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Search of human proteins with 4826948
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826948 protein kinase, X-linked [Homo sapiens]
(358 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826948 protein kinase, X-linked [Homo sapiens] 744 0.0
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 374 e-104
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 374 e-104
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 371 e-103
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 371 e-103
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 345 5e-95
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 292 3e-79
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 292 3e-79
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 285 4e-77
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 278 4e-75
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 255 5e-68
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 255 5e-68
gi|4502023 AKT2 kinase [Homo sapiens] 254 6e-68
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 250 1e-66
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 250 2e-66
gi|62241015 AKT1 kinase [Homo sapiens] 248 5e-66
gi|62241013 AKT1 kinase [Homo sapiens] 248 5e-66
gi|62241011 AKT1 kinase [Homo sapiens] 248 5e-66
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 247 1e-65
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 247 1e-65
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 247 1e-65
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 247 1e-65
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 246 3e-65
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 242 3e-64
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 242 3e-64
gi|5453974 protein kinase N2 [Homo sapiens] 236 3e-62
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 236 3e-62
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 236 3e-62
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 233 2e-61
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 231 1e-60
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 744 bits (1920), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF 60
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF
Sbjct: 1 MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF 60
Query: 61 GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER 120
GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER
Sbjct: 61 GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER 120
Query: 121 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL 180
FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL
Sbjct: 121 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL 180
Query: 181 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG 240
DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG
Sbjct: 181 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG 240
Query: 241 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH 300
FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH
Sbjct: 241 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH 300
Query: 301 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 358
RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
Sbjct: 301 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 358
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 374 bits (959), Expect = e-104
Identities = 165/295 (55%), Positives = 225/295 (76%)
Query: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
L+DF+ T+GTG+FGRV LVK K + ++A+K++ V++LKQ +H NEK +L+ V+
Sbjct: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
PFL+RL + + D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+ EYLHS
Sbjct: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
+++YRDLKPEN+L+D G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220
Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
DWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++ LL VD T+
Sbjct: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280
Query: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y E D
Sbjct: 281 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 335
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 374 bits (959), Expect = e-104
Identities = 165/295 (55%), Positives = 225/295 (76%)
Query: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
L+DF+ T+GTG+FGRV LVK K + ++A+K++ V++LKQ +H NEK +L+ V+
Sbjct: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
PFL+RL + + D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+ EYLHS
Sbjct: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207
Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
+++YRDLKPEN+L+D G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 267
Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
DWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++ LL VD T+
Sbjct: 268 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 327
Query: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y E D
Sbjct: 328 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 382
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 371 bits (953), Expect = e-103
