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Search of human proteins with 4502527
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
(2181 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 4423 0.0
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 4344 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 4276 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 2752 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 2746 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 2745 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 2744 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 2744 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 2739 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 2739 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 2739 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 2736 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 2734 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 2733 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 2733 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 2731 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 2727 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 2727 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 2726 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 2726 0.0
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 2379 0.0
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 2269 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 773 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 765 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 761 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 727 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 420 e-117
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 4423 bits (11472), Expect = 0.0
Identities = 2181/2181 (100%), Positives = 2181/2181 (100%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV
Sbjct: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
Query: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
Sbjct: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
Query: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
Sbjct: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
Query: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
Sbjct: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
Query: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
Sbjct: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Query: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
Sbjct: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
Query: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
Sbjct: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
Query: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
Sbjct: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
Query: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
Sbjct: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
Query: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
Sbjct: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
Query: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP
Sbjct: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
Query: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
Sbjct: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
Query: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
Sbjct: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
Query: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP
Sbjct: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
Query: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
Sbjct: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
Query: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
Sbjct: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
Query: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
Sbjct: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
Query: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
Sbjct: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
Query: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
Sbjct: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
Query: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
Sbjct: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
Query: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
Sbjct: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
Query: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV
Sbjct: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
Query: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL
Sbjct: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
Query: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
Sbjct: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
Query: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA
Sbjct: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
Query: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH
Sbjct: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
Query: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
Sbjct: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
Query: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE
Sbjct: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
Query: 2161 EPDPGRDEEDLADEMICITTL 2181
EPDPGRDEEDLADEMICITTL
Sbjct: 2161 EPDPGRDEEDLADEMICITTL 2181
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 4344 bits (11266), Expect = 0.0
Identities = 2154/2181 (98%), Positives = 2158/2181 (98%), Gaps = 20/2181 (0%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYW+NDA+G+E PWVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
GEGENRGCCGSL QAISKSKLSRRWRRWNRFNRRRCRAAV
Sbjct: 481 GEGENRGCCGSLC--------------------QAISKSKLSRRWRRWNRFNRRRCRAAV 520
Query: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
Sbjct: 521 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
Query: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
Query: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 700
Query: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
Sbjct: 701 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
Query: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
Sbjct: 761 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 820
Query: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
Sbjct: 821 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 880
Query: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
Sbjct: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 940
Query: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
Sbjct: 941 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1000
Query: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
Sbjct: 1001 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1060
Query: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP
Sbjct: 1061 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1120
Query: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
Sbjct: 1121 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1180
Query: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
Sbjct: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
Query: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP
Sbjct: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1300
Query: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
Sbjct: 1301 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360
Query: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
Sbjct: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1420
Query: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
Sbjct: 1421 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1480
Query: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
Sbjct: 1481 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1540
Query: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
Sbjct: 1541 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1600
Query: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
Sbjct: 1601 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1660
Query: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
Sbjct: 1661 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1720
Query: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV
Sbjct: 1721 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1780
Query: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL
Sbjct: 1781 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1840
Query: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
Sbjct: 1841 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1900
Query: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA
Sbjct: 1901 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1960
Query: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH
Sbjct: 1961 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2020
Query: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
Sbjct: 2021 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2080
Query: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE
Sbjct: 2081 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2140
Query: 2161 EPDPGRDEEDLADEMICITTL 2181
EPDPGRDEEDLADEMICITTL
Sbjct: 2141 EPDPGRDEEDLADEMICITTL 2161
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 4276 bits (11089), Expect = 0.0
Identities = 2130/2181 (97%), Positives = 2134/2181 (97%), Gaps = 44/2181 (2%)
Query: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
Sbjct: 1 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
Query: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
Sbjct: 61 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
Query: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
Sbjct: 121 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI 180
Query: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
Sbjct: 181 IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR 240
Query: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
Sbjct: 241 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
Query: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
Sbjct: 301 CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
ITMEGWTDVLYW+NDA+G+E PWVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARG
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480
Query: 481 GEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540
GEGENRGCCGSL QAISKSKLSRRWRRWNRFNRRRCRAAV
Sbjct: 481 GEGENRGCCGSLC--------------------QAISKSKLSRRWRRWNRFNRRRCRAAV 520
Query: 541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 600
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
Sbjct: 521 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ 580
Query: 601 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 660
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
Query: 661 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 720
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ 700
Query: 721 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
Sbjct: 701 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
Query: 781 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 840
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP
Sbjct: 761 LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPP 820
Query: 841 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 900
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
Sbjct: 821 CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH 880
Query: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 960
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
Sbjct: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT 940
Query: 961 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1020
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
Sbjct: 941 FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG 1000
Query: 1021 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1080
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
Sbjct: 1001 LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI 1060
Query: 1081 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1140
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP
Sbjct: 1061 LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGP 1120
Query: 1141 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1200
IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
Sbjct: 1121 IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL 1180
Query: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
Sbjct: 1181 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1240
Query: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD
Sbjct: 1241 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD---------- 1290
Query: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
Sbjct: 1291 -----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1345
Query: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
Sbjct: 1346 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1405
Query: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1500
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
Sbjct: 1406 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1465
Query: 1501 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1560
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
Sbjct: 1466 HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1525
Query: 1561 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1620
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
Sbjct: 1526 DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE 1585
Query: 1621 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1680
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
Sbjct: 1586 VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC 1645
Query: 1681 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1740
DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
Sbjct: 1646 DLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP 1705
Query: 1741 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1800
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV
Sbjct: 1706 ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHV 1765
Query: 1801 SENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCL 1860
SENGHHSSHKHDREPQRRSSVK RSDSGDEQLPTICREDPEIHGYFRDPHCL
Sbjct: 1766 SENGHHSSHKHDREPQRRSSVK---------RSDSGDEQLPTICREDPEIHGYFRDPHCL 1816
Query: 1861 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1920
GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
Sbjct: 1817 GEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY 1876
Query: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA
Sbjct: 1877 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1936
Query: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH
Sbjct: 1937 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 1996
Query: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF
Sbjct: 1997 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2056
Query: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE
Sbjct: 2057 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2116
Query: 2161 EPDPGRDEEDLADEMICITTL 2181
EPDPGRDEEDLADEMICITTL
Sbjct: 2117 EPDPGRDEEDLADEMICITTL 2137
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 2752 bits (7133), Expect = 0.0
Identities = 1464/2185 (67%), Positives = 1682/2185 (76%), Gaps = 115/2185 (5%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHH----SSHKHDR 1813
+++S T +NAN+NNAN + RP+ G VS H S +
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA-GYPSTVSTVEGHGPPLSPAIRVQ 1805
Query: 1814 EPQRRSSVKRTRYY----ETYIRSDSGDEQLPTIC----REDPEIHGYFRDPHCLGEQEY 1865
E + S R R+ + +R DSG C + +P + QE
Sbjct: 1806 EVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEE 1865
Query: 1866 FSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSE--RPRGYHHPQGFLEDDDSPVCYDSR 1923
S +E YE + N+ + + +E + + Q L ++D D R
Sbjct: 1866 TSQDETYE-------VKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDK---RDIR 1915
Query: 1924 RSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAG 1983
+SP+R L + + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAG
Sbjct: 1916 QSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAG 1969
Query: 1984 LDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSS 2043
L + +SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H S
Sbjct: 1970 LSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGS 2029
Query: 2044 WYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPK 2099
W P + R P SL VPS SA SLVEAVLISEGLG++A+DPK
Sbjct: 2030 WAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPK 2089
Query: 2100 FVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSD 2159
F+ T E+ADACD+TI+EMESAA +L+G NG + P + +D QD G D
Sbjct: 2090 FIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEED 2148
Query: 2160 EEPDPGR---DEEDLADEMICITTL 2181
R EE+L D + +++L
Sbjct: 2149 AGCVRARGRPSEEELQDSRVYVSSL 2173
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 2746 bits (7119), Expect = 0.0
Identities = 1461/2177 (67%), Positives = 1668/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
SD WN FD LIVIGSIIDV LSE +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 SDPWNVFDFLIVIGSIIDVILSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1802
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1803 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1860
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1861 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1888
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1889 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1942
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1943 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2002
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2003 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2062
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2063 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2121
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2122 RPSEEELQDSRVYVSSL 2138
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 2746 bits (7117), Expect = 0.0
Identities = 1461/2177 (67%), Positives = 1666/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
SD WN FD LIVIGSIIDV LSE +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 SDPWNVFDFLIVIGSIIDVILSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1802
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1803 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1860
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1861 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1888
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1889 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1942
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1943 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2002
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2003 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2062
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2063 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2121
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2122 RPSEEELQDSRVYVSSL 2138
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 2745 bits (7116), Expect = 0.0
Identities = 1457/2177 (66%), Positives = 1670/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1802
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1803 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1860
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1861 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1888
