Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4505683
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505683 platelet-derived growth factor receptor beta
precursor [Homo sapiens]
(1106 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505683 platelet-derived growth factor receptor beta precurso... 2225 0.0
gi|5453870 platelet-derived growth factor receptor alpha precurs... 885 0.0
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 504 e-142
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 503 e-142
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 491 e-138
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens] 400 e-111
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 341 3e-93
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 325 1e-88
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 315 2e-85
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 315 2e-85
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 189 1e-47
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 189 1e-47
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 189 1e-47
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 189 1e-47
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 189 1e-47
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 189 1e-47
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 189 1e-47
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 188 2e-47
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 188 2e-47
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 188 2e-47
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 188 2e-47
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 188 2e-47
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 188 2e-47
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 187 5e-47
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 187 5e-47
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 187 5e-47
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 184 5e-46
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 184 5e-46
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 184 5e-46
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 183 9e-46
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 2225 bits (5765), Expect = 0.0
Identities = 1106/1106 (100%), Positives = 1106/1106 (100%)
Query: 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV 60
MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV
Sbjct: 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV 60
Query: 61 VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV 120
VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV
Sbjct: 61 VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV 120
Query: 121 PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS 180
PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS
Sbjct: 121 PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS 180
Query: 181 GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN 240
GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN
Sbjct: 181 GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN 240
Query: 241 EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH 300
EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH
Sbjct: 241 EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH 300
Query: 301 QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS 360
QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS
Sbjct: 301 QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS 360
Query: 361 SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL 420
SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL
Sbjct: 361 SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL 420
Query: 421 ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV 480
ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV
Sbjct: 421 ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV 480
Query: 481 TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA 540
TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA
Sbjct: 481 TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA 540
Query: 541 LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL 600
LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL
Sbjct: 541 LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL 600
Query: 601 VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP 660
VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP
Sbjct: 601 VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP 660
Query: 661 HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL 720
HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL
Sbjct: 661 HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL 720
Query: 721 PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP 780
PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP
Sbjct: 721 PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP 780
Query: 781 SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV 840
SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV
Sbjct: 781 SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV 840
Query: 841 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 900
KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG
Sbjct: 841 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 900
Query: 901 GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER 960
GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER
Sbjct: 901 GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER 960
Query: 961 LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND 1020
LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND
Sbjct: 961 LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND 1020
Query: 1021 YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV 1080
YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV
Sbjct: 1021 YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV 1080
Query: 1081 EPEPELEQLPDSGCPAPRAEAEDSFL 1106
EPEPELEQLPDSGCPAPRAEAEDSFL
Sbjct: 1081 EPEPELEQLPDSGCPAPRAEAEDSFL 1106
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 885 bits (2286), Expect = 0.0
Identities = 488/1084 (45%), Positives = 673/1084 (62%), Gaps = 65/1084 (5%)
Query: 8 PALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWER-MS 66
PA + G LL L+L + + + P E V+ ++S+F L C G + V W+ MS
Sbjct: 6 PAFLVLGCLLTGLSLILCQLSLPS---ILPNENEKVVQLNSSFSLRCFGESEVSWQYPMS 62
Query: 67 QEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ERKRLYIFVP 121
+E ++ + G F +VL +++ + TG Y C +N ++ E + E + +YI+VP
Sbjct: 63 EEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVP 122
Query: 122 DPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSG 181
DP V F+P + + + + IPCR TDP+ VTLH +G V P YD ++GF+G
Sbjct: 123 DPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASYDSRQGFNG 180
Query: 182 IFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENITLMCIVIGN 240
F YIC+ T+ ++ + + VY L+ +S +++ + A++TV + GE I + C V N
Sbjct: 181 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 240
Query: 241 EVVNFEWTYPRKESGR---LVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESV 297
EVV+ +WTYP + G+ ++E + + + Y L +P A ++DSG Y C ++
Sbjct: 241 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVY----TLTVPEATVKDSGDYECAARQAT 296
Query: 298 NDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTL 357
+ ++ K + I+V E G++ + L+ LH + V AYPPP + W K+N TL
Sbjct: 297 REVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTL 356
Query: 358 GDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPV 417
++ EI + E RY S+L L+R K ++GHYT+ A +EDA +F+L VP
Sbjct: 357 IENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPS 415
Query: 418 RVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQL 476
+L+L + H S G QTVRC G P P+I W C+D+K+C E T+L N+ +
Sbjct: 416 SILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN------V 469
Query: 477 ETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVIS 536
+T V + V+ ++VRC +N +G + +E+ +V +L ++ V +
Sbjct: 470 SNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAA 529
