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TKRSTFD FPQALLTVFQI
Sbjct: 642 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQI 701
Query: 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDA- 766
LTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILLNVFLAIAVDNLA ++
Sbjct: 702 LTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESL 761
Query: 767 GTAKDKGGEKSNEKDLPQ--------------------ENEGLVPGVEKEEEEGARREGA 806
TA+ + E+ K + + +N+ + +E+E+
Sbjct: 762 NTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPC 821
Query: 807 DMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHT 866
D+ EEEEEEEE+E E + E+ KEK+ PIPEGSAFF LS+TNP+R GCH
Sbjct: 822 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 881
Query: 867 LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDYAFT+IFTVEILLKMT F
Sbjct: 882 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 941
Query: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
GAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILRVLRVLRPLRAINRAKGL
Sbjct: 942 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGL 1001
Query: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLV 1046
KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY CTDEAK P+EC+G F++
Sbjct: 1002 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFIL 1061
Query: 1047 YPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPI 1106
Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWPALLYKAID+ E+ GPI
Sbjct: 1062 YKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPI 1121
Query: 1107 YNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALK 1166
YN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+NCELDKNQRQCVEYALK
Sbjct: 1122 YNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
Query: 1167 AQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILN 1226
A+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAMQHYEQ+ FN AMDILN
Sbjct: 1182 ARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILN 1241
Query: 1227 MVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGH------- 1279
MVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+A++E +
Sbjct: 1242 MVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPT 1301
Query: 1280 -LGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIF 1338
+SE+S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLIAM+F
Sbjct: 1302 ATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1361
Query: 1339 FIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRC 1398
FIYAVIGMQMFGKVA++D QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA LPG C
Sbjct: 1362 FIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLC 1421
Query: 1399 DPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1458
DPESD+ PGEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH
Sbjct: 1422 DPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1481
Query: 1459 LDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD 1518
LDEFKRIWSEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD
Sbjct: 1482 LDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSD 1541
Query: 1519 GTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEV 1578
GTV FNATLFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+ KLLD+V+PP ++EV
Sbjct: 1542 GTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEV 1601
Query: 1579 TVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCD 1638
TVGKFYATFLIQDYFRKF++RKE+GL+G A +T+ ALQAGLR+L D+GPE+R+A++CD
Sbjct: 1602 TVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCD 1661
Query: 1639 TEEEEEEGQEGVEEED 1654
+++E E + EE+D
Sbjct: 1662 LQDDEPEETKREEEDD 1677
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1901 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1960
Query: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1961 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2020
Query: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 2021 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2080
Query: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 2081 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2140
Query: 1956 ESILSRFDEEDLGDEMACVHAL 1977
E R DEEDL DEM C+ L
Sbjct: 2141 EPDPGR-DEEDLADEMICITTL 2161
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 2379 bits (6165), Expect = 0.0
Identities = 1198/1653 (72%), Positives = 1357/1653 (82%), Gaps = 85/1653 (5%)
Query: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
Query: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
Query: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
Query: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
Query: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYW+ DA+G+E P
Sbjct: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWP 382
Query: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
WVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 383 WVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
Query: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
TQAE++D E+ E G G R +
Sbjct: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
Query: 469 SLPASDTGSM-TETQGDEDEEEGALAS-----------------CTRCLNKIMKTRVCRR 510
S+P S+T S+ TE E E G S C R I K+++ RR
Sbjct: 465 SMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRR 524
Query: 511 LRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLC 570
RR NR R RCR AVKS YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL
Sbjct: 525 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLA 584
Query: 571 LFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLL 630
LFT EML+K+Y LG AY S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLL
Sbjct: 585 LFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLL 644
Query: 631 RIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK 690
RIFKVTRHW SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TK
Sbjct: 645 RIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK 704
Query: 691 RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILL 750
RSTFD FPQALLTVFQILTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILL
Sbjct: 705 RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILL 764
Query: 751 NVFLAIAVDNLASGDA-GTAKDKGGEKSNEKDLPQ--------------------ENEGL 789
NVFLAIAVDNLA ++ TA+ + E+ K + + +N+
Sbjct: 765 NVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVT 824
Query: 790 VPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGS 849
+ +E+E+ D+ EEEEEEEE+E E + E+ KEK+ PIPEGS
Sbjct: 825 IDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGS 884
Query: 850 AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDY 909
AFF LS+TNP+R GCH LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDY
Sbjct: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDY 944
Query: 910 AFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILR 969
AFT+IFTVEILLKMT FGAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILR
Sbjct: 945 AFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILR 1004
Query: 970 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTC 1029
VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY C
Sbjct: 1005 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRC 1064
Query: 1030 TDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWP 1089
TDEAK P+EC+G F++Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWP
Sbjct: 1065 TDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWP 1124
Query: 1090 ALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQ 1149
ALLYKAID+ E+ GPIYN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+
Sbjct: 1125 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYK 1184
Query: 1150 NCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1209
NCELDKNQRQCVEYALKA+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAM
Sbjct: 1185 NCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM 1244
Query: 1210 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1269
QHYEQ+ FN AMDILNMVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+
Sbjct: 1245 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1304
Query: 1270 AVTEVNNGGH--------LGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFI 1321
A++E + +SE+S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFI
Sbjct: 1305 ALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1364
Query: 1322 KSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCAT 1381
KSFQALPYVALLIAM+FFIYAVIGMQMFGKVA++D QINRNNNFQTFPQAVLLLFRCAT
Sbjct: 1365 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1424
Query: 1382 GEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIM 1441
GEAWQEIMLA LPG CDPESD+ PGEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIM
Sbjct: 1425 GEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIM 1484
Query: 1442 DNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPH 1501
DNFDYLTRDWSILGPHHLDEFKRIWSEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPH
Sbjct: 1485 DNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPH 1544
Query: 1502 RVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRM 1561
RVACKRLVAMNMPLNSDGTV FNATLFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+
Sbjct: 1545 RVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKT 1604
Query: 1562 KQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGL 1621
KLLD+V+PP ++EVTVGKFYATFLIQDYFRKF++RKE+GL+G A +T+ ALQAGL
Sbjct: 1605 SMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGL 1664
Query: 1622 RSLQDLGPEMRQALTCDTEEEEEEGQEGVEEED 1654
R+L D+GPE+R+A++CD +++E E + EE+D
Sbjct: 1665 RTLHDIGPEIRRAISCDLQDDEPEETKREEEDD 1697
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
Query: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
Query: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
Query: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
Query: 1956 ESILSRFDEEDLGDEMACVHAL 1977
E R DEEDL DEM C+ L
Sbjct: 2161 EPDPGR-DEEDLADEMICITTL 2181
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 2311 bits (5990), Expect = 0.0
Identities = 1275/2147 (59%), Positives = 1499/2147 (69%), Gaps = 233/2147 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYWMQ
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQ 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL------------------- 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1659 --------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSV 1710
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1715 RSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANI 1767
Query: 1711 PQAGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGT 1740
A + R G + + T+ EG+ P
Sbjct: 1768 NNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM 1825
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVP 1787
GQ + +DE ++++ E P L P +R D P
Sbjct: 1826 AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSP 1883
Query: 1788 RRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNS 1829
+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1884 KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1943
Query: 1830 GPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------G 1866
P +ATPP RG L EG L G
Sbjct: 1944 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2003
Query: 1867 RSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEI 1925
SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+
Sbjct: 2004 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2063
Query: 1926 ADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2064 ADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2108
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 2296 bits (5949), Expect = 0.0
Identities = 1265/2143 (59%), Positives = 1494/2143 (69%), Gaps = 236/2143 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQA 1326
VDIA+TEVNN +E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQA
Sbjct: 1296 VDIAITEVNN-------AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1348
Query: 1327 LPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQ 1386
LPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1349 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1408
Query: 1387 EIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNF
Sbjct: 1409 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Query: 1445 DYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVA 1504
DYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVA
Sbjct: 1469 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1528
Query: 1505 CKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQK 1564
CKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR K
Sbjct: 1529 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMK 1588
Query: 1565 LLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSL 1624
LLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAGLR+L
Sbjct: 1589 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAGLRTL 1647
Query: 1625 QDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL----------------------- 1658
D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1648 HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF 1707
Query: 1659 ----ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAG 1714
T + +++ + +G S P ++L DS +F PS + T S ++ A
Sbjct: 1708 PQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANINNAN 1760
Query: 1715 SNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGTKGQN 1744
+ R G + + T+ EG+ P GQ
Sbjct: 1761 NTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQE 1818
Query: 1745 KQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVPRRRL 1791
+ +DE ++++ E P L P +R D P+R
Sbjct: 1819 ETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSPKRGF 1876
Query: 1792 LPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNSGPNR 1833
L GR+ SF ++CL+RQ G LP+ +H+ R+ P
Sbjct: 1877 LRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPAS 1936
Query: 1834 AQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------GRSSG 1870
+ATPP RG L EG L G SS
Sbjct: 1937 FPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSA 1996
Query: 1871 PLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADAC 1929
R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+ADAC
Sbjct: 1997 ARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADAC 2056
Query: 1930 RLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
+T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2057 DMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2097
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 2295 bits (5948), Expect = 0.0
Identities = 1265/2147 (58%), Positives = 1495/2147 (69%), Gaps = 233/2147 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL------------------- 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1659 --------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSV 1710
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1715 RSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANI 1767
Query: 1711 PQAGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGT 1740
A + R G + + T+ EG+ P
Sbjct: 1768 NNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM 1825
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVP 1787
GQ + +DE ++++ E P L P +R D P
Sbjct: 1826 AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSP 1883
Query: 1788 RRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNS 1829
+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1884 KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1943
Query: 1830 GPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------G 1866
P +ATPP RG L EG L G
Sbjct: 1944 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2003
Query: 1867 RSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEI 1925
SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+
Sbjct: 2004 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2063
Query: 1926 ADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2064 ADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2108
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 2294 bits (5944), Expect = 0.0
Identities = 1264/2147 (58%), Positives = 1494/2147 (69%), Gaps = 233/2147 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL------------------- 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1659 --------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSV 1710
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1715 RSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANI 1767
Query: 1711 PQAGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGT 1740
A + R G + + T+ EG+ P
Sbjct: 1768 NNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM 1825
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVP 1787
GQ + +DE ++++ E P L P +R D P
Sbjct: 1826 AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSP 1883
Query: 1788 RRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNS 1829
+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1884 KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1943
Query: 1830 GPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------G 1866
P +ATPP RG L EG L G
Sbjct: 1944 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2003
Query: 1867 RSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEI 1925
SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+
Sbjct: 2004 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2063
Query: 1926 ADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2064 ADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2108
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 2286 bits (5925), Expect = 0.0
Identities = 1266/2167 (58%), Positives = 1496/2167 (69%), Gaps = 253/2167 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 F--------------------DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLL 946
F DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLL
Sbjct: 936 FDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 995
Query: 947 VVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIV 1006
VVSVSLISFGI SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IV
Sbjct: 996 VVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIV 1055
Query: 1007 TTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD 1066
TTLLQFMFACIGVQLFKGK YTC+D +K T ECKG+++ Y DG+V P+++ R W NS
Sbjct: 1056 TTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSK 1115
Query: 1067 FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAF 1126
F+FDNVL+AMMALFTVSTFEGWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAF
Sbjct: 1116 FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAF 1175
Query: 1127 FMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWAT 1186
FMMNIFVGFVI+TF+ QGEQEY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW
Sbjct: 1176 FMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYV 1235
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
VNS FEYLMF+LILLNT+ LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKP
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMR 1302
KHYF DAWNTFDALIVVGSIVDIA+TEVN H ++E++SRISITFFRLFRVMR
Sbjct: 1296 KHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMR 1355
Query: 1303 LVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINR 1362
LVKLLS+GEGIRTLLWTFIKSFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INR
Sbjct: 1356 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1415
Query: 1363 NNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAY 1420
NNNFQTFPQAVLLLFRCATGEAWQ+IMLA +PG +C PES+ E CGS+FA+ Y
Sbjct: 1416 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1475
Query: 1421 FISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHL 1480
FISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHL
Sbjct: 1476 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1535
Query: 1481 DVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE 1540
DVV LLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE
Sbjct: 1536 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1595
Query: 1541 GNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRK 1600
GNLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RK
Sbjct: 1596 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1655
Query: 1601 EKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKD 1657
E+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D
Sbjct: 1656 EQGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1714
Query: 1658 L---------------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDS 1690
+ T + +++ + +G S P ++L DS
Sbjct: 1715 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS 1771
Query: 1691 LSFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP-------- 1737
+F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1772 -TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQ 1825
Query: 1738 -----------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC------------ 1768
GQ + +DE ++++ E P
Sbjct: 1826 EVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDE 1885
Query: 1769 -SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIP 1820
L P +R D P+R L GR+ SF ++CL+RQ G LP+
Sbjct: 1886 NRQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLH 1943
