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Search of human proteins with 48762942
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48762942 huntingtin interacting protein-1-related [Homo
sapiens]
(1068 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 2067 0.0
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 1822 0.0
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 984 0.0
gi|223029410 talin 1 [Homo sapiens] 109 2e-23
gi|156938343 talin 2 [Homo sapiens] 108 4e-23
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 92 3e-18
gi|21735548 centrosomal protein 2 [Homo sapiens] 91 6e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 84 7e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 81 5e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 8e-15
gi|148746195 trichohyalin [Homo sapiens] 80 8e-15
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 80 8e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 1e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 1e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 79 2e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 79 2e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 79 2e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 79 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 79 2e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 79 2e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 79 2e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 79 2e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 79 2e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 79 2e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 79 2e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 79 2e-14
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 79 2e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 79 3e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 79 3e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 79 3e-14
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 2067 bits (5355), Expect = 0.0
Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)
Query: 1 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH 60
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH
Sbjct: 1 MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH 60
Query: 61 EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG 120
EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG
Sbjct: 61 EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG 120
Query: 121 HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF 180
HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF
Sbjct: 121 HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF 180
Query: 181 DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC 240
DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC
Sbjct: 181 DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC 240
Query: 241 LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK 300
LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK
Sbjct: 241 LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK 300
Query: 301 PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK 360
PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK
Sbjct: 301 PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK 360
Query: 361 REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420
REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR
Sbjct: 361 REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420
Query: 421 AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ 480
AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ
Sbjct: 421 AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ 480
Query: 481 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ
Sbjct: 481 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
Query: 541 SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG 600
SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG
Sbjct: 541 SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG 600
Query: 601 RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR 660
RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR
Sbjct: 601 RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR 660
Query: 661 AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR 720
AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR
Sbjct: 661 AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR 720
Query: 721 LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG 780
LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG
Sbjct: 721 LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG 780
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT
Sbjct: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY 900
STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY
Sbjct: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY 900
Query: 901 EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI 960
EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI
Sbjct: 901 EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI 960
Query: 961 EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE 1020
EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE
Sbjct: 961 EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE 1020
Query: 1021 EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068
EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Sbjct: 1021 EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 1822 bits (4720), Expect = 0.0
Identities = 949/949 (100%), Positives = 949/949 (100%)
Query: 120 GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 179
GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM
Sbjct: 100 GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 159
Query: 180 FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 239
FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS
Sbjct: 160 FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 219
Query: 240 CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 299
CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI
Sbjct: 220 CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 279
Query: 300 KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 359
KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL
Sbjct: 280 KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 339
Query: 360 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 419
KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL
Sbjct: 340 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 399
Query: 420 RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 479
RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ
Sbjct: 400 RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 459
Query: 480 QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 539
QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE
Sbjct: 460 QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 519
Query: 540 QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ
Sbjct: 520 QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579
Query: 600 GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 659
GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS
Sbjct: 580 GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 639
Query: 660 RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 719
RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD
Sbjct: 640 RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 699
Query: 720 RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 779
RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL
Sbjct: 700 RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 759
Query: 780 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 839
GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT
Sbjct: 760 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 819
Query: 840 TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 899
TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK
Sbjct: 820 TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 879
Query: 900 YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 959
YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ
Sbjct: 880 YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 939
Query: 960 IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 1019
IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG
Sbjct: 940 IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 999
Query: 1020 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068
EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Sbjct: 1000 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1048
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 984 bits (2545), Expect = 0.0
Identities = 531/1057 (50%), Positives = 722/1057 (68%), Gaps = 46/1057 (4%)
Query: 2 NSIKNVP---ARVLSRRP-GHSLEA-EREQFDKTQAISISKAINTQEAPVKEKHARRIIL 56
+S+K VP +VLSRR G LEA ERE F++TQ +SI+KAINTQE VKEKHAR IL
Sbjct: 6 SSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCIL 65
Query: 57 GTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIG 116
GTHHEKGA TFWS LPL S+++L WKFCHV HK+LRDGHPNVL D RYR+ + ++
Sbjct: 66 GTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMS 125
Query: 117 DLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLT 176
+WGHL + YGQL ++Y KLL TK+ +H K+P+FP L+++D L++A +DVNN FQLT
Sbjct: 126 RMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLT 185
Query: 177 VEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFK 236
VEMFDY++CEL L ++VF L+ + +VS ++GQCRLAPLIQVI DCSHLY YTVKLLFK
Sbjct: 186 VEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFK 245
Query: 237 LHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALA 296
LHSCLPADTLQGHRDRF EQF L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+
Sbjct: 246 LHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALS 305
Query: 297 EHIKPVVVIPEEA--PEDE---EPENLIEISTGPPAGEPVVVADLFDQTFGPP------- 344
EHI PVVVIP EA P+ E E ++L+++ A + + + FD FG
Sbjct: 306 EHISPVVVIPAEASSPDSEPVLEKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFN 361
Query: 345 ----NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK 400
NG KD++D IE L RE+ L+++LE +K E+QR + QLK V+ LE +L EQ+
Sbjct: 362 FNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQH 421
Query: 401 QKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHV 460
+Q+A D E LR EL +LR + + E++Q E ERKA A E RY+KLKEK+SELV
Sbjct: 422 LRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQN 481
Query: 461 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRE 520
HA+LLRKNA+ KQ+++ +Q+Q ++ R K++L +E++ + + K +E+ + LE LK+E
Sbjct: 482 HADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQE 541
Query: 521 LEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRET 580
L EL Q +L + QS++ ++ L E+D+L RE +L A + +++T
Sbjct: 542 LATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDT 601
Query: 581 EAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVS 640
+ L+ S E+ + Q D++ +L G+ A ++QDA++
Sbjct: 602 QLKLA---------------------STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640
Query: 641 KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAA 700
+L++P + C S D+L+S + LE+ +QYL D S L+ ++T +HL +
Sbjct: 641 QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700
Query: 701 DTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGI 760
D I +G T AP +PAD L + C++ G L + L+++ +L + ++ +R L I
Sbjct: 701 DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760
Query: 761 LQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVN 820
+G+EL P+ LD++QEELG +VDKEMAATSAAIE A RIE+M++++R +GVKLEVN
Sbjct: 761 KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820
Query: 821 ERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG 880
ERIL CT LM+AI++L+ S LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVG
Sbjct: 821 ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVG 880
Query: 881 WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSR 940
WGAT +V+AAD VV GK+EEL+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR
Sbjct: 881 WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASR 940
Query: 941 TVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMR 1000
VN+ A VVAST SG+ QIE+ D MDFS ++L ++K+QEM++QVRVLELE L+ ER +
Sbjct: 941 GVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQK 1000
Query: 1001 LGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
LGELRK+HY LAG + E P T VT K+
Sbjct: 1001 LGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037
>gi|223029410 talin 1 [Homo sapiens]
Length = 2541
Score = 109 bits (272), Expect = 2e-23
Identities = 156/756 (20%), Positives = 295/756 (39%), Gaps = 36/756 (4%)
Query: 284 EGPPNFLRASALAEHIKPVVVIPEEAPED-----EEPENLIEISTGPPAGEPVVVADLFD 338
E N +A+ E ++ V + EA ED E + + G + L +
Sbjct: 1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDE 1840
Query: 339 QTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ 398
G P GS D + + + K ++ + K + + L +Q+ + G L +
Sbjct: 1841 GPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEE-LGPLANQLTSDYGRLASE 1899
Query: 399 RKQKQKALVDNE---QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHS 455
K A + E ++H + +L G + + A + +
Sbjct: 1900 AKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSE 1959
Query: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE-QVKRESELKLEEKSDQL 514
++ HV A L N T +T +A + + F + RE + + +
Sbjct: 1960 KVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGI 2019
Query: 515 EK----LKRELEAKAGELARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREAD 569
K L + + A +QE L+ QS +RL D + +L + +
Sbjct: 2020 LKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVV 2079
Query: 570 LLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ-RLLDEQFAVLRGAA 628
L+ A V + L + ++ + G+ + S + + L + + A
Sbjct: 2080 LINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEA 2139
Query: 629 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 688
+ L+ + L + C+ P S ++ + + A+ + +
Sbjct: 2140 TKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQE 2199
Query: 689 -VAALTRFSHLAADTIINGGATSHLAPTDPAD---RLIDTCRECGARALELMGQLQ---- 740
V A S A ++ + P D R + REC LEL+ +
Sbjct: 2200 DVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQ 2259
Query: 741 ------DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAI 794
QQ H + V + ++Q + +K V E+ + + E+ +AAI
Sbjct: 2260 KPSPELKQQLTGHSKR--VAGSVTELIQAAEAMKGTEW-VDPEDPTVIAENELLGAAAAI 2316
Query: 795 EDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG 854
E A +++E + +A+ + L E+IL + + A LV +++ Q+E+V G+
Sbjct: 2317 EAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKV 2376
Query: 855 AATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST 914
A + +W++GLISA++ V L EAA+ V E+LI + ++AAST
Sbjct: 2377 GAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAAST 2435
Query: 915 AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-ASTKSGQEQIEDRDTMDFSGLSL 973
AQL+ A KVKA++ S + RLQ V + N+V A+ K+ + ++ +T+ +
Sbjct: 2436 AQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKE-KM 2494
Query: 974 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
+ Q + Q +L E+ LE R +L ++R+Q Y
Sbjct: 2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530
Score = 37.4 bits (85), Expect = 0.076
Identities = 73/376 (19%), Positives = 131/376 (34%), Gaps = 88/376 (23%)
Query: 667 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIING-----GATSHL------APT 715
AV+T+ LT ++ L+AAL + ++ GA S L A
Sbjct: 576 AVTTISSN----LTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASA 631
Query: 716 DPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVR 775
+P L+ G + EL+ Q+ + H Q +L+
Sbjct: 632 EPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALM---------------------- 669
Query: 776 QEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIR 835
+L V AA + +R ED Q + ++ + ++ L +CT ++
Sbjct: 670 --QLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAP-- 725
Query: 836 LLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKA----------VGWGATQ 885
+S Q+++VE+GR A + EG +SAS+A VG AT
Sbjct: 726 --TISSPVCQEQLVEAGRLVA----------KAVEGCVSASQAATEDGQLLRGVGAAATA 773
Query: 886 LVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNER 945
+ +A ++++ H V +H A A R + + T+
Sbjct: 774 VTQALNELLQH--------VKAHATGAGPA-----------------GRYDQATDTILTV 808
Query: 946 AANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
N+ +S E + + + L+ K + E + + K L A ++
Sbjct: 809 TENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATA 868
Query: 1006 KQHYVLAGASGSPGEE 1021
K GA+ P E
Sbjct: 869 KMVEAAKGAAAHPDSE 884
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 108 bits (269), Expect = 4e-23
Identities = 73/241 (30%), Positives = 130/241 (53%), Gaps = 12/241 (4%)
Query: 774 VRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKA 833
V E+ + + E+ +A+IE A +++E + +A+ + L+ E+IL + + A
Sbjct: 2297 VDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAA 2356
Query: 834 IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKV 893
LV ++++ Q+E+V G+ + A + +W++GLISA++ V + L EAA+
Sbjct: 2357 TSALVKSASAAQRELVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANAS 2415
Query: 894 VLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-AS 952
V E+LI + ++AASTAQL+ A KVKA++ S + RLQ V + N+V A+
Sbjct: 2416 VQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAA 2475
Query: 953 TKSGQEQIEDRD----TMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQH 1008
K+ + +D D T G++ I ++EM L+ E+ LE R +L ++R+Q
Sbjct: 2476 QKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEM------LKKERELEEARKKLAQIRQQQ 2529
Query: 1009 Y 1009
Y
Sbjct: 2530 Y 2530
Score = 35.8 bits (81), Expect = 0.22
Identities = 45/190 (23%), Positives = 80/190 (42%), Gaps = 25/190 (13%)
Query: 783 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 842
+ K + +A ++D V ED++ AR + V +DL+KA++ T+
Sbjct: 590 MSKGVKLLAALMDDEVGSGEDLLRAARTLAGAV------------SDLLKAVQ--PTSGE 635
Query: 843 SLQKEIVESGRGAATQQEFYAK------NSRWTEGLISASKAVGWGATQLVEAADKVVL- 895
Q + +G + + + R+ + L+S +KAV A LV A V
Sbjct: 636 PRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQV 695
Query: 896 --HTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL--SRLQECSRTVNERAANVVA 951
T +I + + A ST+QLVA +KV + S + +L E + V+ N V
Sbjct: 696 AEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVR 755
Query: 952 STKSGQEQIE 961
+ ++ E
Sbjct: 756 ACQAATTDSE 765
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 91.7 bits (226), Expect = 3e-18
Identities = 156/703 (22%), Positives = 270/703 (38%), Gaps = 151/703 (21%)
Query: 353 DLQIESLKREVEMLRSELEKI----------KLEAQRYIAQLKSQVNALEGELEEQRKQK 402
+L + L+ E L+ L K+ KL+ R +AQL+ + +AL+G QR+ +
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR---QRQAE 777
Query: 403 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
Q+A V E+ + L +LR Q + R+ E E L+++ L H +
Sbjct: 778 QEATVAREE-QERLEELRLEQ------EVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830
Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEK------------ 510
+L + A ++QL+ +Q E+ R ++ +E+ RE E +E
Sbjct: 831 QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER 890
Query: 511 -----SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
S++ +L+ E EA G L Q L+ E + +L + L K+ L+G +
Sbjct: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
Query: 566 READLLAAQSLVRETEAALSRE--QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
++A Q +A+L +E Q+ Q + E Q L E+ + + QRL E+ A
Sbjct: 951 LRQQIIATQE-----KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL---VSRAQEALDAVSTLEEGHAQYLT 680
R AE A LQ + + + L R + + L ++ Q+ D L E Q
Sbjct: 1006 WRELEAERAQ-LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQAL 1064
Query: 681 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ 740
SL ++ T +++L+ T +LE+ Q +
Sbjct: 1065 SLKESEK---------------------------TALSEKLMGTRHSLATISLEMERQKR 1097
Query: 741 DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR 800
D Q+ + S V L EL+ D+R + +E AA + A E VRR
Sbjct: 1098 DAQSRQEQDRSTVNA-------LTSELR----DLRAQ-------REEAAAAHAQE--VRR 1137
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
+++ QAR + + L +L +RLL L++E++E+ R QE
Sbjct: 1138 LQE---QARDLG-----KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQE 1189
Query: 861 FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA 920
E+ A +
Sbjct: 1190 ----------------------------------------------GREVQRQEAGELRR 1203
Query: 921 SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE 980
S + K L R E R+ ++A + S K E E + + + + + E
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 981 METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVA 1023
+ T ++ +E + LEA R L ELR+Q +L + G E+A
Sbjct: 1264 LRTGLQEVERSR-LEARR-ELQELRRQMKMLDSENTRLGRELA 1304
Score = 70.5 bits (171), Expect = 8e-12
Identities = 149/703 (21%), Positives = 294/703 (41%), Gaps = 78/703 (11%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R LQ++ ++ E + L ++ + ++ +S+ ALE +L+ R + A+ +E
Sbjct: 531 RQLQVQDMRGRYEASQDLLGTLR----KQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
Query: 412 LRHELAQLRAA------------------QLEGERSQGLREEAERKASATEARYNKLKEK 453
+ E+ +LR+A Q + E + RE+ + + ++L+E+
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646
Query: 454 HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQ 513
+ V A + R+ + +QL + + +A+ ++ + + + ++ EK++
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Query: 514 LEKLKR------ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 567
E L + ELE +L RA+EA + S S+LS+ ++L+ +K L+ V Q E
Sbjct: 707 AEALTKAEAGRVELELSMTKL-RAEEA--SLQDSLSKLSALNESLAQDKLDLNRLVAQLE 763
Query: 568 ADLLAAQSLVR--ETEAALSREQQRSSQEQGELQGRLAERESQEQGLR-----QRLLDEQ 620
+ A Q R E EA ++RE+Q +E L+ +A R+ E LR Q L++Q
Sbjct: 764 EEKSALQGRQRQAEQEATVAREEQERLEEL-RLEQEVA-RQGLEGSLRVAEQAQEALEQQ 821
Query: 621 FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT 680
LR ++ LQ+ +++L L + L +EA V LE A+
Sbjct: 822 LPTLRHERSQ----LQEQLAQLSRQL----SGREQELEQARREAQRQVEALERA-AREKE 872
Query: 681 SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR-----ECGARALEL 735
+LA A +A + T+ L L + R E LE
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
Query: 736 MGQ--LQDQQALRHMQASLVRTPL--QGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
GQ L ++ L A L + + Q L +EL + L + E A + ++ AA
Sbjct: 933 EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH- 991
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL----LVTTSTSLQKE 847
E+ ++R++ A + ++ ++ +L+ + L +LQ+E
Sbjct: 992 ---EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048
Query: 848 IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG---ATQLVEAADKVVLHTGKYEELI 904
+ G A ++ A + + +E + K +G AT +E + + E+
Sbjct: 1049 -RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
Query: 905 VCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIE-DR 963
+ + + L A + A H+ + RLQE +R + ++ + + + + Q+
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
Query: 964 DTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
D D L+++ +E Q ++ E ++ E +R GELR+
Sbjct: 1168 DARD-------GLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
Score = 70.5 bits (171), Expect = 8e-12
Identities = 181/788 (22%), Positives = 296/788 (37%), Gaps = 161/788 (20%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
K D + E + V L SEL ++ + + A +V L+ + + KQ+ L +
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155
Query: 409 NEQLRHELAQLRAAQ-------LEGERSQGLREEAERK-----------------ASATE 444
E+LR +L L A+ LE +R LRE E + A E
Sbjct: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--LRESQEGREVQRQEAGELRRSLGEGAKERE 1213
Query: 445 ARYNKLKEKHSELVHVHAE---LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
A +E S + +E L N D ++L + ++++ V + +L +++V+R
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 502 ---ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 558
E+ +L+E Q++ L E ELA Q L+ E+++ E SR +TL +
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE--SRRETLGLRQRL 1331
Query: 559 LSGAV-----------------------RQREADLLAAQSLVRETE-------AALSREQ 588
L G R RE LL + R TE L +
Sbjct: 1332 LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKL 1391
Query: 589 QRSSQEQGELQGRLAERESQEQGL---------RQRLLDEQFAVLRGAAAEAAGI----- 634
+ + E EL RL+ E + QGL ++R + Q LR A G+
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451
Query: 635 ----------LQDAVSK-----LDDPLHLRCT-----SSPDYLVSRAQEALDAVSTLEEG 674
+DA ++ L+ P L C+ SP S A LD +
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGA 1510
Query: 675 HAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 727
++L L A +AL R LA ATS A +L E
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSR------ARQLQKAVAE 1562
Query: 728 CGARALELMGQLQDQQA-LRHMQASLVRTPLQGILQLGQ-ELKPKSLDVRQEELGAVVDK 785
+ G+L QA L + S+ R+ + L Q +SL + EL A +K
Sbjct: 1563 SEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK 1622
Query: 786 --EMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILN--------SCTDLMKAIR 835
+M A +E RR++++++ + S VKLE+ R L +D +
Sbjct: 1623 ISKMKANETKLEGDKRRLKEVLDASE--SRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
Query: 836 LLVTTSTSLQKEIVESGRGAATQQEFYAK------NSRWTEGLI-----SASKAVGWGAT 884
L SLQ+++ +S A T Q + +EG + ++A+ +
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
Query: 885 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV--KANKHSPHLSRLQECSRTV 942
L DK LH K L C H+ +L AA + +A K S S L E +T+
Sbjct: 1741 SLNSTRDK-NLHLQK--ALTACEHDRQVLQERLDAARQALSEARKQS---SSLGEQVQTL 1794
Query: 943 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM--- 999
A++ + Q++ L ++ +Q E + L + L+ ER
Sbjct: 1795 RGEVADLELQRVEAEGQLQ----------QLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844
Query: 1000 -RLGELRK 1006
RLG L++
Sbjct: 1845 ERLGSLQR 1852
Score = 56.2 bits (134), Expect = 2e-07
Identities = 137/563 (24%), Positives = 220/563 (39%), Gaps = 82/563 (14%)
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
LR L +LR+AQ E R+E + SA + +++ + +L + A++
Sbjct: 1511 LREFLQELRSAQRE-------RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
+ + ++ V+ +LA Q E V+R SE + DQ+ L+R L+A EL +
Sbjct: 1564 EE---ARRSVDGRLSGVQAELALQEESVRR-SERERRATLDQVATLERSLQATESELRAS 1619
Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 591
QE +S + A + L G R+ + L A++S + E QR
Sbjct: 1620 QEKIS--------------KMKANETKLEGDKRRLKEVLDASES------RTVKLELQRR 1659
Query: 592 SQEQGELQGR---LAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 648
S E GELQ L++RE+Q Q L+ R+ Q V + AG LQ V +L+ L
Sbjct: 1660 SLE-GELQRSRLGLSDREAQAQALQDRVDSLQRQV--ADSEVKAGTLQLTVERLNGAL-- 1714
Query: 649 RCTSSPDYLVSRAQEAL-DAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGG 707
V ++ AL D V L E AQ SL TR +L +
Sbjct: 1715 -------AKVEESEGALRDKVRGLTEALAQSSASLNS--------TRDKNLHLQKALT-- 1757
Query: 708 ATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQA--SLVRTPLQGILQLG 764
A H +D R+ + A + L +Q Q LR A L R +G LQ
Sbjct: 1758 ACEH--DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815
Query: 765 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
+E+ L RQE A ++ T ++D R +++ + + A + ++ E E +
Sbjct: 1816 REV----LRQRQEGEAAALN-----TVQKLQDERRLLQERLGSLQRALAQLEAEKRE-VE 1865
Query: 825 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
S L K L T +++E + S A+ R L A +
Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTV---RLSAEKGRLDRTLTGAELELAEAQR 1922
Query: 885 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVK----ANKHSPHLSRLQECSR 940
Q+ + +VV+ + E+ A QL +V+ A + +E +
Sbjct: 1923 QIQQLEAQVVVLEQSHSP---AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH 1979
Query: 941 TVNERAANVVASTKSGQEQIEDR 963
R ST GQ Q E R
Sbjct: 1980 RQRVRGLEEQVSTLKGQLQQELR 2002
Score = 50.8 bits (120), Expect = 7e-06
Identities = 87/412 (21%), Positives = 162/412 (39%), Gaps = 52/412 (12%)
Query: 384 LKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQ---LRAAQLEGERSQGLREEAERKA 440
L+ +++ +E L + R ++ + + + L Q L +LE + +GL ++
Sbjct: 86 LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQS---- 141
Query: 441 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK 500
V + +L + A ++L Q+ Q+ A++ ++L ++ Q K
Sbjct: 142 -----------------VELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
Query: 501 R---ESELKLEEKSDQLEKLK-------RELEAKAGELARAQEALSHTEQSKSELSSRLD 550
+ E E +L E+S +LE+ + ++LE+ L Q+ + Q + L +LD
Sbjct: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLD 244
Query: 551 TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
+ ALS +R+ D + + EAA RE++ + RL Q
Sbjct: 245 QAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVV 304
Query: 611 GLRQRLLDE-------QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-- 661
G R RL+ E L G A + +Q+A L L L + + L +A
Sbjct: 305 GFR-RLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL 363
Query: 662 -----QEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTD 716
++ D V ++ Q + S D + L A +T LA + D
Sbjct: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG-LAVKRLEKQNLEKDQVNKD 422
