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Search of human proteins with 42794765
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 1261 0.0
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 1245 0.0
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 799 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 238 2e-62
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 238 2e-62
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 204 2e-52
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 198 1e-50
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 197 2e-50
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 172 1e-42
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 168 1e-41
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 167 3e-41
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 158 1e-38
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 158 1e-38
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 155 1e-37
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 155 1e-37
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 155 1e-37
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 155 1e-37
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 155 1e-37
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 154 2e-37
gi|32483399 p21-activated kinase 2 [Homo sapiens] 152 9e-37
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 152 1e-36
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 150 3e-36
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 150 3e-36
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 150 3e-36
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 149 1e-35
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 148 2e-35
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 147 2e-35
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 147 2e-35
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 147 3e-35
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 147 3e-35
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 1261 bits (3263), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF 60
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
Sbjct: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF 60
Query: 61 SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL 120
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
Sbjct: 61 SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL 120
Query: 121 LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG 180
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
Sbjct: 121 LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG 180
Query: 181 YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF 240
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
Sbjct: 181 YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF 240
Query: 241 RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR 300
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
Sbjct: 241 RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR 300
Query: 301 HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI 360
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
Sbjct: 301 HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI 360
Query: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ 420
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ 420
Query: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS 540
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS 540
Query: 541 GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL 600
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
Sbjct: 541 GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL 600
Query: 601 RRIFVEARQRPSAEELLTHHFAQLMY 626
RRIFVEARQRPSAEELLTHHFAQLMY
Sbjct: 601 RRIFVEARQRPSAEELLTHHFAQLMY 626
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 1245 bits (3221), Expect = 0.0
Identities = 626/657 (95%), Positives = 626/657 (95%), Gaps = 31/657 (4%)
Query: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQ------------------ 42
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQ
Sbjct: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTT 60
Query: 43 -------------SDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNE 89
SDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNE
Sbjct: 61 SSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNE 120
Query: 90 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 149
LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
Sbjct: 121 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 180
Query: 150 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 209
DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS
Sbjct: 181 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 240
Query: 210 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKG 269
EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKG
Sbjct: 241 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKG 300
Query: 270 VKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYL 329
VKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYL
Sbjct: 301 VKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYL 360
Query: 330 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELA 389
DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELA
Sbjct: 361 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELA 420
Query: 390 SKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGG 449
SKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGG
Sbjct: 421 SKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGG 480
Query: 450 SVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG 509
SVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG
Sbjct: 481 SVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG 540
Query: 510 ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569
ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE
Sbjct: 541 ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 600
Query: 570 YEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY 626
YEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY
Sbjct: 601 YEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY 657
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 799 bits (2064), Expect = 0.0
Identities = 410/628 (65%), Positives = 482/628 (76%), Gaps = 20/628 (3%)
Query: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF 60
MD+Q+ALNSIM DL L R + ET K K + +Q+DVR+KFEH GE+RI+ F
Sbjct: 1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSS-PKKQNDVRVKFEHRGEKRILQF 59
Query: 61 SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL 120
RPVK ED+ K FGQ +DLHY NNEL I L QDDLDKA+++LDRS MKSL+ILL
Sbjct: 60 PRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILL 119
Query: 121 LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG 180
+ +G ++ ++ S D++ E + R + + RSSPPPG
Sbjct: 120 VI-----------NGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPG 168
Query: 181 YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLS--SAENSLSGSCQSLDRSADSP 238
Y+P+ +AR GS+TSINSEGEFIPE+ +Q MLDPLS S ENS SGSC SLD D
Sbjct: 169 YIPDELHQVARNGSFTSINSEGEFIPESMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE 227
Query: 239 SFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRI 298
S+ KSRM RAQS+PDN QE+SD + +++K KGGTYPRRYHVS HH++Y+DGR+TFPR
Sbjct: 228 SYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRA 287
Query: 299 RRHQGNLF----TLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSEN-ALSVQERNVPT 353
RR QG + P+ SLST+ + +Y D R R R +D +N L+V + + P+
Sbjct: 288 RRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPS 347
Query: 354 KSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEI 413
+SP AP NWR GKLLGQGAFGRVYLCYDVDTGRELA KQVQFDPDSPETSKEV+ALECEI
Sbjct: 348 RSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEI 407
Query: 414 QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQI 473
QLLKNL HERIVQYYGCLRD EKTL+IFMEYMPGGS+KDQLKAYGALTE+VTRKYTRQI
Sbjct: 408 QLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQI 467
Query: 474 LEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYW 533
LEG+ YLHSNMIVHRDIKGANILRDS GNVKLGDFGASKRLQTIC+SGTGM+SVTGTPYW
Sbjct: 468 LEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYW 527
Query: 534 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHIS 593
MSPEVISGEGYGRKAD+WS+ CTVVEMLTEKPPWAE+EAMAAIFKIATQPTNP+LP H+S
Sbjct: 528 MSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVS 587
Query: 594 EHGRDFLRRIFVEARQRPSAEELLTHHF 621
++ RDFL+RIFVEA+ RPSA+ELL H F
Sbjct: 588 DYTRDFLKRIFVEAKLRPSADELLRHMF 615
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 238 bits (606), Expect = 2e-62
Identities = 134/291 (46%), Positives = 184/291 (63%), Gaps = 21/291 (7%)
Query: 340 SENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS 399
SEN+L +E PI W +G++LG+GA+G VY C G+ +A KQV D +
Sbjct: 1049 SENSLKSEE----------PILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSN 1097
Query: 400 P-ETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKA 457
KE L+ E+ LLK L+H IV Y G CL+ E T++IFME++PGGS+ +
Sbjct: 1098 KLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINR 1154
Query: 458 YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTI 517
+G L E V KYT+QIL+G++YLH N +VHRDIKG N++ G +KL DFG ++RL
Sbjct: 1155 FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWA 1214
Query: 518 CMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574
++GT ++S+ GTPYWM+PEVI+ GYGRK+D+WS+GCTV EM T KPP A + MA
Sbjct: 1215 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1274
Query: 575 AIFKI-ATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 623
A+F I A + P LP H SE+ DF+R + +RPSA +LL H F +
