Search of human proteins with 4557541

Search of human proteins with 4557541

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557541 torsin A [Homo sapiens]
         (332 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557541 torsin A [Homo sapiens]                                    674   0.0  
gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens]       467   e-132
gi|145386578 torsin family 2, member A isoform a [Homo sapiens]       275   4e-74
gi|115647957 torsin family 3, member A [Homo sapiens]                 248   7e-66
gi|145386549 torsin family 2, member A isoform b [Homo sapiens]       169   4e-42
gi|197313700 torsin family 2, member A isoform c [Homo sapiens]       169   4e-42
gi|116063568 hypothetical protein LOC54863 [Homo sapiens]              74   2e-13
gi|13540606 caseinolytic peptidase B [Homo sapiens]                    39   0.006
gi|109452617 chromosome 19 open reading frame 34 [Homo sapiens]        29   5.1  
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    28   8.7  
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    28   8.7  
gi|32483369 origin recognition complex, subunit 3 isoform 1 [Hom...    28   8.7  
gi|32483367 origin recognition complex, subunit 3 isoform 2 [Hom...    28   8.7  

>gi|4557541 torsin A [Homo sapiens]
          Length = 332

 Score =  674 bits (1739), Expect = 0.0
 Identities = 332/332 (100%), Positives = 332/332 (100%)

Query: 1   MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREA 60
           MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREA
Sbjct: 1   MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREA 60

Query: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
           LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY
Sbjct: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120

Query: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
           EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI
Sbjct: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180

Query: 181 DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL 240
           DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL
Sbjct: 181 DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL 240

Query: 241 SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV 300
           SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV
Sbjct: 241 SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV 300

Query: 301 AEEMTFFPKEERVFSDKGCKTVFTKLDYYYDD 332
           AEEMTFFPKEERVFSDKGCKTVFTKLDYYYDD
Sbjct: 301 AEEMTFFPKEERVFSDKGCKTVFTKLDYYYDD 332


>gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens]
          Length = 336

 Score =  467 bits (1202), Expect = e-132
 Identities = 222/329 (67%), Positives = 275/329 (83%), Gaps = 4/329 (1%)

Query: 4   GRAVLGLLLLAPSVVQAVEPISLGLAL--AGVLTGYI-YPRLYCLFAECCGQKRSLSREA 60
           G A L LLL A  VV A EPI++GLA+  A  +TGY+ Y  +YC FAECC ++R L+  A
Sbjct: 9   GAAALALLLAA-RVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREERPLNASA 67

Query: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
           L+ DL++ LFGQHLA ++I  A+ GF NN  PKKPLTLSLHGW GTGKNFVS+I+AEN++
Sbjct: 68  LKLDLEEKLFGQHLATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLH 127

Query: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
             GL S++VHLFV+TLHFPH   I LY+DQLQ WIRGNVSACA S+FIFDEMDK+H G+I
Sbjct: 128 PKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMDKLHPGII 187

Query: 181 DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL 240
           DAIKPFLDYY+ VDGVSY+KA+FIFLSNAG + IT  ALDFWR+G++REDI+LKD+E  L
Sbjct: 188 DAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQLKDLEPVL 247

Query: 241 SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV 300
           SV VFNNK+SG WHS LID+NLIDYF+PFLPLEY+H+KMC+R EM++RG  IDEDIV+RV
Sbjct: 248 SVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRV 307

Query: 301 AEEMTFFPKEERVFSDKGCKTVFTKLDYY 329
           AEEMTFFP++E+++SDKGCKTV ++LD++
Sbjct: 308 AEEMTFFPRDEKIYSDKGCKTVQSRLDFH 336


>gi|145386578 torsin family 2, member A isoform a [Homo sapiens]
          Length = 321

 Score =  275 bits (703), Expect = 4e-74
 Identities = 125/269 (46%), Positives = 191/269 (71%)

Query: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
           L+ DL  +L GQHLAK +++ A+  F+ +P P KPL LSLHGWTGTGK++VS ++A  ++
Sbjct: 52  LECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLF 111

Query: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
           +GGL S  VH F   LHFPH S+I  YK  L+ W++GN++AC RS+F+FDEMDKM  GL+
Sbjct: 112 QGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLM 171

Query: 181 DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL 240
           + ++PFL    +V G +Y+KA+FIF+SN G E+I  VAL+ WRS + RE+I L+++E  +
Sbjct: 172 EVLRPFLGSSWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEILLQELEPVI 231

Query: 241 SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV 300
           S +V +N + GF +S +++  L+D  VPFLPL+  H++ C+  E+   G E  +++V  V
Sbjct: 232 SRAVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAV 291

Query: 301 AEEMTFFPKEERVFSDKGCKTVFTKLDYY 329
            +  TFFP++E++FS  GCKTV +++ ++
Sbjct: 292 LDSTTFFPEDEQLFSSNGCKTVASRIAFF 320