Query: 717 PADRL--IDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQE 766
++L +++ R ALE QQ LR + +++ G+ G E
Sbjct: 423 LTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474
Score = 50.1 bits (118), Expect = 1e-05
Identities = 70/286 (24%), Positives = 137/286 (47%), Gaps = 27/286 (9%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ--LRH 414
E +R+ ++++ KI L+ ++ ++L+ Q+ GELE+QR + + D E +R
Sbjct: 164 EGQQRQAQLVQRLQGKI-LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL 222
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAEL-LRKNADTAK 473
E Q R+A L + + LRE+ ++ SA +A +++ ++ EL R+ A +
Sbjct: 223 EEEQQRSASL-AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281
Query: 474 QLTVTQQSQEEVARV----KEQLAFQ--VEQVKRESELKLEEKSDQLEKLKRELEAKAGE 527
+ + E +R+ ++ + F+ V +VK +E L + +L + R ++
Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341
Query: 528 L--------ARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREADLLAAQSLVR 578
L +RA+ AL +++L +L D + EKD A +Q ++DL A R
Sbjct: 342 LSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDL---AQQQMQSDLDKADLSAR 398
Query: 579 ETEAALS-REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
TE L+ + ++ + E+ ++ L E+ + LR L EQ A+
Sbjct: 399 VTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR---LQEQAAL 441
Score = 47.8 bits (112), Expect = 6e-05
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 86/277 (31%)
Query: 376 EAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREE 435
EA++ + L QV L GE+ + Q+ +A +QLR L Q R+E
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ--------------RQE 1824
Query: 436 AERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQ 495
E A L Q+ Q+E ++E+L
Sbjct: 1825 GE----------------------------------AAALNTVQKLQDERRLLQERLG-- 1848
Query: 496 VEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHT--EQSKSELSSRLDT-- 551
L+ QLE KRE+E A L + + AL T + + +L S DT
Sbjct: 1849 ----------SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
Query: 552 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---------QEQGELQGRL 602
LSAEK L + E +L AQ +++ EA + +Q S Q+Q ELQ +
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
Query: 603 ---------AER--ESQEQGLRQRL--LDEQFAVLRG 626
ER E++E+ RQR+ L+EQ + L+G
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
Score = 36.6 bits (83), Expect = 0.13
Identities = 45/182 (24%), Positives = 77/182 (42%), Gaps = 28/182 (15%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
Q+E+ KREVE LEK ++ +R + +++ + L + R +K +D
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVERE--KLRSHEDTVRLSAEKGRLDR----- 1908
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
L A+LE EA+R+ EA+ L++ HS A+L D +Q
Sbjct: 1909 ---TLTGAELE-------LAEAQRQIQQLEAQVVVLEQSHSP-----AQL---EVDAQQQ 1950
Query: 475 LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEA 534
QQ E + + Q +E +R ++ +Q+ LK +L+ EL R+
Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ---ELRRSSAP 2007
Query: 535 LS 536
S
Sbjct: 2008 FS 2009
Score = 33.1 bits (74), Expect = 1.4
Identities = 71/304 (23%), Positives = 134/304 (44%), Gaps = 37/304 (12%)
Query: 731 RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQ----------EELG 780
+++EL QLQ++QA + + Q QL Q L+ K L ++ E G
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
Query: 781 AVVDKEMAAT--SAAIEDAVRRIEDMMNQARHAS----SGVKLEVNERILNSCTDLMKAI 834
+ + + T S +E A+ R+E+ Q R AS + + E ++ ++ L + I
Sbjct: 200 ELEQQRLRDTEHSQDLESALIRLEE--EQQRSASLAQVNAMLREQLDQAGSANQALSEDI 257
Query: 835 RLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEG----LISASKAVGWG--ATQLVE 888
R + T +KE+ R AA ++E + N+ ++ L+ + VG+ +++
Sbjct: 258 RKVTNDWTRCRKEL--EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
Query: 889 AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 948
++ +L G EL S + + L ++ ++ L + + E+ +
Sbjct: 316 FTERDLLQLG--GELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD 373
Query: 949 VVASTKS-GQEQIE-DRDTMDFS------GLSLIKLKKQEMETQVRVLELEKTLEA-ERM 999
V K Q+Q++ D D D S GL++ +L+KQ +E +L + LEA E +
Sbjct: 374 KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
Query: 1000 RLGE 1003
RL E
Sbjct: 434 RLQE 437
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 90.9 bits (224), Expect = 6e-18
Identities = 167/715 (23%), Positives = 304/715 (42%), Gaps = 103/715 (14%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
K + +++++ + E+E ++++ E+ + +A+ + Q++ + L E Q QK L D
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 409 NEQLRHELAQ-LRAAQLEGERSQGLRE----EAERKASATEARYNK----LKEKHSELVH 459
Q L Q ++ +L+ + + G+ + EA+R+ ++ L+E+ S L+
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 460 VHAELLRKNADTAKQLTVTQQSQEEVAR-VKEQLAFQVEQVKRESELKLEEKS---DQLE 515
+L ++ D QL SQ V + V+E+L E + + EL+ E+ S +E
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 516 KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 575
K +R L + + R QE LS Q E LSA+ + L V+++EAD LA ++
Sbjct: 1064 KEQRLLVLQEADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 576 -LVRETEAALSREQQRSSQ------EQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
L+ E EA+ EQQ + + +LQ RL ESQ + L ++Q G
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL---AAEQQ----PGNQ 1175
Query: 629 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 688
A+A L S L L C S P+ +S ++ +V LE SL L
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPE--LSGGGDSAPSVWGLEPDQ-NGARSLFKRGPL 1232
Query: 689 VAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHM 748
+ A L+A+ + + H + D R+ + +L +L D +A
Sbjct: 1233 LTA------LSAEAVASALHKLH-QDLWKTQQTRDVLRD---QVQKLEERLTDTEA---- 1278
Query: 749 QASLVRTPLQGI-LQLGQELKPKS-LDVRQEELGAVVDKEMAATSAAIEDAVRRI----- 801
+ S V T LQ + QL Q + KS + +Q L + + E+ T A+++ +RR
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL-MELHETMASLQSRLRRAELQRM 1337
Query: 802 -------------EDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
E++ Q H + V V R S +++ ++ L+ E
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAV---VEARAQASAAGILEEDLRTARSALKLKNEE 1394
Query: 849 VES--GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVC 906
VES R A Q++ K ++ + + + L E ++V G+ +EL
Sbjct: 1395 VESERERAQALQEQGELKVAQGK----ALQENLALLTQTLAEREEEVETLRGQIQEL-EK 1449
Query: 907 SHEIAASTAQLVAASKVKANK----HSPHLSRLQEC-------SRTVNERAANVVASTKS 955
E+ + +L++ K N+ + L++C V ER + +
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 956 GQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK---TLEAERMRLGELRKQ 1007
+E +DR+T Q + ++LELEK +E++R ++ +L+KQ
Sbjct: 1510 IRELEKDRET-------------QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551
Score = 79.3 bits (194), Expect = 2e-14
Identities = 116/537 (21%), Positives = 226/537 (42%), Gaps = 88/537 (16%)
Query: 351 DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN- 409
+RD +++S + ++E L+ + E + + +R +L Q ++ LE+QR ++ K L ++
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ-VLEDQRTRQTKILEEDL 1685
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKL---------KEKHSELVHV 460
EQ++ L + R +L +R Q ++E AE ++A+ L KEK E
Sbjct: 1686 EQIKLSLRE-RGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE 1743
Query: 461 HAELLRKNADTAKQ-------------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
H L++ D +Q L ++Q+ QE V L Q+++ + + ELK
Sbjct: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV-----LQQQLQEAREQGELKE 1798
Query: 508 EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 567
+ QL++ +R L + EL Q+ + + + + D L + +++R
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 568 ADLLAAQSLVRETEAALS---REQQRSSQEQGELQGRLAERESQEQGLRQRLLDE----- 619
+L + R E L+ R Q + G+L+ E+E L+Q+ ++
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 620 -QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-----QEALDAVSTLEE 673
+ L+ + +A +L++ +L+ +S +RA QEAL +
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978
Query: 674 GHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
G Q+L A+ S + A T + D +H + A R+ +
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLD-----ACQAHSRQLEEALRIQE---------- 2023
Query: 734 ELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAA 793
G++QDQ LR+ + V+ Q + Q +EL+ Q+E +++K +A
Sbjct: 2024 ---GEIQDQD-LRYQED--VQQLQQALAQRDEELR------HQQEREQLLEKSLA----- 2066
Query: 794 IEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVE 850
+R+++ M Q + ER L +++R L T ++EI+E
Sbjct: 2067 -----QRVQENMIQEKQNLG------QEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Score = 72.0 bits (175), Expect = 3e-12
Identities = 156/736 (21%), Positives = 307/736 (41%), Gaps = 74/736 (10%)
Query: 312 DEEPENLIEISTGPPAGEPVVVADLFD-QTFGPPNGSVKDDRDLQIESLKREVEMLRSEL 370
+ + ++L E G + + ++ + LF+ Q K ++QI+++ + E+++ E+
Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808
Query: 371 EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH--ELAQLRAAQLEGER 428
+KLE +Q + + +A +L Q +Q+ K ++ ++ H E+ QLR + E ER
Sbjct: 809 RCLKLELDTERSQAEQERDAAARQL-AQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKER 866
Query: 429 SQGLREEAERKASATEARYN---KLKEKHSELVHVHAE-----------LLRKNADTAKQ 474
S +E A+ S + +LKE+ +E+ + A+ L + +T K+
Sbjct: 867 SWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926
Query: 475 ----LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS----DQLEKLKRELEAKA- 525
L Q+Q+E+A +QL ++ Q + +LK +E + QL++ +REL+ A
Sbjct: 927 RVSLLETLLQTQKELADASQQLE-RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 526 ---GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
+LA QE S Q K +L +++ L ++ A + R E ++ Q +RET+
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV---QEKLRETQ- 1041
Query: 583 ALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVS 640
+R Q+ +E+ L L E+E + L++ + ++ + LR EA G ++ +
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 641 KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAA 700
+++ D+L AQ LEE A ++T L A+L AA
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQ-------LLEELEASHITE----QQLRASLWAQEAKAA 1150
Query: 701 DTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGI 760
+ +T A++ + A+ L L QQAL + S R L G
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL--QQALGSVCES--RPELSG- 1205
Query: 761 LQLGQELKPKSLDVRQEELGA-VVDKE----MAATSAAIEDAVRRIEDMM---NQARHAS 812
G + P + ++ GA + K A ++ A+ A+ ++ + Q R
Sbjct: 1206 ---GGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 813 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
++ ER+ ++ + + L L + E + Q ++ E +
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 873 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
S + Q +EA + EL+ + E + + + A+ V+A +
Sbjct: 1323 ASLQSRLRRAELQRMEAQGE--------RELLQAAKENLTAQVEHLQAAVVEARAQASAA 1374
Query: 933 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVL-ELE 991
L+E RT +S +E+ + ++ K ++ + + L E E
Sbjct: 1375 GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 992 KTLEAERMRLGELRKQ 1007
+ +E R ++ EL KQ
Sbjct: 1435 EEVETLRGQIQELEKQ 1450
Score = 70.1 bits (170), Expect = 1e-11
Identities = 75/333 (22%), Positives = 150/333 (45%), Gaps = 39/333 (11%)
Query: 350 DDRDLQIESLKREVEMLRSEL---EKIKLEAQRYIAQLKSQ---VNALEGELEEQRKQKQ 403
+ +D IES + +V+ L+ +L E + LE + +++ Q + LEG+ E QR
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
Query: 404 KALVDNEQLRHELAQLRAAQLEGERSQG--LREEAERKASATEARYNKLKEKHSELVHVH 461
+D E+ EL Q +++Q+ S L E + + +++ +++E + H+
Sbjct: 1592 HLTLDLEERSQEL-QAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 462 AELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK-----RESELK-----LEEKS 511
+L R++ + Q Q +++ R + L +EQ+K R EL ++E++
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 512 DQ-----------LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS 560
++ LE +K L K E+ QE + ++ K +L +L L + S
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 561 GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ------ 614
+ QRE +++ Q ++E ++Q + E Q LA+R+ + + L+Q
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 615 ---RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
+ E+ L+GA +A L++ +L D
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQD 1863
Score = 67.4 bits (163), Expect = 7e-11
Identities = 78/353 (22%), Positives = 152/353 (43%), Gaps = 46/353 (13%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQV---NALEGELEEQRKQKQKALVDNEQLR 413
E+L + L +L +++ E Q +++++ NAL+ +L E K+++ N L
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 414 HEL--AQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
+L A+ A+L+ + E+ E + +E+R+ + + ++L +H E R+
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ-EAATTQLEQLHQEAKRQEEVL 724
Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
A+ + Q +E + R K L +++ V+R+ + + ++QL+ L E L A
Sbjct: 725 ARAV----QEKEALVREKAALEVRLQAVERDRQ----DLAEQLQGLSSAKELLESSLFEA 776
Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-------------QREADLLAAQSLVR 578
Q+ S E +K +L ++ T++ K+ + G VR ++E D A Q
Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836
Query: 579 ETEAALSREQQRSSQE-----------------QGELQGRLAERESQEQGLRQRLLDEQ- 620
E E + EQQ+++ E Q EL L E ++ L RL ++Q
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 621 -FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLE 672
++ E + A+ ++ S + L+ +E DA LE
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
Score = 60.5 bits (145), Expect = 8e-09
Identities = 137/711 (19%), Positives = 301/711 (42%), Gaps = 78/711 (10%)
Query: 344 PNGSVKDD--RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQ 401
PNGS + D Q+ L + + ELEK E + + QLKSQ + + EL+++ +
Sbjct: 232 PNGSGRMDGREPAQLLLLLAKTQ----ELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287
Query: 402 KQKALVDNEQLRHELAQLRAAQ------LEGERSQGLREEAERKASATEARYNKLKEKHS 455
L +++ + ++ A LE ++ + EA +A E + + L++
Sbjct: 288 LSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIK 346
Query: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 515
++ V E D Q + + S E + + Q +Q +++ L L
Sbjct: 347 DITQVMVE----EGDNIAQGSGHENSLELDSSIFSQFDYQ------DADKALTLVRSVLT 396
Query: 516 KLKRELEAKAGELARAQEALSHTEQSKSE-------LSSRLDTLSAEKDALSGAV--RQR 566
+ ++ ++ +LA QEA++ +Q + L RL L+ E+D L+G Q
Sbjct: 397 RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Query: 567 EADLLAAQ-SLVRETEAALSREQQRSSQE---------QGELQGRLAERESQEQ------ 610
E D L+ + L+++ L ++ + QE + +LQG A+ + +EQ
Sbjct: 457 EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
Query: 611 GLRQR-LLDEQFAVLRGAAAEAAG---ILQDAV--SKLDDPLHLRCTSSPDYLVSRAQEA 664
+R+R L E L +E+ L++A+ S L+ L + + ++RA+++
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576
Query: 665 LDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
+ +S+ E + L A+ ++AL LA D + G L + ++ + +
Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLSALN--EALALDKV---GLNQQLLQLEEENQSVCS 631
Query: 725 CRECGARALELMGQLQDQQALRHMQA-----SLVRTPLQGILQLGQELKPKSLDVRQEEL 779
E +A + Q+ +A + +A + + LQ + G EL+ D+++E+
Sbjct: 632 RMEAAEQARNAL-QVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK- 689
Query: 780 GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 839
+ K+++ + E A ++E + +A+ + V E+ + A+ + +
Sbjct: 690 -EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK--EALVREKAALEVRLQ 746
Query: 840 TSTSLQKEIVESGRGAATQQEFYAKN---SRWTEGLISASKAVGWGATQLVEAADKVVLH 896
++++ E +G ++ +E + ++ +I +K Q V A +V+
Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Query: 897 TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSG 956
+ +L + + A + AA ++ + + Q+ + +E+ N +
Sbjct: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ--KAAHEKEVNQLREKWEK 864
Query: 957 QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
+ ++ +L L++++ME ++R+ E + +EA + + E R Q
Sbjct: 865 ERSWHQQEL----AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911
Score = 57.8 bits (138), Expect = 5e-08
Identities = 87/371 (23%), Positives = 143/371 (38%), Gaps = 110/371 (29%)
Query: 348 VKDDRDLQIESLKREV---EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 404
+KD + Q++ L R+V +L S+ E+ + Q+ + + + Q E L+ Q + Q+
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810
Query: 405 ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT----EARYNKLKEKHSELV-- 458
AL +Q +L A Q E +++QG E + KA A E + LKE+H EL
Sbjct: 1811 ALAQRDQ------ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 459 ----------------------HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQV 496
V +L ++ + K L QQ E A+ E +
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 497 EQVKRESELKLEEKSDQLEKLKRE--------------LEAKAGELARAQEALSHTEQ-- 540
+ +++ L+E+ +LE L+ E EA L +A AL EQ
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984
Query: 541 -SKSELSSRLD----TLSAEKDA--------------------------------LSGAV 563
++ELS L+ TL A DA L A+
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 564 RQREADL--------LAAQSLVRETEAALSREQQRSSQEQ------------GELQGRLA 603
QR+ +L L +SL + + + +E+Q QE+ ELQ LA
Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104
Query: 604 ERESQEQGLRQ 614
++E + LR+
Sbjct: 2105 QKEQEILELRE 2115
Score = 55.5 bits (132), Expect = 3e-07
Identities = 77/338 (22%), Positives = 130/338 (38%), Gaps = 54/338 (15%)
Query: 342 GPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ-----LKSQVNALEGELE 396
G N + +L + + R+EL++++ + +R + Q L +QV L+ +
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 397 EQRKQKQKALVDNEQLRHELAQLRA----AQLEGERSQGLREEAERKASATEARYNKLK- 451
E R Q A + E LR + L+ + E ER+Q L+E+ E K + +A L
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL 1425
Query: 452 ----------------------EKHSELVHVHAELLRKNADTAKQLTVTQQSQ----EEV 485
EK E+ ELL + Q QQ Q E+
Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485
Query: 486 ARVKEQLAFQVEQ------VKRESELKLEEKSD-----------QLEKLKRELEAKAGEL 528
V E L V++ V+RE +LE+ + +LEK + +E++ G++
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 529 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
++ L E EL + ++ + QRE +A L + E Q
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 589 QRSSQ-EQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
+SSQ E + RE QE+ + EQ L+
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Score = 41.6 bits (96), Expect = 0.004
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 18/199 (9%)
Query: 351 DRDLQIESLKREVEMLRSELEKIKLEA--QRYIAQLKS---------QVNALEGELEEQR 399
+RD + + L+ E+E+ R LEK +L + A+L S +V+ +E E
Sbjct: 2203 ERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262
Query: 400 KQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVH 459
+KQ + + R E Q A+LE +RS+ R + +++ + + K K +
Sbjct: 2263 MEKQ-----SWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317
Query: 460 VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKR 519
A L + TA T ++ + K Q E V +++L LE K Q + + R
Sbjct: 2318 AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ-DYITR 2376
Query: 520 ELEAKAGELARAQEALSHT 538
+ + ELA +LSH+
Sbjct: 2377 SAQT-SRELAGLHHSLSHS 2394
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 84.0 bits (206), Expect = 7e-16
Identities = 163/797 (20%), Positives = 320/797 (40%), Gaps = 102/797 (12%)
Query: 309 APEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRS 368
A E+E+ +NL +I + V+++DL ++R + E ++E+E +
Sbjct: 1016 AEEEEKAKNLAKIRNK----QEVMISDL-------------EERLKKEEKTRQELEKAKR 1058
Query: 369 ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV--DNEQLRHELAQLRAAQLEG 426
+L+ + Q IA+L++Q++ L+ +L ++ ++ Q AL D+E L A +L+
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 427 ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVA 486
+ ++ + KAS +A K ++ EL + EL TA Q + + ++EVA
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 487 RVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------------------- 519
+K+ L Q++ +++ LEE S+QLE+ KR
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237
Query: 520 -----------ELEAKAGEL-ARAQE---ALSHTEQSKSELSSRLDTLSAEKDALSGAVR 564
E E K +L A+ QE +S ++ + EL+ + L E D +S +
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 565 QRE-------ADLLAAQSLVRETEAALSREQQRS------SQEQGELQGRLAERESQEQG 611
+ E D + +S +++T+ L E ++ ++ E + L E++ +E+
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 612 LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPDYLVSRAQEALDAVS 669
R+ L++Q L+ A+ + D + ++ + + + L R +E A
Sbjct: 1358 ARKN-LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 670 TLE------EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLID 723
LE + LT D VA+ D ++ + + DR
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 724 TCRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQEL--KPKSLDVRQEE 778
RE +AL L L++ + Q +R ++ ++ ++ L+ +
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 779 LGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLV 838
L V+ EM +ED ++ ED + +K + + + RLL+
Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 839 TTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTG 898
L+ E+ + + A K + L + +A ++++ K+
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 899 KYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQ-ECSRTVNERAANVVASTKSGQ 957
Y+ + E AS ++ A SK K L L+ E + E A++ A + Q
Sbjct: 1656 DYQREL---EEARASRDEIFAQSKESEKK----LKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 958 E--QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGAS 1015
E ++ D T SG S + +K+ +E R+ +LE+ LE E+ + L +
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLE--ARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766
Query: 1016 GSPGEEVAIRPSTAPRS 1032
+ E+A S A +S
Sbjct: 1767 DTLNAELAAERSAAQKS 1783
Score = 76.3 bits (186), Expect = 1e-13
Identities = 118/515 (22%), Positives = 213/515 (41%), Gaps = 72/515 (13%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHE 415
++ + E E R LEK L Q +A K +V+ G +E + K+K L D E L
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407
Query: 416 LAQLRAAQLEGERSQG-LREEAE----------RKASATEARYNK----LKEKHSELVHV 460
L + A + E+++ L++E + + AS E + K L E+ S
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467
Query: 461 HAELLRKNADTAKQLTVT---QQSQEEVARVKEQLAFQVEQVKRESELKLEEKSD----- 512
E R A+ ++ T ++ EE KE+ Q +Q++ + E + K D
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 513 -QLEKLKRELEAKAGE----LARAQEALSHTEQSKSELSSRLDTLSA--EKDALSGAVRQ 565
+LEK KR LE + E L ++ L TE +K L + + A E+D + +
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 566 READLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQEQGLRQRLLDEQFA 622
E L + VRE EA L E+++ + + +++ L + E+Q + + DE
Sbjct: 1588 EEKKRLLIKQ-VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN-KARDEVIK 1645
Query: 623 VLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSL 682
LR A+ ++D +L++ +S D + ++++E+ + +LE Q L
Sbjct: 1646 QLRKLQAQ----MKDYQRELEE-----ARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696
Query: 683 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
A + + AD I N + L+D R AR +L +L+++
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGK--------SALLDEKRRLEARIAQLEEELEEE 1748
Query: 743 QALRHMQASLVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVV 783
Q+ + R + L EL + K L + +EL V
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQ-ARHASSGVKL 817
+ AT +A+E + ++E+ + Q A+ ++ KL
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/345 (24%), Positives = 153/345 (44%), Gaps = 34/345 (9%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+DR + S E E L KI+ + + I+ L+ ++ E +E K K+K +
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
L+ ++A+L+ AQ++ + Q ++E E + + L E L KN
Sbjct: 1065 TDLQDQIAELQ-AQIDELKLQLAKKEEELQGA---------------LARGDDETLHKN- 1107
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGEL 528
L V ++ Q ++A ++E F+ E+ R ++E + + S++LE LK ELE
Sbjct: 1108 ---NALKVVRELQAQIAELQED--FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 529 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
A QE + EQ +EL L+ + +A +RQR A A + L + E A +
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA--TALEELSEQLEQAKRFKA 1220
Query: 589 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 648
+QG E +++E ++L + A + +Q+ +K+ + L
Sbjct: 1221 NLEKNKQG------LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 649 RCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSLADASALVAAL 692
R + S+ Q LD VST LEE + + DA++L + L
Sbjct: 1275 RVELAEK--ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Score = 62.0 bits (149), Expect = 3e-09
Identities = 59/283 (20%), Positives = 132/283 (46%), Gaps = 15/283 (5%)
Query: 355 QIESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
Q++ +RE+E R+ ++I E+++ + L++++ L+ EL + ++ A + ++
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 412 LRHEL---AQLRAAQLEGERS-----QGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
L E+ A ++A L+ +R L EE E + S E ++ ++ ++ ++AE
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
L + + K QQ + + +K +L VK + + + ++ +L+ +LE
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 524 KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
+A E A A + + TE+ E+ +++ D + + A + + L R+ E A
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM---KQLKRQLEEA 1889
Query: 584 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
E R++ + +LQ L + +GL + + + + RG
Sbjct: 1890 -EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Score = 61.2 bits (147), Expect = 5e-09
Identities = 145/707 (20%), Positives = 287/707 (40%), Gaps = 95/707 (13%)
Query: 354 LQIES-LKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGE---LEEQRKQKQKALVD- 408
LQ E+ L E E +R+ L K E + + L+S+V E L+ ++K+ Q + D
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 409 NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK-LKEKH--SELVHVHAELL 465
EQL E + QLE ++ ++ E + E + +K +KEK + + + L
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 466 RKNADTAKQLTVTQQSQ-------EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLK 518
+ + AK L + Q EE + +E+ ++E+ KR+ + + + DQ+ +L+
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 519 RELEAKAGELARAQE------------------ALSHTEQSKSELSSRLDTLSAEKDALS 560
+++ +LA+ +E AL + +++++ + +EK + +
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135
Query: 561 GAVRQR---EADLLAAQSLVRETEAALSREQQ---RSSQEQGELQGRLAE----RESQEQ 610
A +Q+ +L A ++ + +T + +Q+ + QE EL+ L E E+Q Q
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Query: 611 GLRQR---LLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDA 667
+RQR L+E L A A + ++ D L C + L
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC----------EVKVLQQ 1245
Query: 668 VSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 727
V E + L A L A ++ L + + A+ D L++ +
Sbjct: 1246 VKAESEHKRKKLD--AQVQELHAKVSEGDRLRVE--LAEKASKLQNELDNVSTLLEEAEK 1301
Query: 728 CGAR----ALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV- 782
G + A L QLQD Q L + I QL +E SL +QEE
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE--KNSLQEQQEEEEEAR 1359
Query: 783 --VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVK--LEVNERILNSCTDLMKAIRLLV 838
++K++ A + + D ++++D + K L+ E + + A L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419
Query: 839 TTSTSLQKEI------VESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADK 892
T LQ+E+ ++ R A+ E K + + L++ K++ + + E D+
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLE---KKQKKFDQLLAEEKSI---SARYAEERDR 1473
Query: 893 VVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVAS 952
+ E + +A + + + A + ++ + +++ + ++ NV
Sbjct: 1474 AEAEAREKETKAL---SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 953 TKSG---QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEA 996
KS ++Q+E+ T L +L+ + T+ L LE ++A
Sbjct: 1531 EKSKRALEQQVEEMRT------QLEELEDELQATEDAKLRLEVNMQA 1571
Score = 59.3 bits (142), Expect = 2e-08
Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 40/307 (13%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN---- 409
LQ+ + E++ EL K+K + + +EGELEE ++ Q+ L +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTK-----------VEGELEEMERKHQQLLEEKNILA 893
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
EQL+ E A+ R ++E E E+R + +E++ L + ++
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVK----RESELKLEEKSDQLEKLKRELEAKA 525
D +QL +EE AR K QL + K E L LE+++ + K K+ +E +
Sbjct: 954 DLEEQL-----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 526 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
E LA +E + + + S+L RL + L A R+ + + Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGI 634
+ E +A + + + ++++ ELQG LA + + L V+R A+ A +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRELQAQIAEL 1123
Query: 635 LQDAVSK 641
+D S+
Sbjct: 1124 QEDFESE 1130
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 81.3 bits (199), Expect = 5e-15
Identities = 147/705 (20%), Positives = 278/705 (39%), Gaps = 80/705 (11%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALVDNEQ 411
I L+ + L E+++ +Q + A+L +QV +L EL ++Q Q+ +Q
Sbjct: 468 ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527
Query: 412 LRHELAQL-RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNAD 470
+ + AQL + Q + + SQGLR + E+ +S+ LK+K +L V + D
Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS-------LKQKEQQLKEVAEKQEATRQD 580
