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Search of human proteins with 4506529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506529 rhodopsin kinase [Homo sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506529 rhodopsin kinase [Homo sapiens] 1144 0.0
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 521 e-148
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 521 e-148
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 521 e-148
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 521 e-148
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 503 e-142
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 486 e-137
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 483 e-136
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 470 e-132
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 274 2e-73
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 269 4e-72
gi|47157325 protein kinase C, delta [Homo sapiens] 218 1e-56
gi|31377782 protein kinase C, delta [Homo sapiens] 218 1e-56
gi|5453976 protein kinase C, theta [Homo sapiens] 218 2e-56
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 205 8e-53
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 204 1e-52
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 204 2e-52
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 204 2e-52
gi|4502023 AKT2 kinase [Homo sapiens] 202 7e-52
gi|40254851 protein kinase PKNbeta [Homo sapiens] 202 9e-52
gi|5453974 protein kinase N2 [Homo sapiens] 200 3e-51
gi|4506067 protein kinase C, alpha [Homo sapiens] 200 3e-51
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 199 4e-51
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 199 4e-51
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 199 4e-51
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 199 4e-51
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 198 1e-50
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 198 1e-50
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 197 3e-50
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 197 3e-50
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 1144 bits (2958), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES 60
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES
Sbjct: 1 MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES 60
Query: 61 VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK 120
VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK
Sbjct: 61 VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK 120
Query: 121 LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL 180
LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL
Sbjct: 121 LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL 180
Query: 181 EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK 240
EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK
Sbjct: 181 EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK 240
Query: 241 ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ 300
ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ
Sbjct: 241 ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ 300
Query: 301 IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA 360
IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA
Sbjct: 301 IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA 360
Query: 361 PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS 420
PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS
Sbjct: 361 PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS 420
Query: 421 QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY 480
QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY
Sbjct: 421 QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY 480
Query: 481 AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM 540
AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM
Sbjct: 481 AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM 540
Query: 541 PDDMKGISGGSSSSSKSGMCLVS 563
PDDMKGISGGSSSSSKSGMCLVS
Sbjct: 541 PDDMKGISGGSSSSSKSGMCLVS 563
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 521 bits (1342), Expect = e-148
Identities = 257/540 (47%), Positives = 374/540 (69%), Gaps = 6/540 (1%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VAN+ + AR G + + KK+ LK P +S+CE LR ++ ++ S+C +Q
Sbjct: 3 LENIVANTVLLKAREG--GGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG+ LF+QF ++ ++ + +Y+ ++ +K + I+ +YL P++ +F +
Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
Query: 126 LDEGIVAKFKEGPVEIQ-DGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQP 184
+ + +V++ +E ++ LF Q+ +L PF EYL S++F RFLQWKWLE QP
Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
Query: 185 MGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK 244
+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACK+L KKR+KKRKG A+ EK+IL K
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
Query: 245 VHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICG 304
V+S+F+V+LAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RALFY A+I+CG
Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCG 298
Query: 305 LEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELL 364
LE LH+ VYRDLKPEN+LLD+ G++RISDLGLAV++ +G +G GT G+MAPE+L
Sbjct: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEVL 357
Query: 365 QGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASK 424
+ Y S DY+ LG +YEMI + PFR R EKV+ +E+ R++ Y KFS+ +K
Sbjct: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417
