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Search of human proteins with 4502907
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
(247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens] 512 e-145
gi|4503149 cathepsin G preproprotein [Homo sapiens] 248 3e-66
gi|221625528 granzyme B precursor [Homo sapiens] 243 1e-64
gi|15529990 granzyme H [Homo sapiens] 226 1e-59
gi|71361688 myeloblastin [Homo sapiens] 162 3e-40
gi|42544239 complement factor D preproprotein [Homo sapiens] 160 1e-39
gi|5453676 granzyme A precursor [Homo sapiens] 159 3e-39
gi|21327705 stratum corneum chymotryptic enzyme preproprotein [H... 155 4e-38
gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Ho... 155 4e-38
gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens] 149 2e-36
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens] 144 7e-35
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens] 144 7e-35
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens] 141 5e-34
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 141 5e-34
gi|4502173 prostate specific antigen isoform 1 preproprotein [Ho... 141 6e-34
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 139 3e-33
gi|91823048 kallikrein 14 preproprotein [Homo sapiens] 138 5e-33
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s... 136 1e-32
gi|47551347 protease, serine-like 1 [Homo sapiens] 135 3e-32
gi|4504235 granzyme K precursor [Homo sapiens] 135 3e-32
gi|11496281 kallikrein 13 precursor [Homo sapiens] 135 4e-32
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot... 133 2e-31
gi|4504875 kallikrein 1 preproprotein [Homo sapiens] 131 5e-31
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 128 4e-30
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 126 2e-29
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 126 2e-29
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 125 3e-29
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens] 125 3e-29
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 125 3e-29
gi|22208987 kallikrein 12 isoform 2 [Homo sapiens] 123 2e-28
>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
Length = 247
Score = 512 bits (1319), Expect = e-145
Identities = 247/247 (100%), Positives = 247/247 (100%)
Query: 1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF 60
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
Sbjct: 1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF 60
Query: 61 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA 120
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
Sbjct: 61 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA 120
Query: 121 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD 180
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
Sbjct: 121 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD 180
Query: 181 FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI 240
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
Sbjct: 181 FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI 240
Query: 241 NQILQAN 247
NQILQAN
Sbjct: 241 NQILQAN 247
>gi|4503149 cathepsin G preproprotein [Homo sapiens]
Length = 255
Score = 248 bits (633), Expect = 3e-66
Identities = 128/242 (52%), Positives = 164/242 (67%), Gaps = 3/242 (1%)
Query: 6 LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65
L LL FLL + AEAGEIIGG E +PHSRPYMAYL+I + G S+ CGGFL+R +FVLTAA
Sbjct: 5 LLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSR-CGGFLVREDFVLTAA 63
Query: 66 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125
HC G +I VTLGAHNI E+T Q + + RHP+YN T+ +DIMLL+L +
Sbjct: 64 HCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRN 123
Query: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLM-DPQACSHFRDFDHN 184
V + P + PG +C VAGWGR ++ G+DTL+EV+LR+ D Q F +D
Sbjct: 124 VNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIFGSYDPR 182
Query: 185 LQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQIL 244
Q+CVG+ R+ K+AFKGDSGGPLLC VA GIVSYG+S PP VFTR+S + PWI +
Sbjct: 183 RQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTM 242
Query: 245 QA 246
++
Sbjct: 243 RS 244
>gi|221625528 granzyme B precursor [Homo sapiens]
Length = 247