>gi|115647957 torsin family 3, member A [Homo sapiens]
          Length = 397

 Score =  248 bits (632), Expect = 7e-66
 Identities = 122/315 (38%), Positives = 193/315 (61%), Gaps = 6/315 (1%)

Query: 20  AVEPISLGLALAGVLTGYIYPRLYCLFAECCGQ---KRSLSREALQKDLDDNLFGQHLAK 76
           A  P+   L L G     +    YC F +CC +   + S +   L+ DL+  L GQHL +
Sbjct: 82  ATGPLGWRLPLLGQRYLDLLTTWYCSFKDCCPRGDCRISNNFTGLEWDLNVRLHGQHLVQ 141

Query: 77  KIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIYEGGLNSDYVHLFVATL 136
           +++L  V G++  P+P+K L LS HGW+GTGKNFV++++ EN+Y  GL SD V +F+AT 
Sbjct: 142 QLVLRTVRGYLETPQPEKALALSFHGWSGTGKNFVARMLVENLYRDGLMSDCVRMFIATF 201

Query: 137 HFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDLVDGV 196
           HFPH   + LYK+QL   IR     C +++FIFDE +K+H GL++ + P L+     +G 
Sbjct: 202 HFPHPKYVDLYKEQLMSQIRETQQLCHQTLFIFDEAEKLHPGLLEVLGPHLE-RRAPEGH 260

Query: 197 SYQK--AMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWH 254
             +    +F+FLSN   + I +V L   ++G  RE+I ++ +E  L   +    ++GF H
Sbjct: 261 RAESPWTIFLFLSNLRGDIINEVVLKLLKAGWSREEITMEHLEPHLQAEIVETIDNGFGH 320

Query: 255 SSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRVAEEMTFFPKEERVF 314
           S L+  NLIDYF+PFLPLEY+H+++C R    S+     E+ +  +A+ M + PKEE++F
Sbjct: 321 SRLVKENLIDYFIPFLPLEYRHVRLCARDAFLSQELLYKEETLDEIAQMMVYVPKEEQLF 380

Query: 315 SDKGCKTVFTKLDYY 329
           S +GCK++  +++Y+
Sbjct: 381 SSQGCKSISQRINYF 395


>gi|145386549 torsin family 2, member A isoform b [Homo sapiens]
          Length = 253

 Score =  169 bits (427), Expect = 4e-42
 Identities = 76/146 (52%), Positives = 108/146 (73%)

Query: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
           L+ DL  +L GQHLAK +++ A+  F+ +P P KPL LSLHGWTGTGK++VS ++A  ++
Sbjct: 52  LECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLF 111

Query: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
           +GGL S  VH F   LHFPH S+I  YK  L+ W++GN++AC RS+F+FDEMDKM  GL+
Sbjct: 112 QGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLM 171

Query: 181 DAIKPFLDYYDLVDGVSYQKAMFIFL 206
           + ++PFL    +V G +Y+KA+FIF+
Sbjct: 172 EVLRPFLGSSWVVYGTNYRKAIFIFI 197


>gi|197313700 torsin family 2, member A isoform c [Homo sapiens]
          Length = 242

 Score =  169 bits (427), Expect = 4e-42
 Identities = 76/146 (52%), Positives = 108/146 (73%)

Query: 61  LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY 120
           L+ DL  +L GQHLAK +++ A+  F+ +P P KPL LSLHGWTGTGK++VS ++A  ++
Sbjct: 52  LECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLF 111

Query: 121 EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI 180
           +GGL S  VH F   LHFPH S+I  YK  L+ W++GN++AC RS+F+FDEMDKM  GL+
Sbjct: 112 QGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLM 171

Query: 181 DAIKPFLDYYDLVDGVSYQKAMFIFL 206
           + ++PFL    +V G +Y+KA+FIF+
Sbjct: 172 EVLRPFLGSSWVVYGTNYRKAIFIFI 197


>gi|116063568 hypothetical protein LOC54863 [Homo sapiens]
          Length = 423

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 66/279 (23%), Positives = 121/279 (43%), Gaps = 28/279 (10%)

Query: 59  EALQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAEN 118
           + L+K L   +FGQ  A   I+  +  ++      +PL L+LHG +G GK+ V +++A +
Sbjct: 151 DGLEKALQRAVFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGRLLARH 210

Query: 119 IYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARS----IFIFDEMDK 174
                 +S  V  + A  H P A      +++L   +   V+         + + D+++ 
Sbjct: 211 FRSVLEDSALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLDDVEL 270

Query: 175 MHAGLIDAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVAL-----------DFWR 223
           M   L+D +  FL          +  A+++ LS AG   +T   L           D +R
Sbjct: 271 MPRPLLDELHGFLQPQ---RSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRPDGFR 327