Query: 425 DFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDI 484
C+ LL KD ++RLG ++E +++ HP F+++N+++LEAGML PPF+PD + VY KD+
Sbjct: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477
Query: 485 QDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDM 544
D+ FSTVKGV D TD +F+ +F+TG+ IPWQ EMIET F ELNV+ +G +P D+
Sbjct: 478 LDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDL 537
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 521 bits (1341), Expect = e-148
Identities = 262/543 (48%), Positives = 371/543 (68%), Gaps = 12/543 (2%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VAN+ + AR G ++ + KK+ L+ P +S+CE LR SL ++ S+C Q
Sbjct: 3 LENIVANTVLLKAREG--GGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG+ LF++F + + + + +Y+ +D + + + +L
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 126 LDEGIVA----KFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLE 181
+ +V + ++GP + LFQ L + T +L APF +YL S+YF RFLQWKWLE
Sbjct: 121 VPRQLVTNCTQRLEQGPCK---DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLE 177
Query: 182 AQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI 241
QP+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+I
Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237
Query: 242 LMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQI 301
L KV+SRF+VSLAYA+ETK LCLV+T+MNGGD+++HIY++ + GFPE RA+FY A+I
Sbjct: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA--GFPEARAVFYAAEI 295
Query: 302 ICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAP 361
CGLE LH+ RIVYRDLKPEN+LLD+ G++RISDLGLAV + +GQ+ KG GT G+MAP
Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAP 354
Query: 362 ELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQ 421
E+++ E Y FS D++ALG LYEMIA + PF+ R +K++ +E++ + P +Y ++FS
Sbjct: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414
Query: 422 ASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYA 481
++ C LL KDP +RLG R + +++ HPLFK LN+++L AGML PPF PD + +Y
Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474
Query: 482 KDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMP 541
KD+ D+ FSTVKGV + TD +F+Q+FATG+ PIPWQ EM+ET F ELNV+ DG +P
Sbjct: 475 KDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVP 534
Query: 542 DDM 544
D+
Sbjct: 535 PDL 537
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 521 bits (1341), Expect = e-148
Identities = 262/543 (48%), Positives = 371/543 (68%), Gaps = 12/543 (2%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VAN+ + AR G ++ + KK+ L+ P +S+CE LR SL ++ S+C Q
Sbjct: 3 LENIVANTVLLKAREG--GGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG+ LF++F + + + + +Y+ +D + + + +L
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 126 LDEGIVA----KFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLE 181
+ +V + ++GP + LFQ L + T +L APF +YL S+YF RFLQWKWLE
Sbjct: 121 VPRQLVTNCTQRLEQGPCK---DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLE 177
Query: 182 AQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI 241
QP+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+I
Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237
Query: 242 LMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQI 301
L KV+SRF+VSLAYA+ETK LCLV+T+MNGGD+++HIY++ + GFPE RA+FY A+I
Sbjct: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA--GFPEARAVFYAAEI 295
Query: 302 ICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAP 361
CGLE LH+ RIVYRDLKPEN+LLD+ G++RISDLGLAV + +GQ+ KG GT G+MAP
Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAP 354
Query: 362 ELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQ 421
E+++ E Y FS D++ALG LYEMIA + PF+ R +K++ +E++ + P +Y ++FS
Sbjct: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414
Query: 422 ASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYA 481
++ C LL KDP +RLG R + +++ HPLFK LN+++L AGML PPF PD + +Y
Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474
Query: 482 KDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMP 541
KD+ D+ FSTVKGV + TD +F+Q+FATG+ PIPWQ EM+ET F ELNV+ DG +P
Sbjct: 475 KDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVP 534
Query: 542 DDM 544
D+
Sbjct: 535 PDL 537
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 521 bits (1341), Expect = e-148
Identities = 262/543 (48%), Positives = 371/543 (68%), Gaps = 12/543 (2%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VAN+ + AR G ++ + KK+ L+ P +S+CE LR SL ++ S+C Q
Sbjct: 3 LENIVANTVLLKAREG--GGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG+ LF++F + + + + +Y+ +D + + + +L
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 126 LDEGIVA----KFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLE 181
+ +V + ++GP + LFQ L + T +L APF +YL S+YF RFLQWKWLE
Sbjct: 121 VPRQLVTNCTQRLEQGPCK---DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLE 177
Query: 182 AQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI 241
QP+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+I
Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237
Query: 242 LMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQI 301
L KV+SRF+VSLAYA+ETK LCLV+T+MNGGD+++HIY++ + GFPE RA+FY A+I
Sbjct: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA--GFPEARAVFYAAEI 295
Query: 302 ICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAP 361
CGLE LH+ RIVYRDLKPEN+LLD+ G++RISDLGLAV + +GQ+ KG GT G+MAP
Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAP 354
Query: 362 ELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQ 421
E+++ E Y FS D++ALG LYEMIA + PF+ R +K++ +E++ + P +Y ++FS
