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Search of human proteins with 5032291
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
(2341 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens] 4621 0.0
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 4598 0.0
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 4598 0.0
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 4598 0.0
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 4598 0.0
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 4598 0.0
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens] 4597 0.0
gi|5032293 dystrophin Dp140 isoform [Homo sapiens] 2452 0.0
gi|5032309 dystrophin Dp140b isoform [Homo sapiens] 2427 0.0
gi|5032311 dystrophin Dp140ab isoform [Homo sapiens] 2390 0.0
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens] 1908 0.0
gi|5032295 dystrophin Dp116 isoform [Homo sapiens] 1907 0.0
gi|5032307 dystrophin Dp140c isoform [Homo sapiens] 1888 0.0
gi|110611228 utrophin [Homo sapiens] 1561 0.0
gi|5032297 dystrophin Dp71 isoform [Homo sapiens] 1240 0.0
gi|5032299 dystrophin Dp71b isoform [Homo sapiens] 1214 0.0
gi|5032301 dystrophin Dp71a isoform [Homo sapiens] 1203 0.0
gi|5032303 dystrophin Dp71ab isoform [Homo sapiens] 1177 0.0
gi|148539558 dystrophin related protein 2 [Homo sapiens] 996 0.0
gi|5032305 dystrophin Dp40 isoform [Homo sapiens] 693 0.0
gi|33188443 microfilament and actin filament cross-linker protei... 249 3e-65
gi|33188445 microfilament and actin filament cross-linker protei... 249 3e-65
gi|221316624 dystonin isoform 4 [Homo sapiens] 247 1e-64
gi|221316622 dystonin isoform 3 [Homo sapiens] 247 1e-64
gi|221316618 dystonin isoform 2 [Homo sapiens] 247 1e-64
gi|34577047 dystonin isoform 1 [Homo sapiens] 247 1e-64
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 247 1e-64
gi|42717999 dystrobrevin alpha isoform 2 [Homo sapiens] 212 3e-54
gi|42718005 dystrobrevin alpha isoform 1 [Homo sapiens] 206 2e-52
gi|42717997 dystrobrevin alpha isoform 5 [Homo sapiens] 206 2e-52
>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
Length = 2341
Score = 4621 bits (11986), Expect = 0.0
Identities = 2341/2341 (100%), Positives = 2341/2341 (100%)
Query: 1 MSARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA 60
MSARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA
Sbjct: 1 MSARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA 60
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKP 120
QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKP
Sbjct: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKP 120
Query: 121 ANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIK 180
ANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIK
Sbjct: 121 ANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIK 180
Query: 181 TGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLT 240
TGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLT
Sbjct: 181 TGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLT 240
Query: 241 EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK 300
EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK
Sbjct: 241 EWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK 300
Query: 301 KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 360
KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE
Sbjct: 301 KETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 360
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF
Sbjct: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV
Sbjct: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
Query: 481 KELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR 540
KELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR
Sbjct: 481 KELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKR 540
Query: 541 QADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA 600
QADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA
Sbjct: 541 QADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA 600
Query: 601 VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 660
VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI
Sbjct: 601 VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 660
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 720
THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ
Sbjct: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 720
Query: 721 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 780
SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE
Sbjct: 721 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 780
Query: 781 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK
Sbjct: 781 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ
Sbjct: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 960
QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK
Sbjct: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 960
Query: 961 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 1020
VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD
Sbjct: 961 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 1020
Query: 1021 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 1080
VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ
Sbjct: 1021 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 1080
Query: 1081 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 1140
PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD
Sbjct: 1081 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 1140
Query: 1141 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 1200
WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ
Sbjct: 1141 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 1200
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE
Sbjct: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1320
SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE
Sbjct: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1320
Query: 1321 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL
Sbjct: 1321 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF
Sbjct: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ
Sbjct: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL
Sbjct: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG
Sbjct: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 1680
DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW
Sbjct: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 1680
Query: 1681 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWD 1740
KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWD
Sbjct: 1681 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWD 1740
Query: 1741 HPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQP 1800
HPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQP
Sbjct: 1741 HPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQP 1800
Query: 1801 MDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGII 1860
MDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGII
Sbjct: 1801 MDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGII 1860
Query: 1861 SLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVR 1920
SLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVR
Sbjct: 1861 SLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVR 1920
Query: 1921 SCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGF 1980
SCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGF
Sbjct: 1921 SCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGF 1980
Query: 1981 RYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKR 2040
RYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKR
Sbjct: 1981 RYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKR 2040
Query: 2041 YFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRL 2100
YFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRL
Sbjct: 2041 YFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRL 2100
Query: 2101 AEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERG 2160
AEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERG
Sbjct: 2101 AEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERG 2160
Query: 2161 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2220
ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL
Sbjct: 2161 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2220
Query: 2221 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSS 2280
LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSS
Sbjct: 2221 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSS 2280
Query: 2281 QPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDT 2340
QPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDT
Sbjct: 2281 QPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDT 2340
Query: 2341 M 2341
M
Sbjct: 2341 M 2341
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 1347 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1406
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 1407 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1466
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 1467 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1526
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 1527 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1586
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 1587 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1646
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 1647 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1706
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 1707 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1766
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 1767 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1826
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 1827 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1886
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 1887 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1946
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 1947 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2006
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 2007 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2066
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 2067 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2126
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 2127 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2186
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 2187 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2246
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 2247 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2306
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 2307 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2366
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 2367 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2426
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 2427 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2486
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 2487 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2546
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 2547 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2606
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 2607 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2666
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 2667 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2726
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 2727 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2786
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 2787 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2846
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 2847 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2906
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 2907 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2966
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 3026
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 3027 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 3086
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 3087 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3146
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 3147 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3206
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 3207 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3266
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 3267 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3326
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 3327 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3386
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 3387 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3446
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 3447 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3506
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 3507 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3566
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 3567 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3626
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3627 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3677
Score = 209 bits (531), Expect = 3e-53
Identities = 384/1928 (19%), Positives = 787/1928 (40%), Gaps = 267/1928 (13%)
Query: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 911 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 963
Query: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 964 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1023
Query: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 1024 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1083
Query: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 1084 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203
Query: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 1204 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1258
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ------------- 491
+LL LE + L E +F E+ G +E+ + D+L+
Sbjct: 1259 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1315
Query: 492 ----QRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDL 545
Q +TD +E+ ++ L+T ++ ++L + RR+K LE S Q Q ++ L
Sbjct: 1316 RILAQTLTDGGVMDELINEE--LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373
Query: 546 L-KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 604
+ + L I+K+LA+ D+ ++ +E QK + +L +
Sbjct: 1374 IQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------H 1412
Query: 605 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 664
+I L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 1413 EISLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESK 1467
Query: 665 QALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 724
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 1468 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1527
Query: 725 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 784
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L
Sbjct: 1528 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587
Query: 785 KTQ----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
K +P N + ++ W K Q I +++ ++++ GE + K + +++++K
Sbjct: 1588 KRSAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDK 1644
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
L LN W V + + L E + + F ++++ W+ +AD + L+ +++
Sbjct: 1645 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKK 1700
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWI 959
+ ++K + +K L EL I +++ T + A + +E ++ + N ++
Sbjct: 1701 KPQQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1757
Query: 960 KVSRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ 1015
+S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 1758 AISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNE 1813
Query: 1016 EGPFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW-- 1066
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1814 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873
Query: 1067 ----------------------------KAVNRLLQELRAKQPDL------APGLTTIGA 1092
+ + + +EL+ K+ +L A GL+ GA
Sbjct: 1874 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1933
Query: 1093 S----PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLM 1122
+ PTQ TV T V+T++ + +PS+ +
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993
Query: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 1182
E+ T ++ L ++Q++ + + D ED+ + K L+Q +
Sbjct: 1994 TEI----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2043
Query: 1183 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM-------- 1234
+ ++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 2044 I-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 2102
Query: 1235 --LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTN 1292
+K QWL EAEQ L + + E+W+ Y K+L + Q QT
Sbjct: 2103 YDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTV 2150
Query: 1293 VDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPL 1352
V N ++++ S D + ++N W+ + K++S+R+ LEE +L +F
Sbjct: 2151 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2210
Query: 1353 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1412
DL +F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+
Sbjct: 2211 DLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLN 2263
Query: 1413 ENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 1471
E +L S S ++ L+ +L N +W ++ + + +EA +L L+
Sbjct: 2264 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2323
Query: 1472 E-------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKT 1513
+ LL+WL E+ Q G F AVQ KQ DV + L
Sbjct: 2324 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK 2383
Query: 1514 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQ 1563
++P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 2384 EKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQP 2440
Query: 1564 AEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLL 1623
T KL + S+ ++ + + E TD L L +VIK VGDL
Sbjct: 2441 VVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL- 2495
Query: 1624 IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWK 1681
+ + + + K KA ++ + + + A+ L + T +E + +W
Sbjct: 2496 -EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2554
Query: 1682 LLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDH 1741
+Q +++R +QL+E +D S +L + + K+ + T
Sbjct: 2555 EVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQ 2609
Query: 1742 PKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM 1801
K+TE Q DL + + + L L LL +A D H + +N
Sbjct: 2610 KKITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-A 2660
Query: 1802 DILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFK 1856
I ++ LE+ H L PL ++ L WL T T + R+L
Sbjct: 2661 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2720
Query: 1857 TGIISLCK 1864
G+ L K
Sbjct: 2721 KGVKELMK 2728
Score = 186 bits (473), Expect = 2e-46
Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)
Query: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 751 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 810
Query: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 811 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870
Query: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 871 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 928
Query: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 929 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 988
Query: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 989 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1048
Query: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 1049 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1106
Query: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 1107 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1165
Query: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 1166 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1225
Query: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1285
Query: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345
Query: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1405
Query: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
+ DL E SL+ +K Q K+ A Q
Sbjct: 1406 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1432
Query: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 1433 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1487
Query: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 1488 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1547
Query: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 1548 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1607
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 1608 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1657
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1029
E + L + +K +E ++ ++H+ W+ L+ + + DV + + +
Sbjct: 1658 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1717
Query: 1030 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1085
+P V+ + +L + + V+ ++ +L+ + A++ ++ +A P +L
Sbjct: 1718 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1777
Query: 1086 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ I + Q V KE +K + L + +TD
Sbjct: 1778 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1837
Query: 1146 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1201
+ IK Q + L+D+ K+ + Q + Q ++L+ +++ K S E
Sbjct: 1838 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1897
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1243
R +I+ I + + +E L R+Q + +D S +W E
Sbjct: 1898 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1955
Query: 1244 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1282
+EE V+ + S+ Y + + + + E +QL
Sbjct: 1956 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2015
Query: 1283 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
AKD L+Q +D+ + L+ + + K+ ++
Sbjct: 2016 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2075
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1384
W ++K +R+ + + ++F D++ F WLTEAE RK ++ E+
Sbjct: 2076 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2128
Query: 1385 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1442
+ K +W ++LQ I V L+ ++I++ DA +LQ +L ++N +W
Sbjct: 2129 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2184
Query: 1443 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1502
E+ K+ + + LE + L E ++WL+ D+ S G + +K
Sbjct: 2185 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2244
Query: 1503 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1562
V + EL ++ ++ ET L P+ PEE+ + L
Sbjct: 2245 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2285
Query: 1563 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1622
+ ++ N +W K++ + Q +I+ ++ L +L++ ++L+ +L + + ++
Sbjct: 2286 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2345
Query: 1623 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1682
Q+ V+ + + +V + + L P LEDL++ WK
Sbjct: 2346 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2403
Query: 1683 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1733
AV +++L D P AS T V P E AIS ++P + E
Sbjct: 2404 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2460
Query: 1734 TQTTCWDHPKMTELYQSLADLNNV 1757
+ TEL L+ L+ V
Sbjct: 2461 VPALADFNRAWTELTDWLSLLDQV 2484
Score = 156 bits (395), Expect = 2e-37
Identities = 332/1861 (17%), Positives = 729/1861 (39%), Gaps = 289/1861 (15%)
Query: 15 VRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 74
+R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS L
Sbjct: 934 MRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QSGLY 989
Query: 75 SHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRL 127
+++EM K ++ Q +I+ KKL ++ K + +
Sbjct: 990 YLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1049
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
Q K + EV + L + E+++ QL C L + ++ + V + G++I
Sbjct: 1050 QTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKN 1109
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
+ + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+ +
Sbjct: 1110 EAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE 1169
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGEALK 295
E +R P L V K ++E ++++ +K +TE EALK
Sbjct: 1170 EEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALK 1229
Query: 296 TVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMETFDQ 342
L T + K L W ++ +A +WLN + K E
Sbjct: 1230 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1289
Query: 343 NVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANLMAN 400
+ I++ + + L+ SE P Q + + L ++++ + T + +
Sbjct: 1290 GAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHE 1348
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAEIQQ 459
+KL+E I ++ H I+ I K+L + +D + P EA+ Q
Sbjct: 1349 EAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQKIQ 1406
Query: 460 GVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRITDE 497
E ++M + N+G L Q+ N +QR+ +
Sbjct: 1407 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1466
Query: 498 RK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDIEKK 555
+ +E+K+ L+TK + ++SQ + + + K + + ++K ++KK
Sbjct: 1467 KMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKK 1525
Query: 556 LASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 602
P+ DER K+ E ++L+K + +R++ L+E AA +E
Sbjct: 1526 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Query: 603 ----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE--------- 643
P+ + W + K + ++++ I V E V+ +
Sbjct: 1586 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL 1645
Query: 644 ------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
++ LE T+ + H+++ +++ + LL+ +
Sbjct: 1646 SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-- 1703
Query: 686 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 745
++E+ LK +K L ++D + + + R ++ +S+L+ ++ ++
Sbjct: 1704 ---QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS 1760
Query: 746 KMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL 804
++ + G+ +++ +F+ DI K+ E +Q + + K + + K++
Sbjct: 1761 --HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFNKDM 1808
Query: 805 -QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
+D G + +++ + + I + + + I Q+ L + + +++ S R+K+
Sbjct: 1809 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRKKAL 1865
Query: 864 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 922
E + +++R ++ + L++ + +AS+P EP E+++KE +++ EEL +
Sbjct: 1866 EISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAVRRQ 1924
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ- 981
+ L+E G + V E Q + +W ++ + + AQI + +
Sbjct: 1925 AEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1972
Query: 982 -LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
+ ED+ +++++ P EI + + +V++ A D E++
Sbjct: 1973 TMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFEDLFK 2025
Query: 1041 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1100
+ + L K + Q +++ + S+ A + A+P + V L
Sbjct: 2026 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVERVKL 2066
Query: 1101 VTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLLDQV 1148
+ A+S+L+ + ++ F+R+ W WL+ +Q
Sbjct: 2067 --------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2118
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
++ ++ + +K+ +QD + QR+ + L + + ++S +A +I+
Sbjct: 2119 LRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQ 2174
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+++ + +W EV + L +R+++ L+E +D +++ EEA+ + A LE
Sbjct: 2175 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLE 2231
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKVHMI 1318
KE +++K+ + K L ++L Q + N+ +L S ++ K+
Sbjct: 2232 PGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2286
Query: 1319 TENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL---------- 1361
+ N W + + + E++ +E + + L+ L L WL
Sbjct: 2287 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2346
Query: 1362 -------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1405
TE A +V + ++ + L ++ + + ++ +DL E +A
Sbjct: 2347 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2406
Query: 1406 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
+ L + L + L E L + S L
Sbjct: 2407 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 2466
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETV 1525
+ + EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 2467 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP--------- 2517
Query: 1526 RIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKI 1585
LE+L + L + Q ++ + E + +W+++ H + ++++
Sbjct: 2518 ----------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2567
Query: 1586 DETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK 1645
+E L+ + EA +E + L QA SW+ G +D++Q + + K L ++ +
Sbjct: 2568 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQ 2626
Query: 1646 ENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLHEAH 1698
NV NDLA +L L Y+ E++N W+ + V +R L E H
Sbjct: 2627 TNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETH 2680
Query: 1699 R 1699
R
Sbjct: 2681 R 2681
Score = 107 bits (266), Expect = 2e-22
Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)
Query: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 408 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 464
Query: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 465 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 524
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 525 LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 582
Query: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 583 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 625
Query: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 626 KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 671
Query: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
+ QI + E+ Q +R QI TV E + D
Sbjct: 672 TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 719
Query: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 720 --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 757
Query: 706 GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 752
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 758 --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 815
Query: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
W + +I F L + EQ T ENW E K LK
Sbjct: 816 N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 864
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
+D + + + + + I K + L + +++V + R+K L
Sbjct: 865 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 924
Query: 863 EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 925 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 984
Query: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 985 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1042
Query: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 1043 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1098
Query: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 1099 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1149
Query: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
+TV+L + +E+ +W++ ++ +
Sbjct: 1150 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1177
Query: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
+++ + + + K ++ +Q+ +++ L+T + N + A+ + +E +
Sbjct: 1178 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1236
Query: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296
Query: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1297 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1351
Query: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1352 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1402
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1403 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1461
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1462 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1511
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1512 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1571
Query: 1567 VN--TEW 1571
+N TEW
Sbjct: 1572 MNVLTEW 1578
Score = 99.8 bits (247), Expect = 3e-20
Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)
Query: 775 WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 829
WL AE L+ + +I + E K +++ E + D + Q V + G ++I
Sbjct: 346 WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 404
Query: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 885
S+ + + +QE++ LN RW+ C +++ +K+ + ++ + L E WL E
Sbjct: 405 SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 462
Query: 886 ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 945
+ PL P E LK +++Q K+L E+L Q + L T V+V
Sbjct: 463 TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 519
Query: 946 KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1005
LE +LK +W + R ++ ++ + K + L E+ WLS
Sbjct: 520 ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 569
Query: 1006 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1052
+ + N+ + G D E ++Q K+ + ++ S Q L K K T
Sbjct: 570 KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 629
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
Q + L++ + W + L+Q+L ++ +TT S TQT + T VT I
Sbjct: 630 QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 686
Query: 1113 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1157
++ E+P + ++ + TEL W++ + V++S + G
Sbjct: 687 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 746
Query: 1158 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1216
+ D+ E K A ++ ++ +L++ +AQ L + N+ I E++ ++
Sbjct: 747 NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803
Query: 1217 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1276
W E + L R L E + + ++ EQ+ A L+ P AI+ ++
Sbjct: 804 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 862
Query: 1277 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1336
K L Q ++ ++ L + ++ + V R
Sbjct: 863 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 920
Query: 1337 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
E L+ L ++ + W+ ++ET ++ Q + ++E G +
Sbjct: 921 EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 974
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q LQ ++ + L +++ + S+ + Q + + +W +L + +
Sbjct: 975 QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
LE ++ +++ +Q L W+ D L + P GD ++KQ R +++T
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1093
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
+P + S EG +K+ E PE ++ L + +E+NT+W+ +
Sbjct: 1094 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1133
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1632
+ + LE+ LQ+ E+ + QA E ++ ++ D LQ +E
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1190
Query: 1633 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1691
++K + E + V + + + ++ L LE L T ++ L + +
Sbjct: 1191 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1250
Query: 1692 RQLHE 1696
+ L E
Sbjct: 1251 KTLEE 1255
Score = 65.9 bits (159), Expect = 5e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 294 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 353
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 354 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 413
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 414 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 466
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 467 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 525
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 526 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 583
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 584 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 640
Query: 1440 FKWSELRKK 1448
W L +K
Sbjct: 641 RCWDNLVQK 649
Score = 47.4 bits (111), Expect = 2e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 255 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 314
Query: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 315 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 374
Query: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 375 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 416
Query: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 417 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 471
Query: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 472 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 527
Query: 1676 LNTRWKLLQVAVEDR 1690
L RW + EDR
Sbjct: 528 LGDRWANICRWTEDR 542
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 1232 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1291
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 1292 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1351
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1411
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 1412 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1471
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 1472 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1531
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 1532 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1591
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 1592 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1651
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 1652 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1711
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 1712 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1771
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 1772 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1831
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 1832 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 1891
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 1892 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 1951
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 1952 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2011
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 2012 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2071
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 2072 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2131
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 2132 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2191
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 2192 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2251
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 2252 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2311
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 2312 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2371
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 2372 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2431
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 2432 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2491
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 2492 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2551
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 2552 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2611
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 2612 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2671
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 2672 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2731
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 2732 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2791
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 2792 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2851
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 2911
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 2912 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 2971
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 2972 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3031
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 3032 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3091
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 3092 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3151
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 3152 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3211
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 3212 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3271
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 3272 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3331
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 3332 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3391
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 3392 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3451
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 3452 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3511
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3512 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3562
Score = 209 bits (531), Expect = 3e-53
Identities = 384/1928 (19%), Positives = 787/1928 (40%), Gaps = 267/1928 (13%)
Query: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 796 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 848
Query: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 849 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908
Query: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 909 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968
Query: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 969 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088
Query: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1143
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ------------- 491
+LL LE + L E +F E+ G +E+ + D+L+
Sbjct: 1144 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200
Query: 492 ----QRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDL 545
Q +TD +E+ ++ L+T ++ ++L + RR+K LE S Q Q ++ L
Sbjct: 1201 RILAQTLTDGGVMDELINEE--LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 546 L-KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 604
+ + L I+K+LA+ D+ ++ +E QK + +L +
Sbjct: 1259 IQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------H 1297
Query: 605 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 664
+I L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 1298 EISLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESK 1352
Query: 665 QALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 724
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 1353 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1412
Query: 725 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 784
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L
Sbjct: 1413 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1472
Query: 785 KTQ----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
K +P N + ++ W K Q I +++ ++++ GE + K + +++++K
Sbjct: 1473 KRSAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDK 1529
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
L LN W V + + L E + + F ++++ W+ +AD + L+ +++
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKK 1585
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWI 959
+ ++K + +K L EL I +++ T + A + +E ++ + N ++
Sbjct: 1586 KPQQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1642
Query: 960 KVSRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ 1015
+S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 1643 AISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNE 1698
Query: 1016 EGPFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW-- 1066
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1699 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1758
Query: 1067 ----------------------------KAVNRLLQELRAKQPDL------APGLTTIGA 1092
+ + + +EL+ K+ +L A GL+ GA
Sbjct: 1759 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1818
Query: 1093 S----PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLM 1122
+ PTQ TV T V+T++ + +PS+ +
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878
Query: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 1182
E+ T ++ L ++Q++ + + D ED+ + K L+Q +
Sbjct: 1879 TEI----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 1928
Query: 1183 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM-------- 1234
+ ++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 1929 I-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 1987
Query: 1235 --LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTN 1292
+K QWL EAEQ L + + E+W+ Y K+L + Q QT
Sbjct: 1988 YDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTV 2035
Query: 1293 VDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPL 1352
V N ++++ S D + ++N W+ + K++S+R+ LEE +L +F
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095
Query: 1353 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1412
DL +F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+
Sbjct: 2096 DLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLN 2148
Query: 1413 ENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 1471
E +L S S ++ L+ +L N +W ++ + + +EA +L L+
Sbjct: 2149 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 1472 E-------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKT 1513
+ LL+WL E+ Q G F AVQ KQ DV + L
Sbjct: 2209 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK 2268
Query: 1514 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQ 1563
++P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 2269 EKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQP 2325
Query: 1564 AEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLL 1623
T KL + S+ ++ + + E TD L L +VIK VGDL
Sbjct: 2326 VVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL- 2380
Query: 1624 IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWK 1681
+ + + + K KA ++ + + + A+ L + T +E + +W
Sbjct: 2381 -EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2439
Query: 1682 LLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDH 1741
+Q +++R +QL+E +D S +L + + K+ + T
Sbjct: 2440 EVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQ 2494
Query: 1742 PKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM 1801
K+TE Q DL + + + L L LL +A D H + +N
Sbjct: 2495 KKITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-A 2545
Query: 1802 DILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFK 1856
I ++ LE+ H L PL ++ L WL T T + R+L
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605
Query: 1857 TGIISLCK 1864
G+ L K
Sbjct: 2606 KGVKELMK 2613
Score = 186 bits (473), Expect = 2e-46
Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)
Query: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 636 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 695
Query: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 696 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 755
Query: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 756 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 813
Query: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 814 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 873
Query: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 874 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933
Query: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 934 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 991
Query: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 992 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1050
Query: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 1051 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1110
Query: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 1111 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1170
Query: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 1171 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230
Query: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1290
Query: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
+ DL E SL+ +K Q K+ A Q
Sbjct: 1291 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1317
Query: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 1318 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372
Query: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432
Query: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1492
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 1493 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1542
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1029
E + L + +K +E ++ ++H+ W+ L+ + + DV + + +
Sbjct: 1543 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1602
Query: 1030 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1085
+P V+ + +L + + V+ ++ +L+ + A++ ++ +A P +L
Sbjct: 1603 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1662
Query: 1086 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ I + Q V KE +K + L + +TD
Sbjct: 1663 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1722
Query: 1146 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1201
+ IK Q + L+D+ K+ + Q + Q ++L+ +++ K S E
Sbjct: 1723 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1782
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1243
R +I+ I + + +E L R+Q + +D S +W E
Sbjct: 1783 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1840
Query: 1244 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1282
+EE V+ + S+ Y + + + + E +QL
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900
Query: 1283 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
AKD L+Q +D+ + L+ + + K+ ++
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 1960
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1384
W ++K +R+ + + ++F D++ F WLTEAE RK ++ E+
Sbjct: 1961 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2013
Query: 1385 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1442
+ K +W ++LQ I V L+ ++I++ DA +LQ +L ++N +W
Sbjct: 2014 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2069
Query: 1443 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1502
E+ K+ + + LE + L E ++WL+ D+ S G + +K
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129
Query: 1503 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1562
V + EL ++ ++ ET L P+ PEE+ + L
Sbjct: 2130 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2170
Query: 1563 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1622
+ ++ N +W K++ + Q +I+ ++ L +L++ ++L+ +L + + ++
Sbjct: 2171 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2230
Query: 1623 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1682
Q+ V+ + + +V + + L P LEDL++ WK
Sbjct: 2231 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2288
Query: 1683 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1733
AV +++L D P AS T V P E AIS ++P + E
Sbjct: 2289 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2345
Query: 1734 TQTTCWDHPKMTELYQSLADLNNV 1757
+ TEL L+ L+ V
Sbjct: 2346 VPALADFNRAWTELTDWLSLLDQV 2369
Score = 156 bits (395), Expect = 2e-37
Identities = 332/1861 (17%), Positives = 729/1861 (39%), Gaps = 289/1861 (15%)
Query: 15 VRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 74
+R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS L
Sbjct: 819 MRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QSGLY 874
Query: 75 SHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRL 127
+++EM K ++ Q +I+ KKL ++ K + +
Sbjct: 875 YLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 934
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
Q K + EV + L + E+++ QL C L + ++ + V + G++I
Sbjct: 935 QTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKN 994
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
+ + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+ +
Sbjct: 995 EAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE 1054
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGEALK 295
E +R P L V K ++E ++++ +K +TE EALK
Sbjct: 1055 EEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALK 1114
Query: 296 TVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMETFDQ 342
L T + K L W ++ +A +WLN + K E
Sbjct: 1115 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 343 NVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANLMAN 400
+ I++ + + L+ SE P Q + + L ++++ + T + +
Sbjct: 1175 GAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHE 1233
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAEIQQ 459
+KL+E I ++ H I+ I K+L + +D + P EA+ Q
Sbjct: 1234 EAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQKIQ 1291
Query: 460 GVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRITDE 497
E ++M + N+G L Q+ N +QR+ +
Sbjct: 1292 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1351
Query: 498 RK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDIEKK 555
+ +E+K+ L+TK + ++SQ + + + K + + ++K ++KK
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKK 1410
Query: 556 LASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 602
P+ DER K+ E ++L+K + +R++ L+E AA +E
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 603 ----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE--------- 643
P+ + W + K + ++++ I V E V+ +
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL 1530
Query: 644 ------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
++ LE T+ + H+++ +++ + LL+ +
Sbjct: 1531 SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-- 1588
Query: 686 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 745
++E+ LK +K L ++D + + + R ++ +S+L+ ++ ++
Sbjct: 1589 ---QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS 1645
Query: 746 KMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL 804
++ + G+ +++ +F+ DI K+ E +Q + + K + + K++
Sbjct: 1646 --HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFNKDM 1693
Query: 805 -QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
+D G + +++ + + I + + + I Q+ L + + +++ S R+K+
Sbjct: 1694 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRKKAL 1750
Query: 864 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 922
E + +++R ++ + L++ + +AS+P EP E+++KE +++ EEL +
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAVRRQ 1809
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ- 981
+ L+E G + V E Q + +W ++ + + AQI + +
Sbjct: 1810 AEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 982 -LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
+ ED+ +++++ P EI + + +V++ A D E++
Sbjct: 1858 TMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFEDLFK 1910
Query: 1041 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1100
+ + L K + Q +++ + S+ A + A+P + V L
Sbjct: 1911 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVERVKL 1951
Query: 1101 VTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLLDQV 1148
+ A+S+L+ + ++ F+R+ W WL+ +Q
Sbjct: 1952 --------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
++ ++ + +K+ +QD + QR+ + L + + ++S +A +I+
Sbjct: 2004 LRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQ 2059
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+++ + +W EV + L +R+++ L+E +D +++ EEA+ + A LE
Sbjct: 2060 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLE 2116
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKVHMI 1318
KE +++K+ + K L ++L Q + N+ +L S ++ K+
Sbjct: 2117 PGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2171
Query: 1319 TENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL---------- 1361
+ N W + + + E++ +E + + L+ L L WL
Sbjct: 2172 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2231
Query: 1362 -------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1405
TE A +V + ++ + L ++ + + ++ +DL E +A
Sbjct: 2232 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2291
Query: 1406 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
+ L + L + L E L + S L
Sbjct: 2292 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 2351
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETV 1525
+ + EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 2352 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP--------- 2402
Query: 1526 RIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKI 1585
LE+L + L + Q ++ + E + +W+++ H + ++++
Sbjct: 2403 ----------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2452
Query: 1586 DETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK 1645
+E L+ + EA +E + L QA SW+ G +D++Q + + K L ++ +
Sbjct: 2453 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQ 2511
Query: 1646 ENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLHEAH 1698
NV NDLA +L L Y+ E++N W+ + V +R L E H
Sbjct: 2512 TNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETH 2565
Query: 1699 R 1699
R
Sbjct: 2566 R 2566
Score = 107 bits (266), Expect = 2e-22
Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)
Query: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 293 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 349
Query: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 350 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 409
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 410 LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467
Query: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 468 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 510
Query: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 511 KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 556
Query: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
+ QI + E+ Q +R QI TV E + D
Sbjct: 557 TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 604
Query: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 605 --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 642
Query: 706 GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 752
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 643 --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 700
Query: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
W + +I F L + EQ T ENW E K LK
Sbjct: 701 N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 749
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
+D + + + + + I K + L + +++V + R+K L
Sbjct: 750 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 809
Query: 863 EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 810 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 869
Query: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 870 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 927
Query: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 928 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 983
Query: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 984 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1034
Query: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
+TV+L + +E+ +W++ ++ +
Sbjct: 1035 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1062
Query: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
+++ + + + K ++ +Q+ +++ L+T + N + A+ + +E +
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1121
Query: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181
Query: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1182 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1236
Query: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1237 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1287
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1288 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1346
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1347 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1396
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1397 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1456
Query: 1567 VN--TEW 1571
+N TEW
Sbjct: 1457 MNVLTEW 1463
Score = 99.8 bits (247), Expect = 3e-20
Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)
Query: 775 WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 829
WL AE L+ + +I + E K +++ E + D + Q V + G ++I
Sbjct: 231 WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 289
Query: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 885
S+ + + +QE++ LN RW+ C +++ +K+ + ++ + L E WL E
Sbjct: 290 SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 347
Query: 886 ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 945
+ PL P E LK +++Q K+L E+L Q + L T V+V
Sbjct: 348 TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 404
Query: 946 KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1005
LE +LK +W + R ++ ++ + K + L E+ WLS
Sbjct: 405 ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 454
Query: 1006 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1052
+ + N+ + G D E ++Q K+ + ++ S Q L K K T
Sbjct: 455 KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 514
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
Q + L++ + W + L+Q+L ++ +TT S TQT + T VT I
Sbjct: 515 QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 571
Query: 1113 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1157
++ E+P + ++ + TEL W++ + V++S + G
Sbjct: 572 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 631
Query: 1158 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1216
+ D+ E K A ++ ++ +L++ +AQ L + N+ I E++ ++
Sbjct: 632 NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688
Query: 1217 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1276
W E + L R L E + + ++ EQ+ A L+ P AI+ ++
Sbjct: 689 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747
Query: 1277 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1336
K L Q ++ ++ L + ++ + V R
Sbjct: 748 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 805
Query: 1337 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
E L+ L ++ + W+ ++ET ++ Q + ++E G +
Sbjct: 806 EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 859
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q LQ ++ + L +++ + S+ + Q + + +W +L + +
Sbjct: 860 QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
LE ++ +++ +Q L W+ D L + P GD ++KQ R +++T
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
+P + S EG +K+ E PE ++ L + +E+NT+W+ +
Sbjct: 979 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1018
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1632
+ + LE+ LQ+ E+ + QA E ++ ++ D LQ +E
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1075
Query: 1633 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1691
++K + E + V + + + ++ L LE L T ++ L + +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 1692 RQLHE 1696
+ L E
Sbjct: 1136 KTLEE 1140
Score = 65.9 bits (159), Expect = 5e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 179 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 238
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 239 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 298
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 299 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 351
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 352 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 410
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 411 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 468
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 469 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525
Query: 1440 FKWSELRKK 1448
W L +K
Sbjct: 526 RCWDNLVQK 534
Score = 47.4 bits (111), Expect = 2e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 140 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 199
Query: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 200 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 260 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 301
Query: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 302 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 356
Query: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 357 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 412
Query: 1676 LNTRWKLLQVAVEDR 1690
L RW + EDR
Sbjct: 413 LGDRWANICRWTEDR 427
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 1351 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1410
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 1411 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1590
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 1591 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1650
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1710
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 1711 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1770
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 1771 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1830
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1950
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 1951 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2010
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 2011 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 2071 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2130
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 2131 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2190
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 2191 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2250
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 2251 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2310
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 2311 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2370
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 2371 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2430
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 2431 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2490
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 2491 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2550
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 2551 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2610
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 2611 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2670
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 2671 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2730
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 2731 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2790
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 2791 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 3030
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 3031 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 3090
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 3091 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3150
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 3151 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3210
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 3211 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3270
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 3271 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3330
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 3331 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3390
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 3391 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3450
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 3451 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3510
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 3511 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3570
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 3571 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3630
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3631 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681
Score = 209 bits (531), Expect = 3e-53
Identities = 384/1928 (19%), Positives = 787/1928 (40%), Gaps = 267/1928 (13%)
Query: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 915 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 967
Query: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 968 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027
Query: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087
Query: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
Query: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1262
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ------------- 491
+LL LE + L E +F E+ G +E+ + D+L+
Sbjct: 1263 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1319
Query: 492 ----QRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDL 545
Q +TD +E+ ++ L+T ++ ++L + RR+K LE S Q Q ++ L
Sbjct: 1320 RILAQTLTDGGVMDELINEE--LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377
Query: 546 L-KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 604
+ + L I+K+LA+ D+ ++ +E QK + +L +
Sbjct: 1378 IQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------H 1416
Query: 605 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 664
+I L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 1417 EISLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESK 1471
Query: 665 QALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 724
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 1472 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1531
Query: 725 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 784
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L
Sbjct: 1532 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591
Query: 785 KTQ----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
K +P N + ++ W K Q I +++ ++++ GE + K + +++++K
Sbjct: 1592 KRSAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDK 1648
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
L LN W V + + L E + + F ++++ W+ +AD + L+ +++
Sbjct: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKK 1704
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWI 959
+ ++K + +K L EL I +++ T + A + +E ++ + N ++
Sbjct: 1705 KPQQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1761
Query: 960 KVSRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ 1015
+S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 1762 AISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNE 1817
Query: 1016 EGPFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW-- 1066
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
Query: 1067 ----------------------------KAVNRLLQELRAKQPDL------APGLTTIGA 1092
+ + + +EL+ K+ +L A GL+ GA
Sbjct: 1878 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1937
Query: 1093 S----PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLM 1122
+ PTQ TV T V+T++ + +PS+ +
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
Query: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 1182
E+ T ++ L ++Q++ + + D ED+ + K L+Q +
Sbjct: 1998 TEI----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2047
Query: 1183 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM-------- 1234
+ ++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 2048 I-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 2106
Query: 1235 --LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTN 1292
+K QWL EAEQ L + + E+W+ Y K+L + Q QT
Sbjct: 2107 YDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTV 2154
Query: 1293 VDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPL 1352
V N ++++ S D + ++N W+ + K++S+R+ LEE +L +F
Sbjct: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
Query: 1353 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1412
DL +F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+
Sbjct: 2215 DLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLN 2267
Query: 1413 ENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 1471
E +L S S ++ L+ +L N +W ++ + + +EA +L L+
Sbjct: 2268 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2327
Query: 1472 E-------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKT 1513
+ LL+WL E+ Q G F AVQ KQ DV + L
Sbjct: 2328 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK 2387
Query: 1514 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQ 1563
++P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 2388 EKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQP 2444
Query: 1564 AEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLL 1623
T KL + S+ ++ + + E TD L L +VIK VGDL
Sbjct: 2445 VVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL- 2499
Query: 1624 IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWK 1681
+ + + + K KA ++ + + + A+ L + T +E + +W
Sbjct: 2500 -EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2558
Query: 1682 LLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDH 1741
+Q +++R +QL+E +D S +L + + K+ + T
Sbjct: 2559 EVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQ 2613
Query: 1742 PKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM 1801
K+TE Q DL + + + L L LL +A D H + +N
Sbjct: 2614 KKITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-A 2664
Query: 1802 DILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFK 1856
I ++ LE+ H L PL ++ L WL T T + R+L
Sbjct: 2665 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2724
Query: 1857 TGIISLCK 1864
G+ L K
Sbjct: 2725 KGVKELMK 2732
Score = 186 bits (473), Expect = 2e-46
Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)
Query: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 755 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 814
Query: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 815 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874
Query: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 875 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932
Query: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 933 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992
Query: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 993 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052
Query: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 1053 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1110
Query: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1169
Query: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 1170 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Query: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1289
Query: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
Query: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1409
Query: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
+ DL E SL+ +K Q K+ A Q
Sbjct: 1410 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1436
Query: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 1437 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1491
Query: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 1492 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1551
Query: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 1552 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1611
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 1612 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1661
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1029
E + L + +K +E ++ ++H+ W+ L+ + + DV + + +
Sbjct: 1662 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1721
Query: 1030 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1085
+P V+ + +L + + V+ ++ +L+ + A++ ++ +A P +L
Sbjct: 1722 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1781
Query: 1086 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ I + Q V KE +K + L + +TD
Sbjct: 1782 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1841
Query: 1146 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1201
+ IK Q + L+D+ K+ + Q + Q ++L+ +++ K S E
Sbjct: 1842 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1901
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1243
R +I+ I + + +E L R+Q + +D S +W E
Sbjct: 1902 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1959
Query: 1244 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1282
+EE V+ + S+ Y + + + + E +QL
Sbjct: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2019
Query: 1283 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
AKD L+Q +D+ + L+ + + K+ ++
Sbjct: 2020 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2079
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1384
W ++K +R+ + + ++F D++ F WLTEAE RK ++ E+
Sbjct: 2080 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2132
Query: 1385 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1442
+ K +W ++LQ I V L+ ++I++ DA +LQ +L ++N +W
Sbjct: 2133 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2188
Query: 1443 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1502
E+ K+ + + LE + L E ++WL+ D+ S G + +K
Sbjct: 2189 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2248
Query: 1503 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1562
V + EL ++ ++ ET L P+ PEE+ + L
Sbjct: 2249 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2289
Query: 1563 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1622
+ ++ N +W K++ + Q +I+ ++ L +L++ ++L+ +L + + ++
Sbjct: 2290 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2349
Query: 1623 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1682
Q+ V+ + + +V + + L P LEDL++ WK
Sbjct: 2350 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2407
Query: 1683 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1733
AV +++L D P AS T V P E AIS ++P + E
Sbjct: 2408 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2464
Query: 1734 TQTTCWDHPKMTELYQSLADLNNV 1757
+ TEL L+ L+ V
Sbjct: 2465 VPALADFNRAWTELTDWLSLLDQV 2488
Score = 156 bits (395), Expect = 2e-37
Identities = 332/1861 (17%), Positives = 729/1861 (39%), Gaps = 289/1861 (15%)
Query: 15 VRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 74
+R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS L
Sbjct: 938 MRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QSGLY 993
Query: 75 SHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRL 127
+++EM K ++ Q +I+ KKL ++ K + +
Sbjct: 994 YLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1053
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
Q K + EV + L + E+++ QL C L + ++ + V + G++I
Sbjct: 1054 QTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKN 1113
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
+ + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+ +
Sbjct: 1114 EAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE 1173
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGEALK 295
E +R P L V K ++E ++++ +K +TE EALK
Sbjct: 1174 EEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALK 1233
Query: 296 TVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMETFDQ 342
L T + K L W ++ +A +WLN + K E
Sbjct: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1293
Query: 343 NVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANLMAN 400
+ I++ + + L+ SE P Q + + L ++++ + T + +
Sbjct: 1294 GAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHE 1352
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAEIQQ 459
+KL+E I ++ H I+ I K+L + +D + P EA+ Q
Sbjct: 1353 EAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQKIQ 1410
Query: 460 GVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRITDE 497
E ++M + N+G L Q+ N +QR+ +
Sbjct: 1411 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
Query: 498 RK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDIEKK 555
+ +E+K+ L+TK + ++SQ + + + K + + ++K ++KK
Sbjct: 1471 KMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKK 1529
Query: 556 LASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 602
P+ DER K+ E ++L+K + +R++ L+E AA +E
Sbjct: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Query: 603 ----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE--------- 643
P+ + W + K + ++++ I V E V+ +
Sbjct: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL 1649
Query: 644 ------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
++ LE T+ + H+++ +++ + LL+ +
Sbjct: 1650 SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-- 1707
Query: 686 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 745
++E+ LK +K L ++D + + + R ++ +S+L+ ++ ++
Sbjct: 1708 ---QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS 1764
