Guide to the Human Genome
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Search of human proteins with 4826948

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826948 protein kinase, X-linked [Homo sapiens]
         (358 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826948 protein kinase, X-linked [Homo sapiens]                    744   0.0  
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   374   e-104
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   374   e-104
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   371   e-103
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   371   e-103
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   345   5e-95
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...   292   3e-79
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho...   292   3e-79
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]     285   4e-77
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta...   278   4e-75
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       255   5e-68
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      255   5e-68
gi|4502023 AKT2 kinase [Homo sapiens]                                 254   6e-68
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   250   1e-66
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   250   2e-66
gi|62241015 AKT1 kinase [Homo sapiens]                                248   5e-66
gi|62241013 AKT1 kinase [Homo sapiens]                                248   5e-66
gi|62241011 AKT1 kinase [Homo sapiens]                                248   5e-66
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   247   1e-65
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   247   1e-65
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   247   1e-65
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   247   1e-65
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   246   3e-65
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   242   3e-64
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   242   3e-64
gi|5453974 protein kinase N2 [Homo sapiens]                           236   3e-62
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                236   3e-62
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                236   3e-62
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   233   2e-61
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   231   1e-60

>gi|4826948 protein kinase, X-linked [Homo sapiens]
          Length = 358

 Score =  744 bits (1920), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF 60
           MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF
Sbjct: 1   MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF 60

Query: 61  GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER 120
           GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER
Sbjct: 61  GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER 120

Query: 121 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL 180
           FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL
Sbjct: 121 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL 180

Query: 181 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG 240
           DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG
Sbjct: 181 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG 240

Query: 241 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH 300
           FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH
Sbjct: 241 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH 300

Query: 301 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 358
           RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
Sbjct: 301 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 358


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  374 bits (959), Expect = e-104
 Identities = 165/295 (55%), Positives = 225/295 (76%)

Query: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
           L+DF+   T+GTG+FGRV LVK K  + ++A+K++    V++LKQ +H  NEK +L+ V+
Sbjct: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100

Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
            PFL+RL + + D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+   EYLHS
Sbjct: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160

Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
            +++YRDLKPEN+L+D  G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220

Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
           DWWALG+LI+EM +G+PPFF D P  IY+KI++GK+ FP H    +KDL++ LL VD T+
Sbjct: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280

Query: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
           R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK  G GDTSNF+ Y E D
Sbjct: 281 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 335


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  374 bits (959), Expect = e-104
 Identities = 165/295 (55%), Positives = 225/295 (76%)

Query: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
           L+DF+   T+GTG+FGRV LVK K  + ++A+K++    V++LKQ +H  NEK +L+ V+
Sbjct: 88  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147

Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
            PFL+RL + + D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+   EYLHS
Sbjct: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207

Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
            +++YRDLKPEN+L+D  G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 267

Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
           DWWALG+LI+EM +G+PPFF D P  IY+KI++GK+ FP H    +KDL++ LL VD T+
Sbjct: 268 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 327

Query: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
           R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK  G GDTSNF+ Y E D
Sbjct: 328 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 382


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  371 bits (953), Expect = e-103
 Identities = 165/303 (54%), Positives = 228/303 (75%)

Query: 38  SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
           SP      L  F+ + T+GTG+FGRV LVK K   + +A+K++    V++LKQ +H  NE
Sbjct: 25  SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84

Query: 98  KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
           K +L+ V+ PFL++L +++ D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+
Sbjct: 85  KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144

Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
              EYLHS +++YRDLKPEN+L+D+ G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I 
Sbjct: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 204

Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
           SKG+ +AVDWWALG+LI+EM +G+PPFF D P  IY+KI++GK+ FP H    +KDL++ 
Sbjct: 205 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 264

Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
           LL VD T+R GN+KNG ND+K+H+WF + DW A+ QRK++ P +PK  G GDTSNF+ Y 
Sbjct: 265 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 324