Score = 243 bits (620), Expect = 1e-64
Identities = 130/244 (53%), Positives = 162/244 (66%), Gaps = 7/244 (2%)
Query: 6 LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65
L LL FLL RA+AGEIIGG E KPHSRPYMAYL ++ K CGGFLIR +FVLTAA
Sbjct: 5 LLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYL-MIWDQKSLKRCGGFLIRDDFVLTAA 63
Query: 66 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125
HC G SI VTLGAHNI E+E T Q + V + HP YN +DIMLL+L+ KA T A
Sbjct: 64 HCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRA 123
Query: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACS----HFRDF 181
V L PS V PG+ C VAGWG+T L S TLQEVK+ + + + C H+ +
Sbjct: 124 VQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY--Y 181
Query: 182 DHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWIN 241
D ++LCVG+P K++FKGDSGGPL+C VAQGIVSYGR++ PP T++S + WI
Sbjct: 182 DSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIK 241
Query: 242 QILQ 245
+ ++
Sbjct: 242 KTMK 245
>gi|15529990 granzyme H [Homo sapiens]
Length = 246
Score = 226 bits (577), Expect = 1e-59
Identities = 118/242 (48%), Positives = 153/242 (63%), Gaps = 4/242 (1%)
Query: 6 LPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65
L LL FLL A EIIGG E KPHSRPYMA+++ + K CGG L+R++FVLTAA
Sbjct: 5 LLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKS-RKRCGGILVRKDFVLTAA 63
Query: 66 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125
HC G SI VTLGAHNI E+E T Q + V + HP YN +DIMLL+L+ KA T A
Sbjct: 64 HCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTA 123
Query: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF--RDFDH 183
V L PS V PG++C VAGWG + + TLQEV L + C ++
Sbjct: 124 VRPLRLPSSKAQVKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDCQCERLFHGNYSR 182
Query: 184 NLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQI 243
++CVG+P+KT++ FKGDSGGPL+C VAQGI+SYG PP V+ ++SH+ PWI +
Sbjct: 183 ATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRT 242
Query: 244 LQ 245
++
Sbjct: 243 MK 244
>gi|71361688 myeloblastin [Homo sapiens]
Length = 256
Score = 162 bits (410), Expect = 3e-40
Identities = 99/245 (40%), Positives = 133/245 (54%), Gaps = 17/245 (6%)
Query: 8 LLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHC 67
LL LL A A EI+GG E +PHSRPYMA L++ N S FCGG LI +FVLTAAHC
Sbjct: 14 LLALLLSGAARAAEIVGGHEAQPHSRPYMASLQM-RGNPGSHFCGGTLIHPSFVLTAAHC 72
Query: 68 AG----RSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLT 123
R + V LGAHN+ +E T Q V + F + Y+ +D++L++L A+L+
Sbjct: 73 LRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDVLLIQLSSPANLS 131
Query: 124 LAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDH 183
+V T+ P Q VP G C GWGR G P + LQE+ + ++ F H
Sbjct: 132 ASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVT------FFCRPH 185
Query: 184 NLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGI---VSYGRSDAKPPAVFTRISHYRPWI 240
N +C PR+ GDSGGPL+C G+ QGI V +G + P FTR++ Y WI
Sbjct: 186 N--ICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWI 243
Query: 241 NQILQ 245
L+
Sbjct: 244 RSTLR 248
>gi|42544239 complement factor D preproprotein [Homo sapiens]
Length = 253
Score = 160 bits (404), Expect = 1e-39
Identities = 93/252 (36%), Positives = 141/252 (55%), Gaps = 16/252 (6%)
Query: 3 LLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVL 62
L L LL C+ G I+GG E + H+RPYMA +++ NG + CGG L+ +VL
Sbjct: 7 LAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQL---NG-AHLCGGVLVAEQWVL 62
Query: 63 TAAHC----AGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKE 118
+AAHC A + V LGAH++++ E + + +V++ HP T+ HD++LL+L E
Sbjct: 63 SAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSE 122
Query: 119 KASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF 178
KA+L AV LP+ V PG +C VAGWG D+LQ V L ++D C+
Sbjct: 123 KATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRR 182
Query: 179 RDFDHNLQ---LCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTR 232
D + +C + R + + KGDSGGPL+C GV +G+V+ G + K P ++TR
Sbjct: 183 THHDGAITERLMCAESNR--RDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR 240
Query: 233 ISHYRPWINQIL 244
++ Y WI+ +L
Sbjct: 241 VASYAAWIDSVL 252
>gi|5453676 granzyme A precursor [Homo sapiens]
Length = 262
