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Search of human proteins with 4506289
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506289 protein tyrosine phosphatase, non-receptor type 1
[Homo sapiens]
(435 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Ho... 902 0.0
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso... 464 e-131
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H... 450 e-126
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is... 450 e-126
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 197 2e-50
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 197 2e-50
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 196 3e-50
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 189 4e-48
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 186 3e-47
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 186 3e-47
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 186 3e-47
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 186 3e-47
gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Ho... 183 2e-46
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 182 5e-46
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 182 5e-46
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 182 7e-46
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 182 7e-46
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 182 7e-46
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 182 7e-46
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 180 2e-45
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 179 4e-45
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 179 4e-45
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 179 6e-45
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 179 6e-45
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 179 6e-45
>gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Homo
sapiens]
Length = 435
Score = 902 bits (2332), Expect = 0.0
Identities = 435/435 (100%), Positives = 435/435 (100%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
Sbjct: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
Query: 61 QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK 120
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
Sbjct: 61 QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK 120
Query: 121 CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP 180
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
Sbjct: 121 CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP 180
Query: 181 DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD 240
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
Sbjct: 181 DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD 240
Query: 241 PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE 300
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
Sbjct: 241 PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE 300
Query: 301 PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG 360
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
Sbjct: 301 PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG 360
Query: 361 IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT 420
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
Sbjct: 361 IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT 420
Query: 421 AGAYLCYRFLFNSNT 435
AGAYLCYRFLFNSNT
Sbjct: 421 AGAYLCYRFLFNSNT 435
>gi|4506291 protein tyrosine phosphatase, non-receptor type 2
isoform 1 [Homo sapiens]
Length = 415
Score = 464 bits (1195), Expect = e-131
Identities = 237/439 (53%), Positives = 306/439 (69%), Gaps = 37/439 (8%)
Query: 3 MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE 62
+E+EFE++D W +Y +IR+E+ D+P RVAK P+N+NRNRYRDVSP+DHSR+KL
Sbjct: 5 IEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA 64
Query: 63 DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCA 122
+NDYINASL+ +EEAQRSYILTQGPLPNTC HFW MVW+QK++ VVMLNR++EK S+KCA
Sbjct: 65 ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCA 124
Query: 123 QYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDF 182
QYWP +++EM+F++T + L+SED+KSYYTV L+LEN+ + ETR I HFHYTTWPDF
Sbjct: 125 QYWP-TDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDF 183
Query: 183 GVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPS 242
GVPESPASFLNFLFKVRESGSL+P+HGP V+HCSAGIGRSGTF L DTCL+LM+K D
Sbjct: 184 GVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD-- 241
Query: 243 SVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPP 302
++IK+VLL MRK+RMGLIQT DQLRFSY+A+IEGAK I GDSS+Q +WKELS EDL P
Sbjct: 242 -INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA 300
Query: 303 PEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIE 362
+H P K + E +NG N ++EE C G+
Sbjct: 301 FDH-----SPNKIMTEKYNG-------NRIGLEEEKLTGDRCT--------------GLS 334
Query: 363 SMSQDT--EVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALS-----YWKPFLVNMCV 415
S QDT E + +R + A+ A+ + ++ ++ YW+P L M
Sbjct: 335 SKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGF 394
Query: 416 ATVLTAGAYLCYRFLFNSN 434
+V+ GA++ +R F N
Sbjct: 395 MSVILVGAFVGWRLFFQQN 413
