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Search of human proteins with 5174547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174547 mitogen-activated protein kinase kinase kinase 5
[Homo sapiens]
(1374 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 2742 0.0
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 1103 0.0
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 868 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 193 1e-48
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 193 1e-48
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 168 3e-41
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 168 3e-41
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 164 5e-40
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 164 5e-40
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 164 7e-40
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 162 2e-39
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 147 7e-35
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 144 6e-34
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 144 6e-34
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 144 6e-34
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 144 6e-34
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 144 6e-34
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 144 6e-34
gi|32483399 p21-activated kinase 2 [Homo sapiens] 143 1e-33
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 143 1e-33
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 140 6e-33
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 139 1e-32
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 139 2e-32
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 139 2e-32
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 139 2e-32
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 137 5e-32
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 137 5e-32
gi|93004081 polo-like kinase 2 [Homo sapiens] 136 1e-31
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 135 4e-31
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 132 2e-30
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 2742 bits (7108), Expect = 0.0
Identities = 1374/1374 (100%), Positives = 1374/1374 (100%)
Query: 1 MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA 60
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
Sbjct: 1 MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA 60
Query: 61 AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC 120
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
Sbjct: 61 AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC 120
Query: 121 ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN 180
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
Sbjct: 121 ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN 180
Query: 181 IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP 240
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
Sbjct: 181 IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP 240
Query: 241 NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR 300
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
Sbjct: 241 NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR 300
Query: 301 QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN 360
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
Sbjct: 301 QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN 360
Query: 361 RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK 420
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
Sbjct: 361 RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK 420
Query: 421 KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF 480
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
Sbjct: 421 KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF 480
Query: 481 FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD 540
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
Sbjct: 481 FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD 540
Query: 541 FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH 600
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
Sbjct: 541 FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH 600
Query: 601 EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS 660
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
Sbjct: 601 EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS 660
Query: 661 TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ 720
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
Sbjct: 661 TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ 720
Query: 721 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI 780
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
Sbjct: 721 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI 780
Query: 781 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT 840
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
