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Search of human proteins with 4758696
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758696 mitogen-activated protein kinase kinase kinase 13
[Homo sapiens]
(966 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 1972 0.0
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 844 0.0
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 260 5e-69
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 254 3e-67
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 244 2e-64
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 244 2e-64
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 209 1e-53
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 206 1e-52
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 151 3e-36
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 151 3e-36
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 151 3e-36
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 151 3e-36
gi|33188459 B-Raf [Homo sapiens] 148 3e-35
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 148 3e-35
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 148 3e-35
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 145 2e-34
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 145 2e-34
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 145 2e-34
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 145 2e-34
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 145 2e-34
gi|4503787 fyn-related kinase [Homo sapiens] 144 4e-34
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 142 2e-33
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 142 2e-33
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 142 2e-33
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 142 2e-33
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 142 2e-33
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 142 2e-33
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 142 2e-33
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 142 2e-33
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 142 2e-33
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 1972 bits (5109), Expect = 0.0
Identities = 966/966 (100%), Positives = 966/966 (100%)
Query: 1 MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV 60
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
Sbjct: 1 MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV 60
Query: 61 HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF 120
HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
Sbjct: 61 HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF 120
Query: 121 SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG 180
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
Sbjct: 121 SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG 180
Query: 181 AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 240
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
Sbjct: 181 AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 240
Query: 241 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT 300
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
Sbjct: 241 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT 300
Query: 301 SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA 360
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
Sbjct: 301 SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA 360
Query: 361 IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE 420
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
Sbjct: 361 IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE 420
Query: 421 TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN 480
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
Sbjct: 421 TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN 480
Query: 481 NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH 540
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
Sbjct: 481 NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH 540
Query: 541 KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS 600
KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
Sbjct: 541 KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS 600
Query: 601 DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG 660
DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
Sbjct: 601 DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG 660
Query: 661 QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP 720
QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
Sbjct: 661 QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP 720
Query: 721 WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE 780
WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
Sbjct: 721 WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE 780
Query: 781 FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS 840
FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
Sbjct: 781 FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS 840
Query: 841 SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS 900
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
