Search of human proteins with 4506321

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506321 protein tyrosine phosphatase, receptor type, N
precursor [Homo sapiens]
         (979 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506321 protein tyrosine phosphatase, receptor type, N precur...  1967   0.0  
gi|194097440 protein tyrosine phosphatase, receptor type, N poly...   710   0.0  
gi|194097438 protein tyrosine phosphatase, receptor type, N poly...   690   0.0  
gi|194097442 protein tyrosine phosphatase, receptor type, N poly...   682   0.0  
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   180   5e-45
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   180   7e-45
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   179   1e-44
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   179   1e-44
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   179   1e-44
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   179   1e-44
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   179   1e-44
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   178   3e-44
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   177   4e-44
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   177   4e-44
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   177   4e-44
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   177   6e-44
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   177   6e-44
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   177   6e-44
gi|148728162 protein tyrosine phosphatase, receptor type, J isof...   174   5e-43
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   174   5e-43
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   174   5e-43
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   173   6e-43
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   173   6e-43
gi|196114951 protein tyrosine phosphatase, non-receptor type 12 ...   172   2e-42
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   170   5e-42
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   170   5e-42
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   170   7e-42
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   167   6e-41
gi|224586931 protein tyrosine phosphatase, non-receptor type 22 ...   165   2e-40
gi|224586929 protein tyrosine phosphatase, non-receptor type 22 ...   165   2e-40

>gi|4506321 protein tyrosine phosphatase, receptor type, N precursor
           [Homo sapiens]
          Length = 979

 Score = 1967 bits (5096), Expect = 0.0
 Identities = 979/979 (100%), Positives = 979/979 (100%)

Query: 1   MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFG 60
           MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFG
Sbjct: 1   MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFG 60

Query: 61  QCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPE 120
           QCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPE
Sbjct: 61  QCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPE 120

Query: 121 PRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAEL 180
           PRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAEL
Sbjct: 121 PRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAEL 180

Query: 181 LPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEA 240
           LPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEA
Sbjct: 181 LPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEA 240

Query: 241 PALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG 300
           PALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG
Sbjct: 241 PALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG 300

Query: 301 SSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTL 360
           SSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTL
Sbjct: 301 SSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTL 360

Query: 361 LTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSE 420
           LTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSE
Sbjct: 361 LTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSE 420

Query: 421 VQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKP 480
           VQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKP
Sbjct: 421 VQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKP 480

Query: 481 LSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSE 540
           LSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSE
Sbjct: 481 LSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSE 540

Query: 541 LEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCV 600
           LEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCV
Sbjct: 541 LEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCV 600

Query: 601 RQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQ 660
           RQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQ
Sbjct: 601 RQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQ 660

Query: 661 FSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQ 720
           FSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQ
Sbjct: 661 FSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQ 720

Query: 721 AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAY 780
           AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAY
Sbjct: 721 AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAY 780

Query: 781 IATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLV 840
           IATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLV
Sbjct: 781 IATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLV 840

Query: 841 SEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG 900
           SEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG
Sbjct: 841 SEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG 900

Query: 901 RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE 960
           RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE
Sbjct: 901 RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE 960

Query: 961 FALTAVAEEVNAILKALPQ 979
           FALTAVAEEVNAILKALPQ
Sbjct: 961 FALTAVAEEVNAILKALPQ 979


>gi|194097440 protein tyrosine phosphatase, receptor type, N
            polypeptide 2 isoform 1 precursor [Homo sapiens]
          Length = 1015

 Score =  710 bits (1833), Expect = 0.0
 Identities = 460/1047 (43%), Positives = 584/1047 (55%), Gaps = 119/1047 (11%)

Query: 16   LRLLLCLLLL----------SSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVG 65
            L LLL LLLL          SS P G       GCL +  LC   E C+ DG+FG+CQ  
Sbjct: 5    LPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKV 64

Query: 66   VGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPR--LRPPEP-- 121
                    +V+   LQRL+  L++L   G +W DD TQYV+ QE+  +P+  LR PE   
Sbjct: 65   PAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASS 124

Query: 122  --RPRDRSGLAPKRPGPAGELLLQDI--------------PTGSAPAAQHRLPQPPVGKG 165
              RP   S  + +R    G   L +               P     A  H     P  +G
Sbjct: 125  PARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEG 184

Query: 166  GAGASSSL-----------------SPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQP 208
                S S+                 + L+ +LLP  L  L    QP   S   +  + + 
Sbjct: 185  DDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQL----QPDELSPKVDSGVDRH 240

Query: 209  YLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPS 268
            +L     +    R     PG  S+ P     AP+   R               GD   PS
Sbjct: 241  HLMAALSAYAAQR-PPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPS 299

Query: 269  ------------------PAQLFQDSGL-LYLAQELPAPSRARVPRLPEQGSSSRAEDSP 309
                              PA++   SGL L    EL A     V     +GS  RA    
Sbjct: 300  STGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGE 359

Query: 310  EGYEKEGLGD--RGEKPASPAVQPD-----AALQRLAAVLAGYGVELRQLTPEQLSTLLT 362
             G + +G     RG+      VQ D       + RL+A L G                  
Sbjct: 360  SGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGG------------------ 401

Query: 363  LLQLLPKGAGRNPGGVVNVGADI---KKTMEGPVEGRDTAELPARTSPMPGHPTASPTSS 419
               LL     R   G +     +   +K  E P     + E    T+ +    + + +  
Sbjct: 402  ---LLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEE---ETAGVENVKSQTYSKD 455

Query: 420  EVQQVPSPVSSEPPKAARPPVT-----PVLLEKKSPLGQSQPTVAG-QPSARPAAEEY-G 472
             + Q P    SEP  AA   +      P   E+  P G  +    G Q   +P+ EE  G
Sbjct: 456  LLGQQPH---SEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARG 512

Query: 473  YIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQ 532
            YIVTD+ PL    G +L+E +A  + + S +F ++ V+GPA+TF++  N QN++  DV +
Sbjct: 513  YIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEK 572

Query: 533  QAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLV 592
                 K +LE  +GL+ILQTGVG + +   + PQ     S  + + LTLV+LA + G+L+
Sbjct: 573  ATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDST-KFIALTLVSLACILGVLL 631

Query: 593  ALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPS 652
            A  +  C+R  ++ + KE+L+ LG +    D T  YQ+LCRQ MAT+   +R EGP   S
Sbjct: 632  ASGLIYCLRHSSQHRLKEKLSGLGGDPG-ADATAAYQELCRQRMATRPP-DRPEGP-HTS 688

Query: 653  RVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKE 712
            R+SSVSSQFSD    SPS+ SS  SW EEP Q+NMDISTGHMIL+YMEDHL+N++RL KE
Sbjct: 689  RISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKE 748

Query: 713  WQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE 772
            W+ALCAYQAEPN+   AQ E N+ KNR    L YDH+R+ LK E+S S SDYINASPI++
Sbjct: 749  WEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMD 808

Query: 773  HDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLY 832
            HDPR PAYIATQGPL  T+ADFWQMVWESGC VIVMLTPL E+GV+QC  YWPDEG++LY
Sbjct: 809  HDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLY 868

Query: 833  HVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRR 892
            H+YEVNLVSEHIWCEDFLVRSFYLKN+QT ETRT+TQFHFLSW   G P+S+R LLDFRR
Sbjct: 869  HIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRR 928

Query: 893  KVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGL 952
            KVNKCYRGRSCPIIVHCSDGAGR+GTY+LIDMVLN+MAKG KEIDIAATLEH+RDQRPG+
Sbjct: 929  KVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGM 988

Query: 953  VRSKDQFEFALTAVAEEVNAILKALPQ 979
            V++K+QFEFALTAVAEEVNAILKALPQ
Sbjct: 989  VQTKEQFEFALTAVAEEVNAILKALPQ 1015