Query: 1821 GTYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL 1865
+H+ R+ P +ATPP RG L EG L
Sbjct: 1944 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 2003
Query: 1866 -------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLIS 1905
G SS R L VP P GSA SLVEAVLIS
Sbjct: 2004 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2063
Query: 1906 EGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEE 1965
EGLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L +
Sbjct: 2064 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCR 2121
Query: 1966 DLGDEMA 1972
D G + A
Sbjct: 2122 DAGQDRA 2128
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 2284 bits (5919), Expect = 0.0
Identities = 1265/2162 (58%), Positives = 1494/2162 (69%), Gaps = 255/2162 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQA 1326
VDIA+TEVNN +E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQA
Sbjct: 1296 VDIAITEVNN-------AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1348
Query: 1327 LPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQ 1386
LPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1349 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1408
Query: 1387 EIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNF
Sbjct: 1409 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Query: 1445 DYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVA 1504
DYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVA
Sbjct: 1469 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1528
Query: 1505 CKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------GNLEQ 1545
CKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE GNLEQ
Sbjct: 1529 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1588
Query: 1546 ANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLL 1605
AN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+
Sbjct: 1589 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1648
Query: 1606 GNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL---- 1658
G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1649 GKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1707
Query: 1659 -----------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGP 1695
T + +++ + +G S P ++L DS +F P
Sbjct: 1708 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTP 1763
Query: 1696 SDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP------------- 1737
S + T S ++ A + R G + + T+ EG+ P
Sbjct: 1764 SS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWK 1818
Query: 1738 ------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLL 1772
GQ + +DE ++++ E P L
Sbjct: 1819 LSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLT 1878
Query: 1773 PPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHR 1825
P +R D P+R L GR+ SF ++CL+RQ G LP+ +H+
Sbjct: 1879 LPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQ 1936
Query: 1826 G-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL----- 1865
R+ P +ATPP RG L EG L
Sbjct: 1937 ALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFP 1996
Query: 1866 --------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGL 1910
G SS R L VP P GSA SLVEAVLISEGLG
Sbjct: 1997 SIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQ 2056
Query: 1911 FARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDE 1970
FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D G +
Sbjct: 2057 FAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQD 2114
Query: 1971 MA 1972
A
Sbjct: 2115 RA 2116
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 2284 bits (5918), Expect = 0.0
Identities = 1265/2166 (58%), Positives = 1495/2166 (69%), Gaps = 252/2166 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------G 1541
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1542 NLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKE 1601
NLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1602 KGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL 1658
+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1656 QGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1659 ---------------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSL 1691
T + +++ + +G S P ++L DS
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS- 1770
Query: 1692 SFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP--------- 1737
+F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1771 TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQE 1825
Query: 1738 ----------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC------------- 1768
GQ + +DE ++++ E P
Sbjct: 1826 VAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDEN 1885
Query: 1769 SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPG 1821
L P +R D P+R L GR+ SF ++CL+RQ G LP+
Sbjct: 1886 RQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHL 1943
Query: 1822 TYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL- 1865
+H+ R+ P +ATPP RG L EG L
Sbjct: 1944 VHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLN 2003
Query: 1866 ------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISE 1906
G SS R L VP P GSA SLVEAVLISE
Sbjct: 2004 SSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISE 2063
Query: 1907 GLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEED 1966
GLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D
Sbjct: 2064 GLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRD 2121
Query: 1967 LGDEMA 1972
G + A
Sbjct: 2122 AGQDRA 2127
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 2283 bits (5915), Expect = 0.0
Identities = 1264/2162 (58%), Positives = 1493/2162 (69%), Gaps = 255/2162 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQA 1326
VDIA+TEVNN +E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQA
Sbjct: 1296 VDIAITEVNN-------AEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1348
Query: 1327 LPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQ 1386
LPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1349 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1408
Query: 1387 EIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNF
Sbjct: 1409 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Query: 1445 DYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVA 1504
DYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVA
Sbjct: 1469 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1528
Query: 1505 CKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------GNLEQ 1545
CKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE GNLEQ
Sbjct: 1529 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1588
Query: 1546 ANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLL 1605
AN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+
Sbjct: 1589 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1648
Query: 1606 GNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL---- 1658
G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1649 GKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1707
Query: 1659 -----------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGP 1695
T + +++ + +G S P ++L DS +F P
Sbjct: 1708 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTP 1763
Query: 1696 SDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP------------- 1737
S + T S ++ A + R G + + T+ EG+ P
Sbjct: 1764 SS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWK 1818
Query: 1738 ------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLL 1772
GQ + +DE ++++ E P L
Sbjct: 1819 LSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLT 1878
Query: 1773 PPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHR 1825
P +R D P+R L GR+ SF ++CL+RQ G LP+ +H+
Sbjct: 1879 LPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQ 1936
Query: 1826 G-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL----- 1865
R+ P +ATPP RG L EG L
Sbjct: 1937 ALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFP 1996
Query: 1866 --------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGL 1910
G SS R L VP P GSA SLVEAVLISEGLG
Sbjct: 1997 SIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQ 2056
Query: 1911 FARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDE 1970
FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D G +
Sbjct: 2057 FAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQD 2114
Query: 1971 MA 1972
A
Sbjct: 2115 RA 2116
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 2282 bits (5914), Expect = 0.0
Identities = 1264/2166 (58%), Positives = 1494/2166 (68%), Gaps = 252/2166 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------G 1541
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1542 NLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKE 1601
NLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1602 KGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL 1658
+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1656 QGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1659 ---------------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSL 1691
T + +++ + +G S P ++L DS
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS- 1770
Query: 1692 SFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP--------- 1737
+F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1771 TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQE 1825
Query: 1738 ----------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC------------- 1768
GQ + +DE ++++ E P
Sbjct: 1826 VAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDEN 1885
Query: 1769 SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPG 1821
L P +R D P+R L GR+ SF ++CL+RQ G LP+
Sbjct: 1886 RQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHL 1943
Query: 1822 TYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL- 1865
+H+ R+ P +ATPP RG L EG L
Sbjct: 1944 VHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLN 2003
Query: 1866 ------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISE 1906
G SS R L VP P GSA SLVEAVLISE
Sbjct: 2004 SSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISE 2063
Query: 1907 GLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEED 1966
GLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D
Sbjct: 2064 GLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRD 2121
Query: 1967 LGDEMA 1972
G + A
Sbjct: 2122 AGQDRA 2127
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 2281 bits (5910), Expect = 0.0
Identities = 1265/2171 (58%), Positives = 1494/2171 (68%), Gaps = 264/2171 (12%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPK------------------- 1247
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1295
Query: 1248 ---------HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLF 1298
HYF DAWNTFDALIVVGSIVDIA+TEVNN +E++SRISITFFRLF
Sbjct: 1296 IDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNN-------AEENSRISITFFRLF 1348
Query: 1299 RVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGT 1358
RVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T
Sbjct: 1349 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTT 1408
Query: 1359 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNF 1416
+INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLA +PG +C PES+ E CGS+F
Sbjct: 1409 EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1468
Query: 1417 AIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGR 1476
A+ YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGR
Sbjct: 1469 AVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR 1528
Query: 1477 IKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLK 1536
IKHLDVV LLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+
Sbjct: 1529 IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALR 1588
Query: 1537 IKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKF 1596
IKTEGNLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF
Sbjct: 1589 IKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKF 1648
Query: 1597 RRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEE 1653
++RKE+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V
Sbjct: 1649 KKRKEQGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAA 1707
Query: 1654 DEKDL---------------------------ETNKATMVSQPSARRGSGISVSLPVGDR 1686
E D+ T + +++ + +G S P ++
Sbjct: 1708 SEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEK 1764
Query: 1687 LPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP---- 1737
L DS +F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1765 LVDS-TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPA 1818
Query: 1738 ---------------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC-------- 1768
GQ + +DE ++++ E P
Sbjct: 1819 IRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSY 1878
Query: 1769 -----SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED--- 1816
L P +R D P+R L GR+ SF ++CL+RQ G
Sbjct: 1879 QDDENRQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTV 1936
Query: 1817 LPIPGTYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAG 1861
LP+ +H+ R+ P +ATPP RG L EG
Sbjct: 1937 LPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVES 1996
Query: 1862 EGYL-------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEA 1901
L G SS R L VP P GSA SLVEA
Sbjct: 1997 SEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2056
Query: 1902 VLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSR 1961
VLISEGLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L
Sbjct: 2057 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPF 2114
Query: 1962 FDEEDLGDEMA 1972
+ D G + A
Sbjct: 2115 VNCRDAGQDRA 2125
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 2279 bits (5906), Expect = 0.0
Identities = 1255/2147 (58%), Positives = 1490/2147 (69%), Gaps = 233/2147 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK YF+D WN FD LIV+GSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
+D+ ++E N H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 IDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL------------------- 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1659 --------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSV 1710
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1715 RSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANI 1767
Query: 1711 PQAGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGT 1740
A + R G + + T+ EG+ P
Sbjct: 1768 NNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM 1825
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVP 1787
GQ + +DE ++++ E P L P +R D P
Sbjct: 1826 AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSP 1883
Query: 1788 RRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNS 1829
+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1884 KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1943
Query: 1830 GPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------G 1866
P +ATPP RG L EG L G
Sbjct: 1944 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2003
Query: 1867 RSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEI 1925
SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+
Sbjct: 2004 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2063
Query: 1926 ADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2064 ADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2108
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 2279 bits (5905), Expect = 0.0
Identities = 1264/2175 (58%), Positives = 1494/2175 (68%), Gaps = 261/2175 (12%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPK------------------- 1247
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1295
Query: 1248 ---------HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHL----GESSEDSSRISITF 1294
HYF DAWNTFDALIVVGSIVDIA+TEVN H ++E++SRISITF
Sbjct: 1296 IDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1355
Query: 1295 FRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVAL 1354
FRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLI M+FFIYAVIGMQ+FGK+AL
Sbjct: 1356 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1415
Query: 1355 QDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE--EFTC 1412
D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLA +PG +C PES+ E C
Sbjct: 1416 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1475
Query: 1413 GSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPG 1472
GS+FA+ YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDP
Sbjct: 1476 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE 1535
Query: 1473 AKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVR 1532
AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTV FNATLFALVR
Sbjct: 1536 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVR 1595
Query: 1533 TSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDY 1592
T+L+IKTEGNLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+Y
Sbjct: 1596 TALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEY 1655
Query: 1593 FRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEG 1649
FRKF++RKE+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E
Sbjct: 1656 FRKFKKRKEQGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEA 1714
Query: 1650 VEEEDEKDL---------------------------ETNKATMVSQPSARRGSGISVSLP 1682
V E D+ T + +++ + +G S P
Sbjct: 1715 VSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---P 1771
Query: 1683 VGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP 1737
++L DS +F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1772 SHEKLVDS-TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPP 1825
Query: 1738 -------------------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC---- 1768
GQ + +DE ++++ E P
Sbjct: 1826 LSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTE 1885
Query: 1769 ---------SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCE 1815
L P +R D P+R L GR+ SF ++CL+RQ G
Sbjct: 1886 MLSYQDDENRQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDIS 1943
Query: 1816 D---LPIPGTYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEE 1857
LP+ +H+ R+ P +ATPP RG L E
Sbjct: 1944 QKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLE 2003
Query: 1858 GAAGEGYL-------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADS 1897
G L G SS R L VP P GSA S
Sbjct: 2004 GVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASS 2063
Query: 1898 LVEAVLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEES 1957
LVEAVLISEGLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S +
Sbjct: 2064 LVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGA 2121
Query: 1958 ILSRFDEEDLGDEMA 1972
+L + D G + A
Sbjct: 2122 LLPFVNCRDAGQDRA 2136
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 2278 bits (5902), Expect = 0.0
Identities = 1254/2147 (58%), Positives = 1489/2147 (69%), Gaps = 233/2147 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK YF+D WN FD LIV+GSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
+D+ ++E N H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 IDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL------------------- 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDG 1714
Query: 1659 --------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSV 1710
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1715 RSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANI 1767
Query: 1711 PQAGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGT 1740
A + R G + + T+ EG+ P
Sbjct: 1768 NNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM 1825
Query: 1741 KGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVP 1787
GQ + +DE ++++ E P L P +R D P
Sbjct: 1826 AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSP 1883
Query: 1788 RRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNS 1829
+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1884 KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSH 1943
Query: 1830 GPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------G 1866
P +ATPP RG L EG L G
Sbjct: 1944 SPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGG 2003
Query: 1867 RSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEI 1925
SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+
Sbjct: 2004 GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQEL 2063
Query: 1926 ADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2064 ADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2108
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 2276 bits (5898), Expect = 0.0
Identities = 1261/2162 (58%), Positives = 1491/2162 (68%), Gaps = 257/2162 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQA 1326
VDIA+T E++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQA
Sbjct: 1296 VDIAIT---------ENAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1346
Query: 1327 LPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQ 1386
LPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ
Sbjct: 1347 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1406
Query: 1387 EIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNF
Sbjct: 1407 DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1466
