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Search of human proteins with 126362971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126362971 serine/threonine kinase 10 [Homo sapiens]
(968 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 1914 0.0
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 607 e-173
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 266 7e-71
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 265 2e-70
gi|148746218 TAO kinase 3 [Homo sapiens] 251 3e-66
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 249 7e-66
gi|45439370 TAO kinase 1 [Homo sapiens] 246 7e-65
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 246 1e-64
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 245 2e-64
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 245 2e-64
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 244 3e-64
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 243 8e-64
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 241 2e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 241 2e-63
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 240 5e-63
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 240 5e-63
gi|145275208 myosin IIIA [Homo sapiens] 238 2e-62
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 236 8e-62
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 236 8e-62
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 234 3e-61
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 229 1e-59
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 227 5e-59
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 227 5e-59
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 227 5e-59
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 227 5e-59
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 227 5e-59
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 227 5e-59
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 227 5e-59
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 227 5e-59
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 226 6e-59
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 1914 bits (4957), Expect = 0.0
Identities = 968/968 (100%), Positives = 968/968 (100%)
Query: 1 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA 60
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA
Sbjct: 1 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA 60
Query: 61 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA 120
LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA
Sbjct: 61 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA 120
Query: 121 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA 180
IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
Sbjct: 121 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA 180
Query: 181 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL 240
KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL
Sbjct: 181 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL 240
Query: 241 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN 300
NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN
Sbjct: 241 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN 300
Query: 301 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE 360
KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE
Sbjct: 301 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE 360
Query: 361 SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDA 420
SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDA
Sbjct: 361 SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDA 420
Query: 421 RIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGP 480
RIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGP
Sbjct: 421 RIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGP 480
Query: 481 SKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV 540
SKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV
Sbjct: 481 SKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV 540
Query: 541 SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ
Sbjct: 541 SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
Query: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM 660
EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM
Sbjct: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM 660
Query: 661 KKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRRE 720
KKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRRE
Sbjct: 661 KKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRRE 720
Query: 721 ICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKE 780
ICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKE
Sbjct: 721 ICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKE 780
Query: 781 REQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKI 840
REQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKI
Sbjct: 781 REQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKI 840
Query: 841 KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK 900
KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK
Sbjct: 841 KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK 900
Query: 901 ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFF 960
ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFF
Sbjct: 901 ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFF 960
Query: 961 PYSSADAS 968
PYSSADAS
Sbjct: 961 PYSSADAS 968
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 607 bits (1566), Expect = e-173
Identities = 320/650 (49%), Positives = 444/650 (68%), Gaps = 28/650 (4%)
Query: 315 MEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDS 374
M EIE+G+++ E A++++ + + + P + + ES ST S
Sbjct: 608 MNEIEEGKNK---EQAINSSENIMDINEE------PGTTEGEEITESSSTE---EMEVRS 655
Query: 375 VNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQG 434
V Q + +Q S E +K PVS+ +V Q E
Sbjct: 656 VVADTDQKALGSEVQDASKVTTQIDKE---------KKEIPVSIKKEPEVTVVSQPTEPQ 706
Query: 435 GDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
L P+ N + + +++ +L ++ PP P + DS S +
Sbjct: 707 PVLIPSININSDSGENKEEIGSLSK-------TETILPPESENPKENDNDSGTGSTADTS 759
Query: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
S+D ++S+ LS K+ GS+S+++ + KKTLK+TRKF+VDGVEVS+TTSKI+++ + K
Sbjct: 760 SIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSK 819
Query: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
EE+RFLRRQELRELR LQKEE R Q QL++K + Q EQ+ +RFEQE+ +KK+ +D E+E
Sbjct: 820 TEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIE 879
Query: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQ 674
NLE+QQKQ +E++EQ+H R R+EA+RI+ EQ+++ ++FQ LK KKEV NEVEK P++
Sbjct: 880 NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKE 939
Query: 675 QRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQE 734
RKE MK++ EE Q + +++FV KQ+++L+ ++K++ + E+ + ERECL KQ+
Sbjct: 940 LRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQ 999
Query: 735 LLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQ 794
L+R REAA+WE+EE LQE+HQL+KQQLKDQYF+QRH+LL++HEKE EQMQRYNQR+IE+
Sbjct: 1000 LMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEE 1059
Query: 795 LKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSE 854
LK RQ QE+ARLPKIQRSE KTRMAM+KKSL IN + + R+KIKQF+ QEEKRQK+E
Sbjct: 1060 LKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNE 1119
Query: 855 RLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWR 914
R+ Q QKHENQMRD+ QCE+N+ EL QLQNEKCHLLVEHETQKLK LDE H+Q LKEWR
Sbjct: 1120 RMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWR 1179
Query: 915 DKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSS 964
+KLRPRKK LEE+ +K +EQE+FFK++ E+EC NPST S+ +KF+P S
Sbjct: 1180 EKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPS 1229
Score = 510 bits (1313), Expect = e-144
Identities = 253/381 (66%), Positives = 312/381 (81%), Gaps = 9/381 (2%)
Query: 1 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA 60
M+F NFR+I +L + +K+K +YEHV+RDL+P + WEI+GELGDGAFGKVYKA+NKET
Sbjct: 1 MSFFNFRKIFKLGSEKKKK--QYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSV 58
Query: 61 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA 120
LAAAKVI+TKSEEELEDY+VEI+ILA+CDHP IVKLL A+Y++ LWI+IEFC GGAVDA
Sbjct: 59 LAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDA 118
Query: 121 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA 180
+MLEL+R LTE QIQVVC+Q L+ALN+LH +IIHRDLKAGN+L TL+GDI+LADFGVSA
Sbjct: 119 VMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA 178
Query: 181 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL 240
KN +T+Q+RDSFIGTPYWMAPEVVMCET KD PYDYKAD+WSLGITLIEMA+IEPPHHEL
Sbjct: 179 KNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL 238
Query: 241 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN 300
NPMRVLLKIAKS+PPTL PS+WS F+DFLK L+KN + R + +QLL+HPFV ++ SN
Sbjct: 239 NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDSN 297
Query: 301 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLE- 359
K +REL+AEAKAEV EE+EDG++E EEE+ + + + + SS++S S DK +
Sbjct: 298 KPIRELIAEAKAEVTEEVEDGKEEDEEEE-TENSLPIPASKRASSDLSIASSEEDKLSQN 356
Query: 360 ----ESPSTPLAPSQSQDSVN 376
ES S S S+D +N
Sbjct: 357 ACILESVSEKTERSNSEDKLN 377
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 266 bits (680), Expect = 7e-71
Identities = 143/376 (38%), Positives = 222/376 (59%), Gaps = 16/376 (4%)