Sbjct: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414
Query: 422 ASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYA 481
++ C LL KDP +RLG R + +++ HPLFK LN+++L AGML PPF PD + +Y
Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474
Query: 482 KDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMP 541
KD+ D+ FSTVKGV + TD +F+Q+FATG+ PIPWQ EM+ET F ELNV+ DG +P
Sbjct: 475 KDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVP 534
Query: 542 DDM 544
D+
Sbjct: 535 PDL 537
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 503 bits (1296), Expect = e-142
Identities = 259/541 (47%), Positives = 358/541 (66%), Gaps = 7/541 (1%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VANS + AR G S R KK+ L LPP+S+C LR S+ ++ S+C +Q
Sbjct: 3 LENIVANSLLLKARQGGYGKKS--GRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG++LF+QF + +E + +Y+ AD++ + +IL ++ + +
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 126 LDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQ 183
+ +V + + G E F+ + +L PF+EY S YF +FLQWKWLE Q
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 184 PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILM 243
P+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+IL
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 244 KVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIIC 303
KV SRF+VSLAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RA+FY A++ C
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCC 298
Query: 304 GLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPEL 363
GLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G GT G+MAPE+
Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEV 357
Query: 364 LQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQAS 423
+ E+Y FS D++ LG +YEMI PF+ EKV+ +E+ RI ++ +Y +KFS+ +
Sbjct: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
Query: 424 KDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKD 483
K C LL K+P KRLG R E ++ HP+FKD+N+R+LEA ML PPF PD VY KD
Sbjct: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKD 477
Query: 484 IQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDD 543
+ D+ FS VKG+ D D +F+ FATG IPWQ EMIE+G F ++N S+ +P D
Sbjct: 478 VLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLD 537
Query: 544 M 544
+
Sbjct: 538 L 538
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 486 bits (1252), Expect = e-137
Identities = 253/530 (47%), Positives = 347/530 (65%), Gaps = 7/530 (1%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE +VANS + AR G S R KK+ L LPP+S+C LR S+ ++ S+C +Q
Sbjct: 3 LENIVANSLLLKARQGGYGKKS--GRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
PIG++LF+QF + +E + +Y+ AD++ + +IL ++ + +
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 126 LDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQ 183
+ +V + + G E F+ + +L PF+EY S YF +FLQWKWLE Q
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 184 PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILM 243
P+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+IL
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 244 KVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIIC 303
KV SRF+VSLAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RA+FY A++ C
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCC 298
Query: 304 GLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPEL 363
GLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G GT G+MAPE+
Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEV 357
Query: 364 LQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQAS 423
+ E+Y FS D++ LG +YEMI PF+ EKV+ +E+ RI ++ +Y +KFS+ +
Sbjct: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
Query: 424 KDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKD 483
K C LL K+P KRLG R E ++ HP+FKD+N+R+LEA ML PPF PD VY KD
Sbjct: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKD 477
Query: 484 IQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNV 533
+ D+ FS VKG+ D D +F+ FATG IPWQ E T + E V
Sbjct: 478 VLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEV 527
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 483 bits (1242), Expect = e-136
Identities = 270/572 (47%), Positives = 374/572 (65%), Gaps = 31/572 (5%)
Query: 1 MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES 60
+D G+L+ ++AN+A++ AR D S + R ++ LA LP L C LR LSL F S
Sbjct: 2 VDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLA---LPGLQGCAELRQKLSLNFHS 58
Query: 61 VCLEQPIGKKLFQQFL------QSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQY 114
+C +QPIG++LF+ FL + A L ++ W+ E+ T D+ LQ A A
Sbjct: 59 LCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPA 118
Query: 115 L-DPQAKLFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQA-TLAHLGQAPFQEYLGSLYFL 172
+PQ FL + + K + E + L +A +A L + PF++++ S ++
Sbjct: 119 PGNPQP-----FLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYD 173
Query: 173 RFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGY 232
+FLQWK E QP+ + +F +FRVLGKGGFGEV A Q+K TGK+YACKKL+KKRLKK+ G
Sbjct: 174 KFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGE 233
Query: 233 QGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEP 292
+ A++EK+IL KV S FIVSLAYAFE+K LCLVM++MNGGD+++HIYNV G
Sbjct: 234 KMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR--GLDMS 291
Query: 293 RALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGY 352
R +FY+AQI CG+ HLH+ IVYRD+KPENVLLD+ GN R+SDLGLAVE+ G+ T+
Sbjct: 292 RVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQ-R 350
