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Search of human proteins with 4502503
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502503 complement component 4 binding protein, alpha chain p... 1290 0.0
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 251 1e-66
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 248 9e-66
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 228 2e-59
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 228 2e-59
gi|148886654 polydom [Homo sapiens] 218 2e-56
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 204 1e-52
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 196 4e-50
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 176 4e-44
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 176 4e-44
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 174 2e-43
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 174 2e-43
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 169 5e-42
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 169 5e-42
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 169 5e-42
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 168 1e-41
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 168 1e-41
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 168 1e-41
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 167 2e-41
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 167 2e-41
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 167 3e-41
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 167 3e-41
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 165 1e-40
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 165 1e-40
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 161 2e-39
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 158 1e-38
gi|168693643 decay accelerating factor for complement isoform 2 ... 154 2e-37
gi|10835143 decay accelerating factor for complement isoform 1 p... 154 2e-37
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 151 1e-36
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 146 6e-35
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 1290 bits (3337), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAA 60
MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAA
Sbjct: 1 MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAA 60
Query: 61 PMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR 120
PMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR
Sbjct: 61 PMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR 120
Query: 121 NGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPD 180
NGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPD
Sbjct: 121 NGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPD 180
Query: 181 IRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCR 240
IRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCR
Sbjct: 181 IRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCR 240
Query: 241 KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCI 300
KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCI
Sbjct: 241 KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCI 300
Query: 301 NLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGC 360
NLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGC
Sbjct: 301 NLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGC 360
Query: 361 EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTP 420
EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTP
Sbjct: 361 EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTP 420
Query: 421 SCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQC 480
SCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQC
Sbjct: 421 SCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQC 480
Query: 481 KALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW 540
KALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW
Sbjct: 481 KALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW 540
Query: 541 ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL 597
ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL
Sbjct: 541 ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL 597
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 251 bits (641), Expect = 1e-66
Identities = 169/517 (32%), Positives = 240/517 (46%), Gaps = 63/517 (12%)
Query: 74 GTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132
G ++ Y+C GY+ + + C S G+W C RC+ G NG+V+ L
Sbjct: 176 GLSVTYSCESGYLLV-GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRV 234
Query: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENF 192
G F C EG+ L G +SRC + +GV W+ +P CE + C PP I NGRH G
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLA 293
Query: 193 -YAYGFSVTYSCDP------RFSLLGHASISCTVENETIGVWRPSPPTCEKIT----CRK 241
+YG VTY+CDP F L+G +++ CTV+++ G W P CE T C
Sbjct: 294 NVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH 353
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCIN 301
P + G MVSG Y Y DT++F C GF L+GS I C+A W PS P CE C
Sbjct: 354 PQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQA 412
Query: 302 LPDIPHASWETYPRPTKEDVYVV----GTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-P 356
P+I + KED ++V GT ++Y C+PGY +E ++ C WT P
Sbjct: 413 PPNILNGQ--------KEDRHMVRFDPGTSIKYSCNPGYVLVGEE--SIQCTSEGVWTPP 462
Query: 357 YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGD 412
C+ C QH+ RP +++ SC E + S CQG
Sbjct: 463 VPQCKVAACEATGRQLLTKPQHQFVRP----------DVNSSCGEGYKLSGSVYQECQGT 512
Query: 413 GTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF-FKEEIIYECDKG------YILVGQA 464
W C +I C PP I +G + SS F + + Y C+ G + L+G++
Sbjct: 513 IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572
Query: 465 KLSCSYSH-----WSAPAPQCK-----ALCRKPELVNG-RLSVDKDQYVEPENVTIQCDS 513
+ C+ + WS PAP CK C + NG ++S + Y + VT +C S
Sbjct: 573 TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYS 632
Query: 514 GYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVL 550
G+ + G I C + TW PE+P CE ET + Q L
Sbjct: 633 GFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSL 669
Score = 202 bits (515), Expect = 5e-52
Identities = 150/531 (28%), Positives = 228/531 (42%), Gaps = 61/531 (11%)
Query: 44 PAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV 103
P C PP + D + RF GT++KY+C PGYV +++ C S+G W
Sbjct: 404 PVCEKECQAPPNILNGQKEDRHMV--RFDPGTSIKYSCNPGYVLV-GEESIQCTSEGVWT 460
Query: 104 YNT-FCIYKRCRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGV 161
C C G Q+ K F + SC EG+ L GS C+ +
Sbjct: 461 PPVPQCKVAACEATGR----QLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGT---I 513
Query: 162 GWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDP------RFSLLGHAS 214
W + C+ + C PPP I NG H+G + YG +VTY+C+P FSL+G ++
Sbjct: 514 PWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST 573
Query: 215 ISCTVENETIGVWRPSPPTCE----KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKG 270
I CT ++ G W P C+ + C +++G +SG Y Y DT+ FKC G
Sbjct: 574 IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSG 633
Query: 271 FVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRY 330
F L+GSS I C AD+ W+P P CE +C H P V +V T
Sbjct: 634 FTLKGSSQIRCKADNTWDPEIPVCEKETC------QHVRQSLQELPAGSRVELVNT---- 683
Query: 331 RCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEAL-CCPEPKLNNGEITQHRKSRPANHCV 388
C GY+ T +N W C+ + C P P + NG+ T
Sbjct: 684 SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN------ 737
Query: 389 YFYGDEISFSC--------HETSRFSAICQGDGTWSPRTPSC---GDICNFP-PKIAHGH 436
+ YG+E+S+ C + + + +G G+WS +P C + P P++ HG+
Sbjct: 738 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGY 797
Query: 437 YKQSSSYSFFKEEIIY-ECDKGYILVGQAKLSCSYSH-WSAPAPQC--KALC---RKPEL 489
+ ++ +I+Y +C+ G+I+ G + C + W P C KA P+
Sbjct: 798 KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKT 857
Query: 490 VNGRLSVDKDQYVEP-ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
NG + P ++ CD GY +VG + C+ TW P C+
Sbjct: 858 PNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908
Score = 172 bits (437), Expect = 6e-43
Identities = 159/546 (29%), Positives = 224/546 (41%), Gaps = 78/546 (14%)
Query: 39 IAALLPAVLG-NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97
+A + P VLG +CG PP + I+ T GT ++Y+C G R ++L C
Sbjct: 11 LALVAPGVLGISCGSPPPILNGR---ISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCI 66
Query: 98 S----DGEW-----VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIG 148
+ DG W F Y C P ++ T G + F+C F + G
Sbjct: 67 TKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNG 126
Query: 149 STTSRCEVQDRGVGWSHP-LPQCEIV---KCKPPPDIRNGRHSGEE-NFYAYGFSVTYSC 203
+ + C+ + W LP C V +C P I NG H+ E A G SVTYSC
Sbjct: 127 NKSVWCQANNM---WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSC 183
Query: 204 DPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSG---FGPIYNYK 260
+ + L+G I+C + G W PPTCE+ C+ S G +G PI
Sbjct: 184 ESGYLLVGEKIINCL----SSGKWSAVPPTCEEARCK----SLGRFPNGKVKEPPILRVG 235
Query: 261 DTIVFKCQKGFVLRGSSVIHCDADSK---WNPSPPACEPNSCINLPDIPHASWETYPRPT 317
T F C +G+ L+G C + W P CE C + P I + R
Sbjct: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG------RHI 288
Query: 318 KEDVYVV--GTVLRYRCHPGYKPTTD-----EPT---TVICQKNLRWT-PYQGCE----A 362
+ V G+++ Y C P + + E T TV QK W+ P CE A
Sbjct: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
Query: 363 LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPR 418
+ CP P++ G + +K R Y Y D + F+C C GTW P
Sbjct: 349 VQCPHPQILRGRMVSGQKDR------YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPS 402
Query: 419 TPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYILVGQAKLSC-SYSHWSAP 476
P C C PP I +G + F I Y C+ GY+LVG+ + C S W+ P
Sbjct: 403 APVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP 462
Query: 477 APQCK-ALCRKPELVNGR--LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYP 533
PQCK A C GR L+ + Q+V P+ V C GY + G C G W+
Sbjct: 463 VPQCKVAACE----ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLSGSVYQECQGTIPWFM 517
Query: 534 EVPKCE 539
E+ C+
Sbjct: 518 EIRLCK 523
Score = 168 bits (425), Expect = 1e-41
Identities = 139/507 (27%), Positives = 216/507 (42%), Gaps = 61/507 (12%)
Query: 113 CRHPGELRNGQVEI-KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQC 170
C P + NG++ T ++ G+ I +SCS F LIG + C +D+ G W P P+C
Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
Query: 171 EI---VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227
E P P + G Y +G SVT++C FS+ G+ S+ C N +W
Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN----MW 138
Query: 228 RPSP-PTCEKI---TCRKPDVSH-----GEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
P+ PTC + C + H E V P ++ + C+ G++L G +
Sbjct: 139 GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGL----SVTYSCESGYLLVGEKI 194
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYK- 337
I+C + KW+ PP CE C +L P+ + P + VG + C GY+
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPP------ILRVGVTANFFCDEGYRL 248
Query: 338 PTTDEPTTVICQKNLRWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEIS 396
VI + + WT CE + CP P + NG +H + AN YG ++
Sbjct: 249 QGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNG---RHIGNSLAN---VSYGSIVT 302
Query: 397 FSC--------------HETSRFSAICQGDGTWSPRTPSC---GDICNFP-PKIAHGHY- 437
++C T R + Q GTWS P C P P+I G
Sbjct: 303 YTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV 362
Query: 438 -KQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKALCR-KPELVNGRL 494
Q Y+ + + +I+ C G+ L G ++ C + W AP C+ C+ P ++NG+
Sbjct: 363 SGQKDRYT-YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQK 421
Query: 495 SVDKDQYVEP-ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGK 553
+P ++ C+ GY +VG +SI C+ W P VP+C+ E + L K
Sbjct: 422 EDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK 481
Query: 554 RLMQCLPNPEDVKMALEVYKLSLEIEQ 580
Q + P+ E YKLS + Q
Sbjct: 482 PQHQFV-RPDVNSSCGEGYKLSGSVYQ 507
Score = 158 bits (399), Expect = 2e-38
Identities = 153/598 (25%), Positives = 228/598 (38%), Gaps = 123/598 (20%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHS-----TQTLTCNSD----G 100
C PP + + +L + G+ + YTC P + TL C D G
Sbjct: 276 CPSPPPILNGRHIGNSLANVSY--GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTG 333
Query: 101 EWV-------YNTFCIYKRCRHPGELRNGQVEIKTD-LSFGSQIEFSCSEGFFLIGSTTS 152
W +T + +C HP LR V + D ++ + F+C GF L GS
Sbjct: 334 TWSGPAPRCELSTSAV--QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQI 391
Query: 153 RCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENF-YAYGFSVTYSCDPRFSLLG 211
RC Q W P CE +C+ PP+I NG+ + G S+ YSC+P + L+G
Sbjct: 392 RCNAQGT---WEPSAPVCE-KECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVG 447
Query: 212 HASISCTVENETIGVWRPSPPTCEKITCR---------------KPDV--SHGEMVSGFG 254
SI CT E GVW P P C+ C +PDV S GE G
Sbjct: 448 EESIQCTSE----GVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSG 503
Query: 255 PIYN----------------------------------------YKDTIVFKCQKG---- 270
+Y Y T+ + C G
Sbjct: 504 SVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERG 563
Query: 271 --FVLRGSSVIHCDADSK----WNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVV 324
F L G S I C ++ + W+ P C+ + H + Y KE Y
Sbjct: 564 VEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA-NGYKISGKEAPYFY 622
Query: 325 GTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRP 383
+ ++C+ G+ T + + C+ + W P CE C + Q + P
Sbjct: 623 NDTVTFKCYSGF--TLKGSSQIRCKADNTWDPEIPVCEKETCQH-------VRQSLQELP 673
Query: 384 ANHCVYFYGDEISFSCHETSRFSAICQG--DGTWSPRTPSCGDI-CNFPPKIAHGHYKQS 440
A V T +CQ +G W + P C I C+ PP I +G +
Sbjct: 674 AGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM 733
Query: 441 SSYSF-FKEEIIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCK-----ALCRKPEL 489
+ +F + E+ YECD+G+ L+G+ KL C + WS P+PQC C PE+
Sbjct: 734 MAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV 793
Query: 490 VNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGC 546
+G +L+ Y + V + C+ G+ + G + I C + TW P VP C + GC
Sbjct: 794 KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 851
Score = 151 bits (381), Expect = 2e-36
Identities = 115/413 (27%), Positives = 180/413 (43%), Gaps = 43/413 (10%)
Query: 173 VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPP 232
+ C PP I NGR S A G + YSC F L+G S+ C +++ G W P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 233 TCEKI----TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWN 288
CE +C +P V G + G P Y + D++ F C+ F + G+ + C A++ W
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
Query: 289 PSP-PACE---PNSCINLPDIPHASWETYPRPTKEDVYVV--GTVLRYRCHPGYKPTTDE 342
P+ P C P C LP I + T E+V + G + Y C GY ++
Sbjct: 140 PTRLPTCVSVFPLECPALPMIHNG------HHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
Query: 343 PTTVICQKNLRWT--PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
+ C + +W+ P EA C + NG++ + R +F +
Sbjct: 194 --IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
Query: 401 ETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHG-HYKQSSSYSFFKEEIIYECDK-- 456
+SR + G G + P C +I C PP I +G H S + + + Y CD
Sbjct: 252 PSSR--CVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
Query: 457 ----GYILVGQAKLSCSYSH-----WSAPAPQCK-----ALCRKPELVNGRL-SVDKDQY 501
+IL+G++ L C+ WS PAP+C+ C P+++ GR+ S KD+Y
Sbjct: 310 EEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRY 369
Query: 502 VEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKR 554
+ V C G+ + G + I C+ TW P P CE E + +L G++
Sbjct: 370 TYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC-QAPPNILNGQK 421
Score = 107 bits (266), Expect = 4e-23
Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 29/267 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSD----GEWVY 104
+C PPP + + F G + Y C G+ + L C SD G W
Sbjct: 718 HCHPPPVI--VNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEKKLQCRSDSKGHGSWSG 774
Query: 105 -NTFCIYK----RCRHPGELRNGQVEIKTDLSFGSQ--IEFSCSEGFFLIGSTTSRCEVQ 157
+ C+ RC +P E+++G KT ++ + C+ GF + GS RC
Sbjct: 775 PSPQCLRSPPVTRCPNP-EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTD 833
Query: 158 DRGVGWSHPLPQC---EIVKCKPPPDIRNGRHSGEENF-YAYGFSVTYSCDPRFSLLGHA 213
+ W +P C + C PPP NG H+G ++ G S+ YSCD + L+G A
Sbjct: 834 NT---WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
Query: 214 SISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP--IYNYKDTIVFKCQKGF 271
+ CT E G W P C+++ C P G + G P +Y Y + +C+ G+
Sbjct: 891 LLLCTHE----GTWSQPAPHCKEVNCSSPADMDG-IQKGLEPRKMYQYGAVVTLECEDGY 945
Query: 272 VLRGSSVIHCDADSKWNPSPPACEPNS 298
+L GS C +D +WNP C S
Sbjct: 946 MLEGSPQSQCQSDHQWNPPLAVCRSRS 972
Score = 105 bits (262), Expect = 1e-22
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 25/291 (8%)
Query: 80 TCLPGY-VRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVE--IKTDLSFGSQ 135
+C GY + H+ Q +G W C C P + NG+ + + +G++
Sbjct: 684 SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743
Query: 136 IEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQC----EIVKCKPPPDIRNG-RHSGE 189
+ + C +GF+L+G +C +G G WS P PQC + +C P P++++G + +
Sbjct: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC-PNPEVKHGYKLNKT 802
Query: 190 ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK---ITCRKPDVS- 245
+ Y++ V C+P F + G I C +N W P PTC K I C P +
Sbjct: 803 HSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDN----TWVPGVPTCIKKAFIGCPPPPKTP 858
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDI 305
+G G ++ +I++ C +G++L G +++ C + W+ P C+ +C + D+
Sbjct: 859 NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 918
Query: 306 PHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
PR +Y G V+ C GY + CQ + +W P
Sbjct: 919 DGIQKGLEPR----KMYQYGAVVTLECEDGYMLEGSPQSQ--CQSDHQWNP 963
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/135 (26%), Positives = 54/135 (40%), Gaps = 11/135 (8%)
Query: 423 GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPA 477
G C PP I +G S+ I Y C + L+G+ L C W PA
Sbjct: 20 GISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPA 79
Query: 478 PQCK-----ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
P+C+ + C +P + G Y ++VT C + + + G +S+ C N W
Sbjct: 80 PKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
Query: 533 P-EVPKCEWETPEGC 546
P +P C P C
Sbjct: 140 PTRLPTCVSVFPLEC 154
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 248 bits (634), Expect = 9e-66
Identities = 167/514 (32%), Positives = 239/514 (46%), Gaps = 67/514 (13%)
Query: 74 GTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132
G ++ Y+C GY+ + + C S G+W C RC+ G NG+V+ L
Sbjct: 176 GLSVTYSCESGYLLV-GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRV 234
Query: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENF 192
G F C EG+ L G +SRC + +GV W+ +P CE + C PP I NGRH G
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLA 293
Query: 193 -YAYGFSVTYSCDP------RFSLLGHASISCTVENETIGVWRPSPPTCEKIT----CRK 241
+YG VTY+CDP F L+G +++ CTV+++ G W P CE T C
Sbjct: 294 NVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH 353
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCIN 301
P + G MVSG Y Y DT++F C GF L+GS I C+A W PS P CE C
Sbjct: 354 PQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQA 412
Query: 302 LPDIPHASWETYPRPTKEDVYVV----GTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-P 356
P+I + KED ++V GT ++Y C+PGY +E ++ C WT P
Sbjct: 413 PPNILNGQ--------KEDRHMVRFDPGTSIKYSCNPGYVLVGEE--SIQCTSEGVWTPP 462
Query: 357 YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGD 412
C+ C QH+ RP +++ SC E + S CQG
Sbjct: 463 VPQCKVAACEATGRQLLTKPQHQFVRP----------DVNSSCGEGYKLSGSVYQECQGT 512
Query: 413 GTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF-FKEEIIYECDKG------YILVGQA 464
W C +I C PP I +G + SS F + + Y C+ G + L+G++
Sbjct: 513 IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572
Query: 465 KLSCSYSH-----WSAPAPQCK-----ALCRKPELVNG-RLSVDKDQYVEPENVTIQCDS 513
+ C+ + WS PAP CK C + NG ++S + Y + VT +C S
Sbjct: 573 TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYS 632
Query: 514 GYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCE 547
G+ + G I C + TW PE+P CE +GC+
Sbjct: 633 GFTLKGSSQIRCKADNTWDPEIPVCE----KGCQ 662
Score = 234 bits (597), Expect = 2e-61
Identities = 162/534 (30%), Positives = 240/534 (44%), Gaps = 58/534 (10%)
Query: 44 PAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV 103
P C PP + D + RF GT++KY+C PGYV +++ C S+G W
Sbjct: 404 PVCEKECQAPPNILNGQKEDRHMV--RFDPGTSIKYSCNPGYVLV-GEESIQCTSEGVWT 460
Query: 104 YNT-FCIYKRCRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGV 161
C C G Q+ K F + SC EG+ L GS C+ +
Sbjct: 461 PPVPQCKVAACEATGR----QLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGT---I 513
Query: 162 GWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDP------RFSLLGHAS 214
W + C+ + C PPP I NG H+G + YG +VTY+C+P FSL+G ++
Sbjct: 514 PWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST 573
Query: 215 ISCTVENETIGVWRPSPPTCE----KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKG 270
I CT ++ G W P C+ + C +++G +SG Y Y DT+ FKC G
Sbjct: 574 IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSG 633
Query: 271 FVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDV--YVVGTVL 328
F L+GSS I C AD+ W+P P CE C + P + H R T + +V G +
Sbjct: 634 FTLKGSSQIRCKADNTWDPEIPVCE-KGCQSPPGLHHG------RHTGGNTVFFVSGMTV 686
Query: 329 RYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCCPEPKLNNGEITQHRKSRPANHC 387
Y C PGY ++ ++ C + W+P CE C + Q + PA
Sbjct: 687 DYTCDPGYLLVGNK--SIHCMPSGNWSPSAPRCEETC--------QHVRQSLQELPAGSR 736
Query: 388 VYFYGDEISFSCHETSRFSAICQG--DGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYS 444
V T +CQ +G W + P C I C+ PP I +G + + +
Sbjct: 737 VELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN 796
Query: 445 F-FKEEIIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCK-----ALCRKPELVNG- 492
F + E+ YECD+G+ L+G+ KL C + WS P+PQC C PE+ +G
Sbjct: 797 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGY 856
Query: 493 RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGC 546
+L+ Y + V + C+ G+ + G + I C + TW P VP C + GC
Sbjct: 857 KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 910
Score = 172 bits (437), Expect = 6e-43
Identities = 159/546 (29%), Positives = 224/546 (41%), Gaps = 78/546 (14%)
Query: 39 IAALLPAVLG-NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97
+A + P VLG +CG PP + I+ T GT ++Y+C G R ++L C
Sbjct: 11 LALVAPGVLGISCGSPPPILNGR---ISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCI 66
Query: 98 S----DGEW-----VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIG 148
+ DG W F Y C P ++ T G + F+C F + G
Sbjct: 67 TKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNG 126
Query: 149 STTSRCEVQDRGVGWSHP-LPQCEIV---KCKPPPDIRNGRHSGEE-NFYAYGFSVTYSC 203
+ + C+ + W LP C V +C P I NG H+ E A G SVTYSC
Sbjct: 127 NKSVWCQANNM---WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSC 183
Query: 204 DPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSG---FGPIYNYK 260
+ + L+G I+C + G W PPTCE+ C+ S G +G PI
Sbjct: 184 ESGYLLVGEKIINCL----SSGKWSAVPPTCEEARCK----SLGRFPNGKVKEPPILRVG 235
Query: 261 DTIVFKCQKGFVLRGSSVIHCDADSK---WNPSPPACEPNSCINLPDIPHASWETYPRPT 317
T F C +G+ L+G C + W P CE C + P I + R
Sbjct: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG------RHI 288
Query: 318 KEDVYVV--GTVLRYRCHPGYKPTTD-----EPT---TVICQKNLRWT-PYQGCE----A 362
+ V G+++ Y C P + + E T TV QK W+ P CE A
Sbjct: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
Query: 363 LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPR 418
+ CP P++ G + +K R Y Y D + F+C C GTW P
Sbjct: 349 VQCPHPQILRGRMVSGQKDR------YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPS 402
Query: 419 TPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYILVGQAKLSC-SYSHWSAP 476
P C C PP I +G + F I Y C+ GY+LVG+ + C S W+ P
Sbjct: 403 APVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP 462
Query: 477 APQCK-ALCRKPELVNGR--LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYP 533
PQCK A C GR L+ + Q+V P+ V C GY + G C G W+
Sbjct: 463 VPQCKVAACE----ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLSGSVYQECQGTIPWFM 517
Query: 534 EVPKCE 539
E+ C+
Sbjct: 518 EIRLCK 523
Score = 171 bits (432), Expect = 2e-42
Identities = 144/529 (27%), Positives = 228/529 (43%), Gaps = 68/529 (12%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHS-----TQTLTCNSD----G 100
C PPP + A +L + F GTT+ YTC PG R T+ C S+ G
Sbjct: 527 CPPPPVIYNGAHTGSSLED--FPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERG 584
Query: 101 EW-----VYNTFCIYKRCRHPGELRNGQVEIK-TDLSFGSQIEFSCSEGFFLIGSTTSRC 154
W + + +C H ++ K + + F C GF L GS+ RC
Sbjct: 585 TWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRC 644
Query: 155 EVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEEN-FYAYGFSVTYSCDPRFSLLGHA 213
+ + W +P CE C+ PP + +GRH+G F+ G +V Y+CDP + L+G+
Sbjct: 645 KADNT---WDPEIPVCE-KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNK 700
Query: 214 SISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL 273
SI C G W PS P CE+ TC+ S E+ +G + + + CQ G+ L
Sbjct: 701 SIHCMPS----GNWSPSAPRCEE-TCQHVRQSLQELPAG-----SRVELVNTSCQDGYQL 750
Query: 274 RGSSVIHC-DADSK-WNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYR 331
G + C DA++ W P C+ C P I + + ++ G + Y
Sbjct: 751 TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM----MAENFLYGNEVSYE 806
Query: 332 CHPGYKPTTDEPTTVICQKNLR----WT-PYQGC----EALCCPEPKLNNGEITQHRKSR 382
C G+ ++ C+ + + W+ P C CP P++ +G ++ ++
Sbjct: 807 CDQGFYLLGEKKLQ--CRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHG----YKLNK 860
Query: 383 PANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPRTPSCGDI----CNFPPKIAH 434
H Y + D + C+ + C D TW P P+C C PPK +
Sbjct: 861 --THSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 918
Query: 435 GHYKQSSSYSFFKE-EIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVN 491
G++ + F I+Y CD+GY+LVG+A L C++ WS PAP CK + C P ++
Sbjct: 919 GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMD 978
Query: 492 G--RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
G + + Y VT++C+ GY + G C + W P + C
Sbjct: 979 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVC 1027
Score = 168 bits (425), Expect = 1e-41
Identities = 139/507 (27%), Positives = 216/507 (42%), Gaps = 61/507 (12%)
Query: 113 CRHPGELRNGQVEI-KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQC 170
C P + NG++ T ++ G+ I +SCS F LIG + C +D+ G W P P+C
Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
Query: 171 EI---VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227
E P P + G Y +G SVT++C FS+ G+ S+ C N +W
Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN----MW 138
Query: 228 RPSP-PTCEKI---TCRKPDVSH-----GEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
P+ PTC + C + H E V P ++ + C+ G++L G +
Sbjct: 139 GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGL----SVTYSCESGYLLVGEKI 194
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYK- 337
I+C + KW+ PP CE C +L P+ + P + VG + C GY+
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPP------ILRVGVTANFFCDEGYRL 248
Query: 338 PTTDEPTTVICQKNLRWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEIS 396
VI + + WT CE + CP P + NG +H + AN YG ++
Sbjct: 249 QGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNG---RHIGNSLAN---VSYGSIVT 302
Query: 397 FSC--------------HETSRFSAICQGDGTWSPRTPSC---GDICNFP-PKIAHGHY- 437
++C T R + Q GTWS P C P P+I G
Sbjct: 303 YTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV 362
Query: 438 -KQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKALCR-KPELVNGRL 494
Q Y+ + + +I+ C G+ L G ++ C + W AP C+ C+ P ++NG+
Sbjct: 363 SGQKDRYT-YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQK 421
Query: 495 SVDKDQYVEP-ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGK 553
+P ++ C+ GY +VG +SI C+ W P VP+C+ E + L K
Sbjct: 422 EDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK 481
Query: 554 RLMQCLPNPEDVKMALEVYKLSLEIEQ 580
Q + P+ E YKLS + Q
Sbjct: 482 PQHQFV-RPDVNSSCGEGYKLSGSVYQ 507
Score = 151 bits (381), Expect = 2e-36
Identities = 115/413 (27%), Positives = 180/413 (43%), Gaps = 43/413 (10%)
Query: 173 VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPP 232
+ C PP I NGR S A G + YSC F L+G S+ C +++ G W P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 233 TCEKI----TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWN 288
CE +C +P V G + G P Y + D++ F C+ F + G+ + C A++ W
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
Query: 289 PSP-PACE---PNSCINLPDIPHASWETYPRPTKEDVYVV--GTVLRYRCHPGYKPTTDE 342
P+ P C P C LP I + T E+V + G + Y C GY ++
Sbjct: 140 PTRLPTCVSVFPLECPALPMIHNG------HHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
Query: 343 PTTVICQKNLRWT--PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
+ C + +W+ P EA C + NG++ + R +F +
Sbjct: 194 --IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
Query: 401 ETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHG-HYKQSSSYSFFKEEIIYECDK-- 456
+SR + G G + P C +I C PP I +G H S + + + Y CD
Sbjct: 252 PSSR--CVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
Query: 457 ----GYILVGQAKLSCSYSH-----WSAPAPQCK-----ALCRKPELVNGRL-SVDKDQY 501
+IL+G++ L C+ WS PAP+C+ C P+++ GR+ S KD+Y
Sbjct: 310 EEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRY 369
Query: 502 VEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKR 554
+ V C G+ + G + I C+ TW P P CE E + +L G++
Sbjct: 370 TYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC-QAPPNILNGQK 421
Score = 107 bits (266), Expect = 4e-23
Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 29/267 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSD----GEWVY 104
+C PPP + + F G + Y C G+ + L C SD G W
Sbjct: 777 HCHPPPVI--VNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEKKLQCRSDSKGHGSWSG 833
Query: 105 -NTFCIYK----RCRHPGELRNGQVEIKTDLSFGSQ--IEFSCSEGFFLIGSTTSRCEVQ 157
+ C+ RC +P E+++G KT ++ + C+ GF + GS RC
Sbjct: 834 PSPQCLRSPPVTRCPNP-EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTD 892
Query: 158 DRGVGWSHPLPQC---EIVKCKPPPDIRNGRHSGEENF-YAYGFSVTYSCDPRFSLLGHA 213
+ W +P C + C PPP NG H+G ++ G S+ YSCD + L+G A
Sbjct: 893 NT---WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 949
Query: 214 SISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP--IYNYKDTIVFKCQKGF 271
+ CT E G W P C+++ C P G + G P +Y Y + +C+ G+
Sbjct: 950 LLLCTHE----GTWSQPAPHCKEVNCSSPADMDG-IQKGLEPRKMYQYGAVVTLECEDGY 1004
Query: 272 VLRGSSVIHCDADSKWNPSPPACEPNS 298
+L GS C +D +WNP C S
Sbjct: 1005 MLEGSPQSQCQSDHQWNPPLAVCRSRS 1031
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/135 (26%), Positives = 54/135 (40%), Gaps = 11/135 (8%)
Query: 423 GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPA 477
G C PP I +G S+ I Y C + L+G+ L C W PA
Sbjct: 20 GISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPA 79
Query: 478 PQCK-----ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
P+C+ + C +P + G Y ++VT C + + + G +S+ C N W
Sbjct: 80 PKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
Query: 533 P-EVPKCEWETPEGC 546
P +P C P C
Sbjct: 140 PTRLPTCVSVFPLEC 154
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 228 bits (580), Expect = 2e-59
Identities = 172/587 (29%), Positives = 241/587 (41%), Gaps = 103/587 (17%)
Query: 48 GNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNT 106
G+C P FA+P I + + F GT+L Y C PGY + ++C + W
Sbjct: 1844 GHCKTPEQFPFASPT-IPINDFEFPVGTSLNYECRPGYFGKMFS--ISCLENLVWSSVED 1900
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
C K C P E NG V I TD FGS + +SC+EGF LIGS ++ C V V W
Sbjct: 1901 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1960
Query: 167 LPQCEIVKCKPPPDIRNGR-HSGEENFYAYGFSVTYSC------DPRFSLLGHASISCTV 219
P CEI+ C+PPP I NG +S + G VTY C + F L+G SI CT
Sbjct: 1961 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 2020
Query: 220 ENETIGVWRPSPPTCEKIT-CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
+++ +GVW PP C C P+V + V G + + I F+CQ GFV+ GS
Sbjct: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKP 338
+ C + +W P P C C P+I H + +D + G + Y C P Y
Sbjct: 2081 VQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTL----SHQDNFSPGQEVFYSCEPSY-- 2133
Query: 339 TTDEPTTVICQKNLRWTP-YQGCEALCCPE--PKLNNGEITQ------------------ 377
++ C W+P C C + +L +G +
Sbjct: 2134 DLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGF 2193
Query: 378 HRKSRPANHCVYF--------------------------------------YGDEISFSC 399
K R A+HCV YG EIS++C
Sbjct: 2194 RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYAC 2253
Query: 400 --------------HETSRFSAICQGDGTWSPRTPSC----GDICNFPPKIAHGHYKQSS 441
+ R ++ QG+G WS P C C PPKI +GHY
Sbjct: 2254 DTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGH 2313
Query: 442 SYSFFK-EEIIYECDKGYILVGQAKLSCS-YSHWSAPAPQCKAL-CRKPELVNGRLSVD- 497
+ I Y CD GY+LVG+ + C+ WS CK + C P +NG +S +
Sbjct: 2314 VSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNG-ISKEL 2372
Query: 498 --KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWET 542
K Y + VT++C+ GY + G C + W P + KC T
Sbjct: 2373 EMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRT 2419
Score = 221 bits (562), Expect = 2e-57
Identities = 158/537 (29%), Positives = 244/537 (45%), Gaps = 52/537 (9%)
Query: 38 LIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97
++ LP G C P L FA P ++T E F GT L Y C PGY S ++ C
Sbjct: 31 VVLLALPVAWGQCNAPEWLPFARPTNLT-DEFEFPIGTYLNYECRPGY--SGRPFSIICL 87
Query: 98 SDGEWV-YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEV 156
+ W C K CR+P + NG V + + FGSQI++SC++G+ LIGS+++ C +
Sbjct: 88 KNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII 147
Query: 157 QDRGVGWSHPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FS 208
V W + P C+ + C PP I NG + ENF+ YG VTY C+P F
Sbjct: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFE 206
Query: 209 LLGHASISCTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267
L+G SI CT ++ +G+W P+P C P+V +G +VS +++ + + F+C
Sbjct: 207 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 266
Query: 268 QKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTV 327
Q GFV++G + C A +KW P P+C C PD+ HA +D + G
Sbjct: 267 QPGFVMKGPRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQE 321