Query: 746 KMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL 804
++ + G+ +++ +F+ DI K+ E +Q + + K + + K++
Sbjct: 1765 --HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFNKDM 1812
Query: 805 -QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
+D G + +++ + + I + + + I Q+ L + + +++ S R+K+
Sbjct: 1813 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRKKAL 1869
Query: 864 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 922
E + +++R ++ + L++ + +AS+P EP E+++KE +++ EEL +
Sbjct: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAVRRQ 1928
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ- 981
+ L+E G + V E Q + +W ++ + + AQI + +
Sbjct: 1929 AEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
Query: 982 -LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
+ ED+ +++++ P EI + + +V++ A D E++
Sbjct: 1977 TMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFEDLFK 2029
Query: 1041 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1100
+ + L K + Q +++ + S+ A + A+P + V L
Sbjct: 2030 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVERVKL 2070
Query: 1101 VTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLLDQV 1148
+ A+S+L+ + ++ F+R+ W WL+ +Q
Sbjct: 2071 --------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
++ ++ + +K+ +QD + QR+ + L + + ++S +A +I+
Sbjct: 2123 LRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQ 2178
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+++ + +W EV + L +R+++ L+E +D +++ EEA+ + A LE
Sbjct: 2179 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLE 2235
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKVHMI 1318
KE +++K+ + K L ++L Q + N+ +L S ++ K+
Sbjct: 2236 PGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2290
Query: 1319 TENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL---------- 1361
+ N W + + + E++ +E + + L+ L L WL
Sbjct: 2291 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2350
Query: 1362 -------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1405
TE A +V + ++ + L ++ + + ++ +DL E +A
Sbjct: 2351 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2410
Query: 1406 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
+ L + L + L E L + S L
Sbjct: 2411 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 2470
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETV 1525
+ + EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 2471 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP--------- 2521
Query: 1526 RIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKI 1585
LE+L + L + Q ++ + E + +W+++ H + ++++
Sbjct: 2522 ----------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
Query: 1586 DETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK 1645
+E L+ + EA +E + L QA SW+ G +D++Q + + K L ++ +
Sbjct: 2572 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQ 2630
Query: 1646 ENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLHEAH 1698
NV NDLA +L L Y+ E++N W+ + V +R L E H
Sbjct: 2631 TNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETH 2684
Query: 1699 R 1699
R
Sbjct: 2685 R 2685
Score = 107 bits (266), Expect = 2e-22
Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)
Query: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 412 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 468
Query: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 469 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 528
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 529 LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586
Query: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 587 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 629
Query: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 630 KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 675
Query: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
+ QI + E+ Q +R QI TV E + D
Sbjct: 676 TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 723
Query: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 724 --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 761
Query: 706 GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 752
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 762 --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 819
Query: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
W + +I F L + EQ T ENW E K LK
Sbjct: 820 N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 868
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
+D + + + + + I K + L + +++V + R+K L
Sbjct: 869 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928
Query: 863 EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 929 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 988
Query: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 989 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1046
Query: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 1047 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1102
Query: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1153
Query: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
+TV+L + +E+ +W++ ++ +
Sbjct: 1154 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1181
Query: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
+++ + + + K ++ +Q+ +++ L+T + N + A+ + +E +
Sbjct: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1240
Query: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
Query: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1301 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1355
Query: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1356 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1406
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1407 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1465
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1466 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1515
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
Query: 1567 VN--TEW 1571
+N TEW
Sbjct: 1576 MNVLTEW 1582
Score = 99.8 bits (247), Expect = 3e-20
Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)
Query: 775 WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 829
WL AE L+ + +I + E K +++ E + D + Q V + G ++I
Sbjct: 350 WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 408
Query: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 885
S+ + + +QE++ LN RW+ C +++ +K+ + ++ + L E WL E
Sbjct: 409 SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 466
Query: 886 ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 945
+ PL P E LK +++Q K+L E+L Q + L T V+V
Sbjct: 467 TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 523
Query: 946 KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1005
LE +LK +W + R ++ ++ + K + L E+ WLS
Sbjct: 524 ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 573
Query: 1006 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1052
+ + N+ + G D E ++Q K+ + ++ S Q L K K T
Sbjct: 574 KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 633
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
Q + L++ + W + L+Q+L ++ +TT S TQT + T VT I
Sbjct: 634 QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 690
Query: 1113 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1157
++ E+P + ++ + TEL W++ + V++S + G
Sbjct: 691 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 750
Query: 1158 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1216
+ D+ E K A ++ ++ +L++ +AQ L + N+ I E++ ++
Sbjct: 751 NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
Query: 1217 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1276
W E + L R L E + + ++ EQ+ A L+ P AI+ ++
Sbjct: 808 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 866
Query: 1277 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1336
K L Q ++ ++ L + ++ + V R
Sbjct: 867 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 924
Query: 1337 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
E L+ L ++ + W+ ++ET ++ Q + ++E G +
Sbjct: 925 EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 978
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q LQ ++ + L +++ + S+ + Q + + +W +L + +
Sbjct: 979 QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
LE ++ +++ +Q L W+ D L + P GD ++KQ R +++T
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
+P + S EG +K+ E PE ++ L + +E+NT+W+ +
Sbjct: 1098 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1137
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1632
+ + LE+ LQ+ E+ + QA E ++ ++ D LQ +E
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1194
Query: 1633 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1691
++K + E + V + + + ++ L LE L T ++ L + +
Sbjct: 1195 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1254
Query: 1692 RQLHE 1696
+ L E
Sbjct: 1255 KTLEE 1259
Score = 65.9 bits (159), Expect = 5e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 298 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 357
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 358 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 417
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 418 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 470
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 471 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 529
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 530 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 587
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 588 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644
Query: 1440 FKWSELRKK 1448
W L +K
Sbjct: 645 RCWDNLVQK 653
Score = 47.4 bits (111), Expect = 2e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
Query: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
Query: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
Query: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
Query: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
Query: 1676 LNTRWKLLQVAVEDR 1690
L RW + EDR
Sbjct: 532 LGDRWANICRWTEDR 546
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 1232 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1291
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 1292 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1351
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1411
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 1412 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1471
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 1472 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1531
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 1532 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1591
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 1592 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1651
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 1652 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1711
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 1712 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1771
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 1772 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1831
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 1832 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 1891
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 1892 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 1951
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 1952 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2011
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 2012 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2071
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 2072 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2131
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 2132 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2191
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 2192 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2251
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 2252 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2311
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 2312 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2371
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 2372 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2431
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 2432 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2491
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 2492 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2551
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 2552 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2611
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 2612 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2671
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 2672 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2731
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 2732 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2791
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 2792 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2851
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 2911
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 2912 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 2971
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 2972 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3031
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 3032 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3091
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 3092 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3151
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 3152 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3211
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 3212 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3271
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 3272 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3331
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 3332 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3391
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 3392 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3451
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 3452 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3511
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3512 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3562
Score = 209 bits (531), Expect = 3e-53
Identities = 384/1928 (19%), Positives = 787/1928 (40%), Gaps = 267/1928 (13%)
Query: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 796 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 848
Query: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 849 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908
Query: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 909 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968
Query: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 969 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088
Query: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1143
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ------------- 491
+LL LE + L E +F E+ G +E+ + D+L+
Sbjct: 1144 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200
Query: 492 ----QRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDL 545
Q +TD +E+ ++ L+T ++ ++L + RR+K LE S Q Q ++ L
Sbjct: 1201 RILAQTLTDGGVMDELINEE--LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 546 L-KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 604
+ + L I+K+LA+ D+ ++ +E QK + +L +
Sbjct: 1259 IQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------H 1297
Query: 605 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 664
+I L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 1298 EISLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESK 1352
Query: 665 QALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 724
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 1353 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1412
Query: 725 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 784
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L
Sbjct: 1413 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1472
Query: 785 KTQ----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
K +P N + ++ W K Q I +++ ++++ GE + K + +++++K
Sbjct: 1473 KRSAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDK 1529
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
L LN W V + + L E + + F ++++ W+ +AD + L+ +++
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKK 1585
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWI 959
+ ++K + +K L EL I +++ T + A + +E ++ + N ++
Sbjct: 1586 KPQQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1642
Query: 960 KVSRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ 1015
+S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 1643 AISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNE 1698
Query: 1016 EGPFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW-- 1066
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1699 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1758
Query: 1067 ----------------------------KAVNRLLQELRAKQPDL------APGLTTIGA 1092
+ + + +EL+ K+ +L A GL+ GA
Sbjct: 1759 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1818
Query: 1093 S----PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLM 1122
+ PTQ TV T V+T++ + +PS+ +
Sbjct: 1819 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1878
Query: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 1182
E+ T ++ L ++Q++ + + D ED+ + K L+Q +
Sbjct: 1879 TEI----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 1928
Query: 1183 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM-------- 1234
+ ++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 1929 I-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 1987
Query: 1235 --LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTN 1292
+K QWL EAEQ L + + E+W+ Y K+L + Q QT
Sbjct: 1988 YDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTV 2035
Query: 1293 VDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPL 1352
V N ++++ S D + ++N W+ + K++S+R+ LEE +L +F
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095
Query: 1353 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1412
DL +F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+
Sbjct: 2096 DLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLN 2148
Query: 1413 ENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 1471
E +L S S ++ L+ +L N +W ++ + + +EA +L L+
Sbjct: 2149 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 1472 E-------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKT 1513
+ LL+WL E+ Q G F AVQ KQ DV + L
Sbjct: 2209 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK 2268
Query: 1514 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQ 1563
++P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 2269 EKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQP 2325
Query: 1564 AEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLL 1623
T KL + S+ ++ + + E TD L L +VIK VGDL
Sbjct: 2326 VVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL- 2380
Query: 1624 IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWK 1681
+ + + + K KA ++ + + + A+ L + T +E + +W
Sbjct: 2381 -EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2439
Query: 1682 LLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDH 1741
+Q +++R +QL+E +D S +L + + K+ + T
Sbjct: 2440 EVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQ 2494
Query: 1742 PKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM 1801
K+TE Q DL + + + L L LL +A D H + +N
Sbjct: 2495 KKITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-A 2545
Query: 1802 DILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFK 1856
I ++ LE+ H L PL ++ L WL T T + R+L
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605
Query: 1857 TGIISLCK 1864
G+ L K
Sbjct: 2606 KGVKELMK 2613
Score = 186 bits (473), Expect = 2e-46
Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)
Query: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 636 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 695
Query: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 696 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 755
Query: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 756 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 813
Query: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 814 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 873
Query: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 874 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933
Query: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 934 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 991
Query: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 992 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1050
Query: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 1051 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1110
Query: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 1111 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1170
Query: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 1171 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230
Query: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1290
Query: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
+ DL E SL+ +K Q K+ A Q
Sbjct: 1291 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1317
Query: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 1318 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372
Query: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432
Query: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1492
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 1493 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1542
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1029
E + L + +K +E ++ ++H+ W+ L+ + + DV + + +
Sbjct: 1543 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1602
Query: 1030 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1085
+P V+ + +L + + V+ ++ +L+ + A++ ++ +A P +L
Sbjct: 1603 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1662
Query: 1086 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ I + Q V KE +K + L + +TD
Sbjct: 1663 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1722
Query: 1146 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1201
+ IK Q + L+D+ K+ + Q + Q ++L+ +++ K S E
Sbjct: 1723 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1782
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1243
R +I+ I + + +E L R+Q + +D S +W E
Sbjct: 1783 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1840
Query: 1244 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1282
+EE V+ + S+ Y + + + + E +QL
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900
Query: 1283 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
AKD L+Q +D+ + L+ + + K+ ++
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 1960
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1384
W ++K +R+ + + ++F D++ F WLTEAE RK ++ E+
Sbjct: 1961 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2013
Query: 1385 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1442
+ K +W ++LQ I V L+ ++I++ DA +LQ +L ++N +W
Sbjct: 2014 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2069
Query: 1443 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1502
E+ K+ + + LE + L E ++WL+ D+ S G + +K
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129
Query: 1503 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1562
V + EL ++ ++ ET L P+ PEE+ + L
Sbjct: 2130 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2170
Query: 1563 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1622
+ ++ N +W K++ + Q +I+ ++ L +L++ ++L+ +L + + ++
Sbjct: 2171 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2230
Query: 1623 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1682
Q+ V+ + + +V + + L P LEDL++ WK
Sbjct: 2231 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2288
Query: 1683 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1733
AV +++L D P AS T V P E AIS ++P + E
Sbjct: 2289 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2345
Query: 1734 TQTTCWDHPKMTELYQSLADLNNV 1757
+ TEL L+ L+ V
Sbjct: 2346 VPALADFNRAWTELTDWLSLLDQV 2369
Score = 156 bits (395), Expect = 2e-37
Identities = 332/1861 (17%), Positives = 729/1861 (39%), Gaps = 289/1861 (15%)
Query: 15 VRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 74
+R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS L
Sbjct: 819 MRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QSGLY 874
Query: 75 SHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRL 127
+++EM K ++ Q +I+ KKL ++ K + +
Sbjct: 875 YLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 934
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
Q K + EV + L + E+++ QL C L + ++ + V + G++I
Sbjct: 935 QTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKN 994
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
+ + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+ +
Sbjct: 995 EAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE 1054
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGEALK 295
E +R P L V K ++E ++++ +K +TE EALK
Sbjct: 1055 EEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALK 1114
Query: 296 TVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMETFDQ 342
L T + K L W ++ +A +WLN + K E
Sbjct: 1115 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 343 NVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANLMAN 400
+ I++ + + L+ SE P Q + + L ++++ + T + +
Sbjct: 1175 GAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHE 1233
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAEIQQ 459
+KL+E I ++ H I+ I K+L + +D + P EA+ Q
Sbjct: 1234 EAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQKIQ 1291
Query: 460 GVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRITDE 497
E ++M + N+G L Q+ N +QR+ +
Sbjct: 1292 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1351
Query: 498 RK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDIEKK 555
+ +E+K+ L+TK + ++SQ + + + K + + ++K ++KK
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKK 1410
Query: 556 LASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 602
P+ DER K+ E ++L+K + +R++ L+E AA +E
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 603 ----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE--------- 643
P+ + W + K + ++++ I V E V+ +
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL 1530
Query: 644 ------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
++ LE T+ + H+++ +++ + LL+ +
Sbjct: 1531 SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-- 1588
Query: 686 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 745
++E+ LK +K L ++D + + + R ++ +S+L+ ++ ++
Sbjct: 1589 ---QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS 1645
Query: 746 KMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL 804
++ + G+ +++ +F+ DI K+ E +Q + + K + + K++
Sbjct: 1646 --HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFNKDM 1693
Query: 805 -QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
+D G + +++ + + I + + + I Q+ L + + +++ S R+K+
Sbjct: 1694 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRKKAL 1750
Query: 864 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 922
E + +++R ++ + L++ + +AS+P EP E+++KE +++ EEL +
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAVRRQ 1809
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ- 981
+ L+E G + V E Q + +W ++ + + AQI + +
Sbjct: 1810 AEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 982 -LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
+ ED+ +++++ P EI + + +V++ A D E++
Sbjct: 1858 TMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFEDLFK 1910
Query: 1041 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1100
+ + L K + Q +++ + S+ A + A+P + V L
Sbjct: 1911 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVERVKL 1951
Query: 1101 VTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLLDQV 1148
+ A+S+L+ + ++ F+R+ W WL+ +Q
Sbjct: 1952 --------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
++ ++ + +K+ +QD + QR+ + L + + ++S +A +I+
Sbjct: 2004 LRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQ 2059
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+++ + +W EV + L +R+++ L+E +D +++ EEA+ + A LE
Sbjct: 2060 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLE 2116
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKVHMI 1318
KE +++K+ + K L ++L Q + N+ +L S ++ K+
Sbjct: 2117 PGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2171
Query: 1319 TENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL---------- 1361
+ N W + + + E++ +E + + L+ L L WL
Sbjct: 2172 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2231
Query: 1362 -------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1405
TE A +V + ++ + L ++ + + ++ +DL E +A
Sbjct: 2232 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2291
Query: 1406 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
+ L + L + L E L + S L
Sbjct: 2292 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 2351
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETV 1525
+ + EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 2352 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP--------- 2402
Query: 1526 RIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKI 1585
LE+L + L + Q ++ + E + +W+++ H + ++++
Sbjct: 2403 ----------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2452
Query: 1586 DETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK 1645
+E L+ + EA +E + L QA SW+ G +D++Q + + K L ++ +
Sbjct: 2453 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQ 2511
Query: 1646 ENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLHEAH 1698
NV NDLA +L L Y+ E++N W+ + V +R L E H
Sbjct: 2512 TNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETH 2565
Query: 1699 R 1699
R
Sbjct: 2566 R 2566
Score = 107 bits (266), Expect = 2e-22
Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)
Query: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 293 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 349
Query: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 350 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 409
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 410 LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467
Query: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 468 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 510
Query: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 511 KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 556
Query: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
+ QI + E+ Q +R QI TV E + D
Sbjct: 557 TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 604
Query: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 605 --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 642
Query: 706 GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 752
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 643 --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 700
Query: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
W + +I F L + EQ T ENW E K LK
Sbjct: 701 N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 749
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
+D + + + + + I K + L + +++V + R+K L
Sbjct: 750 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 809
Query: 863 EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 810 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 869
Query: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 870 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 927
Query: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 928 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 983
Query: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 984 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1034
Query: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
+TV+L + +E+ +W++ ++ +
Sbjct: 1035 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1062
Query: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
+++ + + + K ++ +Q+ +++ L+T + N + A+ + +E +
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1121
Query: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181
Query: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1182 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1236
Query: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1237 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1287
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1288 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1346
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1347 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1396
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1397 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1456
Query: 1567 VN--TEW 1571
+N TEW
Sbjct: 1457 MNVLTEW 1463
Score = 99.8 bits (247), Expect = 3e-20
Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)
Query: 775 WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 829
WL AE L+ + +I + E K +++ E + D + Q V + G ++I
Sbjct: 231 WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 289
Query: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 885
S+ + + +QE++ LN RW+ C +++ +K+ + ++ + L E WL E
Sbjct: 290 SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 347
Query: 886 ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 945
+ PL P E LK +++Q K+L E+L Q + L T V+V
Sbjct: 348 TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 404
Query: 946 KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1005
LE +LK +W + R ++ ++ + K + L E+ WLS
Sbjct: 405 ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 454
Query: 1006 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1052
+ + N+ + G D E ++Q K+ + ++ S Q L K K T
Sbjct: 455 KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 514
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
Q + L++ + W + L+Q+L ++ +TT S TQT + T VT I
Sbjct: 515 QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 571
Query: 1113 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1157
++ E+P + ++ + TEL W++ + V++S + G
Sbjct: 572 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 631
Query: 1158 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1216
+ D+ E K A ++ ++ +L++ +AQ L + N+ I E++ ++
Sbjct: 632 NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688
Query: 1217 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1276
W E + L R L E + + ++ EQ+ A L+ P AI+ ++
Sbjct: 689 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747
Query: 1277 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1336
K L Q ++ ++ L + ++ + V R
Sbjct: 748 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 805
Query: 1337 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
E L+ L ++ + W+ ++ET ++ Q + ++E G +
Sbjct: 806 EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 859
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q LQ ++ + L +++ + S+ + Q + + +W +L + +
Sbjct: 860 QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
LE ++ +++ +Q L W+ D L + P GD ++KQ R +++T
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
+P + S EG +K+ E PE ++ L + +E+NT+W+ +
Sbjct: 979 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1018
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1632
+ + LE+ LQ+ E+ + QA E ++ ++ D LQ +E
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1075
Query: 1633 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1691
++K + E + V + + + ++ L LE L T ++ L + +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 1692 RQLHE 1696
+ L E
Sbjct: 1136 KTLEE 1140
Score = 65.9 bits (159), Expect = 5e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 179 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 238
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 239 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 298
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 299 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 351
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 352 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 410
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 411 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 468
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 469 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525
Query: 1440 FKWSELRKK 1448
W L +K
Sbjct: 526 RCWDNLVQK 534
Score = 47.4 bits (111), Expect = 2e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 140 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 199
Query: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 200 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 260 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 301
Query: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 302 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 356
Query: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 357 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 412
Query: 1676 LNTRWKLLQVAVEDR 1690
L RW + EDR
Sbjct: 413 LGDRWANICRWTEDR 427
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 1355 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1414
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 1415 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1594
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 1595 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1654
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1714
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 1715 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1774
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 1775 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1834
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1954
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 1955 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2014
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 2015 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2074
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 2075 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2134
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 2135 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2194
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 2195 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2254
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 2255 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2314
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 2315 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2374
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 2375 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2434
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 2435 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2494
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 2495 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2554
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 2555 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2614
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 2615 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2674
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 2675 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2734
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 2735 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2794
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 2795 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 3034
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 3035 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 3094
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 3095 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3154
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 3155 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3214
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 3215 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3274
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 3275 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3334
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 3335 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3394
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 3395 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3454
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 3455 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3514
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 3515 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3574
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 3575 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3634
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3635 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685
Score = 209 bits (531), Expect = 3e-53
Identities = 384/1928 (19%), Positives = 787/1928 (40%), Gaps = 267/1928 (13%)
Query: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 919 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 971
Query: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 972 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
Query: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
Query: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
Query: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1266
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ------------- 491
+LL LE + L E +F E+ G +E+ + D+L+
Sbjct: 1267 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1323
Query: 492 ----QRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDL 545
Q +TD +E+ ++ L+T ++ ++L + RR+K LE S Q Q ++ L
Sbjct: 1324 RILAQTLTDGGVMDELINEE--LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381
Query: 546 L-KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 604
+ + L I+K+LA+ D+ ++ +E QK + +L +
Sbjct: 1382 IQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------H 1420
Query: 605 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 664
+I L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 1421 EISLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESK 1475
Query: 665 QALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 724
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 1476 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1535
Query: 725 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 784
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L
Sbjct: 1536 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595
Query: 785 KTQ----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
K +P N + ++ W K Q I +++ ++++ GE + K + +++++K
Sbjct: 1596 KRSAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDK 1652
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 900
L LN W V + + L E + + F ++++ W+ +AD + L+ +++
Sbjct: 1653 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKK 1708
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWI 959
+ ++K + +K L EL I +++ T + A + +E ++ + N ++
Sbjct: 1709 KPQQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1765
Query: 960 KVSRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ 1015
+S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 1766 AISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNE 1821
Query: 1016 EGPFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW-- 1066
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881
Query: 1067 ----------------------------KAVNRLLQELRAKQPDL------APGLTTIGA 1092
+ + + +EL+ K+ +L A GL+ GA
Sbjct: 1882 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1941
Query: 1093 S----PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLM 1122
+ PTQ TV T V+T++ + +PS+ +
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001
Query: 1123 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 1182
E+ T ++ L ++Q++ + + D ED+ + K L+Q +
Sbjct: 2002 TEI----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2051
Query: 1183 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM-------- 1234
+ ++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 2052 I-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 2110
Query: 1235 --LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTN 1292
+K QWL EAEQ L + + E+W+ Y K+L + Q QT
Sbjct: 2111 YDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTV 2158
Query: 1293 VDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPL 1352
V N ++++ S D + ++N W+ + K++S+R+ LEE +L +F
Sbjct: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
Query: 1353 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1412
DL +F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+
Sbjct: 2219 DLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLN 2271
Query: 1413 ENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 1471
E +L S S ++ L+ +L N +W ++ + + +EA +L L+
Sbjct: 2272 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2331
Query: 1472 E-------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKT 1513
+ LL+WL E+ Q G F AVQ KQ DV + L
Sbjct: 2332 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK 2391
Query: 1514 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQ 1563
++P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 2392 EKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQP 2448
Query: 1564 AEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLL 1623
T KL + S+ ++ + + E TD L L +VIK VGDL
Sbjct: 2449 VVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL- 2503
Query: 1624 IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWK 1681
+ + + + K KA ++ + + + A+ L + T +E + +W
Sbjct: 2504 -EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2562
Query: 1682 LLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDH 1741
+Q +++R +QL+E +D S +L + + K+ + T
Sbjct: 2563 EVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQ 2617
Query: 1742 PKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM 1801
K+TE Q DL + + + L L LL +A D H + +N
Sbjct: 2618 KKITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-A 2668
Query: 1802 DILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFK 1856
I ++ LE+ H L PL ++ L WL T T + R+L
Sbjct: 2669 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2728
Query: 1857 TGIISLCK 1864
G+ L K
Sbjct: 2729 KGVKELMK 2736
Score = 186 bits (473), Expect = 2e-46
Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)
Query: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 759 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 818
Query: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 819 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878
Query: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 879 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 936
Query: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 937 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996
Query: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 997 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056
Query: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 1057 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1114
Query: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1173
Query: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 1174 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
Query: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1293
Query: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
Query: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1413
Query: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
+ DL E SL+ +K Q K+ A Q
Sbjct: 1414 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1440
Query: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 1441 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1495
Query: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 1496 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1555
Query: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 1556 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1615
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 1616 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1665
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1029
E + L + +K +E ++ ++H+ W+ L+ + + DV + + +
Sbjct: 1666 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1725
Query: 1030 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1085
+P V+ + +L + + V+ ++ +L+ + A++ ++ +A P +L
Sbjct: 1726 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1785
Query: 1086 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ I + Q V KE +K + L + +TD
Sbjct: 1786 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1845
Query: 1146 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1201
+ IK Q + L+D+ K+ + Q + Q ++L+ +++ K S E
Sbjct: 1846 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1905
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1243
R +I+ I + + +E L R+Q + +D S +W E
Sbjct: 1906 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1963
Query: 1244 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1282
+EE V+ + S+ Y + + + + E +QL
Sbjct: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2023
Query: 1283 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
AKD L+Q +D+ + L+ + + K+ ++
Sbjct: 2024 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2083
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1384
W ++K +R+ + + ++F D++ F WLTEAE RK ++ E+
Sbjct: 2084 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2136
Query: 1385 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1442
+ K +W ++LQ I V L+ ++I++ DA +LQ +L ++N +W
Sbjct: 2137 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2192
Query: 1443 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1502
E+ K+ + + LE + L E ++WL+ D+ S G + +K
Sbjct: 2193 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2252
Query: 1503 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1562
V + EL ++ ++ ET L P+ PEE+ + L
Sbjct: 2253 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2293
Query: 1563 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1622
+ ++ N +W K++ + Q +I+ ++ L +L++ ++L+ +L + + ++
Sbjct: 2294 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2353
Query: 1623 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1682
Q+ V+ + + +V + + L P LEDL++ WK
Sbjct: 2354 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2411
Query: 1683 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1733
AV +++L D P AS T V P E AIS ++P + E
Sbjct: 2412 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2468
Query: 1734 TQTTCWDHPKMTELYQSLADLNNV 1757
+ TEL L+ L+ V
Sbjct: 2469 VPALADFNRAWTELTDWLSLLDQV 2492
Score = 156 bits (395), Expect = 2e-37
Identities = 332/1861 (17%), Positives = 729/1861 (39%), Gaps = 289/1861 (15%)
Query: 15 VRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 74
+R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS L
Sbjct: 942 MRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QSGLY 997
Query: 75 SHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRL 127
+++EM K ++ Q +I+ KKL ++ K + +
Sbjct: 998 YLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1057
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
Q K + EV + L + E+++ QL C L + ++ + V + G++I
Sbjct: 1058 QTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKN 1117
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
+ + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+ +
Sbjct: 1118 EAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE 1177
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGEALK 295
E +R P L V K ++E ++++ +K +TE EALK
Sbjct: 1178 EEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALK 1237
Query: 296 TVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMETFDQ 342
L T + K L W ++ +A +WLN + K E
Sbjct: 1238 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1297
Query: 343 NVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANLMAN 400
+ I++ + + L+ SE P Q + + L ++++ + T + +
Sbjct: 1298 GAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHE 1356
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAEIQQ 459
+KL+E I ++ H I+ I K+L + +D + P EA+ Q
Sbjct: 1357 EAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQKIQ 1414
Query: 460 GVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRITDE 497
E ++M + N+G L Q+ N +QR+ +
Sbjct: 1415 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
Query: 498 RK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDIEKK 555
+ +E+K+ L+TK + ++SQ + + + K + + ++K ++KK
Sbjct: 1475 KMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKK 1533
Query: 556 LASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 602
P+ DER K+ E ++L+K + +R++ L+E AA +E
Sbjct: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Query: 603 ----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE--------- 643
P+ + W + K + ++++ I V E V+ +
Sbjct: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL 1653
Query: 644 ------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
++ LE T+ + H+++ +++ + LL+ +
Sbjct: 1654 SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-- 1711
Query: 686 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 745
++E+ LK +K L ++D + + + R ++ +S+L+ ++ ++
Sbjct: 1712 ---QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS 1768
Query: 746 KMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKEL 804
++ + G+ +++ +F+ DI K+ E +Q + + K + + K++
Sbjct: 1769 --HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFNKDM 1816
Query: 805 -QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
+D G + +++ + + I + + + I Q+ L + + +++ S R+K+
Sbjct: 1817 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRKKAL 1873
Query: 864 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 922
E + +++R ++ + L++ + +AS+P EP E+++KE +++ EEL +
Sbjct: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAVRRQ 1932
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ- 981
+ L+E G + V E Q + +W ++ + + AQI + +
Sbjct: 1933 AEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
Query: 982 -LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
+ ED+ +++++ P EI + + +V++ A D E++
Sbjct: 1981 TMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFEDLFK 2033
Query: 1041 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1100
+ + L K + Q +++ + S+ A + A+P + V L
Sbjct: 2034 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVERVKL 2074
Query: 1101 VTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLLDQV 1148
+ A+S+L+ + ++ F+R+ W WL+ +Q
Sbjct: 2075 --------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
++ ++ + +K+ +QD + QR+ + L + + ++S +A +I+
Sbjct: 2127 LRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQ 2182
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+++ + +W EV + L +R+++ L+E +D +++ EEA+ + A LE
Sbjct: 2183 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLE 2239
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKVHMI 1318
KE +++K+ + K L ++L Q + N+ +L S ++ K+
Sbjct: 2240 PGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2294
Query: 1319 TENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL---------- 1361
+ N W + + + E++ +E + + L+ L L WL
Sbjct: 2295 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY 2354
Query: 1362 -------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1405
TE A +V + ++ + L ++ + + ++ +DL E +A
Sbjct: 2355 NQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2414
Query: 1406 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
+ L + L + L E L + S L
Sbjct: 2415 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALAD 2474
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETV 1525
+ + EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 2475 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP--------- 2525
Query: 1526 RIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKI 1585
LE+L + L + Q ++ + E + +W+++ H + ++++
Sbjct: 2526 ----------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
Query: 1586 DETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK 1645
+E L+ + EA +E + L QA SW+ G +D++Q + + K L ++ +
Sbjct: 2576 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQ 2634
Query: 1646 ENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLHEAH 1698
NV NDLA +L L Y+ E++N W+ + V +R L E H
Sbjct: 2635 TNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETH 2688
Query: 1699 R 1699
R
Sbjct: 2689 R 2689
Score = 107 bits (266), Expect = 2e-22
Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)
Query: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 416 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 472
Query: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 473 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 532
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 533 LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590
Query: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 591 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 633
Query: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 634 KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 679
Query: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
+ QI + E+ Q +R QI TV E + D
Sbjct: 680 TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 727
Query: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 728 --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 765
Query: 706 GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 752
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 766 --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 823
Query: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
W + +I F L + EQ T ENW E K LK
Sbjct: 824 N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 872
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
+D + + + + + I K + L + +++V + R+K L
Sbjct: 873 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 932
Query: 863 EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 933 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 992
Query: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 993 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1050
Query: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 1051 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1106
Query: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1157
Query: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
+TV+L + +E+ +W++ ++ +
Sbjct: 1158 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1185
Query: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
+++ + + + K ++ +Q+ +++ L+T + N + A+ + +E +
Sbjct: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1244
Query: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
Query: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1305 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1359
Query: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1360 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1410
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1411 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1469
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1470 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1519
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1520 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579
Query: 1567 VN--TEW 1571
+N TEW
Sbjct: 1580 MNVLTEW 1586
Score = 99.8 bits (247), Expect = 3e-20
Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)
Query: 775 WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 829
WL AE L+ + +I + E K +++ E + D + Q V + G ++I
Sbjct: 354 WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 412
Query: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 885
S+ + + +QE++ LN RW+ C +++ +K+ + ++ + L E WL E
Sbjct: 413 SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 470
Query: 886 ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 945
+ PL P E LK +++Q K+L E+L Q + L T V+V
Sbjct: 471 TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 527
Query: 946 KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1005
LE +LK +W + R ++ ++ + K + L E+ WLS
Sbjct: 528 ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 577
Query: 1006 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1052
+ + N+ + G D E ++Q K+ + ++ S Q L K K T
Sbjct: 578 KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 637
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
Q + L++ + W + L+Q+L ++ +TT S TQT + T VT I
Sbjct: 638 QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 694
Query: 1113 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1157
++ E+P + ++ + TEL W++ + V++S + G
Sbjct: 695 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 754
Query: 1158 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1216
+ D+ E K A ++ ++ +L++ +AQ L + N+ I E++ ++
Sbjct: 755 NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811
Query: 1217 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1276
W E + L R L E + + ++ EQ+ A L+ P AI+ ++
Sbjct: 812 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 870
Query: 1277 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1336
K L Q ++ ++ L + ++ + V R
Sbjct: 871 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 928
Query: 1337 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
E L+ L ++ + W+ ++ET ++ Q + ++E G +
Sbjct: 929 EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 982
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Q LQ ++ + L +++ + S+ + Q + + +W +L + +
Sbjct: 983 QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
LE ++ +++ +Q L W+ D L + P GD ++KQ R +++T
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1101
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
+P + S EG +K+ E PE ++ L + +E+NT+W+ +
Sbjct: 1102 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1141
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1632
+ + LE+ LQ+ E+ + QA E ++ ++ D LQ +E
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1198
Query: 1633 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1691
++K + E + V + + + ++ L LE L T ++ L + +
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1258
Query: 1692 RQLHE 1696
+ L E
Sbjct: 1259 KTLEE 1263
Score = 65.9 bits (159), Expect = 5e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 302 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 361
Query: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 362 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 421
Query: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 422 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 474
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 475 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 533
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 534 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 591
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 592 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648
Query: 1440 FKWSELRKK 1448
W L +K
Sbjct: 649 RCWDNLVQK 657
Score = 47.4 bits (111), Expect = 2e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
Query: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
Query: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
Query: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
Query: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
Query: 1676 LNTRWKLLQVAVEDR 1690
L RW + EDR
Sbjct: 536 LGDRWANICRWTEDR 550
>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
Length = 2344
Score = 4597 bits (11924), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2329/2331 (99%)
Query: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
+ AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 14 FLNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 73
Query: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 74 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 133
Query: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 134 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
Query: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 194 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 253
Query: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 254 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 313
Query: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 314 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 373
Query: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 374 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 433
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 434 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 493
Query: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 494 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 553
Query: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 554 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 613
Query: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 614 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 674 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 733
Query: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 734 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 793
Query: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 794 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 853
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 854 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 913
Query: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 914 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
Query: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 974 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1033
Query: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 1034 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1153
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 1154 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1213
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 1214 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1693
Query: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 1694 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1753
Query: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 1754 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1813
Query: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 1814 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1873
Query: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 1874 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1933
Query: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 1934 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1993
Query: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 1994 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2053
Query: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 2054 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2113
Query: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 2114 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2173
Query: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 2174 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2233
Query: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 2234 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2293
Query: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2294 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
>gi|5032293 dystrophin Dp140 isoform [Homo sapiens]
Length = 1225
Score = 2452 bits (6355), Expect = 0.0
Identities = 1225/1225 (100%), Positives = 1225/1225 (100%)
Query: 1117 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1176
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 1177 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1236
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 1237 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 1297 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1356
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 1357 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1416
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 1417 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1476
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 1477 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 1597 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1656
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 1657 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1716
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 1717 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1776
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 1777 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1836
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 1837 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1896
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 1897 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1956
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 1957 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2016
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 2017 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2076
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960
Query: 2077 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2136
APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020
Query: 2137 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2196
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080
Query: 2197 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2256
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140
Query: 2257 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2316
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200
Query: 2317 EQLNNSFPSSRGRNTPGKPMREDTM 2341
EQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1201 EQLNNSFPSSRGRNTPGKPMREDTM 1225
Score = 100 bits (249), Expect = 2e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 719
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 720 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 777
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 778 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 827
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 828 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 887
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 888 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 940
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 941 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1000
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 1001 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1060
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 1061 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1117
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 1118 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1171
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 1172 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1231
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 1232 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1286
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 1287 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1337
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 73.6 bits (179), Expect = 2e-12
Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)
Query: 239 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 298
LT+WL+ D + + + G +++ + KAT +++E+++ L+ + + LK
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 299 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 356
+E T++ D++ + + W V + L E K + + + + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 357 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 410
L ES K+ P Q+K K+L +L + VD D A L+ + + V
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200
Query: 411 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 467
+N + +I R+ +A++ + L+QF D++K L L EAE V L++
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259
Query: 468 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 513
+ + ED++G VKEL+++ +LQ I DE ++ ++ + LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318
Query: 514 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 565
+ + S+ RKK+L I S QW + +LL L + +L+ P D
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+++ + + K EL E E L K ++E + R
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
N ++ +R++ V TE L + + + +I + L E+++ + DL + E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 686 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 740
+ + + ++ DSLQ ++ + + ++ + V L L+ L Q
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552
Query: 741 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 795
E +N +K Q + V + H D A Q T + WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604
Score = 52.4 bits (124), Expect = 5e-06
Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 47 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 93
K + D D +M + + DL LEE+ K +EA
Sbjct: 34 KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93
Query: 94 -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 151
+R+ +Q D Q+ LQ+ + + + + + +E++ +L + + L + +
Sbjct: 94 IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153
Query: 152 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 211
+ +Q ++ L K L + ++ V++ ++++ ++ +++ + + +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213
Query: 212 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 270
+V+ER+ LE+ +L ++ ++ WL T+ E T + E + G
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271
Query: 271 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 321
K K+ + + +++ T+V + L+++ G + L++ +L +N W +
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 373
++ + L + ++ + W+ D DE ++ P Q++ DV
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388
Query: 374 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 431
+ K EL P + ST + + + + KL EP+ R ++ ++
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445
Query: 432 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
K+ E+ N++ +KL NL D+ + ++E E ++EL + D L
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487
Query: 492 QRITDERKREEIK 504
++ R+ E IK
Sbjct: 488 LKL---RQAEVIK 497
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 984 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156
>gi|5032309 dystrophin Dp140b isoform [Homo sapiens]
Length = 1243
Score = 2427 bits (6289), Expect = 0.0
Identities = 1213/1214 (99%), Positives = 1213/1214 (99%)
Query: 1117 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1176
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 1177 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1236
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 1237 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 1297 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1356
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 1357 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1416
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 1417 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1476
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 1477 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 1597 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1656
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 1657 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1716
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 1717 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1776
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 1777 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1836
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 1837 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1896
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 1897 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1956
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 1957 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2016
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 2017 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2076
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960
Query: 2077 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2136
APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020
Query: 2137 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2196
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080
Query: 2197 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2256
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140
Query: 2257 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2316
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200
Query: 2317 EQLNNSFPSSRGRN 2330
EQLNNSFPSSRG N
Sbjct: 1201 EQLNNSFPSSRGHN 1214
Score = 100 bits (249), Expect = 2e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 719
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 720 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 777
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 778 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 827
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 828 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 887
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 888 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 940
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 941 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1000
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 1001 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1060
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 1061 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1117
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 1118 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1171
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 1172 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1231
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 1232 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1286
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 1287 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1337
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 73.6 bits (179), Expect = 2e-12
Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)
Query: 239 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 298
LT+WL+ D + + + G +++ + KAT +++E+++ L+ + + LK
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 299 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 356
+E T++ D++ + + W V + L E K + + + + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 357 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 410
L ES K+ P Q+K K+L +L + VD D A L+ + + V
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200
Query: 411 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 467
+N + +I R+ +A++ + L+QF D++K L L EAE V L++
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259
Query: 468 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 513
+ + ED++G VKEL+++ +LQ I DE ++ ++ + LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318
Query: 514 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 565
+ + S+ RKK+L I S QW + +LL L + +L+ P D
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+++ + + K EL E E L K ++E + R
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
N ++ +R++ V TE L + + + +I + L E+++ + DL + E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 686 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 740
+ + + ++ DSLQ ++ + + ++ + V L L+ L Q
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552
Query: 741 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 795
E +N +K Q + V + H D A Q T + WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604
Score = 52.4 bits (124), Expect = 5e-06
Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 47 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 93
