Guide to the Human Genome
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Search of human proteins with 48762942

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48762942 huntingtin interacting protein-1-related [Homo
sapiens]
         (1068 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]  2067   0.0  
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]   1822   0.0  
gi|38045919 huntingtin interacting protein 1 [Homo sapiens]           984   0.0  
gi|223029410 talin 1 [Homo sapiens]                                   109   2e-23
gi|156938343 talin 2 [Homo sapiens]                                   108   4e-23
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                92   3e-18
gi|21735548 centrosomal protein 2 [Homo sapiens]                       91   6e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    84   7e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         81   5e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     80   8e-15
gi|148746195 trichohyalin [Homo sapiens]                               80   8e-15
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    80   8e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    80   1e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    80   1e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           79   2e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           79   2e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           79   2e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    79   2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        79   2e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        79   2e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         79   2e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         79   2e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         79   2e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         79   2e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         79   2e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         79   2e-14
gi|21450705 leucine rich repeat containing 45 [Homo sapiens]           79   2e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    79   3e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    79   3e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    79   3e-14

>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
          Length = 1068

 Score = 2067 bits (5355), Expect = 0.0
 Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)

Query: 1    MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH 60
            MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH
Sbjct: 1    MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH 60

Query: 61   EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG 120
            EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG
Sbjct: 61   EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG 120

Query: 121  HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF 180
            HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF
Sbjct: 121  HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF 180

Query: 181  DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC 240
            DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC
Sbjct: 181  DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC 240

Query: 241  LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK 300
            LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK
Sbjct: 241  LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK 300

Query: 301  PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK 360
            PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK
Sbjct: 301  PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK 360

Query: 361  REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420
            REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR
Sbjct: 361  REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420

Query: 421  AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ 480
            AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ
Sbjct: 421  AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ 480

Query: 481  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
            SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ
Sbjct: 481  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540

Query: 541  SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG 600
            SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG
Sbjct: 541  SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG 600

Query: 601  RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR 660
            RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR
Sbjct: 601  RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR 660

Query: 661  AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR 720
            AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR
Sbjct: 661  AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR 720

Query: 721  LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG 780
            LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG
Sbjct: 721  LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG 780

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT
Sbjct: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY 900
            STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY
Sbjct: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY 900

Query: 901  EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI 960
            EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI
Sbjct: 901  EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI 960

Query: 961  EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE 1020
            EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE
Sbjct: 961  EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE 1020

Query: 1021 EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068
            EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Sbjct: 1021 EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068


>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
          Length = 1048

 Score = 1822 bits (4720), Expect = 0.0
 Identities = 949/949 (100%), Positives = 949/949 (100%)

Query: 120  GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 179
            GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM
Sbjct: 100  GHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEM 159

Query: 180  FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 239
            FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS
Sbjct: 160  FDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHS 219

Query: 240  CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 299
            CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI
Sbjct: 220  CLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHI 279

Query: 300  KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 359
            KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL
Sbjct: 280  KPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESL 339

Query: 360  KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 419
            KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL
Sbjct: 340  KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 399

Query: 420  RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 479
            RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ
Sbjct: 400  RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQ 459

Query: 480  QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 539
            QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE
Sbjct: 460  QSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE 519

Query: 540  QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
            QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ
Sbjct: 520  QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579

Query: 600  GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 659
            GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS
Sbjct: 580  GRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVS 639

Query: 660  RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 719
            RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD
Sbjct: 640  RAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPAD 699

Query: 720  RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 779
            RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL
Sbjct: 700  RLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEEL 759

Query: 780  GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 839
            GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT
Sbjct: 760  GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 819

Query: 840  TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 899
            TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK
Sbjct: 820  TSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGK 879

Query: 900  YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 959
            YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ
Sbjct: 880  YEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ 939

Query: 960  IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 1019
            IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG
Sbjct: 940  IEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPG 999

Query: 1020 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1068
            EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Sbjct: 1000 EEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY 1048


>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
          Length = 1037

 Score =  984 bits (2545), Expect = 0.0
 Identities = 531/1057 (50%), Positives = 722/1057 (68%), Gaps = 46/1057 (4%)

Query: 2    NSIKNVP---ARVLSRRP-GHSLEA-EREQFDKTQAISISKAINTQEAPVKEKHARRIIL 56
            +S+K VP    +VLSRR  G  LEA ERE F++TQ +SI+KAINTQE  VKEKHAR  IL
Sbjct: 6    SSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCIL 65

Query: 57   GTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIG 116
            GTHHEKGA TFWS    LPL S+++L WKFCHV HK+LRDGHPNVL D  RYR+ + ++ 
Sbjct: 66   GTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMS 125

Query: 117  DLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLT 176
             +WGHL + YGQL ++Y KLL TK+ +H K+P+FP  L+++D  L++A  +DVNN FQLT
Sbjct: 126  RMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLT 185

Query: 177  VEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFK 236
            VEMFDY++CEL L ++VF  L+ + +VS  ++GQCRLAPLIQVI DCSHLY YTVKLLFK
Sbjct: 186  VEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFK 245

Query: 237  LHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALA 296
            LHSCLPADTLQGHRDRF EQF  L++ F R+S++ YFKRLIQIP+LPE PPNFLRASAL+
Sbjct: 246  LHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALS 305

Query: 297  EHIKPVVVIPEEA--PEDE---EPENLIEISTGPPAGEPVVVADLFDQTFGPP------- 344
            EHI PVVVIP EA  P+ E   E ++L+++     A +  +  + FD  FG         
Sbjct: 306  EHISPVVVIPAEASSPDSEPVLEKDDLMDMD----ASQQNLFDNKFDDIFGSSFSSDPFN 361

Query: 345  ----NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK 400
                NG  KD++D  IE L RE+  L+++LE +K E+QR + QLK  V+ LE +L EQ+ 
Sbjct: 362  FNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQH 421

Query: 401  QKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHV 460
             +Q+A  D E LR EL +LR  + + E++Q    E ERKA A E RY+KLKEK+SELV  
Sbjct: 422  LRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQN 481

Query: 461  HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRE 520
            HA+LLRKNA+  KQ+++ +Q+Q ++ R K++L   +E++  + + K +E+ + LE LK+E
Sbjct: 482  HADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQE 541

Query: 521  LEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRET 580
            L     EL   Q +L  + QS++  ++    L  E+D+L      RE +L A +  +++T
Sbjct: 542  LATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDT 601

Query: 581  EAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVS 640
            +  L+                     S E+ + Q   D++  +L G+   A  ++QDA++
Sbjct: 602  QLKLA---------------------STEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN 640

Query: 641  KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAA 700
            +L++P  + C  S D+L+S        +  LE+  +QYL    D S L+ ++T  +HL +
Sbjct: 641  QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS 700

Query: 701  DTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGI 760
            D I +G  T   AP +PAD L + C++ G   L  +  L+++ +L +  ++ +R  L  I
Sbjct: 701  DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI 760

Query: 761  LQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVN 820
              +G+EL P+ LD++QEELG +VDKEMAATSAAIE A  RIE+M++++R   +GVKLEVN
Sbjct: 761  KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVN 820

Query: 821  ERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG 880
            ERIL  CT LM+AI++L+  S  LQ+EIVESGRG A+ +EFYAKNSRWTEGLISASKAVG
Sbjct: 821  ERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVG 880

Query: 881  WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSR 940
            WGAT +V+AAD VV   GK+EEL+VCSHEIAASTAQLVAASKVKA+K SP+L++LQ+ SR
Sbjct: 881  WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASR 940

Query: 941  TVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMR 1000
             VN+  A VVAST SG+ QIE+ D MDFS ++L ++K+QEM++QVRVLELE  L+ ER +
Sbjct: 941  GVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQK 1000

Query: 1001 LGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
            LGELRK+HY LAG +    E     P T    VT K+
Sbjct: 1001 LGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE 1037


>gi|223029410 talin 1 [Homo sapiens]
          Length = 2541

 Score =  109 bits (272), Expect = 2e-23
 Identities = 156/756 (20%), Positives = 295/756 (39%), Gaps = 36/756 (4%)

Query: 284  EGPPNFLRASALAEHIKPVVVIPEEAPED-----EEPENLIEISTGPPAGEPVVVADLFD 338
            E   N  +A+   E ++  V +  EA ED      E  +   +  G        +  L +
Sbjct: 1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDE 1840

Query: 339  QTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ 398
               G P GS  D +   + + K     ++  + K     +  +  L +Q+ +  G L  +
Sbjct: 1841 GPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEE-LGPLANQLTSDYGRLASE 1899

Query: 399  RKQKQKALVDNE---QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHS 455
             K    A  + E    ++H + +L           G  + +   A   +      +    
Sbjct: 1900 AKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSE 1959

Query: 456  ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE-QVKRESELKLEEKSDQL 514
            ++ HV A L   N  T   +T        +A +   + F     + RE      +  + +
Sbjct: 1960 KVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGI 2019

Query: 515  EK----LKRELEAKAGELARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREAD 569
             K    L  + +      A +QE L+   QS     +RL D +     +L     + +  
Sbjct: 2020 LKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVV 2079

Query: 570  LLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ-RLLDEQFAVLRGAA 628
            L+ A   V +    L    + ++ + G+       + S +  +     L +    +   A
Sbjct: 2080 LINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEA 2139

Query: 629  AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 688
             +    L+     +   L + C+  P    S  ++ +     +    A+ + +       
Sbjct: 2140 TKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQE 2199

Query: 689  -VAALTRFSHLAADTIINGGATSHLAPTDPAD---RLIDTCRECGARALELMGQLQ---- 740
             V A    S  A   ++     +   P    D   R +   REC    LEL+  +     
Sbjct: 2200 DVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQ 2259

Query: 741  ------DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAI 794
                   QQ   H +   V   +  ++Q  + +K     V  E+   + + E+   +AAI
Sbjct: 2260 KPSPELKQQLTGHSKR--VAGSVTELIQAAEAMKGTEW-VDPEDPTVIAENELLGAAAAI 2316

Query: 795  EDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG 854
            E A +++E +  +A+   +   L   E+IL +   +  A   LV  +++ Q+E+V  G+ 
Sbjct: 2317 EAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKV 2376

Query: 855  AATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST 914
             A        + +W++GLISA++ V      L EAA+  V      E+LI  + ++AAST
Sbjct: 2377 GAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAAST 2435

Query: 915  AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-ASTKSGQEQIEDRDTMDFSGLSL 973
            AQL+ A KVKA++ S  + RLQ     V   + N+V A+ K+   + ++ +T+      +
Sbjct: 2436 AQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKE-KM 2494

Query: 974  IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
            +    Q +  Q  +L  E+ LE  R +L ++R+Q Y
Sbjct: 2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530



 Score = 37.4 bits (85), Expect = 0.076
 Identities = 73/376 (19%), Positives = 131/376 (34%), Gaps = 88/376 (23%)

Query: 667  AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIING-----GATSHL------APT 715
            AV+T+       LT ++    L+AAL      +   ++       GA S L      A  
Sbjct: 576  AVTTISSN----LTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASA 631

Query: 716  DPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVR 775
            +P   L+      G  + EL+ Q+ +     H Q +L+                      
Sbjct: 632  EPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALM---------------------- 669

Query: 776  QEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIR 835
              +L   V    AA     +   +R ED   Q +  ++  +  ++   L +CT ++    
Sbjct: 670  --QLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAP-- 725

Query: 836  LLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKA----------VGWGATQ 885
                +S   Q+++VE+GR  A          +  EG +SAS+A          VG  AT 
Sbjct: 726  --TISSPVCQEQLVEAGRLVA----------KAVEGCVSASQAATEDGQLLRGVGAAATA 773

Query: 886  LVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNER 945
            + +A ++++ H        V +H   A  A                  R  + + T+   
Sbjct: 774  VTQALNELLQH--------VKAHATGAGPA-----------------GRYDQATDTILTV 808

Query: 946  AANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
              N+ +S     E +     +  +   L+   K + E +  +    K L A ++      
Sbjct: 809  TENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATA 868

Query: 1006 KQHYVLAGASGSPGEE 1021
            K      GA+  P  E
Sbjct: 869  KMVEAAKGAAAHPDSE 884


>gi|156938343 talin 2 [Homo sapiens]
          Length = 2542

 Score =  108 bits (269), Expect = 4e-23
 Identities = 73/241 (30%), Positives = 130/241 (53%), Gaps = 12/241 (4%)

Query: 774  VRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKA 833
            V  E+   + + E+   +A+IE A +++E +  +A+   +   L+  E+IL +   +  A
Sbjct: 2297 VDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAA 2356

Query: 834  IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKV 893
               LV ++++ Q+E+V  G+  +      A + +W++GLISA++ V    + L EAA+  
Sbjct: 2357 TSALVKSASAAQRELVAQGKVGSIPANA-ADDGQWSQGLISAARMVAAATSSLCEAANAS 2415

Query: 894  VLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-AS 952
            V      E+LI  + ++AASTAQL+ A KVKA++ S  + RLQ     V   + N+V A+
Sbjct: 2416 VQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAA 2475

Query: 953  TKSGQEQIEDRD----TMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQH 1008
             K+   + +D D    T    G++ I   ++EM      L+ E+ LE  R +L ++R+Q 
Sbjct: 2476 QKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEM------LKKERELEEARKKLAQIRQQQ 2529

Query: 1009 Y 1009
            Y
Sbjct: 2530 Y 2530



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 45/190 (23%), Positives = 80/190 (42%), Gaps = 25/190 (13%)

Query: 783 VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTST 842
           + K +   +A ++D V   ED++  AR  +  V            +DL+KA++   T+  
Sbjct: 590 MSKGVKLLAALMDDEVGSGEDLLRAARTLAGAV------------SDLLKAVQ--PTSGE 635

Query: 843 SLQKEIVESGRGAATQQEFYAK------NSRWTEGLISASKAVGWGATQLVEAADKVVL- 895
             Q  +  +G       +   +      + R+ + L+S +KAV   A  LV  A  V   
Sbjct: 636 PRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQV 695

Query: 896 --HTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL--SRLQECSRTVNERAANVVA 951
              T     +I  + + A ST+QLVA +KV +   S  +   +L E  + V+    N V 
Sbjct: 696 AEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVR 755

Query: 952 STKSGQEQIE 961
           + ++     E
Sbjct: 756 ACQAATTDSE 765


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 156/703 (22%), Positives = 270/703 (38%), Gaps = 151/703 (21%)

Query: 353  DLQIESLKREVEMLRSELEKI----------KLEAQRYIAQLKSQVNALEGELEEQRKQK 402
            +L +  L+ E   L+  L K+          KL+  R +AQL+ + +AL+G    QR+ +
Sbjct: 721  ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR---QRQAE 777

Query: 403  QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
            Q+A V  E+ +  L +LR  Q      +  R+  E      E     L+++   L H  +
Sbjct: 778  QEATVAREE-QERLEELRLEQ------EVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830

Query: 463  ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEK------------ 510
            +L  + A  ++QL+  +Q  E+  R  ++    +E+  RE E   +E             
Sbjct: 831  QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER 890

Query: 511  -----SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
                 S++  +L+ E EA  G L   Q  L+  E  + +L +    L   K+ L+G +  
Sbjct: 891  EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950

Query: 566  READLLAAQSLVRETEAALSRE--QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
                ++A Q      +A+L +E   Q+  Q + E Q  L E+ +  +   QRL  E+ A 
Sbjct: 951  LRQQIIATQE-----KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL---VSRAQEALDAVSTLEEGHAQYLT 680
             R   AE A  LQ  + +  + L  R  +  + L   ++  Q+  D    L E   Q   
Sbjct: 1006 WRELEAERAQ-LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQAL 1064

Query: 681  SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ 740
            SL ++                             T  +++L+ T       +LE+  Q +
Sbjct: 1065 SLKESEK---------------------------TALSEKLMGTRHSLATISLEMERQKR 1097

Query: 741  DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR 800
            D Q+ +    S V         L  EL+    D+R +       +E AA + A E  VRR
Sbjct: 1098 DAQSRQEQDRSTVNA-------LTSELR----DLRAQ-------REEAAAAHAQE--VRR 1137

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
            +++   QAR        +  +  L    +L   +RLL      L++E++E+ R     QE
Sbjct: 1138 LQE---QARDLG-----KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQE 1189

Query: 861  FYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAA 920
                                                            E+    A  +  
Sbjct: 1190 ----------------------------------------------GREVQRQEAGELRR 1203

Query: 921  SKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQE 980
            S  +  K    L R  E  R+  ++A +   S K   E  E +  +     + +  +  E
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263

Query: 981  METQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVA 1023
            + T ++ +E  + LEA R  L ELR+Q  +L   +   G E+A
Sbjct: 1264 LRTGLQEVERSR-LEARR-ELQELRRQMKMLDSENTRLGRELA 1304



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 149/703 (21%), Positives = 294/703 (41%), Gaps = 78/703 (11%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R LQ++ ++   E  +  L  ++    + ++  +S+  ALE +L+  R +   A+  +E 
Sbjct: 531  RQLQVQDMRGRYEASQDLLGTLR----KQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586

Query: 412  LRHELAQLRAA------------------QLEGERSQGLREEAERKASATEARYNKLKEK 453
             + E+ +LR+A                  Q + E  +  RE+ +        + ++L+E+
Sbjct: 587  AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 454  HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQ 513
              + V   A + R+   + +QL   +  +  +A+   ++   + +   + ++   EK++ 
Sbjct: 647  QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706

Query: 514  LEKLKR------ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 567
             E L +      ELE    +L RA+EA    + S S+LS+  ++L+ +K  L+  V Q E
Sbjct: 707  AEALTKAEAGRVELELSMTKL-RAEEA--SLQDSLSKLSALNESLAQDKLDLNRLVAQLE 763

Query: 568  ADLLAAQSLVR--ETEAALSREQQRSSQEQGELQGRLAERESQEQGLR-----QRLLDEQ 620
             +  A Q   R  E EA ++RE+Q   +E   L+  +A R+  E  LR     Q  L++Q
Sbjct: 764  EEKSALQGRQRQAEQEATVAREEQERLEEL-RLEQEVA-RQGLEGSLRVAEQAQEALEQQ 821

Query: 621  FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLT 680
               LR   ++    LQ+ +++L   L    +     L    +EA   V  LE   A+   
Sbjct: 822  LPTLRHERSQ----LQEQLAQLSRQL----SGREQELEQARREAQRQVEALERA-AREKE 872

Query: 681  SLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR-----ECGARALEL 735
            +LA   A +A     +     T+        L        L +  R     E     LE 
Sbjct: 873  ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932

Query: 736  MGQ--LQDQQALRHMQASLVRTPL--QGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
             GQ  L  ++ L    A L +  +  Q    L +EL  + L   + E  A + ++ AA  
Sbjct: 933  EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH- 991

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL----LVTTSTSLQKE 847
               E+ ++R++     A       + ++  ++     +L+  +      L     +LQ+E
Sbjct: 992  ---EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048

Query: 848  IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWG---ATQLVEAADKVVLHTGKYEELI 904
              + G   A  ++  A + + +E    + K +G     AT  +E   +      + E+  
Sbjct: 1049 -RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107

Query: 905  VCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIE-DR 963
               + + +    L A  +  A  H+  + RLQE +R + ++  + +   +  + Q+    
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167

Query: 964  DTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
            D  D        L+++ +E Q ++ E ++  E +R   GELR+
Sbjct: 1168 DARD-------GLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 181/788 (22%), Positives = 296/788 (37%), Gaps = 161/788 (20%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
            K D   + E  +  V  L SEL  ++ + +   A    +V  L+ +  +  KQ+   L +
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155

Query: 409  NEQLRHELAQLRAAQ-------LEGERSQGLREEAERK-----------------ASATE 444
             E+LR +L  L  A+       LE +R   LRE  E +                 A   E
Sbjct: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--LRESQEGREVQRQEAGELRRSLGEGAKERE 1213

Query: 445  ARYNKLKEKHSELVHVHAE---LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
            A     +E  S +    +E   L   N D  ++L + ++++  V +   +L   +++V+R
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273

Query: 502  ---ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 558
               E+  +L+E   Q++ L  E      ELA  Q  L+  E+++ E  SR +TL   +  
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE--SRRETLGLRQRL 1331

Query: 559  LSGAV-----------------------RQREADLLAAQSLVRETE-------AALSREQ 588
            L G                         R RE  LL +    R TE         L  + 
Sbjct: 1332 LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKL 1391

Query: 589  QRSSQEQGELQGRLAERESQEQGL---------RQRLLDEQFAVLRGAAAEAAGI----- 634
            + +  E  EL  RL+  E + QGL         ++R  + Q   LR A     G+     
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451

Query: 635  ----------LQDAVSK-----LDDPLHLRCT-----SSPDYLVSRAQEALDAVSTLEEG 674
                       +DA ++     L+ P  L C+      SP    S A   LD    +   
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGA 1510

Query: 675  HAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 727
              ++L  L  A           +AL R   LA        ATS       A +L     E
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSR------ARQLQKAVAE 1562

Query: 728  CGARALELMGQLQDQQA-LRHMQASLVRTPLQGILQLGQ-ELKPKSLDVRQEELGAVVDK 785
                   + G+L   QA L   + S+ R+  +    L Q     +SL   + EL A  +K
Sbjct: 1563 SEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK 1622

Query: 786  --EMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILN--------SCTDLMKAIR 835
              +M A    +E   RR++++++ +   S  VKLE+  R L           +D     +
Sbjct: 1623 ISKMKANETKLEGDKRRLKEVLDASE--SRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680

Query: 836  LLVTTSTSLQKEIVESGRGAATQQEFYAK------NSRWTEGLI-----SASKAVGWGAT 884
             L     SLQ+++ +S   A T Q    +          +EG +       ++A+   + 
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740

Query: 885  QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV--KANKHSPHLSRLQECSRTV 942
             L    DK  LH  K   L  C H+      +L AA +   +A K S   S L E  +T+
Sbjct: 1741 SLNSTRDK-NLHLQK--ALTACEHDRQVLQERLDAARQALSEARKQS---SSLGEQVQTL 1794

Query: 943  NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM--- 999
                A++       + Q++           L ++ +Q  E +   L   + L+ ER    
Sbjct: 1795 RGEVADLELQRVEAEGQLQ----------QLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844

Query: 1000 -RLGELRK 1006
             RLG L++
Sbjct: 1845 ERLGSLQR 1852



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 137/563 (24%), Positives = 220/563 (39%), Gaps = 82/563 (14%)

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
            LR  L +LR+AQ E       R+E   + SA   +  +++ +         +L +  A++
Sbjct: 1511 LREFLQELRSAQRE-------RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563

Query: 472  AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
             +     +     ++ V+ +LA Q E V+R SE +     DQ+  L+R L+A   EL  +
Sbjct: 1564 EE---ARRSVDGRLSGVQAELALQEESVRR-SERERRATLDQVATLERSLQATESELRAS 1619

Query: 532  QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 591
            QE +S               + A +  L G  R+ +  L A++S        +  E QR 
Sbjct: 1620 QEKIS--------------KMKANETKLEGDKRRLKEVLDASES------RTVKLELQRR 1659

Query: 592  SQEQGELQGR---LAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 648
            S E GELQ     L++RE+Q Q L+ R+   Q  V    +   AG LQ  V +L+  L  
Sbjct: 1660 SLE-GELQRSRLGLSDREAQAQALQDRVDSLQRQV--ADSEVKAGTLQLTVERLNGAL-- 1714

Query: 649  RCTSSPDYLVSRAQEAL-DAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGG 707
                     V  ++ AL D V  L E  AQ   SL          TR  +L     +   
Sbjct: 1715 -------AKVEESEGALRDKVRGLTEALAQSSASLNS--------TRDKNLHLQKALT-- 1757

Query: 708  ATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQA--SLVRTPLQGILQLG 764
            A  H          +D  R+  + A +    L +Q Q LR   A   L R   +G LQ  
Sbjct: 1758 ACEH--DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815

Query: 765  QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
            +E+    L  RQE   A ++     T   ++D  R +++ +   + A + ++ E  E + 
Sbjct: 1816 REV----LRQRQEGEAAALN-----TVQKLQDERRLLQERLGSLQRALAQLEAEKRE-VE 1865

Query: 825  NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
             S   L K    L  T   +++E + S           A+  R    L  A   +     
Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTV---RLSAEKGRLDRTLTGAELELAEAQR 1922

Query: 885  QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVK----ANKHSPHLSRLQECSR 940
            Q+ +   +VV+    +        E+ A   QL    +V+    A   +      +E + 
Sbjct: 1923 QIQQLEAQVVVLEQSHSP---AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH 1979

Query: 941  TVNERAANVVASTKSGQEQIEDR 963
                R      ST  GQ Q E R
Sbjct: 1980 RQRVRGLEEQVSTLKGQLQQELR 2002



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 87/412 (21%), Positives = 162/412 (39%), Gaps = 52/412 (12%)

Query: 384 LKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQ---LRAAQLEGERSQGLREEAERKA 440
           L+ +++ +E  L + R ++ +  +    +   L Q   L   +LE +  +GL  ++    
Sbjct: 86  LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQS---- 141

Query: 441 SATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK 500
                            V +  +L  + A   ++L   Q+ Q+  A++ ++L  ++ Q K
Sbjct: 142 -----------------VELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184

Query: 501 R---ESELKLEEKSDQLEKLK-------RELEAKAGELARAQEALSHTEQSKSELSSRLD 550
           +   E E +L E+S +LE+ +       ++LE+    L   Q+  +   Q  + L  +LD
Sbjct: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLD 244

Query: 551 TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
              +   ALS  +R+   D    +  +   EAA  RE++  +        RL     Q  
Sbjct: 245 QAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVV 304

Query: 611 GLRQRLLDE-------QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-- 661
           G R RL+ E           L G  A  +  +Q+A   L   L L  + +   L  +A  
Sbjct: 305 GFR-RLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL 363

Query: 662 -----QEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTD 716
                ++  D V   ++   Q + S  D + L A +T    LA   +            D
Sbjct: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG-LAVKRLEKQNLEKDQVNKD 422

Query: 717 PADRL--IDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQE 766
             ++L  +++ R     ALE       QQ LR +  +++     G+   G E
Sbjct: 423 LTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 70/286 (24%), Positives = 137/286 (47%), Gaps = 27/286 (9%)

Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ--LRH 414
           E  +R+ ++++    KI L+ ++  ++L+ Q+    GELE+QR +  +   D E   +R 
Sbjct: 164 EGQQRQAQLVQRLQGKI-LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL 222

Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAEL-LRKNADTAK 473
           E  Q R+A L  + +  LRE+ ++  SA +A    +++  ++      EL  R+ A   +
Sbjct: 223 EEEQQRSASL-AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281

Query: 474 QLTVTQQSQEEVARV----KEQLAFQ--VEQVKRESELKLEEKSDQLEKLKRELEAKAGE 527
           + +       E +R+    ++ + F+  V +VK  +E  L +   +L +  R ++     
Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341

Query: 528 L--------ARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREADLLAAQSLVR 578
           L        +RA+ AL      +++L  +L D +  EKD    A +Q ++DL  A    R
Sbjct: 342 LSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDL---AQQQMQSDLDKADLSAR 398

Query: 579 ETEAALS-REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            TE  L+ +  ++ + E+ ++   L E+    + LR   L EQ A+
Sbjct: 399 VTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR---LQEQAAL 441



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 86/277 (31%)