Query: 1445 DYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVA 1504
DYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVA
Sbjct: 1467 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA 1526
Query: 1505 CKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------GNLEQ 1545
CKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE GNLEQ
Sbjct: 1527 CKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ 1586
Query: 1546 ANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLL 1605
AN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+
Sbjct: 1587 ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1646
Query: 1606 GNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL---- 1658
G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1647 GKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA 1705
Query: 1659 -----------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGP 1695
T + +++ + +G S P ++L DS +F P
Sbjct: 1706 GGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTP 1761
Query: 1696 SDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP------------- 1737
S + T S ++ A + R G + + T+ EG+ P
Sbjct: 1762 SS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWK 1816
Query: 1738 ------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLL 1772
GQ + +DE ++++ E P L
Sbjct: 1817 LSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLT 1876
Query: 1773 PPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHR 1825
P +R D P+R L GR+ SF ++CL+RQ G LP+ +H+
Sbjct: 1877 LPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQ 1934
Query: 1826 G-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL----- 1865
R+ P +ATPP RG L EG L
Sbjct: 1935 ALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFP 1994
Query: 1866 --------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGL 1910
G SS R L VP P GSA SLVEAVLISEGLG
Sbjct: 1995 SIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQ 2054
Query: 1911 FARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDE 1970
FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D G +
Sbjct: 2055 FAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQD 2112
Query: 1971 MA 1972
A
Sbjct: 2113 RA 2114
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 2276 bits (5897), Expect = 0.0
Identities = 1253/2145 (58%), Positives = 1487/2145 (69%), Gaps = 232/2145 (10%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPC 283
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY + AE+DPSPC
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ-EGIAAEDDPSPC 313
Query: 284 A-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDA 342
A +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+ DA
Sbjct: 314 ALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 372
Query: 343 MGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLR 402
+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+
Sbjct: 373 VGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLK 432
Query: 403 GYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTH 462
GYLDWITQAE++D E+ +EG +P+
Sbjct: 433 GYLDWITQAEDIDPEN----------EDEGMDEEKPR----------------------- 459
Query: 463 STSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARC 522
+ S+P S+T S+ + EG R ++I K++ R RR NR R +C
Sbjct: 460 ----NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRRKC 514
Query: 523 RRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYG 582
R AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+Y
Sbjct: 515 RAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYS 574
Query: 583 LGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASL 642
LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W SL
Sbjct: 575 LGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSL 634
Query: 643 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALL 702
SNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+LL
Sbjct: 635 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLL 694
Query: 703 TVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 762
TVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA
Sbjct: 695 TVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA 754
Query: 763 SGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA-------- 806
++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 755 DAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPP 814
Query: 807 -------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEG 848
D++ E E+ EE+EEE E L E+ KEK VP+PE
Sbjct: 815 ATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEA 874
Query: 849 SAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFD 908
SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL YFD
Sbjct: 875 SAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFD 934
Query: 909 YAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKIL 968
FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVKIL
Sbjct: 935 IVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKIL 994
Query: 969 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYT 1028
RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK YT
Sbjct: 995 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1054
Query: 1029 CTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGW 1088
C+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFEGW
Sbjct: 1055 CSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGW 1114
Query: 1089 PALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEY 1148
P LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQEY
Sbjct: 1115 PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEY 1174
Query: 1149 QNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALA 1208
+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+ LA
Sbjct: 1175 KNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLA 1234
Query: 1209 MQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVD 1268
MQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK YF+D WN FD LIV+GSI+D
Sbjct: 1235 MQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIID 1294
Query: 1269 IAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSF 1324
+ ++E N H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSF
Sbjct: 1295 VILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSF 1354
Query: 1325 QALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEA 1384
QALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEA
Sbjct: 1355 QALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEA 1414
Query: 1385 WQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMD 1442
WQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMD
Sbjct: 1415 WQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD 1474
Query: 1443 NFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHR 1502
NFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHR
Sbjct: 1475 NFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1534
Query: 1503 VACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMK 1562
VACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1535 VACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTS 1594
Query: 1563 QKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLR 1622
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAGLR
Sbjct: 1595 MKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAGLR 1653
Query: 1623 SLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL--------------------- 1658
+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1654 TLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRS 1713
Query: 1659 ------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQ 1712
T + +++ + +G S P ++L DS +F PS + T S ++
Sbjct: 1714 AFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANINN 1766
Query: 1713 AGSNTHRR-----GSGALIFTIPEEGNSQP-------------------------KGTKG 1742
A + R G + + T+ EG+ P G
Sbjct: 1767 ANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAG 1824
Query: 1743 QNKQDEDEEVPDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVPRR 1789
Q + +DE ++++ E P L P +R D P+R
Sbjct: 1825 QEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSPKR 1882
Query: 1790 RLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNSGP 1831
L GR+ SF ++CL+RQ G LP+ +H+ R+ P
Sbjct: 1883 GFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSP 1942
Query: 1832 NRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL-------------------GRS 1868
+ATPP RG L EG L G S
Sbjct: 1943 ASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGS 2002
Query: 1869 SGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIAD 1927
S R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+AD
Sbjct: 2003 SAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELAD 2062
Query: 1928 ACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
AC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2063 ACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2105
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 2274 bits (5894), Expect = 0.0
Identities = 1264/2188 (57%), Positives = 1495/2188 (68%), Gaps = 274/2188 (12%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHLG--------------------------ESSEDSSRISITFFRLFRV 1300
VDIA+TEVN H +++E++SRISITFFRLFRV
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRV 1355
Query: 1301 MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQI 1360
MRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+I
Sbjct: 1356 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1415
Query: 1361 NRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAI 1418
NRNNNFQTFPQAVLLLFRCATGEAWQ+IMLA +PG +C PES+ E CGS+FA+
Sbjct: 1416 NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1475
Query: 1419 AYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIK 1478
YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIK
Sbjct: 1476 FYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIK 1535
Query: 1479 HLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIK 1538
HLDVV LLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IK
Sbjct: 1536 HLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIK 1595
Query: 1539 TE-------------------GNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVT 1579
TE GNLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVT
Sbjct: 1596 TEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVT 1655
Query: 1580 VGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDT 1639
VGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAGLR+L D+GPE+R+A++ D
Sbjct: 1656 VGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDL 1714
Query: 1640 EEEEE---EGQEGVEEEDEKDL---------------------------ETNKATMVSQP 1669
EEE +E V E D+ T + +++
Sbjct: 1715 TAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKA 1774
Query: 1670 SARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGA 1724
+ +G S P ++L DS +F PS + T S ++ A + R G +
Sbjct: 1775 GSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPS 1827
Query: 1725 LIFTIPEEGNSQP-------------------------KGTKGQNKQDEDEEVPDRLSYL 1759
+ T+ EG+ P GQ + +DE ++++
Sbjct: 1828 TVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHD 1885
Query: 1760 DEQAGTPPC-------------SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQ 1806
E P L P +R D P+R L GR+ SF ++
Sbjct: 1886 TEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLE 1943
Query: 1807 CLQRQ----GSCED---LPIPGTYHRG-----------RNSGPNRAQGSWATPP----QR 1844
CL+RQ G LP+ +H+ R+ P +ATPP R
Sbjct: 1944 CLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSR 2003
Query: 1845 GRLLYAPLLLVEEGAAGEGYL-------------------GRSSGPLRTF-TCLHVPGTH 1884
G L EG L G SS R L VP
Sbjct: 2004 GWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQA 2063
Query: 1885 SDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLL 1944
P GSA SLVEAVLISEGLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L
Sbjct: 2064 GAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNIL 2123
Query: 1945 AQGTSSLYSDEESILSRFDEEDLGDEMA 1972
+ G S ++L + D G + A
Sbjct: 2124 SGGAPQ--SPNGALLPFVNCRDAGQDRA 2149
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 2271 bits (5886), Expect = 0.0
Identities = 1266/2195 (57%), Positives = 1496/2195 (68%), Gaps = 281/2195 (12%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 F--------------------DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLL 946
F DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLL
Sbjct: 936 FDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 995
Query: 947 VVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIV 1006
VVSVSLISFGI SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IV
Sbjct: 996 VVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIV 1055
Query: 1007 TTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD 1066
TTLLQFMFACIGVQLFKGK YTC+D +K T ECKG+++ Y DG+V P+++ R W NS
Sbjct: 1056 TTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSK 1115
Query: 1067 FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAF 1126
F+FDNVL+AMMALFTVSTFEGWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAF
Sbjct: 1116 FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAF 1175
Query: 1127 FMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWAT 1186
FMMNIFVGFVI+TF+ QGEQEY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW
Sbjct: 1176 FMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYV 1235
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
VNS FEYLMF+LILLNT+ LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKP
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1247 K----------------------------HYFTDAWNTFDALIVVGSIVDIAVTEVNNGG 1278
K HYF DAWNTFDALIVVGSIVDIA+TEVN
Sbjct: 1296 KGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAE 1355
Query: 1279 HL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLI 1334
H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLI
Sbjct: 1356 HTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1335 AMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLP 1394
M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLA +P
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1395 GNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWS 1452
G +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWS
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1535
Query: 1453 ILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMN 1512
ILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLV+MN
Sbjct: 1536 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1595
Query: 1513 MPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPP 1572
MPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR KLLD+V+PP
Sbjct: 1596 MPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1655
Query: 1573 PDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMR 1632
++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAGLR+L D+GPE+R
Sbjct: 1656 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAGLRTLHDIGPEIR 1714
Query: 1633 QALTCDTEEEEE---EGQEGVEEEDEKDL---------------------------ETNK 1662
+A++ D EEE +E V E D+ T +
Sbjct: 1715 RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR 1774
Query: 1663 ATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRR-- 1720
+++ + +G S P ++L DS +F PS + T S ++ A + R
Sbjct: 1775 PLHINKAGSSQGDTES---PSHEKLVDS-TFTPSS---YSSTGSNANINNANNTALGRLP 1827
Query: 1721 ---GSGALIFTIPEEGNSQP-------------------------KGTKGQNKQDEDEEV 1752
G + + T+ EG+ P GQ + +DE
Sbjct: 1828 RPAGYPSTVSTV--EGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETY 1885
Query: 1753 PDRLSYLDEQAGTPPC-------------SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGR 1799
++++ E P L P +R D P+R L GR
Sbjct: 1886 EVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKR--DIRQSPKRGFLRSASLGR 1943
Query: 1800 KPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RNSGPNRAQGSWATP 1841
+ SF ++CL+RQ G LP+ +H+ R+ P +ATP
Sbjct: 1944 RASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATP 2003
Query: 1842 P----QRGRLLYAPLLLVEEGAAGEGYL-------------------GRSSGPLRTF-TC 1877
P RG L EG L G SS R
Sbjct: 2004 PATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVS 2063
Query: 1878 LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTLDEMD 1937
L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE+ADAC +T++EM+
Sbjct: 2064 LMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEME 2123
Query: 1938 NAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
+AA ++L+ G S ++L + D G + A
Sbjct: 2124 SAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2156
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 2266 bits (5872), Expect = 0.0
Identities = 1254/2166 (57%), Positives = 1489/2166 (68%), Gaps = 252/2166 (11%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
FD FT+IFT+EI LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPK YF+D WN FD LIV+GSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
+D+ ++E N H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 IDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE-------------------G 1541
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTE G
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAG 1595
Query: 1542 NLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKE 1601
NLEQAN+ELR +IKKIWKR KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE
Sbjct: 1596 NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE 1655
Query: 1602 KGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL 1658
+GL+G + + S LQAGLR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1656 QGLVGKPSQRNALS-LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1714
Query: 1659 ---------------------------ETNKATMVSQPSARRGSGISVSLPVGDRLPDSL 1691
T + +++ + +G S P ++L DS
Sbjct: 1715 FRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTES---PSHEKLVDS- 1770
Query: 1692 SFGPSDDDRGTPTSSQPSVPQAGSNTHRR-----GSGALIFTIPEEGNSQP--------- 1737
+F PS + T S ++ A + R G + + T+ EG+ P
Sbjct: 1771 TFTPSS---YSSTGSNANINNANNTALGRLPRPAGYPSTVSTV--EGHGPPLSPAIRVQE 1825
Query: 1738 ----------------KGTKGQNKQDEDEEVPDRLSYLDEQAGTPPC------------- 1768
GQ + +DE ++++ E P
Sbjct: 1826 VAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDEN 1885
Query: 1769 SVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPG 1821
L P +R D P+R L GR+ SF ++CL+RQ G LP+
Sbjct: 1886 RQLTLPEEDKR--DIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHL 1943
Query: 1822 TYHRG-----------RNSGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL- 1865
+H+ R+ P +ATPP RG L EG L
Sbjct: 1944 VHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLN 2003
Query: 1866 ------------------GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISE 1906
G SS R L VP P GSA SLVEAVLISE
Sbjct: 2004 SSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISE 2063
Query: 1907 GLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEED 1966
GLG FA+DP+F+ + QE+ADAC +T++EM++AA ++L+ G S ++L + D
Sbjct: 2064 GLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRD 2121
Query: 1967 LGDEMA 1972
G + A
Sbjct: 2122 AGQDRA 2127
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 2239 bits (5803), Expect = 0.0
Identities = 1162/1721 (67%), Positives = 1341/1721 (77%), Gaps = 108/1721 (6%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHILG
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGN 935
Query: 907 FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVK 966
DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLLVVSVSLISFGI SSAI+VVK
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFE 1086
YTC+D +K T ECKG+++ Y DG+V P+++ R W NS F+FDNVL+AMMALFTVSTFE
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1115
Query: 1087 GWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ 1146
GWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAFFMMNIFVGFVI+TF+ QGEQ
Sbjct: 1116 GWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ 1175
Query: 1147 EYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVA 1206
EY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW VNS FEYLMF+LILLNT+
Sbjct: 1176 EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTIC 1235
Query: 1207 LAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSI 1266
LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKPKHYF DAWNTFDALIVVGSI
Sbjct: 1236 LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSI 1295
Query: 1267 VDIAVTEVNNGGHL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIK 1322
VDIA+TEVN H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIK
Sbjct: 1296 VDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1355
Query: 1323 SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATG 1382
SFQALPYVALLI M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATG
Sbjct: 1356 SFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATG 1415
Query: 1383 EAWQEIMLASLPGNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVI 1440
EAWQ+IMLA +PG +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVI
Sbjct: 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1441 MDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCP 1500
MDNFDYLTRDWSILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCP
Sbjct: 1476 MDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1535
Query: 1501 HRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKR 1560