>gi|194097438 protein tyrosine phosphatase, receptor type, N
           polypeptide 2 isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  690 bits (1780), Expect = 0.0
 Identities = 455/1037 (43%), Positives = 579/1037 (55%), Gaps = 121/1037 (11%)

Query: 18  LLLCLLLLSSR--PGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQV 75
           LLL LLLL  R  P   S+V        R+L   L     DG+FG+CQ          +V
Sbjct: 8   LLLLLLLLPPRVLPAAPSSVPR-----GRQLPGRL-----DGVFGRCQKVPAMDFYRYEV 57

Query: 76  TSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPR--LRPPEP----RPRDRSGL 129
           +   LQRL+  L++L   G +W DD TQYV+ QE+  +P+  LR PE     RP   S  
Sbjct: 58  SPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVG 117

Query: 130 APKRPGPAGELLLQDI--------------PTGSAPAAQHRLPQPPVGKGGAGASSSL-- 173
           + +R    G   L +               P     A  H     P  +G    S S+  
Sbjct: 118 SERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILT 177

Query: 174 ---------------SPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRD 218
                          + L+ +LLP  L  L    QP   S   +  + + +L     +  
Sbjct: 178 YVAHTSALTYPPGSRTQLREDLLPRTLGQL----QPDELSPKVDSGVDRHHLMAALSAYA 233

Query: 219 GSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPS---------- 268
             R     PG  S+ P     AP+   R               GD   PS          
Sbjct: 234 AQR-PPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHT 292

Query: 269 --------PAQLFQDSGL-LYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGD 319
                   PA++   SGL L    EL A     V     +GS  RA     G + +G   
Sbjct: 293 LLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKA 352

Query: 320 --RGEKPASPAVQPD-----AALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAG 372
             RG+      VQ D       + RL+A L G                     LL     
Sbjct: 353 TLRGDSFPDDGVQDDDDRLYQEVHRLSATLGG---------------------LLQDHGS 391

Query: 373 RNPGGVVNVGADI---KKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVS 429
           R   G +     +   +K  E P     + E    T+ +    + + +   + Q P    
Sbjct: 392 RLLPGALPFARPLDMERKKSEHPESSLSSEE---ETAGVENVKSQTYSKDLLGQQPH--- 445

Query: 430 SEPPKAARPPVT-----PVLLEKKSPLGQSQPTVAG-QPSARPAAEEY-GYIVTDQKPLS 482
           SEP  AA   +      P   E+  P G  +    G Q   +P+ EE  GYIVTD+ PL 
Sbjct: 446 SEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLR 505

Query: 483 LAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELE 542
              G +L+E +A  + + S +F ++ V+GPA+TF++  N QN++  DV +     K +LE
Sbjct: 506 PEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLE 565

Query: 543 AQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQ 602
             +GL+ILQTGVG + +   + PQ     S  + + LTLV+LA + G+L+A  +  C+R 
Sbjct: 566 ETSGLKILQTGVGSKSKLKFLPPQAEQEDST-KFIALTLVSLACILGVLLASGLIYCLRH 624

Query: 603 HARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFS 662
            ++ + KE+L+ LG +    D T  YQ+LCRQ MAT+   +R EGP   SR+SSVSSQFS
Sbjct: 625 SSQHRLKEKLSGLGGDPG-ADATAAYQELCRQRMATRPP-DRPEGP-HTSRISSVSSQFS 681

Query: 663 DAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAE 722
           D    SPS+ SS  SW EEP Q+NMDISTGHMIL+YMEDHL+N++RL KEW+ALCAYQAE
Sbjct: 682 DGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAE 741

Query: 723 PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIA 782
           PN+   AQ E N+ KNR    L YDH+R+ LK E+S S SDYINASPI++HDPR PAYIA
Sbjct: 742 PNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIA 801

Query: 783 TQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSE 842
           TQGPL  T+ADFWQMVWESGC VIVMLTPL E+GV+QC  YWPDEG++LYH+YEVNLVSE
Sbjct: 802 TQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSE 861

Query: 843 HIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRS 902
           HIWCEDFLVRSFYLKN+QT ETRT+TQFHFLSW   G P+S+R LLDFRRKVNKCYRGRS
Sbjct: 862 HIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS 921

Query: 903 CPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFA 962
           CPIIVHCSDGAGR+GTY+LIDMVLN+MAKG KEIDIAATLEH+RDQRPG+V++K+QFEFA
Sbjct: 922 CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFA 981

Query: 963 LTAVAEEVNAILKALPQ 979
           LTAVAEEVNAILKALPQ
Sbjct: 982 LTAVAEEVNAILKALPQ 998


>gi|194097442 protein tyrosine phosphatase, receptor type, N
           polypeptide 2 isoform 3 precursor [Homo sapiens]
          Length = 986

 Score =  682 bits (1761), Expect = 0.0
 Identities = 452/1047 (43%), Positives = 569/1047 (54%), Gaps = 148/1047 (14%)

Query: 16  LRLLLCLLLL----------SSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVG 65
           L LLL LLLL          SS P G       GCL +  LC   E C+ DG+FG+CQ  
Sbjct: 5   LPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKV 64

Query: 66  VGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPR--LRPPEP-- 121
                   +V+   LQRL+  L++L   G +W DD TQYV+ QE+  +P+  LR PE   
Sbjct: 65  PAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASS 124

Query: 122 --RPRDRSGLAPKRPGPAGELLLQDI--------------PTGSAPAAQHRLPQPPVGKG 165
             RP   S  + +R    G   L +               P     A  H     P  +G
Sbjct: 125 PARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEG 184

Query: 166 GAGASSSL-----------------SPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQP 208
               S S+                 + L+ +LLP  L  L    QP   S   +  + + 
Sbjct: 185 DDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQL----QPDELSPKVDSGVDRH 240

Query: 209 YLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPS 268
           +L     +    R     PG  S+ P     AP+   R               GD   PS
Sbjct: 241 HLMAALSAYAAQR-PPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPS 299

Query: 269 ------------------PAQLFQDSGL-LYLAQELPAPSRARVPRLPEQGSSSRAEDSP 309
                             PA++   SGL L    EL A     V     +GS  RA    
Sbjct: 300 STGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGE 359

Query: 310 EGYEKEGLGD--RGEKPASPAVQPD-----AALQRLAAVLAGYGVELRQLTPEQLSTLLT 362
            G + +G     RG+      VQ D       + RL+A L G                  
Sbjct: 360 SGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGG------------------ 401

Query: 363 LLQLLPKGAGRNPGGVVNVGADI---KKTMEGPVEGRDTAELPARTSPMPGHPTASPTSS 419
              LL     R   G +     +   +K  E P     + E    T+ +    + + +  
Sbjct: 402 ---LLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEE---ETAGVENVKSQTYSKD 455

Query: 420 EVQQVPSPVSSEPPKAARPPVT-----PVLLEKKSPLGQSQPTVAG-QPSARPAAEEY-G 472
            + Q P    SEP  AA   +      P   E+  P G  +    G Q   +P+ EE  G
Sbjct: 456 LLGQQPH---SEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARG 512

Query: 473 YIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQ 532
           YIVTD++                             V+GPA+TF++  N QN++  DV +
Sbjct: 513 YIVTDRE-----------------------------VLGPAVTFKVSANVQNVTTEDVEK 543

Query: 533 QAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLV 592
                K +LE  +GL+ILQTGVG + +   + PQ     S  + + LTLV+LA + G+L+
Sbjct: 544 ATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDST-KFIALTLVSLACILGVLL 602

Query: 593 ALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPS 652
           A  +  C+R  ++ + KE+L+ LG +    D T  YQ+LCRQ MAT+   +R EGP   S
Sbjct: 603 ASGLIYCLRHSSQHRLKEKLSGLGGDPG-ADATAAYQELCRQRMATRPP-DRPEGP-HTS 659

Query: 653 RVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKE 712
           R+SSVSSQFSD    SPS+ SS  SW EEP Q+NMDISTGHMIL+YMEDHL+N++RL KE
Sbjct: 660 RISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKE 719