Sbjct: 1275 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 1325
Score = 32.7 bits (73), Expect = 1.0
Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 17/153 (11%)
Query: 224 LSGSCQSLDRSA-----DSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRR 278
L SC L+ S D+P F K + +++ F + +YS R + + P R
Sbjct: 161 LPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPL--SLLPTR 218
Query: 279 YHVSV---HHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYL-DPRGR 334
V +HK + R P + L V S LS + E G V+ L DP
Sbjct: 219 SGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDP--T 276
Query: 335 LRSAD----SENALSVQERNVPTKSPSAPINWR 363
LRS+D S N S + N + NW+
Sbjct: 277 LRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWK 309
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 238 bits (606), Expect = 2e-62
Identities = 134/291 (46%), Positives = 184/291 (63%), Gaps = 21/291 (7%)
Query: 340 SENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS 399
SEN+L +E PI W +G++LG+GA+G VY C G+ +A KQV D +
Sbjct: 231 SENSLKSEE----------PILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSN 279
Query: 400 P-ETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKA 457
KE L+ E+ LLK L+H IV Y G CL+ E T++IFME++PGGS+ +
Sbjct: 280 KLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINR 336
Query: 458 YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTI 517
+G L E V KYT+QIL+G++YLH N +VHRDIKG N++ G +KL DFG ++RL
Sbjct: 337 FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWA 396
Query: 518 CMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574
++GT ++S+ GTPYWM+PEVI+ GYGRK+D+WS+GCTV EM T KPP A + MA
Sbjct: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456
Query: 575 AIFKI-ATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 623
A+F I A + P LP H SE+ DF+R + +RPSA +LL H F +
Sbjct: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 204 bits (520), Expect = 2e-52
Identities = 118/268 (44%), Positives = 164/268 (61%), Gaps = 15/268 (5%)
Query: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPD-SPETSKEVSALECEIQLLKNLQ 420
W +G+ +G GAF Y DV TG +A KQV + + S E + V AL EI+++ +L
Sbjct: 1243 WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLN 1302
Query: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
H I++ G +++ L F+E+M GGSV L YGA ESV YT Q+L G+SYL
Sbjct: 1303 HPNIIRMLGATCEKSNYNL--FIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYL 1360
Query: 481 HSNMIVHRDIKGANILRDSAG-NVKLGDFGASKRLQTICMSGTG----MRSVTGTPYWMS 535
H N I+HRD+KGAN+L DS G +++ DFGA+ RL + GTG + GT +M+
Sbjct: 1361 HENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGTIAFMA 1417
Query: 536 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPW-AEYEA--MAAIFKIATQPTNPQLPSHI 592
PEV+ G+ YGR DVWS+GC ++EM KPPW AE + +A IFKIA+ T P +PSH+
Sbjct: 1418 PEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHL 1477
Query: 593 SEHGRDF-LRRIFVEARQRPSAEELLTH 619
S RD LR + ++ + RP + ELL H
Sbjct: 1478 SPGLRDVALRCLELQPQDRPPSRELLKH 1505
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 198 bits (504), Expect = 1e-50
Identities = 149/510 (29%), Positives = 236/510 (46%), Gaps = 32/510 (6%)
Query: 120 LLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPP 179
L+++ H PHS V+ S + +P + HL + + + P
Sbjct: 1121 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP 1180
Query: 180 GYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPS 239
A + + + P + + +SSA ++ S DR A +
Sbjct: 1181 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA 1240
Query: 240 FRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIR 299
+ R S P +R+ Y +G G+ R + + D I
Sbjct: 1241 ELQFRSLSRHSSPTE-----ERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE 1295
Query: 300 RHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAP 359
Q ++ L R +N + Q D +N + V R V K
Sbjct: 1296 AIQKSV-RLFEEKRYREMRRKN--IIGQVCDT-----PKSYDNVMHVGLRKVTFK----- 1342
Query: 360 INWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL 419
W+RG +G+G +G+VY C VDTG +A K+++F P+ +T KE + E+++ + +
Sbjct: 1343 --WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGI 1397
Query: 420 QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSY 479
+H +V+Y+G R E + IFMEY G++++ + L E V R Y++QI ++
Sbjct: 1398 KHPNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINV 1453
Query: 480 LHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEV 538
LH + IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEV
Sbjct: 1454 LHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEV 1513
Query: 539 IS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEH 595
I+ GEG+GR AD+WSLGC V+EM+T K PW EYE I P +P +S
Sbjct: 1514 ITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPE 1573
Query: 596 GRDFLRR-IFVEARQRPSAEELLTHHFAQL 624
G+DFL + + + R +A +LL H F ++
Sbjct: 1574 GKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 197 bits (502), Expect = 2e-50