Query: 471 TAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 530
A+QL + +E R ++ Q+E +++E KLE QL+ ++
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS------- 633
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 590
AQ +++ ++ K+ELS +++ L A V + AQ+ V E E L EQQ+
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQA-------CVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 591 SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 650
+++++ R+A+ + Q Q Q L E V +G+ E DA+ + RC
Sbjct: 687 ATEKE-----RVAQEKDQLQEQLQ-ALKESLKVTKGSLEEEKRRAADALEE-----QQRC 735
Query: 651 TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA----LVAALTRF--SHLAADTII 704
S E +L E H + L + A L A L + +H A ++
Sbjct: 736 IS----------ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ-------ALRHMQASLVRTPL 757
+A A+ C + + +D Q A+ Q ++
Sbjct: 786 RRELAEAMAAQHTAE---SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842
Query: 758 QGILQLGQELKPK--SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGV 815
+ Q QE K K ++ E + E+A A + A++++++ +A+ + +
Sbjct: 843 EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902
Query: 816 K------LEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESG-RGAATQQEFYAKNSRW 868
++ + T + KA T S L KE +G R +E +
Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
Query: 869 TEGLISASKAVGWGATQLVEAADKVVLHT--GKYEELIVCSHEIAASTAQLVAASKVKAN 926
T+ + A + +E ++ + + EE E+A T + A A
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022
Query: 927 KHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVR 986
+ + +NE+ ++ + +++ D L KL+ E
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD---QELAKLRGLEAAQIKE 1079
Query: 987 VLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPR 1031
+ EL +T++ + +L + K+H A SG+ E T P+
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEH---ASGSGAQSEAAGRTEPTGPK 1121
Score = 76.6 bits (187), Expect = 1e-13
Identities = 148/695 (21%), Positives = 273/695 (39%), Gaps = 57/695 (8%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
+D ++ LK++ + +++L + + ++ L+ QV L L+++ +Q ++ E
Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576
Query: 412 LRHELAQLRAAQLEGERSQGLREE--AERKASATEARYNKLKEKHSELVHVHAELLRKN- 468
R + AQ A E ER LRE A ++ A E KEK ++L + +L N
Sbjct: 577 TRQDHAQQLATAAE-EREASLRERDAALKQLEALE------KEKAAKLEILQQQLQVANE 629
Query: 469 ADTAKQLTVTQQSQE--EVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAG 526
A + Q +VTQ +E E++R E+L VE ++E E Q+ +L+ +L ++
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH----EAQAQVAELELQLRSEQQ 685
Query: 527 ELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSR 586
+ + +Q + +L + ++L K +L R+ L Q + E +A
Sbjct: 686 KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745
Query: 587 EQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
++ +E+ EL+ A R+ E L+Q + VLR AEA A S+ +
Sbjct: 746 LVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805
Query: 645 PLHLRCTSSPDYLVSRAQEAL------DAVSTLEEGHAQYLTSLADASALVAALTRFSHL 698
+ Y S+ +EA + + TL+E + L +A VA + S L
Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865
Query: 699 AADTIINGGATSHLAPTDPADRLIDTCRECGARALEL---MGQLQDQQALRHMQAS---- 751
N A H R + +E RA +L + LQ++ A + +
Sbjct: 866 QISRQQNELAELHANLA----RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
Query: 752 LVRTPLQGILQLGQEL--KPKSLDVRQEE-LGAVVDKEMAATSAAIEDAVRRIEDMMNQA 808
LVR + +EL +P RQ E L ++ +T AA++ R E M N+
Sbjct: 922 LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
Query: 809 RHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRW 868
+ + ++ + RL + +E A + +
Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 869 TEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKH 928
+ +A+ T+ GK +EL A L AA + +
Sbjct: 1042 RVEFATLQEALAHALTE----------KEGKDQEL--------AKLRGLEAAQIKELEEL 1083
Query: 929 SPHLSRLQE-CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRV 987
+ +L+E ++ E A+ A +++ ++ + KL++Q + Q +
Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQA 1143
Query: 988 LELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1022
LE++LEAER E L G +E+
Sbjct: 1144 DSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178
Score = 75.1 bits (183), Expect = 3e-13
Identities = 160/748 (21%), Positives = 289/748 (38%), Gaps = 150/748 (20%)
Query: 344 PNGSVKDDRDLQIESLKR----------EVEMLRSELEKIKLEAQRYIAQLKSQVNAL-- 391
P G + Q+ LK+ E+E+ +E K+ E IA ++ +++ L
Sbjct: 204 PMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263
Query: 392 -----------EGELEEQR--------------KQKQKALVDNEQLRHELAQLRAAQLEG 426
ELEE R KQ Q + Q+ ++ QL ++ G
Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--SEENG 321
Query: 427 ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQS----- 481
+ S LRE A +A N+L E+HS+ E L K A K+L+ Q
Sbjct: 322 DLSFKLREFASHLQQLQDA-LNELTEEHSKATQ---EWLEKQAQLEKELSAALQDKKCLE 377
Query: 482 ------QEEVARVKEQLA-----------------FQVEQVKRES--------------- 503
Q ++++++E L+ Q+E +K+E+
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 504 ---------ELKL-------EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK-SELS 546
E KL EE+ QL L +L++ L++A+E L Q+ + L+
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
Query: 547 SRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-QQRSSQEQG------ELQ 599
+++ +L++E L+ ++Q++ +L + +E +A L++ QQ+ QG +L
Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Query: 600 GRLAERESQ--EQGLRQRLLDEQFAVLRGAAA---EAAGILQDAVSKLDDPLHLRCTSSP 654
L ++E Q E +Q + A AA EA+ +DA K + L +
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617
Query: 655 DYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAP 714
+ L + Q A +A + + TS+ A A L+R + H A
Sbjct: 618 EILQQQLQVANEARDSAQ-------TSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 715 TDPAD-RLIDTCRECGARALELMGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKS 771
A+ L + A E + Q +D Q+ L+ ++ SL T +G L +E K ++
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT--KGSL---EEEKRRA 725
Query: 772 LDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEV----------NE 821
D +E+ + E+ A + ++ + +R + + R G++ + E
Sbjct: 726 ADALEEQQRCI--SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 822 RILNSCTDLMKAIRLLVTTSTSLQKEIVE-SGRGAATQQEFYAKNSRWTEGLISASKAVG 880
+ + M A + L KE+ R +QQE + + E L++ +
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 881 WGATQLVEAADKVV-------LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLS 933
+L EA +KV L + + + H A Q V +V+A K + LS
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 934 RLQECSRTVNERAANVVASTKSGQEQIE 961
LQE ++ A + + EQ E
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQE 931
Score = 70.1 bits (170), Expect = 1e-11
Identities = 157/723 (21%), Positives = 282/723 (39%), Gaps = 99/723 (13%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD------- 408
+++++RE E + +ELE+++ Q + + E E+ +++ +A D
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026
Query: 409 ------------NEQ----------LRHELAQLRAAQLEGERSQGLREEAERKASATEAR 446
NEQ L H L + E + +GL ++
Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQT 1086
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQE----EVARVKEQLAFQVEQVKR- 501
+LKE+ ++ HA ++ A + T E EV+++++Q Q EQ
Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Query: 502 ESELKLE-----EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEK 556
E L+ E E+ LE L+ +LE KA EL +Q AL+ ++ + +++ S +
Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Query: 557 DALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR----LAERE-SQEQG 611
D V + + SL+ E +S ++ +++GE + +AE E SQ+
Sbjct: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266
Query: 612 LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY---LVSRAQEALDAV 668
R RLL + A AAE + L++ V L + + +S + L S+A+ A +
Sbjct: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326
Query: 669 STLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCREC 728
L+ ++ S L T L ++ + HL A++ R
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL----PAKHLCQQLQAEQAAAEKRH- 1381
Query: 729 GARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
LE Q +QA ++A L+R +LG EL P V ++E A +
Sbjct: 1382 -REELE-----QSKQAAGGLRAELLRAQ----RELG-ELIPLRQKVAEQERTAQQLRAEK 1430
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--KAIRLLVTTSTSLQK 846
A+ A +++ ++ + + G + + + L D K ++ L +
Sbjct: 1431 ASYAEQLSMLKKAHGLLAE-ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489
Query: 847 EIVESGRGA-ATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIV 905
+ E R A +T +E +++ EG A V + E K+ T + E+L V
Sbjct: 1490 RLAEVQREAQSTARELEVMTAKY-EG---AKVKVLEERQRFQEERQKL---TAQVEQLEV 1542
Query: 906 CS-------HEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQE 958
E++ A ASKV+ K L +Q + A + A Q
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQK----LKAVQAQGGESQQEAQRLQAQLNELQA 1598
Query: 959 QIEDRD-TMDFSGLSLIKLK---------KQEMETQVRVLEL----EKTLEAERMRLGEL 1004
Q+ ++ + L + K K QE++ Q+R LE K L AE RLG
Sbjct: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
Query: 1005 RKQ 1007
+Q
Sbjct: 1659 LQQ 1661
Score = 63.9 bits (154), Expect = 8e-10
Identities = 151/690 (21%), Positives = 278/690 (40%), Gaps = 91/690 (13%)
Query: 355 QIESLKREVEMLRSELEK-------IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
Q+ +LK E E R EL++ I+ ++ I++ ++++ L L +Q Q+ V
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT-EARYNKLKEKHSELVHVHAELLR 466
++L +L+ L+ + E RKA E +L ++ + E L
Sbjct: 894 RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE 953
Query: 467 KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK---RESELKLEEKSDQLEKLKRELEA 523
+ +Q TQ + + + R EQ+ ++E+++ ES+ + +E+ Q E RE+
Sbjct: 954 EQQ--GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE---REVAR 1008
Query: 524 KAGELARAQEALSHTEQSKSELSSRLDTLSAE--------KDALSGAVRQREADLLAAQS 575
E RAQ L+ + +++EL RL E ++AL+ A+ ++E
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068
Query: 576 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGIL 635
L R EAA +E + Q +L+ +LA++E ++ A GA +EAAG
Sbjct: 1069 L-RGLEAAQIKELEELRQTVKQLKEQLAKKE------------KEHASGSGAQSEAAGRT 1115
Query: 636 QDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRF 695
+ KL+ LR S L + Q+ + +LE S A+ + + L
Sbjct: 1116 EPTGPKLE---ALRAEVSK--LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
Query: 696 SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL-ELMGQLQDQQALRHMQASLVR 754
A + G + S LA T + ++A E Q+ + + SL+
Sbjct: 1171 LEEKAQEL--GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 755 TPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVR--RIEDMMNQARHA- 811
+ + + L +++ K + +EL +V E + S +E+ +R + E N AR A
Sbjct: 1229 SLEEEVSILNRQVLEK--EGESKELKRLVMAE-SEKSQKLEERLRLLQAETASNSARAAE 1285
Query: 812 -SSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTE 870
SS ++ EV L + S +L++E+ A +E + W E
Sbjct: 1286 RSSALREEVQ--------SLREEAEKQRVASENLRQELTSQAERA---EELGQELKAWQE 1334
Query: 871 GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSP 930
+A+ QL + + ++ EL+ H A+ AA K
Sbjct: 1335 KFFQKEQAL--STLQLEHTSTQALV-----SELLPAKHLCQQLQAEQAAAEK-------R 1380
Query: 931 HLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLEL 990
H L++ + A ++ + + E I ++ K E E + L
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIP------------LRQKVAEQERTAQQLRA 1428
Query: 991 EKTLEAERMRLGELRKQHYVLAGASGSPGE 1020
EK AE++ + L+K H +LA + GE
Sbjct: 1429 EKASYAEQLSM--LKKAHGLLAEENRGLGE 1456
Score = 52.8 bits (125), Expect = 2e-06
Identities = 67/265 (25%), Positives = 121/265 (45%), Gaps = 47/265 (17%)
Query: 347 SVKDDRDLQIESLKREVEMLRSELE-----------KIKLEAQRYIAQ---LKSQVNALE 392
+V+ D + ++ ++RE + ELE K+ E QR+ + L +QV LE
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541
Query: 393 GELEEQRKQKQ---KALVDNEQL-RHELAQLRAAQLEGERSQGLREEAERKASATEARYN 448
EQ KQ + K L D++Q + + +L+A Q +G SQ + + + + +A+ +
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601
Query: 449 KLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLE 508
+ KE+ +E + E + + D K QQ+QE ++EQL +EQ+++E+
Sbjct: 1602 Q-KEQAAEHYKLQMEKAKTHYDAKK-----QQNQE----LQEQLR-SLEQLQKEN----- 1645
Query: 509 EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA 568
++L+ E E EL +A EQ+ L++++ +L A+ V +
Sbjct: 1646 ------KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ-------VAHADQ 1692
Query: 569 DLLAAQSLVRETEAALSREQQRSSQ 593
L T+A SRE Q Q
Sbjct: 1693 QLRDLGKFQVATDALKSREPQAKPQ 1717
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 80.5 bits (197), Expect = 8e-15
Identities = 144/711 (20%), Positives = 298/711 (41%), Gaps = 83/711 (11%)
Query: 351 DRDLQIESLKREVEMLRSELEKIKLEAQRYI----------AQLKSQVNA---------- 390
++ L E+ E+E L+S+L KL+ Q + +L++++ A
Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918
Query: 391 -LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK 449
LE +EE+ ++ Q + ++++ + +L QLE E S R++ + + TEA+ K
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELE-EQLEEEES--ARQKLQLEKVTTEAKLKK 975
Query: 450 LKEKHSELVHVHAELLRKN-------ADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRE 502
L+E+ L + +L ++ A+ LT ++ + +A++K + + + E
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL--E 1033
Query: 503 SELKLEEKSDQ-LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
L+ EEK Q LEK +R+LE + +L+ + ++ + +EL +L E A
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLS---DQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 562 AVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
V + A A +RE E+ +S Q+ +L+ A R E+ ++R L E+
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQE-------DLESERASRNKAEK--QKRDLGEEL 1141
Query: 622 AVLRGA---AAEAAGILQDAVSKLDDPLH-LRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 677
L+ ++ Q+ SK + ++ L+ T + AQ + + + H+Q
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ-----IQEMRQKHSQ 1196
Query: 678 YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 737
+ LA+ + A T+ N LA + L+ + + ++
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLEN--ERGELA--NEVKVLLQGKGDSEHKRKKVEA 1252
Query: 738 QLQDQQALRHMQASLVRTPL-QGILQLGQEL-KPKSLDVRQEELGAVVDKEMAATSAAIE 795
QLQ+ Q ++ + VRT L + +L EL L + + + + K+ +A + ++
Sbjct: 1253 QLQELQ-VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 796 DAVRRIEDMMNQARHASSGVKLEVNERILNSCTD-----------LMKAIRLLVTTSTSL 844
D +++ Q S+ +K +E+ NS + L K I L +
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEK--NSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 845 QKEIVESGRGAATQQEFYAKNSRWTEGL-------ISASKAVGWGATQLVEAADKVVLHT 897
+K++ +S T +E K + EGL ++A + T+L + D +++
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
Query: 898 GKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQ 957
+ + QL+A K + K++ R + +R +A ++ + +
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 958 EQIEDRDTMDFS-GLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
EQ + + ++ + L + + V ELEK+ A ++ E++ Q
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Score = 73.6 bits (179), Expect = 1e-12
Identities = 153/764 (20%), Positives = 313/764 (40%), Gaps = 138/764 (18%)
Query: 345 NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEG----------- 393
N + ++++ + LK + E + ++LE+ ++ +L+ LEG
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 394 ------ELEEQRKQKQKAL------VDNEQLRHELAQLRAAQLEGERSQGLREEAERKAS 441
EL+ Q +K++ L V+ E + +A + +LE + S+ L+E+ E + +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERA 1125
Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL-------AF 494
+ + ++ EL + EL TA Q + + ++EV +K+ L
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 495 QVEQVKRESELKLEEKSDQ----------LEKLKRELEAKAGELARAQEAL--------- 535
Q+++++++ +EE ++Q LEK K+ LE + GELA + L
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 536 ----------------SHTEQSKSELSSRLDTLSAEKDALSGAVRQREA-------DLLA 572
+ E+ ++EL+ ++ L E D ++G + Q ++ D A
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 573 AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRL---------LDEQFAV 623
+S +++T+ L Q ++++ L +L + E ++ R++L L++Q A
Sbjct: 1306 LESQLQDTQELL----QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY--LVSRAQEALDAVSTLEEGHAQYLTS 681
L A+ ++D+V L+ ++ D L R +E + A LE+ +
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 682 LAD-----------ASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGA 730
L D A L +F L A+ T + DR RE
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE-----KTISAKYAEERDRAEAEAREKET 1476
Query: 731 RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV---DKEM 787
+AL L L++ +A L R Q ++ + K +++G V +K
Sbjct: 1477 KALSLARALEEAM---EQKAELERLNKQFRTEMEDLMSSK------DDVGKSVHELEKSK 1527
Query: 788 AATSAAIEDAVRRIEDMMNQARHASSG-VKLEVNERILNSCTDLMKAIRLLVTTSTSLQK 846
A +E+ ++E++ ++ + ++LEVN + + + + ++ S +K
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA--QFERDLQGRDEQSEEKKK 1585
Query: 847 EIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQL---VEAA----DKVVLHTGK 899
++V R + E K ++A K + L +++A D+ + K
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMA---VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Query: 900 YE-ELIVCSHEI---AASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKS 955
+ ++ C E+ AS +++A +K K S E + E AA A ++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEAEMIQLQEELAAAERAKRQA 1699
Query: 956 GQEQIEDRDTM-DFSGLSLIKLKKQEMETQVRVLELEKTLEAER 998
QE+ E D + + SG + L +++ + R+ +LE+ LE E+
Sbjct: 1700 QQERDELADEIANSSGKGALAL-EEKRRLEARIAQLEEELEEEQ 1742
Score = 71.2 bits (173), Expect = 5e-12
Identities = 153/721 (21%), Positives = 285/721 (39%), Gaps = 107/721 (14%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++E + ++E E E+ Q +++ + LE +LEE+ +QK ++
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971
Query: 415 ELAQLRAAQ--LEGERSQGLREE-------AERKASATEARYN-----KLKEKHSELVHV 460
+L +L Q LE + + +E+ AE + TE KLK KH ++
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031
Query: 461 HAELLRKNADTAKQLTVTQQSQE--------EVARVKEQLA-FQVEQVKRESEL------ 505
E LR+ ++L T++ E ++A ++ Q+A +++ K+E EL
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Query: 506 -------------KLEEKSDQLEKLKRELEAKAGELARAQEAL----SHTEQSKSELSSR 548
K+ E Q+ +L+ +LE++ +A++ E K+EL
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151
Query: 549 LDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQEQGELQGRL---- 602
LD+ +A+++ S R++E ++L + + EA + +Q+ SQ EL +L
Sbjct: 1152 LDSTAAQQELRS--KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 603 ---AERESQEQGL---RQRLLDEQFAVLRGAA------AEAAGILQDAVSKLDDPLHLRC 650
A E +Q L R L +E +L+G + LQ+ K ++ +R
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR- 1268
Query: 651 TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATS 710
T D + E + L + ++ D SAL + L L + N S
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE--NRQKLS 1326
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQ---GILQLGQEL 767
+ ++ RE E L+ Q A H Q + ++ ++ G L+ +E+
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 768 KPK------SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARH-ASSGVKLEVN 820
K K L R EE A DK + T ++ + ++D++ H S LE
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDK-LEKTKTRLQ---QELDDLLVDLDHQRQSACNLEKK 1442
Query: 821 ERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG 880
++ K +LL T K E R A +E K +S ++A+
Sbjct: 1443 QK---------KFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALE 1486
Query: 881 WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV---KANKHSPHLSRLQE 937
Q E + E+L+ ++ S +L + + + + L L++
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 938 CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
+ + + + ++ + Q E RD S + KK+++ QVR E+E LE E
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFE-RDLQGRDEQS--EEKKKQLVRQVR--EMEAELEDE 1601
Query: 998 R 998
R
Sbjct: 1602 R 1602
Score = 62.4 bits (150), Expect = 2e-09
Identities = 73/334 (21%), Positives = 141/334 (42%), Gaps = 57/334 (17%)
Query: 355 QIESLKREVEMLRSELE-----KIKLE--------------------AQRYIAQLKSQVN 389
Q+E +K ++E L EL+ K++LE ++ QL QV
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592
Query: 390 ALEGELEEQRKQKQKALVDNEQLRHELAQLRA----------------AQLEGERSQGLR 433
+E ELE++RKQ+ A+ ++L +L L A +L+ + +R
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 434 EEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
E + +AS E + KE +L + AE+++ + A +Q+Q+E +++LA
Sbjct: 1653 ELDDTRASREEI-LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE----RDELA 1707
Query: 494 FQVEQVKRESELKLEEK---SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLD 550
++ + L LEEK ++ +L+ ELE + G + L ++++ L+
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767
Query: 551 TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
+ A +Q E + ++E E + + + S L+ ++A+ E Q
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT---ALEAKIAQLEEQ-- 1822
Query: 611 GLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
L + Q A + E L+D + ++DD
Sbjct: 1823 -LDNETKERQAACKQVRRTEKK--LKDVLLQVDD 1853
Score = 55.1 bits (131), Expect = 4e-07
Identities = 60/277 (21%), Positives = 126/277 (45%), Gaps = 25/277 (9%)
Query: 351 DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE 410
++ ++E L ++ +L K + + + +L+ ALE ++EE + Q E
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL-------E 1542
Query: 411 QLRHELAQLRAAQLEGE-RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
+L EL A+L E Q ++ + ER + R + +EK +LV E+ +
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERD---LQGRDEQSEEKKKQLVRQVREMEAELE 1599
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGEL- 528
D KQ ++ +++++ + L ++ + +E QL KL+ +++ EL
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR----DEAIKQLRKLQAQMKDCMRELD 1655
Query: 529 ---ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-----QREADLLAAQSLVRET 580
A +E L+ ++++ +L S + ++ L+ A R Q+E D LA +
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 581 EAALSREQQRSSQEQ-GELQGRLAERESQEQGLRQRL 616
+ AL+ E++R + + +L+ L E + + + RL
Sbjct: 1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Score = 54.7 bits (130), Expect = 5e-07
Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 26/247 (10%)
Query: 357 ESLKREVEMLRSEL----------------EKIKLEAQRYIAQLKSQVNALEG--ELEEQ 398
E KR+ + R EL EK +LEA+ IAQL+ ++ +G EL
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR--IAQLEEELEEEQGNTELIND 1750
Query: 399 RKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELV 458
R +K +D L + A + E R Q R+ E K E + + +
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 459 HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA---FQVEQVKRESEL---KLEEKSD 512
+ A++ + + Q + ++V R +++L QV+ +R +E + ++ S
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870
Query: 513 QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLA 572
+L++LKR+LE E RA + ++ + + D ++ E +L +R+ + +
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVV 1930
Query: 573 AQSLVRE 579
+ + R+
Sbjct: 1931 PRRMARK 1937
Score = 52.8 bits (125), Expect = 2e-06
Identities = 76/348 (21%), Positives = 154/348 (44%), Gaps = 33/348 (9%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+ + + + L E + + ++ + + A+ + +++ +L LEE +QK + N
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
+Q R E+ L +++ + +S E E+ A E + ++K + EL + L+
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSV---HELEKSKRALEQQVEEMKTQLEEL----EDELQATE 1552
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
D +L V Q+ +K Q ++ +SE K ++ Q+ +++ ELE + + +
Sbjct: 1553 DAKLRLEVNLQA------MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 530 RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA------A 583
A A E +L + +D+ + +D +R+ +A + + +T A A
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
Query: 584 LSREQQRS----SQEQGELQGRLAERE---SQEQGLRQRLLDE-QFAVLRGA-AAEAAGI 634
++E ++ E +LQ LA E Q Q R L DE + +GA A E
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726
Query: 635 LQDAVSKLDDPLHLR--CTSSPDYLVSRAQEALDAVST---LEEGHAQ 677
L+ +++L++ L T + + +A +D ++T LE HAQ
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774
Score = 44.3 bits (103), Expect = 6e-04
Identities = 116/563 (20%), Positives = 212/563 (37%), Gaps = 80/563 (14%)
Query: 482 QEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQS 541
QEE KE+ +V RE +L E + ++E L+ +L A E + QE L Q+
Sbjct: 843 QEEEMMAKEEELVKV----REKQLAAENRLTEMETLQSQLMA---EKLQLQEQL----QA 891
Query: 542 KSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR 601
++EL + + L A A + + DL A E L E+++ Q EL+ +
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 602 LAERESQEQGL---------RQRLLDEQFAVLRG---AAAEAAGILQDAVSKLDDPL--- 646
L E ES Q L + + L+E+ +L A+ +L+D +++ L
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 647 -----------------------HLRCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSL 682
LR + + + L+ ST L + A+ +
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 683 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
A+ +A A + A ++A + RE ++ EL L+ +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMA--------LKKIRELESQISELQEDLESE 1123
Query: 743 QALRHMQASLVRTPLQGILQLGQELKPKSLD--VRQEELGAVVDKEMAATSAAIEDAVRR 800
+A R+ R + + L EL+ +LD Q+EL + ++E+ +E+ +
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELE-DTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 801 IEDMMNQARHASSGVKLEVNERILNS---CTDLMKAIRLLVTTSTSLQKEIVESGRGAAT 857
E + + R S E+ E++ + +L KA + L L E+ +G
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 858 QQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
+ K + L G E ADKV +L V + +Q
Sbjct: 1243 SEH---KRKKVEAQLQELQVKFNEGERVRTELADKVT-------KLQVELDNVTGLLSQS 1292
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED-----RDTMDFSGLS 972
+ S S S+LQ+ + E + S + +Q+ED R+ ++ +
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKL-SLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 973 LIKLKKQEMETQVRVLELEKTLE 995
L+KQ +V +++K +E
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKME 1374
Score = 32.3 bits (72), Expect = 2.4
Identities = 66/307 (21%), Positives = 120/307 (39%), Gaps = 32/307 (10%)
Query: 715 TDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV 774
T L + C + AR E +++ +H+QA + Q I +L ++L+
Sbjct: 907 TAKKQELEEICHDLEARVEE------EEERCQHLQAEKKKMQ-QNIQELEEQLE------ 953
Query: 775 RQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--- 831
+E + E T A ++ + +Q + KL + +RI T+L
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL-LEDRIAEFTTNLTEEE 1012
Query: 832 ---KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVE 888
K++ L ++ ++ E R Q++ K R EG ++ A +
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--DSTDLSDQIAELQAQ 1070
Query: 889 AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 948
A+ + K EEL + AQ A K K + +S LQE + ERA+
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLES--ERASR 1127
Query: 949 VVASTKS---GQE----QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRL 1001
A + G+E + E DT+D + K+E E + LE+ + ++
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 1002 GELRKQH 1008
E+R++H
Sbjct: 1188 QEMRQKH 1194
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 80.5 bits (197), Expect = 8e-15
Identities = 69/270 (25%), Positives = 126/270 (46%), Gaps = 22/270 (8%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L+ + L+RE + + ++++ E Q Q + + E E+Q +++Q+ +Q
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
LR E + R QL E+ + RE+ R+ E R +L+ +
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE------------------ 380
Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
+QL QQ + E +EQ + +Q++RE +L+ E++ + ++L+RE E + E
Sbjct: 381 -QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLV-RETEAALSREQQR 590
QE ++ K E R D L E++ +R+ L Q RE L E++R
Sbjct: 440 QE--RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 591 SSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
QE+ E Q R + E +EQ L+++ +E+
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEER 527
Score = 75.5 bits (184), Expect = 3e-13
Identities = 79/273 (28%), Positives = 126/273 (46%), Gaps = 24/273 (8%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELE---EQRKQKQKALVDNEQLR 413
+ L+RE E R + + + E +R QL+ + E + EQ+ ++++ L +QLR
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 414 HELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E R QL E R Q LR E + + E R+ + E+ + E +
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE-QEERR 455
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
D K+ T++ ++E R K+QL E+ +RE LKLEE E+ + + E + +L
Sbjct: 456 DWLKREEETERHEQE--RRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLR 508
Query: 530 RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-- 587
R QE + E RL + L +RE + Q L RE E L +E
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQL-----RREQEERREQLLKREEEKRLEQERR 563
Query: 588 QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
+QR +EQ E + +L +RE E+ +QRL EQ
Sbjct: 564 EQRLKREQEERRDQLLKRE--EERRQQRLKREQ 594
Score = 73.9 bits (180), Expect = 7e-13
Identities = 77/276 (27%), Positives = 130/276 (47%), Gaps = 30/276 (10%)
Query: 357 ESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNAL--------EGELEEQRKQKQKA 405