Query: 376  EAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREE 435
            EA++  + L  QV  L GE+ +   Q+ +A    +QLR  L Q              R+E
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ--------------RQE 1824

Query: 436  AERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQ 495
             E                                  A  L   Q+ Q+E   ++E+L   
Sbjct: 1825 GE----------------------------------AAALNTVQKLQDERRLLQERLG-- 1848

Query: 496  VEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHT--EQSKSELSSRLDT-- 551
                       L+    QLE  KRE+E  A  L + + AL  T  +  + +L S  DT  
Sbjct: 1849 ----------SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898

Query: 552  LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---------QEQGELQGRL 602
            LSAEK  L   +   E +L  AQ  +++ EA +   +Q  S         Q+Q ELQ  +
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958

Query: 603  ---------AER--ESQEQGLRQRL--LDEQFAVLRG 626
                      ER  E++E+  RQR+  L+EQ + L+G
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 45/182 (24%), Positives = 77/182 (42%), Gaps = 28/182 (15%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            Q+E+ KREVE     LEK ++  +R + +++ +   L    +  R   +K  +D      
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVERE--KLRSHEDTVRLSAEKGRLDR----- 1908

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                L  A+LE         EA+R+    EA+   L++ HS      A+L     D  +Q
Sbjct: 1909 ---TLTGAELE-------LAEAQRQIQQLEAQVVVLEQSHSP-----AQL---EVDAQQQ 1950

Query: 475  LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEA 534
                QQ  E +   + Q    +E  +R    ++    +Q+  LK +L+    EL R+   
Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ---ELRRSSAP 2007

Query: 535  LS 536
             S
Sbjct: 2008 FS 2009



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 71/304 (23%), Positives = 134/304 (44%), Gaps = 37/304 (12%)

Query: 731  RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQ----------EELG 780
            +++EL  QLQ++QA    +    +   Q   QL Q L+ K L  ++          E  G
Sbjct: 140  QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199

Query: 781  AVVDKEMAAT--SAAIEDAVRRIEDMMNQARHAS----SGVKLEVNERILNSCTDLMKAI 834
             +  + +  T  S  +E A+ R+E+   Q R AS    + +  E  ++  ++   L + I
Sbjct: 200  ELEQQRLRDTEHSQDLESALIRLEE--EQQRSASLAQVNAMLREQLDQAGSANQALSEDI 257

Query: 835  RLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEG----LISASKAVGWG--ATQLVE 888
            R +    T  +KE+    R AA ++E  + N+ ++      L+   + VG+    +++  
Sbjct: 258  RKVTNDWTRCRKEL--EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315

Query: 889  AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 948
              ++ +L  G   EL   S  +  +   L    ++  ++    L +       + E+  +
Sbjct: 316  FTERDLLQLG--GELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD 373

Query: 949  VVASTKS-GQEQIE-DRDTMDFS------GLSLIKLKKQEMETQVRVLELEKTLEA-ERM 999
             V   K   Q+Q++ D D  D S      GL++ +L+KQ +E      +L + LEA E +
Sbjct: 374  KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433

Query: 1000 RLGE 1003
            RL E
Sbjct: 434  RLQE 437


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 167/715 (23%), Positives = 304/715 (42%), Gaps = 103/715 (14%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
            K + +++++  + E+E ++++ E+ + +A+  + Q++ +       L E   Q QK L D
Sbjct: 884  KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943

Query: 409  NEQLRHELAQ-LRAAQLEGERSQGLRE----EAERKASATEARYNK----LKEKHSELVH 459
              Q    L Q ++  +L+ + + G+ +    EA+R+      ++      L+E+ S L+ 
Sbjct: 944  ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003

Query: 460  VHAELLRKNADTAKQLTVTQQSQEEVAR-VKEQLAFQVEQVKRESELKLEEKS---DQLE 515
               +L ++  D   QL     SQ  V + V+E+L    E  + + EL+ E+ S     +E
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063

Query: 516  KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 575
            K +R L  +  +  R QE LS   Q   E       LSA+ + L   V+++EAD LA ++
Sbjct: 1064 KEQRLLVLQEADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122

Query: 576  -LVRETEAALSREQQRSSQ------EQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
             L+ E EA+   EQQ  +       +  +LQ RL   ESQ + L     ++Q     G  
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL---AAEQQ----PGNQ 1175

Query: 629  AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 688
            A+A   L    S L   L   C S P+  +S   ++  +V  LE        SL     L
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPE--LSGGGDSAPSVWGLEPDQ-NGARSLFKRGPL 1232

Query: 689  VAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHM 748
            + A      L+A+ + +     H        +  D  R+   +  +L  +L D +A    
Sbjct: 1233 LTA------LSAEAVASALHKLH-QDLWKTQQTRDVLRD---QVQKLEERLTDTEA---- 1278

Query: 749  QASLVRTPLQGI-LQLGQELKPKS-LDVRQEELGAVVDKEMAATSAAIEDAVRRI----- 801
            + S V T LQ +  QL Q  + KS  + +Q  L + +  E+  T A+++  +RR      
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL-MELHETMASLQSRLRRAELQRM 1337

Query: 802  -------------EDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                         E++  Q  H  + V   V  R   S   +++       ++  L+ E 
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAV---VEARAQASAAGILEEDLRTARSALKLKNEE 1394

Query: 849  VES--GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVC 906
            VES   R  A Q++   K ++      +  + +      L E  ++V    G+ +EL   
Sbjct: 1395 VESERERAQALQEQGELKVAQGK----ALQENLALLTQTLAEREEEVETLRGQIQEL-EK 1449

Query: 907  SHEIAASTAQLVAASKVKANK----HSPHLSRLQEC-------SRTVNERAANVVASTKS 955
              E+  +  +L++    K N+        +  L++C          V ER   +    + 
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 956  GQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK---TLEAERMRLGELRKQ 1007
             +E  +DR+T             Q    + ++LELEK    +E++R ++ +L+KQ
Sbjct: 1510 IRELEKDRET-------------QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 116/537 (21%), Positives = 226/537 (42%), Gaps = 88/537 (16%)

Query: 351  DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN- 409
            +RD +++S + ++E L+ + E +  + +R   +L  Q   ++  LE+QR ++ K L ++ 
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ-VLEDQRTRQTKILEEDL 1685

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKL---------KEKHSELVHV 460
            EQ++  L + R  +L  +R Q ++E AE     ++A+   L         KEK  E    
Sbjct: 1686 EQIKLSLRE-RGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE 1743

Query: 461  HAELLRKNADTAKQ-------------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
            H   L++  D  +Q             L ++Q+ QE V      L  Q+++ + + ELK 
Sbjct: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV-----LQQQLQEAREQGELKE 1798

Query: 508  EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQRE 567
            +    QL++ +R L  +  EL   Q+     +  +  +  + D L    +     +++R 
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 568  ADLLAAQSLVRETEAALS---REQQRSSQEQGELQGRLAERESQEQGLRQRLLDE----- 619
             +L   +   R  E  L+   R  Q   +  G+L+    E+E     L+Q+  ++     
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 620  -QFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-----QEALDAVSTLEE 673
             +   L+ +  +A  +L++   +L+       +S      +RA     QEAL       +
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978

Query: 674  GHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
            G  Q+L   A+ S  + A T     + D        +H    + A R+ +          
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLD-----ACQAHSRQLEEALRIQE---------- 2023

Query: 734  ELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAA 793
               G++QDQ  LR+ +   V+   Q + Q  +EL+       Q+E   +++K +A     
Sbjct: 2024 ---GEIQDQD-LRYQED--VQQLQQALAQRDEELR------HQQEREQLLEKSLA----- 2066

Query: 794  IEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVE 850
                 +R+++ M Q +           ER       L +++R L  T    ++EI+E
Sbjct: 2067 -----QRVQENMIQEKQNLG------QEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 156/736 (21%), Positives = 307/736 (41%), Gaps = 74/736 (10%)

Query: 312  DEEPENLIEISTGPPAGEPVVVADLFD-QTFGPPNGSVKDDRDLQIESLKREVEMLRSEL 370
            + + ++L E   G  + + ++ + LF+ Q         K   ++QI+++ +  E+++ E+
Sbjct: 749  ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808

Query: 371  EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH--ELAQLRAAQLEGER 428
              +KLE     +Q + + +A   +L  Q +Q+ K  ++ ++  H  E+ QLR  + E ER
Sbjct: 809  RCLKLELDTERSQAEQERDAAARQL-AQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKER 866

Query: 429  SQGLREEAERKASATEARYN---KLKEKHSELVHVHAE-----------LLRKNADTAKQ 474
            S   +E A+   S    +     +LKE+ +E+  + A+           L +   +T K+
Sbjct: 867  SWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926

Query: 475  ----LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS----DQLEKLKRELEAKA- 525
                L    Q+Q+E+A   +QL  ++ Q  +  +LK +E +     QL++ +REL+  A 
Sbjct: 927  RVSLLETLLQTQKELADASQQLE-RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 526  ---GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
                +LA  QE  S   Q K +L  +++ L ++  A   + R  E ++   Q  +RET+ 
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV---QEKLRETQ- 1041

Query: 583  ALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVS 640
              +R Q+   +E+  L   L E+E +   L++   +  ++ + LR    EA G  ++  +
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101

Query: 641  KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAA 700
            +++           D+L   AQ        LEE  A ++T       L A+L      AA
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQ-------LLEELEASHITE----QQLRASLWAQEAKAA 1150

Query: 701  DTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGI 760
               +   +T        A++      +  A+   L   L  QQAL  +  S  R  L G 
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL--QQALGSVCES--RPELSG- 1205

Query: 761  LQLGQELKPKSLDVRQEELGA-VVDKE----MAATSAAIEDAVRRIEDMM---NQARHAS 812
               G +  P    +  ++ GA  + K      A ++ A+  A+ ++   +    Q R   
Sbjct: 1206 ---GGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262

Query: 813  SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
                 ++ ER+ ++  +  +    L      L +   E  +    Q    ++     E +
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 873  ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
             S    +     Q +EA  +         EL+  + E   +  + + A+ V+A   +   
Sbjct: 1323 ASLQSRLRRAELQRMEAQGE--------RELLQAAKENLTAQVEHLQAAVVEARAQASAA 1374

Query: 933  SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVL-ELE 991
              L+E  RT            +S +E+ +         ++  K  ++ +    + L E E
Sbjct: 1375 GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434

Query: 992  KTLEAERMRLGELRKQ 1007
            + +E  R ++ EL KQ
Sbjct: 1435 EEVETLRGQIQELEKQ 1450



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 75/333 (22%), Positives = 150/333 (45%), Gaps = 39/333 (11%)

Query: 350  DDRDLQIESLKREVEMLRSEL---EKIKLEAQRYIAQLKSQ---VNALEGELEEQRKQKQ 403
            + +D  IES + +V+ L+ +L   E + LE +    +++ Q   +  LEG+ E QR    
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 404  KALVDNEQLRHELAQLRAAQLEGERSQG--LREEAERKASATEARYNKLKEKHSELVHVH 461
               +D E+   EL Q +++Q+    S    L  E + +    +++  +++E   +  H+ 
Sbjct: 1592 HLTLDLEERSQEL-QAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650

Query: 462  AELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK-----RESELK-----LEEKS 511
             +L R++ +   Q    Q  +++  R  + L   +EQ+K     R  EL      ++E++
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 512  DQ-----------LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS 560
            ++           LE +K  L  K  E+   QE +   ++ K +L  +L  L  +    S
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 561  GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ------ 614
              + QRE +++  Q  ++E       ++Q    +  E Q  LA+R+ + + L+Q      
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830

Query: 615  ---RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
                 + E+   L+GA  +A   L++   +L D
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQD 1863



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 78/353 (22%), Positives = 152/353 (43%), Gaps = 46/353 (13%)

Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQV---NALEGELEEQRKQKQKALVDNEQLR 413
           E+L  +   L  +L +++ E Q   +++++     NAL+ +L E  K+++     N  L 
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665

Query: 414 HEL--AQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
            +L  A+   A+L+ +      E+ E +   +E+R+ + +   ++L  +H E  R+    
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ-EAATTQLEQLHQEAKRQEEVL 724

Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
           A+ +    Q +E + R K  L  +++ V+R+ +    + ++QL+ L    E     L  A
Sbjct: 725 ARAV----QEKEALVREKAALEVRLQAVERDRQ----DLAEQLQGLSSAKELLESSLFEA 776

Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-------------QREADLLAAQSLVR 578
           Q+  S  E +K +L  ++ T++  K+ + G VR             ++E D  A Q    
Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836

Query: 579 ETEAALSREQQRSSQE-----------------QGELQGRLAERESQEQGLRQRLLDEQ- 620
           E E   + EQQ+++ E                 Q EL   L   E ++  L  RL ++Q 
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896

Query: 621 -FAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLE 672
               ++    E     + A+ ++         S  + L+   +E  DA   LE
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 137/711 (19%), Positives = 301/711 (42%), Gaps = 78/711 (10%)

Query: 344  PNGSVKDD--RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQ 401
            PNGS + D     Q+  L  + +    ELEK   E  + + QLKSQ +  + EL+++  +
Sbjct: 232  PNGSGRMDGREPAQLLLLLAKTQ----ELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287

Query: 402  KQKALVDNEQLRHELAQLRAAQ------LEGERSQGLREEAERKASATEARYNKLKEKHS 455
                L  +++   +  ++  A       LE   ++ +  EA    +A E + + L++   
Sbjct: 288  LSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIK 346

Query: 456  ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 515
            ++  V  E      D   Q +  + S E  + +  Q  +Q      +++  L      L 
Sbjct: 347  DITQVMVE----EGDNIAQGSGHENSLELDSSIFSQFDYQ------DADKALTLVRSVLT 396

Query: 516  KLKRELEAKAGELARAQEALSHTEQSKSE-------LSSRLDTLSAEKDALSGAV--RQR 566
            + ++ ++    +LA  QEA++  +Q   +       L  RL  L+ E+D L+G     Q 
Sbjct: 397  RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456

Query: 567  EADLLAAQ-SLVRETEAALSREQQRSSQE---------QGELQGRLAERESQEQ------ 610
            E D L+ +  L+++    L ++ +   QE         + +LQG  A+ + +EQ      
Sbjct: 457  EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516

Query: 611  GLRQR-LLDEQFAVLRGAAAEAAG---ILQDAV--SKLDDPLHLRCTSSPDYLVSRAQEA 664
             +R+R  L E    L    +E+      L++A+  S L+  L  +  +     ++RA+++
Sbjct: 517  AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576

Query: 665  LDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
            +  +S+ E      +  L  A+  ++AL     LA D +   G    L   +  ++ + +
Sbjct: 577  IAELSSSENTLKTEVADLRAAAVKLSALN--EALALDKV---GLNQQLLQLEEENQSVCS 631

Query: 725  CRECGARALELMGQLQDQQALRHMQA-----SLVRTPLQGILQLGQELKPKSLDVRQEEL 779
              E   +A   + Q+   +A +  +A     + +   LQ   + G EL+    D+++E+ 
Sbjct: 632  RMEAAEQARNAL-QVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK- 689

Query: 780  GAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVT 839
               + K+++ +    E A  ++E +  +A+     +   V E+   +      A+ + + 
Sbjct: 690  -EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK--EALVREKAALEVRLQ 746

Query: 840  TSTSLQKEIVESGRGAATQQEFYAKN---SRWTEGLISASKAVGWGATQLVEAADKVVLH 896
                 ++++ E  +G ++ +E    +   ++    +I  +K       Q V  A +V+  
Sbjct: 747  AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806

Query: 897  TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSG 956
              +  +L + +    A   +  AA ++   +     +  Q+  +  +E+  N +      
Sbjct: 807  EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ--KAAHEKEVNQLREKWEK 864

Query: 957  QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
            +     ++       +L  L++++ME ++R+ E +  +EA + +  E R Q
Sbjct: 865  ERSWHQQEL----AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 87/371 (23%), Positives = 143/371 (38%), Gaps = 110/371 (29%)

Query: 348  VKDDRDLQIESLKREV---EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 404
            +KD  + Q++ L R+V    +L S+ E+  +  Q+ + + + Q    E  L+ Q  + Q+
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810

Query: 405  ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT----EARYNKLKEKHSELV-- 458
            AL   +Q      +L A Q E +++QG  E  + KA A     E  +  LKE+H EL   
Sbjct: 1811 ALAQRDQ------ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864

Query: 459  ----------------------HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQV 496
                                   V  +L  ++ +  K L   QQ   E A+  E     +
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924

Query: 497  EQVKRESELKLEEKSDQLEKLKRE--------------LEAKAGELARAQEALSHTEQ-- 540
            +    +++  L+E+  +LE L+ E               EA    L +A  AL   EQ  
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984

Query: 541  -SKSELSSRLD----TLSAEKDA--------------------------------LSGAV 563
              ++ELS  L+    TL A  DA                                L  A+
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044

Query: 564  RQREADL--------LAAQSLVRETEAALSREQQRSSQEQ------------GELQGRLA 603
             QR+ +L        L  +SL +  +  + +E+Q   QE+             ELQ  LA
Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104

Query: 604  ERESQEQGLRQ 614
            ++E +   LR+
Sbjct: 2105 QKEQEILELRE 2115



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 77/338 (22%), Positives = 130/338 (38%), Gaps = 54/338 (15%)

Query: 342  GPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ-----LKSQVNALEGELE 396
            G  N    +  +L       +  + R+EL++++ + +R + Q     L +QV  L+  + 
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365

Query: 397  EQRKQKQKALVDNEQLRHELAQLRA----AQLEGERSQGLREEAERKASATEARYNKLK- 451
            E R Q   A +  E LR   + L+      + E ER+Q L+E+ E K +  +A    L  
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL 1425

Query: 452  ----------------------EKHSELVHVHAELLRKNADTAKQLTVTQQSQ----EEV 485
                                  EK  E+     ELL  +     Q    QQ Q    E+ 
Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485

Query: 486  ARVKEQLAFQVEQ------VKRESELKLEEKSD-----------QLEKLKRELEAKAGEL 528
              V E L   V++      V+RE   +LE+  +           +LEK  + +E++ G++
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545

Query: 529  ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
               ++ L   E    EL      +  ++  +     QRE   +A   L  + E      Q
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605

Query: 589  QRSSQ-EQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
             +SSQ    E    +  RE QE+    +   EQ   L+
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 18/199 (9%)

Query: 351  DRDLQIESLKREVEMLRSELEKIKLEA--QRYIAQLKS---------QVNALEGELEEQR 399
            +RD + + L+ E+E+ R  LEK +L +      A+L S         +V+ +E E     
Sbjct: 2203 ERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262

Query: 400  KQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVH 459
             +KQ     + + R E  Q   A+LE +RS+  R   + +++  +    + K K   +  
Sbjct: 2263 MEKQ-----SWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317

Query: 460  VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKR 519
              A  L  +  TA   T      ++ +  K     Q E V  +++L LE K  Q + + R
Sbjct: 2318 AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ-DYITR 2376

Query: 520  ELEAKAGELARAQEALSHT 538
              +  + ELA    +LSH+
Sbjct: 2377 SAQT-SRELAGLHHSLSHS 2394


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 163/797 (20%), Positives = 320/797 (40%), Gaps = 102/797 (12%)

Query: 309  APEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRS 368
            A E+E+ +NL +I       + V+++DL             ++R  + E  ++E+E  + 
Sbjct: 1016 AEEEEKAKNLAKIRNK----QEVMISDL-------------EERLKKEEKTRQELEKAKR 1058

Query: 369  ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV--DNEQLRHELAQLRAAQLEG 426
            +L+    + Q  IA+L++Q++ L+ +L ++ ++ Q AL   D+E L    A     +L+ 
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118

Query: 427  ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVA 486
            + ++   +    KAS  +A   K ++   EL  +  EL      TA Q  +  + ++EVA
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177

Query: 487  RVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------------------- 519
             +K+ L         Q++ +++     LEE S+QLE+ KR                    
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237

Query: 520  -----------ELEAKAGEL-ARAQE---ALSHTEQSKSELSSRLDTLSAEKDALSGAVR 564
                       E E K  +L A+ QE    +S  ++ + EL+ +   L  E D +S  + 
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297

Query: 565  QRE-------ADLLAAQSLVRETEAALSREQQRS------SQEQGELQGRLAERESQEQG 611
            + E        D  + +S +++T+  L  E ++        ++  E +  L E++ +E+ 
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357

Query: 612  LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPDYLVSRAQEALDAVS 669
             R+  L++Q   L+   A+    + D +  ++  +    +     + L  R +E   A  
Sbjct: 1358 ARKN-LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416

Query: 670  TLE------EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLID 723
             LE      +     LT   D    VA+         D ++    +      +  DR   
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476

Query: 724  TCRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQEL--KPKSLDVRQEE 778
              RE   +AL L   L++    +     Q   +R  ++ ++    ++      L+  +  
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536

Query: 779  LGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLV 838
            L   V+ EM      +ED ++  ED   +       +K +    +        +  RLL+
Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 839  TTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTG 898
                 L+ E+ +  +  A       K     + L +  +A      ++++   K+     
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 899  KYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQ-ECSRTVNERAANVVASTKSGQ 957
             Y+  +    E  AS  ++ A SK    K    L  L+ E  +   E A++  A   + Q
Sbjct: 1656 DYQREL---EEARASRDEIFAQSKESEKK----LKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 958  E--QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGAS 1015
            E  ++ D  T   SG S +  +K+ +E   R+ +LE+ LE E+  +  L  +        
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLE--ARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766

Query: 1016 GSPGEEVAIRPSTAPRS 1032
             +   E+A   S A +S
Sbjct: 1767 DTLNAELAAERSAAQKS 1783



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 118/515 (22%), Positives = 213/515 (41%), Gaps = 72/515 (13%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHE 415
            ++  + E E  R  LEK  L  Q  +A  K +V+   G +E   + K+K L D E L   
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407

Query: 416  LAQLRAAQLEGERSQG-LREEAE----------RKASATEARYNK----LKEKHSELVHV 460
            L +   A  + E+++  L++E +          + AS  E +  K    L E+ S     
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 461  HAELLRKNADTAKQLTVT---QQSQEEVARVKEQLAFQVEQVKRESELKLEEKSD----- 512
              E  R  A+  ++ T      ++ EE    KE+   Q +Q++ + E  +  K D     
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527

Query: 513  -QLEKLKRELEAKAGE----LARAQEALSHTEQSKSELSSRLDTLSA--EKDALSGAVRQ 565
             +LEK KR LE +  E    L   ++ L  TE +K  L   +  + A  E+D  +   + 
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587

Query: 566  READLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQEQGLRQRLLDEQFA 622
             E   L  +  VRE EA L  E+++ +     + +++  L + E+Q +    +  DE   
Sbjct: 1588 EEKKRLLIKQ-VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN-KARDEVIK 1645

Query: 623  VLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSL 682
             LR   A+    ++D   +L++       +S D + ++++E+   + +LE    Q    L
Sbjct: 1646 QLRKLQAQ----MKDYQRELEE-----ARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696

Query: 683  ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
            A +        +     AD I N  +            L+D  R   AR  +L  +L+++
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGK--------SALLDEKRRLEARIAQLEEELEEE 1748

Query: 743  QALRHMQASLVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVV 783
            Q+   +     R     +  L  EL                   + K L  + +EL   V
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQ-ARHASSGVKL 817
              +  AT +A+E  + ++E+ + Q A+  ++  KL
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 86/345 (24%), Positives = 153/345 (44%), Gaps = 34/345 (9%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +DR  +  S   E E     L KI+ + +  I+ L+ ++   E   +E  K K+K   + 
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
              L+ ++A+L+ AQ++  + Q  ++E E + +               L     E L KN 
Sbjct: 1065 TDLQDQIAELQ-AQIDELKLQLAKKEEELQGA---------------LARGDDETLHKN- 1107

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGEL 528
                 L V ++ Q ++A ++E   F+ E+  R ++E +  + S++LE LK ELE      
Sbjct: 1108 ---NALKVVRELQAQIAELQED--FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162

Query: 529  ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
            A  QE  +  EQ  +EL   L+  +   +A    +RQR A   A + L  + E A   + 
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA--TALEELSEQLEQAKRFKA 1220

Query: 589  QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHL 648
                 +QG       E +++E     ++L +  A       +    +Q+  +K+ +   L
Sbjct: 1221 NLEKNKQG------LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274

Query: 649  RCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSLADASALVAAL 692
            R   +     S+ Q  LD VST LEE   + +    DA++L + L
Sbjct: 1275 RVELAEK--ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 59/283 (20%), Positives = 132/283 (46%), Gaps = 15/283 (5%)

Query: 355  QIESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            Q++  +RE+E  R+  ++I     E+++ +  L++++  L+ EL    + ++ A  + ++
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712

Query: 412  LRHEL---AQLRAAQLEGERS-----QGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            L  E+   A  ++A L+ +R        L EE E + S  E   ++ ++   ++  ++AE
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
            L  + +   K     QQ + +   +K +L      VK + +  +     ++ +L+ +LE 
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832

Query: 524  KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
            +A E A A + +  TE+   E+  +++      D     + +  A +   + L R+ E A
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM---KQLKRQLEEA 1889

Query: 584  LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
               E  R++  + +LQ  L +     +GL + +   +  + RG
Sbjct: 1890 -EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 145/707 (20%), Positives = 287/707 (40%), Gaps = 95/707 (13%)

Query: 354  LQIES-LKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGE---LEEQRKQKQKALVD- 408
            LQ E+ L  E E +R+ L   K E +  +  L+S+V   E     L+ ++K+ Q  + D 
Sbjct: 896  LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955

Query: 409  NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK-LKEKH--SELVHVHAELL 465
             EQL  E    +  QLE   ++   ++ E +    E + +K +KEK    + +   +  L
Sbjct: 956  EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015

Query: 466  RKNADTAKQLTVTQQSQ-------EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLK 518
             +  + AK L   +  Q       EE  + +E+   ++E+ KR+ + +  +  DQ+ +L+
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075

Query: 519  RELEAKAGELARAQE------------------ALSHTEQSKSELSSRLDTLSAEKDALS 560
             +++    +LA+ +E                  AL    + +++++   +   +EK + +
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135

Query: 561  GAVRQR---EADLLAAQSLVRETEAALSREQQ---RSSQEQGELQGRLAE----RESQEQ 610
             A +Q+     +L A ++ + +T    + +Q+   +  QE  EL+  L E     E+Q Q
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195

Query: 611  GLRQR---LLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDA 667
             +RQR    L+E    L  A    A + ++      D   L C            + L  
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC----------EVKVLQQ 1245

Query: 668  VSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRE 727
            V    E   + L   A    L A ++    L  +  +   A+      D    L++   +
Sbjct: 1246 VKAESEHKRKKLD--AQVQELHAKVSEGDRLRVE--LAEKASKLQNELDNVSTLLEEAEK 1301

Query: 728  CGAR----ALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAV- 782
             G +    A  L  QLQD Q L   +          I QL +E    SL  +QEE     
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE--KNSLQEQQEEEEEAR 1359

Query: 783  --VDKEMAATSAAIEDAVRRIEDMMNQARHASSGVK--LEVNERILNSCTDLMKAIRLLV 838
              ++K++ A  + + D  ++++D +          K  L+  E +     +   A   L 
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419

Query: 839  TTSTSLQKEI------VESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADK 892
             T   LQ+E+      ++  R  A+  E   K  +  + L++  K++   + +  E  D+
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLE---KKQKKFDQLLAEEKSI---SARYAEERDR 1473

