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Search of human proteins with 52421790
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52421790 mitogen-activated protein kinase kinase kinase 9
[Homo sapiens]
(1118 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 2270 0.0
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 979 0.0
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 920 0.0
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 700 0.0
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 246 7e-65
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 244 3e-64
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 228 3e-59
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 228 3e-59
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 166 1e-40
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 166 1e-40
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 166 1e-40
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 166 1e-40
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 149 1e-35
gi|4503787 fyn-related kinase [Homo sapiens] 146 1e-34
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 144 4e-34
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 144 4e-34
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 142 2e-33
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 142 2e-33
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 142 2e-33
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 142 2e-33
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 137 7e-32
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 137 7e-32
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 135 2e-31
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 135 2e-31
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 135 2e-31
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 135 2e-31
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 135 2e-31
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 135 2e-31
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 135 2e-31
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 135 2e-31
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 2270 bits (5882), Expect = 0.0
Identities = 1118/1118 (100%), Positives = 1118/1118 (100%)
Query: 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV 60
MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
Sbjct: 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV 60
Query: 61 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR 120
FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
Sbjct: 61 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR 120
Query: 121 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED 180
CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
Sbjct: 121 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED 180
Query: 181 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD 240
ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
Sbjct: 181 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD 240
Query: 241 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE 300
ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
Sbjct: 241 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE 300
Query: 301 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG 360
WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
Sbjct: 301 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG 360
Query: 361 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH 420
VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
Sbjct: 361 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH 420
Query: 421 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL 480
CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
Sbjct: 421 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL 480
Query: 481 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK 540
ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
Sbjct: 481 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK 540
Query: 541 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG 600
SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
Sbjct: 541 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG 600
Query: 601 PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP 660
PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP
Sbjct: 601 PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP 660
Query: 661 RSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRG 720
RSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRG
Sbjct: 661 RSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRG 720
Query: 721 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG 780
EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG
Sbjct: 721 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG 780
Query: 781 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG 840
FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG
Sbjct: 781 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG 840
Query: 841 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE 900
DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE
Sbjct: 841 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE 900
Query: 901 RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML 960
RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML
Sbjct: 901 RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML 960
Query: 961 KTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDP 1020
KTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDP
Sbjct: 961 KTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDP 1020
Query: 1021 WWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERT 1080
WWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERT
Sbjct: 1021 WWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERT 1080
Query: 1081 LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 1118
LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
Sbjct: 1081 LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 1118
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 979 bits (2532), Expect = 0.0
Identities = 582/1086 (53%), Positives = 697/1086 (64%), Gaps = 157/1086 (14%)