Sbjct: 781 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT 840
Query: 841 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH 900
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
Sbjct: 841 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH 900
Query: 901 PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE 960
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
Sbjct: 901 PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE 960
Query: 961 YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI 1020
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
Sbjct: 961 YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI 1020
Query: 1021 PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP 1080
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
Sbjct: 1021 PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP 1080
Query: 1081 KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK 1140
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
Sbjct: 1081 KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK 1140
Query: 1141 VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE 1200
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
Sbjct: 1141 VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE 1200
Query: 1201 QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV 1260
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
Sbjct: 1201 QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV 1260
Query: 1261 RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN 1320
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
Sbjct: 1261 RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN 1320
Query: 1321 GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT 1374
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
Sbjct: 1321 GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT 1374
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 1103 bits (2853), Expect = 0.0
Identities = 623/1344 (46%), Positives = 834/1344 (62%), Gaps = 96/1344 (7%)
Query: 52 GSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQL-----V 106
GS W A A G A A GRG + SR +V YV+ Q L
Sbjct: 14 GSCWQDPLAVALSRGRQLA-----APPGRGCA---RSRPLSVVYVLTREPQPGLEPREGT 65
Query: 107 VAESEALQSLREACETVGAT-----LETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFR 161
AE L+ LREAC V L +L FG L+ G+T LD FYNAD+ V+E+S +
Sbjct: 66 EAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLV 125
Query: 162 QPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHN 221
QPSLFYHLGVRESFSM NN++L + LQ+L+E + QKN+ C G+YT +PY++T
Sbjct: 126 QPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATG 185
Query: 222 KVYCCDSSFMKGLTE-LMQPNF--ELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILN 278
+V C D+ ++GL + L+Q E LL PLV R +LL+ S YFRE+I
Sbjct: 186 RVLCGDAGLLRGLADGLVQAGVGTEALL----TPLVGRLARLLEATPTDSCGYFRETIRR 241
Query: 279 DIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLE 338
DIR+AR ++G +L ELAR+++R+D++E+L+ DI++NLLLSYRD+QDY +I++LVETL+
Sbjct: 242 DIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQ 301
Query: 339 KLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYK 398
LPT D+A H+V FHY FALNRRN PGDRAKAL +++P+VQ EG VA D+YC+ GRIYK
Sbjct: 302 ALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYK 361
Query: 399 DMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVK 458
DMF S F D R+ W++KAF+ EP+L SGIN AVLL+AAG FE S ELR +G+K
Sbjct: 362 DMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMK 421
Query: 459 LSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETI 518
L LL +KG +EK+Q YW+VGF+LGA +LAND +V+ A+E+L+KL P WYL S++ET
Sbjct: 422 LGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETF 481
Query: 519 LIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVV----RFPVLILEPTKIYQPSY 574
L+Y+HF + T E P FW+ FL+++ + T + VL+LE K+ P+
Sbjct: 482 LLYQHF-RPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK 540
Query: 575 LSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQ 634
L + T+++ + P+ + W F +S+ GVS SK +ERCCFLY L + D Q
Sbjct: 541 LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ 600
Query: 635 IYFCTELHCKKFFEMVNT--ITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYG 692
+ F + HC+ F ++ + EE + ++LE+DYEY E G+R+VLGKGTYG
Sbjct: 601 LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG 660
Query: 693 IVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKI 752
+VYAGRD +VRIAIKEIPERDSR+SQPLHEEIALH+ L+HKNIV+YLGS S+ G++KI
Sbjct: 661 VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI 720
Query: 753 FMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLIN 812
FME+VPGGSLS+LLRS WGPLKDNE TI FYT+QIL+GL YLHDN IVHRDIKGDNVLIN
Sbjct: 721 FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN 780
Query: 813 TYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTII 872
T+SG+LKISDFGTSKRLAGI PCTETFTGTLQYMAPEIID+GPRGYGKAADIWSLGCT+I
Sbjct: 781 TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI 840
Query: 873 EMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDL 932