+ L+RE ++ R + E+ K E +R +LK + E E EQ ++KQ+
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 406 LVDNEQLRHELAQLRAAQLEGE--RSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
D E+ R E R +LE E R Q R E + + E R +LK + E E
Sbjct: 477 KRDQEEERRE----RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE------E 526
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
L++ + +QL Q+ + E +E+ ++EQ +RE LK E++ + + LKRE E
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEER 585
Query: 524 KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
+ L R QE + E+ RL+ +++ +++ E + Q L++ E
Sbjct: 586 RQQRLKREQEERLEQRLKREEVE-RLE----QEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 584 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDE 619
R+QQ ++Q + RL +RE +E+ L QRL E
Sbjct: 641 ERRQQQLRREQQERREQRL-KREEEEERLEQRLKRE 675
Score = 69.7 bits (169), Expect = 1e-11
Identities = 70/269 (26%), Positives = 131/269 (48%), Gaps = 21/269 (7%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQL-RHE 415
+ L+RE ++ R + + + E +R+ + K + E L+ ++++++ L E+ RHE
Sbjct: 411 QQLRREQQLRREQQLRREQEEERH--EQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 416 LA----QLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
QL+ Q E R + L+ E E + E R +L+ + E E K +
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE----RREQRLKRQEE 524
Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
++L +S++++ R +E+ Q+ +KRE E +LE++ + ++LKRE E + +L +
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQL--LKREEEKRLEQERRE-QRLKREQEERRDQLLKR 581
Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 591
+E ++ K E RL+ ++ V + E + Q L RE R+Q
Sbjct: 582 EEE-RRQQRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 592 SQEQGELQGRLAERESQEQGLRQRLLDEQ 620
S+EQ E + + RE QE+ QRL E+
Sbjct: 636 SEEQEERRQQQLRREQQER-REQRLKREE 663
Score = 67.0 bits (162), Expect = 9e-11
Identities = 70/275 (25%), Positives = 127/275 (46%), Gaps = 26/275 (9%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
++ ++ + + L+RE E R + K + E +R +L+S+ L E EE+R+Q K +
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQLLKREEE 555
Query: 409 NEQLRHELAQLRAAQLEGERSQGLREEAER-----KASATEARYNKLKEKHSELVHVHA- 462
+ Q + E R Q L+ E ER K E +LK + E +
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 463 --ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE-KLKR 519
+ L++ ++ +S+E+ R ++QL + +Q +RE LK EE+ ++LE +LKR
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKREEEEERLEQRLKR 674
Query: 520 ELEAKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQS 575
E E + E A+E EQ++ + SR+ L +E DA V R
Sbjct: 675 EHEEERREQELAEE---EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK------ 725
Query: 576 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
+E + ++++ + + ELQ + ER ++Q
Sbjct: 726 --QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Score = 62.0 bits (149), Expect = 3e-09
Identities = 73/276 (26%), Positives = 126/276 (45%), Gaps = 28/276 (10%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ- 411
E + E E L+S E E+ E Q +L E ++QR+++Q + E+
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 412 ---------LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
LR E +L+ + + +R EE RK E R + +E+ +
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ------ 297
Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522
+ LR+ ++ ++ Q+E R +++ Q E+ +RE +L+ E++ + ++L+RE E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEE-RREQQLRREQEERREQQLRREQE 356
Query: 523 AKAGE--LARAQEALSHTEQSKSELSSRLDT-LSAEKDALSGAVRQREADLLAAQSLVRE 579
+ E L R QE +Q + E R + L E+ +RE L Q L RE
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 580 TEAALSREQQ-RSSQEQGELQGRLAERESQEQGLRQ 614
+ L REQQ R QE+ E + E+E +EQ L++
Sbjct: 417 QQ--LRREQQLRREQEE-ERHEQKHEQERREQRLKR 449
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/280 (26%), Positives = 127/280 (45%), Gaps = 29/280 (10%)
Query: 357 ESLKREVE-MLRSELEKIKLEAQ----RYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
E L++E E +LR E EK + + + R +L+ + L GE E+R+++++ ++
Sbjct: 934 EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER----EKK 989
Query: 412 LRHELAQLRAAQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNAD 470
R E +L+ E Q LREE E R+ E +Y K E E +LLR+ +
Sbjct: 990 YREE------EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE----EEQLLREERE 1039
Query: 471 TAKQLTVTQQ--SQEEVARVKEQLAFQVEQVKRESEL-----KLEEKSDQLEKLKRELEA 523
+ +Q +EE+ + +EQL + + +R EL K EE + E+L RE
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 524 KAGELARAQEALSHTE-QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRET-E 581
K R ++ E Q + E R + + L R+ E + L+RE E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 582 AALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
+E +R +E+ ELQ + +EQ R++ + Q+
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Score = 59.3 bits (142), Expect = 2e-08
Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 30/288 (10%)
Query: 360 KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 419
+ + L+ E + ++ + +R +Q + + +LEE+RK+++ L L+ +L +
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 420 RAAQLEGERSQGLREEAERKASATEARY---NKLKEKHSELVHVHAELLR---KNADTAK 473
+ E E E +R+ E +Y +L+++ +L+ E R + K
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE---------AK 524
+ Q+ ++ + E+ Q + K E +L+++ +QL + +RE K
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 525 AGELARAQEALSHTEQSKSELSSR------LDTLSAEKDALSGAVRQR------EADLLA 572
EL + +E L E+ K L R + L E++ L G R+ E
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 573 AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
+ L +E E L E ++ +++ E Q R E QE+ ++LL E+
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE---EQLLREE 1127
Score = 58.5 bits (140), Expect = 3e-08
Identities = 59/234 (25%), Positives = 103/234 (44%), Gaps = 34/234 (14%)
Query: 392 EGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATE-ARYNKL 450
E +L+E+ Q+Q+ L + E+ +L ER + RE E + R +L
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKL----------ERQELRRERQEEEQQQQRLRREQQL 306
Query: 451 KEKHSELVHVHAELLRKNADTAKQLTVTQQSQ---EEVARVKEQLAFQVEQVKRESELKL 507
+ K E E R+ + +Q ++ Q E+ R ++QL + E+ +RE +L+
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 508 EEKSDQLE-KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
E++ ++ E +L+RE + + + R ++ L +Q + E R R
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----------------R 409
Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
E L Q L RE + L REQ+ EQ Q R +R +EQ R+ L +
Sbjct: 410 EQQLRREQQLRREQQ--LRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461
Score = 57.4 bits (137), Expect = 7e-08
Identities = 73/304 (24%), Positives = 133/304 (43%), Gaps = 47/304 (15%)
Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGEL---EEQRKQKQK 404
++ ++ L+ E +R ++L+ E EK +LE +R +LK + +L EE+R+Q++
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 405 ALVDNEQLRHELAQLRAAQLEGE----------------RSQGLREEAER-------KAS 441
E+L L + +LE E R Q L+ E + +
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEV-ARVKE-----QLAFQ 495
E R +LK + E + L R++ + ++ + ++ QE+ R+K Q +
Sbjct: 651 QQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709
Query: 496 VEQVKRESELKLEEKSDQLEKLKRELEAK----AGELARAQEALSHTEQSKSELSSRLDT 551
E R+S++ + + ++ ++E E K EL +E +H +Q + E R T
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE-QRRDFT 768
Query: 552 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQG 611
+ + S RQR L+A+ +RE R ++R +E Q L E E +EQ
Sbjct: 769 WQWQAEEKSERGRQR----LSARPPLREQRERQLRAEERQQRE----QRFLPEEEEKEQR 820
Query: 612 LRQR 615
RQR
Sbjct: 821 RRQR 824
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/287 (23%), Positives = 122/287 (42%), Gaps = 29/287 (10%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
+ DRD + RE E LR E E+ +L Q + + LE + +++Q++K + D
Sbjct: 1550 RQDRDRKF----REEEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQERKFMED 1600
Query: 409 NEQLRHELAQLRAAQ-------------LEGERSQGLREEAERKASATEARYNKLKEKHS 455
+QLR + Q + Q E E Q R+E +RK E + + +E+
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR-QEREQ 1659
Query: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 515
+L H R+ ++ Q ++E R + Q+ + +RE + EE+ + +
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 516 KLKREL-EAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
+L+R+ E + QE L E+ + L E+ L R R+
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
RE + S+E R +E+ +L+ +E +EQ LR + D ++
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLR-----QEREEQQLRPQQRDGKY 1821
Score = 54.3 bits (129), Expect = 6e-07
Identities = 60/278 (21%), Positives = 134/278 (48%), Gaps = 14/278 (5%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
+ +RD + +++V R E E+ LE ++ + Q + + E +L ++R+++Q +
Sbjct: 1425 RQERDRKFREEEQQVR--RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 409 NEQ-LRHELAQLRAAQLEGE-RSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELL 465
++ E QLR + + + R Q LR +E ERK E + ++ +++ + + +L
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR-QQRQRKFLQEEQQLR 1541
Query: 466 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
R+ ++ ++ +EE +E+ Q+ + +R+ + +LEE+ + ++ +R+
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 526 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR--ETEAA 583
+L R QE Q + + L E++ ++R+ L + +R E E
Sbjct: 1602 QQL-RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 584 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
L ++ R +E+ +L +E +EQ LR++ D +F
Sbjct: 1661 LRHDRDRKFREEEQLL-----QEGEEQQLRRQERDRKF 1693
Score = 53.5 bits (127), Expect = 1e-06
Identities = 60/286 (20%), Positives = 124/286 (43%), Gaps = 24/286 (8%)
Query: 348 VKDDRDLQIESLKREVE------MLRSELEKIKLEAQRYIAQLKSQV-------NALEGE 394
+K + + + + LKRE E + R E+E+++ E +R +LK + L+ E
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKREEPEEERRQQLLKSE 637
Query: 395 LEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKH 454
+E+R+Q+Q E+ L + + +R + EE R+ E + +E+
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Query: 455 SELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQL 514
+ L AD + ++ ++E R ++ + E+ +R E +L+ + ++
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ----EQEEKRRRRESELQWQEEER 753
Query: 515 EKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
+++ E + + +A +E+ + LS+R + L RQ+ Q
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-----EQ 808
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
+ E E R +QR +E+ ELQ E + Q + Q+L +E+
Sbjct: 809 RFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQRRERAQQLQEEE 853
Score = 53.5 bits (127), Expect = 1e-06
Identities = 66/264 (25%), Positives = 118/264 (44%), Gaps = 25/264 (9%)
Query: 366 LRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL----RA 421
LR + E+ +L A+ Q + Q E E +EQR+++++ Q E QL RA
Sbjct: 790 LREQRER-QLRAEE--RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 422 AQLEGERSQGLREEAERKASATEARYNK----LKEKHSELVHVHAELLRKNADTAKQLTV 477
QL+ E GL+E+ ER+ S + R K L+E+ H K+ +
Sbjct: 847 QQLQ-EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905
Query: 478 TQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGELARAQEALS 536
Q+ +EE+ R + + + EQ ++ E +L+++ +QL + +RE R QE
Sbjct: 906 LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR-------RRQERER 958
Query: 537 HTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQG 596
+ K L E + ++RE + L +E E L E+++ +++
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 597 ELQGRLAERESQEQGLRQRLLDEQ 620
E Q R + QE+ ++LL E+
Sbjct: 1017 ERQYRKKDELQQEE---EQLLREE 1037
Score = 53.1 bits (126), Expect = 1e-06
Identities = 63/268 (23%), Positives = 114/268 (42%), Gaps = 34/268 (12%)
Query: 362 EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA 421
E ++ R E ++ E ++ + + + + L+ E + +R++ ++ + EQLR E Q +
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 422 AQLEGERS----QGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTV 477
+ E R + LR E E + + R K +E+ + LR K
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800
Query: 478 TQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSH 537
Q QE R ++QL Q +R+ + + EE+ QLE+ ++ L + RA+E +
Sbjct: 1801 EQLRQE---REEQQLRPQ----QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853
Query: 538 TEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGE 597
E+S+ E ++E Q +E E L E R Q++ +
Sbjct: 1854 QEKSRRE--------------------EQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893
Query: 598 LQGRLAERESQEQGLRQRLLD---EQFA 622
++ E +SQE RLL+ QFA
Sbjct: 1894 RHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/299 (26%), Positives = 131/299 (43%), Gaps = 45/299 (15%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ---LKSQVNALEGELEEQRK----- 400
+++ +LQ E E ++LR E EK + E +R + L+ Q E+QR
Sbjct: 1171 REEEELQQE----EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 401 ---QKQKALVDN---------EQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARY 447
+K+ A+ DN EQ R E +QLR Q + + L E+ ER R+
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+ E +L R+ AK+ ++SQEE ++E+ + ++ ++E++ K
Sbjct: 1287 QQRDRHFPE----EEQLEREEQKEAKRRD--RKSQEEKQLLREER--EEKRRRQETDRKF 1338
Query: 508 EEKSDQL-EKLKRELEAKAGELARAQEALSHTEQSKS--ELSSRLDTLSAEKDALSGA-- 562
E+ L E+ ++ L + + +E L H EQ + E RL E+ L
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 563 --VRQREADLLAAQSL-VRETEAALSREQQRSSQEQGELQGRLAERE----SQEQGLRQ 614
++RE L + RE E LSR+++ + E Q R ERE +EQ LRQ
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Score = 52.0 bits (123), Expect = 3e-06
Identities = 77/282 (27%), Positives = 122/282 (43%), Gaps = 39/282 (13%)
Query: 347 SVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
S K +R Q + +R+ E+ R E + E +R A E +L+ + + +
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERR----------AEEEQLQSCKGHETEEF 204
Query: 407 VDNEQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
D EQLR EL +LR E E+ Q RE +R E + + +E +L
Sbjct: 205 PDEEQLRRRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRET----------VL 253
Query: 466 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
RK + ++ Q Q E+ +EQL ++E+ + E + EE+ Q + +++L K
Sbjct: 254 RKEEEKLQE--EEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Query: 526 GELARAQEALSHTEQSKSELSS--RLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
E R Q+ +Q + E R L E++ +RE L Q R E
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQE------ERREQQLRREQEEERR-EQQ 363
Query: 584 LSREQQRSSQEQGELQGRLAERESQ---EQGLR--QRLLDEQ 620
L REQ+ +EQ + + RE Q EQ LR Q+L EQ
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Score = 52.0 bits (123), Expect = 3e-06
Identities = 70/278 (25%), Positives = 119/278 (42%), Gaps = 25/278 (8%)
Query: 351 DRDLQIESLKR------EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ--RKQK 402
+R+ Q E+ +R E ++LR E E+ K Q + + + L+ E EEQ R+Q+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREE-KRRRQETDRKFREEEQLLQ-EREEQPLRRQE 1357
Query: 403 QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
+ E+LRH Q + + E + R+E ERK LKE+
Sbjct: 1358 RDRKFREEELRH---QEQGRKFLEEEQRLRRQERERKF---------LKEEQQLRCQERE 1405
Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522
+ LR++ D + Q S++E R + QV + +RE + EE+ + E+ ++ E
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
+ R ++ L E+ + L E+D R++E + E E
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR---KFREQELRSQEPERKFLEEEQ 1522
Query: 583 ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
L R+Q++ Q E Q R ER Q + R R E+
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/284 (23%), Positives = 129/284 (45%), Gaps = 33/284 (11%)
Query: 361 REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420
RE E L+ E E++ L +R + + E E Q++++Q + E+ R + + +
Sbjct: 1051 REEEELQQEEEQL-LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 421 A---AQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLT 476
+L+ E Q LREE E R+ E +Y + +E E +LLR+ + ++
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE----EEQLLREEPEKRRRQE 1165
Query: 477 VTQQ--SQEEVARVKEQLAFQVEQVKR---------ESELKLEEK------SDQLEKLKR 519
+ +Q +EE+ + +EQL + ++ +R E EL+ +++ DQ LK
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Query: 520 ELEAKAGELARAQEAL---SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSL 576
+ E + R + EQ + S+L +++D Q+E D +
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 577 VRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
++ + E+Q +EQ E + R +R+SQE+ +Q L +E+
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRR--DRKSQEE--KQLLREER 1325
Score = 48.9 bits (115), Expect = 3e-05
Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 20/238 (8%)
Query: 387 QVNALEGELEEQRKQKQKALVDN----EQLRHELAQLRAAQLEGERSQGLREEAERKASA 442
Q L+ E + K+ L D +Q R E + + G+R + R+E ER+ +
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 443 TEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL----AFQVEQ 498
E + EK L + R++ + +Q Q+ +E A +EQL + E+
Sbjct: 151 GEEQ----SEKQERL--EQRDRQRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEE 203
Query: 499 VKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 558
E +L+ E L +L+R+ + + R ++ E+ + E R L E++
Sbjct: 204 FPDEEQLRRRE----LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 559 LSGAVRQREADLLAAQSLVRETE-AALSREQQRSSQEQGELQGRLAERESQEQGLRQR 615
L QR+ +L + +R+ E L RE+Q Q+Q L+ R QE+ R++
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 80.5 bits (197), Expect = 8e-15
Identities = 121/560 (21%), Positives = 227/560 (40%), Gaps = 82/560 (14%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKS---QVNALEGELEEQRKQKQKALVD 408
+D + L++++ L+S+L++++LE ++LK+ ++++L+ + ++Q A
Sbjct: 529 KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588
Query: 409 NEQLRHELAQLRAAQLE--GERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
+L+ E+A ++ Q+ G E TE ++ +KEK + A+L
Sbjct: 589 RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKG----RIAAQLQG 644
Query: 467 KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--------------------LK 506
AD Q Q QE V+E L ++E+ + E E L
Sbjct: 645 IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLT 704
Query: 507 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
L ++ QLE L++E +L QEAL EQS L + D L A L G R
Sbjct: 705 LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR 764
Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
E + Q+ EAAL + +S +E+ + R E ++E L E+ A+ G
Sbjct: 765 EDTICLLQNEKIILEAAL--QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822
Query: 627 AA---AEAAGILQDAVSKLDDPL---------HLRCTSSPDYLVSRAQ--------EALD 666
+ L+ + K+ + + R +S D L+S + E +
Sbjct: 823 QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882
Query: 667 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
L + H + T+ A+ S L + + AD + G S D + + + +
Sbjct: 883 LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMAD--LEGHLQSAQKERDEMETHLQSLQ 940
Query: 727 ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKE 786
+++ + +AL+ L + + I + Q+++ D+ + KE
Sbjct: 941 ---FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ------KE 991
Query: 787 MAATSAAIEDAV----RRIEDMMN------------QARHASSGVKLEVNERILNSCTDL 830
M A E+AV RR+++ + +A+ SS L ++ERI L
Sbjct: 992 MKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERI----QAL 1047
Query: 831 MKAIRLLVTTSTSLQKEIVE 850
++ + + T L+KE+ E
Sbjct: 1048 EAELQAVSHSKTLLEKELQE 1067
Score = 73.9 bits (180), Expect = 7e-13
Identities = 111/468 (23%), Positives = 206/468 (44%), Gaps = 72/468 (15%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK-----------QKQKA 405
E+LK+++E L+ E K E ++ + +L S + + + E++ + K + Q+A
Sbjct: 954 EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
Query: 406 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
L E EL QLRA + S L E + A EA + HS+ + + EL
Sbjct: 1014 LAAKEAADAELGQLRAQGGSSDSSLALHERIQ----ALEAELQAVS--HSKTL-LEKELQ 1066
Query: 466 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
A T+++L ++S+E+V ++++L Q R K++ + +KL ELE +
Sbjct: 1067 EVIALTSQEL---EESREKVLELEDEL-----QESRGFRKKIKRLEESNKKLALELEHEK 1118
Query: 526 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALS 585
G+L L + + E +S L+T A+ +READL+ L + +A L
Sbjct: 1119 GKLT----GLGQSNAALREHNSILET----------ALAKREADLV---QLNLQVQAVLQ 1161
Query: 586 REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDP 645
R+++ Q + +Q A E +++ + L EQ A + A + A +L +
Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNS--LKEQVAAAKVEAGHNRRHFKAASLELSEV 1219
Query: 646 LHLRCTSSPDYLVSRAQEALDAVSTLEEGH----AQYLTSLADASALVAALTR--FSHLA 699
+ + ++LV + Q D + E H AQ+ LA+A A + L + L+
Sbjct: 1220 --KKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLS 1277
Query: 700 ADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQG 759
+ N + D +R I ++L+ L +QQ R L+G
Sbjct: 1278 KQPVGNQEMENLKWEVDQKEREI--------QSLKQQLDLTEQQG---------RKELEG 1320
Query: 760 ILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQ 807
+ QL Q +K L++ QE+L ++ K+ A + + ++ ++ Q
Sbjct: 1321 LQQLLQNVK-SELEMAQEDL-SMTQKDKFMLQAKVSELKNNMKTLLQQ 1366
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/280 (24%), Positives = 130/280 (46%), Gaps = 27/280 (9%)
Query: 353 DLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQR--KQKQKALVDNE 410
+ +++++ +L EL+++ + + + + +V LE EL+E R ++K K L ++
Sbjct: 1048 EAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESN 1107
Query: 411 -----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+L HE +L G+ + LRE +A R L + + + V A L
Sbjct: 1108 KKLALELEHEKGKLTGL---GQSNAALREHNSILETALAKREADLVQLN---LQVQAVLQ 1161
Query: 466 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
RK + + + Q Q + + KE++ EQV + K+E + +R +A +
Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQV---AAAKVEAGHN-----RRHFKAAS 1213
Query: 526 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRETE 581
EL+ ++ L E +L + D L + S + Q +A+L A Q L ++ +
Sbjct: 1214 LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLD 1273
Query: 582 AALSREQQRSSQEQGELQGRLAERESQEQGLRQRL-LDEQ 620
LS+ Q +QE L+ + ++E + Q L+Q+L L EQ
Sbjct: 1274 EQLSK-QPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ 1312
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 16/234 (6%)
Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
K++ D Q++ L V+ L++ LEK K + + LK QV A + E R+ + A ++
Sbjct: 1163 KEEEDRQMKHL---VQALQASLEKEKEK----VNSLKEQVAAAKVEAGHNRRHFKAASLE 1215
Query: 409 NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKN 468
+++ EL Q + Q L+ EA+ ++ + +EL A+L
Sbjct: 1216 LSEVKKEL------QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQ 1269
Query: 469 ADTAKQLTVTQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
+QL+ +E+ +K +Q +++ +K++ +L ++ +LE L++ L+
Sbjct: 1270 KQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVK 1329
Query: 526 GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRE 579
EL AQE LS T++ K L +++ L L +Q + DL + R+
Sbjct: 1330 SELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383
Score = 57.0 bits (136), Expect = 9e-08
Identities = 105/474 (22%), Positives = 190/474 (40%), Gaps = 51/474 (10%)
Query: 345 NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 404
NG V+ RD S+ LE E Q + Q+ + LEG+LE + +
Sbjct: 380 NGEVRSRRDSICSSVS---------LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQ 430
Query: 405 ALVDNEQLRHELAQLRA-AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
AL + +L+ +LA L Q + E S ++ + +S + + + +
Sbjct: 431 ALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
L KNA A Q ++E+ R L +VE ++R + K + + L++++ A
Sbjct: 491 LEAKNASLASSNNDLQVAEEQYQR----LMAKVEDMQR----SMLSKDNTVHDLRQQMTA 542
Query: 524 KAGELARAQ----EALSHTEQSKSELSSRLDTLS--AEKDALSGAVRQREADLLAAQSLV 577
+L + Q S + S++E+SS ++ AL+ R R +A +
Sbjct: 543 LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVG 602
Query: 578 RETEAA----LSREQQRSSQEQGELQGRLAERE----SQEQGLRQRLLDEQFAVLRGAAA 629
+ T+A L E SQ+ E Q R + + +Q QG+ +LD++ A ++
Sbjct: 603 QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ---- 658
Query: 630 EAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALV 689
+Q+A + +++ L R R Q D+ ++LE+ Q +L +
Sbjct: 659 -----IQEAKTMVEEDLQRRLEEFEGER-ERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712
Query: 690 AALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQL---QDQQALR 746
AL + HL + + + D L E AR EL G+ +D L
Sbjct: 713 EALQQ-EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLL 771
Query: 747 HMQASLVRTPLQGILQLGQELK--PKSLDVRQEELGAVVDK---EMAATSAAIE 795
+ ++ LQ +EL + L+ EE ++K E+A S +E
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE 825
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.7 bits (195), Expect = 1e-14
Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%)
Query: 349 KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 405
K D +++ + E+ L+S++E + ++ Q+ I +L++++ LE E+E +R + KA
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 406 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 461
L EL ++ E + + E +K EA + K++ E H
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195
Query: 462 AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 502
A L +K+AD+ +L V Q+ ++E + +K + LA VE V +
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 503 -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 546
SELK +E+ Q L + L+ ++GE +R +EAL S + K +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 547 SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 587
+++ L + K+AL+ A++ + + DLL Q +E++A L R
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 588 QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 644
Q R+ E +Q R E E ++ L QRL +E + A Q ++++D
Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Query: 645 PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 699
L + T++ + + Q D + EE HA+ S +A +L L + +
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494
Query: 700 ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 743
+++ + + L + E G R EL L++ +
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 744 A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
A L H + ++R L Q ++ +++ K ++ Q E + + +D E+ +
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614
Query: 791 SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 831
+ AI E + +E +N A R A+ ++ N + L S DL
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674
Query: 832 KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 891
+ + ++ + LQ EI E AT ++ + L+ AS+ V QL+ +
Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726
Query: 892 KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 950
+++T K E + + Q ++ KA K + + E + + +A++
Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 951 ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
K+ ++ ++D + L+L KKQ + + RV ELE +E+E+ R E K
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844
Score = 68.2 bits (165), Expect = 4e-11
Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%)
Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
+K+ DLQ++ +++E E + +R +K+++ +LE + K+ +
Sbjct: 887 LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
D E++ EL + +LE E S+ ++ + E++ ATE + L E+ + L
Sbjct: 934 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 459 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
A+L + K A Q T+ EE + + K +L QV+ ++ E + + +
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 512 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
D LE+ KR+LE G+L AQE++ E K +L +L E L + +A +
Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 572 AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
Q ++E +A + E +R+S+ + E Q RE +E + +RL
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156
Query: 627 AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 683
E AG A +++ L + +TL + HA + L
Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
D V I+ A++ + L CR + EL + ++QQ
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 803
L + T +G LQ + LD +E L + + + A + IE+ R++E+
Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 804 MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
+ N HA + + C L + + LQ+ + ++ A +
Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379
Query: 861 FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 911
Y ++ + TE L A K + A + VEA + K ++ + E +
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439
Query: 912 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
+ A A K + N Q+C T E A+ + G E + ++ + S
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 972 SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
L LK++ Q + +L + + R+ EL K
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Score = 60.8 bits (146), Expect = 6e-09
Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%)
Query: 354 LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
+Q+E+ +EV E + +EL K + + ++LK ++ LE L + K+K
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 407 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 462
+ L E+A L + + + +EA ++ A E + N L + +L
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 463 EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 501
