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Search of human proteins with 13259543
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13259543 solute carrier family 25, member 14 isoform UCP5S
[Homo sapiens]
(322 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 643 0.0
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 637 0.0
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 478 e-135
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 214 1e-55
gi|13259541 uncoupling protein 2 [Homo sapiens] 199 2e-51
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 196 2e-50
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 189 2e-48
gi|11225256 uncoupling protein 1 [Homo sapiens] 172 5e-43
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 158 5e-39
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 134 1e-31
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 115 5e-26
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 107 2e-23
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 106 3e-23
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 106 3e-23
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 106 3e-23
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 106 3e-23
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 106 3e-23
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 106 3e-23
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 106 3e-23
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 106 3e-23
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 104 9e-23
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 104 9e-23
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 104 9e-23
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 101 8e-22
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 100 2e-21
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 99 4e-21
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 99 7e-21
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 99 7e-21
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 96 3e-20
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 96 3e-20
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 643 bits (1658), Expect = 0.0
Identities = 322/322 (100%), Positives = 322/322 (100%)
Query: 1 MGIFPGIILIFLRVKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDL 60
MGIFPGIILIFLRVKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDL
Sbjct: 1 MGIFPGIILIFLRVKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDL 60
Query: 61 TKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIG 120
TKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIG
Sbjct: 61 TKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIG 120
Query: 121 IYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGS 180
IYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGS
Sbjct: 121 IYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGS 180
Query: 181 FIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSF 240
FIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSF
Sbjct: 181 FIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSF 240
Query: 241 TCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNW 300
TCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNW
Sbjct: 241 TCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNW 300
Query: 301 LRLGPWNIIFFITYEQLKRLQI 322
LRLGPWNIIFFITYEQLKRLQI
Sbjct: 301 LRLGPWNIIFFITYEQLKRLQI 322
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 637 bits (1644), Expect = 0.0
Identities = 322/325 (99%), Positives = 322/325 (99%), Gaps = 3/325 (0%)
Query: 1 MGIFPGIILIFLRVKFATAAVI---HQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP 57
MGIFPGIILIFLRVKFATAAVI HQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP
Sbjct: 1 MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP 60
Query: 58 VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI 117
VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI
Sbjct: 61 VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI 120
Query: 118 KIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSM 177
KIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSM
Sbjct: 121 KIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSM 180
Query: 178 IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFV 237
IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFV
Sbjct: 181 IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFV 240
Query: 238 SSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFW 297
SSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFW
Sbjct: 241 SSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFW 300
Query: 298 PNWLRLGPWNIIFFITYEQLKRLQI 322
PNWLRLGPWNIIFFITYEQLKRLQI
Sbjct: 301 PNWLRLGPWNIIFFITYEQLKRLQI 325
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 478 bits (1231), Expect = e-135
Identities = 234/291 (80%), Positives = 262/291 (90%), Gaps = 1/291 (0%)
Query: 33 MSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRIC 92
MS LNWKPFVYGGLASI AE GTFP+DLTKTRLQ+QGQ+ DA+FKEI+YRGM HAL RI
Sbjct: 1 MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIG 60
Query: 93 KEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVIS 152
+EEG+ ALYSGIAPA+LRQASYGTIKIG YQSLKRLF+ER EDETL IN+ICG++SGVIS
Sbjct: 61 REEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVIS 120
Query: 153 STIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVEL 212
STIANPTDVLKIRMQAQ + QG MIG+F++IYQQEGTRGLW+GV TAQRAAIVVGVEL
Sbjct: 121 STIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVEL 180
Query: 213 PVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAI-VGHVD 271
PVYDITKKHLILSG+MGDT+ THF+SSFTCGLAGALASNPVDVVRTRMMNQR + G
Sbjct: 181 PVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCS 240
Query: 272 LYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI 322
Y GT+D +L+ WK+EGFFALYKGFWPNWLRLGPWNIIFF+TYEQLK+L +
Sbjct: 241 GYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKLDL 291
Score = 43.1 bits (100), Expect = 3e-04
Identities = 36/132 (27%), Positives = 52/132 (39%), Gaps = 7/132 (5%)
Query: 2 GIFPGIILIFLRVKFATAAVIHQKSTTVSHE-MSGLN----WKPFVYGGLASIVAEFGTF 56
G++ G+ L R + T H +SGL + F+ + +
Sbjct: 160 GLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASN 219
Query: 57 PVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGT 116
PVD+ +TR+ Q D R Y G L + K EG ALY G P LR +
Sbjct: 220 PVDVVRTRMMNQRVLRDGRCS--GYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNI 277
Query: 117 IKIGIYQSLKRL 128
I Y+ LK+L