HRVACKRLV+MNMPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR
Sbjct: 1536 HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR 1595
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAG 1620
KLLD+V+PP ++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAG
Sbjct: 1596 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAG 1654
Query: 1621 LRSLQDLGPEMRQALTCDTEEEEE---EGQEGVEEEDEKDL 1658
LR+L D+GPE+R+A++ D EEE +E V E D+
Sbjct: 1655 LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDI 1695
Score = 84.0 bits (206), Expect = 1e-15
Identities = 74/228 (32%), Positives = 101/228 (44%), Gaps = 44/228 (19%)
Query: 1787 PRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RN 1828
P+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1918 PKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1977
Query: 1829 SGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL------------------- 1865
P +ATPP RG L EG L
Sbjct: 1978 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2037
Query: 1866 GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQE 1924
G SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE
Sbjct: 2038 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2097
Query: 1925 IADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
+ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2098 LADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2143
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 2216 bits (5741), Expect = 0.0
Identities = 1163/1769 (65%), Positives = 1342/1769 (75%), Gaps = 156/1769 (8%)
Query: 5 EGGKDTTPEPSPAN-----GAGPGPEWGLCPGPP---------AVEGESSGASG------ 44
+G +P P+ AN AG PE PG A + + G++G
Sbjct: 16 QGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATIST 75
Query: 45 -LGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIF 103
T ++R Q+ K K +A R PRAL CLTL NP+RR+CISIVEWKPF+I+ILLTIF
Sbjct: 76 VSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIF 135
Query: 104 ANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGW 163
ANCVAL +YIPFPEDDSN N NLE+VEY+FL+IFTVE LK++AYGL+ HP+AY+RNGW
Sbjct: 136 ANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195
Query: 164 NLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSL 223
NLLDFIIVVVGLFS +LEQ G A GGK GFDVKALRAFRVLRPLRLVSGVPSL
Sbjct: 196 NLLDFIIVVVGLFSAILEQATKADG-ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSL 254
Query: 224 HIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG--SDMEAEEDPS 281
+VLNSI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTCY +D+ AE+DPS
Sbjct: 255 QVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPS 314
Query: 282 PCA-SSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
PCA +G GR C N T C+ W GP GITNFDNF FAMLTVFQC+TMEGWTDVLYW+
Sbjct: 315 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373
Query: 341 DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEED 400
DA+G + PW+YFV+L+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EED
Sbjct: 374 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 433
Query: 401 LRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRS 460
L+GYLDWITQAE++D E+ +EG +P+
Sbjct: 434 LKGYLDWITQAEDIDPEN----------EDEGMDEEKPR--------------------- 462
Query: 461 THSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRA 520
+ S+P S+T S+ + EG R ++I K++ R RR NR R
Sbjct: 463 ------NMSMPTSETESVNTENVAGGDIEGENCG-ARLAHRISKSKFSRYWRRWNRFCRR 515
Query: 521 RCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKL 580
+CR AVKSN YW V+ LVFLNTLTIASEH+ QP WLT++Q+ ANK LL LFT EMLLK+
Sbjct: 516 KCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKM 575
Query: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Y LG AY S FNRFDCFVVCGGILET LVE M PLGISVLRCVRLLRIFK+TR+W
Sbjct: 576 YSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWN 635
Query: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+ T+RSTFD FPQ+
Sbjct: 636 SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQS 695
Query: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
LLTVFQILTGEDWN VMYDGIMAYGGP FPGMLVCIYFIILFICGNYILLNVFLAIAVDN
Sbjct: 696 LLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Query: 761 LASGDAGTAKDKGGEKSNEKD------LPQENEGLV--PGVEKEEEEGARREGA------ 806
LA ++ T+ K E+ E+ P++ + LV P V + +EE +
Sbjct: 756 LADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGES 815
Query: 807 ---------DMEEEEEEE-----------EEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
D++ E E+ EE+EEE E L E+ KEK VP+P
Sbjct: 816 PPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMP 875
Query: 847 EGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
E SAFF S N R CH +++ +FTNLIL FI+LSS+SLAAEDP++ SFRNHIL Y
Sbjct: 876 EASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFY 935
Query: 907 F--------------------DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLL 946
F DY FTSIFT+EI+LKMT +GAFLH+GSFCR++FN+LDLL
Sbjct: 936 FDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLL 995
Query: 947 VVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIV 1006
VVSVSLISFGI SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IV
Sbjct: 996 VVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIV 1055
Query: 1007 TTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD 1066
TTLLQFMFACIGVQLFKGK YTC+D +K T ECKG+++ Y DG+V P+++ R W NS
Sbjct: 1056 TTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSK 1115
Query: 1067 FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAF 1126
F+FDNVL+AMMALFTVSTFEGWP LLY++ID++ ED GPIYNYRVEIS+FFI+YIIIIAF
Sbjct: 1116 FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAF 1175
Query: 1127 FMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWAT 1186
FMMNIFVGFVI+TF+ QGEQEY+NCELDKNQRQCVEYALKA+PLRRYIPKN HQY+VW
Sbjct: 1176 FMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYV 1235
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
VNS FEYLMF+LILLNT+ LAMQHY Q+ F AM+ILNM+FTGLFT+EM+LK+IAFKP
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1247 K----------------------------HYFTDAWNTFDALIVVGSIVDIAVTEVNNGG 1278
K HYF DAWNTFDALIVVGSIVDIA+TEVN
Sbjct: 1296 KGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAE 1355
Query: 1279 HL----GESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLI 1334
H ++E++SRISITFFRLFRVMRLVKLLS+GEGIRTLLWTFIKSFQALPYVALLI
Sbjct: 1356 HTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1335 AMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLP 1394
M+FFIYAVIGMQ+FGK+AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLA +P
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1395 GNRCDPESDFGPGE--EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWS 1452
G +C PES+ E CGS+FA+ YFISF+MLCAFLIINLFVAVIMDNFDYLTRDWS
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1535
Query: 1453 ILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMN 1512
ILGPHHLDEFKRIW+EYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPHRVACKRLV+MN
Sbjct: 1536 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1595
Query: 1513 MPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPP 1572
MPLNSDGTV FNATLFALVRT+L+IKTEGNLEQAN+ELR +IKKIWKR KLLD+V+PP
Sbjct: 1596 MPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1655
Query: 1573 PDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMR 1632
++EVTVGKFYATFLIQ+YFRKF++RKE+GL+G + + S LQAGLR+L D+GPE+R
Sbjct: 1656 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS-LQAGLRTLHDIGPEIR 1714
Query: 1633 QALTCDTEEEEE---EGQEGVEEEDEKDL 1658
+A++ D EEE +E V E D+
Sbjct: 1715 RAISGDLTAEEELDKAMKEAVSAASEDDI 1743
Score = 84.0 bits (206), Expect = 1e-15
Identities = 74/228 (32%), Positives = 101/228 (44%), Gaps = 44/228 (19%)
Query: 1787 PRRRLLPPTPAGRKPSFTIQCLQRQ----GSCED---LPIPGTYHRG-----------RN 1828
P+R L GR+ SF ++CL+RQ G LP+ +H+ R+
Sbjct: 1966 PKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 2025
Query: 1829 SGPNRAQGSWATPP----QRGRLLYAPLLLVEEGAAGEGYL------------------- 1865
P +ATPP RG L EG L
Sbjct: 2026 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2085
Query: 1866 GRSSGPLRTF-TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQE 1924
G SS R L VP P GSA SLVEAVLISEGLG FA+DP+F+ + QE
Sbjct: 2086 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2145
Query: 1925 IADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMA 1972
+ADAC +T++EM++AA ++L+ G S ++L + D G + A
Sbjct: 2146 LADACDMTIEEMESAADNILSGGAPQ--SPNGALLPFVNCRDAGQDRA 2191
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 2084 bits (5399), Expect = 0.0
Identities = 1110/1931 (57%), Positives = 1359/1931 (70%), Gaps = 176/1931 (9%)
Query: 67 RSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHN 126
R PRALFCLTL NPLR++CISIVEWKPF+ +ILLTIFANCVAL VY+P PEDD+N+ N
Sbjct: 26 RPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLG 85
Query: 127 LEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR 186
LE++EY FL++F++E +KI+AYG + H AY+R+GWN+LDF IV +G+F+V+LEQ
Sbjct: 86 LEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVI 145
Query: 187 PGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLF 246
K G DVKALRAFRVLRPLRLVSGVPSL +VLNSI KA++PL HIALLVLF
Sbjct: 146 QSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLF 205
Query: 247 VIIIYAIIGLELFLGRMHKTCYFLGSDMEA---EEDPSPCASSGSGRACTLNQTECRGRW 303
++IIYAIIGLELF G+MHKTCYF+G+D+ A E+PSPCA +GSGR CT+N +ECRG W
Sbjct: 206 MVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGW 265
Query: 304 PGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFV 363
PGPN GIT+FDNF F+MLTV+QC+TMEGWTDVLYW+ DA+G E PW+YFV+L++ GSFF+
Sbjct: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
Query: 364 LNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADD 423
LNLVLGVLSGEF+KEREKAK+RG FQK REKQQ++EDLRGY+ WITQ E +D+ED
Sbjct: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVED----- 380
Query: 424 NLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQG 483
R G+L SDT S+ E G
Sbjct: 381 ----------------------FREGKLS---------------LDEGGSDTESLYEIAG 403
Query: 484 DEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNT 543
LNKI++ R R+ NR+ R +C VKS YW V+L+V LNT
Sbjct: 404 ---------------LNKIIQ--FIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNT 446
Query: 544 LTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCG 603
L+IASEHH QP+WLT++Q+ AN+VLL LFT EML+K+YGLG Y S FNRFDCFVVC
Sbjct: 447 LSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCS 506
Query: 604 GILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLL 663
GILE LVE GAM PLGISVLRC+RLLRIFK+T++W SLSNLVASLLNS++SIASLLLLL
Sbjct: 507 GILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLL 566
Query: 664 FLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMA 723
FLFI+IF+LLGMQLFGG+++F+ T +RS FD FPQAL++VFQ+LTGEDW +MY+GIMA
Sbjct: 567 FLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 724 YGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTA--KDKGGEKSNEK- 780
YGGP +PGMLVCIYFIILF+CGNYILLNVFLAIAVDNLA ++ T+ K K EK K
Sbjct: 627 YGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKM 686
Query: 781 --DLPQENEGLVPGVEKEEEEGARREG----ADMEEEEEEE----------------EEE 818
LP ++E + K+ E+ + EG A ++ +E E ++E
Sbjct: 687 SKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDE 746
Query: 819 EEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLIL 878
E+E E + L E+ KEK VPIPE S+FF S TN +R CH +++ FTN IL
Sbjct: 747 EDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFIL 806
Query: 879 VFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRS 938
+FI+LSS +LAAEDPIRA S RN IL +FD FTS+FTVEI+LKMT +GAFLH+GSFCR+
Sbjct: 807 LFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRN 866
Query: 939 WFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIR 998
+FNMLDLLVV+VSLIS G+ SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI
Sbjct: 867 YFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIS 926
Query: 999 TIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVR 1058
TIGNI++VTTLLQFMFACIGVQLFKGKF+ CTD +K T +EC+G + VY DGD + +R
Sbjct: 927 TIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELR 986
Query: 1059 ERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFI 1118
R WV+SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAID+ AED GPIYN RVE+++FFI
Sbjct: 987 HREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFI 1046
Query: 1119 VYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNP 1178
+YII+IAFFMMNIFVGFVI+TF+ QGE EY+NCELDKNQRQCV+YALKA+PLR YIPKNP
Sbjct: 1047 IYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNP 1106
Query: 1179 HQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMV 1238
+QY+VW V S+ FEYLMF LI+LNT+ L MQHY Q+ N+ DILN+ FT +FT+EM+
Sbjct: 1107 YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMI 1166
Query: 1239 LKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNN-----------GGHLGE-SSED 1286
LK++AFK + YF D WN FD LIV+GSI+D+ ++E++ GG G ++
Sbjct: 1167 LKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226
Query: 1287 SSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGM 1346
S+RIS FFRLFRVMRL+KLLS+ EG+RTLLWTFIKSFQALPYVALLI M+FFIYAVIGM
Sbjct: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
Query: 1347 QMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGP 1406
QMFGK+AL DGTQINRNNNFQTFPQAVLLLFRCATGEAWQEI+LA G CDPESD+ P
Sbjct: 1287 QMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAP 1346
Query: 1407 GEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1466
GEE+TCG+NFA YFISF+MLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW
Sbjct: 1347 GEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIW 1406
Query: 1467 SEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNAT 1526
+EYDP AKGRIKHLDVV LLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTVTFNAT
Sbjct: 1407 AEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNAT 1466
Query: 1527 LFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYAT 1586
LFALVRT+LKIKTEGN EQAN+ELR +IKKIWKR KLLD+VIPP ++EVTVGKFYAT
Sbjct: 1467 LFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYAT 1526
Query: 1587 FLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSL-QDLGPEMRQALTCDTEEEEEE 1645
FLIQ++FRKF +R+E+ +QAGLR++ ++ PE+ + ++ D EEE
Sbjct: 1527 FLIQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEEL 1584
Query: 1646 GQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSD-DDRGTPT 1704
+ VE E+ + + Q S+ + ++ P L F + ++ +P
Sbjct: 1585 ERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRP--LQFAEIEMEEMESPV 1642
Query: 1705 ------SSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGTKGQNKQDEDEEVPDRLS- 1757
+ P A +NT+ + GNS + + + E P+
Sbjct: 1643 FLEDFPQDPRTNPLARANTNNANANVAY------GNSNHSNSHVFSSVHYEREFPEETET 1696
Query: 1758 -YLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCED 1816
+A PC VL P + M L+ +R + P G+ P QC + + S +
Sbjct: 1697 PATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAM----PRGQAPPAPCQCPRVESSMPE 1752
Query: 1817 ---LPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAAGEGYLGRSSGPLR 1873
PG+ H TP
Sbjct: 1753 DRKSSTPGSLHE-------------ETP-------------------------------- 1767
Query: 1874 TFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTL 1933
H T + S + L++ L+ GLG A D F+ Q +ADAC++
Sbjct: 1768 -----HSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEP 1822
Query: 1934 DEMDNAASDLL 1944
+E++ A++LL
Sbjct: 1823 EEVEIMATELL 1833
Score = 214 bits (545), Expect = 7e-55
Identities = 174/695 (25%), Positives = 313/695 (45%), Gaps = 121/695 (17%)
Query: 829 GVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSL 888
G+ Q P +++P P A FCL+ NPLRK C +++ F +IL+ I + V+L
Sbjct: 10 GLRKKQPKKPVPEILPRPP-RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVAL 68
Query: 889 AAEDPIRAHSFRNHILGY--FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLL 946
A P+ + LG +Y F +F++E +K+ +G H+ ++ RS +N+LD
Sbjct: 69 AVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFT 128
Query: 947 VVSVSLISFGI--------HSSAISV------VKILRVLRVLRPLRAINRAKGLKHVVQC 992
+V + + + + H++ +S VK LR RVLRPLR ++ L+ V+
Sbjct: 129 IVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNS 188
Query: 993 VFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TC----TDEAKHTPQECKGSFLVY 1047
+F A+ + +I ++ + ++A IG++LFKGK + TC TD E
Sbjct: 189 IFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE-------- 240
Query: 1048 PDGDVSRPLVRERLWVNSD-------------FNFDNVLSAMMALFTVSTFEGWPALLYK 1094
+R R +N +FDN +M+ ++ T EGW +LY
Sbjct: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW 300
Query: 1095 AIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQE------- 1147
DA + IY F+ I++ +FF++N+ +G + F + E+
Sbjct: 301 VNDAIGNEWPWIY---------FVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQ 351
Query: 1148 --YQNCELDKNQRQCVEYALKAQ----------------------------PLRRYIPKN 1177
+ +LD++ R + + + + L + I
Sbjct: 352 KLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
Query: 1178 PHQYRVW---------ATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMV 1228
H +R W V S F +L+ L++ LNT+++A +H+ Q DI N V
Sbjct: 412 RH-WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRV 470
Query: 1229 FTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSS 1288
LFT EM++K+ + YF +N FD +V I++I + E S +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVE----------SGAMT 520
Query: 1289 RISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQM 1348
+ I+ R R++R+ K+ + L+ + + S +++ + LL+ + I+A++GMQ+
Sbjct: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
Query: 1349 FGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE 1408
FG + T++ R +NF FPQA++ +F+ TGE W +M + GP
Sbjct: 581 FGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-------GP-- 630
Query: 1409 EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDN 1443
+ YFI F+ ++++N+F+A+ +DN
Sbjct: 631 --SYPGMLVCIYFIILFVCGNYILLNVFLAIAVDN 663
Score = 114 bits (286), Expect = 7e-25
Identities = 100/357 (28%), Positives = 155/357 (43%), Gaps = 54/357 (15%)
Query: 56 KHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPF 115
K K V + A + F + N +R C IV F ILL I + AL P
Sbjct: 767 KEKAVPIPEAS----SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPI 822
Query: 116 PEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL 175
D N L+ + F +FTVE VLK+ YG LH ++ RN +N+LD ++V V L
Sbjct: 823 RADSMR--NQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSL 880
Query: 176 FSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALV 235
S+ LE VK LR RVLRPLR ++ L V+ + A+
Sbjct: 881 ISMGLESSAISV--------------VKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIS 926
Query: 236 PLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSG 287
+ +I L+ + ++A IG++LF G+ + C L E E +D P
Sbjct: 927 TIGNIVLVTTLLQFMFACIGVQLFKGKFFR-CTDLSKMTEEECRGYYYVYKDGDPM---- 981
Query: 288 SGRACTLNQTECRGR-WPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYE 346
Q E R R W + +FDN AM+++F T EGW +LY D+ +
Sbjct: 982 --------QIELRHREWVHSD---FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAED 1030
Query: 347 LPWVY---------FVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREK 394
+ +Y F+ +I +FF++N+ +G + F ++ E + K + +
Sbjct: 1031 VGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQ 1087
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 765 bits (1975), Expect = 0.0
Identities = 413/921 (44%), Positives = 587/921 (63%), Gaps = 69/921 (7%)
Query: 812 EEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHH 871
++EEE++EEEE++ G G PK P+P S+ F LS TNPLR+ CH +++
Sbjct: 1197 KKEEEKKEEEEDDRGEDG--------PK----PMPPYSSMFILSTTNPLRRLCHYILNLR 1244
Query: 872 VFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLH 931
F IL+ I +SS++LAAEDP++ ++ RN++L YFDY FT +FT E+++KM G LH
Sbjct: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLH 1304
Query: 932 RGSFCRSWFNMLDLLVVSVSLISFGIHSSA----ISVVKILRVLRVLRPLRAINRAKGLK 987
+G++ R +N+LD +VVS +L++F ++ I+ +K LRVLRVLRPL+ I R LK
Sbjct: 1305 QGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLK 1364
Query: 988 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVY 1047
V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C+G +L+Y
Sbjct: 1365 AVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLY 1424
Query: 1048 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIY 1107
+V R+R W +F++DNVL A++ LFTVST EGWP +L ++DA E+ GP
Sbjct: 1425 EKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSP 1481
Query: 1108 NYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKA 1167
YR+E+S+F++VY ++ FF +NIFV +IITF+ QG++ + L+KN+R C+++A+ A
Sbjct: 1482 GYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISA 1541
Query: 1168 QPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDIL 1225
+PL R++P+N QYR+W V S FEY + +I LNT+ L M+ Y + + A+ +
Sbjct: 1542 KPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVF 1601
Query: 1226 NMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSE 1285
N+VFT LF++E VLK++AF +YF DAWN FD + V+GSI DI VTE N
Sbjct: 1602 NIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN--------- 1652
Query: 1286 DSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIG 1345
+ I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAM+FFIYA+IG
Sbjct: 1653 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710
Query: 1346 MQMFGKVAL--------QDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNR 1397
