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Search of human proteins with 126012497
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo
sapiens]
(4490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens] 8957 0.0
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens] 5675 0.0
gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens] 2323 0.0
gi|75677365 dynein heavy chain domain 3 [Homo sapiens] 2086 0.0
gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens] 2031 0.0
gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens] 1964 0.0
gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sap... 1930 0.0
gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 1926 0.0
gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens] 1900 0.0
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 1896 0.0
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 1895 0.0
gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens] 1825 0.0
gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens] 1821 0.0
gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens] 1299 0.0
gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens] 1125 0.0
gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens] 924 0.0
gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [H... 760 0.0
gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo sap... 444 e-124
gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens] 162 7e-39
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 49 1e-04
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 49 1e-04
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 44 0.004
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 44 0.005
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens] 44 0.005
gi|38044112 restin isoform b [Homo sapiens] 41 0.031
gi|4506751 restin isoform a [Homo sapiens] 41 0.031
gi|83716024 kinesin family member 21B [Homo sapiens] 41 0.031
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 40 0.040
gi|58530840 desmoplakin isoform I [Homo sapiens] 40 0.052
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 40 0.052
>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
Length = 4490
Score = 8957 bits (23241), Expect = 0.0
Identities = 4490/4490 (100%), Positives = 4490/4490 (100%)
Query: 1 MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN 60
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
Sbjct: 1 MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN 60
Query: 61 IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF 120
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
Sbjct: 61 IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF 120
Query: 121 SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK 180
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
Sbjct: 121 SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK 180
Query: 181 RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL 240
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
Sbjct: 181 RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL 240
Query: 241 EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY 300
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
Sbjct: 241 EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY 300
Query: 301 ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG 360
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
Sbjct: 301 ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG 360
Query: 361 KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT 420
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
Sbjct: 361 KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT 420
Query: 421 EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI 480
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
Sbjct: 421 EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI 480
Query: 481 ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD 540
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
Sbjct: 481 ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD 540
Query: 541 ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN 600
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
Sbjct: 541 ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN 600
Query: 601 FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV 660
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
Sbjct: 601 FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV 660
Query: 661 FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID 720
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
Sbjct: 661 FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID 720
Query: 721 TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ 780
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
Sbjct: 721 TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ 780
Query: 781 IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA 840
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
Sbjct: 781 IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA 840
Query: 841 FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL 900
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
Sbjct: 841 FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL 900
Query: 901 DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF 960
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
Sbjct: 901 DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF 960
Query: 961 EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV 1020
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
Sbjct: 961 EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV 1020
Query: 1021 KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK 1080
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
Sbjct: 1021 KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK 1080
Query: 1081 MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL 1140
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
Sbjct: 1081 MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL 1140
Query: 1141 GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES 1200
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
Sbjct: 1141 GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES 1200
Query: 1201 VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL 1260
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
Sbjct: 1201 VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL 1260
Query: 1261 PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR 1320
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
Sbjct: 1261 PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR 1320
Query: 1321 KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF 1380
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
Sbjct: 1321 KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF 1380
Query: 1381 CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK 1440
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
Sbjct: 1381 CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK 1440
Query: 1441 GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY 1500
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
Sbjct: 1441 GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY 1500
Query: 1501 LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE 1560
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
Sbjct: 1501 LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE 1560
Query: 1561 QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF 1620
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
Sbjct: 1561 QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF 1620
Query: 1621 HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS 1680
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
Sbjct: 1621 HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS 1680
Query: 1681 GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT 1740
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
Sbjct: 1681 GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT 1740
Query: 1741 THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS 1800
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
Sbjct: 1741 THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS 1800
Query: 1801 ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG 1860
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
Sbjct: 1801 ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG 1860
Query: 1861 RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT 1920
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
Sbjct: 1861 RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT 1920
Query: 1921 ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII 1980
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
Sbjct: 1921 ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII 1980
Query: 1981 MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE 2040
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
Sbjct: 1981 MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE 2040
Query: 2041 DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG 2100
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
Sbjct: 2041 DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG 2100
Query: 2101 LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK 2160
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
Sbjct: 2101 LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK 2160
Query: 2161 AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD 2220
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
Sbjct: 2161 AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD 2220
Query: 2221 DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK 2280
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
Sbjct: 2221 DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK 2280
Query: 2281 KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV 2340
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
Sbjct: 2281 KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV 2340
Query: 2341 SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT 2400
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
Sbjct: 2341 SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT 2400
Query: 2401 DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT 2460
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
Sbjct: 2401 DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT 2460
Query: 2461 AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV 2520
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
Sbjct: 2461 AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV 2520
Query: 2521 FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN 2580
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
Sbjct: 2521 FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN 2580
Query: 2581 DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW 2640
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
Sbjct: 2581 DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW 2640
Query: 2641 QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF 2700
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
Sbjct: 2641 QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF 2700
Query: 2701 ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI 2760
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
Sbjct: 2701 ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI 2760
Query: 2761 YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG 2820
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
Sbjct: 2761 YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG 2820
Query: 2821 VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS 2880
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
Sbjct: 2821 VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS 2880
Query: 2881 EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS 2940
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
Sbjct: 2881 EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS 2940
Query: 2941 RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV 3000
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
Sbjct: 2941 RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV 3000
Query: 3001 CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI 3060
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
Sbjct: 3001 CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI 3060
Query: 3061 NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK 3120
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
Sbjct: 3061 NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK 3120
Query: 3121 NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP 3180
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
Sbjct: 3121 NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP 3180
Query: 3181 HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE 3240
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
Sbjct: 3181 HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE 3240
Query: 3241 ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR 3300