Score = 159 bits (401), Expect = 3e-39
Identities = 92/224 (41%), Positives = 128/224 (57%), Gaps = 14/224 (6%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHC-AGRSITVTLGAH 79
+IIGG E PHSRPYM L + C G LI +++VLTAAHC + V LGAH
Sbjct: 28 KIIGGNEVTPHSRPYMVLLSLDRKT----ICAGALIAKDWVLTAAHCNLNKRSQVILGAH 83
Query: 80 NITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVP 139
+IT EE T Q + V K+F +P Y+ +T D+ LL+L EKA + V L P + + V
Sbjct: 84 SITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
Query: 140 PGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHN-----LQLCVGNPRK 194
PG MC+VAGWGRT SDTL+EV + ++D + C+ ++ N +C G+ R
Sbjct: 144 PGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRG 203
Query: 195 TKSAFKGDSGGPLLCAGVAQGIVSYGR----SDAKPPAVFTRIS 234
+ + GDSG PLLC GV +G+ S+G D + P V+ +S
Sbjct: 204 GRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLS 247
>gi|21327705 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 155 bits (391), Expect = 4e-38
Identities = 95/256 (37%), Positives = 135/256 (52%), Gaps = 22/256 (8%)
Query: 2 LLLPLPLLLFLLC-----SRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLI 56
LLLPL +LL L A+ +II G C S P+ ++ +G CGG L+
Sbjct: 5 LLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPW----QVALLSGNQLHCGGVLV 60
Query: 57 RRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKL 116
+VLTAAHC TV LG+ + + Q+++ K FRHP Y+T T +D+ML+KL
Sbjct: 61 NERWVLTAAHCKMNEYTVHLGSDTLGDRRA--QRIKASKSFRHPGYSTQTHVNDLMLVKL 118
Query: 117 KEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRT---GVLKPGSDTLQEVKLRLMDPQ 173
+A L+ V + PS+ PPG C V+GWG T V P L V ++L+ PQ
Sbjct: 119 NSQARLSSMVKKVRLPSRCE--PPGTTCTVSGWGTTTSPDVTFPSD--LMCVDVKLISPQ 174
Query: 174 ACSH-FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAV 229
C+ ++D N LC G P K+A GDSGGPL+C G QG+VS+G P V
Sbjct: 175 DCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGV 234
Query: 230 FTRISHYRPWINQILQ 245
+T++ + WIN ++
Sbjct: 235 YTQVCKFTKWINDTMK 250
>gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 155 bits (391), Expect = 4e-38
Identities = 95/256 (37%), Positives = 135/256 (52%), Gaps = 22/256 (8%)
Query: 2 LLLPLPLLLFLLC-----SRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLI 56
LLLPL +LL L A+ +II G C S P+ ++ +G CGG L+
Sbjct: 5 LLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPW----QVALLSGNQLHCGGVLV 60
Query: 57 RRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKL 116
+VLTAAHC TV LG+ + + Q+++ K FRHP Y+T T +D+ML+KL
Sbjct: 61 NERWVLTAAHCKMNEYTVHLGSDTLGDRRA--QRIKASKSFRHPGYSTQTHVNDLMLVKL 118
Query: 117 KEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRT---GVLKPGSDTLQEVKLRLMDPQ 173
+A L+ V + PS+ PPG C V+GWG T V P L V ++L+ PQ
Sbjct: 119 NSQARLSSMVKKVRLPSRCE--PPGTTCTVSGWGTTTSPDVTFPSD--LMCVDVKLISPQ 174
Query: 174 ACSH-FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAV 229
C+ ++D N LC G P K+A GDSGGPL+C G QG+VS+G P V
Sbjct: 175 DCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGV 234
Query: 230 FTRISHYRPWINQILQ 245
+T++ + WIN ++
Sbjct: 235 YTQVCKFTKWINDTMK 250
>gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]
Length = 261
Score = 149 bits (376), Expect = 2e-36
Identities = 97/244 (39%), Positives = 128/244 (52%), Gaps = 26/244 (10%)
Query: 22 IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNI 81
I+GG EC+ HS+P+ V S+G + CGG L+ +VLTAAHC ++ V LG HN+
Sbjct: 25 IVGGWECEKHSQPWQV---AVYSHGWAH-CGGVLVHPQWVLTAAHCLKKNSQVWLGRHNL 80
Query: 82 TEEEDTWQKLEVIKQFRHPKYNTSTL-----------HHDIMLLKLKEKASLTLAVGTLP 130
E EDT Q++ V F HP YN S L HD+MLL+L E A +T V L
Sbjct: 81 FEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLG 140
Query: 131 FPSQFNFVPPGRMCRVAGWGR---TGVLKPGSDTLQEVKLRLMDPQACSH-FRDFDHNLQ 186
P+Q + G C +GWG L+P S LQ V L L+ C+ + +
Sbjct: 141 LPTQEPAL--GTTCYASGWGSIEPEEFLRPRS--LQCVSLHLLSNDMCARAYSEKVTEFM 196
Query: 187 LCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDA---KPPAVFTRISHYRPWINQI 243
LC G K GDSGGPL+C GV QGI S+G + PAV+T++ HYR WI
Sbjct: 197 LCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDT 256
Query: 244 LQAN 247
+ AN
Sbjct: 257 IAAN 260
>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
Length = 305
Score = 144 bits (363), Expect = 7e-35
Identities = 87/239 (36%), Positives = 128/239 (53%), Gaps = 17/239 (7%)