Sbjct: 841 SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS 900
Query: 901 SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH 960
SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
Sbjct: 901 SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH 960
Query: 961 YSSATW 966
YSSATW
Sbjct: 961 YSSATW 966
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 844 bits (2180), Expect = 0.0
Identities = 482/891 (54%), Positives = 582/891 (65%), Gaps = 83/891 (9%)
Query: 70 TSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGG 129
TS +D VLQL E D + G+ + S +++++Q +SGSG
Sbjct: 33 TSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPES--RASRVRADEVRLQ-CQSGSG--- 86
Query: 130 FLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRA 189
FLEGLFGCLRPVW +IGKAYST++K QQ+D WEVPFEEI +LQW+GSGAQGAVFLG+F
Sbjct: 87 FLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHG 146
Query: 190 EEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR 249
EEVA+KKVR+ ETDIKHLRKLKHPNII FKGVCTQAPCYCI+ME+CA GQLYEVLRAGR
Sbjct: 147 EEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGR 206
Query: 250 KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 309
+TP LLVDWS GIA GMNYLHLHKIIHRDLKSPN+L+T+ D VKISDFGTSKELSDKST
Sbjct: 207 PVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKST 266
Query: 310 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS 369
KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS
Sbjct: 267 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS 326
Query: 370 LHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEW 429
LHLPVPS+CPDGFKIL++Q W SKPRNRPSFRQ L+HLDIASADVL+TPQETYFKSQAEW
Sbjct: 327 LHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEW 386
Query: 430 REEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAI 489
REEVK HFEKIKSEGTC+HRL+EEL+ RRREELRHALDIREHYERKLERANNLYMEL+A+
Sbjct: 387 REEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNAL 446
Query: 490 MLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRP 549
MLQLE++E+EL++REQA+E++ PG K HP R ++H N MEKL+K++ VP K +KRP
Sbjct: 447 MLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRP 506
Query: 550 DLLRSEG-IPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDF----AA 604
D+L++E +P + A + L G PK S +SR R K RHR+ +++GS D A
Sbjct: 507 DILKTESLLPKLDAALSGVGLPGCPKAPPSPGRSR-RGKTRHRKASAKGSCGDLPGLRTA 565
Query: 605 ILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIA 664
+ ++P SP PS ++ PPA+ HH L
Sbjct: 566 VPPHEPGGPGSP------GGLGGGPS---------AWEACPPALRGLHHDLL-------- 602
Query: 665 TCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCC 724
R++ SSPDL+S A+ + +G+ G
Sbjct: 603 -----------------------LRKMSSSSPDLLSAALGS---------RGRGATGGAG 630
Query: 725 QADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGC 784
+ P P GS S P SP +K P+ E +
Sbjct: 631 DPGSPPPARGDTPPSEGSAP-GSTSP--DSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 687
Query: 785 RSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQS 844
R S G+ HL L R + SSEEEEGEVDSEVE QR + ++ QS
Sbjct: 688 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 747
Query: 845 YSTFSSENFSVSDGEEGNTSDHSNS--PDELADKLEDRLAEKLDDLLSQTPEIPIDISSH 902
STFSSEN SDGEEG S+ S S P+ + ++R E+ DD+ SQ EIP+D
Sbjct: 748 LSTFSSEN--PSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLD-PPP 804
Query: 903 SDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDA 953
S+ + E + + Q L ERG P E+SDCDS++ + S++
Sbjct: 805 SEVIPGPEPSSLPIPHQELL-----RERG---PPNSEDSDCDSTELDNSNS 847
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 260 bits (664), Expect = 5e-69
Identities = 169/473 (35%), Positives = 244/473 (51%), Gaps = 66/473 (13%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETD-----------IKHLRK 210
E+PF E+ + +G G G V+ +R EEVA+K R E D +
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 270
L+HPNIIA +G C P C++MEY G L VL AGR++ P +LV+W+ +A GMNYL
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
Query: 271 HLHK---IIHRDLKSPNVLVTHT--------DAVKISDFGTSKELSDKSTKMSFAGTVAW 319
H IIHRDLKS N+L+ +KI+DFG ++E K+TKMS AGT AW
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH-KTTKMSAAGTYAW 269
Query: 320 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
MAPEVIR S+ D+WSFGV+LWELLTGE+PY+++D+ A+ +GV N L LP+PSTCP
Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
Query: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVL-ATPQETYFKSQAEWREEVKKHFE 438
+ F L+++ W P RP F L L++ L P E++ Q +W+ E++ F+
Sbjct: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
Query: 439 KIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLY-MELSAIMLQLEMRE 497
++++ + +EEL+R +E+ +R + ER ++ EL +M QL +
Sbjct: 390 DLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEK 449
Query: 498 KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMK-RKGVPH---KSGMQTKRPDLLR 553
+ KR+ G +KR +L+K R+G H SG + K
Sbjct: 450 PRVRKRK--------GNFKR------------SRLLKLREGGSHISLPSGFEHK------ 483
Query: 554 SEGIPTTEVAPTASPLSGSPKMSTSSSKS------RYRSKPRHRRGNSRGSHS 600
T + +PT GS S +S S R P G+S GS S
Sbjct: 484 ----ITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSS 532
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 254 bits (649), Expect = 3e-67