Query: 328 LRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANH 386
+ Y C PGY ++ C W+P CE C + G++ R P N
Sbjct: 322 VFYSCEPGY--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN- 375
Query: 387 CVYFYGDEISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYK 438
G ++ F C E ++ + + + W+ P C I C PP I +G +
Sbjct: 376 --LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 433
Query: 439 QSSSYSF-FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--C 484
F F + + Y CD + L+G++ + C+ WS+PAP+C L C
Sbjct: 434 GKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493
Query: 485 RKPE-LVNGRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539
+ P+ + +L + P +++ + G P SITC N W C+
Sbjct: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 550
Score = 202 bits (514), Expect = 7e-52
Identities = 151/529 (28%), Positives = 235/529 (44%), Gaps = 52/529 (9%)
Query: 46 VLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVY- 104
+LG+C P FA + + F GT+LKY C P Y + +TC + W
Sbjct: 489 ILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS--ITCLDNLVWSSP 545
Query: 105 NTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWS 164
C K C+ P + NG V + TD+ GS+I +SC+ G LIG +++ C + WS
Sbjct: 546 KDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 605
Query: 165 HPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FSLLGHASIS 216
P C+ + C PP I NG + ENF+ YG VTY C+P F L+G SI
Sbjct: 606 TKPPICQRIPCGLPPTIANGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFELVGEPSIY 664
Query: 217 CTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275
CT ++ +G+W P+P C P+V +G +VS +++ + + F+CQ GFV++G
Sbjct: 665 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 724
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
+ C A +KW P P+C C PD+ HA +D + G + Y C PG
Sbjct: 725 PRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQEVFYSCEPG 779
Query: 336 YKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDE 394
Y ++ C W+P CE C + G++ R P N G +
Sbjct: 780 Y--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN---LQLGAK 831
Query: 395 ISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF- 445
+ F C E ++ + + + W+ P C I C PP I +G + F
Sbjct: 832 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 891
Query: 446 FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--CRKPE-LVN 491
F + + Y CD + L+G++ + C+ WS+PAP+C L C+ P+ +
Sbjct: 892 FGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 951
Query: 492 GRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539
+L + P +++ + G P SITC N W C+
Sbjct: 952 AKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 1000
Score = 181 bits (459), Expect = 2e-45
Identities = 142/551 (25%), Positives = 232/551 (42%), Gaps = 68/551 (12%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102
LP+ C PPP + + F G + Y+C PGY +L C G+W
Sbjct: 1640 LPSCSRVCQPPPEILHGE--HTPSHQDNFSPGQEVFYSCEPGY-DLRGAASLHCTPQGDW 1696
Query: 103 VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C K C G+L +G+V +L G+++ F C EGF L GS+ S C +
Sbjct: 1697 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMR 1756
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSG-EENFYAYGFSVTYSCDPR------FSLLGHA 213
W++ +P CE + C PP I NGRH+G YG ++Y+CDP F+L+G +
Sbjct: 1757 SLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES 1816
Query: 214 SISCTVENETIGVWRPSPPTCEKIT----CRKPDVSHGEMVSGFGPIYNYK----DTIVF 265
+I CT + GVW P CE C+ P+ S PI +++ ++ +
Sbjct: 1817 TIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE--QFPFASPTIPINDFEFPVGTSLNY 1874
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPD----IPHASWETYPRPTKEDV 321
+C+ G+ + S I C + W+ C SC P+ + H + +T
Sbjct: 1875 ECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ-------- 1925
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTT-VICQKNLRWTPYQG-CEALCC-PEPKLNNGEITQH 378
G+ + Y C+ G++ TT ++ N+ W CE + C P P ++NG+ +
Sbjct: 1926 --FGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSN 1983
Query: 379 RKSRPANHCVYFYGDEISFSCHE----------TSRFSAICQGD----GTWSPRTPSC-- 422
N + G +++ CH S C G WS P C
Sbjct: 1984 ------NRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 2037
Query: 423 GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCK 481
+ C P + S+ E I + C G+++VG + C + W P C
Sbjct: 2038 TNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS 2097
Query: 482 ALCR-KPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
+C+ PE+++G ++ +D + + V C+ Y + G S+ C+ W PE P+C
Sbjct: 2098 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC- 2156
Query: 540 WETPEGCEQVL 550
T + C+ L
Sbjct: 2157 --TVKSCDDFL 2165
Score = 178 bits (451), Expect = 1e-44
Identities = 151/559 (27%), Positives = 241/559 (43%), Gaps = 73/559 (13%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102
LP+ C PPP + A + F G + Y+C PGY ++ C G+W
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQ--RDKDNFSPGQEVFYSCEPGY-DLRGAASMRCTPQGDW 796
Query: 103 VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C K C G+L NG+V +L G++++F C EGF L GS+ S C +
Sbjct: 797 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 856
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGHA 213
W+ +P CE + C PP I NGRH+G+ + +G +V Y+CDP F L+G +
Sbjct: 857 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 916
Query: 214 SISCTVENETIGVWRPSPPTCEKI-TCRKPD------VSHGEMVSGFGPIYNYKDTIVFK 266
+I CT + + GVW P C + C+ PD + S F PI ++ ++
Sbjct: 917 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF-PI---GTSLKYE 972
Query: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV--- 323
C+ + R S I C + W+ C+ SC +T P P V+V
Sbjct: 973 CRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSC-----------KTPPDPVNGMVHVITD 1020
Query: 324 --VGTVLRYRCHPGYKPTTDEPTTVICQKN-LRW-TPYQGCEALCCP-EPKLNNGE-ITQ 377
VG+ + Y C G++ I N W T C+ + C P + NG+ I+
Sbjct: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 1080
Query: 378 HRKSRPANHCVYFYGDEISFSCHETS----------RFSAICQGD----GTWSPRTPSC- 422
+R++ + YG +++ C+ S S C + G WS P C
Sbjct: 1081 NREN-------FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
Query: 423 -GDICNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC-SYSHWSAPAPQ 479
+ C PP + +G + F E++ + C G+++ G ++ C + + W P
Sbjct: 1134 IPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1192
Query: 480 CKALCRKPE--LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537
C +C+ P L R DKD + + V C+ GY + G S+ C+ W P P
Sbjct: 1193 CSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 1252
Query: 538 CEWET-PEGCEQVLTGKRL 555
CE ++ + Q+L G+ L
Sbjct: 1253 CEVKSCDDFMGQLLNGRVL 1271
Score = 178 bits (451), Expect = 1e-44
Identities = 146/541 (26%), Positives = 237/541 (43%), Gaps = 72/541 (13%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102
LP+ C PPP + A + F G + Y+C PGY ++ C G+W
Sbjct: 1190 LPSCSRVCQPPPDVLHAERTQ--RDKDNFSPGQEVFYSCEPGY-DLRGAASMRCTPQGDW 1246
Query: 103 VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C K C G+L NG+V +L G++++F C EGF L GS+ S C +
Sbjct: 1247 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 1306
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGHA 213
W+ +P CE + C PP I NGRH+G+ + +G +V Y+CDP F L+G +
Sbjct: 1307 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGES 1366
Query: 214 SISCTVENETIGVWRPSPPTCEKI-TCRKPD------VSHGEMVSGFGPIYNYKDTIVFK 266
+I CT + + GVW P C + C+ PD + S F PI ++ ++
Sbjct: 1367 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF-PI---GTSLKYE 1422
Query: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV--- 323
C+ + R S I C + W+ C+ SC +T P P V+V
Sbjct: 1423 CRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSC-----------KTPPDPVNGMVHVITD 1470
Query: 324 --VGTVLRYRCHPGYKPTTDEPTTVICQKN-LRW-TPYQGCEALCCP-EPKLNNGE-ITQ 377
VG+ + Y C G++ I N W T C+ + C P + NG+ I+
Sbjct: 1471 IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST 1530
Query: 378 HRKSRPANHCVYFYGDEISFSCHETSRF----------SAICQGD----GTWSPRTPSC- 422
+R++ + YG +++ C+ SR S C + G WS P C
Sbjct: 1531 NREN-------FHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1583
Query: 423 -GDICNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC-SYSHWSAPAPQ 479
+ C PP + +G + F E++ + C G+++ G ++ C + + W P
Sbjct: 1584 IPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1642
Query: 480 CKALCR-KPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537
C +C+ PE+++G + +D + + V C+ GY + G S+ C+ W PE P+
Sbjct: 1643 CSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPR 1702
Query: 538 C 538
C
Sbjct: 1703 C 1703
Score = 151 bits (381), Expect = 2e-36
Identities = 131/521 (25%), Positives = 209/521 (40%), Gaps = 74/521 (14%)
Query: 69 TRFKTGTTLKYTCLPGY--VRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQV- 124
T + G+ + Y+C G+ + S + + + W C C P + NG
Sbjct: 1469 TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI 1528
Query: 125 -EIKTDLSFGSQIEFSCSEG------FFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCK 176
+ + +GS + + C+ G F L+G + C D VG WS P PQC I
Sbjct: 1529 STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 1588
Query: 177 PPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
PP++ NG S + ++ V + C P F + G + C N+ W P P+C
Sbjct: 1589 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSCS 1644
Query: 236 KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACE 295
++ P++ HGE ++ + + C+ G+ LRG++ +HC W+P P C
Sbjct: 1645 RVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1704
Query: 296 PNSCIN-LPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY--KPTTDEPTTVICQKNL 352
SC + L +PH +P + +G + + C G+ K ++ ++ ++L
Sbjct: 1705 VKSCDDFLGQLPHGR-VLFPLNLQ-----LGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1758
Query: 353 RWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEISFSC------------ 399
CE + CP P + NG T P+ YG EIS++C
Sbjct: 1759 WNNSVPVCEHIFCPNPPAILNGRHT----GTPSGDIP--YGKEISYTCDPHPDRGMTFNL 1812
Query: 400 --HETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI------- 450
T R ++ G+G WS P C + GH K + F I
Sbjct: 1813 IGESTIRCTSDPHGNGVWSSPAPRC------ELSVRAGHCKTPEQFPFASPTIPINDFEF 1866
Query: 451 ------IYECDKGYILVGQAKLSCSYS-HWSAPAPQC--KALCRKPELVNGRLSVDKDQY 501
YEC GY +SC + WS+ C K+ PE NG + ++ D
Sbjct: 1867 PVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1925
Query: 502 VEPENVTIQCDSGYGVVGPQSITC--SGNR-TWYPEVPKCE 539
V C+ G+ ++G S TC SGN TW + P CE
Sbjct: 1926 F-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965
Score = 150 bits (378), Expect = 4e-36
Identities = 134/526 (25%), Positives = 212/526 (40%), Gaps = 73/526 (13%)
Query: 74 GTTLKYTCLPGYVRSHS-----TQTLTCNSD--GEWVYNT---FCIYK----RCRHPGEL 119
G + YTC P R + T+ C SD G V+++ C C+ P +
Sbjct: 1793 GKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF 1852
Query: 120 RNGQVEIK-TDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCK 176
I D F G+ + + C G+F + S E + WS C C
Sbjct: 1853 PFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLE----NLVWSSVEDNCRRKSCG 1908
Query: 177 PPPDIRNGR-HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
PPP+ NG H + +G +V YSC+ F L+G S +C V + W P CE
Sbjct: 1909 PPPEPFNGMVHINTDT--QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNV-TWDKKAPICE 1965
Query: 236 KITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKG------FVLRGSSVIHC----DAD 284
I+C P +S+G+ S ++ + ++C G F L G I+C D
Sbjct: 1966 IISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 2025
Query: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
W+ PP C + P++ +A P + + ++R+RC PG+
Sbjct: 2026 GVWSSPPPRCISTNKCTAPEVENA----IRVPGNRSFFTLTEIIRFRCQPGFVMVGSH-- 2079
Query: 345 TVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHET- 402
TV CQ N RW P C +C P P++ +GE H S N + G E+ +SC +
Sbjct: 2080 TVQCQTNGRWGPKLPHCSRVCQPPPEILHGE---HTLSHQDN---FSPGQEVFYSCEPSY 2133
Query: 403 ---SRFSAICQGDGTWSPRTPSCG--DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457
S C G WSP P C +F ++ HG + ++ + CD+G
Sbjct: 2134 DLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQL-GAKVSFVCDEG 2192
Query: 458 YILVGQAKLSCSYSH----WSAPAPQCKALC--RKPELVNGR-LSVDKDQYVEPENVTIQ 510
+ L G++ C + W++ P C+ + P ++NGR + ++
Sbjct: 2193 FRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYA 2252
Query: 511 CDSG------YGVVGPQSITCS----GNRTWYPEVPKCEWETPEGC 546
CD+ + ++G SI C+ GN W P+CE P C
Sbjct: 2253 CDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAAC 2298
Score = 134 bits (337), Expect = 2e-31
Identities = 96/328 (29%), Positives = 141/328 (42%), Gaps = 24/328 (7%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLT-ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE 101
LP C PPP + + TL+ + F G + Y+C P Y +L C G+
Sbjct: 2093 LPHCSRVCQPPPEILHG---EHTLSHQDNFSPGQEVFYSCEPSY-DLRGAASLHCTPQGD 2148
Query: 102 WVYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDR 159
W C K C G+L +G+V + +L G+++ F C EGF L G + S C +
Sbjct: 2149 WSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 2208
Query: 160 GVGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGH 212
W+ +P CE + C PP I NGRH+G YG ++Y+CD F+L+G
Sbjct: 2209 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 2268
Query: 213 ASISCTVENETIGVWRPSPPTCE---KITC-RKPDVSHGEMVSGFGPIYNYKDTIVFKCQ 268
+SI CT + + GVW P CE C P + +G + G +Y TI + C
Sbjct: 2269 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 2328
Query: 269 KGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVL 328
G++L G I C W+ C+ +C P + VY G +
Sbjct: 2329 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC----SFPLFMNGISKELEMKKVYHYGDYV 2384
Query: 329 RYRCHPGYKPTTDEPTTVICQKNLRWTP 356
+C GY T + CQ + RW P
Sbjct: 2385 TLKCEDGY--TLEGSPWSQCQADDRWDP 2410
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 228 bits (580), Expect = 2e-59
Identities = 172/587 (29%), Positives = 241/587 (41%), Gaps = 103/587 (17%)
Query: 48 GNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNT 106
G+C P FA+P I + + F GT+L Y C PGY + ++C + W
Sbjct: 1394 GHCKTPEQFPFASPT-IPINDFEFPVGTSLNYECRPGYFGKMFS--ISCLENLVWSSVED 1450
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
C K C P E NG V I TD FGS + +SC+EGF LIGS ++ C V V W
Sbjct: 1451 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1510
Query: 167 LPQCEIVKCKPPPDIRNGR-HSGEENFYAYGFSVTYSC------DPRFSLLGHASISCTV 219
P CEI+ C+PPP I NG +S + G VTY C + F L+G SI CT
Sbjct: 1511 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 1570
Query: 220 ENETIGVWRPSPPTCEKIT-CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
+++ +GVW PP C C P+V + V G + + I F+CQ GFV+ GS
Sbjct: 1571 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 1630
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKP 338
+ C + +W P P C C P+I H + +D + G + Y C P Y
Sbjct: 1631 VQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTL----SHQDNFSPGQEVFYSCEPSY-- 1683
Query: 339 TTDEPTTVICQKNLRWTP-YQGCEALCCPE--PKLNNGEITQ------------------ 377
++ C W+P C C + +L +G +
Sbjct: 1684 DLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGF 1743
Query: 378 HRKSRPANHCVYF--------------------------------------YGDEISFSC 399
K R A+HCV YG EIS++C
Sbjct: 1744 RLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYAC 1803
Query: 400 --------------HETSRFSAICQGDGTWSPRTPSC----GDICNFPPKIAHGHYKQSS 441
+ R ++ QG+G WS P C C PPKI +GHY
Sbjct: 1804 DTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGH 1863
Query: 442 SYSFFK-EEIIYECDKGYILVGQAKLSCS-YSHWSAPAPQCKAL-CRKPELVNGRLSVD- 497
+ I Y CD GY+LVG+ + C+ WS CK + C P +NG +S +
Sbjct: 1864 VSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNG-ISKEL 1922
Query: 498 --KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWET 542
K Y + VT++C+ GY + G C + W P + KC T
Sbjct: 1923 EMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRT 1969
Score = 221 bits (562), Expect = 2e-57
Identities = 158/537 (29%), Positives = 244/537 (45%), Gaps = 52/537 (9%)
Query: 38 LIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97
++ LP G C P L FA P ++T E F GT L Y C PGY S ++ C
Sbjct: 31 VVLLALPVAWGQCNAPEWLPFARPTNLT-DEFEFPIGTYLNYECRPGY--SGRPFSIICL 87
Query: 98 SDGEWV-YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEV 156
+ W C K CR+P + NG V + + FGSQI++SC++G+ LIGS+++ C +
Sbjct: 88 KNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII 147
Query: 157 QDRGVGWSHPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FS 208
V W + P C+ + C PP I NG + ENF+ YG VTY C+P F
Sbjct: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFE 206
Query: 209 LLGHASISCTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267
L+G SI CT ++ +G+W P+P C P+V +G +VS +++ + + F+C
Sbjct: 207 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 266
Query: 268 QKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTV 327
Q GFV++G + C A +KW P P+C C PD+ HA +D + G
Sbjct: 267 QPGFVMKGPRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQE 321
Query: 328 LRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANH 386
+ Y C PGY ++ C W+P CE C + G++ R P N
Sbjct: 322 VFYSCEPGY--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN- 375
Query: 387 CVYFYGDEISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYK 438
G ++ F C E ++ + + + W+ P C I C PP I +G +
Sbjct: 376 --LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 433
Query: 439 QSSSYSF-FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--C 484
F F + + Y CD + L+G++ + C+ WS+PAP+C L C
Sbjct: 434 GKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493
Query: 485 RKPE-LVNGRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539
+ P+ + +L + P +++ + G P SITC N W C+
Sbjct: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 550
Score = 202 bits (514), Expect = 7e-52
Identities = 151/529 (28%), Positives = 235/529 (44%), Gaps = 52/529 (9%)
Query: 46 VLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVY- 104
+LG+C P FA + + F GT+LKY C P Y + +TC + W
Sbjct: 489 ILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS--ITCLDNLVWSSP 545
Query: 105 NTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWS 164
C K C+ P + NG V + TD+ GS+I +SC+ G LIG +++ C + WS
Sbjct: 546 KDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 605
Query: 165 HPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTYSCDPR------FSLLGHASIS 216
P C+ + C PP I NG + ENF+ YG VTY C+P F L+G SI
Sbjct: 606 TKPPICQRIPCGLPPTIANGDFISTNRENFH-YGSVVTYRCNPGSGGRKVFELVGEPSIY 664
Query: 217 CTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275
CT ++ +G+W P+P C P+V +G +VS +++ + + F+CQ GFV++G
Sbjct: 665 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 724
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
+ C A +KW P P+C C PD+ HA +D + G + Y C PG
Sbjct: 725 PRRVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQEVFYSCEPG 779
Query: 336 YKPTTDEPTTVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDE 394
Y ++ C W+P CE C + G++ R P N G +
Sbjct: 780 Y--DLRGAASMRCTPQGDWSPAAPTCEVKSCDD---FMGQLLNGRVLFPVN---LQLGAK 831
Query: 395 ISFSCHE-------TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF- 445
+ F C E ++ + + + W+ P C I C PP I +G + F
Sbjct: 832 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 891
Query: 446 FKEEIIYECD------KGYILVGQAKLSCSYSH-----WSAPAPQCKAL--CRKPE-LVN 491
F + + Y CD + L+G++ + C+ WS+PAP+C L C+ P+ +
Sbjct: 892 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 951
Query: 492 GRLSVDKDQYVEPENVTIQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539
+L + P +++ + G P SITC N W C+
Sbjct: 952 AKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCK 1000
Score = 181 bits (459), Expect = 2e-45
Identities = 142/551 (25%), Positives = 232/551 (42%), Gaps = 68/551 (12%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102
LP+ C PPP + + F G + Y+C PGY +L C G+W
Sbjct: 1190 LPSCSRVCQPPPEILHGE--HTPSHQDNFSPGQEVFYSCEPGY-DLRGAASLHCTPQGDW 1246
Query: 103 VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C K C G+L +G+V +L G+++ F C EGF L GS+ S C +
Sbjct: 1247 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMR 1306
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSG-EENFYAYGFSVTYSCDPR------FSLLGHA 213
W++ +P CE + C PP I NGRH+G YG ++Y+CDP F+L+G +
Sbjct: 1307 SLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGES 1366
Query: 214 SISCTVENETIGVWRPSPPTCEKIT----CRKPDVSHGEMVSGFGPIYNYK----DTIVF 265
+I CT + GVW P CE C+ P+ S PI +++ ++ +
Sbjct: 1367 TIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE--QFPFASPTIPINDFEFPVGTSLNY 1424
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPD----IPHASWETYPRPTKEDV 321
+C+ G+ + S I C + W+ C SC P+ + H + +T
Sbjct: 1425 ECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ-------- 1475
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTT-VICQKNLRWTPYQG-CEALCC-PEPKLNNGEITQH 378
G+ + Y C+ G++ TT ++ N+ W CE + C P P ++NG+ +
Sbjct: 1476 --FGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSN 1533
Query: 379 RKSRPANHCVYFYGDEISFSCHE----------TSRFSAICQGD----GTWSPRTPSC-- 422
N + G +++ CH S C G WS P C
Sbjct: 1534 ------NRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 1587
Query: 423 GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCK 481
+ C P + S+ E I + C G+++VG + C + W P C
Sbjct: 1588 TNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS 1647
Query: 482 ALCR-KPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
+C+ PE+++G ++ +D + + V C+ Y + G S+ C+ W PE P+C
Sbjct: 1648 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC- 1706
Query: 540 WETPEGCEQVL 550
T + C+ L
Sbjct: 1707 --TVKSCDDFL 1715
Score = 178 bits (451), Expect = 1e-44
Identities = 146/541 (26%), Positives = 237/541 (43%), Gaps = 72/541 (13%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW 102
LP+ C PPP + A + F G + Y+C PGY ++ C G+W
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQ--RDKDNFSPGQEVFYSCEPGY-DLRGAASMRCTPQGDW 796
Query: 103 VYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C K C G+L NG+V +L G++++F C EGF L GS+ S C +
Sbjct: 797 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 856
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGHA 213
W+ +P CE + C PP I NGRH+G+ + +G +V Y+CDP F L+G +
Sbjct: 857 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGES 916
Query: 214 SISCTVENETIGVWRPSPPTCEKI-TCRKPD------VSHGEMVSGFGPIYNYKDTIVFK 266
+I CT + + GVW P C + C+ PD + S F PI ++ ++
Sbjct: 917 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF-PI---GTSLKYE 972
Query: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV--- 323
C+ + R S I C + W+ C+ SC +T P P V+V
Sbjct: 973 CRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSC-----------KTPPDPVNGMVHVITD 1020
Query: 324 --VGTVLRYRCHPGYKPTTDEPTTVICQKN-LRW-TPYQGCEALCCP-EPKLNNGE-ITQ 377
VG+ + Y C G++ I N W T C+ + C P + NG+ I+
Sbjct: 1021 IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST 1080
Query: 378 HRKSRPANHCVYFYGDEISFSCHETSRF----------SAICQGD----GTWSPRTPSC- 422
+R++ + YG +++ C+ SR S C + G WS P C
Sbjct: 1081 NREN-------FHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
Query: 423 -GDICNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC-SYSHWSAPAPQ 479
+ C PP + +G + F E++ + C G+++ G ++ C + + W P
Sbjct: 1134 IPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPS 1192
Query: 480 CKALCR-KPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537
C +C+ PE+++G + +D + + V C+ GY + G S+ C+ W PE P+
Sbjct: 1193 CSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPR 1252
Query: 538 C 538
C
Sbjct: 1253 C 1253
Score = 151 bits (381), Expect = 2e-36
Identities = 131/521 (25%), Positives = 209/521 (40%), Gaps = 74/521 (14%)
Query: 69 TRFKTGTTLKYTCLPGY--VRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQV- 124
T + G+ + Y+C G+ + S + + + W C C P + NG
Sbjct: 1019 TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI 1078
Query: 125 -EIKTDLSFGSQIEFSCSEG------FFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCK 176
+ + +GS + + C+ G F L+G + C D VG WS P PQC I
Sbjct: 1079 STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC 1138
Query: 177 PPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
PP++ NG S + ++ V + C P F + G + C N+ W P P+C
Sbjct: 1139 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSCS 1194
Query: 236 KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACE 295
++ P++ HGE ++ + + C+ G+ LRG++ +HC W+P P C
Sbjct: 1195 RVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1254
Query: 296 PNSCIN-LPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY--KPTTDEPTTVICQKNL 352
SC + L +PH +P + +G + + C G+ K ++ ++ ++L
Sbjct: 1255 VKSCDDFLGQLPHGR-VLFPLNLQ-----LGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1308
Query: 353 RWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEISFSC------------ 399
CE + CP P + NG T P+ YG EIS++C
Sbjct: 1309 WNNSVPVCEHIFCPNPPAILNGRHT----GTPSGDIP--YGKEISYTCDPHPDRGMTFNL 1362
Query: 400 --HETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI------- 450
T R ++ G+G WS P C + GH K + F I
Sbjct: 1363 IGESTIRCTSDPHGNGVWSSPAPRC------ELSVRAGHCKTPEQFPFASPTIPINDFEF 1416
Query: 451 ------IYECDKGYILVGQAKLSCSYS-HWSAPAPQC--KALCRKPELVNGRLSVDKDQY 501
YEC GY +SC + WS+ C K+ PE NG + ++ D
Sbjct: 1417 PVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ 1475
Query: 502 VEPENVTIQCDSGYGVVGPQSITC--SGNR-TWYPEVPKCE 539
V C+ G+ ++G S TC SGN TW + P CE
Sbjct: 1476 F-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515
Score = 150 bits (378), Expect = 4e-36
Identities = 134/526 (25%), Positives = 212/526 (40%), Gaps = 73/526 (13%)
Query: 74 GTTLKYTCLPGYVRSHS-----TQTLTCNSD--GEWVYNT---FCIYK----RCRHPGEL 119
G + YTC P R + T+ C SD G V+++ C C+ P +
Sbjct: 1343 GKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF 1402
Query: 120 RNGQVEIK-TDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCK 176
I D F G+ + + C G+F + S E + WS C C
Sbjct: 1403 PFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLE----NLVWSSVEDNCRRKSCG 1458
Query: 177 PPPDIRNGR-HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
PPP+ NG H + +G +V YSC+ F L+G S +C V + W P CE
Sbjct: 1459 PPPEPFNGMVHINTDT--QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNV-TWDKKAPICE 1515
Query: 236 KITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKG------FVLRGSSVIHC----DAD 284
I+C P +S+G+ S ++ + ++C G F L G I+C D
Sbjct: 1516 IISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 1575
Query: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
W+ PP C + P++ +A P + + ++R+RC PG+
Sbjct: 1576 GVWSSPPPRCISTNKCTAPEVENA----IRVPGNRSFFTLTEIIRFRCQPGFVMVGSH-- 1629
Query: 345 TVICQKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHET- 402
TV CQ N RW P C +C P P++ +GE H S N + G E+ +SC +
Sbjct: 1630 TVQCQTNGRWGPKLPHCSRVCQPPPEILHGE---HTLSHQDN---FSPGQEVFYSCEPSY 1683
Query: 403 ---SRFSAICQGDGTWSPRTPSCG--DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457
S C G WSP P C +F ++ HG + ++ + CD+G
Sbjct: 1684 DLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQL-GAKVSFVCDEG 1742
Query: 458 YILVGQAKLSCSYSH----WSAPAPQCKALC--RKPELVNGR-LSVDKDQYVEPENVTIQ 510
+ L G++ C + W++ P C+ + P ++NGR + ++
Sbjct: 1743 FRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYA 1802
Query: 511 CDSG------YGVVGPQSITCS----GNRTWYPEVPKCEWETPEGC 546
CD+ + ++G SI C+ GN W P+CE P C
Sbjct: 1803 CDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAAC 1848
Score = 134 bits (337), Expect = 2e-31
Identities = 96/328 (29%), Positives = 141/328 (42%), Gaps = 24/328 (7%)
Query: 43 LPAVLGNCGPPPTLSFAAPMDITLT-ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE 101
LP C PPP + + TL+ + F G + Y+C P Y +L C G+
Sbjct: 1643 LPHCSRVCQPPPEILHG---EHTLSHQDNFSPGQEVFYSCEPSY-DLRGAASLHCTPQGD 1698
Query: 102 WVYNT-FCIYKRCRH-PGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDR 159
W C K C G+L +G+V + +L G+++ F C EGF L G + S C +
Sbjct: 1699 WSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 1758
Query: 160 GVGWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDPR------FSLLGH 212
W+ +P CE + C PP I NGRH+G YG ++Y+CD F+L+G
Sbjct: 1759 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 1818
Query: 213 ASISCTVENETIGVWRPSPPTCE---KITC-RKPDVSHGEMVSGFGPIYNYKDTIVFKCQ 268
+SI CT + + GVW P CE C P + +G + G +Y TI + C
Sbjct: 1819 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 1878
Query: 269 KGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVL 328
G++L G I C W+ C+ +C P + VY G +
Sbjct: 1879 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC----SFPLFMNGISKELEMKKVYHYGDYV 1934
Query: 329 RYRCHPGYKPTTDEPTTVICQKNLRWTP 356
+C GY T + CQ + RW P
Sbjct: 1935 TLKCEDGY--TLEGSPWSQCQADDRWDP 1960
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 218 bits (554), Expect = 2e-56
Identities = 147/484 (30%), Positives = 222/484 (45%), Gaps = 50/484 (10%)
Query: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTD 129
+ G + ++C GY T+ +TC GEW + +C C P NG +E +
Sbjct: 1805 YTVGAEVTFSCQEGYQLMGVTK-ITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE-ELA 1862
Query: 130 LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH--S 187
+FGS++ + C++G+ L G S C WSH P CE VKC P +I NG++ S
Sbjct: 1863 FTFGSKVTYRCNKGYTLAGDKESSCLANS---SWSHSPPVCEPVKCSSPENINNGKYILS 1919
Query: 188 GEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHG 247
G Y + +YSCD +SL G + I CT G+W +PP C + C +P
Sbjct: 1920 G----LTYLSTASYSCDTGYSLQGPSIIECTAS----GIWDRAPPACHLVFCGEPPAIKD 1971
Query: 248 EMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307
+++G + +++T+ + C++G+ L G I C AD KW+ S C SC P + H
Sbjct: 1972 AVITGNN--FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDH 2029
Query: 308 ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-----CEA 362
AS ET R + G + Y C GY + + + ++C +W P +G C A
Sbjct: 2030 ASPETAHR-------LFGDIAFYYCSDGY--SLADNSQLLCNAQGKWVPPEGQDMPRCIA 2080
Query: 363 LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPR 418
C +P + I + + + G +SF C E + C G W+P
Sbjct: 2081 HFCEKPPSVSYSILE-----SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS 2135
Query: 419 TPSCGDI---CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWS 474
S I C PP I +G Y S+YS F + Y C+KG+ + G+ K +C + WS
Sbjct: 2136 PMSIQCIPVRCGEPPSIMNG-YASGSNYS-FGAMVAYSCNKGFYIKGEKKSTCEATGQWS 2193
Query: 475 APAPQCKALC--RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
+P P C + P++ NG L + E E V QC+ GY VG C NR W+
Sbjct: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWH 2252
Query: 533 PEVP 536
E P
Sbjct: 2253 SESP 2256
Score = 195 bits (496), Expect = 9e-50
Identities = 156/526 (29%), Positives = 222/526 (42%), Gaps = 90/526 (17%)
Query: 77 LKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTDLSFGSQ 135
++YTC G++ ++ C ++G W T C+ RC P +L NG E D F +
Sbjct: 2855 IEYTCNEGFLLE-GARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTE-GLDYGFMKE 2912
Query: 136 IEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAY 195
+ F C EG+ L G+ C+ W +P C+ V C PP D+ +G +G + +
Sbjct: 2913 VTFHCHEGYILHGAPKLTCQSDGN---WDAEIPLCKPVNCGPPEDLAHGFPNGFS--FIH 2967
Query: 196 GFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
G + Y C P + L G++S C G W S P+C C P + +G + G
Sbjct: 2968 GGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSCLPCRCSTPVIEYGTVN---GT 3020
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHA------S 309
++ +C KGF L G S I C+AD +W+ P CE SC +LP IP+A S
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSS 3080
Query: 310 WE----TY------------------------PRPTKE-----------------DVYVV 324
W+ TY P P E + +
Sbjct: 3081 WKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTY 3140
Query: 325 GTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ-GCEALCCPEPKLNNGEITQHRKSRP 383
+ ++ RC GY TD T CQK+ RW P + C CP P+ N I H
Sbjct: 3141 ESEVKLRCLEGYTMDTD-TDTFTCQKDGRWFPERISCSPKKCPLPE-NITHILVHGDDFS 3198
Query: 384 ANHCVYFYGDEISFSCHETSRFS----AICQGDGTWSP--RTPSCGDI-CNFPPKIAHGH 436
N ++S SC E F ++CQ DGTW P SC + C P HG
Sbjct: 3199 VNR-------QVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHG- 3250
Query: 437 YKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQCK-ALCRKP-ELVNGR 493
+ S Y+ F+ IIY+C+ GY L G + C + WS CK C P E +NG+
Sbjct: 3251 FVVGSKYT-FESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGK 3309
Query: 494 LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
D + NV C+ GY + GP C+ N TW VP C+
Sbjct: 3310 --ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK 3353
Score = 189 bits (481), Expect = 5e-48
Identities = 142/508 (27%), Positives = 222/508 (43%), Gaps = 58/508 (11%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF-- 107
C PP++S++ ++ + +F G+ + + C+ G+V + S + + C G+W +
Sbjct: 2083 CEKPPSVSYSILESVS--KAKFAAGSVVSFKCMEGFVLNTSAK-IECMRGGQWNPSPMSI 2139
Query: 108 -CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
CI RC P + NG ++ SFG+ + +SC++GF++ G S CE + WS P
Sbjct: 2140 QCIPVRCGEPPSIMNGYAS-GSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSP 2195
Query: 167 LPQCEIVKCKPPPDIRNG--RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
+P C V C PP + NG H+ F + V Y C+P + +G C
Sbjct: 2196 IPTCHPVSCGEPPKVENGFLEHTTGRIFES---EVRYQCNPGYKSVGSPVFVCQANRH-- 2250
Query: 225 GVWRP-SPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD 282
W SP C + C KP + +G M G + + F C +G+ L G S C
Sbjct: 2251 --WHSESPLMCVPLDCGKPPPIQNGFMK---GENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305
Query: 283 ADSKWNP-SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTD 341
KWN S P C P C P+ P + + +V VV + C G+
Sbjct: 2306 KSGKWNKKSNPKCMPAKC---PEPPLLENQLVLKELTTEVGVV----TFSCKEGH--VLQ 2356
Query: 342 EPTTVICQKNLRWTP-YQGCE-ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC 399
P+ + C + +W + C+ LC P P ++ G P +G + +SC
Sbjct: 2357 GPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGV--------PIPSSALHFGSTVKYSC 2408
Query: 400 ----HETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYK-QSSSYSFFKEEIIYE 453
+ +CQ DGTWS P C + C P +I +G Q +Y +Y
Sbjct: 2409 VGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYL---STALYT 2465
Query: 454 CDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-CRKP-ELVNGRLSVDKDQYVEPENVTIQ 510
C G+ LVG C + HW P CKA+ C KP E++NG+ S Y + VT
Sbjct: 2466 CKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQTVTYS 2523
Query: 511 CDSGYGVVGPQSITCSGNRTWYPEVPKC 538
C+ G+ + GP ++TC W + P C
Sbjct: 2524 CNRGFRLEGPSALTCLETGDWDVDAPSC 2551
Score = 178 bits (452), Expect = 1e-44
Identities = 148/525 (28%), Positives = 216/525 (41%), Gaps = 99/525 (18%)
Query: 74 GTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132
