Search of human proteins with 4502199

Search of human proteins with 4502199

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502199 amphiregulin preproprotein [Homo sapiens]
         (252 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502199 amphiregulin preproprotein [Homo sapiens]                  508   e-144
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]                 508   e-144
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]       82   4e-16
gi|29568105 transmembrane protein with EGF-like and two follista...    54   1e-07
gi|12383051 transmembrane protein with EGF-like and two follista...    52   6e-07
gi|4557567 epiregulin preproprotein [Homo sapiens]                     45   5e-05
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                       45   5e-05
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                       44   1e-04
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s...    44   1e-04
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap...    44   1e-04
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                       44   1e-04
gi|4502461 betacellulin [Homo sapiens]                                 43   3e-04
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...    42   4e-04
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                       41   0.001
gi|61806622 epithelial mitogen [Homo sapiens]                          41   0.001
gi|34996489 pleckstrin homology domain interacting protein [Homo...    40   0.003
gi|217330641 IWS1 homolog [Homo sapiens]                               39   0.003
gi|20070380 neuregulin 4 [Homo sapiens]                                39   0.004
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]                38   0.007
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]            38   0.007
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]             38   0.007
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]                    37   0.013
gi|76781482 vascular endothelial growth factor A isoform c precu...    35   0.062
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap...    35   0.062
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap...    35   0.062
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]            35   0.081
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]            35   0.081
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]                35   0.081
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]            35   0.081
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]             35   0.081

>gi|4502199 amphiregulin preproprotein [Homo sapiens]
          Length = 252

 Score =  508 bits (1308), Expect = e-144
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 1   MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG 60
           MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
Sbjct: 1   MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG 60

Query: 61  SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT 120
           SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT
Sbjct: 61  SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT 120

Query: 121 SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER 180
           SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER
Sbjct: 121 SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER 180

Query: 181 CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK 240
           CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK
Sbjct: 181 CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK 240

Query: 241 LRQENGNVHAIA 252
           LRQENGNVHAIA
Sbjct: 241 LRQENGNVHAIA 252


>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
          Length = 252

 Score =  508 bits (1308), Expect = e-144
 Identities = 252/252 (100%), Positives = 252/252 (100%)

Query: 1   MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG 60
           MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
Sbjct: 1   MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG 60

Query: 61  SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT 120
           SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT
Sbjct: 61  SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT 120

Query: 121 SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER 180
           SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER
Sbjct: 121 SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER 180

Query: 181 CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK 240
           CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK
Sbjct: 181 CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK 240

Query: 241 LRQENGNVHAIA 252
           LRQENGNVHAIA
Sbjct: 241 LRQENGNVHAIA 252


>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
          Length = 208

 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 55/150 (36%), Positives = 78/150 (52%), Gaps = 13/150 (8%)

Query: 100 DSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGEC 159
           D +RV    KP    T   N  +  KRKKKG   GK      K++PC  ++++FCIHGEC
Sbjct: 70  DLLRVTLSSKPQALATP--NKEEHGKRKKKGKGLGK------KRDPCLRKYKDFCIHGEC 121

Query: 160 KYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVI 219
           KY++ L A +C C   Y GERC   S+   + + +      LA +A  +S+V L    VI
Sbjct: 122 KYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCL---LVI 178

Query: 220 TVQLRRQYVRK--YEGEAEERKKLRQENGN 247
              L  +Y R+  Y+ E EE+ KL   N +
Sbjct: 179 VGLLMFRYHRRGGYDVENEEKVKLGMTNSH 208


>gi|29568105 transmembrane protein with EGF-like and two
           follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 1/94 (1%)

Query: 145 PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAI 204
           PC      +CIHG+C++I   +  +C+C+  Y G+ C EK+  +   +  S  K+    I
Sbjct: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHC-EKTDFSILYVVPSRQKLTHVLI 332

Query: 205 AAFMSAVILTAVAVITVQLRRQYVRKYEGEAEER 238
           AA + AV +  +  I + + R+  +   G  +++
Sbjct: 333 AAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQ 366


>gi|12383051 transmembrane protein with EGF-like and two
           follistatin-like domains 2 [Homo sapiens]
          Length = 374