Identities = 113/289 (39%), Positives = 170/289 (58%), Gaps = 19/289 (6%)
Query: 341 ENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSP 400
+N + V R V K W+RG +G+G +G+VY C VDTG +A K+++F P+
Sbjct: 1279 DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH 1331
Query: 401 ETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA 460
+T KE + E+++ + ++H +V+Y+G R E + IFMEY G++++ +
Sbjct: 1332 KTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--G 1384
Query: 461 LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMS 520
L E V R Y++QI ++ LH + IVHRDIKGANI S+G +KLGDFG S +L+ +
Sbjct: 1385 LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQT 1444
Query: 521 GTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAI 576
G + S GT +M+PEVI+ GEG+GR AD+WSLGC V+EM+T K PW EYE I
Sbjct: 1445 MPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQI 1504
Query: 577 FKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFAQL 624
P +P +S G+DFL + + + R +A +LL H F ++
Sbjct: 1505 MYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1553
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 172 bits (435), Expect = 1e-42
Identities = 107/262 (40%), Positives = 151/262 (57%), Gaps = 18/262 (6%)
Query: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
+LG+G +G VY D+ +A K++ PE S L EI L K L+H IV
Sbjct: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKYLKHRNIV 185
Query: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGALTESVTRKYTRQILEGMSYLHSNM 484
QY G + + + IFME +PGGS+ L++ +G + E + YT+QILEG+ YLH N
Sbjct: 186 QYLGSVSENGY--IKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQ 243
Query: 485 IVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SG 541
IVHRDIKG N+L ++ +G VK+ DFG SKRL + + TGT +M+PE+I
Sbjct: 244 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGV---NPCTETFTGTLQYMAPEIIDQGP 300
Query: 542 EGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRDFL 600
GYG AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S R F+
Sbjct: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
Query: 601 RRIF-VEARQRPSAEELLTHHF 621
F + +R + ELL F
Sbjct: 361 LSCFEPDPHKRATTAELLREGF 382
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 168 bits (426), Expect = 1e-41
Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 20/267 (7%)
Query: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
+LG+G +G VY D+ +A K++ PE S L EI L K+L+H+ IV
Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKHLKHKNIV 738
Query: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 482
QY G + + IFME +PGGS+ L++ +G L E YT+QILEG+ YLH
Sbjct: 739 QYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 796
Query: 483 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 539
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 797 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---NPCTETFTGTLQYMAPEIIDK 853
Query: 540 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 598
GYG+ AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S +
Sbjct: 854 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
Query: 599 FLRRIF-VEARQRPSAEELLTHHFAQL 624
F+ + F + +R A +LL F ++
Sbjct: 914 FILKCFEPDPDKRACANDLLVDEFLKV 940
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 167 bits (423), Expect = 3e-41
Identities = 112/266 (42%), Positives = 153/266 (57%), Gaps = 20/266 (7%)
Query: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
+LG+G +G VY D T +A K++ PE S L EI L + L+H+ IV
Sbjct: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEI------PERDSRFSQPLHEEIALHRRLRHKNIV 706
Query: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 482
+Y G L IFME +PGGS+ L++ +G L ES YTRQIL+G+ YLH
Sbjct: 707 RYLGSASQGGY--LKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHD 764
Query: 483 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 539
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 765 NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ 821
Query: 540 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 598
GYG+ AD+WSLGCTV+EM T +PP+ E AA+F++ +P +PS +S +
Sbjct: 822 GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA 881
Query: 599 FLRRIF-VEARQRPSAEELLTHHFAQ 623
FL R F + R R SA+ LL F Q
Sbjct: 882 FLLRTFEPDPRLRASAQTLLGDPFLQ 907
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 158 bits (400), Expect = 1e-38
Identities = 142/504 (28%), Positives = 233/504 (46%), Gaps = 61/504 (12%)
Query: 137 SRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYT 196
SR V + +SQS G + +Y S PG+ P +PE+ + + + T
Sbjct: 99 SRPVTVASSQSEGKMPDLYG-----------SQMCPGKL---PEGIPEQWARLLQTSNIT 144
Query: 197 SINSEGEFIPETSEQCMLDPLS------SAENSLSGSCQSLDRSADS-----PSFRKSRM 245
+ + + Q +LD L + N S S D+SA PS K+
Sbjct: 145 KLEQK------KNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTAS 198
Query: 246 SRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHV-SVHHKDYSDGRRTFPRIRRHQGN 304