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1889 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1942
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1943 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2002
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2003 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2062
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2063 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2121
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2122 RPSEEELQDSRVYVSSL 2138
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 2744 bits (7114), Expect = 0.0
Identities = 1457/2177 (66%), Positives = 1668/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1802
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1803 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1860
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1861 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1888
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1889 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1942
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1943 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2002
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2003 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2062
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2063 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2121
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2122 RPSEEELQDSRVYVSSL 2138
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 2744 bits (7114), Expect = 0.0
Identities = 1461/2175 (67%), Positives = 1664/2175 (76%), Gaps = 133/2175 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFADSDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNFDN 349
ELF+GKMHKTC+ + I AE+DP+PCA +G+GRQC NGT C+ GW GP GITNFDN
Sbjct: 288 ELFMGKMHKTCYNQEG-IAAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDN 345
Query: 350 FAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
FAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSGEF
Sbjct: 346 FAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405
Query: 410 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSMPT 468
SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SMPT
Sbjct: 406 SKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 465
Query: 469 SETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRW 525
SETESVNTENV+G EGEN CG+ R ISKSK SR W
Sbjct: 466 SETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSRYW 503
Query: 526 RRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLAL 585
RRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LLAL
Sbjct: 504 RRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL 563
Query: 586 FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645
FT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRLLR
Sbjct: 564 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLR 623
Query: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKR 705
IFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT+R
Sbjct: 624 IFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRR 683
Query: 706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 765
STFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYILLN
Sbjct: 684 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 743
Query: 766 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD--- 820
VFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 744 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIEL 803
Query: 821 ------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRR 867
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRPR
Sbjct: 804 KSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRPRP 858
Query: 868 ISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED 927
+SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAAED
Sbjct: 859 LSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED 918
Query: 928 PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL 987
P++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV VSL
Sbjct: 919 PVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSL 978
Query: 988 VSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQF 1047
+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLLQF
Sbjct: 979 ISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQF 1038
Query: 1048 MFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNV 1107
MFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FDNV
Sbjct: 1039 MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV 1098
Query: 1108 LSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIF 1167
L+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMNIF
Sbjct: 1099 LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF 1158
Query: 1168 VGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPF 1227
VGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+ F
Sbjct: 1159 VGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYF 1218
Query: 1228 EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSD 1287
EY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYFSD
Sbjct: 1219 EYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSD 1278
Query: 1288 AWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLV 1347
WN FD LIVIGSIIDV LSE +P E + N+EE++RISITFFRLFRVMRLV
Sbjct: 1279 PWNVFDFLIVIGSIIDVILSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLV 1334
Query: 1348 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN 1407
KLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNN
Sbjct: 1335 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN 1394
Query: 1408 NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFI 1465
NFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFI
Sbjct: 1395 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1454
Query: 1466 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDV 1525
SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDV
Sbjct: 1455 SFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDV 1514
Query: 1526 VTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGN 1585
VTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGN
Sbjct: 1515 VTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN 1574
Query: 1586 LEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQ 1645
LEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQ
Sbjct: 1575 LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQ 1634
Query: 1646 GLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVF 1699
GLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F
Sbjct: 1635 GLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIF 1693
Query: 1700 KRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHN 1759
+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1694 RRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FT 1751
Query: 1760 HHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRS 1819
+++S T +NAN+NNAN + RP+ + S H P R
Sbjct: 1752 PSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR- 1800
Query: 1820 SVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYE 1873
V+ + + R S + Q +E+ + D E S+E Y+
Sbjct: 1801 -VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQ 1859
Query: 1874 DDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPP 1933
DD + Q L ++D D R+SP+R L
Sbjct: 1860 DD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL-R 1886
Query: 1934 TPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYS 1993
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +S
Sbjct: 1887 SASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHS 1941
Query: 1994 PSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP---- 2049
P+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1942 PASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGG 2001
Query: 2050 DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIA 2109
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+A
Sbjct: 2002 SSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELA 2061
Query: 2110 DACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR--- 2166
DACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2062 DACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRP 2120
Query: 2167 DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2121 SEEELQDSRVYVSSL 2135
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 2739 bits (7101), Expect = 0.0
Identities = 1456/2177 (66%), Positives = 1668/2177 (76%), Gaps = 134/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYW+ DA+G+E PWVYFVSL+I GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1576 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1636 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1694
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1695 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1752
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1753 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1802
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1803 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1860
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1861 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1888
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1889 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1942
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1943 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 2002
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 2003 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2062
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2063 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2121
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2122 RPSEEELQDSRVYVSSL 2138
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 2739 bits (7100), Expect = 0.0
Identities = 1455/2177 (66%), Positives = 1667/2177 (76%), Gaps = 145/2177 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVN---------------NAEENSRISITFFRLFRVMR 1324
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1325 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1384
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1385 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1444
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1445 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1504
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1505 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1564
Query: 1584 GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1643
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRK
Sbjct: 1565 GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1624
Query: 1644 EQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDD 1697
EQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E E EDD
Sbjct: 1625 EQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDD 1683
Query: 1698 VFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVC 1757
+F+R G L GNHV++ SD R + QT TT RPLH+ + DTE P +S
Sbjct: 1684 IFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST- 1741
Query: 1758 HNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQR 1817
+++S T +NAN+NNAN + RP+ + S H P
Sbjct: 1742 FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAI 1791
Query: 1818 RSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-C 1871
R V+ + + R S + Q +E+ + D E S+E
Sbjct: 1792 R--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLS 1849
Query: 1872 YEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL 1931
Y+DD + Q L ++D D R+SP+R L
Sbjct: 1850 YQDD-----------------------------ENRQLTLPEEDK---RDIRQSPKRGFL 1877
Query: 1932 PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQK 1991
+ + RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL +
Sbjct: 1878 -RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRS 1931
Query: 1992 YSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP-- 2049
+SP+ R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 1932 HSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGG 1991
Query: 2050 --DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE 2107
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E
Sbjct: 1992 GGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQE 2051
Query: 2108 IADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR- 2166
+ADACD+TI+EMESAA +L+G NG + P + +D QD G D R
Sbjct: 2052 LADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARG 2110
Query: 2167 --DEEDLADEMICITTL 2181
EE+L D + +++L
Sbjct: 2111 RPSEEELQDSRVYVSSL 2127
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 2739 bits (7099), Expect = 0.0
Identities = 1460/2190 (66%), Positives = 1667/2190 (76%), Gaps = 143/2190 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADP-------------TESENVPVPTATPGNSEESNR 1332
SD WN FD LIVIGSIIDV LSE + V + N+EE++R
Sbjct: 1280 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSR 1339
Query: 1333 ISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1392
ISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+F
Sbjct: 1340 ISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1399
Query: 1393 GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE- 1451
GK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ +
Sbjct: 1400 GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTE 1459
Query: 1452 -EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWS 1510
E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+
Sbjct: 1460 GETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWA 1519
Query: 1511 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATL 1570
EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATL
Sbjct: 1520 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATL 1579
Query: 1571 FALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATF 1630
FALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATF
Sbjct: 1580 FALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATF 1639
Query: 1631 LIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDE---- 1686
LIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL +E
Sbjct: 1640 LIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDK 1698
Query: 1687 --PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDT 1744
E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ + DT
Sbjct: 1699 AMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDT 1757
Query: 1745 EKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENG 1804
E P +S +++S T +NAN+NNAN + RP+ + S
Sbjct: 1758 ESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----GYPSTVS 1806
Query: 1805 HHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF-----RDPHC 1859
H P R V+ + + R S + Q +E+ + D
Sbjct: 1807 TVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEA 1864
Query: 1860 LGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPV 1918
E S+E Y+DD + Q L ++D
Sbjct: 1865 CSEPSLLSTEMLSYQDD-----------------------------ENRQLTLPEEDK-- 1893
Query: 1919 CYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQI 1978
D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLHL+ Q
Sbjct: 1894 -RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQA 1946
Query: 1979 MAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPS 2038
+AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++N S PS
Sbjct: 1947 LAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPS 2006
Query: 2039 LHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRY 2094
+H SW P + R P SL VPS SA SLVEAVLISEGLG++
Sbjct: 2007 IHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQF 2066
Query: 2095 ARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFG 2154
A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D QD
Sbjct: 2067 AQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRA 2125
Query: 2155 PGYSDEEPDPGR---DEEDLADEMICITTL 2181
G D R EE+L D + +++L
Sbjct: 2126 GGEEDAGCVRARGRPSEEELQDSRVYVSSL 2155
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 2736 bits (7093), Expect = 0.0
Identities = 1458/2197 (66%), Positives = 1671/2197 (76%), Gaps = 154/2197 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFD--------------------YAFTAIFTVEILLKMTTFGAFL 965
EDP++ SFRN IL YFD Y FT+IFT+EI+LKMT +GAFL
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFL 979
Query: 966 HKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVV 1025
HKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVV
Sbjct: 980 HKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVV 1039
Query: 1026 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDG 1085
QCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG
Sbjct: 1040 QCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG 1099
Query: 1086 DVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHR 1145
+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+R
Sbjct: 1100 EVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYR 1159
Query: 1146 VEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPL 1205
VEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPL
Sbjct: 1160 VEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219
Query: 1206 RRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1265
RRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FT
Sbjct: 1220 RRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1279
Query: 1266 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
G+FTVEM+LK+IAFKPK YF DAWNTFD+LIV+GSI+D+A++E +P E +
Sbjct: 1280 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSM 1335
Query: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYA
Sbjct: 1336 NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1395
Query: 1386 VIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPES 1445
VIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES
Sbjct: 1396 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPES 1455
Query: 1446 DYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 1503
+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLD
Sbjct: 1456 EPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 1515
Query: 1504 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGT 1563
EFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGT
Sbjct: 1516 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGT 1575
Query: 1564 VMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTV 1623
VMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTV
Sbjct: 1576 VMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTV 1635
Query: 1624 GKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQ 1683
GKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1636 GKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLT 1694
Query: 1684 DDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPS 1737
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1695 AEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG 1754
Query: 1738 IPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNL 1797
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1755 -SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA---- 1802
Query: 1798 EHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF--- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1803 GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVK 1860
Query: 1855 --RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFL 1911
D E S+E Y+DD + Q L
Sbjct: 1861 MNHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTL 1891
Query: 1912 EDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPL 1971
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPL
Sbjct: 1892 PEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPL 1942
