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Search of human proteins with 130502162
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|130502162 RAS protein activator like 3 [Homo sapiens]
(1011 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|130502162 RAS protein activator like 3 [Homo sapiens] 2047 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 449 e-126
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 449 e-126
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 437 e-122
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 431 e-120
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 409 e-114
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 163 7e-40
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 163 7e-40
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 123 1e-27
gi|4759026 RAS protein activator like 1 [Homo sapiens] 108 2e-23
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 97 6e-20
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 88 5e-17
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 87 8e-17
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 87 8e-17
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 87 8e-17
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 87 8e-17
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 86 1e-16
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 86 1e-16
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 86 2e-16
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 48 4e-05
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 46 2e-04
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 45 5e-04
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 45 5e-04
gi|110349719 titin isoform N2-A [Homo sapiens] 43 0.001
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 42 0.003
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 42 0.003
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] 42 0.004
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] 42 0.004
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] 42 0.004
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 42 0.004
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 2047 bits (5304), Expect = 0.0
Identities = 1011/1011 (100%), Positives = 1011/1011 (100%)
Query: 1 MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQ 60
MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQ
Sbjct: 1 MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQ 60
Query: 61 PAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPP 120
PAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPP
Sbjct: 61 PAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPP 120
Query: 121 TPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRD 180
TPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRD
Sbjct: 121 TPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRD 180
Query: 181 PDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDL 240
PDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDL
Sbjct: 181 PDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDL 240
Query: 241 GAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVE 300
GAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVE
Sbjct: 241 GAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVE 300
Query: 301 REETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEAL 360
REETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEAL
Sbjct: 301 REETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEAL 360
Query: 361 PPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIR 420
PPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIR
Sbjct: 361 PPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIR 420
Query: 421 ARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALV 480
ARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALV
Sbjct: 421 ARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALV 480
Query: 481 TDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCE 540
TDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCE
Sbjct: 481 TDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCE 540
Query: 541 VDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLG 600
VDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLG
Sbjct: 541 VDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLG 600
Query: 601 PRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAY 660
PRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAY
Sbjct: 601 PRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAY 660
Query: 661 MGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQ 720
MGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQ
Sbjct: 661 MGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQ 720
Query: 721 TTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTP 780
TTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTP
Sbjct: 721 TTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTP 780
Query: 781 LISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKG 840
LISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKG
Sbjct: 781 LISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKG 840
Query: 841 SLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAA 900
SLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAA
Sbjct: 841 SLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAA 900
Query: 901 LREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHS 960
LREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHS
Sbjct: 901 LREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHS 960
Query: 961 LKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT 1011
LKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT
Sbjct: 961 LKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT 1011
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 449 bits (1156), Expect = e-126