Identities = 165/303 (54%), Positives = 228/303 (75%)
Query: 38 SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
SP L F+ + T+GTG+FGRV LVK K + +A+K++ V++LKQ +H NE
Sbjct: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
Query: 98 KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
K +L+ V+ PFL++L +++ D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+
Sbjct: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
EYLHS +++YRDLKPEN+L+D+ G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I
Sbjct: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 204
Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
SKG+ +AVDWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++
Sbjct: 205 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 264
Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
LL VD T+R GN+KNG ND+K+H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y
Sbjct: 265 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 324
Query: 338 END 340
E +
Sbjct: 325 EEE 327
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 371 bits (953), Expect = e-103
Identities = 165/303 (54%), Positives = 228/303 (75%)
Query: 38 SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
SP L F+ + T+GTG+FGRV LVK K + +A+K++ V++LKQ +H NE
Sbjct: 33 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92
Query: 98 KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
K +L+ V+ PFL++L +++ D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+
Sbjct: 93 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152
Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
EYLHS +++YRDLKPEN+L+D+ G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I
Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212
Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
SKG+ +AVDWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++
Sbjct: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272
Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
LL VD T+R GN+KNG ND+K+H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y
Sbjct: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332
Query: 338 END 340
E +
Sbjct: 333 EEE 335
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 345 bits (884), Expect = 5e-95
Identities = 147/303 (48%), Positives = 224/303 (73%)
Query: 38 SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
+P S F+ L T+G G+FGRV LV+ + +A+K+++ V+++KQ +H+ NE
Sbjct: 33 NPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
Query: 98 KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
K +L+ + PFL++L +++ D +LY++MEYVPGGE+FS L+ GRFS FY+A+++
Sbjct: 93 KRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVV 152
Query: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
A++YLHS ++++RDLKPEN+L+D+ G++++TDFGFAK++ RTWTLCGTPEYLAPE+I
Sbjct: 153 LAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212
Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
SKG+ +AVDWWALG+LI+EM GFPPF+ D P IY+KI++G++ FP L +K L++
Sbjct: 213 SKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRS 272
Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
LL VD T+R GN++NG D+K+H+WF + W A+ ++K++ P +PK G GD SNF+ Y
Sbjct: 273 LLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYE 332
Query: 338 END 340
E +
Sbjct: 333 EEE 335
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 292 bits (748), Expect = 3e-79
Identities = 138/300 (46%), Positives = 208/300 (69%), Gaps = 5/300 (1%)
Query: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKH-FFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
L DF+ + T+G G FGRV LV+ K+ + FA+K++ ++ +Q++H+ +EK +++
Sbjct: 357 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
F++RL+ T+ D ++LYMLME GGEL++ LR+RG F +T FY+A ++ A YLH
Sbjct: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHG 222
SK I+YRDLKPEN++LD G+ KL DFGFAKK+ +TWT CGTPEY+APE+I +KGH
Sbjct: 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 536
Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLV 280
+ D+W+LGIL++E+L+G PPF +P Y IL G I+FP+ + + +LIKKL
Sbjct: 537 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 596
Query: 281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
+ + RLGN+KNG D++ H+WF +WE + + L PPI+P +A DTSNF+++PE++
Sbjct: 597 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 656
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 292 bits (748), Expect = 3e-79
Identities = 138/300 (46%), Positives = 208/300 (69%), Gaps = 5/300 (1%)
Query: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKH-FFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
L DF+ + T+G G FGRV LV+ K+ + FA+K++ ++ +Q++H+ +EK +++
Sbjct: 372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 431
Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
F++RL+ T+ D ++LYMLME GGEL++ LR+RG F +T FY+A ++ A YLH
Sbjct: 432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 491
Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHG 222
SK I+YRDLKPEN++LD G+ KL DFGFAKK+ +TWT CGTPEY+APE+I +KGH
Sbjct: 492 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 551
Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLV 280
+ D+W+LGIL++E+L+G PPF +P Y IL G I+FP+ + + +LIKKL