K + D D +M + + DL LEE+ K +EA
Sbjct: 34 KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93
Query: 94 -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 151
+R+ +Q D Q+ LQ+ + + + + + +E++ +L + + L + +
Sbjct: 94 IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153
Query: 152 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 211
+ +Q ++ L K L + ++ V++ ++++ ++ +++ + + +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213
Query: 212 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 270
+V+ER+ LE+ +L ++ ++ WL T+ E T + E + G
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271
Query: 271 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 321
K K+ + + +++ T+V + L+++ G + L++ +L +N W +
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 373
++ + L + ++ + W+ D DE ++ P Q++ DV
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388
Query: 374 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 431
+ K EL P + ST + + + + KL EP+ R ++ ++
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445
Query: 432 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
K+ E+ N++ +KL NL D+ + ++E E ++EL + D L
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487
Query: 492 QRITDERKREEIK 504
++ R+ E IK
Sbjct: 488 LKL---RQAEVIK 497
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 984 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156
>gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]
Length = 1230
Score = 2390 bits (6193), Expect = 0.0
Identities = 1200/1214 (98%), Positives = 1200/1214 (98%), Gaps = 13/1214 (1%)
Query: 1117 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1176
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 1177 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1236
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 1237 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 1297 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1356
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 1357 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1416
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 1417 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1476
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 1477 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 1597 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1656
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 1657 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1716
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 1717 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1776
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 1777 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1836
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 1837 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1896
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 1897 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1956
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 1957 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2016
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 2017 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2076
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET------------ 948
Query: 2077 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2136
PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 949 -PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1007
Query: 2137 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2196
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1008 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1067
Query: 2197 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2256
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1068 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1127
Query: 2257 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2316
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1128 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1187
Query: 2317 EQLNNSFPSSRGRN 2330
EQLNNSFPSSRG N
Sbjct: 1188 EQLNNSFPSSRGHN 1201
Score = 100 bits (249), Expect = 2e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 719
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 720 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 777
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 778 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 827
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 828 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 887
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 888 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 940
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 941 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1000
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 1001 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1060
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 1061 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1117
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 1118 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1171
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 1172 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1231
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 1232 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1286
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 1287 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1337
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 73.6 bits (179), Expect = 2e-12
Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)
Query: 239 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 298
LT+WL+ D + + + G +++ + KAT +++E+++ L+ + + LK
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 299 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 356
+E T++ D++ + + W V + L E K + + + + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 357 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 410
L ES K+ P Q+K K+L +L + VD D A L+ + + V
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200
Query: 411 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 467
+N + +I R+ +A++ + L+QF D++K L L EAE V L++
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259
Query: 468 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 513
+ + ED++G VKEL+++ +LQ I DE ++ ++ + LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318
Query: 514 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 565
+ + S+ RKK+L I S QW + +LL L + +L+ P D
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+++ + + K EL E E L K ++E + R
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
N ++ +R++ V TE L + + + +I + L E+++ + DL + E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 686 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 740
+ + + ++ DSLQ ++ + + ++ + V L L+ L Q
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552
Query: 741 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 795
E +N +K Q + V + H D A Q T + WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604
Score = 52.4 bits (124), Expect = 5e-06
Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 47 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 93
K + D D +M + + DL LEE+ K +EA
Sbjct: 34 KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93
Query: 94 -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 151
+R+ +Q D Q+ LQ+ + + + + + +E++ +L + + L + +
Sbjct: 94 IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153
Query: 152 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 211
+ +Q ++ L K L + ++ V++ ++++ ++ +++ + + +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213
Query: 212 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 270
+V+ER+ LE+ +L ++ ++ WL T+ E T + E + G
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271
Query: 271 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 321
K K+ + + +++ T+V + L+++ G + L++ +L +N W +
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 373
++ + L + ++ + W+ D DE ++ P Q++ DV
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388
Query: 374 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 431
+ K EL P + ST + + + + KL EP+ R ++ ++
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445
Query: 432 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
K+ E+ N++ +KL NL D+ + ++E E ++EL + D L
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487
Query: 492 QRITDERKREEIK 504
++ R+ E IK
Sbjct: 488 LKL---RQAEVIK 497
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 971 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1029
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1030 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1085
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1086 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1143
>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
Length = 1133
Score = 1908 bits (4943), Expect = 0.0
Identities = 970/1073 (90%), Positives = 988/1073 (92%), Gaps = 52/1073 (4%)
Query: 1117 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1176
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 1177 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1236
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 1237 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 1297 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1356
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 1357 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1416
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 1417 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1476
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 1477 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 1597 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1656
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 1657 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1716
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 1717 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1776
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 1777 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1836
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 1837 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1896
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 1897 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1956
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 1957 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2016
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 2017 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2076
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET +
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETNL---------- 950
Query: 2077 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2136
Q +D + EH L+ SP E +
Sbjct: 951 ------QAEYDRLKQQHEHKG-------------LSPLPSPPEMMP-------------- 977
Query: 2137 QDSPLSQPRSPAQILISLES----EERGELERILADLEEENRNLQAEYDRLKQ 2185
+ P+SP + E+ + +G LE + LE+ N+ L+++ RL+Q
Sbjct: 978 -----TSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQ 1025
Score = 306 bits (785), Expect = 1e-82
Identities = 158/164 (96%), Positives = 159/164 (96%), Gaps = 2/164 (1%)
Query: 2169 LEEENR--NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 2226
LE +N NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
Sbjct: 941 LEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 1000
Query: 2227 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 2286
RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
Sbjct: 1001 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 1060
Query: 2287 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2330
VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 1061 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 1104
Score = 100 bits (249), Expect = 2e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 719
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 720 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 777
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 778 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 827
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 828 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 887
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 888 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 940
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 941 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1000
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 1001 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1060
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 1061 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1117
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 1118 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1171
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 1172 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1231
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 1232 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1286
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 1287 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1337
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 73.6 bits (179), Expect = 2e-12
Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)
Query: 239 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 298
LT+WL+ D + + + G +++ + KAT +++E+++ L+ + + LK
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 299 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 356
+E T++ D++ + + W V + L E K + + + + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 357 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 410
L ES K+ P Q+K K+L +L + VD D A L+ + + V
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200
Query: 411 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 467
+N + +I R+ +A++ + L+QF D++K L L EAE V L++
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259
Query: 468 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 513
+ + ED++G VKEL+++ +LQ I DE ++ ++ + LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318
Query: 514 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 565
+ + S+ RKK+L I S QW + +LL L + +L+ P D
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+++ + + K EL E E L K ++E + R
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
N ++ +R++ V TE L + + + +I + L E+++ + DL + E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 686 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 740
+ + + ++ DSLQ ++ + + ++ + V L L+ L Q
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552
Query: 741 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 795
E +N +K Q + V + H D A Q T + WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604
Score = 52.4 bits (124), Expect = 5e-06
Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 47 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 93
K + D D +M + + DL LEE+ K +EA
Sbjct: 34 KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93
Query: 94 -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 151
+R+ +Q D Q+ LQ+ + + + + + +E++ +L + + L + +
Sbjct: 94 IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153
Query: 152 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 211
+ +Q ++ L K L + ++ V++ ++++ ++ +++ + + +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213
Query: 212 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 270
+V+ER+ LE+ +L ++ ++ WL T+ E T + E + G
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271
Query: 271 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 321
K K+ + + +++ T+V + L+++ G + L++ +L +N W +
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 373
++ + L + ++ + W+ D DE ++ P Q++ DV
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388
Query: 374 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 431
+ K EL P + ST + + + + KL EP+ R ++ ++
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445
Query: 432 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
K+ E+ N++ +KL NL D+ + ++E E ++EL + D L
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487
Query: 492 QRITDERKREEIK 504
++ R+ E IK
Sbjct: 488 LKL---RQAEVIK 497
>gi|5032295 dystrophin Dp116 isoform [Homo sapiens]
Length = 956
Score = 1907 bits (4939), Expect = 0.0
Identities = 946/947 (99%), Positives = 947/947 (100%)
Query: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
+DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS
Sbjct: 10 KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK
Sbjct: 70 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 129
Query: 1515 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1574
EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL
Sbjct: 130 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 189
Query: 1575 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 1634
NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV
Sbjct: 190 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 249
Query: 1635 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 1694
KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL
Sbjct: 250 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 309
Query: 1695 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 1754
HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL
Sbjct: 310 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 369
Query: 1755 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 1814
NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY
Sbjct: 370 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 429
Query: 1815 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 1874
DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL
Sbjct: 430 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 489
Query: 1875 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 1934
FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA
Sbjct: 490 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 549
Query: 1935 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 1994
ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ
Sbjct: 550 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 609
Query: 1995 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 2054
SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ
Sbjct: 610 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 669
Query: 2055 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 2114
TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS
Sbjct: 670 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 729
Query: 2115 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 2174
ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
Sbjct: 730 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 789
Query: 2175 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 2234
NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI
Sbjct: 790 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 849
Query: 2235 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 2294
LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD
Sbjct: 850 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 909
Query: 2295 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 910 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 956
Score = 67.8 bits (164), Expect = 1e-10
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ-------------- 1182
EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 87 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 146
Query: 1183 -----LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD 1237
LE+L + L + Q ++ + E + +W+++ H + +++++E L+
Sbjct: 147 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 206
Query: 1238 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
+ EA +E + L QA SW+ G +D++Q + + K L ++ + NV
Sbjct: 207 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 266
Query: 1297 NDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 1345
NDLA +L L Y+ E++N W+ + V +R L E HR
Sbjct: 267 NDLARQLTTLGIQLSPYNLSTL-------EDLNTRWKLLQVAVEDRVRQLHEAHR 314
Score = 60.5 bits (145), Expect = 2e-08
Identities = 79/375 (21%), Positives = 152/375 (40%), Gaps = 34/375 (9%)
Query: 799 WYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRWQEVCKQLSD 857
+++K+LQ I V L+ ++I++ DA +LQ +L ++N +W E+ K+ +
Sbjct: 7 YHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 66
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV-KLLVEEL 916
+ LE + L E ++WL+ D+ S G + +K V + EL
Sbjct: 67 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126
Query: 917 PLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LENKLKQTNLQW 958
++ ++ ET L P+ PEE+ + L + ++ N +W
Sbjct: 127 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 186
Query: 959 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1018
K++ + Q +I+ ++ L +L++ ++L+ +L + + ++ Q+
Sbjct: 187 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHL 246
Query: 1019 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK----AVNRLL 1073
V+ + + +V + + L P LEDL++ WK AV +
Sbjct: 247 EKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRV 306
Query: 1074 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNR 1133
++L D P AS T V P E AIS ++P + E +
Sbjct: 307 RQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHETQTTCWDHP 357
Query: 1134 AWTELTDWLSLLDQV 1148
TEL L+ L+ V
Sbjct: 358 KMTELYQSLADLNNV 372
Score = 56.2 bits (134), Expect = 4e-07
Identities = 62/314 (19%), Positives = 132/314 (42%), Gaps = 33/314 (10%)
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVE----RVKLQEALSQLDFQWEKVNKMYKDR 751
++KD + D+ H+ + + +E V LQ L ++F+W ++ K +
Sbjct: 8 HVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 67
Query: 752 QGRFDRSVEKWRRFHYDIKIFNQWL-TEAEQFLRKTQI--------PENWEHAKYKWYLK 802
+ + S ++W+R H ++ WL + ++ R+ I +N H +K LK
Sbjct: 68 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 127
Query: 803 ELQDGIGQRQTVVRTLNATG-----EEIIQ--------QSSKTDASILQEKLGSLNLRWQ 849
+ I VR E++ Q + ++ +L+++ +N W+
Sbjct: 128 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 187
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLE 907
++ +D +++++E L E Q +E L L +A+ I P+ L++ LE
Sbjct: 188 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 247
Query: 908 QVKLLVEEL-PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 966
+VK L E+ PL++ + + + +SP LE+ N +W + A+
Sbjct: 248 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 303
Query: 967 EKQGEIEAQIKDLG 980
++ ++ +D G
Sbjct: 304 DRVRQLHEAHRDFG 317
Score = 40.0 bits (92), Expect = 0.027
Identities = 70/329 (21%), Positives = 138/329 (41%), Gaps = 52/329 (15%)
Query: 1284 KDLR-QWQTNVDVANDL---ALKLLRDYS-ADDTRKVHMITENINASWRSIHKRVSEREA 1338
KDL+ + + + DV ++L + K+LR +DD + +N+N W + K+ +
Sbjct: 10 KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69
Query: 1339 ALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 1398
LE + ++ L L++ L WL + + +R+ + D V++ + +
Sbjct: 70 HLEASSDQWKRLHLSLQELLVWLQLKD------DELSRQAPIGGDFPAVQKQNDVHRAFK 123
Query: 1399 GEIEAHTDVYHNLDENSQKIL--RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN--IRS 1454
E++ V + E + L + LEG + R L E R +++ +R
Sbjct: 124 RELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP------PEERAQNVTRLLRK 177
Query: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
E + +W++L+L + W + D+ L R +Q+ D + +LK +
Sbjct: 178 QAEEVNTEWEKLNLHSAD---WQRKIDETLER-------LQELQEATD-----ELDLKLR 222
Query: 1515 E-PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP-EERAQNVTRLLRK---------- 1562
+ VI + + V L + + LEK+ E+ P +E +V L R+
Sbjct: 223 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 282
Query: 1563 ----QAEEVNTEWEKLNLHSADWQRKIDE 1587
E++NT W+ L + D R++ E
Sbjct: 283 YNLSTLEDLNTRWKLLQVAVEDRVRQLHE 311
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 715 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 773
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 774 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 829
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 830 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 887
Score = 31.6 bits (70), Expect = 9.6
Identities = 42/234 (17%), Positives = 97/234 (41%), Gaps = 34/234 (14%)
Query: 372 VLKRLKAELNDIRPKVDSTRDQAANLMAN--------RGDHCRKLVEPQISELNHRFAAI 423
+L R + D++ ++++ D NL N G L++ ++ +N +++ +
Sbjct: 1 MLHRKTYHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 60
Query: 424 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD------------ 471
K S+ ++ + +SD K L E+ + LK+++ ++
Sbjct: 61 R------KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 114
Query: 472 MNEDNEGTVKELLQRGDNLQQRITDER---KREEIKIKQQLLQTKHNALKDLRSQR---- 524
N+ + +EL + + + R + ++ ++L Q + R+Q
Sbjct: 115 QNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRL 174
Query: 525 -RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQK 577
RK+A E++ +W + + D + +D+ ++L L E DE +K E+ K
Sbjct: 175 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIK 228
>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
Length = 1105
Score = 1888 bits (4891), Expect = 0.0
Identities = 947/975 (97%), Positives = 952/975 (97%), Gaps = 4/975 (0%)
Query: 1117 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1176
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 1177 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1236
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 1237 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 1297 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1356
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 1357 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1416
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 1417 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1476
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 1477 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1536
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 1597 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1656
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 1657 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1716
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 1717 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1776
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 1777 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1836
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 1837 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1896
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 1897 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1956
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 1957 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2016
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 2017 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTV-LEGDNMETPVTLINFWPVD 2075
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ + E D ++ P+
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQNLQAEYDRLKQQHEHKGLSPLP 960
Query: 2076 SAP---ASSPQLSHD 2087
S P +SPQ D
Sbjct: 961 SPPEMMPTSPQSPRD 975
Score = 332 bits (851), Expect = 3e-90
Identities = 167/168 (99%), Positives = 168/168 (100%)
Query: 2174 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2233
+NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 938 QNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 997
Query: 2234 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2293
ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 998 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 1057
Query: 2294 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1058 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 1105
Score = 100 bits (249), Expect = 2e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 719
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 720 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 777
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 778 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 827
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 828 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 887
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 888 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 940
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 941 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1000
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 1001 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1060
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 1061 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1117
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 1118 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1171
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 1172 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1231
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 1232 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1286
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 1287 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1337
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 73.6 bits (179), Expect = 2e-12
Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)
Query: 239 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 298
LT+WL+ D + + + G +++ + KAT +++E+++ L+ + + LK
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 299 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 356
+E T++ D++ + + W V + L E K + + + + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 357 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 410
L ES K+ P Q+K K+L +L + VD D A L+ + + V
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200
Query: 411 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 467
+N + +I R+ +A++ + L+QF D++K L L EAE V L++
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259
Query: 468 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 513
+ + ED++G VKEL+++ +LQ I DE ++ ++ + LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318
Query: 514 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 565
+ + S+ RKK+L I S QW + +LL L + +L+ P D
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+++ + + K EL E E L K ++E + R
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 685
N ++ +R++ V TE L + + + +I + L E+++ + DL + E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 686 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 740
+ + + ++ DSLQ ++ + + ++ + V L L+ L Q
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552
Query: 741 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 795
E +N +K Q + V + H D A Q T + WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604
Score = 52.4 bits (124), Expect = 5e-06
Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 47 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 93
K + D D +M + + DL LEE+ K +EA
Sbjct: 34 KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93
Query: 94 -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 151
+R+ +Q D Q+ LQ+ + + + + + +E++ +L + + L + +
Sbjct: 94 IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153
Query: 152 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 211
+ +Q ++ L K L + ++ V++ ++++ ++ +++ + + +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213
Query: 212 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 270
+V+ER+ LE+ +L ++ ++ WL T+ E T + E + G
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271
Query: 271 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 321
K K+ + + +++ T+V + L+++ G + L++ +L +N W +
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 373
++ + L + ++ + W+ D DE ++ P Q++ DV
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388
Query: 374 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 431
+ K EL P + ST + + + + KL EP+ R ++ ++
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445
Query: 432 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
K+ E+ N++ +KL NL D+ + ++E E ++EL + D L
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487
Query: 492 QRITDERKREEIK 504
++ R+ E IK
Sbjct: 488 LKL---RQAEVIK 497
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 1561 bits (4041), Expect = 0.0
Identities = 935/2388 (39%), Positives = 1401/2388 (58%), Gaps = 119/2388 (4%)
Query: 5 KLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDA 59
+L LS + A ++ +L E S + A +K L +QE +T ++++ +++++
Sbjct: 1105 QLEKLSKEIATQKSRLSE-SQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELES 1163
Query: 60 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKF 114
A +E ++ + D+ E+ ++ +K + + A Q + S+++V + Q + +
Sbjct: 1164 AV--EEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRI 1221
Query: 115 RLFQKPANFEQRLQ---ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 171
R K E+ E LD L LE + EV+ + + +SL V
Sbjct: 1222 R--GKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESV 1279
Query: 172 ----KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 227
+ + G+ ++ ++ + E++ A Y +L ++ LEK L+
Sbjct: 1280 LRHPADNRTQIRELGQTLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQ 1337
Query: 228 LSRKMRKEMNVLTEWLAATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
+ R+ + + VL E L D +LT R +P A A + +E+ + +
Sbjct: 1338 VLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
++S +T G + V + S + + + +L+ ++ ++
Sbjct: 1398 MRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAE 1457
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ + + D + Q D +L L++++ +V++ +++ +
Sbjct: 1458 LHVLDVKDVDPDVI---------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQT 1508
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNL 463
K ++ Q++ L + + ++ GK ++LE+ S + + ++ A + + ++
Sbjct: 1509 DNPKGMDEQLTSLKVLYNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSA 1562
Query: 464 KEEDF-NKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRS 522
E + K +E G + + N+ + + E+++ ++ + N ++
Sbjct: 1563 TETELVQKSTSEGLLGDLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEP 1620
Query: 523 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDR 573
++ ++ W + + +D L + + +L + E + EI++
Sbjct: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK 1680
Query: 574 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRL 625
+ K+EE+ V+R L D A + VE + Q S +E K A+ R
Sbjct: 1681 KPTSKQEEI--VKRLVSEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR- 1735
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKD 683
NF ++ + +++ ++ + T+ T + LE +E +L + +
Sbjct: 1736 NFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLES 1795
Query: 684 FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 743
++ K +E I++ LQ+ +++H E+++LQ L + K
Sbjct: 1796 SDEDEKMDEESAQIEEVLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIK 1847
Query: 744 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--- 800
+ + + G+ + + N+ L + +PE A Y+ +
Sbjct: 1848 AIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQ 1906
Query: 801 ---LKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 857
LK ++D + + + ++ ++I ++S +A +++ L LN +W + + SD
Sbjct: 1907 EDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSD 1966
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
RK + +F DLN+ W+ EA+ + PG L K ++ Q +L V +
Sbjct: 1967 RKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-I 2025
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 976
Q LN TG ++ +S + L+ KL N +W + + ++Q ++ +
Sbjct: 2026 SSHQPSFAALNRTGDGIVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE- 2082
Query: 977 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
K++ QL+ ++ WL+ + ++ + E ++QE Q + E
Sbjct: 2083 ------SKQVMKYRHQLDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAE 2134
Query: 1037 EI--LSKGQ-HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1093
++ L++ + + +K + P + K+ S + VN ++ + P +S
Sbjct: 2135 KLKWLNRTELEMLSDKSLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
Query: 1094 PTQTVTLVTQPVVTKETAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
+QT + P V K +S + + S E+ AD ++ TEL DWL L+DQ++K
Sbjct: 2192 VSQT-RIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLK 2250
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
S V VGD+E+IN+ + + K T DLEQR PQL+ + T AQNLKNK S+ + RT IT+++
Sbjct: 2251 SNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKL 2310
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
ER++NQWD Q ++ R+QQL +M+ DS QW + +EE E+++ + A+L ++ D
Sbjct: 2311 ERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--D 2368
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
+ K+I++ + L ++L V +++ KLL +Y +DDTR V TE + SW ++
Sbjct: 2369 PLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLK 2428
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
+ +++R+ ALE R +Q DLE FL W+ EAETT NVL DA+ +E L+DS +EL
Sbjct: 2429 QSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAREL 2488
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
+Q QD+Q EI+AH D++ ++D N QK++++L S++A +LQ RLD+MN +W++L+ KS
Sbjct: 2489 KQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSA 2548
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
+IR+HLEAS+++W RL +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D +A +RE
Sbjct: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEV 1567
LK KE +++ ++ R+FL +QP+E E + Q EL PEERAQ + + +RKQ+ EV
Sbjct: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
Query: 1568 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1627
+WE LN +++WQ+++D+ LE+L++LQ A D+LD +++AE ++ W+PVGDLLIDSL
Sbjct: 2669 KEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSL 2728
Query: 1628 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAV 1687
QDH+EK+ A R EIAP+ V VNDL+ QL+ L + S L+DLN RWKLLQV+V
Sbjct: 2729 QDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSV 2788
Query: 1688 EDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTEL 1747
+DR++QL EAHRDFGP+SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL
Sbjct: 2789 DDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTEL 2848
Query: 1748 YQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQII 1807
+QSLADLNNVRFSAYRTA+K+RRLQKALCLDLL LS + QH L QNDQ + + +I
Sbjct: 2849 FQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVI 2908
Query: 1808 NCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHL 1867
NCLTT YD LEQ H +LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K L
Sbjct: 2909 NCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLL 2968
Query: 1868 EDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFAN 1927
E+KYRYLFK+VA T CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ N
Sbjct: 2969 EEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNN 3028
Query: 1928 NKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKH 1987
NKPEI F+DWM LEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKH
Sbjct: 3029 NKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKH 3088
Query: 1988 FNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPR 2047
FNYD+CQSCFFSGR AKGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR
Sbjct: 3089 FNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPR 3148
Query: 2048 MGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSN 2107
+GYLPVQTVLEGDN+ETP+TLI+ WP P+ SPQL HDDTHSRIE YA+RLA+ME +N
Sbjct: 3149 LGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTN 3208
Query: 2108 GSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILA 2167
GS+L DS S S++DEH LIQ YCQ+L +SP+SQP+SPAQIL S+E EERGELERI+A
Sbjct: 3209 GSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIA 3268
Query: 2168 DLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGR 2227
DLEEE RNLQ EY++LK QH +GL P+ SPPE + + + D+ELIAEAKLLRQHKGR
Sbjct: 3269 DLEEEQRNLQVEYEQLKDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGR 3327
Query: 2228 LEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRV 2287
LEARMQILEDHNKQLESQLHRLRQLLEQP++++++NG SP S Q S S +
Sbjct: 3328 LEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDA 3384
Query: 2288 VGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 2335
G Q + G EDLL+PP DTST L EVMEQ++++FPS N P +P
Sbjct: 3385 SGPQFHQAAG-EDLLAPPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
Score = 137 bits (346), Expect = 9e-32
Identities = 333/1726 (19%), Positives = 656/1726 (38%), Gaps = 264/1726 (15%)
Query: 67 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQR 126
Q +Q + + LE K G + + + DV + + A E+
Sbjct: 887 QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA 946
Query: 127 LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 186
LQE K + + ++ PAL + E + ++ V +VE + K V
Sbjct: 947 LQEKKTLDEILENQKPALHKLAEETKALEKN-------------VHPDVEKLYKQEFDDV 993
Query: 187 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 246
Q K +N+L V++ LE+ R + V+ +W+
Sbjct: 994 QGK------------------WNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGV 1035
Query: 247 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETL 304
L K+ A +G + L ++ A EIE + LK++ E+ L++ V G K T
Sbjct: 1036 KDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIK-TW 1094
Query: 305 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT--LLDESE 362
V+ +L + ++ + L E Q+ +++ + +W+ QA+ L + E
Sbjct: 1095 VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154
Query: 363 KKKPQQKEDVLKRLKAELNDIRPK---VDSTRDQAANLMANRGDHCRKLVEPQISELN-- 417
K P++ E ++ +K D+ K V +D L A ++L SELN
Sbjct: 1155 YKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELT----SELNVV 1210
Query: 418 -HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDN 476
+ + +RI+ GK LE+ S +LL L+ E L+E + ++ +
Sbjct: 1211 LENYQLLCNRIR-GKC----HTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEK 1265
Query: 477 EGTVKELLQRGDNLQQRITDERKR-EEI-----------KIKQQLLQTKHNALKDLRSQR 524
V E L+ +++ + D R + E+ I + L+ ++ +DL
Sbjct: 1266 TDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLA 1325
Query: 525 RKKALEISHQWYQYKRQADDLLKCLD----DIEKKLASLPEPRDE-----RKIKEIDREL 575
K + + Q Q R+ D +L+ L +++K+L + R + ++ ++I E+
Sbjct: 1326 ESKQISLEKQ-LQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384
Query: 576 QKKKEELNAVRR--QAEGLSEDGAAMAVEPTQIQ-LSKRWREIESKFAQFRR-LNFAQIH 631
+ L +RR +++ L+ + A +Q+ L ++ RE+ +KF F++ NF
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF---- 1440
Query: 632 TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 691
E L+ V E+ HV L+V+ + PD+ + K
Sbjct: 1441 -----------EQRMLDCKRVLDGVKAEL-HV----LDVKDV--DPDVIQTHLDKCMKLY 1482
Query: 692 ESLKNIKDSLQQ--SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 749
++L +K ++ +GR I+ ++T + + E L+ L + +
Sbjct: 1483 KTLSEVKLEVETVIKTGR-HIVQKQQTDNPKG--------MDEQLTSLKVLYNDLGAQVT 1533
Query: 750 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE------NWEHAKYKWYLKE 803
+ + +R+ + R+ + ++WL+ E L + E + E + K LK+
Sbjct: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593
Query: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 863
L+ T+ + +A + +I+ S IL+E+L LN W V D L
Sbjct: 1594 LEKRKADLNTITES-SAALQNLIEGSE----PILEERLCVLNAGWSRVRTWTEDWCNTLM 1648
Query: 864 EQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 923
+N L F ++ WL +A+ + L+ +++ ++ E VK LV EL L
Sbjct: 1649 NHQNQLEIFDGNVAHISTWLYQAEAL----LDEIEKKPTSKQEEIVKRLVSELD--DANL 1702
Query: 924 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL----------PEKQGEIE 973
+ N +++ ++ +E KL + N + KVS+ + P Q +
Sbjct: 1703 QVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVT 1762
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1033
+ + G LE LE + ++L ++ E + + + + +
Sbjct: 1763 TETFETGVPFSDLEKLENDIENMLKFV---------------EKHLESSDEDEKMDEESA 1807
Query: 1034 DVEEILSKGQ---HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
+EE+L +G+ H E + ++ +L L + + + + + R K LA G+ +
Sbjct: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR-KMGQLASGIRS- 1865
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
PT + + + ++ + L +P L DF+ L + IK
Sbjct: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPE---LNTAIYEDFSFQEDSLKN--------IK 1914
Query: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
Q +G+ +I +K LE P+ ++ L K DRI
Sbjct: 1915 DQLDKLGE----QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAK----------WDRI 1960
Query: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
R+ + + +Q + L D TQW+ EAE++L A P
Sbjct: 1961 NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWI---TEAEELLVDTCA--------PGGSL 2009
Query: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
++K ++L + Q + N +++ S D + +N W +I
Sbjct: 2010 DLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIV 2069
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
V +R+ L+ + + ++ L++ + WLT+AE A +K E + ++EL
Sbjct: 2070 AEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAMQKRSTTELGENLQEL 2122
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR------LDNMNFKWSE 1444
+DL E+E H + L+ ++L SD ++ L R L +N W++
Sbjct: 2123 ----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERDKISESLRTVNMTWNK 2173
Query: 1445 LRKK------------------------------------SLNIRSHLEASSDQWKRLHL 1468
+ ++ + ++SH + L
Sbjct: 2174 ICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDK 2233
Query: 1469 SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIF 1528
++ EL WL L D L GD + K + K +L+ + P + +
Sbjct: 2234 TITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNL 2293
Query: 1529 LTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---NTEWEKLNLHSADWQR 1583
+ + E E + Q+ L ++Q E++ + +W+ + + R
Sbjct: 2294 KNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR 2353
Query: 1584 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1643
K + L LQ Q D L ++ +++ P GD ++ + + L+K+ G
Sbjct: 2354 KYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFDNVLQKLLEEYG---- 2406
Query: 1644 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 1689
++ +V + L T I L L W+ +Q + D
Sbjct: 2407 -SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRD 2451
Score = 133 bits (334), Expect = 2e-30
Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
+++ +L KK + + E L + A+ + K +E E + +
Sbjct: 231 EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
Query: 629 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 685
+ H + R ET +TE DM L+ +Y + V LL E D + D E
Sbjct: 291 EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
Query: 686 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 743
D F E+ + Q S G + + + + + E ++QE ++ L+ +WE
Sbjct: 345 VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
Query: 744 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 801
+ DRQ R + + ++ ++ + WLT E+ ++K + + K L
Sbjct: 404 LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K LQ + Q V +L + + S ++ +IL+++L L RW VC+ +R
Sbjct: 462 EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
Query: 860 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 917
RL+E + E + WL E+ + + + K+Q +L + ++ +L E++
Sbjct: 522 NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
Query: 918 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
+++ L QL+E G G +L ++ S K+ + ++ +W + + L + ++
Sbjct: 582 MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
Query: 975 QIKDLGQLEKKLEDL--------------------------------------------E 990
+ LG + +DL
Sbjct: 638 AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
Query: 991 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 1046
E LN +L W + I+ EI + ++++ A++ +Q P +E+ GQ L
Sbjct: 698 ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
Query: 1047 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 1099
KE T+ +K LE +SSEWK V++ L++L K Q D+ +
Sbjct: 757 EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
Query: 1100 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 1159
+ + + TKE + + S +P+L D ELT+ L L
Sbjct: 810 -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
Query: 1160 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 1219
P++E + L ++ S A + + ++
Sbjct: 852 --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
Query: 1220 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 1277
VQE +++R+Q L LK +LE + + VL + K + + ++K +
Sbjct: 889 VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
Query: 1278 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 1337
E K L + L + + + L ++ D + +++ W + VS
Sbjct: 949 EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
Query: 1338 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 1396
++ H LL++ L L F A T E + ++D K++ + D G++ + Q
Sbjct: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
Query: 1397 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 1456
EIE N+ E + LRS + +Q RL + + +L K+ +S L
Sbjct: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
Query: 1457 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 1515
S ++ L L E+ W+ Q +++ L R ++ RA K ++ KE
Sbjct: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
Query: 1516 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 1575
+ + +++ + P G E + L + N R EEV + W +L
Sbjct: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
Query: 1576 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 1624
LH D W ++E ++ + L E TD ++ L E + + + +G LI
Sbjct: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
Query: 1625 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 1661
D L D + EK++A E++SH+ + L +QL L
Sbjct: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
Score = 117 bits (294), Expect = 1e-25
Identities = 324/1651 (19%), Positives = 642/1651 (38%), Gaps = 298/1651 (18%)
Query: 127 LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS-------LSEVKSEVEMVI 179
L ++ L+EV L + E EQ+ + + + + + L+ +S V V+
Sbjct: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
Query: 180 KTGRQIVQKK--QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 237
+ G Q++ + E E+ E++T L + L + +R+ +L L +K K++
Sbjct: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQ 428
Query: 238 VLTEWLAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 295
L+ WL T+ + K ++ +L + K+ Q ++E ++V + S+T + +
Sbjct: 429 QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVD 488
Query: 296 TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 354
G+ T ++ED+L L W AV EE N L Q ++ + + +++
Sbjct: 489 ENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL-----------QEINILWQELLEE 537
Query: 355 DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 414
LL K +KE+ L +++ + +DQ ++S
Sbjct: 538 QCLL----KAWLTEKEEALNKVQTS---------NFKDQK-----------------ELS 567
Query: 415 ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
R A + ++ + + L +L + D+ +LL+ +A +K +N
Sbjct: 568 VSVRRLAILKEDMEMKRQT--LDQLSEIGQDVGQLLDNSKA-------------SKKINS 612
Query: 475 DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ 534
D+E EL QR D+L QR+ D + + + L KDL R + I+ +
Sbjct: 613 DSE----ELTQRWDSLVQRLEDSSNQVTQAVAK--LGMSQIPQKDLLETVRVREQAITKK 666
Query: 535 WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR-------R 587
K+ P P +R+I +D E +KK + ++A +
Sbjct: 667 ------------------SKQELPPPPPPKKRQI-HVDIEAKKKFDAISAELLNWILKWK 707
Query: 588 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM-- 645
A +E M ++ T ++ K+ + +E + Q R+ A +T ++ E M
Sbjct: 708 TAIQTTEIKEYMKMQDTS-EMKKKLKALEKE--QRERIPRAD---ELNQTGQILVEQMGK 761
Query: 646 ----PLEISYVPSTYLTEITHVSQAL------LEVEQLLNAPDLCAKDFEDLFKQEE--- 692
EI V +E +VSQ L +++++ +NA + E + K +E
Sbjct: 762 EGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWV 821
Query: 693 -----------SLKNIKDSLQQSSGRIDIIHSKKTAALQSAT-----PVERVKLQEALSQ 736
SL ++KDS Q+ + +H K A S + P +Q
Sbjct: 822 KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDS 881
Query: 737 LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY--DIKIFNQWLTEAEQFLRKTQIPENW-- 792
+++ V + +DRQ + ++ Y +K L ++E K Q+ N
Sbjct: 882 FLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSE---NKAQVSLNVLN 938
Query: 793 EHAKYKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQEKLGSLNLRWQ 849
+ AK + L+E + D I + Q A + ++++ D + +++ + +W
Sbjct: 939 DLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN 998
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQ 908
++ +S LEE L F+ D W++ D + G + L+ +L+Q
Sbjct: 999 KLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQ 1058
Query: 909 VKLLVEELPLRQGILKQLNE-----TGGPVLVSAPISPEEQDKL---ENKLKQTNLQWIK 960
V E+ + LK + E GPV A I Q +L + +L++ + +
Sbjct: 1059 CSAFVNEIETIESSLKNMKEIETNLRSGPV---AGIKTWVQTRLGDYQTQLEKLSKEIAT 1115
Query: 961 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ-LNHLLLWLSPIRNQLEIYNQPNQEGPF 1019
L E Q + KDL ++++ + EE+ L + SP +LE + +
Sbjct: 1116 QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSP--EELESAVEEMKRAKE 1173
Query: 1020 DVQETEIAVQAKQPDVEEILSK----GQHLYKE--------KPATQPVKRKLEDLSSEWK 1067
DV + E+ V+ + +++ + +K GQ L E + ++ K L W
Sbjct: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWS 1233
Query: 1068 AVNRLLQ------------ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI--- 1112
LL E R K ++ P T +++ V + T I
Sbjct: 1234 CWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL 1293
Query: 1113 ---------------SKLEMPSSLMLEVPALADFNRAWTE-LTDWLSLLDQVIKSQRVMV 1156
KLE +S ++ LA+ + E L DQ+++ + +
Sbjct: 1294 GQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
Query: 1157 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ-NLKNKTSNQEARTIIT--DRIERI 1213
G+L+ + + + Q +++ I+A + L+ N ++ + + R R
Sbjct: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
Query: 1214 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1273
+Q D +Q L+ + ++ + + + + ++VL +A+L D IQ
Sbjct: 1414 GSQMDVLQRKLREVSTKF-QLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQ 1472
Query: 1274 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1333
+ + +L K L + + V+ +++ D+ + + ++ + + +V
Sbjct: 1473 THLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV 1532
Query: 1334 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED-------SKG 1386
+E + LE +L ++ + WL+ ET ++Q +T E LL D +K
Sbjct: 1533 TEGKQDLERASQLARKMKKEAASLSEWLSATET--ELVQKST-SEGLLGDLDTEISWAKN 1589
Query: 1387 V-KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 1445
V K+L K+ DL + + E+S + +EGS+ +L+ RL +N WS +
Sbjct: 1590 VLKDLEKRKADL-----------NTITESSAALQNLIEGSEP--ILEERLCVLNAGWSRV 1636
Query: 1446 RKKSLNIRSHLEASSDQWKRLHLSLQELLVWL--------------QLKDDELSRQAPIG 1491
R + + + L +Q + ++ + WL K +E+ ++
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSE 1696
Query: 1492 GDFPAVQKQN-------------------------DVHRAFKR--------ELKTKEPVI 1518
D +Q +N +++R F++ +L + +
Sbjct: 1697 LDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPL 1756
Query: 1519 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 1578
L T F T P LEKL E +N+ + + K E + E EK++ S
Sbjct: 1757 YQCLVTTETFETGVPFSDLEKL---------ENDIENMLKFVEKHLES-SDEDEKMDEES 1806
Query: 1579 ADWQRKIDETLERLQEL--QEATDELDLKLR 1607
A +I+E L+R +E+ Q D K+R
Sbjct: 1807 A----QIEEVLQRGEEMLHQPMEDNKKEKIR 1833
Score = 112 bits (281), Expect = 3e-24
Identities = 294/1589 (18%), Positives = 628/1589 (39%), Gaps = 227/1589 (14%)
Query: 163 NLYKSLSEVKSEV-EMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 220
+L + L + ++V + V K G QI QK E + ++ +T K EL +K+
Sbjct: 623 SLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKR 680
Query: 221 QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEK 279
Q+ ++ +K L W+ + E M SE+ KA +KE +
Sbjct: 681 QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRE 740
Query: 280 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---NSNWIAVTSRAEEWLNLLLEYQKH 336
+ + + G+ L +GK+ E+ ++L +S W V+ E+ L ++ Q+
Sbjct: 741 RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQED 799
Query: 337 METFDQNVDHITKWIIQAD-----TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTR 391
+ + + +D + K I + T + ES ++ +D +R L + PK++ R
Sbjct: 800 INAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMAR 859
Query: 392 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-------PLKELEQFNS 444
+ LM+ V+ R+ A+ ++ + + P +
Sbjct: 860 ASCSALMSQPS--APDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917
Query: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 504
++ +L E + Q +N+ + + + T+ E+L+ ++ +E K E
Sbjct: 918 TLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKN 977
Query: 505 I--------KQQL--LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 554
+ KQ+ +Q K N LK L S+ EI+ ++ + + K +D ++
Sbjct: 978 VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKD 1037
Query: 555 KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS----- 609
L + + D LQ++ ++ +A + E + M T ++
Sbjct: 1038 FLMKQQAAQGD------DAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091
Query: 610 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT-EITHVSQALL 668
K W ++++ ++ Q+ + +E + T+ L S + L ++ + + +
Sbjct: 1092 KTW--VQTRLGDYQ----TQLEKLSKE---IATQKSRLSESQEKAANLKKDLAEMQEWMT 1142
Query: 669 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 728
+ E+ D K E+L E +K K+ + Q R+ I+ L + P
Sbjct: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN-IKLLAAKVPSGG- 1200
Query: 729 KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW----RRFHYDIKIFNQWLTEAEQFLR 784
QE S+L+ E + +G+ E W HY + + WL E+ ++
Sbjct: 1201 --QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY-LDLETTWLNTLEERMK 1257
Query: 785 KTQI-PENWEHAKYKWYLKELQDGI---GQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
T++ PE + L+ L+ + +T +R L G+ +I D I+ EK
Sbjct: 1258 STEVLPEKTDAVNEA--LESLESVLRHPADNRTQIREL---GQTLIDGGILDD--IISEK 1310
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE----- 895
L + N R++++ ++ LE+Q +L E + L L E D + L
Sbjct: 1311 LEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDA 1370
Query: 896 ---PGKEQQLKEKLEQVKLLVEEL-------PL--------RQG-----ILKQLNETGGP 932
P + Q+++ ++ +L +EEL PL R G + ++L E
Sbjct: 1371 FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTK 1430
Query: 933 VLVSAPISPEEQDKLENK---------------------LKQTNL-QWIKVSRALPEKQG 970
+ + EQ L+ K + QT+L + +K+ + L E +
Sbjct: 1431 FQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKL 1490
Query: 971 EIEAQIKDLGQLEKKLE-----DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE-T 1024
E+E IK + +K + ++EQL L + + + Q+ EG D++ +
Sbjct: 1491 EVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV-------TEGKQDLERAS 1543
Query: 1025 EIAVQAKQ--PDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1082
++A + K+ + E LS + +K ++ + L DL +E +L++L ++ D
Sbjct: 1544 QLARKMKKEAASLSEWLSATETELVQKSTSEGL---LGDLDTEISWAKNVLKDLEKRKAD 1600
Query: 1083 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1142
L T ++ Q + ++P++ + + A ++R T DW
Sbjct: 1601 L--NTITESSAALQNLIEGSEPILEERLCVLN--------------AGWSRVRTWTEDWC 1644
Query: 1143 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELIT------------AA 1190
+ L + G++ I+ + + +A + ++E++ +E I
Sbjct: 1645 NTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQV 1704
Query: 1191 QNLKNK------TSNQEARTIITDRIERIQNQWDEVQEHLQNRR----QQLNEMLKDSTQ 1240
+N++++ +R ++ ++ + +++V +H+++ + Q+ +T+
Sbjct: 1705 ENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTE 1764
Query: 1241 WLEA----------KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1290
E + + E +L LES E +D +I E Q +++
Sbjct: 1765 TFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVLQRGEEMLHQP 1823
Query: 1291 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1350
+ + L+LL ++ + K I + R + + S ++L T L++
Sbjct: 1824 MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSLLPTDYLVE-- 1875
Query: 1351 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1410
+ K L + + E + NV + T + ED ++ +K +D ++ V H
Sbjct: 1876 ---INKILLCMDDVELSLNVPELNT---AIYEDFSFQEDSLKNIKDQLDKLGEQIAVIH- 1928
Query: 1411 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1470
E ++ G +A+ ++ L +N KW + + + + + + ++W++ H L
Sbjct: 1929 --EKQPDVILEASG-PEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDL 1985
Query: 1471 QELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRELKTKEPVIMS 1520
+L W+ ++ L GG Q++ +V +F +T + ++
Sbjct: 1986 NDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQK 2045
Query: 1521 TLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAEEVNTEWEKLN 1575
+ FL E+ L GL + + E ++ P + ++ + R Q +E+ W
Sbjct: 2046 LSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIIC-WLTKA 2103
Query: 1576 LHSADWQRKIDETLERLQELQEATDELDL 1604
H+ +R E E LQEL++ T E+++
Sbjct: 2104 EHAMQ-KRSTTELGENLQELRDLTQEMEV 2131
Score = 70.9 bits (172), Expect = 1e-11
Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)
Query: 1334 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1393
+E + + E L + + LE+ L WL AE T D + +D + VK+
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
Query: 1394 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
+ E+ AH + V L +Q I + ++ +Q ++ +N +W LR +S++
Sbjct: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 1510
+S L + ++ L Q+L WL L ++ + + P+ D ++QK + H++ + +
Sbjct: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
L+ ++ + S V I E ++ T +L Q +++
Sbjct: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
W + + + ++ E QEL E L L + E + + + + +D
Sbjct: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 1681
E ++R +A LKE++ QL+ +G + S S E+L RW
Sbjct: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
Query: 1682 LLQVAVEDRVRQLHEAHRDFG 1702
L +ED Q+ +A G
Sbjct: 623 SLVQRLEDSSNQVTQAVAKLG 643
Score = 35.4 bits (80), Expect = 0.66
Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)
Query: 2154 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 2213
++ ++ E+++ L LE+E R D L Q + + E +PT +
Sbjct: 719 MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775
Query: 2214 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 2273
+ +E K + QH LE ++Q+ ED N + QL L ++++ + K + SS +
Sbjct: 776 VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834
Query: 2274 LQRSDSSQPMLLRVVG 2289
DS Q L ++G
Sbjct: 835 PSLKDSCQRELTNLLG 850
Score = 34.3 bits (77), Expect = 1.5
Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)
Query: 1510 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 1567
+L K+ +IM + + ++ + ++ PR+ E E A N+ Q+
Sbjct: 236 QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
Query: 1568 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1627
E E + ++D L+ Q A +E+ L AE + D ++ +
Sbjct: 290 EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
Query: 1628 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 1684
+D +A E+ + +V V QL T G E LN RW+ L+
Sbjct: 346 KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
Query: 1685 VAVEDRVRQLHE 1696
V DR +LH+
Sbjct: 406 VESMDRQSRLHD 417
>gi|5032297 dystrophin Dp71 isoform [Homo sapiens]
Length = 617
Score = 1240 bits (3208), Expect = 0.0
Identities = 610/610 (100%), Positives = 610/610 (100%)
Query: 1732 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1791
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 1792 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1851
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 1852 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1911
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 1912 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1971
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 1972 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2031
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 2032 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2091
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367
Query: 2092 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2151
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427
Query: 2152 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2211
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487
Query: 2212 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2271
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547
Query: 2272 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 2331
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 548 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 607
Query: 2332 PGKPMREDTM 2341
PGKPMREDTM
Sbjct: 608 PGKPMREDTM 617
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 376 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 435 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 491 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548
>gi|5032299 dystrophin Dp71b isoform [Homo sapiens]
Length = 635
Score = 1214 bits (3142), Expect = 0.0
Identities = 598/599 (99%), Positives = 598/599 (99%)
Query: 1732 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1791
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 1792 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1851
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 1852 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1911
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 1912 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1971
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 1972 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2031
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 2032 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2091
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367
Query: 2092 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2151
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427
Query: 2152 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2211
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487
Query: 2212 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2271
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547
Query: 2272 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2330
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 548 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 606
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 376 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 435 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 491 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548
>gi|5032301 dystrophin Dp71a isoform [Homo sapiens]
Length = 604
Score = 1203 bits (3112), Expect = 0.0
Identities = 597/610 (97%), Positives = 597/610 (97%), Gaps = 13/610 (2%)
Query: 1732 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1791
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 1792 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1851
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 1852 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1911
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 1912 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1971
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 1972 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2031
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 2032 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2091
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET PASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354
Query: 2092 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2151
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414
Query: 2152 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2211
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474
Query: 2212 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2271
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534
Query: 2272 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 2331
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 535 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 594
Query: 2332 PGKPMREDTM 2341
PGKPMREDTM
Sbjct: 595 PGKPMREDTM 604
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 363 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 422 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 478 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535
>gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]
Length = 622
Score = 1177 bits (3046), Expect = 0.0
Identities = 585/599 (97%), Positives = 585/599 (97%), Gaps = 13/599 (2%)
Query: 1732 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1791
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 1792 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1851
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 1852 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1911
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 1912 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1971
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 1972 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2031
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 2032 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2091
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET PASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354
Query: 2092 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2151
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414
Query: 2152 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2211
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474
Query: 2212 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2271
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534
Query: 2272 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2330
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 535 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 593
Score = 35.0 bits (79), Expect = 0.86
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 923 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 978
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 363 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421
Query: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1038
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 422 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477
Query: 1039 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1095
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 478 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535
>gi|148539558 dystrophin related protein 2 [Homo sapiens]
Length = 957
Score = 996 bits (2574), Expect = 0.0
Identities = 494/892 (55%), Positives = 651/892 (72%), Gaps = 27/892 (3%)
Query: 1438 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1497
MN W+E++KKS N+R+ LEA SD +L L LQE++ WL KD+ELS Q P+ GD V
Sbjct: 79 MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALV 138
Query: 1498 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1557
Q++ + H AF E+K++ P I S LE+ + FL++ P E LE+ + E ++ P++R QN++
Sbjct: 139 QQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLS 198
Query: 1558 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1617
R + KQA + WEKL D R I+ TLE+L E+Q A +EL L QAE ++ +W+
Sbjct: 199 RFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWE 258
Query: 1618 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 1677
P+GDL IDSL +H++ +K + E +P+K+ V VNDLA QL + LS N LE +N
Sbjct: 259 PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQIN 318
Query: 1678 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 1737
RWK LQ +V +R++QL +AHRDFGP SQHFLS+SVQ PWERAISPNKVPYYINH+ QTT
Sbjct: 319 VRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTT 378
Query: 1738 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 1797
CWDHPKMTELYQ+LADLNN++FSAYRTAMKLRR+QKAL LDL++L+ A + ++H+L+ +
Sbjct: 379 CWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQAS 438
Query: 1798 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 1857
+ MD++++I+CLT +Y+RLE+E LVNVPLCVDM LNWLLNV+D+GR+G++R LSFKT
Sbjct: 439 EHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKT 498
Query: 1858 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 1917
GI LC +++K +YLF QVA+S CDQR LG+LLH++IQ+PRQLGEVA+FGGSN+EP
Sbjct: 499 GIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEP 558
Query: 1918 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 1977
SVRSCF+F+ KP IEA+ FL+W+ LEPQSMVWL VLHRV AE KHQ KC+IC++CPI
Sbjct: 559 SVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPI 618
Query: 1978 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 2037
GFRYRSLK FN DICQ+CF +GR +KG+K+HYP++EY TPTTS E++RDFA LKNKFR
Sbjct: 619 KGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFR 678
Query: 2038 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 2097
+K YF+KHP+ GYLPVQ+VLE D ET PASSP H DTHSRIEH+A
Sbjct: 679 SKHYFSKHPQRGYLPVQSVLEADYSET-------------PASSPMWPHADTHSRIEHFA 725
Query: 2098 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLS--QPRSPAQILISLE 2155
SRLAEME+ N S+ NDS+SP++SID++ L++H SP++ +P Q S+
Sbjct: 726 SRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRH-------SSPITDREPAFGQQAPCSVA 778
Query: 2156 SEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELI 2215
+E +GEL++ILA LE+ENR LQ E RLK QHE + PS + + R+ EL+
Sbjct: 779 TESKGELQKILAHLEDENRILQGELRRLKWQHEE--AAEAPSLADGSTEAATDHRNEELL 836
Query: 2216 AEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQ 2275
AEA++LRQHK RLE RMQILEDHNKQLESQL RLR+LL QP E+ +G+ SS ++S Q
Sbjct: 837 AEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQ 896
Query: 2276 RSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 2327
+S+ S P R G T D+ +D+ S QD S LE++ME+L ++FPS R
Sbjct: 897 QSEGSHP---REKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVR 945
Score = 65.9 bits (159), Expect = 5e-10
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 33/235 (14%)
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
E+ DWLS D+ + +Q + GD+ + + A M++++ R P + ++ +AQ ++
Sbjct: 113 EIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQ 172
Query: 1197 TSNQE-----ARTIITDRIERIQN--------------QWDEVQEHLQNRRQQLNEMLKD 1237
+E + + T +RIQN W+++ ++ + + L+
Sbjct: 173 HPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQ 232
Query: 1238 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1296
+ A EE L QA +W+ G +D++ + I K ++ + V +
Sbjct: 233 LLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLV 292
Query: 1297 NDLALKLLRDYSADDTRKVHMITEN------INASWRSIHKRVSEREAALEETHR 1345
NDLA +L VH+ EN IN W+ + VSER L++ HR
Sbjct: 293 NDLAHQLA-------ISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHR 340
Score = 43.5 bits (101), Expect = 0.002
Identities = 72/339 (21%), Positives = 132/339 (38%), Gaps = 51/339 (15%)
Query: 843 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQ 900
++NL W E+ K+ + + RLE + + Q L E + WL + D A +PL+ G
Sbjct: 78 AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQ-GDVA 136
Query: 901 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK---------- 950
++++ E +EE+ R + + E+ L P E+ E+K
Sbjct: 137 LVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQN 196
Query: 951 -----LKQTNLQ---WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL----LL 998
KQ + W K++ ++ IE ++ L +++ +E+L L+
Sbjct: 197 LSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRAT 256
Query: 999 WLSPIRNQLEIYNQPNQEGPFDVQETEIA-----VQAKQPDVEEILSKGQHLYKEKPATQ 1053
W PI L I + P + + E + V+ ++ HL E
Sbjct: 257 W-EPI-GDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN---- 310
Query: 1054 PVKRKLEDLSSEWK----AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 1109
+ LE ++ WK +V+ L++L+ D PG +S Q V E
Sbjct: 311 --SQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQ---------VPWE 359
Query: 1110 TAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
AIS ++P + + + TEL L+ L+ +
Sbjct: 360 RAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNI 398
Score = 37.0 bits (84), Expect = 0.23
Identities = 35/174 (20%), Positives = 77/174 (44%), Gaps = 14/174 (8%)
Query: 203 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
A+ L +NE+ K + +LE S K++ + + +WL+ D EL+ + ++G +
Sbjct: 78 AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVAL 137
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEAL----------KTVLGKKETLVEDKL-SL 311
+ E A +E++ + ++ S+ E +A + K+T + ++ +L
Sbjct: 138 VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197
Query: 312 LNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLLDESE 362
W T +E W L ++ +H+E + + I + + T L ++E
Sbjct: 198 SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAE 251
Score = 32.7 bits (73), Expect = 4.3
Identities = 33/163 (20%), Positives = 73/163 (44%), Gaps = 21/163 (12%)
Query: 713 SKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIF 772
SK T+ Q + R ++A + WEK+ D+ +R++E+ ++
Sbjct: 185 SKDTSPKQRIQNLSRFVWKQATVASEL-WEKLTARCVDQHRHIERTLEQLLEIQGAMEEL 243
Query: 773 NQWLTEAEQFLRKT----------QIPENWEHAK-YKWYLKELQDGIGQRQTVVRTLNAT 821
+ L++AE +R T +PE+ + K +K ++DG+ + L +
Sbjct: 244 STTLSQAEG-VRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAIS 302
Query: 822 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 864
+ ++S+ L +N+RW+++ +S+R K+L++
Sbjct: 303 DVHLSMENSQA--------LEQINVRWKQLQASVSERLKQLQD 337
>gi|5032305 dystrophin Dp40 isoform [Homo sapiens]
Length = 340
Score = 693 bits (1789), Expect = 0.0
Identities = 333/333 (100%), Positives = 333/333 (100%)
Query: 1732 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1791
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 1792 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1851
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 1852 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1911
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 1912 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1971
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 1972 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2031
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 2032 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 2064
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 340
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 249 bits (635), Expect = 3e-65
Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)
Query: 16 RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 68
R+ K L + +A+E E ++ + I++QLA + ++VD QM +
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
Query: 69 --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 119
IQS D+ E +EE+ + K+ AQR+ +LQ+ +
Sbjct: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3781
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 179
F+ L+ L + + + + S E +VV++Q+ L + L + K+ V+M+
Sbjct: 3782 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
Query: 180 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 239
G +I Q + + +++ ++ +L+ + EL +K R++QLE L L+++ + +
Sbjct: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900
Query: 240 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 299
+++L+ T+ +L V + + ++ KA +++IE + ++G++L ++
Sbjct: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
Query: 300 KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 358
E ++ +K+ L + + + R LL + + F ++ + W+ + + L
Sbjct: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
Query: 359 DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 411
K K+DVL R L E+ + + VD L+ L++
Sbjct: 4021 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 4078
Query: 412 QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 471
++ + R+A I+ + + KA L++ Q + Q E L +++ ++EE
Sbjct: 4079 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 4133
Query: 472 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 530
+ + QR L++ + + R + + AL +L R ++ L+
Sbjct: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 4187
Query: 531 -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 583
+S QYK +D + + +D+I+ + R ++ + D EL ++K L
Sbjct: 4188 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 4242
Query: 584 AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 638
+R + + + A + V+ I + + ++ F+ F Q ++E+T
Sbjct: 4243 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299
Query: 639 MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
++ + + + + + + +S + E L+ A D E
Sbjct: 4300 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 4359
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E ++ +++S+ + ID + K L+ P E ++E + + + ++ +
Sbjct: 4360 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
Query: 747 MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 802
+ R D +V + + FH I+ + L LR IP E K + +
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 4476
Query: 803 ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 855
+ + + + Q L GEE+I +S D + +Q+KL + W+++ +
Sbjct: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536
Query: 856 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 914
+R+ + + + +F D+ + +++ +I PG + + K+++E + + E
Sbjct: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
E L+ + G ++ + E+ ++ + + N W +++ E+ ++E
Sbjct: 4597 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ + + L++ ++ L P+ L E ++E ++ V +