Query: 713 WQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE 772
           W+ALCAYQAEPN+   AQ E N+ KNR    L YDH+R+ LK E+S S SDYINASPI++
Sbjct: 720 WEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMD 779

Query: 773 HDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLY 832
           HDPR PAYIATQGPL  T+ADFWQMVWESGC VIVMLTPL E+GV+QC  YWPDEG++LY
Sbjct: 780 HDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLY 839

Query: 833 HVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRR 892
           H+YEVNLVSEHIWCEDFLVRSFYLKN+QT ETRT+TQFHFLSW   G P+S+R LLDFRR
Sbjct: 840 HIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRR 899

Query: 893 KVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGL 952
           KVNKCYRGRSCPIIVHCSDGAGR+GTY+LIDMVLN+MAKG KEIDIAATLEH+RDQRPG+
Sbjct: 900 KVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGM 959

Query: 953 VRSKDQFEFALTAVAEEVNAILKALPQ 979
           V++K+QFEFALTAVAEEVNAILKALPQ
Sbjct: 960 VQTKEQFEFALTAVAEEVNAILKALPQ 986


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  180 bits (457), Expect = 5e-45
 Identities = 141/476 (29%), Positives = 225/476 (47%), Gaps = 53/476 (11%)

Query: 520  HNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLL 579
            + E  ++   +  +A +  +++   T L +L TG            Q +++  P + V  
Sbjct: 712  NGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGAST---------QNSNTVEPEKQVDN 762

Query: 580  TLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATK 639
            T+     +AGLL+ + + L V    +++             +  +   Y  L ++   T+
Sbjct: 763  TVKMAGVIAGLLMFIIILLGVMLTIKRR------------RNAYSYSYYLKLAKKQKETQ 810

Query: 640  SLFNRAEGP----PEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDIST---- 691
            S   R  GP     +P+   S S      + +S   +  T     E +Q  + I T    
Sbjct: 811  SGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYR 870

Query: 692  --GHMILAYMEDHLRNRDRLAKEWQALCA------------YQAEPN----TCATAQGEG 733
                + ++Y  D  +   R+A   Q +              Y+A P     +  TA+ + 
Sbjct: 871  TCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDE 930

Query: 734  NIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE-HDPRMPAYIATQGPLSHTIA 792
            N  KNR+ + + YDH+R++L V      SDYINA+ I   H PR   YIATQGP+  T+ 
Sbjct: 931  NRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRH--YIATQGPMQETVK 988

Query: 793  DFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVR 852
            DFW+M+W+     IVM+T LVE G  +C RYWPD+   +Y   +V L+      E +++R
Sbjct: 989  DFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAE-YVIR 1046

Query: 853  SFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDG 912
            +F ++     E R L  FHF SWP  G P     LL F R+V       + PI+VHCS G
Sbjct: 1047 TFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAG 1106

Query: 913  AGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
            AGRTG +I ID +L+ MA+    +DI   +  +R QR  LV++++Q+ F   A+ E
Sbjct: 1107 AGRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1161



 Score =  122 bits (307), Expect = 1e-27
 Identities = 84/280 (30%), Positives = 140/280 (50%), Gaps = 14/280 (5%)

Query: 701  DHLRNRDRLAKEWQAL--CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS 758
            D   N  ++  E+Q L     +  P  C+      N  KNR  D LP D   +   +   
Sbjct: 1186 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRC-LPFLISVD 1244

Query: 759  PSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK 818
               S+YINA+ +  H  +  A++ TQ PL +T+ADFW++V++  C+ +VML  +  D  +
Sbjct: 1245 GESSNYINAALMDSHK-QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQ 1301

Query: 819  QCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQET--RTLTQFHFLSWP 876
             C +YWP++ +  Y   +V  VS  I  ED + R F + N+   +   R +    ++ WP
Sbjct: 1302 FCMQYWPEKTSGCYGPIQVEFVSADI-DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1360

Query: 877  A-EGTPASTRPLLDFRRKVNKC---YRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG 932
            A   TP S R LL   R++ K    Y GR    +VHC +G GR+GT+  I  V   M + 
Sbjct: 1361 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVC-EMIQQ 1419

Query: 933  VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA 972
               ID+   ++ +R+ +  +V + +Q++F      E +++
Sbjct: 1420 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  180 bits (456), Expect = 7e-45
 Identities = 120/339 (35%), Positives = 177/339 (52%), Gaps = 16/339 (4%)

Query: 638  TKSLFNRAE----GPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGH 693
            TK L N A+     P +P  +  ++ Q  D+   SP      P +  E   ++  I    
Sbjct: 1321 TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLRE---PGFHFESMLSHPPIPIAD 1377

Query: 694  MILAYMEDHLRNRD--RLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARI 751
            M  A   + L+  D  +L++E++++   Q    T   +  E N  KNR+ + + YDH+R+
Sbjct: 1378 M--AEHTERLKANDSLKLSQEYESIDPGQQF--TWEHSNLEVNKPKNRYANVIAYDHSRV 1433

Query: 752  KLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTP 811
             L+       SDYINA+  ++      AYIATQGPL  T  DFW+MVWE     IVM+T 
Sbjct: 1434 ILQPIEGIMGSDYINAN-YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492

Query: 812  LVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFH 871
            L E    +CD+YWP+ G   Y   +V L+ + I    F VR+F L    + E R + QF 
Sbjct: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQ 1551

Query: 872  FLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAK 931
            F +WP  G P    P L F R+V  C    + PI+VHCS G GRTG +I+ID +L R+ K
Sbjct: 1552 FTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI-K 1610

Query: 932  GVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
              K +D+   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1611 PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649



 Score =  177 bits (448), Expect = 6e-44
 Identities = 99/260 (38%), Positives = 156/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L   +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1683 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1741

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE+  T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1742 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR 1801

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1802 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1860

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1861 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1918

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++D+++F   A  E
Sbjct: 1919 RPAMVQTEDEYQFCYQAALE 1938


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  179 bits (453), Expect = 1e-44
 Identities = 100/260 (38%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1237 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1295

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE   T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1296 DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1355

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1356 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1414

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1415 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1472

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++F+  A  E
Sbjct: 1473 RPAMVQTEDQYQFSYRAALE 1492



 Score =  168 bits (426), Expect = 2e-41
 Identities = 92/239 (38%), Positives = 135/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDY+NA+  I+   +  AYIATQG L  T 
Sbjct: 968  EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN-YIDGYRKQNAYIATQGSLPETF 1026

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+M+WE     +VM+T L E    +CD+YWP  G   + + +V L+ + +    + V
Sbjct: 1027 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCV 1085

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + P++VHCS 
Sbjct: 1086 RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSA 1145

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +DI   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1146 GVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  179 bits (453), Expect = 1e-44
 Identities = 100/260 (38%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1647 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1705

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE   T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1706 DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1765

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1766 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1824

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1825 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1882

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++F+  A  E
Sbjct: 1883 RPAMVQTEDQYQFSYRAALE 1902



 Score =  168 bits (426), Expect = 2e-41
 Identities = 92/239 (38%), Positives = 135/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDY+NA+  I+   +  AYIATQG L  T 
Sbjct: 1378 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN-YIDGYRKQNAYIATQGSLPETF 1436

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+M+WE     +VM+T L E    +CD+YWP  G   + + +V L+ + +    + V
Sbjct: 1437 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCV 1495

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + P++VHCS 
Sbjct: 1496 RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSA 1555

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +DI   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1556 GVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  179 bits (453), Expect = 1e-44
 Identities = 100/260 (38%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1634 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1692

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE   T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1693 DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1752

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1753 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1811

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1812 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1869

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++F+  A  E
Sbjct: 1870 RPAMVQTEDQYQFSYRAALE 1889



 Score =  168 bits (426), Expect = 2e-41
 Identities = 92/239 (38%), Positives = 135/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDY+NA+  I+   +  AYIATQG L  T 
Sbjct: 1365 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN-YIDGYRKQNAYIATQGSLPETF 1423