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
Sbjct: 3241 ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR 3300
Query: 3301 LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL 3360
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
Sbjct: 3301 LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL 3360
Query: 3361 SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI 3420
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
Sbjct: 3361 SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI 3420
Query: 3421 PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK 3480
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
Sbjct: 3421 PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK 3480
Query: 3481 SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF 3540
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
Sbjct: 3481 SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF 3540
Query: 3541 KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE 3600
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
Sbjct: 3541 KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE 3600
Query: 3601 KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV 3660
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
Sbjct: 3601 KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV 3660
Query: 3661 SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM 3720
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
Sbjct: 3661 SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM 3720
Query: 3721 ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF 3780
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
Sbjct: 3721 ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF 3780
Query: 3781 QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK 3840
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
Sbjct: 3781 QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK 3840
Query: 3841 DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT 3900
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
Sbjct: 3841 DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT 3900
Query: 3901 WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG 3960
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
Sbjct: 3901 WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG 3960
Query: 3961 WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ 4020
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
Sbjct: 3961 WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ 4020
Query: 4021 GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA 4080
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
Sbjct: 4021 GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA 4080
Query: 4081 DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK 4140
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
Sbjct: 4081 DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK 4140
Query: 4141 MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET 4200
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
Sbjct: 4141 MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET 4200
Query: 4201 ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ 4260
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
Sbjct: 4201 ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ 4260
Query: 4261 EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG 4320
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
Sbjct: 4261 EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG 4320
Query: 4321 FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN 4380
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
Sbjct: 4321 FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN 4380
Query: 4381 EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST 4440
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
Sbjct: 4381 EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST 4440
Query: 4441 APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK 4490
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK
Sbjct: 4441 APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK 4490
>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
Length = 4624
Score = 5675 bits (14723), Expect = 0.0
Identities = 2804/4521 (62%), Positives = 3492/4521 (77%), Gaps = 41/4521 (0%)
Query: 3 KLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKG-LLNGIRDMLANI 61
K+++ L G+C+FF+R AI I +E F +LDA+ G LLN +R +L++I
Sbjct: 112 KVFVTEGNDVALTGVCVFFIRTDPSKAITPDNIHQEVSFNMLDAADGGLLNSVRRLLSDI 171
Query: 62 FLPAVLATNN-WGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF 120
F+PA+ AT++ WG L + + + F ++ +++ L GA+ S++ V L+ D +
Sbjct: 172 FIPALRATSHGWGELEGLQDAANIRQEFLSSLEGFVNVLSGAQESLKEKVNLRKCDILEL 231
Query: 121 SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK 180
L + A+N ET+ ++E+ + VW KQ EQVL E+ Q+ KEA D GP ELEHWK
Sbjct: 232 KTLKEPTDYLTLANNPETLGKIEDCMKVWIKQTEQVLAENNQLLKEADDVGPRAELEHWK 291
Query: 181 RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL 240
+ +KFNY++EQ+K P KAV+ VL A SKLLK WR++D RITD NE+KDNV+YLYTL
Sbjct: 292 KRLSKFNYLLEQLKSPDVKAVLAVLAAAKSKLLKTWREMDIRITDATNEAKDNVKYLYTL 351
Query: 241 EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY 300
EK C PLY+ D +SM I LINAI+MI+ +S YYNTSE++TSLF+KVTNQ+++ACKAY
Sbjct: 352 EKCCDPLYSSDPLSMMDAIPTLINAIKMIYSISHYYNTSEKITSLFVKVTNQIISACKAY 411
Query: 301 ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG 360
IT+ G +W+Q VV +KI I L +EYQ FHKT++ + ++ K F+ SEMYIFG
Sbjct: 412 ITNNGTASIWNQPQDVVEEKILSAIKLKQEYQLCFHKTKQKLKQNPNAKQFDFSEMYIFG 471
Query: 361 KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT 420
KFE F +RL KI ++ T ++TYS L +STIEG++ MA K++ I +KKK+Y+ LD R+
Sbjct: 472 KFETFHRRLAKIIDIFTTLKTYSVLQDSTIEGLEDMATKYQGIVATIKKKEYNFLDQRKM 531
Query: 421 EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI 480
+FD D+ +F + N L +++ FM+ +F KI ++ QAL++L++F++LNIP LG++ + +
Sbjct: 532 DFDQDYEEFCKQTNDLHNELRKFMDVTFAKIQNTNQALRMLKKFERLNIPNLGIDDKYQL 591
Query: 481 ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD 540
IL+ Y A++D KLY QK DPPLARN PPIAGKILW RQL+ RI +P+ F ++
Sbjct: 592 --ILENYGADIDMISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRIQQPMQLFQQHPA 649
Query: 541 ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN 600
+LS+ + K +IR YN+++ VL+EFEV++H AW+R+I ++H L+A+L V+ P TG+L VN
Sbjct: 650 VLSTAEAKPIIRSYNRMAKVLLEFEVLFHRAWLRQIEEIHVGLEASLLVKAPGTGELFVN 709
Query: 601 FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV 660
FDP+IL + RET+CM +M L+V A L + + K + ++ +L Y + ++P+
Sbjct: 710 FDPQILILFRETECMAQMGLEVSPLATSLFQKRDRYKRNFSNMKMMLAEYQRVKSKIPAA 769
Query: 661 FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID 720
L+ P + KV+ L+ GL LTW+SL +E++ + + LL +++DL E ID
Sbjct: 770 IEQLIVPHLAKVDEALQPGLAALTWTSLNIEAYLENTFAKIKDLELLLDRVNDLIEFRID 829
Query: 721 TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIF-- 778
+L+E++ T L LP+ E+ L + + A IL+ KS VEEAV EL+++
Sbjct: 830 AILEEMSSTPLCQLPQEEPLTCEEFLQMTKDLCVNGAQILHFKSSLVEEAVNELVNMLLD 889
Query: 779 ---------EQIYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKED 829
E+I + S +R+ F + T N A ++ KE
Sbjct: 890 VEVLSEEESEKISNENSVNYKNESSAKREEGNFDTLTSS-INARANALLLTTVTRKKKET 948
Query: 830 EFK-KECKEVFAFFSHQLLDSLQKATRLSLDTMKRRI-------FVASLYGRKQSEDIIS 881
E +E +E+ + F+HQ +D+L K TR +L+ +++RI F S ++ +
Sbjct: 949 EMLGEEARELLSHFNHQNMDALLKVTRNTLEAIRKRIHSSHTINFRDSNSASNMKQNSLP 1008
Query: 882 FIKSEVHLAIPNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTT 941
++ V LAIPN+VM P+L+D+QQ +N+ ++ + V +GV W + + K +
Sbjct: 1009 IFRASVTLAIPNIVMAPALEDVQQTLNKAVECIISVPKGVRQWSSELLSK-KKIQERKMA 1067
Query: 942 TDVTHQNTGKLLKKEERSFEEAIPARKL--------KNFYPGVAEHKDISKLVLLLSSSV 993
+++++ ++ E ++ + + KN+Y V+E+K+I KLV +LS+ +
Sbjct: 1068 ALQSNEDSDSDVEMGENELQDTLEIASVNLPIPVQTKNYYKNVSENKEIVKLVSVLSTII 1127
Query: 994 NSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILHYATFEQEIDELK 1053
NS +K ++ F++Y +W + ++ +K F+ +P L+E S+IL++ EQEI+
Sbjct: 1128 NSTKKEVITSMDCFKRYNHIWQKGKEEAIKTFITQSPLLSEFESQILYFQNLEQEINAEP 1187
Query: 1054 PIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPI 1113
+ VG++ L+T +K AL+ E KAW +++ R+ N++Y+ +M + I E+ KKL+RPI
Sbjct: 1188 EYVCVGSIALYTADLKFALTAETKAWMVVIGRHCNKKYRSEMENIFMLIEEFNKKLNRPI 1247
Query: 1114 RDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYSFN 1173
+DLDD+R AM AL IR+ +I +D +GPIEE+YA+LNR+ + + +EE + VDTL Y++
Sbjct: 1248 KDLDDIRIAMAALKEIREEQISIDFQVGPIEESYALLNRYGLLIAREEIDKVDTLHYAWE 1307
Query: 1174 KLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPPQEASNR 1233
KL ++A VQ LV +QP FK L+ +VEVF +D F Y+L GPM + PQEAS+R
Sbjct: 1308 KLLARAGEVQNKLVSLQPSFKKELISAVEVFLQDCHQFYLDYDLNGPMASGLKPQEASDR 1367
Query: 1234 LQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSIS 1293
L +FQ FD+++RK++TY+ GE+LFGLP T Y L + +K+LNLLQK+Y LY++V+ +++
Sbjct: 1368 LIMFQNQFDNIYRKYITYTGGEELFGLPATQYPQLLEIKKQLNLLQKIYTLYNSVIETVN 1427
Query: 1294 GYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMT 1353
YY+ILW +V+IEKIN ELLEFQNRCRKLP+ LKDWQAFLDLKK IDDFSE CPLLE M
Sbjct: 1428 SYYDILWSEVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKIIDDFSECCPLLEYMA 1487
Query: 1354 NKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAK 1413
+KAM +RHW+RI+ LTG DV ++SF LRNIMEAPLLK+K++IEDICISA+KE+DIE K
Sbjct: 1488 SKAMMERHWERITTLTGHSLDVGNESFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQK 1547
Query: 1414 LTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKN 1473
L QVI W N+ +F +FK +GELLL+G + EII MEDSLM+LGSLLSNRYN PFK
Sbjct: 1548 LKQVINEWDNKTFTFGSFKTRGELLLRGDSTSEIIANMEDSLMLLGSLLSNRYNMPFKAQ 1607
Query: 1474 IQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQ 1533
IQ WV LS S+DIIE W+ VQNLW+YLEAVFVGGDIAKQLP+EAKRF NIDKSW+KIM
Sbjct: 1608 IQKWVQYLSNSTDIIESWMTVQNLWIYLEAVFVGGDIAKQLPKEAKRFSNIDKSWVKIMT 1667
Query: 1534 RAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLE 1593
RAHE P+V+ CCVGDET+GQLLPHL +QLE+CQKSLTGYLEKKRL FPRFFFVSDP LLE
Sbjct: 1668 RAHEVPSVVQCCVGDETLGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLE 1727
Query: 1594 ILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDRIMAVISREGEKIVLDNSVMAKGPVEI 1653
ILGQASDSHTIQ HL V DNI V FH K YDRI+++ S+EGE I LD VMA+G VE+
Sbjct: 1728 ILGQASDSHTIQAHLLNVFDNIKSVKFHEKIYDRILSISSQEGETIELDKPVMAEGNVEV 1787
Query: 1654 WLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALR 1713
WL LL+ SSLH +IR A I ++GFQL FLS FPAQVGLLGIQM+WT DSEEALR
Sbjct: 1788 WLNSLLEESQSSLHLVIRQAAANIQETGFQLTEFLSSFPAQVGLLGIQMIWTRDSEEALR 1847
Query: 1714 NAKDDRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMH 1773
NAK D+KIMQ TNQ FL++LNTLI TT DLS +RVK+ETLITIHVHQRDIFDDL MH
Sbjct: 1848 NAKFDKKIMQKTNQAFLELLNTLIDVTTRDLSSTERVKYETLITIHVHQRDIFDDLCHMH 1907
Query: 1774 IKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLA 1833
IKSP DFEWLKQ RFYF ED D+ ++ ITDV FIYQNEFLGCTDRLVITPLTDRCYITLA
Sbjct: 1908 IKSPMDFEWLKQCRFYFNEDSDKMMIHITDVAFIYQNEFLGCTDRLVITPLTDRCYITLA 1967
Query: 1834 QALGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGS 1893
QALGM+MGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGS
Sbjct: 1968 QALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGS 2027
Query: 1894 WGCFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGY 1953
WGCFDEFNRI+LPVLSVAAQQI I+LT +KE KK FIF+DGD V +NPEFG+FLTMNPGY
Sbjct: 2028 WGCFDEFNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGY 2087
Query: 1954 AGRQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTK 2013
AGRQELPENLKI FR+VAMMVPDRQII+RVKLASCGF++NV+LA+KF+ LYKLCEEQL+K
Sbjct: 2088 AGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCGFIDNVVLARKFFTLYKLCEEQLSK 2147
Query: 2014 QVHYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLIND 2073
QVHYDFGLRNILSVLRTLG+ KRA P D+E +IVMR LRDMNLSKL+DEDEPLFLSLI D
Sbjct: 2148 QVHYDFGLRNILSVLRTLGAAKRANPMDTESTIVMRVLRDMNLSKLIDEDEPLFLSLIED 2207
Query: 2074 LFPGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSG 2133
LFP + LD Y EL+ A++ QV+ GLINHPPW LK++QL+ET VRHG+MTLGPSG+G
Sbjct: 2208 LFPNILLDKAGYPELEAAISRQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGAG 2267
Query: 2134 KTTVITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKA 2193
KTT I LM+A T+CG+PHREMRMNPKAITAPQMFGRLD ATNDWTDGIFSTLWRKTL+A
Sbjct: 2268 KTTCIHTLMRAMTDCGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRKTLRA 2327
Query: 2194 KKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASP 2253
KKGE+I++ILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAP+CK++FE HNI+NASP
Sbjct: 2328 KKGEHIWIILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPNCKIIFEPHNIDNASP 2387
Query: 2254 ATVSRMGMVYISSSALSWRPILQAWLKKRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKM 2313
ATVSR GMV++SSS L W PIL+ +LKKR+ QEA + LY + F D Y + NL KM
Sbjct: 2388 ATVSRNGMVFMSSSILDWSPILEGFLKKRSPQEAEILRQLYTESFPDLYRFCIQNLEYKM 2447
Query: 2314 QLLECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLGALLELESREKLEAF 2373
++LE I QS+N+L+GLIP KE+GG HL +LFVF L+WS GA LEL+ R +LE +
Sbjct: 2448 EVLEAFVITQSINMLQGLIPLKEQGGEVSQAHLGRLFVFALLWSAGAALELDGRRRLELW 2507
Query: 2374 LRQHES-KLDLPEIPKGSNQTMYEFYVTDYGDWEHWNKKLQPYYYPTDSIPEYSSILVPN 2432
LR + L+LP P G T +++YV G W HWN + Q Y YP+D+ PEY SILVPN
Sbjct: 2508 LRSRPTGTLELPP-PAGPGDTAFDYYVAPDGTWTHWNTRTQEYLYPSDTTPEYGSILVPN 2566