Query: 35 EEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGW 94
EEEE A A E G P WTAVF+YEAAG++ELTLR GD V+VLS+D VSGDEGW
Sbjct: 2 EEEEGAVAK---EWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGW 58
Query: 95 WTGQL-NQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQL-LEIDFAELTLEEIIGI 152
WTGQL + RVG+FPSNYV P + P+ +QL EI F EL LEEIIG+
Sbjct: 59 WTGQLPSGRVGVFPSNYVAPGA------------PAAPAGLQLPQEIPFHELQLEEIIGV 106
Query: 153 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 212
GGFGKVYRA W G+EVAVKAAR DP++D + T E V QEA+LF L+HPNIIALRG CL
Sbjct: 107 GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLN 166
Query: 213 EPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSS 272
P+LCLVME+ARGG L+RVL+G+R+PP +LVNWAVQ+ARGMNYLH++A VPIIHRDLKS
Sbjct: 167 PPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226
Query: 273 NILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDV 332
NILIL+ +EN +L++ +LKITDFGLAREWH+TTKMSAAGTYAWMAPEVIR S+FSK SDV
Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDV 286
Query: 333 WSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHS 392
WS+GVLLWELLTGEVP+R ID LAVAYGVAMNKL LPIPSTCPEPFA+L+E+CW+PDPH
Sbjct: 287 WSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHG 346
Query: 393 RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELT 452
RP F +IL +L IE+S F+MP +SFH LQ++WK EIQ MFD LR KEKELR+ EEEL
Sbjct: 347 RPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELL 406
Query: 453 RAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSR-LK 511
RAA +Q+ QEE LRRREQELAERE+DI+EREL++++ QL QEKPRV+KRKG F++SR LK
Sbjct: 407 RAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLK 466
Query: 512 LKD-GNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGE-- 568
L++ G+ ISLPS F+HK TVQASPT+DKRK + +SPPASP+IIPRLRAI+LTP +
Sbjct: 467 LREGGSHISLPSGFEHKITVQASPTLDKRKG--SDGASPPASPSIIPRLRAIRLTPVDCG 524
Query: 569 ---------SSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQR 619
S TW R PK +EE KKKGRTWGP + QKE G+E
Sbjct: 525 GSSSGSSSGGSGTWSRGG-PPK----KEELVGGKKKGRTWGPSSTLQKERVGGEE----- 574
Query: 620 REKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMALLA 679
LK L +G KQWSSSAPNL K P+ +P PGF SL EM
Sbjct: 575 ------------------RLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEM---- 612
Query: 680 ASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVN 739
EE ++E GS +S + SYL +P P EP+P
Sbjct: 613 ---------EEFAEAEDGGSSVPPSPYS-TPSYLSVPLP--------------AEPSPGA 648
Query: 740 SATSTPQLTPTNSLKR-GGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPE 798
A P TP+ R G RRC++ALLGC +L A GLG D+ EA
Sbjct: 649 RAPWEP--TPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAAD-------- 698
Query: 799 PPAREEKKRREGL-FQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISEC 857
E+++ +GL F R+ R R SPP+R ++E+ LG + S TL+SLSS+S+C
Sbjct: 699 --GEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLG-LAPSATLVSLSSVSDC 755
Query: 858 NSTRSLLRSDSDE---IVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH 914
NSTRSLLRSDSDE P P P SP T NPLV++ +E FK+DP QSLTPTH
Sbjct: 756 NSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPST-NPLVDLELESFKKDPRQSLTPTH 814
Query: 915 VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR 974
VT + HRRTPSDGAL P G P P RD +FPR
Sbjct: 815 VTAAC-AVSRGHRRTPSDGALGQR-----GPPEPAGHGPGP-----------RDLLDFPR 857
Query: 975 LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP 1034
LPDP +FP R RP TL F PRPRP+A+R RLDPW VS + SP
Sbjct: 858 LPDPQALFPARRR-----PPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISP 912
Query: 1035 ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST 1094
S +TP E PG P++ P TLLD+D EGQ+QDST
Sbjct: 913 --PSRPDTP---------------ESPGPPSVQP-----------TLLDMDMEGQNQDST 944
Query: 1095 VPLCRA 1100
VPLC A
Sbjct: 945 VPLCGA 950
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 920 bits (2379), Expect = 0.0
Identities = 548/1145 (47%), Positives = 698/1145 (60%), Gaps = 177/1145 (15%)
Query: 24 GAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLS 83
GA G+ +A+ G G W A+++YEA GEDEL+LR G +VEVLS
Sbjct: 19 GAPGGSASSSSTSSGGSASAGAG---------LWAALYDYEARGEDELSLRRGQLVEVLS 69
Query: 84 KDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGED-PSCYPPIQLLEIDFA 142
+D+ VSGDEGWW GQ+ +R+GIFP+NYV P C+P P P + + F
Sbjct: 70 QDAAVSGDEGWWAGQVQRRLGIFPANYVAP-------CRPAASPAPPPSRPSSPVHVAFE 122
Query: 143 ELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 202
L L+E+IG GGFG+VYRA W G EVAVKAAR DP++D + E+VR+EA+LFAML+HPN
Sbjct: 123 RLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 182
Query: 203 IIALRGVCLKEPNLCLVMEFARGGPLNRVLSG---------------KRIPPDILVNWAV 247
II LRGVCL++P+LCLV+EFARGG LNR L+ +RIPP +LVNWAV
Sbjct: 183 IIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAV 242
Query: 248 QIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM 307
QIARGM YLH+EA VPI+HRDLKSSNIL+L+K+E+ D+ NK LKITDFGLAREWHRTTKM
Sbjct: 243 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM 302
Query: 308 SAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA 367
S AGTYAWMAPEVI++S+FSKGSD+WSYGVLLWELLTGEVP+RGIDGLAVAYGVA+NKL
Sbjct: 303 STAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 362
Query: 368 LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWK 427
LPIPSTCPEPFAKLM++CW DPH RPSF IL+QLT IE + EMP++SFH +QD+WK
Sbjct: 363 LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWK 422
Query: 428 HEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNII 487
EIQ+MFD+LR KEKELR+ EEELTRAALQQK+QEELL+RREQ+LAEREID+LERELNI+
Sbjct: 423 LEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNIL 482
Query: 488 IHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRS 547
I QL QEKP+VKKRKGKF++SRLKLKDG+RISLPSDFQHK TVQASP +DKR+SL +S S
Sbjct: 483 IFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSS 542
Query: 548 SPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQK 607
SPP+SPT++PRLRAIQLT ES+KTWGR++V +EE E+ KR KKKG TWGP ++ K
Sbjct: 543 SPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEE-FEDVKRNFKKKGCTWGPNSIQMK 601
Query: 608 ELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALP 667
+ E ++ L DG WS+ L+K ++ P
Sbjct: 602 DRTDCKE-----------------------RIRPLSDGNSPWSTI---LIKNQKTMP--- 632