Identities = 270/610 (44%), Positives = 360/610 (59%), Gaps = 54/610 (8%)
Query: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283
S ESL + S LDL E +V I P+H S+LG+ +CF+VT + GS+CFSCRSAAERD+
Sbjct: 9 SHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDK 68
Query: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPR 343
W+E+LRR P +DN R E L +WV EAK LP EL LD L ART +
Sbjct: 69 WMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKK----YLCELCLDDVLYARTTGK 124
Query: 344 AGPGQLFWAERFHFEALPPARRLSLRL------RGLGPGSAVLGRVALALEELDAPRAPA 397
+FW E F F LPP R +++ L + ++ LG V+L P A
Sbjct: 125 LKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSL-------PAASV 177
Query: 398 AG---LERWFPLL------GAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCG 448
AG +E+W+P++ G G +R + R + + +LP E YKE AE +T HY LC
Sbjct: 178 AGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCA 237
Query: 449 ALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKA 508
ALEP L A+ KEE+A+A+V +L++TG+ + +TDL +E+ RCG E L+FRENTLATKA
Sbjct: 238 ALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKA 297
Query: 509 IDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFET 568
I+EY+KLV Q YLQ+ LG+ ++ L S E+CEVDPSKC A++LPEHQ L+ CE F
Sbjct: 298 IEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCK 357
Query: 569 IIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPD 628
II+SY FP EL VF+SWR+ C RG + RL+ ASLFLR LCPAI++PSLF L +
Sbjct: 358 IINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQE 417
Query: 629 HPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVD 688
+P ARTLTLIAKV QNLAN A FG KE YM FMN FLE MQ FL +++ +
Sbjct: 418 YPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETL 477
Query: 689 AAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPM 748
+ +G++G DL +L+ LH+ L ++L+Q+ L PLP ILR + +S P
Sbjct: 478 SNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVH----TALSTPG 533
Query: 749 RLPLP--------PAQVHSSLSAG--------EKPGFLAPRDLPKHTPLISKSQSLRSVR 792
LP P SS+SAG + G + LP TP +++ L V
Sbjct: 534 SGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTP---ENKDLFFVT 590
Query: 793 RSESWARPRP 802
RS S +P P
Sbjct: 591 RS-SGVQPSP 599
Score = 34.3 bits (77), Expect = 0.61
Identities = 62/290 (21%), Positives = 107/290 (36%), Gaps = 53/290 (18%)
Query: 766 KPGFLAPRDLPKHT----PLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVP 821
+PG LA R + P + + S RR + P P R P ++
Sbjct: 761 RPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQ 820
Query: 822 VRRPARRR-QSAGP-WPRP------KGSLSMGPAPRARPWT-RDSASLPRKPSV-----P 867
RP+ SA P W P + S S G +P +P P P+
Sbjct: 821 YPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAA 880
Query: 868 WQRQMDQPQDRNQALGTHRP-------VNKLAELQCEVAALREEQKVLSRLVESLSTQIR 920
W M+ ++ LG P ++L++ + ++A L+++ ++ ++ +E T +
Sbjct: 881 WLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFK 940
Query: 921 A---------------LTEQQEQLRGQLQDLD-------SRLRAGSSEFDSEHNLTSNEG 958
L E +E+LR Q +D D SRL + E +H
Sbjct: 941 CQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAV 1000
Query: 959 HSLKNL----EHRLNEMERTQAQLRDAVQSL--QLSPRTRGSWSQPQPLK 1002
S + + E R+ ++ A+L A+ L + S + R S P K
Sbjct: 1001 DSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK 1050
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 449 bits (1156), Expect = e-126
Identities = 270/610 (44%), Positives = 360/610 (59%), Gaps = 54/610 (8%)
Query: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283
S ESL + S LDL E +V I P+H S+LG+ +CF+VT + GS+CFSCRSAAERD+
Sbjct: 105 SHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDK 164
Query: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPR 343
W+E+LRR P +DN R E L +WV EAK LP EL LD L ART +
Sbjct: 165 WMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKK----YLCELCLDDVLYARTTGK 220
Query: 344 AGPGQLFWAERFHFEALPPARRLSLRL------RGLGPGSAVLGRVALALEELDAPRAPA 397
+FW E F F LPP R +++ L + ++ LG V+L P A
Sbjct: 221 LKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSL-------PAASV 273
Query: 398 AG---LERWFPLL------GAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCG 448
AG +E+W+P++ G G +R + R + + +LP E YKE AE +T HY LC
Sbjct: 274 AGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCA 333
Query: 449 ALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKA 508
ALEP L A+ KEE+A+A+V +L++TG+ + +TDL +E+ RCG E L+FRENTLATKA
Sbjct: 334 ALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKA 393
Query: 509 IDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFET 568
I+EY+KLV Q YLQ+ LG+ ++ L S E+CEVDPSKC A++LPEHQ L+ CE F
Sbjct: 394 IEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCK 453
Query: 569 IIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPD 628
II+SY FP EL VF+SWR+ C RG + RL+ ASLFLR LCPAI++PSLF L +
Sbjct: 454 IINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQE 513
Query: 629 HPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVD 688
+P ARTLTLIAKV QNLAN A FG KE YM FMN FLE MQ FL +++ +
Sbjct: 514 YPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETL 573
Query: 689 AAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPM 748
+ +G++G DL +L+ LH+ L ++L+Q+ L PLP ILR + +S P
Sbjct: 574 SNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVH----TALSTPG 629
Query: 749 RLPLP--------PAQVHSSLSAG--------EKPGFLAPRDLPKHTPLISKSQSLRSVR 792
LP P SS+SAG + G + LP TP +++ L V
Sbjct: 630 SGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTP---ENKDLFFVT 686
Query: 793 RSESWARPRP 802
RS S +P P
Sbjct: 687 RS-SGVQPSP 695
Score = 33.1 bits (74), Expect = 1.4
Identities = 58/274 (21%), Positives = 102/274 (37%), Gaps = 51/274 (18%)
Query: 766 KPGFLAPRDLPKHT----PLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVP 821
+PG LA R + P + + S RR + P P R P ++
Sbjct: 857 RPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQ 916
Query: 822 VRRPARRR-QSAGP-WPRP------KGSLSMGPAPRARPWT-RDSASLPRKPSV-----P 867
RP+ SA P W P + S S G +P +P P P+
Sbjct: 917 YPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAA 976