EMATG+PPF+ELG PQAAMF+VGM+KVHP +P S+SAEA+AF+L+ FEPDP RA A L
Sbjct: 841 EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL 900
Query: 933 LVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELK 992
L D FL QP + S S + P P D S+S S + T+ +
Sbjct: 901 LGDPFL---------QPGKRSRSPSSPRH-----APRP---SDAPSASPTPSANSTTQSQ 943
Query: 993 VDPF--SFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSER 1050
P + S +R + T L +P+E + P SPEE SG +L ++S+R
Sbjct: 944 TFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEE--PASPEE-SSGLSLLHQESKR 1000
Query: 1051 RATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTL 1110
RA L +L ++ + NL + Q + +L H+ L+ L + + +R+ +A L
Sbjct: 1001 RAMLAAVLEQELPALAENLHQEQKQ-EQGARLGRNHVEELLRCLGAHIHTPNRRQLAQEL 1059
Query: 1111 SKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITIL 1170
L+ L G + + LF F DAV ++LR I+PHWMF LDS++ +AV+ A+ +L
Sbjct: 1060 RALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVL 1119
Query: 1171 VPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTV 1230
PE+ E+ + E+L E D ++ P Q S +
Sbjct: 1120 GPEVE------KEAVSPRSEELSNEGDSQQSPGQQ----------------------SPL 1151
Query: 1231 SHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQP 1290
+ + L VQL ++ ET+RL E L KE+E QAL+ RA++ ++E + L +P
Sbjct: 1152 PVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEP 1211
Query: 1291 IEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLK 1350
+ D L WL+ D TI L +TL +L Y TRDDL
Sbjct: 1212 -------------PTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLI 1258
Query: 1351 CLRLRGGMLCTLWKAIIDFRNKQT 1374
R+RGGM+C +W+AI+ R T
Sbjct: 1259 YTRIRGGMVCRIWRAILAQRAGST 1282
>gi|121583542 mitogen-activated protein kinase kinase kinase 15 [Homo
sapiens]
Length = 788
Score = 868 bits (2243), Expect = 0.0
Identities = 458/766 (59%), Positives = 564/766 (73%), Gaps = 49/766 (6%)
Query: 613 SISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNT-ITEEKGRSTE-EGDCESDL 670
S+SKF+ERCCFLYV NSDDFQIYF TE C +FF +V IT G + E EG+ + D
Sbjct: 58 SLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDT 117
Query: 671 LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK 730
LEY+Y++D NG+RVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK
Sbjct: 118 LEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK 177
Query: 731 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEG 790
+LKH+NIVQYLGS SENG+IKIFMEQVPGGSLSALLRSKWGP+K E TI FYTKQILEG
Sbjct: 178 YLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTIKFYTKQILEG 235
Query: 791 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEI 850
LKYLH+NQIVHRDIKGDNVL+NTYSGV+KISDFGTSKRLAG+NPCTETFTGTLQYMAPEI
Sbjct: 236 LKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEI 295
Query: 851 IDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAE 910
ID+GPRGYG ADIWSLGCTIIEMAT KPPF+ELGEPQAAMFKVGMFK+HPEIPE++SAE
Sbjct: 296 IDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAE 355
Query: 911 AKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVP 970
A+AFIL CFEPDP KRA +LL + FL+ +K KK + ++ +E R + L +P
Sbjct: 356 ARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNR-----IAFKPSEGPRGVVLALP 410
Query: 971 VLVED-TSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDEN--FED 1027
E +SSSE+GSVSPD++ + D +TRA R G L +PDE+ ED
Sbjct: 411 TQGEPMATSSSEHGSVSPDSDAQPDALFERTRA----PRHHLG---HLLSVPDESSALED 463
Query: 1028 HSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHI 1087
SPE++D G F+LRKDSERRA L++IL E+Q+++ NL E +AQ +EE L HI
Sbjct: 464 RGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHI 523
Query: 1088 TTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNI 1147
+I LR+F+RS + +++ATT+SKLK++LDFDS ISQ+ +VLFGFQDAVNK+LRNH I
Sbjct: 524 KQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLI 583
Query: 1148 KPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTV 1207
+PHWMFA+D+IIR+AVQ A+TIL+PELR HF E++ D+ D+++ E P
Sbjct: 584 RPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDK---DMDEAEEGYPP---- 636
Query: 1208 RRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQ 1267
++ ++Q + L++QLG ++ ETNRLLE LV KE+E Q
Sbjct: 637 -------------------ATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQ 677
Query: 1268 ALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTI 1327
LL + +E+K QE+ HL+LK + I E P G T D EL DWLR+ GAD TI
Sbjct: 678 NLLRQTLEQKTQELYHLQLKLKSNCITENPA---GPYGQRT-DKELIDWLRLQGADAKTI 733
Query: 1328 SRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQ 1373
+ + E YTL D+L +T++DL+ LRLRGG+LC LW A+ +R Q
Sbjct: 734 EKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQ 779
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 193 bits (490), Expect = 1e-48
Identities = 116/270 (42%), Positives = 168/270 (62%), Gaps = 21/270 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKHLKHKNIV 738
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 1066 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 739 QYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 798