Sbjct: 278 IFFVTYEQLKKL 289
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 214 bits (544), Expect = 1e-55
Identities = 118/296 (39%), Positives = 181/296 (61%), Gaps = 17/296 (5%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARF-----KEIKYRGMFHALFRICKEE 95
F+ G A+ VAE TFP+DLTKTRLQ+QG++ AR + YRGM I +EE
Sbjct: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82
Query: 96 GVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDE--TLLINMICGVVSGVISS 153
G L L+ G+ PA+ R Y ++ Y+ L+ + + EDE L ++I G+++GVI
Sbjct: 83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQ 142
Query: 154 TIANPTDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
+ANPTD++K++MQ +G F+G + +F I + G RGLW G VP QRAA
Sbjct: 143 FLANPTDLVKVQMQMEGKRKLEGKPLRFRG-VHHAFAKILAEGGIRGLWAGWVPNIQRAA 201
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQ-R 264
+V +L YD K +L+L+ + D I+TH +SS GL ++ P DV+++R+MNQ R
Sbjct: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261
Query: 265 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
G LYK + D +++ + EGF +LYKGF P+WLR+ PW+++F++TYE+++ +
Sbjct: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREM 317
Score = 77.4 bits (189), Expect = 2e-14
Identities = 46/171 (26%), Positives = 88/171 (51%), Gaps = 10/171 (5%)
Query: 38 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 97
WK + G +A ++ +F P DL K ++Q++G+ K +++RG+ HA +I E G+
Sbjct: 128 WKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKR-KLEGKPLRFRGVHHAFAKILAEGGI 186
Query: 98 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLE-DETLLINMICGVVSGVISSTIA 156
L++G P + R A + Y ++K V ++ ++ + + + SG+++S +
Sbjct: 187 RGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILG 246
Query: 157 NPTDVLKIRM-------QAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPT 200
P DV+K R+ Q +G L++ S I Q EG L++G +P+
Sbjct: 247 TPADVIKSRIMNQPRDKQGRGLLYKSS-TDCLIQAVQGEGFMSLYKGFLPS 296
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 199 bits (507), Expect = 2e-51
Identities = 107/285 (37%), Positives = 164/285 (57%), Gaps = 11/285 (3%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDA--RFKEIKYRGMFHALFRICKEEGVL 98
F+ G A+ +A+ TFP+D K RLQ+QG+S +YRG+ + + + EG
Sbjct: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
Query: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158
+LY+G+ L RQ S+ +++IG+Y S+K+ + + E ++ ++ G +G ++ +A P
Sbjct: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136
Query: 159 TDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPV 214
TDV+K+R QAQ G S + ++ I ++EG RGLW+G P R AIV EL
Sbjct: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
Query: 215 YDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYK 274
YD+ K L+ + +M D + HF S+F G + ++PVDVV+TR MN + Y
Sbjct: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-----LGQYS 251
Query: 275 GTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
L M + EG A YKGF P++LRLG WN++ F+TYEQLKR
Sbjct: 252 SAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
Score = 69.7 bits (169), Expect = 3e-12
Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 12/192 (6%)
Query: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQG----------SLFQGSMIGSFIDIYQ 186
T + + + I+ I P D K+R+Q QG S ++G+ + + +
Sbjct: 12 TATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVR 71
Query: 187 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 246
EG R L+ G+V QR V + +YD + K G +I + ++ T G
Sbjct: 72 TEGPRSLYNGLVAGLQRQMSFASVRIGLYD-SVKQFYTKGSEHASIGSRLLAGSTTGALA 130
Query: 247 ALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPW 306
+ P DVV+ R Q A G Y+ TV+ + + EGF L+KG PN R
Sbjct: 131 VAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
Query: 307 NIIFFITYEQLK 318
N +TY+ +K
Sbjct: 190 NCAELVTYDLIK 201
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 196 bits (499), Expect = 2e-50
Identities = 108/289 (37%), Positives = 170/289 (58%), Gaps = 16/289 (5%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-IKYRGMFHALFRICKEEGVLA 99
F+ G A+ A+ TFP+D K RLQ+QG++ + ++YRG+ + + + EG +
Sbjct: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
Query: 100 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVER-LEDETLLINMICGVVSGVISSTIANP 158
Y+G+ L RQ S+ +I+IG+Y S+K+++ + ++ +L ++ G +G ++ T A P
Sbjct: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
Query: 159 TDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGV 210
TDV+K+R QA L + G+M ++ I ++EG RGLW+G +P R AIV
Sbjct: 137 TDVVKVRFQASIHLGPSRSDRKYSGTM-DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
Query: 211 ELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHV 270
E+ YDI K+ L+ ++ D HFVS+F G + ++PVDVV+TR MN
Sbjct: 196 EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPP----- 250
Query: 271 DLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
Y +D ++KM EG A YKGF P++LRLG WN++ F+TYEQLKR
Sbjct: 251 GQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299
Score = 63.2 bits (152), Expect = 3e-10
Identities = 47/197 (23%), Positives = 83/197 (42%), Gaps = 19/197 (9%)
Query: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGS---------LFQGSMIGSFIDIYQQ 187
T+ + + + + + P D K+R+Q QG + ++G+ + + +
Sbjct: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71
Query: 188 EGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGA 247
EG + G+V QR + + +YD K+ G ++ T ++ T G
Sbjct: 72 EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAV 131
Query: 248 LASNPVDVVRTRMMNQRAIVGHVD------LYKGTVDGILKMWKHEGFFALYKGFWPNWL 301
+ P DVV+ R Q +I H+ Y GT+D + + EG L+KG PN +
Sbjct: 132 TCAQPTDVVKVRF--QASI--HLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIM 187
Query: 302 RLGPWNIIFFITYEQLK 318
R N +TY+ LK
Sbjct: 188 RNAIVNCAEVVTYDILK 204
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 12/91 (13%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F G A++VA PVD+ KTR +Y + ++ +EG A
Sbjct: 225 FGAGFCATVVAS----PVDVVKTRYMNSPPG--------QYFSPLDCMIKMVAQEGPTAF 272
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVE 131
Y G P+ LR S+ + Y+ LKR ++
Sbjct: 273 YKGFTPSFLRLGSWNVVMFVTYEQLKRALMK 303
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 189 bits (481), Expect = 2e-48
Identities = 114/309 (36%), Positives = 168/309 (54%), Gaps = 20/309 (6%)
Query: 26 STTVSHEMSGLNWKP--------FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFK 77
+ T S G++ KP F++GGLA + A P+DL K R+Q+ G+ R
Sbjct: 2 AATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR-- 59
Query: 78 EIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSL-KRLFVERLEDE 136
+Y+ FHAL I K EG+ +Y+G++ LLRQA+Y T ++GIY L +RL