Query: 1972 HLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQ 2031
HL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ ++
Sbjct: 1943 HLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEK 2002
Query: 2032 VNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLI 2087
+N S PS+H SW P + R P SL VPS SA SLVEAVLI
Sbjct: 2003 LNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLI 2062
Query: 2088 SEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQD 2147
SEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2063 SEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRD 2122
Query: 2148 YELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2123 AG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2158
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 2734 bits (7088), Expect = 0.0
Identities = 1459/2205 (66%), Positives = 1670/2205 (75%), Gaps = 162/2205 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1279
Query: 1286 S----------------------------DAWNTFDSLIVIGSIIDVALSEADPTESENV 1317
S DAWNTFD+LIV+GSI+D+A++E +P E
Sbjct: 1280 SDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH--- 1336
Query: 1318 PVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1377
+ N+EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI
Sbjct: 1337 -TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1395
Query: 1378 AMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP 1437
MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+P
Sbjct: 1396 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1455
Query: 1438 GKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1495
GK C PES+ + E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS
Sbjct: 1456 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1515
Query: 1496 ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMN 1555
ILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MN
Sbjct: 1516 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1575
Query: 1556 MPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPP 1615
MPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA+IKKIWK+TSMKLLDQVVPP
Sbjct: 1576 MPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPP 1635
Query: 1616 AGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIR 1675
AGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIR
Sbjct: 1636 AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIR 1694
Query: 1676 RAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHR 1729
RAIS DL +E E EDD+F+R G L GNHV++ SD R + QT TT R
Sbjct: 1695 RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR 1754
Query: 1730 PLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHG 1789
PLH+ + DTE P +S +++S T +NAN+NNAN +
Sbjct: 1755 PLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRL 1806
Query: 1790 KRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPE 1849
RP+ + S H P R V+ + + R S + Q +E+
Sbjct: 1807 PRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETS 1860
Query: 1850 IHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRG 1903
+ D E S+E Y+DD
Sbjct: 1861 QDETYEVKMNHDTEACSEPSLLSTEMLSYQDD---------------------------- 1892
Query: 1904 YHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIF 1963
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1893 -ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDI 1942
Query: 1964 PHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQV 2023
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++
Sbjct: 1943 SQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRL 2002
Query: 2024 EQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSAD 2079
E E+ +++N S PS+H SW P + R P SL VPS SA
Sbjct: 2003 EGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSAS 2062
Query: 2080 SLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDV 2139
SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG +
Sbjct: 2063 SLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGAL 2122
Query: 2140 GPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
P + +D QD G D R EE+L D + +++L
Sbjct: 2123 LPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2166
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 2734 bits (7087), Expect = 0.0
Identities = 1461/2196 (66%), Positives = 1666/2196 (75%), Gaps = 153/2196 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPKGYF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
SD WN FD LIVIGSIIDV LSE +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 SDPWNVFDFLIVIGSIIDVILSETNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1576 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1635
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1636 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1694
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1695 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1753
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1754 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1802
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1803 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1860
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1861 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1891
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1892 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1942
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1943 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 2002
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 2003 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2062
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2063 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2122
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2123 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2157
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 2734 bits (7086), Expect = 0.0
Identities = 1457/2196 (66%), Positives = 1670/2196 (76%), Gaps = 153/2196 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1576 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1635
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1636 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1694
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1695 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1753
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1754 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1802
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1803 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1860
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1861 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1891
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1892 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1942
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1943 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 2002
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 2003 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2062
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2063 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2122
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2123 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2157
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 2733 bits (7084), Expect = 0.0
Identities = 1467/2233 (65%), Positives = 1685/2233 (75%), Gaps = 163/2233 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFD--------------------YAFTAIFTVEILLKMTTFGAFL 965
EDP++ SFRN IL YFD Y FT+IFT+EI+LKMT +GAFL
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFL 979
Query: 966 HKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVV 1025
HKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVV
Sbjct: 980 HKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVV 1039
Query: 1026 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDG 1085
QCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG
Sbjct: 1040 QCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG 1099
Query: 1086 DVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHR 1145
+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+R
Sbjct: 1100 EVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYR 1159
Query: 1146 VEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPL 1205
VEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPL
Sbjct: 1160 VEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219
Query: 1206 RRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1265
RRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FT
Sbjct: 1220 RRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1279
Query: 1266 GVFTVEMVLKVIAFKPKGYFS----------------------------DAWNTFDSLIV 1297
G+FTVEM+LK+IAFKPKGYFS DAWNTFD+LIV
Sbjct: 1280 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIV 1339
Query: 1298 IGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIR 1357
+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIR
Sbjct: 1340 VGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1395
Query: 1358 TLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVL 1417
TLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVL
Sbjct: 1396 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1455
Query: 1418 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLI 1475
LLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLI
Sbjct: 1456 LLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLI 1515
Query: 1476 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1535
INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPP
Sbjct: 1516 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPP 1575
Query: 1536 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA 1595
LGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA
Sbjct: 1576 LGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRA 1635
Query: 1596 VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN 1655
+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++
Sbjct: 1636 IIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQR 1694
Query: 1656 TTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNH 1709
++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNH
Sbjct: 1695 NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNH 1754
Query: 1710 VNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQ 1769
V++ SD R + QT TT RPLH+ + DTE P +S +++S
Sbjct: 1755 VSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS---- 1808
Query: 1770 VPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHH----SSHKHDREPQRRSSVKRTR 1825
T +NAN+NNAN + RP+ G VS H S +E + S R R
Sbjct: 1809 --TGSNANINNANNTALGRLPRPA-GYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRER 1865
Query: 1826 YY----ETYIRSDSGDEQLPTIC----REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSS 1877
+ + +R DSG C + +P + QE S +E YE
Sbjct: 1866 HVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYE---- 1921
Query: 1878 PTWSRQNYGYYSRYPGRNIDSE--RPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTP 1935
+ N+ + + +E + + Q L ++D D R+SP+R L +
Sbjct: 1922 ---VKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDK---RDIRQSPKRGFL-RSA 1974
Query: 1936 ASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPS 1995
+ RR+SF+ ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+
Sbjct: 1975 SLGRRASFHLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPA 2029
Query: 1996 HSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DI 2051
R +ATPPATP R W P P +++E E+ +++N S PS+H SW P
Sbjct: 2030 SFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSS 2089
Query: 2052 SYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADA 2111
+ R P SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADA
Sbjct: 2090 AARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADA 2149
Query: 2112 CDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DE 2168
CD+TI+EMESAA +L+G NG + P + +D QD G D R E
Sbjct: 2150 CDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSE 2208
Query: 2169 EDLADEMICITTL 2181
E+L D + +++L
Sbjct: 2209 EELQDSRVYVSSL 2221
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 2733 bits (7084), Expect = 0.0
Identities = 1457/2196 (66%), Positives = 1668/2196 (75%), Gaps = 153/2196 (6%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMR 1335
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1336 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1395
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1396 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1455
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1515
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1516 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1575
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1576 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1635
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1636 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1694
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1695 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1753
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1754 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1802
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1803 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1860
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1861 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1891
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1892 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1942
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1943 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 2002
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 2003 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2062
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2063 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2122
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2123 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2157
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 2731 bits (7078), Expect = 0.0
Identities = 1461/2214 (65%), Positives = 1672/2214 (75%), Gaps = 167/2214 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESEN-------------VPVPTATP-----GNS 1327
DAWNTFD+LIV+GSI+D+A++E +P E + V TA P N+
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNA 1339
Query: 1328 EESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVI 1387
EE++RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVI
Sbjct: 1340 EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1399
Query: 1388 GMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDY 1447
GMQ+FGK+A+ D +INRNNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+
Sbjct: 1400 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEP 1459
Query: 1448 NPGE--EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF 1505
+ E CGS+FA+ YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF
Sbjct: 1460 SNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF 1519
Query: 1506 KRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVM 1565
KRIW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVM
Sbjct: 1520 KRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVM 1579
Query: 1566 FNATLFALVRTALKIKTE-------------------GNLEQANEELRAVIKKIWKKTSM 1606
FNATLFALVRTAL+IKTE GNLEQANEELRA+IKKIWK+TSM
Sbjct: 1580 FNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSM 1639
Query: 1607 KLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRT 1666
KLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRT
Sbjct: 1640 KLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRT 1698
Query: 1667 LHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDS 1720
LHDIGPEIRRAIS DL +E E EDD+F+R G L GNHV++ SD R +
Sbjct: 1699 LHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSA 1758
Query: 1721 LQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNN 1780
QT TT RPLH+ + DTE P +S +++S T +NAN+NN
Sbjct: 1759 FPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINN 1810
Query: 1781 ANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQL 1840
AN + RP+ + S H P R V+ + + R S + Q
Sbjct: 1811 ANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQA 1864
Query: 1841 PTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGR 1894
+E+ + D E S+E Y+DD
Sbjct: 1865 AMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD------------------- 1905
Query: 1895 NIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQ 1954
+ Q L ++D D R+SP+R L + + RR+SF+ ECL+RQ +
Sbjct: 1906 ----------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR 1951
Query: 1955 EEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWT 2014
+T LPLHL+ Q +AVAGL + +SP+ R +ATPPATP R W
Sbjct: 1952 -----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWP 2006
Query: 2015 PCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNK 2070
P P +++E E+ +++N S PS+H SW P + R P SL VPS
Sbjct: 2007 PQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAP 2066
Query: 2071 NSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGN 2130
SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G
Sbjct: 2067 GRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGG 2126
Query: 2131 VRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
NG + P + +D QD G D R EE+L D + +++L
Sbjct: 2127 APQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2179
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 2727 bits (7070), Expect = 0.0
Identities = 1455/2196 (66%), Positives = 1667/2196 (75%), Gaps = 164/2196 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN ILG DY FT+IFT+EI+LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVN---------------NAEENSRISITFFRLFRVMR 1324
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1325 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1384
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1385 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1444
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1445 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1504
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1505 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1564
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1565 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1624
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1625 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1683
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1684 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1742
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1743 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1791
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1792 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1849
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1850 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1880
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1881 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1931
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1932 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 1991
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 1992 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2051
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2052 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2111
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2112 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2146
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 2727 bits (7068), Expect = 0.0
Identities = 1455/2196 (66%), Positives = 1665/2196 (75%), Gaps = 164/2196 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E + N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITEVN---------------NAEENSRISITFFRLFRVMR 1324