Query: 15 SRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITV 74
SRA+ +++GG EC+PHS+P+ A L G CGG L+ N+VLTAAHC TV
Sbjct: 71 SRAQEDKVLGGHECQPHSQPWQAAL----FQGQQLLCGGVLVGGNWVLTAAHCKKPKYTV 126
Query: 75 TLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTL---HHDIMLLKLKEKASLTLAVGTLPF 131
LG H++ ++ Q++ V++ HP YN+S + +HD+MLL+L+++ASL V P
Sbjct: 127 RLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKV--KPI 184
Query: 132 PSQFNFVPPGRMCRVAGWGR-TGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVG 190
+ PG+ C V+GWG T + DTL ++++ + C +
Sbjct: 185 SLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCA 244
Query: 191 NPRKTKSAFKGDSGGPLLCAGVAQGIVSY-----GRSDAKPPAVFTRISHYRPWINQIL 244
K +GDSGGPL+C G QGI S+ GRSD P V+T I Y WI +I+
Sbjct: 245 GSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSD--KPGVYTNICRYLDWIKKII 301
>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
Length = 260
Score = 144 bits (363), Expect = 7e-35
Identities = 87/239 (36%), Positives = 128/239 (53%), Gaps = 17/239 (7%)
Query: 15 SRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITV 74
SRA+ +++GG EC+PHS+P+ A L G CGG L+ N+VLTAAHC TV
Sbjct: 26 SRAQEDKVLGGHECQPHSQPWQAAL----FQGQQLLCGGVLVGGNWVLTAAHCKKPKYTV 81
Query: 75 TLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTL---HHDIMLLKLKEKASLTLAVGTLPF 131
LG H++ ++ Q++ V++ HP YN+S + +HD+MLL+L+++ASL V P
Sbjct: 82 RLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKV--KPI 139
Query: 132 PSQFNFVPPGRMCRVAGWGR-TGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVG 190
+ PG+ C V+GWG T + DTL ++++ + C +
Sbjct: 140 SLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCA 199
Query: 191 NPRKTKSAFKGDSGGPLLCAGVAQGIVSY-----GRSDAKPPAVFTRISHYRPWINQIL 244
K +GDSGGPL+C G QGI S+ GRSD P V+T I Y WI +I+
Sbjct: 200 GSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSD--KPGVYTNICRYLDWIKKII 256
>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
Length = 304
Score = 141 bits (356), Expect = 5e-34
Identities = 89/235 (37%), Positives = 121/235 (51%), Gaps = 19/235 (8%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHN 80
+I+GG C+ +S PY V+ N S FCGG LI +V++AAHC I V LG HN
Sbjct: 80 KIVGGYTCEENSLPYQ-----VSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHN 134
Query: 81 ITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPP 140
I E Q + K RHPKYN TL +DIML+KL A + V T+ P+ PP
Sbjct: 135 IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPT----APP 190
Query: 141 --GRMCRVAGWGRTGVLKPGSDTLQEVKLR----LMDPQACSHFRDFDHNLQLCVGNPRK 194
G C ++GWG T L G+D E+K L + + + N CVG
Sbjct: 191 AAGTECLISGWGNT--LSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEG 248
Query: 195 TKSAFKGDSGGPLLCAGVAQGIVSYGRSDA--KPPAVFTRISHYRPWINQILQAN 247
K + + DSGGP++C G QG+VS+G A P V+T++ +Y WI + AN
Sbjct: 249 GKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAAN 303
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 141 bits (356), Expect = 5e-34
Identities = 89/235 (37%), Positives = 121/235 (51%), Gaps = 19/235 (8%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHN 80
+I+GG C+ +S PY V+ N S FCGG LI +V++AAHC I V LG HN
Sbjct: 23 KIVGGYTCEENSLPYQ-----VSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHN 77
Query: 81 ITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPP 140
I E Q + K RHPKYN TL +DIML+KL A + V T+ P+ PP
Sbjct: 78 IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPT----APP 133
Query: 141 --GRMCRVAGWGRTGVLKPGSDTLQEVKLR----LMDPQACSHFRDFDHNLQLCVGNPRK 194
G C ++GWG T L G+D E+K L + + + N CVG
Sbjct: 134 AAGTECLISGWGNT--LSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEG 191
Query: 195 TKSAFKGDSGGPLLCAGVAQGIVSYGRSDA--KPPAVFTRISHYRPWINQILQAN 247
K + + DSGGP++C G QG+VS+G A P V+T++ +Y WI + AN
Sbjct: 192 GKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAAN 246
>gi|4502173 prostate specific antigen isoform 1 preproprotein [Homo
sapiens]
Length = 261
Score = 141 bits (355), Expect = 6e-34
Identities = 91/244 (37%), Positives = 122/244 (50%), Gaps = 26/244 (10%)
Query: 22 IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNI 81
I+GG EC+ HS+P+ +V S G + CGG L+ +VLTAAHC + LG H++
Sbjct: 25 IVGGWECEKHSQPWQV---LVASRGRA-VCGGVLVHPQWVLTAAHCIRNKSVILLGRHSL 80