Query: 353 AGTPGFMAPELLQGE-EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISE 411
AGT G+MAPE+L + Y + VD+FA+G ++YEM+A R PF+ EKV ++LK R + +
Sbjct: 351 AGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQD 410
Query: 412 PVKYP-DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMP 470
VK+ D F++ +KD C L K PE+RLG R+++ D R H FK +N+ +LEAG++ P
Sbjct: 411 EVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRLEAGLIEP 469
Query: 471 PFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGE 530
PF+PD VYAKDI ++ FS V+GV FD D +FF+ FATG PI WQEE+IETG+F E
Sbjct: 470 PFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEE 529
Query: 531 LNVWRSDGQMPDDMKGISGGSSSSSKSGMCLV 562
LN P+ G G +SSKSG+CL+
Sbjct: 530 LN-------DPNRPTGCEEG--NSSKSGVCLL 552
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 470 bits (1209), Expect = e-132
Identities = 237/490 (48%), Positives = 330/490 (67%), Gaps = 5/490 (1%)
Query: 57 EFESVCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLD 116
++ S+C +QPIG++LF+QF + +E + +Y+ AD++ + +IL ++ +
Sbjct: 20 DYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFN 79
Query: 117 PQAKLFCSFLDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRF 174
+ + +V + + G E F+ + +L PF+EY S YF +F
Sbjct: 80 DKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQF 139
Query: 175 LQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQG 234
LQWKWLE QP+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG
Sbjct: 140 LQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAM 199
Query: 235 AMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRA 294
A+ EK+IL KV SRF+VSLAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RA
Sbjct: 200 ALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRA 257
Query: 295 LFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAG 354
+FY A++ CGLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G G
Sbjct: 258 VFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVG 316
Query: 355 TPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVK 414
T G+MAPE++ E+Y FS D++ LG +YEMI PF+ EKV+ +E+ RI ++ +
Sbjct: 317 TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE 376
Query: 415 YPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
Y +KFS+ +K C LL K+P KRLG R E ++ HP+FKD+N+R+LEA ML PPF P
Sbjct: 377 YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
Query: 475 DSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVW 534
D VY KD+ D+ FS VKG+ D D +F+ FATG IPWQ EMIE+G F ++N
Sbjct: 437 DPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKS 496
Query: 535 RSDGQMPDDM 544
S+ +P D+
Sbjct: 497 ESEEALPLDL 506
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 274 bits (700), Expect = 2e-73
Identities = 180/539 (33%), Positives = 289/539 (53%), Gaps = 24/539 (4%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
LE V+A+ +++ A + + + K L + + + + + L D + FE + Q
Sbjct: 4 LEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQ-KYLEDRGEVTFEKI-FSQ 61
Query: 66 PIGKKLFQQF-LQSAEKHLPALELWKDIEDYDTADNDLQP-QKAQTILAQYLDPQAKLFC 123
+G LF+ F L E+ P +E +++I+ Y+ + + + +++ I Y+ + L C
Sbjct: 62 KLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKEL-LAC 120
Query: 124 SFLDEGIVAKFKEGPV---EIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL 180
S + +G + ++ LFQP ++ +L FQ+++ S F RF QWK +
Sbjct: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
Query: 181 EAQ-PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEK 239
E + + F R++G+GGFGEV C+ TGK+YA K L+KKR+K ++G A+ E+
Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 240 KILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALF 296
+L V + FIV ++YAF T L ++ +MNGGD+ YH+ ++ F E F
Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----SQHGVFSEADMRF 296
Query: 297 YTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTP 356
Y A+II GLEH+H R +VYRDLKP N+LLD G+VRISDLGLA + + K GT
Sbjct: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTH 354
Query: 357 GFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKY 415
G+MAPE+LQ G YD S D+F+LG L++++ PFR K + E+ ++ V+
Sbjct: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVEL 413
Query: 416 PDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
PD FS + E LL++D +RLG +++ P F+ L+W+ + PP IP
Sbjct: 414 PDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473
Query: 476 SKTVYAKDIQDVGAF--STVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELN 532
V A D D+G+F KG+ +D E ++ F WQ+E+ ET +F +N
Sbjct: 474 RGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 530
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 269 bits (688), Expect = 4e-72
Identities = 181/536 (33%), Positives = 280/536 (52%), Gaps = 31/536 (5%)
Query: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKC--ESLRDSLSLEFESVCL 63
LE V+A+ +++ A + S + P+ L P + + L + + F+ +
Sbjct: 4 LEAVLADVSYLMA---MEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKI-F 59
Query: 64 EQPIGKKLFQQF-LQSAEKHLPALELWKDIEDYDTADNDLQPQ-KAQTILAQYLDPQAKL 121
Q IG LF+ F L + +P ++ +++I++Y+ DN+ +++ I Y+ + L
Sbjct: 60 NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKEL-L 118
Query: 122 FCSFLDEGIVAKFKEGPV---EIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWK 178
CS + + + ++ LFQP ++ L FQ+++ S F RF QWK
Sbjct: 119 SCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWK 178
Query: 179 WLEAQ---PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGA 235
+E M E F R++G+GGFGEV C+ TGK+YA K L+KKR+K ++G A
Sbjct: 179 NVELNIHLTMNE--FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236