Query: 32 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHP 91
P EV++++ +LG+G++G V+KA +KE+G + A K + +S+ L++ I EI I+ CD P
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD--LQEIIKEISIMQQCDSP 80
Query: 92 YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK 151
Y+VK G+Y+ + LWI++E+C G+V I+ ++ L E +I + + L+ L +LH
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Query: 152 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 211
R IHRD+KAGN+L+ EG +LADFGV+ + T+ KR++ IGTP+WMAPEV+ ++
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QE 195
Query: 212 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFL 271
Y+ ADIWSLGIT IEMA+ +PP+ +++PMR + I + PPT P WS +F DF+
Sbjct: 196 IGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFV 255
Query: 272 KIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAV 331
K L KNPE R +A QLL+HPF+ + LR+L+ EA + E+ + E EEE+
Sbjct: 256 KKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEEN 315
Query: 332 DAASTLENHTQNSSEV-SPPSLNADKPLEESPSTPLAPSQSQDSV--------NEPCSQP 382
L++HT + V S ++ A + E T + + + +E +
Sbjct: 316 SDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEE 375
Query: 383 SGDRSLQTTSPPVVAP 398
G TSP V P
Sbjct: 376 DGTMKRNATSPQVQRP 391
Score = 33.5 bits (75), Expect = 0.99
Identities = 45/222 (20%), Positives = 88/222 (39%), Gaps = 26/222 (11%)
Query: 731 KKQELLRD--REAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYN 788
K +LRD EA + + H+ Q+R +++ D+ L H +++ + M+ +
Sbjct: 282 KPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATS 341
Query: 789 ------QRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQ 842
Q MIE + + + E + M + + S QR
Sbjct: 342 TMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNAT------SPQVQRPSFMD 395
Query: 843 FSQQEEKRQKSERLQQQQKHE------NQMRDMLAQCESNMSELQQLQNEKCHLLVEHET 896
+ +++ + KS Q HE N D + + L+N L +E
Sbjct: 396 YFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDG--DFDFLKN----LSLEELQ 449
Query: 897 QKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMF 938
+LKALD + ++E R + +++ + + ++ KKR Q+ F
Sbjct: 450 MRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF 491
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 265 bits (677), Expect = 2e-70
Identities = 150/419 (35%), Positives = 232/419 (55%), Gaps = 29/419 (6%)
Query: 17 KRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE 76
+R+ ++ + P EV++++ +LG+G++G VYKA +KETG + A K + +S+ L+
Sbjct: 11 RRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD--LQ 68
Query: 77 DYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQV 136
+ I EI I+ CD P++VK G+Y+ + LWI++E+C G+V I+ ++ LTE +I
Sbjct: 69 EIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIAT 128
Query: 137 VCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTP 196
+ + L+ L +LH R IHRD+KAGN+L+ EG +LADFGV+ + T+ KR++ IGTP
Sbjct: 129 ILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTP 188
Query: 197 YWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPT 256
+WMAPEV+ ++ Y+ ADIWSLGIT IEMA+ +PP+ +++PMR + I + PPT
Sbjct: 189 FWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPT 243
Query: 257 LLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEA------ 310
P WS F DF+K L K+PE R +A QLL+HPFV S LR+L+ EA
Sbjct: 244 FRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLK 303
Query: 311 -KAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPS 369
+ E++ +E EED +D+ + + V S D PS
Sbjct: 304 RQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPS 363
Query: 370 Q------SQDSVNEPCSQPSGDRSLQTTSPPVVA---------PGNENGLAVPVPLRKS 413
Q + + E + D ++Q P + N G +VP PL+ S
Sbjct: 364 QLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNS 422
Score = 32.3 bits (72), Expect = 2.2
Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 8/119 (6%)
Query: 827 INGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES---NMSELQQL 883
IN E K + + Q K E +Q++K ENQ+ N S+ +
Sbjct: 370 INAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEK-ENQINSFGKSVPGPLKNSSDWKIP 428
Query: 884 QNEKCHLL----VEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMF 938
Q+ L VE ++L ALD Q ++E R K + +++ + + + KKR Q+ F
Sbjct: 429 QDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF 487
Score = 31.6 bits (70), Expect = 3.8
Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 8/105 (7%)
Query: 841 KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHE----- 895
+Q SQQ E Q E ++ + ++ E + + + ++EH+
Sbjct: 304 RQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPS 363
Query: 896 ---TQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEM 937
T + A DE +K + ++P K + E QK++E ++
Sbjct: 364 QLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 251 bits (640), Expect = 3e-66
Identities = 221/875 (25%), Positives = 396/875 (45%), Gaps = 125/875 (14%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
DP E++ + E+G G+FG VY A N T + A K + ++ E+ +D + E++ L
Sbjct: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
Query: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
HP ++ G Y + W+++E+C G A D + + + L E +I + L L +
Sbjct: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALHGLAY 137
Query: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
LHS +IHRD+KAGN+L+T G ++LADFG ++ +SF+GTPYWMAPEV++
Sbjct: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASM----ASPANSFVGTPYWMAPEVILA- 192
Query: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
M + YD K DIWSLGIT IE+A+ +PP +N M L IA++D PTL + ++W+ F
Sbjct: 193 -MDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQS-NEWTDSF 250
Query: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME----------- 316
R F+ L K P+ RP++A+LL H FV + L +L+ K V E
Sbjct: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKK 310
Query: 317 ----EIEDGRDEGEEEDAVDAA----------STLENHTQNSSEVSPPSLNA-----DKP 357
E +G +ED D+ S NH+ S VS S ++ +
Sbjct: 311 ILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEV 370
Query: 358 LEESPSTPLAPSQSQDSVN---------------------EPCSQPSGDRSLQTTSPPVV 396
++ES S + + ++N +P +P +S+Q S +
Sbjct: 371 MDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQ--SQALH 428
Query: 397 APGNENGLAVPVPLRKSRPV-----SMDARIQVAQEKQVAEQ------------GGDLSP 439
E + +R + + R Q++ K++ Q ++
Sbjct: 429 YRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDE 488
Query: 440 AANRSQKASQSRPNSSALETLGGEKLAN---GSLEPPAQAAPGPSKRDSDCSSLCTSESM 496
+ QK ++ N+S++E EKLA +E A+ A K+ + +
Sbjct: 489 HRLKLQKEVETHANNSSIEL---EKLAKKQVAIIEKEAKVAAADEKKFQ--QQILAQQKK 543
Query: 497 DYGTNLSTDL--------SLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKII 548
D T L + + +EM PK K+ K + + +
Sbjct: 544 DLTTFLESQKKQYKICKEKIKEEMNE-DHSTPKKEKQERISKHKENLQHTQAEEEAHLLT 602
Query: 549 SEDEKKDEEMRFLRRQEL-----RELRLLQKEEHRNQTQLSNKH-----------ELQLE 592
+ D+ RF +R+ + E + +++E ++ +TQ +H EL+
Sbjct: 603 QQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYR 662
Query: 593 QMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTR 652
Q+H + ++ + TELEN K++ ++ + H + R++ + ++ + + +
Sbjct: 663 QLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
Query: 653 FQEQLKLMKKEVK----NEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLEL 708
FQ+ K+ K+ K +++E P+ + K +K +E T+K +L + +Q + +
Sbjct: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQY--EQSINEMM 780
Query: 709 AMKRLTTDNRREI-CDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYF 767
A + L D +E C R L ++ ELL ++ + + Q + +H+ Q+L+ +
Sbjct: 781 ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKI----KMQTEAQHERELQKLEQRVS 836
Query: 768 LQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQE 802
L+R L +K E+E +Q+ I+ L RQ++E
Sbjct: 837 LRRAHLEQKIEEELAALQKERSERIKNLLERQERE 871
Score = 68.2 bits (165), Expect = 4e-11
Identities = 83/440 (18%), Positives = 185/440 (42%), Gaps = 72/440 (16%)
Query: 541 SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
+I ++ +++ + E+ LR Q + + ++++ + L NK + ++++ + ++
Sbjct: 437 TIKSASLVTRQIHEHEQENELREQ-MSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQK 495
Query: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQE----Q 656
E+ ELE L ++Q +EK + A ++ ++I +Q +D T F E Q
Sbjct: 496 EVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ 555
Query: 657 LKLMKKEVK---NEVEKLPRQQRKESMKQKME--EHTQKKQLLDRDFVAKQ--------- 702
K+ K+++K NE P+++++E + + E +HTQ ++ + + +Q
Sbjct: 556 YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEE--EAHLLTQQRLYYDKNCR 613
Query: 703 --KEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQ 760
K + + + N RE +K+R + +L + + E+E QL +L
Sbjct: 614 FFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMD 673
Query: 761 QLKDQYFLQ-----------RHELLRKHEKE-----------------------REQMQR 786
++ Q+ + EL RKH E + Q ++
Sbjct: 674 LIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQ 733
Query: 787 YNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAM----YKKSLHINGGGSA--------A 834
Y QL+V + E + K + E ++A+ Y++S++ A A
Sbjct: 734 YKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEA 793
Query: 835 EQREKIKQFSQQEE---KRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLL 891
E + Q Q+ E Q ++Q + +HE +++ + + + L+Q E+ L
Sbjct: 794 ECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAAL 853
Query: 892 VEHETQKLKALDESHNQNLK 911
+ ++++K L E + ++
Sbjct: 854 QKERSERIKNLLERQEREIE 873
Score = 38.5 bits (88), Expect = 0.031
Identities = 41/205 (20%), Positives = 87/205 (42%), Gaps = 18/205 (8%)
Query: 496 MDYGTNLSTDLSLNK----EMGSLSIKDPKLYKKTLK----RTRKFVVDGVEVSITTSKI 547