G T+ Y+C G+ R LTC G+W V C C P + NG VE D S+
Sbjct: 2517 GQTVTYSCNRGF-RLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVE-GADYSY 2574
Query: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR------- 185
G+ I +SC GF + G CE GWS +P C + C PP I G
Sbjct: 2575 GAIIIYSCFPGFQVAGHAMQTCEES----GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDD 2630
Query: 186 ----------------------HSG---------------EENFYAYGFSVTYSCDPRFS 208
H G + + YG V+Y+C+P +
Sbjct: 2631 QGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYE 2690
Query: 209 LLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDT-----I 263
LLG+ + C + G W S P+C I C P +GF + +T +
Sbjct: 2691 LLGNPVLICQED----GTWNGSAPSCISIECDLPTAPE----NGF---LRFTETSMGSAV 2739
Query: 264 VFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV 323
+ C+ G +L GS + C + KW+ + P CE SC + + S K Y
Sbjct: 2740 QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGS-------IKGSNYT 2792
Query: 324 VGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCCPEPKLN-NGEITQHRKS 381
+ L Y C PGY E T CQ + W + C + C P ++ NG++
Sbjct: 2793 YLSTLYYECDPGYVLNGTERRT--CQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDE-- 2848
Query: 382 RPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGH 436
Y + EI ++C+E S +C +G+WS TP C + C PP++A+G
Sbjct: 2849 -------YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANG- 2900
Query: 437 YKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKPE-LVNGR 493
+ Y F K E+ + C +GYIL G KL+C S +W A P CK + C PE L +G
Sbjct: 2901 VTEGLDYGFMK-EVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG- 2958
Query: 494 LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ ++ ++ QC GY + G S C N +W P C
Sbjct: 2959 -FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC 3002
Score = 172 bits (435), Expect = 1e-42
Identities = 152/528 (28%), Positives = 222/528 (42%), Gaps = 62/528 (11%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKT-GTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF 107
+C PP + A+P ET + G Y C GY + ++Q L CN+ G+WV
Sbjct: 2020 SCDEPPIVDHASP------ETAHRLFGDIAFYYCSDGYSLADNSQLL-CNAQGKWVPPEG 2072
Query: 108 -----CIYKRCRHPGELRNGQVEIKTDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
CI C P + +E + F GS + F C EGF L S C RG
Sbjct: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM---RG 2129
Query: 161 VGWSHPLP---QCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217
W+ P P QC V+C PP I NG SG Y++G V YSC+ F + G +C
Sbjct: 2130 GQWN-PSPMSIQCIPVRCGEPPSIMNGYASGSN--YSFGAMVAYSCNKGFYIKGEKKSTC 2186
Query: 218 TVENETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGS 276
E G W PTC ++C +P V +G + G I+ + + ++C G+ GS
Sbjct: 2187 ----EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF--ESEVRYQCNPGYKSVGS 2240
Query: 277 SVIHCDADSKWNP-SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
V C A+ W+ SP C P C P I + K + + VG+ +++ C+ G
Sbjct: 2241 PVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM-------KGENFEVGSKVQFFCNEG 2293
Query: 336 YKPTTDEPTTVICQKNLRWTPYQG--CEALCCPEPKLNNGEITQHRKSRPANHCVYFYGD 393
Y+ D T CQK+ +W C CPEP L ++ +
Sbjct: 2294 YELVGDSSWT--CQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVG-------- 2343
Query: 394 EISFSCHETSRFSAI----CQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKE 448
++FSC E C W+ P C + C PP I+ G SS+ F
Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF-GS 2402
Query: 449 EIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELV-NGRLSVDKDQYVEPE 505
+ Y C G+ L G + C WS+P P+C + C +PE + NG + V Y+
Sbjct: 2403 TVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTA 2462
Query: 506 NVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGK 553
T C G+ +VG + C N W P C+ +++L GK
Sbjct: 2463 LYT--CKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGK 2508
Score = 169 bits (428), Expect = 7e-42
Identities = 141/532 (26%), Positives = 216/532 (40%), Gaps = 52/532 (9%)
Query: 69 TRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIK 127
+ F GT + YTC PGY L C DG W + CI C P NG +
Sbjct: 2673 SNFLYGTMVSYTCNPGY-ELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRF- 2730
Query: 128 TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS 187
T+ S GS +++SC G L GS C +++R WS P+CE + CK P + NG
Sbjct: 2731 TETSMGSAVQYSCKPGHILAGSDLRLC-LENR--KWSGASPRCEAISCKKPNPVMNGSIK 2787
Query: 188 GEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHG 247
G Y Y ++ Y CDP + L G +C + W P C + C P VS
Sbjct: 2788 GSN--YTYLSTLYYECDPGYVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSAN 2841
Query: 248 EMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307
V G Y ++ I + C +GF+L G+ C A+ W+ + P C P C P + +
Sbjct: 2842 GQVR--GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLAN 2899
Query: 308 ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCP 366
E ++V + CH GY + CQ + W C+ + C
Sbjct: 2900 GVTEGLDYGFMKEV-------TFHCHEGY--ILHGAPKLTCQSDGNWDAEIPLCKPVNCG 2950
Query: 367 EPK-LNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF----SAICQGDGTWSPRTPS 421
P+ L +G N + +G I + C + S C +G+WS +PS
Sbjct: 2951 PPEDLAHGF---------PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPS 3001
Query: 422 CGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQC 480
C P I +G + + K I +C KG+ L+G ++++C + WS+ P C
Sbjct: 3002 CLPCRCSTPVIEYGTV-NGTDFDCGKAARI-QCFKGFKLLGLSEITCEADGQWSSGFPHC 3059
Query: 481 K-ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
+ C ++ + + E +T C SGY + G + C+ W P CE
Sbjct: 3060 EHTSCGSLPMIPNAFISETSSWKE-NVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCE 3118
Query: 540 ----WETPEGCEQVLTGKRLMQCLPNPEDVKM-ALEVYKLSLEIEQLELQRD 586
P V TG + +VK+ LE Y + + + Q+D
Sbjct: 3119 PLSCGSPPSVANAVATG----EAHTYESEVKLRCLEGYTMDTDTDTFTCQKD 3166
Score = 169 bits (427), Expect = 9e-42
Identities = 129/498 (25%), Positives = 211/498 (42%), Gaps = 49/498 (9%)
Query: 60 APMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTFCIYKRCRHPGE 118
AP + L T G+ ++Y+C PG++ + S L C + +W + C C+ P
Sbjct: 2722 APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRL-CLENRKWSGASPRCEAISCKKPNP 2780
Query: 119 LRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPP 178
+ NG ++ ++ ++ S + + C G+ L G+ C+ D+ W P C V C P
Sbjct: 2781 VMNGSIK-GSNYTYLSTLYYECDPGYVLNGTERRTCQ-DDK--NWDEDEPICIPVDCSSP 2836
Query: 179 PDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT 238
P NG+ G+E Y + + Y+C+ F L G S C G W + P C +
Sbjct: 2837 PVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRVCLAN----GSWSGATPDCVPVR 2890
Query: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNS 298
C P + G Y + + F C +G++L G+ + C +D W+ P C+P +
Sbjct: 2891 CATPPQLANGVTEGLD--YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVN 2948
Query: 299 CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PY 357
C D+ H +P ++ G ++Y+C PGYK + C N W+
Sbjct: 2949 CGPPEDLAHG----FPNGFS---FIHGGHIQYQCFPGYKLHGNSSRR--CLSNGSWSGSS 2999
Query: 358 QGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDG 413
C C P + G + N + G C + + + C+ DG
Sbjct: 3000 PSCLPCRCSTPVIEYGTV---------NGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
Query: 414 TWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSCSYS 471
WS P C C P I + ++SS+ KE +I Y C GY++ G + L C+
Sbjct: 3051 QWSSGFPHCEHTSCGSLPMIPNAFISETSSW---KENVITYSCRSGYVIQGSSDLICTEK 3107
Query: 472 H-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGV-VGPQSITCSGN 528
WS P P C+ L C P V ++ + E E V ++C GY + + TC +
Sbjct: 3108 GVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESE-VKLRCLEGYTMDTDTDTFTCQKD 3166
Query: 529 RTWYPEVPKCEWETPEGC 546
W+PE C +P+ C
Sbjct: 3167 GRWFPERISC---SPKKC 3181
Score = 168 bits (426), Expect = 1e-41
Identities = 139/559 (24%), Positives = 239/559 (42%), Gaps = 80/559 (14%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TF 107
+CG P A P + + E F G+ + Y C GY + ++ +C ++ W ++
Sbjct: 1846 SCGKP-----AIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKES-SCLANSSWSHSPPV 1899
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
C +C P + NG+ I + L++ S +SC G+ L G + C G+ W
Sbjct: 1900 CEPVKCSSPENINNGKY-ILSGLTYLSTASYSCDTGYSLQGPSIIECTAS--GI-WDRAP 1955
Query: 168 PQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227
P C +V C PP I++ +G N + + +VTY+C ++L G +I C + G W
Sbjct: 1956 PACHLVFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGYTLAGLDTIECLAD----GKW 2009
Query: 228 RPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK 286
S C ++C +P V H + + D + C G+ L +S + C+A K
Sbjct: 2010 SRSDQQCLAVSCDEPPIVDHASPETAH---RLFGDIAFYYCSDGYSLADNSQLLCNAQGK 2066
Query: 287 WNP----SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342
W P P C + C P + ++ E+ + + G+V+ ++C G+ T
Sbjct: 2067 WVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK----FAAGSVVSFKCMEGFVLNTS- 2121
Query: 343 PTTVICQKNLRWTP----YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFS 398
+ C + +W P Q C P + NG A+ Y +G +++S
Sbjct: 2122 -AKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY---------ASGSNYSFGAMVAYS 2171
Query: 399 CHE----TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYE 453
C++ + C+ G WS P+C + C PPK+ +G + + ++ F+ E+ Y+
Sbjct: 2172 CNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENG-FLEHTTGRIFESEVRYQ 2230
Query: 454 CDKGYILVGQAKLSCSYS-HWSAPAP-QCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQ 510
C+ GY VG C + HW + +P C L C KP + + + + V
Sbjct: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGF-MKGENFEVGSKVQFF 2289
Query: 511 CDSGYGVVGPQSITCSGNRTWYPEV-PKC------------------EWETPEG-----C 546
C+ GY +VG S TC + W + PKC E T G C
Sbjct: 2290 CNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSC 2349
Query: 547 EQ--VLTGKRLMQCLPNPE 563
++ VL G +++CLP+ +
Sbjct: 2350 KEGHVLQGPSVLKCLPSQQ 2368
Score = 166 bits (420), Expect = 6e-41
Identities = 130/507 (25%), Positives = 204/507 (40%), Gaps = 58/507 (11%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107
NCGPP L+ P + F G ++Y C PGY + H + C S+G W ++
Sbjct: 2948 NCGPPEDLAHGFPNGFS-----FIHGGHIQYQCFPGY-KLHGNSSRRCLSNGSWSGSSPS 3001
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
C+ RC P + G V TD G C +GF L+G + CE + WS
Sbjct: 3002 CLPCRCSTP-VIEYGTVN-GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGF 3056
Query: 168 PQCEIVKCKPPPDIRNG----RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
P CE C P I N S +EN +TYSC + + G + + CT +
Sbjct: 3057 PHCEHTSCGSLPMIPNAFISETSSWKENV------ITYSCRSGYVIQGSSDLICTEK--- 3107
Query: 224 IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL-RGSSVIHCD 282
GVW P CE ++C P + +G + Y+ + +C +G+ + + C
Sbjct: 3108 -GVWSQPYPVCEPLSCGSPPSVANAVATG--EAHTYESEVKLRCLEGYTMDTDTDTFTCQ 3164
Query: 283 ADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342
D +W P +C P C +I H D + V + C GY T +
Sbjct: 3165 KDGRWFPERISCSPKKCPLPENITHIL-------VHGDDFSVNRQVSVSCAEGY--TFEG 3215
Query: 343 PTTVICQKNLRWTPY---QGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC 399
+CQ + W P + C + C +P+ K Y + I + C
Sbjct: 3216 VNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSK--------YTFESTIIYQC 3267
Query: 400 HETSRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
+CQ + WS C + C P + +G K ++Y C
Sbjct: 3268 EPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG--KADIENRTTGPNVVYSC 3325
Query: 455 DKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCD 512
++GY L G ++ C+ + WS P P CK C P ++ + + ++ +NV+I+C
Sbjct: 3326 NRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCR 3385
Query: 513 SGYGVVGPQSITCSGNRTWYPEVPKCE 539
G+ + G ITC+ + TW KCE
Sbjct: 3386 EGFLLQGHGIITCNPDETWTQTSAKCE 3412
Score = 158 bits (400), Expect = 1e-38
Identities = 134/521 (25%), Positives = 213/521 (40%), Gaps = 63/521 (12%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTFC 108
CG PP + D +T F T+ YTC GY + T+ C +DG+W + C
Sbjct: 1963 CGEPPAIK-----DAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIECLADGKWSRSDQQC 2016
Query: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP-- 166
+ C P + + E L FG + CS+G+ L ++ C Q + W P
Sbjct: 2017 LAVSCDEPPIVDHASPETAHRL-FGDIAFYYCSDGYSLADNSQLLCNAQGK---WVPPEG 2072
Query: 167 --LPQCEIVKCKPPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
+P+C C+ PP + S + +A G V++ C F L A I C
Sbjct: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM----R 2128
Query: 224 IGVWRPSPPT--CEKITCRKPDVSHGEMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVI 279
G W PSP + C + C +P +++G+ G Y++ + + C KGF ++G
Sbjct: 2129 GGQWNPSPMSIQCIPVRCGEPP----SIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKS 2184
Query: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWE-TYPRPTKEDVYVVGTVLRYRCHPGYKP 338
C+A +W+ P C P SC P + + E T R + +V RY+C+PGYK
Sbjct: 2185 TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEV-------RYQCNPGYKS 2237
Query: 339 TTDEPTTVICQKNLRW---TPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
+CQ N W +P C P + NG + + G ++
Sbjct: 2238 VGS--PVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN---------FEVGSKV 2286
Query: 396 SFSCHE----TSRFSAICQGDGTWSPRT-PSCGDI-CNFPPKIAHGHYKQSSSYSFFKEE 449
F C+E S CQ G W+ ++ P C C PP + + + +
Sbjct: 2287 QFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEV--GV 2344
Query: 450 IIYECDKGYILVGQAKLSCSYS-HWSAPAPQCK-ALCRKPELVNGRLSVDKDQYVEPENV 507
+ + C +G++L G + L C S W+ P CK LC P L++ + + V
Sbjct: 2345 VTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTV 2404
Query: 508 TIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548
C G+ + G + C + TW +P+C P C Q
Sbjct: 2405 KYSCVGGFFLRGNSTTLCQPDGTWSSPLPEC---VPVECPQ 2442
Score = 155 bits (392), Expect = 1e-37
Identities = 142/552 (25%), Positives = 227/552 (41%), Gaps = 104/552 (18%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTT-------LKYTCLPGYVRSHSTQTLTCNSDGE 101
+CG PP + E F TT ++Y C PGY +S + C ++
Sbjct: 2203 SCGEPPKV-----------ENGFLEHTTGRIFESEVRYQCNPGY-KSVGSPVFVCQANRH 2250
Query: 102 WVYNT--FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDR 159
W + C+ C P ++NG ++ + + GS+++F C+EG+ L+G ++ C+ +
Sbjct: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGE-NFEVGSKVQFFCNEGYELVGDSSWTCQKSGK 2309
Query: 160 GVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTV 219
S+P +C KC PP + N + +E G VT+SC L G + + C
Sbjct: 2310 WNKKSNP--KCMPAKCPEPPLLEN-QLVLKELTTEVGV-VTFSCKEGHVLQGPSVLKCLP 2365
Query: 220 ENETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
+ W S P C+ + C P +S G + ++ T+ + C GF LRG+S
Sbjct: 2366 SQQ----WNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYSCVGGFFLRGNST 2419
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKP 338
C D W+ P C P C +IP+ + + + + T L Y C PG++
Sbjct: 2420 TLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDV------QGLAYLSTAL-YTCKPGFEL 2472
Query: 339 TTDEPTTVICQKNLRWTPYQ-GCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISF 397
+ TT +C +N W + C+A+ C +PK EI + S H YG +++
Sbjct: 2473 VGN--TTTLCGENGHWLGGKPTCKAIECLKPK----EILNGKFSYTDLH----YGQTVTY 2522
Query: 398 SCHETSRF----SAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIY 452
SC+ R + C G W PSC I C+ P I +G + + + YS + IIY
Sbjct: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENG-FVEGADYS-YGAIIIY 2580
Query: 453 ECDKGYILVGQAKLSCSYSHWSAPAPQCKAL------------CRKPELVNGRLSVDKDQ 500
C G+ + G A +C S WS+ P C + C K + G + D
Sbjct: 2581 SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
Query: 501 ----YVEP-------------EN-----------------VTIQCDSGYGVVGPQSITCS 526
YV P EN V+ C+ GY ++G + C
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
Query: 527 GNRTWYPEVPKC 538
+ TW P C
Sbjct: 2701 EDGTWNGSAPSC 2712
Score = 148 bits (373), Expect = 2e-35
Identities = 125/485 (25%), Positives = 204/485 (42%), Gaps = 52/485 (10%)
Query: 75 TTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTDLSFG 133
+T Y+C GY + C + G W C C P +++ + + +F
Sbjct: 1925 STASYSCDTGY-SLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVIT-GNNFTFR 1982
Query: 134 SQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFY 193
+ + ++C EG+ L G T C + WS QC V C PP + + S E
Sbjct: 1983 NTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVDHA--SPETAHR 2037
Query: 194 AYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKP-DVSHGEMVSG 252
+G Y C +SL ++ + C + + + P C C KP VS+ + S
Sbjct: 2038 LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESV 2097
Query: 253 FGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPA--CEPNSCINLPDIPHASW 310
+ + FKC +GFVL S+ I C +WNPSP + C P C P I +
Sbjct: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY- 2156
Query: 311 ETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEP- 368
Y G ++ Y C+ G+ ++ +T C+ +W+ P C + C EP
Sbjct: 2157 ------ASGSNYSFGAMVAYSCNKGFYIKGEKKST--CEATGQWSSPIPTCHPVSCGEPP 2208
Query: 369 KLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTP-SCG 423
K+ NG + +H R + E+ + C+ + +CQ + W +P C
Sbjct: 2209 KVENGFL-EHTTGR-------IFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCV 2260
Query: 424 DI-CNFPPKIAHG-----HYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAP 476
+ C PP I +G +++ S FF C++GY LVG + +C S W+
Sbjct: 2261 PLDCGKPPPIQNGFMKGENFEVGSKVQFF-------CNEGYELVGDSSWTCQKSGKWNKK 2313
Query: 477 A-PQCK-ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPE 534
+ P+C A C +P L+ +L V K+ E VT C G+ + GP + C ++ W
Sbjct: 2314 SNPKCMPAKCPEPPLLENQL-VLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDS 2372
Query: 535 VPKCE 539
P C+
Sbjct: 2373 FPVCK 2377
Score = 147 bits (370), Expect = 4e-35
Identities = 122/463 (26%), Positives = 186/463 (40%), Gaps = 84/463 (18%)
Query: 129 DLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSG 188
DL GS++ C GF L+G+ C Q + W+ PLP CE + C PP + NG HS
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFHSA 1703
Query: 189 EENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC-------------- 234
++ FYA G +VTY C+ + LLG + + CT G W P+C
Sbjct: 1704 DD-FYA-GSTVTYQCNNGYYLLGDSRMFCTDN----GSWNGVSPSCLDVDECAVGSDCSE 1757
Query: 235 ---------------------------EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267
E I C+ P + E G IY + F C
Sbjct: 1758 HASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAP--GNPENGHSSGEIYTVGAEVTFSC 1815
Query: 268 QKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTV 327
Q+G+ L G + I C +WN P C+ SC P IP +E + G+
Sbjct: 1816 QEGYQLMGVTKITCLESGEWNHLIPYCKAVSC-GKPAIPENGC------IEELAFTFGSK 1868
Query: 328 LRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPK-LNNGEITQHRKSRPANH 386
+ YRC+ GY D+ ++ + + +P CE + C P+ +NNG+ +
Sbjct: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSP-PVCEPVKCSSPENINNGKYILSGLT----- 1922
Query: 387 CVYFYGDEISFSC---HETSRFSAI-CQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSS 441
Y S+SC + S I C G W P+C + C PP I +
Sbjct: 1923 ----YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVI--TG 1976
Query: 442 SYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKPELVNGRLSVDKD 499
+ F+ + Y C +GY L G + C + WS QC A+ C +P +V+ S +
Sbjct: 1977 NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVD-HASPETA 2035
Query: 500 QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYP----EVPKC 538
+ + C GY + + C+ W P ++P+C
Sbjct: 2036 HRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
Score = 132 bits (331), Expect = 1e-30
Identities = 102/391 (26%), Positives = 154/391 (39%), Gaps = 46/391 (11%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF- 107
+CG PP+++ A T + +K CL GY T T TC DG W
Sbjct: 3121 SCGSPPSVANAVA-----TGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERIS 3175
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
C K+C P + + V D S Q+ SC+EG+ G S C++ W P
Sbjct: 3176 CSPKKCPLPENITHILVH-GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT---WEPPF 3231
Query: 168 PQ--CEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225
C V C P +G G + Y + ++ Y C+P + L G+ C +
Sbjct: 3232 SDESCSPVSCGKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQ--- 3286
Query: 226 VWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKD--TIVFKCQKGFVLRGSSVIHCDA 283
W C++ C P E ++G I N +V+ C +G+ L G S HC
Sbjct: 3287 -WSGGVAICKETRCETPL----EFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTE 3341
Query: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343
+ W+ P C+PN C +P E KE + V + +C G+
Sbjct: 3342 NGTWSHPVPLCKPNPC----PVPFVIPENALLSEKE--FYVDQNVSIKCREGF--LLQGH 3393
Query: 344 TTVICQKNLRWTPYQG-CEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE- 401
+ C + WT CE + C P H ++ A Y YGD I++SC+
Sbjct: 3394 GIITCNPDETWTQTSAKCEKISCGPP--------AHVENAIARGVHYQYGDMITYSCYSG 3445
Query: 402 ---TSRFSAICQGDGTWSPRTPSCGDICNFP 429
++C +GTW+ P C +C FP
Sbjct: 3446 YMLEGFLRSVCLENGTWT-SPPICRAVCRFP 3475
Score = 127 bits (319), Expect = 3e-29
Identities = 120/487 (24%), Positives = 187/487 (38%), Gaps = 91/487 (18%)
Query: 65 TLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TFCIYKRCRHPGELRNGQ 123
T+ T F G + C G+ + +TC +DG+W C + C + N
Sbjct: 3016 TVNGTDFDCGKAARIQCFKGF-KLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAF 3074
Query: 124 VEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRN 183
+ +T + I +SC G+ + GS+ C ++GV WS P P CE + C PP + N
Sbjct: 3075 IS-ETSSWKENVITYSCRSGYVIQGSSDLICT--EKGV-WSQPYPVCEPLSCGSPPSVAN 3130
Query: 184 GRHSGEENFY--------------------------AYGFSVTYSCDPR----------- 206
+GE + Y F SC P+
Sbjct: 3131 AVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHI 3190
Query: 207 ------FSLLGHASISC----TVENETI------GVWRP--SPPTCEKITCRKPDV-SHG 247
FS+ S+SC T E I G W P S +C ++C KP+ HG
Sbjct: 3191 LVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHG 3250
Query: 248 EMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307
+V G Y ++ TI+++C+ G+ L G+ C + +W+ C+ C + +
Sbjct: 3251 FVV---GSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLN 3307
Query: 308 ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCP 366
+ R T +V Y C+ GY + + P+ C +N W+ P C+ CP
Sbjct: 3308 GKADIENRTTGPNVV-------YSCNRGY--SLEGPSEAHCTENGTWSHPVPLCKPNPCP 3358
Query: 367 EPKLNNGEITQHRKSRPANHCVYFYGDE-ISFSCHETSRFSA----ICQGDGTWSPRTPS 421
P + K FY D+ +S C E C D TW+ +
Sbjct: 3359 VPFVIPENALLSEKE--------FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAK 3410
Query: 422 CGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQC 480
C I PP + Y + + I Y C GY+L G + C W++P P C
Sbjct: 3411 CEKISCGPPAHVENAIARGVHYQY-GDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PIC 3468
Query: 481 KALCRKP 487
+A+CR P
Sbjct: 3469 RAVCRFP 3475
Score = 81.6 bits (200), Expect = 2e-15
Identities = 76/298 (25%), Positives = 118/298 (39%), Gaps = 39/298 (13%)
Query: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGT 326
C GF L G+ V +C +W P CE SC P + + D + G+
Sbjct: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA-------DDFYAGS 1710
Query: 327 VLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANH 386
+ Y+C+ GY D + + C N W G C + G S
Sbjct: 1711 TVTYQCNNGYYLLGD--SRMFCTDNGSWN---GVSPSCLDVDECAVGSDCSEHAS----- 1760
Query: 387 CVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDI--CNFPPKIAHGHYKQSSSYS 444
C+ G S+ C ++ GDG +C + C P +GH S
Sbjct: 1761 CLNVDG---SYICSCVPPYT----GDGK------NCAEPIKCKAPGNPENGH--SSGEIY 1805
Query: 445 FFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPELV-NGRLSVDKDQY 501
E+ + C +GY L+G K++C S W+ P CKA+ C KP + NG +++ +
Sbjct: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG--CIEELAF 1863
Query: 502 VEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCL 559
VT +C+ GY + G + +C N +W P CE E + GK ++ L
Sbjct: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGL 1921
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/176 (27%), Positives = 74/176 (42%), Gaps = 24/176 (13%)
Query: 170 CEIVKC---KPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226
CE+V C KPP + +++ +F A + C P F L+G + I C G+
Sbjct: 373 CELVHCPALKPPENGYFIQNTCNNHFNA---ACGVRCHPGFDLVGSSIILCLPN----GL 425
Query: 227 WRPSPPTCEKITC---RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
W S C TC R+P HG + + YK T + C +G+ L GS + C
Sbjct: 426 WSGSESYCRVRTCPHLRQP--KHGHISCSTREML-YKTTCLVACDEGYRLEGSDKLTCQG 482
Query: 284 DSKWNPSPPACEPNSC--INLP-DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
+S+W+ P C C +P D+ + +P K GT+ C G+
Sbjct: 483 NSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK-----FGTICYVSCRQGF 533
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 9/115 (7%)
Query: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKALC--- 484
PP+ +G++ Q++ + F C G+ LVG + + C + WS C+
Sbjct: 383 PPE--NGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPH 440
Query: 485 -RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
R+P+ +G +S + + + CD GY + G +TC GN W P+C
Sbjct: 441 LRQPK--HGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRC 493
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/224 (23%), Positives = 83/224 (37%), Gaps = 27/224 (12%)
Query: 132 FGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEEN 191
F + C GF L+GS+ C G+ WS C + C ++G S
Sbjct: 398 FNAACGVRCHPGFDLVGSSIILC--LPNGL-WSGSESYCRVRTCPHLRQPKHGHISCSTR 454
Query: 192 FYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVS 251
Y + +CD + L G ++C ++ W P C + C + ++S
Sbjct: 455 EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRCVERHCSTFQMPKDVIIS 510
Query: 252 ----GFGPIYNYKDTIVFKCQKGFVLRG-SSVIHCDADSKWNPSPPA--CEPNSC--INL 302
G P + C++GF+L G ++ C KWN A C+ IN
Sbjct: 511 PHNCGKQPA-KFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
Query: 303 P-DIPHASWE-------TYPRPTKEDVYVVGTVLRYRCHPGYKP 338
P DI + E T+ PT +D G + HP + P
Sbjct: 570 PKDIEAKTLEQQDSANVTWQIPTAKD--NSGEKVSVHVHPAFTP 611
Score = 33.1 bits (74), Expect = 0.75
Identities = 48/223 (21%), Positives = 79/223 (35%), Gaps = 40/223 (17%)
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYP-------RPTKEDVYVVGTVL 328
SS I C ++ +P P + P C+ AS +T +P + ++ T
Sbjct: 338 SSCIPCPDENHTSP-PGSTSPEDCVCREGY-RASGQTCELVHCPALKPPENGYFIQNTCN 395
Query: 329 RY-------RCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCCP---EPKLNNGEITQ 377
+ RCHPG+ + ++C N W+ + C CP +PK +G I+
Sbjct: 396 NHFNAACGVRCHPGFDLVGS--SIILCLPNGLWSGSESYCRVRTCPHLRQPK--HGHISC 451
Query: 378 HRKSRPANHCVYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTPSCGD----ICNFP 429
+ Y +C E R CQG+ W P C + P
Sbjct: 452 STREM-------LYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMP 504
Query: 430 PKIAHGHYKQSSSYSFFKEEIIYECDKGYILVG-QAKLSCSYS 471
+ + + F C +G+IL G + L C+ S
Sbjct: 505 KDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTS 547
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 204 bits (520), Expect = 1e-52
Identities = 153/552 (27%), Positives = 236/552 (42%), Gaps = 56/552 (10%)
Query: 36 MTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLT 95
+ + LL + C P L FA P ++T + F GT L Y C PGY S ++
Sbjct: 21 LAALVLLLSSFSDQCNVPEWLPFARPTNLT-DDFEFPIGTYLNYECRPGY--SGRPFSII 77
Query: 96 CNSDGEWVY-NTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRC 154
C + W C K CR+P + NG + D+ F SQI++SC +G+ LIGS+++ C
Sbjct: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137
Query: 155 EVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSG-EENFYAYGFSVTYSCD------PRF 207
+ V W + P C+ + C PP I NG + ++ YG VTY C+ F
Sbjct: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197
Query: 208 SLLGHASISCTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFK 266
L+G SI CT +++ +G+W P+P C P+V +G +VS +++ + + F+
Sbjct: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
Query: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGT 326
CQ GF ++G S + C A +KW P P+C C PD+ HA +D + G
Sbjct: 258 CQPGFGMKGPSHVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQ 312
Query: 327 VLRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPE--PKLNNGEITQHRKSRP 383
+ Y C PGY T + C W+P CE C + +L NG + P
Sbjct: 313 EVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL-----FP 365
Query: 384 ANHCVYFYGDEISFSCHE-------TSRFSAICQGDGTWSPRTPSC-GDICNFPPKIAHG 435
N G ++ F C E ++ + + + W+ P C C PP +G
Sbjct: 366 LN---LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG 422
Query: 436 HYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS----HWSAPAPQCKALC--RKPEL 489
+ I Y C G+ L+G + C S HWS P C+ + P +
Sbjct: 423 MVHVITDI-HVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAI 481
Query: 490 VNGR-LSVDKDQYVEPENVTIQCD------SGYGVVGPQSITCS----GNRTWYPEVPKC 538
+NGR + V+ CD + ++G +I + GN W P+C
Sbjct: 482 LNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
Query: 539 EWETPEGCEQVL 550
E G L
Sbjct: 542 ELPVGAGSHDAL 553
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 196 bits (499), Expect = 4e-50
Identities = 151/507 (29%), Positives = 223/507 (43%), Gaps = 51/507 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY-VRSHSTQTLTCNSDGEWVYNT- 106
+CG P AP + + T + GT + Y C GY + S T C SDG W +
Sbjct: 2527 SCGIPK-----APTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2581
Query: 107 --FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWS 164
C+ C NG +I T S+GS F+C GF L+GS C G+ WS
Sbjct: 2582 TPRCVVISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVREC--LSSGL-WS 2637
Query: 165 HPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
+C C P I NG+ GE Y Y +V Y C+P F L+G + C ++
Sbjct: 2638 ESETRCLAGHCGIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHN-- 2693
Query: 225 GVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDAD 284
W P+C ++C P SG G +N+ D + F C G++++G + C A+
Sbjct: 2694 --WSGQLPSCVPVSCGHPGSPIYGRTSGNG--FNFNDVVTFSCNIGYLMQGPTKAQCQAN 2749
Query: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
+W+ PP C+ +C + P IP S + + GTV+ Y C+PGY +
Sbjct: 2750 RQWSHPPPMCKVVNCSD-PGIPANS--KRESKIEHGNFTYGTVVFYDCNPGY--FLFGSS 2804
Query: 345 TVICQKNLRW-TPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC---- 399
+ICQ N +W P C + C P + + K Y +G + +SC
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK--------YTFGSTVHYSCTGKR 2856
Query: 400 HETSRFSAICQGDGTWSPRTPSC-GD---ICNFPPKIAHGHYKQSSSYSFFKEEIIYECD 455
+ S CQ +G WS P C GD C P HG ++S+ + K + Y CD
Sbjct: 2857 SLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRT--KSTVRYACD 2914
Query: 456 KGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKP-ELVNGRL-SVDKDQYVEPENVTIQC 511
GYIL G + +C + W+ P+CKA+ C P NG++ +D + +V C
Sbjct: 2915 TGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTF--SSSVIYSC 2972
Query: 512 DSGYGVVGPQSITCSGNRTWYPEVPKC 538
GY + GP C+ N TW +P C
Sbjct: 2973 MEGYILSGPSVRQCTANGTWSGTLPNC 2999
Score = 161 bits (408), Expect = 1e-39
Identities = 140/518 (27%), Positives = 221/518 (42%), Gaps = 54/518 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107
NC P + + + + F GT + Y C PGY S+ L C +G+W
Sbjct: 2763 NCSDPG-IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS-VLICQPNGQWDKPLPE 2820
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
CI C HPG N + + +FGS + +SC+ L+G ++ C++ WS
Sbjct: 2821 CIMIDCGHPGVPPNAVLSGEK-YTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQ 2876
Query: 168 PQCE---IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
P C C P +G S +E+ + +V Y+CD + L G +C
Sbjct: 2877 PHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN---- 2930
Query: 225 GVWRPSPPTCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
G W P C+ + C P + +G++ G ++ ++++ C +G++L G SV C A
Sbjct: 2931 GSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTA 2988
Query: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343
+ W+ + P C SC + P IP A+ Y D YVVG + Y C PGY +
Sbjct: 2989 NGTWSGTLPNCTIISCGD-PGIP-ANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGS 3041
Query: 344 TTVICQKNLRWTPYQ-GCEALCCP-EPKLNNGEITQHRKSRPANHCVYFYGDEISFSC-- 399
C N W+ C A+ CP P+++NG + + +G IS+ C
Sbjct: 3042 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN---------FDWGFSISYICSP 3092
Query: 400 -HETSRFSAI--CQGDGTWSPRTPSC-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECD 455
+E S F A+ C G+GTWS P C C P A G K+ ++ E+ + C+
Sbjct: 3093 GYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCN 3149
Query: 456 KGYILVGQAKLSC-SYSHWSAPAPQC----KALCRKPELVNGRLSVDKDQYVEPENVTIQ 510
+ILVG + C + WS +P C + C P + + + V
Sbjct: 3150 FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFH 3209
Query: 511 CDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548
C G+ + G + TC + TW P+C P C+Q
Sbjct: 3210 CKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPHSCKQ 3244
Score = 159 bits (403), Expect = 5e-39
Identities = 119/439 (27%), Positives = 185/439 (42%), Gaps = 37/439 (8%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH-PLPQCE 171
C P NG + + TD G+++ + C++G+ L + Q G +H P+C
Sbjct: 2528 CGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCV 2586
Query: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSP 231
++ C P NG G + +YG + ++CD F L+G A C + G+W S
Sbjct: 2587 VISCGELPTPPNGNKIGTQT--SYGSTAIFTCDLGFMLVGSAVRECL----SSGLWSESE 2640
Query: 232 PTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPS 290
C C P+ + +G+++ G Y Y+DT+V++C GF L GSSV C D W+
Sbjct: 2641 TRCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQ 2697
Query: 291 PPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQK 350
P+C P SC H Y R T + + V+ + C+ GY PT CQ
Sbjct: 2698 LPSCVPVSC------GHPGSPIYGR-TSGNGFNFNDVVTFSCNIGY--LMQGPTKAQCQA 2748
Query: 351 NLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE----TSRF 405
N +W+ P C+ + C +P G ++ H + YG + + C+
Sbjct: 2749 NRQWSHPPPMCKVVNCSDP----GIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2804
Query: 406 SAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAK 465
ICQ +G W P C I P + Y+ F + Y C L+GQ+
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYT-FGSTVHYSCTGKRSLLGQSS 2863
Query: 466 LSCSYS-HWSAPAPQCK----ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGP 520
+C + HWS P C C P G S + + V CD+GY + G
Sbjct: 2864 RTCQLNGHWSGSQPHCSGDATGTCGDPG-TPGHGSRQESNFRTKSTVRYACDTGYILHGS 2922
Query: 521 QSITCSGNRTWYPEVPKCE 539
+ TC N +W P+C+
Sbjct: 2923 EERTCLANGSWTGRQPECK 2941
Score = 119 bits (299), Expect = 6e-27
Identities = 100/361 (27%), Positives = 146/361 (40%), Gaps = 36/361 (9%)
Query: 74 GTTLK----YTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKT 128
GTT Y+C+ GY+ S C ++G W C C PG NG +
Sbjct: 2961 GTTFSSSVIYSCMEGYILS-GPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRYGD 3018
Query: 129 DLSFGSQIEFSCSEGFF--LIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186