Query: 537 AILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELP 596
A+L L+V+ IISLI+L+++W++KPRYEIRW+VIES+S DGHEYIYVDPMQLPYDS WE P
Sbjct: 530 AVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFP 589
Query: 597 RDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMS 656
RD LVLGR LGSGAFG+VVE TA+GLS SQ MKVAVKMLK TARSSEKQALMSELKIM+
Sbjct: 590 RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 649
Query: 657 HLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELY 716
HLGPHLN+VNLLGACTK GPIYIITEYC YGDLV+YLH+N+ +FL HH +K P EL
Sbjct: 650 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELD 706
Query: 717 SNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPY 775
L P S+V L+ E++G YMDM + ++ YVPML+ K KY+DI+ S Y P
Sbjct: 707 IFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPA 766
Query: 776 DNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLI 834
S + + L ++ S L+ +DL+ F+YQVA GMEFLASKNCVHRDLAARNVL+
Sbjct: 767 SYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 826
Query: 835 CEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLW 894
+GK+VKICDFGLARDIM DSNY+SKGSTFLP+KWMAPESIF++LYTTLSDVWS+GILLW
Sbjct: 827 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLW 886
Query: 895 EIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQL 954
EIF+LGGTPYP + ++ FYN IK GYRMA+P HA+ E+YEIM KCW + E RP F L
Sbjct: 887 EIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHL 946
Query: 955 VLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQP 1014
++E LL YKK Y+++ +FL+SDHPA+ R + +D+ +
Sbjct: 947 SEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMR------------VDSDNAYIGVTYK 994
Query: 1015 NE-----------------GDNDYIIPLP--DPKPEVADEGPLEGSPSLAS--STLNEVN 1053
NE D+ YIIPLP DP PE D G S S S + +
Sbjct: 995 NEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGS 1054
Query: 1054 TSST 1057
+SST
Sbjct: 1055 SSST 1058
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 504 bits (1298), Expect = e-142
Identities = 353/993 (35%), Positives = 514/993 (51%), Gaps = 105/993 (10%)
Query: 18 LLSLLLLL-------EPQISQGLVVTP---PGP-ELVLNVSSTFVLTCSGSAPVVWERMS 66
L LLLLL +P +S G P PG +L++ V L C+ V W
Sbjct: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
Query: 67 QEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVG 126
+ E Q+ + TN TG+Y CT+ GL +Y+FV DP
Sbjct: 71 LDETNE--NKQNEWITEKAEATN-----TGKYTCTNK--HGLSNS----IYVFVRDPAKL 117
Query: 127 FLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYD------HQRGFS 180
FL + + ++ E + + C +TDP+ VT + KG P+P D + G
Sbjct: 118 FLVDRS----LYGKEDNDTLVRCPLTDPE--VTNYSLKGCQGKPLPKDLRFIPDPKAGIM 171
Query: 181 GIFEDRSY--ICKTTIGDREVDSDAYYVYRLQVSSIN-----VSVNAVQTVVRQGENITL 233
R+Y +C D+E S + L+V VSV+ ++R+GE T+
Sbjct: 172 IKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTV 231
Query: 234 MCIV--IGNEVVNFEWTYPRKESG-RLVEPVTDFLL-DMPYHIRSILHIPSAELEDSGTY 289
C + + + V + T+ R+ S +L E + D Y ++ L I SA + DSG +
Sbjct: 232 TCTIKDVSSSVYS---TWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVF 288
Query: 290 TCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPT-V 348
C + + VV+ G++ + + T F + L V +EA+P P
Sbjct: 289 MCYANNTFGSAN--VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQ 346
Query: 349 LWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLS 408
W NRT D E + N S RYVSEL L R+K E G YT + D ++
Sbjct: 347 QWIYMNRTFTDK--WEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIA 404
Query: 409 FQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-RCPRELPPTLLG 467
F + +N +L ++ ++C G P+P I W C + RC + P
Sbjct: 405 FNVYVNTKPEIL----TYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPV--- 457
Query: 468 NSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQ------EV 521
++T + + V S++ +V C N VG+ + +
Sbjct: 458 -------DVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKE 510
Query: 522 IVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIY 581
+ PH+L F ++I ++ ++ II ++IL + +KP YE++WKV+E ++ G+ Y+Y
Sbjct: 511 QIHPHTL-FTPLLIGFVIVAGMMCII-VMILTYKYLQKPMYEVQWKVVEEIN--GNNYVY 566
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
+DP QLPYD WE PR++L G+TLG+GAFG+VVEATA+GL S A M VAVKMLK +A
Sbjct: 567 IDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH 626
Query: 642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFL 701
+E++ALMSELK++S+LG H+N+VNLLGACT GGP +ITEYC YGDL+++L R + +F+
Sbjct: 627 LTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI 686
Query: 702 QHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDV 761
S + A LY N L S S +S YMDM V YV + K D
Sbjct: 687 C--SKQEDHAEAALYKNLLH------SKESSCSDSTNEYMDMKP--GVSYV--VPTKAD- 733
Query: 762 KYADIESSNYMAPYDNYVPSAPERTCRATLINESPV-LSYMDLVGFSYQVANGMEFLASK 820
K + +Y+ ER ++ + + L DL+ FSYQVA GM FLASK
Sbjct: 734 KRRSVRIGSYI-----------ERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK 782
Query: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
NC+HRDLAARN+L+ G++ KICDFGLARDI DSNY+ KG+ LP+KWMAPESIFN +Y
Sbjct: 783 NCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVY 842
Query: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
T SDVWS+GI LWE+F+LG +PYP +P++ +FY IK G+RM P HA E+Y+IM+ C
Sbjct: 843 TFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTC 902
Query: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQV 973
W+ RP F Q+V L+E+ + E Y +
Sbjct: 903 WDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 935
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 503 bits (1295), Expect = e-142
Identities = 353/997 (35%), Positives = 514/997 (51%), Gaps = 109/997 (10%)
Query: 18 LLSLLLLL-------EPQISQGLVVTP---PGP-ELVLNVSSTFVLTCSGSAPVVWERMS 66
L LLLLL +P +S G P PG +L++ V L C+ V W
Sbjct: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
Query: 67 QEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVG 126
+ E Q+ + TN TG+Y CT+ GL +Y+FV DP
Sbjct: 71 LDETNE--NKQNEWITEKAEATN-----TGKYTCTNK--HGLSNS----IYVFVRDPAKL 117
Query: 127 FLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYD------HQRGFS 180
FL + + ++ E + + C +TDP+ VT + KG P+P D + G
Sbjct: 118 FLVDRS----LYGKEDNDTLVRCPLTDPE--VTNYSLKGCQGKPLPKDLRFIPDPKAGIM 171
Query: 181 GIFEDRSY--ICKTTIGDREVDSDAYYVYRLQVSSIN-----VSVNAVQTVVRQGENITL 233
R+Y +C D+E S + L+V VSV+ ++R+GE T+
Sbjct: 172 IKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTV 231
Query: 234 MCIV--IGNEVVNFEWTYPRKESG-RLVEPVTDFLL-DMPYHIRSILHIPSAELEDSGTY 289
C + + + V + T+ R+ S +L E + D Y ++ L I SA + DSG +
Sbjct: 232 TCTIKDVSSSVYS---TWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVF 288
Query: 290 TCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPT-V 348
C + + VV+ G++ + + T F + L V +EA+P P
Sbjct: 289 MCYANNTFGSAN--VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQ 346
Query: 349 LWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLS 408
W NRT D E + N S RYVSEL L R+K E G YT + D ++
Sbjct: 347 QWIYMNRTFTDK--WEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIA 404
Query: 409 FQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-RCPRELPPTLLG 467
F + +N +L ++ ++C G P+P I W C + RC + P
Sbjct: 405 FNVYVNTKPEIL----TYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPV--- 457
Query: 468 NSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDT--------- 518
++T + + V S++ +V C N VG+ +
Sbjct: 458 -------DVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKG 510
Query: 519 -QEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGH 577
+ + PH+L F ++I ++ ++ II ++IL + +KP YE++WKV+E ++ G+
Sbjct: 511 NNKEQIHPHTL-FTPLLIGFVIVAGMMCII-VMILTYKYLQKPMYEVQWKVVEEIN--GN 566
Query: 578 EYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK 637
Y+Y+DP QLPYD WE PR++L G+TLG+GAFG+VVEATA+GL S A M VAVKMLK
Sbjct: 567 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 626
Query: 638 STARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNK 697
+A +E++ALMSELK++S+LG H+N+VNLLGACT GGP +ITEYC YGDL+++L R +
Sbjct: 627 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 686
Query: 698 HTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDM 757
+F+ S + A LY N L S S +S YMDM V YV +