+ + T L L NK E+ + + + K LK + +K D +V K
Sbjct: 677 LQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKA 736
Query: 548 ISEDE----KKDEE---MRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
+ + K+E ++ L+ ++ R+L +L ++ ++ ++ L+L++ E
Sbjct: 737 LKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQ---EA 793
Query: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM 660
E A + E+E L Q + + E H ++ +R+ L + + +E+L +
Sbjct: 794 ECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAAL 853
Query: 661 KKEVKNEVEKLPRQQRKESMKQKME 685
+KE ++ L +Q +E ME
Sbjct: 854 QKERSERIKNLLERQEREIETFDME 878
Score = 35.8 bits (81), Expect = 0.20
Identities = 49/221 (22%), Positives = 95/221 (42%), Gaps = 23/221 (10%)
Query: 717 NRREICDKERECLMKKQELLRDREAALWEM----EEHQLQERHQLVKQQLKDQYFLQRHE 772
NR + L+ +Q ++E L E + + Q + QL+ + K + + H
Sbjct: 431 NRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHR 490
Query: 773 LLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTR----MAMYKKSLHIN 828
L K +KE E + +E+L +Q + K+ ++ K +A KK L
Sbjct: 491 L--KLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTF 548
Query: 829 GGGSAAEQR---EKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQN 885
+ + EKIK+ ++ K E+ ++ KH+ ++ A+ E+++ Q+L
Sbjct: 549 LESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYY 608
Query: 886 EK-CHLLVEHETQKLKALDESH---NQNLKEWRDKLRPRKK 922
+K C K K + + H QN++E +K R +K+
Sbjct: 609 DKNCRFF------KRKIMIKRHEVEQQNIREELNKKRTQKE 643
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 249 bits (637), Expect = 7e-66
Identities = 145/377 (38%), Positives = 223/377 (59%), Gaps = 18/377 (4%)
Query: 21 REYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYI 79
R + + +DP E++ + +G G+FG+VYK + T + A K+I+ + +E+E+ED
Sbjct: 5 RGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ 64
Query: 80 VEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCR 139
EI +L+ CD PYI + G+Y KLWI++E+ GG+ A+ L L E I + R
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGS--ALDLLKPGPLEETYIATILR 122
Query: 140 QMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWM 199
++L+ L++LHS+R IHRD+KA NVL++ +GD++LADFGV+ + T KR++F+GTP+WM
Sbjct: 123 EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 182
Query: 200 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259
APEV+ K + YD+KADIWSLGIT IE+A+ EPP+ +L+PMRVL I K+ PPTL
Sbjct: 183 APEVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTL-- 235
Query: 260 PSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-LRELVAEAKAEVMEEI 318
+ S F++F++ L+K+P RP+A +LL+H F++ T + L EL+ K E
Sbjct: 236 EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-- 293
Query: 319 EDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEP 378
G + E+ +D + E+ Q PP++ + T L SQ EP
Sbjct: 294 GHGEESSSEDSDIDGEA--EDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKP---AEP 348
Query: 379 CSQPSGDRSLQTTSPPV 395
+ + L T PV
Sbjct: 349 VKRQPRSQCLSTLVRPV 365
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 246 bits (628), Expect = 7e-65
Identities = 220/918 (23%), Positives = 421/918 (45%), Gaps = 101/918 (11%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
DP +++ + E+G G+FG VY A++ T + A K + +S E+ +D I E++ L
Sbjct: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
Query: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
HP ++ G Y + W+++E+C G A D + + + L E +I + L+ L +
Sbjct: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALQGLAY 141
Query: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
LHS +IHRD+KAGN+L+T G ++LADFG + +SF+GTPYWMAPEV++
Sbjct: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVIL-- 195
Query: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ PTL + ++WS F
Sbjct: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQS-NEWSDYF 254
Query: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME----------- 316
R+F+ L K P+ RP++ +LL+H FV L +L+ K V E
Sbjct: 255 RNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK 314
Query: 317 ----------EIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPL 366
+E +E E++ V T+ + N S + S++A +S S
Sbjct: 315 LLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQS-IPSMSISAS---SQSSSVNS 370
Query: 367 APSQSQDSVNEPCSQPSGDRSLQTTSPPV-VAPGNENGLAVPVP-LRKSRPVSMDARIQV 424
P S D GD ++ + S + + P EN P R S P S +
Sbjct: 371 LPDVSDD--KSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRH 428
Query: 425 AQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
+ E + A+ +++ + +S E + G K + K +
Sbjct: 429 KSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAE 488
Query: 485 SDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITT 544
D L D L + + + + KL KK K
Sbjct: 489 MD------------EHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEK-----------E 525
Query: 545 SKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINA 604
+K++S +EKK ++ ++ Q+ +EL + + R +++L+ EQ+ + + +
Sbjct: 526 AKVMSNEEKKFQQ--HIQAQQKKELNSFLESQKR-------EYKLRKEQLKEELNENQST 576
Query: 605 KKKFFDTELENLERQQ--KQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKK 662
KK E+Q+ +Q E ++ A RR R + + RF+ ++ L +
Sbjct: 577 PKK---------EKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRH 627
Query: 663 EVKNEV--EKLPRQQRKESMKQKM--EEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNR 718
++ ++ E+L ++Q ++ ++ M +H ++L R QK EL + T+
Sbjct: 628 NLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELT 687
Query: 719 REI-CDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQ--RHELLR 775
++ +K RE ++++ ++ R+ + L+ + +K+Q +D +Q +++ LR
Sbjct: 688 NQLEYNKRRERELRRKHVMEVRQ------QPKSLKSKELQIKKQFQDTCKIQTRQYKALR 741
Query: 776 KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAE 835
H E + + ++++LK Q ++ A L ++ + + ++L ++ A
Sbjct: 742 NHLLETTPKSEH-KAVLKRLKEEQTRKLAIL--AEQYDHSINEMLSTQALRLDEAQEAEC 798
Query: 836 Q--REKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVE 893
Q + +++Q + Q ++Q + +H+ ++R++ + + L+Q E+ L
Sbjct: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
Query: 894 HETQKLKALDESHNQNLK 911
T+++++L E + ++
Sbjct: 859 ERTERIRSLLERQAREIE 876
Score = 88.2 bits (217), Expect = 3e-17
Identities = 92/442 (20%), Positives = 209/442 (47%), Gaps = 55/442 (12%)
Query: 541 SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
+I T+ +++ ++ E+ LR Q + + ++++ + L NK + ++++ R ++
Sbjct: 440 TIRTASLVTRQMQEHEQDSELREQ-MSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDK 498
Query: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQE----Q 656
++ ++ F E+E L ++ + +EK + + ++ + I+ +Q ++ F E +
Sbjct: 499 DLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKRE 558
Query: 657 LKLMKKEVK---NEVEKLPRQQRKESMKQKME--EHTQKKQLLDRDFVAKQKEDLELAMK 711
KL K+++K NE + P+++++E + ++ E +H Q ++ + + + +Q++ LEL +
Sbjct: 559 YKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEE--EANLLRRQRQYLELECR 616
Query: 712 RLTTDNRREIC-------DKERECLMKKQELLRDREAALWEMEEHQLQE---RHQLVKQQ 761
R RR + D RE L K+Q +D E A+ + +QE RH Q+
Sbjct: 617 RF---KRRMLLGRHNLEQDLVREELNKRQTQ-KDLEHAMLLRQHESMQELEFRHLNTIQK 672
Query: 762 LKDQYFLQRHELLR-KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAM 820
+ R EL+R +H+ E YN+R +L+ + E + PK +S+
Sbjct: 673 M-------RCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQ 725
Query: 821 YKKSLHINGGGSAAEQREKIKQFSQQEEK----RQKSERLQQ----QQKHENQMRDMLAQ 872
++ + I A + ++ + E K R K E+ ++ +++++ + +ML+
Sbjct: 726 FQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLST 785
Query: 873 CESNMSELQQLQNEKCHLLVEHETQKLKAL--------DESHNQNLKEWRDKLRPRKKAL 924
+ E Q+ + + + ++ E + L A + H++ L+E ++ R+ L
Sbjct: 786 QALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALL 845
Query: 925 EEDLNQKKREQEMFFKLSEEAE 946
E+ K E+EM +E E
Sbjct: 846 EQ-----KIEEEMLALQNERTE 862
Score = 33.5 bits (75), Expect = 0.99
Identities = 67/360 (18%), Positives = 134/360 (37%), Gaps = 45/360 (12%)
Query: 606 KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRL-EQDRDYTRFQEQLKL--MKK 662
+ F D+ L+ + + + E ++ +R R E I L ++ +D R + L+ MKK
Sbjct: 255 RNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK 314
Query: 663 EVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQK---EDLELAMKRLTTDNRR 719
+ E P + +E +++ ++H + + Q + + + + ++
Sbjct: 315 LLFQEAHNGPAVEAQE--EEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLP 372
Query: 720 EICDKEREC-LMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHE 778
++ D + E +M+ + + + E + + + D Q + +H+
Sbjct: 373 DVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDP---QSPPQVSRHK 429
Query: 779 KEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQRE 838
+ + L RQ QE Q SE + +M+ YK+ +R+
Sbjct: 430 SHYRNREHFATIRTASLVTRQMQEHE-----QDSELREQMSGYKRM-----------RRQ 473
Query: 839 KIKQFSQQEEK---RQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHE 895
KQ E K RL+ + E Q + A+ E L+ +H+
Sbjct: 474 HQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEK--------------LIKKHQ 519
Query: 896 TQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSK 955
K N+ K + +KK L L +KRE ++ + +E N STP K
Sbjct: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 246 bits (627), Expect = 1e-64
Identities = 241/944 (25%), Positives = 416/944 (44%), Gaps = 150/944 (15%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
DP +++ + E+G G+FG VY A++ + A K + +S E+ +D I E+ L
Sbjct: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
Query: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