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+M+WE     +VM+T L E    +CD+YWP  G   + + +V L+ + +    + V
Sbjct: 1424 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCV 1482

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + P++VHCS 
Sbjct: 1483 RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSA 1542

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +DI   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1543 GVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  179 bits (453), Expect = 1e-44
 Identities = 100/260 (38%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1638 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1696

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE   T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1697 DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1756

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1757 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1815

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1816 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1873

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++F+  A  E
Sbjct: 1874 RPAMVQTEDQYQFSYRAALE 1893



 Score =  168 bits (426), Expect = 2e-41
 Identities = 92/239 (38%), Positives = 135/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDY+NA+  I+   +  AYIATQG L  T 
Sbjct: 1369 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN-YIDGYRKQNAYIATQGSLPETF 1427

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+M+WE     +VM+T L E    +CD+YWP  G   + + +V L+ + +    + V
Sbjct: 1428 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCV 1486

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + P++VHCS 
Sbjct: 1487 RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSA 1546

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +DI   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1547 GVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  179 bits (453), Expect = 1e-44
 Identities = 100/260 (38%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1236 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1294

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE   T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1295 DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1354

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1355 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1413

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1414 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1471

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++F+  A  E
Sbjct: 1472 RPAMVQTEDQYQFSYRAALE 1491



 Score =  168 bits (426), Expect = 2e-41
 Identities = 92/239 (38%), Positives = 135/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDY+NA+  I+   +  AYIATQG L  T 
Sbjct: 967  EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN-YIDGYRKQNAYIATQGSLPETF 1025

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+M+WE     +VM+T L E    +CD+YWP  G   + + +V L+ + +    + V
Sbjct: 1026 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL-DTVELATYCV 1084

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + P++VHCS 
Sbjct: 1085 RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSA 1144

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +DI   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1145 GVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  178 bits (451), Expect = 3e-44
 Identities = 134/430 (31%), Positives = 208/430 (48%), Gaps = 44/430 (10%)

Query: 566  QTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTT 625
            Q +++  P + V  T+     +AGLL+ + + L V    +++             +  + 
Sbjct: 730  QNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRR------------RNAYSY 777

Query: 626  FEYQDLCRQHMATKSLFNRAEGP----PEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEE 681
              Y  L ++   T+S   R  GP     +P+   S S      + +S   +  T     E
Sbjct: 778  SYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGE 837

Query: 682  PAQANMDIST------GHMILAYMEDHLRNRDRLAKEWQALCA------------YQAEP 723
             +Q  + I T        + ++Y  D  +   R+A   Q +              Y+A P
Sbjct: 838  LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALP 897

Query: 724  N----TCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE-HDPRMP 778
                 +  TA+ + N  KNR+ + + YDH+R++L V      SDYINA+ I   H PR  
Sbjct: 898  EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRH- 956

Query: 779  AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVN 838
             YIATQGP+  T+ DFW+M+W+     IVM+T LVE G  +C RYWPD+   +Y   +V 
Sbjct: 957  -YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVT 1014

Query: 839  LVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCY 898
            L+      E +++R+F ++     E R L  FHF SWP  G P     LL F R+V    
Sbjct: 1015 LIETEPLAE-YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLN 1073

Query: 899  RGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQ 958
               + PI+VHCS GAGRTG +I ID +L+ MA+    +DI   +  +R QR  LV++++Q
Sbjct: 1074 PPEAGPIVVHCSAGAGRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132

Query: 959  FEFALTAVAE 968
            + F   A+ E
Sbjct: 1133 YVFVHDAILE 1142



 Score =  122 bits (307), Expect = 1e-27
 Identities = 84/280 (30%), Positives = 140/280 (50%), Gaps = 14/280 (5%)

Query: 701  DHLRNRDRLAKEWQAL--CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS 758
            D   N  ++  E+Q L     +  P  C+      N  KNR  D LP D   +   +   
Sbjct: 1167 DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRC-LPFLISVD 1225

Query: 759  PSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK 818
               S+YINA+ +  H  +  A++ TQ PL +T+ADFW++V++  C+ +VML  +  D  +
Sbjct: 1226 GESSNYINAALMDSHK-QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQ 1282

Query: 819  QCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQET--RTLTQFHFLSWP 876
             C +YWP++ +  Y   +V  VS  I  ED + R F + N+   +   R +    ++ WP
Sbjct: 1283 FCMQYWPEKTSGCYGPIQVEFVSADI-DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1341

Query: 877  A-EGTPASTRPLLDFRRKVNKC---YRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG 932
            A   TP S R LL   R++ K    Y GR    +VHC +G GR+GT+  I  V   M + 
Sbjct: 1342 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVC-EMIQQ 1400

Query: 933  VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA 972
               ID+   ++ +R+ +  +V + +Q++F      E +++
Sbjct: 1401 QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
           2 precursor [Homo sapiens]
          Length = 793

 Score =  177 bits (449), Expect = 4e-44
 Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 6/266 (2%)

Query: 709 LAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           L +E++ L + + + +   T     N+KKNR    +PY+  R+ + V+     +DY+NAS
Sbjct: 524 LEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNAS 583

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
             I+   +  +YIA+QGPL HTI DFW+M+WE     IVMLT L E G ++C +YWP +G
Sbjct: 584 -FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDG 642

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLL 888
              Y    V L  E   CE + VR   + N +  ++R + QFHF  WP  G P+  + ++
Sbjct: 643 LVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 701

Query: 889 DFRRKVNK-CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM-AKGVKEIDIAATLEHVR 946
                V K   +  + PI VHCS GAGRTGT+  +  VL R+ A+G+  +D+  T++ +R
Sbjct: 702 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI--LDVFQTVKSLR 759

Query: 947 DQRPGLVRSKDQFEFALTAVAEEVNA 972
            QRP +V++ +Q+EF    V E ++A
Sbjct: 760 LQRPHMVQTLEQYEFCYKVVQEYIDA 785



 Score =  169 bits (427), Expect = 2e-41
 Identities = 101/264 (38%), Positives = 146/264 (55%), Gaps = 12/264 (4%)

Query: 711 KEWQAL--CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           +E+ AL  C  QA   TC  A  E N +KNR+ + LPYDH+R+ L        SDYINAS
Sbjct: 234 EEFNALPACPIQA---TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 290

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
            I  +  +   +IA QGP   T+ DFW+M+WE     IVM+T L E    +C +YWPD+G
Sbjct: 291 FINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 349

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNV----QTQETRTLTQFHFLSWPAEGTPAST 884
              Y    V+ V +     D+ VR F ++ V      +  R +TQFHF SWP  G P + 
Sbjct: 350 CWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTP 408

Query: 885 RPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEH 944
             +L F +KV  C    +  I+VHCS G GRTGT+++ID +L+ M    +++D+   +  
Sbjct: 409 IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSR 467

Query: 945 VRDQRPGLVRSKDQFEFALTAVAE 968
           +R QR  +V++  Q+ F   A+ E
Sbjct: 468 IRAQRCQMVQTDMQYVFIYQALLE 491


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
           precursor [Homo sapiens]
          Length = 802

 Score =  177 bits (449), Expect = 4e-44
 Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 6/266 (2%)

Query: 709 LAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           L +E++ L + + + +   T     N+KKNR    +PY+  R+ + V+     +DY+NAS
Sbjct: 533 LEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNAS 592

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
             I+   +  +YIA+QGPL HTI DFW+M+WE     IVMLT L E G ++C +YWP +G
Sbjct: 593 -FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDG 651

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLL 888
              Y    V L  E   CE + VR   + N +  ++R + QFHF  WP  G P+  + ++
Sbjct: 652 LVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 710

Query: 889 DFRRKVNK-CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM-AKGVKEIDIAATLEHVR 946
                V K   +  + PI VHCS GAGRTGT+  +  VL R+ A+G+  +D+  T++ +R
Sbjct: 711 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI--LDVFQTVKSLR 768

