Search of human proteins with 4759034

Search of human proteins with 4759034

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4759034 eukaryotic translation termination factor 1 [Homo
sapiens]
         (437 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4759034 eukaryotic translation termination factor 1 [Homo sap...   866   0.0  
gi|52694665 zinc finger and BTB domain containing 20 [Homo sapiens]    32   1.1  
gi|20357552 cortactin isoform a [Homo sapiens]                         32   1.5  
gi|20357556 cortactin isoform b [Homo sapiens]                         32   1.5  
gi|38570156 5'-nucleotidase, cytosolic II-like 1 protein [Homo s...    32   1.5  
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [...    31   1.9  
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [...    31   1.9  
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]      31   1.9  
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ...    31   2.5  
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            31   2.5  
gi|130977759 tec protein tyrosine kinase [Homo sapiens]                30   4.3  
gi|18158228 zinc finger protein 280A [Homo sapiens]                    29   7.4  
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa...    29   9.6  

>gi|4759034 eukaryotic translation termination factor 1 [Homo
           sapiens]
          Length = 437

 Score =  866 bits (2238), Expect = 0.0
 Identities = 437/437 (100%), Positives = 437/437 (100%)

Query: 1   MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS 60
           MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS
Sbjct: 1   MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS 60

Query: 61  NIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPI 120
           NIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPI
Sbjct: 61  NIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPI 120

Query: 121 NTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKH 180
           NTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKH
Sbjct: 121 NTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKH 180

Query: 181 GRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSD 240
           GRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSD
Sbjct: 181 GRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSD 240

Query: 241 MFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGK 300
           MFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGK
Sbjct: 241 MFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGK 300

Query: 301 YCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDK 360
           YCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDK
Sbjct: 301 YCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDK 360

Query: 361 ETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQ 420
           ETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQ
Sbjct: 361 ETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQ 420

Query: 421 GMEYQGGDDEFFDLDDY 437
           GMEYQGGDDEFFDLDDY
Sbjct: 421 GMEYQGGDDEFFDLDDY 437


>gi|52694665 zinc finger and BTB domain containing 20 [Homo sapiens]
          Length = 668

 Score = 32.0 bits (71), Expect = 1.1
 Identities = 37/143 (25%), Positives = 58/143 (40%), Gaps = 18/143 (12%)

Query: 192 RLRMEKRHNYVRKVAETA-----------VQLFISGDKVNVAGLVLAGSADF---KTELS 237
           R+     HN+   V ET            V + I G  +     VLA  + F   K  L 
Sbjct: 4   RIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG 63

Query: 238 QSDMFDQRLQS--KVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEIS 295
            SD+    + S   V KL+D  Y G    +Q+  L  ++L+    +Q K +I      +S
Sbjct: 64  YSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEAL--QILTAASILQIKTVIDECTRIVS 121

Query: 296 QDTGKYCFGVEDTLKALEMGAVE 318
           Q+ G    G++D+ +    G  E
Sbjct: 122 QNVGDVFPGIQDSGQDTPRGTPE 144


>gi|20357552 cortactin isoform a [Homo sapiens]
          Length = 550

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 2/47 (4%)

Query: 393 TDKSQEGSQFVKGFGGIGGILRYRVDFQ--GMEYQGGDDEFFDLDDY 437
           T+K +    + KGFGG  GI + +VD    G EYQG  ++     DY
Sbjct: 182 TEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDY 228



 Score = 29.3 bits (64), Expect = 7.4
 Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 19/106 (17%)

Query: 350 QEKDKSHFTDKETGQEHELIESMPLLEWFANNYK---KFGATLEIVTDKSQEGSQF---- 402
           QE    H   +   QEH+ ++   L      ++    KFG   + + DKS  G ++    
Sbjct: 50  QEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRM-DKSAVGHEYQSKL 108

Query: 403 ---------VKGFGGIGGILRYRVDFQ--GMEYQGGDDEFFDLDDY 437
                    V+GFGG  G+   RVD    G EYQG  ++     DY
Sbjct: 109 SKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDY 154


>gi|20357556 cortactin isoform b [Homo sapiens]
          Length = 513

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 2/47 (4%)