Sbjct: 60 --EYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPP 117
Query: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIG------SFIDIYQQEGT 190
L+ + G+ +G + + P +V IRM A G L G + I I ++EG
Sbjct: 118 GFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGV 177
Query: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250
LWRG +PT RA +V +L Y +K+ L+ SG D IL HF +S GL AS
Sbjct: 178 LTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAAS 237
Query: 251 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 310
PVD+ +TR+ N R I G + YK +D + K+ ++EGFF+L+KGF P + RLGP ++
Sbjct: 238 MPVDIAKTRIQNMRMIDGKPE-YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLT 296
Query: 311 FITYEQLKR 319
FI EQ+ +
Sbjct: 297 FIFLEQMNK 305
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 172 bits (435), Expect = 5e-43
Identities = 97/282 (34%), Positives = 157/282 (55%), Gaps = 15/282 (5%)
Query: 45 GLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGI 104
G+A+ +A+ TFP+D K RLQVQG+ + I+Y+G+ + + K EG + LYSG+
Sbjct: 21 GIAACLADVITFPLDTAKVRLQVQGECPTSSV--IRYKGVLGTITAVVKTEGRMKLYSGL 78
Query: 105 APALLRQASYGTIKIGIYQSLKRLFVERLEDETLL-INMICGVVSGVISSTIANPTDVLK 163
L RQ S +++IG+Y +++ E L ++ G+ +G ++ I PT+V+K
Sbjct: 79 PAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVK 138
Query: 164 IRMQAQGSL------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
+R+QAQ L + G+ ++ I EG GLW+G P R+ I+ EL YD+
Sbjct: 139 VRLQAQSHLHGIKPRYTGTY-NAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDL 197
Query: 218 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTV 277
K+ + + ++ D + H VS+ G S+PVDVV+TR +N YK
Sbjct: 198 MKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPP-----GQYKSVP 252
Query: 278 DGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
+ +K++ +EG A +KG P++LRLG WN+I F+ +EQLKR
Sbjct: 253 NCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 6/188 (3%)
Query: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMI------GSFIDIYQQEGT 190
TL + + ++ ++ I P D K+R+Q QG S+I G+ + + EG
Sbjct: 12 TLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGR 71
Query: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250
L+ G+ QR + + +YD ++ L ++ + ++ T G
Sbjct: 72 MKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIG 131
Query: 251 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 310
P +VV+ R+ Q + G Y GT + + EG L+KG PN +R N
Sbjct: 132 QPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTE 191
Query: 311 FITYEQLK 318
+TY+ +K
Sbjct: 192 LVTYDLMK 199
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 158 bits (400), Expect = 5e-39
Identities = 92/265 (34%), Positives = 149/265 (56%), Gaps = 16/265 (6%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-IKYRGMFHALFRICKEEGVLA 99
F+ G A+ A+ TFP+D K RLQ+QG++ + ++YRG+ + + + EG +
Sbjct: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
Query: 100 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVER-LEDETLLINMICGVVSGVISSTIANP 158
Y+G+ L RQ S+ +I+IG+Y S+K+++ + ++ +L ++ G +G ++ T A P
Sbjct: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
Query: 159 TDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGV 210
TDV+K+R QA L + G+M ++ I ++EG RGLW+G +P R AIV
Sbjct: 137 TDVVKVRFQASIHLGPSRSDRKYSGTM-DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
Query: 211 ELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHV 270
E+ YDI K+ L+ ++ D HFVS+F G + ++PVDVV+TR MN
Sbjct: 196 EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPP----- 250
Query: 271 DLYKGTVDGILKMWKHEGFFALYKG 295
Y +D ++KM EG A YKG
Sbjct: 251 GQYFSPLDCMIKMVAQEGPTAFYKG 275
Score = 63.2 bits (152), Expect = 3e-10
Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 21/198 (10%)
Query: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGS----------LFQGSMIGSFIDIYQ 186
T+ + + + + + P D K+R+Q QG ++G ++G+ + + +
Sbjct: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG-VLGTILTMVR 70
Query: 187 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 246
EG + G+V QR + + +YD K+ G ++ T ++ T G
Sbjct: 71 TEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMA 130
Query: 247 ALASNPVDVVRTRMMNQRAIVGHVD------LYKGTVDGILKMWKHEGFFALYKGFWPNW 300
+ P DVV+ R Q +I H+ Y GT+D + + EG L+KG PN
Sbjct: 131 VTCAQPTDVVKVRF--QASI--HLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
Query: 301 LRLGPWNIIFFITYEQLK 318
+R N +TY+ LK
Sbjct: 187 MRNAIVNCAEVVTYDILK 204
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 134 bits (337), Expect = 1e-31
Identities = 90/284 (31%), Positives = 144/284 (50%), Gaps = 23/284 (8%)
Query: 43 YGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYS 102
+GGLAS A T P+DL K LQ Q +E+K R AL R+ + +G+LALYS
Sbjct: 12 FGGLASCGAACCTHPLDLLKVHLQTQ--------QEVKLRMTGMAL-RVVRTDGILALYS 62
Query: 103 GIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN-MICGVVSGVISSTIANPTDV 161
G++ +L RQ +Y + IY++++ + + ++ G VSG+ + P D+
Sbjct: 63 GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122
Query: 162 LKIRMQAQGSLFQGSM------IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVY 215
+ +RMQ L QG + + ++EG R L+ G + R A+V +L Y
Sbjct: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
Query: 216 DITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKG 275
D K+ ++ +G + D I THFV+SF G P+DV++TR+MN + Y+G
Sbjct: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKG------EYQG 236
Query: 276 TVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
++ K G A YKG P +RL P ++ F+ EQL++
Sbjct: 237 VFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
Score = 36.2 bits (82), Expect = 0.040
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F+ GG A+ + + P+D+ KTRL + +Y+G+FH K G LA
Sbjct: 207 FIAGGCATFLCQ----PLDVLKTRLMNS---------KGEYQGVFHCAVETAKL-GPLAF 252
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLF 129
Y G+ PA +R + + + L++ F
Sbjct: 253 YKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 115 bits (288), Expect = 5e-26
Identities = 79/289 (27%), Positives = 139/289 (48%), Gaps = 14/289 (4%)
Query: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101
V G A +A T P+++ KTRLQ+QG+ Y G ++ + + +G+ L
Sbjct: 11 VLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQ 70
Query: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDV 161
G+A LL Q ++ Y + + + T+ + G V+G + + + +P +
Sbjct: 71 KGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTV----VAGAVAGALGAFVGSPAYL 126
Query: 162 LKIRMQAQ--GSLFQG------SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 213
+K ++QAQ ++ G +++G+ I++Q+G GLW+GV R + +L
Sbjct: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