HP ++ G Y + W+++E+C G A D + + + L E +I V L+ L +
Sbjct: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
Query: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
LHS +IHRD+KAGN+L++ G ++L DFG ++ + +SF+GTPYWMAPEV++
Sbjct: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVILA- 196
Query: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ P +L WS F
Sbjct: 197 -MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESP-VLQSGHWSEYF 254
Query: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE 327
R+F+ L K P+ RP++ LL+H FV LRE +M+ I+ +D E
Sbjct: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFV--------LRE---RPPTVIMDLIQRTKDAVRE 303
Query: 328 EDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTP-LAPSQSQDSVNEPCSQPSG-- 384
D + + Q +P A+ P EE + P + + + S+ S PS
Sbjct: 304 LDNLQYRKMKKILFQE----APNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSI 359
Query: 385 DRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRS 444
S Q++S +A ++N + + +E++ E+G + A
Sbjct: 360 SASSQSSSVNSLADASDN----------------EEEEEEEEEEEEEEEGPEAREMAMMQ 403
Query: 445 QKASQSRPNSSALETLGGE----------KLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
+ +SS + L G ++ L+PP AAP P+ S
Sbjct: 404 EGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPP--AAPAPTSTTSSARRRAYCR 461
Query: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
+ D+ +I T+ ++S ++
Sbjct: 462 NRDH----------------------------------------FATIRTASLVSRQIQE 481
Query: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
E+ LR Q L + ++++ + L ++ + E+ R ++E+ A++ F E E
Sbjct: 482 HEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQ-LKLMKKEVKN--EVEKL 671
L R+ + EK EAR + E+ +FQ+ L KKE+ E +K
Sbjct: 541 KLARRHQAIGEK-----------EARAAQAEE----RKFQQHILGQQKKELAALLEAQKR 585
Query: 672 PRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTD-NRREICDKERECLM 730
+ RKE +K++++E+ + +++ +QKE L+ RR+ E +C
Sbjct: 586 TYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQ 645
Query: 731 KKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQR 790
K+++L R + ++ L + KQ KD L+ LLR+HE RE R Q
Sbjct: 646 YKRKMLLARHSLDQDLLREDLNK-----KQTQKD---LECALLLRQHEATRELELRQLQA 697
Query: 791 MIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKR 850
+ Q+ +A L ++Q Y K E R+K +Q+ K
Sbjct: 698 V--------QRTRAELTRLQHQTELGNQLEYNKR-------REQELRQKHAAQVRQQPKS 742
Query: 851 QKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCH-----LLVEHETQKLKALDES 905
KS+ LQ +++ + + Q ++ + L + + H L E +T+KL L E
Sbjct: 743 LKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQ 802
Query: 906 HNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPN 949
++Q++ E +AL D Q+ Q + +L +E E N
Sbjct: 803 YDQSISEMLS-----SQALRLDETQEAEFQALRQQLQQELELLN 841
Score = 37.4 bits (85), Expect = 0.068
Identities = 29/129 (22%), Positives = 62/129 (48%), Gaps = 21/129 (16%)
Query: 523 YKKTLKR-----TRKFVVDGVEVSITTSKIISE-----DEKKDEEMRFLRRQELRELRLL 572
+K LKR TRK + + + S+++S DE ++ E + LR+Q +EL LL
Sbjct: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
Query: 573 QKEEHRNQTQLSNKHELQLEQ-----------MHKRFEQEINAKKKFFDTELENLERQQK 621
+ + + + ++HE +L + + +R E+E+ A + + +L +Q
Sbjct: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
Query: 622 QQVEKMEQD 630
+++E + +
Sbjct: 901 REIEAFDAE 909
Score = 35.8 bits (81), Expect = 0.20
Identities = 36/172 (20%), Positives = 82/172 (47%), Gaps = 20/172 (11%)
Query: 510 KEMGSLSIKDPKLYKKTLK-RTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRE 568
K + S ++ K +++T K +TR++ + TT K + ++ L+ ++ R+
Sbjct: 741 KSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKA-----QHKSLLKRLKEEQTRK 795
Query: 569 LRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENL-----------E 617
L +L ++ ++ +++ + L+L++ E E A ++ ELE L E
Sbjct: 796 LAILAEQYDQSISEMLSSQALRLDETQ---EAEFQALRQQLQQELELLNAYQSKIKIRTE 852
Query: 618 RQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVE 669
Q ++++ ++EQ A+RR +R+ E T E+++ + + E+E
Sbjct: 853 SQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIE 904
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 245 bits (625), Expect = 2e-64
Identities = 164/470 (34%), Positives = 246/470 (52%), Gaps = 26/470 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
+P + +E+V +G G +G VYKA+N TG LAA K+I+ + ++ EI ++ C H
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
IV G+Y KLWI +E+C GG++ I + L+E QI VCR+ L+ L +LH+
Sbjct: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
K +HRD+K N+L+T GD++LADFGV+AK T+ KR SFIGTPYWMAPEV E K
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268
+ Y+ DIW++GIT IE+ +++PP +L+PMR L ++KS+ PP L +KWS F
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALR-ELVAEAKAEVMEEIEDGRDEGEE 327
+F+KIAL KNP+ RP+A +LL H FV+ ++AL EL+ + D+ +
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDF 311
Query: 328 EDAVDAASTLENHTQNS-SEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDR 386
E T+ + +N+ +E + +N DK E P ++ + + S D
Sbjct: 312 EPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL-------SSDP 364
Query: 387 SLQTTSPPVVAPGN----ENGLAVPVPLRKSRPVSMDARIQVAQEKQVA-----EQGGDL 437
+ P V N + A+P PL +S E++ +
Sbjct: 365 NFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESR 424
Query: 438 SPAANRSQKASQSRP---NSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
+P R Q + P SS G KL + + E AQA P K+D
Sbjct: 425 APQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKD 474
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 245 bits (625), Expect = 2e-64
Identities = 164/470 (34%), Positives = 246/470 (52%), Gaps = 26/470 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
+P + +E+V +G G +G VYKA+N TG LAA K+I+ + ++ EI ++ C H
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
IV G+Y KLWI +E+C GG++ I + L+E QI VCR+ L+ L +LH+
Sbjct: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
K +HRD+K N+L+T GD++LADFGV+AK T+ KR SFIGTPYWMAPEV E K
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268
+ Y+ DIW++GIT IE+ +++PP +L+PMR L ++KS+ PP L +KWS F
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALR-ELVAEAKAEVMEEIEDGRDEGEE 327
+F+KIAL KNP+ RP+A +LL H FV+ ++AL EL+ + D+ +
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDF 311
Query: 328 EDAVDAASTLENHTQNS-SEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDR 386
E T+ + +N+ +E + +N DK E P ++ + + S D
Sbjct: 312 EPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL-------SSDP 364
Query: 387 SLQTTSPPVVAPGN----ENGLAVPVPLRKSRPVSMDARIQVAQEKQVA-----EQGGDL 437
+ P V N + A+P PL +S E++ +
Sbjct: 365 NFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESR 424
Query: 438 SPAANRSQKASQSRP---NSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
+P R Q + P SS G KL + + E AQA P K+D
Sbjct: 425 APQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKD 474
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 244 bits (623), Expect = 3e-64
Identities = 136/337 (40%), Positives = 196/337 (58%), Gaps = 10/337 (2%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
+P E +E++ +G G +G VYKA+N TG LAA KVI+ + E+ EI ++ C H
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
P IV G+Y KLWI +EFC GG++ I + L+E QI V R+ L+ L +LHS
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIAYVSRETLQGLYYLHS 129
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
K +HRD+K N+L+T G ++LADFGVSA+ T+ KR SFIGTPYWMAPEV E +
Sbjct: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--R 187
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268
Y+ D+W++GIT IE+A+++PP +L+PMR L + KS+ PP L KWS F
Sbjct: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE- 327
F+K+AL KNP+ RP+A +LL+HPFV+ + EL+ + D D+ E
Sbjct: 248 HFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEP 307
Query: 328 ----EDAVDAASTLENHTQNSSEVSPPSLNADKPLEE 360
+ + S + SE++ + D PL +
Sbjct: 308 LVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRK 344
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 243 bits (619), Expect = 8e-64
Identities = 122/282 (43%), Positives = 181/282 (64%), Gaps = 5/282 (1%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP + +E++ +G G +G VYKA++ T LAA K+++ +++ EI IL C H
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
P +V +G+Y + +LWI +EFC GG++ I L E QI VCR+ L+ L+ LHS
Sbjct: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY-HATGPLEERQIAYVCREALKGLHHLHS 129
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
+ IHRD+K N+L+TL+GD++LADFGVS + ++ KR SFIGTPYWMAPEV E +
Sbjct: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--R 187
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268
Y+ D+W+LGIT IE+ +++PP L+PMR L+ ++KS PP L ++W+ F
Sbjct: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEA 310
FLK+AL KNP+ RP+A +LL+HPF + L +L+ +A
Sbjct: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKA 289
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 241 bits (615), Expect = 2e-63
Identities = 129/302 (42%), Positives = 196/302 (64%), Gaps = 12/302 (3%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYIVEIEILATCD 89
DP E++ + ++G G+FG+V+K + T + A K+I+ + +E+E+ED EI +L+ CD
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 90 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 149
PY+ K G+Y D KLWI++E+ GG+ A+ L L E QI + R++L+ L++LH
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGS--ALDLLEPGPLDETQIATILREILKGLDYLH 136
Query: 150 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 209
S++ IHRD+KA NVL++ G+++LADFGV+ + T KR++F+GTP+WMAPEV+