>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
sapiens]
Length = 353
Score = 450 bits (1158), Expect = e-126
Identities = 213/320 (66%), Positives = 263/320 (82%), Gaps = 9/320 (2%)
Query: 3 MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE 62
+E+EFE++D W +Y +IR+E+ D+P RVAK P+N+NRNRYRDVSP+DHSR+KL
Sbjct: 5 IEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA 64
Query: 63 DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCA 122
+NDYINASL+ +EEAQRSYILTQGPLPNTC HFW MVW+QK++ VVMLNR++EK S+KCA
Sbjct: 65 ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCA 124
Query: 123 QYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDF 182
QYWP +++EM+F++T + L+SED+KSYYTV L+LEN+ + ETR I HFHYTTWPDF
Sbjct: 125 QYWP-TDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDF 183
Query: 183 GVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPS 242
GVPESPASFLNFLFKVRESGSL+P+HGP V+HCSAGIGRSGTF L DTCL+LM+K D
Sbjct: 184 GVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD-- 241
Query: 243 SVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPP 302
++IK+VLL MRK+RMGLIQT DQLRFSY+A+IEGAK I GDSS+Q +WKELS EDL P
Sbjct: 242 -INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA 300
Query: 303 PEHIPPPPRPPKRILEPHNG 322
+H P K + E +NG
Sbjct: 301 FDH-----SPNKIMTEKYNG 315
>gi|18104980 protein tyrosine phosphatase, non-receptor type 2
isoform 2 [Homo sapiens]
Length = 387
Score = 450 bits (1158), Expect = e-126
Identities = 213/320 (66%), Positives = 263/320 (82%), Gaps = 9/320 (2%)
Query: 3 MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE 62
+E+EFE++D W +Y +IR+E+ D+P RVAK P+N+NRNRYRDVSP+DHSR+KL
Sbjct: 5 IEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA 64
Query: 63 DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCA 122
+NDYINASL+ +EEAQRSYILTQGPLPNTC HFW MVW+QK++ VVMLNR++EK S+KCA
Sbjct: 65 ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCA 124
Query: 123 QYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDF 182
QYWP +++EM+F++T + L+SED+KSYYTV L+LEN+ + ETR I HFHYTTWPDF
Sbjct: 125 QYWP-TDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDF 183
Query: 183 GVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPS 242
GVPESPASFLNFLFKVRESGSL+P+HGP V+HCSAGIGRSGTF L DTCL+LM+K D
Sbjct: 184 GVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD-- 241
Query: 243 SVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPP 302
++IK+VLL MRK+RMGLIQT DQLRFSY+A+IEGAK I GDSS+Q +WKELS EDL P
Sbjct: 242 -INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA 300
Query: 303 PEHIPPPPRPPKRILEPHNG 322
+H P K + E +NG
Sbjct: 301 FDH-----SPNKIMTEKYNG 315
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 197 bits (500), Expect = 2e-50
Identities = 107/273 (39%), Positives = 161/273 (58%), Gaps = 15/273 (5%)
Query: 9 QIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDND--- 65
Q D + + Y++++ + C +A LP+N+ +NRY ++ P+D +R+KL D+D
Sbjct: 1914 QADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCS 1973
Query: 66 -YINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY 124
YINAS I +R YI+TQGPLP T FW+MVWEQ +VM+ + +EKG +KC Y
Sbjct: 1974 DYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHY 2033
Query: 125 WPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL---ENLTTQETREILHFHYTTWPD 181
WP ++ + + D L L ++SE + +T+R+ ++ E L R I HFHYT WPD
Sbjct: 2034 WPADQDS-LYYGD--LILQMLSESVLPEWTIREFKICGEEQLDAH--RLIRHFHYTVWPD 2088
Query: 182 FGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDP 241
GVPE+ S + F+ VR+ + SP GP VVHCSAG+GR+GTF D L +D +
Sbjct: 2089 HGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSK--- 2145
Query: 242 SSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274
SVDI + ++R R+ ++QT Q + + V
Sbjct: 2146 DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 197 bits (500), Expect = 2e-50
Identities = 107/273 (39%), Positives = 161/273 (58%), Gaps = 15/273 (5%)
Query: 9 QIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDND--- 65
Q D + + Y++++ + C +A LP+N+ +NRY ++ P+D +R+KL D+D
Sbjct: 1696 QADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCS 1755
Query: 66 -YINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY 124
YINAS I +R YI+TQGPLP T FW+MVWEQ +VM+ + +EKG +KC Y
Sbjct: 1756 DYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHY 1815
Query: 125 WPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL---ENLTTQETREILHFHYTTWPD 181
WP ++ + + D L L ++SE + +T+R+ ++ E L R I HFHYT WPD
Sbjct: 1816 WPADQDS-LYYGD--LILQMLSESVLPEWTIREFKICGEEQLDAH--RLIRHFHYTVWPD 1870
Query: 182 FGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDP 241
GVPE+ S + F+ VR+ + SP GP VVHCSAG+GR+GTF D L +D +
Sbjct: 1871 HGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSK--- 1927
Query: 242 SSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274
SVDI + ++R R+ ++QT Q + + V
Sbjct: 1928 DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 196 bits (499), Expect = 3e-50
Identities = 105/301 (34%), Positives = 174/301 (57%), Gaps = 15/301 (4%)
Query: 8 EQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQED 63
+Q D + +A Y+D++ P A+L +N+ +NRY +V P+D SR+KL H D