D G + + C G+ L GS C + WS +P C V C PP I NGR
Sbjct: 3019 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRL 3075
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-S 245
G + +GFS++Y C P + L A ++C G W P C C P + +
Sbjct: 3076 EGTN--FDWGFSISYICSPGYELSFPAVLTCVGN----GTWSGEVPQCLPKFCGDPGIPA 3129
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC-EPN--SCINL 302
G+ G + Y+ + F C F+L GSS C AD W+ S P C EP SC N
Sbjct: 3130 QGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN- 3185
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
P +P + + VG+V+++ C G+ TT C +L W+ Q C
Sbjct: 3186 PGVPR-----HGSQNNTFGFQVGSVVQFHCKKGH--LLQGSTTRTCLPDLTWSGIQPECI 3238
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPS 421
C +P+ P++ Y + F + +C+ D TW+ + P
Sbjct: 3239 PHSCKQPE-TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPI 3296
Query: 422 C 422
C
Sbjct: 3297 C 3297
Score = 106 bits (265), Expect = 5e-23
Identities = 88/294 (29%), Positives = 129/294 (43%), Gaps = 31/294 (10%)
Query: 71 FKTGTTLKYTCLPGYVRS-HSTQTLTCNSDGEW--VYNTFCIYKRCRHPGELRNGQVEIK 127
+ G + Y C PGY + ++ TC +G W V T C C P ++ NG++E
Sbjct: 3020 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-CRAVTCPTPPQISNGRLE-G 3077
Query: 128 TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCKPPPDIRNGRH 186
T+ +G I + CS G+ L C G G WS +PQC C P G+
Sbjct: 3078 TNFDWGFSISYICSPGYELSFPAVLTCV----GNGTWSGEVPQCLPKFCGDPGIPAQGKR 3133
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT---CRKPD 243
G+ + Y V++SC+ F L+G ++ C + G W S P C + T C P
Sbjct: 3134 EGKS--FIYQSEVSFSCNFPFILVGSSTRICQAD----GTWSGSSPHCIEPTQTSCENPG 3187
Query: 244 VS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302
V HG + FG + + F C+KG +L+GS+ C D W+ P C P+SC
Sbjct: 3188 VPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSC-KQ 3244
Query: 303 PDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT 355
P+ P HA+ P+ G L Y C PG+ V C+ + WT
Sbjct: 3245 PETPAHANVVGMDLPSH------GYTLIYTCQPGFFLAGGTEHRV-CRSDNTWT 3291
Score = 98.2 bits (243), Expect = 2e-20
Identities = 77/261 (29%), Positives = 113/261 (43%), Gaps = 23/261 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FC 108
C PP +S L T F G ++ Y C PGY S LTC +G W C
Sbjct: 3064 CPTPPQISNGR-----LEGTNFDWGFSISYICSPGYELSFPA-VLTCVGNGTWSGEVPQC 3117
Query: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168
+ K C PG G+ E K+ + + S++ FSC+ F L+GS+T C+ WS P
Sbjct: 3118 LPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3173
Query: 169 QC---EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225
C C+ P R+G + F G V + C L G + +C +
Sbjct: 3174 HCIEPTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDL---- 3228
Query: 226 VWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIH-CDA 283
W P C +C++P+ +H +V P + Y T+++ CQ GF L G + C +
Sbjct: 3229 TWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRS 3286
Query: 284 DSKWNPSPPACEPNSCINLPD 304
D+ W P CE S I + D
Sbjct: 3287 DNTWTGKVPICEAGSKILVKD 3307
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/357 (24%), Positives = 143/357 (40%), Gaps = 40/357 (11%)
Query: 199 VTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIY 257
V ++CD F L+G +S C + W P C+ I+C P ++G +++ Y
Sbjct: 2488 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDY 2544
Query: 258 NYKDTIVFKCQKGFVLRGSSVIH--CDADSKW--NPSPPACEPNSCINLPDIPHASWETY 313
+ + C G+ L + C +D W + P C SC LP P+ +
Sbjct: 2545 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGN---- 2600
Query: 314 PRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ-GCEALCCPEPKL-N 371
+ + Y G+ + C G+ C + W+ + C A C P+L
Sbjct: 2601 -KIGTQTSY--GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSESETRCLAGHCGIPELIV 2655
Query: 372 NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTPSCGDI-C 426
NG++ Y Y D + + C+ R ICQ D WS + PSC + C
Sbjct: 2656 NGQVIGEN---------YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSC 2706
Query: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-C 484
P +G + S + F + + + C+ GY++ G K C + WS P P CK + C
Sbjct: 2707 GHPGSPIYG--RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC 2764
Query: 485 RKPEL-VNGR--LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
P + N + ++ + V C+ GY + G + C N W +P+C
Sbjct: 2765 SDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC 2821
Score = 59.7 bits (143), Expect = 7e-09
Identities = 107/483 (22%), Positives = 161/483 (33%), Gaps = 114/483 (23%)
Query: 82 LPGYVRSHS-TQTLTCNSDGEWVYNTFCI-YKR-----CRHPGELRNGQVEIKTDLSFGS 134
LP + S S T L SDG Y F + YK C PG + NG + D GS
Sbjct: 1559 LPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNG-TRLGMDYKLGS 1617
Query: 135 QIEFSCSEGFFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGE--EN 191
+ + C G+ L G +T C + D G GW+ LP C P R+ G
Sbjct: 1618 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS-----CHAPCGSRSTGSEGTVLSP 1672
Query: 192 FYAYGFSVTYSC---------------------------------DPRFSLLGHASIS-- 216
Y +SV ++C + SLL S S
Sbjct: 1673 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHS 1732
Query: 217 -----------CTVENETIG---------VWRPSPPTCEKITCRKPDVSHGEMVSGFGPI 256
T+ ++G V++ P T P+ G + G
Sbjct: 1733 GESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRI---GNE 1789
Query: 257 YNYKDTIVFKCQKGFVLRGSSVIHCD----ADSKWNPSPPAC-EPNSCINLPDIPHASWE 311
+ +++F C G++L GS I C+ + ++WN S P C P I
Sbjct: 1790 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1849
Query: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQ-----KNLRWTPYQGCEALCCP 366
YP P ++ V +K T E + Q W +
Sbjct: 1850 GYPEPYDNNLNCV-----------WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1898
Query: 367 EPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGD 424
P+L +G H + +N+ + +IS S D P+TPS G
Sbjct: 1899 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG- 1957
Query: 425 ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC---SYSHWSAPAPQCK 481
K Y + + ++CD+GY L G + ++C W+ P P C
Sbjct: 1958 ------------IKIGDRY-MVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2004
Query: 482 ALC 484
A C
Sbjct: 2005 AQC 2007
Score = 56.2 bits (134), Expect = 8e-08
Identities = 60/241 (24%), Positives = 95/241 (39%), Gaps = 35/241 (14%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY + + + C P RNG V I D + G I F C G+ LIG++ C +
Sbjct: 2111 VYQAYQL-QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRN 2167
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTY-SCDPRFSLLGHASISCTVEN 221
W+HPLP+CE + C NG Y+ G+ Y + F L+ + N
Sbjct: 2168 WNHPLPRCEAL-CGGNITAMNG------TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYIN 2220
Query: 222 ETIGVWRPSPPTCEKITC------RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275
T+ + P + IT P + + +Y+ + I+ K F G
Sbjct: 2221 FTV---LQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2277
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
V+ A PP PN+ I T++D + +G ++RY+C PG
Sbjct: 2278 FFVLSYHAYQLRVCQPPPPVPNAEI---------------LTEDDEFEIGDIIRYQCLPG 2322
Query: 336 Y 336
+
Sbjct: 2323 F 2323
Score = 50.4 bits (119), Expect = 5e-06
Identities = 112/479 (23%), Positives = 168/479 (35%), Gaps = 108/479 (22%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY +F + C PG + G GS I + C+ G+ L GS+ +C +R
Sbjct: 1241 VYTSFEL-SHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR-A 1298
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEEN------FYAYGFSVTYSC------DP-RFSL 209
W +PLP C I +C GR GE + Y + + C DP
Sbjct: 1299 WDYPLPSC-IAEC-------GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVS 1350
Query: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYK----DTIVF 265
L + ++ + VW PP + + ++S + G N DT +
Sbjct: 1351 LQFLAFDTEASHDILRVW-DGPPENDMLL---KEISGSLIPEGIHSTLNIVTIQFDTDFY 1406
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVG 325
+ GF ++ SS + AC P +P D G
Sbjct: 1407 ISKSGFAIQFSSSV-----------ATACRD------PGVPMNG------TRNGDGREPG 1443
Query: 326 TVLRYRCHPGYKPTTDEPTTVICQKN-LRWTPYQG-CEALCCPEPKLNNGEITQ------ 377
+ ++C PGY+ +E T I +N W P C A C ++G I
Sbjct: 1444 DTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHP 1503
Query: 378 HRKSRPANHCVYFYGDE------ISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPK 431
+ SR + + D ISFS F I G + SP S D P +
Sbjct: 1504 YPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD-SKLPER 1562
Query: 432 I------AHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCR 485
I H ++ S S+ G+ L +AKL + C
Sbjct: 1563 IESSSNTMHLAFRSDGSVSY----------TGFHLEYKAKL--------------RESCF 1598
Query: 486 KP-ELVNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC----SGNRTWYPEVPKC 538
P ++NG RL +D Y VT CD+GY + G ++TC G W +P C
Sbjct: 1599 DPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Score = 47.0 bits (110), Expect = 5e-05
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQCE 171
C PGE NG+ I +D S GS ++FSC E + L G+ + C+ + + WS P C+
Sbjct: 382 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440
Query: 172 IVKC 175
+ C
Sbjct: 441 VKTC 444
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/232 (20%), Positives = 94/232 (40%), Gaps = 35/232 (15%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQ--H 378
+ +G+ + + C GY+ + +EP ++C+KN W+ P C+ALC + + +G I +
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEP--LLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGY 979
Query: 379 RKSRPAN-HCVYF----YGDEISFSCH-----ETSRFSAICQGDGTWSPRTPSCGDICNF 428
+ P + +C + +G + F+ H + + I + P G +
Sbjct: 980 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGS--DL 1037
Query: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPE 488
PP I G Y F+ ++ + D G + ++S ++ + + +
Sbjct: 1038 PPTINAGLYGN------FRAQLRFISDFSISYEG---FNITFSEYNLEPCEDPGIPQYGS 1088
Query: 489 LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKC 538
+ + + +T C SGY + G I C G R W +P+C
Sbjct: 1089 RIGFNFGIG-------DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1133
Score = 43.1 bits (100), Expect = 7e-04
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P + NG+ G + ++ G +V +SCD + L G SI+C E W P C
Sbjct: 382 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 235 EKITC 239
+ TC
Sbjct: 440 KVKTC 444
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/333 (22%), Positives = 114/333 (34%), Gaps = 92/333 (27%)
Query: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC-DADSK--WNPSPPACE 295
CR P V +G G DT+VF+C G+ L+G I C +++ W PSPP C
Sbjct: 1424 CRDPGVPMNGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1481
Query: 296 PNSCINL---------PDIPHASWETYPRPTKEDV---------YVVGTV-LRYRCHPGY 336
NL P+ PH P P D YV+ + + P Y
Sbjct: 1482 APCGGNLTGSSGFILSPNFPH------PYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1535
Query: 337 K-------PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVY 389
P ++ P Q + PE ++ + T H R ++ V
Sbjct: 1536 DFLYIYDGPDSNSPLIGSFQDSK------------LPE-RIESSSNTMHLAFR-SDGSVS 1581
Query: 390 FYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHG-----HYKQSSSYS 444
+ G + + + SC D P I +G YK S+
Sbjct: 1582 YTGFHLEYK-----------------AKLRESCFD----PGNIMNGTRLGMDYKLGST-- 1618
Query: 445 FFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPAPQCKALCRKPELVNGRLSVDKD 499
+ Y CD GY+L G + L+C W+ P C A C +V
Sbjct: 1619 -----VTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS-RSTGSEGTVLSP 1672
Query: 500 QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
Y P+N ++ + Y + P+ G ++
Sbjct: 1673 NY--PKNYSVGHNCVYSIAVPKEFVVFGQFVFF 1703
Score = 42.0 bits (97), Expect = 0.002
Identities = 57/237 (24%), Positives = 77/237 (32%), Gaps = 64/237 (27%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG +G+ D S GS + FSC G+ L CE + WSHPLP C+
Sbjct: 906 CLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 961
Query: 173 VKCKPPPDIRNGRHS----GEENFYAYGFSVTYSCD-----------PRFSLLGHASISC 217
+ C D+R + G FY + T++ D F L H
Sbjct: 962 L-C--GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLL 1018
Query: 218 TVENETIG------VWRPSPPTCE------------------------KIT--------C 239
EN + PPT IT C
Sbjct: 1019 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1078
Query: 240 RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK--WNPSPPAC 294
P + GF + DT+ F C G+ L G+S I C + W+ P C
Sbjct: 1079 EDPGIPQYGSRIGFN--FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1133
Score = 40.4 bits (93), Expect = 0.005
Identities = 16/40 (40%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Query: 448 EEIIYECDKGYILVGQAKLSCSYS---HWSAPAPQCKALC 484
+ I +EC GY L+G + L+C + +W+ P P+C+ALC
Sbjct: 2140 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2179
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C+PPP + N E++ + G + Y C P F+L+G+A ++C + +PP C
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERL--QMDGAPPVC 2348
Query: 235 E 235
+
Sbjct: 2349 Q 2349
Score = 38.5 bits (88), Expect = 0.018
Identities = 62/263 (23%), Positives = 87/263 (33%), Gaps = 65/263 (24%)
Query: 254 GPIYNYKDTIVFKCQKGFVLRGSSVIHC--DADSKWNPSPPACEP---------NSCINL 302
G + TI F+C G+ L G+S + C WN P CE N I
Sbjct: 2133 GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYS 2192
Query: 303 PDIPHASWETYPR----------PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL 352
P P + YP P +Y+ TVL+ +P D T
Sbjct: 2193 PGYP----DEYPNFQDCFWLVRVPPGNGIYINFTVLQT------EPIYDFITV------- 2235
Query: 353 RWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE---TSRFSAIC 409
+ G P N+ +I Q A VY ++I H TS F +
Sbjct: 2236 ----WDG--------PDQNSPQIGQF-SGNTALESVYSTSNQILIKFHSDFTTSGFFVLS 2282
Query: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCS 469
+ R +C PP + + + I Y+C G+ LVG A L+C
Sbjct: 2283 YH--AYQLR------VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2334
Query: 470 YS---HWSAPAPQCKALCRKPEL 489
P C+ LC EL
Sbjct: 2335 LGERLQMDGAPPVCQVLCPANEL 2357
Score = 37.0 bits (84), Expect = 0.052
Identities = 91/453 (20%), Positives = 146/453 (32%), Gaps = 85/453 (18%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
+CG P P L TRF G ++Y+C+ GY+ Q LTC ++ +
Sbjct: 177 SCGNP-----GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQ-LTCIANSVNTASWDF 230
Query: 109 IYKRCRHP---GELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH 165
CR G G I + SF ++ + + ++ +
Sbjct: 231 PVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE 290
Query: 166 PLPQCEIVKCKPP-----------PDIRNGR----HSGEENFYAY-GFSVTYSCDPR--F 207
EI +PP P I N H ++ + Y GFS Y F
Sbjct: 291 KYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDF 350
Query: 208 SLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267
G + + C PD E G ++ T+ F C
Sbjct: 351 KSRGFKLFPGKDNSNKFSILNEGGIKTASNLC--PDPGEPENGKRIGSDFSLGSTVQFSC 408
Query: 268 QKGFVLRGSSVIHC----DADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKED--- 320
+ +VL+G+ I C + + W+ P C+ +C + P ++ + P + D
Sbjct: 409 DEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNA 468
Query: 321 --VYVVGTV----------LRYRCHPGYKPTT-------DEPTTV-------------IC 348
V+V+ V + GY T +P TV +
Sbjct: 469 QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528
Query: 349 QKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF--- 405
+ W Q E++ K+N EI + P +Y + FS + RF
Sbjct: 529 MSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTP-LYGIREGDGFSNRDVLRFECQ 587
Query: 406 ---------SAICQGDGTWSPRTPSCGDICNFP 429
S +CQ + WS P IC FP
Sbjct: 588 FGFELIGEKSIVCQENNQWSANIP----ICIFP 616
Score = 37.0 bits (84), Expect = 0.052
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG + G I + G + FSCS G+ L G++ C R V WS PLP+C +
Sbjct: 1078 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-V 1134
Query: 173 VKC 175
+C
Sbjct: 1135 AEC 1137
Score = 36.6 bits (83), Expect = 0.067
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 104 YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLI-GSTTSRCEVQDRGVG 162
YNTF + C PG N + + GS I C EGF G+ T C + D V
Sbjct: 722 YNTFG-HNECPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVM 779
Query: 163 WSHPLPQC 170
WS +P+C
Sbjct: 780 WSGLIPKC 787
Score = 36.6 bits (83), Expect = 0.067
Identities = 65/309 (21%), Positives = 108/309 (34%), Gaps = 57/309 (18%)
Query: 233 TCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSP 291
T +C P + HG +G ++ T+ F C G+ L + C+ + W+
Sbjct: 900 TVNTYSCLDPGIPVHGRR---YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL 956
Query: 292 PACE---------PNSCINLPDIPHASWETYPRP---TKEDVYVVGTVLRYRCHPGYKPT 339
P C+ P+ I P P E YP T G +++ H +
Sbjct: 957 PTCDALCGGDVRGPSGTILSPGYP----EFYPNSLNCTWTVDVTHGKGVQFNFHTFH--L 1010
Query: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRP--ANHCVYFYGDEIS 396
D ++ +N +T P P P +N G R ++ + + G I+
Sbjct: 1011 EDHHDYLLITENGSFTQPLARLTGSDLP-PTINAGLYGNFRAQLRFISDFSISYEGFNIT 1069
Query: 397 FSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDK 456
FS + C+ P P G F I + + + C
Sbjct: 1070 FSEYNLEP----CE-----DPGIPQYGSRIGFNFGIG--------------DTLTFSCSS 1106
Query: 457 GYILVGQAKLSC---SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPEN-----VT 508
GY L G +++ C WSAP P+C A C N + + + + EN +
Sbjct: 1107 GYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYS 1166
Query: 509 IQCDSGYGV 517
IQ +G G+
Sbjct: 1167 IQVQAGKGI 1175
Score = 36.2 bits (82), Expect = 0.088
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGN--RTWYPEVPKC 538
C +P+ + + + D+Y+ + V+ QCD GY + G ITC R W +P C
Sbjct: 1948 CPEPQTPSSGIKIG-DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Score = 35.8 bits (81), Expect = 0.11
Identities = 51/234 (21%), Positives = 84/234 (35%), Gaps = 33/234 (14%)
Query: 320 DVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQH 378
D Y+VG V+ ++C GY T + RW P C A C +G I
Sbjct: 1962 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILS- 2020
Query: 379 RKSRPANH-----CVYFYGDEISFSCH------ETSRFSAICQGDGTWSPRTPSCGDICN 427
P N+ C + I F H T + S + G +
Sbjct: 2021 -PGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSG 2079
Query: 428 FPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKP 487
P+I + + S + + +G+ +V QA Y S P P+
Sbjct: 2080 --PQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA-----YQLQSCPDPR-------- 2124
Query: 488 ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKCE 539
NG V + + + ++ +C GY ++G ++TC +R W +P+CE
Sbjct: 2125 PFRNG--FVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2176
Score = 33.9 bits (76), Expect = 0.44
Identities = 51/230 (22%), Positives = 82/230 (35%), Gaps = 37/230 (16%)
Query: 314 PRPTKEDV-----YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPE 367
PRP + + VG + + C PGY + T + + W P CEALC
Sbjct: 2123 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2182
Query: 368 PKLNNGEITQHRKSRPANH-----CVYFY------GDEISFSCHETSR-FSAICQGDGTW 415
NG I + P + C + G I+F+ +T + I DG
Sbjct: 2183 ITAMNGTI--YSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGP- 2239
Query: 416 SPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSA 475
+P G G+ S YS +I+ + + G LS
Sbjct: 2240 DQNSPQIGQF--------SGNTALESVYS-TSNQILIKFHSDFTTSGFFVLSYH------ 2284
Query: 476 PAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC 525
A Q + P + N + + D++ + + QC G+ +VG +TC
Sbjct: 2285 -AYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTC 2333
Score = 32.7 bits (73), Expect = 0.97
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 13/93 (13%)
Query: 397 FSCHETSRFSAICQGDGTWSP--RTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
FS TS F+ G + ++ SCG+ P + +G ++I Y C
Sbjct: 151 FSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVG------DKIRYSC 204
Query: 455 DKGYILVGQAKLSC-----SYSHWSAPAPQCKA 482
GYIL G +L+C + + W P P C+A
Sbjct: 205 VTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 32.3 bits (72), Expect = 1.3
Identities = 11/40 (27%), Positives = 20/40 (50%)
Query: 499 DQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
D + + + +C G+ ++G +SI C N W +P C
Sbjct: 574 DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 30.8 bits (68), Expect = 3.7
Identities = 11/33 (33%), Positives = 17/33 (51%)
Query: 507 VTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
V+ CDSGY + + + C N W +P C+
Sbjct: 928 VSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 960
Score = 30.4 bits (67), Expect = 4.8
Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 6/67 (8%)
Query: 450 IIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEP 504
++++C+ GYIL G + C S + W+ P C C L + ++ Y EP
Sbjct: 1796 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC-GGILTKRKGTILSPGYPEP 1854
Query: 505 ENVTIQC 511
+ + C
Sbjct: 1855 YDNNLNC 1861
Score = 30.4 bits (67), Expect = 4.8
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 3/36 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
C PPP + A +I + F+ G ++Y CLPG+
Sbjct: 2291 CQPPPPVPNA---EILTEDDEFEIGDIIRYQCLPGF 2323
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 176 bits (447), Expect = 4e-44
Identities = 138/510 (27%), Positives = 213/510 (41%), Gaps = 49/510 (9%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY-VRSHSTQTLTCNSDGEWVYNTF 107
+CG P AP + + T + GT + Y C GY + S T C SDG W +
Sbjct: 2591 SCGIPK-----APTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2645
Query: 108 ---CIYKRCRHPGE--LRNGQVEIK--TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C+ C L +G+ I + + +++ FSC G+ +G + C + +
Sbjct: 2646 TPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC-LPNGT 2704
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
W + P C+I+ C P NG G + +YG + ++CD F L+G A C
Sbjct: 2705 WSWRNERPYCQIISCGELPTPPNGNKIGTQT--SYGSTAIFTCDLGFMLVGSAVRECL-- 2760
Query: 221 NETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVI 279
+ G+W S C C P+ + +G+++ G Y Y+DT+V++C GF L GSSV
Sbjct: 2761 --SSGLWSESETRCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVR 2815
Query: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPT 339
C D W+ P+C P SC H Y R T + + V+ + C+ GY
Sbjct: 2816 ICQQDHNWSGQLPSCVPVSC------GHPGSPIYGR-TSGNGFNFNDVVTFSCNIGY--L 2866
Query: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFS 398
PT CQ N +W+ P C+ + C +P G ++ H + YG + +
Sbjct: 2867 MQGPTKAQCQANRQWSHPPPMCKVVNCSDP----GIPANSKRESKIEHGNFTYGTVVFYD 2922
Query: 399 CHE----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
C+ ICQ +G W P C I P + Y+ F + Y C
Sbjct: 2923 CNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYT-FGSTVHYSC 2981
Query: 455 DKGYILVGQAKLSCSYS-HWSAPAPQCK----ALCRKPELVNGRLSVDKDQYVEPENVTI 509
L+GQ+ +C + HWS P C C P G S + + V
Sbjct: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG-TPGHGSRQESNFRTKSTVRY 3040
Query: 510 QCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
CD+GY + G + TC N +W P+C+
Sbjct: 3041 ACDTGYILHGSEERTCLANGSWTGRQPECK 3070
Score = 164 bits (414), Expect = 3e-40
Identities = 146/551 (26%), Positives = 222/551 (40%), Gaps = 86/551 (15%)
Query: 69 TRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR---NGQVE 125
+ ++ T + ++C PGY ++ C +G W + Y + GEL NG +
Sbjct: 2673 SHYEYKTKVVFSCDPGY-HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-K 2730
Query: 126 IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR 185
I T S+GS F+C GF L+GS C G+ WS +C C P I NG+
Sbjct: 2731 IGTQTSYGSTAIFTCDLGFMLVGSAVREC--LSSGL-WSESETRCLAGHCGIPELIVNGQ 2787
Query: 186 HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVS 245
GE Y Y +V Y C+P F L+G + C ++ W P+C ++C P
Sbjct: 2788 VIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLPSCVPVSCGHPGSP 2841
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDI 305
SG G +N+ D + F C G++++G + C A+ +W+ PP C+ +C + P I
Sbjct: 2842 IYGRTSGNG--FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSD-PGI 2898
Query: 306 PHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALC 364
P S + + GTV+ Y C+PGY + +ICQ N +W P C +
Sbjct: 2899 PANSKRE--SKIEHGNFTYGTVVFYDCNPGY--FLFGSSVLICQPNGQWDKPLPECIMID 2954
Query: 365 CPEPKLNNGEITQHRK-------------------------------SRPANHC----VY 389
C P + + K S HC
Sbjct: 2955 CGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATG 3014
Query: 390 FYGD----------EISFSCHETSRFSA------------ICQGDGTWSPRTPSCGDI-C 426
GD E +F T R++ C +G+W+ R P C + C
Sbjct: 3015 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQC 3074
Query: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-C 484
P A+G + +F +IY C +GYIL G + C+ + WS P C + C
Sbjct: 3075 GNPGTTANGKVFRIDGTTF-SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3133
Query: 485 RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVV--GPQSITCSGNRTWYPEVPKCEWET 542
P + L D YV +NV+ C GY + G + TC+ N TW +P C T
Sbjct: 3134 GDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVT 3192
Query: 543 PEGCEQVLTGK 553
Q+ G+
Sbjct: 3193 CPTPPQISNGR 3203
Score = 161 bits (408), Expect = 1e-39
Identities = 140/518 (27%), Positives = 221/518 (42%), Gaps = 54/518 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107
NC P + + + + F GT + Y C PGY S+ L C +G+W
Sbjct: 2892 NCSDPG-IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS-VLICQPNGQWDKPLPE 2949
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
CI C HPG N + + +FGS + +SC+ L+G ++ C++ WS
Sbjct: 2950 CIMIDCGHPGVPPNAVLSGEK-YTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQ 3005
Query: 168 PQCE---IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
P C C P +G S +E+ + +V Y+CD + L G +C
Sbjct: 3006 PHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN---- 3059
Query: 225 GVWRPSPPTCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
G W P C+ + C P + +G++ G ++ ++++ C +G++L G SV C A
Sbjct: 3060 GSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTA 3117
Query: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343
+ W+ + P C SC + P IP A+ Y D YVVG + Y C PGY +
Sbjct: 3118 NGTWSGTLPNCTIISCGD-PGIP-ANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGS 3170
Query: 344 TTVICQKNLRWTPYQ-GCEALCCP-EPKLNNGEITQHRKSRPANHCVYFYGDEISFSC-- 399
C N W+ C A+ CP P+++NG + + +G IS+ C
Sbjct: 3171 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN---------FDWGFSISYICSP 3221
Query: 400 -HETSRFSAI--CQGDGTWSPRTPSC-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECD 455
+E S F A+ C G+GTWS P C C P A G K+ ++ E+ + C+
Sbjct: 3222 GYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCN 3278
Query: 456 KGYILVGQAKLSC-SYSHWSAPAPQC----KALCRKPELVNGRLSVDKDQYVEPENVTIQ 510
+ILVG + C + WS +P C + C P + + + V
Sbjct: 3279 FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFH 3338
Query: 511 CDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548
C G+ + G + TC + TW P+C P C+Q
Sbjct: 3339 CKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPHSCKQ 3373
Score = 132 bits (331), Expect = 1e-30
Identities = 111/446 (24%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV-GWSHPLPQCE 171
C P +G + +T S + ++C GF L+G +++ C G W P+P C+
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588
Query: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW--RP 229
+ C P NG + Y G VTY C+ + L + +++ G W
Sbjct: 2589 AISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSD--GTWSNHN 2644
Query: 230 SPPTCEKITCRKPD---VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC--DAD 284
P C +TC + + HG G Y YK +VF C G+ G + I C +
Sbjct: 2645 KTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704
Query: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
W P C+ SC LP P+ + + + Y G+ + C G+
Sbjct: 2705 WSWRNERPYCQIISCGELPTPPNGN-----KIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2757
Query: 345 TVICQKNLRWTPYQ-GCEALCCPEPKL-NNGEITQHRKSRPANHCVYFYGDEISFSCHET 402
C + W+ + C A C P+L NG++ Y Y D + + C+
Sbjct: 2758 E--CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN---------YGYRDTVVYQCNPG 2806
Query: 403 SRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457
R ICQ D WS + PSC + C P +G + S + F + + + C+ G
Sbjct: 2807 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG--RTSGNGFNFNDVVTFSCNIG 2864
Query: 458 YILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPEL-VNGR--LSVDKDQYVEPENVTIQCD 512
Y++ G K C + WS P P CK + C P + N + ++ + V C+
Sbjct: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924
Query: 513 SGYGVVGPQSITCSGNRTWYPEVPKC 538
GY + G + C N W +P+C
Sbjct: 2925 PGYFLFGSSVLICQPNGQWDKPLPEC 2950
Score = 119 bits (299), Expect = 6e-27
Identities = 100/361 (27%), Positives = 146/361 (40%), Gaps = 36/361 (9%)
Query: 74 GTTLK----YTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKT 128
GTT Y+C+ GY+ S C ++G W C C PG NG +
Sbjct: 3090 GTTFSSSVIYSCMEGYILS-GPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRYGD 3147
Query: 129 DLSFGSQIEFSCSEGFF--LIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186
D G + + C G+ L GS C + WS +P C V C PP I NGR
Sbjct: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRL 3204
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-S 245
G + +GFS++Y C P + L A ++C G W P C C P + +
Sbjct: 3205 EGTN--FDWGFSISYICSPGYELSFPAVLTCVGN----GTWSGEVPQCLPKFCGDPGIPA 3258
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC-EPN--SCINL 302
G+ G + Y+ + F C F+L GSS C AD W+ S P C EP SC N
Sbjct: 3259 QGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN- 3314
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
P +P + + VG+V+++ C G+ TT C +L W+ Q C
Sbjct: 3315 PGVPR-----HGSQNNTFGFQVGSVVQFHCKKGH--LLQGSTTRTCLPDLTWSGIQPECI 3367
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPS 421
C +P+ P++ Y + F + +C+ D TW+ + P
Sbjct: 3368 PHSCKQPE-TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPI 3425
Query: 422 C 422
C
Sbjct: 3426 C 3426
Score = 106 bits (265), Expect = 5e-23
Identities = 88/294 (29%), Positives = 129/294 (43%), Gaps = 31/294 (10%)
Query: 71 FKTGTTLKYTCLPGYVRS-HSTQTLTCNSDGEW--VYNTFCIYKRCRHPGELRNGQVEIK 127
+ G + Y C PGY + ++ TC +G W V T C C P ++ NG++E
Sbjct: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-CRAVTCPTPPQISNGRLE-G 3206
Query: 128 TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCKPPPDIRNGRH 186
T+ +G I + CS G+ L C G G WS +PQC C P G+
Sbjct: 3207 TNFDWGFSISYICSPGYELSFPAVLTCV----GNGTWSGEVPQCLPKFCGDPGIPAQGKR 3262
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT---CRKPD 243
G+ + Y V++SC+ F L+G ++ C + G W S P C + T C P
Sbjct: 3263 EGKS--FIYQSEVSFSCNFPFILVGSSTRICQAD----GTWSGSSPHCIEPTQTSCENPG 3316
Query: 244 VS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302
V HG + FG + + F C+KG +L+GS+ C D W+ P C P+SC
Sbjct: 3317 VPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSC-KQ 3373
Query: 303 PDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT 355
P+ P HA+ P+ G L Y C PG+ V C+ + WT
Sbjct: 3374 PETPAHANVVGMDLPSH------GYTLIYTCQPGFFLAGGTEHRV-CRSDNTWT 3420
Score = 100 bits (248), Expect = 5e-21
Identities = 94/362 (25%), Positives = 144/362 (39%), Gaps = 45/362 (12%)
Query: 199 VTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIY 257
V ++CD F L+G +S C + W P C+ I+C P ++G +++ Y
Sbjct: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDY 2608
Query: 258 NYKDTIVFKCQKGFVLRGSSVIH--CDADSKW--NPSPPACEPNSC--INLPDIPHASWE 311
+ + C G+ L + C +D W + P C +C IN + H W
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW- 2667
Query: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-----PYQGCEALCCP 366
R Y T + + C PGY P ++ C N W+ PY C+ + C
Sbjct: 2668 ---RIVNGSHYEYKTKVVFSCDPGYHGL--GPASIECLPNGTWSWRNERPY--CQIISCG 2720
Query: 367 E-PKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF--SAI--CQGDGTWSPRTPS 421
E P NG + S YG F+C SA+ C G WS
Sbjct: 2721 ELPTPPNGNKIGTQTS---------YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETR 2771
Query: 422 C-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQ 479
C C P I +G +Y +++ ++Y+C+ G+ L+G + C H WS P
Sbjct: 2772 CLAGHCGIPELIVNGQV-IGENYG-YRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829
Query: 480 CKAL-CRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537
C + C P + GR S + + + VT C+ GY + GP C NR W P
Sbjct: 2830 CVPVSCGHPGSPIYGRTSGNGFNF--NDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPM 2887
Query: 538 CE 539
C+
Sbjct: 2888 CK 2889
Score = 98.2 bits (243), Expect = 2e-20
Identities = 77/261 (29%), Positives = 113/261 (43%), Gaps = 23/261 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FC 108
C PP +S L T F G ++ Y C PGY S LTC +G W C
Sbjct: 3193 CPTPPQISNGR-----LEGTNFDWGFSISYICSPGYELSFPA-VLTCVGNGTWSGEVPQC 3246
Query: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168
+ K C PG G+ E K+ + + S++ FSC+ F L+GS+T C+ WS P
Sbjct: 3247 LPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3302
Query: 169 QC---EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225
C C+ P R+G + F G V + C L G + +C +
Sbjct: 3303 HCIEPTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDL---- 3357
Query: 226 VWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIH-CDA 283
W P C +C++P+ +H +V P + Y T+++ CQ GF L G + C +
Sbjct: 3358 TWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRS 3415
Query: 284 DSKWNPSPPACEPNSCINLPD 304
D+ W P CE S I + D
Sbjct: 3416 DNTWTGKVPICEAGSKILVKD 3436
Score = 59.7 bits (143), Expect = 7e-09
Identities = 107/483 (22%), Positives = 161/483 (33%), Gaps = 114/483 (23%)
Query: 82 LPGYVRSHS-TQTLTCNSDGEWVYNTFCI-YKR-----CRHPGELRNGQVEIKTDLSFGS 134
LP + S S T L SDG Y F + YK C PG + NG + D GS
Sbjct: 1623 LPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNG-TRLGMDYKLGS 1681
Query: 135 QIEFSCSEGFFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGE--EN 191
+ + C G+ L G +T C + D G GW+ LP C P R+ G
Sbjct: 1682 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS-----CHAPCGSRSTGSEGTVLSP 1736
Query: 192 FYAYGFSVTYSC---------------------------------DPRFSLLGHASIS-- 216
Y +SV ++C + SLL S S
Sbjct: 1737 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHS 1796
Query: 217 -----------CTVENETIG---------VWRPSPPTCEKITCRKPDVSHGEMVSGFGPI 256
T+ ++G V++ P T P+ G + G
Sbjct: 1797 GESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRI---GNE 1853
Query: 257 YNYKDTIVFKCQKGFVLRGSSVIHCD----ADSKWNPSPPAC-EPNSCINLPDIPHASWE 311
+ +++F C G++L GS I C+ + ++WN S P C P I
Sbjct: 1854 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1913
Query: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQ-----KNLRWTPYQGCEALCCP 366
YP P ++ V +K T E + Q W +
Sbjct: 1914 GYPEPYDNNLNCV-----------WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1962
Query: 367 EPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGD 424
P+L +G H + +N+ + +IS S D P+TPS G
Sbjct: 1963 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG- 2021