Query: 668 GFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHS-------PSQSYLCIPFPRG 720
+ + +++ E P L+H PSQ+Y+ +P +
Sbjct: 633 ---------------LASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKD 677
Query: 721 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG 780
+ P+ EE N+AT + ++TPTNSL R ++ E AL GC +LA+ LG
Sbjct: 678 AQRENPAEAESWEEAASANAATVSIEMTPTNSLSR-SPQRKKTESALYGCTVLLASVALG 736
Query: 781 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEE----PM 836
DL E K Q EEP P +EEKK+REG+FQR+S+ RRS SPP+ E P
Sbjct: 737 LDLRELHKAQ--AAEEPLP--KEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPS 792
Query: 837 LLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPV---SPVEAPPLSPCTHN- 892
L L S++L +LS S ST+ LL+ DS++ +V PV S + P P
Sbjct: 793 LPL---SSALGILSTPSF----STKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGS 845
Query: 893 -------PLVNVRVERFKRDPNQSLTPT----HVTLTTPSQPSSHRRTPSDGALKP--ET 939
P ++ + P+ L T ++ +PS HRRT SDG P T
Sbjct: 846 GREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGAT 905
Query: 940 LLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLER 999
++++ S+ L PSP P P V P ++
Sbjct: 906 IISATGASALPLCPSPA----------------PHSHLPREVSP--------------KK 935
Query: 1000 PKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEE 1059
T+ +P+ RP++ R R D P T+ + + T + V
Sbjct: 936 HSTVHIVPQRRPASLRSRSD-----LPQAYPQTAVSQLAQT--------------ACVVG 976
Query: 1060 RPGLPALLPFQAGPLPPTERT------LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQ 1113
RPG P L ERT LLD D EGQS+D TVPLCR T RP+ YE++
Sbjct: 977 RPG-----PHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELE 1031
Query: 1114 QEFWS 1118
+EF S
Sbjct: 1032 KEFLS 1036
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 700 bits (1806), Expect = 0.0
Identities = 380/704 (53%), Positives = 475/704 (67%), Gaps = 44/704 (6%)
Query: 21 GEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVE 80
G G G G E +AA P WTA+F+YE +G+DEL LR GD VE
Sbjct: 20 GSGGGGGGGGGRPEGSPKAAGYANP----------VWTALFDYEPSGQDELALRKGDRVE 69
Query: 81 VLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEID 140
VLS+D+ +SGDEGWW GQ+ +VGIFPSNYV+ GG P C
Sbjct: 70 VLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSR----------GGGPPPCEVA------S 113
Query: 141 FAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 200
F EL LEE+IGIGGFGKVYR W G+ VAVKAAR DPDEDIS T E+VRQEA+LFAML H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 201 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEA 260
PNIIAL+ VCL+EPNLCLVME+A GGPL+R L+G+R+PP +LVNWAVQIARGM+YLH EA
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEA 233
Query: 261 IVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEV 320
+VP+IHRDLKS+NIL+LQ +E+ D+ +K LKITDFGLAREWH+TT+MSAAGTYAWMAPEV
Sbjct: 234 LVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEV 293
Query: 321 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 380
I+AS FSKGSDVWS+GVLLWELLTGEVP+RGID LAVAYGVA+NKL LPIPSTCPEPFA+
Sbjct: 294 IKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQ 353
Query: 381 LMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAK 440
LM DCW DPH RP F +IL QL +E EMP+DSFH +Q+ WK EIQ +FD+LRAK
Sbjct: 354 LMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAK 413
Query: 441 EKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKK 500
EKEL + EEELTRAA +Q++Q E LRRRE LA+ E+++ EREL +++ Q+ +E+P V++
Sbjct: 414 EKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRR 473
Query: 501 RKGKFRKSRLKLKD-GNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRL 559
R+G F++S+L+ +D G RIS+P DF+H+ TVQASP +D+R+++ P SPT PR
Sbjct: 474 RRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVF--EVGPGDSPT-FPRF 530
Query: 560 RAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQR 619
RAIQL P E + WGR S E+ E+RA WGP + E +G S R
Sbjct: 531 RAIQLEPAEPGQAWGRQSPRRLEDSSNGERRA----CWAWGPSSPKPGEAQNGRRRS--R 584
Query: 620 REKANG-LSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTS----LME 674
++A L + SP ++G S P K P PA G +S L++
Sbjct: 585 MDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRP--VPAERGSSSGTPKLIQ 642
Query: 675 MALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFP 718
ALL + ++ + D + PG SP+ P P
Sbjct: 643 RALLRGTALL-ASLGLGRDLQPPGGPGRERGESPTTPPTPTPAP 685
Score = 43.9 bits (102), Expect = 9e-04
Identities = 70/265 (26%), Positives = 87/265 (32%), Gaps = 77/265 (29%)
Query: 865 RSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPS 924
RS DE Y + ++ PL + P +N P SL P P++
Sbjct: 582 RSRMDEATWY---LDSDDSSPLGSPSTPPALN------GNPPRPSLEPEEPKRPVPAERG 632
Query: 925 SHRRTPS--DGALKPETLLASRSPSSNGLSPSPGAGMLK--------TPSPSRDPGEFPR 974
S TP AL T L + L P G G + TP+P+ P E P
Sbjct: 633 SSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPP- 691
Query: 975 LPDPNVVF-------PPTP-------------------RRWNTQQDSTLERPK------- 1001
P P + F PPTP RR + T+ P
Sbjct: 692 -PSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAP 750
Query: 1002 ---------TLEFLPRPRPSANRQRLDPWWFVS----PSHARSTSPANSSSTETPSNLDS 1048
L + RPRPS R R+DPW FVS PS S PA + T
Sbjct: 751 GTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSD 810
Query: 1049 CFASSSSTVEERPGLPALLPFQAGP 1073
F S P PFQ GP
Sbjct: 811 PFWDS----------PPANPFQGGP 825
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 246 bits (629), Expect = 7e-65
Identities = 144/369 (39%), Positives = 214/369 (57%), Gaps = 26/369 (7%)
Query: 136 LLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
L E+ F E+ + +G G G V+ + G+EVAVK R + DI K
Sbjct: 117 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHL 165
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMN 254
LKHPNII +GVC + P C++MEF G L VL +G+ + P +LV+W++ IA GMN
Sbjct: 166 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 225
Query: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH-RTTKMSAAGTY 313
YLH + IIHRDLKS N+LI + ++KI+DFG ++E ++TKMS AGT
Sbjct: 226 YLH---LHKIIHRDLKSPNMLITY--------DDVVKISDFGTSKELSDKSTKMSFAGTV 274
Query: 314 AWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 373
AWMAPEVIR S+ D+WS+GV+LWELLTGE+P++ +D A+ +GV N L LP+PS+
Sbjct: 275 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSS 334
Query: 374 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEM 433
CP+ F L+ CWN P +RPSF IL L I + P++++ Q W+ E++