Query: 82 TEEEDTWQKLEVIKQFRHPKYNTSTL-----------HHDIMLLKLKEKASLTLAVGTLP 130
EDT Q +V F HP Y+ S L HD+MLL+L E A LT AV +
Sbjct: 81 FHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMD 140
Query: 131 FPSQFNFVPPGRMCRVAGWGR---TGVLKPGSDTLQEVKLRLMDPQACSHFRDFD-HNLQ 186
P+Q + G C +GWG L P LQ V L ++ C+
Sbjct: 141 LPTQEPAL--GTTCYASGWGSIEPEEFLTP--KKLQCVDLHVISNDVCAQVHPQKVTKFM 196
Query: 187 LCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDA---KPPAVFTRISHYRPWINQI 243
LC G KS GDSGGPL+C GV QGI S+G + P+++T++ HYR WI
Sbjct: 197 LCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDT 256
Query: 244 LQAN 247
+ AN
Sbjct: 257 IVAN 260
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 139 bits (349), Expect = 3e-33
Identities = 92/256 (35%), Positives = 133/256 (51%), Gaps = 25/256 (9%)
Query: 5 PLPLLLFLLCSRA----EAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF 60
PL +L F+ + A + +I+GG C+ +S PY V+ N FCGG LI +
Sbjct: 3 PLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQ-----VSLNSGYHFCGGSLINEQW 57
Query: 61 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA 120
V++A HC I V LG HNI E Q + K RHP+Y+ TL++DIML+KL +A
Sbjct: 58 VVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRA 117
Query: 121 SLTLAVGTLPFPSQFNFVPP--GRMCRVAGWGRT---GVLKPGSDTLQEVKLRLMDPQAC 175
+ V T+ P+ PP G C ++GWG T G P D LQ + ++ C
Sbjct: 118 VINARVSTISLPT----APPATGTKCLISGWGNTASSGADYP--DELQCLDAPVLSQAKC 171
Query: 176 --SHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAK--PPAVFT 231
S+ N+ CVG K + +GDSGGP++C G QG+VS+G A+ P V+T
Sbjct: 172 EASYPGKITSNM-FCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYT 230
Query: 232 RISHYRPWINQILQAN 247
++ +Y WI + AN
Sbjct: 231 KVYNYVKWIKNTIAAN 246
>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
Length = 267
Score = 138 bits (347), Expect = 5e-33
Identities = 90/255 (35%), Positives = 135/255 (52%), Gaps = 18/255 (7%)
Query: 1 MLLLPLPLLLFLLC-SRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSK--FCGGFLIR 57
+LL L +L + S+ + +IIGG C S+P+ A L GP + CGG L+
Sbjct: 19 LLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLA----GPRRRFLCGGALLS 74
Query: 58 RNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLK 117
+V+TAAHC + V LG HN+ E T Q L V++Q HP YN+ T +D+MLL+L+
Sbjct: 75 GQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQ 134
Query: 118 EKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGR-TGVLKPGSDTLQEVKLRLMDPQACS 176
+ A + AV P PG CRV+GWG + + +LQ V + + + C
Sbjct: 135 QPARIGRAV--RPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQ 192
Query: 177 HFRDFDHNL---QLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSD-AKP--PAVF 230
+ + + +C G P+ K + +GDSGGPL+C G QG+VS+G A P P V+
Sbjct: 193 --KAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVY 250
Query: 231 TRISHYRPWINQILQ 245
T + YR WI + ++
Sbjct: 251 TNLCKYRSWIEETMR 265
>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
sapiens]
Length = 254
Score = 136 bits (343), Expect = 1e-32
Identities = 84/234 (35%), Positives = 123/234 (52%), Gaps = 16/234 (6%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHN 80
+II G +C PHS+P+ A L V N FC G L+ +VL+AAHC S T+ LG H+
Sbjct: 30 QIINGEDCSPHSQPWQAAL--VMEN--ELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHS 85
Query: 81 I-TEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVP 139
+ ++E Q +E RHP+YN L +D+ML+KL E S + + ++ SQ
Sbjct: 86 LEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTA- 144
Query: 140 PGRMCRVAGWGRTGVLKPGS--DTLQEVKLRLMDPQACSHFRD-FDHNLQLCVGNPRKTK 196
G C V+GWG +L G LQ V + ++ + CS D H C G K
Sbjct: 145 -GNSCLVSGWG---LLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQK 200
Query: 197 SAFKGDSGGPLLCAGVAQGIVSYGRS---DAKPPAVFTRISHYRPWINQILQAN 247
+ GDSGGPL+C G QG+VS+G++ P V+T + + WI + +QA+
Sbjct: 201 DSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS 254
>gi|47551347 protease, serine-like 1 [Homo sapiens]
Length = 283
Score = 135 bits (341), Expect = 3e-32
Identities = 89/235 (37%), Positives = 121/235 (51%), Gaps = 14/235 (5%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAG----RSITVTL 76
+IIGG E PHSRPYMA + G CGGFL+R +V++AAHC R+ V L
Sbjct: 33 QIIGGHEVTPHSRPYMASVRF----GGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVL 88