Sbjct: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4710
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E++ +G+ + K+ AT R + + L EL+ +L
Sbjct: 4711 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4752
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ A + ++ +L+ AL F A EL WL+ ++++ +
Sbjct: 4753 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4792
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
QR + GD + I + K D+ + +E + A L ++ +A + + R+E
Sbjct: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4851
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ W+ V + + R QQL L+ + + E+ L + ++L + K +
Sbjct: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4911
Query: 1272 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
++++ +L L+ + +T + + L LL + K + W +
Sbjct: 4912 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4971
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
++ ER++ LEE L +F L++F+ WLT AE + N+ A+ +L V
Sbjct: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 5025
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
+++ + E+ AH D LD+ + L+ L D VL++ L ++ +W ++ ++S+
Sbjct: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 5084
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
L+ + + K+ H + ++L+ WL+ + L + I D ++ Q H+ F++
Sbjct: 5085 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 5144
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
L K+PV +T+ T R + + L PE+ +Q + L EV +
Sbjct: 5145 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 5185
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1629
W+ + S + Q K++E L + +A L L + E QPV GDL D + +
Sbjct: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 5243
Query: 1630 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1686
++ K + E+ V + R+L + + L++L+TRW L V+
Sbjct: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303
Query: 1687 VEDRVRQ 1693
+ R+ Q
Sbjct: 5304 KQSRLEQ 5310
Score = 218 bits (555), Expect = 6e-56
Identities = 322/1681 (19%), Positives = 689/1681 (40%), Gaps = 194/1681 (11%)
Query: 13 KAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI-- 69
+ R+ LL+Q++ +A+ E + ++ DK + ++ D Q A +
Sbjct: 3984 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 4043
Query: 70 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------- 114
++ + + ++++ K+ Q Q ++ + Q+KL + ++
Sbjct: 4044 NEEIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 4102
Query: 115 RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
+ Q F+ +E L EV+ L +S E + L K + E +
Sbjct: 4103 QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV 4162
Query: 175 VEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
++ V + R +++ + LD+ V+ Y + + +R +++ ++ S++ +
Sbjct: 4163 LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV 290
+ W+A T +L + +++ KA +I + K + + +E+
Sbjct: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282
Query: 291 ----GEALKTVLGKK-ETLVE--DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
GE KTVL +K E+L++ + +SLLNS A RA+ +N E + + +
Sbjct: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW--- 4339
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMAN 400
++ I Q + + E+ + QQ+E +++L+ + + +P +D Q L
Sbjct: 4340 IEETRALIAQLPSPAIDHEQLRQQQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPE 4397
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEA 455
G+ +VE + + + +A I ++ +A ++ +F+ I+ +LE LE
Sbjct: 4398 EGE----MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE- 4452
Query: 456 EIQQGVNLK-----EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 510
+ + + E D ++ DN+ EL + LQ ++R E +L+
Sbjct: 4453 NLSSRLRMPPLIPAEVDKIRECISDNKSATVEL----EKLQPSFEALKRRGE-----ELI 4503
Query: 511 QTKHNALKDLRSQRRKKALE-ISHQWYQYKRQADDL-LKCLD----------DIEKKLAS 558
A KDL ++ + L+ + W K +A++ +K LD D+ L +
Sbjct: 4504 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4563
Query: 559 LPEPRD---ERKIKEIDRELQKKK-EELNAVRRQAEGLSED-------GAAMAVEPTQIQ 607
+ + +D + + ID + K++ E ++ + +GL E+ GA + + +
Sbjct: 4564 IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETE 4623
Query: 608 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 667
+ + I+ + LN +E + + + M + Y + QA+
Sbjct: 4624 KPEVRKSIDEMNNAWENLN-----KTWKERLEKLEDAMQAAVQYQDTL---------QAM 4669
Query: 668 LE-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 722
+ V +L P + D + Q +K K + Q ++ ++ + L+ A
Sbjct: 4670 FDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4728
Query: 723 TP-VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQ 781
T +R ++E L++L WE + + RQ + + ++ +F + ++ WLT E+
Sbjct: 4729 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4788
Query: 782 FLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 838
L Q P + + + L + L++ + Q V T+N G E+++ S+ DAS L+
Sbjct: 4789 LL-DAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR 4847
Query: 839 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPG 897
+L ++N W+ V ++ +R+++L+ F ++ +F+L L ++ +++ G
Sbjct: 4848 SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGG 4907
Query: 898 KEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 957
+ +E+L+ L +L ++ QL + G +L+S S K E + +
Sbjct: 4908 LPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS-GSGSKTEQSVALLEQK 4966
Query: 958 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN--- 1014
W VS + E++ ++E + + + L++ + WL+ L I + P+
Sbjct: 4967 WHVVSSKMEERKSKLEEALNLATEFQNSLQE-------FINWLTLAEQSLNIASPPSLIL 5019
Query: 1015 QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEWKAV 1069
++E ++ V A + + E+ G L +K +K L + S W+ V
Sbjct: 5020 NTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKV 5079
Query: 1070 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 1129
+ +E SL
Sbjct: 5080 VQ-----------------------------------------RSIERGRSLDDARKRAK 5098
Query: 1130 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 1189
F+ AW +L DWL + + S+ + D + I + K K + L ++P + I
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRT 5158
Query: 1190 AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 1249
+ LK KT E + + + ++++WD V R+ +L E L S Q+++A +
Sbjct: 5159 GRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALV 5218
Query: 1250 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 1309
L + +L + +D + + K K+L + V V +L+ + S
Sbjct: 5219 DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SR 5277
Query: 1310 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT-- 1367
DDT V + ++ W ++ K +++ LE+ + + F + L WL+EAE T
Sbjct: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
L D T + L D+ KE MK+ ++ + ++ + + +++ ++ D
Sbjct: 5338 FRGALPDDTEALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPD 5387
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 1486
++ + + ++ E+ + + LE + + L+ELL W+Q + L +
Sbjct: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 5447
Query: 1487 --QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEG 1536
Q PI + V+ H+ F E+ K+P + +E E+ G
Sbjct: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSG 5507
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
K +P PP + + + +++ W+++ L + + QRK+++ L+RL+EL+
Sbjct: 5508 GRKSLSQP--TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELK 5565
Query: 1597 E 1597
E
Sbjct: 5566 E 5566
Score = 211 bits (538), Expect = 5e-54
Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)
Query: 96 VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 155
+LS+ QK+L+D+ + + F + A + L + L E + +Q
Sbjct: 3872 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3925
Query: 156 SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 215
Q+ L + + ++V +K G+ + L E++ +L+ Y+E+ +
Sbjct: 3926 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985
Query: 216 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 275
+ L++ L +R ++ + WLA + +L+ + L + A A +
Sbjct: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045
Query: 276 EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 334
EI +K ++ + G+AL K G++ L+++KL + + + +T + + L L + +
Sbjct: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105
Query: 335 KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 389
+ F + +T W+ + + L S + P Q + K LK E+ + R +D+
Sbjct: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
Query: 390 TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 443
+ + L+ R+ ++ +S+ N ++ +S I + + ++ +Q+ +
Sbjct: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225
Query: 444 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 496
+++ + E + G E+D + + ++++ D++ + +
Sbjct: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
Query: 497 --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 554
E ++ ++ K + L ++ A+ L S+R + Q+ ++L +++
Sbjct: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
Query: 555 KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 611
+A LP P D ++++ E+++ +E + + + L + G + + P + ++ ++
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
Query: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 671
+++ E+ +AQ ++EE V + L+ + ST +TE + +LE
Sbjct: 4406 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
Query: 672 QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+ L++ P L + + + + K+ L++ + + + + + ++
Sbjct: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
Query: 728 ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 783
++Q+ L Q+ F WE + ++R+ +F +E +F YD+ + + + +
Sbjct: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
Query: 784 RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 835
+ P + E A+ +KE DG+ + +R L G ++I +T+
Sbjct: 4572 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4625
Query: 836 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 894
+++ + +N W+ + K +R ++LE+ ++Q L WL+ + ++P
Sbjct: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
Query: 895 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 954
+K++L ++K E+ +Q +++LN G +L A ++D + L +
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4744
Query: 955 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1014
W + + +Q ++E + LGQ + LE+L + WL+ L+ Q
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4795
Query: 1015 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1064
G V E E+A V A Q VE + G L + ++ +LE ++
Sbjct: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
Query: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
W++V LQ+ ++ L L ++ ++ + M S L
Sbjct: 4856 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4902
Query: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
P A +L + L Q+ + E N+++ K + +
Sbjct: 4903 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4944
Query: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
L S ++T + ++ +W V ++ R+ +L E L +T++ +
Sbjct: 4945 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994
Query: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
+E L A L ++ + +I E K A ++ + + + +L
Sbjct: 4995 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 5054
Query: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
D + + ++ + W + +R ER +L++ + +QF +K + WL +A
Sbjct: 5055 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 5114
Query: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1424
E+ + + + D +K + + ++ Q + VY + +
Sbjct: 5115 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 5168
Query: 1425 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1484
+D+ L L + KW + KS+ + LE + + +LQ L+ WL + +L
Sbjct: 5169 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 5228
Query: 1485 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+ P+ GD V D H+ F++EL + + + L +
Sbjct: 5229 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 5269
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
REL E +++ T ++ Q +E++T W+ + S Q ++++ L++ + ++ L
Sbjct: 5270 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
Query: 1605 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1641
L +AE + D LID+ ++ ++KV+ R ++
Sbjct: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
Score = 209 bits (531), Expect = 3e-53
Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 78
LE+ Q +E ++S I++ + QL + + + + + ++ + Q L + E
Sbjct: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
Query: 79 SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 123
++ ++ QG A ++L Q +VAQ++ +V + + F
Sbjct: 3505 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
Query: 124 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 183
R++E L ++ L + + + +QSQ+ + +K ++E R
Sbjct: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3624
Query: 184 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 243
+++++ T + L + AL +L + R++QLE L +++ L +
Sbjct: 3625 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
Query: 244 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 302
A + + V ++ ++A K QKE ++ ++ L+ + +G+ L GK
Sbjct: 3685 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3744
Query: 303 TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 360
+ +E + +N+ W + + + + L E H F ++ + W+ + L+
Sbjct: 3745 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3802
Query: 361 SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 413
+ +K P + V+K L+ L+D + VD + + + + R+ + Q+
Sbjct: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3862
Query: 414 SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 453
L R+ + KA+ K+LE F S +K L EP+
Sbjct: 3863 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
Query: 454 ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 510
A+IQQ + ++ + +D+ E++ V + ++ G +L +T ++ + K L
Sbjct: 3918 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3974
Query: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
Q +++ ++D ++ + + ++L L ++E KL+S+ +K+
Sbjct: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 4027
Query: 571 IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 622
+++ ++ EE+ ++ + ++G A+ + T ++ +++
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 4083
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+ +A I + + + + L + STY ++ L EVE+ L +
Sbjct: 4084 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 4137
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
E + + ++ K +K + + +D ++ A L+ R L + +S + Q++
Sbjct: 4138 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 799
V+ R D ++++ +++ W+ E ++ L ++ ++ A+ +
Sbjct: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 4256
Query: 800 YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K I + + + L + EI + ++LQEK SL +++ + S+R
Sbjct: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
RLE + ++++F E W+EE IA +P +QL+++ E+++ L E +
Sbjct: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376
Query: 919 RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 975
+ + +L + G + ++PEE + +E K ++ + ++ + ++ E +Q
Sbjct: 4377 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433
Query: 976 IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1029
+ + K+E + E L +L L + P+ +++ N+ ++++ + + +
Sbjct: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493
Query: 1030 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1079
A + EE++ + Q K+ A + ++ KL+ + W+ + +E K
Sbjct: 4494 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4552
Query: 1080 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1111
D+A LTTI SP +++ Q V ET
Sbjct: 4553 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4612
Query: 1112 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1141
K E+ S+ A + N+ W E + DW
Sbjct: 4613 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
L + + + DL + + + + K ++ Q++ ++E+L + + K +++
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1261
R II + + +++ W+ + E + +R+ +L L Q+ A EE L L++
Sbjct: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
Query: 1262 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1321
+ I+ ++ + L D+ Q V+ N +LL + DD + E
Sbjct: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4852
Query: 1322 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1381
+N W S+ ++ ERE L+ T + Q F ++E FL LT E+ + A++ L
Sbjct: 4853 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4908
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
++ +E + +L +++A + Y+ L + + +L S + S ++ + + K
Sbjct: 4909 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4966
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1501
W + K +S LE + + SLQE + WL L + L+ +P V Q
Sbjct: 4967 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 5026
Query: 1502 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1561
+ H+ F E+ I+ +L Q +L + Q+V L++
Sbjct: 5027 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 5066
Query: 1562 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1620
V + WEK+ S + R +D+ +R ++ EA +L L AE S +
Sbjct: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
Query: 1621 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1678
D + L H E K L G+ P+ + ++ T L + + L ++
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 5184
Query: 1679 RWKLLQVAVEDRVRQLHEA 1697
+W + +R +L EA
Sbjct: 5185 KWDTVCGKSVERQHKLEEA 5203
Score = 155 bits (393), Expect = 3e-37
Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)
Query: 145 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 202
+T + + V+Q QL L + L+E + VE + K R I++ + P + + E
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
Query: 203 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
++ H+ L + ER L+K + S+ +++ + L + + + L +
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 313
+ +A +++I +QK L++ E V ++T +++ KL+ ++
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2642
Query: 314 ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 357
S+ + +AE + +L + Q+ ME DQ++ H + I + +
Sbjct: 2643 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2701
Query: 358 LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 410
E + Q+ D L+ L EL+ +D +D+ NL + + + + E
Sbjct: 2702 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
Query: 411 ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 457
Q+ E +K + SIP E +++K +E L++ +
Sbjct: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2817
Query: 458 QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 510
+ +N K + E D++G +L + + + EI+ +
Sbjct: 2818 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2877
Query: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
K+ L + +R++ I ++ + ++A+ +L+ L+ E+ L S+ K +
Sbjct: 2878 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2937
Query: 571 IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 626
+ + + K EL + + + E A + V Q ++ W++I+ + +++ R
Sbjct: 2938 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2997
Query: 627 FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 679
+ R EE+ + E P E+ L ++ +LNA
Sbjct: 2998 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057
Query: 680 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 739
K+FE +Q E L + G + + S+ LQS + V+L + L+
Sbjct: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 3116
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
Q ++ Q EK R + + + T+ E ++ + E ++ +
Sbjct: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 3171
Query: 800 YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 858
L++L + + QT+ L+ GE+ ++ L+++L ++ L Q + +DR
Sbjct: 3172 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 3224
Query: 859 KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 916
RL+ +FQ+ +E WL+ ++ + P+ K ++L+ +L++ + + L
Sbjct: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 3283
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 976
G + + G +L+S P EE+ L+N+L + W ++S+ ++Q +++
Sbjct: 3284 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 3338
Query: 977 KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1006
KD Q +K +ED + +++ L + L P+ R+
Sbjct: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 3398
Query: 1007 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1045
LEI N + +++G D + + AV QAK +EE+ L + Q
Sbjct: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
Query: 1046 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+K + + K +LE D N+ L++LRA+Q L + T LV
Sbjct: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
Query: 1103 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1160
+ + + + E+ LEV N + + L + Q R M L
Sbjct: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
Query: 1161 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1208
D+++ + A +D + + Q+E++ L + S E R ++ +
Sbjct: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3636
Query: 1209 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1261
+E + Q ++ E + R++QL L +D + L+ +A +A A
Sbjct: 3637 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3694
Query: 1262 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1319
W G V+ I +++ + K K+ + Q + N L L++ D D + +
Sbjct: 3695 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
E INA W +++K+V++R A L+E +F LE L+WL + E A +K
Sbjct: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3808
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
E K VK +++ + LQ ++ L +I +S E + D + +L+++
Sbjct: 3809 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3866
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1499
+W+EL K+ + LE K+ H + + + +L + + +L+ P+G +Q+
Sbjct: 3867 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3926
Query: 1500 QNDVHRAFKRELK 1512
Q H+A + +++
Sbjct: 3927 QIIRHKALEEDIE 3939
Score = 139 bits (349), Expect = 4e-32
Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)
Query: 104 QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q+ LQ + + K AN + ESK +EV + A+ + + + E V++Q
Sbjct: 2892 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2947
Query: 164 LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 219
L + +++ V + ++ ++ EN K++ E + + E+ R+
Sbjct: 2948 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 3004
Query: 220 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 279
+QLE+ + + L WL ++ + + P+ L+++ + KE E
Sbjct: 3005 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 3064
Query: 280 QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 329
++ + + E + + T G + V+ +L +N W+ +T S+ ++ +
Sbjct: 3065 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 3124
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 389
+YQ+ ++ + V + + + + + E K Q +E ++++L + +V
Sbjct: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 3182
Query: 390 TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 443
+ L G D +K +E L + RI +A++ ++ +Q
Sbjct: 3183 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 3242
Query: 444 SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
+++ L+ P+ A+++ Q + E+F K +N+ + G+ + ++ G++L
Sbjct: 3243 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 3301
Query: 492 QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 551
+ ++ ++ + L+ L + R+ + + + +Y+ +DL+ ++D
Sbjct: 3302 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
Query: 552 IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 611
+ K++ L D +++ L + K LN V ++ L +A + + +
Sbjct: 3362 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418
Query: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 669
I + A + A ++ +T + E+M + ++ V A LE
Sbjct: 3419 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 3474
Query: 670 VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 726
+ L + K+ E L Q+E L+ ++ ++D + + ++ A +
Sbjct: 3475 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3527
Query: 727 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 785
++ Q ++Q +F +V + + +E +FH ++ +F+Q ++
Sbjct: 3528 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585
Query: 786 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 842
I + + + + +++++ + + + + A+ E ++++ D L+ +L
Sbjct: 3586 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3643
Query: 843 SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 895
+LN + C +L++R K +EQ + + +F R L N+ EEA+ + +
Sbjct: 3644 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3697
Query: 896 PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 952
G E ++ ++L K+ +E PL+ L+Q+N G ++ SA + Q LE+ ++
Sbjct: 3698 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3754
Query: 953 QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1012
+ N +W +++ + ++ +++ + G+ + LE L L WL+ +
Sbjct: 3755 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3807
Query: 1013 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1064
P+ E +QE ++ + ++ V+ + ++G + + E + + +LE L S
Sbjct: 3808 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3867
Query: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
W LL + A+Q L L V+ K+
Sbjct: 3868 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3892
Query: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
F+ ++D+LS+ ++ + + + I + II+ KA +D+E +
Sbjct: 3893 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
Query: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
+ + Q+L + TS E + +++++I+ +Q ++ E+Q+ + L++ L ++ + E
Sbjct: 3947 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005
Query: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
+ E L + KL S + D + ++ + L +++ + NVD A LL
Sbjct: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065
Query: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
+ + ++ + + I + I S+ LE+ +L +F E+ WL E
Sbjct: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Query: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1419
E ++ + + + ++ ++L+ E+ H V ++E S+ +L
Sbjct: 4126 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179
Query: 1420 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1479
R+ EG D V + N ++ + ++A+ + ++ + L W+
Sbjct: 4180 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 4233
Query: 1480 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1539
+L PI + Q V +AF +++ +R + +++
Sbjct: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 4274
Query: 1540 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1599
L+ E+ + T +L+++ E + ++E ++L +++ +++ + + E
Sbjct: 4275 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
Query: 1600 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
+EL + + + P + + L+ E+++ LR IA K ++ + + QL
Sbjct: 4334 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 4392
Query: 1660 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1693
+L+P +E+ + + + +++ VRQ
Sbjct: 4393 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
Score = 120 bits (300), Expect = 2e-26
Identities = 252/1367 (18%), Positives = 508/1367 (37%), Gaps = 188/1367 (13%)
Query: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
+A + +EL+ + + + LE + I K + +D + K L D
Sbjct: 1843 QAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTW 1902
Query: 491 QQRITDERKREEIKIKQQLLQTKH--NALKDLRSQRRKKALEISHQWYQYKRQADDLLKC 548
R+ + EI+ + L Q L+DLR+ K L ++ + + D L C
Sbjct: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC 1962
Query: 549 LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 608
L E L +P ERK +L+A+ + + A Q+
Sbjct: 1963 LQQYE----DLKQPMAERKA------------QLDALAFDIQFFISEHAQDLSPQQNRQM 2006
Query: 609 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 668
+ E++ F AQ+ ++ + E + + +T ++ + +
Sbjct: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG 2066
Query: 669 EVEQLLNAPD--LCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQS----A 722
+ E+ L +D L K + LK+++D +Q + + ++
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
Query: 723 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD-------------- 768
+P E L+E L Q Q+E + + + Q + +V + +
Sbjct: 2127 SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKK 2186
Query: 769 IKIFNQWLTEA------------------------------EQFLRKTQIPENWEH---- 794
I W+T + ++ Q PE +
Sbjct: 2187 IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM 2246
Query: 795 --AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 852
A+++ L + Q+ I Q+ L+ G + + + +LQ+KLG L ++
Sbjct: 2247 MKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ----MLQQKLGELKEQYSTSL 2302
Query: 853 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKL 911
Q K+++ ++ L +F +D EF WLE ++ + ++ + L L++
Sbjct: 2303 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 2362
Query: 912 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 971
E++ +G L+ + +G VL +EN K+ ++ E
Sbjct: 2363 FSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------------GKEPSE 2399
Query: 972 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
I +KD KL+D E+ L + + + L + + + +QA
Sbjct: 2400 IGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
Query: 1032 QPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+ +VE++LS + +E+ AT K+ E+L+ V +L + +A +
Sbjct: 2454 EANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK--------VARDI 2503
Query: 1088 TTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1142
I P + V T +++ + + S E S L + + L +
Sbjct: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
Query: 1143 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELITAAQNLKNKTSN 1199
++Q ++ ++V I E + QD+ +++ LE E++T +T++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM----ETAD 2619
Query: 1200 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
++ ++ + +++++ Q + L ++L + + + +Q + L
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
Query: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
S + + ++I E L ++ Q N+D L +L A D +
Sbjct: 2680 ASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV 2736
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
+N+ + + K V ERE L +F + F WL E E + + + +
Sbjct: 2737 QNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE 2796
Query: 1380 LLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENSQKILRSLEGS-- 1425
L + + +K L+ W L EI NL + IL S+ S
Sbjct: 2797 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2856
Query: 1426 --------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1477
D +Q + ++N K+ +L + L+A ++ + +H +L WL
Sbjct: 2857 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2916
Query: 1478 QLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLE 1535
+ K++ L + V+ Q + ++AF EL+ P I E L
Sbjct: 2917 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------LA 2967
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 1595
GL Y P + A+N +K EE+N+ WE+ + QR+++E+ L
Sbjct: 2968 GLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQRQLEESASHLACF 3017
Query: 1596 QEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVND 1653
Q A +L L + E++ G +G L ID L ++V+ + E ++ +N+
Sbjct: 3018 QAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Query: 1654 LARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1697
A+ + T + LS + L+ +N +W L + R Q+ +A
Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 3121
Score = 119 bits (297), Expect = 5e-26
Identities = 248/1464 (16%), Positives = 575/1464 (39%), Gaps = 237/1464 (16%)
Query: 329 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD 388
L+ QK T Q ++ + W+ QA+ L + + QQ L++ +++L D++ +
Sbjct: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
Query: 389 STRDQAANLMAN----RGDHCRKLVEPQISELNHRF--AAISHRIKTGKASIPLKELEQ- 441
+ A ++ + ++ KL +++ L + A + + + KELE+
Sbjct: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 2162
Query: 442 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQR--------GDNLQQR 493
S +Q+ E +A + N K+ D D + +LL G +L++
Sbjct: 2163 VTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
Query: 494 ITD----------------------ERKREEIKIKQQ------------LLQTKHNALKD 519
D + + +E+ +QQ L Q HN +
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
Query: 520 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQ- 576
+ ++K E+ Q+ Q++ LK + ++ +L + E + ++ ++EL+
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
Query: 577 -----KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS-KRWREIESKFAQFRRLNFAQI 630
E L ++ ++ SED + + + +S ++ ++E+ F + + ++I
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP--SEI 2400
Query: 631 HTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD-------LCAKD 683
+ ++ + TE + + S +H++ L + Q N+ D C +
Sbjct: 2401 GNLVKDKLKDATE----RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 2456
Query: 684 FEDLF------------KQEESLKNIKDSLQQSSGRIDIIH--SKKTAALQSATPVERVK 729
E L +Q + K +++ L + ++ + ++ ++ +
Sbjct: 2457 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2516
Query: 730 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP 789
+QE + ++ ++ +R +++ + + ++ Q + E EQ L Q+
Sbjct: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV- 2575
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVR---TLNATGEEI---IQQSSKTDASILQEKLGS 843
+ L + +Q + R +L AT E + ++ + T A++LQ KL
Sbjct: 2576 ---SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2632
Query: 844 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE---- 899
++ R++++C Q +++ L++ F+ + ++E + + +P ++
Sbjct: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
Query: 900 -QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 958
QQ++E +++ E L + ++ +L+ G + + + QD+++N K
Sbjct: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC-----QHQDRVQNLRKD----- 2742
Query: 959 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1018
E Q ++ + KD +++L++ + + WL + P E
Sbjct: 2743 ------FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI-----PPTETS 2791
Query: 1019 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 1078
+E E ++ + +++ SKG +E+++ + ++ L+ E+ A
Sbjct: 2792 MSAKELEKQIEHLKSLLDDWASKG--------------TLVEEINCKGTSLENLIMEITA 2837
Query: 1079 KQPDLAPG--LTTIGAS--------PTQTVTLVTQPVVTKETAISKL-----EMPSSLML 1123
G L ++G+S + +T + + KL E SL
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897
Query: 1124 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVG--DLEDINEMIIKQKATMQDLEQRRP 1181
+ + + ++ + WL ++V+KS M E + KA + +LEQ P
Sbjct: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2957
Query: 1182 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1241
+++++ A L ++T + W ++QE L +R ++ E+ +
Sbjct: 2958 KIQKVKEALAGL-----------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ 3006
Query: 1242 LEAKEEAEQVLGQARAKLESW---KE------GPYTVD--AIQKKITETKQLAKDLRQWQ 1290
LE A ++L W KE GP ++D + + + + + K+ +
Sbjct: 3007 LEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARR 3066
Query: 1291 TNVDVANDLALKLLR---DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLL 1347
+ N+ A +L D S T +V ++IN W + +++ R + +++
Sbjct: 3067 QQHEQLNEAAQGILTGPGDVSL-STSQVQKELQSINQKWVELTDKLNSRSSQIDQA---- 3121
Query: 1348 QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKE-LMKQWQDLQGEIEAHTD 1406
+ ++ +LQD + K R + V+ + Q + ++ ++E ++
Sbjct: 3122 -------------IVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE 3168
Query: 1407 VYHNLDENSQKILRSLEGSDDAVL----------LQRRLDNMNFKWSELRKKSLNIRSHL 1456
+ +L++ ++ + D+ + L++RL+ + L + + + L
Sbjct: 3169 IRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL 3228
Query: 1457 EASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEP 1516
+A+ ++ EL WL K + ++ PI +Q Q + F++ L
Sbjct: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS- 3287
Query: 1517 VIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNL 1576
+ E + EG L P P EE+ R L+ Q E+ WE+L+
Sbjct: 3288 ---GSYEVI-------VAEGESLLLSVP---PGEEK-----RTLQNQLVELKNHWEELSK 3329
Query: 1577 HSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKGSWQPVGDLLIDSLQDHL 1631
+AD Q ++ + +++ Q+ Q ++L D K + +E ++ + PV L+ L
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE-LRVTLDPV------QLESSL 3382
Query: 1632 EKVKALRGEIAPLKENVSHVNDLA 1655
+ KA+ E+ + + +N A
Sbjct: 3383 LRSKAMLNEVEKRRSLLEILNSAA 3406
Score = 67.8 bits (164), Expect = 1e-10
Identities = 156/927 (16%), Positives = 349/927 (37%), Gaps = 160/927 (17%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--- 68
+K RQ LE ++ + + + +L + LT ++ L A D + E K
Sbjct: 4753 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV 4812
Query: 69 IQSDLTSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR------- 115
+++D+ +H+ ++E + K + + A + S+++ + + V K
Sbjct: 4813 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4872
Query: 116 -LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
Q+ F +++ + L ++ L A + E + QL+ + LY L +
Sbjct: 4873 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4932
Query: 175 VEMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 233
++ GR ++ + + + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + +
Sbjct: 4933 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4992
Query: 234 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 293
+ WL + L S + + + S++ K E+ + + + + G
Sbjct: 4993 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 5052
Query: 294 LKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 352
LK + K++ L+++ L + S W V R+ I
Sbjct: 5053 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------I 5084
Query: 353 QADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ LD++ +K+ +Q + K+L L D +DS + ++N D
Sbjct: 5085 ERGRSLDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD--------- 5129
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 472
K + L + ++F + + I+ G LKE+ +
Sbjct: 5130 ------------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 5171
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ + + E+ + D + + + + + E + L S + AL+
Sbjct: 5172 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQAL 5217
Query: 533 HQW-YQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEG 591
W Y+ + Q + D++ + + D K+ +EL K+ + ++R
Sbjct: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRE 5271
Query: 592 LSEDGA--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMP 646
L E+ V+ +LS RW + + ++ RL A Q R+ M++
Sbjct: 5272 LIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE 5331
Query: 647 LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG 706
E + L + T Q+L++ + E + K EE ++ ++
Sbjct: 5332 AEQTLRFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEV 5379
Query: 707 RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 766
+ + H ++ + R + +E L+ W K Q R + ++ +
Sbjct: 5380 ILAVCHPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANA 5428
Query: 767 YDIKIFNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTL 818
++ W+ AE L + IP+N + K ++ +++E+ V +T
Sbjct: 5429 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 5488
Query: 819 N----------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLS 856
+ G + + Q + IL + ++ L+ RWQ+V
Sbjct: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
Query: 857 DRKKRLEEQKNILSEFQRDLN-EFVLW 882
+R+++L + + L E + N +F +W
Sbjct: 5549 ERQRKLNDALDRLEELKEFANFDFDVW 5575
Score = 44.7 bits (104), Expect = 0.001
Identities = 114/578 (19%), Positives = 219/578 (37%), Gaps = 111/578 (19%)
Query: 1109 ETAISKLEMPSSLMLEVPALADFNRAWTELTDWL---SLLDQVIKSQRVMVG-DLEDINE 1164
E +S L + ++ + + EL D L +L++ +K +V +LE +N+
Sbjct: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867
Query: 1165 MIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHL 1224
+II Q E L+ L A+NL+ S+ R+ QN + + +
Sbjct: 1868 IIISQPQ-----EVPAQLLKALEKDAKNLQKSLSS--VSDTWNSRLLHFQNAVEIEKTKV 1920
Query: 1225 QNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK 1284
N+ QL L+D W+ K +L + E VD++ + + + L +
Sbjct: 1921 LNQHTQLEGRLQDLRAWVGNKN---LILNSKGSNSE------IDVDSLNLCLQQYEDLKQ 1971
Query: 1285 DLRQWQTNVD-VANDLALKL---LRDYSADDTRKVHMITENINASWRSI----------- 1329
+ + + +D +A D+ + +D S R++ + + S++ I
Sbjct: 1972 PMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDAL 2031
Query: 1330 --HKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGV 1387
H + E+EA ++ + LE +W+ +AE Q T ++ L K
Sbjct: 2032 QGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQ 2091
Query: 1388 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSE 1444
+L +DLQ +I+ N + +++ +EG + L R L +
Sbjct: 2092 SDL----KDLQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TA 2133
Query: 1445 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
LR+K + EA ++ + L+E + A+Q++ +
Sbjct: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVT-------------------SALQQETEKS 2174
Query: 1505 RAFKRELKTKEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQE 1543
+A K + K+ + + S + LT P G+E+L Y
Sbjct: 2175 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMG 2232
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEA 1598
+ P E+ +++ + +E+ ++ + L + Q +D+ T E Q LQ+
Sbjct: 2233 VNQAP--EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 2290
Query: 1599 TDEL----DLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1632
EL L Q+E Q + D L LQDH E
Sbjct: 2291 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 249 bits (635), Expect = 3e-65
Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)
Query: 16 RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 68
R+ K L + +A+E E ++ + I++QLA + ++VD QM +
Sbjct: 3173 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3232
Query: 69 --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 119
IQS D+ E +EE+ + K+ AQR+ +LQ+ +
Sbjct: 3233 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3279
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 179
F+ L+ L + + + + S E +VV++Q+ L + L + K+ V+M+
Sbjct: 3280 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3338
Query: 180 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 239
G +I Q + + +++ ++ +L+ + EL +K R++QLE L L+++ + +
Sbjct: 3339 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3398
Query: 240 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 299
+++L+ T+ +L V + + ++ KA +++IE + ++G++L ++
Sbjct: 3399 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3458
Query: 300 KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 358
E ++ +K+ L + + + R LL + + F ++ + W+ + + L
Sbjct: 3459 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 3518
Query: 359 DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 411
K K+DVL R L E+ + + VD L+ L++
Sbjct: 3519 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 3576
Query: 412 QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 471
++ + R+A I+ + + KA L++ Q + Q E L +++ ++EE
Sbjct: 3577 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 3631
Query: 472 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 530
+ + QR L++ + + R + + AL +L R ++ L+
Sbjct: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 3685
Query: 531 -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 583
+S QYK +D + + +D+I+ + R ++ + D EL ++K L
Sbjct: 3686 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 3740
Query: 584 AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 638
+R + + + A + V+ I + + ++ F+ F Q ++E+T
Sbjct: 3741 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 3797
Query: 639 MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
++ + + + + + + +S + E L+ A D E
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 3857
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E ++ +++S+ + ID + K L+ P E ++E + + + ++ +
Sbjct: 3858 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 3916
Query: 747 MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 802
+ R D +V + + FH I+ + L LR IP E K + +
Sbjct: 3917 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 3974
Query: 803 ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 855
+ + + + Q L GEE+I +S D + +Q+KL + W+++ +
Sbjct: 3975 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4034
Query: 856 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 914
+R+ + + + +F D+ + +++ +I PG + + K+++E + + E
Sbjct: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
E L+ + G ++ + E+ ++ + + N W +++ E+ ++E
Sbjct: 4095 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ + + L++ ++ L P+ L E ++E ++ V +
Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4208
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E++ +G+ + K+ AT R + + L EL+ +L
Sbjct: 4209 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4250
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ A + ++ +L+ AL F A EL WL+ ++++ +
Sbjct: 4251 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4290
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
QR + GD + I + K D+ + +E + A L ++ +A + + R+E
Sbjct: 4291 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4349
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ W+ V + + R QQL L+ + + E+ L + ++L + K +
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4409
Query: 1272 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
++++ +L L+ + +T + + L LL + K + W +
Sbjct: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4469
Query: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
++ ER++ LEE L +F L++F+ WLT AE + N+ A+ +L V
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 4523
Query: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
+++ + E+ AH D LD+ + L+ L D VL++ L ++ +W ++ ++S+
Sbjct: 4524 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 4582
Query: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
L+ + + K+ H + ++L+ WL+ + L + I D ++ Q H+ F++
Sbjct: 4583 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 4642
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
L K+PV +T+ T R + + L PE+ +Q + L EV +
Sbjct: 4643 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 4683
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1629
W+ + S + Q K++E L + +A L L + E QPV GDL D + +
Sbjct: 4684 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 4741
Query: 1630 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1686
++ K + E+ V + R+L + + L++L+TRW L V+
Sbjct: 4742 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 4801
Query: 1687 VEDRVRQ 1693
+ R+ Q
Sbjct: 4802 KQSRLEQ 4808
Score = 218 bits (555), Expect = 6e-56
Identities = 322/1681 (19%), Positives = 689/1681 (40%), Gaps = 194/1681 (11%)
Query: 13 KAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI-- 69
+ R+ LL+Q++ +A+ E + ++ DK + ++ D Q A +
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
Query: 70 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------- 114
++ + + ++++ K+ Q Q ++ + Q+KL + ++
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 3600
Query: 115 RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
+ Q F+ +E L EV+ L +S E + L K + E +
Sbjct: 3601 QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV 3660
Query: 175 VEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
++ V + R +++ + LD+ V+ Y + + +R +++ ++ S++ +
Sbjct: 3661 LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 3720
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV 290
+ W+A T +L + +++ KA +I + K + + +E+
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 291 ----GEALKTVLGKK-ETLVE--DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
GE KTVL +K E+L++ + +SLLNS A RA+ +N E + + +
Sbjct: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW--- 3837
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMAN 400
++ I Q + + E+ + QQ+E +++L+ + + +P +D Q L
Sbjct: 3838 IEETRALIAQLPSPAIDHEQLRQQQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPE 3895
Query: 401 RGDHCRKLVEPQISELNHRFAAISHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEA 455
G+ +VE + + + +A I ++ +A ++ +F+ I+ +LE LE
Sbjct: 3896 EGE----MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE- 3950
Query: 456 EIQQGVNLK-----EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 510
+ + + E D ++ DN+ EL + LQ ++R E +L+
Sbjct: 3951 NLSSRLRMPPLIPAEVDKIRECISDNKSATVEL----EKLQPSFEALKRRGE-----ELI 4001
Query: 511 QTKHNALKDLRSQRRKKALE-ISHQWYQYKRQADDL-LKCLD----------DIEKKLAS 558
A KDL ++ + L+ + W K +A++ +K LD D+ L +
Sbjct: 4002 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4061
Query: 559 LPEPRD---ERKIKEIDRELQKKK-EELNAVRRQAEGLSED-------GAAMAVEPTQIQ 607
+ + +D + + ID + K++ E ++ + +GL E+ GA + + +
Sbjct: 4062 IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETE 4121
Query: 608 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 667
+ + I+ + LN +E + + + M + Y + QA+
Sbjct: 4122 KPEVRKSIDEMNNAWENLN-----KTWKERLEKLEDAMQAAVQYQDTL---------QAM 4167
Query: 668 LE-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 722
+ V +L P + D + Q +K K + Q ++ ++ + L+ A
Sbjct: 4168 FDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4226
Query: 723 TP-VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQ 781
T +R ++E L++L WE + + RQ + + ++ +F + ++ WLT E+
Sbjct: 4227 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4286
Query: 782 FLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 838
L Q P + + + L + L++ + Q V T+N G E+++ S+ DAS L+
Sbjct: 4287 LL-DAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR 4345
Query: 839 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPG 897
+L ++N W+ V ++ +R+++L+ F ++ +F+L L ++ +++ G
Sbjct: 4346 SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGG 4405
Query: 898 KEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 957
+ +E+L+ L +L ++ QL + G +L+S S K E + +
Sbjct: 4406 LPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS-GSGSKTEQSVALLEQK 4464
Query: 958 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN--- 1014
W VS + E++ ++E + + + L++ + WL+ L I + P+
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQE-------FINWLTLAEQSLNIASPPSLIL 4517
Query: 1015 QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEWKAV 1069
++E ++ V A + + E+ G L +K +K L + S W+ V
Sbjct: 4518 NTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKV 4577
Query: 1070 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 1129
+ +E SL
Sbjct: 4578 VQ-----------------------------------------RSIERGRSLDDARKRAK 4596
Query: 1130 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 1189
F+ AW +L DWL + + S+ + D + I + K K + L ++P + I
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRT 4656
Query: 1190 AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 1249
+ LK KT E + + + ++++WD V R+ +L E L S Q+++A +
Sbjct: 4657 GRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALV 4716
Query: 1250 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 1309
L + +L + +D + + K K+L + V V +L+ + S
Sbjct: 4717 DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SR 4775
Query: 1310 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT-- 1367
DDT V + ++ W ++ K +++ LE+ + + F + L WL+EAE T
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
L D T + L D+ KE MK+ ++ + ++ + + +++ ++ D
Sbjct: 4836 FRGALPDDTEALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPD 4885
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 1486
++ + + ++ E+ + + LE + + L+ELL W+Q + L +
Sbjct: 4886 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 4945
Query: 1487 --QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEG 1536
Q PI + V+ H+ F E+ K+P + +E E+ G
Sbjct: 4946 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSG 5005
Query: 1537 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1596
K +P PP + + + +++ W+++ L + + QRK+++ L+RL+EL+
Sbjct: 5006 GRKSLSQP--TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELK 5063
Query: 1597 E 1597
E
Sbjct: 5064 E 5064
Score = 211 bits (538), Expect = 5e-54
Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)
Query: 96 VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 155
+LS+ QK+L+D+ + + F + A + L + L E + +Q
Sbjct: 3370 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3423
Query: 156 SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 215
Q+ L + + ++V +K G+ + L E++ +L+ Y+E+ +
Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483
Query: 216 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 275
+ L++ L +R ++ + WLA + +L+ + L + A A +
Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 3543
Query: 276 EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 334
EI +K ++ + G+AL K G++ L+++KL + + + +T + + L L + +
Sbjct: 3544 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 3603
Query: 335 KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 389
+ F + +T W+ + + L S + P Q + K LK E+ + R +D+
Sbjct: 3604 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 3663
Query: 390 TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 443
+ + L+ R+ ++ +S+ N ++ +S I + + ++ +Q+ +
Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
Query: 444 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 496
+++ + E + G E+D + + ++++ D++ + +
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 3783
Query: 497 --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 554
E ++ ++ K + L ++ A+ L S+R + Q+ ++L +++
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
Query: 555 KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 611
+A LP P D ++++ E+++ +E + + + L + G + + P + ++ ++
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 3903
Query: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 671
+++ E+ +AQ ++EE V + L+ + ST +TE + +LE
Sbjct: 3904 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
Query: 672 QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+ L++ P L + + + + K+ L++ + + + + + ++
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
Query: 728 ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 783
++Q+ L Q+ F WE + ++R+ +F +E +F YD+ + + + +
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
Query: 784 RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 835
+ P + E A+ +KE DG+ + +R L G ++I +T+
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4123
Query: 836 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 894
+++ + +N W+ + K +R ++LE+ ++Q L WL+ + ++P
Sbjct: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
Query: 895 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 954
+K++L ++K E+ +Q +++LN G +L A ++D + L +
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4242
Query: 955 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1014
W + + +Q ++E + LGQ + LE+L + WL+ L+ Q
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4293
Query: 1015 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1064
G V E E+A V A Q VE + G L + ++ +LE ++
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353
Query: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
W++V LQ+ ++ L L ++ ++ + M S L
Sbjct: 4354 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4400
Query: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
P A +L + L Q+ + E N+++ K + +
Sbjct: 4401 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4442
Query: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
L S ++T + ++ +W V ++ R+ +L E L +T++ +
Sbjct: 4443 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4492
Query: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
+E L A L ++ + +I E K A ++ + + + +L
Sbjct: 4493 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 4552
Query: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
D + + ++ + W + +R ER +L++ + +QF +K + WL +A
Sbjct: 4553 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 4612
Query: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1424
E+ + + + D +K + + ++ Q + VY + +
Sbjct: 4613 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 4666
Query: 1425 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1484
+D+ L L + KW + KS+ + LE + + +LQ L+ WL + +L
Sbjct: 4667 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 4726
Query: 1485 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+ P+ GD V D H+ F++EL + + + L +
Sbjct: 4727 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 4767
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
REL E +++ T ++ Q +E++T W+ + S Q ++++ L++ + ++ L
Sbjct: 4768 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Query: 1605 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1641
L +AE + D LID+ ++ ++KV+ R ++
Sbjct: 4826 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868
Score = 209 bits (531), Expect = 3e-53
Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 78
LE+ Q +E ++S I++ + QL + + + + + ++ + Q L + E
Sbjct: 2943 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
Query: 79 SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 123
++ ++ QG A ++L Q +VAQ++ +V + + F
Sbjct: 3003 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062
Query: 124 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 183
R++E L ++ L + + + +QSQ+ + +K ++E R
Sbjct: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122
Query: 184 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 243
+++++ T + L + AL +L + R++QLE L +++ L +
Sbjct: 3123 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3182
Query: 244 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 302
A + + V ++ ++A K QKE ++ ++ L+ + +G+ L GK
Sbjct: 3183 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3242
Query: 303 TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 360
+ +E + +N+ W + + + + L E H F ++ + W+ + L+
Sbjct: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3300
Query: 361 SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 413
+ +K P + V+K L+ L+D + VD + + + + R+ + Q+
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360
Query: 414 SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 453
L R+ + KA+ K+LE F S +K L EP+
Sbjct: 3361 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 454 ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 510
A+IQQ + ++ + +D+ E++ V + ++ G +L +T ++ + K L
Sbjct: 3416 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3472
Query: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
Q +++ ++D ++ + + ++L L ++E KL+S+ +K+
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 3525
Query: 571 IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 622
+++ ++ EE+ ++ + ++G A+ + T ++ +++
Sbjct: 3526 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 3581
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+ +A I + + + + L + STY ++ L EVE+ L +
Sbjct: 3582 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 3635
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
E + + ++ K +K + + +D ++ A L+ R L + +S + Q++
Sbjct: 3636 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 3695
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 799
V+ R D ++++ +++ W+ E ++ L ++ ++ A+ +
Sbjct: 3696 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 3754
Query: 800 YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K I + + + L + EI + ++LQEK SL +++ + S+R
Sbjct: 3755 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 3814
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
RLE + ++++F E W+EE IA +P +QL+++ E+++ L E +
Sbjct: 3815 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 3874
Query: 919 RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 975
+ + +L + G + ++PEE + +E K ++ + ++ + ++ E +Q
Sbjct: 3875 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 3931
Query: 976 IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1029
+ + K+E + E L +L L + P+ +++ N+ ++++ + + +
Sbjct: 3932 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 3991
Query: 1030 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1079
A + EE++ + Q K+ A + ++ KL+ + W+ + +E K
Sbjct: 3992 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4050
Query: 1080 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1111
D+A LTTI SP +++ Q V ET
Sbjct: 4051 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4110
Query: 1112 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1141
K E+ S+ A + N+ W E + DW
Sbjct: 4111 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4170
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
L + + + DL + + + + K ++ Q++ ++E+L + + K +++
Sbjct: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
Query: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1261
R II + + +++ W+ + E + +R+ +L L Q+ A EE L L++
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290
Query: 1262 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1321
+ I+ ++ + L D+ Q V+ N +LL + DD + E
Sbjct: 4291 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4350
Query: 1322 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1381
+N W S+ ++ ERE L+ T + Q F ++E FL LT E+ + A++ L
Sbjct: 4351 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4406
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
++ +E + +L +++A + Y+ L + + +L S + S ++ + + K
Sbjct: 4407 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1501
W + K +S LE + + SLQE + WL L + L+ +P V Q
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524
Query: 1502 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1561
+ H+ F E+ I+ +L Q +L + Q+V L++
Sbjct: 4525 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 4564
Query: 1562 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1620
V + WEK+ S + R +D+ +R ++ EA +L L AE S +
Sbjct: 4565 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624
Query: 1621 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1678
D + L H E K L G+ P+ + ++ T L + + L ++
Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 4682
Query: 1679 RWKLLQVAVEDRVRQLHEA 1697
+W + +R +L EA
Sbjct: 4683 KWDTVCGKSVERQHKLEEA 4701
Score = 155 bits (393), Expect = 3e-37
Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)
Query: 145 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 202
+T + + V+Q QL L + L+E + VE + K R I++ + P + + E
Sbjct: 1961 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2020
Query: 203 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
++ H+ L + ER L+K + S+ +++ + L + + + L +
Sbjct: 2021 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2080
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 313
+ +A +++I +QK L++ E V ++T +++ KL+ ++
Sbjct: 2081 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2140
Query: 314 ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 357
S+ + +AE + +L + Q+ ME DQ++ H + I + +
Sbjct: 2141 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2199
Query: 358 LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 410
E + Q+ D L+ L EL+ +D +D+ NL + + + + E
Sbjct: 2200 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2255
Query: 411 ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 457
Q+ E +K + SIP E +++K +E L++ +
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2315
Query: 458 QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 510
+ +N K + E D++G +L + + + EI+ +
Sbjct: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375
Query: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
K+ L + +R++ I ++ + ++A+ +L+ L+ E+ L S+ K +
Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2435
Query: 571 IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 626
+ + + K EL + + + E A + V Q ++ W++I+ + +++ R
Sbjct: 2436 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2495
Query: 627 FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 679
+ R EE+ + E P E+ L ++ +LNA
Sbjct: 2496 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 2555
Query: 680 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 739
K+FE +Q E L + G + + S+ LQS + V+L + L+
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 2614
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
Q ++ Q EK R + + + T+ E ++ + E ++ +
Sbjct: 2615 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 2669
Query: 800 YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 858
L++L + + QT+ L+ GE+ ++ L+++L ++ L Q + +DR
Sbjct: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 2722
Query: 859 KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 916
RL+ +FQ+ +E WL+ ++ + P+ K ++L+ +L++ + + L
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 2781
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 976
G + + G +L+S P EE+ L+N+L + W ++S+ ++Q +++
Sbjct: 2782 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 2836
Query: 977 KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1006
KD Q +K +ED + +++ L + L P+ R+
Sbjct: 2837 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 2896
Query: 1007 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1045
LEI N + +++G D + + AV QAK +EE+ L + Q
Sbjct: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
Query: 1046 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+K + + K +LE D N+ L++LRA+Q L + T LV
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
Query: 1103 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1160
+ + + + E+ LEV N + + L + Q R M L
Sbjct: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3074
Query: 1161 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1208
D+++ + A +D + + Q+E++ L + S E R ++ +
Sbjct: 3075 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3134
Query: 1209 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1261
+E + Q ++ E + R++QL L +D + L+ +A +A A
Sbjct: 3135 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3192
Query: 1262 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1319
W G V+ I +++ + K K+ + Q + N L L++ D D + +
Sbjct: 3193 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
Query: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
E INA W +++K+V++R A L+E +F LE L+WL + E A +K
Sbjct: 3252 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3306
Query: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
E K VK +++ + LQ ++ L +I +S E + D + +L+++
Sbjct: 3307 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3364
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1499
+W+EL K+ + LE K+ H + + + +L + + +L+ P+G +Q+
Sbjct: 3365 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3424
Query: 1500 QNDVHRAFKRELK 1512
Q H+A + +++
Sbjct: 3425 QIIRHKALEEDIE 3437
Score = 142 bits (359), Expect = 3e-33
Identities = 328/1739 (18%), Positives = 672/1739 (38%), Gaps = 276/1739 (15%)
Query: 25 IQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMK 84
I + T++ L ++ L + + +++ ++ +P ++S+L L E
Sbjct: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT----LRSELNL----LVEKM 1142
Query: 85 KHNQGKEAAQ-RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 143
H G L +DV + +QD + + +E +L + +++L + L A
Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVK------GYEIKLSQEEVVLAD----LSA 1192
Query: 144 LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP-KELD---- 198
LE S L H ++ K + V S ++ I + + ++ P + LD
Sbjct: 1193 LEAH-------WSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245
Query: 199 -ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 257
E+ + L+ ++ + A++ R+ +LE ++ R L +W+ T + +
Sbjct: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305
Query: 258 GMPSNLDSE-VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 316
S + SE ++ A EIE+ + L + + T++ E + + + S
Sbjct: 1306 AEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQ 1365
Query: 317 IAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 366
+ R +E+++L Y + Q+V K+I A L+E EK
Sbjct: 1366 KSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHV----KYISDALRRLEEEEKVVE 1421
Query: 367 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK-LVEPQI--SELNHRFAAI 423
++K++ ++++K L + +T+ +A + K ++E Q+ EL + +
Sbjct: 1422 EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQV 1481
Query: 424 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKEL 483
S IKT + + KL E + +I + +N NK ++ +G+ +L
Sbjct: 1482 SEAIKTSQIFLAKHG--------HKLSEKEKKQISEQLNA----LNKAYHDLCDGSANQL 1529
Query: 484 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQ 541
Q LQ ++ + +++ ++ KQQ T H L+DL S + ++AL HQ ++
Sbjct: 1530 QQ----LQSQLAHQTEQKTLQ-KQQ--NTCHQQLEDLCSWVGQAERALA-GHQGRTTQQD 1581
Query: 542 ADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV 601
L K D+ K++ ++Q + V + EG E+
Sbjct: 1582 LSALQKNQSDL----------------KDLQDDIQNRATSFATVVKDIEGFMEEN----- 1620
Query: 602 EPTQIQLSKR-WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 660
Q +LS R + K Q + Q ++EET + E + ++ L +
Sbjct: 1621 ---QTKLSPRELTALREKLHQAKE----QYEALQEETRVAQKE-----LEEAVTSALQQE 1668
Query: 661 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 720
T S+A AK+ + K+ ++L + S+ S G++ L
Sbjct: 1669 TEKSKA--------------AKELAENKKKIDALLDWVTSVGSSGGQL-------LTNLP 1707
Query: 721 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 780
+ L++ + VN+ + + D+ E + H ++ L++ +
Sbjct: 1708 GMEQLSGASLEKGALDTTDGYMGVNQAPE----KLDKQCEMMKARHQEL------LSQQQ 1757
Query: 781 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 840
F+ TQ + + L+ G + + + +LQ+K
Sbjct: 1758 NFILATQSAQAF-------------------------LDQHGHNLTPEEQQ----MLQQK 1788
Query: 841 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKE 899
LG L ++ Q K+++ ++ L +F +D EF WLE ++ + ++
Sbjct: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
Query: 900 QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWI 959
+ L L++ E++ +G L+ + +G VL +EN K+
Sbjct: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------ 1891
Query: 960 KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF 1019
++ EI +KD KL+D E+ L + + + L + +
Sbjct: 1892 ------GKEPSEIGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Query: 1020 DVQETEIAVQAKQPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 1075
+ +QA + +VE++LS + +E+ AT K+ E+L+ V +L +
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK- 1996
Query: 1076 LRAKQPDLAPGLTTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALAD 1130
+A + I P + V T +++ + + S E S L +
Sbjct: 1997 -------VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2049
Query: 1131 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELI 1187
+ L + ++Q ++ ++V I E + QD+ +++ LE E++
Sbjct: 2050 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2109
Query: 1188 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 1247
T +T++ ++ ++ + +++++ Q + L ++L + + +
Sbjct: 2110 TRFM----ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK 2165
Query: 1248 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 1307
+Q + L S + + ++I E L ++ Q N+D L +L
Sbjct: 2166 LQQFMENKSRMLASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCG 2222
Query: 1308 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
A D + +N+ + + K V ERE L +F + F WL E E +
Sbjct: 2223 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282
Query: 1368 ANVLQDATRKERLLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENS 1415
+ + + L + + +K L+ W L EI NL +
Sbjct: 2283 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKT 2342
Query: 1416 QKILRSLEGS----------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1465
IL S+ S D +Q + ++N K+ +L + L+A ++ +
Sbjct: 2343 GSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402
Query: 1466 LHLSLQELLVWLQLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLE 1523
+H +L WL+ K++ L + V+ Q + ++AF EL+ P I E
Sbjct: 2403 VHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKE 2462
Query: 1524 TVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 1583
L GL Y P + A+N +K EE+N+ WE+ + QR
Sbjct: 2463 A---------LAGLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQR 2503
Query: 1584 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEI 1641
+++E+ L Q A +L L + E++ G +G L ID L ++V+ + E
Sbjct: 2504 QLEESASHLACFQAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEF 2560
Query: 1642 APLKENVSHVNDLARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1697
++ +N+ A+ + T + LS + L+ +N +W L + R Q+ +A
Sbjct: 2561 EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 2619
Score = 139 bits (349), Expect = 4e-32
Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)
Query: 104 QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q+ LQ + + K AN + ESK +EV + A+ + + + E V++Q
Sbjct: 2390 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2445
Query: 164 LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 219
L + +++ V + ++ ++ EN K++ E + + E+ R+
Sbjct: 2446 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 2502
Query: 220 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 279
+QLE+ + + L WL ++ + + P+ L+++ + KE E
Sbjct: 2503 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 2562
Query: 280 QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 329
++ + + E + + T G + V+ +L +N W+ +T S+ ++ +
Sbjct: 2563 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 2622
Query: 330 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 389
+YQ+ ++ + V + + + + + E K Q +E ++++L + +V
Sbjct: 2623 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 2680
Query: 390 TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 443
+ L G D +K +E L + RI +A++ ++ +Q
Sbjct: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740
Query: 444 SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
+++ L+ P+ A+++ Q + E+F K +N+ + G+ + ++ G++L
Sbjct: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 2799
Query: 492 QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 551
+ ++ ++ + L+ L + R+ + + + +Y+ +DL+ ++D
Sbjct: 2800 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 2859
Query: 552 IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 611
+ K++ L D +++ L + K LN V ++ L +A + + +
Sbjct: 2860 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916
Query: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 669
I + A + A ++ +T + E+M + ++ V A LE
Sbjct: 2917 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
Query: 670 VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 726
+ L + K+ E L Q+E L+ ++ ++D + + ++ A +
Sbjct: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3025
Query: 727 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 785
++ Q ++Q +F +V + + +E +FH ++ +F+Q ++
Sbjct: 3026 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083
Query: 786 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 842
I + + + + +++++ + + + + A+ E ++++ D L+ +L
Sbjct: 3084 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3141
Query: 843 SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 895
+LN + C +L++R K +EQ + + +F R L N+ EEA+ + +
Sbjct: 3142 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3195
Query: 896 PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 952
G E ++ ++L K+ +E PL+ L+Q+N G ++ SA + Q LE+ ++
Sbjct: 3196 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3252
Query: 953 QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1012
+ N +W +++ + ++ +++ + G+ + LE L L WL+ +
Sbjct: 3253 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3305
Query: 1013 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1064
P+ E +QE ++ + ++ V+ + ++G + + E + + +LE L S
Sbjct: 3306 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365
Query: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
W LL + A+Q L L V+ K+
Sbjct: 3366 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3390
Query: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
F+ ++D+LS+ ++ + + + I + II+ KA +D+E +
Sbjct: 3391 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
Query: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
+ + Q+L + TS E + +++++I+ +Q ++ E+Q+ + L++ L ++ + E
Sbjct: 3445 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 3503
Query: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
+ E L + KL S + D + ++ + L +++ + NVD A LL
Sbjct: 3504 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 3563
Query: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
+ + ++ + + I + I S+ LE+ +L +F E+ WL E
Sbjct: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Query: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1419
E ++ + + + ++ ++L+ E+ H V ++E S+ +L
Sbjct: 3624 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 3677
Query: 1420 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1479
R+ EG D V + N ++ + ++A+ + ++ + L W+
Sbjct: 3678 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 3731
Query: 1480 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1539
+L PI + Q V +AF +++ +R + +++
Sbjct: 3732 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 3772
Query: 1540 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1599
L+ E+ + T +L+++ E + ++E ++L +++ +++ + + E
Sbjct: 3773 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831
Query: 1600 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
+EL + + + P + + L+ E+++ LR IA K ++ + + QL
Sbjct: 3832 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 3890
Query: 1660 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1693
+L+P +E+ + + + +++ VRQ
Sbjct: 3891 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 3920
Score = 88.6 bits (218), Expect = 7e-17
Identities = 209/1165 (17%), Positives = 451/1165 (38%), Gaps = 201/1165 (17%)
Query: 614 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
E+E+ A+F+ L + + +EET+ M Y++E+ ++ L E EQ
Sbjct: 1021 EVEACKARFQHLMKSMENEDKEETVAKM--------------YISELKNIRLRLEEYEQR 1066
Query: 674 L--NAPDLCAKDFEDLFKQEESLK-----NIKDSLQQSSGRIDIIHSKKTAALQ-----S 721
+ L + + Q+ +L+ + ++ LQQ +D + K + L S
Sbjct: 1067 VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSS 1126
Query: 722 ATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQ 781
+ P R +L + ++D + ++ +Y ++ D V + +K + L++ E
Sbjct: 1127 SVPTLRSELNLLVEKMDHVYG-LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185
Query: 782 FLRKTQIPE-NWEHAKYKWYLKELQDGIGQRQTVVRTLN---ATGEEIIQQSSKT----- 832
L E +W ++ +L +++D + +V L+ A + + +Q S+
Sbjct: 1186 VLADLSALEAHWSTLRH--WLSDVKD----KNSVFSVLDEEIAKAKVVAEQMSRLTPERN 1239
Query: 833 -DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS 891
D QEK L RW V QL R+ LE + +L +++ + W+EE
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299
Query: 892 IPLEPGKEQQ---LKEKLEQVKLLVEELPLRQGILKQLNETGGPV----------LVSAP 938
+ ++PG+ + L E+L Q L E+ Q L Q + L++
Sbjct: 1300 M-MKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 939 ISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA-------QIKDLGQLEKKLEDLE- 990
E Q K K ++ +++ + + A +K + ++LE+ E
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
Query: 991 ----------EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1040
E++ LL W+S + N +G ET+ + ++ +E+ +
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLAR--------NTQGKATSSETKESTDIEKAILEQQVL 1470
Query: 1041 KGQHLYKEKPATQPVK----------RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
+ K++ ++ +K KL + E K ++ L L DL G
Sbjct: 1471 SEELTTKKEQVSEAIKTSQIFLAKHGHKLSE--KEKKQISEQLNALNKAYHDLCDG---- 1524
Query: 1091 GASPTQTVTLVTQPV-VTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVI 1149
S Q L +Q T++ + K + LE +L W+ ++ +
Sbjct: 1525 --SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE------------DLCSWVGQAERAL 1570
Query: 1150 KSQ--RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--KNKTS-NQEART 1204
R DL + + K D++ R ++ + +N+T + T
Sbjct: 1571 AGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELT 1630
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES--- 1261
+ +++ + + Q++ +QE + +++L E + + Q K +A + L + + K+++
Sbjct: 1631 ALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLD 1690
Query: 1262 W---------------------------------KEGPYTVDAIQKKITETKQLAK---- 1284
W +G V+ +K+ + ++ K
Sbjct: 1691 WVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQ 1750
Query: 1285 DLRQWQTNVDVANDLALKLLRDYSADDT-RKVHMITENINASWRSIHKRVSEREAALEET 1343
+L Q N +A A L + + T + M+ + + +++ EA L++
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
Query: 1344 HRL---LQQFPLDLEKFLAWLTEAE-TTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 1399
L LQ+F D ++F +WL +E N+ + + E L L+K+
Sbjct: 1811 QTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETL-------PSLLKRQGSFSE 1863
Query: 1400 EIEAHTDVYHNLDENSQKIL-------RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
++ +H + + QK+L E S+ L++ +L + +++ L K +
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 1923
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRE 1510
SHL Q+ + S L W+Q + + + + D +Q+Q + + E
Sbjct: 1924 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 1983
Query: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
L + P+E L+K+ ++ E+ E + R +++ + + +
Sbjct: 1984 LAEH----------------QVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSH 2025
Query: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEV-IKGSWQPVGDLLIDSLQD 1629
++ L+ A+ + + + + Q +QE+ + L + + E ++G + V L +Q+
Sbjct: 2026 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQVSSLSSGVIQE 2083
Query: 1630 HLEKVKALRGEIAPLKENVSHVNDL 1654
L L+ +IA K ++ ++
Sbjct: 2084 ALATNMKLKQDIARQKSSLEATREM 2108
Score = 67.8 bits (164), Expect = 1e-10
Identities = 156/927 (16%), Positives = 349/927 (37%), Gaps = 160/927 (17%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--- 68
+K RQ LE ++ + + + +L + LT ++ L A D + E K
Sbjct: 4251 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV 4310
Query: 69 IQSDLTSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR------- 115
+++D+ +H+ ++E + K + + A + S+++ + + V K
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4370
Query: 116 -LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
Q+ F +++ + L ++ L A + E + QL+ + LY L +
Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4430
Query: 175 VEMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 233