Query: 947 DQRPGLVRSKDQFEFALTAVAEEVNA 972
            QRP +V++ +Q+EF    V E ++A
Sbjct: 769 LQRPHMVQTLEQYEFCYKVVQEYIDA 794



 Score =  169 bits (427), Expect = 2e-41
 Identities = 101/264 (38%), Positives = 146/264 (55%), Gaps = 12/264 (4%)

Query: 711 KEWQAL--CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           +E+ AL  C  QA   TC  A  E N +KNR+ + LPYDH+R+ L        SDYINAS
Sbjct: 243 EEFNALPACPIQA---TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 299

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
            I  +  +   +IA QGP   T+ DFW+M+WE     IVM+T L E    +C +YWPD+G
Sbjct: 300 FINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 358

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNV----QTQETRTLTQFHFLSWPAEGTPAST 884
              Y    V+ V +     D+ VR F ++ V      +  R +TQFHF SWP  G P + 
Sbjct: 359 CWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTP 417

Query: 885 RPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEH 944
             +L F +KV  C    +  I+VHCS G GRTGT+++ID +L+ M    +++D+   +  
Sbjct: 418 IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSR 476

Query: 945 VRDQRPGLVRSKDQFEFALTAVAE 968
           +R QR  +V++  Q+ F   A+ E
Sbjct: 477 IRAQRCQMVQTDMQYVFIYQALLE 500


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
           2 precursor [Homo sapiens]
          Length = 793

 Score =  177 bits (449), Expect = 4e-44
 Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 6/266 (2%)

Query: 709 LAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           L +E++ L + + + +   T     N+KKNR    +PY+  R+ + V+     +DY+NAS
Sbjct: 524 LEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNAS 583

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
             I+   +  +YIA+QGPL HTI DFW+M+WE     IVMLT L E G ++C +YWP +G
Sbjct: 584 -FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDG 642

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLL 888
              Y    V L  E   CE + VR   + N +  ++R + QFHF  WP  G P+  + ++
Sbjct: 643 LVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 701

Query: 889 DFRRKVNK-CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM-AKGVKEIDIAATLEHVR 946
                V K   +  + PI VHCS GAGRTGT+  +  VL R+ A+G+  +D+  T++ +R
Sbjct: 702 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI--LDVFQTVKSLR 759

Query: 947 DQRPGLVRSKDQFEFALTAVAEEVNA 972
            QRP +V++ +Q+EF    V E ++A
Sbjct: 760 LQRPHMVQTLEQYEFCYKVVQEYIDA 785



 Score =  169 bits (427), Expect = 2e-41
 Identities = 101/264 (38%), Positives = 146/264 (55%), Gaps = 12/264 (4%)

Query: 711 KEWQAL--CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS 768
           +E+ AL  C  QA   TC  A  E N +KNR+ + LPYDH+R+ L        SDYINAS
Sbjct: 234 EEFNALPACPIQA---TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 290

Query: 769 PIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828
            I  +  +   +IA QGP   T+ DFW+M+WE     IVM+T L E    +C +YWPD+G
Sbjct: 291 FINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 349

Query: 829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNV----QTQETRTLTQFHFLSWPAEGTPAST 884
              Y    V+ V +     D+ VR F ++ V      +  R +TQFHF SWP  G P + 
Sbjct: 350 CWTYGNIRVS-VEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTP 408

Query: 885 RPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEH 944
             +L F +KV  C    +  I+VHCS G GRTGT+++ID +L+ M    +++D+   +  
Sbjct: 409 IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSR 467

Query: 945 VRDQRPGLVRSKDQFEFALTAVAE 968
           +R QR  +V++  Q+ F   A+ E
Sbjct: 468 IRAQRCQMVQTDMQYVFIYQALLE 491


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  177 bits (448), Expect = 6e-44
 Identities = 99/260 (38%), Positives = 156/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L   +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1240 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1298

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE+  T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1299 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR 1358

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1359 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1417

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1418 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1475

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++D+++F   A  E
Sbjct: 1476 RPAMVQTEDEYQFCYQAALE 1495



 Score =  175 bits (443), Expect = 2e-43
 Identities = 98/239 (41%), Positives = 136/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L+       SDYINA+  ++      AYIATQGPL  T 
Sbjct: 971  EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN-YVDGYRCQNAYIATQGPLPETF 1029

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+MVWE     IVM+T L E    +CD+YWP+ G   Y   +V L+ + I    F V
Sbjct: 1030 GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCV 1088

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + PI+VHCS 
Sbjct: 1089 RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSA 1148

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +D+   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1149 GVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  177 bits (448), Expect = 6e-44
 Identities = 99/260 (38%), Positives = 156/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L   +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1645 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1703

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE+  T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1704 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR 1763

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1764 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1822

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1823 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1880

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++D+++F   A  E
Sbjct: 1881 RPAMVQTEDEYQFCYQAALE 1900



 Score =  175 bits (443), Expect = 2e-43
 Identities = 98/239 (41%), Positives = 136/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L+       SDYINA+  ++      AYIATQGPL  T 
Sbjct: 1376 EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN-YVDGYRCQNAYIATQGPLPETF 1434

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+MVWE     IVM+T L E    +CD+YWP+ G   Y   +V L+ + I    F V
Sbjct: 1435 GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCV 1493

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + PI+VHCS 
Sbjct: 1494 RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSA 1553

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +D+   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1554 GVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  177 bits (448), Expect = 6e-44
 Identities = 99/260 (38%), Positives = 156/260 (60%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L   +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  I
Sbjct: 1236 EFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAS-FI 1294

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ T  DFW+M+WE+  T++VMLT L E G ++C +YWP E ++ 
Sbjct: 1295 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR 1354

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P S    +DF 
Sbjct: 1355 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1413

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +DI  T++ +R Q
Sbjct: 1414 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQ 1471

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++D+++F   A  E
Sbjct: 1472 RPAMVQTEDEYQFCYQAALE 1491



 Score =  175 bits (443), Expect = 2e-43
 Identities = 98/239 (41%), Positives = 136/239 (56%), Gaps = 3/239 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L+       SDYINA+  ++      AYIATQGPL  T 
Sbjct: 967  EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAN-YVDGYRCQNAYIATQGPLPETF 1025

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+MVWE     IVM+T L E    +CD+YWP+ G   Y   +V L+ + I    F V
Sbjct: 1026 GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCV 1084

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R + QF F +WP  G P    P L F R+V  C    + PI+VHCS 
Sbjct: 1085 RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSA 1144

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            G GRTG +I+ID +L R+ K  K +D+   +  +R QR  +V+++DQ+ F   A+ E V
Sbjct: 1145 GVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202


>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
            precursor [Homo sapiens]
          Length = 1337

 Score =  174 bits (440), Expect = 5e-43
 Identities = 97/241 (40%), Positives = 144/241 (59%), Gaps = 6/241 (2%)

Query: 734  NIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIAD 793
            N  KNR+ + LPYD +R+KL V++  S  DYINA+ +  +  +   +IATQGPL +T+ D
Sbjct: 1065 NRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKD-FIATQGPLPNTLKD 1122

Query: 794  FWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRS 853
            FW+MVWE     I+MLT  VE G  +C+ YWP + A  Y    V + SE I   ++ +R 
Sbjct: 1123 FWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSE-IVLPEWTIRD 1181

Query: 854  FYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGR--SCPIIVHCSD 911
            F +KN+QT E+  L QFHF SWP  G P +T  L++FR  V    +      PI+VHCS 
Sbjct: 1182 FTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSA 1241

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN 971
            G GRTGT+I ID ++ ++ +    +D+   +  +R  RP +V+++DQ+ F    V + V 
Sbjct: 1242 GVGRTGTFIAIDRLIYQI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR 1300

Query: 972  A 972
            +
Sbjct: 1301 S 1301


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  174 bits (440), Expect = 5e-43
 Identities = 100/278 (35%), Positives = 155/278 (55%), Gaps = 21/278 (7%)