Query: 425 ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC---SYSHWSAPAPQCK 481
K Y + + ++CD+GY L G + ++C W+ P P C
Sbjct: 2022 ------------IKIGDRY-MVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2068
Query: 482 ALC 484
A C
Sbjct: 2069 AQC 2071
Score = 56.2 bits (134), Expect = 8e-08
Identities = 60/241 (24%), Positives = 95/241 (39%), Gaps = 35/241 (14%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY + + + C P RNG V I D + G I F C G+ LIG++ C +
Sbjct: 2175 VYQAYQL-QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRN 2231
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTY-SCDPRFSLLGHASISCTVEN 221
W+HPLP+CE + C NG Y+ G+ Y + F L+ + N
Sbjct: 2232 WNHPLPRCEAL-CGGNITAMNG------TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYIN 2284
Query: 222 ETIGVWRPSPPTCEKITC------RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275
T+ + P + IT P + + +Y+ + I+ K F G
Sbjct: 2285 FTV---LQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2341
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
V+ A PP PN+ I T++D + +G ++RY+C PG
Sbjct: 2342 FFVLSYHAYQLRVCQPPPPVPNAEI---------------LTEDDEFEIGDIIRYQCLPG 2386
Query: 336 Y 336
+
Sbjct: 2387 F 2387
Score = 50.4 bits (119), Expect = 5e-06
Identities = 112/479 (23%), Positives = 168/479 (35%), Gaps = 108/479 (22%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY +F + C PG + G GS I + C+ G+ L GS+ +C +R
Sbjct: 1305 VYTSFEL-SHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR-A 1362
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEEN------FYAYGFSVTYSC------DP-RFSL 209
W +PLP C I +C GR GE + Y + + C DP
Sbjct: 1363 WDYPLPSC-IAEC-------GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVS 1414
Query: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYK----DTIVF 265
L + ++ + VW PP + + ++S + G N DT +
Sbjct: 1415 LQFLAFDTEASHDILRVW-DGPPENDMLL---KEISGSLIPEGIHSTLNIVTIQFDTDFY 1470
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVG 325
+ GF ++ SS + AC P +P D G
Sbjct: 1471 ISKSGFAIQFSSSV-----------ATACRD------PGVPMNG------TRNGDGREPG 1507
Query: 326 TVLRYRCHPGYKPTTDEPTTVICQKN-LRWTPYQG-CEALCCPEPKLNNGEITQ------ 377
+ ++C PGY+ +E T I +N W P C A C ++G I
Sbjct: 1508 DTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHP 1567
Query: 378 HRKSRPANHCVYFYGDE------ISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPK 431
+ SR + + D ISFS F I G + SP S D P +
Sbjct: 1568 YPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD-SKLPER 1626
Query: 432 I------AHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCR 485
I H ++ S S+ G+ L +AKL + C
Sbjct: 1627 IESSSNTMHLAFRSDGSVSY----------TGFHLEYKAKL--------------RESCF 1662
Query: 486 KP-ELVNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC----SGNRTWYPEVPKC 538
P ++NG RL +D Y VT CD+GY + G ++TC G W +P C
Sbjct: 1663 DPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Score = 47.0 bits (110), Expect = 5e-05
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQCE 171
C PGE NG+ I +D S GS ++FSC E + L G+ + C+ + + WS P C+
Sbjct: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504
Query: 172 IVKC 175
+ C
Sbjct: 505 VKTC 508
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/232 (20%), Positives = 94/232 (40%), Gaps = 35/232 (15%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQ--H 378
+ +G+ + + C GY+ + +EP ++C+KN W+ P C+ALC + + +G I +
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEP--LLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGY 1043
Query: 379 RKSRPAN-HCVYF----YGDEISFSCH-----ETSRFSAICQGDGTWSPRTPSCGDICNF 428
+ P + +C + +G + F+ H + + I + P G +
Sbjct: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGS--DL 1101
Query: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPE 488
PP I G Y F+ ++ + D G + ++S ++ + + +
Sbjct: 1102 PPTINAGLYGN------FRAQLRFISDFSISYEG---FNITFSEYNLEPCEDPGIPQYGS 1152
Query: 489 LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKC 538
+ + + +T C SGY + G I C G R W +P+C
Sbjct: 1153 RIGFNFGIG-------DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197
Score = 43.1 bits (100), Expect = 7e-04
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P + NG+ G + ++ G +V +SCD + L G SI+C E W P C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 235 EKITC 239
+ TC
Sbjct: 504 KVKTC 508
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/333 (22%), Positives = 114/333 (34%), Gaps = 92/333 (27%)
Query: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC-DADSK--WNPSPPACE 295
CR P V +G G DT+VF+C G+ L+G I C +++ W PSPP C
Sbjct: 1488 CRDPGVPMNGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545
Query: 296 PNSCINL---------PDIPHASWETYPRPTKEDV---------YVVGTV-LRYRCHPGY 336
NL P+ PH P P D YV+ + + P Y
Sbjct: 1546 APCGGNLTGSSGFILSPNFPH------PYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1599
Query: 337 K-------PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVY 389
P ++ P Q + PE ++ + T H R ++ V
Sbjct: 1600 DFLYIYDGPDSNSPLIGSFQDSK------------LPE-RIESSSNTMHLAFR-SDGSVS 1645
Query: 390 FYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHG-----HYKQSSSYS 444
+ G + + + SC D P I +G YK S+
Sbjct: 1646 YTGFHLEYK-----------------AKLRESCFD----PGNIMNGTRLGMDYKLGST-- 1682
Query: 445 FFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPAPQCKALCRKPELVNGRLSVDKD 499
+ Y CD GY+L G + L+C W+ P C A C +V
Sbjct: 1683 -----VTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS-RSTGSEGTVLSP 1736
Query: 500 QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
Y P+N ++ + Y + P+ G ++
Sbjct: 1737 NY--PKNYSVGHNCVYSIAVPKEFVVFGQFVFF 1767
Score = 42.0 bits (97), Expect = 0.002
Identities = 57/237 (24%), Positives = 77/237 (32%), Gaps = 64/237 (27%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG +G+ D S GS + FSC G+ L CE + WSHPLP C+
Sbjct: 970 CLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1025
Query: 173 VKCKPPPDIRNGRHS----GEENFYAYGFSVTYSCD-----------PRFSLLGHASISC 217
+ C D+R + G FY + T++ D F L H
Sbjct: 1026 L-C--GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLL 1082
Query: 218 TVENETIG------VWRPSPPTCE------------------------KIT--------C 239
EN + PPT IT C
Sbjct: 1083 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142
Query: 240 RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK--WNPSPPAC 294
P + GF + DT+ F C G+ L G+S I C + W+ P C
Sbjct: 1143 EDPGIPQYGSRIGFN--FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197
Score = 40.4 bits (93), Expect = 0.005
Identities = 16/40 (40%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Query: 448 EEIIYECDKGYILVGQAKLSCSYS---HWSAPAPQCKALC 484
+ I +EC GY L+G + L+C + +W+ P P+C+ALC
Sbjct: 2204 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2243
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C+PPP + N E++ + G + Y C P F+L+G+A ++C + +PP C
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERL--QMDGAPPVC 2412
Query: 235 E 235
+
Sbjct: 2413 Q 2413
Score = 38.5 bits (88), Expect = 0.018
Identities = 62/263 (23%), Positives = 87/263 (33%), Gaps = 65/263 (24%)
Query: 254 GPIYNYKDTIVFKCQKGFVLRGSSVIHC--DADSKWNPSPPACEP---------NSCINL 302
G + TI F+C G+ L G+S + C WN P CE N I
Sbjct: 2197 GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYS 2256
Query: 303 PDIPHASWETYPR----------PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL 352
P P + YP P +Y+ TVL+ +P D T
Sbjct: 2257 PGYP----DEYPNFQDCFWLVRVPPGNGIYINFTVLQT------EPIYDFITV------- 2299
Query: 353 RWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE---TSRFSAIC 409
+ G P N+ +I Q A VY ++I H TS F +
Sbjct: 2300 ----WDG--------PDQNSPQIGQF-SGNTALESVYSTSNQILIKFHSDFTTSGFFVLS 2346
Query: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCS 469
+ R +C PP + + + I Y+C G+ LVG A L+C
Sbjct: 2347 YH--AYQLR------VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2398
Query: 470 YS---HWSAPAPQCKALCRKPEL 489
P C+ LC EL
Sbjct: 2399 LGERLQMDGAPPVCQVLCPANEL 2421
Score = 37.0 bits (84), Expect = 0.052
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG + G I + G + FSCS G+ L G++ C R V WS PLP+C +
Sbjct: 1142 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-V 1198
Query: 173 VKC 175
+C
Sbjct: 1199 AEC 1201
Score = 36.6 bits (83), Expect = 0.067
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Query: 235 EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
EK +C P + G G ++ +D + F+CQ GF L G I C +++W+ + P C
Sbjct: 620 EKESCGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677
Score = 36.6 bits (83), Expect = 0.067
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 104 YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLI-GSTTSRCEVQDRGVG 162
YNTF + C PG N + + GS I C EGF G+ T C + D V
Sbjct: 786 YNTFG-HNECPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVM 843
Query: 163 WSHPLPQC 170
WS +P+C
Sbjct: 844 WSGLIPKC 851
Score = 36.6 bits (83), Expect = 0.067
Identities = 65/309 (21%), Positives = 108/309 (34%), Gaps = 57/309 (18%)
Query: 233 TCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSP 291
T +C P + HG +G ++ T+ F C G+ L + C+ + W+
Sbjct: 964 TVNTYSCLDPGIPVHGRR---YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL 1020
Query: 292 PACE---------PNSCINLPDIPHASWETYPRP---TKEDVYVVGTVLRYRCHPGYKPT 339
P C+ P+ I P P E YP T G +++ H +
Sbjct: 1021 PTCDALCGGDVRGPSGTILSPGYP----EFYPNSLNCTWTVDVTHGKGVQFNFHTFH--L 1074
Query: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRP--ANHCVYFYGDEIS 396
D ++ +N +T P P P +N G R ++ + + G I+
Sbjct: 1075 EDHHDYLLITENGSFTQPLARLTGSDLP-PTINAGLYGNFRAQLRFISDFSISYEGFNIT 1133
Query: 397 FSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDK 456
FS + C+ P P G F I + + + C
Sbjct: 1134 FSEYNLEP----CE-----DPGIPQYGSRIGFNFGIG--------------DTLTFSCSS 1170
Query: 457 GYILVGQAKLSC---SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPEN-----VT 508
GY L G +++ C WSAP P+C A C N + + + + EN +
Sbjct: 1171 GYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYS 1230
Query: 509 IQCDSGYGV 517
IQ +G G+
Sbjct: 1231 IQVQAGKGI 1239
Score = 36.2 bits (82), Expect = 0.088
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGN--RTWYPEVPKC 538
C +P+ + + + D+Y+ + V+ QCD GY + G ITC R W +P C
Sbjct: 2012 CPEPQTPSSGIKIG-DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Score = 35.8 bits (81), Expect = 0.11
Identities = 51/234 (21%), Positives = 84/234 (35%), Gaps = 33/234 (14%)
Query: 320 DVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQH 378
D Y+VG V+ ++C GY T + RW P C A C +G I
Sbjct: 2026 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILS- 2084
Query: 379 RKSRPANH-----CVYFYGDEISFSCH------ETSRFSAICQGDGTWSPRTPSCGDICN 427
P N+ C + I F H T + S + G +
Sbjct: 2085 -PGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSG 2143
Query: 428 FPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKP 487
P+I + + S + + +G+ +V QA Y S P P+
Sbjct: 2144 --PQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA-----YQLQSCPDPR-------- 2188
Query: 488 ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKCE 539
NG V + + + ++ +C GY ++G ++TC +R W +P+CE
Sbjct: 2189 PFRNG--FVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2240
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/239 (21%), Positives = 83/239 (34%), Gaps = 56/239 (23%)
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC----DADSKWNPSPPACEPN 297
PD E G ++ T+ F C + +VL+G+ I C + + W+ P C+
Sbjct: 447 PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 506
Query: 298 SCINLPDIPHASWETYPRPTKED-----VYVVGTV----------LRYRCHPGYKPTT-- 340
+C + P ++ + P + D V+V+ V + GY T
Sbjct: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566
Query: 341 -----DEPTTV-------------ICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSR 382
+P TV + + W Q E++ K+N EI +
Sbjct: 567 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGD 626
Query: 383 PANHCVYFYGDEISFSCHETSRF------------SAICQGDGTWSPRTPSCGDICNFP 429
P +Y + FS + RF S +CQ + WS P IC FP
Sbjct: 627 PGTP-LYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP----ICIFP 680
Score = 33.9 bits (76), Expect = 0.44
Identities = 51/230 (22%), Positives = 82/230 (35%), Gaps = 37/230 (16%)
Query: 314 PRPTKEDV-----YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPE 367
PRP + + VG + + C PGY + T + + W P CEALC
Sbjct: 2187 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2246
Query: 368 PKLNNGEITQHRKSRPANH-----CVYFY------GDEISFSCHETSR-FSAICQGDGTW 415
NG I + P + C + G I+F+ +T + I DG
Sbjct: 2247 ITAMNGTI--YSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGP- 2303
Query: 416 SPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSA 475
+P G G+ S YS +I+ + + G LS
Sbjct: 2304 DQNSPQIGQF--------SGNTALESVYS-TSNQILIKFHSDFTTSGFFVLSYH------ 2348
Query: 476 PAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC 525
A Q + P + N + + D++ + + QC G+ +VG +TC
Sbjct: 2349 -AYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTC 2397
Score = 32.7 bits (73), Expect = 0.97
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 13/93 (13%)
Query: 397 FSCHETSRFSAICQGDGTWSP--RTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
FS TS F+ G + ++ SCG+ P + +G ++I Y C
Sbjct: 111 FSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVG------DKIRYSC 164
Query: 455 DKGYILVGQAKLSC-----SYSHWSAPAPQCKA 482
GYIL G +L+C + + W P P C+A
Sbjct: 165 VTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Score = 32.3 bits (72), Expect = 1.3
Identities = 11/40 (27%), Positives = 20/40 (50%)
Query: 499 DQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
D + + + +C G+ ++G +SI C N W +P C
Sbjct: 638 DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677
Score = 30.8 bits (68), Expect = 3.7
Identities = 11/33 (33%), Positives = 17/33 (51%)
Query: 507 VTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
V+ CDSGY + + + C N W +P C+
Sbjct: 992 VSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1024
Score = 30.4 bits (67), Expect = 4.8
Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 6/67 (8%)
Query: 450 IIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEP 504
++++C+ GYIL G + C S + W+ P C C L + ++ Y EP
Sbjct: 1860 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC-GGILTKRKGTILSPGYPEP 1918
Query: 505 ENVTIQC 511
+ + C
Sbjct: 1919 YDNNLNC 1925
Score = 30.4 bits (67), Expect = 4.8
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 3/36 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
C PPP + A +I + F+ G ++Y CLPG+
Sbjct: 2355 CQPPPPVPNA---EILTEDDEFEIGDIIRYQCLPGF 2387
Score = 30.0 bits (66), Expect = 6.3
Identities = 17/48 (35%), Positives = 23/48 (47%), Gaps = 6/48 (12%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTC 96
+CG P P L TRF G ++Y+C+ GY+ Q LTC
Sbjct: 137 SCGNP-----GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQ-LTC 178
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 176 bits (447), Expect = 4e-44
Identities = 138/510 (27%), Positives = 213/510 (41%), Gaps = 49/510 (9%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY-VRSHSTQTLTCNSDGEWVYNTF 107
+CG P AP + + T + GT + Y C GY + S T C SDG W +
Sbjct: 2631 SCGIPK-----APTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2685
Query: 108 ---CIYKRCRHPGE--LRNGQVEIK--TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
C+ C L +G+ I + + +++ FSC G+ +G + C + +
Sbjct: 2686 TPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC-LPNGT 2744
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
W + P C+I+ C P NG G + +YG + ++CD F L+G A C
Sbjct: 2745 WSWRNERPYCQIISCGELPTPPNGNKIGTQT--SYGSTAIFTCDLGFMLVGSAVRECL-- 2800
Query: 221 NETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVI 279
+ G+W S C C P+ + +G+++ G Y Y+DT+V++C GF L GSSV
Sbjct: 2801 --SSGLWSESETRCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVR 2855
Query: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPT 339
C D W+ P+C P SC H Y R T + + V+ + C+ GY
Sbjct: 2856 ICQQDHNWSGQLPSCVPVSC------GHPGSPIYGR-TSGNGFNFNDVVTFSCNIGY--L 2906
Query: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFS 398
PT CQ N +W+ P C+ + C +P G ++ H + YG + +
Sbjct: 2907 MQGPTKAQCQANRQWSHPPPMCKVVNCSDP----GIPANSKRESKIEHGNFTYGTVVFYD 2962
Query: 399 CHE----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
C+ ICQ +G W P C I P + Y+ F + Y C
Sbjct: 2963 CNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYT-FGSTVHYSC 3021
Query: 455 DKGYILVGQAKLSCSYS-HWSAPAPQCK----ALCRKPELVNGRLSVDKDQYVEPENVTI 509
L+GQ+ +C + HWS P C C P G S + + V
Sbjct: 3022 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG-TPGHGSRQESNFRTKSTVRY 3080
Query: 510 QCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
CD+GY + G + TC N +W P+C+
Sbjct: 3081 ACDTGYILHGSEERTCLANGSWTGRQPECK 3110
Score = 164 bits (414), Expect = 3e-40
Identities = 146/551 (26%), Positives = 222/551 (40%), Gaps = 86/551 (15%)
Query: 69 TRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR---NGQVE 125
+ ++ T + ++C PGY ++ C +G W + Y + GEL NG +
Sbjct: 2713 SHYEYKTKVVFSCDPGY-HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-K 2770
Query: 126 IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR 185
I T S+GS F+C GF L+GS C G+ WS +C C P I NG+
Sbjct: 2771 IGTQTSYGSTAIFTCDLGFMLVGSAVREC--LSSGL-WSESETRCLAGHCGIPELIVNGQ 2827
Query: 186 HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVS 245
GE Y Y +V Y C+P F L+G + C ++ W P+C ++C P
Sbjct: 2828 VIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLPSCVPVSCGHPGSP 2881
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDI 305
SG G +N+ D + F C G++++G + C A+ +W+ PP C+ +C + P I
Sbjct: 2882 IYGRTSGNG--FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSD-PGI 2938
Query: 306 PHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALC 364
P S + + GTV+ Y C+PGY + +ICQ N +W P C +
Sbjct: 2939 PANSKRE--SKIEHGNFTYGTVVFYDCNPGY--FLFGSSVLICQPNGQWDKPLPECIMID 2994
Query: 365 CPEPKLNNGEITQHRK-------------------------------SRPANHC----VY 389
C P + + K S HC
Sbjct: 2995 CGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATG 3054
Query: 390 FYGD----------EISFSCHETSRFSA------------ICQGDGTWSPRTPSCGDI-C 426
GD E +F T R++ C +G+W+ R P C + C
Sbjct: 3055 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQC 3114
Query: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-C 484
P A+G + +F +IY C +GYIL G + C+ + WS P C + C
Sbjct: 3115 GNPGTTANGKVFRIDGTTF-SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3173
Query: 485 RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVV--GPQSITCSGNRTWYPEVPKCEWET 542
P + L D YV +NV+ C GY + G + TC+ N TW +P C T
Sbjct: 3174 GDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVT 3232
Query: 543 PEGCEQVLTGK 553
Q+ G+
Sbjct: 3233 CPTPPQISNGR 3243
Score = 161 bits (408), Expect = 1e-39
Identities = 140/518 (27%), Positives = 221/518 (42%), Gaps = 54/518 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107
NC P + + + + F GT + Y C PGY S+ L C +G+W
Sbjct: 2932 NCSDPG-IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS-VLICQPNGQWDKPLPE 2989
Query: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167
CI C HPG N + + +FGS + +SC+ L+G ++ C++ WS
Sbjct: 2990 CIMIDCGHPGVPPNAVLSGEK-YTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQ 3045
Query: 168 PQCE---IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
P C C P +G S +E+ + +V Y+CD + L G +C
Sbjct: 3046 PHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN---- 3099
Query: 225 GVWRPSPPTCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
G W P C+ + C P + +G++ G ++ ++++ C +G++L G SV C A
Sbjct: 3100 GSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTA 3157
Query: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343
+ W+ + P C SC + P IP A+ Y D YVVG + Y C PGY +
Sbjct: 3158 NGTWSGTLPNCTIISCGD-PGIP-ANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGS 3210
Query: 344 TTVICQKNLRWTPYQ-GCEALCCP-EPKLNNGEITQHRKSRPANHCVYFYGDEISFSC-- 399
C N W+ C A+ CP P+++NG + + +G IS+ C
Sbjct: 3211 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN---------FDWGFSISYICSP 3261
Query: 400 -HETSRFSAI--CQGDGTWSPRTPSC-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECD 455
+E S F A+ C G+GTWS P C C P A G K+ ++ E+ + C+
Sbjct: 3262 GYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCN 3318
Query: 456 KGYILVGQAKLSC-SYSHWSAPAPQC----KALCRKPELVNGRLSVDKDQYVEPENVTIQ 510
+ILVG + C + WS +P C + C P + + + V
Sbjct: 3319 FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFH 3378
Query: 511 CDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548
C G+ + G + TC + TW P+C P C+Q
Sbjct: 3379 CKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPHSCKQ 3413
Score = 132 bits (331), Expect = 1e-30
Identities = 111/446 (24%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV-GWSHPLPQCE 171
C P +G + +T S + ++C GF L+G +++ C G W P+P C+
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628
Query: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW--RP 229
+ C P NG + Y G VTY C+ + L + +++ G W
Sbjct: 2629 AISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSD--GTWSNHN 2684
Query: 230 SPPTCEKITCRKPD---VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC--DAD 284
P C +TC + + HG G Y YK +VF C G+ G + I C +
Sbjct: 2685 KTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2744
Query: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
W P C+ SC LP P+ + + + Y G+ + C G+
Sbjct: 2745 WSWRNERPYCQIISCGELPTPPNGN-----KIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2797
Query: 345 TVICQKNLRWTPYQ-GCEALCCPEPKL-NNGEITQHRKSRPANHCVYFYGDEISFSCHET 402
C + W+ + C A C P+L NG++ Y Y D + + C+
Sbjct: 2798 E--CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN---------YGYRDTVVYQCNPG 2846
Query: 403 SRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457
R ICQ D WS + PSC + C P +G + S + F + + + C+ G
Sbjct: 2847 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG--RTSGNGFNFNDVVTFSCNIG 2904
Query: 458 YILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPEL-VNGR--LSVDKDQYVEPENVTIQCD 512
Y++ G K C + WS P P CK + C P + N + ++ + V C+
Sbjct: 2905 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2964
Query: 513 SGYGVVGPQSITCSGNRTWYPEVPKC 538
GY + G + C N W +P+C
Sbjct: 2965 PGYFLFGSSVLICQPNGQWDKPLPEC 2990
Score = 119 bits (299), Expect = 6e-27
Identities = 100/361 (27%), Positives = 146/361 (40%), Gaps = 36/361 (9%)
Query: 74 GTTLK----YTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKT 128
GTT Y+C+ GY+ S C ++G W C C PG NG +
Sbjct: 3130 GTTFSSSVIYSCMEGYILS-GPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG-LRYGD 3187
Query: 129 DLSFGSQIEFSCSEGFF--LIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186
D G + + C G+ L GS C + WS +P C V C PP I NGR
Sbjct: 3188 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRL 3244
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-S 245
G + +GFS++Y C P + L A ++C G W P C C P + +
Sbjct: 3245 EGTN--FDWGFSISYICSPGYELSFPAVLTCVGN----GTWSGEVPQCLPKFCGDPGIPA 3298
Query: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC-EPN--SCINL 302
G+ G + Y+ + F C F+L GSS C AD W+ S P C EP SC N
Sbjct: 3299 QGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN- 3354
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
P +P + + VG+V+++ C G+ TT C +L W+ Q C
Sbjct: 3355 PGVPR-----HGSQNNTFGFQVGSVVQFHCKKGH--LLQGSTTRTCLPDLTWSGIQPECI 3407
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPS 421
C +P+ P++ Y + F + +C+ D TW+ + P
Sbjct: 3408 PHSCKQPE-TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPI 3465
Query: 422 C 422
C
Sbjct: 3466 C 3466
Score = 106 bits (265), Expect = 5e-23
Identities = 88/294 (29%), Positives = 129/294 (43%), Gaps = 31/294 (10%)
Query: 71 FKTGTTLKYTCLPGYVRS-HSTQTLTCNSDGEW--VYNTFCIYKRCRHPGELRNGQVEIK 127
+ G + Y C PGY + ++ TC +G W V T C C P ++ NG++E
Sbjct: 3189 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-CRAVTCPTPPQISNGRLE-G 3246
Query: 128 TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQCEIVKCKPPPDIRNGRH 186
T+ +G I + CS G+ L C G G WS +PQC C P G+
Sbjct: 3247 TNFDWGFSISYICSPGYELSFPAVLTCV----GNGTWSGEVPQCLPKFCGDPGIPAQGKR 3302
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT---CRKPD 243
G+ + Y V++SC+ F L+G ++ C + G W S P C + T C P
Sbjct: 3303 EGKS--FIYQSEVSFSCNFPFILVGSSTRICQAD----GTWSGSSPHCIEPTQTSCENPG 3356
Query: 244 VS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302
V HG + FG + + F C+KG +L+GS+ C D W+ P C P+SC
Sbjct: 3357 VPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSC-KQ 3413
Query: 303 PDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT 355
P+ P HA+ P+ G L Y C PG+ V C+ + WT
Sbjct: 3414 PETPAHANVVGMDLPSH------GYTLIYTCQPGFFLAGGTEHRV-CRSDNTWT 3460
Score = 100 bits (248), Expect = 5e-21
Identities = 94/362 (25%), Positives = 144/362 (39%), Gaps = 45/362 (12%)
Query: 199 VTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIY 257
V ++CD F L+G +S C + W P C+ I+C P ++G +++ Y
Sbjct: 2592 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDY 2648
Query: 258 NYKDTIVFKCQKGFVLRGSSVIH--CDADSKW--NPSPPACEPNSC--INLPDIPHASWE 311
+ + C G+ L + C +D W + P C +C IN + H W
Sbjct: 2649 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW- 2707
Query: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-----PYQGCEALCCP 366
R Y T + + C PGY P ++ C N W+ PY C+ + C
Sbjct: 2708 ---RIVNGSHYEYKTKVVFSCDPGYHGL--GPASIECLPNGTWSWRNERPY--CQIISCG 2760
Query: 367 E-PKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF--SAI--CQGDGTWSPRTPS 421
E P NG + S YG F+C SA+ C G WS
Sbjct: 2761 ELPTPPNGNKIGTQTS---------YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETR 2811
Query: 422 C-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQ 479
C C P I +G +Y +++ ++Y+C+ G+ L+G + C H WS P
Sbjct: 2812 CLAGHCGIPELIVNGQV-IGENYG-YRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2869
Query: 480 CKAL-CRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537
C + C P + GR S + + + VT C+ GY + GP C NR W P
Sbjct: 2870 CVPVSCGHPGSPIYGRTSGNGFNF--NDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPM 2927
Query: 538 CE 539
C+
Sbjct: 2928 CK 2929
Score = 98.2 bits (243), Expect = 2e-20
Identities = 77/261 (29%), Positives = 113/261 (43%), Gaps = 23/261 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FC 108
C PP +S L T F G ++ Y C PGY S LTC +G W C
Sbjct: 3233 CPTPPQISNGR-----LEGTNFDWGFSISYICSPGYELSFPA-VLTCVGNGTWSGEVPQC 3286
Query: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168
+ K C PG G+ E K+ + + S++ FSC+ F L+GS+T C+ WS P
Sbjct: 3287 LPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3342
Query: 169 QC---EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225
C C+ P R+G + F G V + C L G + +C +
Sbjct: 3343 HCIEPTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDL---- 3397
Query: 226 VWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIH-CDA 283
W P C +C++P+ +H +V P + Y T+++ CQ GF L G + C +
Sbjct: 3398 TWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRS 3455
Query: 284 DSKWNPSPPACEPNSCINLPD 304
D+ W P CE S I + D
Sbjct: 3456 DNTWTGKVPICEAGSKILVKD 3476
Score = 59.7 bits (143), Expect = 7e-09
Identities = 107/483 (22%), Positives = 161/483 (33%), Gaps = 114/483 (23%)
Query: 82 LPGYVRSHS-TQTLTCNSDGEWVYNTFCI-YKR-----CRHPGELRNGQVEIKTDLSFGS 134
LP + S S T L SDG Y F + YK C PG + NG + D GS
Sbjct: 1663 LPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNG-TRLGMDYKLGS 1721
Query: 135 QIEFSCSEGFFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGE--EN 191
+ + C G+ L G +T C + D G GW+ LP C P R+ G
Sbjct: 1722 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS-----CHAPCGSRSTGSEGTVLSP 1776
Query: 192 FYAYGFSVTYSC---------------------------------DPRFSLLGHASIS-- 216
Y +SV ++C + SLL S S
Sbjct: 1777 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHS 1836
Query: 217 -----------CTVENETIG---------VWRPSPPTCEKITCRKPDVSHGEMVSGFGPI 256
T+ ++G V++ P T P+ G + G
Sbjct: 1837 GESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRI---GNE 1893
Query: 257 YNYKDTIVFKCQKGFVLRGSSVIHCD----ADSKWNPSPPAC-EPNSCINLPDIPHASWE 311
+ +++F C G++L GS I C+ + ++WN S P C P I
Sbjct: 1894 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1953
Query: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQ-----KNLRWTPYQGCEALCCP 366
YP P ++ V +K T E + Q W +
Sbjct: 1954 GYPEPYDNNLNCV-----------WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 2002
Query: 367 EPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGD 424
P+L +G H + +N+ + +IS S D P+TPS G
Sbjct: 2003 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG- 2061
Query: 425 ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC---SYSHWSAPAPQCK 481
K Y + + ++CD+GY L G + ++C W+ P P C
Sbjct: 2062 ------------IKIGDRY-MVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2108
Query: 482 ALC 484
A C
Sbjct: 2109 AQC 2111
Score = 56.2 bits (134), Expect = 8e-08
Identities = 60/241 (24%), Positives = 95/241 (39%), Gaps = 35/241 (14%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY + + + C P RNG V I D + G I F C G+ LIG++ C +
Sbjct: 2215 VYQAYQL-QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRN 2271
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTY-SCDPRFSLLGHASISCTVEN 221
W+HPLP+CE + C NG Y+ G+ Y + F L+ + N
Sbjct: 2272 WNHPLPRCEAL-CGGNITAMNG------TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYIN 2324
Query: 222 ETIGVWRPSPPTCEKITC------RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275
T+ + P + IT P + + +Y+ + I+ K F G
Sbjct: 2325 FTV---LQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2381
Query: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
V+ A PP PN+ I T++D + +G ++RY+C PG
Sbjct: 2382 FFVLSYHAYQLRVCQPPPPVPNAEI---------------LTEDDEFEIGDIIRYQCLPG 2426
Query: 336 Y 336
+
Sbjct: 2427 F 2427
Score = 50.4 bits (119), Expect = 5e-06
Identities = 112/479 (23%), Positives = 168/479 (35%), Gaps = 108/479 (22%)
Query: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
VY +F + C PG + G GS I + C+ G+ L GS+ +C +R
Sbjct: 1345 VYTSFEL-SHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR-A 1402
Query: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEEN------FYAYGFSVTYSC------DP-RFSL 209
W +PLP C I +C GR GE + Y + + C DP
Sbjct: 1403 WDYPLPSC-IAEC-------GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVS 1454
Query: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYK----DTIVF 265
L + ++ + VW PP + + ++S + G N DT +
Sbjct: 1455 LQFLAFDTEASHDILRVW-DGPPENDMLL---KEISGSLIPEGIHSTLNIVTIQFDTDFY 1510
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVG 325
+ GF ++ SS + AC P +P D G
Sbjct: 1511 ISKSGFAIQFSSSV-----------ATACRD------PGVPMNG------TRNGDGREPG 1547
Query: 326 TVLRYRCHPGYKPTTDEPTTVICQKN-LRWTPYQG-CEALCCPEPKLNNGEITQ------ 377
+ ++C PGY+ +E T I +N W P C A C ++G I
Sbjct: 1548 DTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHP 1607
Query: 378 HRKSRPANHCVYFYGDE------ISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPK 431
+ SR + + D ISFS F I G + SP S D P +
Sbjct: 1608 YPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD-SKLPER 1666
Query: 432 I------AHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCR 485
I H ++ S S+ G+ L +AKL + C
Sbjct: 1667 IESSSNTMHLAFRSDGSVSY----------TGFHLEYKAKL--------------RESCF 1702
Query: 486 KP-ELVNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC----SGNRTWYPEVPKC 538
P ++NG RL +D Y VT CD+GY + G ++TC G W +P C
Sbjct: 1703 DPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Score = 47.0 bits (110), Expect = 5e-05
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQCE 171
C PGE NG+ I +D S GS ++FSC E + L G+ + C+ + + WS P C+
Sbjct: 486 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544
Query: 172 IVKC 175
+ C
Sbjct: 545 VKTC 548
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/232 (20%), Positives = 94/232 (40%), Gaps = 35/232 (15%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQ--H 378
+ +G+ + + C GY+ + +EP ++C+KN W+ P C+ALC + + +G I +
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEP--LLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGY 1083
Query: 379 RKSRPAN-HCVYF----YGDEISFSCH-----ETSRFSAICQGDGTWSPRTPSCGDICNF 428
+ P + +C + +G + F+ H + + I + P G +
Sbjct: 1084 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGS--DL 1141
Query: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPE 488
PP I G Y F+ ++ + D G + ++S ++ + + +
Sbjct: 1142 PPTINAGLYGN------FRAQLRFISDFSISYEG---FNITFSEYNLEPCEDPGIPQYGS 1192
Query: 489 LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKC 538
+ + + +T C SGY + G I C G R W +P+C
Sbjct: 1193 RIGFNFGIG-------DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1237
Score = 43.1 bits (100), Expect = 7e-04
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P + NG+ G + ++ G +V +SCD + L G SI+C E W P C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 235 EKITC 239
+ TC
Sbjct: 544 KVKTC 548
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/333 (22%), Positives = 114/333 (34%), Gaps = 92/333 (27%)
Query: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC-DADSK--WNPSPPACE 295
CR P V +G G DT+VF+C G+ L+G I C +++ W PSPP C
Sbjct: 1528 CRDPGVPMNGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1585
Query: 296 PNSCINL---------PDIPHASWETYPRPTKEDV---------YVVGTV-LRYRCHPGY 336
NL P+ PH P P D YV+ + + P Y
Sbjct: 1586 APCGGNLTGSSGFILSPNFPH------PYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1639
Query: 337 K-------PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVY 389
P ++ P Q + PE ++ + T H R ++ V
Sbjct: 1640 DFLYIYDGPDSNSPLIGSFQDSK------------LPE-RIESSSNTMHLAFR-SDGSVS 1685
Query: 390 FYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHG-----HYKQSSSYS 444
+ G + + + SC D P I +G YK S+
Sbjct: 1686 YTGFHLEYK-----------------AKLRESCFD----PGNIMNGTRLGMDYKLGST-- 1722
Query: 445 FFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPAPQCKALCRKPELVNGRLSVDKD 499
+ Y CD GY+L G + L+C W+ P C A C +V
Sbjct: 1723 -----VTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS-RSTGSEGTVLSP 1776
Query: 500 QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
Y P+N ++ + Y + P+ G ++
Sbjct: 1777 NY--PKNYSVGHNCVYSIAVPKEFVVFGQFVFF 1807
Score = 42.0 bits (97), Expect = 0.002
Identities = 57/237 (24%), Positives = 77/237 (32%), Gaps = 64/237 (27%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG +G+ D S GS + FSC G+ L CE + WSHPLP C+