++ GR ++ + + + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + +
Sbjct: 4431 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490
Query: 234 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 293
+ WL + L S + + + S++ K E+ + + + + G
Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 4550
Query: 294 LKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 352
LK + K++ L+++ L + S W V R+ I
Sbjct: 4551 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------I 4582
Query: 353 QADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
+ LD++ +K+ +Q + K+L L D +DS + ++N D
Sbjct: 4583 ERGRSLDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD--------- 4627
Query: 413 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 472
K + L + ++F + + I+ G LKE+ +
Sbjct: 4628 ------------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 4669
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ + + E+ + D + + + + + E + L S + AL+
Sbjct: 4670 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQAL 4715
Query: 533 HQW-YQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEG 591
W Y+ + Q + D++ + + D K+ +EL K+ + ++R
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRE 4769
Query: 592 LSEDGA--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMP 646
L E+ V+ +LS RW + + ++ RL A Q R+ M++
Sbjct: 4770 LIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE 4829
Query: 647 LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG 706
E + L + T Q+L++ + E + K EE ++ ++
Sbjct: 4830 AEQTLRFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEV 4877
Query: 707 RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 766
+ + H ++ + R + +E L+ W K Q R + ++ +
Sbjct: 4878 ILAVCHPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANA 4926
Query: 767 YDIKIFNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTL 818
++ W+ AE L + IP+N + K ++ +++E+ V +T
Sbjct: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 4986
Query: 819 N----------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLS 856
+ G + + Q + IL + ++ L+ RWQ+V
Sbjct: 4987 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5046
Query: 857 DRKKRLEEQKNILSEFQRDLN-EFVLW 882
+R+++L + + L E + N +F +W
Sbjct: 5047 ERQRKLNDALDRLEELKEFANFDFDVW 5073
Score = 60.5 bits (145), Expect = 2e-08
Identities = 187/989 (18%), Positives = 373/989 (37%), Gaps = 189/989 (19%)
Query: 745 NKMYKDRQGRFDRSVEK----WRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKW 799
NK + R ++S +K W + H + K W +LRK + + W K +
Sbjct: 926 NKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW-----NYLRKDLDLVQTWNLEKLR- 979
Query: 800 YLKELQDGIGQRQTVVRTLNATGEEIIQQS------SKTDASILQEKLGSLNLRWQEVCK 853
G+ +++ L A E+ +Q S S D L+E++ + R+Q + K
Sbjct: 980 -----SSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMK 1034
Query: 854 QLSDRKKR-------LEEQKNI---LSEFQRDLNEFV-----------LWLEEADNIASI 892
+ + K + E KNI L E+++ + + + W + A IA
Sbjct: 1035 SMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQ 1094
Query: 893 PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS-APISPEEQDKLE--- 948
QQL+ L+ V + + + + + + P L S + E+ D +
Sbjct: 1095 EHTQEDLQQLRSDLDAVSMKCDSF-----LHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149
Query: 949 ----NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED---LEEQLNHLLLWLS 1001
NKLK ++ + R++ + + ++ L Q E L D LE + L WLS
Sbjct: 1150 TVYLNKLKTVDV----IVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLS 1205
Query: 1002 PIRNQLEIYNQPNQE---GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRK 1058
++++ +++ ++E ++ + D+E KG L + V +
Sbjct: 1206 DVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER---WHRVIAQ 1262
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
LE SE +++ +L + RA L + T Q ++ A +
Sbjct: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPGQAEDSRVLS 1313
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
L + A+ R T+ LDQ K + ++D ++ KA ++ ++
Sbjct: 1314 EQLSQQTALFAEIERNQTK-------LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQK 1366
Query: 1179 RRPQLEELITAAQNLKNKTSNQEAR-----TIITDRIERIQN---QWDEVQEHLQNRRQQ 1230
+ +++++ + + + R T+ T ++ I + + +E ++ ++ +Q+
Sbjct: 1367 SPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQE 1426
Query: 1231 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1290
E +K+ W+ Q +A KE I+K I E + L+++L +
Sbjct: 1427 HVEKVKELLGWVSTLARNT----QGKATSSETKES----TDIEKAILEQQVLSEELTTKK 1478
Query: 1291 TNVDVANDLALKLLRDYSAD-DTRKVHMITENINASWRSIHK---------RVSEREAAL 1340
V A + L + ++ I+E +NA ++ H + + + A
Sbjct: 1479 EQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAH 1538
Query: 1341 EETHRLLQQ----FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1396
+ + LQ+ LE +W+ +AE Q T ++ L K +L +D
Sbjct: 1539 QTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL----KD 1594
Query: 1397 LQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSELRKKSLNIR 1453
LQ +I+ N + +++ +EG + L R L + LR+K +
Sbjct: 1595 LQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TALREKLHQAK 1640
Query: 1454 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1513
EA ++ + L+E + A+Q++ + +A K +
Sbjct: 1641 EQYEALQEETRVAQKELEEAVT-------------------SALQQETEKSKAAKELAEN 1681
Query: 1514 KEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQEPRELPPEER 1552
K+ + + S + LT P G+E+L Y + P E+
Sbjct: 1682 KKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMGVNQAP--EK 1737
Query: 1553 AQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEATDEL----D 1603
+++ + +E+ ++ + L + Q +D+ T E Q LQ+ EL
Sbjct: 1738 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYS 1797
Query: 1604 LKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1632
L Q+E Q + D L LQDH E
Sbjct: 1798 TSLAQSEAELKQVQTLQDELQKFLQDHKE 1826
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 247 bits (630), Expect = 1e-64
Identities = 345/1755 (19%), Positives = 729/1755 (41%), Gaps = 165/1755 (9%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEAQKIQSDLTS 75
KLL+++ ++ E ++ ++E + + + + A++ + +Q P E + I L
Sbjct: 3207 KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNM 3266
Query: 76 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 123
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3267 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3326
Query: 124 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 169
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3327 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3386
Query: 170 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 229
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3387 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3446
Query: 230 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 289
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3506
Query: 290 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 348
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3507 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3566
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3567 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624
Query: 409 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 456
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684
Query: 457 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 506
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 566
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3804
Query: 567 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 626
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3805 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860
Query: 627 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3861 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3915
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3974
Query: 747 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 804
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031
Query: 805 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 857
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4091
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4092 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4151
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 974
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4152 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4207
Query: 975 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4208 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4263
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4264 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4307
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4308 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4345
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4346 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4404
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4405 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4464
Query: 1272 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 1331
++++ ++ + ++L + N+ W S+
Sbjct: 4465 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4524
Query: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 1391
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4525 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4578
Query: 1392 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 1451
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4579 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4637
Query: 1452 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 1511
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4638 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4697
Query: 1512 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 1571
K V +T T R L + + L E+ +W
Sbjct: 4698 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4738
Query: 1572 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 1630
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4739 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4796
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 1683
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856
Query: 1684 QVAVEDRVRQLHEAH 1698
Q +E +RQ E H
Sbjct: 4857 QTRLEAALRQAEEFH 4871
Score = 217 bits (553), Expect = 9e-56
Identities = 319/1711 (18%), Positives = 674/1711 (39%), Gaps = 190/1711 (11%)
Query: 12 KKAVRRQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 65
KK +R L++++ Q A E+ S + E L K +A KV AQ+ QE
Sbjct: 3321 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QE 3377
Query: 66 AQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 125
+ +Q L + ++E +K+ + ++ + K+L + ++ A
Sbjct: 3378 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRN 3436
Query: 126 RLQESKMI--------LDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEV--- 171
R E + L+ + L +E + V E + +Q L + +K+L +
Sbjct: 3437 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3496
Query: 172 -KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
+ + G+ + E+ + ++ ++ Y E+ K R + L++ L ++
Sbjct: 3497 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3556
Query: 231 KMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 290
++ L WL +L+K S + L + + + Q++I +K ++
Sbjct: 3557 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3616
Query: 291 G-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 349
G E LK G + +++DKL + + + +T + + L + + + +
Sbjct: 3617 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3676
Query: 350 WI--IQADTLLDESEKKKPQQKEDVL---KRLKAELNDIRPKVDSTRDQAANLMANRGDH 404
W+ ++ + L E++ K ++ K LK E + + +DS + ++ L+
Sbjct: 3677 WLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3736
Query: 405 CRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQFNSDI-----------QKLLE 451
R+ +E ++E N R+ +S I K + + +QF+ +KL+
Sbjct: 3737 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3796
Query: 452 PLEAEIQQGVNLKEEDFNKDMNED---NEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 508
+ ++Q + K + ++ + +L++ G + ++E K + +K K
Sbjct: 3797 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLD 3855
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP------ 562
+ ++ + + S+R + Q+ ++L L + + ++ LP P
Sbjct: 3856 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3915
Query: 563 -----RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 617
+ R+++E+ E + +++N Q LS G +++ + + +I+
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE 3974
Query: 618 KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 677
++ A + + T D LE L + +S + ++++ ++
Sbjct: 3975 ---DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031
Query: 678 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 737
+ D E L E+LK + + SG D S K +Q+ L Q+
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQM 4078
Query: 738 DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-------- 789
F WE ++ + ++R+ + +E +F D + + + F+R + P
Sbjct: 4079 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4138
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 849
+ E A+ ++E DG+ + +V L G E+I + D I+++ + LN W
Sbjct: 4139 QQQEAAET---IREEIDGLQEELDIVINL---GSELIAACGEPDKPIVKKSIDELNSAWD 4192
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQ 908
+ K DR +LEE ++Q L W++ A +AS+ + +K+++E+
Sbjct: 4193 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4252
Query: 909 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALP 966
+K E +Q +++LN +L EE DK +++ L + L W + +
Sbjct: 4253 LKQFKSEAYQQQIEMERLNHQAELLLKKVT---EESDKHTVQDPLMELKLIWDSLEERII 4309
Query: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
+Q ++E + LGQ + L++L L WL+ L Q G E E+
Sbjct: 4310 NRQHKLEGALLALGQFQHALDEL-------LAWLTHTEGLLS--EQKPVGGDPKAIEIEL 4360
Query: 1027 A--------VQAKQPDVEEILSKGQHLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQEL 1076
A V A Q VE + G L + + ++ KLE L+ W+ V
Sbjct: 4361 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV------- 4413
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
++T K ++ +L F+
Sbjct: 4414 ------------------------------LEKTEQRKQQLDGALR----QAKGFHGEIE 4439
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
+L WL+ ++ + + + + G E E + E + + L+ Q + +
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4499
Query: 1197 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 1256
+ A T I I ++ +W+ V+ L R+ +L E L + ++ + ++ L QA
Sbjct: 4500 CP-KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4558
Query: 1257 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
L +D + +I E K A ++ + + + L D +
Sbjct: 4559 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4618
Query: 1317 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 1376
+ ++ + W + +R+ ER +L++ + +QF K + WL E+E + +
Sbjct: 4619 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD------S 4672
Query: 1377 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 1436
+ + D +K + Q ++ Q + A VY + + + +DD + L L
Sbjct: 4673 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4732
Query: 1437 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 1496
+ KW + KS+ ++ LE + + +LQ L+ WL + +L+ P+ GD
Sbjct: 4733 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL 4792
Query: 1497 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 1556
V D H+AF++EL + ++ L + REL E +++
Sbjct: 4793 VMNLIDNHKAFQKELGKRT-------------------SSVQALKRSARELI--EGSRDD 4831
Query: 1557 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 1616
+ ++ Q +E++T WE + S Q +++ L + +E L L +AE
Sbjct: 4832 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4891
Query: 1617 QPVGD------LLIDSLQDHLEKVKALRGEI 1641
+ D LID ++ ++K++ R E+
Sbjct: 4892 GVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4922
Score = 213 bits (541), Expect = 2e-54
Identities = 318/1675 (18%), Positives = 668/1675 (39%), Gaps = 181/1675 (10%)
Query: 12 KKAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK-- 68
+K+ R +LL+Q++ +A+ E + L+ DK + D Q+++
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3598
Query: 69 IQSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN----- 122
+Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3599 LQEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656
Query: 123 FEQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 172
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K
Sbjct: 3657 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNK 3716
Query: 173 SEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM 232
+ ++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3717 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3776
Query: 233 RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 292
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3777 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3836
Query: 293 ALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3837 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3896
Query: 352 IQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3897 TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3956
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ-- 459
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3957 S----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012
Query: 460 ---GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQ 507
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4013 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 508 QLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR- 563
L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4132
Query: 564 DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFA 620
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4133 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4192
Query: 621 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 680
+ +I + EE M + Y + V + L +
Sbjct: 4193 SLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPI 4239
Query: 681 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDF 739
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4240 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4300 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEI 4358
Query: 800 YLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS 856
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418
Query: 857 DRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVE 914
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCA 4477
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIE 973
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4478 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLE 4534
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---A 1027
+ + L+D + WL+ L + ++P+ F + E ++
Sbjct: 4535 EALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4587
Query: 1028 VQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLA 1084
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4588 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------- 4640
Query: 1085 PGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL 1144
SL F+ AW++L +WL
Sbjct: 4641 -----------------------------------SLDDARKRAKQFHEAWSKLMEWLEE 4665
Query: 1145 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 1204
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4666 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL 4725
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 1264
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4726 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4785
Query: 1265 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4786 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELST 4844
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLL 1381
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4845 RWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL 4904
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
D KE MK+ ++ + E+ T + + ++ D ++ + + +
Sbjct: 4905 IDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRAR 4954
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQK 1499
+ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014
Query: 1500 QNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQ 1542
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5015 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYP 5074
Query: 1543 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5075 SGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5121
Score = 206 bits (525), Expect = 2e-52
Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 78
K L Q + E S E++T K+ + Q +E I L S
Sbjct: 2980 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3039
Query: 79 SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 124
S + + +++ Q + Q+D+A++ QD+ ++ + Q+ +
Sbjct: 3040 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3099
Query: 125 QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q++ E L+ E L ++ + E +Q Q
Sbjct: 3100 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3159
Query: 164 LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 222
K L + + + KT + ++ ++T + + + AL N+L + R++Q+
Sbjct: 3160 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3219
Query: 223 EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 281
E +K + ++ + L + + V ++ ++ K QK EIE +
Sbjct: 3220 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3279
Query: 282 VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 339
+ + +G+ L K + +E L +N+ W + + + L E H
Sbjct: 3280 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3339
Query: 340 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 399
F ++ + W++ + L+ + +K P + V+K E ++ +D R ++
Sbjct: 3340 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3396
Query: 400 NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 451
G+ EP Q+S L+ R+ A+ ++ +T ++LE + Q+ E
Sbjct: 3397 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3451
Query: 452 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 509
LE + +++ N + ++E + + L+ I + K + + I Q L
Sbjct: 3452 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3511
Query: 510 LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 568
KD+ + L+ S WY + + ++ + L E DE ++
Sbjct: 3512 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3565
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
E+ K +L+ EGL + + + V I L K + ++ LN
Sbjct: 3566 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3618
Query: 629 QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 681
++ T +E +++ + ++ Y T L T++ + L++ + L++ +LC
Sbjct: 3619 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3678
Query: 682 -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+E + K EE+ K +K + + +D ++ +A L+ R
Sbjct: 3679 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3738
Query: 728 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 785
L++ +++ + ++ V+ + D ++ + ++F W+TE E+ L
Sbjct: 3739 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3798
Query: 786 -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
++ ++ A+ + K I + + ++ L +G +I+ S+ + +++KL +
Sbjct: 3799 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3857
Query: 845 NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 903
+ +C+ S+R +LE ++++++F E WL E +I S +P + + L+
Sbjct: 3858 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3917
Query: 904 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 963
++ E+ + L E + + + ++N+TG +L +SP E ++ K + + ++
Sbjct: 3918 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3974
Query: 964 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1022
+ ++ ++ I Q K++ + E L ++ L P E+ + +E + +
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4032
Query: 1023 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1076
+ ++ QP E + +G+ + T + V+ KL+ + W+ ++ L++E
Sbjct: 4033 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4092
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
AK +L+V LA+ + W
Sbjct: 4093 EAK------------------------------------------LLDVMELAE--KFW- 4107
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1193
D +SL+ IK + + DLED I+ ++K Q+ + + + L+E + NL
Sbjct: 4108 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4164
Query: 1194 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1250
++ + + I+ I+ + + WD + + ++R +L E ++ + Q+ + +
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4224
Query: 1251 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1310
+ A KL S ++ ++++I E KQ + Q Q ++ N A LL+ + +
Sbjct: 4225 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4284
Query: 1311 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1369
D V + W S+ +R+ R+ LE L QF L++ LAWLT E
Sbjct: 4285 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4342
Query: 1370 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1429
+ ++ + D K ++ + + LQ ++ AH +++ ++ S G ++A
Sbjct: 4343 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4397
Query: 1430 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1489
LQ +L+ +N +W + +K+ + L+ + Q K H +++L WL + L P
Sbjct: 4398 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4457
Query: 1490 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1549
+GG ++Q +VH + KE S ++ + L P + Q+ L
Sbjct: 4458 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4515
Query: 1550 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1609
+WE + + + K++E L E + + L QA
Sbjct: 4516 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4557
Query: 1610 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1668
E + + +P L++D++ +++ K E+ +E + ++ L +
Sbjct: 4558 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4615
Query: 1669 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1699
+ + L + +RW+ + + +R R L +A +
Sbjct: 4616 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4647
Score = 198 bits (503), Expect = 6e-50
Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 77
++Q+I + + + L + + L+ +D +L++ +A M Q+ AQK++ ++ +
Sbjct: 2674 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2733
Query: 78 ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 122
+ EE K ++ + S DV QK V
Sbjct: 2734 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2793
Query: 123 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 182
F+Q ++ + LD K S + +V++S + + K+L+ E I G
Sbjct: 2794 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2853
Query: 183 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 242
++ K Q L ++ +K +++ +V ER+ +L++ L+ + K ++++ L W
Sbjct: 2854 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2913
Query: 243 LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 301
+ L + + ++ P+ ++ +A K+ QKE+++ ++ + +L +V
Sbjct: 2914 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2971
Query: 302 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 361
+ +V D+ L VT + L + + F + + + A LD
Sbjct: 2972 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3031
Query: 362 EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 416
+ Q + +L+ + L ++ +VD + A +L+ D V Q+ +
Sbjct: 3032 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3091
Query: 417 NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
+ +S ++ K L+ + F + I+++ + ++ + + +
Sbjct: 3092 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3151
Query: 475 DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 520
+ T+K L++ DN + T+E + + IK+ L L + N L D
Sbjct: 3152 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3210
Query: 521 RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 568
R+Q R++ +E + ++Y ++ LL+ ++ E+ + ++ + + K+
Sbjct: 3211 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3270
Query: 569 -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 622
KE LQ K++++N + +GL + A +E ++ RW+ + K AQ
Sbjct: 3271 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3327
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+L A +H R + + + +++ E+L+ +
Sbjct: 3328 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3366
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
+F+ + Q + K ++ L +++I + +A P ++VK+ + LS LD +WE
Sbjct: 3367 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3426
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 801
+ + R + + ++FH ++ N+WLT E+ L + P + +K + +
Sbjct: 3427 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3485
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+D I + + G+ + SS+ D ++Q KL + + E+ ++ R
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
+ L++ F D E + WL E D ++ + ++ + L ++ ++++L E++ L
Sbjct: 3546 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3605
Query: 919 R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 963
R Q +L L TG VL+ + ++ KL + +T Q ++++R
Sbjct: 3606 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3665
Query: 964 ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 996
L E+ E Q+ K+L + K + L + LN +
Sbjct: 3666 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3725
Query: 997 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1051
LL L P R LE + E V +T + K +++ + + Q + A
Sbjct: 3726 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3782
Query: 1052 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1090
T+ L D+ E + LQ + + D+ L T
Sbjct: 3783 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3842
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1147
Q++ V+ I ++ L LE A + N+ W EL WL+
Sbjct: 3843 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3901
Query: 1148 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
+I + E + + + + + + + +P ++++ L + + I
Sbjct: 3902 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3959
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1266
++ + +++E ++ R L+E + STQ+ ++ +Q+L +E ++ P
Sbjct: 3960 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4016
Query: 1267 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1323
V+ I+++I+E K ++ D+ + Q + +++ R D + + ++
Sbjct: 4017 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4076
Query: 1324 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
W +IH V EREA L + L ++F D + + + + L+D +
Sbjct: 4077 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4136
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
++ + E ++ +++ G ++ D+ NL L + G D ++++ +D +N
Sbjct: 4137 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4189
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
W L K + LE + + LQ + W+ + +L+ +PIG D V++Q
Sbjct: 4190 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4249
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
+ + FK E +Q +E +E+L + L + ++ +
Sbjct: 4250 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4290
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
+ E+ W+ L + Q K++ L L + Q A DEL L E + +PVG
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1679
+++ L K L+ ++ + V VN L NL + LE LN R
Sbjct: 4351 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4409
Query: 1680 WKLLQVAVEDRVRQLHEAHR 1699
W+ + E R +QL A R
Sbjct: 4410 WQNVLEKTEQRKQQLDGALR 4429
Score = 191 bits (486), Expect = 6e-48
Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)
Query: 33 KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 88
++L +E++ K+L A +A +A +M ++ DL + LE + K N+
Sbjct: 3148 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3207
Query: 89 GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 148
+ AQ Q++ K+L++ F +L+E ++L + + H +
Sbjct: 3208 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3254
Query: 149 VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 206
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3255 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3314
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
+ L KV +R QL++ L + + + L W+ T+ + + + ++
Sbjct: 3315 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3374
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 325
+ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++AE
Sbjct: 3375 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3434
Query: 326 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 383
L + F + ++ + +W+ + L E Q E+ + + KA +DI
Sbjct: 3435 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3494
Query: 384 RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 438
Q+ ++++R D + +V+ ++ F+ + + I+ + S E
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3546
Query: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 496
L Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3600
Query: 497 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 556
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K L
Sbjct: 3601 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 557 ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 614
+ R++ EL K E+ + + + L + A+ A + +L K +
Sbjct: 3658 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3714
Query: 615 IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3773
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 728
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833
Query: 729 ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 774
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3834 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3893
Query: 775 -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3894 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953
Query: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 890
SI QEK + + + ++ + + R L+E + ++F +++ + LE + +
Sbjct: 3954 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012
Query: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 948
P + +++KE++ + K + ++ Q + + L + G ++ + + ++ ++
Sbjct: 4013 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 949 NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1006
+KL Q W + + E+ EA++ D+ +L +K +H L++ + ++
Sbjct: 4073 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4123
Query: 1007 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1058
+ P + Q+ E A + Q +++ +++ G L +P VK+
Sbjct: 4124 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4183
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
+++L+S W ++N+ ++ I KLE
Sbjct: 4184 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4208
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
+ A + + DW+ + + S + DLE + + I + K + Q
Sbjct: 4209 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262
Query: 1179 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1238
++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4263 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4322
Query: 1239 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1298
Q+ A +E L L K AI+ ++ + L D+ Q+ V+ N
Sbjct: 4323 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4382
Query: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4383 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4442
Query: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
WLT+ E + + L + KE + ++ EA + Y +L + Q++
Sbjct: 4443 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4496
Query: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
L S + + + ++N+ KW + K ++ LE + + H SLQ+ + WL
Sbjct: 4497 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4555
Query: 1479 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1535
+ L+ + V Q D H+ F E+ + I+ +T ++ F +Q +
Sbjct: 4556 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4615
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1585
++ L + + R + V + L RK+A++ + W KL +W +
Sbjct: 4616 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4666
Query: 1586 DETLERLQELQEATDELDLKLRQ 1608
+++L+ E+ D++ +L Q
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQ 4689
Score = 161 bits (407), Expect = 8e-39
Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)
Query: 30 ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 88
ETEK L + + D+ A K ++ + I + S H+I ++ Q
Sbjct: 3789 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3848
Query: 89 G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 146
K+ +VL D + + ++ Q N F + +E L E + + L
Sbjct: 3849 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3908
Query: 147 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 206
++E E ++ Q L + ++E K ++ + KTG Q+++ E + E+ A
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3967
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
Y+++ V +R L++ + S + +++ + E L L + ++ + +
Sbjct: 3968 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4027
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 321
++ K ++EK + +++ + GE + G + V+DKL + W + +
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4087
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 374
EE LL+ + E F DH++ + DT + + P +Q+++ +
Sbjct: 4088 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4145
Query: 375 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 432
++ E++ ++ ++D + + L+A G+ + +V+ I ELN + +++ K K
Sbjct: 4146 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4205
Query: 433 SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 472
++ Q+ +Q + LE ++ +I++ K E + + +
Sbjct: 4206 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4265
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ L + + L +++T+E + ++ L+ ++L++ R+ K
Sbjct: 4266 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4319
Query: 533 HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 584
Q++ D+LL L E L+ + K EI+ ++ + + A
Sbjct: 4320 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4379
Query: 585 VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 635
V + L E A Q +L ++RW+ + K Q ++ L A+ H E
Sbjct: 4380 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4439
Query: 636 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 695
+ +T+ ++ P L E EQL ++CA FE +EE+ K
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4487
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 755
++ QQ R K+A + + ++ L +WE V +R+ +
Sbjct: 4488 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4533
Query: 756 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 809
+ ++ FH ++ F WLT+AEQ L P ++ ++K + E+
Sbjct: 4534 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4590
Query: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869
R+ ++ L+ TG + S K D +++ L S+ RW++V ++L +R + L++ +
Sbjct: 4591 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4649
Query: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 928
+F ++ + WLEE++ LE + ++K +L Q K + L + + N
Sbjct: 4650 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4709
Query: 929 TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 988
TG + ++ ++ KL++ L + +W + E+Q ++E + GQ L+
Sbjct: 4710 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4768
Query: 989 LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1048
L + WL + QL +QP G D+ I D + K L K
Sbjct: 4769 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4810
Query: 1049 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+ Q +KR +L S W V +QEL + +TV ++
Sbjct: 4811 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4853
Query: 1103 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1161
T+ E A+ + E +F+ L +WL+ +Q ++ V+ D +
Sbjct: 4854 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900
Query: 1162 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1215
+ +I + K M+ LE++R +L + T + + T+ + TII R E +
Sbjct: 4901 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4960
Query: 1216 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1256
+ Q+ L + +Q+L E L QW E EE + ++ + +
Sbjct: 4961 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5020
Query: 1257 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1310
+E VD K+T+T K+ A D Q+++ V A Y +
Sbjct: 5021 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5076
Query: 1311 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1359
++ +N + W+ + ER L + L++ F D+ +K++
Sbjct: 5077 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5136
Query: 1360 WLTEAET 1366
W+ ++
Sbjct: 5137 WMNHKKS 5143
Score = 159 bits (402), Expect = 3e-38
Identities = 324/1735 (18%), Positives = 696/1735 (40%), Gaps = 227/1735 (13%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 71
K +QK+ + I + +E + E+L I LA + DK+ + + +++++
Sbjct: 1497 KPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKH-GDKMTDEERNELEKQVKT 1549
Query: 72 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL--- 127
S+ + E K Q + + V + + ++ Q+ K + + E RL
Sbjct: 1550 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1609
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
QE+ MI D + L ++K QE +Q + ++L+EV E +K +
Sbjct: 1610 QEAFMIGDGT-VELKKYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE--- 1659
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
K E+ +++++ K+ +L K + K++L+K + + K TE +AA
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVK 1713
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVE 306
++ +E + + W K+ E+ H + I + G + GK E
Sbjct: 1714 QLEESKTKIENL-------LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE 1766
Query: 307 DKLS--LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-E 360
D+++ LL ++ +E NL +YQK ++ + II A LL+ +
Sbjct: 1767 DEVNGNLLETDVDGQVGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQ 1824
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
+ P++KE + K +K +++ ++ ++ M ++ ++ + + +
Sbjct: 1825 GQYLSPEEKEKLQKNMK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADY 1875
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
H ++ + L+ LE DI L+ L+ +++ F++D+ ++G +
Sbjct: 1876 TEFEHWLQQSEQE--LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDL 1923
Query: 481 KELLQRGDNLQQRITDERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKAL 529
+ + G+ + + KR+ K+ Q+ L + + L S+
Sbjct: 1924 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1983
Query: 530 EISHQWYQYKRQADDLLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKK 579
++ ++ Y+ + LL L E + L EP R + K + ++ ++
Sbjct: 1984 DLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQ 2043
Query: 580 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 639
+ +++ AE L + A ++ P + + K +I ++ + ++ E+ +
Sbjct: 2044 VAVEKLKKTAEVLLD--ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQI 2097
Query: 640 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIK 698
+T + ++ L + +V +L E Q+ LN+ L +D+ + L+
Sbjct: 2098 TLTRSLSVQDGL--DEMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDI 2150
Query: 699 DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRS 758
Q S I+ ++ K +++ P LQ + L ++ + + +K+ + +
Sbjct: 2151 AGRQSS---INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2207
Query: 759 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 818
K F + +L Q L + +P + + Y++E + + + L
Sbjct: 2208 KTKVELFENLSEKLQTFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVL 2266
Query: 819 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE 878
++ +EI +D +++ EK +L+ +++E+ + ++K+ + + L FQ +
Sbjct: 2267 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326
Query: 879 FVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVS 936
W++E I + L + LE K L E+ L+ ++++N +G + L+S
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386
Query: 937 APISPEEQDKL----------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK- 984
A +P + E T W K ++ + +I +DLG L K
Sbjct: 2387 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2446
Query: 985 ----------KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP- 1033
KL+ +E+ + ++ WL + + Q P D + + V+ +
Sbjct: 2447 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSF 2504
Query: 1034 ---------DVEEILSKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQP 1081
V+E+ K L +E P T K+ L ++ S+W+ +N+L + + K
Sbjct: 2505 EAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2564
Query: 1082 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1141
+ + LT Q + Q +V KE +S L
Sbjct: 2565 ESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGP------------------------ 2596
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
LS+ ++ +QR V + +Q+ R+PQ E+L A Q + ++
Sbjct: 2597 LSIDPNMLNTQRQQV-------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDP 2643
Query: 1202 A-RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+ R I+ +++ + +WD + L +R +++ + STQ+ L KL
Sbjct: 2644 SLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS 2703
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKV 1315
S DA+ +++ +++ ++++Q + + VA DL+ + +Y A+ +R++
Sbjct: 2704 SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQL 2763
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
I ++ + V ++A +H+ QQ D F AWL + N +
Sbjct: 2764 EGILKSFKDVEQKAENHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPIS 2819
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
K +LE L+K +D + A + +Y + +L +GS+ A LQ +L
Sbjct: 2820 AKLDVLE------SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQL 2872
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIG 1491
+ + W K+ + L+ S ++ + ++ L W+ + L P
Sbjct: 2873 NTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE 2932
Query: 1492 GD-----FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
G+ ++QK+ D H L ++S E + +T++ ++K+ +
Sbjct: 2933 GENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2992
Query: 1547 LPPEERA-QNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEA 1598
L ++ +N+T+ K+ +EV+ E K L A Q I ++L + L LQ
Sbjct: 2993 LHSKKFCLENMTQKF-KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050
Query: 1599 TDELDLKLRQAEVIKGSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1648
L Q ++ K Q DL++++ D L +V+ + E + L + V
Sbjct: 3051 QKSLQALKHQVDLAKRLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3102
Score = 149 bits (376), Expect = 3e-35
Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)
Query: 47 KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 104
K L+ IA D + + +E + +Q ++S ++++E++KK + +A +L + Q
Sbjct: 2012 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2071
Query: 105 KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 154
K L D+ ++ K N + L S + LDE+ + +E+ EQ V
Sbjct: 2072 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131
Query: 155 -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 209
Q ++ + L + ++ +S + + + ++ ++ L ++ L ++
Sbjct: 2132 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2191
Query: 210 ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
E AK+ E K ++E LS K++ + T+ A T++++ + E +
Sbjct: 2192 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2248
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 322
+ + +K +E LK I+ G L + LV +K + L+ + +
Sbjct: 2249 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2302
Query: 323 AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 369
+E + Q+ ++ F V + W I+Q A+ L E K Q+
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2362
Query: 370 EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 402
+ LK + + L ++ V + T AN+G
Sbjct: 2363 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2422
Query: 403 ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 446
+ L++ +I+ELN + + + + A + L+++ + +
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2482
Query: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Q+ P + E + + + F ++ + N V+EL + L + D + K
Sbjct: 2483 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2541
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 565
+ +K L L R++K E S+ Q++ L + L + E ++ L P D
Sbjct: 2542 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2601
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+ +++Q +E + Q E L+ G + P + + +
Sbjct: 2602 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2651
Query: 626 NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 682
A + T + +++ D ++ + V ST Y + + +S L +++ L++ +
Sbjct: 2652 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2710
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 740
+ + +Q E+ + +K +QQ +I + + + +AL VK + ++L Q
Sbjct: 2711 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2762
Query: 741 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 800
E + K +KD + + + V+ + F Q + + +L + +N H
Sbjct: 2763 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2821
Query: 801 LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 850
L L+ I + +TL A GE ++ ++ ++ + LQ +L ++ W
Sbjct: 2822 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2881
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 907
KQ+ +R+ +L+E +++ + W+++ +N+ I L+P + + KL
Sbjct: 2882 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2940
Query: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 967
K L +E+ G+++ LN T +L I E ENK
Sbjct: 2941 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2980
Query: 968 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1027
L +K++ + EQL+ L + + + + + ++E + ++
Sbjct: 2981 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3022
Query: 1028 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+Q D+ + L + K Q ++ L+ L + RL Q+L + D
Sbjct: 3023 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3077
Query: 1088 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ T V L + + + + +S+ E S L ++ + F E+ +
Sbjct: 3078 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3133
Query: 1146 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1205
D + S + D E + KQK T++ ++ LE L+ + N NKT T
Sbjct: 3134 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3185
Query: 1206 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1257
T +E + Q +++ + Q R +Q+ +K ++ +E +L +A
Sbjct: 3186 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3245
Query: 1258 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1315
ES + I +++ K K+ + Q N L L++ + + T+ +
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
+++NA W++++K+V++R A L+E +F LE L+W+ + E A
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3360
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
+K E K VK +++ + LQ ++ + +KI + E +D +L ++L
Sbjct: 3361 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3418
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1495
++ +W L K+ LE S ++ H +L+ L WL + L PIG
Sbjct: 3419 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3478
Query: 1496 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1550
+++Q H+A + ++ + +S +++++ + + + ++ + + + +
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3538
Query: 1551 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1605
E++ + + LL++ E + +W ++ + L +L +T+ L +L+
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3597
Query: 1606 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1651
+ Q +++ Q V L++ L QD LE +KA +I L +V+
Sbjct: 3598 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656
Query: 1652 NDLARQL 1658
+ A QL
Sbjct: 3657 LEQALQL 3663
Score = 129 bits (324), Expect = 3e-29
Identities = 348/1814 (19%), Positives = 706/1814 (38%), Gaps = 343/1814 (18%)
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDV-SMKFRLFQK 119
++ +E ++++ DL + EE + + S+++V + + V SM K
Sbjct: 1140 KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK 1199
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE--- 176
L+ ++ VK++ ETK E+E V + N+ NL +L + +SEV+
Sbjct: 1200 LKTVNLVLKNTQAAEALVKLY----ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1255
Query: 177 MVIKTGRQIVQKKQ--------TENPKELD-----ERVTALKLHYNELGAKVTERKQQLE 223
V +QK + T ++LD E+ L + + ++ R + LE
Sbjct: 1256 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1315
Query: 224 KCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
K + R + L +W+ +E T+R E P N
Sbjct: 1316 GIGKSLKYYRDTYHPLDDWIQ--QVETTQRKIQENQPEN--------------------- 1352
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ L T L +++ LV + + + S AE++ + +Y+ T+
Sbjct: 1353 -------SKTLATQLNQQKMLVSE-IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1404
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
VD K ++ +++ Q D++ + E D+R + + + GD
Sbjct: 1405 VDSQQKSPVK---------RRRMQSSADLIIQ---EFMDLRTRYTALVTLMTQYIKFAGD 1452
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE-----IQ 458
++L E + S + + KEL+++ S+I K L+ E +
Sbjct: 1453 SLKRLEEEEKSLEEEKKEHVEKA----------KELQKWVSNISKTLKDAEKAGKPPFSK 1502
Query: 459 QGVNLKEEDFNKDMNEDNEGTVKELLQR-GDNLQQRITDERKREEIKIKQQLLQTKHN-- 515
Q ++ +E K+ + T++ L + GD ++TDE +R E++ + + LQ +N
Sbjct: 1503 QKISSEEISTKKEQLSEALQTIQLFLAKHGD----KMTDE-ERNELEKQVKTLQESYNLL 1557
Query: 516 ---ALKDLRSQRRKKALEI-----SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK 567
+LK L+ + +++ + + +YK + + L E +L E
Sbjct: 1558 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAF---M 1614
Query: 568 IKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI--ESKFAQFRRL 625
I + EL+K + + +++ +G S A V+ T+ L + ++ E K ++L
Sbjct: 1615 IGDGTVELKKYQSKQEELQKDMQG-SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1673
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH-------VSQALLEVEQLLNAPD 678
N A+I E + + E E+ V +T + E T + ++ ++E LL+
Sbjct: 1674 NEAKIKC---EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1730
Query: 679 LCAKDFED------------------------LFKQEESLKNI------------KDSLQ 702
KD E + +++E N+ +++L
Sbjct: 1731 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1790
Query: 703 QSSGRIDIIHSKKTA-------ALQSA-----------TPVERVKLQEALSQLDFQWEKV 744
Q ++ H K + A QSA +P E+ KLQ+ + +L +E
Sbjct: 1791 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1850
Query: 745 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE---NWEHAKYKWYL 801
+ + E+ +F D F WL ++EQ L + N K K
Sbjct: 1851 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1910
Query: 802 KELQDGIGQRQTVVRTLNATGEEIIQQS---SKTDASILQEKLGSLNLRWQEVCKQLSDR 858
+D I + + R + +G +++ + SK D + + + Q +DR
Sbjct: 1911 SFSEDVISHKGDL-RYITISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDR 1967
Query: 859 KKRLEEQKNILSEFQRDLNE-----------FVLWLEEADNIAS------IPLEPGKEQQ 901
+ L + N+L +DL + + L+ + AS I ++P +
Sbjct: 1968 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP---KN 2024
Query: 902 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA-----PISPEEQDKLEN------- 949
L+ +LE+ K L ++ +Q +++L +T VL+ A P + Q L++
Sbjct: 2025 LQRQLEETKALQGQISSQQVAVEKLKKTA-EVLLDARGSLLPAKNDIQKTLDDIVGRYED 2083
Query: 950 ----------KLKQTNLQWIKVSRALPEK---QGEIEAQIKDLGQLEKKLEDLEEQLNHL 996
KL+ T + + V L E G +E+ +K+ GQ+ L++ ++
Sbjct: 2084 LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN 2143
Query: 997 LLWLSPIRNQLEIYNQPNQEGPFDVQETE----IAVQAKQPDVEEILSKGQHLYKEKPAT 1052
++ I + N N++ ++ T+ ++QAK D+ S+ H +KE A
Sbjct: 2144 IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA- 2202
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
K+E+L ++ + L ++L+ LT + P + VT ++Q + +
Sbjct: 2203 -----KMEELKTKVELFENLSEKLQTFLETKTQALTEVDV-PGKDVTELSQYMQESTSEF 2256
Query: 1113 SK----LEMPSSLMLEVPA--LADFNRAWTELTDWLSL----LDQVIKSQRVMVGDLE-- 1160
+ LE+ SL+ E+ + L E T+ LS ++ IK ++ V +
Sbjct: 2257 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2316
Query: 1161 -DINEMIIKQ-KATMQDLEQRRPQLEELITA---AQNLKNKTSNQEARTIITDRIERIQN 1215
D ++++K K+ +++ ++ P ++ A ++L++ QE ++ T I+++ N
Sbjct: 2317 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2376
Query: 1216 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL---GQARAKLESWKEGPYTVDAI 1272
+ L + + + A + VL G A E W T +I
Sbjct: 2377 SGISLCN--------LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT--SI 2426
Query: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
+K +T+ +DL LL+D A+ ++ +
Sbjct: 2427 KKDMTDISHGYEDLGL--------------LLKDKIAE------------------LNTK 2454
Query: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
+S+ + A EE+ ++Q WL + TA Q D++ VK ++
Sbjct: 2455 LSKLQKAQEESSAMMQ-----------WLQKMNKTATKWQQTPAPT----DTEAVKTQVE 2499
Query: 1393 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
Q + + E++ + + L + ++L + +A ++ L ++ KW EL + +++
Sbjct: 2500 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2559
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 1512
+ LE SS+ + +L WL K+ +S P+ D + Q + +E
Sbjct: 2560 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2619
Query: 1513 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 1572
T++P EQ + + P E P ++ ++++Q V +W+
Sbjct: 2620 TRKPQY------------EQLTAAGQGILSRPGEDP------SLRGIVKEQLAAVTQKWD 2661
Query: 1573 KLNLHSADWQRKIDETLER-------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
L +D ID+ + + L+ L + +LD KL + + S P D
Sbjct: 2662 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV--STHP------D 2713
Query: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ--LSPYNLSTLEDLNTRWKLL 1683
++ LE + ++ EI K+ + L L+ L + L LE + +K +
Sbjct: 2714 AMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV 2773
Query: 1684 QVAVEDRVRQLHEA 1697
+ E+ V+ L A
Sbjct: 2774 EQKAENHVQHLQSA 2787
Score = 104 bits (260), Expect = 9e-22
Identities = 306/1742 (17%), Positives = 660/1742 (37%), Gaps = 286/1742 (16%)
Query: 97 LSQIDVAQKKLQDVSMKFRLFQKPANFEQ---RLQESKMILDEVKMHLPALETKSVEQEV 153
+ Q++ Q+K+Q+ +P N + +L + KM++ E++M
Sbjct: 1335 IQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMK------------- 1373
Query: 154 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPK----------------EL 197
QS+++ C + S + E+ T R +V +Q K +L
Sbjct: 1374 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1432
Query: 198 DERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEM-NVLTEWLAATDMELTKR 253
R TAL Y + +R ++ EK L+ +K E L +W++ L K
Sbjct: 1433 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL-KD 1491
Query: 254 SAVEGMP----SNLDSEVAWGKATQKEIEKQKVHL-----------KSITEVGEALKTVL 298
+ G P + SE K Q Q + L + E+ + +KT+
Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551
Query: 299 GKKETLVEDKLSLLNSNWIAVTSRAEEWL--NLLLEYQKHME--------TFDQNVDHIT 348
L + L L + + + EE + EY++ ++ T ++ + H
Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1611
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKR-LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
++I T+ E KK Q K++ L++ ++ + V +T + +
Sbjct: 1612 AFMIGDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1667
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIP----------------LKELEQFNSDIQKLLE 451
L+E +++E + ++ + + K + +K+LE+ + I+ LL+
Sbjct: 1668 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1727
Query: 452 PL---------------EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 496
L + Q G + +E D + E++E LL+ + Q T
Sbjct: 1728 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN-GNLLETDVDGQVGTTQ 1786
Query: 497 E---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLK---- 547
E ++ +++K + + + ++H A+ + +Q + LE Q+ + K + +K
Sbjct: 1787 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845
Query: 548 ----CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 603
L + EKK+ ++E +++ D + + + L ++ E L +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEE--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM 1903
Query: 604 TQIQLSKRWRE-IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 662
T+++ K + E + S R + + + + ++ S ++ H
Sbjct: 1904 TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH 1963
Query: 663 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESL---------------------------K 695
+ + N KD D ++ E K
Sbjct: 1964 ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK 2023
Query: 696 NIKDSLQQ--------SSGRIDIIHSKKTA-----ALQSATPVERVKLQEALSQLDFQWE 742
N++ L++ SS ++ + KKTA A S P + +Q+ L + ++E
Sbjct: 2024 NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN-DIQKTLDDIVGRYE 2082
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKWYL 801
++K +R + ++ + + W+ E L++ Q+P N A
Sbjct: 2083 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN-STALQDIIS 2141
Query: 802 KE--LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+ I RQ+ + +N ++ ++ + + AS LQ K+ L+ R+ E + +
Sbjct: 2142 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2201
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVE 914
++EE K + F+ + +LE + PGK+ Q ++E + +
Sbjct: 2202 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2261
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
L + +LK+++ G P DK K NL S+ E + I+
Sbjct: 2262 HLEVLHSLLKEISSHGLP-----------SDKALVLEKTNNL-----SKKFKEMEDTIKE 2305
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN------QEGPFDVQETEIAV 1028
+ + + +++L+ + + L W+ ++ I QP+ + D ++ +
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV-QPSFGAEDLGKSLEDTKKLQEKW 2364
Query: 1029 QAKQPDVEEILSKGQHLYK-------EKPATQPVKRKLEDLSSEWKAVN-------RLLQ 1074
K P+++++ + G L A VK L+ E A N + L
Sbjct: 2365 SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT 2424
Query: 1075 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 1134
++ D++ G +G + + TK + + K + SS M++
Sbjct: 2425 SIKKDMTDISHGYEDLGLLLKDKIAELN----TKLSKLQKAQEESSAMMQ---------- 2470
Query: 1135 WTELTDWLSLLDQVIKS--QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192
WL +++ Q D E + + + K+ +L+Q +++EL
Sbjct: 2471 ------WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2524
Query: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252
L + + + I ++W E+ + +R+Q+L E + TQ+ + + +Q L
Sbjct: 2525 LLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL 2584
Query: 1253 GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD 1310
+ + GP ++D T+ +Q+ L+++ T L A + + +
Sbjct: 2585 VEKELMVSVL--GPLSIDPNMLN-TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE 2641
Query: 1311 DTRKVHMITENINA---SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
D ++ E + A W S+ ++S+R +++ Q+ L L++ +
Sbjct: 2642 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2701
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
++ L +T + + + + +++ ++ Q + +I+ + +L ++ E
Sbjct: 2702 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--- 2758
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLE---ASSDQWKRLHLSLQELLVWLQLKDDE 1483
L R+L+ + + ++ +K+ N HL+ ASS Q++++ Q WL K +E
Sbjct: 2759 ----LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEE 2811
Query: 1484 LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQE 1543
++ PI ++ H+ F + L + + T+ L + +G EK
Sbjct: 2812 QNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEK---- 2865
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL- 1602
L+ Q + T W+ N + + K+ E+LE+ + +E + L
Sbjct: 2866 --------------AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 2911
Query: 1603 ---DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
D E IK P ++ + K+K+L+ E+ V +N+ A L
Sbjct: 2912 PWIDKCQNNLEEIKFCLDPAEG------ENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2965
Query: 1660 TL 1661
++
Sbjct: 2966 SV 2967
Score = 94.7 bits (234), Expect = 9e-19
Identities = 322/1853 (17%), Positives = 708/1853 (38%), Gaps = 350/1853 (18%)
Query: 2 SARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 61
S + L+ + +K + + LL+Q++ E E ++ +Q+ L ++D+
Sbjct: 604 SLQTLKLMQIRKPLLKSSLLDQNLT---EEEINMKFVQDLLNWVDEM------------- 647
Query: 62 MPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA 121
++Q D T L ++ H + + R + +
Sbjct: 648 ------QVQLDRTEWGSDLPSVESHLENHKNVHRAIEE---------------------- 679
Query: 122 NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEM 177
FE L+E+K + E++M P T + + ++SQ LN N + L + + V
Sbjct: 680 -FESSLKEAK--ISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSR 736
Query: 178 VIKTGRQIVQKKQTENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
+ +K++ E + ER T + K ++ EL ++ ++++ ++ +++ ++
Sbjct: 737 ATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL 796
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEV 290
E + R +E + + ++ +W + ++ I++ + + +
Sbjct: 797 ENH-------------PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 843
Query: 291 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 350
EA + K+ ++ K S S+ I + +L+ E + E Q I
Sbjct: 844 KEATDYLRNLKDA-IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANL 896
Query: 351 IIQADTLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
+ +A T++ + KP+ + LK +KA + + ++ +D L N K
Sbjct: 897 MGKAKTII----QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 952
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----L 463
++ P +E + +A +EQ ++ L ++ V+ +
Sbjct: 953 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 1012
Query: 464 KEEDFNKDMNEDNEGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQ 508
E D + N ++K +L Q NLQ R D E +E +++++
Sbjct: 1013 NEID---RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1069
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE- 565
+ K + L+S R++ E + Y + + L C D + +++ + P RD+
Sbjct: 1070 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDL 1128
Query: 566 -------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 618
+ +++ +EL++ K++L + + E AA + PT
Sbjct: 1129 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT-------------- 1174
Query: 619 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLN 675
+R E +V+ ++M ++ + STY+ ++ V+ L E L+
Sbjct: 1175 --------------LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1218
Query: 676 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQ 731
+ + E + + +++N+ +L+Q +D + H+ + ++ + +
Sbjct: 1219 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1278
Query: 732 EALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI-------------------- 771
LDF W K + D+ VE+W+ H I
Sbjct: 1279 YKERDLDFDWHKE---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1329
Query: 772 -FNQWLTEAEQFLRKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNA 820
+ W+ + E RK Q PEN + + K + E+ Q + + Q +A
Sbjct: 1330 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1389
Query: 821 TGEEIIQQSSKTDASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRD 875
T ++ Q+ A + ++ + R + + ++ D + R +++++ +
Sbjct: 1390 TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1449
Query: 876 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 935
+ + LEE E E++ KE +E+ K L + + LK + G P
Sbjct: 1450 AGDSLKRLEEE--------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1501
Query: 936 SAPISPEEQDKLENKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ-------- 981
IS EE + +L + LQ I++ + E++ E+E Q+K L +
Sbjct: 1502 KQKISSEEISTKKEQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1560
Query: 982 ---------------LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 1021
+E+K+ ++ +E+L + L+ N+L + + G V
Sbjct: 1561 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1620
Query: 1022 QETEIAVQAKQPDVEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRA 1078
+ + Q+KQ ++++ + E K +K E LS E KA + + L E +
Sbjct: 1621 ELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1678
Query: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
K L + VT + K A+ +LE S +E L
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NL 1725
Query: 1139 TDWLSLLD-----------QVIKSQ---------RVMVGDLEDINEMIIKQKA------T 1172
DWLS +D QVI+ + +G+ +++N +++ T
Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785
Query: 1173 MQDLEQR----RPQLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQE 1222
++L Q+ + Q E++I+ Q + T + ++ + + + E++Q E++
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845
Query: 1223 HLQN------RRQQLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKK 1275
H + ++ +L L++ + +A E E L Q+ +LE+ + G ++ + K
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1905
Query: 1276 ITETKQLAKDLRQWQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENIN 1323
+ K ++D+ + + + ++ + L+ + S D R+V ++
Sbjct: 1906 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1965
Query: 1324 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 1383
+RS++ + + L++ Q + LA L E TA+ E + D
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVD 2021
Query: 1384 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMN 1439
K ++ +++ + LQG+I + L + ++ +L + L +D +Q+ LD++
Sbjct: 2022 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIV 2078
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ- 1498
++ +L K L+ + + + L E+L W+ + L Q + + A+Q
Sbjct: 2079 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2138
Query: 1499 --------------KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+Q+ ++ ++ K E ST +++ + + E ++
Sbjct: 2139 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2198
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
L E + L +E++ T E + + E Q +QE+T E
Sbjct: 2199 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2258
Query: 1605 KLRQAEVIKGSWQPVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1649
+ EV+ + + L+++ + +K K + I KE V+
Sbjct: 2259 HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2311
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 247 bits (630), Expect = 1e-64
Identities = 345/1755 (19%), Positives = 729/1755 (41%), Gaps = 165/1755 (9%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEAQKIQSDLTS 75
KLL+++ ++ E ++ ++E + + + + A++ + +Q P E + I L
Sbjct: 3218 KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNM 3277
Query: 76 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 123
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
Query: 124 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 169
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
Query: 170 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 229
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
Query: 230 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 289
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
Query: 290 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 348
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
Query: 409 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 456
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
Query: 457 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 506
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 566
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
Query: 567 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 626
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
Query: 627 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
Query: 747 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 804
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
Query: 805 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 857
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 974
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Query: 975 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
Query: 1272 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 1331
++++ ++ + ++L + N+ W S+
Sbjct: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
Query: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 1391
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
Query: 1392 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 1451
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
Query: 1452 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 1511
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
Query: 1512 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 1571
K V +T T R L + + L E+ +W
Sbjct: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
Query: 1572 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 1630
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 1683
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
Query: 1684 QVAVEDRVRQLHEAH 1698
Q +E +RQ E H
Sbjct: 4868 QTRLEAALRQAEEFH 4882
Score = 217 bits (553), Expect = 9e-56
Identities = 319/1711 (18%), Positives = 674/1711 (39%), Gaps = 190/1711 (11%)
Query: 12 KKAVRRQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 65
KK +R L++++ Q A E+ S + E L K +A KV AQ+ QE
Sbjct: 3332 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QE 3388
Query: 66 AQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 125
+ +Q L + ++E +K+ + ++ + K+L + ++ A
Sbjct: 3389 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRN 3447
Query: 126 RLQESKMI--------LDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEV--- 171
R E + L+ + L +E + V E + +Q L + +K+L +
Sbjct: 3448 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3507
Query: 172 -KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
+ + G+ + E+ + ++ ++ Y E+ K R + L++ L ++
Sbjct: 3508 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3567
Query: 231 KMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 290
++ L WL +L+K S + L + + + Q++I +K ++
Sbjct: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627
Query: 291 G-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 349
G E LK G + +++DKL + + + +T + + L + + + +
Sbjct: 3628 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3687
Query: 350 WI--IQADTLLDESEKKKPQQKEDVL---KRLKAELNDIRPKVDSTRDQAANLMANRGDH 404
W+ ++ + L E++ K ++ K LK E + + +DS + ++ L+
Sbjct: 3688 WLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3747
Query: 405 CRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQFNSDI-----------QKLLE 451
R+ +E ++E N R+ +S I K + + +QF+ +KL+
Sbjct: 3748 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3807
Query: 452 PLEAEIQQGVNLKEEDFNKDMNED---NEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 508
+ ++Q + K + ++ + +L++ G + ++E K + +K K
Sbjct: 3808 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLD 3866
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP------ 562
+ ++ + + S+R + Q+ ++L L + + ++ LP P
Sbjct: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
Query: 563 -----RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 617
+ R+++E+ E + +++N Q LS G +++ + + +I+
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE 3985
Query: 618 KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 677
++ A + + T D LE L + +S + ++++ ++
Sbjct: 3986 ---DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
Query: 678 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 737
+ D E L E+LK + + SG D S K +Q+ L Q+
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQM 4089
Query: 738 DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-------- 789
F WE ++ + ++R+ + +E +F D + + + F+R + P
Sbjct: 4090 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4149
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 849
+ E A+ ++E DG+ + +V L G E+I + D I+++ + LN W
Sbjct: 4150 QQQEAAET---IREEIDGLQEELDIVINL---GSELIAACGEPDKPIVKKSIDELNSAWD 4203
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQ 908
+ K DR +LEE ++Q L W++ A +AS+ + +K+++E+
Sbjct: 4204 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263
Query: 909 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALP 966
+K E +Q +++LN +L EE DK +++ L + L W + +
Sbjct: 4264 LKQFKSEAYQQQIEMERLNHQAELLLKKVT---EESDKHTVQDPLMELKLIWDSLEERII 4320
Query: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
+Q ++E + LGQ + L++L L WL+ L Q G E E+
Sbjct: 4321 NRQHKLEGALLALGQFQHALDEL-------LAWLTHTEGLLS--EQKPVGGDPKAIEIEL 4371
Query: 1027 A--------VQAKQPDVEEILSKGQHLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQEL 1076
A V A Q VE + G L + + ++ KLE L+ W+ V
Sbjct: 4372 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV------- 4424
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
++T K ++ +L F+
Sbjct: 4425 ------------------------------LEKTEQRKQQLDGALR----QAKGFHGEIE 4450
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
+L WL+ ++ + + + + G E E + E + + L+ Q + +
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4510
Query: 1197 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 1256
+ A T I I ++ +W+ V+ L R+ +L E L + ++ + ++ L QA
Sbjct: 4511 CP-KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569
Query: 1257 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
L +D + +I E K A ++ + + + L D +
Sbjct: 4570 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4629
Query: 1317 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 1376
+ ++ + W + +R+ ER +L++ + +QF K + WL E+E + +
Sbjct: 4630 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD------S 4683
Query: 1377 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 1436
+ + D +K + Q ++ Q + A VY + + + +DD + L L
Sbjct: 4684 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4743
Query: 1437 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 1496
+ KW + KS+ ++ LE + + +LQ L+ WL + +L+ P+ GD
Sbjct: 4744 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL 4803
Query: 1497 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 1556
V D H+AF++EL + ++ L + REL E +++
Sbjct: 4804 VMNLIDNHKAFQKELGKRT-------------------SSVQALKRSARELI--EGSRDD 4842
Query: 1557 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 1616
+ ++ Q +E++T WE + S Q +++ L + +E L L +AE
Sbjct: 4843 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4902
Query: 1617 QPVGD------LLIDSLQDHLEKVKALRGEI 1641
+ D LID ++ ++K++ R E+
Sbjct: 4903 GVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4933
Score = 213 bits (541), Expect = 2e-54
Identities = 318/1675 (18%), Positives = 668/1675 (39%), Gaps = 181/1675 (10%)
Query: 12 KKAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK-- 68
+K+ R +LL+Q++ +A+ E + L+ DK + D Q+++
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3609
Query: 69 IQSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN----- 122
+Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3610 LQEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667
Query: 123 FEQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 172
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K
Sbjct: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNK 3727
Query: 173 SEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM 232
+ ++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
Query: 233 RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 292
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
Query: 293 ALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
Query: 352 IQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3908 TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3967
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ-- 459
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3968 S----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023
Query: 460 ---GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQ 507
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 508 QLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR- 563
L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
Query: 564 DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFA 620
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
Query: 621 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 680
+ +I + EE M + Y + V + L +
Sbjct: 4204 SLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPI 4250
Query: 681 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDF 739
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4311 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEI 4369
Query: 800 YLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS 856
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
Query: 857 DRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVE 914
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCA 4488
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIE 973
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4489 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLE 4545
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---A 1027
+ + L+D + WL+ L + ++P+ F + E ++
Sbjct: 4546 EALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4598
Query: 1028 VQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLA 1084
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4599 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------- 4651
Query: 1085 PGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL 1144
SL F+ AW++L +WL
Sbjct: 4652 -----------------------------------SLDDARKRAKQFHEAWSKLMEWLEE 4676
Query: 1145 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 1204
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4677 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL 4736
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 1264
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4737 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4796
Query: 1265 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4797 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELST 4855
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLL 1381
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4856 RWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL 4915
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
D KE MK+ ++ + E+ T + + ++ D ++ + + +
Sbjct: 4916 IDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRAR 4965
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQK 1499
+ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
Query: 1500 QNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQ 1542
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYP 5085