Sbjct: 335 CPDGFKILLRQCWNSKPRNRPSFRQILLHL-DIASADVLSTPQETYFKSQAEWREEVKLH 393
Query: 434 FDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQ 493
F++++++ L EEEL ++ +R + ER + L ELN ++ QL
Sbjct: 394 FEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLER-ANNLYMELNALMLQLEL 452
Query: 494 EKPRVKKRK 502
++ + +R+
Sbjct: 453 KERELLRRE 461
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 244 bits (624), Expect = 3e-64
Identities = 142/373 (38%), Positives = 215/373 (57%), Gaps = 27/373 (7%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
E+ F E++ + +G G G V+ + +EVA+K R + DI K
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRK 210
Query: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 256
LKHPNIIA +GVC + P C++ME+ G L VL +G++I P +LV+W+ IA GMNYL
Sbjct: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 270
Query: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH-RTTKMSAAGTYAW 315
H + IIHRDLKS N+L+ +KI+DFG ++E ++TKMS AGT AW
Sbjct: 271 H---LHKIIHRDLKSPNVLVTH--------TDAVKISDFGTSKELSDKSTKMSFAGTVAW 319
Query: 316 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 375
MAPEVIR S+ D+WS+GV+LWELLTGE+P++ +D A+ +GV N L LP+PSTCP
Sbjct: 320 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
Query: 376 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 435
+ F LM+ W P +RPSF L L I + P++++ Q W+ E+++ F+
Sbjct: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHL-DIASADVLATPQETYFKSQAEWREEVKKHFE 438
Query: 436 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQL-CQE 494
+++++ + +EEL R ++ +R + ER + L EL+ I+ QL +E
Sbjct: 439 KIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLER-ANNLYMELSAIMLQLEMRE 497
Query: 495 KPRVKKRKGKFRK 507
K +K+ + +K
Sbjct: 498 KELIKREQAVEKK 510
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 228 bits (580), Expect = 3e-59
Identities = 135/344 (39%), Positives = 195/344 (56%), Gaps = 32/344 (9%)
Query: 137 LEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKL 194
++I F +L E G G FG VYRA WI EVAVK + + +EA++
Sbjct: 9 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKK------------LLKIEKEAEI 56
Query: 195 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIAR 251
++L H NII GV L+ PN +V E+A G L ++ R + D ++ WA +A+
Sbjct: 57 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 116
Query: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 311
GM+YLH EA V +IHRDLKS N++I ++ +LKI DFG +R + TT MS G
Sbjct: 117 GMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVG 168
Query: 312 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 371
T+ WMAPEVI++ S+ D +SYGV+LWE+LT EVPF+G++GL VA+ V L IP
Sbjct: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIP 228
Query: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQ 431
S+CP FA+L+ CW D RPSF I+ L ++ +SF + W+ EI+
Sbjct: 229 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIE 288
Query: 432 EMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAER 475
++L+ E++L E+EL K +E L+ EQ+L E+
Sbjct: 289 ATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 228 bits (580), Expect = 3e-59
Identities = 135/344 (39%), Positives = 195/344 (56%), Gaps = 32/344 (9%)
Query: 137 LEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKL 194
++I F +L E G G FG VYRA WI EVAVK + + +EA++
Sbjct: 9 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKK------------LLKIEKEAEI 56
Query: 195 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIAR 251
++L H NII GV L+ PN +V E+A G L ++ R + D ++ WA +A+
Sbjct: 57 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 116
Query: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 311
GM+YLH EA V +IHRDLKS N++I ++ +LKI DFG +R + TT MS G
Sbjct: 117 GMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVG 168
Query: 312 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 371
T+ WMAPEVI++ S+ D +SYGV+LWE+LT EVPF+G++GL VA+ V L IP
Sbjct: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIP 228
Query: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQ 431
S+CP FA+L+ CW D RPSF I+ L ++ +SF + W+ EI+
Sbjct: 229 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIE 288
Query: 432 EMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAER 475
++L+ E++L E+EL K +E L+ EQ+L E+
Sbjct: 289 ATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 166 bits (420), Expect = 1e-40
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)
Query: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168
T +A SS GE P Q+L EID+ E+ +EE++G G FG V +A W +V
Sbjct: 3 TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228
A+K + + I +RQ +++ HPNI+ L G CL +CLVME+A GG L
Sbjct: 61 AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
Query: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
VL G P ++W +Q ++G+ YLH +IHRDLK N+L++
Sbjct: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
Query: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344
+LKI DFG A + +T + G+ AWMAPEV S +S+ DV+S+G++LWE++T
Sbjct: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
PF I G A A+ N P+ P+P LM CW+ DP RPS I+ +
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
Query: 404 T 404
T
Sbjct: 285 T 285
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 166 bits (420), Expect = 1e-40
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)
Query: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168
T +A SS GE P Q+L EID+ E+ +EE++G G FG V +A W +V
Sbjct: 3 TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228
A+K + + I +RQ +++ HPNI+ L G CL +CLVME+A GG L
Sbjct: 61 AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
Query: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
VL G P ++W +Q ++G+ YLH +IHRDLK N+L++
Sbjct: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
Query: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344
+LKI DFG A + +T + G+ AWMAPEV S +S+ DV+S+G++LWE++T
Sbjct: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
PF I G A A+ N P+ P+P LM CW+ DP RPS I+ +
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
Query: 404 T 404
T
Sbjct: 285 T 285
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 166 bits (420), Expect = 1e-40
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)
Query: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168