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1325 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1384
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1385 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1444
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1445 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1504
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1505 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1564
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1565 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1624
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1625 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1683
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1684 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1742
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1743 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1791
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1792 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1849
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1850 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1880
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1881 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1931
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1932 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 1991
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 1992 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2051
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2052 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2111
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2112 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2146
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 2726 bits (7067), Expect = 0.0
Identities = 1460/2225 (65%), Positives = 1673/2225 (75%), Gaps = 182/2225 (8%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFD--------------------YAFTAIFTVEILLKMTTFGAFL 965
EDP++ SFRN IL YFD Y FT+IFT+EI+LKMT +GAFL
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFL 979
Query: 966 HKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVV 1025
HKG+FCRNYFN+LD+LVV VSL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVV
Sbjct: 980 HKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVV 1039
Query: 1026 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDG 1085
QCVFVAIRTIGNI+IVTTLLQFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG
Sbjct: 1040 QCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG 1099
Query: 1086 DVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHR 1145
+VD P+++ R W+NS F+FDNVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+R
Sbjct: 1100 EVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYR 1159
Query: 1146 VEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPL 1205
VEISIFFIIYIII+AFFMMNIFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPL
Sbjct: 1160 VEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219
Query: 1206 RRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1265
RRYIPKN +QYK WYVVNS+ FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FT
Sbjct: 1220 RRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1279
Query: 1266 GVFTVEMVLKVIAFKPKGYFS----------------------------DAWNTFDSLIV 1297
G+FTVEM+LK+IAFKPKGYFS DAWNTFD+LIV
Sbjct: 1280 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIV 1339
Query: 1298 IGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIR 1357
+GSI+D+A++E +P E + N+EE++RISITFFRLFRVMRLVKLLSRGEGIR
Sbjct: 1340 VGSIVDIAITEVNPAEH----TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1395
Query: 1358 TLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVL 1417
TLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INRNNNFQTFPQAVL
Sbjct: 1396 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1455
Query: 1418 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVYFISFYMLCAFLI 1475
LLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ YFISFYMLCAFLI
Sbjct: 1456 LLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLI 1515
Query: 1476 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1535
INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHLDVVTLLRRIQPP
Sbjct: 1516 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPP 1575
Query: 1536 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA 1595
LGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTEGNLEQANEELRA
Sbjct: 1576 LGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRA 1635
Query: 1596 VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN 1655
+IKKIWK+TSMKLLDQVVPPAGDDEVTVGKFYATFLIQ+YFRKFKKRKEQGLVGK P++
Sbjct: 1636 IIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-PSQR 1694
Query: 1656 TTIALQAGLRTLHDIGPEIRRAISCDLQDDE------PEETKREEEDDVFKRNGALLGNH 1709
++LQAGLRTLHDIGPEIRRAIS DL +E E EDD+F+R G L GNH
Sbjct: 1695 NALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNH 1754
Query: 1710 VNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQ 1769
V++ SD R + QT TT RPLH+ + DTE P +S +++S
Sbjct: 1755 VSYYQSDGRSAFPQTFTTQRPLHINKAG-SSQGDTESPSHEKLVDST-FTPSSYSS---- 1808
Query: 1770 VPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYET 1829
T +NAN+NNAN + RP+ + S H P R V+ + +
Sbjct: 1809 --TGSNANINNANNTALGRLPRPA----GYPSTVSTVEGHGPPLSPAIR--VQEVAWKLS 1860
Query: 1830 YIRSDSGDEQLPTICREDPEIHGYF-----RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQ 1883
R S + Q +E+ + D E S+E Y+DD
Sbjct: 1861 SNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDD-------- 1912
Query: 1884 NYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSF 1943
+ Q L ++D D R+SP+R L + + RR+SF
Sbjct: 1913 ---------------------ENRQLTLPEEDK---RDIRQSPKRGFL-RSASLGRRASF 1947
Query: 1944 NFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWAT 2003
+ ECL+RQ + +T LPLHL+ Q +AVAGL + +SP+ R +AT
Sbjct: 1948 HLECLKRQKDR-----GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFAT 2002
Query: 2004 PPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPA 2059
PPATP R W P P +++E E+ +++N S PS+H SW P + R P
Sbjct: 2003 PPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPV 2062
Query: 2060 SLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEM 2119
SL VPS SA SLVEAVLISEGLG++A+DPKF+ T E+ADACD+TI+EM
Sbjct: 2063 SLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM 2122
Query: 2120 ESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMI 2176
ESAA +L+G NG + P + +D QD G D R EE+L D +
Sbjct: 2123 ESAADNILSGGAPQSPNGALLPFVNCRDAG-QDRAGGEEDAGCVRARGRPSEEELQDSRV 2181
Query: 2177 CITTL 2181
+++L
Sbjct: 2182 YVSSL 2186
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 2726 bits (7065), Expect = 0.0
Identities = 1455/2196 (66%), Positives = 1664/2196 (75%), Gaps = 166/2196 (7%)
Query: 51 LSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLS 110
LSWQAAIDAARQAK + + V S +QRKRQQY K KKQG+++ +RP RAL CL+
Sbjct: 50 LSWQAAIDAARQAKLMGSAGNATISTVSS-TQRKRQQYGKPKKQGSTTATRPPRALLCLT 108
Query: 111 LNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI 170
L NPIRRACISIVEWKPF+I ILL IFANCVALAIYIPFPEDDSN+TN NLE+VEY FLI
Sbjct: 109 LKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI 168
Query: 171 IFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGK 230
IFTVE FLK+IAYGLL HPNAY+RNGWNLLDF+IV+VGLFS ILEQ TK +G N GK
Sbjct: 169 IFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK-ADGANALGGK 227
Query: 231 SGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 290
GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL
Sbjct: 228 GAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 291 ELFIGKMHKTCFFAD--SDIVAEEDPAPCAF-SGNGRQCTANGTECRSGWVGPNGGITNF 347
ELF+GKMHKTC+ + +D+ AE+DP+PCA +G+GRQC NGT C+ GW GP GITNF
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNF 346
Query: 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
DNFAFAMLTVFQCITMEGWTDVLYWVNDA+G +WPW+YFV+LII+GSFFVLNLVLGVLSG
Sbjct: 347 DNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406
Query: 408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGK-RNTSM 466
EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENE+EG +E K RN SM
Sbjct: 407 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 467 PTSETESVNTENVSG---EGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSR 523
PTSETESVNTENV+G EGEN CG+ R ISKSK SR
Sbjct: 467 PTSETESVNTENVAGGDIEGEN---CGA-------------------RLAHRISKSKFSR 504
Query: 524 RWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLL 583
WRRWNRF RR+CRAAVKS FYWLVI LVFLNTLTI+SEHYNQP+WLT++QD ANK LL
Sbjct: 505 YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALL 564
Query: 584 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRL 643
ALFT EML+KMYSLGLQAYFVSLFNRFDCFVVCGGI ETILVE +IMSPLGISV RCVRL
Sbjct: 565 ALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL 624
Query: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 703
LRIFK+TR+W SLSNLVASLLNS++SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE QT
Sbjct: 625 LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQT 684
Query: 704 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 763
+RSTFDNFPQ+LLTVFQILTGEDWN+VMYDGIMAYGGPS GM+VCIYFIILFICGNYIL
Sbjct: 685 RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL 744
Query: 764 LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKN--NKPEVNQIANSD- 820
LNVFLAIAVDNLADAESL +AQKEE EEKERKK+AR S E K+ KP V +
Sbjct: 745 LNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI 804
Query: 821 --------------NKVTIDDYR-EEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRP 865
K+ +DD + E+EDK PYP E EE+E+EPE+P GPRP
Sbjct: 805 ELKSITADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEEEPEMPVGPRP 859
Query: 866 RRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAA 925
R +SEL++KEK P+PE SAFFI S N R+ CH+++N IFTNLIL FI+LSS +LAA
Sbjct: 860 RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA 919
Query: 926 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGV 985
EDP++ SFRN IL YFD FT IFT+EI LKMT +GAFLHKG+FCRNYFN+LD+LVV V
Sbjct: 920 EDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSV 979
Query: 986 SLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLL 1045
SL+SFGIQSSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI+IVTTLL
Sbjct: 980 SLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1039
Query: 1046 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFD 1105
QFMFACIGVQLFKGK Y C+D +K EC+G +I YKDG+VD P+++ R W+NS F+FD
Sbjct: 1040 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1099
Query: 1106 NVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMN 1165
NVL+AMMALFTVSTFEGWP LLY++IDS+ E+ GPIYN+RVEISIFFIIYIII+AFFMMN
Sbjct: 1100 NVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMN 1159
Query: 1166 IFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSS 1225
IFVGFVIVTFQEQGE+EYKNCELDKNQRQCVEYALKARPLRRYIPKN +QYK WYVVNS+
Sbjct: 1160 IFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNST 1219
Query: 1226 PFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285
FEY+MFVLI+LNT+CLAMQHY QS +F AM+ILNM+FTG+FTVEM+LK+IAFKPK YF
Sbjct: 1220 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1279
Query: 1286 SDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMR 1345
DAWNTFD+LIV+GSI+D+A++E N+EE++RISITFFRLFRVMR
Sbjct: 1280 CDAWNTFDALIVVGSIVDIAITE-----------------NAEENSRISITFFRLFRVMR 1322
Query: 1346 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR 1405
LVKLLSRGEGIRTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGK+A+ D +INR
Sbjct: 1323 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1382
Query: 1406 NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE--EYTCGSNFAIVY 1463
NNNFQTFPQAVLLLFRCATGEAWQ+IMLAC+PGK C PES+ + E CGS+FA+ Y
Sbjct: 1383 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFY 1442
Query: 1464 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHL 1523
FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW+EYDPEAKGRIKHL
Sbjct: 1443 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHL 1502
Query: 1524 DVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE 1583
DVVTLLRRIQPPLGFGKLCPHRVACKRLV+MNMPLNSDGTVMFNATLFALVRTAL+IKTE
Sbjct: 1503 DVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE 1562
Query: 1584 -------------------GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1624
GNLEQANEELRA+IKKIWK+TSMKLLDQVVPPAGDDEVTVG
Sbjct: 1563 EGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVG 1622
Query: 1625 KFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQD 1684
KFYATFLIQ+YFRKFKKRKEQGLVGK P++ ++LQAGLRTLHDIGPEIRRAIS DL
Sbjct: 1623 KFYATFLIQEYFRKFKKRKEQGLVGK-PSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1681
Query: 1685 DE------PEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSI 1738
+E E EDD+F+R G L GNHV++ SD R + QT TT RPLH+ +
Sbjct: 1682 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG- 1740
Query: 1739 PPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLE 1798
DTE P +S +++S T +NAN+NNAN + RP+
Sbjct: 1741 SSQGDTESPSHEKLVDST-FTPSSYSS------TGSNANINNANNTALGRLPRPA----G 1789
Query: 1799 HVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYF---- 1854
+ S H P R V+ + + R S + Q +E+ +
Sbjct: 1790 YPSTVSTVEGHGPPLSPAIR--VQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM 1847
Query: 1855 -RDPHCLGEQEYFSSEE-CYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLE 1912
D E S+E Y+DD + Q L
Sbjct: 1848 NHDTEACSEPSLLSTEMLSYQDD-----------------------------ENRQLTLP 1878
Query: 1913 DDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLH 1972
++D D R+SP+R L + + RR+SF+ ECL+RQ + +T LPLH
Sbjct: 1879 EEDK---RDIRQSPKRGFL-RSASLGRRASFHLECLKRQKDR-----GGDISQKTVLPLH 1929
Query: 1973 LMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQV 2032
L+ Q +AVAGL + +SP+ R +ATPPATP R W P P +++E E+ +++
Sbjct: 1930 LVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKL 1989
Query: 2033 NGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLIS 2088
N S PS+H SW P + R P SL VPS SA SLVEAVLIS
Sbjct: 1990 NSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS 2049
Query: 2089 EGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDY 2148
EGLG++A+DPKF+ T E+ADACD+TI+EMESAA +L+G NG + P + +D
Sbjct: 2050 EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDA 2109
Query: 2149 ELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2181
QD G D R EE+L D + +++L
Sbjct: 2110 G-QDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL 2144
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 2379 bits (6165), Expect = 0.0
Identities = 1198/1653 (72%), Positives = 1357/1653 (82%), Gaps = 85/1653 (5%)
Query: 83 RKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVA 142
++R Q++K K +S R RALFCL+L NP+RR+CISIVEWKPFDI ILL IFANCVA
Sbjct: 49 KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108
Query: 143 LAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDF 202
L +YIPFPEDDSN+ NHNLE+VEY FL+IFTVET LKI+AYGL+LHP+AY+RNGWNLLDF
Sbjct: 109 LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168
Query: 203 VIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLN 262
+IV+VGLFSV+LEQ H+ GK GGFDVKALRAFRVLRPLRLVSGVPSL +VLN
Sbjct: 169 IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228
Query: 263 SIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGN 322
SI+KA+VPLLHIALLVLFVIIIYAIIGLELF+G+MHKTC+F SD+ AEEDP+PCA SG+
Sbjct: 229 SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288
Query: 323 GRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWP 382
GR CT N TECR W GPNGGITNFDNF FAMLTVFQC+TMEGWTDVLYW+ DA+G+E P
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 WVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWI 442
WVYFVSL+I GSFFVLNLVLGVLSGEFSKEREKAKARGDFQK REKQQ+EEDL+GYLDWI
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWI 408
Query: 443 TQAEDIDPENEE---------EGGEEGKR-----------------------------NT 464
TQAE++D E+ E G G R +
Sbjct: 409 TQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHA 468
Query: 465 SMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRR 524
S+P S+T S+ TE E E G S C R I K+++ RR
Sbjct: 469 SLPASDTGSM-TETQGDEDEEEGALAS-----------------CTRCLNKIMKTRVCRR 510
Query: 525 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLA 584
RR NR R RCR AVKS YW V++LVFLNTLTI+SEH+ QP WLTQIQ+ ANKVLL
Sbjct: 511 LRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLC 570
Query: 585 LFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLL 644
LFT EML+K+Y LG AY S FNRFDCFVVCGGI ET LVE+ M PLGISV RCVRLL
Sbjct: 571 LFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLL 630
Query: 645 RIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK 704
RIFKVTRHW SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD+T TK
Sbjct: 631 RIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK 690
Query: 705 RSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILL 764
RSTFD FPQALLTVFQILTGEDWN VMYDGIMAYGGP GM+VCIYFIILFICGNYILL
Sbjct: 691 RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILL 750
Query: 765 NVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVT 824
NVFLAIAVDNLA ++ TA+ + E+ K + + +N+
Sbjct: 751 NVFLAIAVDNLASGDA-GTAKDKGGEKSNEKDLPQ--------------------ENEGL 789
Query: 825 IDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGS 884
+ +E+E+ D+ EEEEEEEE+E E + E+ KEK+ PIPEGS
Sbjct: 790 VPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGS 849
Query: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDY 944
AFF LS+TNP+R GCH LI+HH+FTNLILVFI+LSS +LAAEDPIR+HSFRN ILGYFDY
Sbjct: 850 AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDY 909
Query: 945 AFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILR 1004
AFT+IFTVEILLKMT FGAFLH+G+FCR++FN+LD+LVV VSL+SFGI SSAISVVKILR
Sbjct: 910 AFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILR 969
Query: 1005 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRC 1064
VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY C
Sbjct: 970 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTC 1029
Query: 1065 TDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWP 1124
TDEAK P+EC+G F++Y DGDV P+VRER+W NSDFNFDNVLSAMMALFTVSTFEGWP
Sbjct: 1030 TDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWP 1089
Query: 1125 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYK 1184
ALLYKAID+ E+ GPIYN+RVEIS+FFI+YIII+AFFMMNIFVGFVI+TF+ QGE+EY+
Sbjct: 1090 ALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQ 1149
Query: 1185 NCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAM 1244
NCELDKNQRQCVEYALKA+PLRRYIPKNP+QY+ W VNS+ FEY+MF+LI+LNT+ LAM
Sbjct: 1150 NCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1209
Query: 1245 QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1304
QHYEQ+ FN AMDILNMVFTG+FT+EMVLK+IAFKPK YF+DAWNTFD+LIV+GSI+D+
Sbjct: 1210 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1269
Query: 1305 ALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFI 1364
A++E + +SE+S+RISITFFRLFRVMRLVKLLS+GEGIRTLLWTFI
Sbjct: 1270 AVTEVNNGGH--------LGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFI 1321
Query: 1365 KSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCAT 1424
KSFQALPYVALLIAM+FFIYAVIGMQMFGKVA++D QINRNNNFQTFPQAVLLLFRCAT
Sbjct: 1322 KSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCAT 1381
Query: 1425 GEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIM 1484
GEAWQEIMLA LPG CDPESD+ PGEE+TCGSNFAI YFISF+MLCAFLIINLFVAVIM
Sbjct: 1382 GEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIM 1441
Query: 1485 DNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPH 1544
DNFDYLTRDWSILGPHHLDEFKRIWSEYDP AKGRIKHLDVV LLRRIQPPLGFGKLCPH
Sbjct: 1442 DNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPH 1501
