Search of human proteins with 4557845

Search of human proteins with 4557845

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557845 ribonucleotide reductase M2 polypeptide [Homo
sapiens]
         (389 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557845 ribonucleotide reductase M2 polypeptide [Homo sapiens]     783   0.0  
gi|42544136 ribonucleotide reductase M2 B (TP53 inducible) [Homo...   564   e-161
gi|4504777 integrin, beta 7 [Homo sapiens]                             34   0.26 
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    33   0.44 
gi|57863275 vacuolar protein sorting 8 homolog isoform b [Homo s...    30   3.7  
gi|57863277 vacuolar protein sorting 8 homolog isoform a [Homo s...    30   3.7  
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    30   3.7  
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    30   3.7  
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     30   4.9  
gi|44917619 kelch domain containing 10 [Homo sapiens]                  29   6.3  
gi|22547134 mitochondrial ribosomal protein L37 [Homo sapiens]         29   8.3  
gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens]             29   8.3  

>gi|4557845 ribonucleotide reductase M2 polypeptide [Homo sapiens]
          Length = 389

 Score =  783 bits (2021), Expect = 0.0
 Identities = 389/389 (100%), Positives = 389/389 (100%)

Query: 1   MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT 60
           MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
Sbjct: 1   MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT 60

Query: 61  KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK 120
           KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
Sbjct: 61  KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK 120

Query: 121 PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI 180
           PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
Sbjct: 121 PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI 180

Query: 181 DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF 240
           DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
Sbjct: 181 DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF 240

Query: 241 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE 300
           ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
Sbjct: 241 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE 300

Query: 301 QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN 360
           QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
Sbjct: 301 QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN 360

Query: 361 FFEKRVGEYQRMGVMSSPTENSFTLDADF 389
           FFEKRVGEYQRMGVMSSPTENSFTLDADF
Sbjct: 361 FFEKRVGEYQRMGVMSSPTENSFTLDADF 389


>gi|42544136 ribonucleotide reductase M2 B (TP53 inducible) [Homo
           sapiens]
          Length = 351

 Score =  564 bits (1454), Expect = e-161
 Identities = 269/321 (83%), Positives = 302/321 (94%)

Query: 69  DEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFIS 128
           +EPLLR++ RRFVIFPI+Y DIW+MYK+A+ASFWTAEEVDLSKD+ HW  LK +E+YFIS
Sbjct: 31  EEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFIS 90

Query: 129 HVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 188
           H+LAFFAASDGIVNENLVERFSQEVQ+ EARCFYGFQI +EN+HSEMYSLLIDTYI+DPK
Sbjct: 91  HILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPK 150

Query: 189 EREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKK 248
           +REFLFNAIETMP VKKKADWALRWI D+++T+GERVVAFAAVEG+FFSGSFA+IFWLKK
Sbjct: 151 KREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKK 210

Query: 249 RGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEAL 308
           RGLMPGLTFSNELISRDEGLHCDFACLMF++LV+KPSEERVREII++AV+IEQEFLTEAL
Sbjct: 211 RGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEAL 270

Query: 309 PVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGE 368
           PV LIGMNC LMKQYIEFVADRL++ELGFSKVF+ ENPFDFMENISLEGKTNFFEKRV E
Sbjct: 271 PVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSE 330

Query: 369 YQRMGVMSSPTENSFTLDADF 389
           YQR  VM+  T+N FTLDADF
Sbjct: 331 YQRFAVMAETTDNVFTLDADF 351


>gi|4504777 integrin, beta 7 [Homo sapiens]
          Length = 798

 Score = 33.9 bits (76), Expect = 0.26
 Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 2/115 (1%)

Query: 264 RDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQY 323
           R EG   D   LM      K   ERVR++  +A+ +  + +T ++ +         +  +
Sbjct: 146 RAEGYPVDLYYLMDLSYSMKDDLERVRQLG-HALLVRLQEVTHSVRIGFGSFVDKTVLPF 204

Query: 324 IEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSP 378
           +  V  +L      +++ R ++PF F   +SL G    FE+ VG     G + SP
Sbjct: 205 VSTVPSKLRHPCP-TRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSP 258


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 33.1 bits (74), Expect = 0.44
 Identities = 25/68 (36%), Positives = 36/68 (52%), Gaps = 10/68 (14%)

Query: 1   MLSLRVPLAPI--TDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEP 58
           M++LR P   I  T PQQ+QL+PL+ + +V     P  L GT+ L++ +A    Q     
Sbjct: 765 MVALRQPHNRIMLTTPQQIQLNPLQPVPVV----KPAVLPGTKALSAVSA----QAAAAQ 816

Query: 59  KTKAAAPG 66
           K K   PG
Sbjct: 817 KNKLKEPG 824


>gi|57863275 vacuolar protein sorting 8 homolog isoform b [Homo
            sapiens]
          Length = 1426