+L LR + + AK+ L + Q+S ++ K+QL F++ ++
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 502 ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 551
+ E K++E ++E+L+ E+EA+ A+A++ S + E+S RL+
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 552 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 608
A ++REA+ Q + R+ E A + + ++ ++ + L E+
Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 609 EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 663
Q ++Q+L E+ + A+ + + VSK L C + D L Q+
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 664 ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 718
L T + G Q + L + ALV+ L+R I L A
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331
Query: 719 DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 776
+ + +L+ + +++ + +A L R + ++ Q D R
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 777 EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 836
EEL K++A A E+ V +A +A + +R+ N DLM +
Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 837 LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 894
+L K+ + A ++ + E ++++G ++ A ++ +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 895 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
L T K E + EI+ T Q+ K + L++ + V + + A+ +
Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551
Query: 955 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
+ +E + + I+L+ +++++V EK E ++++ +R
Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Score = 50.1 bits (118), Expect = 1e-05
Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%)
Query: 419 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
L++A+ E E + ++EE ++ + + +EA+ +L+EK L+ +L + A+ L
Sbjct: 846 LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 476 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
++ +++ + K QL ++++V +E KLE++ +L+K +LE
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
++ + + A + ++ +E + LD L+ EK AL A +Q DL A + V
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024
Query: 579 E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 614
T+A + EQQ E +G+L Q + + E+++Q L +
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 615 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
+L ++F + + SK++D L L + +E + LEE
Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127
Query: 675 HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 733
S A A + L+R ++ + GGATS A ++ RE
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177
Query: 734 ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 784
+ M + ++ L+H A+L + + +LG+++ + L+ + E+ +D
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 785 ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
+ ++ +E R +ED +++ + K E +R++N DL L T
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289
Query: 841 STSLQKEIVES---------GRGAATQQ 859
S +++ E G+ A TQQ
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317
Score = 46.2 bits (108), Expect = 2e-04
Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%)
Query: 391 LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 449
L G LEE R K L+ Q R + A++E +R ER+ + +YN
Sbjct: 775 LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825
Query: 450 --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 505
+ KH + + ++ L K+A+T K++ +EE ++K++LA + E ++E E
Sbjct: 826 SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881
Query: 506 KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
K+ + L+ +++A+A LA A+E ++K +L +++ V +
Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930
Query: 566 READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
R D + + + L E ++ +L+ LA+ E ++ + ++
Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982
Query: 626 GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 685
E AG L + ++KL ++ ++A L+E H Q L L
Sbjct: 983 NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019
Query: 686 SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 745
V LT+ ++ +D +L G L+ ++ L
Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050
Query: 746 RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 805
R M + L+G L+L QE +D+ E+ +D+++ I + +IED
Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102
Query: 806 NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 865
+ G++L+ K I+ L L++EI A ++ +
Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 866 SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 925
SR E + + G GAT + ++ ++ + E ++ +T Q A +
Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 926 NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 985
KH+ ++ L E + + + +I+D S + + K +E
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255
Query: 986 RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 1016
R LE + K+ E E+ RL +L Q L SG
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Score = 41.2 bits (95), Expect = 0.005
Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 416
+ L+ ++ ++ E+E I EA+ + K + + E+ K++Q E+++ +
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792
Query: 417 AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 471
Q ++ QL + ++ L + +K EAR +L+ + +AE LRK+
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 472 AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 523
K+LT T++ ++ + R++ ++L +V+ KR++E + EE+S+ + KL+ ELE
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911
Query: 524 KAGELARAQEALSHTEQSKSELSSR 548
A + ++ ++ +K + SR
Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%)
Query: 346 GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 403
G V+ ++ E++K R+ E EL E ++ I +L+ V+ L+ +++ ++Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 404 KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+A EQ LA+ R Q E EEAE +A E++ NKL+ K E VH +
Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936
Query: 464 LL 465
++
Sbjct: 1937 VI 1938
Score = 38.1 bits (87), Expect = 0.045
Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%)
Query: 356 IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
+E +++++ E E++ L+ ++ I +L+++V LEGE+E ++K+ +A+ +
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 415 ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 470
+ +L Q E +R LR ++ K A Y + E+ E + + RK +
Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910
Query: 471 TAKQLTVTQQSQEEVARVKEQ 491
A++ +SQ RVK +
Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.7 bits (195), Expect = 1e-14
Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%)
Query: 349 KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 405
K D +++ + E+ L+S++E + ++ Q+ I +L++++ LE E+E +R + KA
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 406 LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 461
L EL ++ E + + E +K EA + K++ E H
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195
Query: 462 AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 502
A L +K+AD+ +L V Q+ ++E + +K + LA VE V +
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 503 -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 546
SELK +E+ Q L + L+ ++GE +R +EAL S + K +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 547 SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 587
+++ L + K+AL+ A++ + + DLL Q +E++A L R
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 588 QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 644
Q R+ E +Q R E E ++ L QRL +E + A Q ++++D
Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Query: 645 PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 699
L + T++ + + Q D + EE HA+ S +A +L L + +
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494
Query: 700 ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 743
+++ + + L + E G R EL L++ +
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 744 A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
A L H + ++R L Q ++ +++ K ++ Q E + + +D E+ +
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614
Query: 791 SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 831
+ AI E + +E +N A R A+ ++ N + L S DL
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674
Query: 832 KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 891
+ + ++ + LQ EI E AT ++ + L+ AS+ V QL+ +
Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726
Query: 892 KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 950
+++T K E + + Q ++ KA K + + E + + +A++
Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 951 ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
K+ ++ ++D + L+L KKQ + + RV ELE +E+E+ R E K
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844
Score = 68.2 bits (165), Expect = 4e-11
Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%)
Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
+K+ DLQ++ +++E E + +R +K+++ +LE + K+ +
Sbjct: 887 LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
D E++ EL + +LE E S+ ++ + E++ ATE + L E+ + L
Sbjct: 934 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 459 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
A+L + K A Q T+ EE + + K +L QV+ ++ E + + +
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 512 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
D LE+ KR+LE G+L AQE++ E K +L +L E L + +A +
Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 572 AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
Q ++E +A + E +R+S+ + E Q RE +E + +RL
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156
Query: 627 AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 683
E AG A +++ L + +TL + HA + L
Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
D V I+ A++ + L CR + EL + ++QQ
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 803
L + T +G LQ + LD +E L + + + A + IE+ R++E+
Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 804 MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
+ N HA + + C L + + LQ+ + ++ A +
Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379
Query: 861 FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 911
Y ++ + TE L A K + A + VEA + K ++ + E +
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439
Query: 912 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
+ A A K + N Q+C T E A+ + G E + ++ + S
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 972 SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
L LK++ Q + +L + + R+ EL K
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Score = 60.8 bits (146), Expect = 6e-09
Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%)
Query: 354 LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
+Q+E+ +EV E + +EL K + + ++LK ++ LE L + K+K
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 407 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 462
+ L E+A L + + + +EA ++ A E + N L + +L
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 463 EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 501
+L LR + + AK+ L + Q+S ++ K+QL F++ ++
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 502 ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 551
+ E K++E ++E+L+ E+EA+ A+A++ S + E+S RL+
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 552 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 608
A ++REA+ Q + R+ E A + + ++ ++ + L E+
Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 609 EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 663
Q ++Q+L E+ + A+ + + VSK L C + D L Q+
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 664 ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 718
L T + G Q + L + ALV+ L+R I L A
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331
Query: 719 DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 776
+ + +L+ + +++ + +A L R + ++ Q D R
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 777 EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 836
EEL K++A A E+ V +A +A + +R+ N DLM +
Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 837 LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 894
+L K+ + A ++ + E ++++G ++ A ++ +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 895 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
L T K E + EI+ T Q+ K + L++ + V + + A+ +
Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551
Query: 955 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
+ +E + + I+L+ +++++V EK E ++++ +R
Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Score = 50.1 bits (118), Expect = 1e-05
Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%)
Query: 419 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
L++A+ E E + ++EE ++ + + +EA+ +L+EK L+ +L + A+ L
Sbjct: 846 LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 476 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
++ +++ + K QL ++++V +E KLE++ +L+K +LE
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
++ + + A + ++ +E + LD L+ EK AL A +Q DL A + V
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024
Query: 579 E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 614
T+A + EQQ E +G+L Q + + E+++Q L +
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 615 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
+L ++F + + SK++D L L + +E + LEE
Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127
Query: 675 HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 733
S A A + L+R ++ + GGATS A ++ RE
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177
Query: 734 ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 784
+ M + ++ L+H A+L + + +LG+++ + L+ + E+ +D
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 785 ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
+ ++ +E R +ED +++ + K E +R++N DL L T
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289
Query: 841 STSLQKEIVES---------GRGAATQQ 859
S +++ E G+ A TQQ
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317
Score = 46.2 bits (108), Expect = 2e-04
Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%)
Query: 391 LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 449
L G LEE R K L+ Q R + A++E +R ER+ + +YN
Sbjct: 775 LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825
Query: 450 --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 505
+ KH + + ++ L K+A+T K++ +EE ++K++LA + E ++E E
Sbjct: 826 SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881
Query: 506 KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
K+ + L+ +++A+A LA A+E ++K +L +++ V +
Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930
Query: 566 READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
R D + + + L E ++ +L+ LA+ E ++ + ++
Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982
Query: 626 GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 685
E AG L + ++KL ++ ++A L+E H Q L L
Sbjct: 983 NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019
Query: 686 SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 745
V LT+ ++ +D +L G L+ ++ L
Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050
Query: 746 RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 805
R M + L+G L+L QE +D+ E+ +D+++ I + +IED
Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102
Query: 806 NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 865
+ G++L+ K I+ L L++EI A ++ +
Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 866 SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 925
SR E + + G GAT + ++ ++ + E ++ +T Q A +
Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 926 NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 985
KH+ ++ L E + + + +I+D S + + K +E
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255
Query: 986 RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 1016
R LE + K+ E E+ RL +L Q L SG
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Score = 41.2 bits (95), Expect = 0.005
Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 416
+ L+ ++ ++ E+E I EA+ + K + + E+ K++Q E+++ +
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792
Query: 417 AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 471
Q ++ QL + ++ L + +K EAR +L+ + +AE LRK+
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 472 AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 523
K+LT T++ ++ + R++ ++L +V+ KR++E + EE+S+ + KL+ ELE
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911
Query: 524 KAGELARAQEALSHTEQSKSELSSR 548
A + ++ ++ +K + SR
Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%)
Query: 346 GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 403
G V+ ++ E++K R+ E EL E ++ I +L+ V+ L+ +++ ++Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 404 KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+A EQ LA+ R Q E EEAE +A E++ NKL+ K E VH +
Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936
Query: 464 LL 465
++
Sbjct: 1937 VI 1938
Score = 38.1 bits (87), Expect = 0.045
Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%)
Query: 356 IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
+E +++++ E E++ L+ ++ I +L+++V LEGE+E ++K+ +A+ +
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 415 ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 470
+ +L Q E +R LR ++ K A Y + E+ E + + RK +
Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910
Query: 471 TAKQLTVTQQSQEEVARVKEQ 491
A++ +SQ RVK +
Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 79.0 bits (193), Expect = 2e-14
Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
+DR + S E E L K++L+ + IA ++ ++ L+GE
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089
Query: 396 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149
Query: 447 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
+ E+ EL + EL T Q + + ++EV +K+ L
Sbjct: 1150 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209
Query: 494 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
+ V+++++ L E ++QLE+ +R LEA+ EL +L
Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1269
Query: 537 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
E++++E + +L AE + +SGA+ + E+ +
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1329
Query: 572 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
+ TEA L Q Q ++ + L R+ E++ GLR++L +E AA
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1383
Query: 629 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
E AG LQ A ++L + R + L R E + V L
Sbjct: 1384 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443
Query: 672 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
E G + L DA+ LV+ L + D ++ + L + +R
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1502
Query: 725 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
RE ARAL L L+++Q R Q +R L+ +L ++ V + E
Sbjct: 1503 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1559
Query: 782 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
V ++ A A V +ED + A A ++LEV + L T + ++
Sbjct: 1560 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1612
Query: 842 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
++++ + R A +++ K + EG + KA A Q E A K +
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672
Query: 895 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
+ + E ++ + + + ++ K L E R E AA+ A +
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1730
Query: 955 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
+ Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1784
Score = 78.6 bits (192), Expect = 3e-14
Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++ + K+E+E++ SELE A GE EE +Q Q + ++L+
Sbjct: 937 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 975
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
+ +L A LE E +G R++ + + TEA+ K +E L +++L ++ +
Sbjct: 976 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1032
Query: 475 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL
Sbjct: 1033 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1092
Query: 529 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
QE + +Q EL ++L E A +RE +AAL+ Q
Sbjct: 1093 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149
Query: 589 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
+ E R+A ++++Q +R L E+ LRG ++ Q+ SK +
Sbjct: 1150 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1200
Query: 646 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
+ L+ T + +R EA AV L + H Q L LA+ TR +
Sbjct: 1201 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255
Query: 699 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
A + + +S + T R+ G R LEL QLQ+ Q R R
Sbjct: 1256 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1301
Query: 756 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
LQ Q EL+ S + + E + + KE+++T A + DA +++ S
Sbjct: 1302 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1361
Query: 814 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
V+ + E++ +A R L T L +++ E+G G ++
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1421
Query: 861 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
+ T+ L ++ V G +L + D + + +L+ + QL
Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
+A K + R + R ER A ++ T++ +E+ E R+ ++ L
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1538
Query: 974 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
L + + V ELE+ +LR Q
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1572
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)
Query: 387 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A
Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 930
Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
A E R +L + EL V +EL A ++ ++Q Q E R+++ + +
Sbjct: 931 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 978
Query: 502 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
E E LE + +KL+ E ++ + +E L E S+LS L S
Sbjct: 979 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038
Query: 562 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
+ E + + L + EA ++ R++++ QE +L+ RL E QEQ +
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
Q+ E+ G E LQ A+++ +D
Sbjct: 1099 QQQRAEELRAQLGRKEEE---LQAALARAED 1126
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1665
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E+ +L +++A E L E E ++ E +++ +E L + AE+LR
Sbjct: 1666 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
+ A +Q+Q++ ++++A +V LEE KR+LE + G+L
Sbjct: 1720 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1767
Query: 530 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
E EQS SEL + ++++L+ E A + E+ + ++E
Sbjct: 1768 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1823
Query: 582 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
L E + R L+ +LA+ E Q EQ R+R+L
Sbjct: 1824 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1864
Score = 53.9 bits (128), Expect = 8e-07
Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)
Query: 346 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL
Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721
Query: 396 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
+ +++A D +++ E+A +AA QLEG Q L EE E + S +E
Sbjct: 1722 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1780
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++
Sbjct: 1781 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1840
Query: 507 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
+ +L + + +LE + E + + + E+ E+ +++ D L + +
Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1900
Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
+ + + E E SR Q + Q EL+ ES + LR RL
Sbjct: 1901 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953
Score = 52.0 bits (123), Expect = 3e-06
Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
E L E +L RY +L QV +L EL +R KA +QL ++ +LR
Sbjct: 1768 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826
Query: 424 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
GE G R + +A E++ + +E+ + + +L+R+ K++ +
Sbjct: 1827 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1881
Query: 481 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++
Sbjct: 1882 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930
Query: 541 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
+++ ++++ E L +R+ + + R E S E+ +Q
Sbjct: 1931 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 79.0 bits (193), Expect = 2e-14
Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
+DR + S E E L K++L+ + IA ++ ++ L+GE
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081
Query: 396 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141
Query: 447 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
+ E+ EL + EL T Q + + ++EV +K+ L
Sbjct: 1142 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201
Query: 494 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
+ V+++++ L E ++QLE+ +R LEA+ EL +L
Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1261
Query: 537 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
E++++E + +L AE + +SGA+ + E+ +
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1321
Query: 572 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
+ TEA L Q Q ++ + L R+ E++ GLR++L +E AA
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1375
Query: 629 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
E AG LQ A ++L + R + L R E + V L
Sbjct: 1376 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435
Query: 672 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
E G + L DA+ LV+ L + D ++ + L + +R
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1494
Query: 725 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
RE ARAL L L+++Q R Q +R L+ +L ++ V + E
Sbjct: 1495 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1551
Query: 782 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
V ++ A A V +ED + A A ++LEV + L T + ++
Sbjct: 1552 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1604
Query: 842 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
++++ + R A +++ K + EG + KA A Q E A K +
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664
Query: 895 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
+ + E ++ + + + ++ K L E R E AA+ A +
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1722
Query: 955 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
+ Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1776
Score = 78.6 bits (192), Expect = 3e-14
Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++ + K+E+E++ SELE A GE EE +Q Q + ++L+
Sbjct: 929 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 967
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
+ +L A LE E +G R++ + + TEA+ K +E L +++L ++ +
Sbjct: 968 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1024
Query: 475 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL
Sbjct: 1025 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1084
Query: 529 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
QE + +Q EL ++L E A +RE +AAL+ Q
Sbjct: 1085 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141
Query: 589 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
+ E R+A ++++Q +R L E+ LRG ++ Q+ SK +
Sbjct: 1142 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1192
Query: 646 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
+ L+ T + +R EA AV L + H Q L LA+ TR +
Sbjct: 1193 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247
Query: 699 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
A + + +S + T R+ G R LEL QLQ+ Q R R
Sbjct: 1248 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1293
Query: 756 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
LQ Q EL+ S + + E + + KE+++T A + DA +++ S
Sbjct: 1294 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1353
Query: 814 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
V+ + E++ +A R L T L +++ E+G G ++
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1413
Query: 861 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
+ T+ L ++ V G +L + D + + +L+ + QL
Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
+A K + R + R ER A ++ T++ +E+ E R+ ++ L
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1530
Query: 974 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
L + + V ELE+ +LR Q
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1564
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)
Query: 387 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A
Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 922
Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
A E R +L + EL V +EL A ++ ++Q Q E R+++ + +
Sbjct: 923 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 970
Query: 502 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
E E LE + +KL+ E ++ + +E L E S+LS L S
Sbjct: 971 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030
Query: 562 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
+ E + + L + EA ++ R++++ QE +L+ RL E QEQ +
Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1090