Query: 338 END 340
           E +
Sbjct: 325 EEE 327


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  371 bits (953), Expect = e-103
 Identities = 165/303 (54%), Positives = 228/303 (75%)

Query: 38  SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
           SP      L  F+ + T+GTG+FGRV LVK K   + +A+K++    V++LKQ +H  NE
Sbjct: 33  SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92

Query: 98  KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
           K +L+ V+ PFL++L +++ D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+
Sbjct: 93  KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152

Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
              EYLHS +++YRDLKPEN+L+D+ G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I 
Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212

Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
           SKG+ +AVDWWALG+LI+EM +G+PPFF D P  IY+KI++GK+ FP H    +KDL++ 
Sbjct: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272

Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
           LL VD T+R GN+KNG ND+K+H+WF + DW A+ QRK++ P +PK  G GDTSNF+ Y 
Sbjct: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332

Query: 338 END 340
           E +
Sbjct: 333 EEE 335


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  345 bits (884), Expect = 5e-95
 Identities = 147/303 (48%), Positives = 224/303 (73%)

Query: 38  SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
           +P     S   F+ L T+G G+FGRV LV+ +     +A+K+++   V+++KQ +H+ NE
Sbjct: 33  NPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92

Query: 98  KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
           K +L+ +  PFL++L +++ D  +LY++MEYVPGGE+FS L+  GRFS     FY+A+++
Sbjct: 93  KRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVV 152

Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
            A++YLHS ++++RDLKPEN+L+D+ G++++TDFGFAK++  RTWTLCGTPEYLAPE+I 
Sbjct: 153 LAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212

Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
           SKG+ +AVDWWALG+LI+EM  GFPPF+ D P  IY+KI++G++ FP  L   +K L++ 
Sbjct: 213 SKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRS 272

Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
           LL VD T+R GN++NG  D+K+H+WF +  W A+ ++K++ P +PK  G GD SNF+ Y 
Sbjct: 273 LLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYE 332

Query: 338 END 340
           E +
Sbjct: 333 EEE 335


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score =  292 bits (748), Expect = 3e-79
 Identities = 138/300 (46%), Positives = 208/300 (69%), Gaps = 5/300 (1%)

Query: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKH-FFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
           L DF+ + T+G G FGRV LV+ K+ +   FA+K++    ++  +Q++H+ +EK +++  
Sbjct: 357 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416

Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
              F++RL+ T+ D ++LYMLME   GGEL++ LR+RG F  +T  FY+A ++ A  YLH
Sbjct: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476

Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHG 222
           SK I+YRDLKPEN++LD  G+ KL DFGFAKK+    +TWT CGTPEY+APE+I +KGH 
Sbjct: 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 536

Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLV 280
            + D+W+LGIL++E+L+G PPF   +P   Y  IL G   I+FP+ +  +  +LIKKL  
Sbjct: 537 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 596

Query: 281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
            + + RLGN+KNG  D++ H+WF   +WE + +  L PPI+P +A   DTSNF+++PE++
Sbjct: 597 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 656


>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
           sapiens]
          Length = 686

 Score =  292 bits (748), Expect = 3e-79
 Identities = 138/300 (46%), Positives = 208/300 (69%), Gaps = 5/300 (1%)

Query: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKH-FFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
           L DF+ + T+G G FGRV LV+ K+ +   FA+K++    ++  +Q++H+ +EK +++  
Sbjct: 372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 431

Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
              F++RL+ T+ D ++LYMLME   GGEL++ LR+RG F  +T  FY+A ++ A  YLH
Sbjct: 432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 491

Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHG 222
           SK I+YRDLKPEN++LD  G+ KL DFGFAKK+    +TWT CGTPEY+APE+I +KGH 
Sbjct: 492 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 551

Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLV 280
            + D+W+LGIL++E+L+G PPF   +P   Y  IL G   I+FP+ +  +  +LIKKL  
Sbjct: 552 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 611

Query: 281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
            + + RLGN+KNG  D++ H+WF   +WE + +  L PPI+P +A   DTSNF+++PE++
Sbjct: 612 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 671