+ P + +E + E + + PR H S++ + + +
Sbjct: 199 EPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS---------- 248
Query: 305 LFTLVPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWR 363
VP+ + EN + Y + R R +S ++ + + R++ + +
Sbjct: 249 --PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYT 305
Query: 364 RGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHER 423
R + +GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++
Sbjct: 306 RFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPN 360
Query: 424 IVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN 483
IV Y E L + MEY+ GGS+ D + + E R+ L+ + +LHSN
Sbjct: 361 IVNYLDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSN 417
Query: 484 MIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEG 543
++HRDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ +
Sbjct: 418 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKA 474
Query: 544 YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLR 601
YG K D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL
Sbjct: 475 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLN 533
Query: 602 R-IFVEARQRPSAEELLTHHFAQL 624
R + ++ +R SA+ELL H F +L
Sbjct: 534 RCLEMDVDRRGSAKELLQHPFLKL 557
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 158 bits (400), Expect = 1e-38
Identities = 101/263 (38%), Positives = 144/263 (54%), Gaps = 23/263 (8%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
LG+G++G VY +TG+ +A KQV + D E KE+S +++ +V+Y
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEIS-------IMQQCDSPHVVKY 88
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYG-ALTESVTRKYTRQILEGMSYLHSNMIV 486
YG + L I MEY GSV D ++ LTE + L+G+ YLH +
Sbjct: 89 YGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKI 146
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRL-QTICMSGTGMRSVTGTPYWMSPEVISGEGYG 545
HRDIK NIL ++ G+ KL DFG + +L T+ T V GTP+WM+PEVI GY
Sbjct: 147 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT----VIGTPFWMAPEVIQEIGYN 202
Query: 546 RKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP----QLPSHISEHGRDFLR 601
AD+WSLG T +EM KPP+A+ M AIF I PTNP + P S++ DF++
Sbjct: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMI---PTNPPPTFRKPELWSDNFTDFVK 259
Query: 602 RIFVEA-RQRPSAEELLTHHFAQ 623
+ V++ QR +A +LL H F +
Sbjct: 260 QCLVKSPEQRATATQLLQHPFVR 282
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 155 bits (391), Expect = 1e-37
Identities = 107/320 (33%), Positives = 170/320 (53%), Gaps = 17/320 (5%)
Query: 309 VPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWRRGKL 367
VP+ + EN + Y + R R +S ++ + + R++ + + R +
Sbjct: 230 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYTRFEK 288
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++ IV Y
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPNIVNY 343
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 344 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 400
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ + YG K
Sbjct: 401 RDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 457
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRR-IF 604
D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 458 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 516
Query: 605 VEARQRPSAEELLTHHFAQL 624
++ +R SA+ELL H F +L
Sbjct: 517 MDVDRRGSAKELLQHPFLKL 536
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 155 bits (391), Expect = 1e-37
Identities = 107/320 (33%), Positives = 170/320 (53%), Gaps = 17/320 (5%)
Query: 309 VPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWRRGKL 367
VP+ + EN + Y + R R +S ++ + + R++ + + R +
Sbjct: 236 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYTRFEK 294
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++ IV Y
Sbjct: 295 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPNIVNY 349
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 350 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 406
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ + YG K
Sbjct: 407 RDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 463
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRR-IF 604
D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 464 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 522
Query: 605 VEARQRPSAEELLTHHFAQL 624
++ +R SA+ELL H F +L
Sbjct: 523 MDVDRRGSAKELLQHPFLKL 542
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 1e-37
Identities = 107/320 (33%), Positives = 170/320 (53%), Gaps = 17/320 (5%)
Query: 309 VPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWRRGKL 367
VP+ + EN + Y + R R +S ++ + + R++ + + R +
Sbjct: 215 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYTRFEK 273
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++ IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPNIVNY 328