Sbjct: 687 DSFIC--SKQEDHAEAALYKNLLH------SKESSCSDSTNEYMDMKP--GVSYV--VPT 734
Query: 758 KGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPV-LSYMDLVGFSYQVANGMEF 816
K D K + +Y+ ER ++ + + L DL+ FSYQVA GM F
Sbjct: 735 KAD-KRRSVRIGSYI-----------ERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAF 782
Query: 817 LASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIF 876
LASKNC+HRDLAARN+L+ G++ KICDFGLARDI DSNY+ KG+ LP+KWMAPESIF
Sbjct: 783 LASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIF 842
Query: 877 NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEI 936
N +YT SDVWS+GI LWE+F+LG +PYP +P++ +FY IK G+RM P HA E+Y+I
Sbjct: 843 NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 902
Query: 937 MQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQV 973
M+ CW+ RP F Q+V L+E+ + E Y +
Sbjct: 903 MKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 491 bits (1265), Expect = e-138
Identities = 346/984 (35%), Positives = 497/984 (50%), Gaps = 99/984 (10%)
Query: 18 LLSLLLLLEPQISQGL-VVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKA 76
+L LLL+ QG+ V+ P PELV+ +T L C G+ V W+ P
Sbjct: 5 VLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDG---PPSPHWTLY 61
Query: 77 QDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELF 136
DG+ SS+L+ N T +TG Y CT G ++++V DP + A+E+
Sbjct: 62 SDGS-SSILSTNNATFQNTGTYRCTEP---GDPLGGSAAIHLYVKDPARPWNVL-AQEVV 116
Query: 137 IFLTEITEITIPCRVTDPQLV--VTLHEKKGDVALP---VPYDHQRGFS----GIFEDRS 187
+F E + +PC +TDP L V+L +G + + GF+ + +
Sbjct: 117 VF--EDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQD 174
Query: 188 YICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQ-----GENITLMCIVIGNEV 242
Y C +G R+V S + RL+V + A+ V + GE ++C +V
Sbjct: 175 YQCSALMGGRKVMSISI---RLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDV 231
Query: 243 VNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQD 302
NF+ + + + +L P + Y L++ + + +G Y+C + H
Sbjct: 232 -NFD-VFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHST 289
Query: 303 EKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSA 362
++ VVES Y+ L E +Q + L+V+ EAYP + D
Sbjct: 290 --SMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQP 347
Query: 363 GEIALSTRNVSET-RYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLE 421
E L+ +T R+ L+L R+K +EAG Y+ A + L+F+L + P V
Sbjct: 348 -EPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSV 406
Query: 422 LSESHPDSGEQTVRCRGRGMPQPNIIWSACRD-LKRCPRELPPTLLGNSSEEESQLETNV 480
+ SG T+ C G PQPN+ W C RC + + E V
Sbjct: 407 IWTFINGSG--TLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPE-------V 457
Query: 481 TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVV--------PHSLPFKV 532
E + V S L ++ ++ + C N+VG + I + P F
Sbjct: 458 LSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTP 517
Query: 533 VVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDST 592
VV+ A ++++ L ++ L++L+ +++KP+Y++RWK+IES +G+ Y ++DP QLPY+
Sbjct: 518 VVV-ACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESY--EGNSYTFIDPTQLPYNEK 574
Query: 593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSEL 652
WE PR+ L G+TLG+GAFG+VVEATA GL A +KVAVKMLKSTA + EK+ALMSEL
Sbjct: 575 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 634
Query: 653 KIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPS 712
KIMSHLG H N+VNLLGACT GGP+ +ITEYC YGDL+++L R L + P
Sbjct: 635 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDP- 693
Query: 713 AELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYM 772
+GG VDY ++ + KY +S
Sbjct: 694 ------------------------EGG---------VDYK---NIHLEKKYVRRDSGFSS 717
Query: 773 APYDNYVPSAPERTCRATLINESPV-------LSYMDLVGFSYQVANGMEFLASKNCVHR 825
D YV P T +E + L DL+ FS QVA GM FLASKNC+HR
Sbjct: 718 QGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR 777
Query: 826 DLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSD 885
D+AARNVL+ G + KI DFGLARDIM DSNYI KG+ LP+KWMAPESIF+ +YT SD
Sbjct: 778 DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD 837
Query: 886 VWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKF 945
VWS+GILLWEIF+LG PYP + +N +FY +K GY+MAQPA A IY IMQ CW +
Sbjct: 838 VWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEP 897
Query: 946 EIRPPFSQLVLLLERLLGEGYKKK 969
RP F Q+ L+ E +++
Sbjct: 898 THRPTFQQICSFLQEQAQEDRRER 921
>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
Length = 993
Score = 400 bits (1027), Expect = e-111
Identities = 253/710 (35%), Positives = 365/710 (51%), Gaps = 64/710 (9%)
Query: 278 IPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQ 337
+ S D+G YTC S + H + A+ +T+VE G++ + + +
Sbjct: 317 VSSVARNDTGYYTC----SSSKHPSQSAL-VTIVEKGFINATNSSEDYEIDQ-YEEFCFS 370
Query: 338 VVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMR 397
V F+AYP W ++ G S +++ + + G Y
Sbjct: 371 VRFKAYPQIRCTWTFSRKSFPCEQKG----LDNGYSISKFCNHKH-------QPGEYIFH 419
Query: 398 AFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-R 456
A ++DA+ F L I +VL ++ C G P P+ W C D
Sbjct: 420 AENDDAQFTKMFTLNIRRKPQVLA------EASASQASCFSDGYPLPSWTWKKCSDKSPN 473
Query: 457 CPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQ 516
C E+ + + + W STL + + V+C N++G
Sbjct: 474 CTEEITEGVWNRKANRKV-----FGQWVSS------STLNMSEAIKGFLVKCCAYNSLGT 522
Query: 517 DTQEVIV-VPHSLPFKVVVIS--AILALVVLTIISLIILIM-LWQKKPRYEIRWKVIESV 572
+ +++ P PF IS A + + +L I+ L +LI ++K+ RYE + ++++
Sbjct: 523 SCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVT 582
Query: 573 SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVA 632
S +EY YVD + YD WE PR+ L G+ LGSGAFG+V+ ATA+G+S + +++VA
Sbjct: 583 GSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVA 642
Query: 633 VKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDY 692
VKMLK A SSE++ALMSELK+M+ LG H N+VNLLGACT GPIY+I EYC YGDL++Y
Sbjct: 643 VKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNY 702
Query: 693 LHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYV 752
L + F + ++ + + Y P+ S S G ++ D +
Sbjct: 703 LRSKREKFHRTWTEIFKEHNFSFY----------PTFQSHPNSSMPGSREVQIHPDSDQI 752
Query: 753 PMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVAN 812
L +IE Y+N E + VL++ DL+ F+YQVA
Sbjct: 753 SGLHGNSFHSEDEIE-------YENQKRLEEE--------EDLNVLTFEDLLCFAYQVAK 797
Query: 813 GMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAP 872
GMEFL K+CVHRDLAARNVL+ GK+VKICDFGLARDIM DSNY+ +G+ LP+KWMAP
Sbjct: 798 GMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAP 857
Query: 873 ESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDE 932
ES+F +YT SDVWS+GILLWEIF+LG PYP +P++ FY I+ G++M QP +A++E
Sbjct: 858 ESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEE 917
Query: 933 IYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDH 982
IY IMQ CW RP F L L L + + YQ VD H
Sbjct: 918 IYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPH 967
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 341 bits (874), Expect = 3e-93
Identities = 243/717 (33%), Positives = 369/717 (51%), Gaps = 66/717 (9%)
Query: 255 GRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESG 314
G +E +T + + + + A+ SG Y C + V + IT V +G
Sbjct: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
Query: 315 YVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSE 374
+ L ++ T + +L S T+ +L +NRT+ S + + T+ S
Sbjct: 559 FHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
Query: 375 TRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINV-----PVRVLELSE-SHPD 428
T LT++ V + ++G Y RA + ++ + +I + P + LS+ +
Sbjct: 618 TL---NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI 674
Query: 429 SGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQE 488
S T+ C G+P+P I W ++ + +E P +LG S S L E+E
Sbjct: 675 SSSTTLDCHANGVPEPQITWF--KNNHKIQQE-PGIILGPGS---STLFIERVTEEDEGV 728
Query: 489 FEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIIS 548
+ +T + V+ S T++ + E+I + ++A L ++LT
Sbjct: 729 YHCKATNQKGSVES--SAYLTVQGTSDKSNLELITLT------CTCVAATLFWLLLT--- 777
Query: 549 LIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLG 607
L + K+ EI+ + + + +LPYD S WE R++L LG++LG
Sbjct: 778 ---LFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLG 834