>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
          Length = 762

 Score =  285 bits (729), Expect = 4e-77
 Identities = 139/295 (47%), Positives = 199/295 (67%), Gaps = 4/295 (1%)

Query: 47  QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
           Q+ + +AT+G G FGRV LVK K     FA+K +    ++  KQ++HV++EK +L+E+  
Sbjct: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510

Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
           PF+++L+ T+ D +++YML+E   GGEL+S LR+RG F   T  F  A +  A +YLH  
Sbjct: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570

Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHGRA 224
            I+YRDLKPEN++LD +G++KL DFGFAKK+    +TWT CGTPEY+APEVI +KGH  +
Sbjct: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 630

Query: 225 VDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLVVD 282
           VD+W+LGIL++E+L+G PPF   +    Y  IL G  K+DFPR +    +DLI++L   +
Sbjct: 631 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN 690

Query: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
            T RLGN+KNG ND+K HRW    +WE +  R L  P+  ++ G  D S F+ YP
Sbjct: 691 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYP 745


>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
           isoform 3 [Homo sapiens]
          Length = 257

 Score =  278 bits (712), Expect = 4e-75
 Identities = 124/215 (57%), Positives = 169/215 (78%)

Query: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
           L+DF+   T+GTG+FGRV LVK K  + ++A+K++    V++LKQ +H  NEK +L+ V+
Sbjct: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100

Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
            PFL+RL + + D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+   EYLHS
Sbjct: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160

Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
            +++YRDLKPEN+L+D  G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220

Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK 260
           DWWALG+LI+EM +G+PPFF D P  IY+KI++GK
Sbjct: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  255 bits (651), Expect = 5e-68
 Identities = 126/293 (43%), Positives = 184/293 (62%), Gaps = 3/293 (1%)

Query: 45  SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
           ++ DFD L  +G GTFG+V LV+EK +  ++A+K++    +I   +  H   E  VLK  
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203

Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
            HPFL  L +++  +  L  +MEYV GGELF +L     FS     FY AEI+ A++YLH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263

Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGH 221
           S +IVYRDLK EN++LD+DGHIK+TDFG  K+ +    T+   CGTPEYLAPEV++   +
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323

Query: 222 GRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVV 281
           GRAVDWW LG++++EM+ G  PF++ +   +++ IL   I FPR L    K L+  LL+ 
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383

Query: 282 DRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
           D  +RLG   + A ++  H +F  V+W+ V  +KL PP  P++  + DT  F+
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  255 bits (651), Expect = 5e-68
 Identities = 126/293 (43%), Positives = 184/293 (62%), Gaps = 3/293 (1%)

Query: 45  SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
           ++ DFD L  +G GTFG+V LV+EK +  ++A+K++    +I   +  H   E  VLK  
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203

Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
            HPFL  L +++  +  L  +MEYV GGELF +L     FS     FY AEI+ A++YLH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263

Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGH 221
           S +IVYRDLK EN++LD+DGHIK+TDFG  K+ +    T+   CGTPEYLAPEV++   +
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323

Query: 222 GRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVV 281
           GRAVDWW LG++++EM+ G  PF++ +   +++ IL   I FPR L    K L+  LL+ 
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383

Query: 282 DRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
           D  +RLG   + A ++  H +F  V+W+ V  +KL PP  P++  + DT  F+
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  254 bits (650), Expect = 6e-68
 Identities = 127/302 (42%), Positives = 186/302 (61%), Gaps = 3/302 (0%)

Query: 36  ALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVH 95
           A+S      ++ DFD L  +G GTFG+V LV+EK    ++A+K++    +I   +  H  
Sbjct: 139 AVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV 198

Query: 96  NEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAE 155
            E  VL+   HPFL  L + +     L  +MEY  GGELF +L     F+     FY AE
Sbjct: 199 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 258

Query: 156 IICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD---RTWTLCGTPEYLA 212
           I+ A+EYLHS+++VYRD+K EN++LD+DGHIK+TDFG  K+ +       T CGTPEYLA
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLA 318