Identities = 156/427 (36%), Positives = 230/427 (53%), Gaps = 38/427 (8%)
Query: 165 FEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKLKH 213
F+E+ + +G G G V+ G +R E VA+K R+ + DI + L H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 214 PNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH-- 271
PNIIA K VC + P C++MEY A G L L AGR++ P +LV+W+ IA GM+YLH
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCE 232
Query: 272 -LHKIIHRDLKSPNVLVTHT--------DAVKISDFGTSKELSDKSTKMSFAGTVAWMAP 322
L +IHRDLKS N+L+ +KI+DFG ++E K+T+MS AGT AWMAP
Sbjct: 233 ALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH-KTTQMSAAGTYAWMAP 291
Query: 323 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
EVI+ S+ D+WSFGV+LWELLTGE+PY+ +D A+ +GV N L LP+PSTCP+ F
Sbjct: 292 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 351
Query: 383 KILMKQTWQSKPRNRPSFRQTLMHLDIASADVL-ATPQETYFKSQAEWREEVKKHFEKIK 441
LM W P RP F L L+ A VL P++++ Q W+ E++ F++++
Sbjct: 352 AQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELR 411
Query: 442 SEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELI 501
++ + +EEL R RE+ A +R + ++ ++LQ RE+ +
Sbjct: 412 AKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHV 471
Query: 502 KREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTE 561
+R + GT+KR +R + E++ H+ +Q P L R + E
Sbjct: 472 RRRR-------GTFKRSKLRA---RDGGERISMPLDFKHRITVQAS-PGLDRRRNV--FE 518
Query: 562 VAPTASP 568
V P SP
Sbjct: 519 VGPGDSP 525
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 244 bits (624), Expect = 2e-64
Identities = 156/449 (34%), Positives = 239/449 (53%), Gaps = 62/449 (13%)
Query: 163 VPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKL 211
V FE + + +G+G G V+ ++ +EVA+K R+ E D + L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 212 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL--------------RAGRKITPRLLV 257
+HPNII +GVC Q P C+++E+ G L L R R+I P +LV
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 258 DWSTGIASGMNYLHLHK---IIHRDLKSPNVL----VTHTD----AVKISDFGTSKELSD 306
+W+ IA GM YLH I+HRDLKS N+L + H D +KI+DFG ++E
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH- 297
Query: 307 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG 366
++TKMS AGT AWMAPEVI++ S+ DIWS+GV+LWELLTGE+PY+ +D A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 367 SNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD-IASADVLATPQETYFKS 425
N L LP+PSTCP+ F LMK+ WQ P RPSF L L I A + PQE++
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 426 QAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYME 485
Q +W+ E+++ F++++++ E+ +R R EEL A ++ E L+R E
Sbjct: 418 QDDWKLEIQQMFDELRTK--------EKELRSREEELTRAALQQKSQEELLKRREQQLAE 469
Query: 486 LSAIMLQLEMREKEL------IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVP 539
++++ E+EL + +E+ KK G +KR ++ ++
Sbjct: 470 -----REIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLK----LKDGHRISLPSDFQ 520
Query: 540 HKSGMQTKRPDLLRSEGIPTTEVAPTASP 568
HK +Q P+L + + ++ +P +SP
Sbjct: 521 HKITVQAS-PNLDKRRSLNSSSSSPPSSP 548
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 244 bits (624), Expect = 2e-64
Identities = 142/373 (38%), Positives = 215/373 (57%), Gaps = 27/373 (7%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRK 210
E+ F E++ + +G G G V+ + +EVA+K R + DI K
Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 270
LKHPNIIA +GVC + P C++ME+ G L VL +G++I P +LV+W+ IA GMNYL
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 256
Query: 271 H---LHKIIHRDLKSPNVLVTH--------TDAVKISDFGTSKELSDKSTKMSFAGTVAW 319
H + IIHRDLKS N+L+ +KI+DFG ++E ++TKMS AGT AW
Sbjct: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH-RTTKMSAAGTYAW 315
Query: 320 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
MAPEVIR S+ D+WS+GV+LWELLTGE+P++ +D A+ +GV N L LP+PSTCP
Sbjct: 316 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 375
Query: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHL-DIASADVLATPQETYFKSQAEWREEVKKHFE 438
+ F LM+ W P +RPSF L L I + P++++ Q W+ E+++ F+
Sbjct: 376 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 435
Query: 439 KIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLER-ANNLYMELSAIMLQLEMRE 497
+++++ + +EEL R ++ +R + ER + L EL+ I+ QL +E
Sbjct: 436 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQL-CQE 494
Query: 498 KELIKREQAVEKK 510
K +K+ + +K
Sbjct: 495 KPRVKKRKGKFRK 507
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 209 bits (531), Expect = 1e-53
Identities = 133/402 (33%), Positives = 217/402 (53%), Gaps = 28/402 (6%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLRKLKHPNIIAF 219
++ F+++ + G G+ G+V+ K+ ++ EVA+KK+ + E + + L L H NII F
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
Query: 220 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLH---K 274
GV + P Y I+ EY + G LY+ + + R + ++ W+T +A GM+YLH+ K
Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
Query: 275 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 334
+IHRDLKS NV++ +KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
Query: 335 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 394
D +S+GVVLWE+LT E+P+K ++ + W V + L +PS+CP F L+ Q W++
Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
Query: 395 RNRPSFRQTLMHLDIASADV-LATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEE 453
+ RPSF+Q + L+ S D L ++ ++AEWR E++ E++K + ++E
Sbjct: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
Query: 454 LIRRRREELRHALDIREHYERKLERANN--LYMELSAIMLQ---LEMREKELIKREQAVE 508
L R R + +E+KL +N L + L+A M + E + +E E + +
Sbjct: 308 LKERERR--------LKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQ 359
Query: 509 KKYPGTYKRHPVRPIIHPNAMEKL-----MKRKGVPHKSGMQ 545
+ H + P + + M + G SGMQ
Sbjct: 360 ITATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQ 401
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 206 bits (523), Expect = 1e-52
Identities = 114/306 (37%), Positives = 182/306 (59%), Gaps = 10/306 (3%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLRKLKHPNIIAF 219
++ F+++ + G G+ G+V+ K+ ++ EVA+KK+ + E + + L L H NII F
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
Query: 220 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLH---K 274
GV + P Y I+ EY + G LY+ + + R + ++ W+T +A GM+YLH+ K
Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
Query: 275 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 334
+IHRDLKS NV++ +KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
Query: 335 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 394
D +S+GVVLWE+LT E+P+K ++ + W V + L +PS+CP F L+ Q W++
Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
Query: 395 RNRPSFRQTLMHLDIASADV-LATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEE 453
+ RPSF+Q + L+ S D L ++ ++AEWR E++ E++K + ++E
Sbjct: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
Query: 454 LIRRRR 459
L R R
Sbjct: 308 LKERER 313
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 151 bits (381), Expect = 3e-36
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216
E+ ++EI + +G GA G V K+RA++VAIK++ ++E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273
+ G C C++MEY G LY VL + T + W + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329
+ +IHRDLK PN+L+ V KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ P + LM
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 388 QTWQSKPRNRPSFRQ 402
+ W P RPS +
Sbjct: 265 RCWSKDPSQRPSMEE 279
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 151 bits (381), Expect = 3e-36
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216
E+ ++EI + +G GA G V K+RA++VAIK++ ++E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273
+ G C C++MEY G LY VL + T + W + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329
+ +IHRDLK PN+L+ V KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ P + LM
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 388 QTWQSKPRNRPSFRQ 402
+ W P RPS +
Sbjct: 265 RCWSKDPSQRPSMEE 279
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 151 bits (381), Expect = 3e-36
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216
E+ ++EI + +G GA G V K+RA++VAIK++ ++E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273
+ G C C++MEY G LY VL + T + W + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329
+ +IHRDLK PN+L+ V KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ P + LM
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 388 QTWQSKPRNRPSFRQ 402
+ W P RPS +
Sbjct: 265 RCWSKDPSQRPSMEE 279
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 151 bits (381), Expect = 3e-36
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216
E+ ++EI + +G GA G V K+RA++VAIK++ ++E +++ L ++ HPNI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273
+ G C C++MEY G LY VL + T + W + G+ YLH
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329
+ +IHRDLK PN+L+ V KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
Query: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ P + LM
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
Query: 388 QTWQSKPRNRPSFRQ 402
+ W P RPS +
Sbjct: 265 RCWSKDPSQRPSMEE 279
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 148 bits (373), Expect = 3e-35
Identities = 105/290 (36%), Positives = 152/290 (52%), Gaps = 27/290 (9%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLR 209
D WE+P +I+ Q +GSG+ G V+ GK+ + VA+K + T ++ LR
Sbjct: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGVLR 506
Query: 210 KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMN 268
K +H NI+ F G T+ P I+ ++C LY L K L+D + A GM+
Sbjct: 507 KTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMD 565
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF---AGTVAWMAPEVI 325
YLH IIHRDLKS N+ + VKI DFG + S S F +G++ WMAPEVI
Sbjct: 566 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 625
Query: 326 R---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LPVPSTC 378
R P S + D+++FG+VL+EL+TG++PY ++++ II+ VG L V S C
Sbjct: 626 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC 685
Query: 379 PDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAE 428
P K LM + + K RP F Q L AS ++LA +S +E
Sbjct: 686 PKAMKRLMAECLKKKRDERPLFPQIL-----ASIELLARSLPKIHRSASE 730
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 148 bits (373), Expect = 3e-35
Identities = 91/260 (35%), Positives = 143/260 (55%), Gaps = 14/260 (5%)