Sbjct: 1033 QQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTD 1092
Query: 64 NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQ 123
DYINA+ + +++ +I TQGPLPNT FW MVWE+ ++ML + +E+G KC +
Sbjct: 1093 -DYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEE 1151
Query: 124 YWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFG 183
YWP K+ ++ + D + +T SE + +T+R ++N+ T E+ + FH+T+WPD G
Sbjct: 1152 YWPSKQAQD--YGDITVAMT--SEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHG 1207
Query: 184 VPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSS 243
VP++ +NF + VR+ SP P++VHCSAG+GR+GTF D L+ + ++ ++
Sbjct: 1208 VPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDR---LIYQIENENT 1264
Query: 244 VDIKKVLLEMRKFRMGLIQTADQLRF---SYLAVIEGAKFIMGDSSVQDQWKELSHEDLE 300
VD+ ++ ++R R ++QT DQ F L ++ K D Q+ +E+L
Sbjct: 1265 VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLA 1324
Query: 301 P 301
P
Sbjct: 1325 P 1325
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 189 bits (480), Expect = 4e-48
Identities = 106/300 (35%), Positives = 162/300 (54%), Gaps = 31/300 (10%)
Query: 39 KNKNRNRYRDVSPFDHSRIKLHQED-----NDYINASLIKME--------EAQRSYILTQ 85
+NKN+NRY+++ PFDH+R+ LH D +DYINA++I E + ++SYI TQ
Sbjct: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
Query: 86 GPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLI 145
G L NT FW MV+++ SR +VM + +E+G KC +YWP ++ + E +++ +
Sbjct: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP---DEYALKEYGVMRVRNV 388
Query: 146 SEDIKSYYTVRQLELENLTTQET-REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL 204
E YT+R+L+L + T R + +H+ TWPD GVP P L+FL +V
Sbjct: 389 KESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES 448
Query: 205 SPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTA 264
+ GPVVVHCSAGIGR+GTF + D + ++ ++ +D+ K + +R R G++QT
Sbjct: 449 IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE 508
Query: 265 DQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE--------------DLEPPPEHIPPPP 310
Q RF Y+AV + + + + K HE D P P P PP
Sbjct: 509 AQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPP 568
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 186 bits (473), Expect = 3e-47
Identities = 104/280 (37%), Positives = 154/280 (55%), Gaps = 27/280 (9%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
+++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 948 LKLSQEYESIDPG--------------QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 993
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
+ +DYINA+ + Q +YI TQGPLP T G FW MVWEQ+S +VM+ R+ EK
Sbjct: 994 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1053
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + F +++TL+ + + VR L + E RE+ F +
Sbjct: 1054 SRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
T WPD GVPE P FL FL +V+ P+ GP+VVHCSAG+GR+G F + D +++
Sbjct: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDA---MLE 1164
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
+ K +VD+ + MR R ++QT DQ F + A++E
Sbjct: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1204
Score = 159 bits (403), Expect = 4e-39
Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS I Q++YI TQGPL
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
T FW M+WE S VVML ++ E G KC QYWP + + + ++E
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1372
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R + F +T WP+ GVP+S F++F+ +V ++ + GP
Sbjct: 1373 PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1432
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VDI + + +R R ++QT D+ +F
Sbjct: 1433 ISVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFC 1489
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1490 YQAALE 1495
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 186 bits (473), Expect = 3e-47
Identities = 104/280 (37%), Positives = 154/280 (55%), Gaps = 27/280 (9%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
+++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 1353 LKLSQEYESIDPG--------------QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 1398
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
+ +DYINA+ + Q +YI TQGPLP T G FW MVWEQ+S +VM+ R+ EK
Sbjct: 1399 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1458
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + F +++TL+ + + VR L + E RE+ F +
Sbjct: 1459 SRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
T WPD GVPE P FL FL +V+ P+ GP+VVHCSAG+GR+G F + D +++
Sbjct: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDA---MLE 1569
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
+ K +VD+ + MR R ++QT DQ F + A++E
Sbjct: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1609
Score = 159 bits (403), Expect = 4e-39
Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS I Q++YI TQGPL
Sbjct: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
T FW M+WE S VVML ++ E G KC QYWP + + + ++E
Sbjct: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1777
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R + F +T WP+ GVP+S F++F+ +V ++ + GP
Sbjct: 1778 PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1837