Query: 608 SGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNL 667
GAFG+VV+A+A G+ S VAVKMLK A +SE +ALM+ELKI++H+G HLNVVNL
Sbjct: 835 RGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNL 894
Query: 668 LGACTK-GGPIYIITEYCRYGDLVDYLHRNKHTF-LQHHSDKRRPPSAELYSNALPVGLP 725
LGACTK GGP+ +I EYC+YG+L +YL + F L + P E L G
Sbjct: 895 LGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKK 954
Query: 726 LPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPER 785
P S+T +D+S+ DV+ + Y P
Sbjct: 955 -PRLDSVTSSESFASSGFQEDKSLS---------DVEEEEDSDGFYKEP----------- 993
Query: 786 TCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDF 845
++ DL+ +S+QVA GMEFL+S+ C+HRDLAARN+L+ E +VKICDF
Sbjct: 994 ------------ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDF 1041
Query: 846 GLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYP 905
GLARDI ++ +Y+ KG T LPLKWMAPESIF+ +Y+T SDVWS+G+LLWEIF+LGG+PYP
Sbjct: 1042 GLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYP 1101
Query: 906 ELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
+ M+E F + ++ G RM P +++ EIY+IM CW + RP F++LV L LL
Sbjct: 1102 GVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
Score = 108 bits (269), Expect = 4e-23
Identities = 127/478 (26%), Positives = 205/478 (42%), Gaps = 62/478 (12%)
Query: 14 GELLLLSLLLLLEPQISQGLVVTPP-----GPELVLNVSSTFVLTCSGSAPVVW---ERM 65
G LL L LL S G + P G + ++ T L C G A W E +
Sbjct: 8 GVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMV 67
Query: 66 SQEPPQ----EMAKAQDGT-FSSVLTLTNLTGLDTGEYFCTH---NDSRGLETDERKRLY 117
S+E + + A ++G F S LTL TG Y C + S+ ET+ +Y
Sbjct: 68 SKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESA--IY 125
Query: 118 IFVPDPTVGFLPNDAE-ELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALP----VP 172
IF+ D F+ +E I +TE E+ IPCRVT P + VTL + D +P +
Sbjct: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRII 185
Query: 173 YDHQRGFSGIFEDRSY------ICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTV-V 225
+D ++GF I + +Y C+ T+ ++ Y +R + I+V ++ + V +
Sbjct: 186 WDSRKGF--IISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPRPVKL 242
Query: 226 RQGENITLMCIVIG--NEVVNFEWTYPRKESGRL-VEPVTDFLLDMPYHIRSILHIPSAE 282
+G + L C N V W+YP +++ R V D S+L I +
Sbjct: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
Query: 283 LEDSGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLL-GEVGTLQFAELHRSRTLQVV 339
+D G YTC V K++N + + + ++ + + L+ RS L +
Sbjct: 303 NKDKGLYTCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMK 358
Query: 340 FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAF 399
+A+P P V+W KD + SA + TR S L + V +AG+YT+
Sbjct: 359 VKAFPSPEVVWLKDGLPATEKSARYL---TRGYS-------LIIKDVTEEDAGNYTILLS 408
Query: 400 HEDAEV--QLSFQLQINVPVRVLELSES-------HPDSGEQTVRCRGRGMPQPNIIW 448
+ + V L+ L +NV ++ E + S +P Q + C G+PQP I W
Sbjct: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 325 bits (833), Expect = 1e-88
Identities = 202/533 (37%), Positives = 288/533 (54%), Gaps = 58/533 (10%)
Query: 434 VRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVS 493
V C G P P I+W + TL+ +S N+T +E E +
Sbjct: 686 VSCTASGNPPPQIMWFKDNE----------TLVEDSGIVLKDGNRNLTIRRVRKEDEGLY 735
Query: 494 TLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILI 553
T + V V Q+ + ++ ++V +A++A+ + L+I++
Sbjct: 736 TCQACSVLGCAKVEAFFIIEGAQEKTNLEII-------ILVGTAVIAMFFWLL--LVIIL 786
Query: 554 MLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLGSGAFG 612
++ E++ + V + +LPYD S WE PRD+L LG+ LG GAFG
Sbjct: 787 RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFG 846
Query: 613 QVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
QV+EA A G+ + VAVKMLK A SE +ALMSELKI+ H+G HLNVVNLLGACT
Sbjct: 847 QVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT 906
Query: 673 K-GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLP--LPSH 729
K GGP+ +I E+C++G+L YL ++ F+ + + R + Y A+PV L L S
Sbjct: 907 KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSI 966
Query: 730 VSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRA 789
S + G+++ + +D+E AP D Y
Sbjct: 967 TSSQSSASSGFVE-----------------EKSLSDVEEEE--APEDLY----------- 996
Query: 790 TLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR 849
L+ L+ +S+QVA GMEFLAS+ C+HRDLAARN+L+ E +VKICDFGLAR
Sbjct: 997 -----KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR 1051
Query: 850 DIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPM 909
DI +D +Y+ KG LPLKWMAPE+IF+ +YT SDVWSFG+LLWEIF+LG +PYP + +
Sbjct: 1052 DIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 1111
Query: 910 NEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
+E+F +K G RM P + + E+Y+ M CW + RP FS+LV L LL
Sbjct: 1112 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164
Score = 86.7 bits (213), Expect = 1e-16
Identities = 115/518 (22%), Positives = 210/518 (40%), Gaps = 63/518 (12%)
Query: 42 LVLNVSSTFVLTCSGSAPVVW----ERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGE 97
L + ++T +TC G + W + E E+ + DG F LT+ + G DTG
Sbjct: 41 LTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGA 100
Query: 98 YFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEE---LFIFLTEITEITIPCRVTDP 154
Y C + ETD +Y++V D F+ + +++ ++I + + IPC +
Sbjct: 101 YKCFYR-----ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSIS 155
Query: 155 QLVVTLHEKKGDVAL-----PVPYDHQRGFSGIFEDRSY----ICKTTIGDREVDSDAYY 205
L V+L + + + +D ++GF+ SY C+ I D S Y
Sbjct: 156 NLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYI 215
Query: 206 VYRLQVSSINVSVNAVQTV-VRQGENITLMCIVIG--NEVVNFEWTYP--RKESGRLV-- 258
V + +V ++ + + GE + L C N ++F W YP + + +LV
Sbjct: 216 VVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNR 275
Query: 259 EPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRL 318
+ T +M + S L I D G YTC + + ++ + V E +V
Sbjct: 276 DLKTQSGSEMKKFL-STLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVR--VHEKPFVAF 332
Query: 319 LGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYV 378
+ +L A + + + YPPP + W+K+ I L + + + +V
Sbjct: 333 GSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNG----------IPLESNHTIKAGHV 382
Query: 379 SELTLVRVKVAEAGHYTMRAFHEDAEVQLS--FQLQINVPVRVLELS-----ESHPDSGE 431
LT++ V + G+YT+ + ++ + S L + VP ++ E S +S+
Sbjct: 383 --LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTT 440
Query: 432 QTVRCRGRGMPQPNII---WSACRDLKRCPRELPPTLLGNSSEE---------ESQLETN 479
QT+ C +P P+ I W + P + EE +++E N
Sbjct: 441 QTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVN 500
Query: 480 VTYWE-EEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQ 516
+ E + + VSTL +Q + +C N VG+
Sbjct: 501 KNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGR 538
Score = 50.4 bits (119), Expect = 9e-06
Identities = 34/124 (27%), Positives = 54/124 (43%), Gaps = 10/124 (8%)
Query: 275 ILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR 334
I+ + +A L+D G Y C + + +TV+E + G + Q + S
Sbjct: 626 IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN-QTTSIGESI 684
Query: 335 TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHY 394
+ PPP ++WFKDN TL + S + RN LT+ RV+ + G Y
Sbjct: 685 EVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRN---------LTIRRVRKEDEGLY 735
Query: 395 TMRA 398
T +A
Sbjct: 736 TCQA 739
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 315 bits (807), Expect = 2e-85
Identities = 234/715 (32%), Positives = 353/715 (49%), Gaps = 93/715 (13%)
Query: 286 SGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEA- 342
S Y C V+ V QDE+ I +T + G+ + + EL + + + +A
Sbjct: 529 SAMYKCVVSNKVG--QDERLIYFYVTTIPDGFT-----IESKPSEELLEGQPVLLSCQAD 581
Query: 343 -YPPPTVLWFKDN-RTLGDSSAGEIALSTRNVS---------------ETRYVS-ELTLV 384
Y + W++ N TL D+ + L +NV R+ + L++
Sbjct: 582 SYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIP 641
Query: 385 RVKVAEAGHYTMRAFHEDAEVQLSFQLQINVP-VRVLELSESHPD-----SGEQTVRCRG 438
RV GHY + + + ++V + L+++ D S ++C
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
Query: 439 RGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQ 498
G P+I+W +D +R E L +S+++ S + +R +
Sbjct: 702 AGAHAPSIVWY--KD-ERLLEEKSGVDLADSNQKLS-----------------IQRVREE 741