Query: 893  VVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVAS 952
                  + E   +    +A +  + + A +    ++    + +++   + ++   NV   
Sbjct: 1474 AEAEAREKETKAL---SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530

Query: 953  TKSG---QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEA 996
             KS    ++Q+E+  T       L +L+ +   T+   L LE  ++A
Sbjct: 1531 EKSKRALEQQVEEMRT------QLEELEDELQATEDAKLRLEVNMQA 1571



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 40/307 (13%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN---- 409
            LQ+   + E++    EL K+K +  +           +EGELEE  ++ Q+ L +     
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTK-----------VEGELEEMERKHQQLLEEKNILA 893

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            EQL+ E      A+    R    ++E E      E+R  + +E++  L +   ++     
Sbjct: 894  EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVK----RESELKLEEKSDQLEKLKRELEAKA 525
            D  +QL      +EE AR K QL     + K     E  L LE+++ +  K K+ +E + 
Sbjct: 954  DLEEQL-----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008

Query: 526  GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
             E    LA  +E   +  + +       S+L  RL      +  L  A R+ + +    Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 575  SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGI 634
              + E +A +   + + ++++ ELQG LA  + +       L      V+R   A+ A +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRELQAQIAEL 1123

Query: 635  LQDAVSK 641
             +D  S+
Sbjct: 1124 QEDFESE 1130


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 147/705 (20%), Positives = 278/705 (39%), Gaps = 80/705 (11%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALVDNEQ 411
            I  L+  +  L    E+++  +Q + A+L +QV +L  EL       ++Q Q+     +Q
Sbjct: 468  ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527

Query: 412  LRHELAQL-RAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNAD 470
             + + AQL +  Q + + SQGLR + E+ +S+       LK+K  +L  V  +      D
Sbjct: 528  AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS-------LKQKEQQLKEVAEKQEATRQD 580

Query: 471  TAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 530
             A+QL    + +E   R ++    Q+E +++E   KLE    QL+      ++       
Sbjct: 581  HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS------- 633

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 590
            AQ +++  ++ K+ELS +++ L A        V     +   AQ+ V E E  L  EQQ+
Sbjct: 634  AQTSVTQAQREKAELSRKVEELQA-------CVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 591  SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 650
            +++++     R+A+ + Q Q   Q  L E   V +G+  E      DA+ +       RC
Sbjct: 687  ATEKE-----RVAQEKDQLQEQLQ-ALKESLKVTKGSLEEEKRRAADALEE-----QQRC 735

Query: 651  TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA----LVAALTRF--SHLAADTII 704
             S          E      +L E H +    L +  A    L A L +   +H A   ++
Sbjct: 736  IS----------ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ-------ALRHMQASLVRTPL 757
                   +A    A+     C +          + +D Q       A+   Q   ++   
Sbjct: 786  RRELAEAMAAQHTAE---SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842

Query: 758  QGILQLGQELKPK--SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGV 815
            +   Q  QE K K   ++   E   +    E+A   A +  A++++++   +A+  +  +
Sbjct: 843  EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902

Query: 816  K------LEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESG-RGAATQQEFYAKNSRW 868
                      ++ +    T + KA     T S  L KE   +G R     +E   +    
Sbjct: 903  STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962

Query: 869  TEGLISASKAVGWGATQLVEAADKVVLHT--GKYEELIVCSHEIAASTAQLVAASKVKAN 926
            T+  + A +         +E     ++ +   + EE      E+A  T +   A    A 
Sbjct: 963  TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022

Query: 927  KHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVR 986
            + +            +NE+        ++    + +++  D     L KL+  E      
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD---QELAKLRGLEAAQIKE 1079

Query: 987  VLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPR 1031
            + EL +T++  + +L +  K+H   A  SG+  E       T P+
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEH---ASGSGAQSEAAGRTEPTGPK 1121



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 148/695 (21%), Positives = 273/695 (39%), Gaps = 57/695 (8%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            +D ++  LK++ +  +++L +   + ++    L+ QV  L   L+++ +Q ++     E 
Sbjct: 517  QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576

Query: 412  LRHELAQLRAAQLEGERSQGLREE--AERKASATEARYNKLKEKHSELVHVHAELLRKN- 468
             R + AQ  A   E ER   LRE   A ++  A E      KEK ++L  +  +L   N 
Sbjct: 577  TRQDHAQQLATAAE-EREASLRERDAALKQLEALE------KEKAAKLEILQQQLQVANE 629

Query: 469  ADTAKQLTVTQQSQE--EVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAG 526
            A  + Q +VTQ  +E  E++R  E+L   VE  ++E      E   Q+ +L+ +L ++  
Sbjct: 630  ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH----EAQAQVAELELQLRSEQQ 685

Query: 527  ELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSR 586
            +    +      +Q + +L +  ++L   K +L    R+    L   Q  + E +A    
Sbjct: 686  KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745

Query: 587  EQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
              ++  +E+ EL+   A R+  E  L+Q       +  VLR   AEA      A S+ + 
Sbjct: 746  LVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805

Query: 645  PLHLRCTSSPDYLVSRAQEAL------DAVSTLEEGHAQYLTSLADASALVAALTRFSHL 698
             +         Y  S+ +EA       + + TL+E   +    L +A   VA +   S L
Sbjct: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865

Query: 699  AADTIINGGATSHLAPTDPADRLIDTCRECGARALEL---MGQLQDQQALRHMQAS---- 751
                  N  A  H        R +   +E   RA +L   +  LQ++ A    + +    
Sbjct: 866  QISRQQNELAELHANLA----RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921

Query: 752  LVRTPLQGILQLGQEL--KPKSLDVRQEE-LGAVVDKEMAATSAAIEDAVRRIEDMMNQA 808
            LVR   +      +EL  +P     RQ E L     ++  +T AA++   R  E M N+ 
Sbjct: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981

Query: 809  RHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRW 868
                + +     ++         +  RL      +     +E    A  +       +  
Sbjct: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041

Query: 869  TEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKH 928
                 +  +A+    T+            GK +EL        A    L AA   +  + 
Sbjct: 1042 RVEFATLQEALAHALTE----------KEGKDQEL--------AKLRGLEAAQIKELEEL 1083

Query: 929  SPHLSRLQE-CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRV 987
               + +L+E  ++   E A+   A +++          ++     + KL++Q  + Q + 
Sbjct: 1084 RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQA 1143

Query: 988  LELEKTLEAERMRLGELRKQHYVLAGASGSPGEEV 1022
              LE++LEAER    E       L G      +E+
Sbjct: 1144 DSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 160/748 (21%), Positives = 289/748 (38%), Gaps = 150/748 (20%)

Query: 344 PNGSVKDDRDLQIESLKR----------EVEMLRSELEKIKLEAQRYIAQLKSQVNAL-- 391
           P G +      Q+  LK+          E+E+  +E  K+  E    IA ++ +++ L  
Sbjct: 204 PMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263

Query: 392 -----------EGELEEQR--------------KQKQKALVDNEQLRHELAQLRAAQLEG 426
                        ELEE R              KQ Q    +  Q+  ++ QL  ++  G
Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--SEENG 321

Query: 427 ERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQS----- 481
           + S  LRE A       +A  N+L E+HS+      E L K A   K+L+   Q      
Sbjct: 322 DLSFKLREFASHLQQLQDA-LNELTEEHSKATQ---EWLEKQAQLEKELSAALQDKKCLE 377

Query: 482 ------QEEVARVKEQLA-----------------FQVEQVKRES--------------- 503
                 Q ++++++E L+                  Q+E +K+E+               
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437

Query: 504 ---------ELKL-------EEKSDQLEKLKRELEAKAGELARAQEALSHTEQSK-SELS 546
                    E KL       EE+  QL  L  +L++    L++A+E L    Q+  + L+
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497

Query: 547 SRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-QQRSSQEQG------ELQ 599
           +++ +L++E   L+  ++Q++ +L   +   +E +A L++  QQ+    QG      +L 
Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557

Query: 600 GRLAERESQ--EQGLRQRLLDEQFAVLRGAAA---EAAGILQDAVSKLDDPLHLRCTSSP 654
             L ++E Q  E   +Q    +  A     AA   EA+   +DA  K  + L     +  
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617

Query: 655 DYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAP 714
           + L  + Q A +A  + +       TS+  A    A L+R        +       H A 
Sbjct: 618 EILQQQLQVANEARDSAQ-------TSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670

Query: 715 TDPAD-RLIDTCRECGARALELMGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKS 771
              A+  L     +  A   E + Q +D  Q+ L+ ++ SL  T  +G L   +E K ++
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT--KGSL---EEEKRRA 725

Query: 772 LDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEV----------NE 821
            D  +E+   +   E+ A + ++ +  +R    + + R    G++  +           E
Sbjct: 726 ADALEEQQRCI--SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783

Query: 822 RILNSCTDLMKAIRLLVTTSTSLQKEIVE-SGRGAATQQEFYAKNSRWTEGLISASKAVG 880
            +     + M A     +    L KE+     R   +QQE     + + E L++  +   
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843

Query: 881 WGATQLVEAADKVV-------LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLS 933
               +L EA +KV        L   + +  +   H   A   Q V   +V+A K +  LS
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903

Query: 934 RLQECSRTVNERAANVVASTKSGQEQIE 961
            LQE     ++  A +    +   EQ E
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQE 931



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 157/723 (21%), Positives = 282/723 (39%), Gaps = 99/723 (13%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD------- 408
            +++++RE E + +ELE+++        Q + +    E E+    +++ +A  D       
Sbjct: 967  LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026

Query: 409  ------------NEQ----------LRHELAQLRAAQLEGERSQGLREEAERKASATEAR 446
                        NEQ          L H L +      E  + +GL     ++       
Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQT 1086

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQE----EVARVKEQLAFQVEQVKR- 501
              +LKE+ ++    HA      ++ A +   T    E    EV+++++Q   Q EQ    
Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146

Query: 502  ESELKLE-----EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEK 556
            E  L+ E     E+   LE L+ +LE KA EL  +Q AL+  ++  +   +++   S  +
Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206

Query: 557  DALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR----LAERE-SQEQG 611
            D     V +   +     SL+   E  +S   ++  +++GE +      +AE E SQ+  
Sbjct: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266

Query: 612  LRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY---LVSRAQEALDAV 668
             R RLL  + A     AAE +  L++ V  L +    +  +S +    L S+A+ A +  
Sbjct: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326

Query: 669  STLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCREC 728
              L+    ++       S L    T    L ++ +       HL     A++     R  
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL----PAKHLCQQLQAEQAAAEKRH- 1381

Query: 729  GARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
                LE     Q +QA   ++A L+R       +LG EL P    V ++E  A   +   
Sbjct: 1382 -REELE-----QSKQAAGGLRAELLRAQ----RELG-ELIPLRQKVAEQERTAQQLRAEK 1430

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--KAIRLLVTTSTSLQK 846
            A+ A     +++   ++ +  +   G +  +  + L    D    K ++ L       + 
Sbjct: 1431 ASYAEQLSMLKKAHGLLAE-ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489

Query: 847  EIVESGRGA-ATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIV 905
             + E  R A +T +E     +++ EG   A   V     +  E   K+   T + E+L V
Sbjct: 1490 RLAEVQREAQSTARELEVMTAKY-EG---AKVKVLEERQRFQEERQKL---TAQVEQLEV 1542

Query: 906  CS-------HEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQE 958
                      E++   A    ASKV+  K    L  +Q       + A  + A     Q 
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQK----LKAVQAQGGESQQEAQRLQAQLNELQA 1598

Query: 959  QIEDRD-TMDFSGLSLIKLK---------KQEMETQVRVLEL----EKTLEAERMRLGEL 1004
            Q+  ++   +   L + K K          QE++ Q+R LE      K L AE  RLG  
Sbjct: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658

Query: 1005 RKQ 1007
             +Q
Sbjct: 1659 LQQ 1661



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 151/690 (21%), Positives = 278/690 (40%), Gaps = 91/690 (13%)

Query: 355  QIESLKREVEMLRSELEK-------IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            Q+ +LK E E  R EL++       I+  ++  I++ ++++  L   L    +Q Q+  V
Sbjct: 834  QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLREEAERKASAT-EARYNKLKEKHSELVHVHAELLR 466
              ++L  +L+ L+       +     E   RKA    E    +L ++ +       E L 
Sbjct: 894  RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE 953

Query: 467  KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVK---RESELKLEEKSDQLEKLKRELEA 523
            +     +Q   TQ + + + R  EQ+  ++E+++    ES+ + +E+  Q E   RE+  
Sbjct: 954  EQQ--GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE---REVAR 1008

Query: 524  KAGELARAQEALSHTEQSKSELSSRLDTLSAE--------KDALSGAVRQREADLLAAQS 575
               E  RAQ  L+  + +++EL  RL     E        ++AL+ A+ ++E        
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068

Query: 576  LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGIL 635
            L R  EAA  +E +   Q   +L+ +LA++E            ++ A   GA +EAAG  
Sbjct: 1069 L-RGLEAAQIKELEELRQTVKQLKEQLAKKE------------KEHASGSGAQSEAAGRT 1115

Query: 636  QDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRF 695
            +    KL+    LR   S   L  + Q+  +   +LE        S A+  + +  L   
Sbjct: 1116 EPTGPKLE---ALRAEVSK--LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170

Query: 696  SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARAL-ELMGQLQDQQALRHMQASLVR 754
                A  +  G + S LA          T  +  ++A  E   Q+   +     + SL+ 
Sbjct: 1171 LEEKAQEL--GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 755  TPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVR--RIEDMMNQARHA- 811
            +  + +  L +++  K  +   +EL  +V  E +  S  +E+ +R  + E   N AR A 
Sbjct: 1229 SLEEEVSILNRQVLEK--EGESKELKRLVMAE-SEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 812  -SSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTE 870
             SS ++ EV          L +        S +L++E+      A   +E   +   W E
Sbjct: 1286 RSSALREEVQ--------SLREEAEKQRVASENLRQELTSQAERA---EELGQELKAWQE 1334

Query: 871  GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSP 930
                  +A+     QL   + + ++      EL+   H      A+  AA K        
Sbjct: 1335 KFFQKEQAL--STLQLEHTSTQALV-----SELLPAKHLCQQLQAEQAAAEK-------R 1380

Query: 931  HLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLEL 990
            H   L++  +      A ++ + +   E I             ++ K  E E   + L  
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIP------------LRQKVAEQERTAQQLRA 1428

Query: 991  EKTLEAERMRLGELRKQHYVLAGASGSPGE 1020
            EK   AE++ +  L+K H +LA  +   GE
Sbjct: 1429 EKASYAEQLSM--LKKAHGLLAEENRGLGE 1456



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 67/265 (25%), Positives = 121/265 (45%), Gaps = 47/265 (17%)

Query: 347  SVKDDRDLQIESLKREVEMLRSELE-----------KIKLEAQRYIAQ---LKSQVNALE 392
            +V+ D + ++  ++RE +    ELE           K+  E QR+  +   L +QV  LE
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541

Query: 393  GELEEQRKQKQ---KALVDNEQL-RHELAQLRAAQLEGERSQGLREEAERKASATEARYN 448
                EQ KQ +   K L D++Q  + +  +L+A Q +G  SQ   +  + + +  +A+ +
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 449  KLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLE 508
            + KE+ +E   +  E  + + D  K     QQ+QE    ++EQL   +EQ+++E+     
Sbjct: 1602 Q-KEQAAEHYKLQMEKAKTHYDAKK-----QQNQE----LQEQLR-SLEQLQKEN----- 1645

Query: 509  EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA 568
                  ++L+ E E    EL +A       EQ+   L++++ +L A+       V   + 
Sbjct: 1646 ------KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ-------VAHADQ 1692

Query: 569  DLLAAQSLVRETEAALSREQQRSSQ 593
             L         T+A  SRE Q   Q
Sbjct: 1693 QLRDLGKFQVATDALKSREPQAKPQ 1717


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 144/711 (20%), Positives = 298/711 (41%), Gaps = 83/711 (11%)

Query: 351  DRDLQIESLKREVEMLRSELEKIKLEAQRYI----------AQLKSQVNA---------- 390
            ++ L  E+   E+E L+S+L   KL+ Q  +           +L++++ A          
Sbjct: 859  EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918

Query: 391  -LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK 449
             LE  +EE+ ++ Q    + ++++  + +L   QLE E S   R++ + +   TEA+  K
Sbjct: 919  DLEARVEEEEERCQHLQAEKKKMQQNIQELE-EQLEEEES--ARQKLQLEKVTTEAKLKK 975

Query: 450  LKEKHSELVHVHAELLRKN-------ADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRE 502
            L+E+   L   + +L ++        A+    LT  ++  + +A++K +    +  +  E
Sbjct: 976  LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL--E 1033

Query: 503  SELKLEEKSDQ-LEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
              L+ EEK  Q LEK +R+LE  + +L+   + ++  +   +EL  +L     E  A   
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLS---DQIAELQAQIAELKMQLAKKEEELQAALA 1090

Query: 562  AVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
             V +  A    A   +RE E+ +S  Q+       +L+   A R   E+  ++R L E+ 
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQE-------DLESERASRNKAEK--QKRDLGEEL 1141

Query: 622  AVLRGA---AAEAAGILQDAVSKLDDPLH-LRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 677
              L+       ++    Q+  SK +  ++ L+ T   +     AQ     +  + + H+Q
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ-----IQEMRQKHSQ 1196

Query: 678  YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 737
             +  LA+       +      A  T+ N      LA  +    L+    +   +  ++  
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLEN--ERGELA--NEVKVLLQGKGDSEHKRKKVEA 1252

Query: 738  QLQDQQALRHMQASLVRTPL-QGILQLGQEL-KPKSLDVRQEELGAVVDKEMAATSAAIE 795
            QLQ+ Q ++  +   VRT L   + +L  EL     L  + +   + + K+ +A  + ++
Sbjct: 1253 QLQELQ-VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311

Query: 796  DAVRRIEDMMNQARHASSGVKLEVNERILNSCTD-----------LMKAIRLLVTTSTSL 844
            D    +++   Q    S+ +K   +E+  NS  +           L K I  L      +
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEK--NSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369

Query: 845  QKEIVESGRGAATQQEFYAKNSRWTEGL-------ISASKAVGWGATQLVEAADKVVLHT 897
            +K++ +S     T +E   K  +  EGL       ++A   +    T+L +  D +++  
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429

Query: 898  GKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQ 957
                +      +      QL+A  K  + K++    R +  +R    +A ++  + +   
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489

Query: 958  EQIEDRDTMDFS-GLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
            EQ  + + ++      +  L   + +    V ELEK+  A   ++ E++ Q
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 153/764 (20%), Positives = 313/764 (40%), Gaps = 138/764 (18%)

Query: 345  NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEG----------- 393
            N + ++++   +  LK + E + ++LE+     ++   +L+     LEG           
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 394  ------ELEEQRKQKQKAL------VDNEQLRHELAQLRAAQLEGERSQGLREEAERKAS 441
                  EL+ Q  +K++ L      V+ E  +  +A  +  +LE + S+ L+E+ E + +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERA 1125

Query: 442  ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL-------AF 494
            +      + ++   EL  +  EL      TA Q  +  + ++EV  +K+ L         
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185

Query: 495  QVEQVKRESELKLEEKSDQ----------LEKLKRELEAKAGELARAQEAL--------- 535
            Q+++++++    +EE ++Q          LEK K+ LE + GELA   + L         
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245

Query: 536  ----------------SHTEQSKSELSSRLDTLSAEKDALSGAVRQREA-------DLLA 572
                            +  E+ ++EL+ ++  L  E D ++G + Q ++       D  A
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305

Query: 573  AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRL---------LDEQFAV 623
             +S +++T+  L    Q  ++++  L  +L + E ++   R++L         L++Q A 
Sbjct: 1306 LESQLQDTQELL----QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDY--LVSRAQEALDAVSTLEEGHAQYLTS 681
            L    A+    ++D+V  L+    ++     D   L  R +E + A   LE+   +    
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421

Query: 682  LAD-----------ASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGA 730
            L D           A  L     +F  L A+       T      +  DR     RE   
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE-----KTISAKYAEERDRAEAEAREKET 1476

Query: 731  RALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV---DKEM 787
            +AL L   L++       +A L R   Q   ++   +  K      +++G  V   +K  
Sbjct: 1477 KALSLARALEEAM---EQKAELERLNKQFRTEMEDLMSSK------DDVGKSVHELEKSK 1527

Query: 788  AATSAAIEDAVRRIEDMMNQARHASSG-VKLEVNERILNSCTDLMKAIRLLVTTSTSLQK 846
             A    +E+   ++E++ ++ +      ++LEVN + + +     + ++     S   +K
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA--QFERDLQGRDEQSEEKKK 1585

Query: 847  EIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQL---VEAA----DKVVLHTGK 899
            ++V   R    + E   K        ++A K +      L   +++A    D+ +    K
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMA---VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642

Query: 900  YE-ELIVCSHEI---AASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKS 955
             + ++  C  E+    AS  +++A +K    K     S   E  +   E AA   A  ++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEAEMIQLQEELAAAERAKRQA 1699

Query: 956  GQEQIEDRDTM-DFSGLSLIKLKKQEMETQVRVLELEKTLEAER 998
             QE+ E  D + + SG   + L +++   + R+ +LE+ LE E+
Sbjct: 1700 QQERDELADEIANSSGKGALAL-EEKRRLEARIAQLEEELEEEQ 1742



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 153/721 (21%), Positives = 285/721 (39%), Gaps = 107/721 (14%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++E +  ++E    E E+     Q    +++  +  LE +LEE+   +QK  ++      
Sbjct: 912  ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971

Query: 415  ELAQLRAAQ--LEGERSQGLREE-------AERKASATEARYN-----KLKEKHSELVHV 460
            +L +L   Q  LE +  +  +E+       AE   + TE         KLK KH  ++  
Sbjct: 972  KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031

Query: 461  HAELLRKNADTAKQLTVTQQSQE--------EVARVKEQLA-FQVEQVKRESEL------ 505
              E LR+     ++L  T++  E        ++A ++ Q+A  +++  K+E EL      
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091

Query: 506  -------------KLEEKSDQLEKLKRELEAKAGELARAQEAL----SHTEQSKSELSSR 548
                         K+ E   Q+ +L+ +LE++     +A++         E  K+EL   
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151

Query: 549  LDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQEQGELQGRL---- 602
            LD+ +A+++  S   R++E ++L    +   +  EA +   +Q+ SQ   EL  +L    
Sbjct: 1152 LDSTAAQQELRS--KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209

Query: 603  ---AERESQEQGL---RQRLLDEQFAVLRGAA------AEAAGILQDAVSKLDDPLHLRC 650
               A  E  +Q L   R  L +E   +L+G         +    LQ+   K ++   +R 
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR- 1268

Query: 651  TSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATS 710
            T   D +     E  +    L +  ++      D SAL + L     L  +   N    S
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE--NRQKLS 1326

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQ---GILQLGQEL 767
                    +   ++ RE      E    L+ Q A  H Q + ++  ++   G L+  +E+
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386

Query: 768  KPK------SLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARH-ASSGVKLEVN 820
            K K       L  R EE  A  DK +  T   ++   + ++D++    H   S   LE  
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDK-LEKTKTRLQ---QELDDLLVDLDHQRQSACNLEKK 1442

Query: 821  ERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG 880
            ++         K  +LL    T   K   E  R  A  +E   K        +S ++A+ 
Sbjct: 1443 QK---------KFDQLLAEEKTISAKYAEERDRAEAEAREKETK-------ALSLARALE 1486

Query: 881  WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKV---KANKHSPHLSRLQE 937
                Q  E          + E+L+    ++  S  +L  + +    +  +    L  L++
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546

Query: 938  CSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
              +   +    +  + ++ + Q E RD       S  + KK+++  QVR  E+E  LE E
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFE-RDLQGRDEQS--EEKKKQLVRQVR--EMEAELEDE 1601

Query: 998  R 998
            R
Sbjct: 1602 R 1602



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 73/334 (21%), Positives = 141/334 (42%), Gaps = 57/334 (17%)

Query: 355  QIESLKREVEMLRSELE-----KIKLE--------------------AQRYIAQLKSQVN 389
            Q+E +K ++E L  EL+     K++LE                    ++    QL  QV 
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592

Query: 390  ALEGELEEQRKQKQKALVDNEQLRHELAQLRA----------------AQLEGERSQGLR 433
             +E ELE++RKQ+  A+   ++L  +L  L A                 +L+ +    +R
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 434  EEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
            E  + +AS  E    + KE   +L  + AE+++   + A      +Q+Q+E    +++LA
Sbjct: 1653 ELDDTRASREEI-LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE----RDELA 1707

Query: 494  FQVEQVKRESELKLEEK---SDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLD 550
             ++     +  L LEEK     ++ +L+ ELE + G      + L        ++++ L+
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767

Query: 551  TLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
               +       A +Q E      +  ++E E  +  + + S      L+ ++A+ E Q  
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT---ALEAKIAQLEEQ-- 1822

Query: 611  GLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
             L     + Q A  +    E    L+D + ++DD
Sbjct: 1823 -LDNETKERQAACKQVRRTEKK--LKDVLLQVDD 1853



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 60/277 (21%), Positives = 126/277 (45%), Gaps = 25/277 (9%)

Query: 351  DRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE 410
            ++  ++E L ++      +L   K +  + + +L+    ALE ++EE + Q        E
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL-------E 1542

Query: 411  QLRHELAQLRAAQLEGE-RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            +L  EL     A+L  E   Q ++ + ER     + R  + +EK  +LV    E+  +  
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERD---LQGRDEQSEEKKKQLVRQVREMEAELE 1599

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGEL- 528
            D  KQ ++   +++++    + L   ++   +      +E   QL KL+ +++    EL 
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR----DEAIKQLRKLQAQMKDCMRELD 1655

Query: 529  ---ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVR-----QREADLLAAQSLVRET 580
               A  +E L+  ++++ +L S    +   ++ L+ A R     Q+E D LA +      
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715

Query: 581  EAALSREQQRSSQEQ-GELQGRLAERESQEQGLRQRL 616
            + AL+ E++R  + +  +L+  L E +   + +  RL
Sbjct: 1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 54/247 (21%), Positives = 106/247 (42%), Gaps = 26/247 (10%)

Query: 357  ESLKREVEMLRSEL----------------EKIKLEAQRYIAQLKSQVNALEG--ELEEQ 398
            E  KR+ +  R EL                EK +LEA+  IAQL+ ++   +G  EL   
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR--IAQLEEELEEEQGNTELIND 1750

Query: 399  RKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELV 458
            R +K    +D       L +  A + E  R Q  R+  E K    E       +  + + 
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810

Query: 459  HVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA---FQVEQVKRESEL---KLEEKSD 512
             + A++ +       +    Q + ++V R +++L     QV+  +R +E    + ++ S 
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870

Query: 513  QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLA 572
            +L++LKR+LE    E  RA  +    ++   + +   D ++ E  +L   +R+ +   + 
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVV 1930

Query: 573  AQSLVRE 579
             + + R+
Sbjct: 1931 PRRMARK 1937



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 76/348 (21%), Positives = 154/348 (44%), Gaps = 33/348 (9%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            + +  + + L  E + + ++  + +  A+    + +++  +L   LEE  +QK +    N
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            +Q R E+  L +++ +  +S     E E+   A E +  ++K +  EL     + L+   
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSV---HELEKSKRALEQQVEEMKTQLEEL----EDELQATE 1552