Query: 711  KEWQALCAYQAEPNTCATAQG--------EGNIKKNRHPDFLPYDHARIKLK--VESSPS 760
            +E++ L  +  E  +C    G          N  KNR+ + + YDH+R+KL    E    
Sbjct: 1719 EEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGK 1778

Query: 761  RSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQC 820
             +DYINA+ +  ++ R  AYIA QGPL  T  DFW+M+WE    VIVM+T LVE G ++C
Sbjct: 1779 LTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKC 1837

Query: 821  DRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQE--------TRTLTQFHF 872
            D+YWP +G+  Y  + V   S  +    + VR+F L+N + ++         R +TQ+H+
Sbjct: 1838 DQYWPADGSEEYGNFLVTQKSVQVLAY-YTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHY 1896

Query: 873  LSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG 932
              WP  G P  + P+L F RK     R    P++VHCS G GRTGTYI++D +L ++ + 
Sbjct: 1897 TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI-QH 1955

Query: 933  VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
               ++I   L+H+R QR  LV++++Q+ F    + E +
Sbjct: 1956 EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 68/274 (24%), Positives = 128/274 (46%), Gaps = 17/274 (6%)

Query: 706  RDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYI 765
            + +L K++Q L     + +  + A  + N +KNR    +P + +R+ +   S    +DYI
Sbjct: 2020 KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYI 2078

Query: 766  NASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDR--- 822
            NAS I+ +  +   +I TQ PL HTI DFW+M+W+    ++VM    + DG    +    
Sbjct: 2079 NASYIMGYY-QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM----IPDGQNMAEDEFV 2133

Query: 823  YWPDEGASL-YHVYEVNLVSEHIWC----EDFLVRSFYLKNVQTQETRTLTQFHFLSWPA 877
            YWP++   +    ++V L++E   C    E  +++ F L+  Q      +  F    WP 
Sbjct: 2134 YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN 2193

Query: 878  EGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEID 937
              +P S     +    + +    R  P+IVH   G    GT+  +  +++++ K    +D
Sbjct: 2194 PDSPIS--KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEK-ENSVD 2250

Query: 938  IAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN 971
            +    + +   RPG+    +Q++F    +   V+
Sbjct: 2251 VYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS 2284


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  174 bits (440), Expect = 5e-43
 Identities = 101/285 (35%), Positives = 158/285 (55%), Gaps = 17/285 (5%)

Query: 700  EDHLRNRDRLAKEWQALCAYQAEPN-TCATAQGEGNIKKNRHPDFLPYDHARIKLKV--E 756
            E +  N+   +++++ +    A+ N T   +    N  KNR+ + L YDH+R+KL+    
Sbjct: 839  ELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPG 898

Query: 757  SSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDG 816
                 SDYINA+ +  ++ +  AYIATQGPL  T  DFW+M+WE    +IVM+T LVE G
Sbjct: 899  KDSKHSDYINANYVDGYN-KAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKG 957

Query: 817  VKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQT-----------QETR 865
             ++CD+YWP E +  Y    V L S  I    + VR F ++N +            Q  R
Sbjct: 958  RRKCDQYWPTENSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVKKGQKGNPKGRQNER 1016

Query: 866  TLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMV 925
             + Q+H+  WP  G P    P+L F R+ +      + P++VHCS G GRTGTYI+ID +
Sbjct: 1017 VVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSM 1076

Query: 926  LNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 970
            L ++ K    +++   L+H+R QR  LV++++Q+ F   A+ E +
Sbjct: 1077 LQQI-KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120



 Score =  102 bits (255), Expect = 1e-21
 Identities = 77/274 (28%), Positives = 123/274 (44%), Gaps = 16/274 (5%)

Query: 706  RDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYI 765
            + RL K+++ +    A+   C +AQ E N +KNR+   +P + AR+ L        +DYI
Sbjct: 1147 KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYI 1206

Query: 766  NASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVML---TPLVEDGVKQCDR 822
            NAS I+ +  R   +I TQ PL HT  DFW+M+W+    +IVML     L ED       
Sbjct: 1207 NASYIMGYY-RSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV---- 1261

Query: 823  YWPDEGASL-YHVYEVNLVSEHIWC----EDFLVRSFYLKNVQTQETRTLTQFHFLSWPA 877
            YWP    S+    + V L+S+   C    E  ++  F L+  Q      +  F    WP 
Sbjct: 1262 YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPN 1321

Query: 878  EGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEID 937
               P S+    +    + +    R  P IVH   GA   G    +   L++  +    +D
Sbjct: 1322 PDAPISS--TFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCAL-TTLSQQLENENAVD 1378

Query: 938  IAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN 971
            +    + +   RPG+    +Q++F   A+   V+
Sbjct: 1379 VFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS 1412


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  173 bits (439), Expect = 6e-43
 Identities = 96/237 (40%), Positives = 137/237 (57%), Gaps = 3/237 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDYINA+  I+   +  AYIATQGPL  T+
Sbjct: 1373 EVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAN-YIDGYRKQNAYIATQGPLPETM 1431

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+MVWE     +VM+T L E    +CD+YWP  G     + +V L+ + +    + V
Sbjct: 1432 GDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLL-DTVELATYTV 1490

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R L QF F++WP  G P    P+L F R+V  C    + P++VHCS 
Sbjct: 1491 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1550

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
            G GRTG +I+ID +L RM K  K +DI   +  +R QR  +V+++DQ+ F   A+ E
Sbjct: 1551 GVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606



 Score =  172 bits (435), Expect = 2e-42
 Identities = 96/260 (36%), Positives = 155/260 (59%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  +
Sbjct: 1642 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAS-FL 1700

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ +  DFW+M+WE   T+IVMLT L E G ++C +YWP E ++ 
Sbjct: 1701 DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR 1760

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P +    +DF 
Sbjct: 1761 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFI 1819

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +D+  T++ +R Q
Sbjct: 1820 GQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV--VDMFQTVKTLRTQ 1877

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++    A  E
Sbjct: 1878 RPAMVQTEDQYQLCYRAALE 1897


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  173 bits (439), Expect = 6e-43
 Identities = 96/237 (40%), Positives = 137/237 (57%), Gaps = 3/237 (1%)

Query: 732  EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTI 791
            E N  KNR+ + + YDH+R+ L        SDYINA+  I+   +  AYIATQGPL  T+
Sbjct: 1364 EVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAN-YIDGYRKQNAYIATQGPLPETM 1422

Query: 792  ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLV 851
             DFW+MVWE     +VM+T L E    +CD+YWP  G     + +V L+ + +    + V
Sbjct: 1423 GDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLL-DTVELATYTV 1481

Query: 852  RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD 911
            R+F L    + E R L QF F++WP  G P    P+L F R+V  C    + P++VHCS 
Sbjct: 1482 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1541

Query: 912  GAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
            G GRTG +I+ID +L RM K  K +DI   +  +R QR  +V+++DQ+ F   A+ E
Sbjct: 1542 GVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597



 Score =  172 bits (435), Expect = 2e-42
 Identities = 96/260 (36%), Positives = 155/260 (59%), Gaps = 7/260 (2%)

Query: 712  EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPII 771
            E++ L + +A  +   +A    N  KNR  + +PY+  R+ L+       SDYINAS  +
Sbjct: 1633 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAS-FL 1691

Query: 772  EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL 831
            +   +  AYIATQGPL+ +  DFW+M+WE   T+IVMLT L E G ++C +YWP E ++ 
Sbjct: 1692 DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR 1751

Query: 832  YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR 891
            Y  + V+ ++E+     +++R F + + +  ++RT+ QF F  WP +G P +    +DF 
Sbjct: 1752 YQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFI 1810

Query: 892  RKVNKCYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQ 948
             +V+K     G+  PI VHCS G GRTG +I + +VL RM  +GV  +D+  T++ +R Q
Sbjct: 1811 GQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV--VDMFQTVKTLRTQ 1868