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRR-IF 604
D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 605 VEARQRPSAEELLTHHFAQL 624
++ +R SA+ELL H F +L
Sbjct: 502 MDVDRRGSAKELLQHPFLKL 521
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 1e-37
Identities = 107/320 (33%), Positives = 170/320 (53%), Gaps = 17/320 (5%)
Query: 309 VPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWRRGKL 367
VP+ + EN + Y + R R +S ++ + + R++ + + R +
Sbjct: 215 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYTRFEK 273
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++ IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPNIVNY 328
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRR-IF 604
D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 605 VEARQRPSAEELLTHHFAQL 624
++ +R SA+ELL H F +L
Sbjct: 502 MDVDRRGSAKELLQHPFLKL 521
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 1e-37
Identities = 107/320 (33%), Positives = 170/320 (53%), Gaps = 17/320 (5%)
Query: 309 VPSSRSLSTNGENMGLAVQYLDP-RGRLRSADSENALSVQERNVPTKSPSAPINWRRGKL 367
VP+ + EN + Y + R R +S ++ + + R++ + + R +
Sbjct: 215 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKK-KYTRFEK 273
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+GQGA G VY D+ TG+E+A KQ+ + KE+ + EI +++ ++ IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKNPNIVNY 328
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRR-IF 604
D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 605 VEARQRPSAEELLTHHFAQL 624
++ +R SA+ELL H F +L
Sbjct: 502 MDVDRRGSAKELLQHPFLKL 521
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 154 bits (390), Expect = 2e-37
Identities = 98/266 (36%), Positives = 149/266 (56%), Gaps = 15/266 (5%)
Query: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQH 421
+ R + +GQGA G VY DV TG+E+A KQ+ + KE+ + EI +++ ++
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKN 324
Query: 422 ERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH 481
IV Y E L + MEY+ GGS+ D + + E R+ L+ + +LH
Sbjct: 325 PNIVNYLDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLH 381
Query: 482 SNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISG 541
SN ++HRDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++
Sbjct: 382 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTR 438
Query: 542 EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDF 599
+ YG K D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDF
Sbjct: 439 KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSAIFRDF 497
Query: 600 LRR-IFVEARQRPSAEELLTHHFAQL 624
L R + ++ +R SA+ELL H F ++
Sbjct: 498 LNRCLEMDVEKRGSAKELLQHQFLKI 523
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 152 bits (384), Expect = 9e-37
Identities = 96/266 (36%), Positives = 150/266 (56%), Gaps = 15/266 (5%)
Query: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQH 421
+ R + +GQGA G V+ DV G+E+A KQ+ + KE+ + EI ++K L++
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK---QPKKEL--IINEILVMKELKN 303
Query: 422 ERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH 481
IV + E L + MEY+ GGS+ D + + E+ R+ L+ + +LH
Sbjct: 304 PNIVNFLDSYLVGDE--LFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLH 360
Query: 482 SNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISG 541
+N ++HRDIK N+L G+VKL DFG + I + ++ GTPYWM+PEV++
Sbjct: 361 ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTR 417
Query: 542 EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDF 599
+ YG K D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDF
Sbjct: 418 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSPIFRDF 476
Query: 600 LRR-IFVEARQRPSAEELLTHHFAQL 624
L R + ++ +R SA+ELL H F +L
Sbjct: 477 LNRCLEMDVEKRGSAKELLQHPFLKL 502
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 152 bits (383), Expect = 1e-36
Identities = 99/260 (38%), Positives = 138/260 (53%), Gaps = 22/260 (8%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G+G+FG VY D T +A K + D E E+ ++ EI +L I +Y
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYITRY 81
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
+G + L I MEY+ GGS D LK G L E+ R+IL+G+ YLHS +H
Sbjct: 82 FGSYLKSTK--LWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIH 138
Query: 488 RDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
RDIK AN+L G+VKL DFG + +L + + GTP+WM+PEVI Y K
Sbjct: 139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDFK 195
Query: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEA 607
AD+WSLG T +E+ +PP ++ M +F I P N P+ +H + F + FVEA
Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLI---PKNSP-PTLEGQHSKPF--KEFVEA 249
Query: 608 ------RQRPSAEELLTHHF 621
R RP+A+ELL H F
Sbjct: 250 CLNKDPRFRPTAKELLKHKF 269
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 150 bits (380), Expect = 3e-36
Identities = 98/261 (37%), Positives = 140/261 (53%), Gaps = 23/261 (8%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