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
            D   +L V  Q+      +K Q    ++    +SE K ++   Q+ +++ ELE +  + +
Sbjct: 1553 DAKLRLEVNLQA------MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606

Query: 530  RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA------A 583
             A  A    E    +L + +D+ +  +D     +R+ +A +      + +T A      A
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666

Query: 584  LSREQQRS----SQEQGELQGRLAERE---SQEQGLRQRLLDE-QFAVLRGA-AAEAAGI 634
             ++E ++       E  +LQ  LA  E    Q Q  R  L DE   +  +GA A E    
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726

Query: 635  LQDAVSKLDDPLHLR--CTSSPDYLVSRAQEALDAVST---LEEGHAQ 677
            L+  +++L++ L      T   +  + +A   +D ++T   LE  HAQ
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 116/563 (20%), Positives = 212/563 (37%), Gaps = 80/563 (14%)

Query: 482  QEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQS 541
            QEE    KE+   +V    RE +L  E +  ++E L+ +L A   E  + QE L    Q+
Sbjct: 843  QEEEMMAKEEELVKV----REKQLAAENRLTEMETLQSQLMA---EKLQLQEQL----QA 891

Query: 542  KSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGR 601
            ++EL +  + L A   A    + +   DL A      E    L  E+++  Q   EL+ +
Sbjct: 892  ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951

Query: 602  LAERESQEQGL---------RQRLLDEQFAVLRG---AAAEAAGILQDAVSKLDDPL--- 646
            L E ES  Q L         + + L+E+  +L       A+   +L+D +++    L   
Sbjct: 952  LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011

Query: 647  -----------------------HLRCTSSPDYLVSRAQEALDAVST-LEEGHAQYLTSL 682
                                    LR        + + +  L+  ST L +  A+    +
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071

Query: 683  ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
            A+    +A        A   +    A  ++A        +   RE  ++  EL   L+ +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMA--------LKKIRELESQISELQEDLESE 1123

Query: 743  QALRHMQASLVRTPLQGILQLGQELKPKSLD--VRQEELGAVVDKEMAATSAAIEDAVRR 800
            +A R+      R   + +  L  EL+  +LD    Q+EL +  ++E+      +E+  + 
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELE-DTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182

Query: 801  IEDMMNQARHASSGVKLEVNERILNS---CTDLMKAIRLLVTTSTSLQKEIVESGRGAAT 857
             E  + + R   S    E+ E++  +     +L KA + L      L  E+    +G   
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242

Query: 858  QQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
             +    K  +    L         G     E ADKV        +L V    +    +Q 
Sbjct: 1243 SEH---KRKKVEAQLQELQVKFNEGERVRTELADKVT-------KLQVELDNVTGLLSQS 1292

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIED-----RDTMDFSGLS 972
             + S       S   S+LQ+    + E     + S  +  +Q+ED     R+ ++    +
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKL-SLSTKLKQVEDEKNSFREQLEEEEEA 1351

Query: 973  LIKLKKQEMETQVRVLELEKTLE 995
               L+KQ      +V +++K +E
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKME 1374



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 66/307 (21%), Positives = 120/307 (39%), Gaps = 32/307 (10%)

Query: 715  TDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV 774
            T     L + C +  AR  E      +++  +H+QA   +   Q I +L ++L+      
Sbjct: 907  TAKKQELEEICHDLEARVEE------EEERCQHLQAEKKKMQ-QNIQELEEQLE------ 953

Query: 775  RQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM--- 831
             +E     +  E   T A ++        + +Q    +   KL + +RI    T+L    
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL-LEDRIAEFTTNLTEEE 1012

Query: 832  ---KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVE 888
               K++  L     ++  ++ E  R    Q++   K  R  EG   ++      A    +
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--DSTDLSDQIAELQAQ 1070

Query: 889  AADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAAN 948
             A+  +    K EEL      +    AQ   A K K  +    +S LQE   +  ERA+ 
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLES--ERASR 1127

Query: 949  VVASTKS---GQE----QIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRL 1001
              A  +    G+E    + E  DT+D +        K+E E  +    LE+  +    ++
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187

Query: 1002 GELRKQH 1008
             E+R++H
Sbjct: 1188 QEMRQKH 1194


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 69/270 (25%), Positives = 126/270 (46%), Gaps = 22/270 (8%)

Query: 352 RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
           R L+ + L+RE +    + ++++ E Q    Q + +    E   E+Q +++Q+     +Q
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338

Query: 412 LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
           LR E  + R  QL  E+ +  RE+  R+    E R  +L+ +                  
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE------------------ 380

Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
            +QL   QQ + E    +EQ   + +Q++RE +L+ E++  + ++L+RE E +  E    
Sbjct: 381 -QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLV-RETEAALSREQQR 590
           QE     ++ K E   R D L  E++       +R+  L   Q    RE    L  E++R
Sbjct: 440 QE--RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497

Query: 591 SSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
             QE+ E Q R  + E +EQ L+++  +E+
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEER 527



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 79/273 (28%), Positives = 126/273 (46%), Gaps = 24/273 (8%)

Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELE---EQRKQKQKALVDNEQLR 413
           + L+RE E  R +  + + E +R   QL+ +      E +   EQ+ ++++ L   +QLR
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396

Query: 414 HELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E    R  QL  E    R Q LR E + +    E R+ +  E+      +  E   +  
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE-QEERR 455

Query: 470 DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
           D  K+   T++ ++E  R K+QL    E+ +RE  LKLEE     E+ + + E +  +L 
Sbjct: 456 DWLKREEETERHEQE--RRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLR 508

Query: 530 RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSRE-- 587
           R QE        + E   RL      +  L     +RE +    Q L RE E  L +E  
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQL-----RREQEERREQLLKREEEKRLEQERR 563

Query: 588 QQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
           +QR  +EQ E + +L +RE  E+  +QRL  EQ
Sbjct: 564 EQRLKREQEERRDQLLKRE--EERRQQRLKREQ 594



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 77/276 (27%), Positives = 130/276 (47%), Gaps = 30/276 (10%)

Query: 357 ESLKREVEMLRSELEKI---KLEAQRYIAQLKSQVNAL--------EGELEEQRKQKQKA 405
           + L+RE ++ R + E+    K E +R   +LK +            E E  EQ ++KQ+ 
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476

Query: 406 LVDNEQLRHELAQLRAAQLEGE--RSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
             D E+ R E    R  +LE E  R Q  R E + +    E R  +LK +  E      E
Sbjct: 477 KRDQEEERRE----RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE------E 526

Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
            L++   + +QL   Q+ + E    +E+   ++EQ +RE  LK E++  + + LKRE E 
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEER 585

Query: 524 KAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
           +   L R QE        + E+  RL+    +++     +++ E +    Q L++  E  
Sbjct: 586 RQQRLKREQEERLEQRLKREEVE-RLE----QEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 584 LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDE 619
             R+QQ   ++Q   + RL +RE +E+ L QRL  E
Sbjct: 641 ERRQQQLRREQQERREQRL-KREEEEERLEQRLKRE 675



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 70/269 (26%), Positives = 131/269 (48%), Gaps = 21/269 (7%)

Query: 357 ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQL-RHE 415
           + L+RE ++ R +  + + E +R+  + K +    E  L+ ++++++  L   E+  RHE
Sbjct: 411 QQLRREQQLRREQQLRREQEEERH--EQKHEQERREQRLKREQEERRDWLKREEETERHE 468

Query: 416 LA----QLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
                 QL+  Q E  R + L+ E E +    E R  +L+ +  E      E   K  + 
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE----RREQRLKRQEE 524

Query: 472 AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARA 531
            ++L    +S++++ R +E+   Q+  +KRE E +LE++  + ++LKRE E +  +L + 
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQL--LKREEEKRLEQERRE-QRLKREQEERRDQLLKR 581

Query: 532 QEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRS 591
           +E     ++ K E   RL+     ++     V + E +    Q L RE      R+Q   
Sbjct: 582 EEE-RRQQRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEEERRQQLLK 635

Query: 592 SQEQGELQGRLAERESQEQGLRQRLLDEQ 620
           S+EQ E + +   RE QE+   QRL  E+
Sbjct: 636 SEEQEERRQQQLRREQQER-REQRLKREE 663



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 70/275 (25%), Positives = 127/275 (46%), Gaps = 26/275 (9%)

Query: 349 KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
           ++ ++ + + L+RE E  R +  K + E +R   +L+S+   L  E EE+R+Q  K   +
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQLLKREEE 555

Query: 409 NEQLRHELAQLRAAQLEGERSQGLREEAER-----KASATEARYNKLKEKHSELVHVHA- 462
               +    Q    + E  R Q L+ E ER     K    E    +LK +  E +     
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 463 --ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE-KLKR 519
             + L++     ++     +S+E+  R ++QL  + +Q +RE  LK EE+ ++LE +LKR
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKREEEEERLEQRLKR 674

Query: 520 ELEAKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQS 575
           E E +  E   A+E     EQ++  + SR+      L +E DA    V  R         
Sbjct: 675 EHEEERREQELAEE---EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK------ 725

Query: 576 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQ 610
             +E +     ++++  + + ELQ +  ER  ++Q
Sbjct: 726 --QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 73/276 (26%), Positives = 126/276 (45%), Gaps = 28/276 (10%)

Query: 357 ESLKREVEMLRS----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ- 411
           E  + E E L+S    E E+   E Q    +L         E ++QR+++Q  +   E+ 
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243

Query: 412 ---------LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
                    LR E  +L+  + + +R     EE  RK    E R  + +E+  +      
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ------ 297

Query: 463 ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522
           + LR+     ++    ++ Q+E  R +++   Q E+ +RE +L+ E++  + ++L+RE E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEE-RREQQLRREQEERREQQLRREQE 356

Query: 523 AKAGE--LARAQEALSHTEQSKSELSSRLDT-LSAEKDALSGAVRQREADLLAAQSLVRE 579
            +  E  L R QE     +Q + E   R +  L  E+        +RE  L   Q L RE
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416

Query: 580 TEAALSREQQ-RSSQEQGELQGRLAERESQEQGLRQ 614
            +  L REQQ R  QE+ E   +  E+E +EQ L++
Sbjct: 417 QQ--LRREQQLRREQEE-ERHEQKHEQERREQRLKR 449



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 74/280 (26%), Positives = 127/280 (45%), Gaps = 29/280 (10%)

Query: 357  ESLKREVE-MLRSELEKIKLEAQ----RYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            E L++E E +LR E EK + + +    R   +L+ +   L GE  E+R+++++     ++
Sbjct: 934  EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER----EKK 989

Query: 412  LRHELAQLRAAQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNAD 470
             R E       +L+ E  Q LREE E R+    E +Y K  E   E      +LLR+  +
Sbjct: 990  YREE------EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE----EEQLLREERE 1039

Query: 471  TAKQLTVTQQ--SQEEVARVKEQLAFQVEQVKRESEL-----KLEEKSDQLEKLKRELEA 523
              +     +Q   +EE+ + +EQL  +  + +R  EL     K EE   + E+L RE   
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099

Query: 524  KAGELARAQEALSHTE-QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRET-E 581
            K     R ++     E Q + E   R +     +  L    R+ E      + L+RE  E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159

Query: 582  AALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
                +E +R  +E+ ELQ    +   +EQ  R++  + Q+
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 30/288 (10%)

Query: 360  KREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL 419
            +   + L+ E + ++ + +R  +Q + +      +LEE+RK+++  L     L+ +L + 
Sbjct: 843  RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902

Query: 420  RAAQLEGERSQGLREEAERKASATEARY---NKLKEKHSELVHVHAELLR---KNADTAK 473
            +    E E      E  +R+    E +Y    +L+++  +L+    E  R   +     K
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE---------AK 524
               + Q+ ++ +    E+   Q  + K   E +L+++ +QL + +RE            K
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 525  AGELARAQEALSHTEQSKSELSSR------LDTLSAEKDALSGAVRQR------EADLLA 572
              EL + +E L   E+ K  L  R       + L  E++ L G  R+       E     
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082

Query: 573  AQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
             + L +E E  L  E ++  +++ E Q R  E   QE+   ++LL E+
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE---EQLLREE 1127



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 59/234 (25%), Positives = 103/234 (44%), Gaps = 34/234 (14%)

Query: 392 EGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATE-ARYNKL 450
           E +L+E+  Q+Q+ L + E+   +L          ER +  RE  E +       R  +L
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKL----------ERQELRRERQEEEQQQQRLRREQQL 306

Query: 451 KEKHSELVHVHAELLRKNADTAKQLTVTQQSQ---EEVARVKEQLAFQVEQVKRESELKL 507
           + K  E      E  R+  +  +Q    ++ Q   E+  R ++QL  + E+ +RE +L+ 
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366

Query: 508 EEKSDQLE-KLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
           E++ ++ E +L+RE + +  +  R ++ L   +Q + E   R                 R
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----------------R 409

Query: 567 EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
           E  L   Q L RE +  L REQ+    EQ   Q R  +R  +EQ  R+  L  +
Sbjct: 410 EQQLRREQQLRREQQ--LRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 73/304 (24%), Positives = 133/304 (43%), Gaps = 47/304 (15%)

Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGEL---EEQRKQKQK 404
           ++ ++ L+ E  +R  ++L+ E EK +LE +R   +LK +      +L   EE+R+Q++ 
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQRL 590

Query: 405 ALVDNEQLRHELAQLRAAQLEGE----------------RSQGLREEAER-------KAS 441
                E+L   L +    +LE E                R Q L+ E +        +  
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 442 ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEV-ARVKE-----QLAFQ 495
             E R  +LK +  E   +   L R++ +  ++  + ++ QE+   R+K      Q   +
Sbjct: 651 QQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709

Query: 496 VEQVKRESELKLEEKSDQLEKLKRELEAK----AGELARAQEALSHTEQSKSELSSRLDT 551
            E   R+S++    +  + ++ ++E E K      EL   +E  +H +Q + E   R  T
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE-QRRDFT 768

Query: 552 LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQG 611
              + +  S   RQR    L+A+  +RE      R ++R  +E    Q  L E E +EQ 
Sbjct: 769 WQWQAEEKSERGRQR----LSARPPLREQRERQLRAEERQQRE----QRFLPEEEEKEQR 820

Query: 612 LRQR 615
            RQR
Sbjct: 821 RRQR 824



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 67/287 (23%), Positives = 122/287 (42%), Gaps = 29/287 (10%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
            + DRD +     RE E LR E E+ +L  Q    + +     LE +   +++Q++K + D
Sbjct: 1550 RQDRDRKF----REEEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQERKFMED 1600

Query: 409  NEQLRHELAQLRAAQ-------------LEGERSQGLREEAERKASATEARYNKLKEKHS 455
             +QLR +  Q +  Q              E E  Q  R+E +RK    E +  + +E+  
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR-QEREQ 1659

Query: 456  ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLE 515
            +L H      R+     ++    Q  ++E  R   +   Q+ + +RE +   EE+  + +
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719

Query: 516  KLKREL-EAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
            +L+R+  E +       QE L   E+ +  L         E+  L    R R+       
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779

Query: 575  SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
               RE +   S+E  R  +E+ +L+     +E +EQ LR +  D ++
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLR-----QEREEQQLRPQQRDGKY 1821



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 60/278 (21%), Positives = 134/278 (48%), Gaps = 14/278 (5%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
            + +RD +    +++V   R E E+  LE ++ + Q + +    E +L ++R+++Q    +
Sbjct: 1425 RQERDRKFREEEQQVR--RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482

Query: 409  NEQ-LRHELAQLRAAQLEGE-RSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELL 465
             ++    E  QLR  + + + R Q LR +E ERK    E + ++ +++  + +    +L 
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR-QQRQRKFLQEEQQLR 1541

Query: 466  RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
            R+     ++    ++ +EE    +E+   Q+ + +R+ + +LEE+  + ++ +R+     
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 526  GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR--ETEAA 583
             +L R QE      Q +       + L  E++      ++R+   L  +  +R  E E  
Sbjct: 1602 QQL-RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660

Query: 584  LSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQF 621
            L  ++ R  +E+ +L      +E +EQ LR++  D +F
Sbjct: 1661 LRHDRDRKFREEEQLL-----QEGEEQQLRRQERDRKF 1693



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 60/286 (20%), Positives = 124/286 (43%), Gaps = 24/286 (8%)

Query: 348 VKDDRDLQIESLKREVE------MLRSELEKIKLEAQRYIAQLKSQV-------NALEGE 394
           +K + + + + LKRE E      + R E+E+++ E +R   +LK +          L+ E
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKREEPEEERRQQLLKSE 637

Query: 395 LEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKH 454
            +E+R+Q+Q      E+    L +    +   +R +   EE  R+    E    + +E+ 
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697

Query: 455 SELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQL 514
              +      L   AD  +    ++  ++E  R ++    + E+ +R  E +L+ + ++ 
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ----EQEEKRRRRESELQWQEEER 753

Query: 515 EKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
              +++ E +  +     +A   +E+ +  LS+R       +  L    RQ+       Q
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-----EQ 808

Query: 575 SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
             + E E    R +QR  +E+ ELQ    E + Q +   Q+L +E+
Sbjct: 809 RFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQRRERAQQLQEEE 853



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 66/264 (25%), Positives = 118/264 (44%), Gaps = 25/264 (9%)

Query: 366  LRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQL----RA 421
            LR + E+ +L A+    Q + Q    E E +EQR+++++      Q   E  QL    RA
Sbjct: 790  LREQRER-QLRAEE--RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846

Query: 422  AQLEGERSQGLREEAERKASATEARYNK----LKEKHSELVHVHAELLRKNADTAKQLTV 477
             QL+ E   GL+E+ ER+ S  + R  K    L+E+     H             K+  +
Sbjct: 847  QQLQ-EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905

Query: 478  TQQSQEEVARVKEQLAFQVEQVKR-ESELKLEEKSDQLEKLKRELEAKAGELARAQEALS 536
             Q+ +EE+ R + +   + EQ ++   E +L+++ +QL + +RE         R QE   
Sbjct: 906  LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR-------RRQERER 958

Query: 537  HTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQG 596
               + K         L  E +      ++RE      + L +E E  L  E+++  +++ 
Sbjct: 959  QYRKDKKLQQKEEQLLGEEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016

Query: 597  ELQGRLAERESQEQGLRQRLLDEQ 620
            E Q R  +   QE+   ++LL E+
Sbjct: 1017 ERQYRKKDELQQEE---EQLLREE 1037



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 63/268 (23%), Positives = 114/268 (42%), Gaps = 34/268 (12%)

Query: 362  EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA 421
            E ++ R E ++   E ++ + + + +   L+ E + +R++ ++   + EQLR E  Q + 
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740

Query: 422  AQLEGERS----QGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTV 477
             + E  R     + LR E E +    + R  K +E+         + LR      K    
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800

Query: 478  TQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSH 537
             Q  QE   R ++QL  Q    +R+ + + EE+  QLE+ ++ L  +     RA+E  + 
Sbjct: 1801 EQLRQE---REEQQLRPQ----QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853

Query: 538  TEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGE 597
             E+S+ E                    ++E      Q   +E E  L  E  R  Q++ +
Sbjct: 1854 QEKSRRE--------------------EQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893

Query: 598  LQGRLAERESQEQGLRQRLLD---EQFA 622
               ++ E +SQE     RLL+    QFA
Sbjct: 1894 RHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 79/299 (26%), Positives = 131/299 (43%), Gaps = 45/299 (15%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQ---LKSQVNALEGELEEQRK----- 400
            +++ +LQ E    E ++LR E EK + E +R   +   L+ Q        E+QR      
Sbjct: 1171 REEEELQQE----EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226

Query: 401  ---QKQKALVDN---------EQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARY 447
               +K+ A+ DN         EQ R  E +QLR  Q + +    L E+ ER       R+
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +      E      +L R+    AK+    ++SQEE   ++E+   + ++ ++E++ K 
Sbjct: 1287 QQRDRHFPE----EEQLEREEQKEAKRRD--RKSQEEKQLLREER--EEKRRRQETDRKF 1338

Query: 508  EEKSDQL-EKLKRELEAKAGELARAQEALSHTEQSKS--ELSSRLDTLSAEKDALSGA-- 562
             E+   L E+ ++ L  +  +    +E L H EQ +   E   RL     E+  L     
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398

Query: 563  --VRQREADLLAAQSL-VRETEAALSREQQRSSQEQGELQGRLAERE----SQEQGLRQ 614
               ++RE  L   +    RE E  LSR+++     + E Q R  ERE     +EQ LRQ
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 77/282 (27%), Positives = 122/282 (43%), Gaps = 39/282 (13%)

Query: 347 SVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
           S K +R  Q +  +R+ E+ R   E  + E +R          A E +L+  +  + +  
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERR----------AEEEQLQSCKGHETEEF 204

Query: 407 VDNEQLRH-ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
            D EQLR  EL +LR    E E+ Q  RE  +R     E +  + +E           +L
Sbjct: 205 PDEEQLRRRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRET----------VL 253

Query: 466 RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
           RK  +  ++     Q Q E+   +EQL  ++E+ +   E + EE+  Q  + +++L  K 
Sbjct: 254 RKEEEKLQE--EEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQ 310

Query: 526 GELARAQEALSHTEQSKSELSS--RLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAA 583
            E  R Q+     +Q + E     R   L  E++       +RE  L   Q   R  E  
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQE------ERREQQLRREQEEERR-EQQ 363

Query: 584 LSREQQRSSQEQGELQGRLAERESQ---EQGLR--QRLLDEQ 620
           L REQ+   +EQ   + +   RE Q   EQ LR  Q+L  EQ
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 70/278 (25%), Positives = 119/278 (42%), Gaps = 25/278 (8%)

Query: 351  DRDLQIESLKR------EVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ--RKQK 402
            +R+ Q E+ +R      E ++LR E E+ K   Q    + + +   L+ E EEQ  R+Q+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREE-KRRRQETDRKFREEEQLLQ-EREEQPLRRQE 1357

Query: 403  QKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHA 462
            +      E+LRH   Q +  +   E  +  R+E ERK          LKE+         
Sbjct: 1358 RDRKFREEELRH---QEQGRKFLEEEQRLRRQERERKF---------LKEEQQLRCQERE 1405

Query: 463  ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            + LR++ D   +    Q S++E  R   +   QV + +RE +   EE+  + E+ ++  E
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
             +     R ++ L   E+ +  L         E+D      R++E      +    E E 
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR---KFREQELRSQEPERKFLEEEQ 1522

Query: 583  ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
             L R+Q++    Q E Q R  ER  Q +  R R   E+
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 67/284 (23%), Positives = 129/284 (45%), Gaps = 33/284 (11%)

Query: 361  REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR 420
            RE E L+ E E++ L  +R   + +        E E Q++++Q    + E+ R +  + +
Sbjct: 1051 REEEELQQEEEQL-LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109

Query: 421  A---AQLEGERSQGLREEAE-RKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLT 476
                 +L+ E  Q LREE E R+    E +Y + +E   E      +LLR+  +  ++  
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE----EEQLLREEPEKRRRQE 1165

Query: 477  VTQQ--SQEEVARVKEQLAFQVEQVKR---------ESELKLEEK------SDQLEKLKR 519
            + +Q   +EE+ + +EQL  + ++ +R         E EL+ +++       DQ   LK 
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225

Query: 520  ELEAKAGELARAQEAL---SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSL 576
            + E +     R  +        EQ +    S+L    +++D       Q+E D    +  
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285

Query: 577  VRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQ 620
             ++ +     E+Q   +EQ E + R  +R+SQE+  +Q L +E+
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRR--DRKSQEE--KQLLREER 1325



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 20/238 (8%)

Query: 387 QVNALEGELEEQRKQKQKALVDN----EQLRHELAQLRAAQLEGERSQGLREEAERKASA 442
           Q   L+ E   +   K+  L D     +Q R E    +  +  G+R +  R+E ER+ + 
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150

Query: 443 TEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQL----AFQVEQ 498
            E +     EK   L     +  R++ +  +Q    Q+ +E  A  +EQL      + E+
Sbjct: 151 GEEQ----SEKQERL--EQRDRQRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEE 203

Query: 499 VKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDA 558
              E +L+  E    L +L+R+   +  +  R ++     E+ + E   R   L  E++ 
Sbjct: 204 FPDEEQLRRRE----LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259

Query: 559 LSGAVRQREADLLAAQSLVRETE-AALSREQQRSSQEQGELQGRLAERESQEQGLRQR 615
           L     QR+ +L   +  +R+ E   L RE+Q   Q+Q  L+     R  QE+  R++
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 121/560 (21%), Positives = 227/560 (40%), Gaps = 82/560 (14%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKS---QVNALEGELEEQRKQKQKALVD 408
            +D  +  L++++  L+S+L++++LE     ++LK+   ++++L+   +  ++Q   A   
Sbjct: 529  KDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588

Query: 409  NEQLRHELAQLRAAQLE--GERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
              +L+ E+A ++  Q+   G       E        TE ++  +KEK      + A+L  
Sbjct: 589  RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKG----RIAAQLQG 644

Query: 467  KNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--------------------LK 506
              AD   Q     Q QE    V+E L  ++E+ + E E                    L 
Sbjct: 645  IEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLT 704

Query: 507  LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
            L ++  QLE L++E      +L   QEAL   EQS   L +  D L A    L G    R
Sbjct: 705  LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASR 764

Query: 567  EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
            E  +   Q+     EAAL  +  +S +E+ +   R  E  ++E       L E+ A+  G
Sbjct: 765  EDTICLLQNEKIILEAAL--QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822

Query: 627  AA---AEAAGILQDAVSKLDDPL---------HLRCTSSPDYLVSRAQ--------EALD 666
                  +    L+  + K+ +           + R  +S D L+S  +        E  +
Sbjct: 823  QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882

Query: 667  AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                L + H +  T+ A+ S L   + +     AD  + G   S     D  +  + + +
Sbjct: 883  LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMAD--LEGHLQSAQKERDEMETHLQSLQ 940

Query: 727  ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKE 786
                   +++   +  +AL+     L +   + I +  Q+++    D+   +      KE
Sbjct: 941  ---FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ------KE 991

Query: 787  MAATSAAIEDAV----RRIEDMMN------------QARHASSGVKLEVNERILNSCTDL 830
            M     A E+AV    RR+++ +             +A+  SS   L ++ERI      L
Sbjct: 992  MKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERI----QAL 1047

Query: 831  MKAIRLLVTTSTSLQKEIVE 850
               ++ +  + T L+KE+ E
Sbjct: 1048 EAELQAVSHSKTLLEKELQE 1067



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 111/468 (23%), Positives = 206/468 (44%), Gaps = 72/468 (15%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK-----------QKQKA 405
            E+LK+++E L+ E  K   E ++ + +L S + + + E++ + K           + Q+A
Sbjct: 954  EALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013

Query: 406  LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
            L   E    EL QLRA     + S  L E  +    A EA    +   HS+ + +  EL 
Sbjct: 1014 LAAKEAADAELGQLRAQGGSSDSSLALHERIQ----ALEAELQAVS--HSKTL-LEKELQ 1066

Query: 466  RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
               A T+++L   ++S+E+V  ++++L     Q  R    K++   +  +KL  ELE + 
Sbjct: 1067 EVIALTSQEL---EESREKVLELEDEL-----QESRGFRKKIKRLEESNKKLALELEHEK 1118