Query: 2433 VDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPM 2492
VDN+RT+FLI TIAKQ KAVLL GEQGTAKTV++K ++ KYDPE + KSLNFSSAT P+
Sbjct: 2567 VDNVRTDFLIQTIAKQGKAVLLIGEQGTAKTVIIKGFMSKYDPECHMIKSLNFSSATTPL 2626
Query: 2493 MFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMY 2552
MFQRTIESYVDKR+G+TYGPP G+KMTVFIDD+NMP+INEWGDQ+TNEIVRQ+ME G Y
Sbjct: 2627 MFQRTIESYVDKRMGTTYGPPAGKKMTVFIDDVNMPIINEWGDQVTNEIVRQLMEQNGFY 2686
Query: 2553 SLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGC 2612
+L+KPG+FT+IVD+Q +AAMIHPGGGRNDIPQRLKRQF++FNCTLPS AS+DKIFG+IG
Sbjct: 2687 NLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLKRQFSIFNCTLPSEASVDKIFGVIGV 2746
Query: 2613 GYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLT 2672
G++ R F ++ + + LV + R LWQ TK+KMLPTP+KFHY+FNLRDLSR+WQGML
Sbjct: 2747 GHYCTQRGFSEEVRDSVTKLVPLTRRLWQMTKIKMLPTPAKFHYVFNLRDLSRVWQGMLN 2806
Query: 2673 IKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSD---AASCI 2729
+E LL L+KHEC RVIADRF D WF+ L VEE G + C
Sbjct: 2807 TTSEVIKEPNDLLKLWKHECKRVIADRFTVSSDVTWFDKALVSLVEEEFGEEKKLLVDCG 2866
Query: 2730 LPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTS 2789
+ + YFVDFLR+ PE G+ E++ E PKIYE + SF L E+L + + +NE IRG
Sbjct: 2867 I-DTYFVDFLRDAPEAAGETSEEADAETPKIYEPIESFSHLKERLNMFLQLYNESIRGAG 2925
Query: 2790 LDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRS 2849
+D+VFF DAM HL+KISR+IRT GNALLVGVGGSGKQSL+RLASFIAGY FQITLTRS
Sbjct: 2926 MDMVFFADAMVHLVKISRVIRTPQGNALLVGVGGSGKQSLTRLASFIAGYVSFQITLTRS 2985
Query: 2850 YNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEM 2909
YN +NL +DLK LY+ AG GKGITFIFTD+EIKDE+FLEY+NN+LSSGE+SNLFARDE+
Sbjct: 2986 YNTSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKDESFLEYMNNVLSSGEVSNLFARDEI 3045
Query: 2910 DEITQGLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGL 2969
DEI L SVMK+E PR PT +NL++YF+SR R+NLH+VLCFSPVGEKFR R+LKFP L
Sbjct: 3046 DEINSDLASVMKKEFPRCLPTNENLHDYFMSRVRQNLHIVLCFSPVGEKFRNRALKFPAL 3105
Query: 2970 ISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESYFQ 3029
ISGCT+DWFSRWP++AL+AV+ +FL+ Y+I CS EIK++VV+ MG F D V+E C YFQ
Sbjct: 3106 ISGCTIDWFSRWPKDALVAVSEHFLTSYDIDCSLEIKKEVVQCMGSFQDGVAEKCVDYFQ 3165
Query: 3030 RYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLA 3089
R+RR HVTPKSYLSFI GYK IY EK + A RMN GL+KL EASESVA LS++L
Sbjct: 3166 RFRRSTHVTPKSYLSFIQGYKFIYGEKHVEVRTLANRMNTGLEKLKEASESVAALSKELE 3225
Query: 3090 VKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLE 3149
KEKEL VA+ KAD VL EVT+ AQA+ K+K EVQ+VKD+AQ IVD I +K AE KLE
Sbjct: 3226 AKEKELQVANDKADMVLKEVTMKAQAAEKVKAEVQKVKDRAQAIVDSISKDKAIAEEKLE 3285
Query: 3150 AAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSC 3209
AAKPALEEAEAAL TI+P+DIATVR L +PPHLIMRIMDCVLLLFQ+K+ V +D EKSC
Sbjct: 3286 AAKPALEEAEAALQTIRPSDIATVRTLGRPPHLIMRIMDCVLLLFQRKVSAVKIDLEKSC 3345
Query: 3210 CKPSWGESLKLMSATGFLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGNVAG 3269
PSW ESLKLM+A FL +LQQFPKDTINEE +E L PYF M DY E+AK+VCGNVAG
Sbjct: 3346 TMPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLSPYFEMPDYNIETAKRVCGNVAG 3405
Query: 3270 LLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKF 3329
L SWT AMA F+ IN+EVLPLKANL QE R +A +L KAQA LD+KQAELD VQA++
Sbjct: 3406 LCSWTKAMASFFSINKEVLPLKANLVVQENRHLLAMQDLQKAQAELDDKQAELDVVQAEY 3465
Query: 3330 DAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCT 3389
+ AM EK LL DA+ CR KMQ ASTLI GL+GEK RWT+QS+EF AQ RLVGD+LL T
Sbjct: 3466 EQAMTEKQTLLEDAERCRHKMQTASTLISGLAGEKERWTEQSQEFAAQTKRLVGDVLLAT 3525
Query: 3390 GFLSYLGPFNQIFRNYLLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGLQGLPGD 3449
FLSY GPFNQ FR+ LL D W E++ARKIPF +NLNL ML+D PTI EW LQGLP D
Sbjct: 3526 AFLSYSGPFNQEFRDLLLND-WRKEMKARKIPFGKNLNLSEMLIDAPTISEWNLQGLPND 3584
Query: 3450 DLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLG 3509
DLSIQNGIIVTKA+RYPLLIDPQTQGK WIK+KE N+LQ+TSLNHKYFR HLEDSLSLG
Sbjct: 3585 DLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESRNELQITSLNHKYFRNHLEDSLSLG 3644
Query: 3510 RPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFT 3569
RPLLIED+ EELDPALDNVLE+NFIK+G+TFKVKVGDKE D++D F+LYITTKLPNPA+T
Sbjct: 3645 RPLLIEDVGEELDPALDNVLERNFIKTGSTFKVKVGDKEVDVLDGFRLYITTKLPNPAYT 3704
Query: 3570 PEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNL 3629
PEI+A+TS+IDFTVTMKGLE+QLL RVILTEKQELE ER L+EDVT NKR+MKELEDNL
Sbjct: 3705 PEISARTSIIDFTVTMKGLEDQLLGRVILTEKQELEKERTHLMEDVTANKRRMKELEDNL 3764
Query: 3630 LYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGS 3689
LY+L++T+GSLV+DESLI VL TK+TA EV++KL ++AETE++IN+A+EE+RP ATRGS
Sbjct: 3765 LYRLTSTQGSLVEDESLIVVLSNTKRTAEEVTQKLEISAETEVQINSAREEYRPVATRGS 3824
Query: 3690 ILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSV 3749
ILYFLITEM +VN MYQTSL QFL LFD S+ARS KSP+ KRI NIIE++TYEV+ Y+
Sbjct: 3825 ILYFLITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVYKYAA 3884
Query: 3750 RGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWILDMTWL 3809
RGLYE HKFLF LL+TLKID+QR VKH EF LIKGGA+LDLKACPPKP +WILD+TWL
Sbjct: 3885 RGLYEEHKFLFTLLLTLKIDIQRNRVKHEEFLTLIKGGASLDLKACPPKPSKWILDITWL 3944
Query: 3810 NLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWC 3869
NLVELSKL QF+++++QISRNEK WK WFDK+ PEEE +P+ Y+ SLD +LLLIRSWC
Sbjct: 3945 NLVELSKLRQFSDVLDQISRNEKMWKIWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWC 4004
Query: 3870 PDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQIDALAK 3929
PDRT+ QARKYI DS+ EKY E VIL+LEKTWEESD RTPLIC LSMGSDPT+ I AL K
Sbjct: 4005 PDRTIAQARKYIVDSMGEKYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGK 4064
Query: 3930 KLKLECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFMEELLETLITTEASDD 3989
+LK+E R +SMGQGQEVHARKL+Q +M GGW LLQNCHLGL+FM+EL++ +I TE D
Sbjct: 4065 RLKIETRYVSMGQGQEVHARKLLQQTMANGGWALLQNCHLGLDFMDELMDIIIETELVHD 4124
Query: 3990 SFRVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDISNLPMWKPM 4049
+FR+W+TTE H +FPITLLQ S+KF N+PPQG+RAGLKRT++G++QDLLD+S+ WKPM
Sbjct: 4125 AFRLWMTTEAHKQFPITLLQMSIKFANDPPQGLRAGLKRTYSGVSQDLLDVSSGSQWKPM 4184
Query: 4050 LYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRY 4109
LY VAFLHSTVQERRKFG LGWNIPYEFN ADF+A+VQFIQNHLD+ D+KKGVSW T+RY
Sbjct: 4185 LYAVAFLHSTVQERRKFGALGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTIRY 4244
Query: 4110 MIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTGYKIPLCKTLDQYFEYIQS 4169
MIGE+QYGGRVTDD+DKRLLN FA+VWFSE MF P F FY GY IP C T+D Y +YIQS
Sbjct: 4245 MIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFSFYQGYNIPKCSTVDNYLQYIQS 4304
Query: 4170 LPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGGGVGETREAIVYRLSEDML 4229
LP+ D+PEVFGLHPNADITYQS A VL+TI IQPK++ GG ETREA+V RL++DML
Sbjct: 4305 LPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDTSGGGDETREAVVARLADDML 4364
Query: 4230 SKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIM 4289
KLPPDY+P EVK RL KMG MNIFLRQEIDRMQRV+S++RS+L++LKLAI+GTIIM
Sbjct: 4365 EKLPPDYVPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAIDGTIIM 4424
Query: 4290 SENLRDALDNMYDARIPQLWKRVSWDSSTLGFWFTELLERNAQFSTWIFEGRPNVFWMTG 4349
SENLRDALD M+DARIP WK+ SW SSTLGFWFTEL+ERN+QF++W+F GRP+ FWMTG
Sbjct: 4425 SENLRDALDCMFDARIPAWWKKASWISSTLGFWFTELIERNSQFTSWVFNGRPHCFWMTG 4484
Query: 4350 FFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAA 4409
FFNPQGFLTAMRQE+TRA+KGWALD + + NEV + K++I++PP EGVY+YGLY++GA
Sbjct: 4485 FFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKWMKDDISAPPTEGVYVYGLYLEGAG 4544
Query: 4410 WDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTFITVVYL 4469
WD+RN KL+ES PKVLF +PV+ I+A N+T +DP+ Y CPIYKKP RTDL +I V L
Sbjct: 4545 WDKRNMKLIESKPKVLFELMPVIRIYAENNTL-RDPRFYSCPIYKKPVRTDLNYIAAVDL 4603
Query: 4470 RTVLSPDHWILRGVALLCDIK 4490
RT +P+HW+LRGVALLCD+K
Sbjct: 4604 RTAQTPEHWVLRGVALLCDVK 4624
>gi|198442844 dynein, axonemal, heavy chain 10 [Homo sapiens]
Length = 4471
Score = 2323 bits (6020), Expect = 0.0
Identities = 1450/4563 (31%), Positives = 2407/4563 (52%), Gaps = 292/4563 (6%)
Query: 19 IFFVRCRNDVAINVKTIQEEALFTVLDASK-GLLNG-----IRDMLANIFLPAVLATNNW 72
+FF+R + AI+ T +EA+ + + + G++N +++++ +FLPA+ +
Sbjct: 100 VFFLRNTKE-AISEATDMKEAMEIMPETLEYGIINANVLHFLKNIICQVFLPALSFNQHR 158
Query: 73 ---------GALNQSKQGESE-----------------KHIFTETINRYLSFLDGARISI 106
G ++ S + ES+ + F + ++ S + +
Sbjct: 159 TSTTVGVTSGEVSNSSEHESDLPPMPGEAVEYHSIQLIRDEFLMNVQKFASNIQRTMQQL 218
Query: 107 EGTVKLKTIDNVNFSKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKE 166
EG +KL+ + EV+ A++ ETV LE+ ++ W QI + Q++K
Sbjct: 219 EGEIKLE------MPIISVEGEVSDLAADPETVDILEQCVINWLNQISTAV--EAQLKKT 270
Query: 167 AGDSGPLTELEHWKRMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDT 226
GPL E+E W+ +A + + EQ K P + V++V+ + S L+ N + + +
Sbjct: 271 PQGKGPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQPVFTELFKF 330
Query: 227 ANESKDNVRYLYTLEKVCQPL-YNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSL 285
E+ DNVR+L T+E+ + + + + I +++A+RM+ +SR+YN ERM L
Sbjct: 331 HTEASDNVRFLSTVERYFKNITHGSGFHVVLDTIPAMMSALRMVWIISRHYNKDERMIPL 390
Query: 286 FIKVTNQMVT-ACKAYITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISE 344
++ ++ C+ L ++ + K + + ++ ++ TR I
Sbjct: 391 MERIAWEIAERVCRVV----NLRTLFKENRASAQSKTLEARNTLRLWKKAYFDTRAKIEA 446
Query: 345 SSGEKSFEVSEMYIFGKFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAI--KFRN 402
S E +E +F E+ M T+ Q S D++ I +F N
Sbjct: 447 SGREDRWEFDRKRLF----------ERTDYMATICQDLS----------DVLQILEEFYN 486
Query: 403 IYQGVKKKQYDILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQ 462
I+ K DP+R + D + +++GL ++ F I SSQ ++
Sbjct: 487 IFGPELKAVTG--DPKRID------DVLCRVDGLVTPMENLTFDPFS-IKSSQFWKYVMD 537
Query: 463 RFQKLNIPCLGLEINHTIERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVR 522
F+ IE ++ D K++ ++PPL +N PP+AG I W R
Sbjct: 538 EFK--------------IEVLI-------DIINKIFVQNLENPPLYKNHPPVAGAIYWER 576
Query: 523 QLYRRISEPINYFFKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYA 582
L+ RI I F + +IL S G+ V ++Y ++ + E+E + W+ Q+ A
Sbjct: 577 SLFFRIKHTILRFQEVQEILDSDRGQEVKQKYLEVGRTMKEYEDRKYEQWMEVTEQVLPA 636
Query: 583 L-------QATLFVRHPET----GKLLVNFDPKILEVVRETKCMIKMKLDVPEQAKRLLK 631
L ++++ P T +NF P + E++ ETK + ++ VPE A+ +
Sbjct: 637 LMKKSLLTKSSIATEEPSTLERGAVFAINFSPALREIINETKYLEQLGFTVPELARNVAL 696
Query: 632 LESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSSLTLE 691
E K +Q +L +Y L + L+ +++ V R G L W+SL +
Sbjct: 697 QEDKFLRYTAGIQRMLDHYHMLIGTLNDAESVLLKDHSQELLRVFRSGYKRLNWNSLGIG 756
Query: 692 SFFQEVELVLDMFNQLLKKISDLCEMHIDTVLKEIAKTVLISLPESGATKVEDMLTLNET 751
+ + + F L+ +I + D + + I+L + A K E+ L +
Sbjct: 757 DYITGCKQAIGKFESLVHQI----HKNADDISSRLTLIEAINLFKYPAAKSEEELPGVKE 812
Query: 752 YTKEWADILNHKSKHVEEAVRELISIFEQIYEVKYTGKVGKQSEQRKHVVFGSETGEGEN 811
+ + I ++ V+ VR ++I + +V+ +V + TG+
Sbjct: 813 FFEH---IERERASDVDHMVRWYLAIGPLLTKVE-------------GLVVHTNTGKAPK 856
Query: 812 NDYEANIVNEFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSLDTMKRRIFVASLY 871
+K K+++ + +L +LQ L L
Sbjct: 857 ---------------LASYYKYWEKKIYEVLTKLILKNLQSFNSLILGN----------- 890
Query: 872 GRKQSEDIISFIKSEVHLAIPNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRP 931
+ +E L P +++ P+ ++I + ++ +E+++ W
Sbjct: 891 --------VPLFHTETILTAPEIILHPNTNEIDKMCFHCVRNCVEITKHFVRWMNG---- 938
Query: 932 IKSVIPSPTTTDVTHQNTGKLLKKEERSFEEAIPARKLKNFYPGVAEHKDISKLVLLLSS 991
S I P K EE EE + + NFY ++ + I + +++
Sbjct: 939 --SCIECPPQ------------KGEE---EEVV----IINFYNDISLNPQIIEQAVMIPQ 977
Query: 992 SVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILHYATFEQEIDE 1051
+V+ + + LQ +++Y+ LW D+ + +++F A P ++ Y+ E+
Sbjct: 978 NVHRILINLMKYLQKWKRYRPLWKLDKAIVMEKFAAKKPPCVAYDEKLQFYSKIAYEVMR 1037
Query: 1052 LKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSR 1111
I + L + + AK+W + L + LNE K+++ + + K L +
Sbjct: 1038 HPLIKDEHCIRLQLRHLANTVQENAKSWVISLGKLLNESAKEELYNLHEEMEHLAKNLRK 1097
Query: 1112 PIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYS 1171
L+D++F + ++ IR + M++ ++E Y + + + E E VD +
Sbjct: 1098 IPNTLEDLKFVLATIAEIRSKSLVMELRYRDVQERYRTMAMYNLFPPDAEKELVDKIESI 1157
Query: 1172 FNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPPQEAS 1231
++ L + +V+V+ L ++ F + +R + FA+ + EGP +
Sbjct: 1158 WSNLFNDSVNVEHALGDIKRTFTELTRGEIMNYRVQIEEFAKRFYSEGPGSVGDDLDKGV 1217
Query: 1232 NRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSS 1291
L +++ + ++ E+LF LP+T Y L K +KE++ L+ +Y LY+ + +
Sbjct: 1218 ELLGVYERELARHEKSRQELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVA 1277
Query: 1292 ISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEM 1351
+ + LW +++++ + + F RKLP+ ++ L+ ++ F +S PLL
Sbjct: 1278 KEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIPLLLD 1337
Query: 1352 MTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIE 1411
+ N+A++ RHW + E T F++ +++F L N+ L KH D + +I +AIKE IE
Sbjct: 1338 LKNEALRDRHWKELMEKTSVFFEM-TETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIE 1396
Query: 1412 AKLTQVIENWTNQNLSFAAF-KGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPF 1470
+ ++++ W N + + KG E EII ++D+ L S+ +R+ PF
Sbjct: 1397 KAVKEILDTWENMKFTVVKYCKGTQERGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPF 1456
Query: 1471 KKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIK 1530
+ + W LS ++IE W++VQ W+YLE++F+GGDI QLP+EAK+F NIDK + +