Query: 868 WQRQMDQPQDRNQALGTHRP-------VNKLAELQCEVAALREEQKVLSRLVESLSTQIR 920
W M+ ++ LG P ++L++ + ++A L+++ ++ ++ +E T +
Sbjct: 977 WLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFK 1036
Query: 921 A---------------LTEQQEQLRGQLQDLD-------SRLRAGSSEFDSEHNLTSNEG 958
L E +E+LR Q +D D SRL + E +H
Sbjct: 1037 CQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAV 1096
Query: 959 HSLKNL----EHRLNEMERTQAQLRDAVQSLQLS 988
S + + E R+ ++ A+L A+ L+ S
Sbjct: 1097 DSKQKIIDAQEKRIASLDAANARLMSALTQLKES 1130
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 437 bits (1123), Expect = e-122
Identities = 267/658 (40%), Positives = 373/658 (56%), Gaps = 47/658 (7%)
Query: 154 EEGPRRPRV-GSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKK 212
E PRR + G+++SE + N P ++PG G + + L R +
Sbjct: 157 ERSPRRRSISGTSTSEKPNSMDTAN-TSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFR 215
Query: 213 KARLEPRD----GPPSALGSR--ESL----ATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
L D G P SR ESL +T+ LDLG V + PLH S+LG+ CF
Sbjct: 216 LPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCF 275
Query: 263 QVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAG 322
+VT+ GS+CFSC SA+ERD+W+E+LRR QP +DN R E L +W+ EAK L
Sbjct: 276 EVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDL------ 329
Query: 323 APGVR--AELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRL------RGLG 374
AP + EL LD L ART + +FW E F F +LPP +++ + +
Sbjct: 330 APKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKK 389
Query: 375 PGSAVLGRVALALEELDAPRAPAAG---LERWFPLL------GAPAGAALRARIRARRLR 425
+ +G V + P A G +E+W+P+ G G ++R + R + +
Sbjct: 390 DKNNYVGLVNI-------PTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTIT 442
Query: 426 VLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGT 485
+LP E+YKE AEF+T +Y LC LEP + + KEELA A+V +L++TGRA+ +TDL
Sbjct: 443 ILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 502
Query: 486 AELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSK 545
+E+ RCG + L+FRENT+ATK+I+EY+KLV Q YL + LG+ ++ L S E+CEVDPSK
Sbjct: 503 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 562
Query: 546 CPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVC 605
C +SEL +HQ+ L+ CE F II+SY FP EL VF+SW++ C RG + + RL+
Sbjct: 563 CSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLIS 622
Query: 606 ASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMN 665
ASLFLR LCPAI++PSLF L ++P +RTLTLIAKVIQNLAN A FG KE YM FMN
Sbjct: 623 ASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMN 682
Query: 666 SFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDT 725
FLE M+ FL +++ D + G+ G DL +L+VLH+ L + ++LD+ T
Sbjct: 683 DFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAK 742
Query: 726 LEPLPTILRAIEEG--QPVLVSVPMRL---PLPPAQVHSSLSAGEKPGFLAPRDLPKH 778
L PLP +L I + P + +R V SLS+G + F P D H
Sbjct: 743 LGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLH 800
Score = 33.5 bits (75), Expect = 1.0
Identities = 52/222 (23%), Positives = 83/222 (37%), Gaps = 24/222 (10%)
Query: 746 VPMRLPLP----PAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPR 801
+P+ LP AQ+ G AP LP L +S SV + A P
Sbjct: 996 IPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASL--RSTGSMSVVSAALVAEPV 1053
Query: 802 PDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLP 861
+ R R+ R VP R +R+Q+ P S +M P R W ++
Sbjct: 1054 QNGSRS-RQQSSSSRESPVPKVRAIQRQQTQQV-QSPVDSATMSPVERTAAWVLNNGQYE 1111
Query: 862 RKPSVPWQRQMDQPQDRNQALGTHRPVNKLAEL---------QCEVAALREEQKVLSRLV 912
++ +D+ + + + + KL E + E L +EQ++ L+
Sbjct: 1112 EDVEET-EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
Query: 913 E---SLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEH 951
E L L QQE+ Q++ + SRL A E +H
Sbjct: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDH 1209
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 431 bits (1109), Expect = e-120
Identities = 268/665 (40%), Positives = 373/665 (56%), Gaps = 54/665 (8%)
Query: 154 EEGPRRPRV-GSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKK 212
E PRR + G+++SE + N P ++PG G + + L R +
Sbjct: 9 ERSPRRRSISGTSTSEKPNSMDTAN-TSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFR 67
Query: 213 KARLEPRD----GPPSALGSR--ESL----ATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
L D G P SR ESL +T+ LDLG V + PLH S+LG+ CF
Sbjct: 68 LPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCF 127
Query: 263 QVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAG 322
+VT+ GS+CFSC SA+ERD+W+E+LRR QP +DN R E L +W+ EAK L
Sbjct: 128 EVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDL------ 181
Query: 323 APGVR--AELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRL------RGLG 374
AP + EL LD L ART + +FW E F F +LPP +++ + +
Sbjct: 182 APKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKK 241
Query: 375 PGSAVLGRVALALEELDAPRAPAAG---LERWFPLL------GAPAGAALRARIRARRLR 425
+ +G V + P A G +E+W+P+ G G ++R + R + +
Sbjct: 242 DKNNYVGLVNI-------PTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTIT 294
Query: 426 VLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGT 485
+LP E+YKE AEF+T +Y LC LEP + + KEELA A+V +L++TGRA+ +TDL
Sbjct: 295 ILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 354
Query: 486 AELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSK 545
+E+ RCG + L+FRENT+ATK+I+EY+KLV Q YL + LG+ ++ L S E+CEVDPSK
Sbjct: 355 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 414
Query: 546 CPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVC 605
C +SEL +HQ+ L+ CE F II+SY FP EL VF+SW++ C RG + + RL+
Sbjct: 415 CSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLIS 474
Query: 606 ASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMN 665
ASLFLR LCPAI++PSLF L ++P +RTLTLIAKVIQNLAN A FG KE YM FMN
Sbjct: 475 ASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMN 534
Query: 666 SFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELD------ 719