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VDI + + +R R ++QT D+ +F
Sbjct: 1838 ISVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFC 1894
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1895 YQAALE 1900
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 186 bits (473), Expect = 3e-47
Identities = 104/280 (37%), Positives = 154/280 (55%), Gaps = 27/280 (9%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
+++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 944 LKLSQEYESIDPG--------------QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 989
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
+ +DYINA+ + Q +YI TQGPLP T G FW MVWEQ+S +VM+ R+ EK
Sbjct: 990 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1049
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + F +++TL+ + + VR L + E RE+ F +
Sbjct: 1050 SRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
T WPD GVPE P FL FL +V+ P+ GP+VVHCSAG+GR+G F + D +++
Sbjct: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDA---MLE 1160
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
+ K +VD+ + MR R ++QT DQ F + A++E
Sbjct: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1200
Score = 159 bits (403), Expect = 4e-39
Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS I Q++YI TQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
T FW M+WE S VVML ++ E G KC QYWP + + + ++E
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1368
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R + F +T WP+ GVP+S F++F+ +V ++ + GP
Sbjct: 1369 PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1428
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VDI + + +R R ++QT D+ +F
Sbjct: 1429 ISVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFC 1485
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1486 YQAALE 1491
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 186 bits (473), Expect = 3e-47
Identities = 104/280 (37%), Positives = 154/280 (55%), Gaps = 27/280 (9%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
+++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 1391 LKLSQEYESIDPG--------------QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 1436
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
+ +DYINA+ + Q +YI TQGPLP T G FW MVWEQ+S +VM+ R+ EK
Sbjct: 1437 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1496
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + F +++TL+ + + VR L + E RE+ F +
Sbjct: 1497 SRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
T WPD GVPE P FL FL +V+ P+ GP+VVHCSAG+GR+G F + D +++
Sbjct: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDA---MLE 1607
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
+ K +VD+ + MR R ++QT DQ F + A++E
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1647
Score = 159 bits (403), Expect = 4e-39
Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS I Q++YI TQGPL
Sbjct: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
T FW M+WE S VVML ++ E G KC QYWP + + + ++E
Sbjct: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1815
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R + F +T WP+ GVP+S F++F+ +V ++ + GP
Sbjct: 1816 PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1875
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VDI + + +R R ++QT D+ +F
Sbjct: 1876 ISVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFC 1932
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1933 YQAALE 1938
>gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Homo
sapiens]
Length = 593
Score = 183 bits (465), Expect = 2e-46
Identities = 109/278 (39%), Positives = 156/278 (56%), Gaps = 26/278 (9%)
Query: 20 YQDIRHE--ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDN----DYINASLIK 73
Y+DIR E F C ++ P N +NRY DV D +R+KL + DYINAS +
Sbjct: 307 YEDIRRENPVGTFHCSMS--PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMD 364
Query: 74 MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEM 133
+ + +YI TQGPL NT FW MVWEQK +VM R E G KC QYWP +++ +
Sbjct: 365 GYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRI 424
Query: 134 IFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLN 193
F L +T + + ++Y LE+ N ++ R++ HF + +WPD+GVP S AS ++
Sbjct: 425 RF--GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLID 482
Query: 194 FLFKVRESGSLS------------PEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDP 241
FL VR SL+ PE P+VVHCSAGIGR+GTFC D CL ++ +
Sbjct: 483 FLRVVRNQQSLAVSNMGARSKGQCPE-PPIVVHCSAGIGRTGTFCSLDICLAQLE---EL 538
Query: 242 SSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAK 279
++++ + + MR R IQT +Q F Y A++E A+
Sbjct: 539 GTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE 576
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 182 bits (462), Expect = 5e-46
Identities = 110/310 (35%), Positives = 161/310 (51%), Gaps = 27/310 (8%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 1350 LKFSQEYESIDPG--------------QQFTWENSNLEVNKPKNRYANVIAYDHSRVILT 1395
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
D +DYINA+ I Q +YI TQGPLP T G FW MVWEQ++ VVM+ R+ EK
Sbjct: 1396 SIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEK 1455