Query: 949  RPGLVRSKDQFEFALTAVAE 968
            RP +V+++DQ++    A  E
Sbjct: 1869 RPAMVQTEDQYQLCYRAALE 1888


>gi|196114951 protein tyrosine phosphatase, non-receptor type 12
           isoform 1 [Homo sapiens]
          Length = 780

 Score =  172 bits (435), Expect = 2e-42
 Identities = 100/280 (35%), Positives = 154/280 (55%), Gaps = 20/280 (7%)

Query: 701 DHLRNRDRLAKEWQALCAYQAEPNT-----CATAQGEGNIKKNRHPDFLPYDHARIKLKV 755
           DH    D  A+++  L     +  T      AT + E N+KKNR+ D LP+DH+R+KL +
Sbjct: 21  DH-NGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTL 79

Query: 756 ESSPSRSDYINASPIIE-HDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVE 814
           ++    SDYINA+ I   + P+  AY+ATQGPL++T+ DFW+M+WE    +IVM     E
Sbjct: 80  KTPSQDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFE 137

Query: 815 DGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRS-FYLKNVQTQ---ETRTLTQF 870
            G K+C+RYWP     LY    +      I CED   R+ ++++ +  +   E+R L QF
Sbjct: 138 MGRKKCERYWP-----LYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQF 192

Query: 871 HFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMA 930
           H+++WP    P+S   +LD    + K       PI +HCS G GRTG    ID   N + 
Sbjct: 193 HYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK 252

Query: 931 KG--VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
            G   +E ++   ++ +R QR   V++K+Q+E    A+A+
Sbjct: 253 AGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ 292


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  170 bits (431), Expect = 5e-42
 Identities = 91/241 (37%), Positives = 143/241 (59%), Gaps = 4/241 (1%)

Query: 728  TAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPL 787
            +A+ + N  KNR+ + + YDH+R++L+     + SDYIN +  I+   R   YIATQGP+
Sbjct: 917  SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGN-YIDGYHRPNHYIATQGPM 975

Query: 788  SHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCE 847
              TI DFW+MVW      I+M+T LVE G  +C +YWPD+   +Y   +V L+   +  E
Sbjct: 976  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAE 1034

Query: 848  DFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIV 907
             +++R+F ++     E R + QFHF  WP  G P     LL F R+V       + P++V
Sbjct: 1035 -YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1093

Query: 908  HCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA 967
            HCS GAGRTG +I+ID++L+ MA+    +DI   +  +R +R  +V++++Q+ F   A+ 
Sbjct: 1094 HCSAGAGRTGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL 1152

Query: 968  E 968
            E
Sbjct: 1153 E 1153



 Score =  127 bits (319), Expect = 5e-29
 Identities = 82/253 (32%), Positives = 131/253 (51%), Gaps = 12/253 (4%)

Query: 726  CATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQG 785
            C+ A    N +KNR  D LP D   +   +      S+YINA+ +++   +  A+I TQ 
Sbjct: 1205 CSIALLPRNHEKNRCMDILPPDRC-LPFLITIDGESSNYINAA-LMDSYKQPSAFIVTQH 1262

Query: 786  PLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIW 845
            PL +T+ DFW++V +  CT +VML  +  D  + C +YWP+ G   +   +V  VS  + 
Sbjct: 1263 PLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320

Query: 846  CEDFLVRSFYLKNVQTQET--RTLTQFHFLSWPA-EGTPASTRPLLDFRRKVNKC---YR 899
             ED + R F + N    +   R + QF FL WP    TP S R  L   R+V+K    Y 
Sbjct: 1321 -EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYN 1379

Query: 900  GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF 959
            G     +VHC +G GR+GT+  I +V   M +  + +D+   ++ +R+ +P +V   DQ+
Sbjct: 1380 GGEGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQY 1438

Query: 960  EFALTAVAEEVNA 972
            +F      E +N+
Sbjct: 1439 KFCYEVALEYLNS 1451


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  170 bits (431), Expect = 5e-42
 Identities = 91/241 (37%), Positives = 143/241 (59%), Gaps = 4/241 (1%)

Query: 728  TAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPL 787
            +A+ + N  KNR+ + + YDH+R++L+     + SDYIN +  I+   R   YIATQGP+
Sbjct: 930  SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGN-YIDGYHRPNHYIATQGPM 988

Query: 788  SHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCE 847
              TI DFW+MVW      I+M+T LVE G  +C +YWPD+   +Y   +V L+   +  E
Sbjct: 989  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAE 1047

Query: 848  DFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIV 907
             +++R+F ++     E R + QFHF  WP  G P     LL F R+V       + P++V
Sbjct: 1048 -YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1106

Query: 908  HCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA 967
            HCS GAGRTG +I+ID++L+ MA+    +DI   +  +R +R  +V++++Q+ F   A+ 
Sbjct: 1107 HCSAGAGRTGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL 1165

Query: 968  E 968
            E
Sbjct: 1166 E 1166



 Score =  127 bits (319), Expect = 5e-29
 Identities = 82/253 (32%), Positives = 131/253 (51%), Gaps = 12/253 (4%)

Query: 726  CATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQG 785
            C+ A    N +KNR  D LP D   +   +      S+YINA+ +++   +  A+I TQ 
Sbjct: 1218 CSIALLPRNHEKNRCMDILPPDRC-LPFLITIDGESSNYINAA-LMDSYKQPSAFIVTQH 1275

Query: 786  PLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIW 845
            PL +T+ DFW++V +  CT +VML  +  D  + C +YWP+ G   +   +V  VS  + 
Sbjct: 1276 PLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1333

Query: 846  CEDFLVRSFYLKNVQTQET--RTLTQFHFLSWPA-EGTPASTRPLLDFRRKVNKC---YR 899
             ED + R F + N    +   R + QF FL WP    TP S R  L   R+V+K    Y 
Sbjct: 1334 -EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYN 1392

Query: 900  GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF 959
            G     +VHC +G GR+GT+  I +V   M +  + +D+   ++ +R+ +P +V   DQ+
Sbjct: 1393 GGEGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQY 1451

Query: 960  EFALTAVAEEVNA 972
            +F      E +N+
Sbjct: 1452 KFCYEVALEYLNS 1464


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  170 bits (430), Expect = 7e-42
 Identities = 139/451 (30%), Positives = 222/451 (49%), Gaps = 45/451 (9%)

Query: 539  SELEAQTGLQILQTGV-GQREEAAAVLPQTAHSTSPMRSVLLTLVALAGV-AGLLVALAV 596
            S +E +T  Q ++        E   V+P  A  T         +V +AG+ AG+LV + +
Sbjct: 715  SSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTD-------RVVKIAGISAGILVFILL 767

Query: 597  ALCVRQHARQQD--KERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRV 654
             L V    ++    K+R  A+G      + T     + R +    +L   AE P      
Sbjct: 768  LLVVILIVKKSKLAKKRKDAMG--NTRQEMTHMVNAMDRSYADQSTL--HAEDP------ 817

Query: 655  SSVSSQFSDAAQASP--SSHSST---------PSWCEEPAQANMDISTGHMILAYME--- 700
              +S  F D    SP   +HS+T         P +  E  ++       H  +   +   
Sbjct: 818  --LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQ 875

Query: 701  --DHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLK-VES 757
              + ++  D    + +    ++ +  +   A+ + N  KNR+ + + YDH+R+ L+ VE 
Sbjct: 876  HINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED 935

Query: 758  SPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGV 817
             PS SDYINA+  I+   R   YIATQGP+  T+ DFW+M+W+     IVM+T LVE G 
Sbjct: 936  DPS-SDYINAN-YIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGR 993

Query: 818  KQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPA 877
             +C +YWPD+   +Y  ++V  V      E ++VR+F L+     E R + QFHF  WP 
Sbjct: 994  VKCYKYWPDD-TEVYGDFKVTCVEMEPLAE-YVVRTFTLERRGYNEIREVKQFHFTGWPD 1051

Query: 878  EGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEID 937
             G P     LL F R+V       + PI+VHCS GAGRTG YI+ID++L+ MA+    +D
Sbjct: 1052 HGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLD-MAEREGVVD 1110