FLE M+ FL +++ D + G+ G DL +L+VLH+ L + ++LD
Sbjct: 535 DFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSF 594
Query: 720 -QTTRDTLEPLPTILRAIEEG--QPVLVSVPMRL---PLPPAQVHSSLSAGEKPGFLAPR 773
Q T L PLP +L I + P + +R V SLS+G + F P
Sbjct: 595 LQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPT 654
Query: 774 DLPKH 778
D H
Sbjct: 655 DSDLH 659
Score = 33.5 bits (75), Expect = 1.0
Identities = 52/222 (23%), Positives = 83/222 (37%), Gaps = 24/222 (10%)
Query: 746 VPMRLPLP----PAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPR 801
+P+ LP AQ+ G AP LP L +S SV + A P
Sbjct: 855 IPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASL--RSTGSMSVVSAALVAEPV 912
Query: 802 PDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLP 861
+ R R+ R VP R +R+Q+ P S +M P R W ++
Sbjct: 913 QNGSRS-RQQSSSSRESPVPKVRAIQRQQTQQV-QSPVDSATMSPVERTAAWVLNNGQYE 970
Query: 862 RKPSVPWQRQMDQPQDRNQALGTHRPVNKLAEL---------QCEVAALREEQKVLSRLV 912
++ +D+ + + + + KL E + E L +EQ++ L+
Sbjct: 971 EDVEET-EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
Query: 913 E---SLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEH 951
E L L QQE+ Q++ + SRL A E +H
Sbjct: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDH 1068
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 409 bits (1052), Expect = e-114
Identities = 266/648 (41%), Positives = 362/648 (55%), Gaps = 56/648 (8%)
Query: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283
S ESL + S L+L + D I P+H S+LG+ CF+VT + G++CF+CRSAAERD+
Sbjct: 182 SHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDK 241
Query: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVR--AELWLDGALLARTA 341
WIE+L+R +P +DN R + L +W+ EA+ LP P R EL LD L ART
Sbjct: 242 WIENLQRAVKPNKDNSRRVDNVLKLWIIEARELP------PKKRYYCELCLDDMLYARTT 295
Query: 342 --PRAGPGQ-LFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAA 398
PR+ G +FW E F F LP R L L L + + + P A A
Sbjct: 296 SKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGY-VGLVTVPVATLA 354
Query: 399 G---LERWFPL-----------LGAPAGA---------------ALRARIRARRLRVLPS 429
G E+W+P+ +G+ G A+R + R + + +LP
Sbjct: 355 GRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPM 414
Query: 430 ERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELA 489
E YKE AE++T HY LC LEPAL + KEE+A+A+V +L++TG+A+ ++D+ +E+
Sbjct: 415 ELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVD 474
Query: 490 RCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPAS 549
R RE L+FRENTLATKAI+EYM+L+ Q YL++ +G+ +R L S E+CEVDP KC AS
Sbjct: 475 RFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTAS 534
Query: 550 ELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLF 609
L EHQA LR CE +++S+ FP EL VF+SWR C ERG E + RL+ ASLF
Sbjct: 535 SLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLF 594
Query: 610 LRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLE 669
LR LCPAI++PSLFGL ++P +RTLTLIAKVIQNLAN + F KE ++GFMN FLE
Sbjct: 595 LRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLE 654
Query: 670 EHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPL 729
+MQ FL +++ +D S ++G DL +L+ LHA L + +L + L PL
Sbjct: 655 LEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPL 714
Query: 730 PTILRAIEEG--QPVLVSVPMR---LPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISK 784
P +L I P + P R P P V SA E G++ RDL L +
Sbjct: 715 PRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSA-EMQGYMM-RDLNSSIDL--Q 770
Query: 785 SQSLRSVRRSESWAR-PRPDEERPLRRPRPVQRTQSVPVRRPARRRQS 831
S R + S AR P P +E+P P P V RP R S
Sbjct: 771 SFMARGLNSSMDMARLPSPTKEKP-PPPPPGGGKDLFYVSRPPLARSS 817
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 163 bits (413), Expect = 7e-40
Identities = 134/491 (27%), Positives = 227/491 (46%), Gaps = 31/491 (6%)
Query: 248 IWPLHPSLLGEPHCFQVTWTGGSR-----CFSCRSAAERDRWIE------DLRRQFQPTQ 296
++ +H SL G P+CFQ+ S F+ + + + W++ +LR+ T
Sbjct: 527 VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTS 586
Query: 297 DNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFH 356
+ R+ + L + + EA LP P ++L+ +A+T R G + W+E F
Sbjct: 587 NKRLRQVSSLVLHIEEAHKLPVKHFTNP--YCNIYLNSVQVAKTHAREGQNPV-WSEEFV 643
Query: 357 FEALPP-ARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWF------PLLGA 409
F+ LPP R + L S + + + + A + WF PL G
Sbjct: 644 FDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHAT--DEWFLLSSHIPLKGI 701
Query: 410 PAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRV 469
G+ LR R R +++P E Y E E + + AL Q + LA+ ++R+
Sbjct: 702 EPGS-LRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVC-GQDRTLLASILLRI 759
Query: 470 LRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVV 529
L+ L E++ LFR TLA+ +++YMK A ++ L +
Sbjct: 760 FLHEKLESLLLCTLNDREISM-EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSI 818
Query: 530 RRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWR 588
++ S + CE+ PSK +E + + L N E+ E I + + P L ++ +
Sbjct: 819 LKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQ 878
Query: 589 EACKERG--SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQ 646
++ + + + + R+V +FLRL+CPAIL P +F + D P+P ARTL L+AK +Q
Sbjct: 879 KSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQ 938
Query: 647 NLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAV 706
NLAN FG KE YM +N F++ + M FLD++ V + + DL+ LA
Sbjct: 939 NLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVP-ELPDTTEHSRTDLSRDLAA 997
Query: 707 LHAQLCTIFAE 717
LH ++C ++
Sbjct: 998 LH-EICVAHSD 1007
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 163 bits (413), Expect = 7e-40
Identities = 134/491 (27%), Positives = 227/491 (46%), Gaps = 31/491 (6%)
Query: 248 IWPLHPSLLGEPHCFQVTWTGGSR-----CFSCRSAAERDRWIE------DLRRQFQPTQ 296
++ +H SL G P+CFQ+ S F+ + + + W++ +LR+ T
Sbjct: 350 VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTS 409
Query: 297 DNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFH 356
+ R+ + L + + EA LP P ++L+ +A+T R G + W+E F
Sbjct: 410 NKRLRQVSSLVLHIEEAHKLPVKHFTNP--YCNIYLNSVQVAKTHAREGQNPV-WSEEFV 466