Query: 161 WEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNETD------IKHLRKLKH 213
WE+ EEI+ L+ LGSG G V LGK++ + +VA+K ++E + ++ + + KL H
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
Query: 214 PNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHL 272
P ++ F GVC++ I+ EY ++G L LR+ G+ + P L++ + GM +L
Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 529
Query: 273 HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEP 329
H+ IHRDL + N LV VK+SDFG ++ + D +S GT V W APEV
Sbjct: 530 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLD-DQYVSSVGTKFPVKWSAPEVFHYFK 588
Query: 330 VSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQ 388
S K D+W+FG+++WE+ + G+ PY D+S ++ V S L P D +M
Sbjct: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 647
Query: 389 TWQSKPRNRPSFRQTLMHLD 408
W P RP+F+Q L ++
Sbjct: 648 CWHELPEKRPTFQQLLSSIE 667
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 148 bits (373), Expect = 3e-35
Identities = 91/260 (35%), Positives = 143/260 (55%), Gaps = 14/260 (5%)
Query: 161 WEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNETD------IKHLRKLKH 213
WE+ EEI+ L+ LGSG G V LGK++ + +VA+K ++E + ++ + + KL H
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
Query: 214 PNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHL 272
P ++ F GVC++ I+ EY ++G L LR+ G+ + P L++ + GM +L
Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 529
Query: 273 HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEP 329
H+ IHRDL + N LV VK+SDFG ++ + D +S GT V W APEV
Sbjct: 530 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLD-DQYVSSVGTKFPVKWSAPEVFHYFK 588
Query: 330 VSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQ 388
S K D+W+FG+++WE+ + G+ PY D+S ++ V S L P D +M
Sbjct: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 647
Query: 389 TWQSKPRNRPSFRQTLMHLD 408
W P RP+F+Q L ++
Sbjct: 648 CWHELPEKRPTFQQLLSSIE 667
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 145 bits (365), Expect = 2e-34
Identities = 90/259 (34%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V++G ++ VA+K ++E E +K +++
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 323
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT P + I+ EY +G L + LR + +T +L+ +T I+S M
Sbjct: 324 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 383
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 384 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 442
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYE 501
Query: 385 LMKQTWQSKPRNRPSFRQT 403
LM+ W+ P +RPSF +T
Sbjct: 502 LMRACWKWSPADRPSFAET 520
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 145 bits (365), Expect = 2e-34
Identities = 90/259 (34%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V++G ++ VA+K ++E E +K +++
Sbjct: 279 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 338
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT P + I+ EY +G L + LR + +T +L+ +T I+S M
Sbjct: 339 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 398
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 399 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 457
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP
Sbjct: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYE 516
Query: 385 LMKQTWQSKPRNRPSFRQT 403
LM+ W+ P +RPSF +T
Sbjct: 517 LMRACWKWSPADRPSFAET 535
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 145 bits (365), Expect = 2e-34
Identities = 90/259 (34%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V++G ++ VA+K ++E E +K +++
Sbjct: 258 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 317
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT P + I+ EY +G L + LR + +T +L+ +T I+S M
Sbjct: 318 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 377
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 378 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 436
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP
Sbjct: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYE 495
Query: 385 LMKQTWQSKPRNRPSFRQT 403
LM+ W+ P +RPSF +T
Sbjct: 496 LMRACWKWSPADRPSFAET 514
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 145 bits (365), Expect = 2e-34
Identities = 90/259 (34%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V++G ++ VA+K ++E E +K +++
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 323
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT P + I+ EY +G L + LR + +T +L+ +T I+S M
Sbjct: 324 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 383
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 384 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 442
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYE 501
Query: 385 LMKQTWQSKPRNRPSFRQT 403
LM+ W+ P +RPSF +T
Sbjct: 502 LMRACWKWSPADRPSFAET 520
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 145 bits (365), Expect = 2e-34
Identities = 90/259 (34%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V++G ++ VA+K ++E E +K +++
Sbjct: 243 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 302
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT P + I+ EY +G L + LR + +T +L+ +T I+S M