Query: 77 GAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFN 136
GAH ++ E T Q + HP Y+ T +DI LL+L A L AVG L P +
Sbjct: 89 GAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRA 148
Query: 137 FVP-PGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHFRDFDHNLQLCVGNPRK 194
P G CRVAGWG + L E K+R++DP C S ++ LC +
Sbjct: 149 RPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDS 208
Query: 195 TKSAF-KGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISHYRPWINQILQ 245
+ F DSGGPL+C A G+VS+ D K P V+T++S + WI +++
Sbjct: 209 HRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVR 263
>gi|4504235 granzyme K precursor [Homo sapiens]
Length = 264
Score = 135 bits (340), Expect = 3e-32
Identities = 93/239 (38%), Positives = 131/239 (54%), Gaps = 21/239 (8%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCA-----GRSITVT 75
EIIGG E PHSRP+MA ++ G CGG LI +VLTAAHC G+S TV
Sbjct: 26 EIIGGKEVSPHSRPFMASIQY----GGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVV 81
Query: 76 LGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQF 135
LGAH++++ E + Q LE+ K + + +DIML+KL+ A L V L S+
Sbjct: 82 LGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKT 141
Query: 136 NFVPPGRMCRVAGWGRTGV--LKPGSDTLQEVKLRLMDPQAC---SHFRD--FDHNLQLC 188
+ + G C+V GWG T L+P SDTL+EV + ++ + C S++ F +C
Sbjct: 142 S-LRSGTKCKVTGWGATDPDSLRP-SDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVC 199
Query: 189 VGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR--SDAKPPAVFTRIS-HYRPWINQIL 244
G+ + K + KGDSGGPL+C GV IVS G A P ++T ++ Y+ WI L
Sbjct: 200 AGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNL 258
>gi|11496281 kallikrein 13 precursor [Homo sapiens]
Length = 277
Score = 135 bits (339), Expect = 4e-32
Identities = 88/243 (36%), Positives = 121/243 (49%), Gaps = 14/243 (5%)
Query: 12 LLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRS 71
+L + +G + GG C PHS+P+ A L + CGG L+ +VLTAAHC
Sbjct: 26 VLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGR----LLCGGVLVHPKWVLTAAHCLKEG 81
Query: 72 ITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLH----HDIMLLKLKEKASLTLAVG 127
+ V LG H + E Q EV+ HP+Y S H HDIMLL+L+ LT +
Sbjct: 82 LKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQ 141
Query: 128 TLPFPSQFNFVPPGRMCRVAGWGRTGVLKPG-SDTLQEVKLRLMDPQACSH-FRDFDHNL 185
TLP S N + PG CRV+GWG T + TLQ ++L + C + +
Sbjct: 142 TLPL-SHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDN 200
Query: 186 QLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISHYRPWINQ 242
LC G K + +GDSGGPL+C GIVS+G P V+TR+S Y WI +
Sbjct: 201 MLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRE 260
Query: 243 ILQ 245
++
Sbjct: 261 TIR 263
>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
[Homo sapiens]
Length = 256
Score = 133 bits (334), Expect = 2e-31
Identities = 85/257 (33%), Positives = 129/257 (50%), Gaps = 25/257 (9%)
Query: 9 LLFLLCSRA--EAGEIIGGTECKPHSRPY-MAYLEIVTSNGPSKFCGGFLIRRNFVLTAA 65
L FLL S A + +++ G EC PHS+P+ +A E N CG LI ++VL+AA
Sbjct: 7 LSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGRFN-----CGASLISPHWVLSAA 61
Query: 66 HCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLA 125
HC R + V LG HN+ + + Q + HP+Y + +DIMLL+L + A L
Sbjct: 62 HCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQ 121
Query: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGS-----------DTLQEVKLRLMDPQA 174
V P++ PG C V+GWG +PG+ DTL + ++ +
Sbjct: 122 VRPAVLPTRCPH--PGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTS 179
Query: 175 C-SHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVF 230
C + N +C G + + +GDSGGPL+C G+ QGIVS+G + P V+
Sbjct: 180 CDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVY 239
Query: 231 TRISHYRPWINQILQAN 247
T++ HY WI + ++ N
Sbjct: 240 TKVCHYLEWIRETMKRN 256
>gi|4504875 kallikrein 1 preproprotein [Homo sapiens]
Length = 262
Score = 131 bits (330), Expect = 5e-31
Identities = 88/247 (35%), Positives = 129/247 (52%), Gaps = 31/247 (12%)
Query: 22 IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNI 81
I+GG EC+ HS+P+ A L ++ CGG L+ R +VLTAAHC + + LG HN+
Sbjct: 25 IVGGWECEQHSQPWQAALYHFSTFQ----CGGILVHRQWVLTAAHCISDNYQLWLGRHNL 80
Query: 82 TEEEDTWQKLEVIKQFRHPKYNTSTLH-----------HDIMLLKLKEKA-SLTLAVGTL 129