Query: 357 FEALPP-ARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWF------PLLGA 409
F+ LPP R + L S + + + + A + WF PL G
Sbjct: 467 FDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHAT--DEWFLLSSHIPLKGI 524
Query: 410 PAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRV 469
G+ LR R R +++P E Y E E + + AL Q + LA+ ++R+
Sbjct: 525 EPGS-LRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVC-GQDRTLLASILLRI 582
Query: 470 LRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVV 529
L+ L E++ LFR TLA+ +++YMK A ++ L +
Sbjct: 583 FLHEKLESLLLCTLNDREISM-EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSI 641
Query: 530 RRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWR 588
++ S + CE+ PSK +E + + L N E+ E I + + P L ++ +
Sbjct: 642 LKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQ 701
Query: 589 EACKERG--SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQ 646
++ + + + + R+V +FLRL+CPAIL P +F + D P+P ARTL L+AK +Q
Sbjct: 702 KSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQ 761
Query: 647 NLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAV 706
NLAN FG KE YM +N F++ + M FLD++ V + + DL+ LA
Sbjct: 762 NLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVP-ELPDTTEHSRTDLSRDLAA 820
Query: 707 LHAQLCTIFAE 717
LH ++C ++
Sbjct: 821 LH-EICVAHSD 830
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 123 bits (308), Expect = 1e-27
Identities = 83/233 (35%), Positives = 118/233 (50%), Gaps = 9/233 (3%)
Query: 459 KEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQ 518
K+E A +VR+ GR ++ + +AE+ R + FR N+LA+K IDE MKL
Sbjct: 331 KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTI-FRGNSLASKCIDETMKLAGM 389
Query: 519 DYLQETLGQVVRRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFP 577
YL TL + +C S + CE+DP K E L + LR + VF I S P
Sbjct: 390 HYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCP 449
Query: 578 AELGIVFSSWREACKERGSEVLGPRLVCAS--LFLRLLCPAILAPSLFGLAPDHPAPGPA 635
+ +F S REA +R + R S +FLR PAIL+P+LF L P H P +
Sbjct: 450 TVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTS 509
Query: 636 RTLTLIAKVIQNLANRAPFGE---KEAYMGFMNSFLEE--HGPAMQCFLDQVA 683
RTLTLI+K +Q L + + KE+YM F E + A++ FLD ++
Sbjct: 510 RTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLIS 562
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 108 bits (271), Expect = 2e-23
Identities = 96/325 (29%), Positives = 143/325 (44%), Gaps = 38/325 (11%)
Query: 403 WFPLLGAPAG--------AALRARIRARRLRVLPSERYKELAEFLTFHY--------ARL 446
WF LL P ALR ++R RVLPS+ Y+ L E L A
Sbjct: 230 WFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASP 289
Query: 447 CGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLAT 506
LE +++LA +V++ G A + L E+AR L FR N+LA+
Sbjct: 290 LALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLAS 348
Query: 507 KAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASE---------LPEHQAR 557
K+++++MKLV YL E L V+ R+ + E+DP K L E Q R
Sbjct: 349 KSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMR 408
Query: 558 ------LRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEV----LGPRLVCAS 607
L + + I+ S P + + F +ER + + +
Sbjct: 409 ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGF 468
Query: 608 LFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRA-PFGE-KEAYMGFMN 665
LFLR PAIL P LF L H P +R+L L+AK +Q++ N G+ KE +M ++
Sbjct: 469 LFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLH 528
Query: 666 SFLEEHGPAMQCFLDQVAMVDVDAA 690
FL + ++ FLD++ VD D A
Sbjct: 529 PFLLQCVSRVRDFLDRLVDVDGDEA 553
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 97.4 bits (241), Expect = 6e-20
Identities = 65/199 (32%), Positives = 107/199 (53%), Gaps = 10/199 (5%)
Query: 498 LFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASE-LPEHQA 556
+FR N+LAT+ +DE MK+V YL+ TL ++ +C S++ CE+DP K + + ++
Sbjct: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKE 454
Query: 557 RLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLFLRLLC 614
LR +++F TI+ S P + +F S R+ +R + V + +FLR
Sbjct: 455 NLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFA 514
Query: 615 PAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLA-----NRAPFGEKEAYM-GFMNSFL 668
A+++P F L P HP RTLTLI+K IQ L +++ KE +M F F
Sbjct: 515 VAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQ 574
Query: 669 EE-HGPAMQCFLDQVAMVD 686
EE + A++ FLD+++ +
Sbjct: 575 EEGYIIAVKKFLDEISSTE 593
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 87.8 bits (216), Expect = 5e-17
Identities = 74/265 (27%), Positives = 131/265 (49%), Gaps = 14/265 (5%)
Query: 429 SERYKELAEFLTFHYAR----LCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLG 484
++R++ L E +T + + AL +P +ELA +V + + L+ ++
Sbjct: 1202 ADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMF 1261
Query: 485 TAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTE----DCE 540
+ E+ + L FR N+LA+K + K+ YLQ+ L ++R + S++ E
Sbjct: 1262 SKEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
Query: 541 VDPSKC-PASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSE-V 598
VDP++ P+ L E+Q L E+ F II S FP +L V + +R +
Sbjct: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS 1380
Query: 599 LGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKE 658
+G V +++FLR + PAI++P G+ P P R L L++K++Q++AN F KE
Sbjct: 1381 IGA--VGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKE 1437
Query: 659 AYMGFMNSFLEEHGPAMQCFLDQVA 683
+M N F++ + A + F +A
Sbjct: 1438 EHMRPFNDFVKSNFDAARRFFLDIA 1462
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 87.0 bits (214), Expect = 8e-17
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 179 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 238
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 239 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 297
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 298 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 357