Query: 213 PEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVK 272
           PEV++   +GRAVDWW LG++++EM+ G  PF++ +   +++ IL  +I FPR L    K
Sbjct: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAK 378

Query: 273 DLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSN 332
            L+  LL  D  +RLG   + A +V  HR+F S++W+ V Q+KL PP  P++  + DT  
Sbjct: 379 SLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRY 438

Query: 333 FE 334
           F+
Sbjct: 439 FD 440


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  250 bits (639), Expect = 1e-66
 Identities = 137/335 (40%), Positives = 197/335 (58%), Gaps = 20/335 (5%)

Query: 19  VAEETPD------GAPALCPSPEA--------LSPEP-PVYSLQDFDTLATVGTGTFGRV 63
           V  E PD       +PA  PSP+         L P   P     DFD L  +G G +G+V
Sbjct: 50  VPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKV 109

Query: 64  HLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFL 122
            L K K+   F+A+KV+    +++ K++ H+  E+SVL K V HPFL+ L +++     L
Sbjct: 110 LLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKL 169

Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDR 182
           Y +++YV GGELF +L+   RF      FY+AE+  AI YLHS  I+YRDLKPENILLD 
Sbjct: 170 YFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDC 229

Query: 183 DGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLS 239
            GH+ LTDFG  K+ V   D T T CGTPEYLAPEV++ + + RAVDWW LG +++EML 
Sbjct: 230 QGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLH 289

Query: 240 GFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKH 299
           G PPF+  +   +Y+ IL   +  P        DL++ LL  D+ +RLG+ K    ++K+
Sbjct: 290 GLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKN 348

Query: 300 HRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
           H +F  ++W+ +  ++L PP  P + G  D  +F+
Sbjct: 349 HVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 383


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  250 bits (638), Expect = 2e-66
 Identities = 133/323 (41%), Positives = 194/323 (60%), Gaps = 14/323 (4%)

Query: 25  DGAPALCPSPEA--------LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFF 75
           + +PA  PSP+         L P   P     DFD L  +G G +G+V L K K+   F+
Sbjct: 2   NSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFY 61

Query: 76  ALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGEL 134
           A+KV+    +++ K++ H+  E+SVL K V HPFL+ L +++     LY +++YV GGEL
Sbjct: 62  AVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGEL 121

Query: 135 FSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA 194
           F +L+   RF      FY+AE+  AI YLHS  I+YRDLKPENILLD  GH+ LTDFG  
Sbjct: 122 FFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC 181

Query: 195 KKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFG 251
           K+ V   D T T CGTPEYLAPEV++ + + RAVDWW LG +++EML G PPF+  +   
Sbjct: 182 KEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQ 241

Query: 252 IYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAV 311
           +Y+ IL   +  P        DL++ LL  D+ +RLG+ K    ++K+H +F  ++W+ +
Sbjct: 242 MYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDL 300

Query: 312 PQRKLKPPIVPKIAGDGDTSNFE 334
             ++L PP  P + G  D  +F+
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFD 323


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  248 bits (634), Expect = 5e-66
 Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)

Query: 3   APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
           A GL +    E D R  +     GA  +  S   L+      ++ +F+ L  +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163

Query: 63  VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
           V LVKEK    ++A+K++    ++   +  H   E  VL+   HPFL  L +++     L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223

Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
             +MEY  GGELF +L     FS     FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283

Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
           +DGHIK+TDFG  K+ +    T+   CGTPEYLAPEV++   +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343

Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
            G  PF++ +   +++ IL  +I FPR L    K L+  LL  D  +RLG     A ++ 
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403

Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
            HR+F  + W+ V ++KL PP  P++  + DT  F+        T  P  Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  248 bits (634), Expect = 5e-66
 Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)

Query: 3   APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
           A GL +    E D R  +     GA  +  S   L+      ++ +F+ L  +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163

Query: 63  VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
           V LVKEK    ++A+K++    ++   +  H   E  VL+   HPFL  L +++     L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223

Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
             +MEY  GGELF +L     FS     FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283

Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
           +DGHIK+TDFG  K+ +    T+   CGTPEYLAPEV++   +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343

Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
            G  PF++ +   +++ IL  +I FPR L    K L+  LL  D  +RLG     A ++ 
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403

Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
            HR+F  + W+ V ++KL PP  P++  + DT  F+        T  P  Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  248 bits (634), Expect = 5e-66
 Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)

Query: 3   APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
           A GL +    E D R  +     GA  +  S   L+      ++ +F+ L  +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163

Query: 63  VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
           V LVKEK    ++A+K++    ++   +  H   E  VL+   HPFL  L +++     L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223

Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
             +MEY  GGELF +L     FS     FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283

Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
           +DGHIK+TDFG  K+ +    T+   CGTPEYLAPEV++   +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343

Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
            G  PF++ +   +++ IL  +I FPR L    K L+  LL  D  +RLG     A ++ 
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403

Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
            HR+F  + W+ V ++KL PP  P++  + DT  F+        T  P  Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  247 bits (631), Expect = 1e-65
 Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)

Query: 22  ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
           E  +  P+  PSP     L P   P     DF  L  +G G+FG+V L + K  + F+A+
Sbjct: 67  ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 126

Query: 78  KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
           KV+    +++ K+E+H+ +E++VL K V HPFL+ L +++     LY +++Y+ GGELF 
Sbjct: 127 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 186

Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
           +L+    F      FY+AEI  A+ YLHS  IVYRDLKPENILLD  GHI LTDFG  K+
Sbjct: 187 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 246

Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
            ++    T T CGTPEYLAPEV+  + + R VDWW LG +++EML G PPF+  N   +Y
Sbjct: 247 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 306

Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
             IL   +    ++    + L++ LL  DRT+RLG  K+   ++K H +F  ++W+ +  
Sbjct: 307 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 365

Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
           +K+ PP  P ++G  D  +F+  PE    T  PVP
Sbjct: 366 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 395


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  247 bits (631), Expect = 1e-65
 Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)

Query: 22  ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
           E  +  P+  PSP     L P   P     DF  L  +G G+FG+V L + K  + F+A+
Sbjct: 81  ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 140

Query: 78  KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
           KV+    +++ K+E+H+ +E++VL K V HPFL+ L +++     LY +++Y+ GGELF 
Sbjct: 141 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 200

Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
           +L+    F      FY+AEI  A+ YLHS  IVYRDLKPENILLD  GHI LTDFG  K+
Sbjct: 201 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 260

Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
            ++    T T CGTPEYLAPEV+  + + R VDWW LG +++EML G PPF+  N   +Y
Sbjct: 261 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 320

Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
             IL   +    ++    + L++ LL  DRT+RLG  K+   ++K H +F  ++W+ +  
Sbjct: 321 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 379

Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
           +K+ PP  P ++G  D  +F+  PE    T  PVP
Sbjct: 380 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 409


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  247 bits (631), Expect = 1e-65
 Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)

Query: 22  ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
           E  +  P+  PSP     L P   P     DF  L  +G G+FG+V L + K  + F+A+
Sbjct: 95  ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 154

Query: 78  KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
           KV+    +++ K+E+H+ +E++VL K V HPFL+ L +++     LY +++Y+ GGELF 
Sbjct: 155 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 214

Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
           +L+    F      FY+AEI  A+ YLHS  IVYRDLKPENILLD  GHI LTDFG  K+
Sbjct: 215 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 274

Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
            ++    T T CGTPEYLAPEV+  + + R VDWW LG +++EML G PPF+  N   +Y
Sbjct: 275 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 334

Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
             IL   +    ++    + L++ LL  DRT+RLG  K+   ++K H +F  ++W+ +  
Sbjct: 335 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 393

Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
           +K+ PP  P ++G  D  +F+  PE    T  PVP
Sbjct: 394 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 423


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  247 bits (631), Expect = 1e-65
 Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)

Query: 22  ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
           E  +  P+  PSP     L P   P     DF  L  +G G+FG+V L + K  + F+A+
Sbjct: 162 ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 221