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + +++TL+ + YTVR L + E RE+ F +
Sbjct: 1456 SRVKCDQYWPARGTETCGL----IQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1511
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
WPD GVPE P L FL +V+ L + GP+VVHCSAG+GR+G F + D +++
Sbjct: 1512 MAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDA---MLE 1566
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSH 296
+ K +VDI + MR R ++QT DQ F + A++E A + ++ + +
Sbjct: 1567 RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK 1626
Query: 297 EDLEPPPEHI 306
PP E +
Sbjct: 1627 LGQVPPGESV 1636
Score = 154 bits (389), Expect = 2e-37
Identities = 81/246 (32%), Positives = 137/246 (55%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS + Q++YI TQGPL
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
+ FW M+WE S +VML ++ E G KC QYWP + + + ++E
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1774
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R I F +T WP+ GVP++ F++F+ +V ++ + GP
Sbjct: 1775 PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGP 1834
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VD+ + + +R R ++QT DQ +
Sbjct: 1835 ITVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1891
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1892 YRAALE 1897
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 182 bits (462), Expect = 5e-46
Identities = 110/310 (35%), Positives = 161/310 (51%), Gaps = 27/310 (8%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 60
++ +E+E ID F + L NK +NRY +V +DHSR+ L
Sbjct: 1341 LKFSQEYESIDPG--------------QQFTWENSNLEVNKPKNRYANVIAYDHSRVILT 1386
Query: 61 QED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK 116
D +DYINA+ I Q +YI TQGPLP T G FW MVWEQ++ VVM+ R+ EK
Sbjct: 1387 SIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEK 1446
Query: 117 GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHY 176
+KC QYWP + + +++TL+ + YTVR L + E RE+ F +
Sbjct: 1447 SRVKCDQYWPARGTETCGL----IQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1502
Query: 177 TTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD 236
WPD GVPE P L FL +V+ L + GP+VVHCSAG+GR+G F + D +++
Sbjct: 1503 MAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDA---MLE 1557
Query: 237 KRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSH 296
+ K +VDI + MR R ++QT DQ F + A++E A + ++ + +
Sbjct: 1558 RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK 1617
Query: 297 EDLEPPPEHI 306
PP E +
Sbjct: 1618 LGQVPPGESV 1627
Score = 154 bits (389), Expect = 2e-37
Identities = 81/246 (32%), Positives = 137/246 (55%), Gaps = 11/246 (4%)
Query: 35 AKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPN 90
A LP NK +NR ++ P++ +R+ L E +DYINAS + Q++YI TQGPL
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 91 TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK 150
+ FW M+WE S +VML ++ E G KC QYWP + + + ++E
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQY----FVVDPMAEYNM 1765
Query: 151 SYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGP 210
Y +R+ ++ + ++R I F +T WP+ GVP++ F++F+ +V ++ + GP
Sbjct: 1766 PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGP 1825
Query: 211 VVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFS 270
+ VHCSAG+GR+G F T +++++ + VD+ + + +R R ++QT DQ +
Sbjct: 1826 ITVHCSAGVGRTGVFI---TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1882
Query: 271 YLAVIE 276
Y A +E
Sbjct: 1883 YRAALE 1888
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 182 bits (461), Expect = 7e-46
Identities = 99/256 (38%), Positives = 149/256 (58%), Gaps = 26/256 (10%)
Query: 38 PKNKNRNRYRDVSPFDHSRIKLH------QEDNDYINASLIKMEEAQRSYILTQGPLPNT 91
P+NK++NRY ++ +DHSR+KL + +DYINA+ + ++YI TQGPL +T
Sbjct: 872 PENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKST 931
Query: 92 CGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKS 151
FW M+WEQ + +VM+ ++EKG KC QYWP + +E N+ +TL S I +
Sbjct: 932 FEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEY----GNIIVTLKSTKIHA 987
Query: 152 YYTVRQLELENLTT-----------QETREILHFHYTTWPDFGVPESPASFLNFLFKVRE 200
YTVR+ + N Q R ++ +HYT WPD GVPE L F+ R
Sbjct: 988 CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFV--RRS 1045
Query: 201 SGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGL 260
S + PE GPV+VHCSAG+GR+GT+ + D+ ++ + KD S+V++ L +R R L
Sbjct: 1046 SAARMPETGPVLVHCSAGVGRTGTYIVIDS---MLQQIKDKSTVNVLGFLKHIRTQRNYL 1102
Query: 261 IQTADQLRFSYLAVIE 276
+QT +Q F + A++E
Sbjct: 1103 VQTEEQYIFIHDALLE 1118
Score = 99.0 bits (245), Expect = 8e-21
Identities = 73/255 (28%), Positives = 121/255 (47%), Gaps = 24/255 (9%)
Query: 32 CRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGP 87
C A+ NK +NR V P + +R+ L + DYINAS I +I+TQ P
Sbjct: 1167 CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHP 1226
Query: 88 LPNTCGHFWEMVWEQKSRGVVML--NRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLI 145
LP+T FW M+W+ ++ +VML N+ + + YWP +EE +TLI
Sbjct: 1227 LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF---VYWPSREES---MNCEAFTVTLI 1280
Query: 146 SEDIKSYYTVRQLELENLTTQETR-----EILHFHYTTWPDFGVPESPASFLNFLFKVRE 200