Query: 214 VYDITKKHLILSGMMG-DTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRA-IVGHVD 271
+ K + + D+ L +A + P DVV TR+ NQ G
Sbjct: 187 TFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQ 246
Query: 272 LYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
LY G D ++K+W+ EG ALYKG P +LRLGP I+ + +++L++L
Sbjct: 247 LYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKL 295
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/168 (22%), Positives = 75/168 (44%), Gaps = 18/168 (10%)
Query: 140 INMICGVVSGVISSTIANPTDVLKIRMQAQGSL---------FQGSMIGSFIDIYQQEGT 190
++++ G + ++ NP +V+K R+Q QG L + G I S + + +G
Sbjct: 8 VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHG-FIASVAAVARADGL 66
Query: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250
GL +G+ ++ GV Y + + L+ G T+ V+ G GA
Sbjct: 67 WGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-AGLTQQPGGTV----VAGAVAGALGAFVG 121
Query: 251 NPVDVVRTRMMNQ---RAIVGHVDLYKGTVDGILKMWKHEGFFALYKG 295
+P +++T++ Q VGH ++ + + +W+ +G L++G
Sbjct: 122 SPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQG 169
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 107 bits (266), Expect = 2e-23
Identities = 79/284 (27%), Positives = 131/284 (46%), Gaps = 12/284 (4%)
Query: 38 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 97
WK + G +A V+ GT P+D K +QV + + + L + +E G
Sbjct: 93 WKFLLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTN-------FTNLLGGLQSMVQEGGF 145
Query: 98 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIAN 157
+L+ G +L+ A IK +++ K F ++ G ++ IS T+ N
Sbjct: 146 RSLWRGNGINVLKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQERLLAGSLAVAISQTLIN 205
Query: 158 PTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
P +VLK R+ + + ++ I Q+EGTR L+RG +P +L VY++
Sbjct: 206 PMEVLKTRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEM 265
Query: 218 TKKHLILSGM-MGDTILTHFVSSFTCG-LAGALASNPVDVVRTRMMNQRAIVGHVDLYKG 275
+ + SG MGD +SS T G +AS P+ +VRTRM Q + G +G
Sbjct: 266 LQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTMRG 325
Query: 276 TVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
+ IL +G+ LY+G P L++ P I ++ YE +K+
Sbjct: 326 VLQRIL---AQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKK 366
Score = 68.9 bits (167), Expect = 6e-12
Identities = 51/185 (27%), Positives = 90/185 (48%), Gaps = 15/185 (8%)
Query: 44 GGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSG 103
G LA +++ P+++ KTRL ++ +Y+G+ +I + EG ALY G
Sbjct: 193 GSLAVAISQTLINPMEVLKTRLTLRRTG--------QYKGLLDCARQILQREGTRALYRG 244
Query: 104 IAPALLRQASYGTIKIGIYQSLKRLFVER---LEDETLLINMICGVVSGVISSTIANPTD 160
P +L Y + +Y+ L+ +V+ + D + L+++ +S + P
Sbjct: 245 YLPNMLGIIPYACTDLAVYEMLQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQMASYPLT 304
Query: 161 VLKIRMQAQGSLFQGS---MIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
+++ RMQAQ ++ +GS M G I Q+G GL+RG+ PT + G+ VY+
Sbjct: 305 LVRTRMQAQDTV-EGSNPTMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEA 363
Query: 218 TKKHL 222
KK L
Sbjct: 364 MKKTL 368
Score = 65.5 bits (158), Expect = 6e-11
Identities = 53/191 (27%), Positives = 88/191 (46%), Gaps = 21/191 (10%)
Query: 136 ETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQ-GSMIGSFIDIYQQEGTRGLW 194
E L ++ G ++G +S T P D K+ MQ S +++G + Q+ G R LW
Sbjct: 90 EALWKFLLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLW 149
Query: 195 RGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS---- 250
RG + A ++ V++ K + G+ G + LAG+LA
Sbjct: 150 RGNGINVLKIAPEYAIKFSVFEQCKNYFC--GIQGSPPFQERL------LAGSLAVAISQ 201
Query: 251 ---NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWN 307
NP++V++TR+ +R YKG +D ++ + EG ALY+G+ PN L + P+
Sbjct: 202 TLINPMEVLKTRLTLRRT-----GQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYA 256
Query: 308 IIFFITYEQLK 318
YE L+
Sbjct: 257 CTDLAVYEMLQ 267
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 177 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 232
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 233 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 287
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 288 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 347
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 348 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 406
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 407 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 244
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRL 270
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 211 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 266
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 267 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 321
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 322 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 381
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 382 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 440
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 441 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 278
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRL 304
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 106 bits (264), Expect = 3e-23
Identities = 85/296 (28%), Positives = 135/296 (45%), Gaps = 22/296 (7%)
Query: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
K F+ GG+A+ +++ P++ K LQVQ S + +Y+G+ + RI KE+GVL
Sbjct: 10 KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK-QYKGIVDCIVRIPKEQGVL 68
Query: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI-----NMICGVVSGVISS 153
+ + G ++R + K++F+ ++ T N+ G +G S
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
Query: 154 TIANPTDVLKIRMQAQ----GSLFQGSMIGS-FIDIYQQEGTRGLWRGVVPTAQRAAIVV 208
P D + R+ A G+ + +G + I + +G RGL++G + Q I
Sbjct: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
Query: 209 GVELPVYDITKKHLILSGMMGDTILTHFVSSF----TCGLAGALASNPVDVVRTRMMNQR 264
VYD K GM+ D TH V S+ T + S P D VR RMM Q
Sbjct: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242
Query: 265 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
G +Y GTVD K+++ EG A +KG W N LR G + Y++LK++
Sbjct: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKV 297
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 197 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 252
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 253 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 307
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 308 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 367