Sbjct: 1010 CLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1065
Query: 173 VKCKPPPDIRNGRHS----GEENFYAYGFSVTYSCD-----------PRFSLLGHASISC 217
+ C D+R + G FY + T++ D F L H
Sbjct: 1066 L-C--GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLL 1122
Query: 218 TVENETIG------VWRPSPPTCE------------------------KIT--------C 239
EN + PPT IT C
Sbjct: 1123 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1182
Query: 240 RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK--WNPSPPAC 294
P + GF + DT+ F C G+ L G+S I C + W+ P C
Sbjct: 1183 EDPGIPQYGSRIGFN--FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1237
Score = 40.4 bits (93), Expect = 0.005
Identities = 16/40 (40%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Query: 448 EEIIYECDKGYILVGQAKLSCSYS---HWSAPAPQCKALC 484
+ I +EC GY L+G + L+C + +W+ P P+C+ALC
Sbjct: 2244 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2283
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C+PPP + N E++ + G + Y C P F+L+G+A ++C + +PP C
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERL--QMDGAPPVC 2452
Query: 235 E 235
+
Sbjct: 2453 Q 2453
Score = 38.5 bits (88), Expect = 0.018
Identities = 62/263 (23%), Positives = 87/263 (33%), Gaps = 65/263 (24%)
Query: 254 GPIYNYKDTIVFKCQKGFVLRGSSVIHC--DADSKWNPSPPACEP---------NSCINL 302
G + TI F+C G+ L G+S + C WN P CE N I
Sbjct: 2237 GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYS 2296
Query: 303 PDIPHASWETYPR----------PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL 352
P P + YP P +Y+ TVL+ +P D T
Sbjct: 2297 PGYP----DEYPNFQDCFWLVRVPPGNGIYINFTVLQT------EPIYDFITV------- 2339
Query: 353 RWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE---TSRFSAIC 409
+ G P N+ +I Q A VY ++I H TS F +
Sbjct: 2340 ----WDG--------PDQNSPQIGQF-SGNTALESVYSTSNQILIKFHSDFTTSGFFVLS 2386
Query: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCS 469
+ R +C PP + + + I Y+C G+ LVG A L+C
Sbjct: 2387 YH--AYQLR------VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2438
Query: 470 YS---HWSAPAPQCKALCRKPEL 489
P C+ LC EL
Sbjct: 2439 LGERLQMDGAPPVCQVLCPANEL 2461
Score = 37.0 bits (84), Expect = 0.052
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172
C PG + G I + G + FSCS G+ L G++ C R V WS PLP+C +
Sbjct: 1182 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-V 1238
Query: 173 VKC 175
+C
Sbjct: 1239 AEC 1241
Score = 36.6 bits (83), Expect = 0.067
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Query: 235 EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
EK +C P + G G ++ +D + F+CQ GF L G I C +++W+ + P C
Sbjct: 660 EKESCGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717
Score = 36.6 bits (83), Expect = 0.067
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 104 YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLI-GSTTSRCEVQDRGVG 162
YNTF + C PG N + + GS I C EGF G+ T C + D V
Sbjct: 826 YNTFG-HNECPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVM 883
Query: 163 WSHPLPQC 170
WS +P+C
Sbjct: 884 WSGLIPKC 891
Score = 36.6 bits (83), Expect = 0.067
Identities = 65/309 (21%), Positives = 108/309 (34%), Gaps = 57/309 (18%)
Query: 233 TCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSP 291
T +C P + HG +G ++ T+ F C G+ L + C+ + W+
Sbjct: 1004 TVNTYSCLDPGIPVHGRR---YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL 1060
Query: 292 PACE---------PNSCINLPDIPHASWETYPRP---TKEDVYVVGTVLRYRCHPGYKPT 339
P C+ P+ I P P E YP T G +++ H +
Sbjct: 1061 PTCDALCGGDVRGPSGTILSPGYP----EFYPNSLNCTWTVDVTHGKGVQFNFHTFH--L 1114
Query: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRP--ANHCVYFYGDEIS 396
D ++ +N +T P P P +N G R ++ + + G I+
Sbjct: 1115 EDHHDYLLITENGSFTQPLARLTGSDLP-PTINAGLYGNFRAQLRFISDFSISYEGFNIT 1173
Query: 397 FSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDK 456
FS + C+ P P G F I + + + C
Sbjct: 1174 FSEYNLEP----CE-----DPGIPQYGSRIGFNFGIG--------------DTLTFSCSS 1210
Query: 457 GYILVGQAKLSC---SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPEN-----VT 508
GY L G +++ C WSAP P+C A C N + + + + EN +
Sbjct: 1211 GYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYS 1270
Query: 509 IQCDSGYGV 517
IQ +G G+
Sbjct: 1271 IQVQAGKGI 1279
Score = 36.2 bits (82), Expect = 0.088
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGN--RTWYPEVPKC 538
C +P+ + + + D+Y+ + V+ QCD GY + G ITC R W +P C
Sbjct: 2052 CPEPQTPSSGIKIG-DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Score = 35.8 bits (81), Expect = 0.11
Identities = 51/234 (21%), Positives = 84/234 (35%), Gaps = 33/234 (14%)
Query: 320 DVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQH 378
D Y+VG V+ ++C GY T + RW P C A C +G I
Sbjct: 2066 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILS- 2124
Query: 379 RKSRPANH-----CVYFYGDEISFSCH------ETSRFSAICQGDGTWSPRTPSCGDICN 427
P N+ C + I F H T + S + G +
Sbjct: 2125 -PGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSG 2183
Query: 428 FPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKP 487
P+I + + S + + +G+ +V QA Y S P P+
Sbjct: 2184 --PQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA-----YQLQSCPDPR-------- 2228
Query: 488 ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKCE 539
NG V + + + ++ +C GY ++G ++TC +R W +P+CE
Sbjct: 2229 PFRNG--FVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2280
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/239 (21%), Positives = 83/239 (34%), Gaps = 56/239 (23%)
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC----DADSKWNPSPPACEPN 297
PD E G ++ T+ F C + +VL+G+ I C + + W+ P C+
Sbjct: 487 PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 546
Query: 298 SCINLPDIPHASWETYPRPTKED-----VYVVGTV----------LRYRCHPGYKPTT-- 340
+C + P ++ + P + D V+V+ V + GY T
Sbjct: 547 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 606
Query: 341 -----DEPTTV-------------ICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSR 382
+P TV + + W Q E++ K+N EI +
Sbjct: 607 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGD 666
Query: 383 PANHCVYFYGDEISFSCHETSRF------------SAICQGDGTWSPRTPSCGDICNFP 429
P +Y + FS + RF S +CQ + WS P IC FP
Sbjct: 667 PGTP-LYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP----ICIFP 720
Score = 33.9 bits (76), Expect = 0.44
Identities = 51/230 (22%), Positives = 82/230 (35%), Gaps = 37/230 (16%)
Query: 314 PRPTKEDV-----YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPE 367
PRP + + VG + + C PGY + T + + W P CEALC
Sbjct: 2227 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2286
Query: 368 PKLNNGEITQHRKSRPANH-----CVYFY------GDEISFSCHETSR-FSAICQGDGTW 415
NG I + P + C + G I+F+ +T + I DG
Sbjct: 2287 ITAMNGTI--YSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGP- 2343
Query: 416 SPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSA 475
+P G G+ S YS +I+ + + G LS
Sbjct: 2344 DQNSPQIGQF--------SGNTALESVYS-TSNQILIKFHSDFTTSGFFVLSYH------ 2388
Query: 476 PAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC 525
A Q + P + N + + D++ + + QC G+ +VG +TC
Sbjct: 2389 -AYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTC 2437
Score = 32.7 bits (73), Expect = 0.97
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 13/93 (13%)
Query: 397 FSCHETSRFSAICQGDGTWSP--RTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454
FS TS F+ G + ++ SCG+ P + +G ++I Y C
Sbjct: 151 FSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVG------DKIRYSC 204
Query: 455 DKGYILVGQAKLSC-----SYSHWSAPAPQCKA 482
GYIL G +L+C + + W P P C+A
Sbjct: 205 VTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 32.3 bits (72), Expect = 1.3
Identities = 11/40 (27%), Positives = 20/40 (50%)
Query: 499 DQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
D + + + +C G+ ++G +SI C N W +P C
Sbjct: 678 DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717
Score = 30.8 bits (68), Expect = 3.7
Identities = 11/33 (33%), Positives = 17/33 (51%)
Query: 507 VTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
V+ CDSGY + + + C N W +P C+
Sbjct: 1032 VSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1064
Score = 30.4 bits (67), Expect = 4.8
Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 6/67 (8%)
Query: 450 IIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEP 504
++++C+ GYIL G + C S + W+ P C C L + ++ Y EP
Sbjct: 1900 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC-GGILTKRKGTILSPGYPEP 1958
Query: 505 ENVTIQC 511
+ + C
Sbjct: 1959 YDNNLNC 1965
Score = 30.4 bits (67), Expect = 4.8
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 3/36 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
C PPP + A +I + F+ G ++Y CLPG+
Sbjct: 2395 CQPPPPVPNA---EILTEDDEFEIGDIIRYQCLPGF 2427
Score = 30.0 bits (66), Expect = 6.3
Identities = 17/48 (35%), Positives = 23/48 (47%), Gaps = 6/48 (12%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTC 96
+CG P P L TRF G ++Y+C+ GY+ Q LTC
Sbjct: 177 SCGNP-----GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQ-LTC 218
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 174 bits (441), Expect = 2e-43
Identities = 111/318 (34%), Positives = 160/318 (50%), Gaps = 24/318 (7%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C S + P +S YP+
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPK 304
Query: 316 PTKE-----DVYVVGTVL 328
P + DV+V+ ++
Sbjct: 305 PEEGILDSLDVWVIAVIV 322
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 174 bits (441), Expect = 2e-43
Identities = 111/318 (34%), Positives = 160/318 (50%), Gaps = 24/318 (7%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C S + P +S YP+
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPK 304
Query: 316 PTKE-----DVYVVGTVL 328
P + DV+V+ ++
Sbjct: 305 PEEGILDSLDVWVIAVIV 322
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 169 bits (429), Expect = 5e-42
Identities = 110/302 (36%), Positives = 153/302 (50%), Gaps = 20/302 (6%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C S + P AS + PR
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP-ASSASGPR 303
Query: 316 PT 317
PT
Sbjct: 304 PT 305
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 62.4 bits (150), Expect = 1e-09
Identities = 56/202 (27%), Positives = 85/202 (42%), Gaps = 27/202 (13%)
Query: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE---WVYNT-FCIYKRCRHPGELRNG---- 122
++ G + + C GY + L C G W C C P +++NG
Sbjct: 117 YEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF 175
Query: 123 -QVEIKTDLSFGSQIEFSCS-----EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCK 176
+VE+ + + +SC + F LIG +T C D V WS P+C++VKC+
Sbjct: 176 SEVEV---FEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--DNSV-WSRAAPECKVVKCR 229
Query: 177 PPPDIRNGRH-SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
P + NG+ SG + Y +V + CD F L G +I C ++ W P P C
Sbjct: 230 FPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCL 284
Query: 236 KITCRKPDVSHGEMVSGFGPIY 257
K++ S SG P Y
Sbjct: 285 KVSTSSTTKSPASSASGPRPTY 306
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 169 bits (429), Expect = 5e-42
Identities = 110/302 (36%), Positives = 153/302 (50%), Gaps = 20/302 (6%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C S + P AS + PR
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP-ASSASGPR 303
Query: 316 PT 317
PT
Sbjct: 304 PT 305
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 62.4 bits (150), Expect = 1e-09
Identities = 56/202 (27%), Positives = 85/202 (42%), Gaps = 27/202 (13%)
Query: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE---WVYNT-FCIYKRCRHPGELRNG---- 122
++ G + + C GY + L C G W C C P +++NG
Sbjct: 117 YEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF 175
Query: 123 -QVEIKTDLSFGSQIEFSCS-----EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCK 176
+VE+ + + +SC + F LIG +T C D V WS P+C++VKC+
Sbjct: 176 SEVEV---FEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--DNSV-WSRAAPECKVVKCR 229
Query: 177 PPPDIRNGRH-SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
P + NG+ SG + Y +V + CD F L G +I C ++ W P P C
Sbjct: 230 FPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCL 284
Query: 236 KITCRKPDVSHGEMVSGFGPIY 257
K++ S SG P Y
Sbjct: 285 KVSTSSTTKSPASSASGPRPTY 306
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 169 bits (429), Expect = 5e-42
Identities = 110/302 (36%), Positives = 153/302 (50%), Gaps = 20/302 (6%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C S + P AS + PR
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP-ASSASGPR 303
Query: 316 PT 317
PT
Sbjct: 304 PT 305
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 62.4 bits (150), Expect = 1e-09
Identities = 56/202 (27%), Positives = 85/202 (42%), Gaps = 27/202 (13%)
Query: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE---WVYNT-FCIYKRCRHPGELRNG---- 122
++ G + + C GY + L C G W C C P +++NG
Sbjct: 117 YEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF 175
Query: 123 -QVEIKTDLSFGSQIEFSCS-----EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCK 176
+VE+ + + +SC + F LIG +T C D V WS P+C++VKC+
Sbjct: 176 SEVEV---FEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--DNSV-WSRAAPECKVVKCR 229
Query: 177 PPPDIRNGRH-SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235
P + NG+ SG + Y +V + CD F L G +I C ++ W P P C
Sbjct: 230 FPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCL 284
Query: 236 KITCRKPDVSHGEMVSGFGPIY 257
K++ S SG P Y
Sbjct: 285 KVSTSSTTKSPASSASGPRPTY 306
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 168 bits (425), Expect = 1e-41
Identities = 109/318 (34%), Positives = 159/318 (50%), Gaps = 25/318 (7%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C P +++ YP+
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKP-PVSNYPGYPK 303
Query: 316 PTKE-----DVYVVGTVL 328
P + DV+V+ ++
Sbjct: 304 PEEGILDSLDVWVIAVIV 321
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 168 bits (425), Expect = 1e-41
Identities = 109/318 (34%), Positives = 159/318 (50%), Gaps = 25/318 (7%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C P +++ YP+
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKP-PVSNYPGYPK 303
Query: 316 PTKE-----DVYVVGTVL 328
P + DV+V+ ++
Sbjct: 304 PEEGILDSLDVWVIAVIV 321
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 168 bits (425), Expect = 1e-41
Identities = 109/318 (34%), Positives = 159/318 (50%), Gaps = 25/318 (7%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+ YK T++F+C KGF L GS I CD++S W+P P C P +++ YP+
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKP-PVSNYPGYPK 303
Query: 316 PTKE-----DVYVVGTVL 328
P + DV+V+ ++
Sbjct: 304 PEEGILDSLDVWVIAVIV 321
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 167 bits (424), Expect = 2e-41
Identities = 113/333 (33%), Positives = 162/333 (48%), Gaps = 39/333 (11%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---EPNSCINLPDIPH----- 307
+ YK T++F+C KGF L GS I CD++S W+P P C P S P + H
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTS 304
Query: 308 -------ASWETYPRPTKE-----DVYVVGTVL 328
+S YP+P + DV+V+ ++
Sbjct: 305 STTKSPASSASGYPKPEEGILDSLDVWVIAVIV 337
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 167 bits (424), Expect = 2e-41
Identities = 113/333 (33%), Positives = 162/333 (48%), Gaps = 39/333 (11%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---EPNSCINLPDIPH----- 307
+ YK T++F+C KGF L GS I CD++S W+P P C P S P + H
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTS 304
Query: 308 -------ASWETYPRPTKE-----DVYVVGTVL 328
+S YP+P + DV+V+ ++
Sbjct: 305 STTKSPASSASGYPKPEEGILDSLDVWVIAVIV 337
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 167 bits (423), Expect = 3e-41
Identities = 112/316 (35%), Positives = 155/316 (49%), Gaps = 33/316 (10%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---EPNSCINLPDIPH----- 307
+ YK T++F+C KGF L GS I CD++S W+P P C P S P + H
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTS 304
Query: 308 ------ASWETYPRPT 317
AS + PRPT
Sbjct: 305 STTKSPASSASGPRPT 320
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 167 bits (423), Expect = 3e-41
Identities = 112/316 (35%), Positives = 155/316 (49%), Gaps = 33/316 (10%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---EPNSCINLPDIPH----- 307
+ YK T++F+C KGF L GS I CD++S W+P P C P S P + H
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTS 304
Query: 308 ------ASWETYPRPT 317
AS + PRPT
Sbjct: 305 STTKSPASSASGPRPT 320
Score = 99.8 bits (247), Expect = 6e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
Query: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 165 bits (418), Expect = 1e-40
Identities = 102/279 (36%), Positives = 143/279 (51%), Gaps = 19/279 (6%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
+ YK T++F+C KGF L GS I CD++S W+P P C
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 100 bits (249), Expect = 4e-21
Identities = 76/250 (30%), Positives = 112/250 (44%), Gaps = 29/250 (11%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW 540
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 541 ETPEGCEQVL 550
P+ E +L
Sbjct: 286 GYPKPEEGIL 295
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/234 (23%), Positives = 100/234 (42%), Gaps = 22/234 (9%)
Query: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP----QCEIVKCKPPPDIRNGRHSG 188
G ++++ C +G+F I + + DR W LP C C D NG+
Sbjct: 57 GERVDYKCKKGYFYIPPLATHT-ICDRNHTW---LPVSDDACYRETCPYIRDPLNGQAVP 112
Query: 189 EENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPD-VSHG 247
Y +G+ + + C+ + L+G + C ++ ++ +W PP CEK+ C P + +G
Sbjct: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPICEKVLCTPPPKIKNG 171
Query: 248 EMVSGFGPIYNYKDTIVFKCQKG-----FVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302
+ ++ Y D + + C F L G S I+C +S W+ + P C+ C
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC-RF 230
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
P + + + + Y TV+ + C G+ D T++C N W P
Sbjct: 231 PVVENGKQIS---GFGKKFYYKATVM-FECDKGF--YLDGSDTIVCDSNSTWDP 278
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 165 bits (418), Expect = 1e-40
Identities = 102/279 (36%), Positives = 143/279 (51%), Gaps = 19/279 (6%)
Query: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
Query: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
Query: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
Query: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
+ YK T++F+C KGF L GS I CD++S W+P P C
Sbjct: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 100 bits (249), Expect = 4e-21
Identities = 76/250 (30%), Positives = 112/250 (44%), Gaps = 29/250 (11%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Query: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEW 540
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 541 ETPEGCEQVL 550
P+ E +L
Sbjct: 286 GYPKPEEGIL 295
Score = 84.3 bits (207), Expect = 3e-16
Identities = 56/234 (23%), Positives = 100/234 (42%), Gaps = 22/234 (9%)
Query: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP----QCEIVKCKPPPDIRNGRHSG 188
G ++++ C +G+F I + + DR W LP C C D NG+
Sbjct: 57 GERVDYKCKKGYFYIPPLATHT-ICDRNHTW---LPVSDDACYRETCPYIRDPLNGQAVP 112
Query: 189 EENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPD-VSHG 247
Y +G+ + + C+ + L+G + C ++ ++ +W PP CEK+ C P + +G
Sbjct: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPICEKVLCTPPPKIKNG 171
Query: 248 EMVSGFGPIYNYKDTIVFKCQKG-----FVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302
+ ++ Y D + + C F L G S I+C +S W+ + P C+ C
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC-RF 230
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
P + + + + Y TV+ + C G+ D T++C N W P
Sbjct: 231 PVVENGKQIS---GFGKKFYYKATVM-FECDKGF--YLDGSDTIVCDSNSTWDP 278
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 161 bits (407), Expect = 2e-39
Identities = 143/554 (25%), Positives = 212/554 (38%), Gaps = 102/554 (18%)
Query: 69 TRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPG----ELRNGQ 123
+ F + +TC GY+ ++ C S+G+W C C PG +R+GQ
Sbjct: 2753 SEFNLNDVVNFTCNTGYLLQGVSRA-QCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQ 2811
Query: 124 VEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRN 183
+G I + C +GF+L+GS+ C W LP+C + C P N
Sbjct: 2812 QNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGL---WDRSLPKCLAISCGHPGVPAN 2868
Query: 184 GRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT---CR 240
+GE + YG V YSC SL+G+ + C ++ W + P C C
Sbjct: 2869 AVLTGE--LFTYGAVVHYSCRGSESLIGNDTRVCQEDSH----WSGALPHCTGNNPGFCG 2922
Query: 241 KPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSC 299
P +HG S G + K + F C+ G LRGS C + W+ P CE SC
Sbjct: 2923 DPGTPAHG---SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSC 2979
Query: 300 INLPDIP------------------HASWETYPRP---------------TKEDVYVV-- 324
N P P +A WE Y T D ++
Sbjct: 2980 GN-PGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISC 3038
Query: 325 ---GTV---------------LRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCC 365
GT+ + Y+C+PGY T+ C K+ RW P + C+A+ C
Sbjct: 3039 GDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLC 3098
Query: 366 PE-PKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFS----AICQGDGTWSPRTP 420
P+ P + NG + + +G IS+SC + + S C+G G W P
Sbjct: 3099 PQPPPVQNGTV---------EGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIP 3149
Query: 421 SCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAP 478
C + C P A G + S +K E+ ++C +ILVG ++ C + WS P
Sbjct: 3150 QCLPVFCGDPGIPAEG--RLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQP 3207
Query: 479 QC----KALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPE 534
C C P + + Y V +C GY + G + TC N TW
Sbjct: 3208 TCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGI 3267
Query: 535 VPKCEWETPEGCEQ 548
+C P C Q
Sbjct: 3268 QTEC---IPHACRQ 3278
Score = 148 bits (373), Expect = 2e-35
Identities = 118/453 (26%), Positives = 187/453 (41%), Gaps = 53/453 (11%)
Query: 110 YKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV-GWSHPLP 168
Y HP L+NG + +T + GS++ + C G+ ++G + + C G+ W P
Sbjct: 2432 YCSLTHP--LKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTP 2489
Query: 169 QCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW- 227
C+ V C P NG +G E + V Y C F L +S T + G+W
Sbjct: 2490 LCQAVSCGIPESPGNGSFTGNE--FTLDSKVVYECHEGFKL--ESSQQATAVCQEDGLWS 2545
Query: 228 -RPSPPTCEKITCRKPDVSHGEMVSG---FGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
+ PPTC+ + C + E V G + Y ++ C G+ L G ++ C A
Sbjct: 2546 NKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQA 2605
Query: 284 DSKWN--PSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTD 341
+ WN P+C SC +L P+ + + V G + C+ GY T
Sbjct: 2606 NGTWNIGDERPSCRVISCGSLSFPPNGN-------KIGTLTVYGATAIFTCNTGY--TLV 2656
Query: 342 EPTTVICQKNLRWTPYQGCEALC----CPEP-KLNNGEITQHRKSRPANHCVYFYGDEIS 396
C N W+ G E C C P + NG I+ + Y D +
Sbjct: 2657 GSHVRECLANGLWS---GSETRCLAGHCGSPDPIVNGHISGDG---------FSYRDTVV 2704
Query: 397 FSCHETSRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEII 451
+ C+ R IC D WS +TP C I C P AHG + S ++ + +
Sbjct: 2705 YQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHG-FTNGSEFN-LNDVVN 2762
Query: 452 YECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEP----E 505
+ C+ GY+L G ++ C S WS+P P C+ + C P V + + + E
Sbjct: 2763 FTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGM 2822
Query: 506 NVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
++ C G+ ++G ++TC N W +PKC
Sbjct: 2823 SILYHCKKGFYLLGSSALTCMANGLWDRSLPKC 2855
Score = 144 bits (362), Expect = 3e-34
Identities = 104/356 (29%), Positives = 158/356 (44%), Gaps = 40/356 (11%)
Query: 79 YTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTDLSFGSQIE 137
Y C GY ++ T C ++G W C C PG L NG ++ TD +F +
Sbjct: 3004 YACWEGY-KTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANG-IQFGTDFTFNKTVS 3061
Query: 138 FSCSEGFFL--IGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAY 195
+ C+ G+ + + S T RC R W+ P C+ V C PP ++NG G + + +
Sbjct: 3062 YQCNPGYVMEAVTSATIRCTKDGR---WNPSKPVCKAVLCPQPPPVQNGTVEGSD--FRW 3116
Query: 196 GFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
G S++YSC + L A +SC E GVW+ P C + C P + +SG
Sbjct: 3117 GSSISYSCMDGYQLSHSAILSC----EGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKS- 3171
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC-EP--NSCINLPDIPHASWET 312
+ YK + F+C+ F+L GSS C AD W+ P C +P N+C + P PH +
Sbjct: 3172 -FTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD-PGTPHFGIQN 3229
Query: 313 YPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ-GCEALCCPEPKLN 371
R Y VG+ + +RC GY TT C NL W+ Q C C +P
Sbjct: 3230 SSRG-----YEVGSTVFFRCRKGYH--IQGSTTRTCLANLTWSGIQTECIPHACRQP--- 3279
Query: 372 NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA-----ICQGDGTWSPRTPSC 422
E H R + + +G + ++CH + C+ D W+ ++P C
Sbjct: 3280 --ETPAHADVRAID--LPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331
Score = 136 bits (343), Expect = 5e-32
Identities = 135/589 (22%), Positives = 214/589 (36%), Gaps = 119/589 (20%)
Query: 33 LFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQ 92
++Q + L AV +CG P + P + + T F + + Y C G+ S Q
Sbjct: 2481 MYQWDSLTPLCQAV--SCGIPES-----PGNGSFTGNEFTLDSKVVYECHEGFKLESSQQ 2533
Query: 93 -TLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLS--------------FGSQIE 137
T C DG W + + P I+ LS +G+Q+
Sbjct: 2534 ATAVCQEDGLWS-------NKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVL 2586
Query: 138 FSCSEGFFLIGSTTSRCEVQDRGVGWS--HPLPQCEIVKCKPPPDIRNGRHSGEENFYAY 195
SCS G++L G RC+ W+ P C ++ C NG G Y
Sbjct: 2587 LSCSPGYYLEGWRLLRCQANGT---WNIGDERPSCRVISCGSLSFPPNGNKIG--TLTVY 2641
Query: 196 GFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
G + ++C+ ++L+G C G+W S C C PD +SG G
Sbjct: 2642 GATAIFTCNTGYTLVGSHVRECLAN----GLWSGSETRCLAGHCGSPDPIVNGHISGDG- 2696
Query: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
++Y+DT+V++C GF L G+SV C D KW+ P C P +C + + H
Sbjct: 2697 -FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGF------ 2749
Query: 316 PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCPEPKLNNGE 374
T + + V+ + C+ GY + C+ N +W +P C + C +P
Sbjct: 2750 -TNGSEFNLNDVVNFTCNTGY--LLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENA 2806
Query: 375 ITQHRKSRPAN---------HC-------------------------------------- 387
I +++ P + HC
Sbjct: 2807 IRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVP 2866
Query: 388 --------VYFYGDEISFSCHETSRF----SAICQGDGTWSPRTPSC----GDICNFPPK 431
++ YG + +SC + + +CQ D WS P C C P
Sbjct: 2867 ANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGT 2926
Query: 432 IAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPEL 489
AHG + K + + C+ G+ L G + +C + WS P C+A+ C P
Sbjct: 2927 PAHGSRLGDDFKT--KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGT 2984
Query: 490 VNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ V D + +V C GY G + C+ N TW P C
Sbjct: 2985 PTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC 3033
Score = 134 bits (337), Expect = 2e-31
Identities = 138/552 (25%), Positives = 201/552 (36%), Gaps = 64/552 (11%)
Query: 43 LPAVLG-NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGE 101
LP L +CG P P + LT F G + Y+C G T C D
Sbjct: 2852 LPKCLAISCGHP-----GVPANAVLTGELFTYGAVVHYSCR-GSESLIGNDTRVCQEDSH 2905
Query: 102 WVYNT-FCIYKR---CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQ 157
W C C PG +G + D S + FSC G L GS C +
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHGS-RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLN 2964
Query: 158 DRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217
WS P CE V C P NG + + SV Y+C + G + C
Sbjct: 2965 G---SWSGLQPVCEAVSCGNPGTPTNGMIVSSDGIL-FSSSVIYACWEGYKTSGLMTRHC 3020
Query: 218 TVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSG--FGPIYNYKDTIVFKCQKGFVLRG 275
T G W + P C I+C P G + +G FG + + T+ ++C G+V+
Sbjct: 3021 TAN----GTWTGTAPDCTIISCGDP----GTLANGIQFGTDFTFNKTVSYQCNPGYVMEA 3072
Query: 276 --SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCH 333
S+ I C D +WNPS P C+ C P + + + E + G+ + Y C
Sbjct: 3073 VTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSD-------FRWGSSISYSCM 3125
Query: 334 PGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYG 392
GY+ + C+ W C + C +P G + R S + + Y
Sbjct: 3126 DGYQ--LSHSAILSCEGRGVWKGEIPQCLPVFCGDP----GIPAEGRLSGKS----FTYK 3175
Query: 393 DEISFSCHE----TSRFSAICQGDGTWSPRTPSCGD----ICNFPPKIAHGHYKQSSSYS 444
E+ F C +CQ DGTWS P+C D C P G S Y
Sbjct: 3176 SEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYE 3235
Query: 445 FFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQC-KALCRKPELVNGRLSVDKDQYV 502
+ + C KGY + G +C + WS +C CR+PE D
Sbjct: 3236 -VGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPT 3294
Query: 503 EPENVTIQCDSGYGVV-GPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPN 561
+ C G+ + G + TC + W + P C+ + + +T P
Sbjct: 3295 FGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTK------TPV 3348
Query: 562 PEDVKMALEVYK 573
P DV ++K
Sbjct: 3349 PSDVFFVNSLWK 3360
Score = 126 bits (317), Expect = 5e-29
Identities = 125/508 (24%), Positives = 202/508 (39%), Gaps = 58/508 (11%)
Query: 66 LTETRFKTGTTLKYTCLPGY-VRSHSTQTLTCNSDGEWVYNT---FCIYKRCRHPGELRN 121
L T G+ + Y C PGY + HS T N G + +++ C C P N
Sbjct: 2445 LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGN 2504
Query: 122 GQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH--PLPQCEIVKCKPPP 179
G + + S++ + C EGF L S + Q+ G+ WS+ P C+ V C P
Sbjct: 2505 GSF-TGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGL-WSNKGKPPTCKPVAC-PSI 2561
Query: 180 DIRNGRH------SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWR--PSP 231
+ + H SG N YG V SC P + L G + C + G W
Sbjct: 2562 EAQLSEHVIWRLVSGSLN--EYGAQVLLSCSPGYYLEGWRLLRC----QANGTWNIGDER 2615
Query: 232 PTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSP 291
P+C I+C +S + G + Y T +F C G+ L GS V C A+ W+ S
Sbjct: 2616 PSCRVISC--GSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSE 2673
Query: 292 PACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKN 351
C C + I + D + + Y+C+PG++ + IC ++
Sbjct: 2674 TRCLAGHCGSPDPIVNGH-------ISGDGFSYRDTVVYQCNPGFRLV--GTSVRICLQD 2724
Query: 352 LRWTPYQGCEALCCPEPKLNNGEITQHRKSRPA----NHCVYFYGDEISFSCHETSRFSA 407
+W+ G +C P IT PA N + D ++F+C+
Sbjct: 2725 HKWS---GQTPVCVP--------ITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 2773
Query: 408 I----CQGDGTWSPRTPSCGDI-CNFPPKIAHG--HYKQSSSYSF-FKEEIIYECDKGYI 459
+ C+ +G WS P+C + C+ P + + H +Q+ SF + I+Y C KG+
Sbjct: 2774 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFY 2833
Query: 460 LVGQAKLSC-SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVV 518
L+G + L+C + W P+C A+ V + + + V C ++
Sbjct: 2834 LLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLI 2893
Query: 519 GPQSITCSGNRTWYPEVPKCEWETPEGC 546
G + C + W +P C P C
Sbjct: 2894 GNDTRVCQEDSHWSGALPHCTGNNPGFC 2921
Score = 54.3 bits (129), Expect = 3e-07
Identities = 59/268 (22%), Positives = 98/268 (36%), Gaps = 47/268 (17%)
Query: 111 KRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV--GWSHPLP 168
+ C P +NG + I +D S G + F C G+ LIG C+ G+ W++P P
Sbjct: 2086 QNCPDPPPFQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTCQ---HGINRNWNYPFP 2141
Query: 169 QCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTY----------SCDPRFSL-LGHASISC 217
+C+ C +NG Y+ GF Y + P + + +
Sbjct: 2142 RCD-APCGYNVTSQNG------TIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQT 2194
Query: 218 TVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSS 277
N+ I VW + P + + Y+ + ++ K F G
Sbjct: 2195 EAVNDYIAVW-------DGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFF 2247
Query: 278 VIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYK 337
V++ A PP P +P A T++D + +G ++Y+CHPGY
Sbjct: 2248 VLNFHAFQLKKCQPP----------PAVPQAE-----MLTEDDDFEIGDFVKYQCHPGYT 2292
Query: 338 PTTDEPTTVICQKNLRWT-PYQGCEALC 364
+ T L++ CEA C
Sbjct: 2293 LVGTDILTCKLSSQLQFEGSLPTCEAQC 2320
Score = 50.8 bits (120), Expect = 3e-06
Identities = 61/285 (21%), Positives = 83/285 (29%), Gaps = 77/285 (27%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P NGR +G + F G +V +SC+ + L G SI+C ET+ W P C
Sbjct: 349 CPDPGIPENGRRAGSD-FSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPIC 407
Query: 235 EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
TC G LRG PS
Sbjct: 408 RARTC------------------------------GSNLRG-------------PSGVIT 424
Query: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTT-------------- 340
PN + D H W T D + + GY T
Sbjct: 425 SPNYPVQYEDNAHCVWVI--TTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVL 482
Query: 341 ------DEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPA-------NHC 387
P ++ N W Q +++ P K EI + P
Sbjct: 483 YVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGS 542
Query: 388 VYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTPSCGDICNF 428
+ +GD ++F C CQ + WS PSC C F
Sbjct: 543 SFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFF 587
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/262 (22%), Positives = 101/262 (38%), Gaps = 46/262 (17%)
Query: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADS--KWNPSPPAC-- 294
C++P + + G Y D + F+C+ G+ L+G S I C + +WN P C
Sbjct: 1916 CQEPALPSNSIK--IGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIA 1973
Query: 295 -------EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVI 347
I P P +YP + + + + Y H + + E
Sbjct: 1974 TCGGTLSTLGGVILSPGFP----GSYPN-NLDCTWRISLPIGYGAHIQFLNFSTEANHDF 2028
Query: 348 CQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSR--F 405
+ ++ PY + + + ++ S ++FY D H +R F
Sbjct: 2029 LE--IQNGPYHTSPMI----GQFSGTDLPAALLSTTHETLIHFYSD------HSQNRQGF 2076
Query: 406 SAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAK 465
Q + +C D PP +G Y +S YS + + +EC GYIL+G
Sbjct: 2077 KLAYQ-----AYELQNCPD----PPPFQNG-YMINSDYS-VGQSVSFECYPGYILIGHPV 2125
Query: 466 LSCSYS---HWSAPAPQCKALC 484
L+C + +W+ P P+C A C
Sbjct: 2126 LTCQHGINRNWNYPFPRCDAPC 2147
Score = 46.2 bits (108), Expect = 9e-05
Identities = 23/60 (38%), Positives = 30/60 (50%), Gaps = 3/60 (5%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P +NG G+ G +VT+ CDP + L G A I+C N W+P PPTC
Sbjct: 1392 CNDPGMPQNGTRYGDSR--EAGDTVTFQCDPGYQLQGQAKITCVQLNNRF-FWQPDPPTC 1448