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 42/209 (20%), Positives = 86/209 (41%), Gaps = 24/209 (11%)

Query: 41  SGDHSADGFEVTSRSEMSS------GSEISPVSE----------MPSSSEPSSGADYDYS 84
           SGD   +G   TS+ E S+      G+E    +E            ++  P   +D    
Sbjct: 143 SGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASD---G 199

Query: 85  EEYDNEPQIPGYIVDDSVRVE--QVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKK 142
           + YDN  QI         ++E   + +   N T +  + D    +    +N        +
Sbjct: 200 KSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAR 259

Query: 143 KN--PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIA 200
           ++  PC   +  FC+HG+C++  +++  +C+C   Y G+ C +K      ++   + +  
Sbjct: 260 EHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPV-RFQ 318

Query: 201 LAAIAAFMSAVILTAVAVITVQLRRQYVR 229
              IAA +  + +  + V+ + + R+  R
Sbjct: 319 YVLIAAVIGTIQIAVICVVVLCITRKCPR 347


>gi|4557567 epiregulin preproprotein [Homo sapiens]
          Length = 169

 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 16/67 (23%), Positives = 32/67 (47%)

Query: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205
           C+++   +C+HG+C Y+  +    C+C+  Y G RC    +  H  +      + +  I 
Sbjct: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILII 127

Query: 206 AFMSAVI 212
            F+  V+
Sbjct: 128 LFLITVV 134


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 146 CNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAI 204
           CN   +++C++G  C YIE +  ++CKC   Y G+RC + +M   S  +    K  L   
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTIT 404

Query: 205 AAFMSAVILTAVAVI 219
              ++ +++  V V+
Sbjct: 405 GICVALLVVGIVCVV 419


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 1/105 (0%)

Query: 146 CNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAI 204
           CN   +++C++G  C YIE +  ++CKC   +FG+RC EK      M D       L   
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQK 404

Query: 205 AAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVH 249
                  I  A+ V+ +     Y +  +   +    LRQ     H
Sbjct: 405 RVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAH 449


>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
           sapiens]
          Length = 159

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 6/86 (6%)

Query: 144 NPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAA 203
           N C      FC HG C+++   +   C C   Y G RC    +   +++ +S  K A+ A
Sbjct: 44  NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL--AVVAASQKKQAITA 101

Query: 204 IAAF----MSAVILTAVAVITVQLRR 225
           +       ++ +I+T V +   Q+R+
Sbjct: 102 LVVVSIVALAVLIITCVLIHCCQVRK 127


>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
           sapiens]
          Length = 160

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 6/86 (6%)

Query: 144 NPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAA 203
           N C      FC HG C+++   +   C C   Y G RC    +   +++ +S  K A+ A
Sbjct: 45  NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL--AVVAASQKKQAITA 102

Query: 204 IAAF----MSAVILTAVAVITVQLRR 225
           +       ++ +I+T V +   Q+R+
Sbjct: 103 LVVVSIVALAVLIITCVLIHCCQVRK 128


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 17/40 (42%), Positives = 27/40 (67%), Gaps = 1/40 (2%)

Query: 146 CNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEK 184
           CN   +++C++G  C YIE +  ++CKC   +FG+RC EK
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEK 384


>gi|4502461 betacellulin [Homo sapiens]
          Length = 178

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 5/94 (5%)

Query: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205
           C  +++++CI G C+++   +  +C C + Y G RC    +     +     +I +  + 
Sbjct: 69  CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDL---FYLRGDRGQILVICLI 125

Query: 206 AFMSAVILTAVAVITV--QLRRQYVRKYEGEAEE 237
           A M   I+  + V T    LR++  RK + E  E
Sbjct: 126 AVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
            sapiens]
          Length = 1207

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 1/49 (2%)

Query: 140  RKKKNPCNAEFQNFCIH-GECKYIEHLEAVTCKCQQEYFGERCGEKSMK 187
            R   + C      +C+H G C YIE L+   C C   Y GERC  + +K
Sbjct: 970  RNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLK 1018


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 17/46 (36%), Positives = 28/46 (60%), Gaps = 1/46 (2%)

Query: 146 CNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHS 190
           CN   +++C++G  C YIE +  ++CKC   Y G+RC + +M   S
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFS 390