Sbjct: 552 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 611
Query: 281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
+ + RLGN+KNG D++ H+WF +WE + + L PPI+P +A DTSNF+++PE++
Sbjct: 612 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 671
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 285 bits (729), Expect = 4e-77
Identities = 139/295 (47%), Positives = 199/295 (67%), Gaps = 4/295 (1%)
Query: 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Q+ + +AT+G G FGRV LVK K FA+K + ++ KQ++HV++EK +L+E+
Sbjct: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
PF+++L+ T+ D +++YML+E GGEL+S LR+RG F T F A + A +YLH
Sbjct: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570
Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHGRA 224
I+YRDLKPEN++LD +G++KL DFGFAKK+ +TWT CGTPEY+APEVI +KGH +
Sbjct: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 630
Query: 225 VDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLVVD 282
VD+W+LGIL++E+L+G PPF + Y IL G K+DFPR + +DLI++L +
Sbjct: 631 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN 690
Query: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
T RLGN+KNG ND+K HRW +WE + R L P+ ++ G D S F+ YP
Sbjct: 691 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYP 745
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 278 bits (712), Expect = 4e-75
Identities = 124/215 (57%), Positives = 169/215 (78%)
Query: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
L+DF+ T+GTG+FGRV LVK K + ++A+K++ V++LKQ +H NEK +L+ V+
Sbjct: 41 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
PFL+RL + + D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+ EYLHS
Sbjct: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
+++YRDLKPEN+L+D G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220
Query: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK 260
DWWALG+LI+EM +G+PPFF D P IY+KI++GK
Sbjct: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 255 bits (651), Expect = 5e-68
Identities = 126/293 (43%), Positives = 184/293 (62%), Gaps = 3/293 (1%)
Query: 45 SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
++ DFD L +G GTFG+V LV+EK + ++A+K++ +I + H E VLK
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
HPFL L +++ + L +MEYV GGELF +L FS FY AEI+ A++YLH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGH 221
S +IVYRDLK EN++LD+DGHIK+TDFG K+ + T+ CGTPEYLAPEV++ +
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 222 GRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVV 281
GRAVDWW LG++++EM+ G PF++ + +++ IL I FPR L K L+ LL+
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383
Query: 282 DRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
D +RLG + A ++ H +F V+W+ V +KL PP P++ + DT F+
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 255 bits (651), Expect = 5e-68
Identities = 126/293 (43%), Positives = 184/293 (62%), Gaps = 3/293 (1%)
Query: 45 SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
++ DFD L +G GTFG+V LV+EK + ++A+K++ +I + H E VLK
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
HPFL L +++ + L +MEYV GGELF +L FS FY AEI+ A++YLH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGH 221
S +IVYRDLK EN++LD+DGHIK+TDFG K+ + T+ CGTPEYLAPEV++ +
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 222 GRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVV 281
GRAVDWW LG++++EM+ G PF++ + +++ IL I FPR L K L+ LL+
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383
Query: 282 DRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
D +RLG + A ++ H +F V+W+ V +KL PP P++ + DT F+
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 254 bits (650), Expect = 6e-68
Identities = 127/302 (42%), Positives = 186/302 (61%), Gaps = 3/302 (0%)
Query: 36 ALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVH 95
A+S ++ DFD L +G GTFG+V LV+EK ++A+K++ +I + H
Sbjct: 139 AVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV 198
Query: 96 NEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAE 155
E VL+ HPFL L + + L +MEY GGELF +L F+ FY AE
Sbjct: 199 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 258
Query: 156 IICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD---RTWTLCGTPEYLA 212
I+ A+EYLHS+++VYRD+K EN++LD+DGHIK+TDFG K+ + T CGTPEYLA
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLA 318
Query: 213 PEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVK 272
PEV++ +GRAVDWW LG++++EM+ G PF++ + +++ IL +I FPR L K
Sbjct: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAK 378
Query: 273 DLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSN 332
L+ LL D +RLG + A +V HR+F S++W+ V Q+KL PP P++ + DT
Sbjct: 379 SLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRY 438
Query: 333 FE 334
F+
Sbjct: 439 FD 440
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 250 bits (639), Expect = 1e-66
Identities = 137/335 (40%), Positives = 197/335 (58%), Gaps = 20/335 (5%)
Query: 19 VAEETPD------GAPALCPSPEA--------LSPEP-PVYSLQDFDTLATVGTGTFGRV 63
V E PD +PA PSP+ L P P DFD L +G G +G+V
Sbjct: 50 VPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKV 109
Query: 64 HLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFL 122
L K K+ F+A+KV+ +++ K++ H+ E+SVL K V HPFL+ L +++ L