T +A SS GE P Q+L EID+ E+ +EE++G G FG V +A W +V
Sbjct: 3 TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228
A+K + + I +RQ +++ HPNI+ L G CL +CLVME+A GG L
Sbjct: 61 AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
Query: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
VL G P ++W +Q ++G+ YLH +IHRDLK N+L++
Sbjct: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
Query: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344
+LKI DFG A + +T + G+ AWMAPEV S +S+ DV+S+G++LWE++T
Sbjct: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
PF I G A A+ N P+ P+P LM CW+ DP RPS I+ +
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
Query: 404 T 404
T
Sbjct: 285 T 285
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 166 bits (420), Expect = 1e-40
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)
Query: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168
T +A SS GE P Q+L EID+ E+ +EE++G G FG V +A W +V
Sbjct: 3 TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228
A+K + + I +RQ +++ HPNI+ L G CL +CLVME+A GG L
Sbjct: 61 AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
Query: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
VL G P ++W +Q ++G+ YLH +IHRDLK N+L++
Sbjct: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
Query: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344
+LKI DFG A + +T + G+ AWMAPEV S +S+ DV+S+G++LWE++T
Sbjct: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
PF I G A A+ N P+ P+P LM CW+ DP RPS I+ +
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
Query: 404 T 404
T
Sbjct: 285 T 285
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 149 bits (376), Expect = 1e-35
Identities = 93/279 (33%), Positives = 145/279 (51%), Gaps = 24/279 (8%)
Query: 139 IDFAELTLEEIIGIGGFGKVYRAFWIG-DEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
ID +ELT + IG G FG V+ +W+ D+VA+K R + + E+ +EA++
Sbjct: 358 IDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG-----AMSEEDFIEEAEVMMK 412
Query: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNY 255
L HP ++ L GVCL++ +CLV EF G L+ L +R + L+ + + GM Y
Sbjct: 413 LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAY 472
Query: 256 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT--- 312
L + +IHRDL + N L+ + N+++K++DFG+ R S+ GT
Sbjct: 473 LEEAC---VIHRDLAARNCLVGE--------NQVIKVSDFGMTRFVLDDQYTSSTGTKFP 521
Query: 313 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIP 371
W +PEV S +S SDVWS+GVL+WE+ + G++P+ V ++ L P
Sbjct: 522 VKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG-FRLYKP 580
Query: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESG 410
++M CW P RP+F+ +L QL I ESG
Sbjct: 581 RLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 619
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 146 bits (368), Expect = 1e-34
Identities = 97/283 (34%), Positives = 146/283 (51%), Gaps = 34/283 (12%)
Query: 131 YPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDE-VAVKAARH---DPDEDISQTIE 186
Y + EID + L + +G G FG+V+ W VAVK + DP++ +
Sbjct: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL----- 275
Query: 187 NVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILV 243
+EA++ L+HP +I L VC E + ++ E R G L L +G +I V
Sbjct: 276 ---REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332
Query: 244 NWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR 303
+ A Q+A GM YL IHRDL + N+L+ + + I K+ DFGLAR +
Sbjct: 333 DMAAQVASGMAYLESRNY---IHRDLAARNVLVGE--------HNIYKVADFGLARVFKV 381
Query: 304 TTKMSAAGTYA------WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLA 356
+ + W APE IR++ FS SDVWS+G+LL+E++T G++P+ G+ G
Sbjct: 382 DNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQ 441
Query: 357 VAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNI 399
V +A N LP PS CP+ F +M +CWN +P RP+F +
Sbjct: 442 VIQMLAQN-YRLPQPSNCPQQFYNIMLECWNAEPKERPTFETL 483
Score = 40.8 bits (94), Expect = 0.007
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 14/65 (21%)
Query: 56 YWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWW---------TGQLNQRVGIF 106
Y+ A+F+Y+A ++L+ R GD ++VL + EGWW G Q G
Sbjct: 46 YFVALFDYQARTAEDLSFRAGDKLQVLD-----TLHEGWWFARHLEKRRDGSSQQLQGYI 100
Query: 107 PSNYV 111
PSNYV
Sbjct: 101 PSNYV 105
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 144 bits (364), Expect = 4e-34
Identities = 99/296 (33%), Positives = 146/296 (49%), Gaps = 29/296 (9%)
Query: 123 PGGEDPSCY---PPIQLLEIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDP 177
P P+ Y P E++ ++T++ +G G +G+VY W VAVK + D
Sbjct: 218 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 277
Query: 178 DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSG 234
E +E +EA + +KHPN++ L GVC +EP ++ EF G L R +
Sbjct: 278 ME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR 332
Query: 235 KRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITD 294
+ + +L+ A QI+ M YL + IHRDL + N L+ + N ++K+ D
Sbjct: 333 QEVNAVVLLYMATQISSAMEYLEKKNF---IHRDLAARNCLVGE--------NHLVKVAD 381
Query: 295 FGLAREWHRTTKMSAAGT---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFR 350
FGL+R T + AG W APE + + FS SDVW++GVLLWE+ T G P+
Sbjct: 382 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP 441
Query: 351 GIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 406
GID L+ Y + + P CPE +LM CW +P RPSF I T+
Sbjct: 442 GID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 496
Score = 36.2 bits (82), Expect = 0.18
Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 8/104 (7%)
Query: 10 CLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGED 69
C A P D G E + GP E + + A++++ A+G++
Sbjct: 23 CYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNL----FVALYDFVASGDN 78
Query: 70 ELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTP 113
L++ G+ + VL + +G+ W Q G PSNY+TP
Sbjct: 79 TLSITKGEKLRVLGYNH--NGE--WCEAQTKNGQGWVPSNYITP 118
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 144 bits (364), Expect = 4e-34
Identities = 99/296 (33%), Positives = 146/296 (49%), Gaps = 29/296 (9%)
Query: 123 PGGEDPSCY---PPIQLLEIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDP 177
P P+ Y P E++ ++T++ +G G +G+VY W VAVK + D
Sbjct: 237 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 296
Query: 178 DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSG 234