>gi|61806622 epithelial mitogen [Homo sapiens]
          Length = 133

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
           C  +  ++CI+G C +   LE   C+C   Y GERC   ++ +++ +DS    IA+
Sbjct: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYA-VDSYEKYIAI 105


>gi|34996489 pleckstrin homology domain interacting protein [Homo
           sapiens]
          Length = 1821

 Score = 39.7 bits (91), Expect = 0.003
 Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 50  EVTSRSEMSSGSEISPVSEMPSSSEP----SSGADYDYSEEYDNEPQIPGYIVDDSVRVE 105
           E+ + S  S   E+  VS   S  E     S G+  DYS +Y +      +  D  + ++
Sbjct: 811 EIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSD------WTADAGINLQ 864

Query: 106 QVVKPPQNKTE-SENTSDK----PKRKKKGGKNGKNRRNRKKKNP 145
              K P+NKT+ +E++SD+     K+K+K  K  K + N +K  P
Sbjct: 865 PPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGP 909


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 7/102 (6%)

Query: 38  EPFSGDHSADGFEVTSRSEMSSGSE-ISPVSEMPSSSEPSSGADYDYSEEYDNEPQIP-G 95
           E +SGD S DG     + E  SGS+    V+E  S S+  S   +  +E  D E  +P G
Sbjct: 4   EYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKG 63

Query: 96  YIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNR 137
           + V DS   E     P N   S++ S++  R+K      + R
Sbjct: 64  HHVTDSENDE-----PLNLNASDSESEELHRQKDSDSESEER 100


>gi|20070380 neuregulin 4 [Homo sapiens]
          Length = 115

 Score = 38.9 bits (89), Expect = 0.004
 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)

Query: 143 KNPCNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
           + PC    ++FC++G  C  I  + +  C+C + Y G RC E  +   S+   S    A 
Sbjct: 6   EEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAF 65

Query: 202 AAIAAFMSAVI 212
            A+A  ++ +I
Sbjct: 66  VALAVLVTLII 76


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 6/111 (5%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC    M +    +    K  L
Sbjct: 182 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVL 241

Query: 202 AAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
                 ++ +++  + V+     ++  +K       R+ LR E  N+  IA
Sbjct: 242 TITGICIALLVVGIMCVVAYCKTKKQRKKLHDRL--RQSLRSERNNMMNIA 290


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 6/111 (5%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC    M +    +    K  L
Sbjct: 182 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVL 241

Query: 202 AAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
                 ++ +++  + V+     ++  +K       R+ LR E  N+  IA
Sbjct: 242 TITGICIALLVVGIMCVVAYCKTKKQRKKLHDRL--RQSLRSERNNMMNIA 290


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 6/111 (5%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC    M +    +    K  L
Sbjct: 182 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVL 241

Query: 202 AAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
                 ++ +++  + V+     ++  +K       R+ LR E  N+  IA
Sbjct: 242 TITGICIALLVVGIMCVVAYCKTKKQRKKLHDRL--RQSLRSERNNMMNIA 290


>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
          Length = 296

 Score = 37.4 bits (85), Expect = 0.013
 Identities = 30/120 (25%), Positives = 47/120 (39%), Gaps = 11/120 (9%)

Query: 66  VSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPK 125
           VS  PS++       + +S      P  P    +  VR  +    PQ  T   N    PK
Sbjct: 164 VSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQ--TTETNLQTAPK 221

Query: 126 RKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERC 181
                   G +   +     C  + + FC++G EC  ++ L   +   CKC  E+ G+RC
Sbjct: 222 LSTSTSTTGTSHLVK-----CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 276


>gi|76781482 vascular endothelial growth factor A isoform c
           precursor [Homo sapiens]
          Length = 389

 Score = 35.0 bits (79), Expect = 0.062
 Identities = 23/81 (28%), Positives = 35/81 (43%), Gaps = 16/81 (19%)

Query: 113 NKTESENTSDKPKRKKKG--GKNGKNRRNRKKKNPCNAEFQNFCIHGEC----KYIEHLE 166
           NK E     D+ +++KK   GK    +R RKK  PC          G C    K++   +
Sbjct: 306 NKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRPC----------GPCSERRKHLFVQD 355