YLG+ + + IFME VPGGS+S+++ +++GPL E YTKQIL+G+ YLH+N
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLP--EMVFCKYTKQILQGVAYLHENC 1181
Query: 799 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLA--GIN----PCTETFTGTLQYMAPEIID 852
+VHRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I+
Sbjct: 1182 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 1240
Query: 853 KGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFK-VHPEIPESMSAEA 911
+ GYG+ +DIWS+GCT+ EMATGKPP + + AAMF +G + + P +P+ S A
Sbjct: 1241 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 1297
Query: 912 KAFILKCFEPDPDKRACANDLLVDEFLKVS 941
F+ C D +R A LL FL+ S
Sbjct: 1298 ADFVRMCLTRDQHERPSALQLLKHSFLERS 1327
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 193 bits (490), Expect = 1e-48
Identities = 116/270 (42%), Positives = 168/270 (62%), Gaps = 21/270 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKHLKHKNIV 738
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 739 QYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 798
YLG+ + + IFME VPGGS+S+++ +++GPL E YTKQIL+G+ YLH+N
Sbjct: 307 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLP--EMVFCKYTKQILQGVAYLHENC 363
Query: 799 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLA--GIN----PCTETFTGTLQYMAPEIID 852
+VHRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I+
Sbjct: 364 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 422
Query: 853 KGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFK-VHPEIPESMSAEA 911
+ GYG+ +DIWS+GCT+ EMATGKPP + + AAMF +G + + P +P+ S A
Sbjct: 423 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 479
Query: 912 KAFILKCFEPDPDKRACANDLLVDEFLKVS 941
F+ C D +R A LL FL+ S
Sbjct: 480 ADFVRMCLTRDQHERPSALQLLKHSFLERS 509
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 168 bits (426), Expect = 3e-41
Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 20/267 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKHLKHKNIV 738
+LG+G +G VY D+ +A K++ PE S L EI L K+L+H+ IV
Sbjct: 398 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 456
Query: 739 QYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 796
QY G + + IFME +PGGS+ L++ +G L E YT+QILEG+ YLH
Sbjct: 457 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 513
Query: 797 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---NPCTETFTGTLQYMAPEIIDK 853
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 514 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 570
Query: 854 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
GYG+ AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S +
Sbjct: 571 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 629
Query: 914 FILKCFEPDPDKRACANDLLVDEFLKV 940
F+ + F + +R A +LL F ++
Sbjct: 630 FLRRIF-VEARQRPSAEELLTHHFAQL 655
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 168 bits (426), Expect = 3e-41
Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 20/267 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKHLKHKNIV 738
+LG+G +G VY D+ +A K++ PE S L EI L K+L+H+ IV
Sbjct: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
Query: 739 QYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 796
QY G + + IFME +PGGS+ L++ +G L E YT+QILEG+ YLH
Sbjct: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 482
Query: 797 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---NPCTETFTGTLQYMAPEIIDK 853
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 483 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 539
Query: 854 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
GYG+ AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S +
Sbjct: 540 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 598
Query: 914 FILKCFEPDPDKRACANDLLVDEFLKV 940
F+ + F + +R A +LL F ++
Sbjct: 599 FLRRIF-VEARQRPSAEELLTHHFAQL 624
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 164 bits (415), Expect = 5e-40
Identities = 106/267 (39%), Positives = 148/267 (55%), Gaps = 14/267 (5%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 743
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
Query: 744 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 803
+ IFME G+L + R L E I Y+KQI + LH++ IVHRD
Sbjct: 1409 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1463
Query: 804 IKGDNVLINTYSGVLKISDFGTSKRL---AGINPCTETFT-GTLQYMAPEIIDKGP-RGY 858
IKG N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 1464 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1522
Query: 859 GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKC 918
G+AADIWSLGC +IEM TGK P++E M+KVGM P IPE +S E K F+ C
Sbjct: 1523 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1581
Query: 919 FEPDPDKRACANDLLVDEFLKVSSKKK 945
E DP R A+ LL F+KV + ++
Sbjct: 1582 LESDPKMRWTASQLLDHSFVKVCTDEE 1608
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 164 bits (415), Expect = 5e-40
Identities = 106/267 (39%), Positives = 148/267 (55%), Gaps = 14/267 (5%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 743