E +E +EA + +KHPN++ L GVC +EP ++ EF G L R +
Sbjct: 297 ME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR 351
Query: 235 KRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITD 294
+ + +L+ A QI+ M YL + IHRDL + N L+ + N ++K+ D
Sbjct: 352 QEVNAVVLLYMATQISSAMEYLEKKNF---IHRDLAARNCLVGE--------NHLVKVAD 400
Query: 295 FGLAREWHRTTKMSAAGT---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFR 350
FGL+R T + AG W APE + + FS SDVW++GVLLWE+ T G P+
Sbjct: 401 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP 460
Query: 351 GIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 406
GID L+ Y + + P CPE +LM CW +P RPSF I T+
Sbjct: 461 GID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 515
Score = 33.9 bits (76), Expect = 0.89
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Query: 15 AAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLR 74
A P D G E + GP E + + A++++ A+G++ L++
Sbjct: 47 ALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNL----FVALYDFVASGDNTLSIT 102
Query: 75 LGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTP 113
G+ + VL + +G+ W Q G PSNY+TP
Sbjct: 103 KGEKLRVLGYNH--NGE--WCEAQTKNGQGWVPSNYITP 137
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 142 bits (358), Expect = 2e-33
Identities = 97/286 (33%), Positives = 136/286 (47%), Gaps = 38/286 (13%)
Query: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFA 196
++ +L L E IG G FG+V+ D VAVK+ R D+ QEA++
Sbjct: 428 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKF---LQEARILK 484
Query: 197 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQIARGMN 254
HPNI+ L GVC ++ + +VME +GG L G R+ L+ A GM
Sbjct: 485 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 544
Query: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 314
YL + IHRDL + N L+ +K +LKI+DFG++RE A G YA
Sbjct: 545 YLESKCC---IHRDLAARNCLVTEK--------NVLKISDFGMSRE-------EADGVYA 586
Query: 315 -----------WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVA 362
W APE + +S SDVWS+G+LLWE + G P+ + V
Sbjct: 587 ASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE 646
Query: 363 MNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
LP P CP+ +LME CW +P RPSF+ I +L +I +
Sbjct: 647 KGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 691
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 142 bits (358), Expect = 2e-33
Identities = 97/286 (33%), Positives = 136/286 (47%), Gaps = 38/286 (13%)
Query: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFA 196
++ +L L E IG G FG+V+ D VAVK+ R D+ QEA++
Sbjct: 486 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKF---LQEARILK 542
Query: 197 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQIARGMN 254
HPNI+ L GVC ++ + +VME +GG L G R+ L+ A GM
Sbjct: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 602
Query: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 314
YL + IHRDL + N L+ +K +LKI+DFG++RE A G YA
Sbjct: 603 YLESKCC---IHRDLAARNCLVTEK--------NVLKISDFGMSRE-------EADGVYA 644
Query: 315 -----------WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVA 362
W APE + +S SDVWS+G+LLWE + G P+ + V
Sbjct: 645 ASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE 704
Query: 363 MNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
LP P CP+ +LME CW +P RPSF+ I +L +I +
Sbjct: 705 KGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 749
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 142 bits (358), Expect = 2e-33
Identities = 97/286 (33%), Positives = 136/286 (47%), Gaps = 38/286 (13%)
Query: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFA 196
++ +L L E IG G FG+V+ D VAVK+ R D+ QEA++
Sbjct: 498 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKF---LQEARILK 554
Query: 197 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQIARGMN 254
HPNI+ L GVC ++ + +VME +GG L G R+ L+ A GM
Sbjct: 555 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 614
Query: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 314
YL + IHRDL + N L+ +K +LKI+DFG++RE A G YA
Sbjct: 615 YLESKCC---IHRDLAARNCLVTEK--------NVLKISDFGMSRE-------EADGVYA 656
Query: 315 -----------WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVA 362
W APE + +S SDVWS+G+LLWE + G P+ + V
Sbjct: 657 ASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE 716
Query: 363 MNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
LP P CP+ +LME CW +P RPSF+ I +L +I +
Sbjct: 717 KGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 761
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 142 bits (358), Expect = 2e-33
Identities = 97/286 (33%), Positives = 136/286 (47%), Gaps = 38/286 (13%)
Query: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFA 196
++ +L L E IG G FG+V+ D VAVK+ R D+ QEA++
Sbjct: 556 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKF---LQEARILK 612
Query: 197 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQIARGMN 254
HPNI+ L GVC ++ + +VME +GG L G R+ L+ A GM
Sbjct: 613 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 672
Query: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 314
YL + IHRDL + N L+ +K +LKI+DFG++RE A G YA
Sbjct: 673 YLESKCC---IHRDLAARNCLVTEK--------NVLKISDFGMSRE-------EADGVYA 714
Query: 315 -----------WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVA 362
W APE + +S SDVWS+G+LLWE + G P+ + V
Sbjct: 715 ASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE 774
Query: 363 MNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
LP P CP+ +LME CW +P RPSF+ I +L +I +
Sbjct: 775 KGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 819
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 137 bits (344), Expect = 7e-32
Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 27/294 (9%)
Query: 126 EDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDE-----VAVKAARHDPDED 180
ED P + EI + L IG G FG V++ ++ E VA+K ++ +
Sbjct: 426 EDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS 485
Query: 181 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD 240
+ E QEA HP+I+ L GV + P + ++ME G L L ++ D
Sbjct: 486 VR---EKFLQEALTMRQFDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLD 541
Query: 241 I--LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA 298
+ L+ +A Q++ + YL + V HRD+ + N+L+ SN +K+ DFGL+