Query: 1543 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5086 SGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
Score = 206 bits (525), Expect = 2e-52
Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 78
K L Q + E S E++T K+ + Q +E I L S
Sbjct: 2991 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3050
Query: 79 SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 124
S + + +++ Q + Q+D+A++ QD+ ++ + Q+ +
Sbjct: 3051 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3110
Query: 125 QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q++ E L+ E L ++ + E +Q Q
Sbjct: 3111 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3170
Query: 164 LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 222
K L + + + KT + ++ ++T + + + AL N+L + R++Q+
Sbjct: 3171 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230
Query: 223 EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 281
E +K + ++ + L + + V ++ ++ K QK EIE +
Sbjct: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3290
Query: 282 VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 339
+ + +G+ L K + +E L +N+ W + + + L E H
Sbjct: 3291 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3350
Query: 340 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 399
F ++ + W++ + L+ + +K P + V+K E ++ +D R ++
Sbjct: 3351 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3407
Query: 400 NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 451
G+ EP Q+S L+ R+ A+ ++ +T ++LE + Q+ E
Sbjct: 3408 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3462
Query: 452 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 509
LE + +++ N + ++E + + L+ I + K + + I Q L
Sbjct: 3463 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3522
Query: 510 LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 568
KD+ + L+ S WY + + ++ + L E DE ++
Sbjct: 3523 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3576
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
E+ K +L+ EGL + + + V I L K + ++ LN
Sbjct: 3577 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3629
Query: 629 QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 681
++ T +E +++ + ++ Y T L T++ + L++ + L++ +LC
Sbjct: 3630 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3689
Query: 682 -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+E + K EE+ K +K + + +D ++ +A L+ R
Sbjct: 3690 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3749
Query: 728 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 785
L++ +++ + ++ V+ + D ++ + ++F W+TE E+ L
Sbjct: 3750 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3809
Query: 786 -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
++ ++ A+ + K I + + ++ L +G +I+ S+ + +++KL +
Sbjct: 3810 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3868
Query: 845 NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 903
+ +C+ S+R +LE ++++++F E WL E +I S +P + + L+
Sbjct: 3869 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3928
Query: 904 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 963
++ E+ + L E + + + ++N+TG +L +SP E ++ K + + ++
Sbjct: 3929 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3985
Query: 964 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1022
+ ++ ++ I Q K++ + E L ++ L P E+ + +E + +
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4043
Query: 1023 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1076
+ ++ QP E + +G+ + T + V+ KL+ + W+ ++ L++E
Sbjct: 4044 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4103
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
AK +L+V LA+ + W
Sbjct: 4104 EAK------------------------------------------LLDVMELAE--KFW- 4118
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1193
D +SL+ IK + + DLED I+ ++K Q+ + + + L+E + NL
Sbjct: 4119 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4175
Query: 1194 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1250
++ + + I+ I+ + + WD + + ++R +L E ++ + Q+ + +
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4235
Query: 1251 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1310
+ A KL S ++ ++++I E KQ + Q Q ++ N A LL+ + +
Sbjct: 4236 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295
Query: 1311 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1369
D V + W S+ +R+ R+ LE L QF L++ LAWLT E
Sbjct: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4353
Query: 1370 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1429
+ ++ + D K ++ + + LQ ++ AH +++ ++ S G ++A
Sbjct: 4354 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4408
Query: 1430 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1489
LQ +L+ +N +W + +K+ + L+ + Q K H +++L WL + L P
Sbjct: 4409 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4468
Query: 1490 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1549
+GG ++Q +VH + KE S ++ + L P + Q+ L
Sbjct: 4469 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4526
Query: 1550 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1609
+WE + + + K++E L E + + L QA
Sbjct: 4527 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4568
Query: 1610 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1668
E + + +P L++D++ +++ K E+ +E + ++ L +
Sbjct: 4569 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4626
Query: 1669 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1699
+ + L + +RW+ + + +R R L +A +
Sbjct: 4627 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4658
Score = 198 bits (503), Expect = 6e-50
Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 77
++Q+I + + + L + + L+ +D +L++ +A M Q+ AQK++ ++ +
Sbjct: 2685 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2744
Query: 78 ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 122
+ EE K ++ + S DV QK V
Sbjct: 2745 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2804
Query: 123 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 182
F+Q ++ + LD K S + +V++S + + K+L+ E I G
Sbjct: 2805 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2864
Query: 183 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 242
++ K Q L ++ +K +++ +V ER+ +L++ L+ + K ++++ L W
Sbjct: 2865 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
Query: 243 LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 301
+ L + + ++ P+ ++ +A K+ QKE+++ ++ + +L +V
Sbjct: 2925 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
Query: 302 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 361
+ +V D+ L VT + L + + F + + + A LD
Sbjct: 2983 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3042
Query: 362 EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 416
+ Q + +L+ + L ++ +VD + A +L+ D V Q+ +
Sbjct: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3102
Query: 417 NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
+ +S ++ K L+ + F + I+++ + ++ + + +
Sbjct: 3103 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3162
Query: 475 DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 520
+ T+K L++ DN + T+E + + IK+ L L + N L D
Sbjct: 3163 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3221
Query: 521 RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 568
R+Q R++ +E + ++Y ++ LL+ ++ E+ + ++ + + K+
Sbjct: 3222 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3281
Query: 569 -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 622
KE LQ K++++N + +GL + A +E ++ RW+ + K AQ
Sbjct: 3282 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3338
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+L A +H R + + + +++ E+L+ +
Sbjct: 3339 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3377
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
+F+ + Q + K ++ L +++I + +A P ++VK+ + LS LD +WE
Sbjct: 3378 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3437
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 801
+ + R + + ++FH ++ N+WLT E+ L + P + +K + +
Sbjct: 3438 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3496
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+D I + + G+ + SS+ D ++Q KL + + E+ ++ R
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
+ L++ F D E + WL E D ++ + ++ + L ++ ++++L E++ L
Sbjct: 3557 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3616
Query: 919 R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 963
R Q +L L TG VL+ + ++ KL + +T Q ++++R
Sbjct: 3617 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3676
Query: 964 ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 996
L E+ E Q+ K+L + K + L + LN +
Sbjct: 3677 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3736
Query: 997 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1051
LL L P R LE + E V +T + K +++ + + Q + A
Sbjct: 3737 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3793
Query: 1052 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1090
T+ L D+ E + LQ + + D+ L T
Sbjct: 3794 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3853
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1147
Q++ V+ I ++ L LE A + N+ W EL WL+
Sbjct: 3854 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3912
Query: 1148 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
+I + E + + + + + + + +P ++++ L + + I
Sbjct: 3913 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3970
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1266
++ + +++E ++ R L+E + STQ+ ++ +Q+L +E ++ P
Sbjct: 3971 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4027
Query: 1267 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1323
V+ I+++I+E K ++ D+ + Q + +++ R D + + ++
Sbjct: 4028 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4087
Query: 1324 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
W +IH V EREA L + L ++F D + + + + L+D +
Sbjct: 4088 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4147
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
++ + E ++ +++ G ++ D+ NL L + G D ++++ +D +N
Sbjct: 4148 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4200
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
W L K + LE + + LQ + W+ + +L+ +PIG D V++Q
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
+ + FK E +Q +E +E+L + L + ++ +
Sbjct: 4261 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4301
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
+ E+ W+ L + Q K++ L L + Q A DEL L E + +PVG
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1679
+++ L K L+ ++ + V VN L NL + LE LN R
Sbjct: 4362 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420
Query: 1680 WKLLQVAVEDRVRQLHEAHR 1699
W+ + E R +QL A R
Sbjct: 4421 WQNVLEKTEQRKQQLDGALR 4440
Score = 191 bits (486), Expect = 6e-48
Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)
Query: 33 KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 88
++L +E++ K+L A +A +A +M ++ DL + LE + K N+
Sbjct: 3159 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3218
Query: 89 GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 148
+ AQ Q++ K+L++ F +L+E ++L + + H +
Sbjct: 3219 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3265
Query: 149 VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 206
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
+ L KV +R QL++ L + + + L W+ T+ + + + ++
Sbjct: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3385
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 325
+ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++AE
Sbjct: 3386 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3445
Query: 326 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 383
L + F + ++ + +W+ + L E Q E+ + + KA +DI
Sbjct: 3446 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3505
Query: 384 RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 438
Q+ ++++R D + +V+ ++ F+ + + I+ + S E
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3557
Query: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 496
L Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3611
Query: 497 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 556
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K L
Sbjct: 3612 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 557 ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 614
+ R++ EL K E+ + + + L + A+ A + +L K +
Sbjct: 3669 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3725
Query: 615 IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3784
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 728
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844
Query: 729 ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 774
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3845 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3904
Query: 775 -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
Query: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 890
SI QEK + + + ++ + + R L+E + ++F +++ + LE + +
Sbjct: 3965 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023
Query: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 948
P + +++KE++ + K + ++ Q + + L + G ++ + + ++ ++
Sbjct: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 949 NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1006
+KL Q W + + E+ EA++ D+ +L +K +H L++ + ++
Sbjct: 4084 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4134
Query: 1007 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1058
+ P + Q+ E A + Q +++ +++ G L +P VK+
Sbjct: 4135 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4194
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
+++L+S W ++N+ ++ I KLE
Sbjct: 4195 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4219
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
+ A + + DW+ + + S + DLE + + I + K + Q
Sbjct: 4220 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
Query: 1179 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1238
++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333
Query: 1239 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1298
Q+ A +E L L K AI+ ++ + L D+ Q+ V+ N
Sbjct: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393
Query: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4453
Query: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
WLT+ E + + L + KE + ++ EA + Y +L + Q++
Sbjct: 4454 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4507
Query: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
L S + + + ++N+ KW + K ++ LE + + H SLQ+ + WL
Sbjct: 4508 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4566
Query: 1479 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1535
+ L+ + V Q D H+ F E+ + I+ +T ++ F +Q +
Sbjct: 4567 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4626
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1585
++ L + + R + V + L RK+A++ + W KL +W +
Sbjct: 4627 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4677
Query: 1586 DETLERLQELQEATDELDLKLRQ 1608
+++L+ E+ D++ +L Q
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQ 4700
Score = 161 bits (407), Expect = 8e-39
Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)
Query: 30 ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 88
ETEK L + + D+ A K ++ + I + S H+I ++ Q
Sbjct: 3800 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3859
Query: 89 G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 146
K+ +VL D + + ++ Q N F + +E L E + + L
Sbjct: 3860 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919
Query: 147 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 206
++E E ++ Q L + ++E K ++ + KTG Q+++ E + E+ A
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3978
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
Y+++ V +R L++ + S + +++ + E L L + ++ + +
Sbjct: 3979 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 321
++ K ++EK + +++ + GE + G + V+DKL + W + +
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 374
EE LL+ + E F DH++ + DT + + P +Q+++ +
Sbjct: 4099 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
Query: 375 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 432
++ E++ ++ ++D + + L+A G+ + +V+ I ELN + +++ K K
Sbjct: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
Query: 433 SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 472
++ Q+ +Q + LE ++ +I++ K E + + +
Sbjct: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ L + + L +++T+E + ++ L+ ++L++ R+ K
Sbjct: 4277 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4330
Query: 533 HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 584
Q++ D+LL L E L+ + K EI+ ++ + + A
Sbjct: 4331 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4390
Query: 585 VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 635
V + L E A Q +L ++RW+ + K Q ++ L A+ H E
Sbjct: 4391 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4450
Query: 636 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 695
+ +T+ ++ P L E EQL ++CA FE +EE+ K
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4498
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 755
++ QQ R K+A + + ++ L +WE V +R+ +
Sbjct: 4499 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4544
Query: 756 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 809
+ ++ FH ++ F WLT+AEQ L P ++ ++K + E+
Sbjct: 4545 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4601
Query: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869
R+ ++ L+ TG + S K D +++ L S+ RW++V ++L +R + L++ +
Sbjct: 4602 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4660
Query: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 928
+F ++ + WLEE++ LE + ++K +L Q K + L + + N
Sbjct: 4661 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4720
Query: 929 TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 988
TG + ++ ++ KL++ L + +W + E+Q ++E + GQ L+
Sbjct: 4721 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4779
Query: 989 LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1048
L + WL + QL +QP G D+ I D + K L K
Sbjct: 4780 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4821
Query: 1049 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+ Q +KR +L S W V +QEL + +TV ++
Sbjct: 4822 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4864
Query: 1103 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1161
T+ E A+ + E +F+ L +WL+ +Q ++ V+ D +
Sbjct: 4865 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911
Query: 1162 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1215
+ +I + K M+ LE++R +L + T + + T+ + TII R E +
Sbjct: 4912 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4971
Query: 1216 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1256
+ Q+ L + +Q+L E L QW E EE + ++ + +
Sbjct: 4972 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5031
Query: 1257 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1310
+E VD K+T+T K+ A D Q+++ V A Y +
Sbjct: 5032 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Query: 1311 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1359
++ +N + W+ + ER L + L++ F D+ +K++
Sbjct: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5147
Query: 1360 WLTEAET 1366
W+ ++
Sbjct: 5148 WMNHKKS 5154
Score = 159 bits (402), Expect = 3e-38
Identities = 324/1735 (18%), Positives = 696/1735 (40%), Gaps = 227/1735 (13%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 71
K +QK+ + I + +E + E+L I LA + DK+ + + +++++
Sbjct: 1508 KPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKH-GDKMTDEERNELEKQVKT 1560
Query: 72 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL--- 127
S+ + E K Q + + V + + ++ Q+ K + + E RL
Sbjct: 1561 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1620
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
QE+ MI D + L ++K QE +Q + ++L+EV E +K +
Sbjct: 1621 QEAFMIGDGT-VELKKYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE--- 1670
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
K E+ +++++ K+ +L K + K++L+K + + K TE +AA
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVK 1724
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVE 306
++ +E + + W K+ E+ H + I + G + GK E
Sbjct: 1725 QLEESKTKIENL-------LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE 1777
Query: 307 DKLS--LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-E 360
D+++ LL ++ +E NL +YQK ++ + II A LL+ +
Sbjct: 1778 DEVNGNLLETDVDGQVGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQ 1835
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
+ P++KE + K +K +++ ++ ++ M ++ ++ + + +
Sbjct: 1836 GQYLSPEEKEKLQKNMK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADY 1886
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
H ++ + L+ LE DI L+ L+ +++ F++D+ ++G +
Sbjct: 1887 TEFEHWLQQSEQE--LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDL 1934
Query: 481 KELLQRGDNLQQRITDERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKAL 529
+ + G+ + + KR+ K+ Q+ L + + L S+
Sbjct: 1935 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1994
Query: 530 EISHQWYQYKRQADDLLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKK 579
++ ++ Y+ + LL L E + L EP R + K + ++ ++
Sbjct: 1995 DLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQ 2054
Query: 580 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 639
+ +++ AE L + A ++ P + + K +I ++ + ++ E+ +
Sbjct: 2055 VAVEKLKKTAEVLLD--ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQI 2108
Query: 640 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIK 698
+T + ++ L + +V +L E Q+ LN+ L +D+ + L+
Sbjct: 2109 TLTRSLSVQDGL--DEMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDI 2161
Query: 699 DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRS 758
Q S I+ ++ K +++ P LQ + L ++ + + +K+ + +
Sbjct: 2162 AGRQSS---INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2218
Query: 759 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 818
K F + +L Q L + +P + + Y++E + + + L
Sbjct: 2219 KTKVELFENLSEKLQTFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVL 2277
Query: 819 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE 878
++ +EI +D +++ EK +L+ +++E+ + ++K+ + + L FQ +
Sbjct: 2278 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
Query: 879 FVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVS 936
W++E I + L + LE K L E+ L+ ++++N +G + L+S
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
Query: 937 APISPEEQDKL----------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK- 984
A +P + E T W K ++ + +I +DLG L K
Sbjct: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457
Query: 985 ----------KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP- 1033
KL+ +E+ + ++ WL + + Q P D + + V+ +
Sbjct: 2458 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSF 2515
Query: 1034 ---------DVEEILSKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQP 1081
V+E+ K L +E P T K+ L ++ S+W+ +N+L + + K
Sbjct: 2516 EAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2575
Query: 1082 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1141
+ + LT Q + Q +V KE +S L
Sbjct: 2576 ESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGP------------------------ 2607
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
LS+ ++ +QR V + +Q+ R+PQ E+L A Q + ++
Sbjct: 2608 LSIDPNMLNTQRQQV-------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDP 2654
Query: 1202 A-RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+ R I+ +++ + +WD + L +R +++ + STQ+ L KL
Sbjct: 2655 SLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS 2714
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKV 1315
S DA+ +++ +++ ++++Q + + VA DL+ + +Y A+ +R++
Sbjct: 2715 SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQL 2774
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
I ++ + V ++A +H+ QQ D F AWL + N +
Sbjct: 2775 EGILKSFKDVEQKAENHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPIS 2830
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
K +LE L+K +D + A + +Y + +L +GS+ A LQ +L
Sbjct: 2831 AKLDVLE------SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQL 2883
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIG 1491
+ + W K+ + L+ S ++ + ++ L W+ + L P
Sbjct: 2884 NTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE 2943
Query: 1492 GD-----FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
G+ ++QK+ D H L ++S E + +T++ ++K+ +
Sbjct: 2944 GENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 3003
Query: 1547 LPPEERA-QNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEA 1598
L ++ +N+T+ K+ +EV+ E K L A Q I ++L + L LQ
Sbjct: 3004 LHSKKFCLENMTQKF-KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
Query: 1599 TDELDLKLRQAEVIKGSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1648
L Q ++ K Q DL++++ D L +V+ + E + L + V
Sbjct: 3062 QKSLQALKHQVDLAKRLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3113
Score = 149 bits (376), Expect = 3e-35
Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)
Query: 47 KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 104
K L+ IA D + + +E + +Q ++S ++++E++KK + +A +L + Q
Sbjct: 2023 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2082
Query: 105 KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 154
K L D+ ++ K N + L S + LDE+ + +E+ EQ V
Sbjct: 2083 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142
Query: 155 -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 209
Q ++ + L + ++ +S + + + ++ ++ L ++ L ++
Sbjct: 2143 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2202
Query: 210 ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
E AK+ E K ++E LS K++ + T+ A T++++ + E +
Sbjct: 2203 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2259
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 322
+ + +K +E LK I+ G L + LV +K + L+ + +
Sbjct: 2260 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2313
Query: 323 AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 369
+E + Q+ ++ F V + W I+Q A+ L E K Q+
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2373
Query: 370 EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 402
+ LK + + L ++ V + T AN+G
Sbjct: 2374 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2433
Query: 403 ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 446
+ L++ +I+ELN + + + + A + L+++ + +
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493
Query: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Q+ P + E + + + F ++ + N V+EL + L + D + K
Sbjct: 2494 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2552
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 565
+ +K L L R++K E S+ Q++ L + L + E ++ L P D
Sbjct: 2553 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2612
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+ +++Q +E + Q E L+ G + P + + +
Sbjct: 2613 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2662
Query: 626 NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 682
A + T + +++ D ++ + V ST Y + + +S L +++ L++ +
Sbjct: 2663 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2721
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 740
+ + +Q E+ + +K +QQ +I + + + +AL VK + ++L Q
Sbjct: 2722 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2773
Query: 741 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 800
E + K +KD + + + V+ + F Q + + +L + +N H
Sbjct: 2774 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2832
Query: 801 LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 850
L L+ I + +TL A GE ++ ++ ++ + LQ +L ++ W
Sbjct: 2833 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2892
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 907
KQ+ +R+ +L+E +++ + W+++ +N+ I L+P + + KL
Sbjct: 2893 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2951
Query: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 967
K L +E+ G+++ LN T +L I E ENK
Sbjct: 2952 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2991
Query: 968 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1027
L +K++ + EQL+ L + + + + + ++E + ++
Sbjct: 2992 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3033
Query: 1028 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+Q D+ + L + K Q ++ L+ L + RL Q+L + D
Sbjct: 3034 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3088
Query: 1088 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ T V L + + + + +S+ E S L ++ + F E+ +
Sbjct: 3089 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3144
Query: 1146 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1205
D + S + D E + KQK T++ ++ LE L+ + N NKT T
Sbjct: 3145 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3196
Query: 1206 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1257
T +E + Q +++ + Q R +Q+ +K ++ +E +L +A
Sbjct: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3256
Query: 1258 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1315
ES + I +++ K K+ + Q N L L++ + + T+ +
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
+++NA W++++K+V++R A L+E +F LE L+W+ + E A
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3371
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
+K E K VK +++ + LQ ++ + +KI + E +D +L ++L
Sbjct: 3372 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3429
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1495
++ +W L K+ LE S ++ H +L+ L WL + L PIG
Sbjct: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489
Query: 1496 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1550
+++Q H+A + ++ + +S +++++ + + + ++ + + + +
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
Query: 1551 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1605
E++ + + LL++ E + +W ++ + L +L +T+ L +L+
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3608
Query: 1606 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1651
+ Q +++ Q V L++ L QD LE +KA +I L +V+
Sbjct: 3609 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667
Query: 1652 NDLARQL 1658
+ A QL
Sbjct: 3668 LEQALQL 3674
Score = 129 bits (324), Expect = 3e-29
Identities = 348/1814 (19%), Positives = 706/1814 (38%), Gaps = 343/1814 (18%)
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDV-SMKFRLFQK 119
++ +E ++++ DL + EE + + S+++V + + V SM K
Sbjct: 1151 KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK 1210
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE--- 176
L+ ++ VK++ ETK E+E V + N+ NL +L + +SEV+
Sbjct: 1211 LKTVNLVLKNTQAAEALVKLY----ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266
Query: 177 MVIKTGRQIVQKKQ--------TENPKELD-----ERVTALKLHYNELGAKVTERKQQLE 223
V +QK + T ++LD E+ L + + ++ R + LE
Sbjct: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1326
Query: 224 KCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
K + R + L +W+ +E T+R E P N
Sbjct: 1327 GIGKSLKYYRDTYHPLDDWIQ--QVETTQRKIQENQPEN--------------------- 1363
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ L T L +++ LV + + + S AE++ + +Y+ T+
Sbjct: 1364 -------SKTLATQLNQQKMLVSE-IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1415
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
VD K ++ +++ Q D++ + E D+R + + + GD
Sbjct: 1416 VDSQQKSPVK---------RRRMQSSADLIIQ---EFMDLRTRYTALVTLMTQYIKFAGD 1463
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE-----IQ 458
++L E + S + + KEL+++ S+I K L+ E +
Sbjct: 1464 SLKRLEEEEKSLEEEKKEHVEKA----------KELQKWVSNISKTLKDAEKAGKPPFSK 1513
Query: 459 QGVNLKEEDFNKDMNEDNEGTVKELLQR-GDNLQQRITDERKREEIKIKQQLLQTKHN-- 515
Q ++ +E K+ + T++ L + GD ++TDE +R E++ + + LQ +N
Sbjct: 1514 QKISSEEISTKKEQLSEALQTIQLFLAKHGD----KMTDE-ERNELEKQVKTLQESYNLL 1568
Query: 516 ---ALKDLRSQRRKKALEI-----SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK 567
+LK L+ + +++ + + +YK + + L E +L E
Sbjct: 1569 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAF---M 1625
Query: 568 IKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI--ESKFAQFRRL 625
I + EL+K + + +++ +G S A V+ T+ L + ++ E K ++L
Sbjct: 1626 IGDGTVELKKYQSKQEELQKDMQG-SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1684
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH-------VSQALLEVEQLLNAPD 678
N A+I E + + E E+ V +T + E T + ++ ++E LL+
Sbjct: 1685 NEAKIKC---EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1741
Query: 679 LCAKDFED------------------------LFKQEESLKNI------------KDSLQ 702
KD E + +++E N+ +++L
Sbjct: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1801
Query: 703 QSSGRIDIIHSKKTA-------ALQSA-----------TPVERVKLQEALSQLDFQWEKV 744
Q ++ H K + A QSA +P E+ KLQ+ + +L +E
Sbjct: 1802 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1861
Query: 745 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE---NWEHAKYKWYL 801
+ + E+ +F D F WL ++EQ L + N K K
Sbjct: 1862 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1921
Query: 802 KELQDGIGQRQTVVRTLNATGEEIIQQS---SKTDASILQEKLGSLNLRWQEVCKQLSDR 858
+D I + + R + +G +++ + SK D + + + Q +DR
Sbjct: 1922 SFSEDVISHKGDL-RYITISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDR 1978
Query: 859 KKRLEEQKNILSEFQRDLNE-----------FVLWLEEADNIAS------IPLEPGKEQQ 901
+ L + N+L +DL + + L+ + AS I ++P +
Sbjct: 1979 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP---KN 2035
Query: 902 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA-----PISPEEQDKLEN------- 949
L+ +LE+ K L ++ +Q +++L +T VL+ A P + Q L++
Sbjct: 2036 LQRQLEETKALQGQISSQQVAVEKLKKTA-EVLLDARGSLLPAKNDIQKTLDDIVGRYED 2094
Query: 950 ----------KLKQTNLQWIKVSRALPEK---QGEIEAQIKDLGQLEKKLEDLEEQLNHL 996
KL+ T + + V L E G +E+ +K+ GQ+ L++ ++
Sbjct: 2095 LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN 2154
Query: 997 LLWLSPIRNQLEIYNQPNQEGPFDVQETE----IAVQAKQPDVEEILSKGQHLYKEKPAT 1052
++ I + N N++ ++ T+ ++QAK D+ S+ H +KE A
Sbjct: 2155 IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA- 2213
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
K+E+L ++ + L ++L+ LT + P + VT ++Q + +
Sbjct: 2214 -----KMEELKTKVELFENLSEKLQTFLETKTQALTEVDV-PGKDVTELSQYMQESTSEF 2267
Query: 1113 SK----LEMPSSLMLEVPA--LADFNRAWTELTDWLSL----LDQVIKSQRVMVGDLE-- 1160
+ LE+ SL+ E+ + L E T+ LS ++ IK ++ V +
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2327
Query: 1161 -DINEMIIKQ-KATMQDLEQRRPQLEELITA---AQNLKNKTSNQEARTIITDRIERIQN 1215
D ++++K K+ +++ ++ P ++ A ++L++ QE ++ T I+++ N
Sbjct: 2328 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2387
Query: 1216 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL---GQARAKLESWKEGPYTVDAI 1272
+ L + + + A + VL G A E W T +I
Sbjct: 2388 SGISLCN--------LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT--SI 2437
Query: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
+K +T+ +DL LL+D A+ ++ +
Sbjct: 2438 KKDMTDISHGYEDLGL--------------LLKDKIAE------------------LNTK 2465
Query: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
+S+ + A EE+ ++Q WL + TA Q D++ VK ++
Sbjct: 2466 LSKLQKAQEESSAMMQ-----------WLQKMNKTATKWQQTPAPT----DTEAVKTQVE 2510
Query: 1393 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
Q + + E++ + + L + ++L + +A ++ L ++ KW EL + +++
Sbjct: 2511 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2570
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 1512
+ LE SS+ + +L WL K+ +S P+ D + Q + +E
Sbjct: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2630
Query: 1513 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 1572
T++P EQ + + P E P ++ ++++Q V +W+
Sbjct: 2631 TRKPQY------------EQLTAAGQGILSRPGEDP------SLRGIVKEQLAAVTQKWD 2672
Query: 1573 KLNLHSADWQRKIDETLER-------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
L +D ID+ + + L+ L + +LD KL + + S P D
Sbjct: 2673 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV--STHP------D 2724
Query: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ--LSPYNLSTLEDLNTRWKLL 1683
++ LE + ++ EI K+ + L L+ L + L LE + +K +
Sbjct: 2725 AMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV 2784
Query: 1684 QVAVEDRVRQLHEA 1697
+ E+ V+ L A
Sbjct: 2785 EQKAENHVQHLQSA 2798
Score = 104 bits (260), Expect = 9e-22
Identities = 306/1742 (17%), Positives = 660/1742 (37%), Gaps = 286/1742 (16%)
Query: 97 LSQIDVAQKKLQDVSMKFRLFQKPANFEQ---RLQESKMILDEVKMHLPALETKSVEQEV 153
+ Q++ Q+K+Q+ +P N + +L + KM++ E++M
Sbjct: 1346 IQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMK------------- 1384
Query: 154 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPK----------------EL 197
QS+++ C + S + E+ T R +V +Q K +L
Sbjct: 1385 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1443
Query: 198 DERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEM-NVLTEWLAATDMELTKR 253
R TAL Y + +R ++ EK L+ +K E L +W++ L K
Sbjct: 1444 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL-KD 1502
Query: 254 SAVEGMP----SNLDSEVAWGKATQKEIEKQKVHL-----------KSITEVGEALKTVL 298
+ G P + SE K Q Q + L + E+ + +KT+
Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
Query: 299 GKKETLVEDKLSLLNSNWIAVTSRAEEWL--NLLLEYQKHME--------TFDQNVDHIT 348
L + L L + + + EE + EY++ ++ T ++ + H
Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKR-LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
++I T+ E KK Q K++ L++ ++ + V +T + +
Sbjct: 1623 AFMIGDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1678
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIP----------------LKELEQFNSDIQKLLE 451
L+E +++E + ++ + + K + +K+LE+ + I+ LL+
Sbjct: 1679 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1738
Query: 452 PL---------------EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 496
L + Q G + +E D + E++E LL+ + Q T
Sbjct: 1739 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN-GNLLETDVDGQVGTTQ 1797
Query: 497 E---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLK---- 547
E ++ +++K + + + ++H A+ + +Q + LE Q+ + K + +K
Sbjct: 1798 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
Query: 548 ----CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 603
L + EKK+ ++E +++ D + + + L ++ E L +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEE--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM 1914
Query: 604 TQIQLSKRWRE-IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 662
T+++ K + E + S R + + + + ++ S ++ H
Sbjct: 1915 TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH 1974
Query: 663 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESL---------------------------K 695
+ + N KD D ++ E K
Sbjct: 1975 ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK 2034
Query: 696 NIKDSLQQ--------SSGRIDIIHSKKTA-----ALQSATPVERVKLQEALSQLDFQWE 742
N++ L++ SS ++ + KKTA A S P + +Q+ L + ++E
Sbjct: 2035 NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN-DIQKTLDDIVGRYE 2093
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKWYL 801
++K +R + ++ + + W+ E L++ Q+P N A
Sbjct: 2094 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN-STALQDIIS 2152
Query: 802 KE--LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+ I RQ+ + +N ++ ++ + + AS LQ K+ L+ R+ E + +
Sbjct: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVE 914
++EE K + F+ + +LE + PGK+ Q ++E + +
Sbjct: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2272
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
L + +LK+++ G P DK K NL S+ E + I+
Sbjct: 2273 HLEVLHSLLKEISSHGLP-----------SDKALVLEKTNNL-----SKKFKEMEDTIKE 2316
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN------QEGPFDVQETEIAV 1028
+ + + +++L+ + + L W+ ++ I QP+ + D ++ +
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV-QPSFGAEDLGKSLEDTKKLQEKW 2375
Query: 1029 QAKQPDVEEILSKGQHLYK-------EKPATQPVKRKLEDLSSEWKAVN-------RLLQ 1074
K P+++++ + G L A VK L+ E A N + L
Sbjct: 2376 SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT 2435
Query: 1075 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 1134
++ D++ G +G + + TK + + K + SS M++
Sbjct: 2436 SIKKDMTDISHGYEDLGLLLKDKIAELN----TKLSKLQKAQEESSAMMQ---------- 2481
Query: 1135 WTELTDWLSLLDQVIKS--QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192
WL +++ Q D E + + + K+ +L+Q +++EL
Sbjct: 2482 ------WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2535
Query: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252
L + + + I ++W E+ + +R+Q+L E + TQ+ + + +Q L
Sbjct: 2536 LLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL 2595
Query: 1253 GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD 1310
+ + GP ++D T+ +Q+ L+++ T L A + + +
Sbjct: 2596 VEKELMVSVL--GPLSIDPNMLN-TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE 2652
Query: 1311 DTRKVHMITENINA---SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
D ++ E + A W S+ ++S+R +++ Q+ L L++ +
Sbjct: 2653 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2712
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
++ L +T + + + + +++ ++ Q + +I+ + +L ++ E
Sbjct: 2713 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--- 2769
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLE---ASSDQWKRLHLSLQELLVWLQLKDDE 1483
L R+L+ + + ++ +K+ N HL+ ASS Q++++ Q WL K +E
Sbjct: 2770 ----LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEE 2822
Query: 1484 LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQE 1543
++ PI ++ H+ F + L + + T+ L + +G EK
Sbjct: 2823 QNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEK---- 2876
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL- 1602
L+ Q + T W+ N + + K+ E+LE+ + +E + L
Sbjct: 2877 --------------AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 2922
Query: 1603 ---DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
D E IK P ++ + K+K+L+ E+ V +N+ A L
Sbjct: 2923 PWIDKCQNNLEEIKFCLDPAEG------ENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2976
Query: 1660 TL 1661
++
Sbjct: 2977 SV 2978
Score = 94.7 bits (234), Expect = 9e-19
Identities = 322/1853 (17%), Positives = 708/1853 (38%), Gaps = 350/1853 (18%)
Query: 2 SARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 61
S + L+ + +K + + LL+Q++ E E ++ +Q+ L ++D+
Sbjct: 615 SLQTLKLMQIRKPLLKSSLLDQNLT---EEEINMKFVQDLLNWVDEM------------- 658
Query: 62 MPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA 121
++Q D T L ++ H + + R + +
Sbjct: 659 ------QVQLDRTEWGSDLPSVESHLENHKNVHRAIEE---------------------- 690
Query: 122 NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEM 177
FE L+E+K + E++M P T + + ++SQ LN N + L + + V
Sbjct: 691 -FESSLKEAK--ISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSR 747
Query: 178 VIKTGRQIVQKKQTENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
+ +K++ E + ER T + K ++ EL ++ ++++ ++ +++ ++
Sbjct: 748 ATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL 807
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEV 290
E + R +E + + ++ +W + ++ I++ + + +
Sbjct: 808 ENH-------------PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 854
Query: 291 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 350
EA + K+ ++ K S S+ I + +L+ E + E Q I
Sbjct: 855 KEATDYLRNLKDA-IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANL 907
Query: 351 IIQADTLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
+ +A T++ + KP+ + LK +KA + + ++ +D L N K
Sbjct: 908 MGKAKTII----QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 963
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----L 463
++ P +E + +A +EQ ++ L ++ V+ +
Sbjct: 964 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 1023
Query: 464 KEEDFNKDMNEDNEGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQ 508
E D + N ++K +L Q NLQ R D E +E +++++
Sbjct: 1024 NEID---RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1080
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE- 565
+ K + L+S R++ E + Y + + L C D + +++ + P RD+
Sbjct: 1081 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDL 1139
Query: 566 -------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 618
+ +++ +EL++ K++L + + E AA + PT
Sbjct: 1140 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT-------------- 1185
Query: 619 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLN 675
+R E +V+ ++M ++ + STY+ ++ V+ L E L+
Sbjct: 1186 --------------LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1229
Query: 676 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQ 731
+ + E + + +++N+ +L+Q +D + H+ + ++ + +
Sbjct: 1230 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1289
Query: 732 EALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI-------------------- 771
LDF W K + D+ VE+W+ H I
Sbjct: 1290 YKERDLDFDWHKE---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1340
Query: 772 -FNQWLTEAEQFLRKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNA 820
+ W+ + E RK Q PEN + + K + E+ Q + + Q +A
Sbjct: 1341 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1400
Query: 821 TGEEIIQQSSKTDASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRD 875
T ++ Q+ A + ++ + R + + ++ D + R +++++ +
Sbjct: 1401 TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1460
Query: 876 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 935
+ + LEE E E++ KE +E+ K L + + LK + G P
Sbjct: 1461 AGDSLKRLEEE--------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1512
Query: 936 SAPISPEEQDKLENKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ-------- 981
IS EE + +L + LQ I++ + E++ E+E Q+K L +
Sbjct: 1513 KQKISSEEISTKKEQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1571
Query: 982 ---------------LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 1021
+E+K+ ++ +E+L + L+ N+L + + G V
Sbjct: 1572 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631
Query: 1022 QETEIAVQAKQPDVEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRA 1078
+ + Q+KQ ++++ + E K +K E LS E KA + + L E +
Sbjct: 1632 ELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689
Query: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
K L + VT + K A+ +LE S +E L
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NL 1736
Query: 1139 TDWLSLLD-----------QVIKSQ---------RVMVGDLEDINEMIIKQKA------T 1172
DWLS +D QVI+ + +G+ +++N +++ T
Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
Query: 1173 MQDLEQR----RPQLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQE 1222
++L Q+ + Q E++I+ Q + T + ++ + + + E++Q E++
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
Query: 1223 HLQN------RRQQLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKK 1275
H + ++ +L L++ + +A E E L Q+ +LE+ + G ++ + K
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
Query: 1276 ITETKQLAKDLRQWQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENIN 1323
+ K ++D+ + + + ++ + L+ + S D R+V ++
Sbjct: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
Query: 1324 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 1383
+RS++ + + L++ Q + LA L E TA+ E + D
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVD 2032
Query: 1384 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMN 1439
K ++ +++ + LQG+I + L + ++ +L + L +D +Q+ LD++
Sbjct: 2033 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIV 2089
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ- 1498
++ +L K L+ + + + L E+L W+ + L Q + + A+Q
Sbjct: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2149
Query: 1499 --------------KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+Q+ ++ ++ K E ST +++ + + E ++
Sbjct: 2150 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2209
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
L E + L +E++ T E + + E Q +QE+T E
Sbjct: 2210 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2269
Query: 1605 KLRQAEVIKGSWQPVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1649
+ EV+ + + L+++ + +K K + I KE V+
Sbjct: 2270 HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2322
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 247 bits (630), Expect = 1e-64
Identities = 345/1755 (19%), Positives = 729/1755 (41%), Gaps = 165/1755 (9%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEAQKIQSDLTS 75
KLL+++ ++ E ++ ++E + + + + A++ + +Q P E + I L
Sbjct: 3356 KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNM 3415
Query: 76 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 123
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3416 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3475
Query: 124 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 169
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3476 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3535
Query: 170 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 229
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3536 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3595
Query: 230 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 289
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3655
Query: 290 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 348
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3656 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3715
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3716 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773
Query: 409 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 456
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833
Query: 457 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 506
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 566
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3953
Query: 567 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 626
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3954 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009
Query: 627 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 4010 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 4064
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 4123
Query: 747 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 804
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180
Query: 805 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 857
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4240
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4241 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4300
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 974
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4301 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4356
Query: 975 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4357 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4412
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4413 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4456
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4457 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4494
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4495 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4553
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4554 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4613
Query: 1272 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 1331
++++ ++ + ++L + N+ W S+
Sbjct: 4614 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4673
Query: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 1391
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4674 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4727
Query: 1392 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 1451
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4728 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4786
Query: 1452 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 1511
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4787 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4846
Query: 1512 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 1571
K V +T T R L + + L E+ +W
Sbjct: 4847 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4887
Query: 1572 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 1630
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4888 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4945
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 1683
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005
Query: 1684 QVAVEDRVRQLHEAH 1698
Q +E +RQ E H
Sbjct: 5006 QTRLEAALRQAEEFH 5020
Score = 217 bits (553), Expect = 9e-56
Identities = 319/1711 (18%), Positives = 674/1711 (39%), Gaps = 190/1711 (11%)
Query: 12 KKAVRRQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 65
KK +R L++++ Q A E+ S + E L K +A KV AQ+ QE
Sbjct: 3470 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QE 3526
Query: 66 AQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 125
+ +Q L + ++E +K+ + ++ + K+L + ++ A
Sbjct: 3527 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRN 3585
Query: 126 RLQESKMI--------LDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEV--- 171
R E + L+ + L +E + V E + +Q L + +K+L +
Sbjct: 3586 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3645
Query: 172 -KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
+ + G+ + E+ + ++ ++ Y E+ K R + L++ L ++
Sbjct: 3646 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3705
Query: 231 KMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 290
++ L WL +L+K S + L + + + Q++I +K ++
Sbjct: 3706 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3765
Query: 291 G-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 349
G E LK G + +++DKL + + + +T + + L + + + +
Sbjct: 3766 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3825
Query: 350 WI--IQADTLLDESEKKKPQQKEDVL---KRLKAELNDIRPKVDSTRDQAANLMANRGDH 404
W+ ++ + L E++ K ++ K LK E + + +DS + ++ L+
Sbjct: 3826 WLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3885
Query: 405 CRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQFNSDI-----------QKLLE 451
R+ +E ++E N R+ +S I K + + +QF+ +KL+
Sbjct: 3886 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3945
Query: 452 PLEAEIQQGVNLKEEDFNKDMNED---NEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 508
+ ++Q + K + ++ + +L++ G + ++E K + +K K
Sbjct: 3946 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLD 4004
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP------ 562
+ ++ + + S+R + Q+ ++L L + + ++ LP P
Sbjct: 4005 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 4064
Query: 563 -----RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 617
+ R+++E+ E + +++N Q LS G +++ + + +I+
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE 4123
Query: 618 KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 677
++ A + + T D LE L + +S + ++++ ++
Sbjct: 4124 ---DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180
Query: 678 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 737
+ D E L E+LK + + SG D S K +Q+ L Q+
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQM 4227
Query: 738 DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-------- 789
F WE ++ + ++R+ + +E +F D + + + F+R + P
Sbjct: 4228 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4287
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 849
+ E A+ ++E DG+ + +V L G E+I + D I+++ + LN W
Sbjct: 4288 QQQEAAET---IREEIDGLQEELDIVINL---GSELIAACGEPDKPIVKKSIDELNSAWD 4341
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQ 908
+ K DR +LEE ++Q L W++ A +AS+ + +K+++E+
Sbjct: 4342 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4401
Query: 909 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALP 966
+K E +Q +++LN +L EE DK +++ L + L W + +
Sbjct: 4402 LKQFKSEAYQQQIEMERLNHQAELLLKKVT---EESDKHTVQDPLMELKLIWDSLEERII 4458
Query: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
+Q ++E + LGQ + L++L L WL+ L Q G E E+
Sbjct: 4459 NRQHKLEGALLALGQFQHALDEL-------LAWLTHTEGLLS--EQKPVGGDPKAIEIEL 4509
Query: 1027 A--------VQAKQPDVEEILSKGQHLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQEL 1076
A V A Q VE + G L + + ++ KLE L+ W+ V
Sbjct: 4510 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV------- 4562
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
++T K ++ +L F+
Sbjct: 4563 ------------------------------LEKTEQRKQQLDGALR----QAKGFHGEIE 4588
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
+L WL+ ++ + + + + G E E + E + + L+ Q + +
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4648
Query: 1197 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 1256
+ A T I I ++ +W+ V+ L R+ +L E L + ++ + ++ L QA
Sbjct: 4649 CP-KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4707
Query: 1257 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
L +D + +I E K A ++ + + + L D +
Sbjct: 4708 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4767
Query: 1317 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 1376
+ ++ + W + +R+ ER +L++ + +QF K + WL E+E + +
Sbjct: 4768 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD------S 4821
Query: 1377 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 1436
+ + D +K + Q ++ Q + A VY + + + +DD + L L
Sbjct: 4822 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4881
Query: 1437 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 1496
+ KW + KS+ ++ LE + + +LQ L+ WL + +L+ P+ GD
Sbjct: 4882 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL 4941
Query: 1497 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 1556
V D H+AF++EL + ++ L + REL E +++
Sbjct: 4942 VMNLIDNHKAFQKELGKRT-------------------SSVQALKRSARELI--EGSRDD 4980
Query: 1557 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 1616
+ ++ Q +E++T WE + S Q +++ L + +E L L +AE
Sbjct: 4981 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 5040
Query: 1617 QPVGD------LLIDSLQDHLEKVKALRGEI 1641
+ D LID ++ ++K++ R E+
Sbjct: 5041 GVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 5071
Score = 213 bits (541), Expect = 2e-54
Identities = 318/1675 (18%), Positives = 668/1675 (39%), Gaps = 181/1675 (10%)
Query: 12 KKAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK-- 68
+K+ R +LL+Q++ +A+ E + L+ DK + D Q+++
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3747
Query: 69 IQSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN----- 122
+Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3748 LQEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805
Query: 123 FEQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 172
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K
Sbjct: 3806 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNK 3865
Query: 173 SEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM 232
+ ++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3866 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3925
Query: 233 RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 292
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3926 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3985
Query: 293 ALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3986 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 4045
Query: 352 IQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 4046 TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 4105
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ-- 459
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 4106 S----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161
Query: 460 ---GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQ 507
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4162 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 508 QLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR- 563
L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4281
Query: 564 DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFA 620
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4282 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4341
Query: 621 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 680
+ +I + EE M + Y + V + L +
Sbjct: 4342 SLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPI 4388
Query: 681 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDF 739
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4389 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4449 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEI 4507
Query: 800 YLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS 856
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567
Query: 857 DRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVE 914
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCA 4626
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIE 973
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4627 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLE 4683
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---A 1027
+ + L+D + WL+ L + ++P+ F + E ++
Sbjct: 4684 EALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4736
Query: 1028 VQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLA 1084
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4737 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------- 4789
Query: 1085 PGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL 1144
SL F+ AW++L +WL
Sbjct: 4790 -----------------------------------SLDDARKRAKQFHEAWSKLMEWLEE 4814
Query: 1145 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 1204
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4815 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL 4874
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 1264
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4875 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4934
Query: 1265 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4935 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELST 4993
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLL 1381
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4994 RWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL 5053
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
D KE MK+ ++ + E+ T + + ++ D ++ + + +
Sbjct: 5054 IDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRAR 5103
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQK 1499
+ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163
Query: 1500 QNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQ 1542
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5164 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYP 5223
Query: 1543 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5224 SGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5270
Score = 206 bits (525), Expect = 2e-52
Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 78
K L Q + E S E++T K+ + Q +E I L S
Sbjct: 3129 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3188
Query: 79 SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 124
S + + +++ Q + Q+D+A++ QD+ ++ + Q+ +
Sbjct: 3189 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3248
Query: 125 QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q++ E L+ E L ++ + E +Q Q
Sbjct: 3249 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3308
Query: 164 LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 222
K L + + + KT + ++ ++T + + + AL N+L + R++Q+
Sbjct: 3309 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3368
Query: 223 EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 281
E +K + ++ + L + + V ++ ++ K QK EIE +
Sbjct: 3369 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3428
Query: 282 VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 339
+ + +G+ L K + +E L +N+ W + + + L E H
Sbjct: 3429 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3488
Query: 340 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 399
F ++ + W++ + L+ + +K P + V+K E ++ +D R ++
Sbjct: 3489 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3545
Query: 400 NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 451
G+ EP Q+S L+ R+ A+ ++ +T ++LE + Q+ E
Sbjct: 3546 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3600
Query: 452 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 509
LE + +++ N + ++E + + L+ I + K + + I Q L
Sbjct: 3601 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3660
Query: 510 LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 568
KD+ + L+ S WY + + ++ + L E DE ++
Sbjct: 3661 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3714
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
E+ K +L+ EGL + + + V I L K + ++ LN
Sbjct: 3715 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3767
Query: 629 QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 681
++ T +E +++ + ++ Y T L T++ + L++ + L++ +LC
Sbjct: 3768 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3827
Query: 682 -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+E + K EE+ K +K + + +D ++ +A L+ R
Sbjct: 3828 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3887
Query: 728 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 785
L++ +++ + ++ V+ + D ++ + ++F W+TE E+ L
Sbjct: 3888 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3947
Query: 786 -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
++ ++ A+ + K I + + ++ L +G +I+ S+ + +++KL +
Sbjct: 3948 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 4006
Query: 845 NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 903
+ +C+ S+R +LE ++++++F E WL E +I S +P + + L+
Sbjct: 4007 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 4066
Query: 904 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 963
++ E+ + L E + + + ++N+TG +L +SP E ++ K + + ++
Sbjct: 4067 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 4123
Query: 964 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1022
+ ++ ++ I Q K++ + E L ++ L P E+ + +E + +
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4181
Query: 1023 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1076
+ ++ QP E + +G+ + T + V+ KL+ + W+ ++ L++E
Sbjct: 4182 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4241
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
AK +L+V LA+ + W
Sbjct: 4242 EAK------------------------------------------LLDVMELAE--KFW- 4256
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1193
D +SL+ IK + + DLED I+ ++K Q+ + + + L+E + NL
Sbjct: 4257 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4313
Query: 1194 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1250
++ + + I+ I+ + + WD + + ++R +L E ++ + Q+ + +
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4373
Query: 1251 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1310
+ A KL S ++ ++++I E KQ + Q Q ++ N A LL+ + +
Sbjct: 4374 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4433
Query: 1311 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1369
D V + W S+ +R+ R+ LE L QF L++ LAWLT E
Sbjct: 4434 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4491
Query: 1370 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1429
+ ++ + D K ++ + + LQ ++ AH +++ ++ S G ++A
Sbjct: 4492 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4546
Query: 1430 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1489
LQ +L+ +N +W + +K+ + L+ + Q K H +++L WL + L P
Sbjct: 4547 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4606
Query: 1490 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1549
+GG ++Q +VH + KE S ++ + L P + Q+ L
Sbjct: 4607 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4664
Query: 1550 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1609
+WE + + + K++E L E + + L QA
Sbjct: 4665 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4706
Query: 1610 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1668
E + + +P L++D++ +++ K E+ +E + ++ L +
Sbjct: 4707 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4764
Query: 1669 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1699
+ + L + +RW+ + + +R R L +A +
Sbjct: 4765 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4796
Score = 198 bits (503), Expect = 6e-50
Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 77
++Q+I + + + L + + L+ +D +L++ +A M Q+ AQK++ ++ +
Sbjct: 2823 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2882
Query: 78 ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 122
+ EE K ++ + S DV QK V
Sbjct: 2883 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2942
Query: 123 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 182
F+Q ++ + LD K S + +V++S + + K+L+ E I G
Sbjct: 2943 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 3002
Query: 183 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 242
++ K Q L ++ +K +++ +V ER+ +L++ L+ + K ++++ L W
Sbjct: 3003 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 3062
Query: 243 LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 301
+ L + + ++ P+ ++ +A K+ QKE+++ ++ + +L +V
Sbjct: 3063 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 3120
Query: 302 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 361
+ +V D+ L VT + L + + F + + + A LD
Sbjct: 3121 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3180
Query: 362 EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 416
+ Q + +L+ + L ++ +VD + A +L+ D V Q+ +
Sbjct: 3181 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3240
Query: 417 NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
+ +S ++ K L+ + F + I+++ + ++ + + +
Sbjct: 3241 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3300
Query: 475 DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 520
+ T+K L++ DN + T+E + + IK+ L L + N L D
Sbjct: 3301 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3359
Query: 521 RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 568
R+Q R++ +E + ++Y ++ LL+ ++ E+ + ++ + + K+
Sbjct: 3360 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3419
Query: 569 -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 622
KE LQ K++++N + +GL + A +E ++ RW+ + K AQ
Sbjct: 3420 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3476
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+L A +H R + + + +++ E+L+ +
Sbjct: 3477 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3515
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
+F+ + Q + K ++ L +++I + +A P ++VK+ + LS LD +WE
Sbjct: 3516 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3575
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 801
+ + R + + ++FH ++ N+WLT E+ L + P + +K + +
Sbjct: 3576 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3634
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+D I + + G+ + SS+ D ++Q KL + + E+ ++ R
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
+ L++ F D E + WL E D ++ + ++ + L ++ ++++L E++ L
Sbjct: 3695 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3754
Query: 919 R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 963
R Q +L L TG VL+ + ++ KL + +T Q ++++R
Sbjct: 3755 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3814
Query: 964 ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 996
L E+ E Q+ K+L + K + L + LN +
Sbjct: 3815 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3874
Query: 997 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1051
LL L P R LE + E V +T + K +++ + + Q + A
Sbjct: 3875 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3931
Query: 1052 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1090
T+ L D+ E + LQ + + D+ L T
Sbjct: 3932 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3991
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1147
Q++ V+ I ++ L LE A + N+ W EL WL+
Sbjct: 3992 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 4050
Query: 1148 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
+I + E + + + + + + + +P ++++ L + + I
Sbjct: 4051 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 4108
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1266
++ + +++E ++ R L+E + STQ+ ++ +Q+L +E ++ P
Sbjct: 4109 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4165
Query: 1267 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1323
V+ I+++I+E K ++ D+ + Q + +++ R D + + ++
Sbjct: 4166 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4225
Query: 1324 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
W +IH V EREA L + L ++F D + + + + L+D +
Sbjct: 4226 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4285
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
++ + E ++ +++ G ++ D+ NL L + G D ++++ +D +N
Sbjct: 4286 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4338
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
W L K + LE + + LQ + W+ + +L+ +PIG D V++Q
Sbjct: 4339 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4398
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
+ + FK E +Q +E +E+L + L + ++ +
Sbjct: 4399 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4439
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
+ E+ W+ L + Q K++ L L + Q A DEL L E + +PVG
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1679
+++ L K L+ ++ + V VN L NL + LE LN R
Sbjct: 4500 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4558
Query: 1680 WKLLQVAVEDRVRQLHEAHR 1699
W+ + E R +QL A R
Sbjct: 4559 WQNVLEKTEQRKQQLDGALR 4578
Score = 191 bits (486), Expect = 6e-48
Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)
Query: 33 KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 88
++L +E++ K+L A +A +A +M ++ DL + LE + K N+
Sbjct: 3297 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3356
Query: 89 GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 148
+ AQ Q++ K+L++ F +L+E ++L + + H +
Sbjct: 3357 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3403
Query: 149 VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 206
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3404 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3463
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
+ L KV +R QL++ L + + + L W+ T+ + + + ++
Sbjct: 3464 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3523
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 325
+ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++AE
Sbjct: 3524 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3583
Query: 326 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 383
L + F + ++ + +W+ + L E Q E+ + + KA +DI
Sbjct: 3584 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3643
Query: 384 RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 438
Q+ ++++R D + +V+ ++ F+ + + I+ + S E
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3695
Query: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 496
L Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3749
Query: 497 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 556
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K L
Sbjct: 3750 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 557 ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 614
+ R++ EL K E+ + + + L + A+ A + +L K +
Sbjct: 3807 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3863
Query: 615 IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3922
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 728
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3982
Query: 729 ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 774
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3983 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 4042
Query: 775 -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 4043 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102
Query: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 890
SI QEK + + + ++ + + R L+E + ++F +++ + LE + +
Sbjct: 4103 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161
Query: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 948
P + +++KE++ + K + ++ Q + + L + G ++ + + ++ ++
Sbjct: 4162 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 949 NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1006
+KL Q W + + E+ EA++ D+ +L +K +H L++ + ++
Sbjct: 4222 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4272
Query: 1007 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1058
+ P + Q+ E A + Q +++ +++ G L +P VK+
Sbjct: 4273 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4332
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
+++L+S W ++N+ ++ I KLE
Sbjct: 4333 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4357
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
+ A + + DW+ + + S + DLE + + I + K + Q
Sbjct: 4358 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411
Query: 1179 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1238
++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4412 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4471
Query: 1239 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1298
Q+ A +E L L K AI+ ++ + L D+ Q+ V+ N
Sbjct: 4472 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4531
Query: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4532 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4591
Query: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
WLT+ E + + L + KE + ++ EA + Y +L + Q++
Sbjct: 4592 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4645
Query: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
L S + + + ++N+ KW + K ++ LE + + H SLQ+ + WL
Sbjct: 4646 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4704
Query: 1479 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1535
+ L+ + V Q D H+ F E+ + I+ +T ++ F +Q +
Sbjct: 4705 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4764
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1585
++ L + + R + V + L RK+A++ + W KL +W +
Sbjct: 4765 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4815
Query: 1586 DETLERLQELQEATDELDLKLRQ 1608
+++L+ E+ D++ +L Q
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQ 4838
Score = 161 bits (407), Expect = 8e-39
Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)
Query: 30 ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 88
ETEK L + + D+ A K ++ + I + S H+I ++ Q
Sbjct: 3938 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3997
Query: 89 G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 146
K+ +VL D + + ++ Q N F + +E L E + + L
Sbjct: 3998 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 4057
Query: 147 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 206
++E E ++ Q L + ++E K ++ + KTG Q+++ E + E+ A
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 4116
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
Y+++ V +R L++ + S + +++ + E L L + ++ + +
Sbjct: 4117 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4176
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 321
++ K ++EK + +++ + GE + G + V+DKL + W + +
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4236
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 374
EE LL+ + E F DH++ + DT + + P +Q+++ +
Sbjct: 4237 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4294
Query: 375 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 432
++ E++ ++ ++D + + L+A G+ + +V+ I ELN + +++ K K
Sbjct: 4295 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4354
Query: 433 SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 472
++ Q+ +Q + LE ++ +I++ K E + + +
Sbjct: 4355 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4414
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ L + + L +++T+E + ++ L+ ++L++ R+ K
Sbjct: 4415 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4468
Query: 533 HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 584
Q++ D+LL L E L+ + K EI+ ++ + + A
Sbjct: 4469 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4528
Query: 585 VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 635
V + L E A Q +L ++RW+ + K Q ++ L A+ H E
Sbjct: 4529 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4588
Query: 636 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 695
+ +T+ ++ P L E EQL ++CA FE +EE+ K
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4636
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 755
++ QQ R K+A + + ++ L +WE V +R+ +
Sbjct: 4637 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4682
Query: 756 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 809
+ ++ FH ++ F WLT+AEQ L P ++ ++K + E+
Sbjct: 4683 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4739
Query: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869
R+ ++ L+ TG + S K D +++ L S+ RW++V ++L +R + L++ +
Sbjct: 4740 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4798
Query: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 928
+F ++ + WLEE++ LE + ++K +L Q K + L + + N
Sbjct: 4799 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4858
Query: 929 TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 988
TG + ++ ++ KL++ L + +W + E+Q ++E + GQ L+
Sbjct: 4859 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4917
Query: 989 LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1048
L + WL + QL +QP G D+ I D + K L K
Sbjct: 4918 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4959
Query: 1049 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+ Q +KR +L S W V +QEL + +TV ++
Sbjct: 4960 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 5002
Query: 1103 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1161
T+ E A+ + E +F+ L +WL+ +Q ++ V+ D +