Query: 78  KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
           KV+    +++ K+E+H+ +E++VL K V HPFL+ L +++     LY +++Y+ GGELF 
Sbjct: 222 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 281

Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
           +L+    F      FY+AEI  A+ YLHS  IVYRDLKPENILLD  GHI LTDFG  K+
Sbjct: 282 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 341

Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
            ++    T T CGTPEYLAPEV+  + + R VDWW LG +++EML G PPF+  N   +Y
Sbjct: 342 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 401

Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
             IL   +    ++    + L++ LL  DRT+RLG  K+   ++K H +F  ++W+ +  
Sbjct: 402 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 460

Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
           +K+ PP  P ++G  D  +F+  PE    T  PVP
Sbjct: 461 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 490


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  246 bits (627), Expect = 3e-65
 Identities = 127/309 (41%), Positives = 186/309 (60%), Gaps = 14/309 (4%)

Query: 34  PEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKH---FFALKVMSIPDVIR-LK 89
           PE + PE        F+ L  +G G +G+V  V++ T  +    FA+KV+    ++R  K
Sbjct: 83  PEKIRPEC-------FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135

Query: 90  QEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTG 149
              H   E+++L+EV HPF++ L + +     LY+++EY+ GGELF  L   G F   T 
Sbjct: 136 DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTA 195

Query: 150 LFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR---TWTLCG 206
            FY AEI  A+ +LH K I+YRDLKPENI+L+  GH+KLTDFG  K+ +     T T CG
Sbjct: 196 CFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCG 255

Query: 207 TPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRH 266
           T EY+APE++   GH RAVDWW+LG L+++ML+G PPF  +N      KIL  K++ P +
Sbjct: 256 TIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPY 315

Query: 267 LDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAG 326
           L    +DL+KKLL  +   RLG     A +V+ H +FR ++WE +  RK++PP  P +  
Sbjct: 316 LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQS 375

Query: 327 DGDTSNFET 335
           + D S F++
Sbjct: 376 EEDVSQFDS 384


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  242 bits (618), Expect = 3e-64
 Identities = 125/292 (42%), Positives = 180/292 (61%), Gaps = 5/292 (1%)

Query: 48  DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSH 106
           DFD L  +G G+FG+V L K K    F+A+KV+    V+  K+++H+  E++VL K V H
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
           PFL+ L +++     LY ++++V GGELF +L+    F      FY+AEI  A+ YLHS 
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKK---LVDRTWTLCGTPEYLAPEVIQSKGHGR 223
           +IVYRDLKPENILLD  GH+ LTDFG  K+   + D T T CGTPEYLAPEVI+ + +  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 224 AVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDR 283
            VDWW LG +++EML G PPF+  +   +Y  IL   +     +      ++++LL  DR
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400

Query: 284 TRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
             RLG  K    ++++H +F S+ W  + Q+K+ PP  P +AG  D  NF+T
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  242 bits (618), Expect = 3e-64
 Identities = 125/292 (42%), Positives = 180/292 (61%), Gaps = 5/292 (1%)

Query: 48  DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSH 106
           DFD L  +G G+FG+V L K K    F+A+KV+    V+  K+++H+  E++VL K V H
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
           PFL+ L +++     LY ++++V GGELF +L+    F      FY+AEI  A+ YLHS 
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKK---LVDRTWTLCGTPEYLAPEVIQSKGHGR 223
           +IVYRDLKPENILLD  GH+ LTDFG  K+   + D T T CGTPEYLAPEVI+ + +  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 224 AVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDR 283
            VDWW LG +++EML G PPF+  +   +Y  IL   +     +      ++++LL  DR
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400

Query: 284 TRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
             RLG  K    ++++H +F S+ W  + Q+K+ PP  P +AG  D  NF+T
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  236 bits (601), Expect = 3e-62
 Identities = 123/331 (37%), Positives = 195/331 (58%), Gaps = 21/331 (6%)