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 1299 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1358
Query: 744 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 803
+ IFME G+L + R L E I Y+KQI + LH++ IVHRD
Sbjct: 1359 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1413
Query: 804 IKGDNVLINTYSGVLKISDFGTSKRL---AGINPCTETFT-GTLQYMAPEIIDKGP-RGY 858
IKG N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 1414 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1472
Query: 859 GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKC 918
G+AADIWSLGC +IEM TGK P++E M+KVGM P IPE +S E K F+ C
Sbjct: 1473 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1531
Query: 919 FEPDPDKRACANDLLVDEFLKVSSKKK 945
E DP R A+ LL F+KV + ++
Sbjct: 1532 LESDPKMRWTASQLLDHSFVKVCTDEE 1558
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 164 bits (414), Expect = 7e-40
Identities = 95/260 (36%), Positives = 145/260 (55%), Gaps = 17/260 (6%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKHLKHKNIVQ 739
+G G + Y +D+ +A+K++ + L EEI + HL H NI++
Sbjct: 1249 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1308
Query: 740 YLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 799
LG+ E +F+E + GGS++ LL SK+G K E + YT+Q+L GL YLH+NQI
Sbjct: 1309 MLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESVVINYTEQLLRGLSYLHENQI 1365
Query: 800 VHRDIKGDNVLINTYSGVLKISDFGTSKRLA----GINPCTETFTGTLQYMAPEIIDKGP 855
+HRD+KG N+LI++ L+I+DFG + RLA G GT+ +MAPE++ +G
Sbjct: 1366 IHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQ 1424
Query: 856 RGYGKAADIWSLGCTIIEMATGKPPF--YELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
+ YG++ D+WS+GC IIEMA KPP+ + A +FK+ P IP +S +
Sbjct: 1425 Q-YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRD 1483
Query: 914 FILKCFEPDPDKRACANDLL 933
L+C E P R + +LL
Sbjct: 1484 VALRCLELQPQDRPPSRELL 1503
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 162 bits (410), Expect = 2e-39
Identities = 106/265 (40%), Positives = 156/265 (58%), Gaps = 20/265 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKHLKHKNIV 738
+LG+G +G VY D+ +A+K++ PE S+ L EI L K+L H+ IV
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
Query: 739 QYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 796
QY G + + IFME +PGGS+ L++ +G L +N YT+QILEG+ YLH
Sbjct: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTEN--VTRKYTRQILEGVHYLHS 476
Query: 797 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---NPCTETFTGTLQYMAPEIIDK 853
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I ++ TGT +M+PE+I
Sbjct: 477 NMIVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-- 533
Query: 854 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
GYG+ ADIWS+ CT++EM T KPP+ E E AA+FK+ +P++P +S +
Sbjct: 534 SGEGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD 592
Query: 914 FILKCFEPDPDKRACANDLLVDEFL 938
F+ + F + R A++LL F+
Sbjct: 593 FLKRIF-VEAKLRPSADELLRHMFV 616
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 147 bits (371), Expect = 7e-35
Identities = 88/270 (32%), Positives = 145/270 (53%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 335
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L++LH NQ++HRDIK
Sbjct: 336 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALEFLHSNQVIHRDIK 391
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 392 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 448
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 449 SLGIMAIEMIEGEPPYLN-ENPLRALYLIAT-NGTPELQNPEKLSAIFRDFLNRCLEMDV 506
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
+KR A +LL +FLK++ P ++A
Sbjct: 507 EKRGSAKELLQHQFLKIAKPLSSLTPLIAA 536
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 349 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 404
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 405 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 461
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 462 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 519
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 520 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 549
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 295 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 354
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 355 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 410
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 411 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 467
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 468 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 525
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 526 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 555
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 310 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 369
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 370 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 425
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 426 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 482