Query: 938  IAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
            I   ++ +R +R  +V++++Q+ F   A+ E
Sbjct: 1111 IYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141



 Score =  116 bits (291), Expect = 9e-26
 Identities = 85/277 (30%), Positives = 136/277 (49%), Gaps = 16/277 (5%)

Query: 701  DHLRNRDRLAKEWQALCAY--QAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS 758
            D   N   L  E+Q L +   + +   C+ A    N  KNR  D LP D   +   +   
Sbjct: 1166 DSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC-LPFLITID 1224

Query: 759  PSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK 818
               S+YINA+ +++   +  A+I TQ PL +T+ DFW++V++ GCT IVML  +  D  +
Sbjct: 1225 GESSNYINAA-LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQ 1281

Query: 819  QCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTL--TQFHFLSWP 876
             C +YWP+EG   Y   +V  +S  + C D + R F + N+   +   L   QF +L W 
Sbjct: 1282 GCPQYWPEEGMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRPQEGYLMVQQFQYLGWA 1340

Query: 877  A-EGTPASTRPLLDFRRKVNK----CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAK 931
            +    P S R  L    +V K    C  G     I+HC +G GR+G +  I +V+  M K
Sbjct: 1341 SHREVPGSKRSFLKLILQVEKWQEECEEGEG-RTIIHCLNGGGRSGMFCAIGIVV-EMVK 1398

Query: 932  GVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
                +D+   ++ +R+ +P +V + +Q+ F      E
Sbjct: 1399 RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1435


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  167 bits (422), Expect = 6e-41
 Identities = 140/456 (30%), Positives = 223/456 (48%), Gaps = 49/456 (10%)

Query: 539  SELEAQTGLQILQTGV-GQREEAAAVLPQTAHSTSPMRSVLLTLVALAGV-AGLLVALAV 596
            S +E +T  Q ++        E   V+P  A  T         +V +AG+ AG+LV + +
Sbjct: 715  SSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTD-------RVVKIAGISAGILVFILL 767

Query: 597  ALCVRQHARQQD--KERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRV 654
             L V    ++    K+R  A+G      + T     + R +    +L   AE P      
Sbjct: 768  LLVVILIVKKSKLAKKRKDAMG--NTRQEMTHMVNAMDRSYADQSTL--HAEDP------ 817

Query: 655  SSVSSQFSDAAQASP--SSHSST---------PSWCEEPAQANMDISTGHMILAYME--- 700
              +S  F D    SP   +HS+T         P +  E  ++       H  +   +   
Sbjct: 818  --LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQ 875

Query: 701  --DHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLK-VES 757
              + ++  D    + +    ++ +  +   A+ + N  KNR+ + + YDH+R+ L+ VE 
Sbjct: 876  HINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED 935

Query: 758  SPSRSDYINASPI---IEHD--PRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPL 812
             PS SDYINA+ I   +  D   R   YIATQGP+  T+ DFW+M+W+     IVM+T L
Sbjct: 936  DPS-SDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNL 994

Query: 813  VEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHF 872
            VE G  +C +YWPD+   +Y  ++V  V      E ++VR+F L+     E R + QFHF
Sbjct: 995  VEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAE-YVVRTFTLERRGYNEIREVKQFHF 1052

Query: 873  LSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG 932
              WP  G P     LL F R+V       + PI+VHCS GAGRTG YI+ID++L+ MA+ 
Sbjct: 1053 TGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLD-MAER 1111

Query: 933  VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
               +DI   ++ +R +R  +V++++Q+ F   A+ E
Sbjct: 1112 EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1147



 Score =  116 bits (291), Expect = 9e-26
 Identities = 85/277 (30%), Positives = 136/277 (49%), Gaps = 16/277 (5%)

Query: 701  DHLRNRDRLAKEWQALCAY--QAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS 758
            D   N   L  E+Q L +   + +   C+ A    N  KNR  D LP D   +   +   
Sbjct: 1172 DSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC-LPFLITID 1230

Query: 759  PSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK 818
               S+YINA+ +++   +  A+I TQ PL +T+ DFW++V++ GCT IVML  +  D  +
Sbjct: 1231 GESSNYINAA-LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQ 1287

Query: 819  QCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTL--TQFHFLSWP 876
             C +YWP+EG   Y   +V  +S  + C D + R F + N+   +   L   QF +L W 
Sbjct: 1288 GCPQYWPEEGMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRPQEGYLMVQQFQYLGWA 1346

Query: 877  A-EGTPASTRPLLDFRRKVNK----CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAK 931
            +    P S R  L    +V K    C  G     I+HC +G GR+G +  I +V+  M K
Sbjct: 1347 SHREVPGSKRSFLKLILQVEKWQEECEEGEG-RTIIHCLNGGGRSGMFCAIGIVV-EMVK 1404

Query: 932  GVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968
                +D+   ++ +R+ +P +V + +Q+ F      E
Sbjct: 1405 RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441


>gi|224586931 protein tyrosine phosphatase, non-receptor type 22
           (lymphoid) isoform 2 [Homo sapiens]
          Length = 691

 Score =  165 bits (417), Expect = 2e-40
 Identities = 101/257 (39%), Positives = 149/257 (57%), Gaps = 13/257 (5%)

Query: 719 YQAEPNTCAT-AQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE-HDPR 776
           Y+A+     T A+   NIKKNR+ D LPYD++R++L + +S   S YINA+ I   + P+
Sbjct: 38  YKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPK 97

Query: 777 MPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW--PDEGASLYHV 834
             AYIATQGPLS T+ DFW+M+WE    +IVM     E G K+C+RYW  P E    +  
Sbjct: 98  --AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGP 155

Query: 835 YEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKV 894
           + V+  +E     D+++R+  LK     ETRT+ QFH+ +WP    P+S  P+L+    V
Sbjct: 156 FSVSCEAEK-RKSDYIIRT--LKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV 212

Query: 895 NKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGV--KEIDIAATLEHVRDQRPG 951
            +CY+   S PI +HCS G GRTG    ID     +  G+  +   + + +  +R QRP 
Sbjct: 213 -RCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPS 271

Query: 952 LVRSKDQFEFALTAVAE 968
           LV++++Q+E    AV E
Sbjct: 272 LVQTQEQYELVYNAVLE 288


>gi|224586929 protein tyrosine phosphatase, non-receptor type 22
           (lymphoid) isoform 1 [Homo sapiens]
          Length = 807

 Score =  165 bits (417), Expect = 2e-40
 Identities = 101/257 (39%), Positives = 149/257 (57%), Gaps = 13/257 (5%)

Query: 719 YQAEPNTCAT-AQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE-HDPR 776
           Y+A+     T A+   NIKKNR+ D LPYD++R++L + +S   S YINA+ I   + P+
Sbjct: 38  YKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPK 97

Query: 777 MPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW--PDEGASLYHV 834
             AYIATQGPLS T+ DFW+M+WE    +IVM     E G K+C+RYW  P E    +  
Sbjct: 98  --AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGP 155

Query: 835 YEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKV 894
           + V+  +E     D+++R+  LK     ETRT+ QFH+ +WP    P+S  P+L+    V
Sbjct: 156 FSVSCEAEK-RKSDYIIRT--LKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV 212

Query: 895 NKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGV--KEIDIAATLEHVRDQRPG 951
            +CY+   S PI +HCS G GRTG    ID     +  G+  +   + + +  +R QRP 
Sbjct: 213 -RCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPS 271

Query: 952 LVRSKDQFEFALTAVAE 968
           LV++++Q+E    AV E
Sbjct: 272 LVQTQEQYELVYNAVLE 288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,394,913
Number of Sequences: 37866
Number of extensions: 2562297
Number of successful extensions: 16689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 13549
Number of HSP's gapped (non-prelim): 3099
length of query: 979
length of database: 18,247,518
effective HSP length: 112
effective length of query: 867
effective length of database: 14,006,526
effective search space: 12143658042
effective search space used: 12143658042
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.