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 368 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 426
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 427 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 481
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 264
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 265 GNGINVLKIAPESAIKFMAYEQIKRL 290
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 177 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 232
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 233 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 287
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 288 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 347
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 348 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 406
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 407 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 244
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 245 GNGINVLKIAPESAIKFMAYEQIKRL 270
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 74 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 129
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 130 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 184
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 185 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 244
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 245 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 303
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 304 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 358
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 141
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 142 GNGINVLKIAPESAIKFMAYEQIKRL 167
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 106 bits (264), Expect = 3e-23
Identities = 80/293 (27%), Positives = 139/293 (47%), Gaps = 16/293 (5%)
Query: 32 EMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRI 91
+++G+ WK V G +A V+ GT P+D K +QV + + L +
Sbjct: 180 KLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRL-------NILGGLRSM 232
Query: 92 CKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVI 151
E G+ +L+ G +L+ A IK Y+ +KR + + E + + G ++G
Sbjct: 233 VLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGAT 292
Query: 152 SSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVE 211
+ TI P +VLK R+ + + ++ I ++EG R +RG +P G++
Sbjct: 293 AQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGID 352
Query: 212 LPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMMNQRAIV 267
L VY+ T K+ L D+ + CG G +AS P+ +VRTRM Q +I
Sbjct: 353 LAVYE-TLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIE 411
Query: 268 GHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
G L ++ G+L+ + EG LY+G PN++++ P I ++ YE +K+
Sbjct: 412 GGPQL---SMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQ 461
Score = 94.7 bits (234), Expect = 1e-19
Identities = 65/227 (28%), Positives = 107/227 (47%), Gaps = 22/227 (9%)
Query: 3 IFPGIILIFLRVKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTK 62
I P + F+ + A++ Q+ T E FV G LA A+ +P+++ K
Sbjct: 252 IAPESAIKFMAYEQIKRAILGQQETLHVQER-------FVAGSLAGATAQTIIYPMEVLK 304
Query: 63 TRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIY 122
TRL ++ +Y+G+ RI + EG A Y G P +L Y I + +Y
Sbjct: 305 TRLTLRRTG--------QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVY 356
Query: 123 QSLKRLFVERLE----DETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG--- 175
++LK ++++ D +L+ + CG +S + P +++ RMQAQ S+ G
Sbjct: 357 ETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQL 416
Query: 176 SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHL 222
SM+G I QEG RGL+RG+ P + V + VY+ K+ L
Sbjct: 417 SMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 106 bits (264), Expect = 3e-23
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 20/298 (6%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
TV +G+ W+ V GG A V+ T P+D K +QV +R + G F
Sbjct: 211 TVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHA----SRSNNMGIVGGFTQ 266
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN--MICG 145
+ R E G +L+ G +L+ A IK Y+ +KRL + ETL I+ ++ G
Sbjct: 267 MIR---EGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGS--DQETLRIHERLVAG 321
Query: 146 VVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
++G I+ + P +VLK RM + + M+ I +EG ++G VP
Sbjct: 322 SLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGII 381
Query: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMM 261
G++L VY+ K + + FV CG G LAS P+ +VRTRM
Sbjct: 382 PYAGIDLAVYETLKNAWLQHYAVNSADPGVFV-LLACGTMSSTCGQLASYPLALVRTRMQ 440
Query: 262 NQRAIVGHVDLYKGTVDGILK-MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLK 318
Q +I G ++ T+ + K + + EG F LY+G PN++++ P I ++ YE LK
Sbjct: 441 AQASIEGAPEV---TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 235 HFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYK 294
H V+ G + P+D ++ M + ++ G V G +M + G +L++
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM----GIVGGFTQMIREGGARSLWR 278
Query: 295 GFWPNWLRLGPWNIIFFITYEQLKRL 320
G N L++ P + I F+ YEQ+KRL
Sbjct: 279 GNGINVLKIAPESAIKFMAYEQIKRL 304
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 104 bits (260), Expect = 9e-23
Identities = 83/295 (28%), Positives = 134/295 (45%), Gaps = 22/295 (7%)
Query: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
K F+ GG+A+ +++ P++ K LQVQ S + +Y+G+ + RI KE+GVL
Sbjct: 10 KDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADK-QYKGIIDCVVRIPKEQGVL 68
Query: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI-----NMICGVVSGVISS 153
+ + G ++R + K++F+ ++ T N+ G +G S
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSL 128
Query: 154 TIANPTDVLKIRMQAQ----GSLFQGSMIGS-FIDIYQQEGTRGLWRGVVPTAQRAAIVV 208
P D + R+ A G+ + +G + IY+ +G +GL++G + Q I
Sbjct: 129 CFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYR 188
Query: 209 GVELPVYDITKKHLILSGMMGDTILTHFVSSF----TCGLAGALASNPVDVVRTRMMNQR 264
+YD K GM+ D TH V S+ T L S P D VR RMM Q
Sbjct: 189 AAYFGIYDTAK------GMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQS 242
Query: 265 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
G +Y GT+D K+ + EG A +KG W N LR G + Y+++K+
Sbjct: 243 GRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 104 bits (260), Expect = 9e-23
Identities = 77/296 (26%), Positives = 130/296 (43%), Gaps = 14/296 (4%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