MQ+FG + + +D QI +NNF+TF QA++LLFR ATGEAW IML+ L G
Sbjct: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770
Query: 1398 CDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1457
CD S E CG+ FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1771 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1827
Query: 1458 HLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1517
HLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHRVACKRL+ M++P+
Sbjct: 1828 HLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVAD 1887
Query: 1518 DGTVTFNATLFALVRTSLKIKTE---GNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPD 1574
D TV FN+TL AL+RT+L IK + +Q + ELR + IW + QK LD ++ P
Sbjct: 1888 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
Query: 1575 EEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQA 1634
++TVGK YA +I +Y+R+ + +K LQA +R QD P M Q
Sbjct: 1948 STDLTVGKIYAAMMIMEYYRQSKAKK----------------LQA-MREEQDRTPLMFQR 1990
Query: 1635 LTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFG 1694
+ + +EG G L+ A M + S + S V+ + + ++
Sbjct: 1991 M--EPPSPTQEGGPGQNALPSTQLDPGGALMAHE-SGLKESPSWVTQRAQEMFQKTGTWS 2047
Query: 1695 PSDDDRGTPTSSQPSVPQAGS 1715
P ++G PT S P + S
Sbjct: 2048 P---EQGPPTDMPNSQPNSQS 2065
Score = 614 bits (1584), Expect = e-175
Identities = 355/825 (43%), Positives = 472/825 (57%), Gaps = 82/825 (9%)
Query: 14 PSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQRSP---- 69
P+ G G G G+ G S G G G ++ Q + + AQR+
Sbjct: 9 PARYGGGGSGAAAGVVVG-------SGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMAL 61
Query: 70 --------------RALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPF 115
R+LF + N +R+ I EW PF+ +IL TI ANC+ L +
Sbjct: 62 YNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHL 121
Query: 116 PEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL 175
P+DD + L+ E F+ IF E +KI+A G H +Y+RNGWN++DF++V+ G+
Sbjct: 122 PDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI 181
Query: 176 FSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALV 235
+ + + FD++ LRA RVLRPL+LVSG+PSL +VL SIMKA++
Sbjct: 182 LATVGTE-----------------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMI 224
Query: 236 PLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLN 295
PLL I LL+ F I+I+AIIGLE ++G+ H TC+ G+D E P+PC + R C N
Sbjct: 225 PLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-N 283
Query: 296 QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSL 355
T+C+ W GPN GIT FDN FA+LTVFQC+TMEGWTD+LY DA G W+YF+ L
Sbjct: 284 GTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPL 343
Query: 356 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELD 415
+I GSFF+LNLVLGVLSGEF+KERE+ + R F K R +QQ+E +L GY++WI++AEE+
Sbjct: 344 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVI 403
Query: 416 MEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDT 475
+ + D E + G LR R+T S +D
Sbjct: 404 LAEDETD------------------GEQRHPFDGALR------RTTIKKSK------TDL 433
Query: 476 GSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAV 535
+ E + + + R K K + R +R RR VK+ A YW V
Sbjct: 434 LNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTV 493
Query: 536 LLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNR 595
L LV LNTL +A H+ QP WL+ YA + L LF EM +K+YGLG Y S FN
Sbjct: 494 LSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNC 553
Query: 596 FDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655
FDC V+ G I E + GISVLR +RLLRIFKVT++WASL NLV SLLNSMKS
Sbjct: 554 FDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKS 613
Query: 656 IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNV 715
I SLL LLFLFI++F+LLGMQLFGG+FNFD+ T + FDTFP A++TVFQILTGEDWN
Sbjct: 614 IISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNE 672
Query: 716 VMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGE 775
VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVDNLA+ T
Sbjct: 673 VMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT------- 724
Query: 776 KSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEE 820
K +++ N+ L KE E + A+M +E+++ ++
Sbjct: 725 KDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQK 769
Score = 139 bits (350), Expect = 3e-32
Identities = 107/361 (29%), Positives = 174/361 (48%), Gaps = 46/361 (12%)
Query: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
++F L+ NPLRR C I+ + F++ IL+ I + +AL P + N+ L
Sbjct: 1223 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYF 1280
Query: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
+YVF +FT E V+K++ GLVLH AY R+ WN+LDFI+V L +
Sbjct: 1281 DYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF---------- 1330
Query: 191 PHTGGKPGG--FDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVI 248
TG G +K+LR RVLRPL+ + +P L V + ++ +L + +I ++ + +
Sbjct: 1331 --TGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1388
Query: 249 IIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNG 308
I+A++ ++LF G+ F E++E C G+ + E + R
Sbjct: 1389 FIFAVVAVQLFKGK------FFHCTDESKEFEKDC----RGKYLLYEKNEVKARDREWKK 1438
Query: 309 GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIF 358
++DN +A+LT+F T EGW VL DA GY E+ Y V V+F
Sbjct: 1439 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1498
Query: 359 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMED 418
FFV N+ + ++ F ++ GD K E+ +E++ R +D+ A+ L
Sbjct: 1499 PFFFV-NIFVALIIITFQEQ-------GD--KMMEEYSLEKNERACIDFAISAKPLTRHM 1548
Query: 419 P 419
P
Sbjct: 1549 P 1549
Score = 124 bits (312), Expect = 7e-28
Identities = 152/713 (21%), Positives = 288/713 (40%), Gaps = 132/713 (18%)
Query: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKV---LLCL 571
+ V+R ++ + + +L + N + +A E H T + E + + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 572 FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627
F E +K+ LG +Y+ + +N D VV GIL T E + LR V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAV 197
Query: 628 RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---- 683
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 684 ---------------------------------FDQTHTKRSTFDTFPQALLTVFQILTG 710
++ + + FD A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 711 EDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAK 770
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEN 372
Query: 771 DKGGEK-SNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEE-------------- 815
+ K ++ + +E G + + K EE + D E+ +
Sbjct: 373 RRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTD 432
Query: 816 ----EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHH 871
EE E++ + + G + + K+ E S FF + +R ++
Sbjct: 433 LLNPEEAEDQLADIASVGSPFARASIKSAKL----ENSTFFHKKERR-MRFYIRRMVKTQ 487
Query: 872 VFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLH 931
F +L + L+++ +A + + L Y ++ F +F E+ +KM G
Sbjct: 488 AFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT--- 543
Query: 932 RGSFCRSWFNMLD--LLVVSVSLISFGIHSSAISV-VKILRVLRVLRPLRAINRAKGLKH 988
+ S FN D +++ S+ + + + S + +LR LR+LR + L++
Sbjct: 544 -RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRN 602
Query: 989 VVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYP 1048
+V + ++++I +++ + L +FA +G+QLF G+F DE TP
Sbjct: 603 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN--FDEG--TPPT--------- 649
Query: 1049 DGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYN 1108
NFD +A+M +F + T E W ++Y I + G +
Sbjct: 650 -------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMV- 689
Query: 1109 YRVEISVFFIVYIIIIAFFMMNIFVGFVI--------ITFRAQGEQEYQNCEL 1153
S++FIV + + ++N+F+ + +T Q E+E N +L
Sbjct: 690 ----FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 738
Score = 113 bits (283), Expect = 2e-24
Identities = 74/268 (27%), Positives = 134/268 (50%), Gaps = 29/268 (10%)
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
V + AF + + L+ LNT+ +A+ HY Q + + +F GLF EM +K+
Sbjct: 484 VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT 543
Query: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306
+ YF ++N FD +++GSI ++ + G G I+ R R++R+ K+
Sbjct: 544 RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG----------ISVLRALRLLRIFKV 593
Query: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNN 1365
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ +GT N
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PTN 650
Query: 1366 FQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFF 1425
F TFP A++ +F+ TGE W E+M + +S G G F+I YFI
Sbjct: 651 FDTFPAAIMTVFQILTGEDWNEVMYDGI-------KSQGG----VQGGMVFSI-YFIVLT 698
Query: 1426 MLCAFLIINLFVAVIMDNF---DYLTRD 1450
+ + ++N+F+A+ +DN LT+D
Sbjct: 699 LFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 106 bits (264), Expect = 3e-22
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 33/331 (9%)
Query: 850 AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYF 907
+ F S+ N +RK + F +IL II + + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 908 DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLIS-FGIHSSAISVVK 966
+ F IF E +K+ G H+GS+ R+ +N++D +VV +++ G ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 1027 Y-TCTDEAK-----HTPQEC--KGSFLVYPDGDVSRPLVRERLWV---NSDFNFDNVLSA 1075
+ TC +E +P C + P+G +P W N FDN+L A
Sbjct: 253 HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQP-----YWEGPNNGITQFDNILFA 307
Query: 1076 MMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGF 1135
++ +F T EGW LLY + DA G +N+ ++FI III +FFM+N+ +G
Sbjct: 308 VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
Query: 1136 VIITFRAQGEQ-EYQNCELDKNQRQCVEYAL 1165
+ F + E+ E + L ++Q +E L
Sbjct: 359 LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
Score = 100 bits (250), Expect = 1e-20
Identities = 78/301 (25%), Positives = 148/301 (49%), Gaps = 22/301 (7%)
Query: 480 ETQGDEDEEEGALASCTR-CLNKIMKTR-VCRRLRRANRVLRARCRRAVKSNACYWAVLL 537
+ QGD+ EE +L R C++ + + + R + + + + R + V S + ++
Sbjct: 1515 QEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMA 1574
Query: 538 LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597
++ LNT+ + + +G V N V LF++E +LK+ G Y +N FD
Sbjct: 1575 MIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD 1634
Query: 598 CFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIA 657
V G I + + E G + +S LR R R+ K+ R ++ L+ + + S K++
Sbjct: 1635 FVTVLGSITDILVTEFGN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1693
Query: 658 SLLLLLFLFIIIFSLLGMQLFGG------KFNFDQTH---TKRSTFDTFPQALLTVFQIL 708
+ LL+ + I++++GMQ+FG + D+ T+ + F TF QAL+ +F+
Sbjct: 1694 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1753
Query: 709 TGEDWNVVMYDGIMAYGGPFFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVD 759
TGE W+ +M + G+L YF+ +F+C ++++LN+F+A+ +D
Sbjct: 1754 TGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMD 1812
Query: 760 N 760
N
Sbjct: 1813 N 1813
Score = 87.8 bits (216), Expect = 9e-17
Identities = 98/424 (23%), Positives = 177/424 (41%), Gaps = 100/424 (23%)
Query: 96 ILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHP 155
+L L+ + CVA+ V+ PE S+ L E++FL +F E +K+ YGL P
Sbjct: 493 VLSLVALNTLCVAI-VHYNQPEWLSDF----LYYAEFIFLGLFMSEMFIKM--YGLGTRP 545
Query: 156 SAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG-GFDVKALRAFRVLRPL 214
Y + +N D +++ +F V+ KPG F + LRA R+LR
Sbjct: 546 --YFHSSFNCFDCGVIIGSIFEVIWAVI------------KPGTSFGISVLRALRLLRIF 591
Query: 215 RLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDM 274
++ SL ++ S++ ++ ++ + L+ I+++A++G++LF G
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF-----------GGQF 640
Query: 275 EAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTD 334
+E P TNFD F A++TVFQ +T E W +
Sbjct: 641 NFDEGTPP----------------------------TNFDTFPAAIMTVFQILTGEDWNE 672
Query: 335 VLY-------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGD 387
V+Y +Q M + +YF+ L +FG++ +LN+ L + + +E K
Sbjct: 673 VMYDGIKSQGGVQGGMVFS---IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK---- 725
Query: 388 FQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRR 447
+Q E++ + L + +A+E+ P + N+ +E + +P + R
Sbjct: 726 -DEQEEEEAANQKLA-----LQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQR- 778
Query: 448 RGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRV 507
+ R + +S +L + D +E A+ TR L MKT +
Sbjct: 779 -------TSEMRKQNLLASREAL-----------YNEMDPDERWKAAYTRHLRPDMKTHL 820
Query: 508 CRRL 511
R L
Sbjct: 821 DRPL 824
Score = 86.3 bits (212), Expect = 3e-16
Identities = 69/280 (24%), Positives = 126/280 (45%), Gaps = 40/280 (14%)
Query: 518 LRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQP-VWLTQIQEYANKVLLCLFTVEM 576
LR C + +L+++ ++++ +A+E QP + Y + V +FT EM
Sbjct: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1292
Query: 577 LLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLG-ISVLRCVRLLR 631
++K+ LG AY +N D VV G ++ + + I LR +R+LR
Sbjct: 1293 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1352
Query: 632 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR 691
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF +K
Sbjct: 1353 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1412
Query: 692 ST----------------------------FDTFPQALLTVFQILTGEDWNVVM---YDG 720
+D ALLT+F + TGE W V+ D
Sbjct: 1413 FEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA 1472
Query: 721 IMAYGGPFFPG--MLVCIYFIILFICGNYILLNVFLAIAV 758
GP PG M + I++++ F+ + +N+F+A+ +
Sbjct: 1473 TFENQGP-SPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1511
Score = 82.0 bits (201), Expect = 5e-15
Identities = 72/297 (24%), Positives = 130/297 (43%), Gaps = 63/297 (21%)
Query: 93 PFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV-EYVFLVIFTVETVLKIVAYGL 151
PF+ I+ I N + L + ++ A N +V VF +F++E VLK++A+G+
Sbjct: 1567 PFEYTIMAMIALNTIVLMMKFY----GASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1622
Query: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVL 211
+ Y R+ WN+ DF+ V+ + +L+ + ++ LR FR
Sbjct: 1623 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNN------------FINLSFLRLFRAA 1666
Query: 212 RPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG 271
R ++L+ ++ I+L + +++ L ++ LL+ + IYAIIG+++F +G
Sbjct: 1667 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN--------IG 1718
Query: 272 SDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEG 331
D+E E+ TE NF FF A++ +F+ T E
Sbjct: 1719 IDVEDEDSDED----------EFQITE-----------HNNFRTFFQALMLLFRSATGEA 1757
Query: 332 WTDVLY-------------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375
W +++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1758 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
Score = 73.2 bits (178), Expect = 2e-12
Identities = 66/296 (22%), Positives = 117/296 (39%), Gaps = 75/296 (25%)
Query: 1192 FEYLMFLLILLNTVALAMQHY---EQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----F 1244
FEY++ I+ N + LA++ + + P + +D F G+F E +KIIA F
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1245 KPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLV 1304
Y + WN D ++V+ I+ TE + + R RV+R +
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD----------------LRTLRAVRVLRPL 203
Query: 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQM----FGKVALQDGTQ- 1359
KL+S ++ +L + +K+ L + LL+ I+A+IG++ F ++GT
Sbjct: 204 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDD 263
Query: 1360 ----------------------------INRNNNFQTFPQ---AVLLLFRCATGEAWQEI 1388
NN F AVL +F+C T E W ++
Sbjct: 264 IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 323
Query: 1389 MLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+ S + G+ + YFI ++ +F ++NL + V+ F
Sbjct: 324 LYNSNDAS----------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 761 bits (1965), Expect = 0.0
Identities = 391/789 (49%), Positives = 534/789 (67%), Gaps = 26/789 (3%)
Query: 823 EEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFII 882
E + G E+ + V + PI S+ FCLS TN LR+ CH ++ F +ILV I
Sbjct: 1102 ESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIA 1161
Query: 883 LSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNM 942
LSS++LAAEDP+R S RN+ L Y DY FT +FT E+++KM G LH G++ R +N+
Sbjct: 1162 LSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNI 1221
Query: 943 LDLLVVSVSLISFGIHSSA---ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 999
LD +VVS +L++F S I+ +K LRVLRVLRPL+ I R LK V CV +++
Sbjct: 1222 LDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKN 1281
Query: 1000 IGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRE 1059
+ NI+IV L F+FA I VQLFKGKF+ CTDE+K ++C+G +L Y +V +
Sbjct: 1282 VLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVE---AQP 1338
Query: 1060 RLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIV 1119
R W DF++DNVL A++ LFTVST EGWP +L ++DA E+ GP YR+E+S+F++V
Sbjct: 1339 RQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVV 1398
Query: 1120 YIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPH 1179
Y ++ FF +NIFV +IITF+ QG++ C L+KN+R C+++A+ A+PL RY+P+N
Sbjct: 1399 YFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQ 1458
Query: 1180 --QYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEM 1237
QY+ W V S FEY + +I LNTV L M+ Y+ + + LN+VFT +F++E
Sbjct: 1459 SFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMEC 1518
Query: 1238 VLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRL 1297
VLKIIAF +YF DAWN FD + V+GSI DI VTE+ +E ++ I+++F RL
Sbjct: 1519 VLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI---------AETNNFINLSFLRL 1569
Query: 1298 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDG 1357
FR RL+KLL +G IR LLWTF++SF+ALPYV LLIAM+FFIYA+IGMQ+FG +AL D
Sbjct: 1570 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1629
Query: 1358 TQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFA 1417
T INR+NNF+TF QA++LLFR ATGEAW EIML+ L CD +++ CGS+FA
Sbjct: 1630 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQAN-----ATECGSDFA 1684
Query: 1418 IAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRI 1477
YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+W+EYDP A GRI
Sbjct: 1685 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRI 1744
Query: 1478 KHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPL-NSDGTVTFNATLFALVRTSLK 1536
+ D+ +L+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RT+L+
Sbjct: 1745 SYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALE 1804
Query: 1537 IK---TEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYF 1593
IK Q + ELR I +W + QK LD ++PP +E+TVGK YA +I D++
Sbjct: 1805 IKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFY 1864
Query: 1594 RKFRRRKEK 1602
++ + +++
Sbjct: 1865 KQNKTTRDQ 1873
Score = 603 bits (1554), Expect = e-172
Identities = 362/843 (42%), Positives = 476/843 (56%), Gaps = 67/843 (7%)
Query: 6 GGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVA-S 64
GG + GPGP GL PG + +S +R + + + V +
Sbjct: 16 GGGERARGGGAGGAGGPGPG-GLQPGQRVLYKQSIA-------QRARTMALYNPIPVKQN 67
Query: 65 AQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTAN 124
R+LF + N +R+ I EW PF+ +IL TI ANC+ L + P+ D +
Sbjct: 68 CFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMS 127
Query: 125 HNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGP 184
L+ E F+ IF E +KI+A G V H +Y+RNGWN++DF++V+ G+ +
Sbjct: 128 ERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA------- 180
Query: 185 GRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLV 244
T G FD++ LRA RVLRPL+LVSG+PSL +VL SIMKA+VPLL I LL+
Sbjct: 181 --------TAGTD--FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLL 230
Query: 245 LFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWP 304
F I+++AIIGLE ++G+ HK C+ +D E D PC R C TECR WP
Sbjct: 231 FFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCE-GDTECREYWP 288
Query: 305 GPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVL 364
GPN GITNFDN FA+LTVFQC+TMEGWTD+LY DA G W+YF+ L+I GSFF+L
Sbjct: 289 GPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFML 348
Query: 365 NLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDN 424
NLVLGVLSGEF+KERE+ + R F K R +QQ+E +L GYL+WI +AEE+
Sbjct: 349 NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEV---------- 398
Query: 425 LGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGD 484
+AEE R ++ R +T+ + + HA E D
Sbjct: 399 --MLAEEDRNAEEKSPLDVLKRA---------ATKKSRNDLIHA-----------EEGED 436
Query: 485 EDEEEGALAS-CTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNT 543
+ A+ S R K KT RR ++ R RR VK+ + YW VL +V LNT
Sbjct: 437 RFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNT 496
Query: 544 LTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCG 603
L +A H+ QP LT +A V L LF EM LK+YGLGP +Y S FN FD V+ G
Sbjct: 497 LCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVG 556
Query: 604 GILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLL 663
+ E + GISVLR +RLLRIFKVT++W+SL NLV SLLNSMKSI SLL LL
Sbjct: 557 SVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLL 616
Query: 664 FLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMA 723
FLFI++F+LLGMQLFGG+FNF Q T + FDTFP A+LTVFQILTGEDWN VMY GI +
Sbjct: 617 FLFIVVFALLGMQLFGGQFNF-QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 675
Query: 724 YGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKDLP 783
GG GM YFI+L + GNY LLNVFLAIAVDNLA+ T ++ E++ + L
Sbjct: 676 QGG-VSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLA 734