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 358 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 417
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 418 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 475
Query: 686 DVD 688
D++
Sbjct: 476 DIE 478
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 87.0 bits (214), Expect = 8e-17
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 369
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 547
Query: 686 DVD 688
D++
Sbjct: 548 DIE 550
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 87.0 bits (214), Expect = 8e-17
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 179 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 238
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 239 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 297
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 298 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 357
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 358 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 417
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 418 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 475
Query: 686 DVD 688
D++
Sbjct: 476 DIE 478
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 87.0 bits (214), Expect = 8e-17
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 369
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 547
Query: 686 DVD 688
D++
Sbjct: 548 DIE 550
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHGVLG 369
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITK--LV 547
Query: 686 DVD 688
D++
Sbjct: 548 DIE 550
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
Query: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHGVLG 369
Query: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
Query: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
Query: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITK--LV 547
Query: 686 DVD 688
D++
Sbjct: 548 DIE 550
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 85.9 bits (211), Expect = 2e-16
Identities = 76/284 (26%), Positives = 133/284 (46%), Gaps = 31/284 (10%)
Query: 429 SERYKELAEFLTFHYAR----LCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLG 484
++R++ L E +T + + AL +P +ELA +V + + L+ ++
Sbjct: 1202 ADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMF 1261
Query: 485 TAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTE----DCE 540
+ E+ + L FR N+LA+K + K+ YLQ+ L ++R + S++ E
Sbjct: 1262 SKEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
Query: 541 VDPSKC-PASELPEHQARLRNSCEEVFETIIHSYDWFPAEL-GIVFSSWREAC------- 591
VDP++ P+ L E+Q L E+ F II S FP +L + ++ C
Sbjct: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKA 1380
Query: 592 -----KERGSEVLGPRL-------VCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLT 639
KE V+ R V +++FLR + PAI++P G+ P P R L
Sbjct: 1381 TVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLK 1440
Query: 640 LIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVA 683
L++K++Q++AN F KE +M N F++ + A + F +A
Sbjct: 1441 LMSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRFFLDIA 1483
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.1 bits (113), Expect = 4e-05
Identities = 61/265 (23%), Positives = 91/265 (34%), Gaps = 34/265 (12%)
Query: 753 PPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPR 812
P +V A E P P D KSQS R + A P P P
Sbjct: 504 PKGRVRRKEEAKESPSAAGPED---------KSQSKRRASNEKESAAPASPAPSPAPSPT 554
Query: 813 PVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWT----------RDSASLPR 862
P P ++ Q P L+ PAP A P T R+ A+
Sbjct: 555 PA----------PPQKEQPPAETPTDAAVLTSPPAP-APPVTPSKPMAGTTDREEATRLL 603
Query: 863 KPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRAL 922
R+ + +++ + L R E A R E++ +R E + +A
Sbjct: 604 AEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQ 663
Query: 923 TEQQEQLRGQLQ----DLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQL 978
EQ+EQ R Q Q + SR A + E + E + + M+RT+
Sbjct: 664 AEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
Query: 979 RDAVQSLQLSPRTRGSWSQPQPLKA 1003
+ Q S + S P+P+KA
Sbjct: 724 VSETKQKQDSKEANANGSSPEPVKA 748
Score = 31.2 bits (69), Expect = 5.2
Identities = 39/148 (26%), Positives = 58/148 (39%), Gaps = 22/148 (14%)
Query: 97 PPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGE--- 153
PPEP P PE + P P P + +P+ P P K + L E
Sbjct: 22 PPEPRPSPEGD-----PSPPPPPMSALVPDTPPDTPPAMK----NATSSKQLPLEPESPS 72
Query: 154 -EEGPR--RPRVGSASSE----GSIHVAMGNFRD--PDRMPGKTEPETAGPNQVHNVRGL 204
+ GPR P+ S SSE G AMG RD P R + P + +
Sbjct: 73 GQVGPRPAPPQEESPSSEAKSRGPTPPAMGP-RDARPPRRSSQPSPTAVPASDSPPTKQE 131
Query: 205 LKRLKEKKKARLEPRDGPPSALGSRESL 232
+K+ E+ K E R+ L +++++
Sbjct: 132 VKKAGERHKLAKERREERAKYLAAKKAV 159
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 46.2 bits (108), Expect = 2e-04
Identities = 50/176 (28%), Positives = 64/176 (36%), Gaps = 19/176 (10%)
Query: 3 PPSPSRTSQTQPTA-----TSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMV 57
PP+P S TA +P TS G AGG G G L +P+
Sbjct: 1380 PPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGP--GTPQGLTSELETSQPLA 1437
Query: 58 STQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPEL 117
T AP ++ V+ P A R PPP P+P P P+ P L
Sbjct: 1438 ETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQ----PAL 1493
Query: 118 EPPTPQIPEA------PTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASS 167
P P +P A T +P +G T+ L + EGP PRVG S
Sbjct: 1494 GQPAPLLPAAVGAVSLATSQLPSPPLGP-TVPPQPPSALESDGEGP-PPRVGFVDS 1547
Score = 30.4 bits (67), Expect = 8.8
Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 5/39 (12%)
Query: 97 PPEPDPEPEQEAPELEPEPELEPPTPQIPEAPT-PNVPV 134
PP+P P+ P L P+P L PP P +P PT P PV
Sbjct: 945 PPQPTLPPQ---PVLPPQPTL-PPQPVLPPQPTRPPQPV 979
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 53/205 (25%)
Query: 782 ISKSQSLRSVRRSESWARPRPDE-ERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKG 840