S+D Q+ + + + T+ E+ HF WP+ P++P S L V +
Sbjct: 1281 SKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPN---PDAPISSTFELINVIK 1337
Query: 201 SGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGL 260
+L+ + GP +VH G +G C T L + ++ ++VD+ +V + R G+
Sbjct: 1338 EEALTRD-GPTIVHDEYGAVSAGMLCALTT---LSQQLENENAVDVFQVAKMINLMRPGV 1393
Query: 261 IQTADQLRFSYLAVI 275
+Q +F Y A++
Sbjct: 1394 FTDIEQYQFIYKAML 1408
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 182 bits (461), Expect = 7e-46
Identities = 102/288 (35%), Positives = 156/288 (54%), Gaps = 15/288 (5%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRV-AKLPKNKNRNRYRDVSPFDHSRIKL 59
+ ++E E K+G W + E + R+ + P+NK +NRY+++ PFDHSR+ L
Sbjct: 230 LNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL 289
Query: 60 HQEDN-----DYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVM 109
D+ DYINA+ IK + E ++YI +QG L T FW+M W++ SR +VM
Sbjct: 290 QGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVM 349
Query: 110 LNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQET- 168
R +EKG KC YWP E M +T E + Y +R L++ L +
Sbjct: 350 TTREVEKGRNKCVPYWP---EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLI 406
Query: 169 REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLA 228
REI H+ Y +WPD GVP P L+FL ++ + P GP++VHCSAGIGR+GT +
Sbjct: 407 REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVI 466
Query: 229 DTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
D + + + +DI+K + +R R G++QT Q +F Y+A+ +
Sbjct: 467 DMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 182 bits (461), Expect = 7e-46
Identities = 102/288 (35%), Positives = 156/288 (54%), Gaps = 15/288 (5%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRV-AKLPKNKNRNRYRDVSPFDHSRIKL 59
+ ++E E K+G W + E + R+ + P+NK +NRY+++ PFDHSR+ L
Sbjct: 230 LNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL 289
Query: 60 HQEDN-----DYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVM 109
D+ DYINA+ IK + E ++YI +QG L T FW+M W++ SR +VM
Sbjct: 290 QGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVM 349
Query: 110 LNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQET- 168
R +EKG KC YWP E M +T E + Y +R L++ L +
Sbjct: 350 TTREVEKGRNKCVPYWP---EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLI 406
Query: 169 REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLA 228
REI H+ Y +WPD GVP P L+FL ++ + P GP++VHCSAGIGR+GT +
Sbjct: 407 REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVI 466
Query: 229 DTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
D + + + +DI+K + +R R G++QT Q +F Y+A+ +
Sbjct: 467 DMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 182 bits (461), Expect = 7e-46
Identities = 102/288 (35%), Positives = 156/288 (54%), Gaps = 15/288 (5%)
Query: 1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRV-AKLPKNKNRNRYRDVSPFDHSRIKL 59
+ ++E E K+G W + E + R+ + P+NK +NRY+++ PFDHSR+ L
Sbjct: 232 LNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL 291
Query: 60 HQEDN-----DYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVM 109
D+ DYINA+ IK + E ++YI +QG L T FW+M W++ SR +VM
Sbjct: 292 QGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVM 351
Query: 110 LNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQET- 168
R +EKG KC YWP E M +T E + Y +R L++ L +
Sbjct: 352 TTREVEKGRNKCVPYWP---EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLI 408
Query: 169 REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLA 228
REI H+ Y +WPD GVP P L+FL ++ + P GP++VHCSAGIGR+GT +
Sbjct: 409 REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVI 468
Query: 229 DTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 276
D + + + +DI+K + +R R G++QT Q +F Y+A+ +
Sbjct: 469 DMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 516
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 310 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 368
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 369 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 428
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 429 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 485
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 486 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 542
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 543 R---KMRDQRAMMVQTSSQYKFVCEAIL 567
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 355 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 413
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 414 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 473
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 474 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 530
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 531 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 587
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 588 R---KMRDQRAMMVQTSSQYKFVCEAIL 612
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 466 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 524
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 525 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 584