Sbjct: 1457 LQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFIGGDIRSQLPEEAKKFDNIDKVFKR 1516
Query: 1531 IMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPV 1590
IM ++P + CC + L ++ E LE CQKSL YL+ KR FPRFFF+SD
Sbjct: 1517 IMGETLKDPVIKRCCEAPNRLSDL-QNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDE 1575
Query: 1591 LLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDR--IMAVISREGEKIVLDNSVMAK 1648
LL ILG +SD +Q H+ + DNI + F+ D + A+IS EGE + + A+
Sbjct: 1576 LLSILG-SSDPLCVQEHMIKMYDNIASLRFNDGDSGEKLVSAMISAEGEVMEFRKILRAE 1634
Query: 1649 GPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDS 1708
G VE W+ +L + I + A ++ + ++ ++ + V L Q+ WT +
Sbjct: 1635 GRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRV-DWMLLYQGMVVLAASQVWWTWEV 1693
Query: 1709 EEALRNA-KDDRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFD 1767
E+ A K +++ M+ +K ++ L+++ T LSK DR K+ T++ I VH RDI D
Sbjct: 1694 EDVFHKAQKGEKQAMKNYGRKMHRQIDELVTRITMPLSKNDRKKYNTVLIIDVHARDIVD 1753
Query: 1768 DLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDR 1827
++ I +F+W Q RFY+ + D+ + F Y E++G RLVITPLTDR
Sbjct: 1754 SFIRGSILEAREFDWESQLRFYWDREPDELNIRQCTGTFGYGYEYMGLNGRLVITPLTDR 1813
Query: 1828 CYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKG 1887
Y+TL QAL M +GGAPAGPAGTGKTETTKD+ + LG VV NC + MD+R +G+IF G
Sbjct: 1814 IYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG 1873
Query: 1888 LAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFL 1947
LAQ G+WGCFDEFNRI+ VLSV + QI + A + F F +G + L+ GIF+
Sbjct: 1874 LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQF-EGQEISLDSRMGIFI 1932
Query: 1948 TMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLC 2007
TMNPGYAGR ELPE++K FR V ++VPD Q I + L S GFLE LA+K VLYKL
Sbjct: 1933 TMNPGYAGRTELPESVKALFRPVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLA 1992
Query: 2008 EEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLF 2067
EQL+KQ HYDFGLR + SVL G KR + E ++MR LRDMNL K V ED PLF
Sbjct: 1993 REQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLMRALRDMNLPKFVFEDVPLF 2052
Query: 2068 LSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTL 2127
L LI+DLFPGL Y + +AV ++ G P K+VQ++ET L RH M +
Sbjct: 2053 LGLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVV 2112
Query: 2128 GPSGSGKTTVITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLW 2187
GP+ GK+ VI L +AQT+ G + +NPKA++ +++G LD T DWTDG+ S ++
Sbjct: 2113 GPTRGGKSVVINTLCQAQTKLGLTTKLYILNPKAVSVIELYGILDPTTRDWTDGVLSNIF 2172
Query: 2188 RKTLK-AKKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVH 2246
R+ K K E +++ DG VDA+W+EN+NSV+DDN+ LTLANG+RI + C LLFEV
Sbjct: 2173 REINKPTDKKERKYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVG 2232
Query: 2247 NIENASPATVSRMGMVYISSSALSWRPILQAWLKKRTAQEAAVFL-TLYEK--------- 2296
+++ ASPATVSR GMVY+ L +RP + W+ + + L +L+EK
Sbjct: 2233 DLQYASPATVSRCGMVYVDPKNLKYRPYWKKWVNQIPNKVEQYNLNSLFEKYVPYLMDVI 2292
Query: 2297 ---VFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFG 2353
+ + + P+ L N + Q +L+ L+ EG + ++ L F+
Sbjct: 2293 VEGIVDGRQAEKLKTIVPQTDL---NMVTQLAKMLDALL----EGEIEDLDLLECYFLEA 2345
Query: 2354 LMWSLGALLELESREKLEAFLRQHESKLDLP---------EIPKGSNQTMYEFYVTDY-G 2403
L SLGA L + R K + ++++ S + E+P G T+Y+F+ +
Sbjct: 2346 LYCSLGASLLEDGRMKFDEYIKRLASLSTVDTEGVWANPGELP-GQLPTLYDFHFDNKRN 2404
Query: 2404 DWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKT 2463
W W+K + Y + + ++ +ILV VD RT ++++ + K + V+ GE GT+KT
Sbjct: 2405 QWVPWSKLVPEYIHAPER--KFINILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKT 2462
Query: 2464 VMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFID 2523
+ +LK E + +NFSS T M QR +E+ V+KR TYGPP G+++ VF+D
Sbjct: 2463 ATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNLEANVEKRTKDTYGPPMGKRLLVFMD 2522
Query: 2524 DINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIP 2583
D+NMP ++E+G Q +++ ++E +Y K + +I D+ IAAM GGGRN++
Sbjct: 2523 DMNMPRVDEYGTQQPIALLKLLLEKGYLYDRGKELNCKSIRDLGFIAAMGKAGGGRNEVD 2582
Query: 2584 QRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWT 2643
R F+VFN PS S+ I+ I G+ +F I + L L++
Sbjct: 2583 PRFISLFSVFNVPFPSEESLHLIYSSILKGHTS---TFHESIVAVSGKLTFCTLALYKNI 2639
Query: 2644 KVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITP 2703
+ PTPSKFHYIFNLRDLSR++ G++ E ++ ++ ++++EC RV DR I+
Sbjct: 2640 VQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPERFQTVAQMVRVWRNECLRVFHDRLISE 2699
Query: 2704 EDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYEL 2763
D+Q H+ V E+ D + F DF + E P+IYE
Sbjct: 2700 TDKQLVQQHIGSLVVEHFKDDVEVVMRDPILFGDFQMALHEGE-----------PRIYED 2748
Query: 2764 MPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGG 2823
+ ++ Q ++NE T ++LV F DA+ HL ++ RIIR G+ALLVGVGG
Sbjct: 2749 IQDYEAAKALFQEILEEYNE--SNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGG 2806
Query: 2824 SGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIK 2883
SGKQSLSRLA+F A ++F+I L+R Y+ + +DLK+LY G + K + F+FTD+ +
Sbjct: 2807 SGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVA 2866
Query: 2884 DEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHP--PTFDNLYEYFISR 2941
+E FLE +NN+L+SG + LF+ +E + I +S + +E + P +++++YF+++
Sbjct: 2867 EEGFLELINNMLTSGIVPALFSEEEKESI----LSQIGQEALKQGMGPAKESVWQYFVNK 2922
Query: 2942 SRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVC 3001
S NLH+VL SPVG+ R FPG+++ +DWF WP +AL AVA FL YN +
Sbjct: 2923 SANNLHIVLGMSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALHAVAKSFLG-YNPMI 2981
Query: 3002 SSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFIN 3061
+E VV+ + L H V + + Q+ RR +VTPK+YL FIN Y + EK +
Sbjct: 2982 PAENIENVVKHVVLVHQSVDHYSQQFLQKLRRSNYVTPKNYLDFINTYSKLLDEKTQCNI 3041
Query: 3062 EQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKN 3121
Q +R++ GLDKL EA+ + +L+Q LA ++ LA S + +L E+ V+ + + K
Sbjct: 3042 AQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKK 3101
Query: 3122 EVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPH 3181
+E + ++ I EK +AE+ L P LE A+ L + +D+ +R AKPP
Sbjct: 3102 LAEEKAMEIEEQNKVIAMEKAEAETTLAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPK 3161
Query: 3182 LIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINEE 3241
+ + +C+L++ K + +W + +MS FL SL + D+I +
Sbjct: 3162 QVQTVCECILIM-------------KGYKELNWKTAKGVMSDPNFLRSLMEIDFDSITQS 3208
Query: 3242 TVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRL 3301
V+ ++ + T E + V G+L + A+ + + RE+ P + +A+ E
Sbjct: 3209 QVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARLERNF 3268
Query: 3302 AVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLS 3361
+ EL + Q L Q EL+ + AK++AA+ EK L +A+ +++ AA LI GL
Sbjct: 3269 YLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLG 3328
Query: 3362 GEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKIP 3421
E IRW E + +L+GD LLC FLSY G F FR+ ++ W+ ++ R+IP
Sbjct: 3329 SENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMVNRIWQNDILEREIP 3388
Query: 3422 FTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKS 3481
++ L S+L D I WG QGLP D+LS+QNGI+ T+A+R+PL IDPQ Q WIK
Sbjct: 3389 LSQPFRLESLLTDDVEISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKR 3448
Query: 3482 KEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNF-IKSGTTF 3540
KE++N+L+V S N F LE S+ G P L D+ E +DP +DNVLEKN + G F
Sbjct: 3449 KEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVIDNVLEKNIKVSQGRQF 3508
Query: 3541 KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE 3600
+ +GDKE D F+LY+ TKL NP ++P + K VI++TVT+KGLE+QLL ++ E
Sbjct: 3509 -IILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYE 3567
Query: 3601 KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV 3660
++ELE +R L+++ + NK +K+LED+LL +L+ + G+++D+ L+ L TK A EV
Sbjct: 3568 RRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEV 3627
Query: 3661 SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM 3720
SEKL +A +T + I+ ++ +RPAA RG+IL+F+++EM++VN MYQ SL FL++F S+
Sbjct: 3628 SEKLKLAEKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSL 3687
Query: 3721 ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF 3780
+S + KR+ NI++ LT+ ++ + GL+E HK LF MT+KI+ G V E
Sbjct: 3688 KKSLPDSILMKRLRNIMDTLTFSIYNHGCTGLFERHKLLFSFNMTIKIEQAEGRVPQEEL 3747
Query: 3781 QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKL--PQFAEIMNQISRNEKGWKSWF 3838
+KG +L+ K+ KP W+ D W +++ LS++ F ++ + + N+ W+ W+
Sbjct: 3748 DFFLKGNISLE-KSKRKKPCAWLSDQGWEDIILLSEMFSDNFGQLPDDVENNQTVWQEWY 3806
Query: 3839 DKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLE 3898
D D+ E+ +P GY++++ KLL++R + DR Y+ ++ EKY +P +++ E
Sbjct: 3807 DLDSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTMGEKYVQPPMISFE 3866
Query: 3899 KTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKL---ECRTISMGQGQEVHARKLIQMS 3955
+E+S +P++ LS GSDP + LA++ + ++MGQGQE A +L++ +
Sbjct: 3867 AIFEQSTPHSPIVFILSPGSDPATDLMKLAERSGFGGNRLKFLAMGQGQEKVALQLLETA 3926
Query: 3956 MQQGGWVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFT 4015
+ +G W++LQNCHL ++++++L ++L FR+W+TT+P FPI +LQ SLK
Sbjct: 3927 VARGQWLMLQNCHLLVKWLKDLEKSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVV 3986
Query: 4016 NEPPQGVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPY 4075
EPP G++ ++ T+ I+ ++LD P +KP++Y +AF H+ VQERRKFG +GWN+ Y
Sbjct: 3987 TEPPNGLKLNMRATYFKISHEMLDQCPHPAFKPLVYVLAFFHAVVQERRKFGKIGWNVYY 4046
Query: 4076 EFNSADFSASVQFIQNHLDECDIKKG--VSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFA 4133
+FN +DF ++ + +L + ++ + W +++Y+IGEV YGGR D FD+R+L +
Sbjct: 4047 DFNESDFQVCMEILNTYLTKAFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYM 4106
Query: 4134 RVWFSEKMFEPSFCFY------TGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADI 4187
+ + +F+ F+ YKIP+ +++ E I++LP + PEVFGLHPNA+I
Sbjct: 4107 DEYLGDFIFDTFQPFHFFRNKEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEI 4166
Query: 4188 TYQSNTASAVLETITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIK 4247
Y + A + + +QP+ G +R+ + ++++++ +K+P + +V+ RL
Sbjct: 4167 GYYTQAARDMWAHLLELQPQTGESSSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRL-- 4224
Query: 4248 MGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQ 4307
L+ ++ L QE++R +++ + SL++L+ A+ G + MS L D +++ IP
Sbjct: 4225 GTGLSPTSVVLLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPN 4284
Query: 4308 LWKRVSWDS-STLGFWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTR 4366
+W+R++ D+ +LG W L R +Q+ W+ E P+V W++G P+ +LTA+ Q R
Sbjct: 4285 IWRRLAPDTLKSLGNWMVYFLRRFSQYMLWVTESEPSVMWLSGLHIPESYLTALVQATCR 4344
Query: 4367 AHKGWALDTVTIHNEVLR-QTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVL 4425
+ GW LD T+ +V + Q +E+ G+G ++ GLY++GA WD G L++S PKVL
Sbjct: 4345 KN-GWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVL 4403
Query: 4426 FTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTFITVVY---LRTVLSPDHWILRG 4482
LP+L I I + K + P+Y R + + +V+ L T HW+L+G
Sbjct: 4404 VVDLPILKIIPIEAHRLKLQNTFRTPVYTTSMRRNAMGVGLVFEADLFTTRHISHWVLQG 4463
Query: 4483 VAL 4485
V L
Sbjct: 4464 VCL 4466
>gi|75677365 dynein heavy chain domain 3 [Homo sapiens]
Length = 4427
Score = 2087 bits (5406), Expect = 0.0
Identities = 1310/4148 (31%), Positives = 2142/4148 (51%), Gaps = 239/4148 (5%)
Query: 414 ILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLG 473
ILD + T + D+ F I LEV Q + S+F + + LL F +L
Sbjct: 445 ILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRL---ASR 501
Query: 474 LEINHTIER----ILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRIS 529
I T ++ + + +EL + K P L + +GK WV L RRI
Sbjct: 502 EAIKRTYDKKAVDLYMLFNSELALVNR--ERNKKWPDLEPYVAQYSGKARWVHILRRRID 559
Query: 530 EPINYFFKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFV 589
+ + GK + Y ++ + E W + +
Sbjct: 560 RVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQEWTSSLDK----------- 608
Query: 590 RHPETGKLLVNFDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQY 649
+ D +L + +E M+ + D K LL L +++ Y
Sbjct: 609 ------DCIRRLDTPLLRISQEKAGMLDVNFD-----KSLLILFAEI-----------DY 646
Query: 650 YDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQ-LL 708
++ L E P VN+ + + L +L + L + + + +L Q L
Sbjct: 647 WERLLFETPHYVVNV---------AERAEDLRILRENLLLVARDYNRIIAMLSPDEQALF 697
Query: 709 KKISDLCEMHIDTVLKEI------AKTVLISLPESGATKVEDMLTLNE----TYTKEWAD 758
K+ L + I LK++ A I+ A+KV+ + +NE T T W
Sbjct: 698 KERIRLLDKKIHPGLKKLHWALKGASAFFITECRIHASKVQ--MIVNEFKASTLTIGW-- 753
Query: 759 ILNHKSKHVEEAVRELISIFEQIYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANI 818
+++ + E + IS ++++ + +QR+H + + D +
Sbjct: 754 ----RAQEMSEKLLVRISGKRVYRDLEF------EEDQREHRAAVQQKLMNLHQDVVTIM 803
Query: 819 VNEFDTHDKED-EFKKECKEVFAFFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSE 877
N ++ + E +++ + D+L+ + SL + + I
Sbjct: 804 TNSYEVFKNDGPEIQQQWMLYMIRLDRMMEDALRLNVKWSLLELSKAINGDGKTSPNPLF 863
Query: 878 DIISFIKSEVHLAIPNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIP 937
++ +K+++ ++ V P+L + +N + H +P
Sbjct: 864 QVLVILKNDLQGSVAQVEFSPTLQTLAGVVNDIGNHLFSTISVFCH------------LP 911
Query: 938 SPTTTDVTHQNTGKLLKKEERSFEEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLR 997
T H+ + + V + +DI K+ +SS + +
Sbjct: 912 DILTKRKLHREPIQTV----------------------VEQDEDIKKIQTQISSGMTNNA 949
Query: 998 KAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIV 1057
L+ + Y+ +W ++D + + NP ++ ++I Y + + + +
Sbjct: 950 SLLQNYLKTWDMYREIWEINKDSFIHRYQRLNPPVSSFVADIARYTEVANNVQKEETVTN 1009