Sbjct: 137 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 191
Query: 210 KDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRD 269
K + YD KADIWSLGIT IE+A+ EPPH EL+PM+VL I K++PPTL +S ++
Sbjct: 192 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL--EGNYSKPLKE 249
Query: 270 FLKIALDKNPETRPSAAQLLEHPFV-SSITSNKALRELVAEAKAEVMEEIEDGRDEGEEE 328
F++ L+K P RP+A +LL+H F+ + L EL+ K E+ D E+
Sbjct: 250 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD-SSSEDS 308
Query: 329 DA 330
DA
Sbjct: 309 DA 310
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 241 bits (615), Expect = 2e-63
Identities = 129/302 (42%), Positives = 196/302 (64%), Gaps = 12/302 (3%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYIVEIEILATCD 89
DP E++ + ++G G+FG+V+K + T + A K+I+ + +E+E+ED EI +L+ CD
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 90 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 149
PY+ K G+Y D KLWI++E+ GG+ A+ L L E QI + R++L+ L++LH
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGS--ALDLLEPGPLDETQIATILREILKGLDYLH 148
Query: 150 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 209
S++ IHRD+KA NVL++ G+++LADFGV+ + T KR++F+GTP+WMAPEV+
Sbjct: 149 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 203
Query: 210 KDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRD 269
K + YD KADIWSLGIT IE+A+ EPPH EL+PM+VL I K++PPTL +S ++
Sbjct: 204 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL--EGNYSKPLKE 261
Query: 270 FLKIALDKNPETRPSAAQLLEHPFV-SSITSNKALRELVAEAKAEVMEEIEDGRDEGEEE 328
F++ L+K P RP+A +LL+H F+ + L EL+ K E+ D E+
Sbjct: 262 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD-SSSEDS 320
Query: 329 DA 330
DA
Sbjct: 321 DA 322
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 240 bits (612), Expect = 5e-63
Identities = 118/276 (42%), Positives = 171/276 (61%), Gaps = 10/276 (3%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC-D 89
DP + WEI+ +G G +GKVYK NK G+LAA K+++ S+ + E+ E IL +
Sbjct: 22 DPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMD-EEIEAEYNILQFLPN 80
Query: 90 HPYIVKLLGAYYH-----DGKLWIMIEFCPGGAVDAI---MLELDRGLTEPQIQVVCRQM 141
HP +VK G +Y G+LW+++E C GG+V + +L + L E I +
Sbjct: 81 HPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGA 140
Query: 142 LEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 201
L L LH+ RIIHRD+K N+L+T EG ++L DFGVSA+ T +R++ +GTP+WMAP
Sbjct: 141 LLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAP 200
Query: 202 EVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPS 261
EV+ CE D+ YD + D+WSLGIT IE+ +PP +++P++ L KI ++ PPTLL P
Sbjct: 201 EVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPE 260
Query: 262 KWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 297
KW EF F+ L K+ E RPS LL+HPF+ +
Sbjct: 261 KWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGV 296
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 240 bits (612), Expect = 5e-63
Identities = 118/276 (42%), Positives = 171/276 (61%), Gaps = 10/276 (3%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC-D 89
DP + WEI+ +G G +GKVYK NK G+LAA K+++ S+ + E+ E IL +
Sbjct: 22 DPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMD-EEIEAEYNILQFLPN 80
Query: 90 HPYIVKLLGAYYH-----DGKLWIMIEFCPGGAVDAI---MLELDRGLTEPQIQVVCRQM 141
HP +VK G +Y G+LW+++E C GG+V + +L + L E I +
Sbjct: 81 HPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGA 140
Query: 142 LEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 201
L L LH+ RIIHRD+K N+L+T EG ++L DFGVSA+ T +R++ +GTP+WMAP
Sbjct: 141 LLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAP 200
Query: 202 EVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPS 261
EV+ CE D+ YD + D+WSLGIT IE+ +PP +++P++ L KI ++ PPTLL P
Sbjct: 201 EVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPE 260
Query: 262 KWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 297
KW EF F+ L K+ E RPS LL+HPF+ +
Sbjct: 261 KWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGV 296
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 238 bits (608), Expect = 2e-62
Identities = 121/278 (43%), Positives = 174/278 (62%), Gaps = 14/278 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIET--KSEEELEDYIVEIEIL-AT 87
DP++ WEI +G G +GKV+K NK+ G AA K+++ +EE+E E IL A
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIE---AEYNILKAL 72
Query: 88 CDHPYIVKLLGAYY-----HDGKLWIMIEFCPGGAV-DAIMLELDRG--LTEPQIQVVCR 139
DHP +V+ G Y+ + KLW+++E C GG+V D + L RG ++EP I +
Sbjct: 73 SDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILH 132
Query: 140 QMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWM 199
+ L L LH+ + IHRD+K N+L+T EG ++L DFGVSA+ T +R++ +GTP+WM
Sbjct: 133 EALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWM 192
Query: 200 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259
APEV+ CE DT YD + D WSLGIT IE+ +PP +L+PMR L KI ++ PP L
Sbjct: 193 APEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQ 252
Query: 260 PSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 297
P WS EF DF+ L K+ E RP+ ++LL+H F++ I
Sbjct: 253 PELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQI 290
Score = 32.0 bits (71), Expect = 2.9
Identities = 70/357 (19%), Positives = 130/357 (36%), Gaps = 66/357 (18%)
Query: 648 RDYTRFQEQLKLMKKEVKNEVE-KLPRQQRKESMKQKM----------EEHTQKKQLLD- 695
R Y + QE+ K +++ L R+QRKE + K +E KK +
Sbjct: 1073 RRYQKIQEKRKESAIIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENT 1132
Query: 696 -RDFVAKQKEDLELAMKRLTT--DNRREICDKERECLMKKQELLRDREA---------AL 743
FV KQ E+ A +R + +N+ + + ++E E+ +
Sbjct: 1133 RESFVKKQAENAISANERFISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKM 1192
Query: 744 WEMEEHQLQERHQLVKQQL----KDQYFLQRHELLRKHEKEREQMQRYNQRMIEQ----- 794
+ E ++++ LV ++ K L+ + LRK EKE +Q Y QR E+
Sbjct: 1193 NNVYEEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEE 1252
Query: 795 -----LKVRQQQEKARLPKIQRSEGKTRM------AMYKKSLHINGGGSAAEQREKI--- 840
L+ + E+ P +E +T + ++S++ N E++ +
Sbjct: 1253 SKAAYLERKAISERPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQ 1312
Query: 841 -KQFSQQEE----------KRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCH 889
QEE K ++ E + Q Q+ E++ + QQL+ +K
Sbjct: 1313 RAPICSQEEGRGRLRHETVKERQVEPVTQAQEEEDKAAVFIQSKYRGYKRRQQLRKDKMS 1372
Query: 890 LLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAE 946
+ NL + K E++N K++ K + E E
Sbjct: 1373 SFKHQRIVTTPTEVARNTHNLYSYPTK--------HEEINNIKKKDNKDSKATSERE 1421
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 236 bits (602), Expect = 8e-62
Identities = 142/370 (38%), Positives = 212/370 (57%), Gaps = 19/370 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP + ++++ LG G +G+V+KA++K +G L A K+++ + ++++ EI IL TC H
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
IV G+Y KLWI +EFC G++ I ++ L+E QI VCR++L+ L +LHS
Sbjct: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
++ IHRD+K N+L+ G++RLADFG+SA+ TL +R SFIGTPYWMAPEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268
Y+ DIWSLGIT IE+A+++PP +++P+RVL + KS PP L KWS F
Sbjct: 191 G--YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-----LRELVAEAKAEVMEEIEDGRD 323
+F+K+ L K+P+ RPSA ++L H VS N+ L +L K + +IED
Sbjct: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIED--- 305
Query: 324 EGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPS 383
EE + A T SS + P +AD L +++ N QP
Sbjct: 306 --EEPELPPAIPRRIRSTHRSSSLGIP--DADCCRRHMEFRKLRGMETRPPANTARLQP- 360
Query: 384 GDRSLQTTSP 393
R L+++SP
Sbjct: 361 -PRDLRSSSP 369
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 236 bits (602), Expect = 8e-62
Identities = 142/370 (38%), Positives = 212/370 (57%), Gaps = 19/370 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP + ++++ LG G +G+V+KA++K +G L A K+++ + ++++ EI IL TC H
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
Query: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
IV G+Y KLWI +EFC G++ I ++ L+E QI VCR++L+ L +LHS
Sbjct: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
++ IHRD+K N+L+ G++RLADFG+SA+ TL +R SFIGTPYWMAPEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268
Y+ DIWSLGIT IE+A+++PP +++P+RVL + KS PP L KWS F
Sbjct: 191 G--YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
Query: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-----LRELVAEAKAEVMEEIEDGRD 323
+F+K+ L K+P+ RPSA ++L H VS N+ L +L K + +IED
Sbjct: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIED--- 305
Query: 324 EGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPS 383
EE + A T SS + P +AD L +++ N QP
Sbjct: 306 --EEPELPPAIPRRIRSTHRSSSLGIP--DADCCRRHMEFRKLRGMETRPPANTARLQP- 360
Query: 384 GDRSLQTTSP 393
R L+++SP
Sbjct: 361 -PRDLRSSSP 369
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 234 bits (597), Expect = 3e-61
Identities = 128/315 (40%), Positives = 203/315 (64%), Gaps = 17/315 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYIVEIEILATCD 89
DP E++ + +G G+FG+V+K + T + A K+I+ + +E+E+ED EI +L+ CD
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 90 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRG--LTEPQIQVVCRQMLEALNF 147
Y+ K G+Y KLWI++E+ GG+ L+L R E QI + +++L+ L++
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSA----LDLLRAGPFDEFQIATMLKEILKGLDY 134
Query: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
LHS++ IHRD+KA NVL++ +GD++LADFGV+ + T KR++F+GTP+WMAPEV+
Sbjct: 135 LHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 191