Query: 44  YSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKE 103
           ++LQDF   A +G G FG+V L + K     FA+K +   D++   +   +  EK + + 
Sbjct: 652 FNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 711

Query: 104 VS---HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAI 160
           V+   HPFL+ LF  +  +  +  +MEY  GG+L  ++     FS    +FY+A ++  +
Sbjct: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGL 770

Query: 161 EYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQ 217
           +YLH  +IVYRDLK +N+LLD +G +K+ DFG  K+ +   DRT T CGTPE+LAPEV+ 
Sbjct: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830

Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
              + RAVDWW LG+LI+EML G  PF  D+   ++  I+  ++ +PR L      ++++
Sbjct: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890

Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
           LL  +  RRLG  +  A DVK H +FR +DW A+  +K+KPP +P I G  D SNF    
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF---- 946

Query: 338 ENDWDTAAPV----------PQKDLEIFKNF 358
           ++++ + AP+           +++ E+F++F
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDF 977


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  236 bits (601), Expect = 3e-62
 Identities = 131/351 (37%), Positives = 206/351 (58%), Gaps = 13/351 (3%)

Query: 3   APGLAQAAAAESDSRKVAEETPDG-APALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
           +P    +   ES + ++  ET +   PALC SP   SP     +L+DF  LA +G G FG
Sbjct: 579 SPSSLSSPIQESTAPELPSETQETPGPALC-SPLRKSP----LTLEDFKFLAVLGRGHFG 633

Query: 62  RVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS---HPFLIRLFWTWHD 118
           +V L + + +   FA+K +   D++   + + +  EK +L  V+   HPFL+ LF  +  
Sbjct: 634 KVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQT 693

Query: 119 ERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 178
              +  +MEY  GG+L  ++ +   FS    +FYSA ++  +++LH  +IVYRDLK +N+
Sbjct: 694 PEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNL 752

Query: 179 LLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIF 235
           LLD +G++K+ DFG  K+ +   DRT T CGTPE+LAPEV+    + RAVDWW LG+L++
Sbjct: 753 LLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLY 812

Query: 236 EMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGAN 295
           EML G  PF  D+   ++  I+  ++ +PR L      ++++LL  +  RRLG+ +  A 
Sbjct: 813 EMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAE 872

Query: 296 DVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAP 346
           DVK   +FR++ WEA+  R+L PP VP ++G  D SNF+     +  T +P
Sbjct: 873 DVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 923


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  236 bits (601), Expect = 3e-62
 Identities = 131/351 (37%), Positives = 206/351 (58%), Gaps = 13/351 (3%)

Query: 3   APGLAQAAAAESDSRKVAEETPDG-APALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
           +P    +   ES + ++  ET +   PALC SP   SP     +L+DF  LA +G G FG
Sbjct: 573 SPSSLSSPIQESTAPELPSETQETPGPALC-SPLRKSP----LTLEDFKFLAVLGRGHFG 627

Query: 62  RVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS---HPFLIRLFWTWHD 118
           +V L + + +   FA+K +   D++   + + +  EK +L  V+   HPFL+ LF  +  
Sbjct: 628 KVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQT 687

Query: 119 ERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 178
              +  +MEY  GG+L  ++ +   FS    +FYSA ++  +++LH  +IVYRDLK +N+
Sbjct: 688 PEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNL 746

Query: 179 LLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIF 235
           LLD +G++K+ DFG  K+ +   DRT T CGTPE+LAPEV+    + RAVDWW LG+L++
Sbjct: 747 LLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLY 806

Query: 236 EMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGAN 295
           EML G  PF  D+   ++  I+  ++ +PR L      ++++LL  +  RRLG+ +  A 
Sbjct: 807 EMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAE 866

Query: 296 DVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAP 346
           DVK   +FR++ WEA+  R+L PP VP ++G  D SNF+     +  T +P
Sbjct: 867 DVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 917


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  233 bits (595), Expect = 2e-61
 Identities = 127/341 (37%), Positives = 195/341 (57%), Gaps = 14/341 (4%)