Query: 1058 VGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLD 1117
+ + L +K +L W+ L E ++ + ++ E +K+SRP + L+
Sbjct: 1010 IQFVLLDCSHLKFSLVQHCNEWQNKFATLLREMAAGRLLELHTYLKENAEKISRPPQTLE 1069
Query: 1118 DVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQS 1177
++ +++ + ++ + ++ + PI E +AIL ++EV V E +D+L + Q
Sbjct: 1070 ELGVSLQLVDALKHDLANVETQIPPIHEQFAILEKYEVPVEDSVLEMLDSLNGEWVVFQQ 1129
Query: 1178 KAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIF 1237
+ ++ L + + KFK+ L+ S + F++ E +E +G N+ A +++
Sbjct: 1130 TLLDSKQMLKKHKEKFKTGLIHSADDFKKKAHTLLEDFEFKGHFTSNVGYMSALDQITQV 1189
Query: 1238 QASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYE 1297
+A + + + + +F + + L KEL+ LQ+++ I+ +E
Sbjct: 1190 RAMLMAMREEENSLRANLGIFKIEQPPSKDLQNLEKELDALQQIW--------EIARDWE 1241
Query: 1298 ILWGD--------VDIEKINAELLEFQNRCRKLPKGLKD--WQAFLDLKKRIDDFSESCP 1347
W + + E + R KL K KD W+ + +I+ F + P
Sbjct: 1242 ENWNEWKTGRFLILQTETMETTAHGLFRRLTKLAKEYKDRNWEIIETTRSKIEQFKRTMP 1301
Query: 1348 LLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKE 1407
L+ + N A+++RHWD++ + FD ES+SF L I+E + +H + I +I SA KE
Sbjct: 1302 LISDLRNPALRERHWDQVRDEIQREFDQESESFTLEQIVELGMDQHVEKIGEISASATKE 1361
Query: 1408 KDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYN 1467
IE L + + W L +K KG L+GTE E+ +ED+ + L ++ ++R+
Sbjct: 1362 LAIEVALQNIAKTWDVTQLDIVPYKDKGHHRLRGTE--EVFQALEDNQVALSTMKASRFV 1419
Query: 1468 APFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKS 1527
F+K++ +W LS ++IE L VQ W+YLE +F+G DI KQLP E+ F ++ +
Sbjct: 1420 KAFEKDVDHWERCLSLILEVIEMILTVQRQWMYLENIFLGEDIRKQLPNESTLFDQVNSN 1479
Query: 1528 WIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVS 1587
W IM R +++ N + + L+ ++ LE QKSL YLE KR +FPRF+F+S
Sbjct: 1480 WKAIMDRMNKDNNALRSTHHPGLLDTLI-EMNTILEDIQKSLDMYLETKRHIFPRFYFLS 1538
Query: 1588 DPVLLEILGQASDSHTIQPHLPAVSDNIN-----EVTFHAKDYDRIMAVISREGEKIVLD 1642
+ LLEILGQ+ + +QPHL DNI +V + ++ + + S +GE I
Sbjct: 1539 NDDLLEILGQSRNPEAVQPHLKKCFDNIKLLRIQKVGGPSSKWEAV-GMFSGDGEYIDFL 1597
Query: 1643 NSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQM 1702
+SV +GPVE WL D+ + +L +++R+ + + ++ + QV + Q+
Sbjct: 1598 HSVFLEGPVESWLGDVEQTMRVTLRDLLRNCHLALRKFLNKRDKWVKEWAGQVVITASQI 1657
Query: 1703 LWTHDSEEALRNAKD--DRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHV 1760
WT D + L AK+ D+KI++V + + ILN +L+K R+K L+TI +
Sbjct: 1658 QWTADVTKCLLTAKERADKKILKVMKKNQVSILNKYSEAIRGNLTKIMRLKIVALVTIEI 1717
Query: 1761 HQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLV 1820
H RD+ + L K + F+WL Q RFY+++DLD V+ T+ F Y E+LG + RLV
Sbjct: 1718 HARDVLEKLYKSGLMDVNSFDWLSQLRFYWEKDLDDCVIRQTNTQFQYNYEYLGNSGRLV 1777
Query: 1821 ITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRG 1880
ITPLTDRCY+TL AL ++ GG+P GPAGTGKTET KD+G+ LG YV+V NCS+ +D++
Sbjct: 1778 ITPLTDRCYMTLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIYVIVVNCSEGLDYKS 1837
Query: 1881 LGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLN 1940
+GR++ GLAQ+G+WGCFDEFNRI + VLSV A QI +L+A F F DG ++L
Sbjct: 1838 MGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAHQILCILSALAAGLTHFHF-DGFEINLV 1896
Query: 1941 PEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKF 2000
GIF+TMNPGYAGR ELPENLK FR +AM+VPD +I + L GF ILA+K
Sbjct: 1897 WSCGIFITMNPGYAGRTELPENLKSMFRPIAMVVPDSTLIAEIILFGEGFGNCKILAKKV 1956
Query: 2001 YVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLV 2060
Y LY L +QL++Q HYDFGLR + S+LR G ++R +P+ ++ +++ +RDMN++KL
Sbjct: 1957 YTLYSLAVQQLSRQDHYDFGLRALTSLLRYAGKKRRLQPDLTDEEVLLLSMRDMNIAKLT 2016
Query: 2061 DEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLV 2120
D PLF +++ DLFP ++L Y +L+ V +++ GL + P K+ QLYET
Sbjct: 2017 SVDAPLFNAIVQDLFPNIELPVIDYGKLRETVEQEIRDMGLQSTPFTLTKVFQLYETKNS 2076
Query: 2121 RHGLMTLGPSGSGKTTVITIL---MKAQTECGRPH----REMRMNPKAITAPQMFGRLDT 2173
RH M +G +GSGKT IL + + G P+ RE +NPKA++ +++G D
Sbjct: 2077 RHSTMIVGCTGSGKTASWRILQASLSSLCRAGDPNFNIVREFPLNPKALSLGELYGEYDL 2136
Query: 2174 ATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRI 2233
+TN+WTDGI S++ R +K + +++ DGPVD +WIEN+NSV+DDNK LTL NG+RI
Sbjct: 2137 STNEWTDGILSSVMRTACADEKPDEKWILFDGPVDTLWIENMNSVMDDNKVLTLINGERI 2196
Query: 2234 PMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLKKRTAQEAAVFLTL 2293
M LLFEV ++ ASPATVSR GMVY + L W+P +Q+WL+KR E +
Sbjct: 2197 AMPEQVSLLFEVEDLAMASPATVSRCGMVYTDYADLGWKPYVQSWLEKRPKAEVEPLQRM 2256
Query: 2294 YEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEG-----GVSCVEHLHK 2348
+EK+ + K N + L E + I SL L + + E G G + V +
Sbjct: 2257 FEKLINKMLAFKKDNCKELVPLPEYSGIT-SLCKLYSALATPENGVNPADGENYVTMVEM 2315
Query: 2349 LFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVTD-YGDWEH 2407
FVF ++WS+ A ++ E R++++++LR+ E + T+YE++V W
Sbjct: 2316 TFVFSMIWSVCASVDEEGRKRIDSYLREIEGSFP-------NKDTVYEYFVDPKIRSWTS 2368
Query: 2408 WNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVK 2467
+ KL + + P Y I+VP VD +R N+L+ ++ +LL G GT KT + +
Sbjct: 2369 FEDKLPKSWRYPPNAPFYK-IMVPTVDTVRYNYLVSSLVANQNPILLVGPVGTGKTSIAQ 2427
Query: 2468 AYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINM 2527
+ L+ +N S+ T Q IES V+KR Y P GG+ M F+DD+NM
Sbjct: 2428 SVLQSLPSSQWSVLVVNMSAQTTSNNVQSIIESRVEKRTKGVYVPFGGKSMITFMDDLNM 2487
Query: 2528 PVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLK 2587
P + +G Q E++R ++ Y K I ++ L+AAM PGGGR I RL+
Sbjct: 2488 PAKDMFGSQPPLELIRLWIDYGFWYDRTKQ-TIKYIREMFLMAAMGPPGGGRTVISPRLR 2546
Query: 2588 RQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRV-LWQWTKVK 2646
+F + N T P+ + I +IFG + + F+ ++ + I N+V+ + ++ +
Sbjct: 2547 SRFNIINMTFPTKSQIIRIFGTM---INQKLQDFEEEV-KPIGNVVTEATLDMYNTVVQR 2602
Query: 2647 MLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDE 2706
LPTP+K HY+FNLRD+S+++QGML + + ++ L+ HEC RV +DR + D
Sbjct: 2603 FLPTPTKMHYLFNLRDISKVFQGMLRANKDFHDTKSSITRLWIHECFRVFSDRLVDAADT 2662
Query: 2707 QWFNAHLTRAVEENIGSD---AASCILPE---PYFVDFLREMPEPTGDEPEDSVFEVPKI 2760
+ F + + +GS + P P F DFL+E PK+
Sbjct: 2663 EAFMG----IISDKLGSFFDLTFHHLCPSKRPPIFGDFLKE----------------PKV 2702
Query: 2761 YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG 2820
YE + L ++ ++N + LV F++A+ H+ +I R+I GN LLVG
Sbjct: 2703 YEDLTDLTVLKTVMETALNEYNLSPSVVPMQLVLFREAIEHITRIVRVIGQPRGNMLLVG 2762
Query: 2821 VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS 2880
+GGSG+QSL+RLAS I Y FQI +T+ Y DD+K LY+ AG + K +FIF D+
Sbjct: 2763 IGGSGRQSLARLASSICDYTTFQIEVTKHYRKQEFRDDIKRLYRQAGVELKTTSFIFVDT 2822
Query: 2881 EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS 2940
+I DE+FLE +NN+LSSGE+ NL+ DE +EI +I + E + P + D+L+ Y I
Sbjct: 2823 QIADESFLEDINNILSSGEVPNLYKPDEFEEIQSHIIDQARVE--QVPESSDSLFAYLIE 2880
Query: 2941 RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV 3000
R + NLH+VLC SP+G+ FR ++P L++ T++WFS WP+EAL+ VA L ++
Sbjct: 2881 RVQNNLHIVLCLSPMGDPFRNWIRQYPALVNCTTINWFSEWPQEALLEVAEKCLIGVDLG 2940
Query: 3001 CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI 3060
I R+V + H V++ + RR +VTP YL ++GYK + EK + +
Sbjct: 2941 TQENIHRKVAQIFVTMHWSVAQYSQKMLLELRRHNYVTPTKYLELLSGYKKLLGEKRQEL 3000
Query: 3061 NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK 3120
QA ++ GL K+ E E V +S +L +K++A + +E L + Q +
Sbjct: 3001 LAQANKLRTGLFKIDETREKVQVMSLELEDAKKKVAEFQKQCEEYLV---IIVQQKREAD 3057
Query: 3121 NEVQEVKDKAQKI-VDEIDSEKV--KAESKLEAAKPALEEAEAALNTIKPNDIATVRKLA 3177
+ + V ++KI V+EI + + A+ LE A PALEEA AL ++ DI ++
Sbjct: 3058 EQQKAVTANSEKIAVEEIKCQALADNAQKDLEEALPALEEAMRALESLNKKDIGEIKSYG 3117
Query: 3178 KPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDT 3237
+PP + +M V++L + P+W E+ + + F+ SL F KD
Sbjct: 3118 RPPAQVEIVMQAVMILRGNE--------------PTWAEAKRQLGEQNFIKSLINFDKDN 3163
Query: 3238 INEETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQ 3297
I+++ ++ + Y D+ + +V L W AM ++ + R V P + +
Sbjct: 3164 ISDKVLKKIGAYCAQPDFQPDIIGRVSLAAKSLCMWVRAMELYGRLYRVVEPKRIRMNAA 3223
Query: 3298 EGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLI 3357
+L A L +AQ L E +L+ ++ ++D + +K +L ++ K++ A L+
Sbjct: 3224 LAQLREKQAALAEAQEKLREVAEKLEMLKKQYDEKLAQKEELRKKSEEMELKLERAGMLV 3283
Query: 3358 DGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRA 3417
GL+GEK RW + + + + LVGD LL FLSY+GPF +R+ ++ W ++
Sbjct: 3284 SGLAGEKARWEETVQGLEEDLGYLVGDCLLAAAFLSYMGPFLTNYRDEIVNQIWIGKIWE 3343
Query: 3418 RKIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKT 3477
++P + + + + L +P + +W +QGLP D S +NGIIVT+ R+ L+IDPQ Q
Sbjct: 3344 LQVPCSPSFAIDNFLCNPTKVRDWNIQGLPSDAFSTENGIIVTRGNRWALMIDPQAQALK 3403
Query: 3478 WIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSG 3537
WIK+ E L++ L + LE ++ G P+L++++ E LDP L+ +L K+ + G
Sbjct: 3404 WIKNMEGGQGLKIIDLQMSDYLRILEHAIHFGYPVLLQNVQEYLDPTLNPMLNKSVARIG 3463
Query: 3538 TTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVI 3597
+++GDKE + F+ YITTKL NP ++PE +AKT++++F V +GLE QLL V+
Sbjct: 3464 GRLLMRIGDKEVEYNTNFRFYITTKLSNPHYSPETSAKTTIVNFAVKEQGLEAQLLGIVV 3523
Query: 3598 LTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTA 3657
E+ ELE ++ L+ ++ KRK+KELED +L L+ GSL+DD L+ L T+K TA
Sbjct: 3524 RKERPELEEQKDSLVINIAAGKRKLKELEDEILRLLNEATGSLLDDVQLVNTLHTSKITA 3583
Query: 3658 AEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFD 3717
EV+E+L + TEI + A+E +RP A R SIL+F++ +M ++ MYQ SL ++ LF
Sbjct: 3584 TEVTEQLETSETTEINTDLAREAYRPCAQRASILFFVLNDMGCIDPMYQFSLDAYISLFI 3643
Query: 3718 QSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKH 3777
S+ +S +S + RI + +Y TY V+ Y+ R L+E HK LF M KI G +
Sbjct: 3644 LSIDKSHRSNKLEDRIDYLNDYHTYAVYRYTCRTLFERHKLLFSFHMCAKILETSGKLNM 3703
Query: 3778 REFQALIKGGAALDLKACPPKP-YRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKS 3836
E+ ++GG LD + P W+ D W N+ EL KL F +MN + + W
Sbjct: 3704 DEYNFFLRGGVVLDREGQMDNPCSSWLADAYWDNITELDKLTNFHGLMNSFEQYPRDWHL 3763
Query: 3837 WFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILN 3896
W+ APE+ ++P + ++ + ++L++RS DR F +I +L ++ EP +LN
Sbjct: 3764 WYTNAAPEKAMLPGEWENACNEMQRMLIVRSLRQDRVAFCVTSFIITNLGSRFIEPPVLN 3823
Query: 3897 LEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECR--TISMGQGQEVHARKLIQM 3954
++ E+S R+PL+ LS G DPT+ + LA+ + + R +S+GQGQ A +L++
Sbjct: 3824 MKSVLEDSTPRSPLVFILSPGVDPTSALLQLAEHMGMAQRFHALSLGQGQAPIAARLLRE 3883
Query: 3955 SMQQGGWVLLQNCHLGLEFMEEL--LETLITTEASDDSFRVWITTEPHDRFPITLLQTSL 4012
+ QG WV L NCHL L +M L L + E SFR+W+++ PH FPI++LQ S+
Sbjct: 3884 GVTQGHWVFLANCHLSLSWMPNLDKLVEQLQVEDPHPSFRLWLSSIPHPDFPISILQVSI 3943
Query: 4013 KFTNEPPQGVRAGLKRTFAGINQDLLDISNLP-MWKPMLYTVAFLHSTVQERRKFGPLGW 4071
K T EPP+G++A + R + +++ + P +K +L+++ F HS + ER+KF LGW
Sbjct: 3944 KMTTEPPKGLKANMTRLYQLMSEPQFSRCSKPAKYKKLLFSLCFFHSVLLERKKFLQLGW 4003
Query: 4072 NIPYEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNC 4131
NI Y FN +DF S + +LDE + W+ ++Y+I + YGG VTDD+D+RLL
Sbjct: 4004 NIIYGFNDSDFEVSENLLSLYLDEYE---ETPWDALKYLIAGINYGGHVTDDWDRRLLTT 4060
Query: 4132 FARVWFSEKMFEPSFCFYTG---YKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADIT 4188
+ +F ++ F + Y IP +L Y EYI LP +D PE FG HPNAD+
Sbjct: 4061 YINDYFCDQSLSTPFHRLSALETYFIPKDGSLASYKEYISLLPGMDPPEAFGQHPNADVA 4120
Query: 4189 YQSNTASAVLETITNIQPKESGGGV-GETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIK 4247
Q A + +T+ ++QP+ + G+TRE V L+ D+ K+ P+ I +E +L+
Sbjct: 4121 SQITEAQTLFDTLLSLQPQITPTRAGGQTREEKVLELAADVKQKI-PEMIDYEGTQKLLA 4179
Query: 4248 MGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQ 4307
+ + +N+ L QEI R ++ + SL+DL+ I+G I+MS +L + + ++DA +P
Sbjct: 4180 LDP-SPLNVVLLQEIQRYNTLMQTILFSLTDLEKGIQGLIVMSTSLEEIFNCIFDAHVPP 4238
Query: 4308 LWKRVSWDSSTLGFWFTELLERNAQFSTWIFEGRPNV-FWMTGFFNPQGFLTAMRQEVTR 4366
LW + L W +L R QF W RP V FW++GF P GFLTA+ Q R
Sbjct: 4239 LWGKAYPSQKPLAAWTRDLAMRVEQFELWASRARPPVIFWLSGFTFPTGFLTAVLQSSAR 4298
Query: 4367 AHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLF 4426
++D+++ V + PP +GV++ GLY++GA WDR+N L+E+ P L
Sbjct: 4299 -QNNVSVDSLSWEFIVSTVDDSNLVYPPKDGVWVRGLYLEGAGWDRKNSCLVEAEPMQLV 4357
Query: 4427 TQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTD----LTFITVVYLRT-VLSPDHWILR 4481
+P +H S +Y CP Y P R +F+ + LR+ ++PDHWI R
Sbjct: 4358 CLMPTIHFRPAESRKKSAKGMYSCPCYYYPNRAGSSDRASFVIGIDLRSGAMTPDHWIKR 4417
Query: 4482 GVALLCDI 4489
G ALL +
Sbjct: 4418 GTALLMSL 4425
Score = 88.6 bits (218), Expect = 1e-16
Identities = 69/243 (28%), Positives = 116/243 (47%), Gaps = 35/243 (14%)
Query: 57 MLANIFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTID 116
+L +F P + A W ES ++ F ++++L+ L R +EG
Sbjct: 174 LLGGVFAPQIFANTGWP--------ESIRNHFASHLHKFLACLTDTRYKLEG-------- 217
Query: 117 NVNFSKLHTFEEVTAAASN---------SETVHQLEEVLMVWYKQIEQVLIESEQMRKEA 167
HT + A A N E V +LE ++ W +QI+++L S Q E
Sbjct: 218 -------HTVLYIPAEAMNMKPEMVIKDKELVQRLETSMIHWTRQIKEML--SAQETVET 268
Query: 168 GDS-GPLTELEHWKRMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDT 226
G++ GPL E+E W+ + I +Q+ K V ++L++A S L + L +I D
Sbjct: 269 GENLGPLEEIEFWRNRCMDLSGISKQLVKKGVKHVESILHLAKSSYLAPFMKLAQQIQDG 328
Query: 227 ANESKDNVRYLYTLEKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLF 286
+ +++ N+ +L L++ Q L ++ + LI+ IR+I S +YNT ER+TSLF
Sbjct: 329 SRQAQSNLTFLSILKEPYQELAFMKPKDISSKLPKLISLIRIIWVNSPHYNTRERLTSLF 388
Query: 287 IKV 289
KV
Sbjct: 389 RKV 391
>gi|197927452 dynein, axonemal, heavy chain 1 [Homo sapiens]
Length = 4265
Score = 2031 bits (5261), Expect = 0.0
Identities = 1230/3606 (34%), Positives = 1949/3606 (54%), Gaps = 170/3606 (4%)