T + SG W+ + GG+A V+ T P+D K +QV G D +F
Sbjct: 185 TEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM-------NIFGG 237
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVV 147
++ KE G+ +L+ G +++ A +K Y+ K+L E + I G +
Sbjct: 238 FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM 297
Query: 148 SGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIV 207
+G + T P +V+K R+ + + I + EG ++G VP
Sbjct: 298 AGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 357
Query: 208 VGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMMNQ 263
G++L VY++ K + L D++ + CG G LAS P+ +VRTRM Q
Sbjct: 358 AGIDLAVYELLKSYW-LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ 416
Query: 264 RAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
+ G L V ++ EG LY+G PN++++ P I ++ YE +K+
Sbjct: 417 AMLEGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 470
Score = 88.6 bits (218), Expect = 7e-18
Identities = 56/189 (29%), Positives = 94/189 (49%), Gaps = 15/189 (7%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F+ G +A A+ +P+++ KTRL V K +Y G++ +I K EG+ A
Sbjct: 292 FISGSMAGATAQTFIYPMEVMKTRLAVG--------KTGQYSGIYDCAKKILKHEGLGAF 343
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET----LLINMICGVVSGVISSTIA 156
Y G P LL Y I + +Y+ LK +++ ++ +++ + CG +S +
Sbjct: 344 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 403
Query: 157 NPTDVLKIRMQAQGSLF---QGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 213
P +++ RMQAQ L Q +M+G F I +EG GL+RG+ P + VG+
Sbjct: 404 YPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYV 463
Query: 214 VYDITKKHL 222
VY+ K+ L
Sbjct: 464 VYENMKQTL 472
Score = 31.6 bits (70), Expect = 0.99
Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 7/81 (8%)
Query: 243 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 299
G+AGA++ P+D ++ M + ++++ G +M K G +L++G N
Sbjct: 202 GIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIF----GGFRQMVKEGGIRSLWRGNGTN 257
Query: 300 WLRLGPWNIIFFITYEQLKRL 320
+++ P + F YEQ K+L
Sbjct: 258 VIKIAPETAVKFWAYEQYKKL 278
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 104 bits (260), Expect = 9e-23
Identities = 77/296 (26%), Positives = 130/296 (43%), Gaps = 14/296 (4%)
Query: 28 TVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHA 87
T + SG W+ + GG+A V+ T P+D K +QV G D +F
Sbjct: 166 TEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKM-------NIFGG 218
Query: 88 LFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVV 147
++ KE G+ +L+ G +++ A +K Y+ K+L E + I G +
Sbjct: 219 FRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSM 278
Query: 148 SGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIV 207
+G + T P +V+K R+ + + I + EG ++G VP
Sbjct: 279 AGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 338
Query: 208 VGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCG----LAGALASNPVDVVRTRMMNQ 263
G++L VY++ K + L D++ + CG G LAS P+ +VRTRM Q
Sbjct: 339 AGIDLAVYELLKSYW-LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQ 397
Query: 264 RAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
+ G L V ++ EG LY+G PN++++ P I ++ YE +K+
Sbjct: 398 AMLEGSPQL--NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
Score = 88.6 bits (218), Expect = 7e-18
Identities = 56/189 (29%), Positives = 94/189 (49%), Gaps = 15/189 (7%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F+ G +A A+ +P+++ KTRL V K +Y G++ +I K EG+ A
Sbjct: 273 FISGSMAGATAQTFIYPMEVMKTRLAVG--------KTGQYSGIYDCAKKILKHEGLGAF 324
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET----LLINMICGVVSGVISSTIA 156
Y G P LL Y I + +Y+ LK +++ ++ +++ + CG +S +
Sbjct: 325 YKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLAS 384
Query: 157 NPTDVLKIRMQAQGSLF---QGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 213
P +++ RMQAQ L Q +M+G F I +EG GL+RG+ P + VG+
Sbjct: 385 YPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYV 444
Query: 214 VYDITKKHL 222
VY+ K+ L
Sbjct: 445 VYENMKQTL 453
Score = 31.6 bits (70), Expect = 0.99
Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 7/81 (8%)
Query: 243 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 299
G+AGA++ P+D ++ M + ++++ G +M K G +L++G N
Sbjct: 183 GIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIF----GGFRQMVKEGGIRSLWRGNGTN 238
Query: 300 WLRLGPWNIIFFITYEQLKRL 320
+++ P + F YEQ K+L
Sbjct: 239 VIKIAPETAVKFWAYEQYKKL 259
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 101 bits (252), Expect = 8e-22
Identities = 78/280 (27%), Positives = 124/280 (44%), Gaps = 7/280 (2%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F G +A V +P+DL KTR+Q Q S + E+ Y+ F ++ + EG L
Sbjct: 330 FTLGSVAGAVGATAVYPIDLVKTRMQNQRGS-GSVVGELMYKNSFDCFKKVLRYEGFFGL 388
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTD 160
Y G+ P L+ A IK+ + ++ F R L ++ G +G NP +
Sbjct: 389 YRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLE 448
Query: 161 VLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKK 220
++KIR+Q G + G + S +++ + G GL++G R + PVY K
Sbjct: 449 IVKIRLQVAGEITTGPRV-SALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCK- 506
Query: 221 HLILSGMMGDT-ILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDG 279
L+L+ G L + G+ A P DV++TR+ Q A Y G +D
Sbjct: 507 -LLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRL--QVAARAGQTTYSGVIDC 563
Query: 280 ILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
K+ + EG A +KG R P + +TYE L+R
Sbjct: 564 FRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603
Score = 59.3 bits (142), Expect = 4e-09
Identities = 51/184 (27%), Positives = 82/184 (44%), Gaps = 16/184 (8%)
Query: 145 GVVSGVISSTIANPTDVLKIRMQAQ-------GSLFQGSMIGSFIDIYQQEGTRGLWRGV 197
G V+G + +T P D++K RMQ Q G L + F + + EG GL+RG+
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 198 VPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTC-GLAGALASNPVDVV 256
+P A ++L V D + G L V + C G + + +NP+++V
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRD--GSVPLPAEVLAGGCAGGSQVIFTNPLEIV 450
Query: 257 RTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQ 316
+ R+ + G + G L + + G F LYKG +LR P++ I+F Y
Sbjct: 451 KIRLQ----VAGEITT--GPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAH 504
Query: 317 LKRL 320
K L
Sbjct: 505 CKLL 508
Score = 43.1 bits (100), Expect = 3e-04
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 2 GIFPGIILIFLR------VKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGT 55
G++ G FLR + F A + + GLN G +A + A
Sbjct: 479 GLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNL--LAAGAMAGVPAASLV 536
Query: 56 FPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYG 115