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 29/126 (23%), Positives = 53/126 (42%), Gaps = 9/126 (7%)

Query: 150  SQEVQITEARCFYGF-QIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKAD 208
            S+ +++ E   FY   +   E  H   Y  +ID Y++DP   E +FN I  +  +   + 
Sbjct: 892  SRLIRMAEKAEFYQICEFMYEREHQ--YDKIIDCYLRDPLREEEVFNYIHNILSIPGHSA 949

Query: 209  WALRWIGDKEATYGERVVAF-----AAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELIS 263
               + +  K   + E +V+      A +    FSG   ++   K +  +    F   L+ 
Sbjct: 950  EEKQSVWQKAMDHIEELVSLKPCKAAELVATHFSGHIETVI-KKLQNQVLLFKFLRSLLD 1008

Query: 264  RDEGLH 269
              EG+H
Sbjct: 1009 PREGIH 1014


>gi|57863277 vacuolar protein sorting 8 homolog isoform a [Homo
            sapiens]
          Length = 1428

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 29/126 (23%), Positives = 53/126 (42%), Gaps = 9/126 (7%)

Query: 150  SQEVQITEARCFYGF-QIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKAD 208
            S+ +++ E   FY   +   E  H   Y  +ID Y++DP   E +FN I  +  +   + 
Sbjct: 894  SRLIRMAEKAEFYQICEFMYEREHQ--YDKIIDCYLRDPLREEEVFNYIHNILSIPGHSA 951

Query: 209  WALRWIGDKEATYGERVVAF-----AAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELIS 263
               + +  K   + E +V+      A +    FSG   ++   K +  +    F   L+ 
Sbjct: 952  EEKQSVWQKAMDHIEELVSLKPCKAAELVATHFSGHIETVI-KKLQNQVLLFKFLRSLLD 1010

Query: 264  RDEGLH 269
              EG+H
Sbjct: 1011 PREGIH 1016


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 27/98 (27%), Positives = 40/98 (40%), Gaps = 25/98 (25%)

Query: 12  TDPQQLQLSPL---------KGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKA 62
           T+P    LSP          +G+   D+E+TP   S  R+L S T   +   P +PK + 
Sbjct: 189 TEPLPRTLSPTPASATAPTSQGIPTSDEESTPKK-SKARILESITVSSLMATPQDPKGQG 247

Query: 63  --------------AAPGVEDEPLLRENP-RRFVIFPI 85
                          +PG  D P   ++P R  V+ PI
Sbjct: 248 VGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPI 285


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 27/98 (27%), Positives = 40/98 (40%), Gaps = 25/98 (25%)

Query: 12  TDPQQLQLSPL---------KGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKA 62
           T+P    LSP          +G+   D+E+TP   S  R+L S T   +   P +PK + 
Sbjct: 189 TEPLPRTLSPTPASATAPTSQGIPTSDEESTPKK-SKARILESITVSSLMATPQDPKGQG 247

Query: 63  --------------AAPGVEDEPLLRENP-RRFVIFPI 85
                          +PG  D P   ++P R  V+ PI
Sbjct: 248 VGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPI 285


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 12/40 (30%), Positives = 21/40 (52%)

Query: 164 FQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCV 203
           F  A   + + MY+L +   IKDPK+ +F++       C+
Sbjct: 335 FSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCL 374


>gi|44917619 kelch domain containing 10 [Homo sapiens]
          Length = 442

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 16/42 (38%), Positives = 20/42 (47%)

Query: 34  PPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRE 75
           PPA SG R +A  T   +F        ++  P  ED PL RE
Sbjct: 89  PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRE 130


>gi|22547134 mitochondrial ribosomal protein L37 [Homo sapiens]
          Length = 423

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 12/114 (10%)

Query: 208 DWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMP------GLTFSNEL 261
           +W +R     E    +RV     +E I F+G    + WL +    P         F    
Sbjct: 32  EWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDRGYKDPRFYRSP 91

Query: 262 ISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGM 315
              +  L+ D AC +F H        R+ E +  A+ + +  L E LP K++ +
Sbjct: 92  PLHEHPLYKDQACYIFHHRC------RLLEGVKQALWLTKTKLIEGLPEKVLSL 139


>gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens]
          Length = 694

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 16/48 (33%), Positives = 21/48 (43%)

Query: 14  PQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTK 61
           P     S L  L+ V K  + PAL  T    S++ R+    P  PK K
Sbjct: 398 PSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAK 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,212,692
Number of Sequences: 37866
Number of extensions: 612371
Number of successful extensions: 1324
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1317
Number of HSP's gapped (non-prelim): 13
length of query: 389
length of database: 18,247,518
effective HSP length: 104
effective length of query: 285
effective length of database: 14,309,454
effective search space: 4078194390
effective search space used: 4078194390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.