Sbjct: 303 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 362
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 363 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 421
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP
Sbjct: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYE 480
Query: 385 LMKQTWQSKPRNRPSFRQT 403
LM+ W+ P +RPSF +T
Sbjct: 481 LMRACWKWSPADRPSFAET 499
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 144 bits (363), Expect = 4e-34
Identities = 91/264 (34%), Positives = 138/264 (52%), Gaps = 16/264 (6%)
Query: 152 DYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKKVR----EQNE--TD 204
D + D WE+ I L+ LGSG G V+ G + VA+K ++ + N+ +
Sbjct: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 277
Query: 205 IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR--AGRKITPRLLVDWSTG 262
+ ++ L+HP +I VCT II E HG L E L+ G KI VD +
Sbjct: 278 AQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQ 337
Query: 263 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKS-----TKMSFAGTV 317
+ASGM YL IHRDL + NVLV + K++DFG ++ + ++ V
Sbjct: 338 VASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPV 397
Query: 318 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPS 376
W APE IR+ S K D+WSFG++L+E++T G++PY + + +I + N LP PS
Sbjct: 398 KWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPS 456
Query: 377 TCPDGFKILMKQTWQSKPRNRPSF 400
CP F +M + W ++P+ RP+F
Sbjct: 457 NCPQQFYNIMLECWNAEPKERPTF 480
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 142 bits (358), Expect = 2e-33
Identities = 95/261 (36%), Positives = 136/261 (52%), Gaps = 12/261 (4%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVRE--QNETDI----KHLRKL 211
+ WE+ E++ ++ LGSG G V LGK+RA+ +VAIK +RE E D K + KL
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL 420
Query: 212 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPR-LLVDWSTGIASGMNYL 270
HP ++ GVCTQ I+ E+ G L LR + R +L+ + GM YL
Sbjct: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480
Query: 271 HLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-ELSDKSTKMSFAG-TVAWMAPEVIRNE 328
+ IHRDL + N LV+ VK+SDFG ++ L D+ T S A V W PEV
Sbjct: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
Query: 329 PVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 387
S K D+WSFGV++WE+ T G +P++ + ++ V + L P + +M
Sbjct: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEVML 599
Query: 388 QTWQSKPRNRPSFRQTLMHLD 408
+ WQ KP RPSF L +D
Sbjct: 600 RCWQEKPEGRPSFEDLLRTID 620
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 142 bits (357), Expect = 2e-33
Identities = 89/258 (34%), Positives = 137/258 (53%), Gaps = 16/258 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V+ G ++ VA+K ++E E +K +++
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT+ P + II E+ +G L + LR +++ +L+ +T I+S M
Sbjct: 293 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 411
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP+
Sbjct: 412 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYE 470
Query: 385 LMKQTWQSKPRNRPSFRQ 402
LM+ WQ P +RPSF +
Sbjct: 471 LMRACWQWNPSDRPSFAE 488
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 142 bits (357), Expect = 2e-33
Identities = 89/258 (34%), Positives = 137/258 (53%), Gaps = 16/258 (6%)
Query: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKH---LRK 210
D WE+ +I+ LG G G V+ G ++ VA+K ++E E +K +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMN 268
+KHPN++ GVCT+ P + II E+ +G L + LR +++ +L+ +T I+S M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVI 325
YL IHRDL + N LV VK++DFG S+ L T + AG + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL 430
Query: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
S K D+W+FGV+LWE+ T G PY +D S ++ + + P CP+
Sbjct: 431 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYE 489
Query: 385 LMKQTWQSKPRNRPSFRQ 402
LM+ WQ P +RPSF +
Sbjct: 490 LMRACWQWNPSDRPSFAE 507
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 142 bits (357), Expect = 2e-33
Identities = 82/255 (32%), Positives = 142/255 (55%), Gaps = 14/255 (5%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNET------DIKHLRK 210
+D WEVP E + ++ LG+G G V++G + +VA+K +++ + + + +++
Sbjct: 235 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 294
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR--AGRKITPRLLVDWSTGIASGMN 268
L+H ++ V TQ P Y II EY +G L + L+ +G K+T L+D + IA GM
Sbjct: 295 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMSFAGTVAWMAPEVIR 326
++ IHRDL++ N+LV+ T + KI+DFG ++ + D + + + W APE I
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 327 NEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKIL 385
+ K D+WSFG++L E++T G IPY + + +I + + P CP+ L
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 472
Query: 386 MKQTWQSKPRNRPSF 400
M+ W+ +P +RP+F
Sbjct: 473 MRLCWKERPEDRPTF 487
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 142 bits (357), Expect = 2e-33
Identities = 82/255 (32%), Positives = 142/255 (55%), Gaps = 14/255 (5%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNET------DIKHLRK 210
+D WEVP E + ++ LG+G G V++G + +VA+K +++ + + + +++
Sbjct: 235 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 294