Query: 499 HVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQK 558
R L C + V + +VI ++ + L++LI +
Sbjct: 742 DAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801
Query: 559 KPRY-EIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLGSGAFGQVVE 616
+P + +I+ + + G + L YD S WE PR++L LGR LG GAFG+VVE
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 617 ATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG-G 675
A+A G+ + VAVKMLK A +SE +ALMSELKI+ H+G HLNVVNLLGACTK G
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQG 921
Query: 676 PIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGE 735
P+ +I E+C+YG+L ++L + F P AE + E
Sbjct: 922 PLMVIVEFCKYGNLSNFLRAKRDAF---------SPCAEK-----------------SPE 955
Query: 736 SDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES 795
G + M + + LD + + + + ++P++ ++
Sbjct: 956 QRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP- 1008
Query: 796 PVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS 855
L+ DLV +S+QVA GMEFLAS+ C+HRDLAARN+L+ E +VKICDFGLARDI +D
Sbjct: 1009 --LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDP 1066
Query: 856 NYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYN 915
+Y+ KGS LPLKWMAPESIF+ +YTT SDVWSFG+LLWEIF+LG +PYP + +NE+F
Sbjct: 1067 DYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQ 1126
Query: 916 AIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL-GEGYKKK 969
++ G RM P A+ I IM CW + RP FS+LV +L LL G G +++
Sbjct: 1127 RLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
Score = 111 bits (277), Expect = 4e-24
Identities = 140/574 (24%), Positives = 240/574 (41%), Gaps = 78/574 (13%)
Query: 13 KGELLLLSLLL---LLEPQISQGLVVTPPGPEL-----VLNVSSTFVLTCSGSAPVVWER 64
+G L L L L LL+ +S G +TPP + V++ + ++C G P+ W
Sbjct: 3 RGAALCLRLWLCLGLLDGLVS-GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAW 61
Query: 65 M-SQEPPQEMAKAQDGT-------------FSSVLTLTNLTGLDTGEYFCTHNDSRG-LE 109
+QE P K + T + VL L + DTG Y C + + +E
Sbjct: 62 PGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIE 121
Query: 110 TDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDV-- 167
Y+FV D F+ N + L + + + +PC V+ P L VTL + +
Sbjct: 122 GTTAASSYVFVRDFEQPFI-NKPDTLLVNRKDA--MWVPCLVSIPGLNVTLRSQSSVLWP 178
Query: 168 -ALPVPYDHQRGF---SGIFEDRSYI-CKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQ 222
V +D +RG + + D Y+ C+TT GD++ S+ + V+ ++ + +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 223 TV-VRQGENITLMCIVIG--NEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIP 279
++ + GE + L C V N V F+W YP K++ R + SIL I
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIH 298
Query: 280 SAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRT-LQV 338
+ D G+Y C + ++ + + V E+ ++ + G + A L V
Sbjct: 299 NVSQHDLGSYVCKANNGIQRFRE--STEVIVHENPFISVEWLKGPILEATAGDELVKLPV 356
Query: 339 VFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRA 398
AYPPP W+KD + ALS R+ L L V A G YT+
Sbjct: 357 KLAAYPPPEFQWYKDGK----------ALSGRHSPHA-----LVLKEVTEASTGTYTLAL 401
Query: 399 FHEDAEVQ--LSFQLQINVPVRVLELSESHPD----SGEQTVRCRGRGMPQPNII----- 447
++ A ++ +S +L +NVP ++ E S P Q + C G+P P I
Sbjct: 402 WNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWR 461
Query: 448 -WSACRDL------KRCPRELPPTLLG----NSSEEESQLETNVTYWE-EEQEFEVVSTL 495
W+ C+ +R ++L P + + + +E+ T+ E E + + VS L
Sbjct: 462 PWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKL 521
Query: 496 RLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLP 529
+Q+ + +C + N VGQD + + ++P
Sbjct: 522 VIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIP 555
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 315 bits (807), Expect = 2e-85
Identities = 234/715 (32%), Positives = 353/715 (49%), Gaps = 93/715 (13%)
Query: 286 SGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEA- 342
S Y C V+ V QDE+ I +T + G+ + + EL + + + +A
Sbjct: 529 SAMYKCVVSNKVG--QDERLIYFYVTTIPDGFT-----IESKPSEELLEGQPVLLSCQAD 581
Query: 343 -YPPPTVLWFKDN-RTLGDSSAGEIALSTRNVS---------------ETRYVS-ELTLV 384
Y + W++ N TL D+ + L +NV R+ + L++
Sbjct: 582 SYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIP 641
Query: 385 RVKVAEAGHYTMRAFHEDAEVQLSFQLQINVP-VRVLELSESHPD-----SGEQTVRCRG 438
RV GHY + + + ++V + L+++ D S ++C
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
Query: 439 RGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQ 498
G P+I+W +D +R E L +S+++ S + +R +
Sbjct: 702 AGAHAPSIVWY--KD-ERLLEEKSGVDLADSNQKLS-----------------IQRVREE 741
Query: 499 HVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQK 558
R L C + V + +VI ++ + L++LI +
Sbjct: 742 DAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMR 801
Query: 559 KPRY-EIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLGSGAFGQVVE 616
+P + +I+ + + G + L YD S WE PR++L LGR LG GAFG+VVE
Sbjct: 802 RPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVE 861
Query: 617 ATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG-G 675
A+A G+ + VAVKMLK A +SE +ALMSELKI+ H+G HLNVVNLLGACTK G
Sbjct: 862 ASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQG 921
Query: 676 PIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGE 735
P+ +I E+C+YG+L ++L + F P AE + E
Sbjct: 922 PLMVIVEFCKYGNLSNFLRAKRDAF---------SPCAEK-----------------SPE 955
Query: 736 SDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES 795
G + M + + LD + + + + ++P++ ++
Sbjct: 956 QRGRFRAMVE------LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP- 1008
Query: 796 PVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS 855
L+ DLV +S+QVA GMEFLAS+ C+HRDLAARN+L+ E +VKICDFGLARDI +D
Sbjct: 1009 --LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDP 1066
Query: 856 NYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYN 915
+Y+ KGS LPLKWMAPESIF+ +YTT SDVWSFG+LLWEIF+LG +PYP + +NE+F
Sbjct: 1067 DYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQ 1126
Query: 916 AIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL-GEGYKKK 969
++ G RM P A+ I IM CW + RP FS+LV +L LL G G +++
Sbjct: 1127 RLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
Score = 111 bits (277), Expect = 4e-24
Identities = 140/574 (24%), Positives = 240/574 (41%), Gaps = 78/574 (13%)
Query: 13 KGELLLLSLLL---LLEPQISQGLVVTPPGPEL-----VLNVSSTFVLTCSGSAPVVWER 64
+G L L L L LL+ +S G +TPP + V++ + ++C G P+ W
Sbjct: 3 RGAALCLRLWLCLGLLDGLVS-GYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAW 61
Query: 65 M-SQEPPQEMAKAQDGT-------------FSSVLTLTNLTGLDTGEYFCTHNDSRG-LE 109
+QE P K + T + VL L + DTG Y C + + +E
Sbjct: 62 PGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIE 121
Query: 110 TDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDV-- 167
Y+FV D F+ N + L + + + +PC V+ P L VTL + +
Sbjct: 122 GTTAASSYVFVRDFEQPFI-NKPDTLLVNRKDA--MWVPCLVSIPGLNVTLRSQSSVLWP 178
Query: 168 -ALPVPYDHQRGF---SGIFEDRSYI-CKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQ 222
V +D +RG + + D Y+ C+TT GD++ S+ + V+ ++ + +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 223 TV-VRQGENITLMCIVIG--NEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIP 279
++ + GE + L C V N V F+W YP K++ R + SIL I
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIH 298
Query: 280 SAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRT-LQV 338
+ D G+Y C + ++ + + V E+ ++ + G + A L V
Sbjct: 299 NVSQHDLGSYVCKANNGIQRFRE--STEVIVHENPFISVEWLKGPILEATAGDELVKLPV 356
Query: 339 VFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRA 398
AYPPP W+KD + ALS R+ L L V A G YT+
Sbjct: 357 KLAAYPPPEFQWYKDGK----------ALSGRHSPHA-----LVLKEVTEASTGTYTLAL 401
Query: 399 FHEDAEVQ--LSFQLQINVPVRVLELSESHPD----SGEQTVRCRGRGMPQPNII----- 447
++ A ++ +S +L +NVP ++ E S P Q + C G+P P I
Sbjct: 402 WNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWR 461
Query: 448 -WSACRDL------KRCPRELPPTLLG----NSSEEESQLETNVTYWE-EEQEFEVVSTL 495
W+ C+ +R ++L P + + + +E+ T+ E E + + VS L
Sbjct: 462 PWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKL 521
Query: 496 RLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLP 529
+Q+ + +C + N VGQD + + ++P
Sbjct: 522 VIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIP 555