Query: 236 MVEKKILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEP 292
+ E+ +L V + FIV + YAF T LC ++ +MNGGD+ YH+ ++ F E
Sbjct: 237 LNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGVFSEK 292
Query: 293 RALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGY 352
FY +II GLEH+H R +VYRDLKP N+LLD G+ RISDLGLA + + K
Sbjct: 293 EMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHAS 350
Query: 353 AGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISE 411
GT G+MAPE+LQ G YD S D+F+LG L++++ PFR K + E+ ++
Sbjct: 351 VGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTV 409
Query: 412 PVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPP 471
V+ PD FS K E LL++D KRLG +++ H FK ++W+ + PP
Sbjct: 410 NVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPP 469
Query: 472 FIPDSKTVYAKDIQDVGAF--STVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIET 525
IP V A D D+G+F KG+ D E ++ F WQ+E+ ET
Sbjct: 470 LIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 218 bits (555), Expect = 1e-56
Identities = 119/290 (41%), Positives = 171/290 (58%), Gaps = 13/290 (4%)
Query: 190 FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKIL-MKVHSR 248
F+ +VLGKG FG+V ++K G+ +A K L K + + MVEK++L + +
Sbjct: 349 FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP 408
Query: 249 FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHL 308
F+ L F+TK L VM +NGGD+ YHI ++ F RA FY A+I+CGL+ L
Sbjct: 409 FLTHLICTFQTKDHLFFVMEFLNGGDLMYHI----QDKGRFELYRATFYAAEIMCGLQFL 464
Query: 309 HQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEE 368
H + I+YRDLK +NVLLD DG+++I+D G+ E + G+S+ + GTP ++APE+LQG +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 369 YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCE 428
Y FSVD+++ GV LYEM+ + PF E EL I + YP ++ SKD E
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 429 ALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKT 478
L E++P KRLG ++ HP FK +NW LE L PPF P K+
Sbjct: 581 KLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKS 626
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 218 bits (555), Expect = 1e-56
Identities = 119/290 (41%), Positives = 171/290 (58%), Gaps = 13/290 (4%)
Query: 190 FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKIL-MKVHSR 248
F+ +VLGKG FG+V ++K G+ +A K L K + + MVEK++L + +
Sbjct: 349 FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP 408
Query: 249 FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHL 308
F+ L F+TK L VM +NGGD+ YHI ++ F RA FY A+I+CGL+ L
Sbjct: 409 FLTHLICTFQTKDHLFFVMEFLNGGDLMYHI----QDKGRFELYRATFYAAEIMCGLQFL 464
Query: 309 HQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEE 368
H + I+YRDLK +NVLLD DG+++I+D G+ E + G+S+ + GTP ++APE+LQG +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 369 YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCE 428
Y FSVD+++ GV LYEM+ + PF E EL I + YP ++ SKD E
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 429 ALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKT 478
L E++P KRLG ++ HP FK +NW LE L PPF P K+
Sbjct: 581 KLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKS 626
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 218 bits (554), Expect = 2e-56
Identities = 116/292 (39%), Positives = 176/292 (60%), Gaps = 13/292 (4%)
Query: 190 FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR- 248
F+ ++LGKG FG+V + K T + +A K L K + + MVEK++L
Sbjct: 380 FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 439
Query: 249 FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHL 308
F+ + F+TK +L VM +NGGD+ YHI + ++ F RA FY A+II GL+ L
Sbjct: 440 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK----FDLSRATFYAAEIILGLQFL 495
Query: 309 HQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEE 368
H + IVYRDLK +N+LLD DG+++I+D G+ E + G +KT + GTP ++APE+L G++
Sbjct: 496 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQK 555
Query: 369 YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCE 428
Y+ SVD+++ GV LYEM+ + PF + E +EL H I + YP + +KD
Sbjct: 556 YNHSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLV 611
Query: 429 ALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY 480
L ++PEKRLG R + +R HPLF+++NW +LE + PPF P K+ +
Sbjct: 612 KLFVREPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRPKVKSPF 659
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 205 bits (522), Expect = 8e-53
Identities = 116/342 (33%), Positives = 179/342 (52%), Gaps = 29/342 (8%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSL 253
++LGKG FG+V + KA+GK YA K L K+ + + + E ++L F+ SL
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSL 211
Query: 254 AYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRI 313
Y+F+TK LC VM +NGG++ +H+ F E R FY A+I+ L++LH +I
Sbjct: 212 KYSFQTKDRLCFVMEYVNGGELFFHL----SRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 314 VYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSV 373
VYRDLK EN++LD DG+++I+D GL E + + K + GTP ++APE+L+ +Y +V
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 374 DYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEK 433
D++ LGV +YEM+ R PF + ++++L I+ E +K+P S +K LL K
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383
Query: 434 DPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTV 493
DP KRLG + ++ H F +NW+ + L+PPF P
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ------------------ 425
Query: 494 KGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWR 535
+TDT +F E T E + G L W+
Sbjct: 426 ---VTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWK 464