Query: 393 TDKSQEGSQFVKGFGGIGGILRYRVDFQ--GMEYQGGDDEFFDLDDY 437
           T+K +    + KGFGG  GI + +VD    G EYQG  ++     DY
Sbjct: 182 TEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDY 228



 Score = 29.3 bits (64), Expect = 7.4
 Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 19/106 (17%)

Query: 350 QEKDKSHFTDKETGQEHELIESMPLLEWFANNYK---KFGATLEIVTDKSQEGSQF---- 402
           QE    H   +   QEH+ ++   L      ++    KFG   + + DKS  G ++    
Sbjct: 50  QEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRM-DKSAVGHEYQSKL 108

Query: 403 ---------VKGFGGIGGILRYRVDFQ--GMEYQGGDDEFFDLDDY 437
                    V+GFGG  G+   RVD    G EYQG  ++     DY
Sbjct: 109 SKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDY 154


>gi|38570156 5'-nucleotidase, cytosolic II-like 1 protein [Homo
           sapiens]
          Length = 455

 Score = 31.6 bits (70), Expect = 1.5
 Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 15/135 (11%)

Query: 260 GENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLK-----ALEM 314
           G+  F+   ++   +  N K    K+  G YF EI +D G+Y     +++K         
Sbjct: 152 GQKTFDFWKDIVAAIQHNYKMSAFKENCGIYFPEIKRDPGRYLHSCPESVKKWLRQLKNA 211

Query: 315 GAVEILIVYENLDIMR----YVLHCQGTEEEKILYLTPEQEKDKSH------FTDKETGQ 364
           G + +LI   + D  R    Y+L    T+   I+     +    SH      F   E  +
Sbjct: 212 GKILLLITSSHSDYCRLLCEYILGNDFTDLFDIVITNALKPGFFSHLPSQRPFRTLENDE 271

Query: 365 EHELIESMPLLEWFA 379
           E E + S+    W++
Sbjct: 272 EQEALPSLDKPGWYS 286


>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
           [Homo sapiens]
          Length = 938

 Score = 31.2 bits (69), Expect = 1.9
 Identities = 31/148 (20%), Positives = 59/148 (39%), Gaps = 7/148 (4%)

Query: 13  EIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVL 72
           E +  ++++ S  ++    +   S I    D IS       D    A NI  ++    + 
Sbjct: 498 EFFDAQEVLLSASSSENEASDDESYISDVSDNISE------DNTSVADNISRQILNGELT 551

Query: 73  GAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKE-KKVNIDFEPFKPINTSLYLCDNKF 131
           G      +R  L    P    +     +    GK+  KV++  E  +P+NT  +LC+   
Sbjct: 552 GGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEME 611

Query: 132 HTEALTALLSDDSKFGFIVIDGSGALFG 159
           ++E L      D  +  +V+  + A+ G
Sbjct: 612 YSELLDKASETDDPYERMVLVAAFAVSG 639


>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
           [Homo sapiens]
          Length = 934

 Score = 31.2 bits (69), Expect = 1.9
 Identities = 31/148 (20%), Positives = 59/148 (39%), Gaps = 7/148 (4%)

Query: 13  EIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVL 72
           E +  ++++ S  ++    +   S I    D IS       D    A NI  ++    + 
Sbjct: 494 EFFDAQEVLLSASSSENEASDDESYISDVSDNISE------DNTSVADNISRQILNGELT 547

Query: 73  GAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKE-KKVNIDFEPFKPINTSLYLCDNKF 131
           G      +R  L    P    +     +    GK+  KV++  E  +P+NT  +LC+   
Sbjct: 548 GGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEME 607

Query: 132 HTEALTALLSDDSKFGFIVIDGSGALFG 159
           ++E L      D  +  +V+  + A+ G
Sbjct: 608 YSELLDKASETDDPYERMVLVAAFAVSG 635


>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
          Length = 1992

 Score = 31.2 bits (69), Expect = 1.9
 Identities = 22/83 (26%), Positives = 35/83 (42%), Gaps = 11/83 (13%)

Query: 282  QEKKLIGRYFDEISQDTG--------KYCFGVEDTLKALEMGA---VEILIVYENLDIMR 330
            Q  K + RYF   + D          + C   E     ++ GA   VEI  +    D+  
Sbjct: 1096 QAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSS 1155