Query: 526  GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALS 585
            G+L      L  +  +  E +S L+T          A+ +READL+    L  + +A L 
Sbjct: 1119 GKLT----GLGQSNAALREHNSILET----------ALAKREADLV---QLNLQVQAVLQ 1161

Query: 586  REQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDP 645
            R+++   Q +  +Q   A  E +++ +    L EQ A  +  A       + A  +L + 
Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNS--LKEQVAAAKVEAGHNRRHFKAASLELSEV 1219

Query: 646  LHLRCTSSPDYLVSRAQEALDAVSTLEEGH----AQYLTSLADASALVAALTR--FSHLA 699
               +   + ++LV + Q   D +   E  H    AQ+   LA+A A +  L +     L+
Sbjct: 1220 --KKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLS 1277

Query: 700  ADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQG 759
               + N    +     D  +R I        ++L+    L +QQ          R  L+G
Sbjct: 1278 KQPVGNQEMENLKWEVDQKEREI--------QSLKQQLDLTEQQG---------RKELEG 1320

Query: 760  ILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQ 807
            + QL Q +K   L++ QE+L ++  K+     A + +    ++ ++ Q
Sbjct: 1321 LQQLLQNVK-SELEMAQEDL-SMTQKDKFMLQAKVSELKNNMKTLLQQ 1366



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 68/280 (24%), Positives = 130/280 (46%), Gaps = 27/280 (9%)

Query: 353  DLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQR--KQKQKALVDNE 410
            + +++++     +L  EL+++     + + + + +V  LE EL+E R  ++K K L ++ 
Sbjct: 1048 EAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESN 1107

Query: 411  -----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
                 +L HE  +L      G+ +  LRE      +A   R   L + +   + V A L 
Sbjct: 1108 KKLALELEHEKGKLTGL---GQSNAALREHNSILETALAKREADLVQLN---LQVQAVLQ 1161

Query: 466  RKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
            RK  +  +   + Q  Q  + + KE++    EQV   +  K+E   +     +R  +A +
Sbjct: 1162 RKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQV---AAAKVEAGHN-----RRHFKAAS 1213

Query: 526  GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRETE 581
             EL+  ++ L   E    +L +  D L   +   S  + Q +A+L  A    Q L ++ +
Sbjct: 1214 LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLD 1273

Query: 582  AALSREQQRSSQEQGELQGRLAERESQEQGLRQRL-LDEQ 620
              LS+ Q   +QE   L+  + ++E + Q L+Q+L L EQ
Sbjct: 1274 EQLSK-QPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ 1312



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 16/234 (6%)

Query: 349  KDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
            K++ D Q++ L   V+ L++ LEK K +    +  LK QV A + E    R+  + A ++
Sbjct: 1163 KEEEDRQMKHL---VQALQASLEKEKEK----VNSLKEQVAAAKVEAGHNRRHFKAASLE 1215

Query: 409  NEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKN 468
              +++ EL      Q +    Q L+ EA+           ++ +  +EL    A+L    
Sbjct: 1216 LSEVKKEL------QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQ 1269

Query: 469  ADTAKQLTVTQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKA 525
                +QL+      +E+  +K   +Q   +++ +K++ +L  ++   +LE L++ L+   
Sbjct: 1270 KQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVK 1329

Query: 526  GELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRE 579
             EL  AQE LS T++ K  L +++  L      L    +Q + DL    +  R+
Sbjct: 1330 SELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 105/474 (22%), Positives = 190/474 (40%), Gaps = 51/474 (10%)

Query: 345 NGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQK 404
           NG V+  RD    S+          LE    E Q  + Q+  +   LEG+LE    +  +
Sbjct: 380 NGEVRSRRDSICSSVS---------LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQ 430

Query: 405 ALVDNEQLRHELAQLRA-AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
           AL +  +L+ +LA L    Q + E S   ++  +  +S  +       +    +  +   
Sbjct: 431 ALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490

Query: 464 LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
           L  KNA  A      Q ++E+  R    L  +VE ++R     +  K + +  L++++ A
Sbjct: 491 LEAKNASLASSNNDLQVAEEQYQR----LMAKVEDMQR----SMLSKDNTVHDLRQQMTA 542

Query: 524 KAGELARAQ----EALSHTEQSKSELSSRLDTLS--AEKDALSGAVRQREADLLAAQSLV 577
              +L + Q       S  + S++E+SS         ++ AL+   R R    +A   + 
Sbjct: 543 LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVG 602

Query: 578 RETEAA----LSREQQRSSQEQGELQGRLAERE----SQEQGLRQRLLDEQFAVLRGAAA 629
           + T+A     L  E    SQ+  E Q R  + +    +Q QG+   +LD++ A ++    
Sbjct: 603 QMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ---- 658

Query: 630 EAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALV 689
                +Q+A + +++ L  R          R Q   D+ ++LE+   Q   +L      +
Sbjct: 659 -----IQEAKTMVEEDLQRRLEEFEGER-ERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712

Query: 690 AALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQL---QDQQALR 746
            AL +  HL     +     +  +     D L     E  AR  EL G+    +D   L 
Sbjct: 713 EALQQ-EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLL 771

Query: 747 HMQASLVRTPLQGILQLGQELK--PKSLDVRQEELGAVVDK---EMAATSAAIE 795
             +  ++   LQ      +EL    + L+   EE    ++K   E+A  S  +E
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE 825


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%)

Query: 349  KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 405
            K   D +++  + E+  L+S++E    + ++ Q+ I +L++++  LE E+E +R  + KA
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 406  LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 461
                  L  EL ++     E   +   + E  +K    EA + K++    E    H    
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195

Query: 462  AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 502
            A L +K+AD+  +L         V Q+ ++E + +K   + LA  VE V +         
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 503  -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 546
                   SELK +E+  Q     L   +  L+ ++GE +R    +EAL S   + K   +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 547  SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 587
             +++ L  +       K+AL+ A++  + + DLL  Q    +E++A L R          
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 588  QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 644
            Q R+  E   +Q R  E E  ++ L QRL   +E    +    A      Q   ++++D 
Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434

Query: 645  PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 699
             L +  T++    + + Q   D +        EE HA+   S  +A +L   L +  +  
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494

Query: 700  ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 743
             +++  +      +         L +   E G R                EL   L++ +
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554

Query: 744  A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
            A L H +  ++R  L   Q   ++ +++  K  ++ Q         E + + +D E+ + 
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614

Query: 791  SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 831
            + AI      E  +  +E  +N A R A+  ++   N +             L S  DL 
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674

Query: 832  KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 891
            + + ++   +  LQ EI E     AT ++         + L+ AS+ V     QL+   +
Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726

Query: 892  KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 950
              +++T K  E  +   +       Q    ++ KA K     + + E  +   + +A++ 
Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786

Query: 951  ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
               K+ ++ ++D      +   L+L   KKQ  + + RV ELE  +E+E+ R  E  K
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%)

Query: 348  VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            +K+  DLQ++        +++E E +    +R    +K+++     +LE + K+  +   
Sbjct: 887  LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
            D E++  EL   +  +LE E S+  ++         + E++  ATE +   L E+ + L 
Sbjct: 934  DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992

Query: 459  HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
               A+L +  K    A Q T+     EE     + + K +L  QV+ ++   E + + + 
Sbjct: 993  ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052

Query: 512  DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
            D LE+ KR+LE   G+L  AQE++   E  K +L  +L     E   L   +   +A  +
Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108

Query: 572  AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
              Q  ++E +A +       E +R+S+ + E Q     RE +E  + +RL          
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156

Query: 627  AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 683
               E AG    A  +++             L     +     +TL + HA  +  L    
Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
            D    V              I+  A++    +     L   CR    +  EL  + ++QQ
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 803
             L +       T  +G LQ       + LD  +E L + + +   A +  IE+  R++E+
Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327

Query: 804  MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
             +   N   HA    +        + C  L +       +   LQ+ + ++    A  + 
Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379

Query: 861  FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 911
             Y  ++ + TE L  A K +      A + VEA +       K ++ +    E     + 
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439

Query: 912  ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
             + A   A  K + N         Q+C  T  E  A+   +   G E  + ++  + S  
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

Query: 972  SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
             L  LK++    Q  + +L + +     R+ EL K
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%)

Query: 354  LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            +Q+E+  +EV       E + +EL   K + +   ++LK  ++ LE  L +  K+K    
Sbjct: 919  IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978

Query: 407  VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 462
               + L  E+A L     +  + +   +EA ++      A E + N L +   +L     
Sbjct: 979  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 463  EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 501
            +L         LR + + AK+     L + Q+S  ++   K+QL        F++  ++ 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098

Query: 502  ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 551
            + E           K++E   ++E+L+ E+EA+    A+A++  S   +   E+S RL+ 
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 552  LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 608
                  A     ++REA+    Q + R+ E A  + +  ++   ++  +    L E+   
Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215

Query: 609  EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 663
             Q ++Q+L  E+  +       A+ +  + VSK    L   C +  D L         Q+
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273

Query: 664  ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 718
             L    T + G  Q     +   L +  ALV+ L+R        I        L     A
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331

Query: 719  DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 776
               +    +      +L+ +  +++  +  +A L R   +   ++ Q       D   R 
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 777  EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 836
            EEL     K++A    A E+ V        +A +A      +  +R+ N   DLM  +  
Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440

Query: 837  LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 894
                  +L K+     +  A  ++   +     E     ++++G    ++  A ++ +  
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 895  LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
            L T K E   +   EI+  T Q+    K         +  L++  + V +    + A+ +
Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551

Query: 955  SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
              +  +E  +      +  I+L+  +++++V     EK  E ++++   +R
Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%)

Query: 419  LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
            L++A+ E E +  ++EE ++   + + +EA+  +L+EK   L+    +L  +    A+ L
Sbjct: 846  LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 476  TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
               ++  +++ + K QL  ++++V   +E              KLE++  +L+K   +LE
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
                ++ + + A  +  ++ +E  + LD     L+ EK AL  A +Q   DL A +  V 
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 579  E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 614
              T+A +  EQQ    E                    +G+L   Q  + + E+++Q L +
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 615  RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
            +L  ++F +             +  SK++D   L        L  + +E    +  LEE 
Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127

Query: 675  HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 733
                  S A A    + L+R     ++ +   GGATS       A   ++  RE      
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177

Query: 734  ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 784
            + M +  ++  L+H    A+L +     + +LG+++       + L+  + E+   +D  
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237

Query: 785  ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
                + ++     +E   R +ED +++ +      K E  +R++N   DL      L T 
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289

Query: 841  STSLQKEIVES---------GRGAATQQ 859
            S    +++ E          G+ A TQQ
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%)

Query: 391  LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 449
            L G LEE R  K   L+   Q R    +   A++E +R        ER+ +    +YN  
Sbjct: 775  LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825

Query: 450  --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 505
              +  KH   + +  ++  L K+A+T K++      +EE  ++K++LA + E  ++E E 
Sbjct: 826  SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881

Query: 506  KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
            K+     +   L+ +++A+A  LA A+E      ++K +L +++             V +
Sbjct: 882  KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930

Query: 566  READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
            R  D     + +   +  L  E     ++  +L+  LA+ E ++     +        ++
Sbjct: 931  RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982

Query: 626  GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 685
                E AG L + ++KL                ++ ++A      L+E H Q L  L   
Sbjct: 983  NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019

Query: 686  SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 745
               V  LT+                        ++ +D          +L G L+ ++ L
Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050

Query: 746  RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 805
            R M     +  L+G L+L QE     +D+  E+    +D+++      I +   +IED  
Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102

Query: 806  NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 865
                  + G++L+             K I+ L      L++EI       A  ++  +  
Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145

Query: 866  SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 925
            SR  E +    +  G GAT     + ++ ++  +  E      ++  +T Q  A +    
Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199

Query: 926  NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 985
             KH+  ++ L E    +      +       + +I+D      S +  +   K  +E   
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255

Query: 986  RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 1016
            R LE +    K+ E E+ RL  +L  Q   L   SG
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 416
            + L+ ++  ++ E+E I  EA+    + K  +      + E+ K++Q      E+++  +
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792

Query: 417  AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 471
             Q ++  QL  + ++ L  +  +K     EAR  +L+ +       +AE    LRK+   
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852

Query: 472  AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 523
             K+LT  T++ ++ + R++   ++L  +V+  KR++E + EE+S+    +  KL+ ELE 
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911

Query: 524  KAGELARAQEALSHTEQSKSELSSR 548
                 A  +  ++ ++ +K  + SR
Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%)

Query: 346  GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 403
            G V+ ++    E++K  R+ E    EL     E ++ I +L+  V+ L+ +++  ++Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889

Query: 404  KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +A    EQ    LA+ R  Q E        EEAE +A   E++ NKL+ K  E   VH +
Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936

Query: 464  LL 465
            ++
Sbjct: 1937 VI 1938



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%)

Query: 356  IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            +E   +++++   E E++ L+  ++ I +L+++V  LEGE+E ++K+  +A+    +   
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 415  ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 470
             + +L   Q E +R   LR ++   K  A    Y +  E+  E  + +    RK     +
Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910

Query: 471  TAKQLTVTQQSQEEVARVKEQ 491
             A++     +SQ    RVK +
Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 168/778 (21%), Positives = 321/778 (41%), Gaps = 132/778 (16%)

Query: 349  KDDRDLQIESLKREVEMLRSELEK---IKLEAQRYIAQLKSQVNALEGELEEQRKQKQKA 405
            K   D +++  + E+  L+S++E    + ++ Q+ I +L++++  LE E+E +R  + KA
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 406  LVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVH---- 461
                  L  EL ++     E   +   + E  +K    EA + K++    E    H    
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRRDLEEATLQHEATA 1195

Query: 462  AELLRKNADTAKQL--------TVTQQSQEEVARVK---EQLAFQVEQVKRE-------- 502
            A L +K+AD+  +L         V Q+ ++E + +K   + LA  VE V +         
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 503  -------SELKLEEKSDQ-----LEKLKRELEAKAGELARA---QEAL-SHTEQSKSELS 546
                   SELK +E+  Q     L   +  L+ ++GE +R    +EAL S   + K   +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 547  SRLDTLSAE-------KDALSGAVR--QREADLLAAQ-SLVRETEAALSRE--------- 587
             +++ L  +       K+AL+ A++  + + DLL  Q    +E++A L R          
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 588  QQRSSQEQGELQGRLAERESQEQGLRQRL--LDEQFAVLRGAAAEAAGILQDAVSKLDD- 644
            Q R+  E   +Q R  E E  ++ L QRL   +E    +    A      Q   ++++D 
Sbjct: 1376 QWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434

Query: 645  PLHLRCTSSPDYLVSRAQEALDAV-----STLEEGHAQYLTSLADASALVAALTRFSHLA 699
             L +  T++    + + Q   D +        EE HA+   S  +A +L   L +  +  
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494

Query: 700  ADTI--INGGATSHLAPTDPADRLIDTCRECGARA--------------LELMGQLQDQQ 743
             +++  +      +         L +   E G R                EL   L++ +
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554

Query: 744  A-LRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
            A L H +  ++R  L   Q   ++ +++  K  ++ Q         E + + +D E+ + 
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614

Query: 791  SAAI------EDAVRRIEDMMNQA-RHASSGVKLEVNER------------ILNSCTDLM 831
            + AI      E  +  +E  +N A R A+  ++   N +             L S  DL 
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674

Query: 832  KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAAD 891
            + + ++   +  LQ EI E     AT ++         + L+ AS+ V     QL+   +
Sbjct: 1675 EQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV-----QLLHTQN 1726

Query: 892  KVVLHTGKYEELIVCSHE-IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV 950
              +++T K  E  +   +       Q    ++ KA K     + + E  +   + +A++ 
Sbjct: 1727 TSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786

Query: 951  ASTKSGQEQIEDRDTM--DFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
               K+ ++ ++D      +   L+L   KKQ  + + RV ELE  +E+E+ R  E  K
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 147/695 (21%), Positives = 273/695 (39%), Gaps = 83/695 (11%)

Query: 348  VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            +K+  DLQ++        +++E E +    +R    +K+++     +LE + K+  +   
Sbjct: 887  LKEKNDLQLQ--------VQAEAEGLADAEERCDQLIKTKI-----QLEAKIKEVTERAE 933

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
            D E++  EL   +  +LE E S+  ++         + E++  ATE +   L E+ + L 
Sbjct: 934  DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992

Query: 459  HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
               A+L +  K    A Q T+     EE     + + K +L  QV+ ++   E + + + 
Sbjct: 993  ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052

Query: 512  DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
            D LE+ KR+LE   G+L  AQE++   E  K +L  +L     E   L   +   +A  +
Sbjct: 1053 D-LERAKRKLE---GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108

Query: 572  AAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRG 626
              Q  ++E +A +       E +R+S+ + E Q     RE +E  + +RL          
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERL---------- 1156

Query: 627  AAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA--- 683
               E AG    A  +++             L     +     +TL + HA  +  L    
Sbjct: 1157 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
            D    V              I+  A++    +     L   CR    +  EL  + ++QQ
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIED 803
             L +       T  +G LQ       + LD  +E L + + +   A +  IE+  R++E+
Sbjct: 1274 RLIN-----DLTAQRGRLQTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEE 1327

Query: 804  MM---NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQE 860
             +   N   HA    +        + C  L +       +   LQ+ + ++    A  + 
Sbjct: 1328 EIKAKNALAHALQSSR--------HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379

Query: 861  FYAKNS-RWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHE-----IA 911
             Y  ++ + TE L  A K +      A + VEA +       K ++ +    E     + 
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439

Query: 912  ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
             + A   A  K + N         Q+C  T  E  A+   +   G E  + ++  + S  
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

Query: 972  SLIKLKKQEMETQVRVLELEKTLEAERMRLGELRK 1006
             L  LK++    Q  + +L + +     R+ EL K
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 137/711 (19%), Positives = 282/711 (39%), Gaps = 90/711 (12%)

Query: 354  LQIESLKREV-------EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            +Q+E+  +EV       E + +EL   K + +   ++LK  ++ LE  L +  K+K    
Sbjct: 919  IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978

Query: 407  VDNEQLRHELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVHVHA 462
               + L  E+A L     +  + +   +EA ++      A E + N L +   +L     
Sbjct: 979  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 463  EL---------LRKNADTAKQ-----LTVTQQSQEEVARVKEQL-------AFQVEQVKR 501
            +L         LR + + AK+     L + Q+S  ++   K+QL        F++  ++ 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098

Query: 502  ESE----------LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDT 551
            + E           K++E   ++E+L+ E+EA+    A+A++  S   +   E+S RL+ 
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 552  LSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSS---QEQGELQGRLAERESQ 608
                  A     ++REA+    Q + R+ E A  + +  ++   ++  +    L E+   
Sbjct: 1159 AGGATSAQIEMNKKREAEF---QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215

Query: 609  EQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL-----VSRAQE 663
             Q ++Q+L  E+  +       A+ +  + VSK    L   C +  D L         Q+
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273

Query: 664  ALDAVSTLEEGHAQ-----YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPA 718
             L    T + G  Q     +   L +  ALV+ L+R        I        L     A
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE--LKRQLEEEIKA 1331

Query: 719  DRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDV--RQ 776
               +    +      +L+ +  +++  +  +A L R   +   ++ Q       D   R 
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEE--QESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 777  EELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRL 836
            EEL     K++A    A E+ V        +A +A      +  +R+ N   DLM  +  
Sbjct: 1390 EEL-EEAKKKLAQRLQAAEEHV--------EAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440

Query: 837  LVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV-- 894
                  +L K+     +  A  ++   +     E     ++++G    ++  A ++ +  
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 895  LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
            L T K E   +   EI+  T Q+    K         +  L++  + V +    + A+ +
Sbjct: 1501 LETLKRENKNL-QQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCELQAALE 1551

Query: 955  SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
              +  +E  +      +  I+L+  +++++V     EK  E ++++   +R
Sbjct: 1552 EAEASLEHEE----GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 107/508 (21%), Positives = 213/508 (41%), Gaps = 103/508 (20%)

Query: 419  LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
            L++A+ E E +  ++EE ++   + + +EA+  +L+EK   L+    +L  +    A+ L
Sbjct: 846  LKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 476  TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
               ++  +++ + K QL  ++++V   +E              KLE++  +L+K   +LE
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
                ++ + + A  +  ++ +E  + LD     L+ EK AL  A +Q   DL A +  V 
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 579  E-TEAALSREQQRSSQE--------------------QGEL---QGRLAERESQEQGLRQ 614
              T+A +  EQQ    E                    +G+L   Q  + + E+++Q L +
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 615  RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
            +L  ++F +             +  SK++D   L        L  + +E    +  LEE 
Sbjct: 1085 KLKKKEFEI------------SNLQSKIEDEQALGI-----QLQKKIKELQARIEELEEE 1127

Query: 675  HAQYLTSLADASALVAALTRFSHLAADTIIN-GGATSHLAPTDPADRLIDTCRECGARAL 733
                  S A A    + L+R     ++ +   GGATS       A   ++  RE      
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREA---EF 1177

Query: 734  ELMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD-- 784
            + M +  ++  L+H    A+L +     + +LG+++       + L+  + E+   +D  
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237

Query: 785  ----KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
                + ++     +E   R +ED +++ +      K E  +R++N   DL      L T 
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKS-----KEEEQQRLIN---DLTAQRGRLQTE 1289

Query: 841  STSLQKEIVES---------GRGAATQQ 859
            S    +++ E          G+ A TQQ
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 129/636 (20%), Positives = 247/636 (38%), Gaps = 129/636 (20%)

Query: 391  LEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNK- 449
            L G LEE R  K   L+   Q R    +   A++E +R        ER+ +    +YN  
Sbjct: 775  LLGLLEEMRDDKLAQLITRTQAR---CRGFLARVEYQRM------VERREAIFCIQYNIR 825

Query: 450  --LKEKHSELVHVHAEL--LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL 505
              +  KH   + +  ++  L K+A+T K++      +EE  ++K++LA + E  ++E E 
Sbjct: 826  SFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT---MKEEFQKIKDELA-KSEAKRKELEE 881

Query: 506  KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
            K+     +   L+ +++A+A  LA A+E      ++K +L +++             V +
Sbjct: 882  KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK-----------EVTE 930

Query: 566  READLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLR 625
            R  D     + +   +  L  E     ++  +L+  LA+ E ++     +        ++
Sbjct: 931  RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--------VK 982

Query: 626  GAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADA 685
                E AG L + ++KL                ++ ++A      L+E H Q L  L   
Sbjct: 983  NLTEEMAG-LDETIAKL----------------TKEKKA------LQEAHQQTLDDLQAE 1019

Query: 686  SALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQAL 745
               V  LT+                        ++ +D          +L G L+ ++ L
Sbjct: 1020 EDKVNTLTK-------------------AKIKLEQQVD----------DLEGSLEQEKKL 1050

Query: 746  RHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMM 805
            R M     +  L+G L+L QE     +D+  E+    +D+++      I +   +IED  
Sbjct: 1051 R-MDLERAKRKLEGDLKLAQE---SIMDIENEK--QQLDEKLKKKEFEISNLQSKIED-- 1102

Query: 806  NQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKN 865
                  + G++L+             K I+ L      L++EI       A  ++  +  
Sbjct: 1103 ----EQALGIQLQ-------------KKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145

Query: 866  SRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKA 925
            SR  E +    +  G GAT     + ++ ++  +  E      ++  +T Q  A +    
Sbjct: 1146 SRELEEISERLEEAG-GAT-----SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199

Query: 926  NKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV 985
             KH+  ++ L E    +      +       + +I+D      S +  +   K  +E   
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNVETVSKAKGNLEKMC 1255

Query: 986  RVLELE----KTLEAERMRL-GELRKQHYVLAGASG 1016
            R LE +    K+ E E+ RL  +L  Q   L   SG
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 47/205 (22%), Positives = 103/205 (50%), Gaps = 20/205 (9%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHEL 416
            + L+ ++  ++ E+E I  EA+    + K  +      + E+ K++Q      E+++  +
Sbjct: 1734 KKLETDISQMQGEMEDILQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNM 1792

Query: 417  AQ-LRAAQLEGERSQGLREEAERKA-SATEARYNKLKEKHSELVHVHAEL---LRKNADT 471
             Q ++  QL  + ++ L  +  +K     EAR  +L+ +       +AE    LRK+   
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852

Query: 472  AKQLTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSD----QLEKLKRELEA 523
             K+LT  T++ ++ + R++   ++L  +V+  KR++E + EE+S+    +  KL+ ELE 
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKFRKLQHELEE 1911

Query: 524  KAGELARAQEALSHTEQSKSELSSR 548
                 A  +  ++ ++ +K  + SR
Sbjct: 1912 -----AEERADIAESQVNKLRVKSR 1931



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 15/122 (12%)

Query: 346  GSVKDDRDLQIESLK--REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQ 403
            G V+ ++    E++K  R+ E    EL     E ++ I +L+  V+ L+ +++  ++Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889

Query: 404  KALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +A    EQ    LA+ R  Q E        EEAE +A   E++ NKL+ K  E   VH +
Sbjct: 1890 EA---EEQSNTNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSRE---VHTK 1936

Query: 464  LL 465
            ++
Sbjct: 1937 VI 1938



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 6/141 (4%)

Query: 356  IESLKREVEMLRSELEKIKLEA-QRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            +E   +++++   E E++ L+  ++ I +L+++V  LEGE+E ++K+  +A+    +   
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 415  ELAQLRAAQLEGERSQGLR-EEAERKASATEARYNKLKEKHSELVHVHAELLRK---NAD 470
             + +L   Q E +R   LR ++   K  A    Y +  E+  E  + +    RK     +
Sbjct: 1852 RVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910

Query: 471  TAKQLTVTQQSQEEVARVKEQ 491
             A++     +SQ    RVK +
Sbjct: 1911 EAEERADIAESQVNKLRVKSR 1931


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
            +DR  +  S   E E     L K++L+ +  IA ++ ++                L+GE 
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089

Query: 396  EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
             E ++Q  +     E+LR +L         A  RA    G R+Q L+   E +A+  EA+
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149

Query: 447  YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
             +   E+               EL  +  EL      T  Q  +  + ++EV  +K+ L 
Sbjct: 1150 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209

Query: 494  FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
             +       V+++++     L E ++QLE+ +R           LEA+  EL     +L 
Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1269

Query: 537  HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
                                       E++++E + +L    AE + +SGA+ + E+  +
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1329

Query: 572  AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
                 +  TEA L   Q   Q  ++ +  L  R+   E++  GLR++L +E       AA
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1383

Query: 629  AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
             E AG  LQ A ++L                 +    R     + L  R  E  + V  L
Sbjct: 1384 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443

Query: 672  EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
            E G  +    L DA+        LV+ L +      D ++     + L   +  +R    
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1502

Query: 725  CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
             RE  ARAL L   L+++Q  R     Q   +R  L+ +L    ++      V + E   
Sbjct: 1503 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1559

Query: 782  VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
             V ++ A    A    V  +ED +  A  A   ++LEV  + L   T   + ++      
Sbjct: 1560 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1612

Query: 842  TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
               ++++ +  R A  +++   K         +  EG +   KA    A Q  E A K +
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672

Query: 895  LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
                   + +    E   ++ + + +   ++ K    L    E  R   E AA+  A  +
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1730

Query: 955  SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
            + Q++ E  D +    LS   + +++ + + R+ +LE+ LE E+    EL    Y
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1784



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++ + K+E+E++ SELE                  A  GE EE  +Q Q    + ++L+ 
Sbjct: 937  RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 975