Sbjct: 110 LLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKL 169
Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDR 182
Y +++YV GGELF +L+ RF FY+AE+ AI YLHS I+YRDLKPENILLD
Sbjct: 170 YFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDC 229
Query: 183 DGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLS 239
GH+ LTDFG K+ V D T T CGTPEYLAPEV++ + + RAVDWW LG +++EML
Sbjct: 230 QGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLH 289
Query: 240 GFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKH 299
G PPF+ + +Y+ IL + P DL++ LL D+ +RLG+ K ++K+
Sbjct: 290 GLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKN 348
Query: 300 HRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
H +F ++W+ + ++L PP P + G D +F+
Sbjct: 349 HVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 383
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 250 bits (638), Expect = 2e-66
Identities = 133/323 (41%), Positives = 194/323 (60%), Gaps = 14/323 (4%)
Query: 25 DGAPALCPSPEA--------LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFF 75
+ +PA PSP+ L P P DFD L +G G +G+V L K K+ F+
Sbjct: 2 NSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFY 61
Query: 76 ALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGEL 134
A+KV+ +++ K++ H+ E+SVL K V HPFL+ L +++ LY +++YV GGEL
Sbjct: 62 AVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGEL 121
Query: 135 FSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA 194
F +L+ RF FY+AE+ AI YLHS I+YRDLKPENILLD GH+ LTDFG
Sbjct: 122 FFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC 181
Query: 195 KKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFG 251
K+ V D T T CGTPEYLAPEV++ + + RAVDWW LG +++EML G PPF+ +
Sbjct: 182 KEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQ 241
Query: 252 IYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAV 311
+Y+ IL + P DL++ LL D+ +RLG+ K ++K+H +F ++W+ +
Sbjct: 242 MYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDL 300
Query: 312 PQRKLKPPIVPKIAGDGDTSNFE 334
++L PP P + G D +F+
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFD 323
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 248 bits (634), Expect = 5e-66
Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)
Query: 3 APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
A GL + E D R + GA + S L+ ++ +F+ L +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 63 VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
V LVKEK ++A+K++ ++ + H E VL+ HPFL L +++ L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
+MEY GGELF +L FS FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
+DGHIK+TDFG K+ + T+ CGTPEYLAPEV++ +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343
Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
G PF++ + +++ IL +I FPR L K L+ LL D +RLG A ++
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403
Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
HR+F + W+ V ++KL PP P++ + DT F+ T P Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 248 bits (634), Expect = 5e-66
Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)
Query: 3 APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
A GL + E D R + GA + S L+ ++ +F+ L +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 63 VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
V LVKEK ++A+K++ ++ + H E VL+ HPFL L +++ L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
+MEY GGELF +L FS FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
+DGHIK+TDFG K+ + T+ CGTPEYLAPEV++ +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343
Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
G PF++ + +++ IL +I FPR L K L+ LL D +RLG A ++
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403
Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
HR+F + W+ V ++KL PP P++ + DT F+ T P Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 248 bits (634), Expect = 5e-66
Identities = 136/353 (38%), Positives = 199/353 (56%), Gaps = 7/353 (1%)
Query: 3 APGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGR 62
A GL + E D R + GA + S L+ ++ +F+ L +G GTFG+
Sbjct: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVS---LAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 63 VHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFL 122
V LVKEK ++A+K++ ++ + H E VL+ HPFL L +++ L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 123 YMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD 181
+MEY GGELF +L FS FY AEI+ A++YLHS K +VYRDLK EN++LD
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 182 RDGHIKLTDFGFAKKLVDRTWTL---CGTPEYLAPEVIQSKGHGRAVDWWALGILIFEML 238
+DGHIK+TDFG K+ + T+ CGTPEYLAPEV++ +GRAVDWW LG++++EM+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343
Query: 239 SGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVK 298
G PF++ + +++ IL +I FPR L K L+ LL D +RLG A ++
Sbjct: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403
Query: 299 HHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKD 351
HR+F + W+ V ++KL PP P++ + DT F+ T P Q D
Sbjct: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 247 bits (631), Expect = 1e-65
Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)