Query: 784 QENEGLVPGVEKEEEE----GARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPK 839
+ V V AR++ + E+ + + A L E+ P+
Sbjct: 735 LQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPE 794
Query: 840 EKV 842
E++
Sbjct: 795 ERL 797
Score = 144 bits (362), Expect = 1e-33
Identities = 101/330 (30%), Positives = 169/330 (51%), Gaps = 34/330 (10%)
Query: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
++FCL+ N LRR C IV + F+++IL+ I + +AL P D N+ L+ +
Sbjct: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYL 1186
Query: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
+Y+F +FT E V+K++ GL+LHP AY R+ WN+LDFI+V L + G+ +
Sbjct: 1187 DYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINT 1246
Query: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
+K+LR RVLRPL+ + +P L V + ++ +L +L+I ++ + + I
Sbjct: 1247 -----------IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFI 1295
Query: 251 YAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGI 310
+A+I ++LF G+ +F +D E++E C G+ + E +
Sbjct: 1296 FAVIAVQLFKGK-----FFYCTD-ESKELERDC----RGQYLDYEKEEVEAQPRQWKKYD 1345
Query: 311 TNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIFGS 360
++DN +A+LT+F T EGW VL DA GY EL Y V V+F
Sbjct: 1346 FHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPF 1405
Query: 361 FFVLNLVLGVLSGEFSKEREKAKARGDFQK 390
FFV N+ + ++ F ++ +K + +K
Sbjct: 1406 FFV-NIFVALIIITFQEQGDKVMSECSLEK 1434
Score = 124 bits (312), Expect = 7e-28
Identities = 150/690 (21%), Positives = 280/690 (40%), Gaps = 128/690 (18%)
Query: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHH---GQPVWLTQIQEYANKVLLCL 571
+ V+R +R + + +L + N + +A E H G +++ + + +
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 572 FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627
F E +K+ LG +Y+ + +N D VV GIL T A + LR V
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILAT------AGTDFDLRTLRAV 194
Query: 628 RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF--- 684
R+LR K+ SL ++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 195 RVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF 254
Query: 685 ------------------------DQTHTKR---------STFDTFPQALLTVFQILTGE 711
T + + FD A+LTVFQ +T E
Sbjct: 255 PNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITME 314
Query: 712 DWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKD 771
W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 315 GWTDILYNTNDAAGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENR 369
Query: 772 KGGEK-SNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEE--------------- 815
+ K ++ + +E G + + K EE E + EE+ +
Sbjct: 370 RAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLI 429
Query: 816 --EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVF 873
EE E+ + A G + + K E S++F + R ++ F
Sbjct: 430 HAEEGEDRFADLCAVGSPFARASLKSGKT----ESSSYFRRKE-KMFRFFIRRMVKAQSF 484
Query: 874 TNLILVFIILSSVSLAA---EDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFL 930
++L + L+++ +A P R + L + ++ F +F E+ LKM G
Sbjct: 485 YWVVLCVVALNTLCVAMVHYNQPRRLTT----TLYFAEFVFLGLFLTEMSLKMYGLGP-- 538
Query: 931 HRGSFCRSWFNMLDLLVVSVSLISF---GIHSSAISVVKILRVLRVLRPLRAINRAKGLK 987
S+ RS FN D V+ S+ I + + +LR LR+LR + L+
Sbjct: 539 --RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLR 596
Query: 988 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVY 1047
++V + ++++I +++ + L +FA +G+QLF G+F DE T
Sbjct: 597 NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT----------- 644
Query: 1048 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIY 1107
NFD +A++ +F + T E W A++Y I++ ++
Sbjct: 645 --------------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMF 684
Query: 1108 NYRVEISVFFIVYIIIIAFFMMNIFVGFVI 1137
+ S +FIV + + ++N+F+ +
Sbjct: 685 S-----SFYFIVLTLFGNYTLLNVFLAIAV 709
Score = 124 bits (311), Expect = 9e-28
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 29/268 (10%)
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
V + +F +++ ++ LNT+ +AM HY Q + VF GLF EM LK+ P
Sbjct: 479 VKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP 538
Query: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306
+ YF ++N FD ++VGS+ ++ + G G I+ R R++R+ K+
Sbjct: 539 RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFG----------ISVLRALRLLRIFKV 588
Query: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNN 1365
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ QD T N
Sbjct: 589 TKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP---TTN 645
Query: 1366 FQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFF 1425
F TFP A+L +F+ TGE W +M + ES G + F+ YFI
Sbjct: 646 FDTFPAAILTVFQILTGEDWNAVMYHGI-------ESQGGVSK-----GMFSSFYFIVLT 693
Query: 1426 MLCAFLIINLFVAVIMDNF---DYLTRD 1450
+ + ++N+F+A+ +DN LT+D
Sbjct: 694 LFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 108 bits (270), Expect = 5e-23
Identities = 102/370 (27%), Positives = 172/370 (46%), Gaps = 47/370 (12%)
Query: 826 GAGGVELLQEVVPKEKVV----------PIPE-------GSAFFCLSQTNPLRKGCHTLI 868
G GG++ Q V+ K+ + PIP + F S+ N +RK +
Sbjct: 33 GPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRIT 92
Query: 869 HHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
F +IL II + + LA E P + + L + F IF E +K+
Sbjct: 93 EWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIAL 152
Query: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGL 986
G H+GS+ R+ +N++D +VV +++ + ++ LR +RVLRPL+ ++ L
Sbjct: 153 GFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 987 KHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TCTDEAKHTPQECKGSFL 1045
+ V++ + A+ + I ++ MFA IG++ + GKF+ C + T E G F
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS--TDAEPVGDF- 266
Query: 1046 VYPDGDVSRPLVRE------RLWVNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAI 1096
P G + + E W +F NFDN+L A++ +F T EGW +LY
Sbjct: 267 --PCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTN 324
Query: 1097 DAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQ-EYQNCELDK 1155
DA G +N+ ++FI III +FFM+N+ +G + F + E+ E + L
Sbjct: 325 DA----AGNTWNW-----LYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKL 375
Query: 1156 NQRQCVEYAL 1165
++Q +E L
Sbjct: 376 RRQQQIEREL 385
Score = 101 bits (251), Expect = 8e-21
Identities = 75/292 (25%), Positives = 141/292 (48%), Gaps = 12/292 (4%)
Query: 480 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANRV-LRARCRRAVKSNACYWAVLL 537
+ QGD+ E +L R C++ + + R NR + + V S + ++
Sbjct: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
Query: 538 LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597
++ LNT+ + + + P + + N V +F++E +LK+ G Y +N FD
Sbjct: 1480 MIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD 1539
Query: 598 CFVVCGGILETTLVEVGAMQP-LGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSI 656
V G I + + E+ + +S LR R R+ K+ R ++ L+ + + S K++
Sbjct: 1540 FVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKAL 1599
Query: 657 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWNV 715
+ LL+ + I++++GMQ+FG D T R + F TF QAL+ +F+ TGE W+
Sbjct: 1600 PYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHE 1659
Query: 716 VMYDGIMAYGGPFFPGMLVC------IYFI-ILFICGNYILLNVFLAIAVDN 760
+M + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1660 IMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 89.0 bits (219), Expect = 4e-17
Identities = 71/283 (25%), Positives = 129/283 (45%), Gaps = 45/283 (15%)
Query: 517 VLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQ----EYANKVLLCLF 572
+LR C V +L+++ L+++ +A+E PV + +Y + + +F
Sbjct: 1138 LLRRFCHYIVTMRYFEVVILVVIALSSIALAAE---DPVRTDSPRNNALKYLDYIFTGVF 1194
Query: 573 TVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVR 628
T EM++K+ LG P AY +N D VV G ++ I LR +R
Sbjct: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
Query: 629 LLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTH 688
+LR K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF +
Sbjct: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDE 1314
Query: 689 TKRST----------------------------FDTFPQALLTVFQILTGEDWNVVM--- 717
+K +D ALLT+F + TGE W +V+
Sbjct: 1315 SKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHS 1374
Query: 718 YDGIMAYGGPFFPG--MLVCIYFIILFICGNYILLNVFLAIAV 758
D GP PG M + I++++ F+ + +N+F+A+ +
Sbjct: 1375 VDATYEEQGP-SPGYRMELSIFYVVYFVVFPFFFVNIFVALII 1416
Score = 78.2 bits (191), Expect = 7e-14
Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 77/346 (22%)
Query: 53 QHSKHKTVAVASAQRSPRALFC-------LTLANPLRRSCISIVEWK-----PFDILILL 100
Q K ++ S +++ RA LT P R W PF+ I+
Sbjct: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
Query: 101 TIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIR 160
I N V L + D L+ + VF +F++E VLKI+A+G++ Y R
Sbjct: 1480 MIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL----NYFR 1532
Query: 161 NGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGV 220
+ WN+ DF+ V+ + +L+ + ++ LR FR R ++L+
Sbjct: 1533 DAWNVFDFVTVLGSITDILVTE----------IAETNNFINLSFLRLFRAARLIKLLRQG 1582
Query: 221 PSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDP 280
++ I+L + +++ L ++ LL+ + IYAIIG+++F ++ ++D
Sbjct: 1583 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------GNIALDDDT 1630
Query: 281 SPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWM- 339
S +N+ NF F A++ +F+ T E W +++
Sbjct: 1631 S------------INRH-------------NNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Query: 340 ----------QDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375
G + + YFVS + SF +LNL + V+ F
Sbjct: 1666 SNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 71.2 bits (173), Expect = 9e-12
Identities = 68/295 (23%), Positives = 118/295 (40%), Gaps = 74/295 (25%)
Query: 1192 FEYLMFLLILLNTVALAMQHY---EQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----F 1244
FEY++ I+ N + LA++ + P + +D F G+F E +KIIA F
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1245 KPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLV 1304
Y + WN D ++V+ I+ A T+ + R RV+R +
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTD----------------FDLRTLRAVRVLRPL 200
Query: 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF--------------- 1349
KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
Query: 1350 --------GKVA---LQDGTQINRN---------NNFQTFPQAVLLLFRCATGEAWQEIM 1389
GK A L +G R NF A+L +F+C T E W +I+
Sbjct: 261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query: 1390 LASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
N D G+ + YFI ++ +F ++NL + V+ F
Sbjct: 321 Y-----NTND-----------AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 756 bits (1953), Expect = 0.0
Identities = 409/921 (44%), Positives = 585/921 (63%), Gaps = 69/921 (7%)
Query: 812 EEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHH 871
++EEE++EEEE++ G G PK P+P S+ F LS TNPLR+ CH +++
Sbjct: 1196 KKEEEKKEEEEDDRGEDG--------PK----PMPPYSSMFILSTTNPLRRLCHYILNLR 1243
Query: 872 VFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLH 931
F IL+ I +SS++LAAEDP++ ++ RN++L YFDY FT +FT E+++KM G LH
Sbjct: 1244 YFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLH 1303
Query: 932 RGSFCRSWFNMLDLLVVSVSLISFGIHSSA----ISVVKILRVLRVLRPLRAINRAKGLK 987
+G++ R +N+LD +VVS +L++F ++ I+ +K LRVLRVLRPL+ I R LK
Sbjct: 1304 QGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLK 1363
Query: 988 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVY 1047
V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C+G +L+Y
Sbjct: 1364 AVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLY 1423
Query: 1048 PDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIY 1107
+V R+R W +F++DNVL A++ LFTVST EGWP +L ++DA E+ GP
Sbjct: 1424 EKNEVK---ARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSP 1480
Query: 1108 NYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKA 1167
YR+E+S+F++VY ++ FF +NIFV +IITF+ QG++ + L+KN+R C+++A+ A
Sbjct: 1481 GYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISA 1540
Query: 1168 QPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDIL 1225
+PL R++P+N QYR+W V S FEY + +I LNT+ L M+ Y + + A+ +
Sbjct: 1541 KPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVF 1600
Query: 1226 NMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSE 1285
N+VFT LF++E VLK++AF +YF DAWN FD + V+GSI DI VTE N
Sbjct: 1601 NIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN--------- 1651
Query: 1286 DSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIG 1345
+ I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LLIAM+FFIYA+IG
Sbjct: 1652 --NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1709
Query: 1346 MQMFGKVAL--------QDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNR 1397
MQ+FG + + +D QI +NNF+TF QA++LLFR ATGEAW IML+ L G
Sbjct: 1710 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1769
Query: 1398 CDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1457
CD S E CG+ FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SILGPH
Sbjct: 1770 CDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1826
Query: 1458 HLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1517
HLDE+ R+W+EYDP A GR+ +LD+ +LR + PPLG GK CP RVA KRL+ M++P+
Sbjct: 1827 HLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVAD 1886
Query: 1518 DGTVTFNATLFALVRTSLKIKTE---GNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPD 1574
D TV FN+TL AL+RT+L IK + +Q + ELR + IW + QK LD ++ P
Sbjct: 1887 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1946
Query: 1575 EEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQA 1634
++TVGK YA +I +Y+R+ + +K LQA +R QD P M Q
Sbjct: 1947 STDLTVGKIYAAMMIMEYYRQSKAKK----------------LQA-MREEQDRTPLMFQR 1989
Query: 1635 LTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFG 1694
+ + +EG G L+ A M + S + S V+ + + ++
Sbjct: 1990 M--EPPSPTQEGGPGQNALPSTQLDPGGALMAHE-SGLKESPSWVTQRAQEMFQKTGTWS 2046
Query: 1695 PSDDDRGTPTSSQPSVPQAGS 1715
P ++G PT S P + S
Sbjct: 2047 P---EQGPPTDMPNSQPNSQS 2064
Score = 614 bits (1583), Expect = e-175
Identities = 354/825 (42%), Positives = 470/825 (56%), Gaps = 83/825 (10%)
Query: 14 PSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQRSP---- 69
P+ G G G G+ G S G G G ++ Q + + AQR+
Sbjct: 9 PARYGGGGSGAAAGVVVG-------SGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMAL 61
Query: 70 --------------RALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPF 115
R+LF + N +R+ I EW PF+ +IL TI ANC+ L +
Sbjct: 62 YNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHL 121
Query: 116 PEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL 175
P+DD + L+ E F+ IF E +KI+A G H +Y+RNGWN++DF++V+ G+
Sbjct: 122 PDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI 181
Query: 176 FSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALV 235
+ + + FD++ LRA RVLRPL+LVSG+PSL +VL SIMKA++
Sbjct: 182 LATVGTE-----------------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMI 224
Query: 236 PLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLN 295
PLL I LL+ F I+I+AIIGLE ++G+ H TC+ G+D E P+PC + R C N
Sbjct: 225 PLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-N 283
Query: 296 QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSL 355
T+C+ W GPN GIT FDN FA+LTVFQC+TMEGWTD+LY DA G W+YF+ L
Sbjct: 284 GTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPL 343
Query: 356 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELD 415
+I GSFF+LNLVLGVLSGEF+KERE+ + R F K R +QQ+E +L GY++WI++AEE+
Sbjct: 344 IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVI 403
Query: 416 MEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDT 475
+ + D G H F R+T S +D
Sbjct: 404 LAEDETD---------GEQRHP----------------FDALRRTTIKKSK------TDL 432
Query: 476 GSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAV 535
+ E + + + R K K + R +R RR VK+ A YW V
Sbjct: 433 LNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTV 492
Query: 536 LLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNR 595
L LV LNTL +A H+ QP WL+ YA + L LF EM +K+YGLG Y S FN
Sbjct: 493 LSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNC 552
Query: 596 FDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655
FDC V+ G I E + GISVLR +RLLRIFKVT++WASL NLV SLLNSMKS
Sbjct: 553 FDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKS 612
Query: 656 IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNV 715
I SLL LLFLFI++F+LLGMQLFGG+FNFD+ T + FDTFP A++TVFQILTGEDWN
Sbjct: 613 IISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTPPTNFDTFPAAIMTVFQILTGEDWNE 671
Query: 716 VMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGE 775
VMYDGI + GG GM+ IYFI+L + GNY LLNVFLAIAVDNLA+ T
Sbjct: 672 VMYDGIKSQGG-VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT------- 723
Query: 776 KSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEE 820
K +++ N+ L KE E + A+M +E+++ ++
Sbjct: 724 KDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQK 768
Score = 139 bits (350), Expect = 3e-32
Identities = 107/361 (29%), Positives = 174/361 (48%), Gaps = 46/361 (12%)
Query: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
++F L+ NPLRR C I+ + F++ IL+ I + +AL P + N+ L
Sbjct: 1222 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYF 1279
Query: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
+YVF +FT E V+K++ GLVLH AY R+ WN+LDFI+V L +
Sbjct: 1280 DYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF---------- 1329
Query: 191 PHTGGKPGG--FDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVI 248
TG G +K+LR RVLRPL+ + +P L V + ++ +L + +I ++ + +
Sbjct: 1330 --TGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1387
Query: 249 IIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNG 308
I+A++ ++LF G+ F E++E C G+ + E + R
Sbjct: 1388 FIFAVVAVQLFKGK------FFHCTDESKEFEKDC----RGKYLLYEKNEVKARDREWKK 1437
Query: 309 GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAM--------GY--ELPWVYFVSLVIF 358
++DN +A+LT+F T EGW VL DA GY E+ Y V V+F
Sbjct: 1438 YEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF 1497
Query: 359 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMED 418
FFV N+ + ++ F ++ GD K E+ +E++ R +D+ A+ L
Sbjct: 1498 PFFFV-NIFVALIIITFQEQ-------GD--KMMEEYSLEKNERACIDFAISAKPLTRHM 1547
Query: 419 P 419
P
Sbjct: 1548 P 1548
Score = 125 bits (313), Expect = 5e-28
Identities = 152/712 (21%), Positives = 288/712 (40%), Gaps = 131/712 (18%)
Query: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKV---LLCL 571
+ V+R ++ + + +L + N + +A E H T + E + + +
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 572 FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627
F E +K+ LG +Y+ + +N D VV GIL T E + LR V
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------FDLRTLRAV 197
Query: 628 RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---- 683
R+LR K+ SL ++ S++ +M + + LLLF I+IF+++G++ + GKF+
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 684 ---------------------------------FDQTHTKRSTFDTFPQALLTVFQILTG 710
++ + + FD A+LTVFQ +T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM 317
Query: 711 EDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAK 770
E W ++Y+ A G + +YFI L I G++ +LN+ L + A
Sbjct: 318 EGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEN 372
Query: 771 DKGGEK-SNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEE-------------- 815
+ K ++ + +E G + + K EE + D E+ +
Sbjct: 373 RRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDALRRTTIKKSKTDL 432
Query: 816 ---EEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHV 872
EE E++ + + G + + K+ E S FF + +R ++
Sbjct: 433 LNPEEAEDQLADIASVGSPFARASIKSAKL----ENSTFFHKKERR-MRFYIRRMVKTQA 487
Query: 873 FTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHR 932
F +L + L+++ +A + + L Y ++ F +F E+ +KM G
Sbjct: 488 FYWTVLSLVALNTLCVAIVH-YNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT---- 542
Query: 933 GSFCRSWFNMLD--LLVVSVSLISFGIHSSAISV-VKILRVLRVLRPLRAINRAKGLKHV 989
+ S FN D +++ S+ + + + S + +LR LR+LR + L+++
Sbjct: 543 RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNL 602
Query: 990 VQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPD 1049
V + ++++I +++ + L +FA +G+QLF G+F DE TP
Sbjct: 603 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN--FDEG--TPPT---------- 648
Query: 1050 GDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNY 1109
NFD +A+M +F + T E W ++Y I + G +
Sbjct: 649 ------------------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMV-- 688
Query: 1110 RVEISVFFIVYIIIIAFFMMNIFVGFVI--------ITFRAQGEQEYQNCEL 1153
S++FIV + + ++N+F+ + +T Q E+E N +L
Sbjct: 689 ---FSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 737
Score = 113 bits (283), Expect = 2e-24
Identities = 74/268 (27%), Positives = 134/268 (50%), Gaps = 29/268 (10%)
Query: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
V + AF + + L+ LNT+ +A+ HY Q + + +F GLF EM +K+
Sbjct: 483 VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGT 542
Query: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306
+ YF ++N FD +++GSI ++ + G G I+ R R++R+ K+
Sbjct: 543 RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG----------ISVLRALRLLRIFKV 592
Query: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNN 1365
+R L+ + + S +++ + L+ + ++A++GMQ+F G+ +GT N
Sbjct: 593 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP---PTN 649