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 204 bits (520), Expect = 1e-52
Identities = 106/281 (37%), Positives = 165/281 (58%), Gaps = 8/281 (2%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSL 253
++LGKG FG+V + KA+GK YA K L K+ + + + E ++L F+ SL
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSL 211
Query: 254 AYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRI 313
Y+F+TK LC VM +NGG++ +H+ F E R FY A+I+ L++LH +I
Sbjct: 212 KYSFQTKDRLCFVMEYVNGGELFFHL----SRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 314 VYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSV 373
VYRDLK EN++LD DG+++I+D GL E + + K + GTP ++APE+L+ +Y +V
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 374 DYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEK 433
D++ LGV +YEM+ R PF + ++++L I+ E +K+P S +K LL K
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIK 383
Query: 434 DPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
DP KRLG + ++ H F +NW+ + L+PPF P
Sbjct: 384 DPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 204 bits (519), Expect = 2e-52
Identities = 122/339 (35%), Positives = 180/339 (53%), Gaps = 33/339 (9%)
Query: 180 LEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEK 239
L P+ + F VLG+G FG+V + + +G+L+A K L K + R + M EK
Sbjct: 611 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 670
Query: 240 KILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALF 296
+IL V S F+V+L F+T +C VM GGD+ HI++ F EPRA+F
Sbjct: 671 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-----DVFSEPRAIF 725
Query: 297 YTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTP 356
Y+A ++ GL+ LH+ +IVYRDLK +N+LLD +G V+I+D GL E + +T + GTP
Sbjct: 726 YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP 785
Query: 357 GFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYP 416
F+APE+L Y +VD++ LGV LYEM+ PF E +E+ I+++ V+YP
Sbjct: 786 EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYP 841
Query: 417 DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDS 476
S + LL ++PE+RLG + + ++ P F+ L W L A L PPF+P
Sbjct: 842 RFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP-- 899
Query: 477 KTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCP 515
T+ G +TD F E TG P
Sbjct: 900 ---------------TLSG----RTDVSNFDEEFTGEAP 919
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 204 bits (519), Expect = 2e-52
Identities = 122/339 (35%), Positives = 180/339 (53%), Gaps = 33/339 (9%)
Query: 180 LEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEK 239
L P+ + F VLG+G FG+V + + +G+L+A K L K + R + M EK
Sbjct: 605 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 664
Query: 240 KILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALF 296
+IL V S F+V+L F+T +C VM GGD+ HI++ F EPRA+F
Sbjct: 665 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-----DVFSEPRAIF 719
Query: 297 YTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTP 356
Y+A ++ GL+ LH+ +IVYRDLK +N+LLD +G V+I+D GL E + +T + GTP
Sbjct: 720 YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP 779
Query: 357 GFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYP 416
F+APE+L Y +VD++ LGV LYEM+ PF E +E+ I+++ V+YP
Sbjct: 780 EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYP 835
Query: 417 DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDS 476
S + LL ++PE+RLG + + ++ P F+ L W L A L PPF+P
Sbjct: 836 RFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP-- 893
Query: 477 KTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCP 515
T+ G +TD F E TG P
Sbjct: 894 ---------------TLSG----RTDVSNFDEEFTGEAP 913
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 202 bits (514), Expect = 7e-52
Identities = 104/281 (37%), Positives = 164/281 (58%), Gaps = 8/281 (2%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSL 253
++LGKG FG+V + KATG+ YA K L K+ + + + E ++L F+ +L
Sbjct: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
Query: 254 AYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRI 313
YAF+T LC VM NGG++ +H+ F E RA FY A+I+ LE+LH R +
Sbjct: 216 KYAFQTHDRLCFVMEYANGGELFFHL----SRERVFTEERARFYGAEIVSALEYLHSRDV 271
Query: 314 VYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSV 373
VYRD+K EN++LD DG+++I+D GL E + + K + GTP ++APE+L+ +Y +V
Sbjct: 272 VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV 331
Query: 374 DYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEK 433
D++ LGV +YEM+ R PF + +++ L I+ E +++P S +K LL+K
Sbjct: 332 DWWGLGVVMYEMMCGRLPFYNQ----DHERLFELILMEEIRFPRTLSPEAKSLLAGLLKK 387
Query: 434 DPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
DP++RLG ++ H F +NW+ + L+PPF P
Sbjct: 388 DPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 202 bits (513), Expect = 9e-52
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 15/289 (5%)
Query: 192 DFR---VLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR 248
DFR VLG+G FG+V Q K TGK YA K L K+ + R + EK+IL V
Sbjct: 558 DFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCT 617
Query: 249 ---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGL 305
F++SL F+T + C V + GGD+ I+ FPEP+A FY A ++ GL
Sbjct: 618 GHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-----DVFPEPQARFYVACVVLGL 672
Query: 306 EHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ 365
+ LH+++I+YRDLK +N+LLD G ++I+D GL E + +T + GTP F+APE+L
Sbjct: 673 QFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLT 732
Query: 366 GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKD 425
E Y +VD++ LGV LYEM+ PF E +E+ I++ YP S +