+ +++ R R + R R E E+ L + R ++R + R+ RR++A
Sbjct: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAA-------- 437
Query: 841 SLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAA 900
K + QRQ++ ++R Q L +N+ + Q ++
Sbjct: 438 ----------------------KRELERQRQLEWERNRRQEL-----LNQRNKEQEDIVV 470
Query: 901 LREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHS 960
L+ ++K +L ++ AL +++ QL G+LQD+ RL E +S +
Sbjct: 471 LKAKKK-------TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTN--------- 514
Query: 961 LKNLEHRLNEMERTQAQLRDAVQSL 985
K+ E R+ E+ Q QL+++ Q L
Sbjct: 515 -KSRELRIAEITHLQQQLQESQQML 538
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 53/205 (25%)
Query: 782 ISKSQSLRSVRRSESWARPRPDE-ERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKG 840
+ +++ R R + R R E E+ L + R ++R + R+ RR++A
Sbjct: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAA-------- 437
Query: 841 SLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAA 900
K + QRQ++ ++R Q L +N+ + Q ++
Sbjct: 438 ----------------------KRELERQRQLEWERNRRQEL-----LNQRNKEQEDIVV 470
Query: 901 LREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHS 960
L+ ++K +L ++ AL +++ QL G+LQD+ RL E +S +
Sbjct: 471 LKAKKK-------TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTN--------- 514
Query: 961 LKNLEHRLNEMERTQAQLRDAVQSL 985
K+ E R+ E+ Q QL+++ Q L
Sbjct: 515 -KSRELRIAEITHLQQQLQESQQML 538
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/46 (50%), Positives = 27/46 (58%), Gaps = 4/46 (8%)
Query: 92 RHKNPPPEPDPEPEQEAPELEPEPELEPPTP----QIPEAPTPNVP 133
R ++PPPE EPE+ APE E PE E P P + PE P P VP
Sbjct: 10795 RAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVP 10840
Score = 38.1 bits (87), Expect = 0.042
Identities = 19/42 (45%), Positives = 26/42 (61%), Gaps = 4/42 (9%)
Query: 96 PPPEPDPEPEQEAPE-LEPEP---ELEPPTPQIPEAPTPNVP 133
PPP+ PE+ APE + P P ++EPP P++PE P VP
Sbjct: 9284 PPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVP 9325
Score = 37.4 bits (85), Expect = 0.072
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 27/163 (16%)
Query: 66 IFRRVLSAPPK--ESRTSRLRLSKALWGRHKNPPPEPDPE------PEQEAPELEPEPEL 117
I +RV + P + E + ++ L + + + PPP PE PE++ P P+ E
Sbjct: 9543 ISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEK 9602
Query: 118 EPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRR--PRVGSASSEGSIHVAM 175
PP P++PE P VP + K++ + EE P + R + E + VA+
Sbjct: 9603 VPP-PKVPEEPKKPVPEKKV------PPKVIKM--EEPLPAKVTERHMQITQEEKVLVAV 9653
Query: 176 GNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEP 218
P + EP+ A P + K LK K K EP
Sbjct: 9654 TKKEAPPKARVPEEPKRAVPEE--------KVLKLKPKREEEP 9688
Score = 37.4 bits (85), Expect = 0.072
Identities = 28/124 (22%), Positives = 56/124 (45%), Gaps = 18/124 (14%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEE 155
PP EP+PE E P+L+P P PP P P ++ + +++
Sbjct: 10862 PPKEPEPEKVIEKPKLKPRP---PPPPPAPPKEDVKEKIFQLKAIP-----------KKK 10907
Query: 156 GPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKAR 215
P +P+V + V G + +P + +PE P + ++ +L++ E+++ +
Sbjct: 10908 VPEKPQVPEKVELTPLKVPGGEKKVRKLLP-ERKPE---PKEEVVLKSVLRKRPEEEEPK 10963
Query: 216 LEPR 219
+EP+
Sbjct: 10964 VEPK 10967
Score = 36.2 bits (82), Expect = 0.16
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 9/86 (10%)
Query: 48 RALSHQEPMVSTQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQE 107
+ + +EP P+ I P+E R ++ + L PP E PE +
Sbjct: 10458 KVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVL------PPKEVVPEKKVP 10511
Query: 108 APELEPEPELEPPTPQIPEAPTPNVP 133
P P + E P P++PEAP VP
Sbjct: 10512 VP---PAKKPEAPPPKVPEAPKEVVP 10534
Score = 34.3 bits (77), Expect = 0.61
Identities = 20/51 (39%), Positives = 27/51 (52%), Gaps = 8/51 (15%)
Query: 92 RHKNPPPEPDPE----PEQEAPELEPEPELEPP--TPQIPEAPTP--NVPV 134
+ K PP PE PE++ P L P+ E PP P++P+ P P VPV
Sbjct: 9969 KKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPV 10019
Score = 34.3 bits (77), Expect = 0.61
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 7/43 (16%)
Query: 97 PPEPDPE------PEQEAPELEPEPELEPPTPQIPEAPTPNVP 133
PP PE PE++ PE P P+ E P P++PEAP VP
Sbjct: 10549 PPTKVPEVPKAAVPEKKVPEAIP-PKPESPPPEVPEAPKEVVP 10590
Score = 33.9 bits (76), Expect = 0.79
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Query: 57 VSTQPAPRSIF--RRVLSAPPKESRTSRLRLSKA--LWGRHKNPPPEPDPEPEQEAPELE 112
V AP+ + ++V PPK+ ++ + + K P P+PE PE+
Sbjct: 10607 VKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVF 10666
Query: 113 PEPE---LEPPTPQIPEAPTPNVP 133
EPE LE P ++ E P P P
Sbjct: 10667 EEPEEVALEEPPAEVVEEPEPAAP 10690
Score = 33.5 bits (75), Expect = 1.0
Identities = 15/37 (40%), Positives = 18/37 (48%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNV 132
P PEP P+PE E ++P P PTP P V
Sbjct: 11017 PAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVV 11053
Score = 33.1 bits (74), Expect = 1.4
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 97 PPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTP--NVPV 134
P +P PE ++ P + EP P P++P+ P P +PV
Sbjct: 9320 PKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPV 9359
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 84 RLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPT--PNVPV 134
++ +A+ + ++PPPE EPE+ A E P +E P P P T P PV
Sbjct: 10649 KVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPV 10701
Score = 32.7 bits (73), Expect = 1.8
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 92 RHKNPPPEPDPEPEQEAPE-LEPEPELE---PPTPQIPEAPTPNVP 133
R ++PPP P+++ PE +P P E PP P++P P VP
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVP 9436
Score = 32.3 bits (72), Expect = 2.3
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 53 QEPMVSTQPAPRSIF--RRVLSAPPKESRTSRLRLSKALWG--RHKNPPPEPDPEPEQEA 108
+ P AP+ + ++V +APPK+ + +++ +A K P P +PE
Sbjct: 10575 ESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPP 10634
Query: 109 PELEPEPELEPPTPQIPEA--PTPNVP 133
++ P++ P ++PEA P P P