Score = 46.2 bits (108), Expect = 9e-05
Identities = 48/247 (19%), Positives = 89/247 (36%), Gaps = 77/247 (31%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEV-QDRGVGWSHPLPQCE 171
C PG + NG + TD GS I + C G+ ++ ++ C + D W LP C
Sbjct: 1565 CFDPGNIMNG-TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN 1623
Query: 172 IVKCKPPPDIRNGRHSGEENF-----YAYGFSVTYSC------DPRFSLLGH-------- 212
C G+++G E Y + ++ C F + G
Sbjct: 1624 -APC-------GGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTAL 1675
Query: 213 -----------------ASISCTVENETIGV------------------------WRPSP 231
+S+S + ET+ + ++ P
Sbjct: 1676 NDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVP 1735
Query: 232 PTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC----DADSKW 287
T + P+ +G + G ++ + F+C G++L+GS+ +HC +A ++W
Sbjct: 1736 RTSDTQCSSVPEPRYGRRI---GSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQW 1792
Query: 288 NPSPPAC 294
N + P+C
Sbjct: 1793 NDTIPSC 1799
Score = 40.4 bits (93), Expect = 0.005
Identities = 25/69 (36%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 104 YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLI-GSTTSRCEVQDRGVG 162
Y TF C PG NG+ GS + F C +GF GS + C +QD V
Sbjct: 690 YTTFG-QNECHDPGIPINGR-RFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVV 747
Query: 163 WSHPLPQCE 171
WS +P+CE
Sbjct: 748 WSSTVPRCE 756
Score = 38.9 bits (89), Expect = 0.014
Identities = 56/253 (22%), Positives = 91/253 (35%), Gaps = 28/253 (11%)
Query: 324 VGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSR 382
VG L + C GY+ T + W+ P C A C K N G + +
Sbjct: 1064 VGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLS--PNF 1121
Query: 383 PANH-----CVYFYGDEISFSCHETSRFSAICQGDG--TWSPRTPSCGDICNFPPKIAHG 435
P+N+ C+Y E H +R + +GD + + S + F G
Sbjct: 1122 PSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLG 1181
Query: 436 HYKQSSSYSFFKEEIIY--ECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGR 493
S+S + E + D+G+ L +Y+ + C P + N
Sbjct: 1182 LILNSTSNHLWLEFNTNGSDTDQGFQL--------TYTSFDL------VKCEDPGIPNYG 1227
Query: 494 LSVDKDQYVEPENVTIQCDSGYGVVGPQSITC-SGN-RTWYPEVPKCEWETPEGCEQVLT 551
+ + + V C+ GY + G ++TC SG+ R W +P C E +
Sbjct: 1228 YRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATS 1287
Query: 552 GKRLMQCLPNPED 564
G+ L P P D
Sbjct: 1288 GRILSPGYPAPYD 1300
Score = 37.7 bits (86), Expect = 0.030
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 4/36 (11%)
Query: 507 VTIQCDSGYGVVGPQSITC----SGNRTWYPEVPKC 538
+T QCDSGY ++ P SITC G +W +P C
Sbjct: 1587 ITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 37.7 bits (86), Expect = 0.030
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 112 RCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQC 170
+C E R G+ I ++ S GS + F C+ G+ L GST C+ V + W+ +P C
Sbjct: 1741 QCSSVPEPRYGR-RIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Query: 171 EIVKC 175
+V C
Sbjct: 1800 -VVPC 1803
Score = 37.4 bits (85), Expect = 0.040
Identities = 57/279 (20%), Positives = 89/279 (31%), Gaps = 62/279 (22%)
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD--ADSKWNPSPPACEP--- 296
P +G M++ Y+ ++ F+C G++L G V+ C + WN P C+
Sbjct: 2092 PPFQNGYMINSD---YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCG 2148
Query: 297 ------NSCINLPDIPHASWETYPR----------PTKEDVYVVGTVLRYRCHPGYKPTT 340
N I P P + YP P VY+ T+L+ Y
Sbjct: 2149 YNVTSQNGTIYSPGFP----DEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVW 2204
Query: 341 DEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
D P Q + + + G AL N + H V ++F
Sbjct: 2205 DGPD----QNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFV------LNFHAF 2254
Query: 401 ETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYIL 460
+ + C PP + + + Y+C GY L
Sbjct: 2255 QLKK---------------------CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTL 2293
Query: 461 VGQAKLSCSYS---HWSAPAPQCKALCRKPELVNGRLSV 496
VG L+C S + P C+A C E+ G V
Sbjct: 2294 VGTDILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGV 2332
Score = 37.0 bits (84), Expect = 0.052
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 171 EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217
E+ C PP +NG + Y+ G SV++ C P + L+GH ++C
Sbjct: 2084 ELQNCPDPPPFQNGYMINSD--YSVGQSVSFECYPGYILIGHPVLTC 2128
Score = 36.6 bits (83), Expect = 0.067
Identities = 47/219 (21%), Positives = 75/219 (34%), Gaps = 63/219 (28%)
Query: 324 VGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNG--------- 373
+ + + + C PGY + DEP ++C++N +W C+ALC + +G
Sbjct: 892 IRSTVTFSCDPGYTLSDDEP--LVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPD 949
Query: 374 ------------EITQHRKSRPANHCVYFYGDEISFSCHETSRFS-AICQGDGTWSPRTP 420
E++ + + H + E FS + + G+ P T
Sbjct: 950 FYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTI 1009
Query: 421 SCGDICNFPPKIAHGHYKQSSSYSF------FKEEIIYECDK------------------ 456
G NF ++ + S S+ F E + CD
Sbjct: 1010 KAGLFGNFTAQL---RFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGD 1066
Query: 457 --------GYILVGQAKLSC---SYSHWSAPAPQCKALC 484
GY L G KL+C WSAP P+C A C
Sbjct: 1067 SLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAEC 1105
Score = 36.2 bits (82), Expect = 0.088
Identities = 22/61 (36%), Positives = 32/61 (52%), Gaps = 7/61 (11%)
Query: 484 CRKPEL-VNGRLSVDKDQYVEPENVTIQCDSGY-GVVGPQSITC---SGNRTWYPEVPKC 538
C P + +NGR D+ ++ +V+ CD G+ G +SITC GN W VP+C
Sbjct: 698 CHDPGIPINGRRFGDR--FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRC 755
Query: 539 E 539
E
Sbjct: 756 E 756
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 6/65 (9%)
Query: 233 TCEKITCRKPDVSHGEMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPS 290
T E +C P + V+G G + + T+ F C G+ L + C+ + +WN +
Sbjct: 868 TLESDSCLDPGIP----VNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHA 923
Query: 291 PPACE 295
P+C+
Sbjct: 924 LPSCD 928
Score = 35.8 bits (81), Expect = 0.11
Identities = 29/113 (25%), Positives = 44/113 (38%), Gaps = 22/113 (19%)
Query: 424 DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKA 482
D C P +GH + + + + + CD GY L L C +H W+ P C A
Sbjct: 872 DSCLDPGIPVNGH-RHGGDFGI-RSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA 929
Query: 483 LCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEV 535
LC Y++ ++ T+ G+ P S+ C TW EV
Sbjct: 930 LC--------------GGYIQGKSGTV-LSPGFPDFYPNSLNC----TWTIEV 963
Score = 35.4 bits (80), Expect = 0.15
Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 5/60 (8%)
Query: 238 TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK---WNPSPPAC 294
TC P + + +G DT+ F+C G+ L+G + I C + W P PP C
Sbjct: 1391 TCNDPGMPQNG--TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Score = 35.0 bits (79), Expect = 0.20
Identities = 19/64 (29%), Positives = 28/64 (43%), Gaps = 1/64 (1%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQCE 171
C PG NG+ G+ ++FSC + + L GS + C+ V + WS P C
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Query: 172 IVKC 175
C
Sbjct: 409 ARTC 412
Score = 35.0 bits (79), Expect = 0.20
Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 4/41 (9%)
Query: 448 EEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQCKALC 484
+ + ++CD GY L GQAK++C + W P C A C
Sbjct: 1412 DTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAAC 1452
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 5/40 (12%)
Query: 448 EEIIYECDKGYILVGQAKLSCSYS-----HWSAPAPQCKA 482
++I Y C GYIL G A L+C S W PAP C+A
Sbjct: 165 DKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRA 204
Score = 34.7 bits (78), Expect = 0.26
Identities = 55/251 (21%), Positives = 91/251 (36%), Gaps = 46/251 (18%)
Query: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRK 380
Y VG + + C+PGY T N W P+ C+A C NG I +
Sbjct: 2104 YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTI--YSP 2161
Query: 381 SRPANH-----CVYF------YGDEISFSCHETSRFSA-ICQGDGTWSPRTPSCGDICNF 428
P + C++ +G I+F+ +T + I DG +P G
Sbjct: 2162 GFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDGP-DQNSPQLG----- 2215
Query: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHW-----SAPAPQCKAL 483
+ G+ ++YS + ++ K +S+ + A Q K
Sbjct: 2216 ---VFSGNTALETAYSSTNQVLL-------------KFHSDFSNGGFFVLNFHAFQLKKC 2259
Query: 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKCEWE 541
P + + + D + + V QC GY +VG +TC S + +P CE +
Sbjct: 2260 QPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQ 2319
Query: 542 TPEGCEQVLTG 552
P +V TG
Sbjct: 2320 CP--ANEVRTG 2328
Score = 34.3 bits (77), Expect = 0.33
Identities = 58/287 (20%), Positives = 104/287 (36%), Gaps = 63/287 (21%)
Query: 238 TCRKPDVSHGEMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVIHCDAD----SKWNPSP 291
TC P GE++ G G +N D I + C G++L G +++ C + W+
Sbjct: 144 TCGNP----GEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPA 199
Query: 292 PACE-----------PNSCINLPDIP-------HASWETYPRPTKEDVYVVGTVLRYRCH 333
P C +S I+ P P +W P + + +V T ++
Sbjct: 200 PFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEP-GDTIALVFT--DFQLE 256
Query: 334 PGYK----PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVY 389
GY T+ P+ + NL P P +++ + + +NH
Sbjct: 257 EGYDFLEISGTEAPSIWLTGMNL-------------PSPVISSKNWLRLHFTSDSNHRRK 303
Query: 390 FYGD--EISFSCHETSR-FSAICQGDGTWSPRTPSCG------DICNFPPKIAHGHYKQS 440
+ ++ + SR + DG+ S G D+C P I +
Sbjct: 304 GFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCP-DPGIPENGRRAG 362
Query: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC-----SYSHWSAPAPQCKA 482
S +S + + C+ Y+L G ++C + + WS P C+A
Sbjct: 363 SDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRA 409
Score = 34.3 bits (77), Expect = 0.33
Identities = 34/109 (31%), Positives = 46/109 (42%), Gaps = 10/109 (9%)
Query: 73 TGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCI------YKRCRHPGELRNGQVEI 126
TG+ L +T G + + Q L SD Y F I + C PG + I
Sbjct: 1001 TGSVLPHTIKAGLFGNFTAQ-LRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSR-RI 1058
Query: 127 KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKC 175
G + FSC G+ L G+T C R V WS PLP+C + +C
Sbjct: 1059 GFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRV-WSAPLPRC-VAEC 1105
Score = 33.9 bits (76), Expect = 0.44
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 505 ENVTIQCDSGYGVVGPQSITC---SGNRTWYPEVPKC 538
+ VT QCD GY + G ITC + W P+ P C
Sbjct: 1412 DTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Score = 33.5 bits (75), Expect = 0.57
Identities = 60/237 (25%), Positives = 85/237 (35%), Gaps = 39/237 (16%)
Query: 320 DVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL--RWT-PYQGCEALCCPEPKLNNGEIT 376
D Y+V VL ++C PGY T + + C RW P C A C G I
Sbjct: 1930 DRYMVNDVLSFQCEPGY--TLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLSTLGGVIL 1987
Query: 377 Q--HRKSRPAN-HCVYF------YGDEI---SFSCHETSRFSAICQGDGTWSPRTPSCGD 424
S P N C + YG I +FS F I G SP
Sbjct: 1988 SPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSG 2047
Query: 425 ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALC 484
++ H YS + +G+ L QA Y + P P
Sbjct: 2048 TDLPAALLSTTHETLIHFYSDHSQN-----RQGFKLAYQA-----YELQNCPDP------ 2091
Query: 485 RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSG--NRTWYPEVPKCE 539
P NG + ++ D Y ++V+ +C GY ++G +TC NR W P+C+
Sbjct: 2092 --PPFQNGYM-INSD-YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144
Score = 33.1 bits (74), Expect = 0.75
Identities = 48/240 (20%), Positives = 87/240 (36%), Gaps = 44/240 (18%)
Query: 263 IVFKCQKGFVLRGSSVIHCDADSK----WNPSPPACEPNSCINLPDIPHA--SWETYPRP 316
+ F C+ +VL+GS I C ++ W+ P C +C + P + YP
Sbjct: 372 VQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQ 431
Query: 317 TKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPK------- 369
+++ + V + TT +P VI + +G + L +
Sbjct: 432 YEDNAHCVWVI-----------TTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRS 480
Query: 370 ----LNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDI 425
L + S ++ D+ S + + I +G CGD
Sbjct: 481 VLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG---------GCGD- 530
Query: 426 CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKALC 484
P A+G K++ S + + +EC + LVG+ ++C ++ WS P C C
Sbjct: 531 ---PGIPAYG--KRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSC 585
Score = 32.7 bits (73), Expect = 0.97
Identities = 11/38 (28%), Positives = 20/38 (52%)
Query: 501 YVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
++ + +T +C + + +VG + ITC N W P C
Sbjct: 544 FLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 4/59 (6%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCE 171
C PG NG D S + FSC G+ L CE R W+H LP C+
Sbjct: 874 CLDPGIPVNGHRH-GGDFGIRSTVTFSCDPGYTLSDDEPLVCE---RNHQWNHALPSCD 928
Score = 32.0 bits (71), Expect = 1.7
Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P +I G G + G + YSC P + L GHA ++C V W P C
Sbjct: 145 CGNPGEILKGVLHGTR--FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Score = 32.0 bits (71), Expect = 1.7
Identities = 11/33 (33%), Positives = 16/33 (48%)
Query: 507 VTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
VT CD GY + + + C N W +P C+
Sbjct: 896 VTFSCDPGYTLSDDEPLVCERNHQWNHALPSCD 928
Score = 32.0 bits (71), Expect = 1.7
Identities = 18/75 (24%), Positives = 38/75 (50%), Gaps = 4/75 (5%)
Query: 111 KRCRHPGELRNGQVEIKTD-LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQ 169
K+C+ P + ++ + D G +++ C G+ L+G+ C++ + + + LP
Sbjct: 2257 KKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQ-LQFEGSLPT 2315
Query: 170 CEIVKCKPPPDIRNG 184
CE +C P ++R G
Sbjct: 2316 CE-AQC-PANEVRTG 2328
Score = 31.2 bits (69), Expect = 2.8
Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 6/65 (9%)
Query: 452 YECDKGYILVGQAKLSC-----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPEN 506
+EC+ GY+L G L C + + W+ P C C R ++ Y EP
Sbjct: 1766 FECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPC-SGNFTQRRGTILSPGYPEPYG 1824
Query: 507 VTIQC 511
+ C
Sbjct: 1825 NNLNC 1829
Score = 30.8 bits (68), Expect = 3.7
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 3/29 (10%)
Query: 69 TRFKTGTTLKYTCLPGYV-RSHSTQTLTC 96
TRF G ++Y+CLPGY+ H+ LTC
Sbjct: 159 TRFNIGDKIRYSCLPGYILEGHA--ILTC 185
Score = 30.4 bits (67), Expect = 4.8
Identities = 19/77 (24%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Query: 158 DRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217
D G+ ++VKC+ P G +E + V YSC+P +++ G +++C
Sbjct: 1201 DTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFT-DTVVLYSCNPGYAMHGSNTLTC 1259
Query: 218 TVENETIGVWRPSPPTC 234
+ VW P+C
Sbjct: 1260 LSGDRR--VWDKPLPSC 1274
Score = 30.0 bits (66), Expect = 6.3
Identities = 15/61 (24%), Positives = 29/61 (47%), Gaps = 7/61 (11%)
Query: 177 PPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK 236
P + RH G+ + +VT+SCDP ++L + C ++ W + P+C+
Sbjct: 877 PGIPVNGHRHGGD---FGIRSTVTFSCDPGYTLSDDEPLVCERNHQ----WNHALPSCDA 929
Query: 237 I 237
+
Sbjct: 930 L 930
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 158 bits (400), Expect = 1e-38
Identities = 146/498 (29%), Positives = 213/498 (42%), Gaps = 56/498 (11%)
Query: 67 TETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTF--CIYKRCRHPGELRNGQ 123
++ + GT Y C PGY RS + C GEWV N C + C HPG+ G
Sbjct: 38 SDQTYPEGTQAIYKCRPGY-RSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGT 95
Query: 124 VEIK--TDLSFGSQIEFSCSEGFFLIGSTTSR-CEVQDRGVGWSHPLPQCEIVKCKPPPD 180
+ +G + ++C+EG+ L+G R C+ GW++ +P CE+VKC P
Sbjct: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD----GWTNDIPICEVVKCLPVTA 151
Query: 181 IRNGRHSGE----ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK 236
NG+ + Y +G +V + C+ + + G + C+ + G W P C +
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD----GFWSKEKPKCVE 207
Query: 237 ITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL--RGSSVIHCDADSKWNPSPPAC 294
I+C+ PDV +G +S IY + +KC G+ RG +V +S W P P+C
Sbjct: 208 ISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVC---TESGWRPL-PSC 262
Query: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW 354
E SC N P IP+ + P K + G + Y+C G+ P T T C + W
Sbjct: 263 EEKSCDN-PYIPNGDYS--PLRIK---HRTGDEITYQCRNGFYPAT-RGNTAKC-TSTGW 314
Query: 355 TPYQGCEALCCPEPKLNNGEITQHRKSRP----ANHCVYFYGDEISFSCHETSRFSAI-C 409
P C C P + +G + RP A Y Y + F S + I C
Sbjct: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
Query: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYIL-VGQAKLS 467
DG WSP P C C FP Y Q+ F + + I C GY L Q ++
Sbjct: 375 TQDG-WSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVT 430
Query: 468 CSYSHWSAPAPQCKAL--CRKP--ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQ-- 521
C + WS P P+C + C K ++ NG +S + Y E QC GY +
Sbjct: 431 CMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETS 489
Query: 522 -SITCSGNRTWYPEVPKC 538
SITC G W + P C
Sbjct: 490 GSITC-GKDGWSAQ-PTC 505
Score = 140 bits (353), Expect = 3e-33
Identities = 153/602 (25%), Positives = 225/602 (37%), Gaps = 109/602 (18%)
Query: 44 PAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRS--HSTQTLTCNSDGE 101
P + +C P ++ D T FK TL Y C GY + +T ++ C +G
Sbjct: 503 PTCIKSCDIPVFMNARTKNDFTW----FKLNDTLDYECHDGYESNTGSTTGSIVCGYNG- 557
Query: 102 WVYNTFCIYKRCRHPG-ELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
W C + C P ++ K G ++FSC GF ++G + +C
Sbjct: 558 WSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY----H 613
Query: 161 VGWSHPLPQC--EIVKCKPPPDIRNGRHSGEENFYAYGFS--VTYSCDPRFSLLGHASIS 216
G S LP C ++ C PPP++ NG E+ YG S V Y C+PRF + G I
Sbjct: 614 FGLSPDLPICKEQVQSCGPPPELLNGNVK-EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQ 672
Query: 217 CTVENETIGVWRPSPPTC--EKITCRK-PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL 273
C G W + P C E+ TC P++ HG P Y Y D++ F C + F +
Sbjct: 673 CVD-----GEWT-TLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTM 725
Query: 274 RGSSVIHCDADSKWNPSPPA--------CEPNSCI-------NLPDIPHASWETY----- 313
G I C W P C+ ++ I N + H S Y
Sbjct: 726 IGHRSITC-IHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK 784
Query: 314 ----------------------------PRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTT 345
P P + + + T L YR E +
Sbjct: 785 EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR--------DGEKVS 836
Query: 346 VICQKNL-------------RWTPYQGC--EALCCPEPKLNNGEITQHRKSRPANHCVYF 390
V+CQ+N RW C + C P++ +G I R S+ + Y
Sbjct: 837 VLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQES----YA 892
Query: 391 YGDEISFSCHETSRFSAICQGD---GTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK 447
+G ++S++C R S + G WS G C PP+I+HG S +
Sbjct: 893 HGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYG 952
Query: 448 EEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRK-PELVNG-RLSVDKDQYVEPE 505
EE+ Y+C +G+ + G A C WS P K C P N + KD Y E
Sbjct: 953 EEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGE 1012
Query: 506 NVTIQCDSGYGVVGPQSITCSGNR-TWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPED 564
VT C + Y + G ++TC +R T P P + R M P+ E
Sbjct: 1013 QVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGER 1072
Query: 565 VK 566
V+
Sbjct: 1073 VR 1074
Score = 133 bits (334), Expect = 5e-31
Identities = 119/437 (27%), Positives = 188/437 (43%), Gaps = 63/437 (14%)
Query: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKR---CRHPGELRNGQVEIK 127
F + ++Y C R T +G W C + C P ++ N +
Sbjct: 771 FDHNSNIRYRC-----RGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSH-NMT 824
Query: 128 TDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQC-EIVKCKPPPDIRNG 184
T L++ G ++ C E + + C+ G +P C E + C PP I +G
Sbjct: 825 TTLNYRDGEKVSVLCQENYLIQEGEEITCKD-----GRWQSIPLCVEKIPCSQPPQIEHG 879
Query: 185 R----HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET---IGVWRPSPPTCEKI 237
S +E+ YA+G ++Y+C+ F + + ENET +G W SPP CE +
Sbjct: 880 TINSSRSSQES-YAHGTKLSYTCEGGFRI--------SEENETTCYMGKWS-SPPQCEGL 929
Query: 238 TCRKP-DVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEP 296
C+ P ++SHG +V+ Y Y + + +KC +GF + G ++ C + KW+ PP+C
Sbjct: 930 PCKSPPEISHG-VVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCIK 986
Query: 297 NSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
C++LP +A P K+DVY G + Y C YK D + V C N RWT
Sbjct: 987 TDCLSLPSFENA----IPMGEKKDVYKAGEQVTYTCATYYK--MDGASNVTCI-NSRWTG 1039
Query: 357 YQGC-EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC---HETSRFSAICQGD 412
C + C P + N I + S+ Y G+ + + C +E + +
Sbjct: 1040 RPTCRDTSCVNPPTVQNAYIVSRQMSK------YPSGERVRYQCRSPYEMFGDEEVMCLN 1093
Query: 413 GTWSPRTPSCGDI---CNFPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYILVGQAKLS 467
G W+ P C D C PP I +G S S + + Y+C Y L G +++
Sbjct: 1094 GNWT-EPPQCKDSTGKCGPPPPIDNGDIT-SFPLSVYAPASSVEYQCQNLYQLEGNKRIT 1151
Query: 468 CSYSHWSAPAPQCKALC 484
C WS P P+C C
Sbjct: 1152 CRNGQWSEP-PKCLHPC 1167
Score = 127 bits (319), Expect = 3e-29
Identities = 139/565 (24%), Positives = 217/565 (38%), Gaps = 105/565 (18%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
+CGPPP L + T E + ++Y C P ++ + + C DGEW C
Sbjct: 629 SCGPPPELLNGNVKEKTKEE--YGHSEVVEYYCNPRFLMKGPNK-IQC-VDGEWTTLPVC 684
Query: 109 IYKR--CRHPGELRNGQVEIKTD-LSFGSQIEFSCSEGFFLIGSTTSRC----------- 154
I + C EL +G ++ + +G +EF+CSE F +IG + C
Sbjct: 685 IVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQC 744
Query: 155 ---------------------------------EVQDRGV-GWSH---------PLPQCE 171
+ RG GW H P C
Sbjct: 745 VAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCS 804
Query: 172 IVK---CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWR 228
+ + C PPP I N + Y G V+ C + + I+C G W+
Sbjct: 805 MAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKD-----GRWQ 859
Query: 229 PSPPTCEKITCRKP-DVSHGEMVSGFGP--IYNYKDTIVFKCQKGFVLRGSSVIHCDADS 285
P EKI C +P + HG + S Y + + + C+ GF + + C
Sbjct: 860 SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-G 918
Query: 286 KWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTT 345
KW+ SPP CE C + P+I H D Y G + Y+C G+ D P
Sbjct: 919 KWS-SPPQCEGLPCKSPPEISHGVVAHM-----SDSYQYGEEVTYKCFEGFG--IDGPAI 970
Query: 346 VICQKNLRWTPYQGC-EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC---HE 401
C +W+ C + C P N +K VY G++++++C ++
Sbjct: 971 AKCLGE-KWSHPPSCIKTDCLSLPSFENAIPMGEKKD------VYKAGEQVTYTCATYYK 1023
Query: 402 TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHY--KQSSSYSFFKEEIIYECDKGY 458
S + + W+ R P+C D C PP + + + +Q S Y E + Y+C Y
Sbjct: 1024 MDGASNVTCINSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPS-GERVRYQCRSPY 1081
Query: 459 ILVGQAKLSCSYSHWSAPAPQCKALCRK----PELVNGRL-SVDKDQYVEPENVTIQCDS 513
+ G ++ C +W+ P PQCK K P + NG + S Y +V QC +
Sbjct: 1082 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 1140
Query: 514 GYGVVGPQSITCSGNRTWYPEVPKC 538
Y + G + ITC + + E PKC
Sbjct: 1141 LYQLEGNKRITCRNGQ--WSEPPKC 1163
Score = 121 bits (304), Expect = 2e-27
Identities = 114/456 (25%), Positives = 189/456 (41%), Gaps = 54/456 (11%)
Query: 108 CIYKRCRHPGELRNGQVEIKT--DLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
C+ + C RN ++ + D ++ G+Q + C G+ +G+ C + W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE----W 71
Query: 164 S--HPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
+PL +C+ C P D G + N + YG Y+C+ + LLG + E
Sbjct: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYR---E 128
Query: 221 NETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGF---GPIYNYKDTIVFKCQKGFVLRGS 276
+T G W P CE + C +G++VS Y++ + F C G+ + G
Sbjct: 129 CDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGD 187
Query: 277 SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
+HC D W+ P C SC PD+ + S +++ +Y +Y+C+ GY
Sbjct: 188 EEMHCSDDGFWSKEKPKCVEISC-KSPDVINGS-----PISQKIIYKENERFQYKCNMGY 241
Query: 337 KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHR-KSRPANHCVYFYGDEI 395
+ E +C ++ W P CE C P + NG+ + R K R GDEI
Sbjct: 242 E--YSERGDAVCTES-GWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRT--------GDEI 290
Query: 396 SFSCHE-----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI 450
++ C T +A C G W P C++P G Y ++ +F +
Sbjct: 291 TYQCRNGFYPATRGNTAKCTSTG-WIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAV 349
Query: 451 ----IYECDKGYILVGQA---KLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVE 503
Y CD+ + + + C+ WS PA C C P L NG ++V+
Sbjct: 350 GKYYSYYCDEHFETPSGSYWDHIHCTQDGWS-PAVPCLRKCYFPYLENGYNQNHGRKFVQ 408
Query: 504 PENVTIQCDSGYGVVGPQ-SITCSGNRTWYPEVPKC 538
+++ + C GY + Q ++TC N W P P+C
Sbjct: 409 GKSIDVACHPGYALPKAQTTVTCMEN-GWSP-TPRC 442
Score = 120 bits (300), Expect = 5e-27
Identities = 126/491 (25%), Positives = 190/491 (38%), Gaps = 60/491 (12%)
Query: 50 CGPPPTLSFAAPMDITLTETR-FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
CG P F TLT F+ G YTC GY C++DG C
Sbjct: 85 CGHPGDTPFGT---FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC 141
Query: 109 IYKRCRHPGELRNGQV-----EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
+C NG++ E + FG + F C+ G+ + G C D G W
Sbjct: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGF-W 198
Query: 164 SHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
S P+C + CK PD+ NG ++ Y Y C+ + CT
Sbjct: 199 SKEKPKCVEISCK-SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-- 255
Query: 224 IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPI---YNYKDTIVFKCQKGF--VLRGSSV 278
WRP P+CE+ +C P + +G+ + P+ + D I ++C+ GF RG++
Sbjct: 256 ---WRPL-PSCEEKSCDNPYIPNGD----YSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHAS--WETYPRPTKEDVYVVGTVLRYRCHPGY 336
C + W P+ P C C + PDI H E RP VG Y C +
Sbjct: 308 -KC-TSTGWIPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFP--VAVGKYYSYYCDEHF 361
Query: 337 K-PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
+ P+ + C ++ W+P C C P L NG H + + G I
Sbjct: 362 ETPSGSYWDHIHCTQD-GWSPAVPCLRKCY-FPYLENGYNQNHGRK-------FVQGKSI 412
Query: 396 SFSCH-----ETSRFSAICQGDGTWSPRTPSCGDI--CNFPPKIAHGHYKQSSSYSF-FK 447
+CH ++ + C +G WSP TP C + C+ + S Y++ K
Sbjct: 413 DVACHPGYALPKAQTTVTCMENG-WSP-TPRCIRVKTCSKSSIDIENGFISESQYTYALK 470
Query: 448 EEIIYECDKGYILVG---QAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEP 504
E+ Y+C GY+ ++C WSA P C C P +N R D +
Sbjct: 471 EKAKYQCKLGYVTADGETSGSITCGKDGWSA-QPTCIKSCDIPVFMNARTKNDFTWFKLN 529
Query: 505 ENVTIQCDSGY 515
+ + +C GY
Sbjct: 530 DTLDYECHDGY 540
Score = 108 bits (270), Expect = 1e-23
Identities = 129/512 (25%), Positives = 208/512 (40%), Gaps = 79/512 (15%)
Query: 68 ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEI 126
+ + G +++ C GY + + + C+ DG W C+ C+ P + +
Sbjct: 165 DREYHFGQAVRFVCNSGY-KIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQ 223
Query: 127 KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186
K + ++ C+ G+ + R + GW PLP CE C P I NG +
Sbjct: 224 KIIYKENERFQYKCNMGY----EYSERGDAVCTESGW-RPLPSCEEKSCDNPY-IPNGDY 277
Query: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSH 246
S + G +TY C F A+ T + + G W P+P C C PD+ H
Sbjct: 278 SPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTG-WIPAP-RCTLKPCDYPDIKH 332
Query: 247 GEMVS----------GFGPIYNYKDTIVFKCQKGFVLRGSSV---IHCDADSKWNPSPPA 293
G + G Y+Y C + F S IHC D W+P+ P
Sbjct: 333 GGLYHENMRRPYFPVAVGKYYSYY------CDEHFETPSGSYWDHIHCTQDG-WSPAVPC 385
Query: 294 CEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLR 353
C P + + + + R +V G + CHPGY + TTV C +N
Sbjct: 386 LR--KCY-FPYLENGYNQNHGRK-----FVQGKSIDVACHPGYALPKAQ-TTVTCMEN-G 435
Query: 354 WTPYQGC-EALCCPEPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCH--------ET 402
W+P C C + ++ NG I++ + + Y ++ + C ET
Sbjct: 436 WSPTPRCIRVKTCSKSSIDIENGFISESQYT-------YALKEKAKYQCKLGYVTADGET 488
Query: 403 SRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYIL 460
S S C DG WS + P+C C+ P + + + + +++FK + + YEC GY
Sbjct: 489 SG-SITCGKDG-WSAQ-PTCIKSCDIPVFM---NARTKNDFTWFKLNDTLDYECHDGYES 542
Query: 461 ---VGQAKLSCSYSHWSAPAPQC-KALCRKPELVNGRLSVD--KDQYVEPENVTIQCDSG 514
+ C Y+ WS P C + C P+ ++ L D KDQY E + C G
Sbjct: 543 NTGSTTGSIVCGYNGWS-DLPICYERECELPK-IDVHLVPDRKKDQYKVGEVLKFSCKPG 600
Query: 515 YGVVGPQSITCSGNRTWYPEVPKCEWETPEGC 546
+ +VGP S+ C + P++P C+ E + C
Sbjct: 601 FTIVGPNSVQCY-HFGLSPDLPICK-EQVQSC 630
Score = 100 bits (250), Expect = 3e-21
Identities = 81/320 (25%), Positives = 135/320 (42%), Gaps = 27/320 (8%)
Query: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCI 109
C PP + ++ + GT L YTC G+ S +T TC G+W C
Sbjct: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET-TCYM-GKWSSPPQCE 927
Query: 110 YKRCRHPGELRNGQVEIKTD-LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168
C+ P E+ +G V +D +G ++ + C EGF + G ++C G WSHP P
Sbjct: 928 GLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC----LGEKWSHP-P 982
Query: 169 QCEIVKCKPPPDIRNGRHSGE-ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227
C C P N GE ++ Y G VTY+C + + G ++++C T
Sbjct: 983 SCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWT---- 1038
Query: 228 RPSPPTCEKITC-RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK 286
PTC +C P V + +VS Y + + ++C+ + + G + C +
Sbjct: 1039 --GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN 1095
Query: 287 WNPSPPACEPNS--CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344
W PP C+ ++ C P I + ++P VY + + Y+C Y+ ++
Sbjct: 1096 WT-EPPQCKDSTGKCGPPPPIDNGDITSFPL----SVYAPASSVEYQCQNLYQLEGNKRI 1150
Query: 345 TVICQKNLRWTPYQGCEALC 364
T +N +W+ C C
Sbjct: 1151 TC---RNGQWSEPPKCLHPC 1167
Score = 31.2 bits (69), Expect = 2.8
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)
Query: 449 EIIYECDKGYILVGQAKLSCSYSHWSA--PAPQC-KALCRKP-ELVNGRLSVDKDQYVE- 503
+ IY+C GY +G + C W A P +C K C P + G ++ E
Sbjct: 47 QAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY 106
Query: 504 PENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
C+ GY ++G + W ++P CE
Sbjct: 107 GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE 142
Score = 29.6 bits (65), Expect = 8.2
Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 12/106 (11%)
Query: 48 GNCGPPPTLSFAAPMDIT-LTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT 106
G CGPPP + DIT + + ++++Y C Y + + +TC +G+W
Sbjct: 1107 GKCGPPPPIDNG---DITSFPLSVYAPASSVEYQCQNLY-QLEGNKRITCR-NGQWSEPP 1161
Query: 107 FCIYKRCRHPGELRNGQVEI------KTDLSFGSQIEFSCSEGFFL 146
C++ + N + + K G +EF C G+ L
Sbjct: 1162 KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL 1207
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 154 bits (390), Expect = 2e-37
Identities = 80/198 (40%), Positives = 113/198 (57%), Gaps = 5/198 (2%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHS-TQTLTCNSDGEWVYNT- 106
+C P L+ A+ +T+ F GT ++Y C PGY R S + LTC + +W
Sbjct: 97 SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVE 156
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
FC K C +PGE+RNGQ+++ + FG+ I FSC+ G+ L GST+S C + V WS P
Sbjct: 157 FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
Query: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226
LP+C + C PP I NG GE + Y Y SVTY+C+ F+++G SI CTV N+ G
Sbjct: 217 LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE-GE 275
Query: 227 WRPSPPTC--EKITCRKP 242
W PP C + +T + P
Sbjct: 276 WSGPPPECRGKSLTSKVP 293
Score = 103 bits (256), Expect = 6e-22
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 28/239 (11%)
Query: 260 KDTIV-FKCQKGFVL---RGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+DT++ +KC++ FV SVI C S+W+ C N +P +++ P
Sbjct: 57 EDTVITYKCEESFVKIPGEKDSVI-CLKGSQWSDIEEFC--NRSCEVPTRLNSASLKQPY 113
Query: 316 PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCPEPKLNNGE 374
T ++ + VGTV+ Y C PGY+ + C +NL+W T + C+ CP P GE
Sbjct: 114 IT-QNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNP----GE 168
Query: 375 ITQHRKSRPANHCVYFYGDEISFSCH-------ETSRFSAICQGDGTWSPRTPSCGDI-C 426
I + P +G ISFSC+ TS F I WS P C +I C
Sbjct: 169 IRNGQIDVPGG---ILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYC 225
Query: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH----WSAPAPQCK 481
PP+I +G + + +++ + Y C+KG+ ++G+ + C+ ++ WS P P+C+
Sbjct: 226 PAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 101 bits (252), Expect = 2e-21
Identities = 67/272 (24%), Positives = 118/272 (43%), Gaps = 15/272 (5%)
Query: 36 MTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQ-TL 94
+ L+ LPAV G+CG PP + A P T F T + Y C +V+ + ++
Sbjct: 22 LLLVLLCLPAVWGDCGLPPDVPNAQPA--LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79
Query: 95 TCNSDGEWV-YNTFCIYKRCRHPGELRNGQVE----IKTDLSFGSQIEFSCSEGFFLIGS 149
C +W FC + C P L + ++ + G+ +E+ C G+ S
Sbjct: 80 ICLKGSQWSDIEEFC-NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138
Query: 150 TTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSL 209
+ + + + WS + C+ C P +IRNG+ +G ++++SC+ + L
Sbjct: 139 LSPKLTCL-QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGIL-FGATISFSCNTGYKL 196
Query: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQK 269
G S C + ++ W P C +I C P ++ G Y Y+ ++ + C K
Sbjct: 197 FGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNK 255
Query: 270 GFVLRGSSVIHC---DADSKWNPSPPACEPNS 298
GF + G I+C + + +W+ PP C S
Sbjct: 256 GFTMIGEHSIYCTVNNDEGEWSGPPPECRGKS 287
Score = 79.3 bits (194), Expect = 9e-15
Identities = 65/254 (25%), Positives = 101/254 (39%), Gaps = 28/254 (11%)
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
PD+P+A P + TV+ Y+C + E +VIC K +W+ + C
Sbjct: 40 PDVPNAQ----PALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYF-YGDEISFSCHETSRFSA------ICQGDGT 414
C +LN+ + Q P YF G + + C R C +
Sbjct: 96 RSCEVPTRLNSASLKQ-----PYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150
Query: 415 WSPRTPSCGD-ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-- 471
WS C C P +I +G F I + C+ GY L G C S
Sbjct: 151 WSTAVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSFCLISGS 209
Query: 472 --HWSAPAPQCKALC--RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSG 527
WS P P+C+ + P++ NG + ++D Y ++VT C+ G+ ++G SI C+
Sbjct: 210 SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
Query: 528 NR---TWYPEVPKC 538
N W P+C
Sbjct: 270 NNDEGEWSGPPPEC 283
Score = 46.2 bits (108), Expect = 9e-05
Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 12/186 (6%)
Query: 364 CCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCG 423
C P + N + ++ V Y E SF + S IC WS C
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 424 DICNFPPKIAHGHYKQ---SSSYSFFKEEIIYECDKGYILVG--QAKLSCSYS-HWSAPA 477