Query: 22 ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
E + P+ PSP L P P DF L +G G+FG+V L + K + F+A+
Sbjct: 67 ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 126
Query: 78 KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
KV+ +++ K+E+H+ +E++VL K V HPFL+ L +++ LY +++Y+ GGELF
Sbjct: 127 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 186
Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
+L+ F FY+AEI A+ YLHS IVYRDLKPENILLD GHI LTDFG K+
Sbjct: 187 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 246
Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
++ T T CGTPEYLAPEV+ + + R VDWW LG +++EML G PPF+ N +Y
Sbjct: 247 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 306
Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
IL + ++ + L++ LL DRT+RLG K+ ++K H +F ++W+ +
Sbjct: 307 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 365
Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
+K+ PP P ++G D +F+ PE T PVP
Sbjct: 366 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 395
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 247 bits (631), Expect = 1e-65
Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)
Query: 22 ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
E + P+ PSP L P P DF L +G G+FG+V L + K + F+A+
Sbjct: 81 ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 140
Query: 78 KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
KV+ +++ K+E+H+ +E++VL K V HPFL+ L +++ LY +++Y+ GGELF
Sbjct: 141 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 200
Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
+L+ F FY+AEI A+ YLHS IVYRDLKPENILLD GHI LTDFG K+
Sbjct: 201 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 260
Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
++ T T CGTPEYLAPEV+ + + R VDWW LG +++EML G PPF+ N +Y
Sbjct: 261 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 320
Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
IL + ++ + L++ LL DRT+RLG K+ ++K H +F ++W+ +
Sbjct: 321 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 379
Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
+K+ PP P ++G D +F+ PE T PVP
Sbjct: 380 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 409
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 247 bits (631), Expect = 1e-65
Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)
Query: 22 ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
E + P+ PSP L P P DF L +G G+FG+V L + K + F+A+
Sbjct: 95 ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 154
Query: 78 KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
KV+ +++ K+E+H+ +E++VL K V HPFL+ L +++ LY +++Y+ GGELF
Sbjct: 155 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 214
Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
+L+ F FY+AEI A+ YLHS IVYRDLKPENILLD GHI LTDFG K+
Sbjct: 215 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 274
Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
++ T T CGTPEYLAPEV+ + + R VDWW LG +++EML G PPF+ N +Y
Sbjct: 275 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 334
Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
IL + ++ + L++ LL DRT+RLG K+ ++K H +F ++W+ +
Sbjct: 335 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 393
Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
+K+ PP P ++G D +F+ PE T PVP
Sbjct: 394 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 423
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 247 bits (631), Expect = 1e-65
Identities = 136/335 (40%), Positives = 199/335 (59%), Gaps = 14/335 (4%)
Query: 22 ETPDGAPALCPSPEA---LSPEP-PVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77
E + P+ PSP L P P DF L +G G+FG+V L + K + F+A+
Sbjct: 162 ELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAV 221
Query: 78 KVMSIPDVIRLKQEQHVHNEKSVL-KEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFS 136
KV+ +++ K+E+H+ +E++VL K V HPFL+ L +++ LY +++Y+ GGELF
Sbjct: 222 KVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFY 281
Query: 137 YLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKK 196
+L+ F FY+AEI A+ YLHS IVYRDLKPENILLD GHI LTDFG K+
Sbjct: 282 HLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 341
Query: 197 LVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
++ T T CGTPEYLAPEV+ + + R VDWW LG +++EML G PPF+ N +Y
Sbjct: 342 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY 401
Query: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQ 313
IL + ++ + L++ LL DRT+RLG K+ ++K H +F ++W+ +
Sbjct: 402 DNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLIN 460
Query: 314 RKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVP 348
+K+ PP P ++G D +F+ PE T PVP
Sbjct: 461 KKITPPFNPNVSGPNDLRHFD--PE---FTEEPVP 490
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 246 bits (627), Expect = 3e-65
Identities = 127/309 (41%), Positives = 186/309 (60%), Gaps = 14/309 (4%)
Query: 34 PEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKH---FFALKVMSIPDVIR-LK 89
PE + PE F+ L +G G +G+V V++ T + FA+KV+ ++R K
Sbjct: 83 PEKIRPEC-------FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
Query: 90 QEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTG 149