Sbjct: 733 QEAYTRAVDWWGLGVLLYEMLVGECPFPGDTE----EEVFDCIVNMDAPYPGFLSVQGLE 788
Query: 426 FCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
F + LL+K PEKRLG ++ ++++ P F+ NW+ L A + PPF+P
Sbjct: 789 FIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVP 837
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 200 bits (509), Expect = 3e-51
Identities = 111/289 (38%), Positives = 167/289 (57%), Gaps = 15/289 (5%)
Query: 192 DFR---VLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHS- 247
DFR VLG+G FG+V + K T +++A K L K + R M EK+I V+S
Sbjct: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
Query: 248 --RFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGL 305
F+V+L F+TK +C VM GGD+ HI+ F EPRA+FY A ++ GL
Sbjct: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-----DVFSEPRAVFYAACVVLGL 770
Query: 306 EHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ 365
++LH+ +IVYRDLK +N+LLD +G V+I+D GL E + +T + GTP F+APE+L
Sbjct: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830
Query: 366 GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKD 425
Y +VD++ LGV +YEM+ PF E +E+ I+++ V+YP S +
Sbjct: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAIS 886
Query: 426 FCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
LL ++PE+RLG ++ + ++ HP F+ ++W L + PPFIP
Sbjct: 887 IMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 935
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 200 bits (508), Expect = 3e-51
Identities = 114/282 (40%), Positives = 166/282 (58%), Gaps = 11/282 (3%)
Query: 195 VLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR-FIVSL 253
VLGKG FG+V K T +LYA K L K + + + MVEK++L + F+ L
Sbjct: 344 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 403
Query: 254 AYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRI 313
F+T L VM +NGGD+ YHI V + F EP+A+FY A+I GL LH+R I
Sbjct: 404 HSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK----FKEPQAVFYAAEISIGLFFLHKRGI 459
Query: 314 VYRDLKPENVLLDNDGNVRISDLGLAVE-LLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
+YRDLK +NV+LD++G+++I+D G+ E ++DG + T+ + GTP ++APE++ + Y S
Sbjct: 460 IYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT-TRTFCGTPDYIAPEIIAYQPYGKS 518
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++A GV LYEM+A + PF E EL I+ V YP S+ + C+ L+
Sbjct: 519 VDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLSKEAVSICKGLMT 574
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
K P KRLG E +R H F+ ++W +LE + PPF P
Sbjct: 575 KHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 199 bits (507), Expect = 4e-51
Identities = 108/283 (38%), Positives = 168/283 (59%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + KA YA K L KK + K+K + M E+ +L+K V F+V
Sbjct: 102 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 161
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L ++F+T L V+ +NGG++ YH+ + F EPRA FY A+I L +LH
Sbjct: 162 LHFSFQTADKLYFVLDYINGGELFYHL----QRERCFLEPRARFYAAEIASALGYLHSLN 217
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G++ ++D GL E ++ S T + GTP ++APE+L + YD +
Sbjct: 218 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT 277
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF +R E+ I+++P++ + +++ E LL+
Sbjct: 278 VDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 333
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD KRLG +D+ + +++H F +NW L + PPF P+
Sbjct: 334 KDRTKRLGAKDDFME-IKSHVFFSLINWDDLINKKITPPFNPN 375
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 199 bits (507), Expect = 4e-51
Identities = 108/283 (38%), Positives = 168/283 (59%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + KA YA K L KK + K+K + M E+ +L+K V F+V
Sbjct: 116 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 175
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L ++F+T L V+ +NGG++ YH+ + F EPRA FY A+I L +LH
Sbjct: 176 LHFSFQTADKLYFVLDYINGGELFYHL----QRERCFLEPRARFYAAEIASALGYLHSLN 231
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G++ ++D GL E ++ S T + GTP ++APE+L + YD +
Sbjct: 232 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT 291
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF +R E+ I+++P++ + +++ E LL+
Sbjct: 292 VDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 347
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD KRLG +D+ + +++H F +NW L + PPF P+
Sbjct: 348 KDRTKRLGAKDDFME-IKSHVFFSLINWDDLINKKITPPFNPN 389
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 199 bits (507), Expect = 4e-51
Identities = 108/283 (38%), Positives = 168/283 (59%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + KA YA K L KK + K+K + M E+ +L+K V F+V
Sbjct: 130 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 189
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L ++F+T L V+ +NGG++ YH+ + F EPRA FY A+I L +LH
Sbjct: 190 LHFSFQTADKLYFVLDYINGGELFYHL----QRERCFLEPRARFYAAEIASALGYLHSLN 245
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G++ ++D GL E ++ S T + GTP ++APE+L + YD +
Sbjct: 246 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT 305
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF +R E+ I+++P++ + +++ E LL+
Sbjct: 306 VDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 361
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD KRLG +D+ + +++H F +NW L + PPF P+
Sbjct: 362 KDRTKRLGAKDDFME-IKSHVFFSLINWDDLINKKITPPFNPN 403
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 199 bits (507), Expect = 4e-51
Identities = 108/283 (38%), Positives = 168/283 (59%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + KA YA K L KK + K+K + M E+ +L+K V F+V