P D+ KTRLQV AR + Y G+ +I +EEG A + G A + R +
Sbjct: 537 TPADVIKTRLQVA-----ARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQF 591
Query: 116 TIKIGIYQSLKRLF 129
+ + Y+ L+R F
Sbjct: 592 GVTLVTYELLQRWF 605
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 135/285 (47%), Gaps = 18/285 (6%)
Query: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
+ V GG A +V P+D+ KTR Q+Q + D Y+ + + I + EG+
Sbjct: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPN----SYKSLVDSFRMIFQMEGLF 70
Query: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158
Y GI P +L + +K ++ K+L + + L I G+ SG+ + + NP
Sbjct: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPALTFAIAGLGSGLTEAIVVNP 129
Query: 159 TDVLKIRMQAQGSLF--QGSMIGSFIDIYQQEG--TRGLWRGVVPTAQRAAIVVGVELPV 214
+V+K+ +QA + F Q S +G I ++EG +GL +G+ T R + V
Sbjct: 130 FEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGF 189
Query: 215 YDITKKHLILSGMMGDTILTHFVSSFTCGL-AGALASN---PVDVVRTRMMNQRAIVGHV 270
Y K + ++ D IL F F GL +G +AS P DV ++R+ + + G +
Sbjct: 190 YYNVKNMIPVNK---DPIL-EFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEI 245
Query: 271 DLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
Y+ + +++ EG ALYKG P +RLGP + + YE
Sbjct: 246 K-YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 55.8 bits (133), Expect = 5e-08
Identities = 46/183 (25%), Positives = 80/183 (43%), Gaps = 7/183 (3%)
Query: 142 MICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGV 197
++ G +G++ + +P DV+K R Q Q S++ SF I+Q EG G ++G+
Sbjct: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
Query: 198 VPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVR 257
+P V+ ++ KK +L + LT ++ GL A+ NP +VV+
Sbjct: 77 LPPILAETPKRAVKFFTFEQYKK--LLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVK 134
Query: 258 TRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 317
+ R G I+K + G L KG R G +N+++F Y +
Sbjct: 135 VGLQANRNTFAEQPSTVGYARQIIKK-EGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNV 193
Query: 318 KRL 320
K +
Sbjct: 194 KNM 196
Score = 54.7 bits (130), Expect = 1e-07
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
Query: 38 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 97
W+ F G L+ +A P D+ K+R+Q Q + EIKYR F + + +EEG+
Sbjct: 208 WRKFGIGLLSGTIASVINIPFDVAKSRIQGP-QPVPG---EIKYRTCFKTMATVYQEEGI 263
Query: 98 LALYSGIAPALLRQASYGTIKIGIYQ 123
LALY G+ P ++R G + + +Y+
Sbjct: 264 LALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 16/187 (8%)
Query: 41 FVYGGLASIVAE-FGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEG--V 97
F GL S + E P ++ K LQ + + + Y +I K+EG +
Sbjct: 112 FAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR------QIIKKEGWGL 165
Query: 98 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI--NMICGVVSGVISSTI 155
L G+ L R + + G Y ++K + +D L G++SG I+S I
Sbjct: 166 QGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVN-KDPILEFWRKFGIGLLSGTIASVI 224
Query: 156 ANPTDVLKIRMQAQ----GSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVE 211
P DV K R+Q G + + + +YQ+EG L++G++P R V
Sbjct: 225 NIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
Query: 212 LPVYDIT 218
L VY+ T
Sbjct: 285 LLVYEYT 291
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 99.4 bits (246), Expect = 4e-21
Identities = 85/297 (28%), Positives = 130/297 (43%), Gaps = 26/297 (8%)
Query: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
K F+ GG+A+ V++ P++ K LQVQ S E +Y+G+ + RI KE+G L
Sbjct: 10 KDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQIS-AEKQYKGIIDCVVRIPKEQGFL 68
Query: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI-----NMICGVVSGVISS 153
+ + G ++R + K+LF+ ++ N+ G +G S
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSL 128
Query: 154 TIANPTDVLKIRMQAQGSLFQGSMIGSF-------IDIYQQEGTRGLWRGVVPTAQRAAI 206
P D + R+ A + +G+ F I I++ +G RGL++G + Q I
Sbjct: 129 CFVYPLDFARTRLAAD--VGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIII 186
Query: 207 VVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLA----GALASNPVDVVRTRMMN 262
VYD K GM+ D H S+ + L S P D VR RMM
Sbjct: 187 YRAAYFGVYDTAK------GMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMM 240
Query: 263 QRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
Q G +Y GTVD K+ K EG A +KG W N LR G + Y+++K+
Sbjct: 241 QSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296
Score = 35.8 bits (81), Expect = 0.053
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 228 MGDTILTHFVSSFTCGLAGALASN---PVDVVRTRMMNQRAI--VGHVDLYKGTVDGILK 282
MGD + G+A A++ P++ V+ + Q A + YKG +D +++
Sbjct: 1 MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR 60
Query: 283 MWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
+ K +GF + ++G N +R P + F ++ K+L
Sbjct: 61 IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQL 98
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 98.6 bits (244), Expect = 7e-21
Identities = 75/280 (26%), Positives = 123/280 (43%), Gaps = 7/280 (2%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F G +A V +P+DL KTR+Q Q +S + E+ Y+ F ++ + EG L
Sbjct: 332 FGLGSVAGAVGATAVYPIDLVKTRMQNQ-RSTGSFVGELMYKNSFDCFKKVLRYEGFFGL 390
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTD 160
Y G+ P LL A IK+ + ++ F+ + L ++ G +G NP +
Sbjct: 391 YRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLE 450
Query: 161 VLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKK 220
++KIR+Q G + G + S + + + G G+++G R + P Y K
Sbjct: 451 IVKIRLQVAGEITTGPRV-SALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 509
Query: 221 HLI-LSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDG 279
G + L ++ G+ A P DV++TR+ Q A Y G +D
Sbjct: 510 SFANEDGQVSPGSL--LLAGAIAGMPAASLVTPADVIKTRL--QVAARAGQTTYSGVIDC 565
Query: 280 ILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
K+ + EG AL+KG R P + +TYE L+R
Sbjct: 566 FRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605
Score = 43.5 bits (101), Expect = 3e-04
Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 9/132 (6%)
Query: 2 GIFPGIILIFLR-VKFATA---AVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP 57
GI+ G FLR + F+ H K++ + + + G +A + A P
Sbjct: 481 GIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTP 540
Query: 58 VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI 117
D+ KTRLQV AR + Y G+ +I +EEG AL+ G + R + +
Sbjct: 541 ADVIKTRLQVA-----ARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGV 595
Query: 118 KIGIYQSLKRLF 129
+ Y+ L+R F
Sbjct: 596 TLLTYELLQRWF 607
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 98.6 bits (244), Expect = 7e-21