LG+G++G V+ ++G+ +A KQV + D E KE+S +++ +V+Y
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEIS-------IMQQCDSPYVVKY 85
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYG-ALTESVTRKYTRQILEGMSYLHSNMIV 486
YG + L I MEY GSV D ++ L E + L+G+ YLH +
Sbjct: 86 YGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 143
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRL-QTICMSGTGMRSVTGTPYWMSPEVISGEGYG 545
HRDIK NIL ++ G+ KL DFG + +L T+ T V GTP+WM+PEVI GY
Sbjct: 144 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT----VIGTPFWMAPEVIQEIGYN 199
Query: 546 RKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP----QLPSHISEHGRDFLR 601
AD+WSLG T +EM KPP+A+ M AIF I PTNP + P S+ DF++
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI---PTNPPPTFRKPELWSDDFTDFVK 256
Query: 602 RIFVE-ARQRPSAEELLTHHF 621
+ V+ QR +A +LL H F
Sbjct: 257 KCLVKNPEQRATATQLLQHPF 277
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 150 bits (379), Expect = 3e-36
Identities = 97/258 (37%), Positives = 139/258 (53%), Gaps = 18/258 (6%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G+G+FG V+ D T + +A K + D E E+ ++ EI +L + +Y
Sbjct: 30 IGKGSFGEVFKGIDNRTQKVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYVTKY 85
Query: 428 YGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIV 486
YG L+D L I MEY+ GGS D L+ G L E+ R+IL+G+ YLHS +
Sbjct: 86 YGSYLKDTK---LWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKI 141
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
HRDIK AN+L G VKL DFG + +L + + GTP+WM+PEVI Y
Sbjct: 142 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDS 198
Query: 547 KADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTN--PQLPSHISEHGRDFLRR-I 603
KAD+WSLG T +E+ +PP +E M +F I P N P L + S+ ++F+ +
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLI---PKNNPPTLEGNYSKPLKEFVEACL 255
Query: 604 FVEARQRPSAEELLTHHF 621
E RP+A+ELL H F
Sbjct: 256 NKEPSFRPTAKELLKHKF 273
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 150 bits (379), Expect = 3e-36
Identities = 97/258 (37%), Positives = 139/258 (53%), Gaps = 18/258 (6%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G+G+FG V+ D T + +A K + D E E+ ++ EI +L + +Y
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYVTKY 97
Query: 428 YGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIV 486
YG L+D L I MEY+ GGS D L+ G L E+ R+IL+G+ YLHS +
Sbjct: 98 YGSYLKDTK---LWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKI 153
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR 546
HRDIK AN+L G VKL DFG + +L + + GTP+WM+PEVI Y
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDS 210
Query: 547 KADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTN--PQLPSHISEHGRDFLRR-I 603
KAD+WSLG T +E+ +PP +E M +F I P N P L + S+ ++F+ +
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLI---PKNNPPTLEGNYSKPLKEFVEACL 267
Query: 604 FVEARQRPSAEELLTHHF 621
E RP+A+ELL H F
Sbjct: 268 NKEPSFRPTAKELLKHKF 285
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 149 bits (375), Expect = 1e-35
Identities = 96/259 (37%), Positives = 145/259 (55%), Gaps = 15/259 (5%)
Query: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQH 421
+ R + +GQGA G VY DV TG+E+A KQ+ + KE+ + EI +++ ++
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ---QPKKEL--IINEILVMRENKN 324
Query: 422 ERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH 481
IV Y E L + MEY+ GGS+ D + + E R+ L+ + +LH
Sbjct: 325 PNIVNYLDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLH 381
Query: 482 SNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISG 541
SN ++HRDIK NIL G+VKL DFG + I + ++ GTPYWM+PEV++
Sbjct: 382 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTMVGTPYWMAPEVVTR 438
Query: 542 EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDF 599
+ YG K D+WSLG +EM+ +PP+ + A++ IAT T P+L P +S RDF
Sbjct: 439 KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSAIFRDF 497
Query: 600 LRR-IFVEARQRPSAEELL 617
L R + ++ +R SA+ELL
Sbjct: 498 LNRCLEMDVEKRGSAKELL 516
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 148 bits (373), Expect = 2e-35
Identities = 99/263 (37%), Positives = 141/263 (53%), Gaps = 20/263 (7%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
LG GAFG+VY + +TG A+K ++ ++ +E+ EI++L H IV+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIE-----TKSEEELEDYIVEIEILATCDHPYIVKL 96
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKD-QLKAYGALTESVTRKYTRQILEGMSYLHSNMIV 486
G + L I +E+ PGG+V L+ LTE + RQ+LE +++LHS I+
Sbjct: 97 LGAYYHDGK--LWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRII 154
Query: 487 HRDIKGANILRDSAGNVKLGDFGAS-KRLQTICMSGTGMRSVTGTPYWMSPEVISGE--- 542
HRD+K N+L G+++L DFG S K L+T+ S GTPYWM+PEV+ E
Sbjct: 155 HRDLKAGNVLMTLEGDIRLADFGVSAKNLKTL----QKRDSFIGTPYWMAPEVVMCETMK 210