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 189 bits (481), Expect = 1e-47
Identities = 92/178 (51%), Positives = 125/178 (70%), Gaps = 1/178 (0%)
Query: 793 NESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM 852
N LS DLV +YQVA GME+LASK C+HRDLAARNVL+ E ++KI DFGLARDI
Sbjct: 499 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 558
Query: 853 RDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ 912
Y + LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+
Sbjct: 559 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV-EE 617
Query: 913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKY 970
+ +K G+RM +P++ ++E+Y +M+ CW RP F QLV L+R++ ++Y
Sbjct: 618 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY 675
Score = 122 bits (306), Expect = 2e-27
Identities = 65/141 (46%), Positives = 87/141 (61%), Gaps = 2/141 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATM--KVAVKMLKST 639
V +LP D WELPRD+LVLG+ LG G FGQVV A A GL + KVAVKMLKS
Sbjct: 369 VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 428
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 429 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 488
Query: 700 FLQHHSDKRRPPSAELYSNAL 720
L++ + P +L S L
Sbjct: 489 GLEYCYNPSHNPEEQLSSKDL 509
Score = 30.4 bits (67), Expect = 9.7
Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 18/86 (20%)
Query: 225 VRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPY-------------H 271
V G N+ MC V + + +W + +G + P ++PY
Sbjct: 176 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD-----NLPYVQILKTAGVNTTDK 230
Query: 272 IRSILHIPSAELEDSGTYTCNVTESV 297
+LH+ + ED+G YTC S+
Sbjct: 231 EMEVLHLRNVSFEDAGEYTCLAGNSI 256
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 189 bits (481), Expect = 1e-47
Identities = 92/178 (51%), Positives = 125/178 (70%), Gaps = 1/178 (0%)
Query: 793 NESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM 852
N LS DLV +YQVA GME+LASK C+HRDLAARNVL+ E ++KI DFGLARDI
Sbjct: 501 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 560
Query: 853 RDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ 912
Y + LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+
Sbjct: 561 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV-EE 619
Query: 913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKY 970
+ +K G+RM +P++ ++E+Y +M+ CW RP F QLV L+R++ ++Y
Sbjct: 620 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY 677
Score = 122 bits (306), Expect = 2e-27
Identities = 65/141 (46%), Positives = 87/141 (61%), Gaps = 2/141 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATM--KVAVKMLKST 639
V +LP D WELPRD+LVLG+ LG G FGQVV A A GL + KVAVKMLKS
Sbjct: 371 VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 430
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 431 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 490
Query: 700 FLQHHSDKRRPPSAELYSNAL 720
L++ + P +L S L
Sbjct: 491 GLEYCYNPSHNPEEQLSSKDL 511
Score = 30.4 bits (67), Expect = 9.7
Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 18/86 (20%)
Query: 225 VRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPY-------------H 271
V G N+ MC V + + +W + +G + P ++PY
Sbjct: 178 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD-----NLPYVQILKTAGVNTTDK 232
Query: 272 IRSILHIPSAELEDSGTYTCNVTESV 297
+LH+ + ED+G YTC S+
Sbjct: 233 EMEVLHLRNVSFEDAGEYTCLAGNSI 258
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 189 bits (481), Expect = 1e-47
Identities = 92/178 (51%), Positives = 125/178 (70%), Gaps = 1/178 (0%)
Query: 793 NESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM 852
N LS DLV +YQVA GME+LASK C+HRDLAARNVL+ E ++KI DFGLARDI
Sbjct: 588 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 647
Query: 853 RDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ 912
Y + LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+
Sbjct: 648 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV-EE 706
Query: 913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKY 970
+ +K G+RM +P++ ++E+Y +M+ CW RP F QLV L+R++ ++Y
Sbjct: 707 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY 764
Score = 122 bits (306), Expect = 2e-27
Identities = 65/141 (46%), Positives = 87/141 (61%), Gaps = 2/141 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATM--KVAVKMLKST 639
V +LP D WELPRD+LVLG+ LG G FGQVV A A GL + KVAVKMLKS
Sbjct: 458 VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 517
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 518 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 577
Query: 700 FLQHHSDKRRPPSAELYSNAL 720
L++ + P +L S L
Sbjct: 578 GLEYCYNPSHNPEEQLSSKDL 598
Score = 30.4 bits (67), Expect = 9.7
Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 18/86 (20%)
Query: 225 VRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPY-------------H 271
V G N+ MC V + + +W + +G + P ++PY
Sbjct: 265 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD-----NLPYVQILKTAGVNTTDK 319
Query: 272 IRSILHIPSAELEDSGTYTCNVTESV 297
+LH+ + ED+G YTC S+
Sbjct: 320 EMEVLHLRNVSFEDAGEYTCLAGNSI 345
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 189 bits (481), Expect = 1e-47
Identities = 92/178 (51%), Positives = 125/178 (70%), Gaps = 1/178 (0%)
Query: 793 NESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM 852
N LS DLV +YQVA GME+LASK C+HRDLAARNVL+ E ++KI DFGLARDI
Sbjct: 590 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 649
Query: 853 RDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ 912
Y + LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+
Sbjct: 650 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV-EE 708
Query: 913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKY 970
+ +K G+RM +P++ ++E+Y +M+ CW RP F QLV L+R++ ++Y
Sbjct: 709 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY 766
Score = 122 bits (306), Expect = 2e-27
Identities = 65/141 (46%), Positives = 87/141 (61%), Gaps = 2/141 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATM--KVAVKMLKST 639
V +LP D WELPRD+LVLG+ LG G FGQVV A A GL + KVAVKMLKS
Sbjct: 460 VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 519
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 520 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 579
Query: 700 FLQHHSDKRRPPSAELYSNAL 720
L++ + P +L S L
Sbjct: 580 GLEYCYNPSHNPEEQLSSKDL 600
Score = 30.4 bits (67), Expect = 9.7
Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 18/86 (20%)
Query: 225 VRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPY-------------H 271
V G N+ MC V + + +W + +G + P ++PY
Sbjct: 267 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD-----NLPYVQILKTAGVNTTDK 321
Query: 272 IRSILHIPSAELEDSGTYTCNVTESV 297
+LH+ + ED+G YTC S+
Sbjct: 322 EMEVLHLRNVSFEDAGEYTCLAGNSI 347
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 189 bits (480), Expect = 1e-47
Identities = 91/180 (50%), Positives = 126/180 (70%), Gaps = 1/180 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
L++ DLV +YQVA GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARD+ Y
Sbjct: 591 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 650
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+ + +
Sbjct: 651 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV-EELFKLL 709
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ + ++Y IM++CW RP F QLV L+R+L +Y + F
Sbjct: 710 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPF 769
Score = 120 bits (301), Expect = 7e-27
Identities = 61/145 (42%), Positives = 88/145 (60%), Gaps = 2/145 (1%)
Query: 573 SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQAT--MK 630
S +G V ++LP D WEL R +L LG+ LG G FGQVV A A G+ +A +
Sbjct: 447 SGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT 506
Query: 631 VAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 690
VAVKMLK A + L+SE+++M +G H N++NLLGACT+GGP+Y++ EY G+L
Sbjct: 507 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR 566
Query: 691 DYLHRNKHTFLQHHSDKRRPPSAEL 715
++L + L + D +PP +L
Sbjct: 567 EFLRARRPPGLDYSFDTCKPPEEQL 591
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 189 bits (480), Expect = 1e-47