Query: 167 AVTCKCQQEYFGERCGEKSMK 187
             TCKC  +    RC  + ++
Sbjct: 356 PQTCKCSCKNTDSRCKARQLE 376


>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo
           sapiens]
          Length = 1270

 Score = 35.0 bits (79), Expect = 0.062
 Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 13/109 (11%)

Query: 35  GKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIP 94
           G++E  +    +DG EV + S +    E   +S   S+SEP S + Y + E   N  +  
Sbjct: 285 GEKETQALTPVSDGMEVPNDSALQ---EFFCLSHDESNSEPHSQSSYRHKEMGQNLRETV 341

Query: 95  GY-IVDDSVRV---------EQVVKPPQNKTESENTSDKPKRKKKGGKN 133
            Y ++DD   +          QV+ P    TE+E+T    K K  G +N
Sbjct: 342 SYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQN 390


>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo
           sapiens]
          Length = 1216

 Score = 35.0 bits (79), Expect = 0.062
 Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 13/109 (11%)

Query: 35  GKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIP 94
           G++E  +    +DG EV + S +    E   +S   S+SEP S + Y + E   N  +  
Sbjct: 285 GEKETQALTPVSDGMEVPNDSALQ---EFFCLSHDESNSEPHSQSSYRHKEMGQNLRETV 341

Query: 95  GY-IVDDSVRV---------EQVVKPPQNKTESENTSDKPKRKKKGGKN 133
            Y ++DD   +          QV+ P    TE+E+T    K K  G +N
Sbjct: 342 SYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQN 390


>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score = 34.7 bits (78), Expect = 0.081
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 12/118 (10%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGE-------KSMKTHSMIDS 194
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC         K +    M   
Sbjct: 127 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE 186

Query: 195 SLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
            L +  +  I     A+++  +  +    + +  RK +     R+ LR E  N+  IA
Sbjct: 187 ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRK-KLHDRLRQSLRSERNNMMNIA 243


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score = 34.7 bits (78), Expect = 0.081
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 12/118 (10%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGE-------KSMKTHSMIDS 194
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC         K +    M   
Sbjct: 161 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE 220

Query: 195 SLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
            L +  +  I     A+++  +  +    + +  RK +     R+ LR E  N+  IA
Sbjct: 221 ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRK-KLHDRLRQSLRSERNNMMNIA 277


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score = 34.7 bits (78), Expect = 0.081
 Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 7/113 (6%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGEK-SMKTHSMIDS-SLSKI 199
           C  + + FC++G EC  ++ L   +   CKCQ  + G RC E   MK  +   +  L + 
Sbjct: 28  CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQK 87

Query: 200 ALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
            +  I     A+++  +  +    + +  RK +     R+ LR E  N+  IA
Sbjct: 88  RVLTITGICIALLVVGIMCVVAYCKTKKQRK-KLHDRLRQSLRSERNNMMNIA 139


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score = 34.7 bits (78), Expect = 0.081
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 12/118 (10%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGE-------KSMKTHSMIDS 194
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC         K +    M   
Sbjct: 144 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE 203

Query: 195 SLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
            L +  +  I     A+++  +  +    + +  RK +     R+ LR E  N+  IA
Sbjct: 204 ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRK-KLHDRLRQSLRSERNNMMNIA 260


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score = 34.7 bits (78), Expect = 0.081
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 12/118 (10%)

Query: 146 CNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERCGE-------KSMKTHSMIDS 194
           C  + + FC++G EC  ++ L   +   CKC  E+ G+RC         K +    M   
Sbjct: 182 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE 241

Query: 195 SLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA 252
            L +  +  I     A+++  +  +    + +  RK +     R+ LR E  N+  IA
Sbjct: 242 ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRK-KLHDRLRQSLRSERNNMMNIA 298


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,236,097
Number of Sequences: 37866
Number of extensions: 486688
Number of successful extensions: 2870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 2549
Number of HSP's gapped (non-prelim): 463
length of query: 252
length of database: 18,247,518
effective HSP length: 100
effective length of query: 152
effective length of database: 14,460,918
effective search space: 2198059536
effective search space used: 2198059536
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.