Sbjct: 542 LASLILYAYQLSTALAYLESKRFV---HRDIAARNVLVS--------SNDCVKLGDFGLS 590
Query: 299 REWHRTTKMSAAG---TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDG 354
R +T A+ WMAPE I F+ SDVW +GV +WE+L G PF+G+
Sbjct: 591 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKN 650
Query: 355 LAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
V G N LP+P CP LM CW DP RP FT + QL+TI E
Sbjct: 651 NDVI-GRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 703
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 137 bits (344), Expect = 7e-32
Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 27/294 (9%)
Query: 126 EDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDE-----VAVKAARHDPDED 180
ED P + EI + L IG G FG V++ ++ E VA+K ++ +
Sbjct: 404 EDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS 463
Query: 181 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD 240
+ E QEA HP+I+ L GV + P + ++ME G L L ++ D
Sbjct: 464 VR---EKFLQEALTMRQFDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLD 519
Query: 241 I--LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA 298
+ L+ +A Q++ + YL + V HRD+ + N+L+ SN +K+ DFGL+
Sbjct: 520 LASLILYAYQLSTALAYLESKRFV---HRDIAARNVLVS--------SNDCVKLGDFGLS 568
Query: 299 REWHRTTKMSAAG---TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDG 354
R +T A+ WMAPE I F+ SDVW +GV +WE+L G PF+G+
Sbjct: 569 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKN 628
Query: 355 LAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
V G N LP+P CP LM CW DP RP FT + QL+TI E
Sbjct: 629 NDVI-GRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 681
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 135 bits (341), Expect = 2e-31
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 26/268 (9%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
E++ ++T++ +G G +G+VY W VAVK + D E +E +EA +
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVM 321
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARG 252
+KHPN++ L GVC EP +V E+ G L R + + + +L+ A QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 253 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 312
M YL + IHRDL + N L+ + N ++K+ DFGL+R T + AG
Sbjct: 382 MEYLEKKNF---IHRDLAARNCLVGE--------NHVVKVADFGLSRLMTGDTYTAHAGA 430
Query: 313 ---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLAL 368
W APE + + FS SDVW++GVLLWE+ T G P+ GID L+ Y + +
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRM 489
Query: 369 PIPSTCPEPFAKLMEDCWNPDPHSRPSF 396
P CP +LM CW P RPSF
Sbjct: 490 EQPEGCPPKVYELMRACWKWSPADRPSF 517
Score = 34.3 bits (77), Expect = 0.68
Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 879 SPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLT-TPSQP------SSHRRTPS 931
SP +A P+ P THN V V + P TP V L T SQ S H+ T S
Sbjct: 900 SPAKAAPVLPTTHNHKVPVLI-----SPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSS 954
Query: 932 DGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFP 973
+P + +P P P +L+ PS DP E P
Sbjct: 955 GDKDRPRRVKPKCAP-----PPPPVMRLLQHPSICSDPTEEP 991
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 135 bits (341), Expect = 2e-31
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 26/268 (9%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
E++ ++T++ +G G +G+VY W VAVK + D E +E +EA +
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVM 336
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARG 252
+KHPN++ L GVC EP +V E+ G L R + + + +L+ A QI+
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396
Query: 253 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 312
M YL + IHRDL + N L+ + N ++K+ DFGL+R T + AG
Sbjct: 397 MEYLEKKNF---IHRDLAARNCLVGE--------NHVVKVADFGLSRLMTGDTYTAHAGA 445
Query: 313 ---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLAL 368
W APE + + FS SDVW++GVLLWE+ T G P+ GID L+ Y + +
Sbjct: 446 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRM 504
Query: 369 PIPSTCPEPFAKLMEDCWNPDPHSRPSF 396
P CP +LM CW P RPSF
Sbjct: 505 EQPEGCPPKVYELMRACWKWSPADRPSF 532
Score = 34.3 bits (77), Expect = 0.68
Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 879 SPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLT-TPSQP------SSHRRTPS 931
SP +A P+ P THN V V + P TP V L T SQ S H+ T S
Sbjct: 915 SPAKAAPVLPTTHNHKVPVLI-----SPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSS 969
Query: 932 DGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFP 973
+P + +P P P +L+ PS DP E P
Sbjct: 970 GDKDRPRRVKPKCAP-----PPPPVMRLLQHPSICSDPTEEP 1006
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 135 bits (341), Expect = 2e-31
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 26/268 (9%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
E++ ++T++ +G G +G+VY W VAVK + D E +E +EA +
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVM 315
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARG 252
+KHPN++ L GVC EP +V E+ G L R + + + +L+ A QI+
Sbjct: 316 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 375
Query: 253 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 312
M YL + IHRDL + N L+ + N ++K+ DFGL+R T + AG
Sbjct: 376 MEYLEKKNF---IHRDLAARNCLVGE--------NHVVKVADFGLSRLMTGDTYTAHAGA 424
Query: 313 ---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLAL 368
W APE + + FS SDVW++GVLLWE+ T G P+ GID L+ Y + +
Sbjct: 425 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRM 483
Query: 369 PIPSTCPEPFAKLMEDCWNPDPHSRPSF 396
P CP +LM CW P RPSF
Sbjct: 484 EQPEGCPPKVYELMRACWKWSPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 135 bits (341), Expect = 2e-31
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 26/268 (9%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
E++ ++T++ +G G +G+VY W VAVK + D E +E +EA +
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVM 321
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARG 252
+KHPN++ L GVC EP +V E+ G L R + + + +L+ A QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 253 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 312
M YL + IHRDL + N L+ + N ++K+ DFGL+R T + AG
Sbjct: 382 MEYLEKKNF---IHRDLAARNCLVGE--------NHVVKVADFGLSRLMTGDTYTAHAGA 430
Query: 313 ---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLAL 368
W APE + + FS SDVW++GVLLWE+ T G P+ GID L+ Y + +