Query: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
+ + YD KADIWSLGIT IE+A+ EPP+ +++PMRVL I K++PPTL+ ++ F
Sbjct: 192 --QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV--GDFTKSF 247
Query: 268 RDFLKIALDKNPETRPSAAQLLEHPF-VSSITSNKALRELVAEAKAEVMEEIEDGRDEGE 326
++F+ L+K+P RP+A +LL+H F V + L EL+ K E D DE +
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSD--DESD 305
Query: 327 EEDAVDAASTLENHT 341
E + +++ EN+T
Sbjct: 306 SEGSDSESTSRENNT 320
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 229 bits (583), Expect = 1e-59
Identities = 210/818 (25%), Positives = 371/818 (45%), Gaps = 121/818 (14%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
DP +++ + E+G G+FG VY A++ + A K + +S E+ +D I E+ L
Sbjct: 23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 82
Query: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
HP ++ G Y + W+++E+C G A D + + + L E +I V L+ L +
Sbjct: 83 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAY 141
Query: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
LHS +IHRD+KAGN+L++ G ++L DFG ++ + +SF+GTPYWMAPEV++
Sbjct: 142 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVILA- 196
Query: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ P +L WS F
Sbjct: 197 -MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESP-VLQSGHWSEYF 254
Query: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE 327
R+F+ L K P+ RP++ LL+H FV LRE +M+ I+ +D E
Sbjct: 255 RNFVDSCLQKIPQDRPTSEVLLKHRFV--------LRE---RPPTVIMDLIQRTKDAVRE 303
Query: 328 EDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTP-LAPSQSQDSVNEPCSQPSG-- 384
D + + Q +P A+ P EE + P + + + S+ S PS
Sbjct: 304 LDNLQYRKMKKILFQE----APNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSI 359
Query: 385 DRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRS 444
S Q++S +A ++N + + +E++ E+G + A
Sbjct: 360 SASSQSSSVNSLADASDN----------------EEEEEEEEEEEEEEEGPEAREMAMMQ 403
Query: 445 QKASQSRPNSSALETLGGE----------KLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
+ +SS + L G ++ L+PP AAP P+ S
Sbjct: 404 EGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPP--AAPAPTSTTSSARRRAYCR 461
Query: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
+ D+ +I T+ ++S ++
Sbjct: 462 NRDH----------------------------------------FATIRTASLVSRQIQE 481
Query: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
E+ LR Q L + ++++ + L ++ + E+ R ++E+ A++ F E E
Sbjct: 482 HEQDSALREQ-LSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQE----QLKLMKKEVKNEVEK 670
L R+ + EK + R+ + I +Q ++ E KL K+++K E+++
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 671 ---LPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDN--RREICDKE 725
P++++ E + ++ E+ Q + + + +Q++ EL ++ R D++
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 726 --RECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR-KHEKERE 782
RE L KKQ +D E AL + +H+ +L + Q + R EL R +H+ E
Sbjct: 661 LLREDLNKKQ-TQKDLECALL-LRQHEATRELELRQLQAVQR---TRAELTRLQHQTELG 715
Query: 783 QMQRYNQRMIEQLK------VRQQQEKARLPKIQRSEG 814
YN+R ++L+ VRQQ + ++ QR G
Sbjct: 716 NQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPG 753
Score = 53.5 bits (127), Expect = 9e-07
Identities = 84/406 (20%), Positives = 166/406 (40%), Gaps = 59/406 (14%)
Query: 550 EDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFF 609
E+E+++EE E RE+ ++Q+ EH + S H L N +
Sbjct: 380 EEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSD---------NLYDDPY 430
Query: 610 DTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVE 669
E+ Q + RRR R +RD+ L+ ++++ +
Sbjct: 431 QPEITPSPLQPPAAPAPTSTTSSARRRAYCR------NRDHFATIRTASLVSRQIQEHEQ 484
Query: 670 KLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECL 729
+++ K+ +H +KQLL + + + + A + + +R E E L
Sbjct: 485 DSALREQLSGYKRMRRQH--QKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKL 542
Query: 730 MKKQELLRDREAALWEMEEHQLQER-------------------HQLVKQQLKDQYFLQR 770
++ + + ++EA + EE + Q+ ++L K+QLK++ LQ
Sbjct: 543 ARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEE--LQE 600
Query: 771 HELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGG 830
+ K EK + R EQL+ Q +E+A L + QR + + YK+ + +
Sbjct: 601 NPSTPKREKAEWLL-----RQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL--- 652
Query: 831 GSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890
R + Q +E+ +K + Q+ + +R A E + +LQ +Q + L
Sbjct: 653 -----ARHSLDQDLLREDLNKK--QTQKDLECALLLRQHEATRELELRQLQAVQRTRAEL 705
Query: 891 L-VEHETQKLKALDESHNQNLKEWRDK----LRPRKKALEEDLNQK 931
++H+T+ L E + + +E R K +R + K+L+ Q+
Sbjct: 706 TRLQHQTELGNQL-EYNKRREQELRQKHAAQVRQQPKSLKVRAGQR 750
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 57.4 bits (137), Expect = 6e-08
Identities = 72/337 (21%), Positives = 148/337 (43%), Gaps = 21/337 (6%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 K-------HEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHIN 828
+ HE+E ++ Q QR E+L+ + +QE+ L +Q + R K H
Sbjct: 434 EEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYK 493
Query: 829 GGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQ 865
G S +E+ K+ + + L Q Q
Sbjct: 494 EGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQ 530
Score = 38.5 bits (88), Expect = 0.031
Identities = 60/290 (20%), Positives = 123/290 (42%), Gaps = 61/290 (21%)
Query: 684 MEEHTQK---KQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDRE 740
++ H+Q+ +QL+ F+ Q + ++ ++ ++ D+ ++ +K E +
Sbjct: 271 VKNHSQRPATEQLMKHPFIRDQPNERQVRIQL------KDHIDRTKKKRGEKDETEYEYS 324
Query: 741 AALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ 800
+ E EE+ E ++ L + L+R + LR +E+ + ++ +EQ + +
Sbjct: 325 GSEEEEEENDSGEPSSILN--LPGESTLRR-DFLRLQLANKERSEALRRQQLEQQQRENE 381
Query: 801 QEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQ 860
+ K +L AE++++I EE++++ RL++QQ
Sbjct: 382 EHKRQL--------------------------LAERQKRI------EEQKEQRRRLEEQQ 409
Query: 861 KHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQ-KLKALDESH-----NQNLKEWR 914
+ E ++R + E +Q++ E+ EHE + K K L+E + LK+ R
Sbjct: 410 RREKELRKQ-QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER 468
Query: 915 DKLRPRKKALEEDLNQKKREQEMFFK--LSEEAECPNPSTPSKAAKFFPY 962
D L L +++EQ K L E +PS AK P+
Sbjct: 469 DYL--------VSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPH 510
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 57.4 bits (137), Expect = 6e-08
Identities = 72/337 (21%), Positives = 148/337 (43%), Gaps = 21/337 (6%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 K-------HEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHIN 828
+ HE+E ++ Q QR E+L+ + +QE+ L +Q + R K H
Sbjct: 434 EEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYK 493
Query: 829 GGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQ 865
G S +E+ K+ + + L Q Q
Sbjct: 494 EGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQ 530
Score = 38.5 bits (88), Expect = 0.031
Identities = 60/290 (20%), Positives = 123/290 (42%), Gaps = 61/290 (21%)
Query: 684 MEEHTQK---KQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDRE 740
++ H+Q+ +QL+ F+ Q + ++ ++ ++ D+ ++ +K E +
Sbjct: 271 VKNHSQRPATEQLMKHPFIRDQPNERQVRIQL------KDHIDRTKKKRGEKDETEYEYS 324
Query: 741 AALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ 800
+ E EE+ E ++ L + L+R + LR +E+ + ++ +EQ + +
Sbjct: 325 GSEEEEEENDSGEPSSILN--LPGESTLRR-DFLRLQLANKERSEALRRQQLEQQQRENE 381
Query: 801 QEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQ 860
+ K +L AE++++I EE++++ RL++QQ
Sbjct: 382 EHKRQL--------------------------LAERQKRI------EEQKEQRRRLEEQQ 409
Query: 861 KHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQ-KLKALDESH-----NQNLKEWR 914
+ E ++R + E +Q++ E+ EHE + K K L+E + LK+ R
Sbjct: 410 RREKELRKQ-QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER 468
Query: 915 DKLRPRKKALEEDLNQKKREQEMFFK--LSEEAECPNPSTPSKAAKFFPY 962
D L L +++EQ K L E +PS AK P+
Sbjct: 469 DYL--------VSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPH 510
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 58.2 bits (139), Expect = 4e-08
Identities = 96/441 (21%), Positives = 184/441 (41%), Gaps = 64/441 (14%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 KHEKER-EQMQRYNQRMIE----QLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGG 830
+ E+ R E Q Y +R +E QL++ QQQ LH
Sbjct: 434 EEERRRAEHEQEYIRRQLEEEQRQLEILQQQ----------------------LLH---- 467
Query: 831 GSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890
EQ ++ +Q E+++++ERLQ+Q K E RD L + E + ++ + +
Sbjct: 468 ----EQALLLEYKRKQLEEQRQAERLQRQLKQE---RDYLVSLQHQRQEQRPVEKKPLYH 520
Query: 891 LVEHETQKLK---ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAEC 947
E + K A + H +K L + E+ QE S E
Sbjct: 521 YKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEM 580
Query: 948 P---------NPSTPSKAAKF 959
P NP P++ KF
Sbjct: 581 PRQNSDPTSENPPLPTRIEKF 601
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 58.2 bits (139), Expect = 4e-08
Identities = 96/441 (21%), Positives = 184/441 (41%), Gaps = 64/441 (14%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 KHEKER-EQMQRYNQRMIE----QLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGG 830
+ E+ R E Q Y +R +E QL++ QQQ LH
Sbjct: 434 EEERRRAEHEQEYIRRQLEEEQRQLEILQQQ----------------------LLH---- 467
Query: 831 GSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890
EQ ++ +Q E+++++ERLQ+Q K E RD L + E + ++ + +
Sbjct: 468 ----EQALLLEYKRKQLEEQRQAERLQRQLKQE---RDYLVSLQHQRQEQRPVEKKPLYH 520