Query: 2   EAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
           +A  LA+  AA  +     EE      ++   PE + P         F+ L  +G G +G
Sbjct: 27  DACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHC-------FELLRVLGKGGYG 79

Query: 62  RVHLVKEKTAKHF---FALKVMSIPDVIR-LKQEQHVHNEKSVLKEVSHPFLIRLFWTWH 117
           +V  V++    +    +A+KV+    ++R  K   H   E+++L+ V HPF++ L + + 
Sbjct: 80  KVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQ 139

Query: 118 DERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPEN 177
               LY+++E + GGELF++L   G F   T  FY AEI  A+ +LHS+ I+YRDLKPEN
Sbjct: 140 TGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPEN 199

Query: 178 ILLDRDGHIKLTDFGFAKKLVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILI 234
           I+L   GHIKLTDFG  K+ +     T T CGT EY+APE++   GH RAVDWW+LG L+
Sbjct: 200 IMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALM 259

Query: 235 FEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGA 294
           ++ML+G PPF  +N      KI+ GK+  P +L    +DL+KK L  + ++R+G     A
Sbjct: 260 YDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDA 319

Query: 295 NDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
            DV+ H +FR ++W+ +   ++ PP  P +  + D S F+T
Sbjct: 320 ADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT 360


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  231 bits (588), Expect = 1e-60
 Identities = 110/293 (37%), Positives = 183/293 (62%), Gaps = 7/293 (2%)

Query: 49  FDTLATVGTGTFGRVHLVKEKT---AKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
           F+ L  +G G+FG+V LV++ T   + H +A+KV+     ++++       E+ +L +V+
Sbjct: 71  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLK-KATLKVRDRVRTKMERDILADVN 129

Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
           HPF+++L + +  E  LY++++++ GG+LF+ L     F+     FY AE+   +++LHS
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189

Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD---RTWTLCGTPEYLAPEVIQSKGHG 222
             I+YRDLKPENILLD +GHIKLTDFG +K+ +D   + ++ CGT EY+APEV+  +GH 
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 249

Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVD 282
            + DWW+ G+L+FEML+G  PF   +       IL  K+  P+ L    + L++ L   +
Sbjct: 250 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 309

Query: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
              RLG+  +GA ++K H ++ ++DW  + +R++KPP  P +A   DT  F+T
Sbjct: 310 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 362



 Score =  122 bits (307), Expect = 4e-28
 Identities = 90/278 (32%), Positives = 138/278 (49%), Gaps = 29/278 (10%)

Query: 54  TVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS-HPFLIRL 112
           T+G G++        K     +A+KV+        K ++    E  +L     HP +I L
Sbjct: 432 TIGVGSYSECKRCVHKATNMEYAVKVID-------KSKRDPSEEIEILLRYGQHPNIITL 484

Query: 113 FWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRD 172
              + D + +Y++ E + GGEL   +  +  FS     F    I   +EYLHS+ +V+RD
Sbjct: 485 KDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD 544

Query: 173 LKPENIL-LDRDGH---IKLTDFGFAKKLVDRT---WTLCGTPEYLAPEVIQSKGHGRAV 225
           LKP NIL +D  G+   +++ DFGFAK+L        T C T  ++APEV++ +G+    
Sbjct: 545 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGC 604

Query: 226 DWWALGILIFEMLSGFPPFFD---DNPFGIYQKILAGKIDFP----RHLDFHVKDLIKKL 278
           D W+LGIL++ ML+G+ PF +   D P  I  +I +GK          +    KDL+ K+
Sbjct: 605 DIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKM 664

Query: 279 LVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKL 316
           L VD  +RL      A  V  H W    D   +PQ +L
Sbjct: 665 LHVDPHQRL-----TAKQVLQHPWVTQKD--KLPQSQL 695


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,581,826
Number of Sequences: 37866
Number of extensions: 769496
Number of successful extensions: 4537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 751
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2129
Number of HSP's gapped (non-prelim): 983
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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