Query: 224 SGKQREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRV 283
           S +       +D+  +L   +  ++    W ++ I        VPFL L+ + +  C R 
Sbjct: 328 SAEAAAAQAEEDLRASLLAVL--SREHPLWQAAAI--------VPFLLLDKRDVVSCFRD 377

Query: 284 EMQSRGYEIDEDIVSRVAEEMTFFPKEERVFSDKGCKTV 322
           EM   G+  D+     +A +++F+    R F+  GCK V
Sbjct: 378 EMAGEGFFPDQARAENLAAQLSFYRVAGREFAVTGCKQV 416


>gi|13540606 caseinolytic peptidase B [Homo sapiens]
          Length = 707

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 54/252 (21%), Positives = 104/252 (41%), Gaps = 37/252 (14%)

Query: 52  QKRSLSREA-------LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKK-PLTLSLHGW 103
           Q++   REA       L++ L +++ GQ  A   +  A+    N    ++ PL     G 
Sbjct: 323 QEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGS 382

Query: 104 TGTGKNFVSKIIAENIYEGGLNSDYVHLFVATLHFPHA--------SNITLYKDQLQLWI 155
           +G GK  ++K  A+ +++      ++ L ++     H              +++  QL  
Sbjct: 383 SGIGKTELAKQTAKYMHKDA-KKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTK 441

Query: 156 RGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDLVDG----VSYQKAMFIFLSNAGA 211
           +  +  C  ++ +FDE+DK H  ++  +    D   L DG    +  + A+FI  SN  +
Sbjct: 442 K--LKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVAS 499

Query: 212 ERITDVALDFWRS----GKQREDIKLKDIEHALSVSVFNN---------KNSGFWHSSLI 258
           + I   AL   +      + R    L D++ +  +++  N           + F     +
Sbjct: 500 DEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFL 559

Query: 259 DR-NLIDYFVPF 269
            R N I YF+PF
Sbjct: 560 GRINEIVYFLPF 571


>gi|109452617 chromosome 19 open reading frame 34 [Homo sapiens]
          Length = 148

 Score = 29.3 bits (64), Expect = 5.1
 Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 5/40 (12%)

Query: 40  PRLYCLFAECCGQKRSLSREALQKDLDDNLFGQHLAKKII 79
           PRL CLF   CG +R+ SR          L G HL  +++
Sbjct: 112 PRLECLFPSSCGSRRATSRPGFPP-----LEGSHLGCQLL 146


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 28.5 bits (62), Expect = 8.7
 Identities = 14/38 (36%), Positives = 21/38 (55%), Gaps = 4/38 (10%)

Query: 227  QREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLID 264
            ++ED+ L  +EH         +NSG W S  +DRNL +
Sbjct: 1316 EQEDMGLCSLEHLPP----RTRNSGIWESPELDRNLAE 1349


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 28.5 bits (62), Expect = 8.7
 Identities = 14/38 (36%), Positives = 21/38 (55%), Gaps = 4/38 (10%)

Query: 227  QREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLID 264
            ++ED+ L  +EH         +NSG W S  +DRNL +
Sbjct: 1276 EQEDMGLCSLEHLPP----RTRNSGIWESPELDRNLAE 1309


>gi|32483369 origin recognition complex, subunit 3 isoform 1 [Homo
           sapiens]
          Length = 712

 Score = 28.5 bits (62), Expect = 8.7
 Identities = 20/75 (26%), Positives = 35/75 (46%), Gaps = 3/75 (4%)

Query: 197 SYQKAMFIFLSNAGAERITDVALDFWRSGK-QREDIKLKDIEHALSVSVFNNKNSGFWHS 255
           S  K  F+F  N+   +I+    D++  GK + ED KL+   + L      ++N      
Sbjct: 5   SMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEE 64

Query: 256 SLIDRNLIDYFVPFL 270
             +++NL D  + FL
Sbjct: 65  --LNKNLFDNLIEFL 77


>gi|32483367 origin recognition complex, subunit 3 isoform 2 [Homo
           sapiens]
          Length = 711

 Score = 28.5 bits (62), Expect = 8.7
 Identities = 20/75 (26%), Positives = 35/75 (46%), Gaps = 3/75 (4%)

Query: 197 SYQKAMFIFLSNAGAERITDVALDFWRSGK-QREDIKLKDIEHALSVSVFNNKNSGFWHS 255
           S  K  F+F  N+   +I+    D++  GK + ED KL+   + L      ++N      
Sbjct: 5   SMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEE 64

Query: 256 SLIDRNLIDYFVPFL 270
             +++NL D  + FL
Sbjct: 65  --LNKNLFDNLIEFL 77


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,653,915
Number of Sequences: 37866
Number of extensions: 487948
Number of successful extensions: 999
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 988
Number of HSP's gapped (non-prelim): 13
length of query: 332
length of database: 18,247,518
effective HSP length: 103
effective length of query: 229
effective length of database: 14,347,320
effective search space: 3285536280
effective search space used: 3285536280
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.