H E+++L+EV HPF++ L + + LY+++EY+ GGELF L G F T
Sbjct: 136 DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTA 195
Query: 150 LFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR---TWTLCG 206
FY AEI A+ +LH K I+YRDLKPENI+L+ GH+KLTDFG K+ + T T CG
Sbjct: 196 CFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCG 255
Query: 207 TPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRH 266
T EY+APE++ GH RAVDWW+LG L+++ML+G PPF +N KIL K++ P +
Sbjct: 256 TIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPY 315
Query: 267 LDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAG 326
L +DL+KKLL + RLG A +V+ H +FR ++WE + RK++PP P +
Sbjct: 316 LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQS 375
Query: 327 DGDTSNFET 335
+ D S F++
Sbjct: 376 EEDVSQFDS 384
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 242 bits (618), Expect = 3e-64
Identities = 125/292 (42%), Positives = 180/292 (61%), Gaps = 5/292 (1%)
Query: 48 DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSH 106
DFD L +G G+FG+V L K K F+A+KV+ V+ K+++H+ E++VL K V H
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
PFL+ L +++ LY ++++V GGELF +L+ F FY+AEI A+ YLHS
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKK---LVDRTWTLCGTPEYLAPEVIQSKGHGR 223
+IVYRDLKPENILLD GH+ LTDFG K+ + D T T CGTPEYLAPEVI+ + +
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 224 AVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDR 283
VDWW LG +++EML G PPF+ + +Y IL + + ++++LL DR
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 284 TRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
RLG K ++++H +F S+ W + Q+K+ PP P +AG D NF+T
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 242 bits (618), Expect = 3e-64
Identities = 125/292 (42%), Positives = 180/292 (61%), Gaps = 5/292 (1%)
Query: 48 DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVL-KEVSH 106
DFD L +G G+FG+V L K K F+A+KV+ V+ K+++H+ E++VL K V H
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
PFL+ L +++ LY ++++V GGELF +L+ F FY+AEI A+ YLHS
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKK---LVDRTWTLCGTPEYLAPEVIQSKGHGR 223
+IVYRDLKPENILLD GH+ LTDFG K+ + D T T CGTPEYLAPEVI+ + +
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 224 AVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDR 283
VDWW LG +++EML G PPF+ + +Y IL + + ++++LL DR
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 284 TRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
RLG K ++++H +F S+ W + Q+K+ PP P +AG D NF+T
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 236 bits (601), Expect = 3e-62
Identities = 123/331 (37%), Positives = 195/331 (58%), Gaps = 21/331 (6%)
Query: 44 YSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKE 103
++LQDF A +G G FG+V L + K FA+K + D++ + + EK + +
Sbjct: 652 FNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 711
Query: 104 VS---HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAI 160
V+ HPFL+ LF + + + +MEY GG+L ++ FS +FY+A ++ +
Sbjct: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGL 770
Query: 161 EYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQ 217
+YLH +IVYRDLK +N+LLD +G +K+ DFG K+ + DRT T CGTPE+LAPEV+
Sbjct: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830
Query: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
+ RAVDWW LG+LI+EML G PF D+ ++ I+ ++ +PR L ++++
Sbjct: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890
Query: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
LL + RRLG + A DVK H +FR +DW A+ +K+KPP +P I G D SNF
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF---- 946
Query: 338 ENDWDTAAPV----------PQKDLEIFKNF 358
++++ + AP+ +++ E+F++F
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDF 977
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 236 bits (601), Expect = 3e-62
Identities = 131/351 (37%), Positives = 206/351 (58%), Gaps = 13/351 (3%)
Query: 3 APGLAQAAAAESDSRKVAEETPDG-APALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
+P + ES + ++ ET + PALC SP SP +L+DF LA +G G FG
Sbjct: 579 SPSSLSSPIQESTAPELPSETQETPGPALC-SPLRKSP----LTLEDFKFLAVLGRGHFG 633
Query: 62 RVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS---HPFLIRLFWTWHD 118
+V L + + + FA+K + D++ + + + EK +L V+ HPFL+ LF +
Sbjct: 634 KVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQT 693
Query: 119 ERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 178
+ +MEY GG+L ++ + FS +FYSA ++ +++LH +IVYRDLK +N+
Sbjct: 694 PEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNL 752
Query: 179 LLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIF 235
LLD +G++K+ DFG K+ + DRT T CGTPE+LAPEV+ + RAVDWW LG+L++
Sbjct: 753 LLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLY 812
Query: 236 EMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGAN 295
EML G PF D+ ++ I+ ++ +PR L ++++LL + RRLG+ + A
Sbjct: 813 EMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAE 872
Query: 296 DVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAP 346
DVK +FR++ WEA+ R+L PP VP ++G D SNF+ + T +P
Sbjct: 873 DVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 923
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 236 bits (601), Expect = 3e-62