Query: 982 ISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILH 1041
+ +L ++S+V+ ++++KY L D +K + E+R +L
Sbjct: 726 VEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT 785
Query: 1042 YATFEQEIDELKPI-IVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIA 1100
+ ++ +D P I++G ++T+ +K +LS + KA + L + K++ +
Sbjct: 786 HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICE 845
Query: 1101 FINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKE 1160
+K+ ++++ E + I + + ++ + + + Y +++ F ++ +
Sbjct: 846 EFRSISRKIYEKPNSIEELAELREWMKGIPERLVGLEERIVKVMDDYQVMDEFLYNLSSD 905
Query: 1161 ESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFK-------SNLLESVEVFREDVINFAE 1213
+ +K+ + VQ+ V+ + KF+ +N E +E + V F+
Sbjct: 906 DFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI 965
Query: 1214 AYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRK 1273
E+ E +N ++ + D + + Y++ E++F LP+T+Y+ L + K
Sbjct: 966 HVEISRA-------HEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVK 1018
Query: 1274 ELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAF- 1332
E L+ + + +D E++ ++E K K KD A
Sbjct: 1019 EFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVVEAFKTMHKCVKQFKDMPACQ 1078
Query: 1333 ---LDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAP 1389
LD++ RI++F PL++ + N M+ RHW+ +S +++ R +E
Sbjct: 1079 EVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFAR-CLEMN 1137
Query: 1390 LLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIIT 1449
L H + I + A KE IE L ++ + W+ + +K +LK + E
Sbjct: 1138 LQDHIESISKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPD--EASQ 1195
Query: 1450 LMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGD 1509
L++D +++ ++ + Y PF++ I +W KL + +++EEWL Q W+YLE +F D
Sbjct: 1196 LLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLEEWLNCQRSWLYLEPIFSSED 1255
Query: 1510 IAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSL 1569
I +QLP E+KR+Q +++ W KIM+ A+EN VIN C D M L ++ L++ QK L
Sbjct: 1256 INQQLPVESKRYQTMERIWKKIMKNAYENREVINVC-SDLRMLDSLRDCNKILDLVQKGL 1314
Query: 1570 TGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDRIM 1629
+ YLE KR FPRF+F+SD LLEIL Q D +QPHL +NI + F +D + I
Sbjct: 1315 SEYLETKRSAFPRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQ-EDLE-IT 1372
Query: 1630 AVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLP--- 1686
+ S EGE++ L S+ VE WL ++ + +S+H+II A + +P
Sbjct: 1373 HMYSAEGEEVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEKAI-----RAYPTMPRTQ 1427
Query: 1687 FLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQTTHDLSK 1746
++ ++P QV + G Q WT + EAL ++ Q+ D L++ LS+
Sbjct: 1428 WVLNWPGQVTIAGCQTYWTMEVAEALEAGNLRSQLFPQLCQQLSD----LVALVRGKLSR 1483
Query: 1747 FDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDF 1806
R LI I VH +D+ L++ ++ S DF+W+ Q R+Y+ + + + +F
Sbjct: 1484 MQRAVLSALIVIEVHAKDVVSKLIQENVVSVNDFQWISQLRYYWTNN--DLYIRAVNAEF 1541
Query: 1807 IYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCLGKY 1866
IY E+LG + RLVITPLTDRCY+TL AL + GGAPAGPAGTGKTETTKD+G+ L
Sbjct: 1542 IYGYEYLGNSGRLVITPLTDRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLGKALAIQ 1601
Query: 1867 VVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARKERK 1926
VVFNCSDQ+DF +G+ FKGLA +G+W CFDEFNRI++ VLSV AQQI + A+++R
Sbjct: 1602 TVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRV 1661
Query: 1927 KQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRVKLA 1986
++F+F +G + L P +F+TMNPGYAGR ELP+NLK FR VAMMVPD +I + L
Sbjct: 1662 ERFMF-EGVEIPLVPSCAVFITMNPGYAGRTELPDNLKALFRPVAMMVPDYAMITEISLY 1720
Query: 1987 SCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSELSI 2046
S GF E +LA+K +KL EQL+ Q HYDFG+R + +V+ G+ KR P +E I
Sbjct: 1721 SFGFNEASVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSMNEELI 1780
Query: 2047 VMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLINHPP 2106
+R +RD+N+ K + ED LF +++DLFP ++ + Y L A+ + L +
Sbjct: 1781 CLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEG 1840
Query: 2107 WNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTEC-GRPHREMRM-------- 2157
+ K +QLYET++VRHGLM +GP+GSGK+T +L A T G+P M
Sbjct: 1841 FLTKCIQLYETTVVRHGLMLVGPTGSGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYV 1900
Query: 2158 -NPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLN 2216
NPK+IT Q++G D T++WTDGIFS+ R + + DGPVDAIWIEN+N
Sbjct: 1901 LNPKSITMGQLYGEFDLLTHEWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIWIENMN 1960
Query: 2217 SVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQ 2276
+VLDDNK L L++G+ I + + ++FEV ++ ASPATVSR GMVY+ S L P ++
Sbjct: 1961 TVLDDNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIE 2020
Query: 2277 AWLKK-----RTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLL--- 2328
WL+K + +E F L+ E++ ++++ ++ + CN + L LL
Sbjct: 2021 CWLRKLPPLLKPYEEH--FKALFVSFLEESISFVRSSVKEVIASTNCNLTMSLLKLLDCF 2078
Query: 2329 -------EGL--IPSKEEGGVSCVEHLHKLFVFGLMWSLGALLELESREKLEAFLR---- 2375
EGL IPS++ + VE + F+F L+WS+GA + R +LR
Sbjct: 2079 FKPFLPREGLKKIPSEKLSRI--VELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKME 2136
Query: 2376 QHESKLDLPEIP------------KGSNQTMYEFYVTDYGDWEHWNKKLQPYYYPTDSIP 2423
+ L PE G+N + E W W P+ D+
Sbjct: 2137 NEQLTLLFPEEGLVFDYRLEDAGISGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDT-- 2194
Query: 2424 EYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSL 2483
Y +I+VP +D ++ + L+D + K VL G GT KT+ + L K +S L
Sbjct: 2195 NYCNIIVPTMDTVQMSHLLDMLLTNKKPVLCIGPTGTGKTLTISDKLLKNLALDYISHFL 2254
Query: 2484 NFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVR 2543
FS+ T Q I+S +DKR +GPP GR FIDD+NMP + +G Q E++R
Sbjct: 2255 TFSARTSANQTQDFIDSKLDKRRKGVFGPPLGRNFIFFIDDLNMPALETYGAQPPIELLR 2314
Query: 2544 QMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASI 2603
Q M+ G Y G F +VD+ + AM PGGGRN + RL R F + S
Sbjct: 2315 QWMDHGGWYDRKIIGAFKNLVDINFVCAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSK 2374
Query: 2604 DKIFGIIGCGYFDPCRSFK---------PQICEMIVNLVSVGRVLWQWTKVKMLPTPSKF 2654
+IF I + D K P I LV +++ ++LPTP+K
Sbjct: 2375 KRIFSTILGNWLDGLLGEKSYRERVPGAPHIAHFTEPLVEATIMVYATITSQLLPTPAKS 2434
Query: 2655 HYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLT 2714
HY FNLRDLS+++QGML + LL L+ HE RV DR + ED WF+ L
Sbjct: 2435 HYTFNLRDLSKVFQGMLMADPAKVEDQVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLK 2494
Query: 2715 RAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKL 2774
R +E+ + C + DF+ P V K YEL+ S + + +
Sbjct: 2495 RCMEQWEVTFNKVCPFQPILYGDFM---------SPGSDV----KSYELITSESKMMQVI 2541
Query: 2775 QFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLAS 2834
+ Y +N+I L LV F DAM+H+ +ISR +R + GNALL+GVGGSG+ SL+RLAS
Sbjct: 2542 EEYIEDYNQI-NTAKLKLVLFMDAMSHICRISRTLRQALGNALLLGVGGSGRSSLTRLAS 2600
Query: 2835 FIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNL 2894
+A Y+ FQI L+++Y ++ DD+K + AG ITF+F+D++IK+E+FLE +NN+
Sbjct: 2601 HMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPITFLFSDTQIKNESFLEDINNV 2660
Query: 2895 LSSGEISNLFARDEMDEITQGLISVMKRELPRH--PPTFDNLYEYFISRSRKNLHVVLCF 2952
L+SG+I NL+ DE D+I +S M+ + PT NL + R R N+H+VLC
Sbjct: 2661 LNSGDIPNLYTADEQDQI----VSTMRPYIQEQGLQPTKANLMAAYTGRVRSNIHMVLCM 2716
Query: 2953 SPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQ-VVE 3011
SP+GE FRAR +FP L++ CT+DWF+ WP EAL +VA+ FL++ + SS+ + Q +++
Sbjct: 2717 SPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNEIPELESSQEEIQGLIQ 2776
Query: 3012 TMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGL 3071
H VS+ C Y R +VTPKSYL ++ + + +K + RM GL
Sbjct: 2777 VCVYIHQSVSKKCIEYLAELTRHNYVTPKSYLELLHIFSILIGQKKLELKTAKNRMKSGL 2836
Query: 3072 DKLMEASESVAKLSQDL---------AVKEKELAVASIKADEVLAEVTVSAQASAKIKNE 3122
DKL+ SE VAK+ +DL A K+ L + IK D +AE T ++ + +IK
Sbjct: 2837 DKLLRTSEDVAKMQEDLESMHPLLEEAAKDTMLTMEQIKVDTAIAEETRNSVQTEEIK-- 2894
Query: 3123 VQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHL 3182
E KAQ I D+ A+ L+ A PAL+ A A+L + ND+ VR + +PP
Sbjct: 2895 ANEKAKKAQAIADD-------AQKDLDEALPALDAALASLRNLNKNDVTEVRAMQRPPPG 2947
Query: 3183 IMRIMDCVLLLFQKKIDPVTMDPEKSCCKPS--WGESLKLMSATG-FLWSLQQFPKDTIN 3239
+ +++ V ++ K I P + EK K W L+ G FL SL +F KD I
Sbjct: 2948 VKLVIEAVCIM--KGIKPKKVPGEKPGTKVDDYWEPGKGLLQDPGHFLESLFKFDKDNIG 3005
Query: 3240 EETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEG 3299
+ ++ +QPY + +++ + KV + W AM ++ + + V P + L + +
Sbjct: 3006 DVVIKAIQPYIDNEEFQPATIAKVSKACTSICQWVRAMHKYHFVAKAVEPKRQALLEAQD 3065
Query: 3300 RLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDG 3359
L V L +A+ L E + + +QAK+ + +K +L + C +++ A LI+G
Sbjct: 3066 DLGVTQRILDEAKQRLREVEDGIATMQAKYRECITKKEELELKCEQCEQRLGRAGKLING 3125
Query: 3360 LSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARK 3419
LS EK+RW + + + +N + GD+L+ GF++YLGPF +R +L D W +LR+
Sbjct: 3126 LSDEKVRWQETVENLQYMLNNISGDVLVAAGFVAYLGPFTGQYRT-VLYDSWVKQLRSHN 3184
Query: 3420 IPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWI 3479
+P T LI L +P I W + GLP D LS++NG+I + R+ IDPQ+Q WI
Sbjct: 3185 VPHTSEPTLIGTLGNPVKIRSWQIAGLPNDTLSVENGVINQFSQRWTHFIDPQSQANKWI 3244
Query: 3480 KSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTT 3539
K+ EK+N L V L+ + F +E+++ G+P L+E++ EELDPAL+ VL K K
Sbjct: 3245 KNMEKDNGLDVFKLSDRDFLRSMENAIRFGKPCLLENVGEELDPALEPVLLKQTYKQQGN 3304
Query: 3540 FKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILT 3599
+K+GD + F++YITTKLPNP +TPEI+ K ++I+FT++ GLE+QLL +V+
Sbjct: 3305 TVLKLGDTVIPYHEDFRMYITTKLPNPHYTPEISTKLTLINFTLSPSGLEDQLLGQVVAE 3364
Query: 3600 EKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAE 3659
E+ +LE + +L+ ++++K++ED +LY+LS+++G+ VDD LI VL +K AAE
Sbjct: 3365 ERPDLEEAKNQLIISNAKMRQELKDIEDQILYRLSSSEGNPVDDMELIKVLEASKMKAAE 3424
Query: 3660 VSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQS 3719
+ K+ +A +TE I+ + E+ P A R IL+F +++++ V+ MYQ SL FL +F
Sbjct: 3425 IQAKVRIAEQTEKDIDLTRMEYIPVAIRTQILFFCVSDLANVDPMYQYSLEWFLNIFLSG 3484
Query: 3720 MARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHRE 3779
+A SE++ +KRI+NI YLTY +++ R L+E HK +F L+ ++I + G + E
Sbjct: 3485 IANSERADNLKKRISNINRYLTYSLYSNVCRSLFEKHKLMFAFLLCVRIMMNEGKINQSE 3544
Query: 3780 FQALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFD 3839
++ L+ GG ++ + P P W+ D W +++ LS LP F+ + ++ ++ FD
Sbjct: 3545 WRYLLSGG-SISIMTENPAP-DWLSDRAWRDILALSNLPTFSSFSSDFVKHLSEFRVIFD 3602
Query: 3840 KDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEK 3899
P E +P ++ LD KLL++R D+ + ++A +LE ++ EP NL
Sbjct: 3603 SLEPHREPLPGIWDQYLDQFQKLLVLRCLRGDKVTNAMQDFVATNLEPRFIEPQTANLSV 3662
Query: 3900 TWEESDTRTPLICFLSMGSDPTNQIDALAKKLKL--ECRTISMGQGQEVHARKLIQMSMQ 3957
+++S++ TPLI LS G+DP + A+++K + IS+GQGQ A +++ S++
Sbjct: 3663 VFKDSNSTTPLIFVLSPGTDPAADLYKFAEEMKFSKKLSAISLGQGQGPRAEAMMRSSIE 3722
Query: 3958 QGGWVLLQNCHLGLEFM---EELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKF 4014
+G WV QNCHL +M E L+E + + D FR+W+T+ P ++FP+++LQ K
Sbjct: 3723 RGKWVFFQNCHLAPSWMPALERLIEHINPDKVHRD-FRLWLTSLPSNKFPVSILQNGSKM 3781
Query: 4015 TNEPPQGVRAGLKRTFAGINQDLLDISNLPM-WKPMLYTVAFLHSTVQERRKFGPLGWNI 4073
T EPP+GVRA L ++++ + +D L+ + M +K +L ++ H ERRKFGPLG+NI
Sbjct: 3782 TIEPPRGVRANLLKSYSSLGEDFLNSCHKVMEFKSLLLSLCLFHGNALERRKFGPLGFNI 3841
Query: 4074 PYEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFA 4133
PYEF D + ++ LDE D + + ++Y GE+ YGGRVTDD+D+R +
Sbjct: 3842 PYEFTDGDLRICISQLKMFLDEYD---DIPYKVLKYTAGEINYGGRVTDDWDRRCIMNIL 3898
Query: 4134 RVWFSEKMFEPSFCFYTG---YKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQ 4190
+++ + P + ++IP L Y YI+SLP D PE+FGLH NA+IT+
Sbjct: 3899 EDFYNPDVLSPEHSYSASGIYHQIPPTYDLHGYLSYIKSLPLNDMPEIFGLHDNANITFA 3958
Query: 4191 SNTASAVLETITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGH 4250
N A+L TI +QPK S G + RE IV +++++L K+P V ++ + +
Sbjct: 3959 QNETFALLGTIIQLQPKSSSAG-SQGREEIVEDVTQNILLKVPEPINLQWVMAKYPVL-Y 4016
Query: 4251 LNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWK 4310
SMN L QE+ R R++ ++ +L DL A++G ++MS L ++Y+ +P+LW
Sbjct: 4017 EESMNTVLVQEVIRYNRLLQVITQTLQDLLKALKGLVVMSSQLELMAASLYNNTVPELWS 4076
Query: 4311 RVSWDS-STLGFWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHK 4369
++ S L W +LL+R WI +G P VFW++GFF PQ FLT Q R
Sbjct: 4077 AKAYPSLKPLSSWVMDLLQRLDFLQAWIQDGIPAVFWISGFFFPQAFLTGTLQNFARKFV 4136
Query: 4370 GWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQL 4429
++DT++ +V+ + E+T P G YI+GL+++GA WD +L ES PK L+T++
Sbjct: 4137 -ISIDTISFDFKVMFEAPSELTQRPQVGCYIHGLFLEGARWDPEAFQLAESQPKELYTEM 4195
Query: 4430 PVLHIFAINSTAPKDPKLYVCPIYKKPRRT--------DLTFITVVYLRTVLSPDHWILR 4481
V+ + + +D Y+CPIYK R ++ V + T HWI R
Sbjct: 4196 AVIWLLPTPNRKAQDQDFYLCPIYKTLTRAGTLSTTGHSTNYVIAVEIPTHQPQRHWIKR 4255
Query: 4482 GVALLC 4487
GVAL+C
Sbjct: 4256 GVALIC 4261
>gi|194353966 dynein, axonemal, heavy polypeptide 6 [Homo sapiens]
Length = 4158
Score = 1964 bits (5088), Expect = 0.0
Identities = 1195/3732 (32%), Positives = 1985/3732 (53%), Gaps = 193/3732 (5%)
Query: 873 RKQSEDIISFIKSEVHLAIPNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPI 932
+++ E +I +E+ L + +++ PSL+D I G + Q + +
Sbjct: 503 QEEDESLIPMFLTELMLTVQSLLFEPSLEDFLDGI-----------LGAVNHCQNTVLSV 551
Query: 933 KSVIPSPTTTDVTHQNTGKLLKKEERSFEEAIPA--RKLKNFYPGVAEHKDISKLVLLLS 990
+++P T L+ + ++ A KNF+ +++ K+
Sbjct: 552 PNLVPDSYFDAFTSPYINNKLEGKTCGTGPSLAAVFEDDKNFHTIISQIKE--------- 602