Identities = 91/180 (50%), Positives = 126/180 (70%), Gaps = 1/180 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
L++ DLV +YQVA GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARD+ Y
Sbjct: 477 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 536
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+ + +
Sbjct: 537 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV-EELFKLL 595
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ + ++Y IM++CW RP F QLV L+R+L +Y + F
Sbjct: 596 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPF 655
Score = 120 bits (301), Expect = 7e-27
Identities = 61/145 (42%), Positives = 88/145 (60%), Gaps = 2/145 (1%)
Query: 573 SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQAT--MK 630
S +G V ++LP D WEL R +L LG+ LG G FGQVV A A G+ +A +
Sbjct: 333 SGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT 392
Query: 631 VAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 690
VAVKMLK A + L+SE+++M +G H N++NLLGACT+GGP+Y++ EY G+L
Sbjct: 393 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR 452
Query: 691 DYLHRNKHTFLQHHSDKRRPPSAEL 715
++L + L + D +PP +L
Sbjct: 453 EFLRARRPPGLDYSFDTCKPPEEQL 477
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 189 bits (480), Expect = 1e-47
Identities = 91/180 (50%), Positives = 126/180 (70%), Gaps = 1/180 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
L++ DLV +YQVA GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARD+ Y
Sbjct: 589 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 648
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+LLWEIFTLGG+PYP +P+ E+ + +
Sbjct: 649 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV-EELFKLL 707
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ + ++Y IM++CW RP F QLV L+R+L +Y + F
Sbjct: 708 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPF 767
Score = 120 bits (301), Expect = 7e-27
Identities = 61/145 (42%), Positives = 88/145 (60%), Gaps = 2/145 (1%)
Query: 573 SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQAT--MK 630
S +G V ++LP D WEL R +L LG+ LG G FGQVV A A G+ +A +
Sbjct: 445 SGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT 504
Query: 631 VAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 690
VAVKMLK A + L+SE+++M +G H N++NLLGACT+GGP+Y++ EY G+L
Sbjct: 505 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR 564
Query: 691 DYLHRNKHTFLQHHSDKRRPPSAEL 715
++L + L + D +PP +L
Sbjct: 565 EFLRARRPPGLDYSFDTCKPPEEQL 589
Score = 30.8 bits (68), Expect = 7.4
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 26/88 (29%)
Query: 84 VLTLTNLTGLDTGEYFCTHNDSRG-----------------LETDERKRLYIFVPDPTVG 126
VL+L N+T D GEY C +S G +E DE +Y + VG
Sbjct: 323 VLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVG 382
Query: 127 FLPNDAEELFIFLTEITEITIPCRVTDP 154
F F+F+ + +T+ CR+ P
Sbjct: 383 F--------FLFILVVAAVTL-CRLRSP 401
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 481 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 540
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 541 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 599
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 600 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 652
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 653 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 346 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 405
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 406 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 465
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 466 GMEYSYDINRVPEEQM 481
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 542 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 600
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 653
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 654 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 688
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 347 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 406
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 407 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 466
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 467 GMEYSYDINRVPEEQM 482
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 483 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 542
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 543 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 601
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 602 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 654
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 655 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 348 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 407
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 408 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 467
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 468 GMEYSYDINRVPEEQM 483
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 486 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 546 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 604
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 605 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 657
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 658 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 692
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 351 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 410
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 411 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 470
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 471 GMEYSYDINRVPEEQM 486
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 598 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 657
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 658 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 716
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 717 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 769
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 770 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 804
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 463 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 522
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 523 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 582
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 583 GMEYSYDINRVPEEQM 598
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 188 bits (478), Expect = 2e-47
Identities = 100/233 (42%), Positives = 141/233 (60%), Gaps = 26/233 (11%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 717
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEF 977
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L +EE+
Sbjct: 718 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL-------TLTTNEEY 770
Query: 978 LRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP 1030
L L PL+ S Y + + D + PDP P
Sbjct: 771 L------------------DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 805
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 464 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 523
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 524 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 583
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 584 GMEYSYDINRVPEEQM 599
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 187 bits (475), Expect = 5e-47
Identities = 87/165 (52%), Positives = 122/165 (73%), Gaps = 1/165 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 510 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 569
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 570 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 628
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L
Sbjct: 629 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 375 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 434
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 435 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 494