Query: 1545 RVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKT 1604
RVACKRLVAMNMPLNSDGTV FNATLFALVRT+LKIKTEGNLEQAN+ELR VIKKIWK+
Sbjct: 1502 RVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRM 1561
Query: 1605 SMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGL 1664
KLLD+V+PP ++EVTVGKFYATFLIQDYFRKF++RKE+GL+G A +T+ ALQAGL
Sbjct: 1562 KQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGL 1621
Query: 1665 RTLHDIGPEIRRAISCDLQDDEPEETKREEEDD 1697
R+L D+GPE+R+A++CD +++E E + EE+D
Sbjct: 1622 RSLQDLGPEMRQALTCDTEEEEEEGQEGVEEED 1654
Score = 135 bits (340), Expect = 4e-31
Identities = 105/262 (40%), Positives = 128/262 (48%), Gaps = 67/262 (25%)
Query: 1921 DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMA 1980
D PRRRLLPPTPA R+ SF +CL+RQ S E++P + HR
Sbjct: 1782 DGHLVPRRRLLPPTPAG-RKPSFTIQCLQRQGSCEDLPIPGTY-HR-------------- 1825
Query: 1981 VAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLH 2040
+ P+ + SWATPP Y PL+ VE+ A + G
Sbjct: 1826 --------GRNSGPNRAQGSWATPPQRGRL-----LYAPLLLVEEGAAGEGYLG------ 1866
Query: 2041 RSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKF 2100
RSS RTFT L VP + + + K+ SADSLVEAVLISEGLG +ARDP+F
Sbjct: 1867 RSSG-------PLRTFT--CLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRF 1917
Query: 2101 VSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDE 2160
V+ K EIADAC LT+DEM++AAS LL Q YSDE
Sbjct: 1918 VALAKQEIADACRLTLDEMDNAASDLL----------------------AQGTSSLYSDE 1955
Query: 2161 EPDPGR-DEEDLADEMICITTL 2181
E R DEEDL DEM C+ L
Sbjct: 1956 ESILSRFDEEDLGDEMACVHAL 1977
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 2269 bits (5879), Expect = 0.0
Identities = 1172/1784 (65%), Positives = 1377/1784 (77%), Gaps = 111/1784 (6%)
Query: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
Query: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
Query: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
Query: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
Query: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
Query: 366 WTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
WTDVLYWVNDAIG EWPW+YFV+LI+LGSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
Query: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+
Sbjct: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLYEI-------- 401
Query: 486 RGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTF 545
+G + Q I R WR+WNR R +C VKS F
Sbjct: 402 ---------------------AGLNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVF 434
Query: 546 YWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVS 605
YWLVI++V LNTL+I+SEH+NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S
Sbjct: 435 YWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMS 494
Query: 606 LFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 665
+FNRFDCFVVC GI E +LVE M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLN
Sbjct: 495 IFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLN 554
Query: 666 SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 725
S++SIASLLLLLFLFI+IF+LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGE
Sbjct: 555 SIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGE 614
Query: 726 DWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 785
DW ++MY+GIMAYGGPS GM+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQ
Sbjct: 615 DWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQ 674
Query: 786 KEEAEEKERKKIAR---------KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDK 835
K +AEEK+R+K+++ K ++ K KP+ I + K+ ID++ +E K
Sbjct: 675 KAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVK 733
Query: 836 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPI 895
DPYP D P ++EEDEPE+P PRPR ++EL +KEK PIPE S+FFI S TN I
Sbjct: 734 DPYPSADFP-----GDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKI 788
Query: 896 RVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEIL 955
RV CH+++N FTN IL+FI+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+
Sbjct: 789 RVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIV 848
Query: 956 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1015
LKMTT+GAFLHKG+FCRNYFN+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAI
Sbjct: 849 LKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAI 908
Query: 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1075
NRAKGLKHVVQC+FVAI TIGNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EEC
Sbjct: 909 NRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEEC 968
Query: 1076 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1135
RG + +YKDGD +R R W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN
Sbjct: 969 RGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNA 1028
Query: 1136 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1195
E++GPIYN+RVE++IFFIIYII++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQC
Sbjct: 1029 EDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQC 1088
Query: 1196 VEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFND 1255
V+YALKARPLR YIPKNPYQY+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N
Sbjct: 1089 VQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNH 1148
Query: 1256 AMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESE 1315
DILN+ FT +FT+EM+LK++AFK +GYF D WN FD LIVIGSIIDV LSE D +
Sbjct: 1149 ISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLAS 1208
Query: 1316 NVPVPTATPG----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 1371
+ + G + +ES RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALP
Sbjct: 1209 SGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALP 1268
Query: 1372 YVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEI 1431
YVALLI MLFFIYAVIGMQMFGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI
Sbjct: 1269 YVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEI 1328
Query: 1432 MLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLT 1491
+LAC GKLCDPESDY PGEEYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLT
Sbjct: 1329 LLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLT 1388
Query: 1492 RDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRL 1551
RDWSILGPHHLDEFK IW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRL
Sbjct: 1389 RDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRL 1448
Query: 1552 VAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQ 1611
V MNMPLNSDGTV FNATLFALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQ
Sbjct: 1449 VGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQ 1508
Query: 1612 VVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDI 1670
V+PP GDDEVTVGKFYATFLIQ++FRKF KR+E+ Y K + +QAGLRT+ +
Sbjct: 1509 VIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEA 1566
Query: 1671 GPEIRRAISCDLQDDEPEETKREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTT 1727
PEI R +S DL +E E E E+ +F+R G L G N + +R +SL
Sbjct: 1567 APEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMAN 1624
Query: 1728 HRPLHVQRPSIPPASDTEKPLF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1781
RPL + + E P+F P N + AN NNA
Sbjct: 1625 QRPLQFAEIEM---EEMESPVFLEDFPQDPRTNPL-----------------ARANTNNA 1664
Query: 1782 NMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTR 1825
N + A GN H + + S H ++RE + TR
Sbjct: 1665 NANVA-------YGNSNHSNSHVFSSVH-YEREFPEETETPATR 1700
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 2054 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2108
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
Query: 2109 ADACDLTIDEMESAASTLLNGNVRP 2133
ADAC + +E+E A+ LL G P
Sbjct: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 773 bits (1997), Expect = 0.0
Identities = 399/825 (48%), Positives = 552/825 (66%), Gaps = 56/825 (6%)
Query: 840 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 899
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1192 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1237
Query: 900 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 959
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1238 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1297
Query: 960 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 1015
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1298 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1357
Query: 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1075
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1358 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1417
Query: 1076 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1135
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1418 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
Query: 1136 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1195
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1475 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1534
Query: 1196 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1253
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1535 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1594
Query: 1254 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1313
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1595 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1650
Query: 1314 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1373
GN N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1651 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1695
Query: 1374 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1425
LLIAMLFFIYA+IGMQ+FG + + D QI +NNF+TF QA++LLFR ATG
Sbjct: 1696 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1755
Query: 1426 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1485
EAW IML+CL GK CD S E CG+ FA YF+SF LC+FL++NLFVAVIMD
Sbjct: 1756 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1812
Query: 1486 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1545
NF+YLTRD SILGPHHLDE+ R+W+EYDP A GRI + D+ +LLR I PPLG GK CPHR
Sbjct: 1813 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHR 1872
Query: 1546 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1602
VACKRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + ELR + IW
Sbjct: 1873 VACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1932
Query: 1603 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1647
S K LD +V P ++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1933 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1977
Score = 655 bits (1689), Expect = 0.0
Identities = 357/740 (48%), Positives = 474/740 (64%), Gaps = 51/740 (6%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ LII+GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 --GKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAIS 517
R T++ S+T+ +N E + + GS + R + K+ +
Sbjct: 418 DGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFA----RASIKSAK---------LE 464
Query: 518 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDI 577
S + R RF RR VK+ FYW V+ LV LNTL ++ HYNQP+WL+
Sbjct: 465 NSTFFHKKERRMRFYIRRM---VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYY 521
Query: 578 ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISV 637
A + L LF EM +KMY LG + YF S FN FDC V+ G I E I ++ + GISV
Sbjct: 522 AEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISV 581
Query: 638 FRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN 697
R +RLLRIFKVT++W SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FN
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN 641
Query: 698 FDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFI 757
FDE T + FD FP A++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L +
Sbjct: 642 FDE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTL 699
Query: 758 CGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIA 817
GNY LLNVFLAIAVDNLA+A+ L T ++E EE +K+A +++ E EV+ ++
Sbjct: 700 FGNYTLLNVFLAIAVDNLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLS 753
Query: 818 NSDNKVTIDDYREEDEDKDP 837
++ + + +E+ +++ P
Sbjct: 754 AANMSIAV---KEQQKNQKP 770
Score = 188 bits (477), Expect = 6e-47
Identities = 169/706 (23%), Positives = 297/706 (42%), Gaps = 153/706 (21%)
Query: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS-LVSFGIQSSAISVVK 1001
+ F IF E +K+ G HKG++ RN +N++D +VV L + G + ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 1002 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1061
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 1062 YR-CTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFNF 1104
+ C +E + + G+ +P E W+ N F
Sbjct: 253 HTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
Query: 1105 DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMM 1164
DN+L A++ +F T EGW LLY + D++G +Y FI III +FFM+
Sbjct: 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFML 352
Query: 1165 NIFVG------------------FVIVTFQEQGEKEYKNC---------------ELDKN 1191
N+ +G F+ + Q+Q E+E E D
Sbjct: 353 NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412
Query: 1192 QRQCVEYALKARPLRR---------------------------------------YIPKN 1212
QR + AL+ +++ + K
Sbjct: 413 QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472
Query: 1213 PYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTV 1270
+ +F+ +V + F + + L+ LNTLC+A+ HY Q + +D + +F G+F
Sbjct: 473 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532
Query: 1271 EMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEES 1330
EM +K+ + YF ++N FD ++IGSI +V + P S
Sbjct: 533 EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS---------------- 576
Query: 1331 NRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQ 1390
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ
Sbjct: 577 --FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
Query: 1391 MFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPG 1450
+FG D NF TFP A++ +F+ TGE W E+M D
Sbjct: 635 LFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------------DGIKS 680
Query: 1451 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493
+ G +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 681 QGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 726
Score = 137 bits (346), Expect = 9e-32
Identities = 105/403 (26%), Positives = 194/403 (48%), Gaps = 49/403 (12%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1185 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1244
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1245 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1302
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1303 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1349
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1350 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1404
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1405 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1459
Query: 364 EGWTDVLYWVNDAI--------GWEWPW-VYFVSLIILGSFFVLNLVLGVLSGEFSKERE 414
EGW VL DA G+ +++V ++ FF +N+ + ++ F ++
Sbjct: 1460 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-- 1517
Query: 415 KAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID---PENEE 454
GD K+ E+ LE++ + +D+ A+ + P+N++
Sbjct: 1518 -----GD--KMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQ 1553
Score = 137 bits (345), Expect = 1e-31
Identities = 181/801 (22%), Positives = 327/801 (40%), Gaps = 177/801 (22%)
Query: 479 VSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFN----RR 534
V G G RG GS R+G G G +R + K +++R R +N R+
Sbjct: 24 VVGSGGGRGAGGS------RQG----GQPGAQR----MYKQSMAQRARTMALYNPIPVRQ 69
Query: 535 RC----------------RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
C R K +T F ++++ + N + ++ E + D T +
Sbjct: 70 NCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129
Query: 575 Q---DIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVEL 627
D + +F E +K+ +LG +Y + +N D VV GI T+ E
Sbjct: 130 SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF 189
Query: 628 EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 687
++ + R VR+LR K+ SL ++ S++ +M + + LLLF I+IF+++
Sbjct: 190 DLRT------LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAII 243
Query: 688 GMQLFGGKFN---FDE--------------TQTKRST--------------------FDN 710
G++ + GKF+ F+E T+ T FDN
Sbjct: 244 GLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDN 303
Query: 711 FPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAI 770
A+LTVFQ +T E W ++Y+ A G + +YFI L I G++ +LN+ L +
Sbjct: 304 ILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGV 358
Query: 771 AVDNLADAESLNTAQKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYR 829
A ++E E + K+ R++ +E + N E I+ ++ + +D
Sbjct: 359 LSGEFAK-------ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-E 408
Query: 830 EEDEDKDPYPPC-----------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIA 878
+ E + P+ D+ EE E++ D V + I +
Sbjct: 409 TDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL----- 463
Query: 879 PIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTI 938
E S FF K +R +++ F +L + L++ +A + +
Sbjct: 464 ---ENSTFFH-KKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDF 518
Query: 939 LGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSA 996
L Y ++ F +F E+ +KM G + + FN D V+ S+ V + +
Sbjct: 519 LYYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPG 574
Query: 997 ISV-VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQ 1055
S + +LR LR+LR + L+++V + ++++I +++ + L +FA +G+Q
Sbjct: 575 TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 634
Query: 1056 LFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALF 1115
LF G+F + D +P NFD +A+M +F
Sbjct: 635 LFGGQF----------------------NFDEGTPPT----------NFDTFPAAIMTVF 662
Query: 1116 TVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI--- 1172
+ T E W ++Y I S G G + SI+FI+ + + ++N+F+ +
Sbjct: 663 QILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNL 717
Query: 1173 -----VTFQEQGEKEYKNCEL 1188
+T EQ E+E N +L
Sbjct: 718 ANAQELTKDEQEEEEAANQKL 738
Score = 106 bits (264), Expect = 3e-22
Identities = 74/278 (26%), Positives = 141/278 (50%), Gaps = 20/278 (7%)
Query: 515 AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
AIS L+R + + + R V S F + ++ ++ LNT+ + + Y
Sbjct: 1538 AISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA 1597
Query: 575 QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634
+ N V +LF+ E ++K+ + G+ YF +N FD V G IT+ ++ E + +
Sbjct: 1598 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFIN 1656
Query: 635 ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 694
+S R R R+ K+ R ++ L+ + + S K++ + LL+ + I++++GMQ+FG
Sbjct: 1657 LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1716
Query: 695 --------KFNFDETQ-TKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 745
+ DE Q T+ + F F QAL+ +F+ TGE W+ +M + +SG
Sbjct: 1717 IGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSG 1776
Query: 746 MI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 774
++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1777 ILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 91.3 bits (225), Expect = 9e-18
Identities = 70/278 (25%), Positives = 128/278 (46%), Gaps = 38/278 (13%)
Query: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEML 591
RR C + F +++++ ++++ +++E QP+ + + V +FT EM+
Sbjct: 1234 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1293
Query: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRI 646
+KM LGL AYF L+N D VV G + + I R +R+LR
Sbjct: 1294 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1353
Query: 647 FKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRS 706
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF ++K
Sbjct: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413
Query: 707 T----------------------------FDNFPQALLTVFQILTGEDWNAVM---YDGI 735