Query: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR--AGRKITPRLLVDWSTGIASGMN 268
L+H ++ V TQ P Y II EY +G L + L+ +G K+T L+D + IA GM
Sbjct: 295 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMSFAGTVAWMAPEVIR 326
++ IHRDL++ N+LV+ T + KI+DFG ++ + D + + + W APE I
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 327 NEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKIL 385
+ K D+WSFG++L E++T G IPY + + +I + + P CP+ L
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 472
Query: 386 MKQTWQSKPRNRPSF 400
M+ W+ +P +RP+F
Sbjct: 473 MRLCWKERPEDRPTF 487
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 142 bits (357), Expect = 2e-33
Identities = 93/258 (36%), Positives = 128/258 (49%), Gaps = 16/258 (6%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH-------- 207
+D W + E++ + +G G G VF G+ RA+ VA+K RE D+K
Sbjct: 423 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 482
Query: 208 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASG 266
L++ HPNI+ GVCTQ I+ME G LR G ++ + L+ A+G
Sbjct: 483 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 542
Query: 267 MNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA---GTVAWMAPE 323
M YL IHRDL + N LVT + +KISDFG S+E +D S V W APE
Sbjct: 543 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 602
Query: 324 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
+ S + D+WSFG++LWE + G PY ++ + V LP P CPD
Sbjct: 603 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPELCPDAV 661
Query: 383 KILMKQTWQSKPRNRPSF 400
LM+Q W +P RPSF
Sbjct: 662 FRLMEQCWAYEPGQRPSF 679
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 142 bits (357), Expect = 2e-33
Identities = 93/258 (36%), Positives = 128/258 (49%), Gaps = 16/258 (6%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH-------- 207
+D W + E++ + +G G G VF G+ RA+ VA+K RE D+K
Sbjct: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
Query: 208 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASG 266
L++ HPNI+ GVCTQ I+ME G LR G ++ + L+ A+G
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
Query: 267 MNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA---GTVAWMAPE 323
M YL IHRDL + N LVT + +KISDFG S+E +D S V W APE
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 660
Query: 324 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
+ S + D+WSFG++LWE + G PY ++ + V LP P CPD
Sbjct: 661 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPELCPDAV 719
Query: 383 KILMKQTWQSKPRNRPSF 400
LM+Q W +P RPSF
Sbjct: 720 FRLMEQCWAYEPGQRPSF 737
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 142 bits (357), Expect = 2e-33
Identities = 93/258 (36%), Positives = 128/258 (49%), Gaps = 16/258 (6%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH-------- 207
+D W + E++ + +G G G VF G+ RA+ VA+K RE D+K
Sbjct: 493 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 552
Query: 208 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASG 266
L++ HPNI+ GVCTQ I+ME G LR G ++ + L+ A+G
Sbjct: 553 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 612
Query: 267 MNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA---GTVAWMAPE 323
M YL IHRDL + N LVT + +KISDFG S+E +D S V W APE
Sbjct: 613 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 672
Query: 324 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
+ S + D+WSFG++LWE + G PY ++ + V LP P CPD
Sbjct: 673 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPELCPDAV 731
Query: 383 KILMKQTWQSKPRNRPSF 400
LM+Q W +P RPSF
Sbjct: 732 FRLMEQCWAYEPGQRPSF 749
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 142 bits (357), Expect = 2e-33
Identities = 93/258 (36%), Positives = 128/258 (49%), Gaps = 16/258 (6%)
Query: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH-------- 207
+D W + E++ + +G G G VF G+ RA+ VA+K RE D+K
Sbjct: 551 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 610
Query: 208 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASG 266
L++ HPNI+ GVCTQ I+ME G LR G ++ + L+ A+G
Sbjct: 611 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 670
Query: 267 MNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA---GTVAWMAPE 323
M YL IHRDL + N LVT + +KISDFG S+E +D S V W APE
Sbjct: 671 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 730
Query: 324 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 382
+ S + D+WSFG++LWE + G PY ++ + V LP P CPD
Sbjct: 731 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPELCPDAV 789
Query: 383 KILMKQTWQSKPRNRPSF 400
LM+Q W +P RPSF
Sbjct: 790 FRLMEQCWAYEPGQRPSF 807
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,837,126
Number of Sequences: 37866
Number of extensions: 2050007
Number of successful extensions: 10888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 734
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 7825
Number of HSP's gapped (non-prelim): 1946
length of query: 966
length of database: 18,247,518
effective HSP length: 112
effective length of query: 854
effective length of database: 14,006,526
effective search space: 11961573204
effective search space used: 11961573204
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.