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
Q+ E+ G E LQ A+++ +D
Sbjct: 1091 QQQRAEELRAQLGRKEEE---LQAALARAED 1118
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1657
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E+ +L +++A E L E E ++ E +++ +E L + AE+LR
Sbjct: 1658 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
+ A +Q+Q++ ++++A +V LEE KR+LE + G+L
Sbjct: 1712 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1759
Query: 530 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
E EQS SEL + ++++L+ E A + E+ + ++E
Sbjct: 1760 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1815
Query: 582 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
L E + R L+ +LA+ E Q EQ R+R+L
Sbjct: 1816 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1856
Score = 53.9 bits (128), Expect = 8e-07
Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)
Query: 346 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713
Query: 396 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
+ +++A D +++ E+A +AA QLEG Q L EE E + S +E
Sbjct: 1714 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1772
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++
Sbjct: 1773 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1832
Query: 507 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
+ +L + + +LE + E + + + E+ E+ +++ D L + +
Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1892
Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
+ + + E E SR Q + Q EL+ ES + LR RL
Sbjct: 1893 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945
Score = 52.0 bits (123), Expect = 3e-06
Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
E L E +L RY +L QV +L EL +R KA +QL ++ +LR
Sbjct: 1760 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818
Query: 424 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
GE G R + +A E++ + +E+ + + +L+R+ K++ +
Sbjct: 1819 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1873
Query: 481 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++
Sbjct: 1874 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922
Query: 541 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
+++ ++++ E L +R+ + + R E S E+ +Q
Sbjct: 1923 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 79.0 bits (193), Expect = 2e-14
Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
+DR + S E E L K++L+ + IA ++ ++ L+GE
Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1122
Query: 396 EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
E ++Q + E+LR +L A RA G R+Q L+ E +A+ EA+
Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182
Query: 447 YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
+ E+ EL + EL T Q + + ++EV +K+ L
Sbjct: 1183 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242
Query: 494 FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
+ V+++++ L E ++QLE+ +R LEA+ EL +L
Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1302
Query: 537 HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
E++++E + +L AE + +SGA+ + E+ +
Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1362
Query: 572 AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
+ TEA L Q Q ++ + L R+ E++ GLR++L +E AA
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1416
Query: 629 AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
E AG LQ A ++L + R + L R E + V L
Sbjct: 1417 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476
Query: 672 EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
E G + L DA+ LV+ L + D ++ + L + +R
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1535
Query: 725 CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
RE ARAL L L+++Q R Q +R L+ +L ++ V + E
Sbjct: 1536 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1592
Query: 782 VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
V ++ A A V +ED + A A ++LEV + L T + ++
Sbjct: 1593 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1645
Query: 842 TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
++++ + R A +++ K + EG + KA A Q E A K +
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1705
Query: 895 LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
+ + E ++ + + + ++ K L E R E AA+ A +
Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1763
Query: 955 SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
+ Q++ E D + LS + +++ + + R+ +LE+ LE E+ EL Y
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1817
Score = 78.6 bits (192), Expect = 3e-14
Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++ + K+E+E++ SELE A GE EE +Q Q + ++L+
Sbjct: 970 RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 1008
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
+ +L A LE E +G R++ + + TEA+ K +E L +++L ++ +
Sbjct: 1009 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1065
Query: 475 LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
L + Q+ EE +VK +L ++ E L+ EEK Q LEKLKR L+ ++ EL
Sbjct: 1066 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1125
Query: 529 ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
QE + +Q EL ++L E A +RE +AAL+ Q
Sbjct: 1126 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182
Query: 589 QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
+ E R+A ++++Q +R L E+ LRG ++ Q+ SK +
Sbjct: 1183 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1233
Query: 646 L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
+ L+ T + +R EA AV L + H Q L LA+ TR +
Sbjct: 1234 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288
Query: 699 AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
A + + +S + T R+ G R LEL QLQ+ Q R R
Sbjct: 1289 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1334
Query: 756 PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
LQ Q EL+ S + + E + + KE+++T A + DA +++ S
Sbjct: 1335 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1394
Query: 814 GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
V+ + E++ +A R L T L +++ E+G G ++
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1454
Query: 861 FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
+ T+ L ++ V G +L + D + + +L+ + QL
Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
+A K + R + R ER A ++ T++ +E+ E R+ ++ L
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1571
Query: 974 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
L + + V ELE+ +LR Q
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1605
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)
Query: 387 QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
QV + L+ + ++ QK +Q E+ +L R AQLE ER+ + LR EAE A
Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 963
Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
A E R +L + EL V +EL A ++ ++Q Q E R+++ + +
Sbjct: 964 AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 1011
Query: 502 ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
E E LE + +KL+ E ++ + +E L E S+LS L S
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071
Query: 562 AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
+ E + + L + EA ++ R++++ QE +L+ RL E QEQ +
Sbjct: 1072 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1131
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
Q+ E+ G E LQ A+++ +D
Sbjct: 1132 QQQRAEELRAQLGRKEEE---LQAALARAED 1159
Score = 62.0 bits (149), Expect = 3e-09
Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
++R Q+ R+ E+ R E K QR +A + LEGELEE + Q A
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1698
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E+ +L +++A E L E E ++ E +++ +E L + AE+LR
Sbjct: 1699 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
+ A +Q+Q++ ++++A +V LEE KR+LE + G+L
Sbjct: 1753 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1800
Query: 530 RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
E EQS SEL + ++++L+ E A + E+ + ++E
Sbjct: 1801 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1856
Query: 582 AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
L E + R L+ +LA+ E Q EQ R+R+L
Sbjct: 1857 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1897
Score = 53.9 bits (128), Expect = 8e-07
Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)
Query: 346 GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
G K++ Q+ ++ +++ L E+E+ + E+++ + L+++V L+ EL
Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1754
Query: 396 EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
+ +++A D +++ E+A +AA QLEG Q L EE E + S +E
Sbjct: 1755 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1813
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
++ ++ ++ + EL + + +AK + QQ + ++ ++ +L + + ++
Sbjct: 1814 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1873
Query: 507 LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
+ +L + + +LE + E + + + E+ E+ +++ D L + +
Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1933
Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
+ + + E E SR Q + Q EL+ ES + LR RL
Sbjct: 1934 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986
Score = 52.0 bits (123), Expect = 3e-06
Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
E L E +L RY +L QV +L EL +R KA +QL ++ +LR
Sbjct: 1801 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859
Query: 424 LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
GE G R + +A E++ + +E+ + + +L+R+ K++ +
Sbjct: 1860 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1914
Query: 481 SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
EE RV +QL Q LE+ + ++++LKR+LE E +RAQ ++
Sbjct: 1915 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963
Query: 541 SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
+++ ++++ E L +R+ + + R E S E+ +Q
Sbjct: 1964 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 79.0 bits (193), Expect = 2e-14
Identities = 157/718 (21%), Positives = 295/718 (41%), Gaps = 117/718 (16%)
Query: 355 QIE-SLKREVEML--RSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALV 407
QIE + KRE E L R +LE+ L+ + +A L+ + EL EQ ++ KQK
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLREEA----ERKASATEARYNKLKEKHSELVHVHAE 463
+ + + E+ L ++ +S+ E+ E + S + +++ SEL +
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
L + + ++QL + +++R K+ Q E++KR+ LEE++ L L++
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ----LEEENKAKNALAHALQS 1336
Query: 524 KAGELARAQEALSHTEQSKSELSSRLDTLSAE---------KDALSGAVRQREADLLAAQ 574
+ +E ++ K+EL L ++E DA+ EA AQ
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 575 SLVRETE---------AALSREQQRSSQEQGELQGRLAERESQEQGL--RQRLLDEQFAV 623
L E A+L + +QR E +L + S L +QR D+ A
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-QEALDAVSTLEEGHAQYLTSL 682
+ E+ L+ ++ + R S+ + + A +EALD + T++ + +
Sbjct: 1457 WKTKCEESQAELEASLKES------RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510
Query: 683 ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
AD + +A G T H + + + I+ + ALE + +
Sbjct: 1511 ADLTEQIA--------------ENGKTIH--ELEKSRKQIELEKADIQLALE-----EAE 1549
Query: 743 QALRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
AL H +A ++R L Q ++ +++ K ++ Q E + + +D E+ +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609
Query: 791 SAAI------EDAVRRIEDMMNQA-RHASSGVK-------------LEVNERILNSCTDL 830
+ AI E + IE ++ A R A+ +K L +++ L DL
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA-LRGQEDL 1668
Query: 831 MKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAA 890
+ + ++ + LQ E VE R Q E K + + L+ +++ V QL+
Sbjct: 1669 KEQLAIVERRANLLQAE-VEELRATLEQTERARKLAE--QELLDSNERV-----QLLHTQ 1720
Query: 891 DKVVLHTGKYEE--LIVCSHEIA-ASTAQLVAASKVK-----ANKHSPHLSRLQECSRTV 942
+ ++HT K E L+ E+ AS A K K A + L + Q+ S +
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780
Query: 943 NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMR 1000
N+ + K Q ++++ + + G KKQ + + R+ ELE LE E+ +
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGG-----KKQIQKLETRIRELEFELEGEQKK 1833
Score = 60.5 bits (145), Expect = 8e-09
Identities = 80/291 (27%), Positives = 134/291 (46%), Gaps = 43/291 (14%)
Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
V++ DLQ++ +++E E + L+A+ QL LE +++E ++ +
Sbjct: 882 VQEKNDLQLQ--------VQAESENL-LDAEERCDQLIKAKFQLEAKIKEVTERAE---- 928
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
D E++ EL + +LE E S+ ++ + E++ ATE + L E+ S L
Sbjct: 929 DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD 987
Query: 459 HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
A+L R K A Q + EE + + K +L QVE + ES L+ E+K
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDL--ESSLEQEKKL 1045
Query: 512 D-QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADL 570
LE+ KR+LE G+L AQE++ E K +L RL E L V +
Sbjct: 1046 RVDLERNKRKLE---GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102
Query: 571 LAAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRL 616
L Q ++E +A + E +R+++ + E Q RE +E L +RL
Sbjct: 1103 LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE--LSERL 1151
Score = 54.7 bits (130), Expect = 5e-07
Identities = 116/545 (21%), Positives = 224/545 (41%), Gaps = 96/545 (17%)
Query: 419 LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
L++A+ E E + ++EE ++ + + +EA+ +L+EK LV +L + ++ L
Sbjct: 841 LKSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899
Query: 476 TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
++ +++ + K QL ++++V +E KLE++ +L+K +LE
Sbjct: 900 LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
++ + + A + ++ +E S LD L+ EK AL A +Q DL A + V
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019
Query: 579 ETEAALSREQQR-----SSQEQ----------------GEL---QGRLAERESQEQGLRQ 614
S+ +Q+ SS EQ G+L Q + + E+ +Q L +
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Query: 615 RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
RL + F + LQ V + L L+ L +R +E + +
Sbjct: 1080 RLKKKDFEYCQ---------LQSKVED-EQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129
Query: 675 HAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALE 734
A+ +D + + L+ A GG TS I+ ++ A L+
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEA------GGVTS---------TQIELNKKREAEFLK 1174
Query: 735 LMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD--- 784
L L ++ L+H M A+L + + +LG+++ + L+ + E +D
Sbjct: 1175 LRRDL-EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Query: 785 ---KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
+ ++ + A +E R +ED +++AR NE I S ++L L T +
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGK--------NEEIQRSLSELTTQKSRLQTEA 1285
Query: 842 TSLQKEIVES----GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHT 897
L +++ E + + ++Q F + L +KA A L + L
Sbjct: 1286 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Query: 898 GKYEE 902
+YEE
Sbjct: 1346 EQYEE 1350
Score = 53.1 bits (126), Expect = 1e-06
Identities = 129/689 (18%), Positives = 264/689 (38%), Gaps = 65/689 (9%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++ + E + +EL K + + ++LK ++ LE L + K+K + L
Sbjct: 922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 981
Query: 415 ELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVH----------- 459
EL+ L + R + +EA ++A A E + N L + S+L
Sbjct: 982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041
Query: 460 ---VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE---------QVKRESEL-- 505
+ +L R L + Q+S ++ K+QL +++ Q K E E
Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101
Query: 506 ------KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL 559
K++E ++E+L+ E+EA+ A+ ++ S + ELS RL+
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161
Query: 560 SGAVRQREADLLAAQSLVRETEAALSREQQRSS--QEQGELQGRLAERESQEQGLRQRLL 617
++REA+ L + + EA L E ++ ++ + L E+ Q ++Q+L
Sbjct: 1162 IELNKKREAEFLKLRRDLE--EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219
Query: 618 DEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 677
E+ + ++VSK L C + D L + + +L E Q
Sbjct: 1220 KEKSEF--KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQ 1277
Query: 678 YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 737
+A L L ++I++ + S A T + L E L
Sbjct: 1278 KSRLQTEAGELSRQLEE-----KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332
Query: 738 QLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVD--KEMAATSAAIE 795
LQ + + +G +L + L + +V Q D + A +
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392
Query: 796 DAVRRIEDMMNQ--ARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGR 853
+R++D Q A +A + +R+ DLM + + + +L K+ +
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452
Query: 854 GAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV--LHTGKYEELIVCSHEIA 911
A + ++ E + S+++ +L A ++ + L T K E + EIA
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL-EQEIA 1511
Query: 912 ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
T Q+ K + L++ + + A++ + + + +E + + +
Sbjct: 1512 DLTEQIAENGKT--------IHELEKSRKQIELEKADIQLALEEAEAALEHEE----AKI 1559
Query: 972 SLIKLKKQEMETQVRVLELEKTLEAERMR 1000
I+L+ ++++++ EK E E+++
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLK 1588
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/198 (21%), Positives = 91/198 (45%), Gaps = 18/198 (9%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
++E R+ + +K +A +LK + + LE +K ++ + D L+H
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNLEQTVKD---LQH 1796
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
L + L+G + Q ++ E + E ++K++E V + LRK K+
Sbjct: 1797 RLDEAEQLALKGGKKQ--IQKLETRIRELEFELEGEQKKNTESV----KGLRKYERRVKE 1850
Query: 475 LTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 530
LT +++ ++ V R++ ++L +V+ KR++E E+ + L K ++ EL
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH----ELEE 1906
Query: 531 AQEALSHTEQSKSELSSR 548
A+E E ++L ++
Sbjct: 1907 AEERADIAESQVNKLRAK 1924
Score = 31.6 bits (70), Expect = 4.2
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 6/51 (11%)
Query: 957 QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
Q ++ED T+ ++ +K+ E Q R+ ELE+ +EAER + KQ
Sbjct: 1092 QSKVEDEQTLG------LQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 1006 KQ 1007
Q
Sbjct: 2224 SQ 2225
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1879 RLEEQAAQH 1887
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 957 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1580
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1581 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1635
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1688
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1689 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1742
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1743 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1792
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1793 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1834
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1895 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 2011 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2056
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2028
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2329 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2383
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2384 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2436
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2437 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2555 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2608
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2609 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2651
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1711 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1769 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1826
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1887 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2061
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2173
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2294 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2345
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1719 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1836 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1886
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1941
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 2002 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2118
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2119 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 1006 KQ 1007
Q
Sbjct: 2228 SQ 2229
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1517
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1518 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1200 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1320 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1380 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1557
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1616
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1617 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1659
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1837 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1882
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1883 RLEEQAAQH 1891
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2298 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2357 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2471
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2579
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2580 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2628
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2629 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1154
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1155 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1272 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1331
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1389
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1390 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1565
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1566 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1685 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1734
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 901 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 960
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 961 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1136
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1249
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1309
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1481
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1540
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQ 1568
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 1006 KQ 1007
Q
Sbjct: 2224 SQ 2225
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1879 RLEEQAAQH 1887
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 957 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1544
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1545 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1599
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1652
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1653 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1706
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1707 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1756
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1757 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1798
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1859 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 1975 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2020
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 1992
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2293 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2347
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2348 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2400
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2401 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2519 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2572
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2573 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2615
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1675 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1733 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1790
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1851 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2025
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2137
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2258 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2309
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1683 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1800 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1850
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1905
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 1966 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2082
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2083 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 1006 KQ 1007
Q
Sbjct: 2192 SQ 2193
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1481
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1482 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1164 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1284 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1344 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1521
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1580
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1581 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1623
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1801 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1846
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1847 RLEEQAAQH 1855
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2262 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2321 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2435
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2543
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2544 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2592
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2593 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1061 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1118
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1119 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1236 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1295
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1353
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1354 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1529
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1530 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1649 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1698
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 865 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 924
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 925 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1100
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1213
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1273
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1445
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1504
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQ 1532
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1713
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1714 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1768
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1821
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1822 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1875
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1876 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1925
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1926 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1967
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 2028 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 2144 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2189
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2161
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2462 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2516
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2517 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2569
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2570 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2688 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2741