Query: 1366 FQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFF 1425
F TFP A++ +F+ TGE W E+M + +S G G F+I YFI
Sbjct: 650 FDTFPAAIMTVFQILTGEDWNEVMYDGI-------KSQGG----VQGGMVFSI-YFIVLT 697
Query: 1426 MLCAFLIINLFVAVIMDNF---DYLTRD 1450
+ + ++N+F+A+ +DN LT+D
Sbjct: 698 LFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 106 bits (264), Expect = 3e-22
Identities = 93/331 (28%), Positives = 159/331 (48%), Gaps = 33/331 (9%)
Query: 850 AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYF 907
+ F S+ N +RK + F +IL II + + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 908 DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLIS-FGIHSSAISVVK 966
+ F IF E +K+ G H+GS+ R+ +N++D +VV +++ G ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 1027 Y-TCTDEAK-----HTPQEC--KGSFLVYPDGDVSRPLVRERLWV---NSDFNFDNVLSA 1075
+ TC +E +P C + P+G +P W N FDN+L A
Sbjct: 253 HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQP-----YWEGPNNGITQFDNILFA 307
Query: 1076 MMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGF 1135
++ +F T EGW LLY + DA G +N+ ++FI III +FFM+N+ +G
Sbjct: 308 VLTVFQCITMEGWTDLLYNSNDA----SGNTWNW-----LYFIPLIIIGSFFMLNLVLGV 358
Query: 1136 VIITFRAQGEQ-EYQNCELDKNQRQCVEYAL 1165
+ F + E+ E + L ++Q +E L
Sbjct: 359 LSGEFAKERERVENRRAFLKLRRQQQIEREL 389
Score = 100 bits (250), Expect = 1e-20
Identities = 78/301 (25%), Positives = 148/301 (49%), Gaps = 22/301 (7%)
Query: 480 ETQGDEDEEEGALASCTR-CLNKIMKTR-VCRRLRRANRVLRARCRRAVKSNACYWAVLL 537
+ QGD+ EE +L R C++ + + + R + + + + R + V S + ++
Sbjct: 1514 QEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMA 1573
Query: 538 LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597
++ LNT+ + + +G V N V LF++E +LK+ G Y +N FD
Sbjct: 1574 MIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD 1633
Query: 598 CFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIA 657
V G I + + E G + +S LR R R+ K+ R ++ L+ + + S K++
Sbjct: 1634 FVTVLGSITDILVTEFGN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1692
Query: 658 SLLLLLFLFIIIFSLLGMQLFGG------KFNFDQTH---TKRSTFDTFPQALLTVFQIL 708
+ LL+ + I++++GMQ+FG + D+ T+ + F TF QAL+ +F+
Sbjct: 1693 YVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSA 1752
Query: 709 TGEDWNVVMYDGIMAYGGPFFPGML--------VCIYFI-ILFICGNYILLNVFLAIAVD 759
TGE W+ +M + G+L YF+ +F+C ++++LN+F+A+ +D
Sbjct: 1753 TGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMD 1811
Query: 760 N 760
N
Sbjct: 1812 N 1812
Score = 87.8 bits (216), Expect = 9e-17
Identities = 98/424 (23%), Positives = 177/424 (41%), Gaps = 100/424 (23%)
Query: 96 ILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHP 155
+L L+ + CVA+ V+ PE S+ L E++FL +F E +K+ YGL P
Sbjct: 492 VLSLVALNTLCVAI-VHYNQPEWLSDF----LYYAEFIFLGLFMSEMFIKM--YGLGTRP 544
Query: 156 SAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG-GFDVKALRAFRVLRPL 214
Y + +N D +++ +F V+ KPG F + LRA R+LR
Sbjct: 545 --YFHSSFNCFDCGVIIGSIFEVIWAVI------------KPGTSFGISVLRALRLLRIF 590
Query: 215 RLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDM 274
++ SL ++ S++ ++ ++ + L+ I+++A++G++LF G
Sbjct: 591 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF-----------GGQF 639
Query: 275 EAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTD 334
+E P TNFD F A++TVFQ +T E W +
Sbjct: 640 NFDEGTPP----------------------------TNFDTFPAAIMTVFQILTGEDWNE 671
Query: 335 VLY-------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGD 387
V+Y +Q M + +YF+ L +FG++ +LN+ L + + +E K
Sbjct: 672 VMYDGIKSQGGVQGGMVFS---IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK---- 724
Query: 388 FQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRR 447
+Q E++ + L + +A+E+ P + N+ +E + +P + R
Sbjct: 725 -DEQEEEEAANQKLA-----LQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQR- 777
Query: 448 RGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRV 507
+ R + +S +L + D +E A+ TR L MKT +
Sbjct: 778 -------TSEMRKQNLLASREAL-----------YNEMDPDERWKAAYTRHLRPDMKTHL 819
Query: 508 CRRL 511
R L
Sbjct: 820 DRPL 823
Score = 86.3 bits (212), Expect = 3e-16
Identities = 69/280 (24%), Positives = 126/280 (45%), Gaps = 40/280 (14%)
Query: 518 LRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQP-VWLTQIQEYANKVLLCLFTVEM 576
LR C + +L+++ ++++ +A+E QP + Y + V +FT EM
Sbjct: 1232 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1291
Query: 577 LLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLG-ISVLRCVRLLR 631
++K+ LG AY +N D VV G ++ + + I LR +R+LR
Sbjct: 1292 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1351
Query: 632 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR 691
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF +K
Sbjct: 1352 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1411
Query: 692 ST----------------------------FDTFPQALLTVFQILTGEDWNVVM---YDG 720
+D ALLT+F + TGE W V+ D
Sbjct: 1412 FEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA 1471
Query: 721 IMAYGGPFFPG--MLVCIYFIILFICGNYILLNVFLAIAV 758
GP PG M + I++++ F+ + +N+F+A+ +
Sbjct: 1472 TFENQGP-SPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1510
Score = 82.0 bits (201), Expect = 5e-15
Identities = 72/297 (24%), Positives = 130/297 (43%), Gaps = 63/297 (21%)
Query: 93 PFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV-EYVFLVIFTVETVLKIVAYGL 151
PF+ I+ I N + L + ++ A N +V VF +F++E VLK++A+G+
Sbjct: 1566 PFEYTIMAMIALNTIVLMMKFY----GASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1621
Query: 152 VLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVL 211
+ Y R+ WN+ DF+ V+ + +L+ + ++ LR FR
Sbjct: 1622 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNN------------FINLSFLRLFRAA 1665
Query: 212 RPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLG 271
R ++L+ ++ I+L + +++ L ++ LL+ + IYAIIG+++F +G
Sbjct: 1666 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN--------IG 1717
Query: 272 SDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEG 331
D+E E+ TE NF FF A++ +F+ T E
Sbjct: 1718 IDVEDEDSDED----------EFQITE-----------HNNFRTFFQALMLLFRSATGEA 1756
Query: 332 WTDVLY-------------WMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375
W +++ + G E + YFVS + SF +LNL + V+ F
Sbjct: 1757 WHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
Score = 73.2 bits (178), Expect = 2e-12
Identities = 66/296 (22%), Positives = 117/296 (39%), Gaps = 75/296 (25%)
Query: 1192 FEYLMFLLILLNTVALAMQHY---EQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----F 1244
FEY++ I+ N + LA++ + + P + +D F G+F E +KIIA F
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1245 KPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLV 1304
Y + WN D ++V+ I+ TE + + R RV+R +
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD----------------LRTLRAVRVLRPL 203
Query: 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQM----FGKVALQDGTQ- 1359
KL+S ++ +L + +K+ L + LL+ I+A+IG++ F ++GT
Sbjct: 204 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDD 263
Query: 1360 ----------------------------INRNNNFQTFPQ---AVLLLFRCATGEAWQEI 1388
NN F AVL +F+C T E W ++
Sbjct: 264 IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 323
Query: 1389 MLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
+ S + G+ + YFI ++ +F ++NL + V+ F
Sbjct: 324 LYNSNDAS----------------GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 363
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 736 bits (1899), Expect = 0.0
Identities = 374/822 (45%), Positives = 546/822 (66%), Gaps = 39/822 (4%)
Query: 795 KEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCL 854
K + E + + A++ E+EEE E++++++E+ G + +VP S+ F
Sbjct: 1091 KTDGEASPLKEAEIREDEEEVEKKKQKKEKRETG-----KAMVPH---------SSMFIF 1136
Query: 855 SQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSI 914
S TNP+R+ CH +++ F IL+ I SS++LAAEDP+ +S RN +L YFDY FT +
Sbjct: 1137 STTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGV 1196
Query: 915 FTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSA-------ISVVKI 967
FT E+++KM G L GS+ R +N+LD +VV +L++F + ++ I +K
Sbjct: 1197 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKS 1256
Query: 968 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1027
LRVLRVLRPL+ I R LK V CV +++ + NI+IV L F+FA I VQLFKGKF+
Sbjct: 1257 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1316
Query: 1028 TCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEG 1087
CTD +K T +EC G+ Y D + ++ V+ R W +F++DN++ A++ LFTVST EG
Sbjct: 1317 YCTDSSKDTEKECIGN---YVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEG 1373
Query: 1088 WPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQE 1147
WP +L ++D ED GP + R+E+S+F++VY ++ FF +NIFV +IITF+ QG++
Sbjct: 1374 WPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKM 1433
Query: 1148 YQNCELDKNQRQCVEYALKAQPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLLILLNTV 1205
+ C L+KN+R C+++A+ A+PL RY+P+N H QYRVW V S +FEY + +I LNTV
Sbjct: 1434 MEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTV 1493
Query: 1206 ALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGS 1265
L M++Y + A+ LN+ FT +F++E VLK+IAF +YF D WN FD + V+GS
Sbjct: 1494 VLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGS 1553
Query: 1266 IVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQ 1325
I +I +T+ ++S +++F +LFR RL+KLL +G IR LLWTF++SF+
Sbjct: 1554 ITEIILTD--------SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFK 1605
Query: 1326 ALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAW 1385
ALPYV LLIAM+FFIYA+IGMQ+FG + L + + INR+NNF++F +++LLFR ATGEAW
Sbjct: 1606 ALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAW 1665
Query: 1386 QEIMLASLPGNRCDPESDF--GPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDN 1443
QEIML+ L C+P++ G E CG++ A YF+SF C+FL++NLFVAVIMDN
Sbjct: 1666 QEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
Query: 1444 FDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRV 1503
F+YLTRD SILGPHHLDEF R+W+EYD A GRI + ++ +L + PPLG GK CP +V
Sbjct: 1726 FEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKV 1785
Query: 1504 ACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE---GNLEQANQELRIVIKKIWKR 1560
A KRLV MNMP+ D TV F +TL AL+RT+L IK + +Q + EL+ IW
Sbjct: 1786 AYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPH 1845
Query: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEK 1602
+ QK+LD ++P P ++TVGK YA +I DY+++ + +K++
Sbjct: 1846 LSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
Score = 585 bits (1507), Expect = e-166
Identities = 343/757 (45%), Positives = 442/757 (58%), Gaps = 63/757 (8%)
Query: 70 RALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQ 129
R+LF N +R+ +++W PF+ +IL TI ANC+ L + PEDD + LE+
Sbjct: 67 RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEK 126
Query: 130 VEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGD 189
E F+ IF E +KIVA G + H +Y+RNGWN++DFI+V+ G+ + G
Sbjct: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATA--------GT 178
Query: 190 APHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVII 249
+T D++ LRA RVLRPL+LVSG+PSL IVL SIMKA+VPLL I LL+ F I+
Sbjct: 179 HFNTH-----VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAIL 233
Query: 250 IYAIIGLELFLGRMHKTCYFLGSD-MEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNG 308
++AIIGLE + G++H+ C+ S +E + P PC G C EC+ W GPN
Sbjct: 234 MFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGY-ECKD-WIGPND 287
Query: 309 GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL 368
GIT FDN FA+LTVFQC+TMEGWT VLY DA+G W+YF+ L+I GSFFVLNLVL
Sbjct: 288 GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVL 347
Query: 369 GVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSM 428
GVLSGEF+KERE+ + R F K R +QQ+E +L GY WI +AEE+ +
Sbjct: 348 GVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEV------------ML 395
Query: 429 AEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDED-- 486
AEE + ++ S A++ S T +MT DE
Sbjct: 396 AEENK----------------------NAGTSALEVLRRATIKRSRTEAMTRDSSDEHCV 433
Query: 487 EEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTI 546
+ R K K R R+LR R VKS YW VL LV LNT +
Sbjct: 434 DISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACV 493
Query: 547 ASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGIL 606
A HH QP WLT + YA + L LF +EM LK+YG+GP Y S FN FD V G I
Sbjct: 494 AIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIF 553
Query: 607 ETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLF 666
E GISVLR +RLLRIFK+T++WASL NLV SL++SMKSI SLL LLFLF
Sbjct: 554 EVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLF 613
Query: 667 IIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGG 726
I++F+LLGMQLFGG+FNF+ T + FDTFP A++TVFQILTGEDWN VMY+GI + GG
Sbjct: 614 IVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG 672
Query: 727 PFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKS-NEKDLPQE 785
GM IYFI+L + GNY LLNVFLAIAVDNLA+ T ++ E++ N+K Q+
Sbjct: 673 -VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQK 731
Query: 786 NEGL----VPGVEKEEEEGARREGADMEEEEEEEEEE 818
+ + P + E + RR M E E
Sbjct: 732 AKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRE 768
Score = 137 bits (345), Expect = 1e-31
Identities = 156/718 (21%), Positives = 297/718 (41%), Gaps = 116/718 (16%)
Query: 515 NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHH---GQPVWLTQIQEYANKVLLCL 571
+ ++R ++ + + +L + N + +A E H +++ E + +
Sbjct: 75 DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
Query: 572 FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627
F E +K+ LG +Y+ + +N D VV GIL T + + LR V
Sbjct: 135 FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH--VDLRTLRAV 192
Query: 628 RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---- 683
R+LR K+ SL ++ S++ +M + + LLLF I++F+++G++ + GK +
Sbjct: 193 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACF 252
Query: 684 ---------FDQTHTKR--------------------STFDTFPQALLTVFQILTGEDWN 714
FD H + FD A+LTVFQ +T E W
Sbjct: 253 MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
Query: 715 VVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGG 774
V+Y+ A G + +YFI L I G++ +LN+ L + A +
Sbjct: 313 TVLYNTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAF 367
Query: 775 EK-SNEKDLPQENEGLVPGVEKEEE----EGARREGADMEE------------EEEEEEE 817
K ++ + +E G ++K EE E + G E E +
Sbjct: 368 MKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDS 427
Query: 818 EEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLI 877
+E + + G L + + KV +G ++F + LR ++ VF ++
Sbjct: 428 SDEHCVDISSVGTPLARASIKSAKV----DGVSYF-RHKERLLRISIRHMVKSQVFYWIV 482
Query: 878 LVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCR 937
L + L++ +A + + H+L Y ++ F +F +E+ LKM G L +
Sbjct: 483 LSLVALNTACVAIVHHNQPQ-WLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL----YFH 537
Query: 938 SWFNMLD--LLVVSVSLISFGIHSSAISV-VKILRVLRVLRPLRAINRAKGLKHVVQCVF 994
S FN D + V S+ + + I S + +LR LR+LR + L+++V +
Sbjct: 538 SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLM 597
Query: 995 VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSR 1054
++++I +++ + L +FA +G+QLF G+F + DG S
Sbjct: 598 SSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN-------------------FNDGTPSA 638
Query: 1055 PLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEIS 1114
NFD +A+M +F + T E W ++Y I + +++ +
Sbjct: 639 -------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWS-----A 680
Query: 1115 VFFIVYIIIIAFFMMNIFVGFVIITFRAQGE--QEYQNCELDKNQRQCVEYALKAQPL 1170
++FIV + + ++N+F+ + E ++ Q E NQ+ ++ A + P+
Sbjct: 681 IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM 738
Score = 136 bits (342), Expect = 2e-31
Identities = 109/377 (28%), Positives = 181/377 (48%), Gaps = 44/377 (11%)
Query: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
K++ + K +T A ++F + NP+RR+C IV + F++ ILL I A+ +A
Sbjct: 1113 KKKQKKEKRET---GKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIA 1169
Query: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
L P + N L +YVF +FT E V+K++ GL+L +Y R+ WN+LDF
Sbjct: 1170 LAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDF 1227
Query: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
++VV L + L G T +K+LR RVLRPL+ + +P L V +
Sbjct: 1228 VVVVGALVAFALANALG-------TNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFD 1280
Query: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
++ +L + +I ++ + I+A+I ++LF G K Y S + E++ G+
Sbjct: 1281 CVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKG---KFFYCTDSSKDTEKE-----CIGN 1332
Query: 289 GRACTLNQTECRGR-WPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQD------ 341
N+ E +GR W ++DN +A+LT+F T EGW VL D
Sbjct: 1333 YVDHEKNKMEVKGREWKRHE---FHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDR 1389
Query: 342 ----AMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQM 397
+ E+ Y V V+F FFV N+ + ++ F ++ GD K E+ +
Sbjct: 1390 GPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMMEECSL 1439
Query: 398 EEDLRGYLDWITQAEEL 414
E++ R +D+ A+ L
Sbjct: 1440 EKNERACIDFAISAKPL 1456
Score = 117 bits (294), Expect = 9e-26
Identities = 83/315 (26%), Positives = 146/315 (46%), Gaps = 43/315 (13%)
Query: 1154 DKNQRQCVEYALKAQPLRRYIPKNP---------HQYRVWAT-----VNSAAFEYLMFLL 1199
D + CV+ + PL R K+ H+ R+ V S F +++ L
Sbjct: 426 DSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSL 485
Query: 1200 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDA 1259
+ LNT +A+ H+ Q + + +F GLF +EM LK+ P+ YF ++N FD
Sbjct: 486 VALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDF 545
Query: 1260 LIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1319
+ VGSI ++ G G I+ R R++R+ K+ +R L+ +
Sbjct: 546 GVTVGSIFEVVWAIFRPGTSFG----------ISVLRALRLLRIFKITKYWASLRNLVVS 595
Query: 1320 FIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNNFQTFPQAVLLLFR 1378
+ S +++ + L+ + ++A++GMQ+F G+ DGT + NF TFP A++ +F+
Sbjct: 596 LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQ 652
Query: 1379 CATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVA 1438
TGE W E+M + S G ++ YFI + + ++N+F+A
Sbjct: 653 ILTGEDWNEVMYNGI-------RSQGG-----VSSGMWSAIYFIVLTLFGNYTLLNVFLA 700
Query: 1439 VIMDNF---DYLTRD 1450
+ +DN LT+D
Sbjct: 701 IAVDNLANAQELTKD 715
Score = 106 bits (264), Expect = 3e-22
Identities = 93/342 (27%), Positives = 158/342 (46%), Gaps = 30/342 (8%)
Query: 850 AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYF 907
+ F + N +RK LI F +IL II + + LA E P + + L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 908 DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVV-SVSLISFGIHSSAISVVK 966
+ F IF E +K+ G H+GS+ R+ +N++D +VV S L + G H + ++
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 967 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRE-RLWVNSD---FNFDNVLSAMMALFTV 1082
+ + +G +P G P E + W+ + FDN+L A++ +F
Sbjct: 248 HRAC--FMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQC 305
Query: 1083 STFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRA 1142
T EGW +LY DA G +N+ ++FI III +FF++N+ +G + F
Sbjct: 306 ITMEGWTTVLYNTNDAL----GATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAK 356
Query: 1143 QGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVW 1184
+ E+ K +RQ + I + + YR W
Sbjct: 357 ERERVENRRAFMKLRRQ------------QQIERELNGYRAW 386
Score = 99.8 bits (247), Expect = 2e-20
Identities = 74/299 (24%), Positives = 142/299 (47%), Gaps = 18/299 (6%)
Query: 480 ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANR-VLRARCRRAVKSNACYWAVLL 537
+ QGD+ EE +L R C++ + + R NR + R V S + + ++
Sbjct: 1427 QEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMA 1486
Query: 538 LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597
++ LNT+ + +++ P +Y N +F++E +LK+ G Y +N FD
Sbjct: 1487 MIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD 1546
Query: 598 CFVVCGGILETTLVEVGAMQPLG--ISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655
V G I E L + + G +S L+ R R+ K+ R ++ L+ + + S K+
Sbjct: 1547 FITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1606
Query: 656 IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWN 714
+ + LL+ + I++++GMQ+FG +++H R + F +F +L+ +F+ TGE W
Sbjct: 1607 LPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQ 1666
Query: 715 VVMYDGIMAYG------GPFFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 760
+M + G P L +YF+ ++++LN+F+A+ +DN
Sbjct: 1667 EIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
Score = 96.3 bits (238), Expect = 3e-19
Identities = 102/417 (24%), Positives = 174/417 (41%), Gaps = 92/417 (22%)
Query: 43 SGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTI 102
S +GTP R K V+ + R L R S +V+ + F ++L +
Sbjct: 436 SSVGTPLARASIKSAKVDGVSYFRHKERLL---------RISIRHMVKSQVFYWIVLSLV 486
Query: 103 FAN--CVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIR 160
N CVA+ + H L E++FL +F +E LK+ G P Y
Sbjct: 487 ALNTACVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG----PRLYFH 537
Query: 161 NGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGV 220
+ +N DF + V +F V+ RPG + F + LRA R+LR ++
Sbjct: 538 SSFNCFDFGVTVGSIFEVVW--AIFRPGTS---------FGISVLRALRLLRIFKITKYW 586
Query: 221 PSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDP 280
SL ++ S+M ++ ++ + L+ I+++A++G++LF GR + D
Sbjct: 587 ASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN------------FNDG 634
Query: 281 SPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340