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
             + +L  A LE E  +G R++ + +   TEA+  K +E    L   +++L ++      +
Sbjct: 976  HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1032

Query: 475  LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
            L   + Q+ EE  +VK     +L ++      E  L+ EEK  Q LEKLKR L+ ++ EL
Sbjct: 1033 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1092

Query: 529  ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
               QE +   +Q   EL ++L     E  A                  +RE +AAL+  Q
Sbjct: 1093 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149

Query: 589  QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
            +    E      R+A  ++++Q   +R L E+   LRG      ++    Q+  SK +  
Sbjct: 1150 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1200

Query: 646  L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
            +  L+ T   +   +R  EA  AV  L + H Q L  LA+              TR +  
Sbjct: 1201 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255

Query: 699  AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
            A  + +    +S           + T R+ G    R LEL  QLQ+ Q  R       R 
Sbjct: 1256 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1301

Query: 756  PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
                 LQ  Q EL+  S  + + E   + + KE+++T A + DA   +++         S
Sbjct: 1302 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1361

Query: 814  GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
             V+        + E++        +A R L T    L    +++  E+G    G   ++ 
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1421

Query: 861  FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
               +    T+ L   ++ V     G  +L +  D   +   +  +L+    +      QL
Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
            +A  K    +      R +   R   ER A  ++ T++ +E+ E R+ ++         L
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1538

Query: 974  IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
              L   + +    V ELE+          +LR Q
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1572



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)

Query: 387  QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
            QV   +  L+ + ++ QK     +Q   E+ +L  R AQLE ER+   + LR EAE  A 
Sbjct: 871  QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 930

Query: 442  ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
            A E R  +L  +  EL  V +EL    A   ++   ++Q Q E  R+++ +        +
Sbjct: 931  AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 978

Query: 502  ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
            E E  LE +    +KL+ E      ++ + +E L   E   S+LS     L       S 
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 562  AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
               + E  + +   L  + EA ++      R++++  QE  +L+ RL     E QEQ + 
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
            Q+   E+     G   E    LQ A+++ +D
Sbjct: 1099 QQQRAEELRAQLGRKEEE---LQAALARAED 1126



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            ++R  Q+    R+ E+ R E  K     QR +A    +   LEGELEE + Q   A    
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1665

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E+   +L +++A   E      L  E E   ++ E  +++ +E    L  + AE+LR   
Sbjct: 1666 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
            + A      +Q+Q++    ++++A +V          LEE        KR+LE + G+L 
Sbjct: 1720 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1767

Query: 530  RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
               E     EQS SEL +        ++++L+ E  A      + E+     +  ++E  
Sbjct: 1768 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1823

Query: 582  AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
              L  E    + R       L+ +LA+ E Q EQ  R+R+L
Sbjct: 1824 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1864



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)

Query: 346  GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
            G  K++   Q+  ++ +++ L  E+E+ +           E+++ +  L+++V  L+ EL
Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721

Query: 396  EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
                + +++A  D +++  E+A     +AA      QLEG   Q L EE E + S +E  
Sbjct: 1722 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1780

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
             ++ ++   ++  +  EL  + + +AK  +  QQ + ++  ++ +L  +    +   ++ 
Sbjct: 1781 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1840

Query: 507  LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
            +     +L + + +LE +  E   + + +   E+   E+  +++      D L   + + 
Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1900

Query: 567  EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
               +   +  + E E   SR Q    + Q EL+      ES  +    LR RL
Sbjct: 1901 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
            E L  E    +L   RY  +L  QV +L  EL  +R    KA    +QL  ++ +LR   
Sbjct: 1768 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826

Query: 424  LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
              GE   G R   +   +A E++  + +E+  +      +  +L+R+     K++ +   
Sbjct: 1827 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1881

Query: 481  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
              EE  RV +QL  Q           LE+ + ++++LKR+LE    E +RAQ      ++
Sbjct: 1882 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930

Query: 541  SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
               +++   ++++ E   L   +R+          + + R  E   S E+   +Q
Sbjct: 1931 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
            +DR  +  S   E E     L K++L+ +  IA ++ ++                L+GE 
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081

Query: 396  EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
             E ++Q  +     E+LR +L         A  RA    G R+Q L+   E +A+  EA+
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141

Query: 447  YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
             +   E+               EL  +  EL      T  Q  +  + ++EV  +K+ L 
Sbjct: 1142 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201

Query: 494  FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
             +       V+++++     L E ++QLE+ +R           LEA+  EL     +L 
Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1261

Query: 537  HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
                                       E++++E + +L    AE + +SGA+ + E+  +
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1321

Query: 572  AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
                 +  TEA L   Q   Q  ++ +  L  R+   E++  GLR++L +E       AA
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1375

Query: 629  AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
             E AG  LQ A ++L                 +    R     + L  R  E  + V  L
Sbjct: 1376 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435

Query: 672  EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
            E G  +    L DA+        LV+ L +      D ++     + L   +  +R    
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1494

Query: 725  CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
             RE  ARAL L   L+++Q  R     Q   +R  L+ +L    ++      V + E   
Sbjct: 1495 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1551

Query: 782  VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
             V ++ A    A    V  +ED +  A  A   ++LEV  + L   T   + ++      
Sbjct: 1552 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1604

Query: 842  TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
               ++++ +  R A  +++   K         +  EG +   KA    A Q  E A K +
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664

Query: 895  LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
                   + +    E   ++ + + +   ++ K    L    E  R   E AA+  A  +
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1722

Query: 955  SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
            + Q++ E  D +    LS   + +++ + + R+ +LE+ LE E+    EL    Y
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1776



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++ + K+E+E++ SELE                  A  GE EE  +Q Q    + ++L+ 
Sbjct: 929  RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 967

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
             + +L  A LE E  +G R++ + +   TEA+  K +E    L   +++L ++      +
Sbjct: 968  HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1024

Query: 475  LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
            L   + Q+ EE  +VK     +L ++      E  L+ EEK  Q LEKLKR L+ ++ EL
Sbjct: 1025 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1084

Query: 529  ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
               QE +   +Q   EL ++L     E  A                  +RE +AAL+  Q
Sbjct: 1085 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141

Query: 589  QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
            +    E      R+A  ++++Q   +R L E+   LRG      ++    Q+  SK +  
Sbjct: 1142 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1192

Query: 646  L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
            +  L+ T   +   +R  EA  AV  L + H Q L  LA+              TR +  
Sbjct: 1193 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247

Query: 699  AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
            A  + +    +S           + T R+ G    R LEL  QLQ+ Q  R       R 
Sbjct: 1248 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1293

Query: 756  PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
                 LQ  Q EL+  S  + + E   + + KE+++T A + DA   +++         S
Sbjct: 1294 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1353

Query: 814  GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
             V+        + E++        +A R L T    L    +++  E+G    G   ++ 
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1413

Query: 861  FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
               +    T+ L   ++ V     G  +L +  D   +   +  +L+    +      QL
Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
            +A  K    +      R +   R   ER A  ++ T++ +E+ E R+ ++         L
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1530

Query: 974  IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
              L   + +    V ELE+          +LR Q
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1564



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)

Query: 387  QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
            QV   +  L+ + ++ QK     +Q   E+ +L  R AQLE ER+   + LR EAE  A 
Sbjct: 863  QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 922

Query: 442  ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
            A E R  +L  +  EL  V +EL    A   ++   ++Q Q E  R+++ +        +
Sbjct: 923  AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 970

Query: 502  ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
            E E  LE +    +KL+ E      ++ + +E L   E   S+LS     L       S 
Sbjct: 971  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030

Query: 562  AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
               + E  + +   L  + EA ++      R++++  QE  +L+ RL     E QEQ + 
Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1090

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
            Q+   E+     G   E    LQ A+++ +D
Sbjct: 1091 QQQRAEELRAQLGRKEEE---LQAALARAED 1118



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            ++R  Q+    R+ E+ R E  K     QR +A    +   LEGELEE + Q   A    
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1657

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E+   +L +++A   E      L  E E   ++ E  +++ +E    L  + AE+LR   
Sbjct: 1658 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
            + A      +Q+Q++    ++++A +V          LEE        KR+LE + G+L 
Sbjct: 1712 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1759

Query: 530  RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
               E     EQS SEL +        ++++L+ E  A      + E+     +  ++E  
Sbjct: 1760 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1815

Query: 582  AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
              L  E    + R       L+ +LA+ E Q EQ  R+R+L
Sbjct: 1816 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1856



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)

Query: 346  GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
            G  K++   Q+  ++ +++ L  E+E+ +           E+++ +  L+++V  L+ EL
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713

Query: 396  EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
                + +++A  D +++  E+A     +AA      QLEG   Q L EE E + S +E  
Sbjct: 1714 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1772

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
             ++ ++   ++  +  EL  + + +AK  +  QQ + ++  ++ +L  +    +   ++ 
Sbjct: 1773 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1832

Query: 507  LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
            +     +L + + +LE +  E   + + +   E+   E+  +++      D L   + + 
Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1892

Query: 567  EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
               +   +  + E E   SR Q    + Q EL+      ES  +    LR RL
Sbjct: 1893 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
            E L  E    +L   RY  +L  QV +L  EL  +R    KA    +QL  ++ +LR   
Sbjct: 1760 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818

Query: 424  LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
              GE   G R   +   +A E++  + +E+  +      +  +L+R+     K++ +   
Sbjct: 1819 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1873

Query: 481  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
              EE  RV +QL  Q           LE+ + ++++LKR+LE    E +RAQ      ++
Sbjct: 1874 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922

Query: 541  SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
               +++   ++++ E   L   +R+          + + R  E   S E+   +Q
Sbjct: 1923 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 167/775 (21%), Positives = 300/775 (38%), Gaps = 135/775 (17%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNA--------------LEGEL 395
            +DR  +  S   E E     L K++L+ +  IA ++ ++                L+GE 
Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1122

Query: 396  EEQRKQKQKALVDNEQLRHEL---------AQLRAAQLEGERSQGLREEAERKASATEAR 446
             E ++Q  +     E+LR +L         A  RA    G R+Q L+   E +A+  EA+
Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182

Query: 447  YNKLKEK-------------HSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLA 493
             +   E+               EL  +  EL      T  Q  +  + ++EV  +K+ L 
Sbjct: 1183 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242

Query: 494  FQ-------VEQVKRESELKLEEKSDQLEKLKR----------ELEAKAGELARAQEALS 536
             +       V+++++     L E ++QLE+ +R           LEA+  EL     +L 
Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1302

Query: 537  HT-------------------------EQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
                                       E++++E + +L    AE + +SGA+ + E+  +
Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI 1362

Query: 572  AAQSLVRETEAALSREQ---QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAA 628
                 +  TEA L   Q   Q  ++ +  L  R+   E++  GLR++L +E       AA
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------AAA 1416

Query: 629  AEAAG-ILQDAVSKLD----------------DPLHLRCTSSPDYLVSRAQEALDAVSTL 671
             E AG  LQ A ++L                 +    R     + L  R  E  + V  L
Sbjct: 1417 RERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476

Query: 672  EEGHAQYLTSLADAS-------ALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDT 724
            E G  +    L DA+        LV+ L +      D ++     + L   +  +R    
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEK-KQRKFDQLLAEEKAAVLRAVEERERAEAE 1535

Query: 725  CRECGARALELMGQLQDQQALR---HMQASLVRTPLQGILQLGQELKPKSLDVRQEELGA 781
             RE  ARAL L   L+++Q  R     Q   +R  L+ +L    ++      V + E   
Sbjct: 1536 GREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV---GKSVHELERAC 1592

Query: 782  VVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
             V ++ A    A    V  +ED +  A  A   ++LEV  + L   T   + ++      
Sbjct: 1593 RVAEQAANDLRA---QVTELEDELTAAEDAK--LRLEVTVQALK--TQHERDLQGRDEAG 1645

Query: 842  TSLQKEIVESGRGAATQQEFYAKN-------SRWTEGLISASKAVGWGATQLVEAADKVV 894
               ++++ +  R A  +++   K         +  EG +   KA    A Q  E A K +
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1705

Query: 895  LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTK 954
                   + +    E   ++ + + +   ++ K    L    E  R   E AA+  A  +
Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE--AEVLRLQEELAASDRARRQ 1763

Query: 955  SGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
            + Q++ E  D +    LS   + +++ + + R+ +LE+ LE E+    EL    Y
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELLNDRY 1817



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 161/694 (23%), Positives = 280/694 (40%), Gaps = 99/694 (14%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++ + K+E+E++ SELE                  A  GE EE  +Q Q    + ++L+ 
Sbjct: 970  RLAARKQELELVVSELE------------------ARVGEEEECSRQMQ---TEKKRLQQ 1008

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
             + +L  A LE E  +G R++ + +   TEA+  K +E    L   +++L ++      +
Sbjct: 1009 HIQELE-AHLEAE--EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR 1065

Query: 475  LT-VTQQSQEEVARVKE----QLAFQVEQVKRESELKLEEKSDQ-LEKLKRELEAKAGEL 528
            L   + Q+ EE  +VK     +L ++      E  L+ EEK  Q LEKLKR L+ ++ EL
Sbjct: 1066 LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1125

Query: 529  ARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQ 588
               QE +   +Q   EL ++L     E  A                  +RE +AAL+  Q
Sbjct: 1126 ---QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182

Query: 589  QRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA---AAEAAGILQDAVSKLDDP 645
            +    E      R+A  ++++Q   +R L E+   LRG      ++    Q+  SK +  
Sbjct: 1183 EDLESE------RVARTKAEKQ---RRDLGEELEALRGELEDTLDSTNAQQELRSKREQE 1233

Query: 646  L-HLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVA------ALTRFSHL 698
            +  L+ T   +   +R  EA  AV  L + H Q L  LA+              TR +  
Sbjct: 1234 VTELKKTLEEE---TRIHEA--AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288

Query: 699  AADTIINGGATSHLAPTDPADRLIDTCRECG---ARALELMGQLQDQQALRHMQASLVRT 755
            A  + +    +S           + T R+ G    R LEL  QLQ+ Q  R       R 
Sbjct: 1289 AEVSELRAELSS-----------LQTARQEGEQRRRRLEL--QLQEVQG-RAGDGERARA 1334

Query: 756  PLQGILQLGQ-ELKPKSLDVRQEELGAV-VDKEMAATSAAIEDAVRRIEDMMNQARHASS 813
                 LQ  Q EL+  S  + + E   + + KE+++T A + DA   +++         S
Sbjct: 1335 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1394

Query: 814  GVK------LEVNERILNSCTDLMKAIRLLVTTSTSL----QKEIVESG---RGAATQQE 860
             V+        + E++        +A R L T    L    +++  E+G    G   ++ 
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1454

Query: 861  FYAKNSRWTEGLISASKAVG---WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQL 917
               +    T+ L   ++ V     G  +L +  D   +   +  +L+    +      QL
Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSG----LSL 973
            +A  K    +      R +   R   ER A  ++ T++ +E+ E R+ ++         L
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGR---EREARALSLTRALEEEQEAREELERQNRALRAEL 1571

Query: 974  IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
              L   + +    V ELE+          +LR Q
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1605



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/271 (26%), Positives = 121/271 (44%), Gaps = 28/271 (10%)

Query: 387  QVNALEGELEEQRKQKQKALVDNEQLRHELAQL--RAAQLEGERS---QGLREEAERKAS 441
            QV   +  L+ + ++ QK     +Q   E+ +L  R AQLE ER+   + LR EAE  A 
Sbjct: 904  QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 963

Query: 442  ATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKR 501
            A E R  +L  +  EL  V +EL    A   ++   ++Q Q E  R+++ +        +
Sbjct: 964  AEETR-GRLAARKQELELVVSEL---EARVGEEEECSRQMQTEKKRLQQHI--------Q 1011

Query: 502  ESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG 561
            E E  LE +    +KL+ E      ++ + +E L   E   S+LS     L       S 
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071

Query: 562  AVRQREADLLAAQSLVRETEAALS------REQQRSSQEQGELQGRL--AERESQEQGLR 613
               + E  + +   L  + EA ++      R++++  QE  +L+ RL     E QEQ + 
Sbjct: 1072 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1131

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
            Q+   E+     G   E    LQ A+++ +D
Sbjct: 1132 QQQRAEELRAQLGRKEEE---LQAALARAED 1159



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            ++R  Q+    R+ E+ R E  K     QR +A    +   LEGELEE + Q   A    
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERK-----QRTLAVAARK--KLEGELEELKAQMASAGQGK 1698

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E+   +L +++A   E      L  E E   ++ E  +++ +E    L  + AE+LR   
Sbjct: 1699 EEAVKQLRKMQAQMKE------LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELA 529
            + A      +Q+Q++    ++++A +V          LEE        KR+LE + G+L 
Sbjct: 1753 ELAASDRARRQAQQD----RDEMADEVANGNLSKAAILEE--------KRQLEGRLGQLE 1800

Query: 530  RAQEALSHTEQSKSELSS--------RLDTLSAEKDALSGAVRQREADLLAAQSLVRETE 581
               E     EQS SEL +        ++++L+ E  A      + E+     +  ++E  
Sbjct: 1801 EELE----EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1856

Query: 582  AALSRE----QQRSSQEQGELQGRLAERESQ-EQGLRQRLL 617
              L  E    + R       L+ +LA+ E Q EQ  R+R+L
Sbjct: 1857 GRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1897



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 58/293 (19%), Positives = 131/293 (44%), Gaps = 23/293 (7%)

Query: 346  GSVKDDRDLQIESLKREVEMLRSELEKIKL----------EAQRYIAQLKSQVNALEGEL 395
            G  K++   Q+  ++ +++ L  E+E+ +           E+++ +  L+++V  L+ EL
Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1754

Query: 396  EEQRKQKQKALVDNEQLRHELAQ---LRAA------QLEGERSQGLREEAERKASATEAR 446
                + +++A  D +++  E+A     +AA      QLEG   Q L EE E + S +E  
Sbjct: 1755 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ-LEEELEEEQSNSELL 1813

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELK 506
             ++ ++   ++  +  EL  + + +AK  +  QQ + ++  ++ +L  +    +   ++ 
Sbjct: 1814 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1873

Query: 507  LEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR 566
            +     +L + + +LE +  E   + + +   E+   E+  +++      D L   + + 
Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKG 1933

Query: 567  EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQ---GLRQRL 616
               +   +  + E E   SR Q    + Q EL+      ES  +    LR RL
Sbjct: 1934 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 22/235 (9%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQ 423
            E L  E    +L   RY  +L  QV +L  EL  +R    KA    +QL  ++ +LR   
Sbjct: 1801 EELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859

Query: 424  LEGERSQGLREEAERKASATEARYNKLKEKHSELVH---VHAELLRKNADTAKQLTVTQQ 480
              GE   G R   +   +A E++  + +E+  +      +  +L+R+     K++ +   
Sbjct: 1860 --GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVL--- 1914

Query: 481  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ 540
              EE  RV +QL  Q           LE+ + ++++LKR+LE    E +RAQ      ++
Sbjct: 1915 QVEEERRVADQLRDQ-----------LEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963

Query: 541  SKSELSSRLDTLSAEKDALSGAVRQREADLL--AAQSLVRETEAALSREQQRSSQ 593
               +++   ++++ E   L   +R+          + + R  E   S E+   +Q
Sbjct: 1964 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 157/718 (21%), Positives = 295/718 (41%), Gaps = 117/718 (16%)

Query: 355  QIE-SLKREVEML--RSELEKIKLEAQRYIAQLKSQVNALEGELEEQ----RKQKQKALV 407
            QIE + KRE E L  R +LE+  L+ +  +A L+ +      EL EQ    ++ KQK   
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLREEA----ERKASATEARYNKLKEKHSELVHVHAE 463
            +  + + E+  L ++     +S+   E+     E + S    +  +++   SEL    + 
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEA 523
            L  +  + ++QL   +    +++R K+    Q E++KR+    LEE++     L   L++
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ----LEEENKAKNALAHALQS 1336

Query: 524  KAGELARAQEALSHTEQSKSELSSRLDTLSAE---------KDALSGAVRQREADLLAAQ 574
               +    +E     ++ K+EL   L   ++E          DA+       EA    AQ
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396

Query: 575  SLVRETE---------AALSREQQRSSQEQGELQGRLAERESQEQGL--RQRLLDEQFAV 623
             L    E         A+L + +QR   E  +L   +    S    L  +QR  D+  A 
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRA-QEALDAVSTLEEGHAQYLTSL 682
             +    E+   L+ ++ +       R  S+  + +  A +EALD + T++  +      +
Sbjct: 1457 WKTKCEESQAELEASLKES------RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510

Query: 683  ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ 742
            AD +  +A                G T H    + + + I+  +     ALE     + +
Sbjct: 1511 ADLTEQIA--------------ENGKTIH--ELEKSRKQIELEKADIQLALE-----EAE 1549

Query: 743  QALRHMQASLVRTPL---QGILQLGQELKPKSLDVRQ---------EELGAVVDKEMAAT 790
             AL H +A ++R  L   Q   ++ +++  K  ++ Q         E + + +D E+ + 
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609

Query: 791  SAAI------EDAVRRIEDMMNQA-RHASSGVK-------------LEVNERILNSCTDL 830
            + AI      E  +  IE  ++ A R A+  +K             L +++  L    DL
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA-LRGQEDL 1668

Query: 831  MKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAA 890
             + + ++   +  LQ E VE  R    Q E   K +   + L+ +++ V     QL+   
Sbjct: 1669 KEQLAIVERRANLLQAE-VEELRATLEQTERARKLAE--QELLDSNERV-----QLLHTQ 1720

Query: 891  DKVVLHTGKYEE--LIVCSHEIA-ASTAQLVAASKVK-----ANKHSPHLSRLQECSRTV 942
            +  ++HT K  E  L+    E+  AS     A  K K     A   +  L + Q+ S  +
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780

Query: 943  NERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMR 1000
                 N+  + K  Q ++++ + +   G      KKQ  + + R+ ELE  LE E+ +
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGG-----KKQIQKLETRIRELEFELEGEQKK 1833



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 80/291 (27%), Positives = 134/291 (46%), Gaps = 43/291 (14%)

Query: 348  VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            V++  DLQ++        +++E E + L+A+    QL      LE +++E  ++ +    
Sbjct: 882  VQEKNDLQLQ--------VQAESENL-LDAEERCDQLIKAKFQLEAKIKEVTERAE---- 928

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLRE---------EAERKASATEARYNKLKEKHSELV 458
            D E++  EL   +  +LE E S+  ++         + E++  ATE +   L E+ S L 
Sbjct: 929  DEEEINAELTA-KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD 987

Query: 459  HVHAELLR--KNADTAKQLTVTQQSQEE-----VARVKEQLAFQVEQVKRESELKLEEKS 511
               A+L R  K    A Q  +     EE     + + K +L  QVE +  ES L+ E+K 
Sbjct: 988  ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDL--ESSLEQEKKL 1045

Query: 512  D-QLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADL 570
               LE+ KR+LE   G+L  AQE++   E  K +L  RL     E   L   V   +   
Sbjct: 1046 RVDLERNKRKLE---GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102

Query: 571  LAAQSLVRETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRL 616
            L  Q  ++E +A +       E +R+++ + E Q     RE +E  L +RL
Sbjct: 1103 LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE--LSERL 1151



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 116/545 (21%), Positives = 224/545 (41%), Gaps = 96/545 (17%)

Query: 419  LRAAQLEGERSQGLREEAER---KASATEARYNKLKEKHSELVHVHAELLRKNADTAKQL 475
            L++A+ E E +  ++EE ++   + + +EA+  +L+EK   LV    +L  +    ++ L
Sbjct: 841  LKSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL 899

Query: 476  TVTQQSQEEVARVKEQLAFQVEQVKRESE-------------LKLEEKSDQLEKLKRELE 522
               ++  +++ + K QL  ++++V   +E              KLE++  +L+K   +LE
Sbjct: 900  LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLD----TLSAEKDALSGAVRQREADLLAAQSLVR 578
                ++ + + A  +  ++ +E  S LD     L+ EK AL  A +Q   DL A +  V 
Sbjct: 960  LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019

Query: 579  ETEAALSREQQR-----SSQEQ----------------GEL---QGRLAERESQEQGLRQ 614
                  S+ +Q+     SS EQ                G+L   Q  + + E+ +Q L +
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079

Query: 615  RLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEG 674
            RL  + F   +         LQ  V   +  L L+       L +R +E  + +      
Sbjct: 1080 RLKKKDFEYCQ---------LQSKVED-EQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129

Query: 675  HAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALE 734
             A+     +D +  +  L+     A      GG TS           I+  ++  A  L+
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEA------GGVTS---------TQIELNKKREAEFLK 1174

Query: 735  LMGQLQDQQALRH--MQASLVRTPLQGILQLGQELK-----PKSLDVRQEELGAVVD--- 784
            L   L ++  L+H  M A+L +     + +LG+++       + L+  + E    +D   
Sbjct: 1175 LRRDL-EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233

Query: 785  ---KEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTS 841
               + ++ + A +E   R +ED +++AR          NE I  S ++L      L T +
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGK--------NEEIQRSLSELTTQKSRLQTEA 1285

Query: 842  TSLQKEIVES----GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHT 897
              L +++ E      + + ++Q F  +       L   +KA    A  L  +     L  
Sbjct: 1286 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345

Query: 898  GKYEE 902
             +YEE
Sbjct: 1346 EQYEE 1350



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 129/689 (18%), Positives = 264/689 (38%), Gaps = 65/689 (9%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++     + E + +EL   K + +   ++LK  ++ LE  L +  K+K       + L  
Sbjct: 922  EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 981

Query: 415  ELAQLRAAQLEGERSQGLREEAERKA----SATEARYNKLKEKHSELVH----------- 459
            EL+ L     +  R +   +EA ++A     A E + N L +  S+L             
Sbjct: 982  ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041

Query: 460  ---VHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE---------QVKRESEL-- 505
               +  +L R        L + Q+S  ++   K+QL  +++         Q K E E   
Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101

Query: 506  ------KLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL 559
                  K++E   ++E+L+ E+EA+    A+ ++  S   +   ELS RL+         
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161

Query: 560  SGAVRQREADLLAAQSLVRETEAALSREQQRSS--QEQGELQGRLAERESQEQGLRQRLL 617
                ++REA+ L  +  +   EA L  E   ++  ++  +    L E+    Q ++Q+L 
Sbjct: 1162 IELNKKREAEFLKLRRDLE--EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219

Query: 618  DEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQ 677
             E+         +      ++VSK    L   C +  D L     +  +   +L E   Q
Sbjct: 1220 KEKSEF--KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQ 1277

Query: 678  YLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMG 737
                  +A  L   L        ++I++  + S  A T   + L     E       L  
Sbjct: 1278 KSRLQTEAGELSRQLEE-----KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332

Query: 738  QLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVD--KEMAATSAAIE 795
             LQ  +    +         +G  +L + L   + +V Q       D  +       A +
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392

Query: 796  DAVRRIEDMMNQ--ARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGR 853
               +R++D   Q  A +A      +  +R+     DLM  +    + + +L K+     +
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452

Query: 854  GAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVV--LHTGKYEELIVCSHEIA 911
              A  +    ++    E  +  S+++     +L  A ++ +  L T K E   +   EIA
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL-EQEIA 1511

Query: 912  ASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL 971
              T Q+    K         +  L++  + +    A++  + +  +  +E  +    + +
Sbjct: 1512 DLTEQIAENGKT--------IHELEKSRKQIELEKADIQLALEEAEAALEHEE----AKI 1559