++E+T Q + V + F HP +N S L HD+MLL+L E A ++T AV +
Sbjct: 81 FDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVV 140
Query: 130 PFPSQFNFVPPGRMCRVAGWGRTGVLKPGS----DTLQEVKLRLMDPQAC--SHFRDFDH 183
P++ V G C +GWG ++P + D LQ V L+++ C +H +
Sbjct: 141 ELPTEEPEV--GSTCLASGWGS---IEPENFSFPDDLQCVDLKILPNDECKKAHVQKVT- 194
Query: 184 NLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISHYRPWI 240
+ LCVG+ K GDSGGPL+C GV QG+ S+G P+V R+ Y WI
Sbjct: 195 DFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWI 254
Query: 241 NQILQAN 247
+ N
Sbjct: 255 EDTIAEN 261
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 128 bits (322), Expect = 4e-30
Identities = 84/235 (35%), Positives = 118/235 (50%), Gaps = 19/235 (8%)
Query: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHN 80
+I+GG C+ +S PY V+ N FCGG LI +V++A HC I V LG HN
Sbjct: 23 KIVGGYICEENSVPYQ-----VSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHN 77
Query: 81 ITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPP 140
I E Q + K RHPKYN+ TL +DI+L+KL A + V + P+ PP
Sbjct: 78 IEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPT----APP 133
Query: 141 --GRMCRVAGWGRTGVLKPGSDTLQEVKLR----LMDPQACSHFRDFDHNLQLCVGNPRK 194
G ++GWG T L G+D E++ L + + + N CVG
Sbjct: 134 AAGTESLISGWGNT--LSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEG 191
Query: 195 TKSAFKGDSGGPLLCAGVAQGIVS--YGRSDAKPPAVFTRISHYRPWINQILQAN 247
K + +GDSGGP++ G QGIVS YG + P V+T++ +Y WI + AN
Sbjct: 192 GKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAAN 246
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 126 bits (316), Expect = 2e-29
Identities = 82/251 (32%), Positives = 124/251 (49%), Gaps = 13/251 (5%)
Query: 1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF 60
M L + L L E +++ G C S PY A L TS CGG LI +
Sbjct: 1 MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAAL--YTSG--HLLCGGVLIHPLW 56
Query: 61 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA 120
VLTAAHC ++ V LG HN+ + E + ++ V++ HP Y+ ++ DIMLL+L A
Sbjct: 57 VLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPA 116
Query: 121 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF-- 178
L+ + P P + + C + GWG+T DT+Q + L+ + C H
Sbjct: 117 KLSELI--QPLPLERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECEHAYP 173
Query: 179 RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISH 235
N+ LC G+ + K + +GDSGGPL+C +G+VS+G + P V+T +
Sbjct: 174 GQITQNM-LCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCR 232
Query: 236 YRPWINQILQA 246
Y WI + +QA
Sbjct: 233 YTNWIQKTIQA 243
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 126 bits (316), Expect = 2e-29
Identities = 82/251 (32%), Positives = 124/251 (49%), Gaps = 13/251 (5%)
Query: 1 MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF 60
M L + L L E +++ G C S PY A L TS CGG LI +
Sbjct: 1 MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAAL--YTSG--HLLCGGVLIHPLW 56
Query: 61 VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA 120
VLTAAHC ++ V LG HN+ + E + ++ V++ HP Y+ ++ DIMLL+L A
Sbjct: 57 VLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPA 116
Query: 121 SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHF-- 178
L+ + P P + + C + GWG+T DT+Q + L+ + C H
Sbjct: 117 KLSELI--QPLPLERDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECEHAYP 173
Query: 179 RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISH 235
N+ LC G+ + K + +GDSGGPL+C +G+VS+G + P V+T +
Sbjct: 174 GQITQNM-LCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCR 232
Query: 236 YRPWINQILQA 246
Y WI + +QA
Sbjct: 233 YTNWIQKTIQA 243
>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 125 bits (315), Expect = 3e-29
Identities = 86/253 (33%), Positives = 127/253 (50%), Gaps = 17/253 (6%)
Query: 6 LPLLLFLLCSRAEAGE--IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLT 63
L L+L L + GE II G ECKPHS+P+ A L T CG LI ++LT
Sbjct: 4 LQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTR----LLCGATLIAPRWLLT 59
Query: 64 AAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLH----HDIMLLKLKEK 119
AAHC V LG HN+ +EE Q + F HP +N S + +DIML+K+
Sbjct: 60 AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 119