Sbjct: 10635 TKVPEVPKVAVPEKKVPEAIPPKPESP 10661
Score = 32.0 bits (71), Expect = 3.0
Identities = 35/146 (23%), Positives = 61/146 (41%), Gaps = 23/146 (15%)
Query: 733 LRAIEEGQ-PVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSV 791
L+AI + + P VP ++ L P +V GEK + LP+ P + L+SV
Sbjct: 10900 LKAIPKKKVPEKPQVPEKVELTPLKV----PGGEKK---VRKLLPERKPEPKEEVVLKSV 10952
Query: 792 RRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRAR 851
R RP+EE P P+ +++ + V P P P+P + + +
Sbjct: 10953 LRK------RPEEEEPKVEPKKLEKVKKPAVPEP--------PPPKPVEEVEVPTVTKRE 10998
Query: 852 PWTRDSASLPR-KPSVPWQRQMDQPQ 876
+ +P KP++P +P+
Sbjct: 10999 RKIPEPTKVPEIKPAIPLPAPEPKPK 11024
Score = 31.2 bits (69), Expect = 5.2
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 96 PPPEPDPEPEQEAPELE----PEPELEPPTPQIPEAPTPNVP 133
PPP+ P + PE+ PE ++ P PE+P P VP
Sbjct: 10541 PPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVP 10582
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/71 (36%), Positives = 32/71 (45%), Gaps = 17/71 (23%)
Query: 74 PPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELE--------------PEPELEP 119
PP + L+ + G + PPEP+PEPE PELE PEP EP
Sbjct: 4460 PPTPEGSPILKRKLGVDGVEEELPPEPEPEPE---PELEPEKADAENGEKEEVPEPTPEP 4516
Query: 120 PTPQIPEAPTP 130
P Q P +P P
Sbjct: 4517 PKKQAPPSPPP 4527
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/71 (36%), Positives = 32/71 (45%), Gaps = 17/71 (23%)
Query: 74 PPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELE--------------PEPELEP 119
PP + L+ + G + PPEP+PEPE PELE PEP EP
Sbjct: 4465 PPTPEGSPILKRKLGVDGVEEELPPEPEPEPE---PELEPEKADAENGEKEEVPEPTPEP 4521
Query: 120 PTPQIPEAPTP 130
P Q P +P P
Sbjct: 4522 PKKQAPPSPPP 4532
>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
Length = 629
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/206 (26%), Positives = 83/206 (40%), Gaps = 44/206 (21%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPT---PQIPEAPT-PNVPVWDIGGFTLLDGKLVLLG 151
P PEP P A L P PE PP+ Q PE P P V W++G T +
Sbjct: 34 PAPEPSRAP---ASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITY---DTLSAQ 87
Query: 152 GEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQ--------VHNVRG 203
+++GP PR +G+ P ++ G+ P P Q ++
Sbjct: 88 AQQDGPCTPR-----------RCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYS 136
Query: 204 LLKRL-KEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
+KR + + RL+ + +A G+ + SEL GA+ + W P +G
Sbjct: 137 SIKRSGSQAHEQRLQEVEAEVAATGTYQ--LRESELVFGAK---QAWRNAPRCVG----- 186
Query: 263 QVTWTGGSRCF---SCRSAAERDRWI 285
++ W G + F CRSA E +I
Sbjct: 187 RIQW-GKLQVFDARDCRSAQEMFTYI 211
>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
Length = 614
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/206 (26%), Positives = 83/206 (40%), Gaps = 44/206 (21%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPT---PQIPEAPT-PNVPVWDIGGFTLLDGKLVLLG 151
P PEP P A L P PE PP+ Q PE P P V W++G T +
Sbjct: 34 PAPEPSRAP---ASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITY---DTLSAQ 87
Query: 152 GEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQ--------VHNVRG 203
+++GP PR +G+ P ++ G+ P P Q ++
Sbjct: 88 AQQDGPCTPR-----------RCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYS 136
Query: 204 LLKRL-KEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
+KR + + RL+ + +A G+ + SEL GA+ + W P +G
Sbjct: 137 SIKRSGSQAHEQRLQEVEAEVAATGTYQ--LRESELVFGAK---QAWRNAPRCVG----- 186
Query: 263 QVTWTGGSRCF---SCRSAAERDRWI 285
++ W G + F CRSA E +I
Sbjct: 187 RIQW-GKLQVFDARDCRSAQEMFTYI 211
>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
Length = 596
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/206 (26%), Positives = 83/206 (40%), Gaps = 44/206 (21%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPT---PQIPEAPT-PNVPVWDIGGFTLLDGKLVLLG 151
P PEP P A L P PE PP+ Q PE P P V W++G T +
Sbjct: 34 PAPEPSRAP---ASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITY---DTLSAQ 87
Query: 152 GEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQ--------VHNVRG 203
+++GP PR +G+ P ++ G+ P P Q ++
Sbjct: 88 AQQDGPCTPR-----------RCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYS 136
Query: 204 LLKRL-KEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
+KR + + RL+ + +A G+ + SEL GA+ + W P +G
Sbjct: 137 SIKRSGSQAHEQRLQEVEAEVAATGTYQ--LRESELVFGAK---QAWRNAPRCVG----- 186
Query: 263 QVTWTGGSRCF---SCRSAAERDRWI 285
++ W G + F CRSA E +I
Sbjct: 187 RIQW-GKLQVFDARDCRSAQEMFTYI 211
>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
Length = 1203
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/206 (26%), Positives = 83/206 (40%), Gaps = 44/206 (21%)
Query: 96 PPPEPDPEPEQEAPELEPEPELEPPT---PQIPEAPT-PNVPVWDIGGFTLLDGKLVLLG 151
P PEP P A L P PE PP+ Q PE P P V W++G T +
Sbjct: 34 PAPEPSRAP---ASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITY---DTLSAQ 87
Query: 152 GEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQ--------VHNVRG 203
+++GP PR +G+ P ++ G+ P P Q ++
Sbjct: 88 AQQDGPCTPR-----------RCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYS 136
Query: 204 LLKRL-KEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
+KR + + RL+ + +A G+ + SEL GA+ + W P +G
Sbjct: 137 SIKRSGSQAHEQRLQEVEAEVAATGTYQ--LRESELVFGAK---QAWRNAPRCVG----- 186
Query: 263 QVTWTGGSRCF---SCRSAAERDRWI 285
++ W G + F CRSA E +I
Sbjct: 187 RIQW-GKLQVFDARDCRSAQEMFTYI 211
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,839,243
Number of Sequences: 37866
Number of extensions: 2712330
Number of successful extensions: 22203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 597
Number of HSP's that attempted gapping in prelim test: 16969
Number of HSP's gapped (non-prelim): 4944
length of query: 1011
length of database: 18,247,518
effective HSP length: 112
effective length of query: 899
effective length of database: 14,006,526
effective search space: 12591866874
effective search space used: 12591866874
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.