Query: 991 SSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILHYATFEQEID 1050
++ + ++A F+K++ + E+ + ++ P + ++ Y ++
Sbjct: 603 -TIQAAFESARIYAATFEKFQIFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAV 661
Query: 1051 ELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLS 1110
L+P VG L + T ++ L +L L + KKK+ +I + KL
Sbjct: 662 ALRPTRNVGLLLIDTRLLREKLIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLE 721
Query: 1111 RPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRY 1170
+ ++ L I++ ++ + + Y ++ +++V E+ T++
Sbjct: 722 FVPTTTTEYVHSLLFLDEIQERIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKP 781
Query: 1171 SFNKLQS---KAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPP 1227
S +++ K+V +E ++ +F +L +E +V + + P + +I
Sbjct: 782 SIVAVRNAIDKSVGDRESSIK---QFCVHLGSDLEELNNEVNEVK--LQAQDPQILDISA 836
Query: 1228 QEASNRLQI--FQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLY 1285
+ RL + Q+ DL ++ Y S ++ F + V+ +E L + EL L Q L+ +
Sbjct: 837 DQDKIRLILNNLQSVLADLQKRAFQYKSYQKNFKVEVSKFEALEEVSAELKLKQLLWDSF 896
Query: 1286 DTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSES 1345
+ + + +D E +N ++ ++ +L KGL LK +++ E
Sbjct: 897 SEWDKLQQEWLKSKFDCLDPEVLNGQVSKYAKFVTQLEKGLPPNSVVPQLKYKVEKMKEK 956
Query: 1346 CPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAI 1405
P++ + N +K RHW I + L + + + +I+DI A
Sbjct: 957 LPVIIDLRNPTLKARHWAAIEQTVDATLVDAEIPLTLERLSQLHVFDFGQEIQDISGQAS 1016
Query: 1406 KEKDIEAKLTQVIENW-TNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSN 1464
E +EA L +V ++W T + + K +L GT+ +I L++DS + + +L S+
Sbjct: 1017 GEAALEAILKKVEDSWKTTEFVILPHRDSKDVFILGGTD--DIQVLLDDSTINVATLASS 1074
Query: 1465 RYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQNI 1524
RY P K + W +L+ + +EEWL Q W+YLE++F DI +QLP EAK F +
Sbjct: 1075 RYLGPLKTRVDEWQKQLALFNQTLEEWLTCQRNWLYLESIFNAPDIQRQLPAEAKMFLQV 1134
Query: 1525 DKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFF 1584
DKSW +IM++ + PN + + + + + L+ QK L YLE KR++FPRF+
Sbjct: 1135 DKSWKEIMRKVNRLPNALRAATQPGLL-ETFQNNNALLDQIQKCLEAYLESKRVIFPRFY 1193
Query: 1585 FVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHA----------------KDYDR- 1627
F+S+ LLEIL Q + +QPHL D+I+++ F K Y
Sbjct: 1194 FLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPAEGKIPGIDGEPEKVYTND 1253
Query: 1628 IMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLP- 1686
I+A++S EGE++ L + A+G VE WL + + +SL + ++A I+D +L
Sbjct: 1254 ILAMLSPEGERVSLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAA---IADYQGKLRTD 1310
Query: 1687 -FLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDI--LNTLISQTTHD 1743
++ P+QV L Q++W D E L + I + N + ++ LN L +
Sbjct: 1311 WVVAGHPSQVILTVSQIMWCRDLTECLETEHSNH-IQALKNFEKVNFERLNALAAIVQGS 1369
Query: 1744 LSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITD 1803
L K R LITI VH RDI +LV+ +++ F+W +Q R+Y+ DLD V +
Sbjct: 1370 LPKLHRNILTALITIDVHARDIVTELVQSKVETVESFDWQRQLRYYWDIDLDNCVARMAL 1429
Query: 1804 VDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCL 1863
+ Y E+LG RLVITPLTDRCY+ L AL +++GGAPAGPAGTGKTETTKD+ + L
Sbjct: 1430 SQYTYGYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKAL 1489
Query: 1864 GKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARK 1923
VVFNCSD +D++ +GR F GLAQSG+W CFDEFNRI++ VLSV AQQ+ + A+
Sbjct: 1490 AIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKA 1549
Query: 1924 ERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRV 1983
+ +F+F +G + L F+TMNPGYAGR ELP+NLK FR AMMVP+ +I V
Sbjct: 1550 AKLSRFMF-EGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEV 1608
Query: 1984 KLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSE 2043
L S GF + ILA+K +YKLC EQL++Q HYDFG+R + SVL GS KR P+ +E
Sbjct: 1609 ILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLNE 1668
Query: 2044 LSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLIN 2103
+++R L+D NL K + +D LF +I+DLFPG+Q+ + Y LQ+ + + + L
Sbjct: 1669 DVVLIRALQDSNLPKFLTDDALLFSGIISDLFPGVQIPEHDYGILQSTIVDVMNRQNLQP 1728
Query: 2104 HPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKA---------QTECGRPHRE 2154
K++Q YET LVRHG+M +GP+G GKTTV IL + + + +
Sbjct: 1729 EMCMVRKVIQFYETMLVRHGVMLVGPTGGGKTTVYRILAETLGNLQKLGIENSFYQAVKT 1788
Query: 2155 MRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIEN 2214
+NPK+IT +++G ++ T +W DG+ + R + ++ ++I DGPVDA+WIEN
Sbjct: 1789 YVLNPKSITMGELYGEVNNLTLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIEN 1848
Query: 2215 LNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPI 2274
+N+VLDDNK L LAN +RI + P +LFEV ++ ASPATVSR GMV++ L W P
Sbjct: 1849 MNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLRVASPATVSRCGMVFVDPEELKWMPY 1908
Query: 2275 LQAWLK----KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEG 2330
++ W+K K T + L L+++ ++ ++ + + ++ + + LLE
Sbjct: 1909 VKTWMKGISKKLTEETQEYILNLFQRYVDEGLHFINKKCSQAIPQVDISKVTTLCCLLES 1968
Query: 2331 LIPSKEEGGVSCVEHLHKL-------FVFGLMWSLGALLELESREKLEAFLRQHESKLDL 2383
LI K+ GV+ KL FVF +WSLG L + + F+R D
Sbjct: 1969 LILGKD--GVNLAMEQTKLNTILCQTFVFCYLWSLGGNLTENYYDSFDTFIRTQFD--DN 2024
Query: 2384 PEIPKGSNQTMYEFYVT-DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLI 2442
P+ ++ ++ ++ D + W + + + Y D +P + +LVP D +R +L+
Sbjct: 2025 PDARLPNSGDLWSIHMDFDTKRLDPWERIIPTFKYNRD-VP-FFEMLVPTTDTVRYGYLM 2082
Query: 2443 DTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEV-QLSKSLNFSSATEPMMFQRTIESY 2501
+ + +VL TG G K+V+ K L K + LNFS+ T Q IES
Sbjct: 2083 EKLLAVKHSVLFTGITGVGKSVIAKGLLNKIQESAGYVPVYLNFSAQTSSARTQEIIESK 2142
Query: 2502 VDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFT 2561
++++ + G PG +++ +F+DD+NMP ++ +G Q E++RQ + G Y +K +
Sbjct: 2143 LERKRKNILGAPGNKRIVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLF-WK 2201
Query: 2562 TIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSF 2621
I DV +I+A PGGGRN + R R F++ +PS S+ +IF I G+ F
Sbjct: 2202 EIQDVTIISACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLS---DF 2258
Query: 2622 KPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASI 2681
P + + ++V ++ V +LPTP+K HY+FNLRDLS+ QG+L
Sbjct: 2259 PPAVKQTASSIVEASVEIYNKMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREE 2318
Query: 2682 PTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLRE 2741
+ LF HEC RV DR I ED+ +F+ LT ++ G + YF++
Sbjct: 2319 IQIFRLFCHECQRVFHDRLINNEDKHYFHVILTEMANKHFG-----IAIDLEYFLN---- 2369
Query: 2742 MPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTH 2801
P GD + + +IY+ MP + A LQ Y +N + + LVFF+DA+ H
Sbjct: 2370 KPIIFGDFIKFGADKADRIYDDMPDIEKTANVLQDYLDDYN-LTNPKEVKLVFFQDAIEH 2428
Query: 2802 LIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKA 2861
+ +I+R+IR GNALLVGVGG+GKQSL+RLA+ I GY+ QI L+R YN + +DL+
Sbjct: 2429 VSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYKCLQIELSRGYNYDSFHEDLRK 2488
Query: 2862 LYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMK 2921
LYK+AG + K + F+FTD++I E FLE +NN+L+SGE+ NLF +DE++++ K
Sbjct: 2489 LYKMAGVEDKNMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEQVLAATRPRAK 2548
Query: 2922 RELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRW 2981
E+ D +++YFIS+ R+ LH+VLC SPVGE FR+R FP L++ CT+DWF +W
Sbjct: 2549 -EVGISEGNRDEVFQYFISKVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQW 2607
Query: 2982 PREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKS 3041
PREAL++V+ F S + + E+K ++ H VS E Y+ RRR + TP S
Sbjct: 2608 PREALLSVSKTFFSQVD-AGNEELKEKLPLMCVNVHLSVSSMAERYYNELRRRYYTTPTS 2666
Query: 3042 YLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIK 3101
YL IN Y ++ +EK K I +R+ GL KL+E + V K+ DL+ E L S
Sbjct: 2667 YLELINLYLSMLSEKRKQIISARDRVKNGLTKLLETNILVDKMKLDLSALEPVLLAKSED 2726
Query: 3102 ADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAA 3161
+ ++ ++ V +++ +++N VQE + A+ +E + A+ L+ A PAL+ A A
Sbjct: 2727 VEALMEKLAVDQESADQVRNTVQEDEATAKVKAEETQAIADDAQRDLDEALPALDAANKA 2786
Query: 3162 LNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLM 3221
L+++ DI+ +R KPP L+M +M+ + +L KP W + +L+
Sbjct: 2787 LDSLDKADISEIRVFTKPPDLVMTVMEAISILLN--------------AKPDWPSAKQLL 2832
Query: 3222 SATGFLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFY 3281
+ FL L ++ K+ I + + LQ Y N D+ E +KV + W AM ++
Sbjct: 2833 GDSNFLKRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYS 2892
Query: 3282 GINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLN 3341
+ + V P + L + L + A L + QALL + + ++ +Q ++D +NEK L
Sbjct: 2893 RVVKVVEPKRQKLRAAQAELDITMATLREKQALLRQVEDQIQALQDEYDKGVNEKESLAK 2952
Query: 3342 DADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQI 3401
+ ++ A L L E++RW + ++F+ +I+ + G++ + ++Y G F
Sbjct: 2953 TMALTKARLVRAGKLTAALEDEQVRWEESIQKFEEEISNITGNVFIAAACVAYYGAFTAQ 3012
Query: 3402 FRNYLLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTK 3461
+R L+ + W + ++ +IP + +LI++L DP I +W GLP D +S +NGI+VT+
Sbjct: 3013 YRQSLI-ECWIQDCQSLEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLISTENGILVTQ 3071
Query: 3462 ATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEEL 3521
R+PL+IDPQ Q WI++KE ++ L++ L F LE+S+ LG P+L+E++ E L
Sbjct: 3072 GRRWPLMIDPQDQANRWIRNKESKSGLKIIKLTDSNFLRILENSIRLGLPVLLEELKETL 3131
Query: 3522 DPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDF 3581
DPAL+ +L K SG +++GD + D F+ Y+TTK+PNP + PE+ K ++I+F
Sbjct: 3132 DPALEPILLKQIFISGGRLLIRLGDSDIDYDKNFRFYMTTKMPNPHYLPEVCIKVTIINF 3191
Query: 3582 TVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLV 3641
TVT GLE+QLL V+ EK LE +R+KL+ + +K ++K +E+ +L L ++G+++
Sbjct: 3192 TVTKSGLEDQLLSDVVRLEKPRLEEQRIKLIVRINTDKNQLKTIEEKILRMLFTSEGNIL 3251
Query: 3642 DDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMV 3701
D+E LI L+ +K T+ + +L A TE IN A+E++RP AT+GS++YF+I +S +
Sbjct: 3252 DNEELIDTLQDSKITSGAIKTRLEEAESTEQMINVAREKYRPVATQGSVMYFVIASLSEI 3311
Query: 3702 NIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFV 3761
+ MYQ SL F +LF+ ++ S K+ Q+R+ ++E + RGL+E HK ++
Sbjct: 3312 DPMYQYSLKYFKQLFNTTIETSVKTENLQQRLDVLLEQTLLTAYVNVSRGLFEQHKLIYS 3371
Query: 3762 LLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYR-WILDMTWLNLVELSK-LPQ 3819
++ +++ Q+GT+ E+ ++G A L+ K PPKP W+ TW +L + P
Sbjct: 3372 FMLCVEMMRQQGTLSDAEWNFFLRGSAGLE-KERPPKPEAPWLPTATWFACCDLEESFPV 3430
Query: 3820 FAEIMNQISR--------------NEKGWKSWF-----DKDAPEEE--IIPDGYNDSLDT 3858
F + I N + W+ + DK +E+ D ++ L +
Sbjct: 3431 FHGLTQNILSHPISIRLGSFETYINPQKWEGYSKMKHEDKHMRQEKEAAHQDPWSAGLSS 3490
Query: 3859 CHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGS 3918
HKL+LI+ ++ VF ++ ++L +++ E ++L +++ TPL+ LS GS
Sbjct: 3491 FHKLILIKCCKEEKVVFALTDFVIENLGKQFIETPPVDLPTLYQDMSCNTPLVFILSTGS 3550
Query: 3919 DPTNQIDALAKK--LKLECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEF--- 3973
DP A++ ++IS+GQGQ A K+++ +M+ G WV LQNCHL + +
Sbjct: 3551 DPMGAFQRFARESGYSERVQSISLGQGQGPIAEKMVKDAMKSGNWVFLQNCHLAVSWMLA 3610
Query: 3974 MEELLETLITTE-ASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRTFAG 4032
MEEL++T + A D+FR+++++ P + FP+T+LQ S+K TNEPP+G+RA ++R F
Sbjct: 3611 MEELIKTFTDPDSAIKDTFRLFLSSMPSNTFPVTVLQNSVKVTNEPPKGLRANIRRAFTE 3670
Query: 4033 INQDLLDISNL-PMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQN 4091
+ + + L W+ +++ + F H+ +QER+KFGPLGWNI YEFN +D ++ ++
Sbjct: 3671 MTPSFFEENILGKKWRQIIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLKL 3730
Query: 4092 HLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTG 4151
+ E I W+ + Y+ GE+ YGGRVTD +D+R L + +FS + E + +
Sbjct: 3731 YCKEGKI----PWDALIYITGEITYGGRVTDSWDQRCLRTILKRFFSPETLEEDYKYSES 3786
Query: 4152 --YKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKES 4209
Y P+ +L ++ +YI++LP +D+PE+FG+H NA++ +Q S ++ TI +QP+ S
Sbjct: 3787 GIYFAPMADSLQEFKDYIENLPLIDDPEIFGMHENANLVFQYKETSTLINTILEVQPRSS 3846
Query: 4210 GGGVGETREAIVYRLSEDMLSKLPPDY-IPHEVKSRLIK--MGHLNSMNIFLRQEIDRMQ 4266
GG G++ + IV L + +++P + +S +K G LNS+ L QE+DR
Sbjct: 3847 TGGEGKSNDEIVQELVASVQTRVPEKLEMEGASESLFVKDLQGRLNSLTTVLGQEVDRFN 3906
Query: 4267 RVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDS-STLGFWFTE 4325
++ ++ +SL L AI G ++MSE + ++ + ++P LW ++ S LG W +
Sbjct: 3907 NLLKLIHTSLETLNKAIAGFVVMSEEMEKVYNSFLNNQVPALWSNTAYPSLKPLGSWVKD 3966
Query: 4326 LLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQ 4385
L+ R + W+ G+P +W++GFF PQGFLT Q R + +D ++ V+
Sbjct: 3967 LILRTSFVDLWLKRGQPKSYWISGFFFPQGFLTGTLQNHARKY-NLPIDELSFKYSVIPT 4025
Query: 4386 TKEEIT--------------------SPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVL 4425
+++ P +GV ++G++MD + WD + + ++ P +
Sbjct: 4026 YRDQAAVIEAAKTVQFGQELPMDMELPSPEDGVLVHGMFMDASRWDDKEMVIEDALPGQM 4085
Query: 4426 FTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRT--------DLTFITVVYLRTVLSPDH 4477
LPV+H F P LY CP+YK R F+ V L + S D+
Sbjct: 4086 NPVLPVVH-FEPQQNYKPSPTLYHCPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDY 4144
Query: 4478 WILRGVALLCDI 4489
WI +G ALLC +
Sbjct: 4145 WIAKGSALLCQL 4156
>gi|114155133 dynein, axonemal, heavy chain 9 isoform 2 [Homo sapiens]
Length = 4486
Score = 1930 bits (5001), Expect = 0.0
Identities = 1170/3539 (33%), Positives = 1890/3539 (53%), Gaps = 118/3539 (3%)
Query: 1007 FQKYKTLWTEDRDVKVKEFLA--------------------NNPSLTEIRSEILHYATFE 1046
F +Y L+ EDR + +FL N P L++ + +I Y T
Sbjct: 1010 FSQYSYLYVEDRKEVLGQFLLYGHILTPEEIEDHVEDGIPENPPLLSQFKVQIDSYETLY 1069
Query: 1047 QEIDELKPIIVV-GALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEY 1105