C P ++ KQ + +Y + YEC GY KL+C + WS
Sbjct: 96 RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAV 155
Query: 478 PQC-KALCRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRT-WY 532
C K C P E+ NG++ V + ++ C++GY + G S C SG+ W
Sbjct: 156 EFCKKKSCPNPGEIRNGQIDV-PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
Query: 533 PEVPKC 538
+P+C
Sbjct: 215 DPLPEC 220
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 154 bits (390), Expect = 2e-37
Identities = 80/198 (40%), Positives = 113/198 (57%), Gaps = 5/198 (2%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHS-TQTLTCNSDGEWVYNT- 106
+C P L+ A+ +T+ F GT ++Y C PGY R S + LTC + +W
Sbjct: 97 SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVE 156
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
FC K C +PGE+RNGQ+++ + FG+ I FSC+ G+ L GST+S C + V WS P
Sbjct: 157 FCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
Query: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226
LP+C + C PP I NG GE + Y Y SVTY+C+ F+++G SI CTV N+ G
Sbjct: 217 LPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE-GE 275
Query: 227 WRPSPPTC--EKITCRKP 242
W PP C + +T + P
Sbjct: 276 WSGPPPECRGKSLTSKVP 293
Score = 103 bits (256), Expect = 6e-22
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 28/239 (11%)
Query: 260 KDTIV-FKCQKGFVL---RGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPR 315
+DT++ +KC++ FV SVI C S+W+ C N +P +++ P
Sbjct: 57 EDTVITYKCEESFVKIPGEKDSVI-CLKGSQWSDIEEFC--NRSCEVPTRLNSASLKQPY 113
Query: 316 PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCPEPKLNNGE 374
T ++ + VGTV+ Y C PGY+ + C +NL+W T + C+ CP P GE
Sbjct: 114 IT-QNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNP----GE 168
Query: 375 ITQHRKSRPANHCVYFYGDEISFSCH-------ETSRFSAICQGDGTWSPRTPSCGDI-C 426
I + P +G ISFSC+ TS F I WS P C +I C
Sbjct: 169 IRNGQIDVPGG---ILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYC 225
Query: 427 NFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH----WSAPAPQCK 481
PP+I +G + + +++ + Y C+KG+ ++G+ + C+ ++ WS P P+C+
Sbjct: 226 PAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 101 bits (252), Expect = 2e-21
Identities = 67/272 (24%), Positives = 118/272 (43%), Gaps = 15/272 (5%)
Query: 36 MTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQ-TL 94
+ L+ LPAV G+CG PP + A P T F T + Y C +V+ + ++
Sbjct: 22 LLLVLLCLPAVWGDCGLPPDVPNAQPA--LEGRTSFPEDTVITYKCEESFVKIPGEKDSV 79
Query: 95 TCNSDGEWV-YNTFCIYKRCRHPGELRNGQVE----IKTDLSFGSQIEFSCSEGFFLIGS 149
C +W FC + C P L + ++ + G+ +E+ C G+ S
Sbjct: 80 ICLKGSQWSDIEEFC-NRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPS 138
Query: 150 TTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSL 209
+ + + + WS + C+ C P +IRNG+ +G ++++SC+ + L
Sbjct: 139 LSPKLTCL-QNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGIL-FGATISFSCNTGYKL 196
Query: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQK 269
G S C + ++ W P C +I C P ++ G Y Y+ ++ + C K
Sbjct: 197 FGSTSSFCLISGSSVQ-WSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNK 255
Query: 270 GFVLRGSSVIHC---DADSKWNPSPPACEPNS 298
GF + G I+C + + +W+ PP C S
Sbjct: 256 GFTMIGEHSIYCTVNNDEGEWSGPPPECRGKS 287
Score = 79.3 bits (194), Expect = 9e-15
Identities = 65/254 (25%), Positives = 101/254 (39%), Gaps = 28/254 (11%)
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
PD+P+A P + TV+ Y+C + E +VIC K +W+ + C
Sbjct: 40 PDVPNAQ----PALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYF-YGDEISFSCHETSRFSA------ICQGDGT 414
C +LN+ + Q P YF G + + C R C +
Sbjct: 96 RSCEVPTRLNSASLKQ-----PYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150
Query: 415 WSPRTPSCGD-ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-- 471
WS C C P +I +G F I + C+ GY L G C S
Sbjct: 151 WSTAVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSFCLISGS 209
Query: 472 --HWSAPAPQCKALC--RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSG 527
WS P P+C+ + P++ NG + ++D Y ++VT C+ G+ ++G SI C+
Sbjct: 210 SVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTV 269
Query: 528 NR---TWYPEVPKC 538
N W P+C
Sbjct: 270 NNDEGEWSGPPPEC 283
Score = 46.2 bits (108), Expect = 9e-05
Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 12/186 (6%)
Query: 364 CCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCG 423
C P + N + ++ V Y E SF + S IC WS C
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 424 DICNFPPKIAHGHYKQ---SSSYSFFKEEIIYECDKGYILVG--QAKLSCSYS-HWSAPA 477
C P ++ KQ + +Y + YEC GY KL+C + WS
Sbjct: 96 RSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAV 155
Query: 478 PQC-KALCRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRT-WY 532
C K C P E+ NG++ V + ++ C++GY + G S C SG+ W
Sbjct: 156 EFCKKKSCPNPGEIRNGQIDV-PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
Query: 533 PEVPKC 538
+P+C
Sbjct: 215 DPLPEC 220
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 151 bits (382), Expect = 1e-36
Identities = 136/490 (27%), Positives = 195/490 (39%), Gaps = 54/490 (11%)
Query: 68 ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELR---NGQV 124
ET+++ L C PGY + + + C ++G+W R GEL NG
Sbjct: 2611 ETQYQFQAQLMLICDPGYYYT-GQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGH- 2668
Query: 125 EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNG 184
I T +G+ FSC+ G+ L+GS C WS +C C P I NG
Sbjct: 2669 RIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL---WSGSEVRCLAGHCGTPEPIVNG 2725
Query: 185 RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV 244
+GE Y+Y SV Y C+ F L+G + C ++ W P C ++C P
Sbjct: 2726 HINGEN--YSYRGSVVYQCNAGFRLIGMSVRICQQDHH----WSGKTPFCVLVSCGHPGS 2779
Query: 245 SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSC--INL 302
+SG Y + + C L G+S C D W S P C S
Sbjct: 2780 PPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGD 2837
Query: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CE 361
P IP D + GTV+R+ C G+ T CQ N W+ Q C
Sbjct: 2838 PGIPAHGIRL------GDSFDPGTVMRFSCEAGHVLRGSSERT--CQANGSWSGSQPECG 2889
Query: 362 ALCCPEPKLNNGEITQHRKSRPANHCVYF-----YGDEISFSCHE----TSRFSAICQGD 412
+ C P P+N V F + I + C E T S C +
Sbjct: 2890 VISCGNP------------GTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVN 2937
Query: 413 GTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQ--AKLSCSY 470
GTW+ P C I P I + + + + K + Y+C GY++ + LSC+
Sbjct: 2938 GTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKT-VTYQCVPGYMMESHRVSVLSCTK 2996
Query: 471 SH-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGN 528
W+ P CKAL C+ P L+ V D ++ +VT C GY + P TC GN
Sbjct: 2997 DRTWNGTKPVCKALMCKPPPLIPNGKVVGSD-FMWGSSVTYACLEGYQLSLPAVFTCEGN 3055
Query: 529 RTWYPEVPKC 538
+W E+P+C
Sbjct: 3056 GSWTGELPQC 3065
Score = 151 bits (382), Expect = 1e-36
Identities = 122/517 (23%), Positives = 208/517 (40%), Gaps = 54/517 (10%)
Query: 48 GNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT- 106
G+CG P + ++ + + ++ Y C G+ R C D W T
Sbjct: 2714 GHCGTPEPI-----VNGHINGENYSYRGSVVYQCNAGF-RLIGMSVRICQQDHHWSGKTP 2767
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
FC+ C HPG + Q+ + G+ + +SC L+G++T C + W+
Sbjct: 2768 FCVLVSCGHPGSPPHSQMS-GDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGH---WTGS 2823
Query: 167 LPQCE---IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
LP C + C P +G G+ + G + +SC+ L G + +C
Sbjct: 2824 LPHCSGTSVGVCGDPGIPAHGIRLGDS--FDPGTVMRFSCEAGHVLRGSSERTCQAN--- 2878
Query: 224 IGVWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD 282
G W S P C I+C P S+ +V G +++ +IV++C++G+ G HC
Sbjct: 2879 -GSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFS--SSIVYECREGYYATGLLSRHCS 2935
Query: 283 ADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342
+ W S P C +C + P IP + + + Y+C PGY +
Sbjct: 2936 VNGTWTGSDPECLVINCGD-PGIPANGLRL------GNDFRYNKTVTYQCVPGYMMESHR 2988
Query: 343 PTTVICQKNLRWTPYQG-CEALCC-PEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
+ + C K+ W + C+AL C P P + NG++ + +G ++++C
Sbjct: 2989 VSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSD---------FMWGSSVTYACL 3039
Query: 401 ETSRFSA----ICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDK 456
E + S C+G+G+W+ P C + P + ++ +S+ + + + C
Sbjct: 3040 EGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSY-RSSVSFSCHP 3098
Query: 457 GYILVGQAKLSC-SYSHWSAPAPQC----KALCRKPELVNGRLSVDKDQYVEPENVTIQC 511
+LVG + C S WS P C C P + + + Y V +C
Sbjct: 3099 PLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRC 3158
Query: 512 DSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548
GY + G + TC N TW P C P C Q
Sbjct: 3159 QKGYLLQGSTTRTCLPNLTWSGTPPDC---VPHHCRQ 3192
Score = 139 bits (349), Expect = 1e-32
Identities = 126/453 (27%), Positives = 177/453 (39%), Gaps = 59/453 (13%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQCE 171
C P +G + +T G I F C+ G+ L+G + + C +G WS +P C+
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ 2527
Query: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW--RP 229
+ C P +NG G+E Y G YSC + L A T E G+W R
Sbjct: 2528 ALSCGLPEAPKNGMVFGKE--YTVGTKAMYSCSEGYHL--QAGAEATAECLDTGLWSNRN 2583
Query: 230 SPPTCEKITCRKPDVS-----HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDAD 284
PP C +TC PDVS HG F Y ++ ++ C G+ G VI C A+
Sbjct: 2584 VPPQCVPVTC--PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQAN 2641
Query: 285 SKWN--PSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342
KW+ S P C SC LP P+ R VY G + C+ GY T
Sbjct: 2642 GKWSLGDSTPTCRIISCGELPIPPNGH-----RIGTLSVY--GATAIFSCNSGY--TLVG 2692
Query: 343 PTTVICQKNLRWTPYQGCEALC------CPEPKLNNGEITQHRKSRPANHCVYFYGDEIS 396
C N W+ G E C PEP + NG I Y Y +
Sbjct: 2693 SRVRECMANGLWS---GSEVRCLAGHCGTPEP-IVNGHINGEN---------YSYRGSVV 2739
Query: 397 FSCHETSRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEII 451
+ C+ R ICQ D WS +TP C + C P H Q S S+ ++
Sbjct: 2740 YQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPH---SQMSGDSYTVGAVV 2796
Query: 452 -YECDKGYILVGQAKLSCSY-SHWSAPAPQCK----ALCRKPELVNGRLSVDKDQYVEPE 505
Y C LVG + C HW+ P C +C P + + + D +
Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLG-DSFDPGT 2855
Query: 506 NVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ C++G+ + G TC N +W P+C
Sbjct: 2856 VMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC 2888
Score = 124 bits (312), Expect = 2e-28
Identities = 94/315 (29%), Positives = 142/315 (45%), Gaps = 34/315 (10%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYV-RSHSTQTLTCNSDGEWV-YNT 106
NCG P P + F+ T+ Y C+PGY+ SH L+C D W
Sbjct: 2951 NCGDP-----GIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKP 3005
Query: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166
C C+ P + NG+V + +D +GS + ++C EG+ L CE W+
Sbjct: 3006 VCKALMCKPPPLIPNGKV-VGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNG---SWTGE 3061
Query: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226
LPQC V C P GR E+ ++Y SV++SC P L+G C ++ G
Sbjct: 3062 LPQCFPVFCGDPGVPSRGRR--EDRGFSYRSSVSFSCHPPLVLVGSPRRFC----QSDGT 3115
Query: 227 WRPSPPTC---EKITCRKPDVSH-GEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD 282
W + P+C TC P V G + G Y T++F+CQKG++L+GS+ C
Sbjct: 3116 WSGTQPSCIDPTLTTCADPGVPQFGIQNNSQG--YQVGSTVLFRCQKGYLLQGSTTRTCL 3173
Query: 283 ADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY--KPTT 340
+ W+ +PP C P+ C P+ P T+ D+ +G L Y C G+ K +
Sbjct: 3174 PNLTWSGTPPDCVPHHC-RQPETP-----THANVGALDLPSMGYTLIYSCQEGFSLKGGS 3227
Query: 341 DEPTTVICQKNLRWT 355
+ T C+ + WT
Sbjct: 3228 EHRT---CKADGSWT 3239
Score = 114 bits (285), Expect = 3e-25
Identities = 104/390 (26%), Positives = 163/390 (41%), Gaps = 46/390 (11%)
Query: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLT--CNSDGEWV-YN 105
+CG P T S A + +++ Y C GY ++T L+ C+ +G W +
Sbjct: 2892 SCGNPGTPSNAR----VVFSDGLVFSSSIVYECREGY---YATGLLSRHCSVNGTWTGSD 2944
Query: 106 TFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWS 164
C+ C PG NG + + D + + + C G+ + S +DR W+
Sbjct: 2945 PECLVINCGDPGIPANG-LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRT--WN 3001
Query: 165 HPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
P C+ + CKPPP I NG+ G + + +G SVTY+C + L A +C E
Sbjct: 3002 GTKPVCKALMCKPPPLIPNGKVVGSD--FMWGSSVTYACLEGYQLSLPAVFTC----EGN 3055
Query: 225 GVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDAD 284
G W P C + C P V G ++Y+ ++ F C VL GS C +D
Sbjct: 3056 GSWTGELPQCFPVFCGDPGVPSRGRREDRG--FSYRSSVSFSCHPPLVLVGSPRRFCQSD 3113
Query: 285 SKWNPSPPAC-EPN--SCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTD 341
W+ + P+C +P +C + P +P + Y VG+ + +RC GY
Sbjct: 3114 GTWSGTQPSCIDPTLTTCAD-PGVPQFGIQN-----NSQGYQVGSTVLFRCQKGY--LLQ 3165
Query: 342 EPTTVICQKNLRW--TPYQGCEALCCPEPKL----NNGEITQHRKSRPANHCVYFYGDEI 395
TT C NL W TP C C +P+ N G + P+ Y +
Sbjct: 3166 GSTTRTCLPNLTWSGTP-PDCVPHHCRQPETPTHANVGAL-----DLPSMGYTLIYSCQE 3219
Query: 396 SFSCHETSRFSAICQGDGTWSPRTPSCGDI 425
FS S C+ DG+W+ + P C ++
Sbjct: 3220 GFSLKGGSEHRT-CKADGSWTGKPPICLEV 3248
Score = 53.1 bits (126), Expect = 7e-07
Identities = 113/492 (22%), Positives = 185/492 (37%), Gaps = 73/492 (14%)
Query: 95 TCNSDGEWVYN-TFCIYKR--CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFF-LIGST 150
T +S G+ +N TF ++ C PG NG+ L GS I F C EGF GS
Sbjct: 670 TDHSTGKRGFNITFTTFRHNECPDPGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSE 728
Query: 151 TSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR--HSGEENFYAYGFSVTY--SCDPR 206
T C +++ V W+ + +CE C +G G FY S + P
Sbjct: 729 TITCVLKEGSVVWNSAVLRCE-APCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPG 787
Query: 207 FSL-LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVF 265
+ + + V +T+ V + I V HG V F ++
Sbjct: 788 YPIKITFDRFKTEVNYDTLEVRDGRTYSAPLI-----GVYHGTQVPQF---------LIS 833
Query: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVG 325
++L + H D + + + C++ P IP + D Y VG
Sbjct: 834 TSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLD-PGIP-----VNGQRHGNDFY-VG 886
Query: 326 TVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQ--HRKSR 382
++ + C GY + EP + C+ N +W+ CEALC + ++G I
Sbjct: 887 ALVTFSCDSGYTLSDGEP--LECEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFY 944
Query: 383 PAN-HCVYF----YGDEISFSCH----ETSRFSAICQGDGTWS-PRTPSCGDICNFPPKI 432
P N +C + +G + F+ H E+ + +G+++ P G P I
Sbjct: 945 PNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGS--RLPAPI 1002
Query: 433 AHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNG 492
+ G Y F ++ + D G + ++S + C +PE+
Sbjct: 1003 SAG------LYGNFTAQVRFISDFSMSYEG---FNITFSEYDLEP------CEEPEV--P 1045
Query: 493 RLSVDKD-QYVEPENVTIQCDSGYGVVGPQSITCSG--NRTWYPEVPKCEWETPEGCEQV 549
S+ K Q+ + +T C GY + G ITC G R W +P+C E C
Sbjct: 1046 AYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAE----CGNS 1101
Query: 550 LTGKRLMQCLPN 561
+TG + PN
Sbjct: 1102 VTGTQGTLLSPN 1113
Score = 50.1 bits (118), Expect = 6e-06
Identities = 26/60 (43%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P +NG SG+ + G S + CDP ++L G A ISC V+ E W+PSPPTC
Sbjct: 1385 CNDPGIPQNGSRSGDS--WEAGDSTVFQCDPGYALQGSAEISC-VKIENRFFWQPSPPTC 1441
Score = 45.1 bits (105), Expect = 2e-04
Identities = 58/274 (21%), Positives = 95/274 (34%), Gaps = 48/274 (17%)
Query: 111 KRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQC 170
+ C P NG V + G + F C G+ L G C+ W HPLP+C
Sbjct: 2121 QECPDPEPFANGIVR-GAGYNVGQSVTFECLPGYQLTGHPVLTCQ-HGTNRNWDHPLPKC 2178
Query: 171 EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLL-----GH------ASISCTV 219
E V C NG Y+ GF YS L GH + +
Sbjct: 2179 E-VPCGGNITSSNG------TVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP 2231
Query: 220 ENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVI 279
+ I +W T ++ ++ + S + ++ K + G I
Sbjct: 2232 SGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSS-------SNQVLLKFHRDAATGGIFAI 2284
Query: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPT 339
A PP PN+ + T+ + + +G ++RYRC PG+
Sbjct: 2285 AFSAYPLTKCPPPTILPNAEV---------------VTENEEFNIGDIVRYRCLPGFTLV 2329
Query: 340 TDEPTTVICQKNLRWTPYQGCEALC---CPEPKL 370
+E ++ K + ++G +C CP +L
Sbjct: 2330 GNE---ILTCKLGTYLQFEGPPPICEVHCPTNEL 2360
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEV-QDRGVGWSHPLPQC 170
C +PG L NG ++ + + G ++ +SC+ GFFL G C + W PLP C
Sbjct: 139 CGNPGRLPNG-IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Score = 44.3 bits (103), Expect = 3e-04
Identities = 65/279 (23%), Positives = 94/279 (33%), Gaps = 75/279 (26%)
Query: 238 TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC---DADSKWNPSPPAC 294
+C P + SG + D+ VF+C G+ L+GS+ I C + W PSPP C
Sbjct: 1384 SCNDPGIPQNGSRSGDS--WEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
Query: 295 ---------EPNSCINLPDIPHASWETYP-------RPTKEDVYVVGTVLR-YRCHPGYK 337
P+ I P+ P E YP + T YV+ V + PGY
Sbjct: 1442 IAPCGGDLTGPSGVILSPNYP----EPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYD 1497
Query: 338 PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISF 397
Y G ++L P + + FYG ++
Sbjct: 1498 ---------------FLHIYDGRDSL---SPLIGS-----------------FYGSQLPG 1522
Query: 398 SCHETS-------RFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI 450
+S R A G T + + C P I +G + S +
Sbjct: 1523 RIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNG--TRVGSDLKLGSSV 1580
Query: 451 IYECDKGYILVGQAKLSCSYSH-----WSAPAPQCKALC 484
Y C GY + G + LSC W+ P P C A C
Sbjct: 1581 TYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPC 1619
Score = 43.9 bits (102), Expect = 4e-04
Identities = 54/223 (24%), Positives = 84/223 (37%), Gaps = 67/223 (30%)
Query: 70 RFKTGTTLKYTCLPGYVRSHSTQTLTC--------------------------------- 96
+F G TL ++C PGY R T +TC
Sbjct: 1054 QFGVGDTLTFSCFPGY-RLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSP 1112
Query: 97 NSDGEWVYNTFCIYKRCRHPGELRNGQVEIKT---DLSFGSQIE--------------FS 139
N + N CIY PG+ +++K +LS G ++ FS
Sbjct: 1113 NFPVNYNNNHECIYSIQTQPGK----GIQLKARAFELSEGDVLKVYDGNNNSARLLGVFS 1168
Query: 140 CSEGFFLIGSTTSRC-------EVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENF 192
SE + ++TS + ++ G+ E++KC+ P + G +E
Sbjct: 1169 HSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGH 1228
Query: 193 YAYGFSVTYSCDPRFSLLGHASISC-TVENETIGVWRPSPPTC 234
+A G SV++SCDP +SL G + C + E T W PTC
Sbjct: 1229 FA-GSSVSFSCDPGYSLRGSEELLCLSGERRT---WDRPLPTC 1267
Score = 43.9 bits (102), Expect = 4e-04
Identities = 63/292 (21%), Positives = 111/292 (38%), Gaps = 62/292 (21%)
Query: 238 TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADS--KWNPSPPAC- 294
+C +P V + +G + N D + F+C+ G+ L+G + I C + +WN PP C
Sbjct: 1908 SCPEPAVPSNGVKTGERYLVN--DVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965
Query: 295 --------EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTV 346
E I P P YP + + + + + H + + EP
Sbjct: 1966 AQCGGTVEEMEGVILSPGFP----GNYP-SNMDCSWKIALPVGFGAHIQFLNFSTEPNHD 2020
Query: 347 ICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGD------------- 393
+ +R PY+ + + + E+ S VYF+ D
Sbjct: 2021 YIE--IRNGPYETSRMM----GRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Query: 394 EISFSCHETSRF------SAICQGDGT--------WSPRTPSCG----DICNFPPKIAHG 435
++++S H+ S F S + + + T W P C C P A+G
Sbjct: 2075 DLTYS-HQISSFLRGFDLSELERTNSTPPVAASYVWD-LDPGCEAYELQECPDPEPFANG 2132
Query: 436 HYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS---HWSAPAPQCKALC 484
+ + Y+ + + +EC GY L G L+C + +W P P+C+ C
Sbjct: 2133 -IVRGAGYN-VGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC 2182
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 110 YKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRC-EVQDRGVGWSHPLP 168
+ C PG G+ + +D GS ++F+C+EG+ L GS C +V D WS P
Sbjct: 340 HNMCPDPGIPERGK-RLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398
Query: 169 QCEIVKC 175
C C
Sbjct: 399 VCRARMC 405
Score = 39.7 bits (91), Expect = 0.008
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 16/79 (20%)
Query: 254 GPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---------EPNSCINLPD 304
G +++ DT+ F+CQ F L G I C +++W+ P C P+ + P+
Sbjct: 534 GSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPN 593
Query: 305 IP-------HASWETYPRP 316
P H W RP
Sbjct: 594 YPEDYGNHLHCVWLILARP 612
Score = 39.7 bits (91), Expect = 0.008
Identities = 22/60 (36%), Positives = 29/60 (48%), Gaps = 4/60 (6%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P NG +GE Y V++ C+P ++L GHA ISC T+ W PP C
Sbjct: 1909 CPEPAVPSNGVKTGER--YLVNDVVSFQCEPGYALQGHAHISCM--PGTVRRWNYPPPLC 1964
Score = 38.9 bits (89), Expect = 0.014
Identities = 18/68 (26%), Positives = 31/68 (45%), Gaps = 2/68 (2%)
Query: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226
+P+ +C P+ R G+ G + ++ G V + C+ ++L G I C +
Sbjct: 1727 VPRTSATQCSSVPEPRYGKRLGSD--FSVGAIVRFECNSGYALQGSPEIECLPVPGALAQ 1784
Query: 227 WRPSPPTC 234
W S PTC
Sbjct: 1785 WNVSAPTC 1792
Score = 37.7 bits (86), Expect = 0.030
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 11/88 (12%)
Query: 171 EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPS 230
E+ +C P NG G Y G SVT+ C P + L GH ++C ++ T W
Sbjct: 2119 ELQECPDPEPFANGIVRGAG--YNVGQSVTFECLPGYQLTGHPVLTC--QHGTNRNWDHP 2174
Query: 231 PPTCEKITCRKPDVSHGEMVSGFGPIYN 258
P CE + C G + S G +Y+
Sbjct: 2175 LPKCE-VPC------GGNITSSNGTVYS 2195
Score = 36.2 bits (82), Expect = 0.088
Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P + NG G + G V YSC+ F L GHA ++C +E W P+C
Sbjct: 139 CGNPGRLPNGIQQGST--FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Score = 36.2 bits (82), Expect = 0.088
Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 2/60 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P I+NG G + G SVTY C + + G +++SC + + VW P C
Sbjct: 1558 CFDPGSIKNGTRVGSD--LKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC 1615
Score = 35.0 bits (79), Expect = 0.20
Identities = 18/62 (29%), Positives = 34/62 (54%), Gaps = 7/62 (11%)
Query: 426 CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-----SYSHWSAPAPQC 480
C P ++ +G +Q S+++ +++ Y C+ G+ L G A L+C + + W P P C
Sbjct: 139 CGNPGRLPNG-IQQGSTFNL-GDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Query: 481 KA 482
+A
Sbjct: 197 RA 198
Score = 34.3 bits (77), Expect = 0.33
Identities = 19/74 (25%), Positives = 31/74 (41%), Gaps = 6/74 (8%)
Query: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
+G+ + E C P GR G + +G ++ + C P F L+G +I+C
Sbjct: 507 LGFKASYEEIEQGSCGDPGIPAYGRREGSR--FHHGDTLKFECQPAFELVGQKAITCQKN 564
Query: 221 NETIGVWRPSPPTC 234
N+ W P C
Sbjct: 565 NQ----WSAKKPGC 574
Score = 34.3 bits (77), Expect = 0.33
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 232 PTCEKIT---CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD--ADSK 286
P CE C P+ +V G G YN ++ F+C G+ L G V+ C +
Sbjct: 2113 PGCEAYELQECPDPEPFANGIVRGAG--YNVGQSVTFECLPGYQLTGHPVLTCQHGTNRN 2170
Query: 287 WNPSPPACE 295
W+ P CE
Sbjct: 2171 WDHPLPKCE 2179
Score = 33.9 bits (76), Expect = 0.44
Identities = 20/63 (31%), Positives = 30/63 (47%), Gaps = 10/63 (15%)
Query: 238 TCRKPDVSHGEMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK----WNPSP 291
TC P G + +G G +N D + + C GF L G +V+ C A S+ W+
Sbjct: 138 TCGNP----GRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPL 193
Query: 292 PAC 294
P+C
Sbjct: 194 PSC 196
Score = 33.9 bits (76), Expect = 0.44
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 448 EEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVE 503
+ +++CD GY L G A++SC + W P C A C +L + Y E
Sbjct: 1405 DSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPC-GGDLTGPSGVILSPNYPE 1463
Query: 504 PENVTIQCD 512
P +CD
Sbjct: 1464 PYPPGKECD 1472
Score = 33.5 bits (75), Expect = 0.57
Identities = 16/65 (24%), Positives = 26/65 (40%), Gaps = 2/65 (3%)
Query: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234
C P G+ G + + G SV ++C+ + L G I+C ++ W P C
Sbjct: 343 CPDPGIPERGKRLGSD--FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVC 400
Query: 235 EKITC 239
C
Sbjct: 401 RARMC 405
Score = 33.5 bits (75), Expect = 0.57
Identities = 52/244 (21%), Positives = 76/244 (31%), Gaps = 64/244 (26%)
Query: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC----DADSKWNPSPPACE-- 295
PD E G + ++ F C +G+ L+GS I C D + W+ P C
Sbjct: 344 PDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAR 403
Query: 296 --------PNSCINLPDIP-------HASW---------------ETYPRPTKEDVYVVG 325
P+ I P+ P H W E + D VG
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVG 463
Query: 326 ---------TVLRYRCHPGYKPT-TDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEI 375
TVL Y T T P ++ + W +Q + K + EI
Sbjct: 464 DGGQDGDQKTVL-------YILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEI 516
Query: 376 TQHRKSRPA-------NHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSCGD 424
Q P + +GD + F C + + CQ + WS + P C
Sbjct: 517 EQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVF 576
Query: 425 ICNF 428
C F
Sbjct: 577 SCFF 580
Score = 33.5 bits (75), Expect = 0.57
Identities = 17/51 (33%), Positives = 20/51 (39%), Gaps = 3/51 (5%)
Query: 437 YKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH---WSAPAPQCKALC 484
YK F + + CD GY L G +L C W P P C A C
Sbjct: 1221 YKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAEC 1271
Score = 33.1 bits (74), Expect = 0.75
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 7/65 (10%)
Query: 421 SCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQ 479
SCGD P A+G ++ S + + +EC + LVGQ ++C ++ WSA P
Sbjct: 520 SCGD----PGIPAYG--RREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPG 573
Query: 480 CKALC 484
C C
Sbjct: 574 CVFSC 578
Score = 33.1 bits (74), Expect = 0.75
Identities = 55/251 (21%), Positives = 87/251 (34%), Gaps = 28/251 (11%)
Query: 324 VGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSR 382
VG L + C PGY+ T + + W+ P C A C G + +
Sbjct: 1057 VGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLS--PNF 1114
Query: 383 PANH-----CVYFYGDEISFSCHETSRFSAICQGD--GTWSPRTPSCGDICNFPPKIAHG 435
P N+ C+Y + +R + +GD + S + F G
Sbjct: 1115 PVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMG 1174
Query: 436 HYKQSSSYSFFKEEII--YECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGR 493
S+S S + + I KG+ L H+S+ C P
Sbjct: 1175 VTLNSTSSSLWLDFITDAENTSKGFEL-----------HFSSFE---LIKCEDPGTPKFG 1220
Query: 494 LSVDKDQYVEPENVTIQCDSGYGVVGPQSITC-SG-NRTWYPEVPKCEWETPEGCEQVLT 551
V + + +V+ CD GY + G + + C SG RTW +P C E ++
Sbjct: 1221 YKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVS 1280
Query: 552 GKRLMQCLPNP 562
G+ L P P
Sbjct: 1281 GQVLSPGYPAP 1291
Score = 33.1 bits (74), Expect = 0.75
Identities = 20/73 (27%), Positives = 34/73 (46%), Gaps = 7/73 (9%)
Query: 226 VWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC---- 281
V++ P T P+ +G+ + G ++ + F+C G+ L+GS I C
Sbjct: 1723 VYQAVPRTSATQCSSVPEPRYGKRL---GSDFSVGAIVRFECNSGYALQGSPEIECLPVP 1779
Query: 282 DADSKWNPSPPAC 294
A ++WN S P C
Sbjct: 1780 GALAQWNVSAPTC 1792
Score = 33.1 bits (74), Expect = 0.75
Identities = 58/264 (21%), Positives = 82/264 (31%), Gaps = 68/264 (25%)
Query: 292 PACEPNSCINLPDIPHASWETYPRPTKEDV-----YVVGTVLRYRCHPGYKPTTDEPTTV 346
P CE PD P P + Y VG + + C PGY+ T T
Sbjct: 2113 PGCEAYELQECPD---------PEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTC 2163
Query: 347 ICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRP---ANHCVYF------YGDEIS 396
N W P CE C +NG + P + CV+ +G ++
Sbjct: 2164 QHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLN 2223
Query: 397 FSCHETSR---FSAICQGDGTWSPRT--------------------------PSCGDICN 427
S +T F I G +PR + G I
Sbjct: 2224 LSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFA 2283
Query: 428 F-----------PPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSC---SYSH 472
PP I + + F +I+ Y C G+ LVG L+C +Y
Sbjct: 2284 IAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQ 2343
Query: 473 WSAPAPQCKALCRKPELVNGRLSV 496
+ P P C+ C EL+ V
Sbjct: 2344 FEGPPPICEVHCPTNELLTDSTGV 2367
Score = 31.2 bits (69), Expect = 2.8
Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 6/65 (9%)
Query: 452 YECDKGYILVGQAKLSC-----SYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPEN 506
+EC+ GY L G ++ C + + W+ AP C C L R ++ + EP
Sbjct: 1759 FECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPC-GGNLTERRGTILSPGFPEPYL 1817
Query: 507 VTIQC 511
++ C
Sbjct: 1818 NSLNC 1822
Score = 30.4 bits (67), Expect = 4.8
Identities = 10/34 (29%), Positives = 18/34 (52%)
Query: 505 ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
+ + +C + +VG ++ITC N W + P C
Sbjct: 541 DTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 30.0 bits (66), Expect = 6.3
Identities = 13/43 (30%), Positives = 18/43 (41%), Gaps = 3/43 (6%)
Query: 499 DQYVEPENVTIQCDSGYGVVGPQSITC---SGNRTWYPEVPKC 538
D + ++ QCD GY + G I+C W P P C
Sbjct: 1399 DSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 146 bits (368), Expect = 6e-35
Identities = 127/433 (29%), Positives = 187/433 (43%), Gaps = 47/433 (10%)
Query: 67 TETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTF--CIYKRCRHPGELRNGQ 123
++ + GT Y C PGY RS + C GEWV N C + C HPG+ G
Sbjct: 38 SDQTYPEGTQAIYKCRPGY-RSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGT 95
Query: 124 VEIK--TDLSFGSQIEFSCSEGFFLIGSTTSR-CEVQDRGVGWSHPLPQCEIVKCKPPPD 180
+ +G + ++C+EG+ L+G R C+ GW++ +P CE+VKC P
Sbjct: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD----GWTNDIPICEVVKCLPVTA 151
Query: 181 IRNGRHSGE----ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK 236
NG+ + Y +G +V + C+ + + G + C+ + G W P C +
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD----GFWSKEKPKCVE 207
Query: 237 ITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL--RGSSVIHCDADSKWNPSPPAC 294
I+C+ PDV +G +S IY + +KC G+ RG +V +S W P P+C
Sbjct: 208 ISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVC---TESGWRPL-PSC 262
Query: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW 354
E SC N P IP+ + P K + G + Y+C G+ P T T C + W
Sbjct: 263 EEKSCDN-PYIPNGDYS--PLRIK---HRTGDEITYQCRNGFYPAT-RGNTAKC-TSTGW 314
Query: 355 TPYQGCEALCCPEPKLNNGEITQHRKSRP----ANHCVYFYGDEISFSCHETSRFSAI-C 409
P C C P + +G + RP A Y Y + F S + I C
Sbjct: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
Query: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYIL-VGQAKLS 467
DG WSP P C C FP Y Q+ F + + I C GY L Q ++
Sbjct: 375 TQDG-WSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVT 430
Query: 468 CSYSHWSAPAPQC 480
C + WS P P+C
Sbjct: 431 CMENGWS-PTPRC 442
Score = 121 bits (304), Expect = 2e-27
Identities = 114/456 (25%), Positives = 189/456 (41%), Gaps = 54/456 (11%)
Query: 108 CIYKRCRHPGELRNGQVEIKT--DLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
C+ + C RN ++ + D ++ G+Q + C G+ +G+ C + W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE----W 71
Query: 164 S--HPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
+PL +C+ C P D G + N + YG Y+C+ + LLG + E
Sbjct: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYR---E 128
Query: 221 NETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGF---GPIYNYKDTIVFKCQKGFVLRGS 276
+T G W P CE + C +G++VS Y++ + F C G+ + G
Sbjct: 129 CDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGD 187
Query: 277 SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
+HC D W+ P C SC PD+ + S +++ +Y +Y+C+ GY
Sbjct: 188 EEMHCSDDGFWSKEKPKCVEISC-KSPDVINGS-----PISQKIIYKENERFQYKCNMGY 241
Query: 337 KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHR-KSRPANHCVYFYGDEI 395
+ E +C ++ W P CE C P + NG+ + R K R GDEI
Sbjct: 242 E--YSERGDAVCTES-GWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRT--------GDEI 290
Query: 396 SFSCHE-----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI 450
++ C T +A C G W P C++P G Y ++ +F +
Sbjct: 291 TYQCRNGFYPATRGNTAKCTSTG-WIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAV 349
Query: 451 ----IYECDKGYILVGQA---KLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVE 503
Y CD+ + + + C+ WS PA C C P L NG ++V+
Sbjct: 350 GKYYSYYCDEHFETPSGSYWDHIHCTQDGWS-PAVPCLRKCYFPYLENGYNQNHGRKFVQ 408
Query: 504 PENVTIQCDSGYGVVGPQ-SITCSGNRTWYPEVPKC 538
+++ + C GY + Q ++TC N W P P+C
Sbjct: 409 GKSIDVACHPGYALPKAQTTVTCMEN-GWSP-TPRC 442
Score = 95.1 bits (235), Expect = 2e-19
Identities = 103/392 (26%), Positives = 152/392 (38%), Gaps = 53/392 (13%)
Query: 50 CGPPPTLSFAAPMDITLTETR-FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
CG P F TLT F+ G YTC GY C++DG C
Sbjct: 85 CGHPGDTPFGT---FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC 141
Query: 109 IYKRCRHPGELRNGQV-----EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
+C NG++ E + FG + F C+ G+ + G C D G W
Sbjct: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGF-W 198
Query: 164 SHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
S P+C + CK PD+ NG ++ Y Y C+ + CT
Sbjct: 199 SKEKPKCVEISCK-SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-- 255
Query: 224 IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPI---YNYKDTIVFKCQKGF--VLRGSSV 278
WRP P+CE+ +C P + +G+ + P+ + D I ++C+ GF RG++
Sbjct: 256 ---WRPL-PSCEEKSCDNPYIPNGD----YSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
Query: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHAS--WETYPRPTKEDVYVVGTVLRYRCHPGY 336
C + W P+ P C C + PDI H E RP VG Y C +
Sbjct: 308 -KC-TSTGWIPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFP--VAVGKYYSYYCDEHF 361
Query: 337 K-PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
+ P+ + C ++ W+P C C P L NG H + + G I
Sbjct: 362 ETPSGSYWDHIHCTQD-GWSPAVPCLRKCY-FPYLENGYNQNHGRK-------FVQGKSI 412
Query: 396 SFSCH-----ETSRFSAICQGDGTWSPRTPSC 422
+CH ++ + C +G WSP TP C
Sbjct: 413 DVACHPGYALPKAQTTVTCMENG-WSP-TPRC 442
Score = 31.2 bits (69), Expect = 2.8
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)
Query: 449 EIIYECDKGYILVGQAKLSCSYSHWSA--PAPQC-KALCRKP-ELVNGRLSVDKDQYVE- 503
+ IY+C GY +G + C W A P +C K C P + G ++ E
Sbjct: 47 QAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY 106
Query: 504 PENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
C+ GY ++G + W ++P CE
Sbjct: 107 GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE 142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,950,976
Number of Sequences: 37866
Number of extensions: 1604231
Number of successful extensions: 6217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3252
Number of HSP's gapped (non-prelim): 942
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.