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2742 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2784
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1844 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1902 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1959
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 2020 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2194
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2306
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2427 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2478
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1852 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1969 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 2019
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 2074
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 2135 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2251
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2252 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 1006 KQ 1007
Q
Sbjct: 2361 SQ 2362
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1650
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1651 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1333 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1453 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1513 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1690
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1749
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1750 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1792
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1970 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 2015
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 2016 RLEEQAAQH 2024
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2431 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2490 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2604
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2712
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2713 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2761
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2762 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1230 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1287
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1288 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1405 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1464
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1522
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1523 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1698
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1699 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1818 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1867
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 1093
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 1094 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1269
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1382
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1442
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1614
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1673
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQ 1701
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1554
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1555 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1609
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1662
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1663 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1716
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1717 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1766
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1767 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1808
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1869 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 1985 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2030
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2002
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2303 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2357
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2358 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2410
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2411 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2529 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2582
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2583 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2625
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1685 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1743 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1800
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1861 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2035
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2147
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2268 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2319
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1693 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1810 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1860
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1915
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 1976 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2092
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2093 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Query: 1006 KQ 1007
Q
Sbjct: 2202 SQ 2203
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1491
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1492 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1174 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1234 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1294 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1354 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1531
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1590
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1591 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1633
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1811 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1856
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1857 RLEEQAAQH 1865
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2272 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2331 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2445
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2553
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2554 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2602
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2603 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1071 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1128
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1129 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1246 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1305
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1363
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1364 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1539
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1540 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1659 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1708
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 875 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 935 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1110
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1223
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1224 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1283
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1455
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1514
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQ 1542
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1562
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1563 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1617
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1670
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1671 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1724
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1725 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1774
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1775 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1816
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1877 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 1993 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2038
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2010
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2311 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2365
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2366 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2418
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2419 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2537 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2590
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2591 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2633
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1693 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1751 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1808
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1869 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2043
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2155
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2276 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2327
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1701 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1818 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1868
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1923
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 1984 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2100
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2101 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Query: 1006 KQ 1007
Q
Sbjct: 2210 SQ 2211
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1499
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1500 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1182 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1241
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1242 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1302 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1362 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1539
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1598
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1599 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1641
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1819 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1864
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1865 RLEEQAAQH 1873
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2280 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2339 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2453
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2561
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2562 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2610
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2611 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1079 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1136
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1137 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1254 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1313
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1371
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1372 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1547
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1548 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1667 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1716
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 883 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 942
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 943 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 999
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1118
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1231
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1232 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1291
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1463
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1522
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQ 1550
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 79.0 bits (193), Expect = 2e-14
Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)
Query: 354 LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
LQ+E+ +R E++ LR+ E E K +AQ +L+ QV + E+E
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 397 -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
E ++KQ+AL E+LR E A+ R Q E ER++ ++ E + EA
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1603
Query: 448 NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
+L+ K + A+L R + + + V Q +E R ++Q + E+ + E+E +L
Sbjct: 1604 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1658
Query: 508 EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
E K+++ +L+ + E A + + AQ EA E+++ E R A AV
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1711
Query: 564 RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
RQRE LA Q L ++ + A QQR + EQ EL AE E EQ +++LL+E+ A
Sbjct: 1712 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1765
Query: 624 LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
L+ AA A Q+ L+ L L S+A+ ++ ST E+ +
Sbjct: 1766 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1815
Query: 684 DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
L A RF LA + A A + A R E AR Q +
Sbjct: 1816 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1857
Query: 744 ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
A R + L L+ E+ K + E L + + E E A +
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917
Query: 801 IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
IE+ + Q R AS +LE + ++ D ++ R + +L+ ++ G A +
Sbjct: 1918 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 860 EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
E S + L S +A A Q AA++ E + + + E AA +
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033
Query: 918 VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
+ RL+E R E A + + ++ Q++++ + K
Sbjct: 2034 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2079
Query: 978 KQEMETQVRVLELEKTLEAERMRLGELR 1005
Q + EL++TL+ E+ L +LR
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Score = 77.8 bits (190), Expect = 5e-14
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+D Q ++ E+ L++ EK A A+L+ ++ + E+ + K++A ++
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996
Query: 410 EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
+ R A+ + E E +S EEA R+ A +LK K E A L
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2051
Query: 466 RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
R+ A+ +A+QL + Q++ ++ + +E+ AF V+Q ++E + L+++ L++L+ E E
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 523 AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
A A+EA E+ ++ +++ K + + R AA+ L +E E
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 583 ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
+R Q + Q AE E EQ LRQ+ L
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 617 LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
LDE+ L+ A EAA +L L R + L+ R ++
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 668 VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
E E Q A S R LA + + A + + + + R
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 727 -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
+ A L+ +L +QA R L Q QL +E + ++L+ RQ E+
Sbjct: 2352 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2406
Query: 781 AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
A ++ + R ED + A E+ E++ T+L ++ +
Sbjct: 2407 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2459
Query: 841 STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
+ +Q++ +S A +E A+ R E L +K + + ++ + +L
Sbjct: 2460 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 897 -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
+ + L+ I A+L + + K Q + + + +VA
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 952 STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
S + + + + + G+ + + Q++E Q R + E+ L E RL E L +Q
Sbjct: 2578 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2631
Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
H A+ + EEV A +++ + L P+ +H D
Sbjct: 2632 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2674
Score = 73.9 bits (180), Expect = 7e-13
Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)
Query: 364 EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
+ L +E E I+L A+ Q + Q LE EL +++ A ++L ELA++RA
Sbjct: 1734 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791
Query: 422 -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A+ E E S+ E+++++ A R+ +L E+ + L AE ++ A++
Sbjct: 1792 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1849
Query: 475 LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
Q+++ E ++ A + ++K E+E+ L+EK + E+L+R E +A + R +E
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
Query: 534 ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
Q K+++ RL L +K + +RQR E ++LA ++
Sbjct: 1910 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966
Query: 579 ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
E E L R E S+EQ EL+ + + E+ R+R +E+ A E
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 631 AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
AA + A+ +K+++ LR + + + AQEA A L+ + +
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2084
Query: 682 LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
+ + + D + + A + + + RE E +
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144
Query: 737 GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
Q ++QA QA L+ +E + ++ Q E A+ K+ A A +E
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2196
Query: 797 AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
+ E + Q ++LE + N + ++ ++ T + + ++ E
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Query: 852 GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
Q E +K E A TQ L E A+K+ + L V + E
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 910 IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
AA QL A + A + + L+E + V E K+ E ++ + +
Sbjct: 2317 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2368
Query: 970 GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
++ K++M Q+ ++TLEAER R E+
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Score = 68.6 bits (166), Expect = 3e-11
Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)
Query: 356 IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
+E L+ + E L + ++E R + L++ + E EL+ +R Q +++L
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 408 DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
+ QLR E + Q E ER+ REEAER+ + + N+ + V +
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
A+ KQ ++ + +EQ Q E ++E E
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 505 -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
++L +++Q E+ ++ LE ELAR Q + Q + EL + L + AE + L S
Sbjct: 1742 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
Query: 562 AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
A + E+ + +S R E EA RE + R+ E+ + Q +LAE ++ Q
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 614 QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
+R+L E+ A A EA + +A L + + + L A++ LEE
Sbjct: 1859 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1909
Query: 674 GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
AQ+ + + A + + L R L DT+ LA ++
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1964
Query: 727 ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
G LEL +G+++ + LR + + + Q L +E + + + R ++ A
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
++ AA+E+ V R++ + +AR + E ++ + K ++
Sbjct: 2025 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083
Query: 841 ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
+LQ+E +++ RG A A+ + E + A + Q+ EA
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2141
Query: 890 ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
E L + E A + AQ AA+ + +A + + ++ ++ + + A
Sbjct: 2142 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 947 ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
+ K EQ + L+ ++L+ +E + Q +L+ E + L+AE R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Query: 1006 KQ 1007
Q
Sbjct: 2251 SQ 2252
Score = 66.2 bits (160), Expect = 2e-10
Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)
Query: 355 QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
++E +R E R+E L +++ LE QR +A+ +Q A L+ ++E+
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 401 QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
++++A VD +Q ++ EL QLR A+++ + Q E R E R +L+ +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 454 HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
+E AE LR A+ A+ +Q+QEE R++ Q V+ ES+ K +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1540
Query: 510 KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
+ + ++K E EA A E RA +AL E RL E+ AL A R
Sbjct: 1541 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599
Query: 565 QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
EA+L + ++ E A L R E +R +Q+Q E + E E +
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Query: 609 ------EQGLRQRLLDEQFAVLRG-AAAEA 631
+ LR RL E+ A + A AEA
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Score = 65.9 bits (159), Expect = 2e-10
Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)
Query: 350 DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
D R ++E L R++ R + + +A+R Q+++ A + EQ +Q+Q L
Sbjct: 1223 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1282
Query: 407 VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
+ E+ ++ + + AQLE S + + + + +
Sbjct: 1283 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342
Query: 447 YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
Y L+ +SEL + ++ ++ ++T +++ ++ ++++ A +E+LA +E+ ++
Sbjct: 1343 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
Query: 503 SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
+E + K+ Q E+ +EL+ + E+ R +EA +Q K + L L +A +
Sbjct: 1403 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461
Query: 561 GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
RQ EA L + +R L +++ +GELQ A
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 604 -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
R+ Q++ R+R + + A A AEAA Q A+ L++ L L+ + L
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1580
Query: 658 ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
V RA++ A+ T + L S A+ +A + + H+A + A
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1639
Query: 711 HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
A+R RE R LE QL+ +ALR LQ + + K
Sbjct: 1640 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1682
Query: 771 SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
SL E+ ++E A E AVR+ E + Q ++ +L + +
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
Query: 824 LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
+ + + +LL LQ+E + + + AK E L+ S ++A
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
Query: 880 GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
+ ++ ++ G++ EL + E A A A + + + E
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859
Query: 940 RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
R + E+ A + +T+ E + I LK++E E + R+ L + +R
Sbjct: 1860 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1905
Query: 1000 RLGELRKQH 1008
RL E QH
Sbjct: 1906 RLEEQAAQH 1914
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
R L E L ++ L ++ K K++A + +LK++ L+ + E ++Q ++ D EQ
Sbjct: 2321 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
+ +LA + +G + E + + EA KL+ AE RK
Sbjct: 2380 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435
Query: 468 NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
A + ++L T+ + +E + + L Q +Q ++E +L E +LE+ K +L EAK
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2494
Query: 525 AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
+L + EQ E + + +EKD+L R E + + L ++ A
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554
Query: 583 -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
L EQQR Q+ + + RL S E+ R+ + A E Q+ + +
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2602
Query: 642 LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
L+ + + L Q + + LEE H L + +A A T+
Sbjct: 2603 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2651
Query: 702 TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
T+ NG A +P R+ A+ L+ G L ++ R Q
Sbjct: 2652 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
Score = 49.3 bits (116), Expect = 2e-05
Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
L I + E+LR+ E++K EAQ A L ++ A + L++ R Q + + LR
Sbjct: 1120 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1177
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
EL R AQ GER Q E + + R +L E+ ++ R+ +
Sbjct: 1178 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
QL ++S + + + + EQ++ + E+ Q + L E+E ++
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
Q + + +L T A+ + + S +V Q DL
Sbjct: 1295 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1354
Query: 571 -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
L +Q + ET + E++ + Q++ E + RLAE E+ + +QR L E A +
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1412
Query: 628 AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
A A LQ ++ + + R ++ D + + + A+ A A
Sbjct: 1413 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
Query: 688 LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
+ R L A GGA L A A+ R+ A L Q
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529
Query: 739 LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
+QD+ + AS V+ Q LQ +EL+ ++ + + A V++
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1588
Query: 789 ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
A+E A R E + Q++ AS K ER L + +R Q E
Sbjct: 1589 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 849 VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
+ A + E + A R ++ K++ A + E A++ GK E
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 902 ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
E V E+A +L ++ L+ QE R + A T+ G++Q
Sbjct: 1708 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1757
Query: 960 -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
+E+ + K+QE+E ++ + E + L A + R E
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Score = 45.1 bits (105), Expect = 4e-04
Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)
Query: 357 ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
+SL+R+V+++RS +K E QR + +L Q + + + + + +
Sbjct: 924 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 983
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
E + QL QG +EE+ + +E + +L+ + E VH L +
Sbjct: 984 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1040
Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
+ A++ Q++ E L V ++ E+E L L E S L+ ELE G+
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 528 LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
L + + + T+ ++ L + + L E A+ + + EA +
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1159
Query: 574 QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
+ L + EA R++ R +QE GE LQ R ER+ + + R+R LL+ AVL
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219
Query: 625 -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
R E G + DPL + R QE + A+ + +
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1272
Query: 680 TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
L AL+ + R A IN L +L +
Sbjct: 1273 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1332
Query: 734 ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
+ + +Q+ LR + L Q I + + L+ + R E ++E A
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392
Query: 792 AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
A + R++ + QA+ + E+ +R+ +A S+Q+E+ +