Query: 972  SLIKLKKQEMETQVRVLELEKTLEAERMR 1000
              I+L+  ++++++     EK  E E+++
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLK 1588



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 43/198 (21%), Positives = 91/198 (45%), Gaps = 18/198 (9%)

Query: 355  QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
            ++E   R+      + +K   +A     +LK + +     LE  +K  ++ + D   L+H
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNLEQTVKD---LQH 1796

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
             L +     L+G + Q   ++ E +    E      ++K++E V    + LRK     K+
Sbjct: 1797 RLDEAEQLALKGGKKQ--IQKLETRIRELEFELEGEQKKNTESV----KGLRKYERRVKE 1850

Query: 475  LTV-TQQSQEEVARVK---EQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELAR 530
            LT  +++ ++ V R++   ++L  +V+  KR++E   E+ +  L K ++       EL  
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH----ELEE 1906

Query: 531  AQEALSHTEQSKSELSSR 548
            A+E     E   ++L ++
Sbjct: 1907 AEERADIAESQVNKLRAK 1924



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 6/51 (11%)

Query: 957  QEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQ 1007
            Q ++ED  T+       ++ +K+  E Q R+ ELE+ +EAER    +  KQ
Sbjct: 1092 QSKVEDEQTLG------LQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 1006 KQ 1007
             Q
Sbjct: 2224 SQ 2225



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1879 RLEEQAAQH 1887



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 897  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 957  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1580

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1581 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1635

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1688

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1689 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1742

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1743 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1792

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1793 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1834

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1895 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 2011 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2056

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2084



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2028

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2329 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2383

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2384 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2436

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2437 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2555 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2608

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2609 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2651



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1711 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1769 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1826

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1887 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2061

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2173

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2294 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2345

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1658

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1719 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1836 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1886

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1941

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 2002 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2118

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2119 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227

Query: 1006 KQ 1007
             Q
Sbjct: 2228 SQ 2229



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1517

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1518 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1200 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1320 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1380 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1557

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1616

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1617 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1659

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1837 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1882

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1883 RLEEQAAQH 1891



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2298 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2357 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2471

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2579

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2580 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2628

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2629 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1154

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1155 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1272 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1331

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1389

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1390 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1565

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1566 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1685 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1734

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 901  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 960

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 961  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1136

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1249

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1309

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1481

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1540

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQ 1568


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1576

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1577 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1631

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1684

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1685 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1738

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1739 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1788

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1789 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1830

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1891 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 2007 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2052

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2080



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2024

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2325 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2432

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2433 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2551 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2604

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2605 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2647



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1707 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1765 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1822

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1883 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2057

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2169

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2290 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2341

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1654

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1832 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1882

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1937

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 1998 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2114

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2115 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 1006 KQ 1007
             Q
Sbjct: 2224 SQ 2225



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1513

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1514 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1196 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1376 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1553

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1612

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1613 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1655

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1833 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1878

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1879 RLEEQAAQH 1887



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2294 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2353 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2467

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2575

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2576 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2624

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1150

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1151 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1385

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1386 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1561

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1562 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1681 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1730

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 897  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 957  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1132

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1245

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1477

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1536

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQ 1564


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1544

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1545 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1599

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1652

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1653 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1706

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1707 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1756

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1757 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1798

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1859 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 1975 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2020

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2048



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 1992

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2293 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2347

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2348 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2400

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2401 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2519 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2572

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2573 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2615



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1675 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1733 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1790

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1851 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2025

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2137

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2258 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2309

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1622

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1683 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1800 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1850

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1905

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 1966 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2082

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2083 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191

Query: 1006 KQ 1007
             Q
Sbjct: 2192 SQ 2193



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1481

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1482 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1164 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1284 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1344 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1521

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1580

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1581 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1623

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1801 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1846

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1847 RLEEQAAQH 1855



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2262 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2321 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2435

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2543

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2544 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2592

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2593 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1061 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1118

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1119 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1236 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1295

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1353

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1354 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1529

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1530 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1649 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1698

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 865  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 924

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 925  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 982  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1100

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1213

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1273

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1445

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1504

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQ 1532


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1713

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1714 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1768

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1821

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1822 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1875

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1876 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1925

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1926 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1967

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 2028 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 2144 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2189

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2217



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2161

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2462 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2516

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2517 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2569

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2570 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2688 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2741

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2742 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2784



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1844 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1902 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1959

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 2020 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2194

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2306

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2427 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2478

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1791

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1852 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1969 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 2019

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 2074

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 2135 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2251

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2252 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360

Query: 1006 KQ 1007
             Q
Sbjct: 2361 SQ 2362



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1650

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1651 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1333 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1453 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1513 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1690

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1749

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1750 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1792

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1970 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 2015

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 2016 RLEEQAAQH 2024



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2431 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2490 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2604

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2712

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2713 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2761

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2762 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1230 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1287

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1288 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1405 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1464

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1522

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1523 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1698

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1699 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1818 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1867

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 1093

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 1094 E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1269

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1382

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1442

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1614

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1673

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQ 1701


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1554

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1555 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1609

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1662

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1663 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1716

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1717 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1766

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1767 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1808

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1869 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 1985 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2030

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2058



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2002

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2303 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2357

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2358 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2410

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2411 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2529 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2582

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2583 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2625



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1685 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1743 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1800

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1861 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2035

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2147

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2268 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2319

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1632

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1693 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1810 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1860

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1915

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 1976 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2092

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2093 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201

Query: 1006 KQ 1007
             Q
Sbjct: 2202 SQ 2203



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1491

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1492 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1174 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1234 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1294 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1354 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1531

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1590

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1591 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1633

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1811 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1856

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1857 RLEEQAAQH 1865



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2272 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2331 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2445

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2553

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2554 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2602

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2603 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1071 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1128

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1129 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1246 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1305

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1363

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1364 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1539

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1540 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1659 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1708

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 875  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 935  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 992  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1110

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1223

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1224 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1283

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1455

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1514

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQ 1542


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1562

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1563 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1617

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1670

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1671 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1724

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1725 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1774

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1775 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1816

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1877 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 1993 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2038

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2066



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2010

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2311 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2365

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2366 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2418

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2419 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2537 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2590

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2591 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2633



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1693 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1751 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1808

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1869 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2043

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2155

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2276 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2327

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1640

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1701 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1818 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1868

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1923

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 1984 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2100

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2101 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209

Query: 1006 KQ 1007
             Q
Sbjct: 2210 SQ 2211



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1499

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1500 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1182 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1241

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1242 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1302 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1362 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1539

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1598

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1599 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1641

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1819 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1864

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1865 RLEEQAAQH 1873



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2280 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2339 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2453

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2561

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2562 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2610

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2611 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1079 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1136

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1137 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1254 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1313

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1371

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1372 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1547

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1548 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1667 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1716

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 883  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 942

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 943  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 999

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1118

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1231

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1232 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1291

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1463

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1522

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQ 1550


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 170/688 (24%), Positives = 284/688 (41%), Gaps = 102/688 (14%)

Query: 354  LQIESLKR-------EVEMLRS---ELEKIKLEAQRYIAQLKSQV-----NALEGELE-- 396
            LQ+E+ +R       E++ LR+   E E  K +AQ    +L+ QV        + E+E  
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545

Query: 397  -------EQRKQKQKALVDNEQLR--HELAQLRAAQLEGERSQGLREEAERKASATEARY 447
                   E  ++KQ+AL   E+LR   E A+ R  Q E ER++ ++   E    + EA  
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-- 1603

Query: 448  NKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKL 507
             +L+ K +      A+L R   +  + + V Q  +E   R ++Q   + E+ + E+E +L
Sbjct: 1604 -ELQSKRASFAEKTAQLERSLQE--EHVAVAQLREEAERRAQQQA--EAERAREEAEREL 1658

Query: 508  EE---KSDQLEKLKRELEAKAGELARAQ-EALSHTEQSKSELSSRLDTLSAEKDALSGAV 563
            E    K+++  +L+ + E  A + + AQ EA    E+++ E   R         A   AV
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAV 1711

Query: 564  RQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAV 623
            RQRE   LA Q L ++ + A    QQR + EQ EL    AE E  EQ  +++LL+E+ A 
Sbjct: 1712 RQRE---LAEQELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQ--QRQLLEEELAR 1765

Query: 624  LRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLA 683
            L+  AA A    Q+    L+  L          L S+A+   ++ ST E+   +      
Sbjct: 1766 LQREAAAATQKRQE----LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR------ 1815

Query: 684  DASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQ 743
                L A   RF  LA +      A    A  + A R      E  AR        Q  +
Sbjct: 1816 ----LEAEAGRFRELAEE------AARLRALAEEAKRQRQLAEEDAAR--------QRAE 1857

Query: 744  ALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR--- 800
            A R +   L        L+   E+  K  +   E L  + + E        E A +    
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917

Query: 801  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG-AATQQ 859
            IE+ + Q R AS   +LE  + ++    D ++  R +     +L+    ++  G A  + 
Sbjct: 1918 IEERLAQLRKASDS-ELERQKGLVE---DTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973

Query: 860  EFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEEL--IVCSHEIAASTAQL 917
            E     S   + L S  +A    A Q   AA++        E +   + + E AA   + 
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033

Query: 918  VAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLK 977
                  +         RL+E  R   E A  +  + ++ Q++++  +            K
Sbjct: 2034 ALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEE------------K 2079

Query: 978  KQEMETQVRVLELEKTLEAERMRLGELR 1005
                  Q +  EL++TL+ E+  L +LR
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLR 2107



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 96/768 (12%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +D   Q   ++ E+  L++  EK    A    A+L+ ++  +    E+  + K++A ++ 
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEK----AAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996

Query: 410  EQLRHELAQLRAAQLEGE----RSQGLREEAERKASATEARYNKLKEKHSELVHVHAELL 465
             + R   A+    + E E    +S    EEA R+  A      +LK K  E     A  L
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRL 2051

Query: 466  RKNAD--TAKQLTVTQQSQEEVARVKEQL-AFQVEQVKRESELKLEEKSDQLEKLKRELE 522
            R+ A+  +A+QL + Q++ ++  + +E+  AF V+Q ++E +  L+++   L++L+ E E
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111

Query: 523  AKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA 582
            A       A+EA    E+  ++   +++     K +     + R     AA+ L +E E 
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 583  ALSREQQRSSQEQGELQGRLAERESQ----EQGLRQR----------------------L 616
              +R  Q       + Q   AE E      EQ LRQ+                      L
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 617  LDEQFAVLRGAAAEAAGILQDAVSKLD---------DPLHLRCTSSPDYLVSRAQEALDA 667
            LDE+   L+  A EAA        +L            L  R  +    L+ R ++    
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 668  VSTLE-EGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCR 726
                E E   Q     A  S       R   LA + +    A +     +    + +  R
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 727  -ECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELK--PKSLDV---RQEELG 780
             +  A  L+   +L  +QA R     L     Q   QL +E +   ++L+    RQ E+ 
Sbjct: 2352 LKAEAELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2406

Query: 781  AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT 840
            A  ++     +       R  ED     + A      E+ E++    T+L    ++ +  
Sbjct: 2407 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR--TELATQEKVTLVQ 2459

Query: 841  STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLH---- 896
            +  +Q++  +S   A   +E  A+  R  E L   +K +   + ++     + +L     
Sbjct: 2460 TLEIQRQ--QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517

Query: 897  -----TGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVA 951
                   + + L+     I    A+L    + +  K        Q   + + +    +VA
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577

Query: 952  STKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGE----LRKQ 1007
            S +  + +  + +     G+   + + Q++E Q R  + E+ L  E  RL E    L +Q
Sbjct: 2578 SMEEARRRQHEAE----EGVRRKQEELQQLEQQRR--QQEELLAEENQRLREQLQLLEEQ 2631

Query: 1008 HYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLD 1055
            H     A+ +  EEV      A +++   +  L   P+     +H  D
Sbjct: 2632 H----RAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEPEHSFD 2674



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 151/697 (21%), Positives = 281/697 (40%), Gaps = 81/697 (11%)

Query: 364  EMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRA-- 421
            + L +E E I+L A+    Q + Q   LE EL   +++   A    ++L  ELA++RA  
Sbjct: 1734 QRLAAEQELIRLRAET--EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791

Query: 422  -------AQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
                   A+ E E S+   E+++++  A   R+ +L E+ + L    AE  ++    A++
Sbjct: 1792 EVLLASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARL-RALAEEAKRQRQLAEE 1849

Query: 475  LTVTQQSQEEVARVKEQLAF-QVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQE 533
                Q+++ E    ++  A  +  ++K E+E+ L+EK  + E+L+R  E +A +  R +E
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909

Query: 534  ALSHTEQSKSELSSRL--------DTLSAEKDALSGAVRQR---EADLLAAQSLVR---- 578
                  Q K+++  RL          L  +K  +   +RQR   E ++LA ++       
Sbjct: 1910 ---QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966

Query: 579  ---ETEAALSR-----EQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAE 630
               E E  L R     E    S+EQ EL+     + + E+  R+R  +E+      A  E
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 631  AAGILQDAV-------SKLDDPLHLRCTSSPDYL--VSRAQEALDAVSTLEEGHAQYLTS 681
            AA   + A+       +K+++   LR  +  +    +  AQEA  A   L+     +  +
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA--AQKRLQAEEKAHAFA 2084

Query: 682  LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECG-----ARALELM 736
            +      +    +      D +      +  A  +  +  +   RE           E +
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144

Query: 737  GQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIED 796
             Q  ++QA    QA      L+      +E + ++    Q E  A+  K+  A  A +E 
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQ--AADAEMEK 2196

Query: 797  AVRRIEDMMNQARHASS-----GVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
              +  E  + Q            ++LE  +   N   + ++ ++   T +   + ++ E 
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256

Query: 852  GRGAATQQEFYAKNSRWTEGLISASKAVGWGATQ--LVEAADKVVLHTGKYEELIVCSHE 909
                  Q E  +K     E    A        TQ  L E A+K+     +   L V + E
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316

Query: 910  IAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
             AA   QL  A +  A + +     L+E  + V E         K+  E ++ +  +   
Sbjct: 2317 -AARLRQL--AEEDLAQQRALAEKMLKEKMQAVQE-----ATRLKAEAELLQQQKELAQE 2368

Query: 970  GLSLIKLKKQEMETQV--RVLELEKTLEAERMRLGEL 1004
                ++  K++M  Q+       ++TLEAER R  E+
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 153/722 (21%), Positives = 289/722 (40%), Gaps = 104/722 (14%)

Query: 356  IESLKREVEMLRSELEKIKLEAQRYI-AQLKSQVNALEGELEEQRK-------QKQKALV 407
            +E L+ + E     L + ++E  R +   L++   + E EL+ +R        Q +++L 
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624

Query: 408  DNE----QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE 463
            +      QLR E  +    Q E ER+   REEAER+    + + N+      +   V  +
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERA---REEAERELERWQLKANEALRLRLQAEEVAQQ 1681

Query: 464  LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE------------------- 504
                 A+  KQ    ++      + +EQ   Q E  ++E E                   
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741

Query: 505  -LKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDAL--SG 561
             ++L  +++Q E+ ++ LE    ELAR Q   +   Q + EL + L  + AE + L  S 
Sbjct: 1742 LIRLRAETEQGEQQRQLLEE---ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798

Query: 562  AVRQREADLLAAQSLVR-ETEAALSRE------QQRSSQEQGELQGRLAERESQEQGLR- 613
            A  + E+   + +S  R E EA   RE      + R+  E+ + Q +LAE ++  Q    
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858

Query: 614  QRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEE 673
            +R+L E+ A    A  EA  +  +A   L +       +  + L   A++       LEE
Sbjct: 1859 ERVLAEKLA----AIGEATRLKTEAEIALKEK-----EAENERLRRLAEDEAFQRRRLEE 1909

Query: 674  GHAQYLTSLADASALV-----AALTRFSHLAADTIINGGATSH--LAPTDPADRLIDTCR 726
              AQ+   + +  A +     + L R   L  DT+          LA     ++      
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK-----A 1964

Query: 727  ECGARALEL-MGQLQD--QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVV 783
              G   LEL +G+++   +  LR  + + +    Q  L   +E + +  + R ++  A  
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT--- 840
            ++      AA+E+ V R++  + +AR      + E   ++  +     K ++        
Sbjct: 2025 EEAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083

Query: 841  ---------STSLQKE--IVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEA 889
                       +LQ+E  +++  RG A      A+ +   E  + A +       Q+ EA
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE--EARVQAEREAAQSRRQVEEA 2141

Query: 890  ADKVVLHTGKYEELIVCSHEIAASTAQLVAAS---KVKANKHSPHLSRLQECSRTVNERA 946
                       E L   + E A + AQ  AA+   + +A + +   ++ ++ +    + A
Sbjct: 2142 -----------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190

Query: 947  ANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGELR 1005
               +   K   EQ   +       L+ ++L+ +E + Q  +L+ E + L+AE       R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250

Query: 1006 KQ 1007
             Q
Sbjct: 2251 SQ 2252



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 90/330 (27%), Positives = 146/330 (44%), Gaps = 63/330 (19%)

Query: 355  QIESLKREVEMLRSE----LEKIK--LEAQRYIAQLKSQVNA--------LEGELEEQRK 400
            ++E  +R  E  R+E    L +++  LE QR +A+  +Q  A        L+  ++E+  
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 401  QKQKALVDNEQ----LRHELAQLRA---AQLEGERSQGLREEAERKASATEARYNKLKEK 453
            ++++A VD +Q    ++ EL QLR    A+++ +  Q    E  R     E R  +L+ +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489

Query: 454  HSELVHVHAE----LLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEE 509
             +E     AE     LR  A+ A+     +Q+QEE  R++ Q       V+ ES+ K + 
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQ-------VQDESQRKRQA 1540

Query: 510  KSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKD-----ALSGAVR 564
            + +   ++K E EA A E  RA +AL        E   RL     E+      AL  A R
Sbjct: 1541 EVELASRVKAEAEA-AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 565  QREADLLAAQSLVRETEAALSR--------------EQQRSSQEQGELQGRLAERESQ-- 608
              EA+L + ++   E  A L R              E +R +Q+Q E +    E E +  
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 609  ------EQGLRQRLLDEQFAVLRG-AAAEA 631
                   + LR RL  E+ A  +  A AEA
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 151/729 (20%), Positives = 289/729 (39%), Gaps = 107/729 (14%)

Query: 350  DDRDLQIESLKREVEMLRSELEKIKL---EAQRYIAQLKSQVNALEGELEEQRKQKQKAL 406
            D R  ++E L R++   R   + +     +A+R   Q+++   A    + EQ +Q+Q  L
Sbjct: 1223 DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1282

Query: 407  VDNEQLRHELAQLRA--------------------AQLEGERSQGLREEAERKASATEAR 446
             + E+   ++ + +                     AQLE   S   + + +  + +    
Sbjct: 1283 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342

Query: 447  YNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ-SQEEVARVKEQLA---FQVEQVKRE 502
            Y  L+  +SEL  + ++ ++  ++T +++   ++ ++++ A  +E+LA     +E+ ++ 
Sbjct: 1343 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402

Query: 503  SELKLEEKSDQLEKLKRELEAK-AGELARAQEALSHTEQSKSELSSRLDTLSAEKDA-LS 560
            +E   + K+ Q E+  +EL+ +   E+ R +EA    +Q K  +   L  L    +A + 
Sbjct: 1403 AEAHAQAKA-QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461

Query: 561  GAVRQREA---DLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA-------------- 603
               RQ EA     L  +  +R     L   +++    +GELQ   A              
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521

Query: 604  -----ERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYL- 657
                  R+ Q++  R+R  + + A    A AEAA   Q A+  L++ L L+   +   L 
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-LRLQAEEAERRLR 1580

Query: 658  ---VSRAQEALDAVSTLEEGHAQYL----TSLADASALVAALTRFSHLAADTIINGGATS 710
               V RA++   A+ T +      L     S A+ +A +    +  H+A    +   A  
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV-AQLREEAER 1639

Query: 711  HLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPK 770
                   A+R     RE   R LE   QL+  +ALR              LQ  +  + K
Sbjct: 1640 RAQQQAEAER----AREEAERELE-RWQLKANEALRLR------------LQAEEVAQQK 1682

Query: 771  SL-DVRQEELGAVVDKEMAATSAAIEDAVRRIE------DMMNQARHASSGVKLEVNERI 823
            SL     E+     ++E      A E AVR+ E      +   Q    ++  +L   + +
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742

Query: 824  LNSCTDLMKA---IRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLI-SASKAV 879
            +    +  +     +LL      LQ+E   + +     +   AK     E L+ S ++A 
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802

Query: 880  GWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECS 939
                +   ++  ++    G++ EL   + E A   A    A + +         +  E  
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFREL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859

Query: 940  RTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERM 999
            R + E+ A +  +T+   E             + I LK++E E + R+  L +    +R 
Sbjct: 1860 RVLAEKLAAIGEATRLKTE-------------AEIALKEKEAENE-RLRRLAEDEAFQRR 1905

Query: 1000 RLGELRKQH 1008
            RL E   QH
Sbjct: 1906 RLEEQAAQH 1914



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/410 (22%), Positives = 167/410 (40%), Gaps = 41/410 (10%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            R L  E L ++   L  ++ K K++A +   +LK++   L+ + E  ++Q ++   D EQ
Sbjct: 2321 RQLAEEDLAQQ-RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAE----LLRK 467
            +  +LA     + +G +     E   +   + EA   KL+          AE      RK
Sbjct: 2380 MAQQLA----EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435

Query: 468  NA-DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKREL--EAK 524
             A +  ++L  T+ + +E   + + L  Q +Q   ++E +L E   +LE+ K +L  EAK
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE-RLREAIAELEREKEKLQQEAK 2494

Query: 525  AGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEA-- 582
              +L   +      EQ   E  +   +  +EKD+L    R  E +    + L ++  A  
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554

Query: 583  -ALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSK 641
              L  EQQR  Q+  + + RL    S E+  R+          +  A E     Q+ + +
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLV--ASMEEARRR----------QHEAEEGVRRKQEELQQ 2602

Query: 642  LDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAAD 701
            L+     +     + L    Q   + +  LEE H   L    + +A   A T+       
Sbjct: 2603 LEQ----QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK------- 2651

Query: 702  TIING--GATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQ 749
            T+ NG        A  +P        R+  A+ L+  G L  ++  R  Q
Sbjct: 2652 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 151/706 (21%), Positives = 265/706 (37%), Gaps = 78/706 (11%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            L I   +   E+LR+  E++K EAQ   A L  ++ A +  L++ R Q +      + LR
Sbjct: 1120 LVIRGTQGAEEVLRAHEEQLK-EAQAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALR 1177

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             EL   R AQ  GER Q    E + +      R  +L E+   ++       R+     +
Sbjct: 1178 DEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKR---ESELKLEEKSDQLEKLKRELEAKAGELAR 530
            QL   ++S + +    +    + EQ++         + E+  Q + L  E+E    ++  
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDAL------------SGAVRQREADL-------- 570
             Q        +  +   +L T  A+ + +            S +V Q   DL        
Sbjct: 1295 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1354

Query: 571  -LAAQ--SLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGA 627
             L +Q    + ET   +  E++ + Q++ E + RLAE E+  +  +QR L E  A  +  
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQ 1412

Query: 628  AAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASA 687
            A   A  LQ    ++ + +  R  ++ D    +     +     +   A+       A A
Sbjct: 1413 AEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469

Query: 688  LVAALTRFS--------HLAADTIINGGATSHL-APTDPADRLIDTCRECGARALELMGQ 738
               +  R           L A     GGA   L A    A+      R+    A  L  Q
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 739  LQDQQALRHMQ----ASLVRTPL------QGILQLGQELKPKSLDVRQEELGAVVDKEMA 788
            +QD+   +       AS V+         Q  LQ  +EL+ ++ +  +    A V++   
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER-AR 1588

Query: 789  ATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEI 848
                A+E A R  E  + Q++ AS   K    ER L      +  +R         Q E 
Sbjct: 1589 QVQVALETAQRSAEAEL-QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647

Query: 849  VESGRGAATQQEFY------AKNSRWTEGLISASKAVGWG-ATQLVEAADKVVLHTGKYE 901
              +   A  + E +      A   R     ++  K++    A +  E A++     GK E
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707

Query: 902  ELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQ-- 959
            E  V   E+A    +L    ++        L+  QE  R        + A T+ G++Q  
Sbjct: 1708 EQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIR--------LRAETEQGEQQRQ 1757

Query: 960  -IEDRDTMDFSGLSLIKLKKQEMETQVRVLELE-KTLEAERMRLGE 1003
             +E+         +    K+QE+E ++  +  E + L A + R  E
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 136/688 (19%), Positives = 264/688 (38%), Gaps = 67/688 (9%)

Query: 357  ESLKREVEMLRS----ELEKIKLEAQR---YIAQLKSQVNALEGELEEQRKQKQKALVDN 409
            +SL+R+V+++RS        +K E QR   +  +L  Q    + +       + + + + 
Sbjct: 924  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 983

Query: 410  EQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            E   +        QL     QG +EE+  +   +E +  +L+ +  E   VH   L  + 
Sbjct: 984  E---YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1040

Query: 470  DTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESE--LKLEEKSDQLEKLKRELEAKAGE 527
            + A++       Q++     E L   V ++  E+E  L L E S     L+ ELE   G+
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100

Query: 528  LARAQE--------------ALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAA 573
            L + +                +  T+ ++  L +  + L  E  A+   + + EA   + 
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKASL 1159

Query: 574  QSLVRETEAA-----LSREQQRSSQEQGE-LQGRLAERESQEQGLRQR---LLDEQFAVL 624
            + L  + EA        R++ R +QE GE LQ R  ER+ + +  R+R   LL+   AVL
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219

Query: 625  -----RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYL 679
                 R    E  G       +  DPL      +      R QE + A+   +    +  
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA-----RRRQEQIQAMPLADSQAVR-- 1272

Query: 680  TSLADASALVAALTRFSHLA------ADTIINGGATSHLAPTDPADRLIDTCRECGARAL 733
              L    AL+  + R           A   IN      L       +L           +
Sbjct: 1273 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1332

Query: 734  ELMGQ--LQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATS 791
            +   +  +Q+   LR   + L     Q I  + + L+    + R  E     ++E  A  
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392

Query: 792  AAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVES 851
             A  +  R++ +   QA+  +     E+ +R+        +A         S+Q+E+ + 
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452

Query: 852  GRGAATQQEFYAKNSRWTE-GLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEI 910
             + +  + +  A+ +   E   +   + +     QL EA ++     G   EL     + 
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATER--QRGGAEGEL-----QA 1504

Query: 911  AASTAQLVAASKVKANKHSPHLSR-LQECSRTVNERAANVVASTKSGQEQIEDRDTMDFS 969
              + A+   A K +A + +  L R +Q+ S+   +    + +  K+  E   ++      
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-LQ 1563

Query: 970  GLSLIKLKKQEMETQVRVLELEKTLEAE 997
             L  ++L+ +E E ++R  E+E+  + +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQ 1591


>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
          Length = 670

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 82/321 (25%), Positives = 148/321 (46%), Gaps = 47/321 (14%)

Query: 355 QIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRH 414
           Q++ L+R+    + +L + + E     A+LK +    E  L+ ++++ +++L D+E LR 
Sbjct: 375 QVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434