+P A NFD F A++TVFQ +T E W +V+Y
Sbjct: 635 TPSA---------------------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
Query: 341 DAMG--YELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQ 396
+ G W +YF+ L +FG++ +LN+ L + + +E K +Q
Sbjct: 668 RSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK----------DEQ 717
Query: 397 MEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGH-----RPQLAELTNRRR 448
EE+ + +A+E+ P + N+ S+ + R H P+ + L RRR
Sbjct: 718 EEEEAFNQKHALQKAKEV---SPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRR 771
Score = 85.1 bits (209), Expect = 6e-16
Identities = 64/270 (23%), Positives = 123/270 (45%), Gaps = 74/270 (27%)
Query: 127 LEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR 186
L+ + F ++F++E VLK++A+G + Y R+ WN+ DFI V+ + ++L
Sbjct: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL------ 1559
Query: 187 PGDAPHTGGK---PGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALL 243
T K GF++ L+ FR R ++L+ ++ I+L + +++ L ++ LL
Sbjct: 1560 ------TDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1613
Query: 244 VLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRW 303
+ + IYAIIG+++F +++ +E+ +N+
Sbjct: 1614 IAMLFFIYAIIGMQVF------------GNIKLDEESH------------INRH------ 1643
Query: 304 PGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWM------------------QDAMGY 345
NF +FF +++ +F+ T E W +++ + G
Sbjct: 1644 -------NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGT 1696
Query: 346 ELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375
+L +VYFVS + F SF +LNL + V+ F
Sbjct: 1697 DLAYVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
Score = 76.6 bits (187), Expect = 2e-13
Identities = 66/286 (23%), Positives = 128/286 (44%), Gaps = 49/286 (17%)
Query: 518 LRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLT----QIQEYANKVLLCLFT 573
+R C V +LL++ +++ +A+E PV ++ Y + V +FT
Sbjct: 1142 IRRACHYIVNLRYFEMCILLVIAASSIALAAE---DPVLTNSERNKVLRYFDYVFTGVFT 1198
Query: 574 VEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVE-VGAMQPLGISVLRCVR 628
EM++K+ G +Y +N D VV G ++ L +G + I ++ +R
Sbjct: 1199 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
Query: 629 LLRIFKVTRHWASLSNLVA---SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 685
+LR+ + + L L A ++ S+K++ ++L++ LF+ IF+++ +QLF GKF F
Sbjct: 1259 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF-FY 1317
Query: 686 QTHTKRST-----------------------------FDTFPQALLTVFQILTGEDWNVV 716
T + + T +D ALLT+F + TGE W V
Sbjct: 1318 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQV 1377
Query: 717 MYDGIMAYGGPFFPG----MLVCIYFIILFICGNYILLNVFLAIAV 758
+ + P M + I++++ F+ + +N+F+A+ +
Sbjct: 1378 LQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALII 1423
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 327 bits (838), Expect = 7e-89
Identities = 268/935 (28%), Positives = 452/935 (48%), Gaps = 70/935 (7%)
Query: 761 LASGDAGTAKDKGGEKSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEE 820
+A G++ E S+E D+ + E L E GA E E+ E E EE
Sbjct: 1107 IAVGESDFENLNTEEFSSESDMEESKEKL--NATSSSEGSTVDIGAPAEGEQPEVEPEES 1164
Query: 821 EEEEEGAGGVELLQEVVPKEKV--VPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLIL 878
E E ++ V K K + I EG + LRK C+ ++ H+ F I+
Sbjct: 1165 LEPEAC-----FTEDCVRKFKCCQISIEEGKGKLWWN----LRKTCYKIVEHNWFETFIV 1215
Query: 879 VFIILSSVSLAAEDP-IRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCR 937
I+LSS +LA ED I +L Y D FT IF +E+LLK +G ++ F
Sbjct: 1216 FMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY---FTN 1272
Query: 938 SWFNMLDLLVVSVSLISFGIHS---SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 994
+W LD L+V VSL+S ++ S + +K LR LR LRPLRA++R +G++ VV +
Sbjct: 1273 AWC-WLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALL 1331
Query: 995 VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLV--YPDGDV 1052
AI +I N+++V + +F+ +GV LF GKFY C + +T E +V Y +
Sbjct: 1332 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN---YTTGEMFDVSVVNNYSECKA 1388
Query: 1053 SRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVE 1112
+ W N NFDNV ++L V+TF+GW ++Y A+D+ + P Y +
Sbjct: 1389 LIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLY 1448
Query: 1113 ISVFFIVYIIIIAFFMMNIFVGFVIITFRAQ----GEQEYQNCELDKNQRQCVEYALKAQ 1168
+ ++F+++II +FF +N+F+G +I F Q G Q+ E K ++ +
Sbjct: 1449 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
Query: 1169 PLRRY-IPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNM 1227
P + P N Q V+ V F+ + +LI LN V + ++ +Q+ + +N+
Sbjct: 1509 PQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINL 1568
Query: 1228 VFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDS 1287
VF LFT E VLK+I+ + +YFT WN FD ++V+ SIV + + E+ +
Sbjct: 1569 VFIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL----------IEK 1617
Query: 1288 SRISITFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVI 1344
+S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FIYA+
Sbjct: 1618 YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIF 1677
Query: 1345 GMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGN--RCDPES 1402
GM F V + G I+ NF+TF +++ LF+ T W ++ L CDP+
Sbjct: 1678 GMSNFAYVKREVG--IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735
Query: 1403 DF-GPGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHL 1459
D G + CG+ + I +F+S+ ++ +++N+++AVI++NF T + + L
Sbjct: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795
Query: 1460 DEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDG 1519
+ F +W ++DP A I+ + + PPL K P++V +L+AM++P+ S
Sbjct: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGD 1850
Query: 1520 TVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDE-EEV 1578
+ LFA + L E + + E R + K + + + +E +
Sbjct: 1851 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAI 1910
Query: 1579 TVGKFYATFLIQDYFRKFRR--RKEKGLLGNDAAPSTSSAL-----QAGLRSLQDLGPEM 1631
+ + Y +L++ +K +K+KG D P L + D+ P
Sbjct: 1911 IIQRAYRRYLLKQKVKKVSSIYKKDKG-KECDGTPIKEDTLIDKLNENSTPEKTDMTPST 1969
Query: 1632 RQALTCDT----EEEEEEGQEGVEEEDEKDLETNK 1662
+ D+ E+E+ E + +E+ KD+ +K
Sbjct: 1970 TSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESK 2004
Score = 149 bits (377), Expect = 2e-35
Identities = 116/442 (26%), Positives = 199/442 (45%), Gaps = 80/442 (18%)
Query: 57 HKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFP 116
+K A++ +P AL+ LT NP+R+ I I+ F++LI+ TI NCV + + P P
Sbjct: 95 NKGKAISRFSATP-ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-P 152
Query: 117 EDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLF 176
+ N VEY F I+T E+++KI+A G L ++R+ WN LDF ++
Sbjct: 153 DWTKN--------VEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204
Query: 177 SVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVP 236
+ + G +V ALR FRVLR L+ +S +P L ++ ++++++
Sbjct: 205 TEFVNLG-----------------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 247
Query: 237 LLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSD----------------------- 273
L + +L +F + ++A+IGL+LF+G + C D
Sbjct: 248 LSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTF 307
Query: 274 ---------------------MEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITN 312
+E + D C +S C C PN G T+
Sbjct: 308 NRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYI-CVKAGRNPNYGYTS 366
Query: 313 FDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLS 372
FD F +A L++F+ +T + W + LY + + ++FV ++ GSF+++NL+L V++
Sbjct: 367 FDTFSWAFLSLFRLMTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
Query: 373 GEFSKEREKAKARGDFQKQREKQQMEEDLRGYLD---WITQAEELDMEDPSADDNLGSMA 429
+ +E+ +A QK+ E QQM E L+ + A + D S +G +
Sbjct: 426 MAY-EEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFS 484
Query: 430 EEGRAGHR---PQLAELTNRRR 448
E + EL NRR+
Sbjct: 485 ESSSVASKLSSKSEKELKNRRK 506
Score = 142 bits (357), Expect = 4e-33
Identities = 144/682 (21%), Positives = 282/682 (41%), Gaps = 146/682 (21%)
Query: 518 LRARCRRAVKSNACYWAVLLLVFLNTLTIASE--HHGQPVWLTQIQEYANKVLLCLFTVE 575
LR C + V+ N ++ ++ L++ +A E + Q + + EYA+KV +F +E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 576 MLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKV 635
MLLK G Y ++ + D +V ++ T +G + I LR +R LR +
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
Query: 636 TRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK----- 690
+ + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF +T
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376
Query: 691 -------------------------RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYG 725
+ FD L++ Q+ T + W +MY + +
Sbjct: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436
Query: 726 GPFFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKD 781
P + + +YF+I I G++ LN+F+ + +DN K K G
Sbjct: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF-----NQQKKKFG------- 1484
Query: 782 LPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEK 841
G D+ EE+++ ++++ K+
Sbjct: 1485 -----------------------GQDIFMTEEQKKY------------YNAMKKLGSKKP 1509
Query: 842 VVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRN 901
PIP N + + VF I++ I L+ V++ E ++ N
Sbjct: 1510 QKPIPR--------PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTN 1561
Query: 902 HILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGI---- 957
IL + + F +FT E +LK+ + F W N+ D +VV +S++ +
Sbjct: 1562 -ILYWINLVFIVLFTGECVLKLISLRYYY----FTIGW-NIFDFVVVILSIVGMFLAELI 1615
Query: 958 --HSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1015
+ + ++ +++R+ R+ R LR I AKG++ ++ + +++ + NI ++ L+ F++A
Sbjct: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675
Query: 1016 CIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSA 1075
G+ F V+ + ++ FNF+ ++
Sbjct: 1676 IFGMSNF--------------------------------AYVKREVGIDDMFNFETFGNS 1703
Query: 1076 MMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNY----------RVEISVFFIVYIIIIA 1125
M+ LF ++T GW LL +++ D P ++ + +FF V III+
Sbjct: 1704 MICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIIS 1763
Query: 1126 FF-MMNIFVGFVIITFRAQGEQ 1146
F ++N+++ ++ F E+
Sbjct: 1764 FLVVVNMYIAVILENFSVATEE 1785
Score = 141 bits (355), Expect = 7e-33
Identities = 103/330 (31%), Positives = 161/330 (48%), Gaps = 45/330 (13%)
Query: 81 LRRSCISIVEWKPFDILILLTIFANCVALG---VYIPFPEDDSNTANHNLEQVEYVFLVI 137
LR++C IVE F+ I+ I + AL +YI + T LE + VF I
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
Query: 138 FTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKP 197
F +E +LK VAYG Y N W LDF+IV V L S+ A G
Sbjct: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLT----------ANALGYSE 1298
Query: 198 GGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLE 257
G +K+LR R LRPLR +S + +V+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 1299 LGA-IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
Query: 258 LFLGRM-HKTCYFLGS--DMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFD 314
LF G+ H Y G D+ + S C + L ++ RW NFD
Sbjct: 1358 LFAGKFYHCINYTTGEMFDVSVVNNYSECKA--------LIESNQTARWKNVK---VNFD 1406
Query: 315 NFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP---------WVYFVSLVIFGSFFVLN 365
N L++ Q T +GW D++Y D+ EL ++YFV +IFGSFF LN
Sbjct: 1407 NVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLN 1466
Query: 366 LVLGVLSGEFSKEREKAKARGDFQKQREKQ 395
L +GV+ F+++++K + F + +K+
Sbjct: 1467 LFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
Score = 125 bits (315), Expect = 3e-28
Identities = 80/252 (31%), Positives = 134/252 (53%), Gaps = 20/252 (7%)
Query: 534 AVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFF 593
A+ + + LNTL +A EH+ + + N V +FT EM LK+ + P Y +
Sbjct: 764 AITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGW 823
Query: 594 NRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSM 653
N FD F+V +L+E+G G+SVLR RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 824 NIFDGFIV-----SLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 878
Query: 654 KSIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDQTHTKRSTFDTFPQALLTVFQI 707
++ +L L+L + + IF+++GMQLFG + + R F + L VF++
Sbjct: 879 GALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRV 938
Query: 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLASGDA 766
L GE W M+D + G +C+ F+++ + GN ++LN+FLA+ + + +S D
Sbjct: 939 LCGE-WIETMWDCMEV------AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSS-DN 990
Query: 767 GTAKDKGGEKSN 778
A D E +N
Sbjct: 991 LAATDDDNEMNN 1002
Score = 120 bits (301), Expect = 1e-26
Identities = 75/252 (29%), Positives = 127/252 (50%), Gaps = 37/252 (14%)
Query: 1198 LLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTF 1257
+ I+LNT+ +AM+HY T F+ + + N+VFTG+FT EM LKIIA P +YF + WN F
Sbjct: 767 ICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIF 826
Query: 1258 DALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLL 1317
D IV S++++ + V ++ R FR++R+ KL + L+
Sbjct: 827 DGFIVSLSLMELGLANVE---------------GLSVLRSFRLLRVFKLAKSWPTLNMLI 871
Query: 1318 WTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNN-----NFQTFPQA 1372
S AL + L++A+I FI+AV+GMQ+FGK + +I+ + + F +
Sbjct: 872 KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHS 931
Query: 1373 VLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLI 1432
L++FR GE W E M + G + F+ ++ ++
Sbjct: 932 FLIVFRVLCGE-WIETMWDCME----------------VAGQTMCLTVFMMVMVIGNLVV 974
Query: 1433 INLFVAVIMDNF 1444
+NLF+A+++ +F
Sbjct: 975 LNLFLALLLSSF 986
Score = 88.6 bits (218), Expect = 6e-17
Identities = 66/263 (25%), Positives = 123/263 (46%), Gaps = 35/263 (13%)
Query: 787 EGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIP 846
E L ++ EE A+R + ++E++E + + E G + ++ P+ VP+
Sbjct: 20 ESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLE 79
Query: 847 E-------------------------GSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFI 881
+ A + L+ NP+RK ++ H +F LI+ I
Sbjct: 80 DLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTI 139
Query: 882 ILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFN 941
+ + V + +P + ++ +Y FT I+T E L+K+ G L +F R +N
Sbjct: 140 LTNCVFMTMSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
Query: 942 MLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG 1001
LD V++ + ++ ++ +S LR RVLR L+ I+ GLK +V + +++ +
Sbjct: 193 WLDFTVITFAYVTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249
Query: 1002 NIMIVTTLLQFMFACIGVQLFKG 1024
++MI+T +FA IG+QLF G
Sbjct: 250 DVMILTVFCLSVFALIGLQLFMG 272
Score = 88.2 bits (217), Expect = 7e-17
Identities = 73/295 (24%), Positives = 132/295 (44%), Gaps = 59/295 (20%)
Query: 86 ISIVEWKPF-DILILLTIFANCVALGV-YIPFPEDDSNTANHNLEQVEYVFLVIFTVETV 143
+++V PF D+ I + I N + + + + P E S+ L VF IFT E
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
Query: 144 LKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVK 203
LKI+A + P Y + GWN+ D IV + L + L G +
Sbjct: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------------LS 847
Query: 204 ALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRM 263
LR+FR+LR +L P+L++++ I ++ L ++ L++ ++ I+A++G++LF G+
Sbjct: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
Query: 264 HKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTV 323
+K C C ++ RW + +FF + L V
Sbjct: 907 YKEC-----------------------VCKISNDCELPRW--------HMHDFFHSFLIV 935
Query: 324 FQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 378
F+ + E W + ++ + G + F+ +++ G+ VLNL L +L FS +
Sbjct: 936 FRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Score = 81.6 bits (200), Expect = 7e-15
Identities = 84/366 (22%), Positives = 154/366 (42%), Gaps = 79/366 (21%)
Query: 78 ANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVI 137
AN + V + FDI I++ I N V + V +D S + L + VF+V+
Sbjct: 1517 ANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVET---DDQSQEMTNILYWINLVFIVL 1573
Query: 138 FTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKP 197
FT E VLK+++ Y GWN+ DF++V++ + + L + + +P
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTL---- 1624
Query: 198 GGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLE 257
+ +R R+ R LRL+ G + +L ++M +L L +I LL+ V+ IYAI G+
Sbjct: 1625 ----FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
Query: 258 LFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFF 317
F ++ ++ ++ + NF+ F
Sbjct: 1681 NFA--------YVKREVGIDD-------------------------------MFNFETFG 1701
Query: 318 FAMLTVFQCVTMEGWTDVLYWM-----------QDAMGYEL------PWV---YFVSLVI 357
+M+ +FQ T GW +L + +D G + P V +FVS +I
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
Query: 358 FGSFFVLNLVLGVLSGEFS---KEREKAKARGDFQKQREK-QQMEEDLRGYLDWITQAEE 413
V+N+ + V+ FS +E + + DF+ E ++ + D ++++ ++
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
Query: 414 LDMEDP 419
D DP
Sbjct: 1822 ADALDP 1827
Score = 79.0 bits (193), Expect = 4e-14
Identities = 72/278 (25%), Positives = 129/278 (46%), Gaps = 49/278 (17%)
Query: 534 AVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFF 593
++++L+ LN +T+ E Q +T I + N V + LFT E +LKL L Y + +
Sbjct: 1536 SIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFTIGW 1594
Query: 594 NRFDCFVVC---GGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLL 650
N FD VV G+ L+E + P V+R R+ RI ++ + + L+ +L+
Sbjct: 1595 NIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALM 1654
Query: 651 NSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRS-------TFDTFPQALLT 703
S+ ++ ++ LLLFL + I+++ GM F + KR F+TF +++
Sbjct: 1655 MSLPALFNIGLLLFLVMFIYAIFGMSNF--------AYVKREVGIDDMFNFETFGNSMIC 1706
Query: 704 VFQILTGEDWNVVMYDGIMA---YGGP-------FFPGMLV----------CIYFIILFI 743
+FQI T W DG++A GP PG V +F+ I
Sbjct: 1707 LFQITTSAGW-----DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
Query: 744 CGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKD 781
+++N+++A+ ++N + A ++ E +E D
Sbjct: 1762 ISFLVVVNMYIAVILENFS-----VATEESAEPLSEDD 1794
Score = 66.2 bits (160), Expect = 3e-10
Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 7/153 (4%)
Query: 877 ILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFC 936
I + I+L+++ +A E F + +L + FT IFT E+ LK+ + + F
Sbjct: 765 ITICIVLNTLFMAMEHYPMTEQFSS-VLSVGNLVFTGIFTAEMFLKIIAMDPYYY---FQ 820
Query: 937 RSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA 996
W N+ D +VS+SL+ G+ + + + +LR R+LR + L +++ + +
Sbjct: 821 EGW-NIFDGFIVSLSLMELGL--ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 877
Query: 997 IRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTC 1029
+ +GN+ +V ++ F+FA +G+QLF + C
Sbjct: 878 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
Score = 61.2 bits (147), Expect = 9e-09
Identities = 47/179 (26%), Positives = 85/179 (47%), Gaps = 26/179 (14%)
Query: 1175 PKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFT 1234
P NP + + + F L+ IL N V + M + P ++ ++ FTG++T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSN-----PPDWTKNV-EYTFTGIYT 167
Query: 1235 IEMVLKIIA----FKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRI 1290
E ++KI+A + + D WN D ++ + V TE N G+
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV----TEFVNLGN----------- 212
Query: 1291 SITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF 1349
++ R FRV+R +K +S G++T++ I+S + L V +L ++A+IG+Q+F
Sbjct: 213 -VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 46.2 bits (108), Expect = 3e-04
Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 10/114 (8%)
Query: 571 LFTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRC 626
++T E L+K+ G ++ +N D F V T V +G +S LR
Sbjct: 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLD-FTVITFAYVTEFVNLG-----NVSALRT 218
Query: 627 VRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 680
R+LR K L +V +L+ S+K ++ +++L + +F+L+G+QLF G
Sbjct: 219 FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/144 (22%), Positives = 67/144 (46%), Gaps = 23/144 (15%)
Query: 692 STFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLN 751
++FDTF A L++F+++T + W + + A G + I+F+++ G++ L+N
Sbjct: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLIN 418
Query: 752 VFLAIAVDNLASGDAGTAKDKGGEKSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEE 811
+ LA+ + T E++ +K+ E + ++ ++K++EE A
Sbjct: 419 LILAVVAMAYEEQNQATL-----EEAEQKE--AEFQQMLEQLKKQQEEAQAAAAA----- 466
Query: 812 EEEEEEEEEEEEEEGAGGVELLQE 835
E + GAGG+ + E
Sbjct: 467 -----ASAESRDFSGAGGIGVFSE 485
Score = 34.3 bits (77), Expect = 1.2
Identities = 21/101 (20%), Positives = 46/101 (45%), Gaps = 10/101 (9%)
Query: 1068 NFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFF 1127
+FD A ++LF + T + W L + A + + +FF++ I + +F+
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
Query: 1128 MMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQ 1168
++N+ + V + + Q + + E + + Q + LK Q
Sbjct: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,915,089
Number of Sequences: 37866
Number of extensions: 4086709
Number of successful extensions: 61732
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 610
Number of HSP's successfully gapped in prelim test: 246
Number of HSP's that attempted gapping in prelim test: 30251
Number of HSP's gapped (non-prelim): 16389
length of query: 1977
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1860
effective length of database: 13,817,196
effective search space: 25699984560
effective search space used: 25699984560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.