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 483 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 540
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 541 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 570
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 504
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 505 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 534
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 504
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 505 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 534
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 144 bits (363), Expect = 6e-34
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L +LH NQ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDV 504
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
D+R A +LL FLK++ P + A
Sbjct: 505 DRRGSAKELLQHPFLKLAKPLSSLTPLIIA 534
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 143 bits (361), Expect = 1e-33
Identities = 89/270 (32%), Positives = 143/270 (52%), Gaps = 11/270 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G V+ D++ +AIK+I + + + EI + K LK+ NIV +L S+
Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L++LH NQ++HRDIK
Sbjct: 315 VGDELFVVMEYLAGGSLTDVVTETC----MDEAQIAAVCRECLQALEFLHANQVIHRDIK 370
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DNVL+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 371 SDNVLLG-MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 427
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +S + F+ +C E D
Sbjct: 428 SLGIMAIEMVEGEPPYLN-ENPLRALYLIAT-NGTPELQNPEKLSPIFRDFLNRCLEMDV 485
Query: 924 DKRACANDLLVDEFLKVSSKKKKTQPKLSA 953
+KR A +LL FLK++ P + A
Sbjct: 486 EKRGSAKELLQHPFLKLAKPLSSLTPLIMA 515
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 143 bits (360), Expect = 1e-33
Identities = 95/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
LG+G+YG V+ + +AIK++P Q + +EI++ + +V+Y GS+
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDL--QEIIKEISIMQQCDSPYVVKYYGSYF 90
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+N + I ME GS+S ++R + L ++E I K L+GL+YLH + +HRDIK
Sbjct: 91 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE--IATILKSTLKGLEYLHFMRKIHRDIK 148
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
N+L+NT G K++DFG + +L T GT +MAPE+I + GY ADIW
Sbjct: 149 AGNILLNT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIW 205
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP----EIPESMSAEAKAFILKCFEP 921
SLG T IEMA GKPP+ ++ P A+F M +P PE S + F+ KC
Sbjct: 206 SLGITSIEMAEGKPPYADI-HPMRAIF---MIPTNPPPTFRKPELWSDDFTDFVKKCLVK 261
Query: 922 DPDKRACANDLLVDEFLK 939
+P++RA A LL F+K
Sbjct: 262 NPEQRATATQLLQHPFIK 279
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 140 bits (354), Expect = 6e-33
Identities = 93/258 (36%), Positives = 140/258 (54%), Gaps = 15/258 (5%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
LG+G+YG VY +AIK++P Q + +EI++ + ++V+Y GS+
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDL--QEIIKEISIMQQCDSPHVVKYYGSYF 93
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+N + I ME GS+S ++R + L ++E I + L+GL+YLH + +HRDIK
Sbjct: 94 KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDE--IATILQSTLKGLEYLHFMRKIHRDIK 151
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
N+L+NT G K++DFG + +L T GT +MAPE+I + GY ADIW
Sbjct: 152 AGNILLNT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIW 208
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP----EIPESMSAEAKAFILKCFEP 921
SLG T IEMA GKPP+ ++ P A+F M +P PE S F+ +C
Sbjct: 209 SLGITAIEMAEGKPPYADI-HPMRAIF---MIPTNPPPTFRKPELWSDNFTDFVKQCLVK 264
Query: 922 DPDKRACANDLLVDEFLK 939
P++RA A LL F++
Sbjct: 265 SPEQRATATQLLQHPFVR 282
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 139 bits (351), Expect = 1e-32
Identities = 166/666 (24%), Positives = 274/666 (41%), Gaps = 97/666 (14%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
LG G +G VY ++ V A K I + + EI + H NIV+ L +F
Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ I +E GG++ A++ PL +++ I KQ L+ L YLHDN+I+HRD+K
Sbjct: 100 YENNLWILIEFCAGGAVDAVMLELERPLTESQ--IQVVCKQTLDALNYLHDNKIIHRDLK 157
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII---DKGPRGYGKAA 862
N+L T G +K++DFG S + ++F GT +MAPE++ R Y A
Sbjct: 158 AGNILF-TLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKA 216
Query: 863 DIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI---PESMSAEAKAFILKCF 919
D+WSLG T+IEMA +PP +EL P + K+ K P P S+ K F+ KC
Sbjct: 217 DVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIA--KSEPPTLAQPSRWSSNFKDFLKKCL 273
Query: 920 EPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSI-------------- 965
E + D R + LL F+ V S K P ++ E +
Sbjct: 274 EKNVDARWTTSQLLQHPFVTVDSNK----PIRELIAEAKAEVTEEVEDGKEEDEEEETEN 329
Query: 966 SLPVPVLVEDTS----SSSEYGSVSPDTELKVDPFSFKT---------RAKSCGERDVKG 1012
SLP+P +S +SSE +S + + ++ S KT +K E+
Sbjct: 330 SLPIPASKRASSDLSIASSEEDKLSQNACI-LESVSEKTERSNSEDKLNSKILNEKPTTD 388