Query: 415 ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
           +  +     LE E  + ++E  +R     EA    L+E   EL  V A  L +     ++
Sbjct: 435 KEVEHMTRHLE-ESEKAMQERVQR----LEAARLSLEE---ELSRVKAAALSERGQAEEE 486

Query: 475 LTVTQ-----QSQEEVARVKEQL-------------AFQVEQVKRESELKLEEKSDQLEK 516
           L   +     + Q+ +A ++++L               Q +QV  E++ ++ +   Q+E 
Sbjct: 487 LIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEG 546

Query: 517 LKRELEAKAGELA-RAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQS 575
           L+R LE    EL+ + QE ++   + + EL  +   L AE               LAAQ 
Sbjct: 547 LRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAE---------------LAAQE 591

Query: 576 LVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ--RLLDEQFAVLRGAAAEAAG 633
            +RE  AAL R+ +  + +  E    L +RES+   LR+  RL + + A +R   A+ A 
Sbjct: 592 ALREKAAALERQLKVMASDHRE---ALLDRESENASLREKLRLREAEIARIRDEEAQRAS 648

Query: 634 ILQDAVSKLDDPLHLRCTSSP 654
            LQ+AV        +R  S P
Sbjct: 649 FLQNAVLAYVQASPVRTLSPP 669



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 81/373 (21%), Positives = 152/373 (40%), Gaps = 59/373 (15%)

Query: 348 VKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVN---ALEGELEEQRKQKQK 404
           +++++  Q   L   ++  R E+ K    +   + QL+  +N   ++   L+ + +  + 
Sbjct: 251 LREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEA 310

Query: 405 ALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEA--RYNKL-------KEKHS 455
           AL  +EQ   +L +L A   + + S   R+  E K    EA  R +KL        EK+ 
Sbjct: 311 ALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNL 370

Query: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQ----------------- 498
            L +   EL RK     +QL  T+Q    ++   +  A Q E+                 
Sbjct: 371 LLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430

Query: 499 ---VK---------RESELKLEEKSDQLEKLKRELE--------AKAGELARAQEAL--- 535
              +K          ESE  ++E+  +LE  +  LE        A   E  +A+E L   
Sbjct: 431 SLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKA 490

Query: 536 -----SHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQR 590
                   +Q  + L  +L  L+  +D   GA  Q++  +  AQ+ V +    +   ++R
Sbjct: 491 KSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRR 550

Query: 591 SSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRC 650
             + Q EL  +  ER ++   +R  L ++   +    AA+ A  L++  + L+  L +  
Sbjct: 551 LEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLKVMA 608

Query: 651 TSSPDYLVSRAQE 663
           +   + L+ R  E
Sbjct: 609 SDHREALLDRESE 621



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 354 LQIESLKREVEMLRSEL----EKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDN 409
           LQ+E L+R +E L+ EL    ++   E  R   +L+ Q   L+ EL  Q   ++KA    
Sbjct: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601

Query: 410 EQLRHELAQLRAAQLEGERSQGLREEAERKASATEAR 446
            QL+   +  R A L+ E       E  R   A  AR
Sbjct: 602 RQLKVMASDHREALLDRESENASLREKLRLREAEIAR 638


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
            E  ++E+E L+ +LE    +    IA L++Q+  L+ +L ++ ++ Q AL  +D+E  + 
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
              A  +  +LEG  S  L+E+ + + +A      + ++   EL  +  EL      TA Q
Sbjct: 1107 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165

Query: 475  LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
              +  + ++EV  +K+ L         QV++++++    +EE ++QLE+ KR        
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 520  ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
                                          +LEA+  EL   Q   S  E++++EL+ ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1282

Query: 550  DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
              L  E ++++G + + E        D+ +  S +++T+  L  E ++      +L+   
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 603  AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
             ER S +  L + +     L+   + L    +++   LQD  S ++  +    R     +
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 656  YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
             L  + +E   A   LE+   +    L D            S L     +F  L A+   
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1459

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
                +S  A  D  DR     RE   +AL L   L++  +A   ++ +  +++  ++ ++
Sbjct: 1460 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517

Query: 762  ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
                 +G+     E   ++L+ + EE+   ++ E+     A EDA  R+E  M   +   
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1573

Query: 813  SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
               + ++  R   +     +  R L    T L+ E  +    AA +++            
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633

Query: 873  ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
             SA K       QL +   ++     + E+      EI A+  +    ++ KA      L
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1689

Query: 933  SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
             +LQE      ERA       K   E++ +      SG + ++ +K+ +E   R+ +LE+
Sbjct: 1690 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1743

Query: 993  TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
             LE E+  +  +  +       +     E+A   STA ++ + ++
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
            RD Q E  +R+++    E E    + ++  A   +    LEG+L++   Q   A+   E 
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642

Query: 411  ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
               QLR   AQ++  Q E E ++  R+E        E+KA + EA   +L+E  +     
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1698

Query: 461  HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
             AE  RK AD  K+         L+     Q+E  R++ ++A Q+E+   E +  +E  S
Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1756

Query: 512  DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
            D++ K  ++ E  + ELA  +      E ++ +L  +   L ++   + GAV+ +    +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 572  AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
            AA       EA +++ +++  QE  E Q      + +++ L++ LL
Sbjct: 1817 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
            + LQ E  K   +ML  E +  + EA R   QL+     +++  LE E+     Q  K  
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 407  VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
             + + L   ++ L         +  L EE E+  + T     KLK KH  ++      L+
Sbjct: 999  KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1044

Query: 467  KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
            K   + ++L   ++                Q ++A +K QLA + E++            
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104

Query: 500  -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
                                         + ++E +  +  ++LE LK ELE      A 
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
             QE  +  EQ  + L   LD  +   +A    +RQ+ A    +L       +  +A L +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 587  EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
             +Q   +E  +L G  R+  +  QE   +++ L+ Q   L+   ++     + A ++L+D
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1280

Query: 645  PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
             +H +  +  + +     EA      L +  A   + L D   L+   TR   L   T +
Sbjct: 1281 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1338

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
                    +  D  D  ++  +        L  QL D +      AS V    +G  +  
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 765  QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
            +E+  ++L  + EE  A  DK     +   ++    + D+ NQ +  S+   LE  +R  
Sbjct: 1399 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1451

Query: 825  NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
                   K  +LL        K   E  R  A  +E   K       L  A +     A 
Sbjct: 1452 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1499

Query: 885  QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
            + +E  +K++    + E+L+    ++  +  +L  + +    +     ++L+E    +  
Sbjct: 1500 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557

Query: 944  ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
                      N+ A     +  ++ RD  +      ++ +  E ET++     ++ L A 
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617

Query: 998  RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
              +  E   +   L   S   G E AI+
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK 1645



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            LQ+   + E++    EL+K K   Q+   +LK ++     +L E++   Q+ L    +L 
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             E  ++R       R    ++E E      EAR  + +++  +L     ++ ++  D  +
Sbjct: 904  AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
            QL      +EE AR K     Q+E+V  E+++K        +++++++L K ++ LE + 
Sbjct: 958  QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008

Query: 526  GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
             +    LA  +E   +  + K       SEL  RL      +  L    R+ E D     
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 575  SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
              + + +A ++  + + ++++ ELQ  LA    E   +   L+            Q  LD
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 619  EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
             + A    A  +   +   L+   ++L+D L    T     +  +  V+  ++ALD  + 
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188

Query: 671  LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
              E   Q +          L   L +F    A+ +     T      D A  L       
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 726  RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
            +E   +  +L  Q+Q+ Q+ +       R  L   + +L  E++  +  + + E  A+ +
Sbjct: 1248 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
             K++A+ S+ ++D    +++   Q  + S+ ++    ER  + +   + M+A + L    
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 842  TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
            ++L  ++ +S +     A+T +       R+ + + + +     KA  +        +L 
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 888  EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
            +  D +V+      +L+    +      QL+A  K  ++K++    R +  +R   E+  
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1483

Query: 948  NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
              ++  ++ +E +E ++ ++ +     K+ K EME  V         V ELEK+  A   
Sbjct: 1484 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 1000 RLGELRKQ 1007
            ++ E++ Q
Sbjct: 1540 QMEEMKTQ 1547



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)

Query: 355  QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            ++  L+ EVE +    +E E   ++  + +A L SQ+   +  L+E+ +QK        Q
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
            L  E   L+  QL+ E     ++  ER  S    + +  K+K  +       L       
Sbjct: 1341 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 472  AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
             K++  +TQQ +E+ A                         + QL   +E+ +R+  +L 
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 507  LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
             EEK+         D+ E   RE E KA  LARA +EAL   E+                
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517

Query: 541  -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
             SK ++   +  L   K AL   + + +  L   +  ++ TE A  R +      +G+ +
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577

Query: 600  GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
              L  R+ Q +  R   QR L E          Q A+   A  +  G L+D   + D  +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 647  HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
              R  +       +AQ      E  DA ++ +E  A    +   A +L A L +      
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 696  ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
                +   AD      A    +     + L D  R   AR  +L  +L+++Q      + 
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757

Query: 752  LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
             VR   Q   QL  EL                   + K L  +  E+   V  +  +T A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 793  AIEDAVRRIEDMMNQ-ARHASSGVK 816
            A+E  + ++E+ + Q AR   +  K
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATK 1842



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%)

Query: 353  DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            DL+ E L  E+    S     + EK +LEA+  IAQL+ ++   +G +E    + +KA  
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1764

Query: 408  DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 462
              EQL +ELA  R  A + E  R Q  R+  E ++   E   A  +K K   + L    A
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824

Query: 463  ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 519
            +L  +    A++     +S ++  +  +++  QVE  ++ +E    + E+ + ++++LKR
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884

Query: 520  ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
            +LE    E  R        ++   E +   + +  E +AL   +R+
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
            E  ++E+E L+ +LE    +    IA L++Q+  L+ +L ++ ++ Q AL  +D+E  + 
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
              A  +  +LEG  S  L+E+ + + +A      + ++   EL  +  EL      TA Q
Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 475  LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
              +  + ++EV  +K+ L         QV++++++    +EE ++QLE+ KR        
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 520  ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
                                          +LEA+  EL   Q   S  E++++EL+ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289

Query: 550  DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
              L  E ++++G + + E        D+ +  S +++T+  L  E ++      +L+   
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 603  AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
             ER S +  L + +     L+   + L    +++   LQD  S ++  +    R     +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 656  YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
             L  + +E   A   LE+   +    L D            S L     +F  L A+   
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
                +S  A  D  DR     RE   +AL L   L++  +A   ++ +  +++  ++ ++
Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524

Query: 762  ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
                 +G+     E   ++L+ + EE+   ++ E+     A EDA  R+E  M   +   
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580

Query: 813  SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
               + ++  R   +     +  R L    T L+ E  +    AA +++            
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640

Query: 873  ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
             SA K       QL +   ++     + E+      EI A+  +    ++ KA      L
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696

Query: 933  SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
             +LQE      ERA       K   E++ +      SG + ++ +K+ +E   R+ +LE+
Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750

Query: 993  TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
             LE E+  +  +  +       +     E+A   STA ++ + ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
            RD Q E  +R+++    E E    + ++  A   +    LEG+L++   Q   A+   E 
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649

Query: 411  ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
               QLR   AQ++  Q E E ++  R+E        E+KA + EA   +L+E  +     
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705

Query: 461  HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
             AE  RK AD  K+         L+     Q+E  R++ ++A Q+E+   E +  +E  S
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763

Query: 512  DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
            D++ K  ++ E  + ELA  +      E ++ +L  +   L ++   + GAV+ +    +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 572  AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
            AA       EA +++ +++  QE  E Q      + +++ L++ LL
Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
            + LQ E  K   +ML  E +  + EA R   QL+     +++  LE E+     Q  K  
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 407  VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
             + + L   ++ L         +  L EE E+  + T     KLK KH  ++      L+
Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051

Query: 467  KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
            K   + ++L   ++                Q ++A +K QLA + E++            
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 500  -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
                                         + ++E +  +  ++LE LK ELE      A 
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
             QE  +  EQ  + L   LD  +   +A    +RQ+ A    +L       +  +A L +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 587  EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
             +Q   +E  +L G  R+  +  QE   +++ L+ Q   L+   ++     + A ++L+D
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287

Query: 645  PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
             +H +  +  + +     EA      L +  A   + L D   L+   TR   L   T +
Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
                    +  D  D  ++  +        L  QL D +      AS V    +G  +  
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 765  QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
            +E+  ++L  + EE  A  DK     +   ++    + D+ NQ +  S+   LE  +R  
Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458

Query: 825  NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
                   K  +LL        K   E  R  A  +E   K       L  A +     A 
Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506

Query: 885  QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
            + +E  +K++    + E+L+    ++  +  +L  + +    +     ++L+E    +  
Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564

Query: 944  ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
                      N+ A     +  ++ RD  +      ++ +  E ET++     ++ L A 
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 998  RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
              +  E   +   L   S   G E AI+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            LQ+   + E++    EL+K K   Q+   +LK ++     +L E++   Q+ L    +L 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             E  ++R       R    ++E E      EAR  + +++  +L     ++ ++  D  +
Sbjct: 911  AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
            QL      +EE AR K     Q+E+V  E+++K        +++++++L K ++ LE + 
Sbjct: 965  QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015

Query: 526  GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
             +    LA  +E   +  + K       SEL  RL      +  L    R+ E D     
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 575  SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
              + + +A ++  + + ++++ ELQ  LA    E   +   L+            Q  LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 619  EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
             + A    A  +   +   L+   ++L+D L    T     +  +  V+  ++ALD  + 
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195

Query: 671  LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
              E   Q +          L   L +F    A+ +     T      D A  L       
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 726  RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
            +E   +  +L  Q+Q+ Q+ +       R  L   + +L  E++  +  + + E  A+ +
Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
             K++A+ S+ ++D    +++   Q  + S+ ++    ER  + +   + M+A + L    
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 842  TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
            ++L  ++ +S +     A+T +       R+ + + + +     KA  +        +L 
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 888  EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
            +  D +V+      +L+    +      QL+A  K  ++K++    R +  +R   E+  
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490

Query: 948  NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
              ++  ++ +E +E ++ ++ +     K+ K EME  V         V ELEK+  A   
Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 1000 RLGELRKQ 1007
            ++ E++ Q
Sbjct: 1547 QMEEMKTQ 1554



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)

Query: 355  QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            ++  L+ EVE +    +E E   ++  + +A L SQ+   +  L+E+ +QK        Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
            L  E   L+  QL+ E     ++  ER  S    + +  K+K  +       L       
Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 472  AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
             K++  +TQQ +E+ A                         + QL   +E+ +R+  +L 
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 507  LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
             EEK+         D+ E   RE E KA  LARA +EAL   E+                
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524

Query: 541  -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
             SK ++   +  L   K AL   + + +  L   +  ++ TE A  R +      +G+ +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

Query: 600  GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
              L  R+ Q +  R   QR L E          Q A+   A  +  G L+D   + D  +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 647  HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
              R  +       +AQ      E  DA ++ +E  A    +   A +L A L +      
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 696  ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
                +   AD      A    +     + L D  R   AR  +L  +L+++Q      + 
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 752  LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
             VR   Q   QL  EL                   + K L  +  E+   V  +  +T A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 793  AIEDAVRRIEDMMNQ-ARHASSGVK 816
            A+E  + ++E+ + Q AR   +  K
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 15/226 (6%)

Query: 353  DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            DL+ E L  E+    S     + EK +LEA+  IAQL+ ++   +G +E    + +KA  
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771

Query: 408  DNEQLRHELAQLR--AAQLEGERSQGLREEAERKASATE---ARYNKLKEKHSELVHVHA 462
              EQL +ELA  R  A + E  R Q  R+  E ++   E   A  +K K   + L    A
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831

Query: 463  ELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESEL---KLEEKSDQLEKLKR 519
            +L  +    A++     +S ++  +  +++  QVE  ++ +E    + E+ + ++++LKR
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891

Query: 520  ELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQ 565
            +LE    E  R        ++   E +   + +  E +AL   +R+
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 156/765 (20%), Positives = 314/765 (41%), Gaps = 107/765 (13%)

Query: 357  ESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKAL--VDNEQLRH 414
            E  ++E+E L+ +LE    +    IA L++Q+  L+ +L ++ ++ Q AL  +D+E  + 
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 415  ELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQ 474
              A  +  +LEG  S  L+E+ + + +A      + ++   EL  +  EL      TA Q
Sbjct: 1114 NNALKKIRELEGHISD-LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 475  LTVTQQSQEEVARVKEQL-------AFQVEQVKRESELKLEEKSDQLEKLKR-------- 519
              +  + ++EV  +K+ L         QV++++++    +EE ++QLE+ KR        
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 520  ------------------------------ELEAKAGELARAQEALSHTEQSKSELSSRL 549
                                          +LEA+  EL   Q   S  E++++EL+ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKV 1289

Query: 550  DTLSAEKDALSGAVRQREA-------DLLAAQSLVRETEAALSREQQRSSQEQGELQGRL 602
              L  E ++++G + + E        D+ +  S +++T+  L  E ++      +L+   
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 603  AERESQEQGLRQRL-----LDEQFAVLRGAAAEAAGILQDAVSKLD--DPLHLRCTSSPD 655
             ER S +  L + +     L+   + L    +++   LQD  S ++  +    R     +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 656  YLVSRAQEALDAVSTLEEGHAQYLTSLAD-----------ASALVAALTRFSHLAADTII 704
             L  + +E   A   LE+   +    L D            S L     +F  L A+   
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE--- 1466

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQ-QALRHMQAS--LVRTPLQGIL 761
                +S  A  D  DR     RE   +AL L   L++  +A   ++ +  +++  ++ ++
Sbjct: 1467 EKNISSKYA--DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524

Query: 762  ----QLGQ-----ELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHAS 812
                 +G+     E   ++L+ + EE+   ++ E+     A EDA  R+E  M   +   
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQATEDAKLRLEVNMQALK--- 1580

Query: 813  SGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGL 872
               + ++  R   +     +  R L    T L+ E  +    AA +++            
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640

Query: 873  ISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHL 932
             SA K       QL +   ++     + E+      EI A+  +    ++ KA      L
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE----NEKKAKSLEADL 1696

Query: 933  SRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEK 992
             +LQE      ERA       K   E++ +      SG + ++ +K+ +E   R+ +LE+
Sbjct: 1697 MQLQE-DLAAAERARKQADLEK---EELAEELASSLSGRNALQDEKRRLE--ARIAQLEE 1750

Query: 993  TLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKK 1037
             LE E+  +  +  +       +     E+A   STA ++ + ++
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNE- 410
            RD Q E  +R+++    E E    + ++  A   +    LEG+L++   Q   A+   E 
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649

Query: 411  ---QLRHELAQLRAAQLEGERSQGLREEA-------ERKASATEARYNKLKEKHSELVHV 460
               QLR   AQ++  Q E E ++  R+E        E+KA + EA   +L+E  +     
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---- 1705

Query: 461  HAELLRKNADTAKQ---------LTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKS 511
             AE  RK AD  K+         L+     Q+E  R++ ++A Q+E+   E +  +E  S
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMS 1763

Query: 512  DQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLL 571
            D++ K  ++ E  + ELA  +      E ++ +L  +   L ++   + GAV+ +    +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 572  AAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLL 617
            AA       EA +++ +++  QE  E Q      + +++ L++ LL
Sbjct: 1824 AA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 146/748 (19%), Positives = 275/748 (36%), Gaps = 115/748 (15%)

Query: 352  RDLQIESLKREVEMLRSELEKIKLEAQRYIAQLK-----SQVNALEGELEEQRKQKQKAL 406
            + LQ E  K   +ML  E +  + EA R   QL+     +++  LE E+     Q  K  
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 407  VDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLR 466
             + + L   ++ L         +  L EE E+  + T     KLK KH  ++      L+
Sbjct: 1006 KERKLLEERISDL---------TTNLAEEEEKAKNLT-----KLKNKHESMISELEVRLK 1051

Query: 467  KNADTAKQLTVTQQS---------------QEEVARVKEQLAFQVEQV------------ 499
            K   + ++L   ++                Q ++A +K QLA + E++            
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 500  -----------------------------KRESELKLEEKSDQLEKLKRELEAKAGELAR 530
                                         + ++E +  +  ++LE LK ELE      A 
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171

Query: 531  AQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREA----DLLAAQSLVRETEAALSR 586
             QE  +  EQ  + L   LD  +   +A    +RQ+ A    +L       +  +A L +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 587  EQQRSSQEQGELQG--RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD 644
             +Q   +E  +L G  R+  +  QE   +++ L+ Q   L+   ++     + A ++L+D
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG----ERARAELND 1287

Query: 645  PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTII 704
             +H +  +  + +     EA      L +  A   + L D   L+   TR   L   T +
Sbjct: 1288 KVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKL 1345

Query: 705  NGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLG 764
                    +  D  D  ++  +        L  QL D +      AS V    +G  +  
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 765  QELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL 824
            +E+  ++L  + EE  A  DK     +   ++    + D+ NQ +  S+   LE  +R  
Sbjct: 1406 KEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN---LEKKQR-- 1458

Query: 825  NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGAT 884
                   K  +LL        K   E  R  A  +E   K       L  A +     A 
Sbjct: 1459 -------KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-----AK 1506

Query: 885  QLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVN- 943
            + +E  +K++    + E+L+    ++  +  +L  + +    +     ++L+E    +  
Sbjct: 1507 EELERTNKML--KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564

Query: 944  ------ERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAE 997
                      N+ A     +  ++ RD  +      ++ +  E ET++     ++ L A 
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 998  RMRLGELRKQHYVLAGASGSPGEEVAIR 1025
              +  E   +   L   S   G E AI+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK 1652



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 143/728 (19%), Positives = 303/728 (41%), Gaps = 99/728 (13%)

Query: 354  LQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLR 413
            LQ+   + E++    EL+K K   Q+   +LK ++     +L E++   Q+ L    +L 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 414  HELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAK 473
             E  ++R       R    ++E E      EAR  + +++  +L     ++ ++  D  +
Sbjct: 911  AEAEEMRV------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 474  QLTVTQQSQEEVARVKEQLAFQVEQVKRESELK--------LEEKSDQLEKLKRELEAKA 525
            QL      +EE AR K     Q+E+V  E+++K        +++++++L K ++ LE + 
Sbjct: 965  QL-----EEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015

Query: 526  GE----LARAQEALSHTEQSK-------SELSSRLDTLSAEKDALSGAVRQREADLLAAQ 574
             +    LA  +E   +  + K       SEL  RL      +  L    R+ E D     
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 575  SLVRETEAALSREQQRSSQEQGELQGRLA----ERESQEQGLR------------QRLLD 618
              + + +A ++  + + ++++ ELQ  LA    E   +   L+            Q  LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 619  EQFAVLRGAAAEAAGI---LQDAVSKLDDPLHLRCT-----SSPDYLVSRAQEALDAVST 670
             + A    A  +   +   L+   ++L+D L    T     +  +  V+  ++ALD  + 
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195

Query: 671  LEEGHAQYLTS--LADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLI---DTC 725
              E   Q +          L   L +F    A+ +     T      D A  L       
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 726  RECGARALELMGQLQDQQALRHMQASLVRTPLQG-ILQLGQELKPKSLDVRQEELGAV-V 783
            +E   +  +L  Q+Q+ Q+ +       R  L   + +L  E++  +  + + E  A+ +
Sbjct: 1255 QEVEHKKKKLEAQVQELQS-KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313

Query: 784  DKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNER--ILNSCTDLMKAIRLLVTTS 841
             K++A+ S+ ++D    +++   Q  + S+ ++    ER  + +   + M+A + L    
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 842  TSLQKEIVESGRG----AATQQEFYAKNSRWTEGLISAS-----KAVGWG-----ATQLV 887
            ++L  ++ +S +     A+T +       R+ + + + +     KA  +        +L 
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 888  EAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAA 947
            +  D +V+      +L+    +      QL+A  K  ++K++    R +  +R   E+  
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---EKET 1490

Query: 948  NVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQV--------RVLELEKTLEAERM 999
              ++  ++ +E +E ++ ++ +     K+ K EME  V         V ELEK+  A   
Sbjct: 1491 KALSLARALEEALEAKEELERTN----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 1000 RLGELRKQ 1007
            ++ E++ Q
Sbjct: 1547 QMEEMKTQ 1554



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 126/565 (22%), Positives = 212/565 (37%), Gaps = 106/565 (18%)

Query: 355  QIESLKREVEMLR---SELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQ 411
            ++  L+ EVE +    +E E   ++  + +A L SQ+   +  L+E+ +QK        Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 412  LRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT 471
            L  E   L+  QL+ E     ++  ER  S    + +  K+K  +       L       
Sbjct: 1348 LEEERNSLQ-DQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 472  AKQL-TVTQQSQEEVARV-----------------------KEQLAFQVEQVKRE-SELK 506
             K++  +TQQ +E+ A                         + QL   +E+ +R+  +L 
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 507  LEEKS---------DQLEKLKRELEAKAGELARA-QEALSHTEQ---------------- 540
             EEK+         D+ E   RE E KA  LARA +EAL   E+                
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524

Query: 541  -SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
             SK ++   +  L   K AL   + + +  L   +  ++ TE A  R +      +G+ +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

Query: 600  GRLAERESQEQGLR---QRLLDE----------QFAVLRGAAAEAAGILQDAVSKLDDPL 646
              L  R+ Q +  R   QR L E          Q A+   A  +  G L+D   + D  +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 647  HLRCTSSPDYLVSRAQ------EALDAVSTLEEGHAQYLTSLADASALVAALTRF----- 695
              R  +       +AQ      E  DA ++ +E  A    +   A +L A L +      
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 696  ----SHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQAS 751
                +   AD      A    +     + L D  R   AR  +L  +L+++Q      + 
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 752  LVRTPLQGILQLGQEL-------------------KPKSLDVRQEELGAVVDKEMAATSA 792
             VR   Q   QL  EL                   + K L  +  E+   V  +  +T A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 793  AIEDAVRRIEDMMNQ-ARHASSGVK 816
            A+E  + ++E+ + Q AR   +  K
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATK 1849



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 37/257 (14%)

Query: 353  DLQIESLKREVEMLRS-----ELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALV 407
            DL+ E L  E+    S     + EK +LEA+  IAQL+ ++   +G +E    + +KA  
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQGNMEAMSDRVRKATQ 1771

Query: 408  DNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRK 467
              EQL +ELA  R+     ++++  R++ ER+           KE  S+L  +   +  K
Sbjct: 1772 QAEQLSNELATERST---AQKNESARQQLERQN----------KELRSKLHEMEGAVKSK 1818

Query: 468  NADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGE 527
               T   L      + ++A+++EQ    VEQ  RE +   +    + +KLK  L     E
Sbjct: 1819 FKSTIAAL------EAKIAQLEEQ----VEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868

Query: 528  LARAQEALSHTEQSKS---ELSSRLDTLSAEKDALSGAVRQREADLLAA----QSLVRET 580
               A++     E+  +   +L  +L+    E   ++   R+ + +L  A    +++ RE 
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928

Query: 581  EAALSREQQRSSQEQGE 597
             A  S+ +    QE  +
Sbjct: 1929 NALKSKLRGPPPQETSQ 1945


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,597,125
Number of Sequences: 37866
Number of extensions: 1644812
Number of successful extensions: 16810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 1081
Number of HSP's that attempted gapping in prelim test: 7288
Number of HSP's gapped (non-prelim): 5298
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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