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 585 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 641
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 642 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 698
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 699 R---KMRDQRAMMVQTSSQYKFVCEAIL 723
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 511 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 569
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 570 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 629
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 630 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 686
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 687 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 743
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 744 R---KMRDQRAMMVQTSSQYKFVCEAIL 768
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 597 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 655
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 656 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 715
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 716 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 772
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 773 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 829
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 830 R---KMRDQRAMMVQTSSQYKFVCEAIL 854
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 180 bits (457), Expect = 2e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 642 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 700
Query: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 701 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 760
Query: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 761 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 817
Query: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 818 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 874
Query: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
+ +MR R ++QT+ Q +F A++
Sbjct: 875 R---KMRDQRAMMVQTSSQYKFVCEAIL 899
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 179 bits (454), Expect = 4e-45
Identities = 96/266 (36%), Positives = 148/266 (55%), Gaps = 16/266 (6%)
Query: 26 EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSY 81
E P AK +N+ +NRY ++ +DHSR++L ++DYIN + I Y
Sbjct: 909 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
Query: 82 ILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLK 141
I TQGP+ T FW MVW + + ++M+ ++E G +KC +YWP E I++D +K
Sbjct: 969 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE---IYKD--IK 1023
Query: 142 LTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRES 201
+TLI ++ + Y +R +E E REI FH+T WPD GVP L F+ +V+
Sbjct: 1024 VTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK 1083
Query: 202 GSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLI 261
P GP+VVHCSAG GR+G F + D +++D + VDI + E+R R+ ++
Sbjct: 1084 S--PPSAGPLVVHCSAGAGRTGCFIVID---IMLDMAEREGVVDIYNCVRELRSRRVNMV 1138
Query: 262 QTADQLRFSYLAVIEGAKFIMGDSSV 287
QT +Q F + A++E + GD+SV
Sbjct: 1139 QTEEQYVFIHDAILEAC--LCGDTSV 1162
Score = 114 bits (285), Expect = 2e-25
Identities = 77/255 (30%), Positives = 125/255 (49%), Gaps = 22/255 (8%)
Query: 32 CRVAKLPKNKNRNRYRDVSPFDHSR---IKLHQEDNDYINASLIKMEEAQRSYILTQGPL 88
C +A LP+N +NR D+ P D I + E ++YINA+L+ + ++I+TQ PL
Sbjct: 1205 CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPL 1264
Query: 89 PNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISED 148
PNT FW +V + VVMLN V + C QYWP+ + +++ +S D
Sbjct: 1265 PNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENG----VHRHGPIQVEFVSAD 1318
Query: 149 IKSYYTVRQLELENLTTQET--REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSP 206
++ R + N + R + F + WP + ++P S +FL +R+
Sbjct: 1319 LEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMY--RDTPVSKRSFLKLIRQVDKWQE 1376
Query: 207 EH----GPVVVHCSAGIGRSGTFC-LADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLI 261
E+ G VVHC G GRSGTFC ++ C +L +R +VD+ + +R + ++
Sbjct: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR----TVDVFHAVKTLRNNKPNMV 1432
Query: 262 QTADQLRFSYLAVIE 276
DQ +F Y +E
Sbjct: 1433 DLLDQYKFCYEVALE 1447
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 179 bits (454), Expect = 4e-45
Identities = 96/266 (36%), Positives = 148/266 (55%), Gaps = 16/266 (6%)
Query: 26 EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSY 81
E P AK +N+ +NRY ++ +DHSR++L ++DYIN + I Y
Sbjct: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
Query: 82 ILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLK 141
I TQGP+ T FW MVW + + ++M+ ++E G +KC +YWP E I++D +K
Sbjct: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE---IYKD--IK 1036
Query: 142 LTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRES 201
+TLI ++ + Y +R +E E REI FH+T WPD GVP L F+ +V+
Sbjct: 1037 VTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK 1096
Query: 202 GSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLI 261
P GP+VVHCSAG GR+G F + D +++D + VDI + E+R R+ ++