Query: 1013 IRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRIL-TEDQDKIVRNLME 1071
+ +E+ D E D + + E+R L + TEDQ+ + N
Sbjct: 389 EPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDIN--- 445
Query: 1072 SLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVL 1131
S+++G E + TL ++ ++S + K Q + +
Sbjct: 446 SVSEGKEN-----NIMITLETNIEHNLKSEEEK--------------------DQEKQQM 480
Query: 1132 FGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQED 1191
F NK++++ IK + +D + ++ + I + ++ DT QE
Sbjct: 481 F-----ENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGL---TKEDT--QEK 530
Query: 1192 LDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIE 1251
L +D ++ + T D + T + ++ V DS +S + G+ +E
Sbjct: 531 LGEDDKTQKDVISNT--------SDVIGTCEAADVAQKVDEDSAEDTQSND---GKEVVE 579
Query: 1252 TNRLLEELVRKEKELQALLHRAIEE--KDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTE 1309
+ L E I+E + EI+ K K Q I E + +N TE
Sbjct: 580 VGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSE-NIMDINEEPGTTE 638
Query: 1310 DSELTD 1315
E+T+
Sbjct: 639 GEEITE 644
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 139 bits (350), Expect = 2e-32
Identities = 93/260 (35%), Positives = 138/260 (53%), Gaps = 10/260 (3%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKHLKHKNIVQYLGSF 744
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS+
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 89
Query: 745 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 804
+ + I ME + GGS LLR+ GP +E I K+IL+GL YLH + +HRDI
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRA--GPF--DEFQIATMLKEILKGLDYLHSEKKIHRDI 145
Query: 805 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 864
K NVL++ G +K++DFG + +L TF GT +MAPE+I + Y ADI
Sbjct: 146 KAANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS--AYDSKADI 202
Query: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 924
WSLG T IE+A G+PP ++ P +F + P + + K FI C DP
Sbjct: 203 WSLGITAIELAKGEPPNSDM-HPMRVLFLIPK-NNPPTLVGDFTKSFKEFIDACLNKDPS 260
Query: 925 KRACANDLLVDEFLKVSSKK 944
R A +LL +F+ +SKK
Sbjct: 261 FRPTAKELLKHKFIVKNSKK 280
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 139 bits (349), Expect = 2e-32
Identities = 92/260 (35%), Positives = 140/260 (53%), Gaps = 10/260 (3%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKHLKHKNIVQYLGSF 744
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS+
Sbjct: 30 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 89
Query: 745 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 804
++ + I ME + GGS LL GPL +E I ++IL+GL YLH + +HRDI
Sbjct: 90 LKDTKLWIIMEYLGGGSALDLLEP--GPL--DETQIATILREILKGLDYLHSEKKIHRDI 145
Query: 805 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 864
K NVL++ + G +K++DFG + +L TF GT +MAPE+I + Y ADI
Sbjct: 146 KAANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDSKADI 202
Query: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 924
WSLG T IE+A G+PP EL P +F + P + + S K F+ C +P
Sbjct: 203 WSLGITAIELARGEPPHSEL-HPMKVLFLIPK-NNPPTLEGNYSKPLKEFVEACLNKEPS 260
Query: 925 KRACANDLLVDEFLKVSSKK 944
R A +LL +F+ ++KK
Sbjct: 261 FRPTAKELLKHKFILRNAKK 280
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 139 bits (349), Expect = 2e-32
Identities = 92/260 (35%), Positives = 140/260 (53%), Gaps = 10/260 (3%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKHLKHKNIVQYLGSF 744
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS+
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101
Query: 745 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 804
++ + I ME + GGS LL GPL +E I ++IL+GL YLH + +HRDI
Sbjct: 102 LKDTKLWIIMEYLGGGSALDLLEP--GPL--DETQIATILREILKGLDYLHSEKKIHRDI 157
Query: 805 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 864
K NVL++ + G +K++DFG + +L TF GT +MAPE+I + Y ADI
Sbjct: 158 KAANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDSKADI 214
Query: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 924
WSLG T IE+A G+PP EL P +F + P + + S K F+ C +P
Sbjct: 215 WSLGITAIELARGEPPHSEL-HPMKVLFLIPK-NNPPTLEGNYSKPLKEFVEACLNKEPS 272
Query: 925 KRACANDLLVDEFLKVSSKK 944
R A +LL +F+ ++KK
Sbjct: 273 FRPTAKELLKHKFILRNAKK 292
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 137 bits (346), Expect = 5e-32
Identities = 83/250 (33%), Positives = 135/250 (54%), Gaps = 11/250 (4%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S+
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 335
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ + ME + GGSL+ ++ +E I ++ L+ L++LH NQ++HRDIK
Sbjct: 336 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALEFLHSNQVIHRDIK 391
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIW 865
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 392 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 448
Query: 866 SLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PESMSAEAKAFILKCFEPDP 923
SLG IEM G+PP+ P A++ + PE+ PE +SA + F+ +C E D
Sbjct: 449 SLGIMAIEMIEGEPPYLN-ENPLRALYLIAT-NGTPELQNPEKLSAIFRDFLNRCLEMDV 506