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 852 GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
+ + + + A+ + E + + + QL EA ++ G EL +
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1504
Query: 911 AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
+ A+ A K +A + + L R +Q+ S+ + + + K+ E ++
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1563
Query: 970 GLSLIKLKKQEMETQVRVLELEKTLEAE 997
L ++L+ +E E ++R E+E+ + +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQ 1591
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 79.0 bits (193), Expect = 2e-14
Identities = 82/321 (25%), Positives = 148/321 (46%), Gaps = 47/321 (14%)
Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
Q++ L+R+ + +L + + E A+LK + E L+ ++++ +++L D+E LR
Sbjct: 375 QVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
+ + LE E + ++E +R EA L+E EL V A L + ++
Sbjct: 435 KEVEHMTRHLE-ESEKAMQERVQR----LEAARLSLEE---ELSRVKAAALSERGQAEEE 486
Query: 475 LTVTQ-----QSQEEVARVKEQL-------------AFQVEQVKRESELKLEEKSDQLEK 516
L + + Q+ +A ++++L Q +QV E++ ++ + Q+E
Sbjct: 487 LIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEG 546
Query: 517 LKRELEAKAGELA-RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 575
L+R LE EL+ + QE ++ + + EL + L AE LAAQ
Sbjct: 547 LRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAE---------------LAAQE 591
Query: 576 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAG 633
+RE AAL R+ + + + E L +RES+ LR+ RL + + A +R A+ A
Sbjct: 592 ALREKAAALERQLKVMASDHRE---ALLDRESENASLREKLRLREAEIARIRDEEAQRAS 648
Query: 634 ILQDAVSKLDDPLHLRCTSSP 654
LQ+AV +R S P
Sbjct: 649 FLQNAVLAYVQASPVRTLSPP 669
Score = 57.4 bits (137), Expect = 7e-08
Identities = 81/373 (21%), Positives = 152/373 (40%), Gaps = 59/373 (15%)
Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVN---ALEGELEEQRKQKQK 404
+++++ Q L ++ R E+ K + + QL+ +N ++ L+ + + +
Sbjct: 251 LREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEA 310
Query: 405 ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEA--RYNKL-------KEKHS 455
AL +EQ +L +L A + + S R+ E K EA R +KL EK+
Sbjct: 311 ALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNL 370
Query: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQ----------------- 498
L + EL RK +QL T+Q ++ + A Q E+
Sbjct: 371 LLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Query: 499 ---VK---------RESELKLEEKSDQLEKLKRELE--------AKAGELARAQEAL--- 535
+K ESE ++E+ +LE + LE A E +A+E L
Sbjct: 431 SLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKA 490
Query: 536 -----SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 590
+Q + L +L L+ +D GA Q++ + AQ+ V + + ++R
Sbjct: 491 KSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRR 550
Query: 591 SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 650
+ Q EL + ER ++ +R L ++ + AA+ A L++ + L+ L +
Sbjct: 551 LEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLKVMA 608
Query: 651 TSSPDYLVSRAQE 663
+ + L+ R E
Sbjct: 609 SDHREALLDRESE 621
Score = 39.3 bits (90), Expect = 0.020
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 354 LQIESLKREVEMLRSEL----EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
LQ+E L+R +E L+ EL ++ E R +L+ Q L+ EL Q ++KA
Sbjct: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601
Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEAR 446
QL+ + R A L+ E E R A AR
Sbjct: 602 RQLKVMASDHREALLDRESENASLREKLRLREAEIAR 638
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 78.6 bits (192), Expect = 3e-14
Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E +
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A + +LEG S L+E+ + + +A + ++ EL + EL TA Q
Sbjct: 1107 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 475 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
+ + ++EV +K+ L QV++++++ +EE ++QLE+ KR
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 520 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
+LEA+ EL Q S E++++EL+ ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1282
Query: 550 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
L E ++++G + + E D+ + S +++T+ L E ++ +L+
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 603 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
ER S + L + + L+ + L +++ LQD S ++ + R +
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 656 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
L + +E A LE+ + L D S L +F L A+
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1459
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
+S A D DR RE +AL L L++ +A ++ + +++ ++ ++
Sbjct: 1460 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 762 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
+G+ E ++L+ + EE+ ++ E+ A EDA R+E M +
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1573
Query: 813 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
+ ++ R + + R L T L+ E + AA +++
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 873 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
SA K QL + ++ + E+ EI A+ + ++ KA L
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1689
Query: 933 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
+LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+
Sbjct: 1690 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1743
Query: 993 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
LE E+ + + + + E+A STA ++ + ++
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Score = 74.7 bits (182), Expect = 4e-13
Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 411 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
QLR AQ++ Q E E ++ R+E E+KA + EA +L+E +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1698
Query: 461 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S
Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1756
Query: 512 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 572 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
AA EA +++ +++ QE E Q + +++ L++ LL
Sbjct: 1817 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Score = 65.5 bits (158), Expect = 3e-10
Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
+ LQ E K +ML E + + EA R QL+ +++ LE E+ Q K
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 407 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
+ + L ++ L + L EE E+ + T KLK KH ++ L+
Sbjct: 999 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1044
Query: 467 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
K + ++L ++ Q ++A +K QLA + E++
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104
Query: 500 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
+ ++E + + ++LE LK ELE A
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
QE + EQ + L LD + +A +RQ+ A +L + +A L +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 587 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
+Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1280
Query: 645 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
+H + + + + EA L + A + L D L+ TR L T +
Sbjct: 1281 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1338
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
+ D D ++ + L QL D + AS V +G +
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 765 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
+E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R
Sbjct: 1399 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1451
Query: 825 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
K +LL K E R A +E K L A + A
Sbjct: 1452 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1499
Query: 885 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
+ +E +K++ + E+L+ ++ + +L + + + ++L+E +
Sbjct: 1500 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 944 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
N+ A + ++ RD + ++ + E ET++ ++ L A
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617
Query: 998 RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
+ E + L S G E AI+
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK 1645
Score = 64.7 bits (156), Expect = 4e-10
Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
E ++R R ++E E EAR + +++ +L ++ ++ D +
Sbjct: 904 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
QL +EE AR K Q+E+V E+++K +++++++L K ++ LE +
Sbjct: 958 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 526 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
+ LA +E + + K SEL RL + L R+ E D
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
+ + +A ++ + + ++++ ELQ LA E + L+ Q LD
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 619 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
+ A A + + L+ ++L+D L T + + V+ ++ALD +
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 671 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
E Q + L L +F A+ + T D A L
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 726 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
+E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ +
Sbjct: 1248 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 842 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
++L ++ +S + A+T + R+ + + + + KA + +L
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 888 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
+ D +V+ +L+ + QL+A K ++K++ R + +R E+
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1483
Query: 948 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A
Sbjct: 1484 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 1000 RLGELRKQ 1007
++ E++ Q
Sbjct: 1540 QMEEMKTQ 1547
Score = 63.5 bits (153), Expect = 1e-09
Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)
Query: 355 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
L E L+ QL+ E ++ ER S + + K+K + L
Sbjct: 1341 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 472 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
K++ +TQQ +E+ A + QL +E+ +R+ +L
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 507 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
EEK+ D+ E RE E KA LARA +EAL E+
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 541 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
SK ++ + L K AL + + + L + ++ TE A R + +G+ +
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 600 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
L R+ Q + R QR L E Q A+ A + G L+D + D +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 647 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
R + +AQ E DA ++ +E A + A +L A L +
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 696 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
+ AD A + + L D R AR +L +L+++Q +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 752 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
VR Q QL EL + K L + E+ V + +T A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 793 AIEDAVRRIEDMMNQ-ARHASSGVK 816
A+E + ++E+ + Q AR + K
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATK 1842
Score = 55.8 bits (133), Expect = 2e-07
Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%)
Query: 353 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 408 DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 462
EQL +ELA R A + E R Q R+ E ++ E A +K K + L A
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 519
+L + A++ +S ++ + +++ QVE ++ +E + E+ + ++++LKR
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 520 ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
+LE E R ++ E + + + E +AL +R+
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 78.6 bits (192), Expect = 3e-14
Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E +
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A + +LEG S L+E+ + + +A + ++ EL + EL TA Q
Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 475 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
+ + ++EV +K+ L QV++++++ +EE ++QLE+ KR
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 520 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
+LEA+ EL Q S E++++EL+ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289
Query: 550 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
L E ++++G + + E D+ + S +++T+ L E ++ +L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 603 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
ER S + L + + L+ + L +++ LQD S ++ + R +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 656 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
L + +E A LE+ + L D S L +F L A+
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
+S A D DR RE +AL L L++ +A ++ + +++ ++ ++
Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 762 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
+G+ E ++L+ + EE+ ++ E+ A EDA R+E M +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580
Query: 813 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
+ ++ R + + R L T L+ E + AA +++
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 873 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
SA K QL + ++ + E+ EI A+ + ++ KA L
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696
Query: 933 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
+LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+
Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750
Query: 993 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
LE E+ + + + + E+A STA ++ + ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Score = 74.7 bits (182), Expect = 4e-13
Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 411 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
QLR AQ++ Q E E ++ R+E E+KA + EA +L+E +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705
Query: 461 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763
Query: 512 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 572 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
AA EA +++ +++ QE E Q + +++ L++ LL
Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Score = 65.5 bits (158), Expect = 3e-10
Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
+ LQ E K +ML E + + EA R QL+ +++ LE E+ Q K
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 407 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
+ + L ++ L + L EE E+ + T KLK KH ++ L+
Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051
Query: 467 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
K + ++L ++ Q ++A +K QLA + E++
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 500 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
+ ++E + + ++LE LK ELE A
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
QE + EQ + L LD + +A +RQ+ A +L + +A L +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 587 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
+Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287
Query: 645 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
+H + + + + EA L + A + L D L+ TR L T +
Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
+ D D ++ + L QL D + AS V +G +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 765 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
+E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R
Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458
Query: 825 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
K +LL K E R A +E K L A + A
Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506
Query: 885 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
+ +E +K++ + E+L+ ++ + +L + + + ++L+E +
Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 944 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
N+ A + ++ RD + ++ + E ET++ ++ L A
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
Query: 998 RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
+ E + L S G E AI+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652
Score = 64.7 bits (156), Expect = 4e-10
Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
E ++R R ++E E EAR + +++ +L ++ ++ D +
Sbjct: 911 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
QL +EE AR K Q+E+V E+++K +++++++L K ++ LE +
Sbjct: 965 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 526 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
+ LA +E + + K SEL RL + L R+ E D
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
+ + +A ++ + + ++++ ELQ LA E + L+ Q LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 619 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
+ A A + + L+ ++L+D L T + + V+ ++ALD +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 671 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
E Q + L L +F A+ + T D A L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 726 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
+E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ +
Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 842 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
++L ++ +S + A+T + R+ + + + + KA + +L
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 888 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
+ D +V+ +L+ + QL+A K ++K++ R + +R E+
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490
Query: 948 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A
Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 1000 RLGELRKQ 1007
++ E++ Q
Sbjct: 1547 QMEEMKTQ 1554
Score = 63.5 bits (153), Expect = 1e-09
Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)
Query: 355 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
L E L+ QL+ E ++ ER S + + K+K + L
Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 472 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
K++ +TQQ +E+ A + QL +E+ +R+ +L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 507 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
EEK+ D+ E RE E KA LARA +EAL E+
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 541 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
SK ++ + L K AL + + + L + ++ TE A R + +G+ +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 600 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
L R+ Q + R QR L E Q A+ A + G L+D + D +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 647 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
R + +AQ E DA ++ +E A + A +L A L +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 696 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
+ AD A + + L D R AR +L +L+++Q +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 752 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
VR Q QL EL + K L + E+ V + +T A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 793 AIEDAVRRIEDMMNQ-ARHASSGVK 816
A+E + ++E+ + Q AR + K
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849
Score = 55.8 bits (133), Expect = 2e-07
Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%)
Query: 353 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 408 DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 462
EQL +ELA R A + E R Q R+ E ++ E A +K K + L A
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 519
+L + A++ +S ++ + +++ QVE ++ +E + E+ + ++++LKR
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 520 ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
+LE E R ++ E + + + E +AL +R+
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 78.6 bits (192), Expect = 3e-14
Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)
Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
E ++E+E L+ +LE + IA L++Q+ L+ +L ++ ++ Q AL +D+E +
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
A + +LEG S L+E+ + + +A + ++ EL + EL TA Q
Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 475 LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
+ + ++EV +K+ L QV++++++ +EE ++QLE+ KR
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 520 ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
+LEA+ EL Q S E++++EL+ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289
Query: 550 DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
L E ++++G + + E D+ + S +++T+ L E ++ +L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 603 AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
ER S + L + + L+ + L +++ LQD S ++ + R +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 656 YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
L + +E A LE+ + L D S L +F L A+
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
+S A D DR RE +AL L L++ +A ++ + +++ ++ ++
Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 762 ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
+G+ E ++L+ + EE+ ++ E+ A EDA R+E M +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580
Query: 813 SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
+ ++ R + + R L T L+ E + AA +++
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 873 ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
SA K QL + ++ + E+ EI A+ + ++ KA L
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696
Query: 933 SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
+LQE ERA K E++ + SG + ++ +K+ +E R+ +LE+
Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750
Query: 993 TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
LE E+ + + + + E+A STA ++ + ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Score = 74.7 bits (182), Expect = 4e-13
Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
RD Q E +R+++ E E + ++ A + LEG+L++ Q A+ E
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 411 ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
QLR AQ++ Q E E ++ R+E E+KA + EA +L+E +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705
Query: 461 HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
AE RK AD K+ L+ Q+E R++ ++A Q+E+ E + +E S
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763
Query: 512 DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
D++ K ++ E + ELA + E ++ +L + L ++ + GAV+ + +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 572 AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
AA EA +++ +++ QE E Q + +++ L++ LL
Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Score = 65.5 bits (158), Expect = 3e-10
Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)
Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
+ LQ E K +ML E + + EA R QL+ +++ LE E+ Q K
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 407 VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
+ + L ++ L + L EE E+ + T KLK KH ++ L+
Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051
Query: 467 KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
K + ++L ++ Q ++A +K QLA + E++
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 500 -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
+ ++E + + ++LE LK ELE A
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 531 AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
QE + EQ + L LD + +A +RQ+ A +L + +A L +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 587 EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
+Q +E +L G R+ + QE +++ L+ Q L+ ++ + A ++L+D
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287
Query: 645 PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
+H + + + + EA L + A + L D L+ TR L T +
Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345
Query: 705 NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
+ D D ++ + L QL D + AS V +G +
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 765 QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
+E+ ++L + EE A DK + ++ + D+ NQ + S+ LE +R
Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458
Query: 825 NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
K +LL K E R A +E K L A + A
Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506
Query: 885 QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
+ +E +K++ + E+L+ ++ + +L + + + ++L+E +
Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 944 ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
N+ A + ++ RD + ++ + E ET++ ++ L A
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
Query: 998 RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
+ E + L S G E AI+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652
Score = 64.7 bits (156), Expect = 4e-10
Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)
Query: 354 LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
LQ+ + E++ EL+K K Q+ +LK ++ +L E++ Q+ L +L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 414 HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
E ++R R ++E E EAR + +++ +L ++ ++ D +
Sbjct: 911 AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 474 QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
QL +EE AR K Q+E+V E+++K +++++++L K ++ LE +
Sbjct: 965 QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 526 GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
+ LA +E + + K SEL RL + L R+ E D
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
+ + +A ++ + + ++++ ELQ LA E + L+ Q LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 619 EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
+ A A + + L+ ++L+D L T + + V+ ++ALD +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 671 LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
E Q + L L +F A+ + T D A L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 726 RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
+E + +L Q+Q+ Q+ + R L + +L E++ + + + E A+ +
Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 784 DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
K++A+ S+ ++D +++ Q + S+ ++ ER + + + M+A + L
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 842 TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
++L ++ +S + A+T + R+ + + + + KA + +L
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 888 EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
+ D +V+ +L+ + QL+A K ++K++ R + +R E+
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490
Query: 948 NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
++ ++ +E +E ++ ++ + K+ K EME V V ELEK+ A
Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 1000 RLGELRKQ 1007
++ E++ Q
Sbjct: 1547 QMEEMKTQ 1554
Score = 63.5 bits (153), Expect = 1e-09
Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)
Query: 355 QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
++ L+ EVE + +E E ++ + +A L SQ+ + L+E+ +QK Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
L E L+ QL+ E ++ ER S + + K+K + L
Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 472 AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
K++ +TQQ +E+ A + QL +E+ +R+ +L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 507 LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
EEK+ D+ E RE E KA LARA +EAL E+
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 541 -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
SK ++ + L K AL + + + L + ++ TE A R + +G+ +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 600 GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
L R+ Q + R QR L E Q A+ A + G L+D + D +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 647 HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
R + +AQ E DA ++ +E A + A +L A L +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 696 ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
+ AD A + + L D R AR +L +L+++Q +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 752 LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
VR Q QL EL + K L + E+ V + +T A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 793 AIEDAVRRIEDMMNQ-ARHASSGVK 816
A+E + ++E+ + Q AR + K
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849
Score = 51.6 bits (122), Expect = 4e-06
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 37/257 (14%)
Query: 353 DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
DL+ E L E+ S + EK +LEA+ IAQL+ ++ +G +E + +KA
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 408 DNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRK 467
EQL +ELA R+ ++++ R++ ER+ KE S+L + + K
Sbjct: 1772 QAEQLSNELATERST---AQKNESARQQLERQN----------KELRSKLHEMEGAVKSK 1818
Query: 468 NADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGE 527
T L + ++A+++EQ VEQ RE + + + +KLK L E
Sbjct: 1819 FKSTIAAL------EAKIAQLEEQ----VEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 528 LARAQEALSHTEQSKS---ELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRET 580
A++ E+ + +L +L+ E ++ R+ + +L A +++ RE
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 581 EAALSREQQRSSQEQGE 597
A S+ + QE +
Sbjct: 1929 NALKSKLRGPPPQETSQ 1945
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,597,125
Number of Sequences: 37866
Number of extensions: 1644812
Number of successful extensions: 16810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 1081
Number of HSP's that attempted gapping in prelim test: 7288
Number of HSP's gapped (non-prelim): 5298
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.