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRM 489
Query: 369 PIPSTCPEPFAKLMEDCWNPDPHSRPSF 396
P CP +LM CW P RPSF
Sbjct: 490 EQPEGCPPKVYELMRACWKWSPADRPSF 517
Score = 34.3 bits (77), Expect = 0.68
Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 879 SPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLT-TPSQP------SSHRRTPS 931
SP +A P+ P THN V V + P TP V L T SQ S H+ T S
Sbjct: 797 SPAKAAPVLPTTHNHKVPVLI-----SPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSS 851
Query: 932 DGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFP 973
+P + +P P P +L+ PS DP E P
Sbjct: 852 GDKDRPRRVKPKCAP-----PPPPVMRLLQHPSICSDPTEEP 888
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 135 bits (341), Expect = 2e-31
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 26/268 (9%)
Query: 138 EIDFAELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLF 195
E++ ++T++ +G G +G+VY W VAVK + D E +E +EA +
Sbjct: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME-----VEEFLKEAAVM 300
Query: 196 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARG 252
+KHPN++ L GVC EP +V E+ G L R + + + +L+ A QI+
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 253 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 312
M YL + IHRDL + N L+ + N ++K+ DFGL+R T + AG
Sbjct: 361 MEYLEKKNF---IHRDLAARNCLVGE--------NHVVKVADFGLSRLMTGDTYTAHAGA 409
Query: 313 ---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLAL 368
W APE + + FS SDVW++GVLLWE+ T G P+ GID L+ Y + +
Sbjct: 410 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYRM 468
Query: 369 PIPSTCPEPFAKLMEDCWNPDPHSRPSF 396
P CP +LM CW P RPSF
Sbjct: 469 EQPEGCPPKVYELMRACWKWSPADRPSF 496
Score = 34.3 bits (77), Expect = 0.68
Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 17/102 (16%)
Query: 879 SPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLT-TPSQP------SSHRRTPS 931
SP +A P+ P THN V V + P TP V L T SQ S H+ T S
Sbjct: 879 SPAKAAPVLPTTHNHKVPVLI-----SPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSS 933
Query: 932 DGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFP 973
+P + +P P P +L+ PS DP E P
Sbjct: 934 GDKDRPRRVKPKCAP-----PPPPVMRLLQHPSICSDPTEEP 970
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 135 bits (341), Expect = 2e-31
Identities = 87/269 (32%), Positives = 135/269 (50%), Gaps = 24/269 (8%)
Query: 145 TLEEIIGIGGFGKVYRAFWI-GDEVAVKAARHDPDEDISQTIE--NVRQEAKLFAMLKHP 201
T EI+G G +G VY G +AVK D ++ E +++E L LKH
Sbjct: 1062 TKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHV 1121
Query: 202 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSG-KRIPPDILVNWAVQIARGMNYLHDEA 260
NI+A G CL+E + + MEF GG ++ +++ +P + + QI +G+ YLH+
Sbjct: 1122 NIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENC 1181
Query: 261 IVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--W------HRTTKMSAAGT 312
+V HRD+K +N++++ I+K+ DFG AR W H S GT
Sbjct: 1182 VV---HRDIKGNNVMLMP--------TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGT 1230
Query: 313 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNK-LALPIP 371
WMAPEVI S + + SD+WS G ++E+ TG+ P +D +A + + ++ L P+P
Sbjct: 1231 PYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP 1290
Query: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNIL 400
E A + C D H RPS +L
Sbjct: 1291 DHFSENAADFVRMCLTRDQHERPSALQLL 1319
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 135 bits (341), Expect = 2e-31
Identities = 87/269 (32%), Positives = 135/269 (50%), Gaps = 24/269 (8%)
Query: 145 TLEEIIGIGGFGKVYRAFWI-GDEVAVKAARHDPDEDISQTIE--NVRQEAKLFAMLKHP 201
T EI+G G +G VY G +AVK D ++ E +++E L LKH
Sbjct: 244 TKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHV 303
Query: 202 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSG-KRIPPDILVNWAVQIARGMNYLHDEA 260
NI+A G CL+E + + MEF GG ++ +++ +P + + QI +G+ YLH+
Sbjct: 304 NIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENC 363
Query: 261 IVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--W------HRTTKMSAAGT 312
+V HRD+K +N++++ I+K+ DFG AR W H S GT
Sbjct: 364 VV---HRDIKGNNVMLMP--------TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGT 412
Query: 313 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNK-LALPIP 371
WMAPEVI S + + SD+WS G ++E+ TG+ P +D +A + + ++ L P+P
Sbjct: 413 PYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP 472
Query: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNIL 400
E A + C D H RPS +L
Sbjct: 473 DHFSENAADFVRMCLTRDQHERPSALQLL 501
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 135 bits (341), Expect = 2e-31
Identities = 95/277 (34%), Positives = 142/277 (51%), Gaps = 22/277 (7%)
Query: 134 IQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAK 193
+QL EI+F EIIG G FGKVY+ VA+K R + S ++ +E
Sbjct: 458 LQLSEIEF-----HEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-VDMFCREVS 511
Query: 194 LFAMLKHPNIIALRGVCLKEPN-LCLVMEFARGGPLNRVLSGKRIPPDILVNW--AVQIA 250
+ L HP +I G CL +P+ +V ++ GG L +L ++ D+ AV +A
Sbjct: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVA 571
Query: 251 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKM 307
+GM YLH+ PIIHRDL S NIL+ E+G + DFG +R
Sbjct: 572 KGMEYLHN-LTQPIIHRDLNSHNILLY---EDGHAV-----VADFGESRFLQSLDEDNMT 622
Query: 308 SAAGTYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKL 366
G WMAPEV + + ++ +DV+SY + LWE+LTGE+PF + A A +A + +
Sbjct: 623 KQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI 682
Query: 367 ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
PI + P+P + L+ WN P RP F+ ++ +L
Sbjct: 683 RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL 719
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,873,928
Number of Sequences: 37866
Number of extensions: 3092924
Number of successful extensions: 23141
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 710
Number of HSP's successfully gapped in prelim test: 914
Number of HSP's that attempted gapping in prelim test: 15715
Number of HSP's gapped (non-prelim): 5328
length of query: 1118
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1005
effective length of database: 13,968,660
effective search space: 14038503300
effective search space used: 14038503300
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.