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 495 GMEYSYDINRVPEEQM 510
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 187 bits (475), Expect = 5e-47
Identities = 87/165 (52%), Positives = 122/165 (73%), Gaps = 1/165 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 717
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L
Sbjct: 718 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 464 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 523
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 524 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 583
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 584 GMEYSYDINRVPEEQM 599
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 187 bits (475), Expect = 5e-47
Identities = 87/165 (52%), Positives = 122/165 (73%), Gaps = 1/165 (0%)
Query: 798 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
+++ DLV +YQ+A GME+LAS+ C+HRDLAARNVL+ E ++KI DFGLARDI Y
Sbjct: 509 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 568
Query: 858 ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917
+ LP+KWMAPE++F+ +YT SDVWSFG+L+WEIFTLGG+PYP +P+ E+ + +
Sbjct: 569 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV-EELFKLL 627
Query: 918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
K G+RM +PA+ ++E+Y +M+ CW RP F QLV L+R+L
Sbjct: 628 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
Score = 117 bits (292), Expect = 8e-26
Identities = 58/136 (42%), Positives = 83/136 (61%), Gaps = 2/136 (1%)
Query: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKST 639
V +LP D WE PRD+L LG+ LG G FGQVV A A G+ + + VAVKMLK
Sbjct: 374 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 433
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT 699
A + L+SE+++M +G H N++NLLGACT+ GP+Y+I EY G+L +YL +
Sbjct: 434 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPP 493
Query: 700 FLQHHSDKRRPPSAEL 715
+++ D R P ++
Sbjct: 494 GMEYSYDINRVPEEQM 509
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 184 bits (466), Expect = 5e-46
Identities = 89/183 (48%), Positives = 125/183 (68%), Gaps = 2/183 (1%)
Query: 780 PSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKL 839
P P+ + +E P LS+ LV +YQVA GM++L S+ C+HRDLAARNVL+ E +
Sbjct: 527 PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV 585
Query: 840 VKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL 899
+KI DFGLAR + Y + LP+KWMAPE++F+ +YT SDVWSFGILLWEIFTL
Sbjct: 586 MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL 645
Query: 900 GGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLE 959
GG+PYP +P+ E+ ++ ++ G+RM +P H E+Y +M++CW RP F QLV L+
Sbjct: 646 GGSPYPGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 704
Query: 960 RLL 962
++L
Sbjct: 705 KVL 707
Score = 108 bits (270), Expect = 3e-23
Identities = 57/133 (42%), Positives = 78/133 (58%), Gaps = 14/133 (10%)
Query: 585 MQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMK--VAVKMLKSTARS 642
+ LP D WE PRD+LVLG+ LG G FGQVV A A G+ ++ VAVKMLK A
Sbjct: 412 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 471
Query: 643 SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQ 702
+ L+SE+++M +G H N++NLLG CT+ GP+Y+I E G+L ++L
Sbjct: 472 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLR-------- 523
Query: 703 HHSDKRRPPSAEL 715
RRPP +L
Sbjct: 524 ----ARRPPGPDL 532
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 184 bits (466), Expect = 5e-46
Identities = 89/183 (48%), Positives = 125/183 (68%), Gaps = 2/183 (1%)
Query: 780 PSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKL 839
P P+ + +E P LS+ LV +YQVA GM++L S+ C+HRDLAARNVL+ E +
Sbjct: 567 PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV 625
Query: 840 VKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL 899
+KI DFGLAR + Y + LP+KWMAPE++F+ +YT SDVWSFGILLWEIFTL
Sbjct: 626 MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL 685
Query: 900 GGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLE 959
GG+PYP +P+ E+ ++ ++ G+RM +P H E+Y +M++CW RP F QLV L+
Sbjct: 686 GGSPYPGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Query: 960 RLL 962
++L
Sbjct: 745 KVL 747
Score = 108 bits (270), Expect = 3e-23
Identities = 57/133 (42%), Positives = 78/133 (58%), Gaps = 14/133 (10%)
Query: 585 MQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMK--VAVKMLKSTARS 642
+ LP D WE PRD+LVLG+ LG G FGQVV A A G+ ++ VAVKMLK A
Sbjct: 452 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 511
Query: 643 SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQ 702
+ L+SE+++M +G H N++NLLG CT+ GP+Y+I E G+L ++L
Sbjct: 512 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLR-------- 563
Query: 703 HHSDKRRPPSAEL 715
RRPP +L
Sbjct: 564 ----ARRPPGPDL 572
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 184 bits (466), Expect = 5e-46
Identities = 89/183 (48%), Positives = 125/183 (68%), Gaps = 2/183 (1%)
Query: 780 PSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKL 839
P P+ + +E P LS+ LV +YQVA GM++L S+ C+HRDLAARNVL+ E +
Sbjct: 567 PPGPDLSPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV 625
Query: 840 VKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL 899
+KI DFGLAR + Y + LP+KWMAPE++F+ +YT SDVWSFGILLWEIFTL
Sbjct: 626 MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL 685
Query: 900 GGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLE 959
GG+PYP +P+ E+ ++ ++ G+RM +P H E+Y +M++CW RP F QLV L+
Sbjct: 686 GGSPYPGIPV-EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Query: 960 RLL 962
++L
Sbjct: 745 KVL 747
Score = 108 bits (270), Expect = 3e-23
Identities = 57/133 (42%), Positives = 78/133 (58%), Gaps = 14/133 (10%)
Query: 585 MQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMK--VAVKMLKSTARS 642
+ LP D WE PRD+LVLG+ LG G FGQVV A A G+ ++ VAVKMLK A
Sbjct: 452 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 511
Query: 643 SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQ 702
+ L+SE+++M +G H N++NLLG CT+ GP+Y+I E G+L ++L
Sbjct: 512 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLR-------- 563
Query: 703 HHSDKRRPPSAEL 715
RRPP +L
Sbjct: 564 ----ARRPPGPDL 572
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 183 bits (464), Expect = 9e-46
Identities = 82/185 (44%), Positives = 129/185 (69%), Gaps = 1/185 (0%)
Query: 778 YVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEG 837
Y+ S R + + L+ DL+ F++Q++ GM++LA VHRDLAARN+L+ EG
Sbjct: 826 YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 885
Query: 838 KLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIF 897
+ +KI DFGL+RD+ + +Y+ + +P+KWMA ES+F+ +YTT SDVWSFG+LLWEI
Sbjct: 886 RKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945
Query: 898 TLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLL 957
TLGG PYP +P E+ +N +K G+RM +P + S+E+Y +M +CW+++ + RP F+ +
Sbjct: 946 TLGGNPYPGIP-PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 1004
Query: 958 LERLL 962
LE+++
Sbjct: 1005 LEKMM 1009
Score = 100 bits (248), Expect = 1e-20
Identities = 51/118 (43%), Positives = 72/118 (61%), Gaps = 1/118 (0%)
Query: 580 IYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKST 639
+ VD ++ D WE PR LVLG+TLG G FG+VV+ATA L VAVKMLK
Sbjct: 704 VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN 763
Query: 640 ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNK 697
A SE + L+SE ++ + H +V+ L GAC++ GP+ +I EY +YG L +L ++
Sbjct: 764 ASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,194,565
Number of Sequences: 37866
Number of extensions: 2230372
Number of successful extensions: 12555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 573
Number of HSP's successfully gapped in prelim test: 472
Number of HSP's that attempted gapping in prelim test: 7914
Number of HSP's gapped (non-prelim): 3419
length of query: 1106
length of database: 18,247,518
effective HSP length: 113
effective length of query: 993
effective length of database: 13,968,660
effective search space: 13870879380
effective search space used: 13870879380
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.