Query: 331  YVLHCQGTEEEKILYLTPEQEKD 353
            + +   G  ++ +LYLT + EKD
Sbjct: 1156 FEIQHSGFVKQLLLYLTSKSEKD 1178


>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
            sapiens]
          Length = 2671

 Score = 30.8 bits (68), Expect = 2.5
 Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 31/158 (19%)

Query: 260  GENGFNQAIELSTE------VLSNVKFIQEKKLIG---------RYFDEISQDTGKYCFG 304
            G N +  A++LS        +L  VK IQE++  G         +   ++ + +      
Sbjct: 2050 GHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEE 2109

Query: 305  VEDTLKALEMGAVEILIVYENLDIMRYVLHCQG-----TEEEKI-LYLTPEQEK------ 352
             ED L   E    +I IV ++  + + V    G     TEE K  L+ T EQ++      
Sbjct: 2110 EEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVS 2169

Query: 353  ---DKSHFTDKETGQEHELIESMPLLEWFANNYKKFGA 387
               D+S F   E   + +L  SMPL+ WF+     +G+
Sbjct: 2170 DFFDQSSFLHNEMEWQRKL-RSMPLIYWFSRRMTLWGS 2206


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 30.8 bits (68), Expect = 2.5
 Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 4/86 (4%)

Query: 180  HGRGGQSA-LRFARLRMEK---RHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTE 235
            +G GGQ A  + ++  ME+   R  +  +VAE  V  F + D++ V    L GS D    
Sbjct: 2438 YGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLS 2497

Query: 236  LSQSDMFDQRLQSKVLKLVDISYGGE 261
            L +     ++LQ K+L+ ++   G E
Sbjct: 2498 LQEQLTDVEKLQGKLLEEIEFLEGAE 2523


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score = 30.0 bits (66), Expect = 4.3
 Identities = 29/105 (27%), Positives = 42/105 (40%), Gaps = 17/105 (16%)

Query: 125 YLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGG 184
           + C N   ++A   L S+D + GF+V D S                 +TV L  K G  G
Sbjct: 247 WYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQP-------------GLYTVSLYTKFGGEG 293

Query: 185 QSALRFARLR----MEKRHNYVRKVAETAVQLFISGDKVNVAGLV 225
            S  R   ++      K++    K A  ++   I   K N AGLV
Sbjct: 294 SSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLV 338


>gi|18158228 zinc finger protein 280A [Homo sapiens]
          Length = 542

 Score = 29.3 bits (64), Expect = 7.4
 Identities = 19/78 (24%), Positives = 36/78 (46%), Gaps = 12/78 (15%)

Query: 217 DKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELS----- 271
           ++ N +GL +    D  +  SQ+  FD + ++ ++ L +  YG   G  Q  + +     
Sbjct: 243 ERANESGLAMT---DISSLASQNKTFDPKKENPIVLLSNFYYGQHKGDGQPEQKTHTTFK 299

Query: 272 ----TEVLSNVKFIQEKK 285
                +VL N+KF+   K
Sbjct: 300 CLSCVKVLKNIKFMNHMK 317


>gi|38348304 von Willebrand factor A domain containing 2 [Homo
           sapiens]
          Length = 725

 Score = 28.9 bits (63), Expect = 9.6
 Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 9/120 (7%)

Query: 54  DEFGTASNIKSRVNRLSVLGAITSVQQRLK--LYNKVP--PNGLVVYCGTIVTEEGKEKK 109
           D F T   +K+R+ R+   G  T  +  LK  L+  +P   N  V     IVT+   +  
Sbjct: 106 DSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGD 165

Query: 110 VNIDFEPFKPINTSLYLCDNKF-HTEALTALLSDDSKFGFI----VIDGSGALFGTLQGN 164
           V +  +  K    +++    +F   E L AL S+      +    V D +  LF TL  +
Sbjct: 166 VALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSS 225


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,018,560
Number of Sequences: 37866
Number of extensions: 619156
Number of successful extensions: 1441
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1429
Number of HSP's gapped (non-prelim): 26
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.