Sbjct: 197 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 256
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L ++F+T L V+ +NGG++ YH+ + F EPRA FY A+I L +LH
Sbjct: 257 LHFSFQTADKLYFVLDYINGGELFYHL----QRERCFLEPRARFYAAEIASALGYLHSLN 312
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G++ ++D GL E ++ S T + GTP ++APE+L + YD +
Sbjct: 313 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT 372
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF +R E+ I+++P++ + +++ E LL+
Sbjct: 373 VDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 428
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD KRLG +D+ + +++H F +NW L + PPF P+
Sbjct: 429 KDRTKRLGAKDDFME-IKSHVFFSLINWDDLINKKITPPFNPN 470
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 198 bits (503), Expect = 1e-50
Identities = 108/296 (36%), Positives = 172/296 (58%), Gaps = 11/296 (3%)
Query: 182 AQPMGEDWFLDF-RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK 240
A P + DF +V+GKG +G+V + K+ G YA K L KK + K+K M E+
Sbjct: 26 ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 85
Query: 241 ILMK-VHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTA 299
+L+K V F+V L Y+F+T L V+ +NGG++ +H+ + F EPRA FY A
Sbjct: 86 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHL----QRERRFLEPRARFYAA 141
Query: 300 QIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFM 359
++ + +LH I+YRDLKPEN+LLD G+V ++D GL E ++ + T + GTP ++
Sbjct: 142 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 201
Query: 360 APELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKF 419
APE+L+ E YD +VD++ LG LYEM+ PF ++ + ++ I+ +P++ P
Sbjct: 202 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQ----DVSQMYENILHQPLQIPGGR 257
Query: 420 SQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
+ A+ D ++LL KD +RLG + + + ++ H F +NW L L PPF P+
Sbjct: 258 TVAACDLLQSLLHKDQRQRLGSKADFLE-IKNHVFFSPINWDDLYHKRLTPPFNPN 312
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 198 bits (503), Expect = 1e-50
Identities = 108/296 (36%), Positives = 172/296 (58%), Gaps = 11/296 (3%)
Query: 182 AQPMGEDWFLDF-RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK 240
A P + DF +V+GKG +G+V + K+ G YA K L KK + K+K M E+
Sbjct: 86 ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 145
Query: 241 ILMK-VHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTA 299
+L+K V F+V L Y+F+T L V+ +NGG++ +H+ + F EPRA FY A
Sbjct: 146 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHL----QRERRFLEPRARFYAA 201
Query: 300 QIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFM 359
++ + +LH I+YRDLKPEN+LLD G+V ++D GL E ++ + T + GTP ++
Sbjct: 202 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 261
Query: 360 APELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKF 419
APE+L+ E YD +VD++ LG LYEM+ PF ++ + ++ I+ +P++ P
Sbjct: 262 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQ----DVSQMYENILHQPLQIPGGR 317
Query: 420 SQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
+ A+ D ++LL KD +RLG + + + ++ H F +NW L L PPF P+
Sbjct: 318 TVAACDLLQSLLHKDQRQRLGSKADFLE-IKNHVFFSPINWDDLYHKRLTPPFNPN 372
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 197 bits (500), Expect = 3e-50
Identities = 109/283 (38%), Positives = 165/283 (58%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + K GK YA K L KK + RK + M E+ +L+K V F+V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L Y+F+T L V+ +NGG++ +H+ + FPE RA FY A+I L +LH +
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHL----QRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G+V ++D GL E + T + GTP ++APE+++ + YD +
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF R + E+ I+ +P+ S + E LLE
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCR----DVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 397
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD + RLG +++ + ++ HP F+ L+W L + PPF P+
Sbjct: 398 KDRQNRLGAKEDFLE-IQNHPFFESLSWADLVQKKIPPPFNPN 439
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 197 bits (500), Expect = 3e-50
Identities = 109/283 (38%), Positives = 165/283 (58%), Gaps = 10/283 (3%)
Query: 194 RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK-VHSRFIVS 252
+V+GKG FG+V + K GK YA K L KK + RK + M E+ +L+K V F+V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 253 LAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRR 312
L Y+F+T L V+ +NGG++ +H+ + FPE RA FY A+I L +LH +
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHL----QRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 313 IVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFS 372
IVYRDLKPEN+LLD+ G+V ++D GL E + T + GTP ++APE+++ + YD +
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 373 VDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLE 432
VD++ LG LYEM+ PF R + E+ I+ +P+ S + E LLE
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCR----DVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 397
Query: 433 KDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
KD + RLG +++ + ++ HP F+ L+W L + PPF P+
Sbjct: 398 KDRQNRLGAKEDFLE-IQNHPFFESLSWADLVQKKIPPPFNPN 439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,943,830
Number of Sequences: 37866
Number of extensions: 1004873
Number of successful extensions: 4321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 693
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 2207
Number of HSP's gapped (non-prelim): 949
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.