Sbjct: 1097 S--PPSAGPLVVHCSAGAGRTGCFIVID---IMLDMAEREGVVDIYNCVRELRSRRVNMV 1151
Query: 262 QTADQLRFSYLAVIEGAKFIMGDSSV 287
QT +Q F + A++E + GD+SV
Sbjct: 1152 QTEEQYVFIHDAILEAC--LCGDTSV 1175
Score = 114 bits (285), Expect = 2e-25
Identities = 77/255 (30%), Positives = 125/255 (49%), Gaps = 22/255 (8%)
Query: 32 CRVAKLPKNKNRNRYRDVSPFDHSR---IKLHQEDNDYINASLIKMEEAQRSYILTQGPL 88
C +A LP+N +NR D+ P D I + E ++YINA+L+ + ++I+TQ PL
Sbjct: 1218 CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPL 1277
Query: 89 PNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISED 148
PNT FW +V + VVMLN V + C QYWP+ + +++ +S D
Sbjct: 1278 PNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENG----VHRHGPIQVEFVSAD 1331
Query: 149 IKSYYTVRQLELENLTTQET--REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSP 206
++ R + N + R + F + WP + ++P S +FL +R+
Sbjct: 1332 LEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMY--RDTPVSKRSFLKLIRQVDKWQE 1389
Query: 207 EH----GPVVVHCSAGIGRSGTFC-LADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLI 261
E+ G VVHC G GRSGTFC ++ C +L +R +VD+ + +R + ++
Sbjct: 1390 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR----TVDVFHAVKTLRNNKPNMV 1445
Query: 262 QTADQLRFSYLAVIE 276
DQ +F Y +E
Sbjct: 1446 DLLDQYKFCYEVALE 1460
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 179 bits (453), Expect = 6e-45
Identities = 101/270 (37%), Positives = 157/270 (58%), Gaps = 16/270 (5%)
Query: 11 DKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDY 66
D ++ +++++ D P A LP N+ +NRY ++ P+D SR++L +E DY
Sbjct: 122 DSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADY 181
Query: 67 INASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWP 126
INA+ I + + YI TQGPLP T FW+MV +QKS+ +VML + EK +KC YWP
Sbjct: 182 INANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP 241
Query: 127 QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPE 186
EE + + D + + +ISE+ + + R + E ++++HF+YT WPD GVP
Sbjct: 242 FTEE-PIAYGD--ITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPT 296
Query: 187 SPA--SFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSV 244
+ A S L F+ VR+ + S GP+++HCSAG+GR+GTF D L+ +D V
Sbjct: 297 ANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDR---LLQHIRDHEFV 351
Query: 245 DIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274
DI ++ EMR +RM ++QT +Q F + V
Sbjct: 352 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 381
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 179 bits (453), Expect = 6e-45
Identities = 101/270 (37%), Positives = 157/270 (58%), Gaps = 16/270 (5%)
Query: 11 DKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDY 66
D ++ +++++ D P A LP N+ +NRY ++ P+D SR++L +E DY
Sbjct: 94 DSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADY 153
Query: 67 INASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWP 126
INA+ I + + YI TQGPLP T FW+MV +QKS+ +VML + EK +KC YWP
Sbjct: 154 INANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP 213
Query: 127 QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPE 186
EE + + D + + +ISE+ + + R + E ++++HF+YT WPD GVP
Sbjct: 214 FTEE-PIAYGD--ITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPT 268
Query: 187 SPA--SFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSV 244
+ A S L F+ VR+ + S GP+++HCSAG+GR+GTF D L+ +D V
Sbjct: 269 ANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDR---LLQHIRDHEFV 323
Query: 245 DIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274
DI ++ EMR +RM ++QT +Q F + V
Sbjct: 324 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 179 bits (453), Expect = 6e-45
Identities = 101/270 (37%), Positives = 157/270 (58%), Gaps = 16/270 (5%)
Query: 11 DKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDY 66
D ++ +++++ D P A LP N+ +NRY ++ P+D SR++L +E DY
Sbjct: 122 DSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADY 181
Query: 67 INASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWP 126
INA+ I + + YI TQGPLP T FW+MV +QKS+ +VML + EK +KC YWP
Sbjct: 182 INANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP 241
Query: 127 QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPE 186
EE + + D + + +ISE+ + + R + E ++++HF+YT WPD GVP
Sbjct: 242 FTEE-PIAYGD--ITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPT 296
Query: 187 SPA--SFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSV 244
+ A S L F+ VR+ + S GP+++HCSAG+GR+GTF D L+ +D V
Sbjct: 297 ANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDR---LLQHIRDHEFV 351
Query: 245 DIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274
DI ++ EMR +RM ++QT +Q F + V
Sbjct: 352 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,536,968
Number of Sequences: 37866
Number of extensions: 1026674
Number of successful extensions: 7678
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 6642
Number of HSP's gapped (non-prelim): 596
length of query: 435
length of database: 18,247,518
effective HSP length: 105
effective length of query: 330
effective length of database: 14,271,588
effective search space: 4709624040
effective search space used: 4709624040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.