Query: 120 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPG-SDTLQEVKLRLMDPQACSH- 177
S+T AV L S+ V G C ++GWG T + TL+ + +++ Q C +
Sbjct: 120 VSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 177
Query: 178 FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSD---AKPPAVFTRIS 234
+ + +C K + +GDSGGPL+C QGI+S+G+ + P V+T++
Sbjct: 178 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 237
Query: 235 HYRPWINQILQAN 247
Y WI + ++ N
Sbjct: 238 KYVDWIQETMKNN 250
>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
Length = 282
Score = 125 bits (315), Expect = 3e-29
Identities = 86/253 (33%), Positives = 127/253 (50%), Gaps = 17/253 (6%)
Query: 6 LPLLLFLLCSRAEAGE--IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLT 63
L L+L L + GE II G ECKPHS+P+ A L T CG LI ++LT
Sbjct: 36 LQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTR----LLCGATLIAPRWLLT 91
Query: 64 AAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLH----HDIMLLKLKEK 119
AAHC V LG HN+ +EE Q + F HP +N S + +DIML+K+
Sbjct: 92 AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 151
Query: 120 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPG-SDTLQEVKLRLMDPQACSH- 177
S+T AV L S+ V G C ++GWG T + TL+ + +++ Q C +
Sbjct: 152 VSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 209
Query: 178 FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSD---AKPPAVFTRIS 234
+ + +C K + +GDSGGPL+C QGI+S+G+ + P V+T++
Sbjct: 210 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 269
Query: 235 HYRPWINQILQAN 247
Y WI + ++ N
Sbjct: 270 KYVDWIQETMKNN 282
>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 125 bits (315), Expect = 3e-29
Identities = 86/253 (33%), Positives = 127/253 (50%), Gaps = 17/253 (6%)
Query: 6 LPLLLFLLCSRAEAGE--IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLT 63
L L+L L + GE II G ECKPHS+P+ A L T CG LI ++LT
Sbjct: 4 LQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTR----LLCGATLIAPRWLLT 59
Query: 64 AAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLH----HDIMLLKLKEK 119
AAHC V LG HN+ +EE Q + F HP +N S + +DIML+K+
Sbjct: 60 AAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASP 119
Query: 120 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPG-SDTLQEVKLRLMDPQACSH- 177
S+T AV L S+ V G C ++GWG T + TL+ + +++ Q C +
Sbjct: 120 VSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 177
Query: 178 FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSD---AKPPAVFTRIS 234
+ + +C K + +GDSGGPL+C QGI+S+G+ + P V+T++
Sbjct: 178 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 237
Query: 235 HYRPWINQILQAN 247
Y WI + ++ N
Sbjct: 238 KYVDWIQETMKNN 250
>gi|22208987 kallikrein 12 isoform 2 [Homo sapiens]
Length = 248
Score = 123 bits (308), Expect = 2e-28
Identities = 88/247 (35%), Positives = 120/247 (48%), Gaps = 13/247 (5%)
Query: 8 LLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHC 67
LL L S+A +I GTEC +S+P+ L G S CGG LI +VLTAAHC
Sbjct: 8 LLCVLGLSQAATPKIFNGTECGRNSQPWQVGL----FEGTSLRCGGVLIDHRWVLTAAHC 63
Query: 68 AGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKY-NTSTLH-HDIMLLKLKEKASLTLA 125
+G V LG H++++ + T Q HP Y ST H HD+ LL+L+ +T +
Sbjct: 64 SGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTSS 123
Query: 126 VGTLPFPSQFNFVPPGRMCRVAGWGRTG-VLKPGSDTLQEVKLRLMDPQACSHFRDFDHN 184
V LP P+ + G C V+GWG T P D LQ + L ++ C
Sbjct: 124 VQPLPLPN--DCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPGRIT 181
Query: 185 LQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR----SDAKPPAVFTRISHYRPWI 240
+ + A +GDSGGPL+C GV QG+VS+G P V+T I Y WI
Sbjct: 182 SNMVCAGGVPGQDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYICKYVDWI 241
Query: 241 NQILQAN 247
I++ N
Sbjct: 242 RMIMRNN 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,671,788
Number of Sequences: 37866
Number of extensions: 475142
Number of successful extensions: 1447
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 822
Number of HSP's gapped (non-prelim): 196
length of query: 247
length of database: 18,247,518
effective HSP length: 100
effective length of query: 147
effective length of database: 14,460,918
effective search space: 2125754946
effective search space used: 2125754946
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.