+DN ALLT+F + TGE W V+ D
Sbjct: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473
Query: 736 MAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAV 772
GPS M + I++++ F+ + +N+F+A+ +
Sbjct: 1474 FENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1511
Score = 82.8 bits (203), Expect = 3e-15
Identities = 78/296 (26%), Positives = 134/296 (45%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1567 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1623
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1624 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1667
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1668 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1726
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1727 D----EDEF---------QITEH---------------NNFRTFFQALMLLFRSATGEAW 1758
Query: 367 TDVLYWV--------NDAI-----GWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
+++ N I G E+ + YFVS I L SF +LNL + V+ F
Sbjct: 1759 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 765 bits (1975), Expect = 0.0
Identities = 395/825 (47%), Positives = 550/825 (66%), Gaps = 56/825 (6%)
Query: 840 PCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGC 899
P +P EEE++EEE++ GP+P +P S+ FILS TNP+R C
Sbjct: 1191 PDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNPLRRLC 1236
Query: 900 HKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMT 959
H ++N F IL+ I +SS ALAAEDP++ ++ RN +L YFDY FT +FT E+++KM
Sbjct: 1237 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1296
Query: 960 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----ISVVKILRVLRVLRPLRAI 1015
G LH+GA+ R+ +N+LD +VV +LV+F ++ I+ +K LRVLRVLRPL+ I
Sbjct: 1297 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTI 1356
Query: 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1075
R LK V CV +++ + NI+IV L F+FA + VQLFKGKF+ CTDE+K ++C
Sbjct: 1357 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDC 1416
Query: 1076 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1135
RG ++LY+ +V + R+R W+ +F++DNVL A++ LFTVST EGWP +L ++D+
Sbjct: 1417 RGKYLLYEKNEVKA---RDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1473
Query: 1136 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1195
EN GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + L+KN+R C
Sbjct: 1474 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1533
Query: 1196 VEYALKARPLRRYIPKNP--YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMF 1253
+++A+ A+PL R++P+N +QY+ W V S PFEY + +I LNT+ L M+ Y S +
Sbjct: 1534 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1593
Query: 1254 NDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTE 1313
+A+ + N+VFT +F++E VLKV+AF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1594 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF---- 1649
Query: 1314 SENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1373
GN N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1650 -----------GN----NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1694
Query: 1374 ALLIAMLFFIYAVIGMQMFGKVAM--------RDNNQINRNNNFQTFPQAVLLLFRCATG 1425
LLIAMLFFIYA+IGMQ+FG + + D QI +NNF+TF QA++LLFR ATG
Sbjct: 1695 CLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATG 1754
Query: 1426 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMD 1485
EAW IML+CL GK CD S E CG+ FA YF+SF LC+FL++NLFVAVIMD
Sbjct: 1755 EAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD 1811
Query: 1486 NFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1545
NF+YLTRD SILGPHHLDE+ R+W+EYDP A GR+ +LD+ +LR + PPLG GK CP R
Sbjct: 1812 NFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPAR 1871
Query: 1546 VACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWK 1602
VA KRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + ELR + IW
Sbjct: 1872 VAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP 1931
Query: 1603 KTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGL 1647
S K LD +V P ++TVGK YA +I +Y+R+ K +K Q +
Sbjct: 1932 NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAM 1976
Score = 655 bits (1690), Expect = 0.0
Identities = 357/739 (48%), Positives = 474/739 (64%), Gaps = 50/739 (6%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+DD + L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G H +Y+RNGWN++DFV+V+ G+ + + +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE------- 188
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAM+PLL I LL+ F I+
Sbjct: 189 ----------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
I+AIIGLE ++GK H TCF +D + E PAPC R C NGT+C+ W GPN G
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCP-NGTKCQPYWEGPNNG 297
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLG 403
IT FDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ LII+GSFF+LNLVLG
Sbjct: 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLG 357
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE---- 459
VLSGEF+KERE+ + R F KLR +QQ+E +L GY++WI++AE++ +E GE+
Sbjct: 358 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPF 417
Query: 460 -GKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISK 518
R T++ S+T+ +N E + + GS + R + K+ +
Sbjct: 418 DALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFA----RASIKSAK---------LEN 464
Query: 519 SKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIA 578
S + R RF RR VK+ FYW V+ LV LNTL ++ HYNQP+WL+ A
Sbjct: 465 STFFHKKERRMRFYIRRM---VKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 521
Query: 579 NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVF 638
+ L LF EM +KMY LG + YF S FN FDC V+ G I E I ++ + GISV
Sbjct: 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVL 581
Query: 639 RCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 698
R +RLLRIFKVT++W SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 582 RALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 641
Query: 699 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758
DE T + FD FP A++TVFQILTGEDWN VMYDGI + GG GM+ IYFI+L +
Sbjct: 642 DE-GTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGG-VQGGMVFSIYFIVLTLF 699
Query: 759 GNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIAN 818
GNY LLNVFLAIAVDNLA+A+ L T ++E EE +K+A +++ E EV+ ++
Sbjct: 700 GNYTLLNVFLAIAVDNLANAQEL-TKDEQEEEEAANQKLALQKAKE-----VAEVSPLSA 753
Query: 819 SDNKVTIDDYREEDEDKDP 837
++ + + +E+ +++ P
Sbjct: 754 ANMSIAV---KEQQKNQKP 769
Score = 137 bits (346), Expect = 9e-32
Identities = 181/800 (22%), Positives = 327/800 (40%), Gaps = 176/800 (22%)
Query: 479 VSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFN----RR 534
V G G RG GS R+G G G +R + K +++R R +N R+
Sbjct: 24 VVGSGGGRGAGGS------RQG----GQPGAQR----MYKQSMAQRARTMALYNPIPVRQ 69
Query: 535 RC----------------RAAVKSVT----FYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
C R K +T F ++++ + N + ++ E + D T +
Sbjct: 70 NCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129
Query: 575 Q---DIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVEL 627
D + +F E +K+ +LG +Y + +N D VV GI T+ E
Sbjct: 130 SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF 189
Query: 628 EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 687
++ + R VR+LR K+ SL ++ S++ +M + + LLLF I+IF+++
Sbjct: 190 DLRT------LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAII 243
Query: 688 GMQLFGGKFN---FDE--------------TQTKRST--------------------FDN 710
G++ + GKF+ F+E T+ T FDN
Sbjct: 244 GLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDN 303
Query: 711 FPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAI 770
A+LTVFQ +T E W ++Y+ A G + +YFI L I G++ +LN+ L +
Sbjct: 304 ILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN-----WLYFIPLIIIGSFFMLNLVLGV 358
Query: 771 AVDNLADAESLNTAQKEEAEEKER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYR 829
A ++E E + K+ R++ +E + N E I+ ++ + +D
Sbjct: 359 LSGEFAK-------ERERVENRRAFLKLRRQQQIERELNGYME--WISKAEEVILAED-E 408
Query: 830 EEDEDKDPYPPC----------DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAP 879
+ E + P+ D+ EE E++ D V + I +
Sbjct: 409 TDGEQRHPFDALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKL------ 462
Query: 880 IPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTIL 939
E S FF K +R +++ F +L + L++ +A + + L
Sbjct: 463 --ENSTFFH-KKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVH-YNQPEWLSDFL 518
Query: 940 GYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAI 997
Y ++ F +F E+ +KM G + + FN D V+ S+ V + +
Sbjct: 519 YYAEFIFLGLFMSEMFIKMYGLGT----RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGT 574
Query: 998 SV-VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQL 1056
S + +LR LR+LR + L+++V + ++++I +++ + L +FA +G+QL
Sbjct: 575 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 634
Query: 1057 FKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFT 1116
F G+F + D +P NFD +A+M +F
Sbjct: 635 FGGQF----------------------NFDEGTPPT----------NFDTFPAAIMTVFQ 662
Query: 1117 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI---- 1172
+ T E W ++Y I S G G + SI+FI+ + + ++N+F+ +
Sbjct: 663 ILTGEDWNEVMYDGIKSQGGVQGGMV-----FSIYFIVLTLFGNYTLLNVFLAIAVDNLA 717
Query: 1173 ----VTFQEQGEKEYKNCEL 1188
+T EQ E+E N +L
Sbjct: 718 NAQELTKDEQEEEEAANQKL 737
Score = 137 bits (346), Expect = 9e-32
Identities = 105/403 (26%), Positives = 194/403 (48%), Gaps = 49/403 (12%)
Query: 67 QTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWK 126
Q + P P+ + K+++ + + P ++F LS NP+RR C I+ +
Sbjct: 1184 QVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLR 1243
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
F++ IL+ I + +ALA P + N+ L +Y F +FT E +K+I GL+
Sbjct: 1244 YFEMCILMVIAMSSIALAAEDPVQPNAPR--NNVLRYFDYVFTGVFTFEMVIKMIDLGLV 1301
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFD---VKALRAFR 243
LH AY R+ WN+LDF++V L + +G S G D +K+LR R
Sbjct: 1302 LHQGAYFRDLWNILDFIVVSGALVAFAF-------------TGNSKGKDINTIKSLRVLR 1348
Query: 244 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFF 303
VLRPL+ + +P L+ V + ++ ++ + +I ++ + + I+A++ ++LF GK FF
Sbjct: 1349 VLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FF 1403
Query: 304 ADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITM 363
+D ++E C G+ E ++ ++DN +A+LT+F T
Sbjct: 1404 HCTD-ESKEFEKDC----RGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTG 1458
Query: 364 EGWTDVLYWVNDAI--------GWEWPW-VYFVSLIILGSFFVLNLVLGVLSGEFSKERE 414
EGW VL DA G+ +++V ++ FF +N+ + ++ F ++
Sbjct: 1459 EGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-- 1516
Query: 415 KAKARGDFQKLREKQQLEEDLKGYLDWITQAEDID---PENEE 454
GD K+ E+ LE++ + +D+ A+ + P+N++
Sbjct: 1517 -----GD--KMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQ 1552
Score = 118 bits (295), Expect = 7e-26
Identities = 78/296 (26%), Positives = 137/296 (46%), Gaps = 44/296 (14%)
Query: 1201 KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL 1260
K R +R YI + +V + F + + L+ LNTLC+A+ HY Q + +D +
Sbjct: 471 KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 521
Query: 1261 NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVP 1320
+F G+F EM +K+ + YF ++N FD ++IGSI +V + P S
Sbjct: 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS------ 575
Query: 1321 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
I+ R R++R+ K+ +R L+ + + S +++ + L+ +
Sbjct: 576 ------------FGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLF 623
Query: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL 1440
++A++GMQ+FG D NF TFP A++ +F+ TGE W E+M
Sbjct: 624 IVVFALLGMQLFGGQFNFDEG--TPPTNFDTFPAAIMTVFQILTGEDWNEVMY------- 674
Query: 1441 CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493
D + G +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 675 -----DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 106 bits (264), Expect = 3e-22
Identities = 74/278 (26%), Positives = 141/278 (50%), Gaps = 20/278 (7%)
Query: 515 AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
AIS L+R + + + R V S F + ++ ++ LNT+ + + Y
Sbjct: 1537 AISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA 1596
Query: 575 QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634
+ N V +LF+ E ++K+ + G+ YF +N FD V G IT+ ++ E + +
Sbjct: 1597 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFIN 1655
Query: 635 ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 694
+S R R R+ K+ R ++ L+ + + S K++ + LL+ + I++++GMQ+FG
Sbjct: 1656 LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1715
Query: 695 --------KFNFDETQ-TKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 745
+ DE Q T+ + F F QAL+ +F+ TGE W+ +M + +SG
Sbjct: 1716 IGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSG 1775
Query: 746 MI--------VCIYFI-ILFICGNYILLNVFLAIAVDN 774
++ YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1776 ILTRECGNEFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1812
Score = 103 bits (257), Expect = 2e-21
Identities = 91/338 (26%), Positives = 158/338 (46%), Gaps = 47/338 (13%)
Query: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942
+ F+ S+ N +R K+ F +IL I+ + LA E P + + L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 1000
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGI-LATVGTEFD----L 191
Query: 1001 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1060
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ +FA IG++ + GK
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 1061 FY-RCTDEAKSNPEECRGLFILYKDGDVDSPVVRER-------------IWQ---NSDFN 1103
F+ C +E + + G+ +P E W+ N
Sbjct: 252 FHTTCFEEGTDDIQ-----------GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ 300
Query: 1104 FDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFM 1163
FDN+L A++ +F T EGW LLY + D++G +Y FI III +FFM
Sbjct: 301 FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY---------FIPLIIIGSFFM 351
Query: 1164 MNIFVGFVIVTFQEQGEK-EYKNCELDKNQRQCVEYAL 1200
+N+ +G + F ++ E+ E + L ++Q +E L
Sbjct: 352 LNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
Score = 91.3 bits (225), Expect = 9e-18
Identities = 70/278 (25%), Positives = 128/278 (46%), Gaps = 38/278 (13%)
Query: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEML 591
RR C + F +++++ ++++ +++E QP+ + + V +FT EM+
Sbjct: 1233 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMV 1292
Query: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLG-ISVFRCVRLLRI 646
+KM LGL AYF L+N D VV G + + I R +R+LR
Sbjct: 1293 IKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRP 1352
Query: 647 FKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRS 706
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF ++K
Sbjct: 1353 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1412
Query: 707 T----------------------------FDNFPQALLTVFQILTGEDWNAVM---YDGI 735
+DN ALLT+F + TGE W V+ D
Sbjct: 1413 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1472
Query: 736 MAYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAV 772
GPS M + I++++ F+ + +N+F+A+ +
Sbjct: 1473 FENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALII 1510
Score = 82.8 bits (203), Expect = 3e-15
Identities = 78/296 (26%), Positives = 134/296 (45%), Gaps = 61/296 (20%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ I+ I N + L + S + + L F +F++E LK++A+G+L
Sbjct: 1566 PFEYTIMAMIALNTIVLMMKF---YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL 1622
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ TE GN+ ++ LR FR R
Sbjct: 1623 ----NYFRDAWNIFDFVTVLGSITDILV------TEFGNNF------INLSFLRLFRAAR 1666
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F G + DS
Sbjct: 1667 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDS 1725
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
D ED Q T + NF F A++ +F+ T E W
Sbjct: 1726 D----EDEF---------QITEH---------------NNFRTFFQALMLLFRSATGEAW 1757
Query: 367 TDVLYWV--------NDAI-----GWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
+++ N I G E+ + YFVS I L SF +LNL + V+ F
Sbjct: 1758 HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
Score = 69.7 bits (169), Expect = 3e-11
Identities = 67/308 (21%), Positives = 120/308 (38%), Gaps = 89/308 (28%)
Query: 1226 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1278
PFEYM+ I+ N + LA++ + + ++ +D F G+F E +K+IA
Sbjct: 99 PFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFA 158
Query: 1279 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1338
F Y + WN D ++V+ I+ +E D +
Sbjct: 159 FHKGSYLRNGWNVMDFVVVLTGILATVGTEFD------------------------LRTL 194
Query: 1339 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAM 1397
R RV+R +KL+S ++ +L + +K+ L + LL+ I+A+IG++ + GK
Sbjct: 195 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHT 254
Query: 1398 R--------------------------------------DNNQINRNNNFQTFPQAVLLL 1419
NN I + F AVL +
Sbjct: 255 TCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ---FDNILFAVLTV 311
Query: 1420 FRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLF 1479
F+C T E W +++ YN + G+ + +YFI ++ +F ++NL
Sbjct: 312 FQCITMEGWTDLL--------------YNSND--ASGNTWNWLYFIPLIIIGSFFMLNLV 355
Query: 1480 VAVIMDNF 1487
+ V+ F
Sbjct: 356 LGVLSGEF 363
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 761 bits (1965), Expect = 0.0
Identities = 466/1171 (39%), Positives = 646/1171 (55%), Gaps = 141/1171 (12%)
Query: 842 DVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHK 901
D+ E ++E E + + +GPRP I P S+ F LS TN +R CH
Sbjct: 1100 DLESQAEGKKEVEADDVMRSGPRP-----------IVPY---SSMFCLSPTNLLRRFCHY 1145
Query: 902 LINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 961
++ F +ILV I LSS ALAAEDP+R+ S RN L Y DY FT +FT E+++KM
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1205
Query: 962 GAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA---ISVVKILRVLRVLRPLRAINRA 1018
G LH GA+ R+ +N+LD +VV +LV+F S I+ +K LRVLRVLRPL+ I R
Sbjct: 1206 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRL 1265
Query: 1019 KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1078
LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTDE+K +CRG
Sbjct: 1266 PKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQ 1325
Query: 1079 FILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENI 1138
++ Y+ +V++ + R W+ DF++DNVL A++ LFTVST EGWP +L ++D+ E
Sbjct: 1326 YLDYEKEEVEA---QPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQ 1382
Query: 1139 GPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY 1198
GP +R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K C L+KN+R C+++
Sbjct: 1383 GPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDF 1442
Query: 1199 ALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDA 1256
A+ A+PL RY+P+N +QYK W V S PFEY + +I LNT+ L M+ Y+ +
Sbjct: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
Query: 1257 MDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESEN 1316
+ LN+VFT +F++E VLK+IAF YF DAWN FD + V+GSI D+ ++E
Sbjct: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI------- 1555
Query: 1317 VPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1376
+E +N I+++F RLFR RL+KLL +G IR LLWTF++SF+ALPYV LL
Sbjct: 1556 ----------AETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1605
Query: 1377 IAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL 1436
IAMLFFIYA+IGMQ+FG +A+ D+ INR+NNF+TF QA++LLFR ATGEAW EIML+CL
Sbjct: 1606 IAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Query: 1437 PGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI 1496
+ CD +++ CGS+FA YF+SF LC+FL++NLFVAVIMDNF+YLTRD SI
Sbjct: 1666 SNQACDEQANAT-----ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1720
Query: 1497 LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNM 1556
LGPHHLDEF R+W+EYDP A GRI + D+ +L+ + PPLG GK CP RVA KRLV MNM
Sbjct: 1721 LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNM 1780
Query: 1557 PL-NSDGTVMFNATLFALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQV 1612