Query: 891 LVEHETQKLK---ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAEC 947
E + K A + H +K L + E+ QE S E
Sbjct: 521 YKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEM 580
Query: 948 P---------NPSTPSKAAKF 959
P NP P++ KF
Sbjct: 581 PRQNSDPTSENPPLPTRIEKF 601
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 60.1 bits (144), Expect = 1e-08
Identities = 91/435 (20%), Positives = 187/435 (42%), Gaps = 26/435 (5%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 K-------HEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHIN 828
+ HE+E ++ Q QR E+L+ + +QE+ L +Q + R K H
Sbjct: 434 EEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYK 493
Query: 829 GGGSAAEQREKIKQFSQQEE-KRQKSERLQQQQKHENQMRDMLAQCES-NMSELQQLQNE 886
G S +E+ K+ ++ RQ S + + + ++ + ES ++S +Q +
Sbjct: 494 EGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTP 553
Query: 887 KCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRK--KALEEDLNQKKREQEMFFKLSEE 944
V+ + L A+ +P K +E LN EM + + +
Sbjct: 554 PMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEM-PRQNSD 612
Query: 945 AECPNPSTPSKAAKF 959
NP P++ KF
Sbjct: 613 PTSENPPLPTRIEKF 627
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 60.1 bits (144), Expect = 1e-08
Identities = 91/435 (20%), Positives = 187/435 (42%), Gaps = 26/435 (5%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQ---KEDLELAMKRLTT 715
K E + E ++ + +S + + + L RDF+ Q KE E ++
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 716 DNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLR 775
+RE + +R+ L ++Q+ + +++ +EE Q +E+ +L KQQ ++Q ++ R
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQMRR 433
Query: 776 K-------HEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHIN 828
+ HE+E ++ Q QR E+L+ + +QE+ L +Q + R K H
Sbjct: 434 EEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYK 493
Query: 829 GGGSAAEQREKIKQFSQQEE-KRQKSERLQQQQKHENQMRDMLAQCES-NMSELQQLQNE 886
G S +E+ K+ ++ RQ S + + + ++ + ES ++S +Q +
Sbjct: 494 EGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTP 553
Query: 887 KCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRK--KALEEDLNQKKREQEMFFKLSEE 944
V+ + L A+ +P K +E LN EM + + +
Sbjct: 554 PMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEM-PRQNSD 612
Query: 945 AECPNPSTPSKAAKF 959
NP P++ KF
Sbjct: 613 PTSENPPLPTRIEKF 627
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 60.1 bits (144), Expect = 1e-08
Identities = 51/209 (24%), Positives = 99/209 (47%), Gaps = 29/209 (13%)
Query: 556 EEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELEN 615
E LRRQ+L E + + EEH+ Q L + KR E++ +++ + +
Sbjct: 363 ERSEALRRQQL-EQQQRENEEHKRQL---------LAERQKRIEEQKEQRRRLEEQQRRE 412
Query: 616 LE-RQQKQQVEKMEQDHAVRRREEARRIRLEQD---RDYTRFQEQLKLMKKEVKNEVEKL 671
E R+Q+++ ++ + +RR EE RR EQ+ R Q QL+++++++ +E L
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 672 PRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMK 731
+RK+ +Q+ E Q++ +RD++ + R+E E++ L
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQH------------QRQEQRPVEKKPLYH 520
Query: 732 KQELLRDREAALWEMEEHQLQERHQLVKQ 760
+E + E W E ++ER +L +Q
Sbjct: 521 YKEGMSPSEKPAWAKE---VEERSRLNRQ 546
Score = 58.2 bits (139), Expect = 4e-08
Identities = 76/348 (21%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNR 718
K E + E ++ + +S + + + L RDF+ Q + E R R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE----RSEALRR 370
Query: 719 REICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHE 778
+++ ++RE K++LL +R+ + E Q ++R +L +QQ +R + LRK +
Sbjct: 371 QQLEQQQRENEEHKRQLLAERQKRI----EEQKEQRRRLEEQQ-------RREKELRK-Q 418
Query: 779 KEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQRE 838
+EREQ + Y ++M + + R+ + + + Q E + ++ + ++ L EQ
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL-------LHEQAL 471
Query: 839 KIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNE 886
++ +Q E+++++ERLQ+Q K E RD L + E + ++ +
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQE---RDYLVSLQHQRQEQRPVEKK 516
Score = 57.4 bits (137), Expect = 6e-08
Identities = 56/273 (20%), Positives = 127/273 (46%), Gaps = 43/273 (15%)
Query: 560 FLRRQELRELRLLQKEEH--RNQTQLSNKHELQLEQMHKRFEQEIN-------------- 603
F+R Q +Q ++H R + + K E + E E+E N
Sbjct: 288 FIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE 347
Query: 604 --AKKKFFDTELENLERQQ---KQQVEKMEQDHAVRRRE--EARRIRLEQDRDYTRFQEQ 656
++ F +L N ER + +QQ+E+ ++++ +R+ R+ R+E+ ++ R E+
Sbjct: 348 STLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEE 407
Query: 657 LKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTD 716
+ +KE++ + E R+QR+ +Q E +++ +++++ +Q E+ + ++ L
Sbjct: 408 QQRREKELRKQQE---REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEIL--- 461
Query: 717 NRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRK 776
++ L+ +Q LL + + ++EE + ER Q +Q +D +H+ +
Sbjct: 462 ---------QQQLLHEQALLLEYKRK--QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
Query: 777 HEKEREQMQRYNQRMIEQLK---VRQQQEKARL 806
E++ + Y + M K ++ +E++RL
Sbjct: 511 RPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRL 543
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 20/169 (11%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKH---ELQLEQMHKRFEQEI 602
++++E +K+ EE + RR+ L E + +KE + Q + +H +++ E+ +R E E
Sbjct: 386 QLLAERQKRIEEQKEQRRR-LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQ 444
Query: 603 NAKKKFFDTELENLERQQKQQVE--------KMEQDHAVRRREEARRIRLEQDRDY-TRF 653
++ + E LE Q+Q + K +Q R+ E +R +L+Q+RDY
Sbjct: 445 EYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQR-QLKQERDYLVSL 503
Query: 654 QEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQ 702
Q Q ++ + VEK P KE M E+ K++ +R + +Q
Sbjct: 504 QHQ-----RQEQRPVEKKPLYHYKEGMSPS-EKPAWAKEVEERSRLNRQ 546
Score = 39.3 bits (90), Expect = 0.018
Identities = 48/264 (18%), Positives = 114/264 (43%), Gaps = 45/264 (17%)
Query: 684 MEEHTQK---KQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDRE 740
++ H+Q+ +QL+ F+ Q + ++ ++ ++ D+ ++ +K E +
Sbjct: 271 VKNHSQRPATEQLMKHPFIRDQPNERQVRIQL------KDHIDRTKKKRGEKDETEYEYS 324
Query: 741 AALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ 800
+ E EE+ E ++ L + L+R + LR +E+ + ++ +EQ + +
Sbjct: 325 GSEEEEEENDSGEPSSILN--LPGESTLRR-DFLRLQLANKERSEALRRQQLEQQQRENE 381
Query: 801 QEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQ 860
+ K +L AE++++I EE++++ RL++QQ
Sbjct: 382 EHKRQL--------------------------LAERQKRI------EEQKEQRRRLEEQQ 409
Query: 861 KHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPR 920
+ E ++R + E +Q++ E+ EHE + ++ E + L+ + +L
Sbjct: 410 RREKELRKQ-QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHE 468
Query: 921 KKALEEDLNQKKREQEMFFKLSEE 944
+ L E ++ EQ +L +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQ 492
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 227 bits (578), Expect = 5e-59
Identities = 126/325 (38%), Positives = 193/325 (59%), Gaps = 20/325 (6%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYYH------DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ D +LW+++EFC G+V D I L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L+ LH ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YD+K+D+WSLGIT IEMA+ PP +++PMR L I ++ P L + K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAE----------AKA 312
WS +F+ F++ L KN RP+ QL++HPF+ + + +R + + K
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 313 EVMEEIEDGRDEGEEEDAVDAASTL 337
E E +E EE D+ + +S L
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSIL 342
Score = 60.1 bits (144), Expect = 1e-08
Identities = 51/209 (24%), Positives = 99/209 (47%), Gaps = 29/209 (13%)
Query: 556 EEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELEN 615
E LRRQ+L E + + EEH+ Q L + KR E++ +++ + +
Sbjct: 363 ERSEALRRQQL-EQQQRENEEHKRQL---------LAERQKRIEEQKEQRRRLEEQQRRE 412
Query: 616 LE-RQQKQQVEKMEQDHAVRRREEARRIRLEQD---RDYTRFQEQLKLMKKEVKNEVEKL 671
E R+Q+++ ++ + +RR EE RR EQ+ R Q QL+++++++ +E L
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 672 PRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMK 731
+RK+ +Q+ E Q++ +RD++ + R+E E++ L
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQH------------QRQEQRPVEKKPLYH 520
Query: 732 KQELLRDREAALWEMEEHQLQERHQLVKQ 760
+E + E W E ++ER +L +Q
Sbjct: 521 YKEGMSPSEKPAWAKE---VEERSRLNRQ 546
Score = 58.2 bits (139), Expect = 4e-08
Identities = 76/348 (21%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQ-LEQMHKRFEQEINA 604
++I+ DE D F + +L L + E L + H ++ L + + + +
Sbjct: 198 EVIACDENPDATYDF--KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 605 KK--KFFDTELENL---ERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKL 659
KK K F + +E+ Q+ E++ + +R + R++R+ Q +D+ ++ +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRTKKKRG 314
Query: 660 MKKEVKNEVEKLPRQQRK-ESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNR 718
K E + E ++ + +S + + + L RDF+ Q + E R R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE----RSEALRR 370
Query: 719 REICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHE 778
+++ ++RE K++LL +R+ + E Q ++R +L +QQ +R + LRK +
Sbjct: 371 QQLEQQQRENEEHKRQLLAERQKRI----EEQKEQRRRLEEQQ-------RREKELRK-Q 418
Query: 779 KEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQRE 838
+EREQ + Y ++M + + R+ + + + Q E + ++ + ++ L EQ
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL-------LHEQAL 471
Query: 839 KIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNE 886