Identities = 131/351 (37%), Positives = 206/351 (58%), Gaps = 13/351 (3%)
Query: 3 APGLAQAAAAESDSRKVAEETPDG-APALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
+P + ES + ++ ET + PALC SP SP +L+DF LA +G G FG
Sbjct: 573 SPSSLSSPIQESTAPELPSETQETPGPALC-SPLRKSP----LTLEDFKFLAVLGRGHFG 627
Query: 62 RVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS---HPFLIRLFWTWHD 118
+V L + + + FA+K + D++ + + + EK +L V+ HPFL+ LF +
Sbjct: 628 KVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQT 687
Query: 119 ERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENI 178
+ +MEY GG+L ++ + FS +FYSA ++ +++LH +IVYRDLK +N+
Sbjct: 688 PEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNL 746
Query: 179 LLDRDGHIKLTDFGFAKKLV---DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIF 235
LLD +G++K+ DFG K+ + DRT T CGTPE+LAPEV+ + RAVDWW LG+L++
Sbjct: 747 LLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLY 806
Query: 236 EMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGAN 295
EML G PF D+ ++ I+ ++ +PR L ++++LL + RRLG+ + A
Sbjct: 807 EMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAE 866
Query: 296 DVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAP 346
DVK +FR++ WEA+ R+L PP VP ++G D SNF+ + T +P
Sbjct: 867 DVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 917
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 233 bits (595), Expect = 2e-61
Identities = 127/341 (37%), Positives = 195/341 (57%), Gaps = 14/341 (4%)
Query: 2 EAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFG 61
+A LA+ AA + EE ++ PE + P F+ L +G G +G
Sbjct: 27 DACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHC-------FELLRVLGKGGYG 79
Query: 62 RVHLVKEKTAKHF---FALKVMSIPDVIR-LKQEQHVHNEKSVLKEVSHPFLIRLFWTWH 117
+V V++ + +A+KV+ ++R K H E+++L+ V HPF++ L + +
Sbjct: 80 KVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQ 139
Query: 118 DERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPEN 177
LY+++E + GGELF++L G F T FY AEI A+ +LHS+ I+YRDLKPEN
Sbjct: 140 TGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPEN 199
Query: 178 ILLDRDGHIKLTDFGFAKKLVDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILI 234
I+L GHIKLTDFG K+ + T T CGT EY+APE++ GH RAVDWW+LG L+
Sbjct: 200 IMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALM 259
Query: 235 FEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGA 294
++ML+G PPF +N KI+ GK+ P +L +DL+KK L + ++R+G A
Sbjct: 260 YDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDA 319
Query: 295 NDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
DV+ H +FR ++W+ + ++ PP P + + D S F+T
Sbjct: 320 ADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT 360
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 231 bits (588), Expect = 1e-60
Identities = 110/293 (37%), Positives = 183/293 (62%), Gaps = 7/293 (2%)
Query: 49 FDTLATVGTGTFGRVHLVKEKT---AKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
F+ L +G G+FG+V LV++ T + H +A+KV+ ++++ E+ +L +V+
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLK-KATLKVRDRVRTKMERDILADVN 129
Query: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
HPF+++L + + E LY++++++ GG+LF+ L F+ FY AE+ +++LHS
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189
Query: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD---RTWTLCGTPEYLAPEVIQSKGHG 222
I+YRDLKPENILLD +GHIKLTDFG +K+ +D + ++ CGT EY+APEV+ +GH
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 249
Query: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVD 282
+ DWW+ G+L+FEML+G PF + IL K+ P+ L + L++ L +
Sbjct: 250 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 309
Query: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335
RLG+ +GA ++K H ++ ++DW + +R++KPP P +A DT F+T
Sbjct: 310 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 362
Score = 122 bits (307), Expect = 4e-28
Identities = 90/278 (32%), Positives = 138/278 (49%), Gaps = 29/278 (10%)
Query: 54 TVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS-HPFLIRL 112
T+G G++ K +A+KV+ K ++ E +L HP +I L
Sbjct: 432 TIGVGSYSECKRCVHKATNMEYAVKVID-------KSKRDPSEEIEILLRYGQHPNIITL 484
Query: 113 FWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRD 172
+ D + +Y++ E + GGEL + + FS F I +EYLHS+ +V+RD
Sbjct: 485 KDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD 544
Query: 173 LKPENIL-LDRDGH---IKLTDFGFAKKLVDRT---WTLCGTPEYLAPEVIQSKGHGRAV 225
LKP NIL +D G+ +++ DFGFAK+L T C T ++APEV++ +G+
Sbjct: 545 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGC 604
Query: 226 DWWALGILIFEMLSGFPPFFD---DNPFGIYQKILAGKIDFP----RHLDFHVKDLIKKL 278
D W+LGIL++ ML+G+ PF + D P I +I +GK + KDL+ K+
Sbjct: 605 DIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKM 664
Query: 279 LVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKL 316
L VD +RL A V H W D +PQ +L
Sbjct: 665 LHVDPHQRL-----TAKQVLQHPWVTQKD--KLPQSQL 695
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,581,826
Number of Sequences: 37866
Number of extensions: 769496
Number of successful extensions: 4537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 751
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2129
Number of HSP's gapped (non-prelim): 983
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.