P+ N D TV F +TL AL+RTAL+IK Q + ELR I +W K LD +
Sbjct: 1781 PISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLL 1840
Query: 1613 VPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGP 1672
VPP DE+TVGK YA +I D++++ K ++Q +Q L +GP
Sbjct: 1841 VPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQ--------------MQQAPGGLSQMGP 1886
Query: 1673 -EIRRAISCDLQDDEPEETK------REEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTN 1725
+ + L+ +P + R++ GA+ N + + T
Sbjct: 1887 VSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAI----QNQESGIKESVSWGTQ 1942
Query: 1726 TTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGK--QVPTSTNANLNNANM 1783
T H RP + TE P+ +V + G + + A+M
Sbjct: 1943 RTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASM 2002
Query: 1784 SKAAHGKRP---------SIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIRSD 1834
+ A +P SI L H S DR P ++S ++ + R D
Sbjct: 2003 PRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQAS-SHHHHHRCHRRRD 2061
Query: 1835 SGDEQL---------------------------PTICREDPEIHGYFRDPHCLGEQEYFS 1867
L PT CR + E QE
Sbjct: 2062 RKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERE-----------RRQERGR 2110
Query: 1868 SEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPR-GYH------------HPQGFLEDD 1914
S+E + SS + +Q + R+ GR +P H HPQG +
Sbjct: 2111 SQERRQPSSSSS-EKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVN 2169
Query: 1915 DSPVCYDSRRSP----RRRLLPPTPASHRRS 1941
SP+ S S RR LP TP + R S
Sbjct: 2170 GSPLLSTSGASTPGRGGRRQLPQTPLTPRPS 2200
Score = 628 bits (1620), Expect = e-179
Identities = 352/706 (49%), Positives = 455/706 (64%), Gaps = 43/706 (6%)
Query: 104 RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEK 163
R+LF S +N +R+ I EW PF+ IL I ANC+ LA+ P+ D + L+
Sbjct: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
Query: 164 VEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEG 223
E F+ IF E +KIIA G + H +Y+RNGWN++DFV+V+ G+ + T G
Sbjct: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---------TAG 183
Query: 224 GNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 283
+ FD++ LRA RVLRPL+LVSG+PSLQVVL SI+KAMVPLL I LL+ F I+
Sbjct: 184 TD--------FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
Query: 284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGG 343
++AIIGLE ++GK HK CF +D D PC R C + TECR W GPN G
Sbjct: 236 MFAIIGLEFYMGKFHKACFPNSTDAEPVGD-FPCGKEAPARLCEGD-TECREYWPGPNFG 293
Query: 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLG 403
ITNFDN FA+LTVFQCITMEGWTD+LY NDA G W W+YF+ LII+GSFF+LNLVLG
Sbjct: 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLG 353
Query: 404 VLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRN 463
VLSGEF+KERE+ + R F KLR +QQ+E +L GYL+WI +AE++ E+ EE
Sbjct: 354 VLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPL 413
Query: 464 TSMPTSETESVNTENVSGE-GENRGC----CGSLWCWWRRRGAAKAGPSGCRRWGQAISK 518
+ + T+ + + E GE+R GS + R + K+G K
Sbjct: 414 DVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFA----RASLKSG------------K 457
Query: 519 SKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIA 578
++ S +RR + R R VK+ +FYW+V+ +V LNTL ++ HYNQP LT A
Sbjct: 458 TESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFA 517
Query: 579 NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVF 638
V L LF EM +KMY LG ++YF S FN FD V+ G + E + ++ S GISV
Sbjct: 518 EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL 577
Query: 639 RCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 698
R +RLLRIFKVT++W+SL NLV SLLNSMKSI SLL LLFLFI++F+LLGMQLFGG+FNF
Sbjct: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 637
Query: 699 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758
+ +T + FD FP A+LTVFQILTGEDWNAVMY GI + GG S GM YFI+L +
Sbjct: 638 QD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGG-VSKGMFSSFYFIVLTLF 695
Query: 759 GNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLE 804
GNY LLNVFLAIAVDNLA+A+ L T +EE EE +K+A +++ E
Sbjct: 696 GNYTLLNVFLAIAVDNLANAQEL-TKDEEEMEEAANQKLALQKAKE 740
Score = 136 bits (342), Expect = 3e-31
Identities = 164/778 (21%), Positives = 322/778 (41%), Gaps = 145/778 (18%)
Query: 500 GAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFN----RRRC----------------RAA 539
GA GP G + + + K +++R R +N ++ C R
Sbjct: 28 GAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKY 87
Query: 540 VKSVT----FYWLVIVLVFLNTLTISSEHYNQPDW----LTQIQDIANKVLLALFTCEML 591
K +T F ++++ + N + ++ E + PD +++ D + +F E
Sbjct: 88 AKRITEWPPFEYMILATIIANCIVLALEQH-LPDGDKTPMSERLDDTEPYFIGIFCFEAG 146
Query: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIF 647
+K+ +LG +Y + +N D VV GI T + ++ + R VR+LR
Sbjct: 147 IKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT------LRAVRVLRPL 200
Query: 648 KVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF--------- 698
K+ SL ++ S++ +M + + LLLF I++F+++G++ + GKF+
Sbjct: 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
Query: 699 ------------------DETQTKR---------STFDNFPQALLTVFQILTGEDWNAVM 731
+T+ + + FDN A+LTVFQ +T E W ++
Sbjct: 261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query: 732 YDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791
Y+ A G + +YFI L I G++ +LN+ L + A ++E E
Sbjct: 321 YNTNDAAGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAK-------ERERVEN 368
Query: 792 KER-KKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEE 850
+ K+ R++ +E + N E I ++ + EED + + P DV +
Sbjct: 369 RRAFLKLRRQQQIERELNGYLE--WIFKAEEVMLA----EEDRNAEEKSPLDVLKRAATK 422
Query: 851 EEEEDEPEVPAGP-RPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHKLINHH 906
+ D G R + + A + G S+ + K R +++
Sbjct: 423 KSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQ 482
Query: 907 IFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLH 966
F ++L + L++ +A + T+ + ++ F +F E+ LKM G
Sbjct: 483 SFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLY-FAEFVFLGLFLTEMSLKMYGLGP--- 538
Query: 967 KGAFCRNYFNLLDM-LVVG--VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKH 1023
++ R+ FN D ++VG +V I+ + + +LR LR+LR + L++
Sbjct: 539 -RSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRN 597
Query: 1024 VVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYK 1083
+V + ++++I +++ + L +FA +G+QLF G+F DE +
Sbjct: 598 LVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDETPTT------------ 644
Query: 1084 DGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYN 1143
NFD +A++ +F + T E W A++Y I+S G +++
Sbjct: 645 -------------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS 685
Query: 1144 HRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELDKNQRQCVEYA 1199
S +FI+ + + ++N+F+ + E K+ + E NQ+ ++ A
Sbjct: 686 -----SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
Score = 135 bits (339), Expect = 6e-31
Identities = 100/366 (27%), Positives = 175/366 (47%), Gaps = 32/366 (8%)
Query: 68 TMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKP 127
T+ S + S ++ K++ A + P ++FCLS N +RR C IV +
Sbjct: 1092 TVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRY 1151
Query: 128 FDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLL 187
F++ IL+ I + +ALA P D N+ L+ ++Y F +FT E +K+I GLLL
Sbjct: 1152 FEVVILVVIALSSIALAAEDPVRTDSPR--NNALKYLDYIFTGVFTFEMVIKMIDLGLLL 1209
Query: 188 HPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRP 247
HP AY R+ WN+LDF++V L + + S GK +K+LR RVLRP
Sbjct: 1210 HPGAYFRDLWNILDFIVVSGALVAFAF----------SGSKGKDIN-TIKSLRVLRVLRP 1258
Query: 248 LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSD 307
L+ + +P L+ V + ++ ++ +L+I ++ + + I+A+I ++LF GK + D
Sbjct: 1259 LKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF---YCTDES 1315
Query: 308 IVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWT 367
E D + A + + ++DN +A+LT+F T EGW
Sbjct: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKK-------YDFHYDNVLWALLTLFTVSTGEGWP 1368
Query: 368 DVLYWVNDAI--------GWEWPW-VYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKA 418
VL DA G+ +++V ++ FF +N+ + ++ F ++ +K +
Sbjct: 1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMS 1428
Query: 419 RGDFQK 424
+K
Sbjct: 1429 ECSLEK 1434
Score = 122 bits (306), Expect = 4e-27
Identities = 75/292 (25%), Positives = 140/292 (47%), Gaps = 39/292 (13%)
Query: 1208 YIPKNPYQYKFWY--VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFT 1265
Y + ++F+ +V + F +++ ++ LNTLC+AM HY Q + + VF
Sbjct: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFL 522
Query: 1266 GVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
G+F EM LK+ P+ YF ++N FD +++GS+ +V + P S
Sbjct: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSS----------- 571
Query: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
I+ R R++R+ K+ +R L+ + + S +++ + L+ + ++A
Sbjct: 572 -------FGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA 624
Query: 1386 VIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1444
++GMQ+F G+ +D NF TFP A+L +F+ TGE W +M + + +
Sbjct: 625 LLGMQLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMYHGI-----ESQ 676
Query: 1445 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493
+ G F+ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 677 GGVSKG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 112 bits (281), Expect = 3e-24
Identities = 72/269 (26%), Positives = 140/269 (52%), Gaps = 10/269 (3%)
Query: 515 AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
AIS L+R + + + + V S F + ++ ++ LNT+ + + Y+ P +
Sbjct: 1443 AISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1502
Query: 575 QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEL-EIMSPL 633
N V ++F+ E ++K+ + G+ YF +N FD V G IT+ ++ E+ E + +
Sbjct: 1503 LKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFI 1562
Query: 634 GISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFG 693
+S R R R+ K+ R ++ L+ + + S K++ + LL+ + I++++GMQ+FG
Sbjct: 1563 NLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1622
Query: 694 GKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVC--- 749
D+T R + F F QAL+ +F+ TGE W+ +M + + C
Sbjct: 1623 NIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSD 1682
Query: 750 ---IYFI-ILFICGNYILLNVFLAIAVDN 774
YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1683 FAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 108 bits (271), Expect = 4e-23
Identities = 87/325 (26%), Positives = 154/325 (47%), Gaps = 22/325 (6%)
Query: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942
+ F+ S+ N +R ++ F +IL I+ + LA E P + + L
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 1002
+ F IF E +K+ G HKG++ RN +N++D +VV +++ + ++
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
Query: 1003 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1062
LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GKF+
Sbjct: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
Query: 1063 RCTDEAKSNPEECRGLFILYKDGDV---DSPVVRERIWQNSDF---NFDNVLSAMMALFT 1116
+ ++ E G F K+ + W +F NFDN+L A++ +F
Sbjct: 251 KACFPNSTDAEPV-GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
Query: 1117 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1176
T EGW +LY D+ G +Y FI III +FFM+N+ +G + F
Sbjct: 310 CITMEGWTDILYNTNDAAGNTWNWLY---------FIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 1177 EQGEK-EYKNCELDKNQRQCVEYAL 1200
++ E+ E + L ++Q +E L
Sbjct: 361 KERERVENRRAFLKLRRQQQIEREL 385
Score = 93.6 bits (231), Expect = 2e-18
Identities = 71/277 (25%), Positives = 128/277 (46%), Gaps = 37/277 (13%)
Query: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEML 591
RR C V F +++V++ L+++ +++E + D + + +FT EM+
Sbjct: 1140 RRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMV 1199
Query: 592 VKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIF 647
+KM LGL AYF L+N D VV G + + I R +R+LR
Sbjct: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPL 1259
Query: 648 KVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRST 707
K + L + ++NS+K++ ++L++ LF+ IF+++ +QLF GKF + ++K
Sbjct: 1260 KTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1319
Query: 708 ----------------------------FDNFPQALLTVFQILTGEDWNAVM---YDGIM 736
+DN ALLT+F + TGE W V+ D
Sbjct: 1320 RDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
Query: 737 AYGGPSSS-GMIVCIYFIILFICGNYILLNVFLAIAV 772
GPS M + I++++ F+ + +N+F+A+ +
Sbjct: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALII 1416
Score = 83.6 bits (205), Expect = 2e-15
Identities = 73/294 (24%), Positives = 130/294 (44%), Gaps = 65/294 (22%)
Query: 127 PFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLL 186
PF+ FI+ I N V L + D L+ + F +F++E LKIIA+G+L
Sbjct: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
Query: 187 LHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLR 246
Y R+ WN+ DFV V+ + +++ ++ + N S LR FR R
Sbjct: 1529 ----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF----------LRLFRAAR 1574
Query: 247 PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS 306
++L+ +++++L + +++ L ++ LL+ + IYAIIG+++F
Sbjct: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------G 1622
Query: 307 DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGW 366
+I ++D + + NF F A++ +F+ T E W
Sbjct: 1623 NIALDDDTSINRHN-------------------------NFRTFLQALMLLFRSATGEAW 1657
Query: 367 TDVLY--WVNDA---------IGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
+++ N A G ++ + YFVS I L SF +LNL + V+ F
Sbjct: 1658 HEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 70.9 bits (172), Expect = 1e-11
Identities = 66/304 (21%), Positives = 122/304 (40%), Gaps = 82/304 (26%)
Query: 1226 PFEYMMFVLIMLNTLCLAMQHY---EQSKMFNDAMDILNMVFTGVFTVEMVLKVIA---- 1278
PFEYM+ I+ N + LA++ + ++ +D F G+F E +K+IA
Sbjct: 96 PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1279 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFF 1338
F Y + WN D ++V+ I+ A ++ D +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------------------------LRTL 191
Query: 1339 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------ 1392
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 192 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
Query: 1393 -----------------GKVA---MRDNNQINRN---------NNFQTFPQAVLLLFRCA 1423
GK A + + + R NF A+L +F+C
Sbjct: 252 ACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCI 311
Query: 1424 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVI 1483
T E W +I+ YN + G+ + +YFI ++ +F ++NL + V+
Sbjct: 312 TMEGWTDIL--------------YNTND--AAGNTWNWLYFIPLIIIGSFFMLNLVLGVL 355
Query: 1484 MDNF 1487
F
Sbjct: 356 SGEF 359
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 727 bits (1877), Expect = 0.0
Identities = 380/816 (46%), Positives = 539/816 (66%), Gaps = 40/816 (4%)
Query: 844 PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 903
P+ E E E+E+E E + +R + M +P S+ FI S TNPIR CH ++
Sbjct: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
Query: 904 NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 963
N F IL+ I SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM G
Sbjct: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
Query: 964 FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 1016
L G++ R+ +N+LD +VV +LV+F + ++ I +K LRVLRVLRPL+ I
Sbjct: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
Query: 1017 RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1076
R LK V CV +++ + NI+IV L F+FA I VQLFKGKF+ CTD +K +EC
Sbjct: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
Query: 1077 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1136
G ++ D + + V+ R W+ +F++DN++ A++ LFTVST EGWP +L ++D E
Sbjct: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1137 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1196
+ GP ++R+E+SIF+++Y ++ FF +NIFV +I+TFQEQG+K + C L+KN+R C+
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
Query: 1197 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1254
++A+ A+PL RY+P+N +QY+ W+ V S FEY + +I LNT+ L M++Y +
Sbjct: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
Query: 1255 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTES 1314
A+ LN+ FT VF++E VLKVIAF YF D WN FD + VIGSI ++ L T+S
Sbjct: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIIL-----TDS 1562
Query: 1315 ENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1374
+ V ++ +++F +LFR RL+KLL +G IR LLWTF++SF+ALPYV
Sbjct: 1563 KLV-----------NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1611
Query: 1375 LLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1434
LLIAMLFFIYA+IGMQ+FG + + + + INR+NNF++F +++LLFR ATGEAWQEIML+
Sbjct: 1612 LLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLS 1671
Query: 1435 CLPGKLCDPESDYNPG--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1492
CL K C+P++ G E CG++ A VYF+SF C+FL++NLFVAVIMDNF+YLTR
Sbjct: 1672 CLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTR 1731
Query: 1493 DWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1552
D SILGPHHLDEF R+W+EYD A GRI + ++ +L + PPLG GK CP +VA KRLV
Sbjct: 1732 DSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLV 1791
Query: 1553 AMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLL 1609
MNMP+ D TV F +TL AL+RTAL IK + +Q + EL+ IW S K+L
Sbjct: 1792 LMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKML 1851
Query: 1610 DQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQ 1645
D +VP ++TVGK YA +I DY+++ K +K++
Sbjct: 1852 DLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
Score = 619 bits (1595), Expect = e-176
Identities = 363/791 (45%), Positives = 481/791 (60%), Gaps = 63/791 (7%)
Query: 33 PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90
P SG+G + Q + + T + S QAA +A+ A+TM+ P PV RQ
Sbjct: 12 PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
Query: 91 SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150
R+LF +N +R+ +++W PF+ IL I ANC+ LA+ P
Sbjct: 65 VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
Query: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210
EDD + LEK E F+ IF E +KI+A G + H +Y+RNGWN++DF++V+ G+
Sbjct: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
Query: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270
+ T T H D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
Query: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329
LL I LL+ F I+++AIIGLE + GK+H+ CF +S I+ DP PC G C A
Sbjct: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
Query: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSL 389
G EC+ W+GPN GIT FDN FA+LTVFQCITMEGWT VLY NDA+G W W+YF+ L
Sbjct: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
Query: 390 IILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448
II+GSFFVLNLVLGVLSGEF+KERE+ + R F KLR +QQ+E +L GY WI +AE++
Sbjct: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
Query: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAG 505
EN+ G E R ++ S TE++ ++ + G+ A+A
Sbjct: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGT--------PLARAS 446
Query: 506 PSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 565
+ G + + K R R R VKS FYW+V+ LV LNT ++ H+
Sbjct: 447 IKSAKVDGVSYFRHK--------ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH 498
Query: 566 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 625
NQP WLT + A + L LF EM +KMY +G + YF S FN FD V G I E +
Sbjct: 499 NQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWA 558
Query: 626 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 685
+ GISV R +RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+
Sbjct: 559 IFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFA 618
Query: 686 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 745
LLGMQLFGG+FNF++ T + FD FP A++TVFQILTGEDWN VMY+GI + GG SSG
Sbjct: 619 LLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSG 676
Query: 746 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLEN 805