Sbjct: 5003 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049
Query: 1162 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1215
+ +I + K M+ LE++R +L + T + + T+ + TII R E +
Sbjct: 5050 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 5109
Query: 1216 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1256
+ Q+ L + +Q+L E L QW E EE + ++ + +
Sbjct: 5110 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5169
Query: 1257 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1310
+E VD K+T+T K+ A D Q+++ V A Y +
Sbjct: 5170 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5225
Query: 1311 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1359
++ +N + W+ + ER L + L++ F D+ +K++
Sbjct: 5226 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5285
Query: 1360 WLTEAET 1366
W+ ++
Sbjct: 5286 WMNHKKS 5292
Score = 159 bits (402), Expect = 3e-38
Identities = 324/1735 (18%), Positives = 696/1735 (40%), Gaps = 227/1735 (13%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 71
K +QK+ + I + +E + E+L I LA + DK+ + + +++++
Sbjct: 1646 KPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKH-GDKMTDEERNELEKQVKT 1698
Query: 72 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL--- 127
S+ + E K Q + + V + + ++ Q+ K + + E RL
Sbjct: 1699 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1758
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
QE+ MI D + L ++K QE +Q + ++L+EV E +K +
Sbjct: 1759 QEAFMIGDGT-VELKKYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE--- 1808
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
K E+ +++++ K+ +L K + K++L+K + + K TE +AA
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVK 1862
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVE 306
++ +E + + W K+ E+ H + I + G + GK E
Sbjct: 1863 QLEESKTKIENL-------LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE 1915
Query: 307 DKLS--LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-E 360
D+++ LL ++ +E NL +YQK ++ + II A LL+ +
Sbjct: 1916 DEVNGNLLETDVDGQVGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQ 1973
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
+ P++KE + K +K +++ ++ ++ M ++ ++ + + +
Sbjct: 1974 GQYLSPEEKEKLQKNMK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADY 2024
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
H ++ + L+ LE DI L+ L+ +++ F++D+ ++G +
Sbjct: 2025 TEFEHWLQQSEQE--LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDL 2072
Query: 481 KELLQRGDNLQQRITDERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKAL 529
+ + G+ + + KR+ K+ Q+ L + + L S+
Sbjct: 2073 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 2132
Query: 530 EISHQWYQYKRQADDLLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKK 579
++ ++ Y+ + LL L E + L EP R + K + ++ ++
Sbjct: 2133 DLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQ 2192
Query: 580 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 639
+ +++ AE L + A ++ P + + K +I ++ + ++ E+ +
Sbjct: 2193 VAVEKLKKTAEVLLD--ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQI 2246
Query: 640 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIK 698
+T + ++ L + +V +L E Q+ LN+ L +D+ + L+
Sbjct: 2247 TLTRSLSVQDGL--DEMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDI 2299
Query: 699 DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRS 758
Q S I+ ++ K +++ P LQ + L ++ + + +K+ + +
Sbjct: 2300 AGRQSS---INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2356
Query: 759 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 818
K F + +L Q L + +P + + Y++E + + + L
Sbjct: 2357 KTKVELFENLSEKLQTFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVL 2415
Query: 819 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE 878
++ +EI +D +++ EK +L+ +++E+ + ++K+ + + L FQ +
Sbjct: 2416 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475
Query: 879 FVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVS 936
W++E I + L + LE K L E+ L+ ++++N +G + L+S
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535
Query: 937 APISPEEQDKL----------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK- 984
A +P + E T W K ++ + +I +DLG L K
Sbjct: 2536 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2595
Query: 985 ----------KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP- 1033
KL+ +E+ + ++ WL + + Q P D + + V+ +
Sbjct: 2596 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSF 2653
Query: 1034 ---------DVEEILSKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQP 1081
V+E+ K L +E P T K+ L ++ S+W+ +N+L + + K
Sbjct: 2654 EAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2713
Query: 1082 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1141
+ + LT Q + Q +V KE +S L
Sbjct: 2714 ESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGP------------------------ 2745
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
LS+ ++ +QR V + +Q+ R+PQ E+L A Q + ++
Sbjct: 2746 LSIDPNMLNTQRQQV-------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDP 2792
Query: 1202 A-RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+ R I+ +++ + +WD + L +R +++ + STQ+ L KL
Sbjct: 2793 SLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS 2852
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKV 1315
S DA+ +++ +++ ++++Q + + VA DL+ + +Y A+ +R++
Sbjct: 2853 SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQL 2912
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
I ++ + V ++A +H+ QQ D F AWL + N +
Sbjct: 2913 EGILKSFKDVEQKAENHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPIS 2968
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
K +LE L+K +D + A + +Y + +L +GS+ A LQ +L
Sbjct: 2969 AKLDVLE------SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQL 3021
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIG 1491
+ + W K+ + L+ S ++ + ++ L W+ + L P
Sbjct: 3022 NTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE 3081
Query: 1492 GD-----FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
G+ ++QK+ D H L ++S E + +T++ ++K+ +
Sbjct: 3082 GENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 3141
Query: 1547 LPPEERA-QNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEA 1598
L ++ +N+T+ K+ +EV+ E K L A Q I ++L + L LQ
Sbjct: 3142 LHSKKFCLENMTQKF-KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199
Query: 1599 TDELDLKLRQAEVIKGSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1648
L Q ++ K Q DL++++ D L +V+ + E + L + V
Sbjct: 3200 QKSLQALKHQVDLAKRLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3251
Score = 149 bits (376), Expect = 3e-35
Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)
Query: 47 KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 104
K L+ IA D + + +E + +Q ++S ++++E++KK + +A +L + Q
Sbjct: 2161 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2220
Query: 105 KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 154
K L D+ ++ K N + L S + LDE+ + +E+ EQ V
Sbjct: 2221 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280
Query: 155 -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 209
Q ++ + L + ++ +S + + + ++ ++ L ++ L ++
Sbjct: 2281 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2340
Query: 210 ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
E AK+ E K ++E LS K++ + T+ A T++++ + E +
Sbjct: 2341 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2397
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 322
+ + +K +E LK I+ G L + LV +K + L+ + +
Sbjct: 2398 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2451
Query: 323 AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 369
+E + Q+ ++ F V + W I+Q A+ L E K Q+
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2511
Query: 370 EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 402
+ LK + + L ++ V + T AN+G
Sbjct: 2512 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2571
Query: 403 ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 446
+ L++ +I+ELN + + + + A + L+++ + +
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2631
Query: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Q+ P + E + + + F ++ + N V+EL + L + D + K
Sbjct: 2632 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2690
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 565
+ +K L L R++K E S+ Q++ L + L + E ++ L P D
Sbjct: 2691 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2750
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+ +++Q +E + Q E L+ G + P + + +
Sbjct: 2751 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2800
Query: 626 NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 682
A + T + +++ D ++ + V ST Y + + +S L +++ L++ +
Sbjct: 2801 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2859
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 740
+ + +Q E+ + +K +QQ +I + + + +AL VK + ++L Q
Sbjct: 2860 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2911
Query: 741 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 800
E + K +KD + + + V+ + F Q + + +L + +N H
Sbjct: 2912 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2970
Query: 801 LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 850
L L+ I + +TL A GE ++ ++ ++ + LQ +L ++ W
Sbjct: 2971 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 3030
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 907
KQ+ +R+ +L+E +++ + W+++ +N+ I L+P + + KL
Sbjct: 3031 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 3089
Query: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 967
K L +E+ G+++ LN T +L I E ENK
Sbjct: 3090 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 3129
Query: 968 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1027
L +K++ + EQL+ L + + + + + ++E + ++
Sbjct: 3130 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3171
Query: 1028 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+Q D+ + L + K Q ++ L+ L + RL Q+L + D
Sbjct: 3172 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3226
Query: 1088 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ T V L + + + + +S+ E S L ++ + F E+ +
Sbjct: 3227 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3282
Query: 1146 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1205
D + S + D E + KQK T++ ++ LE L+ + N NKT T
Sbjct: 3283 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3334
Query: 1206 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1257
T +E + Q +++ + Q R +Q+ +K ++ +E +L +A
Sbjct: 3335 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3394
Query: 1258 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1315
ES + I +++ K K+ + Q N L L++ + + T+ +
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
+++NA W++++K+V++R A L+E +F LE L+W+ + E A
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3509
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
+K E K VK +++ + LQ ++ + +KI + E +D +L ++L
Sbjct: 3510 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3567
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1495
++ +W L K+ LE S ++ H +L+ L WL + L PIG
Sbjct: 3568 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3627
Query: 1496 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1550
+++Q H+A + ++ + +S +++++ + + + ++ + + + +
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3687
Query: 1551 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1605
E++ + + LL++ E + +W ++ + L +L +T+ L +L+
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3746
Query: 1606 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1651
+ Q +++ Q V L++ L QD LE +KA +I L +V+
Sbjct: 3747 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805
Query: 1652 NDLARQL 1658
+ A QL
Sbjct: 3806 LEQALQL 3812
Score = 129 bits (324), Expect = 3e-29
Identities = 348/1814 (19%), Positives = 706/1814 (38%), Gaps = 343/1814 (18%)
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDV-SMKFRLFQK 119
++ +E ++++ DL + EE + + S+++V + + V SM K
Sbjct: 1289 KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK 1348
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE--- 176
L+ ++ VK++ ETK E+E V + N+ NL +L + +SEV+
Sbjct: 1349 LKTVNLVLKNTQAAEALVKLY----ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1404
Query: 177 MVIKTGRQIVQKKQ--------TENPKELD-----ERVTALKLHYNELGAKVTERKQQLE 223
V +QK + T ++LD E+ L + + ++ R + LE
Sbjct: 1405 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1464
Query: 224 KCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
K + R + L +W+ +E T+R E P N
Sbjct: 1465 GIGKSLKYYRDTYHPLDDWIQ--QVETTQRKIQENQPEN--------------------- 1501
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ L T L +++ LV + + + S AE++ + +Y+ T+
Sbjct: 1502 -------SKTLATQLNQQKMLVSE-IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1553
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
VD K ++ +++ Q D++ + E D+R + + + GD
Sbjct: 1554 VDSQQKSPVK---------RRRMQSSADLIIQ---EFMDLRTRYTALVTLMTQYIKFAGD 1601
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE-----IQ 458
++L E + S + + KEL+++ S+I K L+ E +
Sbjct: 1602 SLKRLEEEEKSLEEEKKEHVEKA----------KELQKWVSNISKTLKDAEKAGKPPFSK 1651
Query: 459 QGVNLKEEDFNKDMNEDNEGTVKELLQR-GDNLQQRITDERKREEIKIKQQLLQTKHN-- 515
Q ++ +E K+ + T++ L + GD ++TDE +R E++ + + LQ +N
Sbjct: 1652 QKISSEEISTKKEQLSEALQTIQLFLAKHGD----KMTDE-ERNELEKQVKTLQESYNLL 1706
Query: 516 ---ALKDLRSQRRKKALEI-----SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK 567
+LK L+ + +++ + + +YK + + L E +L E
Sbjct: 1707 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAF---M 1763
Query: 568 IKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI--ESKFAQFRRL 625
I + EL+K + + +++ +G S A V+ T+ L + ++ E K ++L
Sbjct: 1764 IGDGTVELKKYQSKQEELQKDMQG-SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1822
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH-------VSQALLEVEQLLNAPD 678
N A+I E + + E E+ V +T + E T + ++ ++E LL+
Sbjct: 1823 NEAKIKC---EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1879
Query: 679 LCAKDFED------------------------LFKQEESLKNI------------KDSLQ 702
KD E + +++E N+ +++L
Sbjct: 1880 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1939
Query: 703 QSSGRIDIIHSKKTA-------ALQSA-----------TPVERVKLQEALSQLDFQWEKV 744
Q ++ H K + A QSA +P E+ KLQ+ + +L +E
Sbjct: 1940 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1999
Query: 745 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE---NWEHAKYKWYL 801
+ + E+ +F D F WL ++EQ L + N K K
Sbjct: 2000 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 2059
Query: 802 KELQDGIGQRQTVVRTLNATGEEIIQQS---SKTDASILQEKLGSLNLRWQEVCKQLSDR 858
+D I + + R + +G +++ + SK D + + + Q +DR
Sbjct: 2060 SFSEDVISHKGDL-RYITISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDR 2116
Query: 859 KKRLEEQKNILSEFQRDLNE-----------FVLWLEEADNIAS------IPLEPGKEQQ 901
+ L + N+L +DL + + L+ + AS I ++P +
Sbjct: 2117 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP---KN 2173
Query: 902 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA-----PISPEEQDKLEN------- 949
L+ +LE+ K L ++ +Q +++L +T VL+ A P + Q L++
Sbjct: 2174 LQRQLEETKALQGQISSQQVAVEKLKKTA-EVLLDARGSLLPAKNDIQKTLDDIVGRYED 2232
Query: 950 ----------KLKQTNLQWIKVSRALPEK---QGEIEAQIKDLGQLEKKLEDLEEQLNHL 996
KL+ T + + V L E G +E+ +K+ GQ+ L++ ++
Sbjct: 2233 LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN 2292
Query: 997 LLWLSPIRNQLEIYNQPNQEGPFDVQETE----IAVQAKQPDVEEILSKGQHLYKEKPAT 1052
++ I + N N++ ++ T+ ++QAK D+ S+ H +KE A
Sbjct: 2293 IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA- 2351
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
K+E+L ++ + L ++L+ LT + P + VT ++Q + +
Sbjct: 2352 -----KMEELKTKVELFENLSEKLQTFLETKTQALTEVDV-PGKDVTELSQYMQESTSEF 2405
Query: 1113 SK----LEMPSSLMLEVPA--LADFNRAWTELTDWLSL----LDQVIKSQRVMVGDLE-- 1160
+ LE+ SL+ E+ + L E T+ LS ++ IK ++ V +
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2465
Query: 1161 -DINEMIIKQ-KATMQDLEQRRPQLEELITA---AQNLKNKTSNQEARTIITDRIERIQN 1215
D ++++K K+ +++ ++ P ++ A ++L++ QE ++ T I+++ N
Sbjct: 2466 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2525
Query: 1216 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL---GQARAKLESWKEGPYTVDAI 1272
+ L + + + A + VL G A E W T +I
Sbjct: 2526 SGISLCN--------LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT--SI 2575
Query: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
+K +T+ +DL LL+D A+ ++ +
Sbjct: 2576 KKDMTDISHGYEDLGL--------------LLKDKIAE------------------LNTK 2603
Query: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
+S+ + A EE+ ++Q WL + TA Q D++ VK ++
Sbjct: 2604 LSKLQKAQEESSAMMQ-----------WLQKMNKTATKWQQTPAPT----DTEAVKTQVE 2648
Query: 1393 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
Q + + E++ + + L + ++L + +A ++ L ++ KW EL + +++
Sbjct: 2649 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2708
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 1512
+ LE SS+ + +L WL K+ +S P+ D + Q + +E
Sbjct: 2709 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2768
Query: 1513 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 1572
T++P EQ + + P E P ++ ++++Q V +W+
Sbjct: 2769 TRKPQY------------EQLTAAGQGILSRPGEDP------SLRGIVKEQLAAVTQKWD 2810
Query: 1573 KLNLHSADWQRKIDETLER-------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
L +D ID+ + + L+ L + +LD KL + + S P D
Sbjct: 2811 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV--STHP------D 2862
Query: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ--LSPYNLSTLEDLNTRWKLL 1683
++ LE + ++ EI K+ + L L+ L + L LE + +K +
Sbjct: 2863 AMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV 2922
Query: 1684 QVAVEDRVRQLHEA 1697
+ E+ V+ L A
Sbjct: 2923 EQKAENHVQHLQSA 2936
Score = 104 bits (260), Expect = 9e-22
Identities = 306/1742 (17%), Positives = 660/1742 (37%), Gaps = 286/1742 (16%)
Query: 97 LSQIDVAQKKLQDVSMKFRLFQKPANFEQ---RLQESKMILDEVKMHLPALETKSVEQEV 153
+ Q++ Q+K+Q+ +P N + +L + KM++ E++M
Sbjct: 1484 IQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMK------------- 1522
Query: 154 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPK----------------EL 197
QS+++ C + S + E+ T R +V +Q K +L
Sbjct: 1523 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1581
Query: 198 DERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEM-NVLTEWLAATDMELTKR 253
R TAL Y + +R ++ EK L+ +K E L +W++ L K
Sbjct: 1582 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL-KD 1640
Query: 254 SAVEGMP----SNLDSEVAWGKATQKEIEKQKVHL-----------KSITEVGEALKTVL 298
+ G P + SE K Q Q + L + E+ + +KT+
Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700
Query: 299 GKKETLVEDKLSLLNSNWIAVTSRAEEWL--NLLLEYQKHME--------TFDQNVDHIT 348
L + L L + + + EE + EY++ ++ T ++ + H
Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1760
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKR-LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
++I T+ E KK Q K++ L++ ++ + V +T + +
Sbjct: 1761 AFMIGDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1816
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIP----------------LKELEQFNSDIQKLLE 451
L+E +++E + ++ + + K + +K+LE+ + I+ LL+
Sbjct: 1817 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1876
Query: 452 PL---------------EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 496
L + Q G + +E D + E++E LL+ + Q T
Sbjct: 1877 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN-GNLLETDVDGQVGTTQ 1935
Query: 497 E---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLK---- 547
E ++ +++K + + + ++H A+ + +Q + LE Q+ + K + +K
Sbjct: 1936 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994
Query: 548 ----CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 603
L + EKK+ ++E +++ D + + + L ++ E L +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEE--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM 2052
Query: 604 TQIQLSKRWRE-IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 662
T+++ K + E + S R + + + + ++ S ++ H
Sbjct: 2053 TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH 2112
Query: 663 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESL---------------------------K 695
+ + N KD D ++ E K
Sbjct: 2113 ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK 2172
Query: 696 NIKDSLQQ--------SSGRIDIIHSKKTA-----ALQSATPVERVKLQEALSQLDFQWE 742
N++ L++ SS ++ + KKTA A S P + +Q+ L + ++E
Sbjct: 2173 NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN-DIQKTLDDIVGRYE 2231
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKWYL 801
++K +R + ++ + + W+ E L++ Q+P N A
Sbjct: 2232 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN-STALQDIIS 2290
Query: 802 KE--LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+ I RQ+ + +N ++ ++ + + AS LQ K+ L+ R+ E + +
Sbjct: 2291 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2350
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVE 914
++EE K + F+ + +LE + PGK+ Q ++E + +
Sbjct: 2351 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2410
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
L + +LK+++ G P DK K NL S+ E + I+
Sbjct: 2411 HLEVLHSLLKEISSHGLP-----------SDKALVLEKTNNL-----SKKFKEMEDTIKE 2454
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN------QEGPFDVQETEIAV 1028
+ + + +++L+ + + L W+ ++ I QP+ + D ++ +
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV-QPSFGAEDLGKSLEDTKKLQEKW 2513
Query: 1029 QAKQPDVEEILSKGQHLYK-------EKPATQPVKRKLEDLSSEWKAVN-------RLLQ 1074
K P+++++ + G L A VK L+ E A N + L
Sbjct: 2514 SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT 2573
Query: 1075 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 1134
++ D++ G +G + + TK + + K + SS M++
Sbjct: 2574 SIKKDMTDISHGYEDLGLLLKDKIAELN----TKLSKLQKAQEESSAMMQ---------- 2619
Query: 1135 WTELTDWLSLLDQVIKS--QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192
WL +++ Q D E + + + K+ +L+Q +++EL
Sbjct: 2620 ------WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2673
Query: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252
L + + + I ++W E+ + +R+Q+L E + TQ+ + + +Q L
Sbjct: 2674 LLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL 2733
Query: 1253 GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD 1310
+ + GP ++D T+ +Q+ L+++ T L A + + +
Sbjct: 2734 VEKELMVSVL--GPLSIDPNMLN-TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE 2790
Query: 1311 DTRKVHMITENINA---SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
D ++ E + A W S+ ++S+R +++ Q+ L L++ +
Sbjct: 2791 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2850
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
++ L +T + + + + +++ ++ Q + +I+ + +L ++ E
Sbjct: 2851 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--- 2907
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLE---ASSDQWKRLHLSLQELLVWLQLKDDE 1483
L R+L+ + + ++ +K+ N HL+ ASS Q++++ Q WL K +E
Sbjct: 2908 ----LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEE 2960
Query: 1484 LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQE 1543
++ PI ++ H+ F + L + + T+ L + +G EK
Sbjct: 2961 QNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEK---- 3014
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL- 1602
L+ Q + T W+ N + + K+ E+LE+ + +E + L
Sbjct: 3015 --------------AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 3060
Query: 1603 ---DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
D E IK P ++ + K+K+L+ E+ V +N+ A L
Sbjct: 3061 PWIDKCQNNLEEIKFCLDPAEG------ENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 3114
Query: 1660 TL 1661
++
Sbjct: 3115 SV 3116
Score = 94.7 bits (234), Expect = 9e-19
Identities = 322/1853 (17%), Positives = 708/1853 (38%), Gaps = 350/1853 (18%)
Query: 2 SARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 61
S + L+ + +K + + LL+Q++ E E ++ +Q+ L ++D+
Sbjct: 753 SLQTLKLMQIRKPLLKSSLLDQNLT---EEEINMKFVQDLLNWVDEM------------- 796
Query: 62 MPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA 121
++Q D T L ++ H + + R + +
Sbjct: 797 ------QVQLDRTEWGSDLPSVESHLENHKNVHRAIEE---------------------- 828
Query: 122 NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEM 177
FE L+E+K + E++M P T + + ++SQ LN N + L + + V
Sbjct: 829 -FESSLKEAK--ISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSR 885
Query: 178 VIKTGRQIVQKKQTENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
+ +K++ E + ER T + K ++ EL ++ ++++ ++ +++ ++
Sbjct: 886 ATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL 945
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEV 290
E + R +E + + ++ +W + ++ I++ + + +
Sbjct: 946 ENH-------------PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 992
Query: 291 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 350
EA + K+ ++ K S S+ I + +L+ E + E Q I
Sbjct: 993 KEATDYLRNLKDA-IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANL 1045
Query: 351 IIQADTLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
+ +A T++ + KP+ + LK +KA + + ++ +D L N K
Sbjct: 1046 MGKAKTII----QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 1101
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----L 463
++ P +E + +A +EQ ++ L ++ V+ +
Sbjct: 1102 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 1161
Query: 464 KEEDFNKDMNEDNEGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQ 508
E D + N ++K +L Q NLQ R D E +E +++++
Sbjct: 1162 NEID---RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1218
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE- 565
+ K + L+S R++ E + Y + + L C D + +++ + P RD+
Sbjct: 1219 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDL 1277
Query: 566 -------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 618
+ +++ +EL++ K++L + + E AA + PT
Sbjct: 1278 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT-------------- 1323
Query: 619 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLN 675
+R E +V+ ++M ++ + STY+ ++ V+ L E L+
Sbjct: 1324 --------------LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1367
Query: 676 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQ 731
+ + E + + +++N+ +L+Q +D + H+ + ++ + +
Sbjct: 1368 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1427
Query: 732 EALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI-------------------- 771
LDF W K + D+ VE+W+ H I
Sbjct: 1428 YKERDLDFDWHKE---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1478
Query: 772 -FNQWLTEAEQFLRKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNA 820
+ W+ + E RK Q PEN + + K + E+ Q + + Q +A
Sbjct: 1479 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1538
Query: 821 TGEEIIQQSSKTDASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRD 875
T ++ Q+ A + ++ + R + + ++ D + R +++++ +
Sbjct: 1539 TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1598
Query: 876 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 935
+ + LEE E E++ KE +E+ K L + + LK + G P
Sbjct: 1599 AGDSLKRLEEE--------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1650
Query: 936 SAPISPEEQDKLENKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ-------- 981
IS EE + +L + LQ I++ + E++ E+E Q+K L +
Sbjct: 1651 KQKISSEEISTKKEQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1709
Query: 982 ---------------LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 1021
+E+K+ ++ +E+L + L+ N+L + + G V
Sbjct: 1710 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1769
Query: 1022 QETEIAVQAKQPDVEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRA 1078
+ + Q+KQ ++++ + E K +K E LS E KA + + L E +
Sbjct: 1770 ELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1827
Query: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
K L + VT + K A+ +LE S +E L
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NL 1874
Query: 1139 TDWLSLLD-----------QVIKSQ---------RVMVGDLEDINEMIIKQKA------T 1172
DWLS +D QVI+ + +G+ +++N +++ T
Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934
Query: 1173 MQDLEQR----RPQLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQE 1222
++L Q+ + Q E++I+ Q + T + ++ + + + E++Q E++
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994
Query: 1223 HLQN------RRQQLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKK 1275
H + ++ +L L++ + +A E E L Q+ +LE+ + G ++ + K
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 2054
Query: 1276 ITETKQLAKDLRQWQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENIN 1323
+ K ++D+ + + + ++ + L+ + S D R+V ++
Sbjct: 2055 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 2114
Query: 1324 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 1383
+RS++ + + L++ Q + LA L E TA+ E + D
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVD 2170
Query: 1384 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMN 1439
K ++ +++ + LQG+I + L + ++ +L + L +D +Q+ LD++
Sbjct: 2171 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIV 2227
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ- 1498
++ +L K L+ + + + L E+L W+ + L Q + + A+Q
Sbjct: 2228 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2287
Query: 1499 --------------KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+Q+ ++ ++ K E ST +++ + + E ++
Sbjct: 2288 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2347
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
L E + L +E++ T E + + E Q +QE+T E
Sbjct: 2348 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2407
Query: 1605 KLRQAEVIKGSWQPVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1649
+ EV+ + + L+++ + +K K + I KE V+
Sbjct: 2408 HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2460
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 247 bits (630), Expect = 1e-64
Identities = 345/1755 (19%), Positives = 729/1755 (41%), Gaps = 165/1755 (9%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEAQKIQSDLTS 75
KLL+++ ++ E ++ ++E + + + + A++ + +Q P E + I L
Sbjct: 3178 KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNM 3237
Query: 76 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 123
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
Query: 124 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 169
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
Query: 170 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 229
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
Query: 230 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 289
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
Query: 290 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 348
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
Query: 409 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 456
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
Query: 457 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 506
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 566
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
Query: 567 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 626
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
Query: 627 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
Query: 747 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 804
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
Query: 805 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 857
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 974
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
Query: 975 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
Query: 1272 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 1331
++++ ++ + ++L + N+ W S+
Sbjct: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
Query: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 1391
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
Query: 1392 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 1451
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
Query: 1452 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 1511
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
Query: 1512 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 1571
K V +T T R L + + L E+ +W
Sbjct: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
Query: 1572 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 1630
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 1683
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
Query: 1684 QVAVEDRVRQLHEAH 1698
Q +E +RQ E H
Sbjct: 4828 QTRLEAALRQAEEFH 4842
Score = 217 bits (553), Expect = 9e-56
Identities = 319/1711 (18%), Positives = 674/1711 (39%), Gaps = 190/1711 (11%)
Query: 12 KKAVRRQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 65
KK +R L++++ Q A E+ S + E L K +A KV AQ+ QE
Sbjct: 3292 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QE 3348
Query: 66 AQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 125
+ +Q L + ++E +K+ + ++ + K+L + ++ A
Sbjct: 3349 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRN 3407
Query: 126 RLQESKMI--------LDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEV--- 171
R E + L+ + L +E + V E + +Q L + +K+L +
Sbjct: 3408 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3467
Query: 172 -KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
+ + G+ + E+ + ++ ++ Y E+ K R + L++ L ++
Sbjct: 3468 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3527
Query: 231 KMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 290
++ L WL +L+K S + L + + + Q++I +K ++
Sbjct: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587
Query: 291 G-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 349
G E LK G + +++DKL + + + +T + + L + + + +
Sbjct: 3588 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3647
Query: 350 WI--IQADTLLDESEKKKPQQKEDVL---KRLKAELNDIRPKVDSTRDQAANLMANRGDH 404
W+ ++ + L E++ K ++ K LK E + + +DS + ++ L+
Sbjct: 3648 WLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3707
Query: 405 CRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQFNSDI-----------QKLLE 451
R+ +E ++E N R+ +S I K + + +QF+ +KL+
Sbjct: 3708 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3767
Query: 452 PLEAEIQQGVNLKEEDFNKDMNED---NEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 508
+ ++Q + K + ++ + +L++ G + ++E K + +K K
Sbjct: 3768 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLD 3826
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP------ 562
+ ++ + + S+R + Q+ ++L L + + ++ LP P
Sbjct: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
Query: 563 -----RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 617
+ R+++E+ E + +++N Q LS G +++ + + +I+
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE 3945
Query: 618 KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 677
++ A + + T D LE L + +S + ++++ ++
Sbjct: 3946 ---DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
Query: 678 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 737
+ D E L E+LK + + SG D S K +Q+ L Q+
Sbjct: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQM 4049
Query: 738 DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-------- 789
F WE ++ + ++R+ + +E +F D + + + F+R + P
Sbjct: 4050 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4109
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 849
+ E A+ ++E DG+ + +V L G E+I + D I+++ + LN W
Sbjct: 4110 QQQEAAET---IREEIDGLQEELDIVINL---GSELIAACGEPDKPIVKKSIDELNSAWD 4163
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQ 908
+ K DR +LEE ++Q L W++ A +AS+ + +K+++E+
Sbjct: 4164 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223
Query: 909 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALP 966
+K E +Q +++LN +L EE DK +++ L + L W + +
Sbjct: 4224 LKQFKSEAYQQQIEMERLNHQAELLLKKVT---EESDKHTVQDPLMELKLIWDSLEERII 4280
Query: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
+Q ++E + LGQ + L++L L WL+ L Q G E E+
Sbjct: 4281 NRQHKLEGALLALGQFQHALDEL-------LAWLTHTEGLLS--EQKPVGGDPKAIEIEL 4331
Query: 1027 A--------VQAKQPDVEEILSKGQHLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQEL 1076
A V A Q VE + G L + + ++ KLE L+ W+ V
Sbjct: 4332 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV------- 4384
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
++T K ++ +L F+
Sbjct: 4385 ------------------------------LEKTEQRKQQLDGALR----QAKGFHGEIE 4410
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
+L WL+ ++ + + + + G E E + E + + L+ Q + +
Sbjct: 4411 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4470
Query: 1197 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 1256
+ A T I I ++ +W+ V+ L R+ +L E L + ++ + ++ L QA
Sbjct: 4471 CP-KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529
Query: 1257 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
L +D + +I E K A ++ + + + L D +
Sbjct: 4530 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4589
Query: 1317 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 1376
+ ++ + W + +R+ ER +L++ + +QF K + WL E+E + +
Sbjct: 4590 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD------S 4643
Query: 1377 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 1436
+ + D +K + Q ++ Q + A VY + + + +DD + L L
Sbjct: 4644 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4703
Query: 1437 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 1496
+ KW + KS+ ++ LE + + +LQ L+ WL + +L+ P+ GD
Sbjct: 4704 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL 4763
Query: 1497 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 1556
V D H+AF++EL + ++ L + REL E +++
Sbjct: 4764 VMNLIDNHKAFQKELGKRT-------------------SSVQALKRSARELI--EGSRDD 4802
Query: 1557 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 1616
+ ++ Q +E++T WE + S Q +++ L + +E L L +AE
Sbjct: 4803 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4862
Query: 1617 QPVGD------LLIDSLQDHLEKVKALRGEI 1641
+ D LID ++ ++K++ R E+
Sbjct: 4863 GVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4893
Score = 213 bits (541), Expect = 2e-54
Identities = 318/1675 (18%), Positives = 668/1675 (39%), Gaps = 181/1675 (10%)
Query: 12 KKAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK-- 68
+K+ R +LL+Q++ +A+ E + L+ DK + D Q+++
Sbjct: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3569
Query: 69 IQSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN----- 122
+Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3570 LQEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3627
Query: 123 FEQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 172
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K
Sbjct: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNK 3687
Query: 173 SEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM 232
+ ++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
Query: 233 RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 292
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
Query: 293 ALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
Query: 352 IQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3868 TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3927
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ-- 459
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3928 S----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983
Query: 460 ---GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQ 507
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 508 QLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR- 563
L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
Query: 564 DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFA 620
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
Query: 621 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 680
+ +I + EE M + Y + V + L +
Sbjct: 4164 SLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPI 4210
Query: 681 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDF 739
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4211 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4271 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEI 4329
Query: 800 YLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS 856
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
Query: 857 DRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVE 914
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCA 4448
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIE 973
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4449 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLE 4505
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---A 1027
+ + L+D + WL+ L + ++P+ F + E ++
Sbjct: 4506 EALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4558
Query: 1028 VQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLA 1084
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4559 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------- 4611
Query: 1085 PGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL 1144
SL F+ AW++L +WL
Sbjct: 4612 -----------------------------------SLDDARKRAKQFHEAWSKLMEWLEE 4636
Query: 1145 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 1204
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4637 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL 4696
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 1264
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4697 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4756
Query: 1265 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4757 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELST 4815
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLL 1381
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4816 RWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL 4875
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
D KE MK+ ++ + E+ T + + ++ D ++ + + +
Sbjct: 4876 IDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRAR 4925
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQK 1499
+ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
Query: 1500 QNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQ 1542
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYP 5045
Query: 1543 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5046 SGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
Score = 206 bits (525), Expect = 2e-52
Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 78
K L Q + E S E++T K+ + Q +E I L S
Sbjct: 2951 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3010
Query: 79 SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 124
S + + +++ Q + Q+D+A++ QD+ ++ + Q+ +
Sbjct: 3011 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3070
Query: 125 QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q++ E L+ E L ++ + E +Q Q
Sbjct: 3071 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3130
Query: 164 LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 222
K L + + + KT + ++ ++T + + + AL N+L + R++Q+
Sbjct: 3131 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190
Query: 223 EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 281
E +K + ++ + L + + V ++ ++ K QK EIE +
Sbjct: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3250
Query: 282 VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 339
+ + +G+ L K + +E L +N+ W + + + L E H
Sbjct: 3251 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3310
Query: 340 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 399
F ++ + W++ + L+ + +K P + V+K E ++ +D R ++
Sbjct: 3311 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3367
Query: 400 NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 451
G+ EP Q+S L+ R+ A+ ++ +T ++LE + Q+ E
Sbjct: 3368 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3422
Query: 452 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 509
LE + +++ N + ++E + + L+ I + K + + I Q L
Sbjct: 3423 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3482
Query: 510 LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 568
KD+ + L+ S WY + + ++ + L E DE ++
Sbjct: 3483 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3536
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
E+ K +L+ EGL + + + V I L K + ++ LN
Sbjct: 3537 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3589
Query: 629 QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 681
++ T +E +++ + ++ Y T L T++ + L++ + L++ +LC
Sbjct: 3590 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3649
Query: 682 -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+E + K EE+ K +K + + +D ++ +A L+ R
Sbjct: 3650 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3709
Query: 728 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 785
L++ +++ + ++ V+ + D ++ + ++F W+TE E+ L
Sbjct: 3710 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3769
Query: 786 -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
++ ++ A+ + K I + + ++ L +G +I+ S+ + +++KL +
Sbjct: 3770 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3828
Query: 845 NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 903
+ +C+ S+R +LE ++++++F E WL E +I S +P + + L+
Sbjct: 3829 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3888
Query: 904 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 963
++ E+ + L E + + + ++N+TG +L +SP E ++ K + + ++
Sbjct: 3889 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3945
Query: 964 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1022
+ ++ ++ I Q K++ + E L ++ L P E+ + +E + +
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4003
Query: 1023 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1076
+ ++ QP E + +G+ + T + V+ KL+ + W+ ++ L++E
Sbjct: 4004 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4063
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
AK +L+V LA+ + W
Sbjct: 4064 EAK------------------------------------------LLDVMELAE--KFW- 4078
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1193
D +SL+ IK + + DLED I+ ++K Q+ + + + L+E + NL
Sbjct: 4079 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4135
Query: 1194 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1250
++ + + I+ I+ + + WD + + ++R +L E ++ + Q+ + +
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4195
Query: 1251 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1310
+ A KL S ++ ++++I E KQ + Q Q ++ N A LL+ + +
Sbjct: 4196 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255
Query: 1311 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1369
D V + W S+ +R+ R+ LE L QF L++ LAWLT E
Sbjct: 4256 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4313
Query: 1370 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1429
+ ++ + D K ++ + + LQ ++ AH +++ ++ S G ++A
Sbjct: 4314 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4368
Query: 1430 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1489
LQ +L+ +N +W + +K+ + L+ + Q K H +++L WL + L P
Sbjct: 4369 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4428
Query: 1490 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1549
+GG ++Q +VH + KE S ++ + L P + Q+ L
Sbjct: 4429 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4486
Query: 1550 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1609
+WE + + + K++E L E + + L QA
Sbjct: 4487 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4528
Query: 1610 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1668
E + + +P L++D++ +++ K E+ +E + ++ L +
Sbjct: 4529 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4586
Query: 1669 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1699
+ + L + +RW+ + + +R R L +A +
Sbjct: 4587 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4618
Score = 198 bits (503), Expect = 6e-50
Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 77
++Q+I + + + L + + L+ +D +L++ +A M Q+ AQK++ ++ +
Sbjct: 2645 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2704
Query: 78 ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 122
+ EE K ++ + S DV QK V
Sbjct: 2705 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2764
Query: 123 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 182
F+Q ++ + LD K S + +V++S + + K+L+ E I G
Sbjct: 2765 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2824
Query: 183 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 242
++ K Q L ++ +K +++ +V ER+ +L++ L+ + K ++++ L W
Sbjct: 2825 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
Query: 243 LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 301
+ L + + ++ P+ ++ +A K+ QKE+++ ++ + +L +V
Sbjct: 2885 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
Query: 302 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 361
+ +V D+ L VT + L + + F + + + A LD
Sbjct: 2943 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3002
Query: 362 EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 416
+ Q + +L+ + L ++ +VD + A +L+ D V Q+ +
Sbjct: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3062
Query: 417 NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
+ +S ++ K L+ + F + I+++ + ++ + + +
Sbjct: 3063 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3122
Query: 475 DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 520
+ T+K L++ DN + T+E + + IK+ L L + N L D
Sbjct: 3123 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3181
Query: 521 RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 568
R+Q R++ +E + ++Y ++ LL+ ++ E+ + ++ + + K+
Sbjct: 3182 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3241
Query: 569 -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 622
KE LQ K++++N + +GL + A +E ++ RW+ + K AQ
Sbjct: 3242 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3298
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+L A +H R + + + +++ E+L+ +
Sbjct: 3299 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3337
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
+F+ + Q + K ++ L +++I + +A P ++VK+ + LS LD +WE
Sbjct: 3338 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3397
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 801
+ + R + + ++FH ++ N+WLT E+ L + P + +K + +
Sbjct: 3398 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3456
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+D I + + G+ + SS+ D ++Q KL + + E+ ++ R
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3516
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
+ L++ F D E + WL E D ++ + ++ + L ++ ++++L E++ L
Sbjct: 3517 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3576
Query: 919 R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 963
R Q +L L TG VL+ + ++ KL + +T Q ++++R
Sbjct: 3577 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3636
Query: 964 ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 996
L E+ E Q+ K+L + K + L + LN +
Sbjct: 3637 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3696
Query: 997 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1051
LL L P R LE + E V +T + K +++ + + Q + A
Sbjct: 3697 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3753
Query: 1052 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1090
T+ L D+ E + LQ + + D+ L T
Sbjct: 3754 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3813
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1147
Q++ V+ I ++ L LE A + N+ W EL WL+
Sbjct: 3814 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3872
Query: 1148 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
+I + E + + + + + + + +P ++++ L + + I
Sbjct: 3873 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3930
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1266
++ + +++E ++ R L+E + STQ+ ++ +Q+L +E ++ P
Sbjct: 3931 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 3987
Query: 1267 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1323
V+ I+++I+E K ++ D+ + Q + +++ R D + + ++
Sbjct: 3988 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4047
Query: 1324 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
W +IH V EREA L + L ++F D + + + + L+D +
Sbjct: 4048 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4107
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
++ + E ++ +++ G ++ D+ NL L + G D ++++ +D +N
Sbjct: 4108 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4160
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
W L K + LE + + LQ + W+ + +L+ +PIG D V++Q
Sbjct: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
+ + FK E +Q +E +E+L + L + ++ +
Sbjct: 4221 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4261
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
+ E+ W+ L + Q K++ L L + Q A DEL L E + +PVG
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1679
+++ L K L+ ++ + V VN L NL + LE LN R
Sbjct: 4322 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380
Query: 1680 WKLLQVAVEDRVRQLHEAHR 1699
W+ + E R +QL A R
Sbjct: 4381 WQNVLEKTEQRKQQLDGALR 4400
Score = 191 bits (486), Expect = 6e-48
Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)
Query: 33 KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 88
++L +E++ K+L A +A +A +M ++ DL + LE + K N+
Sbjct: 3119 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3178
Query: 89 GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 148
+ AQ Q++ K+L++ F +L+E ++L + + H +
Sbjct: 3179 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3225
Query: 149 VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 206
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
+ L KV +R QL++ L + + + L W+ T+ + + + ++
Sbjct: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3345
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 325
+ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++AE
Sbjct: 3346 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3405
Query: 326 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 383
L + F + ++ + +W+ + L E Q E+ + + KA +DI
Sbjct: 3406 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3465
Query: 384 RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 438
Q+ ++++R D + +V+ ++ F+ + + I+ + S E
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3517
Query: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 496
L Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3518 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3571
Query: 497 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 556
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K L
Sbjct: 3572 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
Query: 557 ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 614
+ R++ EL K E+ + + + L + A+ A + +L K +
Sbjct: 3629 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3685
Query: 615 IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3686 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3744
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 728
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804
Query: 729 ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 774
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3805 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3864
Query: 775 -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
Query: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 890
SI QEK + + + ++ + + R L+E + ++F +++ + LE + +
Sbjct: 3925 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983
Query: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 948
P + +++KE++ + K + ++ Q + + L + G ++ + + ++ ++
Sbjct: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 949 NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1006
+KL Q W + + E+ EA++ D+ +L +K +H L++ + ++
Sbjct: 4044 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4094
Query: 1007 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1058
+ P + Q+ E A + Q +++ +++ G L +P VK+
Sbjct: 4095 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4154
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
+++L+S W ++N+ ++ I KLE
Sbjct: 4155 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4179
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
+ A + + DW+ + + S + DLE + + I + K + Q
Sbjct: 4180 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
Query: 1179 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1238
++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293
Query: 1239 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1298
Q+ A +E L L K AI+ ++ + L D+ Q+ V+ N
Sbjct: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353
Query: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4413
Query: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
WLT+ E + + L + KE + ++ EA + Y +L + Q++
Sbjct: 4414 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4467
Query: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
L S + + + ++N+ KW + K ++ LE + + H SLQ+ + WL
Sbjct: 4468 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4526
Query: 1479 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1535
+ L+ + V Q D H+ F E+ + I+ +T ++ F +Q +
Sbjct: 4527 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4586
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1585
++ L + + R + V + L RK+A++ + W KL +W +
Sbjct: 4587 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4637
Query: 1586 DETLERLQELQEATDELDLKLRQ 1608
+++L+ E+ D++ +L Q
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQ 4660
Score = 161 bits (407), Expect = 8e-39
Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)
Query: 30 ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 88
ETEK L + + D+ A K ++ + I + S H+I ++ Q
Sbjct: 3760 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3819
Query: 89 G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 146
K+ +VL D + + ++ Q N F + +E L E + + L
Sbjct: 3820 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3879
Query: 147 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 206
++E E ++ Q L + ++E K ++ + KTG Q+++ E + E+ A
Sbjct: 3880 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3938
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
Y+++ V +R L++ + S + +++ + E L L + ++ + +
Sbjct: 3939 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 321
++ K ++EK + +++ + GE + G + V+DKL + W + +
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 374
EE LL+ + E F DH++ + DT + + P +Q+++ +
Sbjct: 4059 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
Query: 375 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 432
++ E++ ++ ++D + + L+A G+ + +V+ I ELN + +++ K K
Sbjct: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
Query: 433 SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 472
++ Q+ +Q + LE ++ +I++ K E + + +
Sbjct: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ L + + L +++T+E + ++ L+ ++L++ R+ K
Sbjct: 4237 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4290
Query: 533 HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 584
Q++ D+LL L E L+ + K EI+ ++ + + A
Sbjct: 4291 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4350
Query: 585 VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 635
V + L E A Q +L ++RW+ + K Q ++ L A+ H E
Sbjct: 4351 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4410
Query: 636 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 695
+ +T+ ++ P L E EQL ++CA FE +EE+ K
Sbjct: 4411 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4458
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 755
++ QQ R K+A + + ++ L +WE V +R+ +
Sbjct: 4459 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4504
Query: 756 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 809
+ ++ FH ++ F WLT+AEQ L P ++ ++K + E+
Sbjct: 4505 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4561
Query: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869
R+ ++ L+ TG + S K D +++ L S+ RW++V ++L +R + L++ +
Sbjct: 4562 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4620
Query: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 928
+F ++ + WLEE++ LE + ++K +L Q K + L + + N
Sbjct: 4621 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680
Query: 929 TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 988
TG + ++ ++ KL++ L + +W + E+Q ++E + GQ L+
Sbjct: 4681 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4739
Query: 989 LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1048
L + WL + QL +QP G D+ I D + K L K
Sbjct: 4740 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4781
Query: 1049 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+ Q +KR +L S W V +QEL + +TV ++
Sbjct: 4782 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4824
Query: 1103 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1161
T+ E A+ + E +F+ L +WL+ +Q ++ V+ D +
Sbjct: 4825 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871
Query: 1162 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1215
+ +I + K M+ LE++R +L + T + + T+ + TII R E +
Sbjct: 4872 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4931
Query: 1216 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1256
+ Q+ L + +Q+L E L QW E EE + ++ + +
Sbjct: 4932 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4991
Query: 1257 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1310
+E VD K+T+T K+ A D Q+++ V A Y +
Sbjct: 4992 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
Query: 1311 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1359
++ +N + W+ + ER L + L++ F D+ +K++
Sbjct: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5107
Query: 1360 WLTEAET 1366
W+ ++
Sbjct: 5108 WMNHKKS 5114
Score = 159 bits (402), Expect = 3e-38
Identities = 324/1735 (18%), Positives = 696/1735 (40%), Gaps = 227/1735 (13%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 71
K +QK+ + I + +E + E+L I LA + DK+ + + +++++
Sbjct: 1468 KPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKH-GDKMTDEERNELEKQVKT 1520
Query: 72 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL--- 127
S+ + E K Q + + V + + ++ Q+ K + + E RL
Sbjct: 1521 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1580
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
QE+ MI D + L ++K QE +Q + ++L+EV E +K +
Sbjct: 1581 QEAFMIGDGT-VELKKYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE--- 1630
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
K E+ +++++ K+ +L K + K++L+K + + K TE +AA
Sbjct: 1631 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVK 1684
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVE 306
++ +E + + W K+ E+ H + I + G + GK E
Sbjct: 1685 QLEESKTKIENL-------LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE 1737
Query: 307 DKLS--LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-E 360
D+++ LL ++ +E NL +YQK ++ + II A LL+ +
Sbjct: 1738 DEVNGNLLETDVDGQVGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQ 1795
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
+ P++KE + K +K +++ ++ ++ M ++ ++ + + +
Sbjct: 1796 GQYLSPEEKEKLQKNMK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADY 1846
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
H ++ + L+ LE DI L+ L+ +++ F++D+ ++G +
Sbjct: 1847 TEFEHWLQQSEQE--LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDL 1894
Query: 481 KELLQRGDNLQQRITDERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKAL 529
+ + G+ + + KR+ K+ Q+ L + + L S+
Sbjct: 1895 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1954
Query: 530 EISHQWYQYKRQADDLLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKK 579
++ ++ Y+ + LL L E + L EP R + K + ++ ++
Sbjct: 1955 DLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQ 2014
Query: 580 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 639
+ +++ AE L + A ++ P + + K +I ++ + ++ E+ +
Sbjct: 2015 VAVEKLKKTAEVLLD--ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQI 2068
Query: 640 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIK 698
+T + ++ L + +V +L E Q+ LN+ L +D+ + L+
Sbjct: 2069 TLTRSLSVQDGL--DEMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDI 2121
Query: 699 DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRS 758
Q S I+ ++ K +++ P LQ + L ++ + + +K+ + +
Sbjct: 2122 AGRQSS---INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2178
Query: 759 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 818
K F + +L Q L + +P + + Y++E + + + L
Sbjct: 2179 KTKVELFENLSEKLQTFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVL 2237
Query: 819 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE 878
++ +EI +D +++ EK +L+ +++E+ + ++K+ + + L FQ +
Sbjct: 2238 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
Query: 879 FVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVS 936
W++E I + L + LE K L E+ L+ ++++N +G + L+S
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
Query: 937 APISPEEQDKL----------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK- 984
A +P + E T W K ++ + +I +DLG L K
Sbjct: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417
Query: 985 ----------KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP- 1033
KL+ +E+ + ++ WL + + Q P D + + V+ +
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSF 2475
Query: 1034 ---------DVEEILSKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQP 1081
V+E+ K L +E P T K+ L ++ S+W+ +N+L + + K
Sbjct: 2476 EAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2535
Query: 1082 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1141
+ + LT Q + Q +V KE +S L
Sbjct: 2536 ESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGP------------------------ 2567
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
LS+ ++ +QR V + +Q+ R+PQ E+L A Q + ++
Sbjct: 2568 LSIDPNMLNTQRQQV-------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDP 2614
Query: 1202 A-RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+ R I+ +++ + +WD + L +R +++ + STQ+ L KL
Sbjct: 2615 SLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS 2674
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKV 1315
S DA+ +++ +++ ++++Q + + VA DL+ + +Y A+ +R++
Sbjct: 2675 SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQL 2734
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
I ++ + V ++A +H+ QQ D F AWL + N +
Sbjct: 2735 EGILKSFKDVEQKAENHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPIS 2790
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
K +LE L+K +D + A + +Y + +L +GS+ A LQ +L
Sbjct: 2791 AKLDVLE------SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQL 2843
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIG 1491
+ + W K+ + L+ S ++ + ++ L W+ + L P
Sbjct: 2844 NTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE 2903
Query: 1492 GD-----FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
G+ ++QK+ D H L ++S E + +T++ ++K+ +
Sbjct: 2904 GENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2963
Query: 1547 LPPEERA-QNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEA 1598
L ++ +N+T+ K+ +EV+ E K L A Q I ++L + L LQ
Sbjct: 2964 LHSKKFCLENMTQKF-KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3021
Query: 1599 TDELDLKLRQAEVIKGSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1648
L Q ++ K Q DL++++ D L +V+ + E + L + V
Sbjct: 3022 QKSLQALKHQVDLAKRLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3073
Score = 149 bits (376), Expect = 3e-35
Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)
Query: 47 KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 104
K L+ IA D + + +E + +Q ++S ++++E++KK + +A +L + Q
Sbjct: 1983 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2042
Query: 105 KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 154
K L D+ ++ K N + L S + LDE+ + +E+ EQ V
Sbjct: 2043 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2102
Query: 155 -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 209
Q ++ + L + ++ +S + + + ++ ++ L ++ L ++
Sbjct: 2103 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2162
Query: 210 ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
E AK+ E K ++E LS K++ + T+ A T++++ + E +
Sbjct: 2163 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2219
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 322
+ + +K +E LK I+ G L + LV +K + L+ + +
Sbjct: 2220 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2273
Query: 323 AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 369
+E + Q+ ++ F V + W I+Q A+ L E K Q+
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2333
Query: 370 EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 402
+ LK + + L ++ V + T AN+G
Sbjct: 2334 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2393
Query: 403 ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 446
+ L++ +I+ELN + + + + A + L+++ + +
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453
Query: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Q+ P + E + + + F ++ + N V+EL + L + D + K
Sbjct: 2454 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2512
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 565
+ +K L L R++K E S+ Q++ L + L + E ++ L P D
Sbjct: 2513 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2572
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+ +++Q +E + Q E L+ G + P + + +
Sbjct: 2573 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2622
Query: 626 NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 682
A + T + +++ D ++ + V ST Y + + +S L +++ L++ +
Sbjct: 2623 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2681
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 740
+ + +Q E+ + +K +QQ +I + + + +AL VK + ++L Q
Sbjct: 2682 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2733
Query: 741 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 800
E + K +KD + + + V+ + F Q + + +L + +N H
Sbjct: 2734 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2792
Query: 801 LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 850
L L+ I + +TL A GE ++ ++ ++ + LQ +L ++ W
Sbjct: 2793 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2852
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 907
KQ+ +R+ +L+E +++ + W+++ +N+ I L+P + + KL
Sbjct: 2853 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2911
Query: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 967
K L +E+ G+++ LN T +L I E ENK
Sbjct: 2912 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2951
Query: 968 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1027
L +K++ + EQL+ L + + + + + ++E + ++
Sbjct: 2952 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 2993
Query: 1028 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+Q D+ + L + K Q ++ L+ L + RL Q+L + D
Sbjct: 2994 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3048
Query: 1088 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ T V L + + + + +S+ E S L ++ + F E+ +
Sbjct: 3049 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3104
Query: 1146 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1205
D + S + D E + KQK T++ ++ LE L+ + N NKT T
Sbjct: 3105 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3156
Query: 1206 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1257
T +E + Q +++ + Q R +Q+ +K ++ +E +L +A
Sbjct: 3157 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3216
Query: 1258 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1315
ES + I +++ K K+ + Q N L L++ + + T+ +
Sbjct: 3217 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
+++NA W++++K+V++R A L+E +F LE L+W+ + E A
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3331
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
+K E K VK +++ + LQ ++ + +KI + E +D +L ++L
Sbjct: 3332 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3389
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1495
++ +W L K+ LE S ++ H +L+ L WL + L PIG
Sbjct: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449
Query: 1496 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1550
+++Q H+A + ++ + +S +++++ + + + ++ + + + +
Sbjct: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
Query: 1551 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1605
E++ + + LL++ E + +W ++ + L +L +T+ L +L+
Sbjct: 3510 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3568
Query: 1606 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1651
+ Q +++ Q V L++ L QD LE +KA +I L +V+
Sbjct: 3569 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3627
Query: 1652 NDLARQL 1658
+ A QL
Sbjct: 3628 LEQALQL 3634
Score = 129 bits (324), Expect = 3e-29
Identities = 348/1814 (19%), Positives = 706/1814 (38%), Gaps = 343/1814 (18%)
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDV-SMKFRLFQK 119
++ +E ++++ DL + EE + + S+++V + + V SM K
Sbjct: 1111 KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK 1170
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE--- 176
L+ ++ VK++ ETK E+E V + N+ NL +L + +SEV+
Sbjct: 1171 LKTVNLVLKNTQAAEALVKLY----ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226
Query: 177 MVIKTGRQIVQKKQ--------TENPKELD-----ERVTALKLHYNELGAKVTERKQQLE 223
V +QK + T ++LD E+ L + + ++ R + LE
Sbjct: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1286
Query: 224 KCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
K + R + L +W+ +E T+R E P N
Sbjct: 1287 GIGKSLKYYRDTYHPLDDWIQ--QVETTQRKIQENQPEN--------------------- 1323
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ L T L +++ LV + + + S AE++ + +Y+ T+
Sbjct: 1324 -------SKTLATQLNQQKMLVSE-IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1375
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
VD K ++ +++ Q D++ + E D+R + + + GD
Sbjct: 1376 VDSQQKSPVK---------RRRMQSSADLIIQ---EFMDLRTRYTALVTLMTQYIKFAGD 1423
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE-----IQ 458
++L E + S + + KEL+++ S+I K L+ E +
Sbjct: 1424 SLKRLEEEEKSLEEEKKEHVEKA----------KELQKWVSNISKTLKDAEKAGKPPFSK 1473
Query: 459 QGVNLKEEDFNKDMNEDNEGTVKELLQR-GDNLQQRITDERKREEIKIKQQLLQTKHN-- 515
Q ++ +E K+ + T++ L + GD ++TDE +R E++ + + LQ +N
Sbjct: 1474 QKISSEEISTKKEQLSEALQTIQLFLAKHGD----KMTDE-ERNELEKQVKTLQESYNLL 1528
Query: 516 ---ALKDLRSQRRKKALEI-----SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK 567
+LK L+ + +++ + + +YK + + L E +L E
Sbjct: 1529 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAF---M 1585
Query: 568 IKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI--ESKFAQFRRL 625
I + EL+K + + +++ +G S A V+ T+ L + ++ E K ++L
Sbjct: 1586 IGDGTVELKKYQSKQEELQKDMQG-SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1644
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH-------VSQALLEVEQLLNAPD 678
N A+I E + + E E+ V +T + E T + ++ ++E LL+
Sbjct: 1645 NEAKIKC---EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1701
Query: 679 LCAKDFED------------------------LFKQEESLKNI------------KDSLQ 702
KD E + +++E N+ +++L
Sbjct: 1702 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1761
Query: 703 QSSGRIDIIHSKKTA-------ALQSA-----------TPVERVKLQEALSQLDFQWEKV 744
Q ++ H K + A QSA +P E+ KLQ+ + +L +E
Sbjct: 1762 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1821
Query: 745 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE---NWEHAKYKWYL 801
+ + E+ +F D F WL ++EQ L + N K K
Sbjct: 1822 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1881
Query: 802 KELQDGIGQRQTVVRTLNATGEEIIQQS---SKTDASILQEKLGSLNLRWQEVCKQLSDR 858
+D I + + R + +G +++ + SK D + + + Q +DR
Sbjct: 1882 SFSEDVISHKGDL-RYITISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDR 1938
Query: 859 KKRLEEQKNILSEFQRDLNE-----------FVLWLEEADNIAS------IPLEPGKEQQ 901
+ L + N+L +DL + + L+ + AS I ++P +
Sbjct: 1939 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP---KN 1995
Query: 902 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA-----PISPEEQDKLEN------- 949
L+ +LE+ K L ++ +Q +++L +T VL+ A P + Q L++
Sbjct: 1996 LQRQLEETKALQGQISSQQVAVEKLKKTA-EVLLDARGSLLPAKNDIQKTLDDIVGRYED 2054
Query: 950 ----------KLKQTNLQWIKVSRALPEK---QGEIEAQIKDLGQLEKKLEDLEEQLNHL 996
KL+ T + + V L E G +E+ +K+ GQ+ L++ ++
Sbjct: 2055 LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN 2114
Query: 997 LLWLSPIRNQLEIYNQPNQEGPFDVQETE----IAVQAKQPDVEEILSKGQHLYKEKPAT 1052
++ I + N N++ ++ T+ ++QAK D+ S+ H +KE A
Sbjct: 2115 IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA- 2173
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
K+E+L ++ + L ++L+ LT + P + VT ++Q + +
Sbjct: 2174 -----KMEELKTKVELFENLSEKLQTFLETKTQALTEVDV-PGKDVTELSQYMQESTSEF 2227
Query: 1113 SK----LEMPSSLMLEVPA--LADFNRAWTELTDWLSL----LDQVIKSQRVMVGDLE-- 1160
+ LE+ SL+ E+ + L E T+ LS ++ IK ++ V +
Sbjct: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2287
Query: 1161 -DINEMIIKQ-KATMQDLEQRRPQLEELITA---AQNLKNKTSNQEARTIITDRIERIQN 1215
D ++++K K+ +++ ++ P ++ A ++L++ QE ++ T I+++ N
Sbjct: 2288 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2347
Query: 1216 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL---GQARAKLESWKEGPYTVDAI 1272
+ L + + + A + VL G A E W T +I
Sbjct: 2348 SGISLCN--------LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT--SI 2397
Query: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
+K +T+ +DL LL+D A+ ++ +
Sbjct: 2398 KKDMTDISHGYEDLGL--------------LLKDKIAE------------------LNTK 2425
Query: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
+S+ + A EE+ ++Q WL + TA Q D++ VK ++
Sbjct: 2426 LSKLQKAQEESSAMMQ-----------WLQKMNKTATKWQQTPAPT----DTEAVKTQVE 2470
Query: 1393 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
Q + + E++ + + L + ++L + +A ++ L ++ KW EL + +++
Sbjct: 2471 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2530
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 1512
+ LE SS+ + +L WL K+ +S P+ D + Q + +E
Sbjct: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2590
Query: 1513 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 1572
T++P EQ + + P E P ++ ++++Q V +W+
Sbjct: 2591 TRKPQY------------EQLTAAGQGILSRPGEDP------SLRGIVKEQLAAVTQKWD 2632
Query: 1573 KLNLHSADWQRKIDETLER-------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
L +D ID+ + + L+ L + +LD KL + + S P D
Sbjct: 2633 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV--STHP------D 2684
Query: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ--LSPYNLSTLEDLNTRWKLL 1683
++ LE + ++ EI K+ + L L+ L + L LE + +K +
Sbjct: 2685 AMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV 2744
Query: 1684 QVAVEDRVRQLHEA 1697
+ E+ V+ L A
Sbjct: 2745 EQKAENHVQHLQSA 2758
Score = 104 bits (260), Expect = 9e-22
Identities = 306/1742 (17%), Positives = 660/1742 (37%), Gaps = 286/1742 (16%)
Query: 97 LSQIDVAQKKLQDVSMKFRLFQKPANFEQ---RLQESKMILDEVKMHLPALETKSVEQEV 153
+ Q++ Q+K+Q+ +P N + +L + KM++ E++M
Sbjct: 1306 IQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMK------------- 1344
Query: 154 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPK----------------EL 197
QS+++ C + S + E+ T R +V +Q K +L
Sbjct: 1345 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 198 DERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEM-NVLTEWLAATDMELTKR 253
R TAL Y + +R ++ EK L+ +K E L +W++ L K
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL-KD 1462
Query: 254 SAVEGMP----SNLDSEVAWGKATQKEIEKQKVHL-----------KSITEVGEALKTVL 298
+ G P + SE K Q Q + L + E+ + +KT+
Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
Query: 299 GKKETLVEDKLSLLNSNWIAVTSRAEEWL--NLLLEYQKHME--------TFDQNVDHIT 348
L + L L + + + EE + EY++ ++ T ++ + H
Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKR-LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
++I T+ E KK Q K++ L++ ++ + V +T + +
Sbjct: 1583 AFMIGDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIP----------------LKELEQFNSDIQKLLE 451
L+E +++E + ++ + + K + +K+LE+ + I+ LL+
Sbjct: 1639 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1698
Query: 452 PL---------------EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 496
L + Q G + +E D + E++E LL+ + Q T
Sbjct: 1699 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN-GNLLETDVDGQVGTTQ 1757
Query: 497 E---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLK---- 547
E ++ +++K + + + ++H A+ + +Q + LE Q+ + K + +K
Sbjct: 1758 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
Query: 548 ----CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 603
L + EKK+ ++E +++ D + + + L ++ E L +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEE--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM 1874
Query: 604 TQIQLSKRWRE-IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 662
T+++ K + E + S R + + + + ++ S ++ H
Sbjct: 1875 TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH 1934
Query: 663 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESL---------------------------K 695
+ + N KD D ++ E K
Sbjct: 1935 ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK 1994
Query: 696 NIKDSLQQ--------SSGRIDIIHSKKTA-----ALQSATPVERVKLQEALSQLDFQWE 742
N++ L++ SS ++ + KKTA A S P + +Q+ L + ++E
Sbjct: 1995 NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN-DIQKTLDDIVGRYE 2053
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKWYL 801
++K +R + ++ + + W+ E L++ Q+P N A
Sbjct: 2054 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN-STALQDIIS 2112
Query: 802 KE--LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+ I RQ+ + +N ++ ++ + + AS LQ K+ L+ R+ E + +
Sbjct: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVE 914
++EE K + F+ + +LE + PGK+ Q ++E + +