Identities = 75/280 (26%), Positives = 123/280 (43%), Gaps = 7/280 (2%)
Query: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
F G +A V +P+DL KTR+Q Q +S + E+ Y+ F ++ + EG L
Sbjct: 333 FGLGSVAGAVGATAVYPIDLVKTRMQNQ-RSTGSFVGELMYKNSFDCFKKVLRYEGFFGL 391
Query: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTD 160
Y G+ P LL A IK+ + ++ F+ + L ++ G +G NP +
Sbjct: 392 YRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLE 451
Query: 161 VLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKK 220
++KIR+Q G + G + S + + + G G+++G R + P Y K
Sbjct: 452 IVKIRLQVAGEITTGPRV-SALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 510
Query: 221 HLI-LSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDG 279
G + L ++ G+ A P DV++TR+ Q A Y G +D
Sbjct: 511 SFANEDGQVSPGSL--LLAGAIAGMPAASLVTPADVIKTRL--QVAARAGQTTYSGVIDC 566
Query: 280 ILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
K+ + EG AL+KG R P + +TYE L+R
Sbjct: 567 FRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606
Score = 43.5 bits (101), Expect = 3e-04
Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 9/132 (6%)
Query: 2 GIFPGIILIFLR-VKFATA---AVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP 57
GI+ G FLR + F+ H K++ + + + G +A + A P
Sbjct: 482 GIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTP 541
Query: 58 VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI 117
D+ KTRLQV AR + Y G+ +I +EEG AL+ G + R + +
Sbjct: 542 ADVIKTRLQVA-----ARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGV 596
Query: 118 KIGIYQSLKRLF 129
+ Y+ L+R F
Sbjct: 597 TLLTYELLQRWF 608
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/287 (24%), Positives = 128/287 (44%), Gaps = 15/287 (5%)
Query: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101
V G ++ +V P D+ K R Q+Q + + KY G+ A +I +EEG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVER---LEDETLLINMICGVVSGVISSTIANP 158
G PA + YG ++ ++ L L V R + ++ +CG ++ +++ +P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL-VHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
Query: 159 TDVLKIRMQAQGS-LFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
DVL+ R AQG ++ + +Y+ EG + ++G+ PT G++ Y
Sbjct: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS- 197
Query: 218 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASN----PVDVVRTRMM-----NQRAIVG 268
+ KHL + + + + CG + S P+D+ + R+ + RA G
Sbjct: 198 SLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
Query: 269 HVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
V YKG +D ++ + EG +KG P+ L+ F +YE
Sbjct: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 84.7 bits (208), Expect = 1e-16
Identities = 61/204 (29%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 21 VIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIK 80
++H+ S + E S FV GGLA+ +A PVD+ +TR QG+
Sbjct: 106 LVHRGSVYDAREFS----VHFVCGGLAACMATLTVHPVDVLRTRFAAQGE-------PKV 154
Query: 81 YRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLF-----VERLED 135
Y + HA+ + + EG Y G+AP L+ Y ++ Y SLK L+ E ++
Sbjct: 155 YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN 214
Query: 136 ETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSF----------IDIY 185
E L N++CG +GVIS T+ P D+ K R+Q G + G +
Sbjct: 215 ENLQ-NLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVL 273
Query: 186 QQEGTRGLWRGVVPTAQRAAIVVG 209
Q+EG G ++G+ P+ +AA+ G
Sbjct: 274 QKEGALGFFKGLSPSLLKAALSTG 297
Score = 29.6 bits (65), Expect = 3.8
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 237 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVD---LYKGTVDGILKMWKHEGFFALY 293
V+ GL +P DV++ R Q + D Y G + ++ + EG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 294 KGFWPNWLRLGPWNIIFFITYEQLKRL 320
KG P + + + F+++E L L
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL 106
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/287 (24%), Positives = 128/287 (44%), Gaps = 15/287 (5%)
Query: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101
V G ++ +V P D+ K R Q+Q + + KY G+ A +I +EEG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVER---LEDETLLINMICGVVSGVISSTIANP 158
G PA + YG ++ ++ L L V R + ++ +CG ++ +++ +P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL-VHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
Query: 159 TDVLKIRMQAQGS-LFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
DVL+ R AQG ++ + +Y+ EG + ++G+ PT G++ Y
Sbjct: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS- 197
Query: 218 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASN----PVDVVRTRMM-----NQRAIVG 268
+ KHL + + + + CG + S P+D+ + R+ + RA G
Sbjct: 198 SLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
Query: 269 HVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
V YKG +D ++ + EG +KG P+ L+ F +YE
Sbjct: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 84.7 bits (208), Expect = 1e-16
Identities = 61/204 (29%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 21 VIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIK 80
++H+ S + E S FV GGLA+ +A PVD+ +TR QG+
Sbjct: 106 LVHRGSVYDAREFS----VHFVCGGLAACMATLTVHPVDVLRTRFAAQGE-------PKV 154
Query: 81 YRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLF-----VERLED 135
Y + HA+ + + EG Y G+AP L+ Y ++ Y SLK L+ E ++
Sbjct: 155 YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN 214
Query: 136 ETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSF----------IDIY 185
E L N++CG +GVIS T+ P D+ K R+Q G + G +
Sbjct: 215 ENLQ-NLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVL 273
Query: 186 QQEGTRGLWRGVVPTAQRAAIVVG 209
Q+EG G ++G+ P+ +AA+ G
Sbjct: 274 QKEGALGFFKGLSPSLLKAALSTG 297
Score = 29.6 bits (65), Expect = 3.8
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 237 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVD---LYKGTVDGILKMWKHEGFFALY 293
V+ GL +P DV++ R Q + D Y G + ++ + EG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 294 KGFWPNWLRLGPWNIIFFITYEQLKRL 320
KG P + + + F+++E L L
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.141 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,481,076
Number of Sequences: 37866
Number of extensions: 402438
Number of successful extensions: 1813
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1075
Number of HSP's gapped (non-prelim): 209
length of query: 322
length of database: 18,247,518
effective HSP length: 102
effective length of query: 220
effective length of database: 14,385,186
effective search space: 3164740920
effective search space used: 3164740920
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.