Query: 543 --GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA-TQPTNPQLPSHISEHGRDF 599
Y KAD+WSLG T++EM +PP E M + KIA + P PS S RDF
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDF 270
Query: 600 LR-RIFVEARQRPSAEELLTHHF 621
L+ + RPSA +LL H F
Sbjct: 271 LKIALDKNPETRPSAAQLLEHPF 293
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 147 bits (372), Expect = 2e-35
Identities = 99/260 (38%), Positives = 142/260 (54%), Gaps = 19/260 (7%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G G+FG VY DV +A K++ + +++++ + E++ L+ L+H +QY
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYS--GKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA-LTESVTRKYTRQILEGMSYLHSNMIV 486
GC E T + MEY G S D L+ + L E T L+G++YLHS+ ++
Sbjct: 92 RGCYL--REHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 148
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SGEG- 543
HRD+K NIL G VKLGDFG++ + S GTPYWM+PEVI EG
Sbjct: 149 HRDVKAGNILLSEPGLVKLGDFGSASIM-------APANSFVGTPYWMAPEVILAMDEGQ 201
Query: 544 YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS-HISEHGRDFLRR 602
Y K DVWSLG T +E+ KPP AM+A++ IA Q +P L S H SE+ R+F+
Sbjct: 202 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIA-QNESPVLQSGHWSEYFRNFVDS 260
Query: 603 IFVEARQ-RPSAEELLTHHF 621
+ Q RP++E LL H F
Sbjct: 261 CLQKIPQDRPTSEVLLKHRF 280
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 147 bits (372), Expect = 2e-35
Identities = 99/260 (38%), Positives = 142/260 (54%), Gaps = 19/260 (7%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G G+FG VY DV +A K++ + +++++ + E++ L+ L+H +QY
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYS--GKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA-LTESVTRKYTRQILEGMSYLHSNMIV 486
GC E T + MEY G S D L+ + L E T L+G++YLHS+ ++
Sbjct: 92 RGCYL--REHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 148
Query: 487 HRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SGEG- 543
HRD+K NIL G VKLGDFG++ + S GTPYWM+PEVI EG
Sbjct: 149 HRDVKAGNILLSEPGLVKLGDFGSASIM-------APANSFVGTPYWMAPEVILAMDEGQ 201
Query: 544 YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS-HISEHGRDFLRR 602
Y K DVWSLG T +E+ KPP AM+A++ IA Q +P L S H SE+ R+F+
Sbjct: 202 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIA-QNESPVLQSGHWSEYFRNFVDS 260
Query: 603 IFVEARQ-RPSAEELLTHHF 621
+ Q RP++E LL H F
Sbjct: 261 CLQKIPQDRPTSEVLLKHRF 280
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 147 bits (371), Expect = 3e-35
Identities = 97/262 (37%), Positives = 143/262 (54%), Gaps = 19/262 (7%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G G +G VY +V TG A K ++ +P + S ++ EI ++K +H IV Y
Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-----DFSLIQQEIFMVKECKHCNIVAY 80
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
+G R + L I MEY GGS++D G L+E R+ L+G++YLH+ +H
Sbjct: 81 FGSYLSREK--LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMH 138
Query: 488 RDIKGANILRDSAGNVKLGDFG-ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE---G 543
RDIKGANIL G+VKL DFG A+K TI +S GTPYWM+PEV + E G
Sbjct: 139 RDIKGANILLTDHGDVKLADFGVAAKITATIAK----RKSFIGTPYWMAPEVAAVEKNGG 194
Query: 544 YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIF---KIATQPTNPQLPSHISEHGRDFL 600
Y + D+W++G T +E+ +PP + M A+F K QP + + S +F+
Sbjct: 195 YNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFV 254
Query: 601 R-RIFVEARQRPSAEELLTHHF 621
+ + ++RP+AE LLTH F
Sbjct: 255 KIALTKNPKKRPTAERLLTHTF 276
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 147 bits (371), Expect = 3e-35
Identities = 97/262 (37%), Positives = 143/262 (54%), Gaps = 19/262 (7%)
Query: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
+G G +G VY +V TG A K ++ +P + S ++ EI ++K +H IV Y
Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-----DFSLIQQEIFMVKECKHCNIVAY 80
Query: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 487
+G R + L I MEY GGS++D G L+E R+ L+G++YLH+ +H
Sbjct: 81 FGSYLSREK--LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMH 138
Query: 488 RDIKGANILRDSAGNVKLGDFG-ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE---G 543
RDIKGANIL G+VKL DFG A+K TI +S GTPYWM+PEV + E G
Sbjct: 139 RDIKGANILLTDHGDVKLADFGVAAKITATIAK----RKSFIGTPYWMAPEVAAVEKNGG 194
Query: 544 YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIF---KIATQPTNPQLPSHISEHGRDFL 600
Y + D+W++G T +E+ +PP + M A+F K QP + + S +F+
Sbjct: 195 YNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFV 254
Query: 601 R-RIFVEARQRPSAEELLTHHF 621
+ + ++RP+AE LLTH F
Sbjct: 255 KIALTKNPKKRPTAERLLTHTF 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,891,128
Number of Sequences: 37866
Number of extensions: 1170010
Number of successful extensions: 6334
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 738
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 3789
Number of HSP's gapped (non-prelim): 1099
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.