Sbjct: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2232
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
L + +LK+++ G P DK K NL S+ E + I+
Sbjct: 2233 HLEVLHSLLKEISSHGLP-----------SDKALVLEKTNNL-----SKKFKEMEDTIKE 2276
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN------QEGPFDVQETEIAV 1028
+ + + +++L+ + + L W+ ++ I QP+ + D ++ +
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV-QPSFGAEDLGKSLEDTKKLQEKW 2335
Query: 1029 QAKQPDVEEILSKGQHLYK-------EKPATQPVKRKLEDLSSEWKAVN-------RLLQ 1074
K P+++++ + G L A VK L+ E A N + L
Sbjct: 2336 SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT 2395
Query: 1075 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 1134
++ D++ G +G + + TK + + K + SS M++
Sbjct: 2396 SIKKDMTDISHGYEDLGLLLKDKIAELN----TKLSKLQKAQEESSAMMQ---------- 2441
Query: 1135 WTELTDWLSLLDQVIKS--QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192
WL +++ Q D E + + + K+ +L+Q +++EL
Sbjct: 2442 ------WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2495
Query: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252
L + + + I ++W E+ + +R+Q+L E + TQ+ + + +Q L
Sbjct: 2496 LLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL 2555
Query: 1253 GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD 1310
+ + GP ++D T+ +Q+ L+++ T L A + + +
Sbjct: 2556 VEKELMVSVL--GPLSIDPNMLN-TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE 2612
Query: 1311 DTRKVHMITENINA---SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
D ++ E + A W S+ ++S+R +++ Q+ L L++ +
Sbjct: 2613 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2672
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
++ L +T + + + + +++ ++ Q + +I+ + +L ++ E
Sbjct: 2673 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--- 2729
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLE---ASSDQWKRLHLSLQELLVWLQLKDDE 1483
L R+L+ + + ++ +K+ N HL+ ASS Q++++ Q WL K +E
Sbjct: 2730 ----LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEE 2782
Query: 1484 LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQE 1543
++ PI ++ H+ F + L + + T+ L + +G EK
Sbjct: 2783 QNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEK---- 2836
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL- 1602
L+ Q + T W+ N + + K+ E+LE+ + +E + L
Sbjct: 2837 --------------AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 2882
Query: 1603 ---DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
D E IK P ++ + K+K+L+ E+ V +N+ A L
Sbjct: 2883 PWIDKCQNNLEEIKFCLDPAEG------ENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2936
Query: 1660 TL 1661
++
Sbjct: 2937 SV 2938
Score = 94.7 bits (234), Expect = 9e-19
Identities = 322/1853 (17%), Positives = 708/1853 (38%), Gaps = 350/1853 (18%)
Query: 2 SARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 61
S + L+ + +K + + LL+Q++ E E ++ +Q+ L ++D+
Sbjct: 575 SLQTLKLMQIRKPLLKSSLLDQNLT---EEEINMKFVQDLLNWVDEM------------- 618
Query: 62 MPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA 121
++Q D T L ++ H + + R + +
Sbjct: 619 ------QVQLDRTEWGSDLPSVESHLENHKNVHRAIEE---------------------- 650
Query: 122 NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEM 177
FE L+E+K + E++M P T + + ++SQ LN N + L + + V
Sbjct: 651 -FESSLKEAK--ISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSR 707
Query: 178 VIKTGRQIVQKKQTENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
+ +K++ E + ER T + K ++ EL ++ ++++ ++ +++ ++
Sbjct: 708 ATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL 767
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEV 290
E + R +E + + ++ +W + ++ I++ + + +
Sbjct: 768 ENH-------------PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 814
Query: 291 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 350
EA + K+ ++ K S S+ I + +L+ E + E Q I
Sbjct: 815 KEATDYLRNLKDA-IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANL 867
Query: 351 IIQADTLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
+ +A T++ + KP+ + LK +KA + + ++ +D L N K
Sbjct: 868 MGKAKTII----QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 923
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----L 463
++ P +E + +A +EQ ++ L ++ V+ +
Sbjct: 924 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 983
Query: 464 KEEDFNKDMNEDNEGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQ 508
E D + N ++K +L Q NLQ R D E +E +++++
Sbjct: 984 NEID---RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1040
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE- 565
+ K + L+S R++ E + Y + + L C D + +++ + P RD+
Sbjct: 1041 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDL 1099
Query: 566 -------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 618
+ +++ +EL++ K++L + + E AA + PT
Sbjct: 1100 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT-------------- 1145
Query: 619 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLN 675
+R E +V+ ++M ++ + STY+ ++ V+ L E L+
Sbjct: 1146 --------------LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1189
Query: 676 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQ 731
+ + E + + +++N+ +L+Q +D + H+ + ++ + +
Sbjct: 1190 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1249
Query: 732 EALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI-------------------- 771
LDF W K + D+ VE+W+ H I
Sbjct: 1250 YKERDLDFDWHKE---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1300
Query: 772 -FNQWLTEAEQFLRKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNA 820
+ W+ + E RK Q PEN + + K + E+ Q + + Q +A
Sbjct: 1301 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1360
Query: 821 TGEEIIQQSSKTDASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRD 875
T ++ Q+ A + ++ + R + + ++ D + R +++++ +
Sbjct: 1361 TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1420
Query: 876 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 935
+ + LEE E E++ KE +E+ K L + + LK + G P
Sbjct: 1421 AGDSLKRLEEE--------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1472
Query: 936 SAPISPEEQDKLENKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ-------- 981
IS EE + +L + LQ I++ + E++ E+E Q+K L +
Sbjct: 1473 KQKISSEEISTKKEQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1531
Query: 982 ---------------LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 1021
+E+K+ ++ +E+L + L+ N+L + + G V
Sbjct: 1532 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591
Query: 1022 QETEIAVQAKQPDVEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRA 1078
+ + Q+KQ ++++ + E K +K E LS E KA + + L E +
Sbjct: 1592 ELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1649
Query: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
K L + VT + K A+ +LE S +E L
Sbjct: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NL 1696
Query: 1139 TDWLSLLD-----------QVIKSQ---------RVMVGDLEDINEMIIKQKA------T 1172
DWLS +D QVI+ + +G+ +++N +++ T
Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
Query: 1173 MQDLEQR----RPQLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQE 1222
++L Q+ + Q E++I+ Q + T + ++ + + + E++Q E++
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
Query: 1223 HLQN------RRQQLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKK 1275
H + ++ +L L++ + +A E E L Q+ +LE+ + G ++ + K
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
Query: 1276 ITETKQLAKDLRQWQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENIN 1323
+ K ++D+ + + + ++ + L+ + S D R+V ++
Sbjct: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
Query: 1324 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 1383
+RS++ + + L++ Q + LA L E TA+ E + D
Sbjct: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVD 1992
Query: 1384 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMN 1439
K ++ +++ + LQG+I + L + ++ +L + L +D +Q+ LD++
Sbjct: 1993 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIV 2049
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ- 1498
++ +L K L+ + + + L E+L W+ + L Q + + A+Q
Sbjct: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2109
Query: 1499 --------------KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+Q+ ++ ++ K E ST +++ + + E ++
Sbjct: 2110 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2169
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
L E + L +E++ T E + + E Q +QE+T E
Sbjct: 2170 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2229
Query: 1605 KLRQAEVIKGSWQPVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1649
+ EV+ + + L+++ + +K K + I KE V+
Sbjct: 2230 HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2282
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 247 bits (630), Expect = 1e-64
Identities = 345/1755 (19%), Positives = 729/1755 (41%), Gaps = 165/1755 (9%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEAQKIQSDLTS 75
KLL+++ ++ E ++ ++E + + + + A++ + +Q P E + I L
Sbjct: 2852 KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNM 2911
Query: 76 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 123
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 2912 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 2971
Query: 124 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 169
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 2972 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3031
Query: 170 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 229
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3032 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3091
Query: 230 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 289
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3151
Query: 290 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 348
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3152 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3211
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 408
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3212 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3269
Query: 409 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 456
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3270 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329
Query: 457 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 506
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3330 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3389
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 566
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3390 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3449
Query: 567 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 626
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3450 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505
Query: 627 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3506 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3560
Query: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3619
Query: 747 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 804
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 3676
Query: 805 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 857
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 3677 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 3736
Query: 858 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 916
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 3737 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 3796
Query: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 974
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 3797 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 3852
Query: 975 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 3853 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 3908
Query: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 3909 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 3952
Query: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 3953 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 3990
Query: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 3991 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4049
Query: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4050 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4109
Query: 1272 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 1331
++++ ++ + ++L + N+ W S+
Sbjct: 4110 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4169
Query: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 1391
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4170 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4223
Query: 1392 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 1451
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4224 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4282
Query: 1452 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 1511
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4283 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4342
Query: 1512 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 1571
K V +T T R L + + L E+ +W
Sbjct: 4343 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4383
Query: 1572 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 1630
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4384 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4441
Query: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 1683
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4442 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4501
Query: 1684 QVAVEDRVRQLHEAH 1698
Q +E +RQ E H
Sbjct: 4502 QTRLEAALRQAEEFH 4516
Score = 217 bits (553), Expect = 9e-56
Identities = 319/1711 (18%), Positives = 674/1711 (39%), Gaps = 190/1711 (11%)
Query: 12 KKAVRRQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 65
KK +R L++++ Q A E+ S + E L K +A KV AQ+ QE
Sbjct: 2966 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QE 3022
Query: 66 AQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 125
+ +Q L + ++E +K+ + ++ + K+L + ++ A
Sbjct: 3023 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRN 3081
Query: 126 RLQESKMI--------LDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEV--- 171
R E + L+ + L +E + V E + +Q L + +K+L +
Sbjct: 3082 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3141
Query: 172 -KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSR 230
+ + G+ + E+ + ++ ++ Y E+ K R + L++ L ++
Sbjct: 3142 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3201
Query: 231 KMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 290
++ L WL +L+K S + L + + + Q++I +K ++
Sbjct: 3202 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3261
Query: 291 G-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 349
G E LK G + +++DKL + + + +T + + L + + + +
Sbjct: 3262 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3321
Query: 350 WI--IQADTLLDESEKKKPQQKEDVL---KRLKAELNDIRPKVDSTRDQAANLMANRGDH 404
W+ ++ + L E++ K ++ K LK E + + +DS + ++ L+
Sbjct: 3322 WLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWR 3381
Query: 405 CRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQFNSDI-----------QKLLE 451
R+ +E ++E N R+ +S I K + + +QF+ +KL+
Sbjct: 3382 AREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3441
Query: 452 PLEAEIQQGVNLKEEDFNKDMNED---NEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 508
+ ++Q + K + ++ + +L++ G + ++E K + +K K
Sbjct: 3442 LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLD 3500
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP------ 562
+ ++ + + S+R + Q+ ++L L + + ++ LP P
Sbjct: 3501 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3560
Query: 563 -----RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 617
+ R+++E+ E + +++N Q LS G +++ + + +I+
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE 3619
Query: 618 KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 677
++ A + + T D LE L + +S + ++++ ++
Sbjct: 3620 ---DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISEN 3676
Query: 678 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 737
+ D E L E+LK + + SG D S K +Q+ L Q+
Sbjct: 3677 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA-------------VQDKLDQM 3723
Query: 738 DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-------- 789
F WE ++ + ++R+ + +E +F D + + + F+R + P
Sbjct: 3724 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 3783
Query: 790 ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQ 849
+ E A+ ++E DG+ + +V L G E+I + D I+++ + LN W
Sbjct: 3784 QQQEAAET---IREEIDGLQEELDIVINL---GSELIAACGEPDKPIVKKSIDELNSAWD 3837
Query: 850 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQ 908
+ K DR +LEE ++Q L W++ A +AS+ + +K+++E+
Sbjct: 3838 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 3897
Query: 909 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALP 966
+K E +Q +++LN +L EE DK +++ L + L W + +
Sbjct: 3898 LKQFKSEAYQQQIEMERLNHQAELLLKKVT---EESDKHTVQDPLMELKLIWDSLEERII 3954
Query: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEI 1026
+Q ++E + LGQ + L++L L WL+ L Q G E E+
Sbjct: 3955 NRQHKLEGALLALGQFQHALDEL-------LAWLTHTEGLLS--EQKPVGGDPKAIEIEL 4005
Query: 1027 A--------VQAKQPDVEEILSKGQHLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQEL 1076
A V A Q VE + G L + + ++ KLE L+ W+ V
Sbjct: 4006 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV------- 4058
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
++T K ++ +L F+
Sbjct: 4059 ------------------------------LEKTEQRKQQLDGALR----QAKGFHGEIE 4084
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1196
+L WL+ ++ + + + + G E E + E + + L+ Q + +
Sbjct: 4085 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4144
Query: 1197 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 1256
+ A T I I ++ +W+ V+ L R+ +L E L + ++ + ++ L QA
Sbjct: 4145 CP-KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4203
Query: 1257 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
L +D + +I E K A ++ + + + L D +
Sbjct: 4204 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4263
Query: 1317 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 1376
+ ++ + W + +R+ ER +L++ + +QF K + WL E+E + +
Sbjct: 4264 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD------S 4317
Query: 1377 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 1436
+ + D +K + Q ++ Q + A VY + + + +DD + L L
Sbjct: 4318 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4377
Query: 1437 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 1496
+ KW + KS+ ++ LE + + +LQ L+ WL + +L+ P+ GD
Sbjct: 4378 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL 4437
Query: 1497 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 1556
V D H+AF++EL + ++ L + REL E +++
Sbjct: 4438 VMNLIDNHKAFQKELGKRT-------------------SSVQALKRSARELI--EGSRDD 4476
Query: 1557 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 1616
+ ++ Q +E++T WE + S Q +++ L + +E L L +AE
Sbjct: 4477 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4536
Query: 1617 QPVGD------LLIDSLQDHLEKVKALRGEI 1641
+ D LID ++ ++K++ R E+
Sbjct: 4537 GVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4567
Score = 213 bits (541), Expect = 2e-54
Identities = 318/1675 (18%), Positives = 668/1675 (39%), Gaps = 181/1675 (10%)
Query: 12 KKAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK-- 68
+K+ R +LL+Q++ +A+ E + L+ DK + D Q+++
Sbjct: 3184 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3243
Query: 69 IQSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN----- 122
+Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3244 LQEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3301
Query: 123 FEQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 172
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K
Sbjct: 3302 LEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNK 3361
Query: 173 SEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM 232
+ ++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3362 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3421
Query: 233 RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 292
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3422 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3481
Query: 293 ALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 351
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3482 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3541
Query: 352 IQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3542 TETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3601
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ-- 459
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3602 S----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657
Query: 460 ---GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQ 507
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 3658 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717
Query: 508 QLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR- 563
L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 3718 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 3777
Query: 564 DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFA 620
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 3778 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 3837
Query: 621 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 680
+ +I + EE M + Y + V + L +
Sbjct: 3838 SLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPI 3884
Query: 681 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDF 739
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 3885 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 3944
Query: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 3945 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEI 4003
Query: 800 YLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLS 856
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4004 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4063
Query: 857 DRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVE 914
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4064 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCA 4122
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIE 973
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4123 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLE 4179
Query: 974 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---A 1027
+ + L+D + WL+ L + ++P+ F + E ++
Sbjct: 4180 EALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4232
Query: 1028 VQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLA 1084
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4233 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------- 4285
Query: 1085 PGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL 1144
SL F+ AW++L +WL
Sbjct: 4286 -----------------------------------SLDDARKRAKQFHEAWSKLMEWLEE 4310
Query: 1145 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 1204
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4311 SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL 4370
Query: 1205 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 1264
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4371 KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP 4430
Query: 1265 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1324
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4431 VHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELST 4489
Query: 1325 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLL 1381
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4490 RWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL 4549
Query: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
D KE MK+ ++ + E+ T + + ++ D ++ + + +
Sbjct: 4550 IDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRAR 4599
Query: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQK 1499
+ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659
Query: 1500 QNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQ 1542
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 4660 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYP 4719
Query: 1543 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 4720 SGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 4766
Score = 206 bits (525), Expect = 2e-52
Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)
Query: 19 KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 78
K L Q + E S E++T K+ + Q +E I L S
Sbjct: 2625 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 2684
Query: 79 SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 124
S + + +++ Q + Q+D+A++ QD+ ++ + Q+ +
Sbjct: 2685 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 2744
Query: 125 QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 163
Q++ E L+ E L ++ + E +Q Q
Sbjct: 2745 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 2804
Query: 164 LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 222
K L + + + KT + ++ ++T + + + AL N+L + R++Q+
Sbjct: 2805 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 2864
Query: 223 EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 281
E +K + ++ + L + + V ++ ++ K QK EIE +
Sbjct: 2865 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 2924
Query: 282 VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 339
+ + +G+ L K + +E L +N+ W + + + L E H
Sbjct: 2925 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 2984
Query: 340 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 399
F ++ + W++ + L+ + +K P + V+K E ++ +D R ++
Sbjct: 2985 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3041
Query: 400 NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 451
G+ EP Q+S L+ R+ A+ ++ +T ++LE + Q+ E
Sbjct: 3042 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3096
Query: 452 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 509
LE + +++ N + ++E + + L+ I + K + + I Q L
Sbjct: 3097 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3156
Query: 510 LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 568
KD+ + L+ S WY + + ++ + L E DE ++
Sbjct: 3157 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3210
Query: 569 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 628
E+ K +L+ EGL + + + V I L K + ++ LN
Sbjct: 3211 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3263
Query: 629 QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 681
++ T +E +++ + ++ Y T L T++ + L++ + L++ +LC
Sbjct: 3264 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3323
Query: 682 -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
+E + K EE+ K +K + + +D ++ +A L+ R
Sbjct: 3324 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3383
Query: 728 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 785
L++ +++ + ++ V+ + D ++ + ++F W+TE E+ L
Sbjct: 3384 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3443
Query: 786 -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 844
++ ++ A+ + K I + + ++ L +G +I+ S+ + +++KL +
Sbjct: 3444 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3502
Query: 845 NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 903
+ +C+ S+R +LE ++++++F E WL E +I S +P + + L+
Sbjct: 3503 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3562
Query: 904 EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 963
++ E+ + L E + + + ++N+TG +L +SP E ++ K + + ++
Sbjct: 3563 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3619
Query: 964 ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1022
+ ++ ++ I Q K++ + E L ++ L P E+ + +E + +
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 3677
Query: 1023 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1076
+ ++ QP E + +G+ + T + V+ KL+ + W+ ++ L++E
Sbjct: 3678 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 3737
Query: 1077 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1136
AK +L+V LA+ + W
Sbjct: 3738 EAK------------------------------------------LLDVMELAE--KFW- 3752
Query: 1137 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1193
D +SL+ IK + + DLED I+ ++K Q+ + + + L+E + NL
Sbjct: 3753 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 3809
Query: 1194 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1250
++ + + I+ I+ + + WD + + ++R +L E ++ + Q+ + +
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 3869
Query: 1251 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1310
+ A KL S ++ ++++I E KQ + Q Q ++ N A LL+ + +
Sbjct: 3870 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 3929
Query: 1311 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1369
D V + W S+ +R+ R+ LE L QF L++ LAWLT E
Sbjct: 3930 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 3987
Query: 1370 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1429
+ ++ + D K ++ + + LQ ++ AH +++ ++ S G ++A
Sbjct: 3988 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4042
Query: 1430 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1489
LQ +L+ +N +W + +K+ + L+ + Q K H +++L WL + L P
Sbjct: 4043 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4102
Query: 1490 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1549
+GG ++Q +VH + KE S ++ + L P + Q+ L
Sbjct: 4103 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4160
Query: 1550 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1609
+WE + + + K++E L E + + L QA
Sbjct: 4161 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4202
Query: 1610 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1668
E + + +P L++D++ +++ K E+ +E + ++ L +
Sbjct: 4203 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4260
Query: 1669 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1699
+ + L + +RW+ + + +R R L +A +
Sbjct: 4261 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4292
Score = 198 bits (503), Expect = 6e-50
Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)
Query: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 77
++Q+I + + + L + + L+ +D +L++ +A M Q+ AQK++ ++ +
Sbjct: 2319 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2378
Query: 78 ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 122
+ EE K ++ + S DV QK V
Sbjct: 2379 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2438
Query: 123 FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 182
F+Q ++ + LD K S + +V++S + + K+L+ E I G
Sbjct: 2439 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2498
Query: 183 RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 242
++ K Q L ++ +K +++ +V ER+ +L++ L+ + K ++++ L W
Sbjct: 2499 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2558
Query: 243 LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 301
+ L + + ++ P+ ++ +A K+ QKE+++ ++ + +L +V
Sbjct: 2559 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2616
Query: 302 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 361
+ +V D+ L VT + L + + F + + + A LD
Sbjct: 2617 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 2676
Query: 362 EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 416
+ Q + +L+ + L ++ +VD + A +L+ D V Q+ +
Sbjct: 2677 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 2736
Query: 417 NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 474
+ +S ++ K L+ + F + I+++ + ++ + + +
Sbjct: 2737 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 2796
Query: 475 DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 520
+ T+K L++ DN + T+E + + IK+ L L + N L D
Sbjct: 2797 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 2855
Query: 521 RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 568
R+Q R++ +E + ++Y ++ LL+ ++ E+ + ++ + + K+
Sbjct: 2856 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 2915
Query: 569 -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 622
KE LQ K++++N + +GL + A +E ++ RW+ + K AQ
Sbjct: 2916 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 2972
Query: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
+L A +H R + + + +++ E+L+ +
Sbjct: 2973 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3011
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
+F+ + Q + K ++ L +++I + +A P ++VK+ + LS LD +WE
Sbjct: 3012 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3071
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 801
+ + R + + ++FH ++ N+WLT E+ L + P + +K + +
Sbjct: 3072 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3130
Query: 802 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+D I + + G+ + SS+ D ++Q KL + + E+ ++ R
Sbjct: 3131 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3190
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
+ L++ F D E + WL E D ++ + ++ + L ++ ++++L E++ L
Sbjct: 3191 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3250
Query: 919 R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 963
R Q +L L TG VL+ + ++ KL + +T Q ++++R
Sbjct: 3251 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3310
Query: 964 ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 996
L E+ E Q+ K+L + K + L + LN +
Sbjct: 3311 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3370
Query: 997 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1051
LL L P R LE + E V +T + K +++ + + Q + A
Sbjct: 3371 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3427
Query: 1052 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1090
T+ L D+ E + LQ + + D+ L T
Sbjct: 3428 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3487
Query: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1147
Q++ V+ I ++ L LE A + N+ W EL WL+
Sbjct: 3488 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3546
Query: 1148 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1207
+I + E + + + + + + + +P ++++ L + + I
Sbjct: 3547 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3604
Query: 1208 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1266
++ + +++E ++ R L+E + STQ+ ++ +Q+L +E ++ P
Sbjct: 3605 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 3661
Query: 1267 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1323
V+ I+++I+E K ++ D+ + Q + +++ R D + + ++
Sbjct: 3662 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 3721
Query: 1324 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1380
W +IH V EREA L + L ++F D + + + + L+D +
Sbjct: 3722 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 3781
Query: 1381 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1440
++ + E ++ +++ G ++ D+ NL L + G D ++++ +D +N
Sbjct: 3782 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 3834
Query: 1441 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1500
W L K + LE + + LQ + W+ + +L+ +PIG D V++Q
Sbjct: 3835 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 3894
Query: 1501 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1560
+ + FK E +Q +E +E+L + L + ++ +
Sbjct: 3895 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 3935
Query: 1561 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1620
+ E+ W+ L + Q K++ L L + Q A DEL L E + +PVG
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995
Query: 1621 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1679
+++ L K L+ ++ + V VN L NL + LE LN R
Sbjct: 3996 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4054
Query: 1680 WKLLQVAVEDRVRQLHEAHR 1699
W+ + E R +QL A R
Sbjct: 4055 WQNVLEKTEQRKQQLDGALR 4074
Score = 191 bits (486), Expect = 6e-48
Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)
Query: 33 KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 88
++L +E++ K+L A +A +A +M ++ DL + LE + K N+
Sbjct: 2793 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 2852
Query: 89 GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 148
+ AQ Q++ K+L++ F +L+E ++L + + H +
Sbjct: 2853 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 2899
Query: 149 VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 206
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 2900 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 2959
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
+ L KV +R QL++ L + + + L W+ T+ + + + ++
Sbjct: 2960 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3019
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 325
+ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++AE
Sbjct: 3020 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3079
Query: 326 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 383
L + F + ++ + +W+ + L E Q E+ + + KA +DI
Sbjct: 3080 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3139
Query: 384 RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 438
Q+ ++++R D + +V+ ++ F+ + + I+ + S E
Sbjct: 3140 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3191
Query: 439 LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 496
L Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3192 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3245
Query: 497 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 556
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K L
Sbjct: 3246 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3302
Query: 557 ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 614
+ R++ EL K E+ + + + L + A+ A + +L K +
Sbjct: 3303 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3359
Query: 615 IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3360 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3418
Query: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 728
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3478
Query: 729 ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 774
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3479 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3538
Query: 775 -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 831
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3539 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3598
Query: 832 TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 890
SI QEK + + + ++ + + R L+E + ++F +++ + LE + +
Sbjct: 3599 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657
Query: 891 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 948
P + +++KE++ + K + ++ Q + + L + G ++ + + ++ ++
Sbjct: 3658 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717
Query: 949 NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1006
+KL Q W + + E+ EA++ D+ +L +K +H L++ + ++
Sbjct: 3718 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 3768
Query: 1007 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1058
+ P + Q+ E A + Q +++ +++ G L +P VK+
Sbjct: 3769 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 3828
Query: 1059 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1118
+++L+S W ++N+ ++ I KLE
Sbjct: 3829 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 3853
Query: 1119 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1178
+ A + + DW+ + + S + DLE + + I + K + Q
Sbjct: 3854 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907
Query: 1179 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1238
++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 3908 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 3967
Query: 1239 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1298
Q+ A +E L L K AI+ ++ + L D+ Q+ V+ N
Sbjct: 3968 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4027
Query: 1299 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1358
L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4028 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4087
Query: 1359 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418
WLT+ E + + L + KE + ++ EA + Y +L + Q++
Sbjct: 4088 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4141
Query: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478
L S + + + ++N+ KW + K ++ LE + + H SLQ+ + WL
Sbjct: 4142 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4200
Query: 1479 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1535
+ L+ + V Q D H+ F E+ + I+ +T ++ F +Q +
Sbjct: 4201 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4260
Query: 1536 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1585
++ L + + R + V + L RK+A++ + W KL +W +
Sbjct: 4261 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4311
Query: 1586 DETLERLQELQEATDELDLKLRQ 1608
+++L+ E+ D++ +L Q
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQ 4334
Score = 161 bits (407), Expect = 8e-39
Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)
Query: 30 ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 88
ETEK L + + D+ A K ++ + I + S H+I ++ Q
Sbjct: 3434 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3493
Query: 89 G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 146
K+ +VL D + + ++ Q N F + +E L E + + L
Sbjct: 3494 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3553
Query: 147 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 206
++E E ++ Q L + ++E K ++ + KTG Q+++ E + E+ A
Sbjct: 3554 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3612
Query: 207 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 266
Y+++ V +R L++ + S + +++ + E L L + ++ + +
Sbjct: 3613 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3672
Query: 267 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 321
++ K ++EK + +++ + GE + G + V+DKL + W + +
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 3732
Query: 322 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 374
EE LL+ + E F DH++ + DT + + P +Q+++ +
Sbjct: 3733 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 3790
Query: 375 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 432
++ E++ ++ ++D + + L+A G+ + +V+ I ELN + +++ K K
Sbjct: 3791 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 3850
Query: 433 SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 472
++ Q+ +Q + LE ++ +I++ K E + + +
Sbjct: 3851 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 3910
Query: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
++ L + + L +++T+E + ++ L+ ++L++ R+ K
Sbjct: 3911 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 3964
Query: 533 HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 584
Q++ D+LL L E L+ + K EI+ ++ + + A
Sbjct: 3965 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4024
Query: 585 VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 635
V + L E A Q +L ++RW+ + K Q ++ L A+ H E
Sbjct: 4025 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4084
Query: 636 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 695
+ +T+ ++ P L E EQL ++CA FE +EE+ K
Sbjct: 4085 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4132
Query: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 755
++ QQ R K+A + + ++ L +WE V +R+ +
Sbjct: 4133 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4178
Query: 756 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 809
+ ++ FH ++ F WLT+AEQ L P ++ ++K + E+
Sbjct: 4179 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4235
Query: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869
R+ ++ L+ TG + S K D +++ L S+ RW++V ++L +R + L++ +
Sbjct: 4236 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4294
Query: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 928
+F ++ + WLEE++ LE + ++K +L Q K + L + + N
Sbjct: 4295 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4354
Query: 929 TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 988
TG + ++ ++ KL++ L + +W + E+Q ++E + GQ L+
Sbjct: 4355 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4413
Query: 989 LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1048
L + WL + QL +QP G D+ I D + K L K
Sbjct: 4414 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4455
Query: 1049 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
+ Q +KR +L S W V +QEL + +TV ++
Sbjct: 4456 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4498
Query: 1103 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1161
T+ E A+ + E +F+ L +WL+ +Q ++ V+ D +
Sbjct: 4499 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545
Query: 1162 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1215
+ +I + K M+ LE++R +L + T + + T+ + TII R E +
Sbjct: 4546 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4605
Query: 1216 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1256
+ Q+ L + +Q+L E L QW E EE + ++ + +
Sbjct: 4606 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4665
Query: 1257 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1310
+E VD K+T+T K+ A D Q+++ V A Y +
Sbjct: 4666 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 4721
Query: 1311 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1359
++ +N + W+ + ER L + L++ F D+ +K++
Sbjct: 4722 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 4781
Query: 1360 WLTEAET 1366
W+ ++
Sbjct: 4782 WMNHKKS 4788
Score = 159 bits (402), Expect = 3e-38
Identities = 324/1735 (18%), Positives = 696/1735 (40%), Gaps = 227/1735 (13%)
Query: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 71
K +QK+ + I + +E + E+L I LA + DK+ + + +++++
Sbjct: 1142 KPPFSKQKISSEEISTKKEQ------LSEALQTIQLFLAKH-GDKMTDEERNELEKQVKT 1194
Query: 72 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL--- 127
S+ + E K Q + + V + + ++ Q+ K + + E RL
Sbjct: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1254
Query: 128 QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 187
QE+ MI D + L ++K QE +Q + ++L+EV E +K +
Sbjct: 1255 QEAFMIGDGT-VELKKYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE--- 1304
Query: 188 KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 247
K E+ +++++ K+ +L K + K++L+K + + K TE +AA
Sbjct: 1305 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVK 1358
Query: 248 MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVE 306
++ +E + + W K+ E+ H + I + G + GK E
Sbjct: 1359 QLEESKTKIENL-------LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE 1411
Query: 307 DKLS--LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-E 360
D+++ LL ++ +E NL +YQK ++ + II A LL+ +
Sbjct: 1412 DEVNGNLLETDVDGQVGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQ 1469
Query: 361 SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 420
+ P++KE + K +K +++ ++ ++ M ++ ++ + + +
Sbjct: 1470 GQYLSPEEKEKLQKNMK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADY 1520
Query: 421 AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 480
H ++ + L+ LE DI L+ L+ +++ F++D+ ++G +
Sbjct: 1521 TEFEHWLQQSEQE--LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDL 1568
Query: 481 KELLQRGDNLQQRITDERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKAL 529
+ + G+ + + KR+ K+ Q+ L + + L S+
Sbjct: 1569 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1628
Query: 530 EISHQWYQYKRQADDLLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKK 579
++ ++ Y+ + LL L E + L EP R + K + ++ ++
Sbjct: 1629 DLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQ 1688
Query: 580 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 639
+ +++ AE L + A ++ P + + K +I ++ + ++ E+ +
Sbjct: 1689 VAVEKLKKTAEVLLD--ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQI 1742
Query: 640 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIK 698
+T + ++ L + +V +L E Q+ LN+ L +D+ + L+
Sbjct: 1743 TLTRSLSVQDGL--DEMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDI 1795
Query: 699 DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRS 758
Q S I+ ++ K +++ P LQ + L ++ + + +K+ + +
Sbjct: 1796 AGRQSS---INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 1852
Query: 759 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 818
K F + +L Q L + +P + + Y++E + + + L
Sbjct: 1853 KTKVELFENLSEKLQTFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVL 1911
Query: 819 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE 878
++ +EI +D +++ EK +L+ +++E+ + ++K+ + + L FQ +
Sbjct: 1912 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 1971
Query: 879 FVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVS 936
W++E I + L + LE K L E+ L+ ++++N +G + L+S
Sbjct: 1972 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031
Query: 937 APISPEEQDKL----------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK- 984
A +P + E T W K ++ + +I +DLG L K
Sbjct: 2032 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2091
Query: 985 ----------KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP- 1033
KL+ +E+ + ++ WL + + Q P D + + V+ +
Sbjct: 2092 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSF 2149
Query: 1034 ---------DVEEILSKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQP 1081
V+E+ K L +E P T K+ L ++ S+W+ +N+L + + K
Sbjct: 2150 EAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2209
Query: 1082 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1141
+ + LT Q + Q +V KE +S L
Sbjct: 2210 ESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGP------------------------ 2241
Query: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
LS+ ++ +QR V + +Q+ R+PQ E+L A Q + ++
Sbjct: 2242 LSIDPNMLNTQRQQV-------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDP 2288
Query: 1202 A-RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 1260
+ R I+ +++ + +WD + L +R +++ + STQ+ L KL
Sbjct: 2289 SLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS 2348
Query: 1261 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKV 1315
S DA+ +++ +++ ++++Q + + VA DL+ + +Y A+ +R++
Sbjct: 2349 SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQL 2408
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
I ++ + V ++A +H+ QQ D F AWL + N +
Sbjct: 2409 EGILKSFKDVEQKAENHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPIS 2464
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
K +LE L+K +D + A + +Y + +L +GS+ A LQ +L
Sbjct: 2465 AKLDVLE------SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQL 2517
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIG 1491
+ + W K+ + L+ S ++ + ++ L W+ + L P
Sbjct: 2518 NTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE 2577
Query: 1492 GD-----FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 1546
G+ ++QK+ D H L ++S E + +T++ ++K+ +
Sbjct: 2578 GENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2637
Query: 1547 LPPEERA-QNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEA 1598
L ++ +N+T+ K+ +EV+ E K L A Q I ++L + L LQ
Sbjct: 2638 LHSKKFCLENMTQKF-KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695
Query: 1599 TDELDLKLRQAEVIKGSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1648
L Q ++ K Q DL++++ D L +V+ + E + L + V
Sbjct: 2696 QKSLQALKHQVDLAKRLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 2747
Score = 149 bits (376), Expect = 3e-35
Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)
Query: 47 KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 104
K L+ IA D + + +E + +Q ++S ++++E++KK + +A +L + Q
Sbjct: 1657 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 1716
Query: 105 KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 154
K L D+ ++ K N + L S + LDE+ + +E+ EQ V
Sbjct: 1717 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 1776
Query: 155 -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 209
Q ++ + L + ++ +S + + + ++ ++ L ++ L ++
Sbjct: 1777 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 1836
Query: 210 ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
E AK+ E K ++E LS K++ + T+ A T++++ + E +
Sbjct: 1837 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 1893
Query: 263 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 322
+ + +K +E LK I+ G L + LV +K + L+ + +
Sbjct: 1894 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 1947
Query: 323 AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 369
+E + Q+ ++ F V + W I+Q A+ L E K Q+
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2007
Query: 370 EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 402
+ LK + + L ++ V + T AN+G
Sbjct: 2008 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2067
Query: 403 ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 446
+ L++ +I+ELN + + + + A + L+++ + +
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2127
Query: 447 QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 506
Q+ P + E + + + F ++ + N V+EL + L + D + K
Sbjct: 2128 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2186
Query: 507 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 565
+ +K L L R++K E S+ Q++ L + L + E ++ L P D
Sbjct: 2187 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2246
Query: 566 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 625
+ +++Q +E + Q E L+ G + P + + +
Sbjct: 2247 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2296
Query: 626 NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 682
A + T + +++ D ++ + V ST Y + + +S L +++ L++ +
Sbjct: 2297 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2355
Query: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 740
+ + +Q E+ + +K +QQ +I + + + +AL VK + ++L Q
Sbjct: 2356 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2407
Query: 741 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 800
E + K +KD + + + V+ + F Q + + +L + +N H
Sbjct: 2408 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2466
Query: 801 LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 850
L L+ I + +TL A GE ++ ++ ++ + LQ +L ++ W
Sbjct: 2467 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2526
Query: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 907
KQ+ +R+ +L+E +++ + W+++ +N+ I L+P + + KL
Sbjct: 2527 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2585
Query: 908 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 967
K L +E+ G+++ LN T +L I E ENK
Sbjct: 2586 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2625
Query: 968 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1027
L +K++ + EQL+ L + + + + + ++E + ++
Sbjct: 2626 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 2667
Query: 1028 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
+Q D+ + L + K Q ++ L+ L + RL Q+L + D
Sbjct: 2668 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 2722
Query: 1088 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1145
+ T V L + + + + +S+ E S L ++ + F E+ +
Sbjct: 2723 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 2778
Query: 1146 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1205
D + S + D E + KQK T++ ++ LE L+ + N NKT T
Sbjct: 2779 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 2830
Query: 1206 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1257
T +E + Q +++ + Q R +Q+ +K ++ +E +L +A
Sbjct: 2831 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 2890
Query: 1258 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1315
ES + I +++ K K+ + Q N L L++ + + T+ +
Sbjct: 2891 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950
Query: 1316 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1375
+++NA W++++K+V++R A L+E +F LE L+W+ + E A
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3005
Query: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
+K E K VK +++ + LQ ++ + +KI + E +D +L ++L
Sbjct: 3006 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3063
Query: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1495
++ +W L K+ LE S ++ H +L+ L WL + L PIG
Sbjct: 3064 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3123
Query: 1496 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1550
+++Q H+A + ++ + +S +++++ + + + ++ + + + +
Sbjct: 3124 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3183
Query: 1551 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1605
E++ + + LL++ E + +W ++ + L +L +T+ L +L+
Sbjct: 3184 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3242
Query: 1606 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1651
+ Q +++ Q V L++ L QD LE +KA +I L +V+
Sbjct: 3243 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3301
Query: 1652 NDLARQL 1658
+ A QL
Sbjct: 3302 LEQALQL 3308
Score = 129 bits (324), Expect = 3e-29
Identities = 348/1814 (19%), Positives = 706/1814 (38%), Gaps = 343/1814 (18%)
Query: 61 QMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDV-SMKFRLFQK 119
++ +E ++++ DL + EE + + S+++V + + V SM K
Sbjct: 785 KLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK 844
Query: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE--- 176
L+ ++ VK++ ETK E+E V + N+ NL +L + +SEV+
Sbjct: 845 LKTVNLVLKNTQAAEALVKLY----ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
Query: 177 MVIKTGRQIVQKKQ--------TENPKELD-----ERVTALKLHYNELGAKVTERKQQLE 223
V +QK + T ++LD E+ L + + ++ R + LE
Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
Query: 224 KCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH 283
K + R + L +W+ +E T+R E P N
Sbjct: 961 GIGKSLKYYRDTYHPLDDWIQ--QVETTQRKIQENQPEN--------------------- 997
Query: 284 LKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
+ L T L +++ LV + + + S AE++ + +Y+ T+
Sbjct: 998 -------SKTLATQLNQQKMLVSE-IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM 1049
Query: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGD 403
VD K ++ +++ Q D++ + E D+R + + + GD
Sbjct: 1050 VDSQQKSPVK---------RRRMQSSADLIIQ---EFMDLRTRYTALVTLMTQYIKFAGD 1097
Query: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE-----IQ 458
++L E + S + + KEL+++ S+I K L+ E +
Sbjct: 1098 SLKRLEEEEKSLEEEKKEHVEKA----------KELQKWVSNISKTLKDAEKAGKPPFSK 1147
Query: 459 QGVNLKEEDFNKDMNEDNEGTVKELLQR-GDNLQQRITDERKREEIKIKQQLLQTKHN-- 515
Q ++ +E K+ + T++ L + GD ++TDE +R E++ + + LQ +N
Sbjct: 1148 QKISSEEISTKKEQLSEALQTIQLFLAKHGD----KMTDE-ERNELEKQVKTLQESYNLL 1202
Query: 516 ---ALKDLRSQRRKKALEI-----SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK 567
+LK L+ + +++ + + +YK + + L E +L E
Sbjct: 1203 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAF---M 1259
Query: 568 IKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI--ESKFAQFRRL 625
I + EL+K + + +++ +G S A V+ T+ L + ++ E K ++L
Sbjct: 1260 IGDGTVELKKYQSKQEELQKDMQG-SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1318
Query: 626 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH-------VSQALLEVEQLLNAPD 678
N A+I E + + E E+ V +T + E T + ++ ++E LL+
Sbjct: 1319 NEAKIKC---EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1375
Query: 679 LCAKDFED------------------------LFKQEESLKNI------------KDSLQ 702
KD E + +++E N+ +++L
Sbjct: 1376 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1435
Query: 703 QSSGRIDIIHSKKTA-------ALQSA-----------TPVERVKLQEALSQLDFQWEKV 744
Q ++ H K + A QSA +P E+ KLQ+ + +L +E
Sbjct: 1436 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1495
Query: 745 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE---NWEHAKYKWYL 801
+ + E+ +F D F WL ++EQ L + N K K
Sbjct: 1496 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1555
Query: 802 KELQDGIGQRQTVVRTLNATGEEIIQQS---SKTDASILQEKLGSLNLRWQEVCKQLSDR 858
+D I + + R + +G +++ + SK D + + + Q +DR
Sbjct: 1556 SFSEDVISHKGDL-RYITISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDR 1612
Query: 859 KKRLEEQKNILSEFQRDLNE-----------FVLWLEEADNIAS------IPLEPGKEQQ 901
+ L + N+L +DL + + L+ + AS I ++P +
Sbjct: 1613 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP---KN 1669
Query: 902 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSA-----PISPEEQDKLEN------- 949
L+ +LE+ K L ++ +Q +++L +T VL+ A P + Q L++
Sbjct: 1670 LQRQLEETKALQGQISSQQVAVEKLKKTA-EVLLDARGSLLPAKNDIQKTLDDIVGRYED 1728
Query: 950 ----------KLKQTNLQWIKVSRALPEK---QGEIEAQIKDLGQLEKKLEDLEEQLNHL 996
KL+ T + + V L E G +E+ +K+ GQ+ L++ ++
Sbjct: 1729 LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN 1788
Query: 997 LLWLSPIRNQLEIYNQPNQEGPFDVQETE----IAVQAKQPDVEEILSKGQHLYKEKPAT 1052
++ I + N N++ ++ T+ ++QAK D+ S+ H +KE A
Sbjct: 1789 IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA- 1847
Query: 1053 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1112
K+E+L ++ + L ++L+ LT + P + VT ++Q + +
Sbjct: 1848 -----KMEELKTKVELFENLSEKLQTFLETKTQALTEVDV-PGKDVTELSQYMQESTSEF 1901
Query: 1113 SK----LEMPSSLMLEVPA--LADFNRAWTELTDWLSL----LDQVIKSQRVMVGDLE-- 1160
+ LE+ SL+ E+ + L E T+ LS ++ IK ++ V +
Sbjct: 1902 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 1961
Query: 1161 -DINEMIIKQ-KATMQDLEQRRPQLEELITA---AQNLKNKTSNQEARTIITDRIERIQN 1215
D ++++K K+ +++ ++ P ++ A ++L++ QE ++ T I+++ N
Sbjct: 1962 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2021
Query: 1216 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL---GQARAKLESWKEGPYTVDAI 1272
+ L + + + A + VL G A E W T +I
Sbjct: 2022 SGISLCN--------LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT--SI 2071
Query: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
+K +T+ +DL LL+D A+ ++ +
Sbjct: 2072 KKDMTDISHGYEDLGL--------------LLKDKIAE------------------LNTK 2099
Query: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1392
+S+ + A EE+ ++Q WL + TA Q D++ VK ++
Sbjct: 2100 LSKLQKAQEESSAMMQ-----------WLQKMNKTATKWQQTPAPT----DTEAVKTQVE 2144
Query: 1393 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1452
Q + + E++ + + L + ++L + +A ++ L ++ KW EL + +++
Sbjct: 2145 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2204
Query: 1453 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 1512
+ LE SS+ + +L WL K+ +S P+ D + Q + +E
Sbjct: 2205 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2264
Query: 1513 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 1572
T++P EQ + + P E P ++ ++++Q V +W+
Sbjct: 2265 TRKPQY------------EQLTAAGQGILSRPGEDP------SLRGIVKEQLAAVTQKWD 2306
Query: 1573 KLNLHSADWQRKIDETLER-------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
L +D ID+ + + L+ L + +LD KL + + S P D
Sbjct: 2307 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV--STHP------D 2358
Query: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQ--LSPYNLSTLEDLNTRWKLL 1683
++ LE + ++ EI K+ + L L+ L + L LE + +K +
Sbjct: 2359 AMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV 2418
Query: 1684 QVAVEDRVRQLHEA 1697
+ E+ V+ L A
Sbjct: 2419 EQKAENHVQHLQSA 2432
Score = 104 bits (260), Expect = 9e-22
Identities = 306/1742 (17%), Positives = 660/1742 (37%), Gaps = 286/1742 (16%)
Query: 97 LSQIDVAQKKLQDVSMKFRLFQKPANFEQ---RLQESKMILDEVKMHLPALETKSVEQEV 153
+ Q++ Q+K+Q+ +P N + +L + KM++ E++M
Sbjct: 980 IQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMK------------- 1018
Query: 154 VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPK----------------EL 197
QS+++ C + S + E+ T R +V +Q K +L
Sbjct: 1019 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1077
Query: 198 DERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEM-NVLTEWLAATDMELTKR 253
R TAL Y + +R ++ EK L+ +K E L +W++ L K
Sbjct: 1078 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL-KD 1136
Query: 254 SAVEGMP----SNLDSEVAWGKATQKEIEKQKVHL-----------KSITEVGEALKTVL 298
+ G P + SE K Q Q + L + E+ + +KT+
Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
Query: 299 GKKETLVEDKLSLLNSNWIAVTSRAEEWL--NLLLEYQKHME--------TFDQNVDHIT 348
L + L L + + + EE + EY++ ++ T ++ + H
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1256
Query: 349 KWIIQADTLLDESEKKKPQQKEDVLKR-LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
++I T+ E KK Q K++ L++ ++ + V +T + +
Sbjct: 1257 AFMIGDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1312
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIP----------------LKELEQFNSDIQKLLE 451
L+E +++E + ++ + + K + +K+LE+ + I+ LL+
Sbjct: 1313 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1372
Query: 452 PL---------------EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 496
L + Q G + +E D + E++E LL+ + Q T
Sbjct: 1373 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN-GNLLETDVDGQVGTTQ 1431
Query: 497 E---RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLK---- 547
E ++ +++K + + + ++H A+ + +Q + LE Q+ + K + +K
Sbjct: 1432 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490
Query: 548 ----CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 603
L + EKK+ ++E +++ D + + + L ++ E L +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEE--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM 1548
Query: 604 TQIQLSKRWRE-IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 662
T+++ K + E + S R + + + + ++ S ++ H
Sbjct: 1549 TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH 1608
Query: 663 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESL---------------------------K 695
+ + N KD D ++ E K
Sbjct: 1609 ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK 1668
Query: 696 NIKDSLQQ--------SSGRIDIIHSKKTA-----ALQSATPVERVKLQEALSQLDFQWE 742
N++ L++ SS ++ + KKTA A S P + +Q+ L + ++E
Sbjct: 1669 NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN-DIQKTLDDIVGRYE 1727
Query: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKWYL 801
++K +R + ++ + + W+ E L++ Q+P N A
Sbjct: 1728 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN-STALQDIIS 1786
Query: 802 KE--LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
K L+ I RQ+ + +N ++ ++ + + AS LQ K+ L+ R+ E + +
Sbjct: 1787 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 1846
Query: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVE 914
++EE K + F+ + +LE + PGK+ Q ++E + +
Sbjct: 1847 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 1906
Query: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
L + +LK+++ G P DK K NL S+ E + I+
Sbjct: 1907 HLEVLHSLLKEISSHGLP-----------SDKALVLEKTNNL-----SKKFKEMEDTIKE 1950
Query: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN------QEGPFDVQETEIAV 1028
+ + + +++L+ + + L W+ ++ I QP+ + D ++ +
Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV-QPSFGAEDLGKSLEDTKKLQEKW 2009
Query: 1029 QAKQPDVEEILSKGQHLYK-------EKPATQPVKRKLEDLSSEWKAVN-------RLLQ 1074
K P+++++ + G L A VK L+ E A N + L
Sbjct: 2010 SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLT 2069
Query: 1075 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 1134
++ D++ G +G + + TK + + K + SS M++
Sbjct: 2070 SIKKDMTDISHGYEDLGLLLKDKIAELN----TKLSKLQKAQEESSAMMQ---------- 2115
Query: 1135 WTELTDWLSLLDQVIKS--QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 1192
WL +++ Q D E + + + K+ +L+Q +++EL
Sbjct: 2116 ------WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2169
Query: 1193 LKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL 1252
L + + + I ++W E+ + +R+Q+L E + TQ+ + + +Q L
Sbjct: 2170 LLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL 2229
Query: 1253 GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD 1310
+ + GP ++D T+ +Q+ L+++ T L A + + +
Sbjct: 2230 VEKELMVSVL--GPLSIDPNMLN-TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE 2286
Query: 1311 DTRKVHMITENINA---SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1367
D ++ E + A W S+ ++S+R +++ Q+ L L++ +
Sbjct: 2287 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2346
Query: 1368 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1426
++ L +T + + + + +++ ++ Q + +I+ + +L ++ E
Sbjct: 2347 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--- 2403
Query: 1427 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLE---ASSDQWKRLHLSLQELLVWLQLKDDE 1483
L R+L+ + + ++ +K+ N HL+ ASS Q++++ Q WL K +E
Sbjct: 2404 ----LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEE 2456
Query: 1484 LSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQE 1543
++ PI ++ H+ F + L + + T+ L + +G EK
Sbjct: 2457 QNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEK---- 2510
Query: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL- 1602
L+ Q + T W+ N + + K+ E+LE+ + +E + L
Sbjct: 2511 --------------AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 2556
Query: 1603 ---DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
D E IK P ++ + K+K+L+ E+ V +N+ A L
Sbjct: 2557 PWIDKCQNNLEEIKFCLDPAEG------ENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2610
Query: 1660 TL 1661
++
Sbjct: 2611 SV 2612
Score = 94.7 bits (234), Expect = 9e-19
Identities = 322/1853 (17%), Positives = 708/1853 (38%), Gaps = 350/1853 (18%)
Query: 2 SARKLRNLSYKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 61
S + L+ + +K + + LL+Q++ E E ++ +Q+ L ++D+
Sbjct: 249 SLQTLKLMQIRKPLLKSSLLDQNLT---EEEINMKFVQDLLNWVDEM------------- 292
Query: 62 MPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA 121
++Q D T L ++ H + + R + +
Sbjct: 293 ------QVQLDRTEWGSDLPSVESHLENHKNVHRAIEE---------------------- 324
Query: 122 NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEM 177
FE L+E+K + E++M P T + + ++SQ LN N + L + + V
Sbjct: 325 -FESSLKEAK--ISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSR 381
Query: 178 VIKTGRQIVQKKQTENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
+ +K++ E + ER T + K ++ EL ++ ++++ ++ +++ ++
Sbjct: 382 ATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL 441
Query: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEV 290
E + R +E + + ++ +W + ++ I++ + + +
Sbjct: 442 ENH-------------PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDA 488
Query: 291 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 350
EA + K+ ++ K S S+ I + +L+ E + E Q I
Sbjct: 489 KEATDYLRNLKDA-IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANL 541
Query: 351 IIQADTLLDESEKKKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 407
+ +A T++ + KP+ + LK +KA + + ++ +D L N K
Sbjct: 542 MGKAKTII----QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
Query: 408 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----L 463
++ P +E + +A +EQ ++ L ++ V+ +
Sbjct: 598 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
Query: 464 KEEDFNKDMNEDNEGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQ 508
E D + N ++K +L Q NLQ R D E +E +++++
Sbjct: 658 NEID---RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 714
Query: 509 LLQTKHNALKDLRSQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE- 565
+ K + L+S R++ E + Y + + L C D + +++ + P RD+
Sbjct: 715 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDL 773
Query: 566 -------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 618
+ +++ +EL++ K++L + + E AA + PT
Sbjct: 774 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT-------------- 819
Query: 619 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLN 675
+R E +V+ ++M ++ + STY+ ++ V+ L E L+
Sbjct: 820 --------------LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 863
Query: 676 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQ 731
+ + E + + +++N+ +L+Q +D + H+ + ++ + +
Sbjct: 864 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 923
Query: 732 EALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI-------------------- 771
LDF W K + D+ VE+W+ H I
Sbjct: 924 YKERDLDFDWHKE---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974
Query: 772 -FNQWLTEAEQFLRKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNA 820
+ W+ + E RK Q PEN + + K + E+ Q + + Q +A
Sbjct: 975 PLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSA 1034
Query: 821 TGEEIIQQSSKTDASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRD 875
T ++ Q+ A + ++ + R + + ++ D + R +++++ +
Sbjct: 1035 TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1094
Query: 876 LNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 935
+ + LEE E E++ KE +E+ K L + + LK + G P
Sbjct: 1095 AGDSLKRLEEE--------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1146
Query: 936 SAPISPEEQDKLENKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ-------- 981
IS EE + +L + LQ I++ + E++ E+E Q+K L +
Sbjct: 1147 KQKISSEEISTKKEQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
Query: 982 ---------------LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 1021
+E+K+ ++ +E+L + L+ N+L + + G V
Sbjct: 1206 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1265
Query: 1022 QETEIAVQAKQPDVEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRA 1078
+ + Q+KQ ++++ + E K +K E LS E KA + + L E +
Sbjct: 1266 ELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1323
Query: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
K L + VT + K A+ +LE S +E L
Sbjct: 1324 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NL 1370
Query: 1139 TDWLSLLD-----------QVIKSQ---------RVMVGDLEDINEMIIKQKA------T 1172
DWLS +D QVI+ + +G+ +++N +++ T
Sbjct: 1371 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430
Query: 1173 MQDLEQR----RPQLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQE 1222
++L Q+ + Q E++I+ Q + T + ++ + + + E++Q E++
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490
Query: 1223 HLQN------RRQQLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKK 1275
H + ++ +L L++ + +A E E L Q+ +LE+ + G ++ + K
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550
Query: 1276 ITETKQLAKDLRQWQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENIN 1323
+ K ++D+ + + + ++ + L+ + S D R+V ++
Sbjct: 1551 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1610
Query: 1324 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED 1383
+RS++ + + L++ Q + LA L E TA+ E + D
Sbjct: 1611 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVD 1666
Query: 1384 SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMN 1439
K ++ +++ + LQG+I + L + ++ +L + L +D +Q+ LD++
Sbjct: 1667 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIV 1723
Query: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ- 1498
++ +L K L+ + + + L E+L W+ + L Q + + A+Q
Sbjct: 1724 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 1783
Query: 1499 --------------KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
+Q+ ++ ++ K E ST +++ + + E ++
Sbjct: 1784 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 1843
Query: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
L E + L +E++ T E + + E Q +QE+T E
Sbjct: 1844 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 1903
Query: 1605 KLRQAEVIKGSWQPVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1649
+ EV+ + + L+++ + +K K + I KE V+
Sbjct: 1904 HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 1956
>gi|42717999 dystrobrevin alpha isoform 2 [Homo sapiens]
Length = 686
Score = 212 bits (540), Expect = 3e-54
Identities = 171/590 (28%), Positives = 279/590 (47%), Gaps = 72/590 (12%)
Query: 1753 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1810
DL+ +R S YRTA KLR +QK L L+ + +AL ++ L D +++ ++ L
Sbjct: 26 DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85
Query: 1811 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1868
+TI+ +L + + ++V + + LN+LL +D G+I V + K + +LC +
Sbjct: 86 STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145
Query: 1869 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1928
DK RY+F ++ S+G R L + +++P + E SFG + E S RSCF +
Sbjct: 146 DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200
Query: 1929 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1986
+ ++ FLD + +P Q +VWLP+LHR+A E H +C+ C ++GFRYR +
Sbjct: 201 QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260
Query: 1987 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP 2046
NY +CQ CF+ G H + M EY T+ + L ++ P
Sbjct: 261 CHNYQLCQDCFWRGHAGGSHSNQHQMKEY---TSWKSPAKKLTNALSKSLSCAS--SREP 315
Query: 2047 RMGYLPVQTVLEGDNMETPVTL---INFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEM 2103
P D E P+ L ++ WP + + L S + +R + +
Sbjct: 316 LHPMFP-------DQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITR-SML 367
Query: 2104 ENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERG 2160
E+SN +D+EH LI Y L +S SQP RS I ++++ +
Sbjct: 368 ESSN------------RLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK-- 413
Query: 2161 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2220
+ +++A+LE +NR + E RL+ +HE + P P + PT L+AE +L
Sbjct: 414 QQRQLIAELENKNREILQEIQRLRLEHE-QASQPTPEKAQQNPT---------LLAELRL 463
Query: 2221 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSS 2280
LRQ K LE RM L++ ++L QL L +LL+ A G+ SSPS ++ R
Sbjct: 464 LRQRKDELEQRMSALQESRRELMVQLEGLMKLLKTQGA-----GSPRSSPSHTISR---P 515
Query: 2281 QPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2330
PM +R + ++ + PQD+ TG V + +F S RN
Sbjct: 516 IPMPIRSASACSTPT-------HTPQDSLTG---VGGDVQEAFAQSSRRN 555
>gi|42718005 dystrobrevin alpha isoform 1 [Homo sapiens]
Length = 743
Score = 206 bits (525), Expect = 2e-52
Identities = 180/629 (28%), Positives = 291/629 (46%), Gaps = 93/629 (14%)
Query: 1753 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1810
DL+ +R S YRTA KLR +QK L L+ + +AL ++ L D +++ ++ L
Sbjct: 26 DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85
Query: 1811 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1868
+TI+ +L + + ++V + + LN+LL +D G+I V + K + +LC +
Sbjct: 86 STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145
Query: 1869 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1928
DK RY+F ++ S+G R L + +++P + E SFG + E S RSCF +
Sbjct: 146 DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200
Query: 1929 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1986
+ ++ FLD + +P Q +VWLP+LHR+A E H +C+ C ++GFRYR +
Sbjct: 201 QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260
Query: 1987 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK-- 2044
NY +CQ CF+ G H + M EY + + AK L N A
Sbjct: 261 CHNYQLCQDCFWRGHAGGSHSNQHQMKEYTS-------WKSPAKKLTNALSKSLSCASSR 313
Query: 2045 ---HPRMGYLPVQTVLEGDNMET----PVTLIN------FWPVDSAP---ASSPQLSHDD 2088
HP P + + ++T PVT +N P +P SSP +
Sbjct: 314 EPLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEV 373
Query: 2089 THSRI-----------------EHYASRLAEMENSNGSYLN-------DSISPNESIDDE 2124
+++ + A RLA+ G Y+N + + +D+E
Sbjct: 374 EQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNPSCMLESSNRLDEE 433
Query: 2125 HLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERGELERILADLEEENRNLQAEYD 2181
H LI Y L +S SQP RS I ++++ + + +++A+LE +NR + E
Sbjct: 434 HRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK--QQRQLIAELENKNREILQEIQ 491
Query: 2182 RLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQ 2241
RL+ +HE + P P + PT L+AE +LLRQ K LE RM L++ ++
Sbjct: 492 RLRLEHE-QASQPTPEKAQQNPT---------LLAELRLLRQRKDELEQRMSALQESRRE 541
Query: 2242 LESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDL 2301
L QL L +LL+ A G+ SSPS ++ R PM +R + ++ +
Sbjct: 542 LMVQLEGLMKLLKTQGA-----GSPRSSPSHTISR---PIPMPIRSASACSTPT------ 587
Query: 2302 LSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2330
PQD+ TG V + +F S RN
Sbjct: 588 -HTPQDSLTG---VGGDVQEAFAQSSRRN 612
>gi|42717997 dystrobrevin alpha isoform 5 [Homo sapiens]
Length = 513
Score = 206 bits (525), Expect = 2e-52
Identities = 152/523 (29%), Positives = 253/523 (48%), Gaps = 54/523 (10%)
Query: 1753 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1810
DL+ +R S YRTA KLR +QK L L+ + +AL ++ L D +++ ++ L
Sbjct: 26 DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85
Query: 1811 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1868
+TI+ +L + + ++V + + LN+LL +D G+I V + K + +LC +
Sbjct: 86 STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145
Query: 1869 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1928
DK RY+F ++ S+G R L + +++P + E SFG + E S RSCF +
Sbjct: 146 DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200
Query: 1929 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1986
+ ++ FLD + +P Q +VWLP+LHR+A E H +C+ C ++GFRYR +
Sbjct: 201 QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260
Query: 1987 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP 2046
NY +CQ CF+ G H + M EY T+ + L ++ P
Sbjct: 261 CHNYQLCQDCFWRGHAGGSHSNQHQMKEY---TSWKSPAKKLTNALSKSLSCAS--SREP 315
Query: 2047 RMGYLPVQTVLEGDNMETPVTL---INFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEM 2103
P D E P+ L ++ WP + + L S + +R + +
Sbjct: 316 LHPMFP-------DQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITR-SML 367
Query: 2104 ENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERG 2160
E+SN +D+EH LI Y L +S SQP RS I ++++ +
Sbjct: 368 ESSN------------RLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK-- 413
Query: 2161 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2220
+ +++A+LE +NR + E RL+ +HE + P P + PT L+AE +L
Sbjct: 414 QQRQLIAELENKNREILQEIQRLRLEHE-QASQPTPEKAQQNPT---------LLAELRL 463
Query: 2221 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVN 2263
LRQ K LE RM L++ ++L QL L +LL++ + + V+
Sbjct: 464 LRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGVS 506
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,368,283
Number of Sequences: 37866
Number of extensions: 3938035
Number of successful extensions: 27013
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 1026
Number of HSP's that attempted gapping in prelim test: 15180
Number of HSP's gapped (non-prelim): 7438
length of query: 2341
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2222
effective length of database: 13,741,464
effective search space: 30533533008
effective search space used: 30533533008
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.