Query: 924 DKRACANDLL 933
+KR A +LL
Sbjct: 507 EKRGSAKELL 516
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 137 bits (346), Expect = 5e-32
Identities = 89/259 (34%), Positives = 130/259 (50%), Gaps = 13/259 (5%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEI-----PERDSRYSQPLHEEIALHKHLKHKNIVQY 740
+G+G +G Y + S+ IKEI P ++ S+ +E+ L + +KH NIV +
Sbjct: 10 IGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASK---KEVILLEKMKHPNIVAF 66
Query: 741 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 800
SF ENG + I ME GG L + + G L +Q +G++ QI GLK++HD +I+
Sbjct: 67 FNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFV-QISLGLKHIHDRKIL 125
Query: 801 HRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGK 860
HRDIK N+ ++ V K+ DFG ++ L T GT Y++PEI P Y
Sbjct: 126 HRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP--YNN 183
Query: 861 AADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFE 920
DIWSLGC + E+ T K PF E Q + K+ P I S E + I + F+
Sbjct: 184 KTDIWSLGCVLYELCTLKHPF-EGNNLQQLVLKICQAHFAP-ISPGFSRELHSLISQLFQ 241
Query: 921 PDPDKRACANDLLVDEFLK 939
P R N +L FL+
Sbjct: 242 VSPRDRPSINSILKRPFLE 260
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 136 bits (343), Expect = 1e-31
Identities = 92/292 (31%), Positives = 149/292 (51%), Gaps = 23/292 (7%)
Query: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQP-----LHEEIALHKHLKHKNIVQ 739
VLGKG + Y DL+N A K IP SR ++P + +EI LH+ L HK++VQ
Sbjct: 87 VLGKGGFAKCYEMTDLTNNKVYAAKIIPH--SRVAKPHQREKIDKEIELHRILHHKHVVQ 144
Query: 740 YLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 799
+ F + I I +E S++ +L+++ E + +Y +QI+ GLKYLH+ +I
Sbjct: 145 FYHYFEDKENIYILLEYCSRRSMAHILKAR---KVLTEPEVRYYLRQIVSGLKYLHEQEI 201
Query: 800 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYG 859
+HRD+K N IN + LK+ DFG + RL + T GT Y++PE+++K +G+G
Sbjct: 202 LHRDLKLGNFFINE-AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK--QGHG 258
Query: 860 KAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCF 919
+DIW+LGC + M G+PPF + + + +P S+ A AK I
Sbjct: 259 CESDIWALGCVMYTMLLGRPPFETTNLKETYRC---IREARYTMPSSLLAPAKHLIASML 315
Query: 920 EPDPDKRACANDLLVDEFL-------KVSSKKKKTQPKLSALSAGSNEYLRS 964
+P+ R +D++ +F ++SS T P S N + ++
Sbjct: 316 SKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKA 367
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 135 bits (339), Expect = 4e-31
Identities = 93/260 (35%), Positives = 138/260 (53%), Gaps = 10/260 (3%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKHLKHKNIVQYLGSF 744
+GKG++G VY G D + +AIK I ++ + + +EI + I +Y GS+
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 745 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 804
++ + I ME + GGS LL+ GPL+ E I ++IL+GL YLH + +HRDI
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKP--GPLE--ETYIATILREILKGLDYLHSERKIHRDI 141
Query: 805 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 864
K NVL++ G +K++DFG + +L TF GT +MAPE+I + Y ADI
Sbjct: 142 KAANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDFKADI 198
Query: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 924
WSLG T IE+A G+PP +L P +F + P + S K F+ C DP
Sbjct: 199 WSLGITAIELAKGEPPNSDL-HPMRVLFLIPK-NSPPTLEGQHSKPFKEFVEACLNKDPR 256
Query: 925 KRACANDLLVDEFLKVSSKK 944
R A +LL +F+ +KK
Sbjct: 257 FRPTAKELLKHKFITRYTKK 276
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 132 bits (333), Expect = 2e-30
Identities = 89/257 (34%), Positives = 135/257 (52%), Gaps = 9/257 (3%)
Query: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745
+G GTYG VY R+++ AIK I + +EI + K KH NIV Y GS+
Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81
Query: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 805
+ I ME GGSL + GPL +E I + +++ L+GL YLH +HRDIK
Sbjct: 82 RRDKLWICMEFCGGGSLQDIYHVT-GPL--SELQIAYVSRETLQGLYYLHSKGKMHRDIK 138
Query: 806 GDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIID-KGPRGYGKAADI 864
G N+L+ T +G +K++DFG S ++ ++F GT +MAPE+ + GY + D+
Sbjct: 139 GANILL-TDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDL 197
Query: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH-PEIPESM--SAEAKAFILKCFEP 921
W++G T IE+A +PP ++L P A+F + P++ + M S F+
Sbjct: 198 WAVGITAIELAELQPPMFDL-HPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTK 256
Query: 922 DPDKRACANDLLVDEFL 938
+P KR A LL F+
Sbjct: 257 NPKKRPTAEKLLQHPFV 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,809,835
Number of Sequences: 37866
Number of extensions: 2400515
Number of successful extensions: 12213
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 613
Number of HSP's successfully gapped in prelim test: 259
Number of HSP's that attempted gapping in prelim test: 9433
Number of HSP's gapped (non-prelim): 1325
length of query: 1374
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1259
effective length of database: 13,892,928
effective search space: 17491196352
effective search space used: 17491196352
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.