M IYFI+L + GNY LLNVFLAIAVDNLA+A+ L T ++E EE +K A +++ E
Sbjct: 677 MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEV 735
Query: 806 KKNNKPEVNQI 816
+ P + I
Sbjct: 736 SPMSAPNMPSI 746
Score = 189 bits (479), Expect = 3e-47
Identities = 171/699 (24%), Positives = 301/699 (43%), Gaps = 141/699 (20%)
Query: 885 AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942
+ FI + N +R KLI+ F +IL I+ + LA E P + + L
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 1000
+ F IF E +K+ G HKG++ RN +N++D +VV G+ L + G + +
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
Query: 1001 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1060
+ LR +RVLRPL+ ++ L+ V++ + A+ + I ++ MFA IG++ + GK
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
Query: 1061 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1111
+R S P C +G Y+ D P + FDN+L A+
Sbjct: 247 LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
Query: 1112 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1169
+ +F T EGW +LY D+ +G +N ++FI III +FF++N+ +G
Sbjct: 300 LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
Query: 1170 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1188
F+ + Q+Q E+E
Sbjct: 351 SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
Query: 1189 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1219
D + CV+ + PL R K+ +++K
Sbjct: 411 RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
Query: 1220 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1279
++V S F +++ L+ LNT C+A+ H+ Q + + +F G+F +EM LK+
Sbjct: 471 HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
Query: 1280 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1339
P+ YF ++N FD + +GSI +V + PG S I+ R
Sbjct: 531 GPRLYFHSSFNCFDFGVTVGSIFEVVWA-------------IFRPGTS-----FGISVLR 572
Query: 1340 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRD 1399
R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+FG +
Sbjct: 573 ALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFN 630
Query: 1400 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGS 1457
N + NF TFP A++ +F+ TGE W E+M YN +
Sbjct: 631 FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSG 676
Query: 1458 NFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493
++ +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 677 MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 134 bits (336), Expect = 1e-30
Identities = 102/381 (26%), Positives = 183/381 (48%), Gaps = 50/381 (13%)
Query: 82 QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141
++K+Q K +K+ P ++F S NPIRRAC IV + F++ ILL I A+ +
Sbjct: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
Query: 142 ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201
ALA P + N L +Y F +FT E +K+I GL+L +Y R+ WN+LD
Sbjct: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
Query: 202 FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261
FV+V+ L + L +G + + +K+LR RVLRPL+ + +P L+ V
Sbjct: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
Query: 262 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321
+ ++ ++ + +I ++ + I+A+I ++LF GK FF +D + +
Sbjct: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
Query: 322 NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376
++C N + + G ++DN +A+LT+F T EGW VL D
Sbjct: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
Query: 377 IGWE---------WPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRE 427
+ +++V ++ FF +N+ + ++ F ++ GD K+ E
Sbjct: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMME 1435
Query: 428 KQQLEEDLKGYLDWITQAEDI 448
+ LE++ + +D+ A+ +
Sbjct: 1436 ECSLEKNERACIDFAISAKPL 1456
Score = 131 bits (330), Expect = 6e-30
Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)
Query: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 589
R+ + + F ++++ + N + ++ E + D T + K + +F E
Sbjct: 79 RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
Query: 590 MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645
+K+ +LG +Y + +N D VV GI T + + + R VR+LR
Sbjct: 139 AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
Query: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 697
K+ SL ++ S++ +M + + LLLF I++F+++G++ + GK +
Sbjct: 197 PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
Query: 698 -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 732
FD + FDN A+LTVFQ +T E W V+Y
Sbjct: 257 GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
Query: 733 DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 792
+ A G + +YFI L I G++ +LN+ L + A ++E E +
Sbjct: 317 NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
Query: 793 ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 834
K+ R++ +E + N +K E +A + + TI R E
Sbjct: 365 RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
Query: 835 KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 894
+D DE V ++ ++K +G ++F K
Sbjct: 425 RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
Query: 895 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 954
+R+ ++ +F ++L + L++A +A + +L Y ++ F +F +E+
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
Query: 955 LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 1011
LKM G L + + FN D V S+ V + I S + +LR LR+LR
Sbjct: 524 SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
Query: 1012 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1071
+ L+++V + ++++I +++ + L +FA +G+QLF G+F
Sbjct: 580 FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
Query: 1072 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1131
+ DG + NFD +A+M +F + T E W ++Y I
Sbjct: 631 ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
Query: 1132 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1189
S G +++ +I+FI+ + + ++N+F+ + E K+ + E
Sbjct: 668 RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
Query: 1190 KNQRQCVEYALKARPL 1205
NQ+ ++ A + P+
Sbjct: 723 FNQKHALQKAKEVSPM 738
Score = 104 bits (259), Expect = 1e-21
Identities = 69/276 (25%), Positives = 136/276 (49%), Gaps = 16/276 (5%)
Query: 515 AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574
AIS L+R + + R V S +F + ++ ++ LNT+ + ++Y+ P
Sbjct: 1450 AISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELA 1509
Query: 575 QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634
N +F+ E ++K+ + G YF +N FD V G ITE IL + ++++ G
Sbjct: 1510 LKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSG 1569
Query: 635 --ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF 692
+S + R R+ K+ R ++ L+ + + S K++ + LL+ + I++++GMQ+F
Sbjct: 1570 FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Query: 693 GG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG------GPSSSG 745
G K + + + + F +F +L+ +F+ TGE W +M + G PS
Sbjct: 1630 GNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQN 1689
Query: 746 M-------IVCIYFIILFICGNYILLNVFLAIAVDN 774
+ +YF+ ++++LN+F+A+ +DN
Sbjct: 1690 ENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
Score = 84.0 bits (206), Expect = 2e-15
Identities = 75/292 (25%), Positives = 133/292 (45%), Gaps = 63/292 (21%)
Query: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVL-------LAL 585
RR C V F +++++ +++ +++E LT + NKVL +
Sbjct: 1143 RRACHYIVNLRYFEMCILLVIAASSIALAAED----PVLTNSE--RNKVLRYFDYVFTGV 1196
Query: 586 FTCEMLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG------- 634
FT EM++KM GL +YF L+N D VV G LV + + LG
Sbjct: 1197 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGA-----LVAFALANALGTNKGRDI 1251
Query: 635 --ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF 692
I R +R+LR K + L + ++ S+K++ ++L++ LF+ IF+++ +QLF
Sbjct: 1252 KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLF 1311
Query: 693 GGKFNFDETQTKRST----------------------------FDNFPQALLTVFQILTG 724
GKF + +K + +DN ALLT+F + TG
Sbjct: 1312 KGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTG 1371
Query: 725 EDWNAVMYDGIMAY---GGPS-SSGMIVCIYFIILFICGNYILLNVFLAIAV 772
E W V+ + GPS S+ M + I++++ F+ + +N+F+A+ +
Sbjct: 1372 EGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALII 1423
Score = 82.8 bits (203), Expect = 3e-15
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 68/267 (25%)
Query: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220
L+ + AF ++F++E LK+IA+G L Y R+ WN+ DF+ VI + +IL
Sbjct: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
Query: 221 TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280
+ + GF++ L+ FR R ++L+ +++++L + +++ L ++ LL+
Sbjct: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
Query: 281 VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340
+ IYAIIG+++F +I +E+ S R
Sbjct: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
Query: 341 NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------------------NDAIGWEWP 382
NF +F +++ +F+ T E W +++ N+ G +
Sbjct: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
Query: 383 WVYFVSLIILGSFFVLNLVLGVLSGEF 409
+VYFVS I SF +LNL + V+ F
Sbjct: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 420 bits (1080), Expect = e-117
Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)
Query: 549 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 608
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 609 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 668
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
Query: 669 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 722
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
Query: 723 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 776
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
Query: 777 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 809
D +N Q K + E +K RK E L NKK++
Sbjct: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
Query: 810 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 847
+ I +S K +D+ +P VP VGE
Sbjct: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
Query: 848 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 868
EE +E+ E EPE P
Sbjct: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
Query: 869 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 925 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 983
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
Query: 984 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1040
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
Query: 1041 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1091
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
Query: 1092 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1151
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
Query: 1152 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1203
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
Query: 1204 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1263
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1264 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1323
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E
Sbjct: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
Query: 1324 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++
Sbjct: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
Query: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1438
FIYA+ GM F V + I+ NF+TF +++ LF+ T W ++ L
Sbjct: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query: 1439 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1495
CDP+ D+ PG CG+ + I +F+S+ ++ +++N+++AVI++NF T + +
Sbjct: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
Query: 1496 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1554
L + F +W ++DP+A I+ + + PPL K P++V +L+AM
Sbjct: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
Query: 1555 NMPLNSDGTVMFNATLFALVRTAL 1578
++P+ S + LFA + L
Sbjct: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
Score = 149 bits (375), Expect = 4e-35
Identities = 109/376 (28%), Positives = 180/376 (47%), Gaps = 73/376 (19%)
Query: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
Query: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ G
Sbjct: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVNLG 211
Query: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
Query: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
+A+IGL+LF+G + C FF +S
Sbjct: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
Query: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
Query: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
+T + W ++ A G + ++FV +I LGSF+++NL+L V++ + +E+ +A
Sbjct: 381 MTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
Query: 421 DFQKLREKQQLEEDLK 436
QK E QQ+ E LK
Sbjct: 439 AEQKEAEFQQMLEQLK 454
Score = 133 bits (335), Expect = 2e-30
Identities = 97/328 (29%), Positives = 156/328 (47%), Gaps = 41/328 (12%)
Query: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
Query: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
Query: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
Query: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
Query: 351 AFAMLTVFQCITMEGWTDVLYWVNDAIGWE---------WPWVYFVSLIILGSFFVLNLV 401
L++ Q T +GW D++Y D+ E + ++YFV II GSFF LNL
Sbjct: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
Query: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
+GV+ F+++++K + F +K+
Sbjct: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
Score = 120 bits (302), Expect = 1e-26
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)
Query: 1221 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1279
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
Query: 1280 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1339
P YF + WN FD IV S++++ L+ + ++ R
Sbjct: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
Query: 1340 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1394
FR++R+ KL + L+ S AL + L++A++ FI+AV+GMQ+FGK
Sbjct: 851 SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
Query: 1395 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1454
V N+ + F + L++FR GE W E M C+
Sbjct: 911 VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
Query: 1455 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
G + F+ ++ +++NLF+A+++ +F
Sbjct: 954 AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
Score = 100 bits (249), Expect = 2e-20
Identities = 78/320 (24%), Positives = 140/320 (43%), Gaps = 38/320 (11%)
Query: 528 WNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLAL 585
WN R+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +
Sbjct: 1195 WNL--RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI 1252
Query: 586 FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645
F EML+K + G Q YF + + D +V + L I R +R LR
Sbjct: 1253 FILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------- 696
+ + + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTG 1372
Query: 697 ---------NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI 735
N+ E QT R FDN L++ Q+ T + W +MY +
Sbjct: 1373 EMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAV 1432
Query: 736 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791
+ + + +YF+I I G++ LN+F+ + +DN + Q E
Sbjct: 1433 DSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1492
Query: 792 KERKKIARKESLENKKNNKP 811
+++K + L +KK KP
Sbjct: 1493 EQKKYYNAMKKLGSKKPQKP 1512
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 815 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 869
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
Query: 870 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
Query: 925 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 984
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
Query: 985 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1044
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 201 FAYVTEFVNLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
Query: 1045 LQFMFACIGVQLFKG 1059
+FA IG+QLF G
Sbjct: 258 CLSVFALIGLQLFMG 272
Score = 82.0 bits (201), Expect = 6e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
Query: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
Query: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
Query: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
+K C C S +C W + +F + L
Sbjct: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
Query: 357 VFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412
VF+ + E W + ++ + G F+ ++++G+ VLNL L +L FS +
Sbjct: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Score = 79.7 bits (195), Expect = 3e-14
Identities = 82/398 (20%), Positives = 161/398 (40%), Gaps = 92/398 (23%)
Query: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
Query: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
Query: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
Query: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
Query: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------ 373
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
Query: 374 ------------------NDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS---KE 412
N ++G +FVS II+ V+N+ + V+ FS +E
Sbjct: 1730 DCDPDKDHPGSSVKGDCGNPSVG----IFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1785
Query: 413 REKAKARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
+ + DF+ E ++ + D ++++ ++ D
Sbjct: 1786 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
Score = 53.9 bits (128), Expect = 2e-06
Identities = 44/187 (23%), Positives = 84/187 (44%), Gaps = 34/187 (18%)
Query: 1210 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1269
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
Query: 1270 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
E ++K++A + + D WN D ++ + + TE N+ G
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVNL-------G 211
Query: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
N ++ R FRV+R +K +S G++T++ I+S + L V +L ++A
Sbjct: 212 N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query: 1386 VIGMQMF 1392
+IG+Q+F
Sbjct: 264 LIGLQLF 270
Score = 51.2 bits (121), Expect = 1e-05
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 20/189 (10%)
Query: 513 GQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT---FYWLVIVLVFLNTLTISSEHYNQPD 569
G+AIS+ + FN R + A+K + F L++ + N + ++ N PD
Sbjct: 97 GKAISRFSATPALYILTPFNPIR-KLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPD 153
Query: 570 WLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILV 625
W ++ ++T E L+K+ + G + +N D V+ T
Sbjct: 154 WTKNVE----YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVI------TFAY 203
Query: 626 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 685
E ++ +S R R+LR K L +V +L+ S+K ++ +++L + +F+
Sbjct: 204 VTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query: 686 LLGMQLFGG 694
L+G+QLF G
Sbjct: 264 LIGLQLFMG 272
Score = 47.4 bits (111), Expect = 2e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 765
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
Query: 766 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 822
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 37.0 bits (84), Expect = 0.21
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 1103 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1162
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
Query: 1163 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1201
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,812,453
Number of Sequences: 37866
Number of extensions: 4047103
Number of successful extensions: 28078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 19936
Number of HSP's gapped (non-prelim): 3226
length of query: 2181
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2063
effective length of database: 13,779,330
effective search space: 28426757790
effective search space used: 28426757790
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.