++ +Q E+++++ERLQ+Q K E RD L + E + ++ +
Sbjct: 472 LLEYKRKQLEEQRQAERLQRQLKQE---RDYLVSLQHQRQEQRPVEKK 516
Score = 57.4 bits (137), Expect = 6e-08
Identities = 56/273 (20%), Positives = 127/273 (46%), Gaps = 43/273 (15%)
Query: 560 FLRRQELRELRLLQKEEH--RNQTQLSNKHELQLEQMHKRFEQEIN-------------- 603
F+R Q +Q ++H R + + K E + E E+E N
Sbjct: 288 FIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE 347
Query: 604 --AKKKFFDTELENLERQQ---KQQVEKMEQDHAVRRRE--EARRIRLEQDRDYTRFQEQ 656
++ F +L N ER + +QQ+E+ ++++ +R+ R+ R+E+ ++ R E+
Sbjct: 348 STLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEE 407
Query: 657 LKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTD 716
+ +KE++ + E R+QR+ +Q E +++ +++++ +Q E+ + ++ L
Sbjct: 408 QQRREKELRKQQE---REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEIL--- 461
Query: 717 NRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRK 776
++ L+ +Q LL + + ++EE + ER Q +Q +D +H+ +
Sbjct: 462 ---------QQQLLHEQALLLEYKRK--QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
Query: 777 HEKEREQMQRYNQRMIEQLK---VRQQQEKARL 806
E++ + Y + M K ++ +E++RL
Sbjct: 511 RPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRL 543
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 20/169 (11%)
Query: 546 KIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKH---ELQLEQMHKRFEQEI 602
++++E +K+ EE + RR+ L E + +KE + Q + +H +++ E+ +R E E
Sbjct: 386 QLLAERQKRIEEQKEQRRR-LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQ 444
Query: 603 NAKKKFFDTELENLERQQKQQVE--------KMEQDHAVRRREEARRIRLEQDRDY-TRF 653
++ + E LE Q+Q + K +Q R+ E +R +L+Q+RDY
Sbjct: 445 EYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQR-QLKQERDYLVSL 503
Query: 654 QEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQ 702
Q Q ++ + VEK P KE M E+ K++ +R + +Q
Sbjct: 504 QHQ-----RQEQRPVEKKPLYHYKEGMSPS-EKPAWAKEVEERSRLNRQ 546
Score = 39.3 bits (90), Expect = 0.018
Identities = 48/264 (18%), Positives = 114/264 (43%), Gaps = 45/264 (17%)
Query: 684 MEEHTQK---KQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDRE 740
++ H+Q+ +QL+ F+ Q + ++ ++ ++ D+ ++ +K E +
Sbjct: 271 VKNHSQRPATEQLMKHPFIRDQPNERQVRIQL------KDHIDRTKKKRGEKDETEYEYS 324
Query: 741 AALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ 800
+ E EE+ E ++ L + L+R + LR +E+ + ++ +EQ + +
Sbjct: 325 GSEEEEEENDSGEPSSILN--LPGESTLRR-DFLRLQLANKERSEALRRQQLEQQQRENE 381
Query: 801 QEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQ 860
+ K +L AE++++I EE++++ RL++QQ
Sbjct: 382 EHKRQL--------------------------LAERQKRI------EEQKEQRRRLEEQQ 409
Query: 861 KHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPR 920
+ E ++R + E +Q++ E+ EHE + ++ E + L+ + +L
Sbjct: 410 RREKELRKQ-QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHE 468
Query: 921 KKALEEDLNQKKREQEMFFKLSEE 944
+ L E ++ EQ +L +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQ 492
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 226 bits (577), Expect = 6e-59
Identities = 132/355 (37%), Positives = 203/355 (57%), Gaps = 18/355 (5%)
Query: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
DP ++E+V +G+G +G+VYK ++ +TG LAA KV++ +EE E+ EI +L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
Query: 91 PY-IVKLLGAYY------HDGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQML 142
I GA+ +D +LW+++EFC G+V D + L E I +CR++L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 143 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
L LH+ ++IHRD+K NVL+T +++L DFGVSA+ +T+ +R++FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 203 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 262
V+ C+ D YDY++DIWSLGIT IEMA+ PP +++PMR L I ++ PP L + K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KK 257
Query: 263 WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGR 322
WS +F DF+ L K +RP QLL+ PF+ + + +R ++ + I+ R
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVR-------IQLKDHIDRSR 310
Query: 323 DE-GEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVN 376
+ GE+E+ S E + E PS + P E + Q ++ N
Sbjct: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSN 365
Score = 50.8 bits (120), Expect = 6e-06
Identities = 62/256 (24%), Positives = 117/256 (45%), Gaps = 33/256 (12%)
Query: 614 ENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDR---------DYTRFQEQLKLMKKEV 664
++++R +K++ EK E ++ EE E+ + T +E L+L ++E
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRL-QQEN 362
Query: 665 KNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDF-VAKQKEDLELAMKRLTTDNRREICD 723
K+ E L +QQ+ + +Q+ E K L R + +QKE+ +R+ RRE
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEE----RRRVEEQQRRE--- 415
Query: 724 KERECLMKK--QELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKER 781
+E+ L +K Q L D +A E E Q + + ++QL++Q R+ E+ +
Sbjct: 416 REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ---------RQSERLQ 466
Query: 782 EQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGS---AAEQRE 838
Q+Q+ ++ L+ +QQQ++ + + Q+ R +Y +N A E E
Sbjct: 467 RQLQQ-EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEE 525
Query: 839 KIKQFSQQEEKRQKSE 854
+ + QQ KS+
Sbjct: 526 RTRMNKQQNSPLAKSK 541
Score = 50.1 bits (118), Expect = 1e-05
Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 25/156 (16%)
Query: 561 LRRQELRELRLLQKEEHRNQTQLSNKHELQ--------------LEQMHKRFEQEINAKK 606
LRR+ LR LQ+E N L + +LQ L Q +R E++ ++
Sbjct: 351 LRREFLR----LQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 607 KFFDT---ELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQD--RDYTRFQEQLKLMK 661
+ + E E + Q+K+Q ++E A+RR EE R+ EQ+ R Q Q + ++
Sbjct: 407 RVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQ 466
Query: 662 KEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRD 697
++++ E L Q+++ +Q ++ Q++QLL D
Sbjct: 467 RQLQQEHAYLKSLQQQQQQQQLQKQ--QQQQLLPGD 500
Score = 48.9 bits (115), Expect = 2e-05
Identities = 59/266 (22%), Positives = 113/266 (42%), Gaps = 50/266 (18%)
Query: 552 EKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDT 611
EK++ E + +E + + H + + S+ + E +R + + K
Sbjct: 315 EKEETEYEYSGSEE-------EDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSE 367
Query: 612 ELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKL 671
L+ ++ Q+QQ E + RRI +E K E ++
Sbjct: 368 ALKQQQQLQQQQQRDPEAHIKHLLHQRQRRI-------------------EEQKEERRRV 408
Query: 672 PRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMK 731
QQR+E ++K++E Q+++L D + +++E RR+ ERE K
Sbjct: 409 EEQQRREREQRKLQEKEQQRRLEDMQALRREEE-------------RRQ---AEREQEYK 452
Query: 732 KQELLRDREAALWEMEEHQLQERHQLVK--QQLKDQYFLQRHELLRKHEKEREQMQRYNQ 789
+++L R++ E + QLQ+ H +K QQ + Q LQ+ + + +R+ + Y +
Sbjct: 453 RKQLEEQRQS---ERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGR 509
Query: 790 RMIEQLK---VRQQQEKARLPKIQRS 812
M K R+ +E+ R+ K Q S
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNS 535
Score = 47.0 bits (110), Expect = 9e-05
Identities = 36/147 (24%), Positives = 72/147 (48%), Gaps = 15/147 (10%)
Query: 550 EDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFF 609
+ E K ++Q+L++ + E H KH L Q +R E++ +++
Sbjct: 359 QQENKSNSEALKQQQQLQQQQQRDPEAH-------IKH--LLHQRQRRIEEQKEERRRV- 408
Query: 610 DTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVE 669
E + ER+Q++ EK +Q RR E+ + +R E++R +++ K + E + + E
Sbjct: 409 -EEQQRREREQRKLQEKEQQ----RRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSE 463
Query: 670 KLPRQQRKESMKQKMEEHTQKKQLLDR 696
+L RQ ++E K + Q++Q L +
Sbjct: 464 RLQRQLQQEHAYLKSLQQQQQQQQLQK 490
Score = 45.4 bits (106), Expect = 3e-04
Identities = 48/210 (22%), Positives = 91/210 (43%), Gaps = 20/210 (9%)
Query: 750 QLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKI 809
+LQ+ ++ + LK Q LQ+ + R E + + QR IE+ Q++E+ R+ +
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQ 411
Query: 810 QRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEE-KRQKSERLQQQQKHENQMRD 868
QR E + R K+ A + E+ +Q +++E KR++ E +Q ++ + Q++
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQ 471
Query: 869 MLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKK-----A 923
A +S + QQ Q +K Q+ + L + L + + P K
Sbjct: 472 EHAYLKSLQQQQQQQQLQK---------QQQQQLLPGDRKPLYHYGRGMNPADKPAWARE 522
Query: 924 LEEDLNQKKREQEMFFKLSEEAECPNPSTP 953
+EE K++ K + P P P
Sbjct: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPIP 552
Score = 34.7 bits (78), Expect = 0.44
Identities = 23/80 (28%), Positives = 46/80 (57%), Gaps = 11/80 (13%)
Query: 550 EDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFF 609
E +++ E+M+ LRR+E E R ++E+ + QL + + Q E++ ++ +QE K
Sbjct: 425 EQQRRLEDMQALRREE--ERRQAEREQEYKRKQL--EEQRQSERLQRQLQQEHAYLKSL- 479
Query: 610 DTELENLERQQKQQVEKMEQ 629
++QQ+QQ++K +Q
Sbjct: 480 ------QQQQQQQQLQKQQQ 493
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,331,653
Number of Sequences: 37866
Number of extensions: 1842889
Number of successful extensions: 30513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1021
Number of HSP's successfully gapped in prelim test: 1517
Number of HSP's that attempted gapping in prelim test: 10633
Number of HSP's gapped (non-prelim): 8938
length of query: 968
length of database: 18,247,518
effective HSP length: 112
effective length of query: 856
effective length of database: 14,006,526
effective search space: 11989586256
effective search space used: 11989586256
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.