+E+ L+PI V G +++ P K +L K W +L ++L + ++ + AFI +
Sbjct: 1070 EEVCRLEPIKVFDGWMKIDIRPFKASLLNIIKRWSLLFKQHLVDHVTHSLANLDAFIKKS 1129
Query: 1106 LKKLSRPIR--DLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESE 1163
L + + D + M L +++ + D P+++ +L +E E+ + +
Sbjct: 1130 ESGLLKKVEKGDFQGLVEIMGHLMAVKERQSNTDEMFEPLKQTIELLKTYEQELPETVFK 1189
Query: 1164 AVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPM-V 1222
++ L +N ++ A++V++ + +Q + L + F + F E + E P
Sbjct: 1190 QLEELPEKWNNIKKVAITVKQQVAPLQANEVTLLRQRCTAFDAEQQQFWEQFHKEAPFRF 1249
Query: 1223 PNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLY 1282
+I P + + I + + S LF + V DY+ L + RKE+ L++L+
Sbjct: 1250 DSIHPHQMLDARHI---EIQQMESTMASISESASLFEVNVPDYKQLRQCRKEVCQLKELW 1306
Query: 1283 GLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDF 1342
V SSI + W ++++E + E +F R L K ++ W AF L+ + +
Sbjct: 1307 DTIGMVTSSIHAWETTPWRNINVEAMELECKQFARHIRNLDKEVRAWDAFTGLESTVWNT 1366
Query: 1343 SESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICI 1402
S + + N A+++RHW ++ + TG F ++ D+ L ++++ L ++D++ I
Sbjct: 1367 LSSLRAVAELQNPAIRERHWRQLMQATGVSFTMDQDT-TLAHLLQLQLHHYEDEVRGIVD 1425
Query: 1403 SAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLL 1462
A KE +E L ++ W + LL E ++I ++ED+ + L +L+
Sbjct: 1426 KAAKEMGMEKTLKELQTTWAGMEFQYEPHPRTNVPLLCSDE--DLIEVLEDNQVQLQNLV 1483
Query: 1463 SNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGG-DIAKQLPQEAKRF 1521
++Y A F + + W KLST +I W VQ W +LE++F G DI QLPQ++KRF
Sbjct: 1484 MSKYVAFFLEEVSGWQKKLSTVDAVISIWFEVQRTWTHLESIFTGSEDIRAQLPQDSKRF 1543
Query: 1522 QNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFP 1581
+ ID + ++ A + PNV+ + + L + +L +C+K+L YL+ KRL FP
Sbjct: 1544 EGIDIDFKELAYDAQKIPNVVQT-TNKPGLYEKLEDIQGRLCLCEKALAEYLDTKRLAFP 1602
Query: 1582 RFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFH----AKDYDRIMAVISREGE 1637
RF+F+S LL+IL + +Q HL + DN+ ++ F + + + S+E E
Sbjct: 1603 RFYFLSSSDLLDILSNGTAPQQVQRHLSKLFDNMAKMRFQLDASGEPTKTSLGMYSKEEE 1662
Query: 1638 KIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGL 1697
+ G VEIWL +L +++ + + + + +L PAQV L
Sbjct: 1663 YVAFSEPCDCSGQVEIWLNHVLGHMKATVRHEMTEGVTAYEEKPRE--QWLFDHPAQVAL 1720
Query: 1698 LGIQMLWTHDSEEALRNAKDD-RKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLI 1756
Q+ WT + A ++ M+ +K + L TLI+ LSK DR K T+
Sbjct: 1721 TCTQIWWTTEVGMAFARLEEGYESAMKDYYKKQVAQLKTLITMLIGQLSKGDRQKIMTIC 1780
Query: 1757 TIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCT 1816
TI VH RD+ ++ + + F WL Q R + +++ +I D F+Y E+LG T
Sbjct: 1781 TIDVHARDVVAKMIAQKVDNAQAFLWLSQLRHRWDDEVKHCFANICDAQFLYSYEYLGNT 1840
Query: 1817 DRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQM 1876
RLVITPLTDRCYITL Q+L + M GAPAGPAGTGKTETTKD+GR LG V VFNCS+QM
Sbjct: 1841 PRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGILVYVFNCSEQM 1900
Query: 1877 DFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDC 1936
D++ G I+KGLAQ+G+WGCFDEFNRI + VLSV A Q+ + A +++K+ F F G+
Sbjct: 1901 DYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKSIQDAIRDKKQWFSFL-GEE 1959
Query: 1937 VDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVIL 1996
+ LNP GIF+TMNPGYAGR ELPENLK FR AM+VPD ++I + L + GF+E L
Sbjct: 1960 ISLNPSVGIFITMNPGYAGRTELPENLKSLFRPCAMVVPDFELICEIMLVAEGFIEAQSL 2019
Query: 1997 AQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNL 2056
A+KF LY+LC+E L+KQ HYD+GLR I SVL GS KR P+ E ++MR LRD N+
Sbjct: 2020 ARKFITLYQLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPDRPEDQVLMRSLRDFNI 2079
Query: 2057 SKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYE 2116
K+V +D P+F+ LI DLFP L + + V + L + LK+VQL E
Sbjct: 2080 PKIVTDDMPIFMGLIGDLFPALDVPRRRDPNFEALVRKAIVDLKLQAEDNFVLKVVQLEE 2139
Query: 2117 TSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATN 2176
VRH + +G +G+GK+ V+ L K R +NPKA+T ++FG ++ AT
Sbjct: 2140 LLAVRHSVFVVGGAGTGKSQVLRSLHKTYQIMKRRPVWTDLNPKAVTNDELFGIINPATG 2199
Query: 2177 DWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMA 2236
+W DG+FS++ R+ +++LDG +D +WIE+LN+V+DDNK LTLA+ +RIP+
Sbjct: 2200 EWKDGLFSSIMRELANITHDGPKWILLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLN 2259
Query: 2237 PSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLKKRTAQ-EAAVFLTLYE 2295
P+ KLLFE+ ++ A+PATVSR G++YI+ + L W P + +W++KR Q E A L++
Sbjct: 2260 PTMKLLFEISHLRTATPATVSRAGILYINPADLGWNPPVSSWIEKREIQTERANLTILFD 2319
Query: 2296 KVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHK-LFVFGL 2354
K ++ + + E + + +LLE L+ + E+ C + +++ FVF
Sbjct: 2320 KYLPTCLDTLRTRFKKIIPIPEQSMVQMVCHLLECLL-TTEDIPADCPKEIYEHYFVFAA 2378
Query: 2355 MWSL-GALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYV-TDYGDWEHWNKKL 2412
+W+ GA+++ + + F + ++ + P S T++++Y+ + +E W+K +
Sbjct: 2379 IWAFGGAMVQDQLVDYRAEFSKWWLTEFKTVKFP--SQGTIFDYYIDPETKKFEPWSKLV 2436
Query: 2413 QPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKK 2472
+ + D + LV + IR + ++ + + + V+L G GT K+V+V A L
Sbjct: 2437 PQFEF--DPEMPLQACLVHTSETIRVCYFMERLMARQRPVMLVGTAGTGKSVLVGAKLAS 2494
Query: 2473 YDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINE 2532
DPE L K++ F+ T M Q +E ++K+ G YGPPG +K+ FIDD+NMP ++
Sbjct: 2495 LDPEAYLVKNVPFNYYTTSAMLQAVLEKPLEKKAGRNYGPPGNKKLIYFIDDMNMPEVDA 2554
Query: 2533 WGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTV 2592
+G + I+RQ ++ Y K I +VQ ++ M +P G I RL+R F+V
Sbjct: 2555 YGTVQPHTIIRQHLDYGHWYDRSKL-SLKEITNVQYVSCM-NPTAGSFTINPRLQRHFSV 2612
Query: 2593 FNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPS 2652
F + P ++ I+ II + +F + + I L+ + Q LPT
Sbjct: 2613 FVLSFPGADALSSIYSIILTQHL-KLGNFPASLQKSIPPLIDLALAFHQKIATTFLPTGI 2671
Query: 2653 KFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAH 2712
KFHYIFNLRD + I+QG+L E S L+ L+ HE +RV D+ + +D F+
Sbjct: 2672 KFHYIFNLRDFANIFQGILFSSVECVKSTWDLIRLYLHESNRVYRDKMVEEKDFDLFDKI 2731
Query: 2713 LTRAVEENIG--SDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFL 2770
T +++ D + F + EP Y + S++ L
Sbjct: 2732 QTEVLKKTFDDIEDPVEQTQSPNLYCHFANGIGEPK--------------YMPVQSWELL 2777
Query: 2771 AEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLS 2830
+ L NE+ T +DLV F+DAM H+ I+RI+ + GNALLVGVGGSGKQSL+
Sbjct: 2778 TQTLVEALENHNEV--NTVMDLVLFEDAMRHVCHINRILESPRGNALLVGVGGSGKQSLT 2835
Query: 2831 RLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEY 2890
RLA+FI+ +FQITL + Y + + DL +L AG F+ TD+++ DE FL
Sbjct: 2836 RLAAFISSMDVFQITLRKGYQIQDFKMDLASLCLKAGVKNLNTVFLMTDAQVADERFLVL 2895
Query: 2891 LNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVL 2950
+N+LL+SGEI +L++ DE++ I + + +K + +N +++FI R R+ L V L
Sbjct: 2896 INDLLASGEIPDLYSDDEVENIISNVRNEVKSQ--GLVDNRENCWKFFIDRIRRQLKVTL 2953
Query: 2951 CFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVV 3010
CFSPVG K R RS KFP +++ + WF WP++AL +V+ FL + + +K+ +
Sbjct: 2954 CFSPVGNKLRVRSRKFPAIVNCTAIHWFHEWPQQALESVSLRFLQNTEGI-EPTVKQSIS 3012
Query: 3011 ETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIG 3070
+ M H V+++ +SY +R + TPKS+L FI Y+++ K + + ER+ G
Sbjct: 3013 KFMAFVHTSVNQTSQSYLSNEQRYNYTTPKSFLEFIRLYQSLLHRHRKELKCKTERLENG 3072
Query: 3071 LDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKA 3130
L KL S V L LA +E EL + AD+++ V V ++ K E + K
Sbjct: 3073 LLKLHSTSAQVDDLKAKLAAQEVELKQKNEDADKLIQVVGVETDKVSREKAMADEEEQKV 3132
Query: 3131 QKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCV 3190
I+ E+ ++ E L A+PAL A+AALNT+ ++ ++ PP + + V
Sbjct: 3133 AVIMLEVKQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAV 3192
Query: 3191 LLLFQKKIDPVTMDPEKSCCKP-SW-GESLKLMSATGFLWSLQQFPKDTINEETVELLQP 3248
++L M P K SW + + GFL SL F K+ I+E ++ ++P
Sbjct: 3193 MVL---------MAPRGRVPKDRSWKAAKVTMAKVDGFLDSLINFNKENIHENCLKAIRP 3243
Query: 3249 YFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAEL 3308
Y ++ E AGL SW + + FY + +V P + L K L A +L
Sbjct: 3244 YLQDPEFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATADLTAAQEKL 3303
Query: 3309 GKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWT 3368
+A + L K+ A+F+ A +K+ +A+ + A+ L+ GL+ E +RW
Sbjct: 3304 AAIKAKIAHLNENLAKLTARFEKATADKLKCQQEAEVTAVTISLANRLVGGLASENVRWA 3363
Query: 3369 QQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARK--IPFTENL 3426
+ FK Q L GDILL T F+SYLG F + +R LL W L K IP T L
Sbjct: 3364 DAVQNFKQQERTLCGDILLITAFISYLGFFTKKYRQSLLDRTWRPYLSQLKTPIPVTPAL 3423
Query: 3427 NLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKEN 3486
+ + ML+D + W +GLP D +S++N I+ R+PL++DPQ QG WIK+K E
Sbjct: 3424 DPLRMLMDDADVAAWQNEGLPADRMSVENATILINCERWPLMVDPQLQGIKWIKNKYGE- 3482
Query: 3487 DLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGD 3546
DL+VT + K + +E +L G +LIE++ E +DP L +L + IK G +K+GD
Sbjct: 3483 DLRVTQIGQKGYLQIIEQALEAGAVVLIENLEESIDPVLGPLLGREVIKKGRF--IKIGD 3540
Query: 3547 KECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEA 3606
KEC+ F+L + TKL NP + PE+ A+ ++I+FTVT GLE+QLL V+ E+ +LE
Sbjct: 3541 KECEYNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVSMERPDLEQ 3600
Query: 3607 ERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHV 3666
+ L + K +K LED+LL +LS+ G+ + + L+ L TKQTAAEV +K+
Sbjct: 3601 LKSDLTKQQNGFKITLKTLEDSLLSRLSSASGNFLGETVLVENLEITKQTAAEVEKKVQE 3660
Query: 3667 AAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKS 3726
A TE+KIN A+E +RPAA R S+LYF++ ++S ++ MYQ SL F +F +++ R+
Sbjct: 3661 AKVTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVERAAPD 3720
Query: 3727 PLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKG 3786
++R+ N+I+ +T+ V+ Y++RGL+E K ++ +T +I L V E L++
Sbjct: 3721 ESLRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAVELDFLLRS 3780
Query: 3787 GAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEE 3846
++ P ++ W + LS + +F+ + I + K WK + + + PE+E
Sbjct: 3781 ----PVQTGTASPVEFLSHQAWGAVKVLSSMEEFSNLDRDIEGSAKSWKKFVESECPEKE 3836
Query: 3847 IIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDT 3906
+P + + +L ++R+ PDR + R ++ + L KY L+ ++EES
Sbjct: 3837 KLPQEWKNK-TALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGP 3895
Query: 3907 RTPLICFLSMGSDPTNQIDALAKKL-----KLECRTISMGQGQEVHARKLIQMSMQQGGW 3961
TP+ LS G DP +++ +KL +S+GQGQEV A + ++ ++G W
Sbjct: 3896 ATPMFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHW 3955
Query: 3962 VLLQNCHLGLEFMEELLETLIT-TEASDDSFRVWITTEPHDR-----FPITLLQTSLKFT 4015
V+LQN HL +++ L + L +E S FRV+++ EP P +L+ S+K T
Sbjct: 3956 VILQNIHLVAKWLSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKIT 4015
Query: 4016 NEPPQGVRAGLKRTFAGINQDLLDI-SNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIP 4074
NEPP G+ A L + QD L++ S +K +L+ + + H+ V ERRKFGP GWN
Sbjct: 4016 NEPPTGMHANLHKALDNFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRS 4075
Query: 4075 YEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFAR 4134
Y FN+ D + SV + N L E + K V ++ +RY+ GE+ YGG +TDD+D+RL +
Sbjct: 4076 YPFNTGDLTISVNVLYNFL-EANAK--VPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLG 4132
Query: 4135 VWFSEKMFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTA 4194
+ +M E G+ +P + Y +YI + ++P ++GLHPNA+I + + T+
Sbjct: 4133 EFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTS 4192
Query: 4195 SAVLETITNIQPKESGG--GVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLN 4252
+ T+ +QP++S G G TRE V L E++L ++ ++ + + K+
Sbjct: 4193 EKLFRTVLELQPRDSQARDGAGATREEKVKALLEEILERVTDEF---NIPELMAKVEERT 4249
Query: 4253 SMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRV 4312
+ QE RM + ++ SL +L+L ++G + M+ ++ + + +Y +P+ W R
Sbjct: 4250 PYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARR 4309
Query: 4313 SWDSST-LGFWFTELLERNAQFSTWIFE-GRPNVFWMTGFFNPQGFLTAMRQEVTRAHKG 4370
++ S+ L WF +LL R + W + P+ W+TGFFNPQ FLTA+ Q R ++
Sbjct: 4310 AYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNE- 4368
Query: 4371 WALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLP 4430
W LD + + ++ ++ +EE SPP EG YI+GL+M+GA WD + G + E+ K L +P
Sbjct: 4369 WPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMP 4428
Query: 4431 VLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDI 4489
V+ I AI + +Y CP+YK +R T++ L+T +P W+L GVALL I
Sbjct: 4429 VMFIKAIPADKQDCRSVYSCPVYKTSQRGP-TYVWTFNLKTKENPSKWVLAGVALLLQI 4486
Score = 167 bits (423), Expect = 2e-40
Identities = 154/753 (20%), Positives = 330/753 (43%), Gaps = 46/753 (6%)
Query: 58 LANIFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDN 117
LA +F VL L K + H+ E + R+ L I VK KT+
Sbjct: 133 LAALFSEVVLPV-----LANEKNRLNWPHMICEDVRRHAHSLQCDLSVILEQVKGKTLLP 187
Query: 118 VNFSKLHTFEEVTAAASNSETV---------HQLEEVLMVWYKQIEQVLI-ESEQMRKEA 167
+ E++ A S SETV + +E ++ W Q++ VL ES Q +
Sbjct: 188 LPAGS----EKMEFADSKSETVLDSIDKSVIYAIESAVIKWSYQVQVVLKRESSQPLLQG 243
Query: 168 GDSGPLTELEHWKRMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTA 227
+ P ELE WK YI Q++ + + + +L+ S ++ + +
Sbjct: 244 ENPTPKVELEFWKSRYEDLKYIYNQLRTITVRGMAKLLDKLQSSYFPAFKAMYRDVVAAL 303
Query: 228 NESKDNVRYLYTLEKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFI 287
E++D +L L++ + L N + + ++ L++ + +I + Y + R+T L
Sbjct: 304 AEAQDIHVHLIPLQRHLEALENAEFPEVKPQLRPLLHVVCLIWATCKSYRSPGRLTVLLQ 363
Query: 288 KVTNQMVTACKAYITDGGLNHVWDQETPVVLKKIQDCIFLFK-EYQASFHKTRKLISESS 346
++ N ++ Y++ L +E+ L+ + D + FK E+Q E+
Sbjct: 364 EICNLLIQQASNYLSPEDLLRSEVEESQRKLQVVSDTLSFFKQEFQDRRENLHTYFKENQ 423
Query: 347 GEKSFEVSEMYIFGKFEAFCKRLEKITEMITVVQTYSTL---------SNSTIEGIDIMA 397
K ++ +F + + F +L + ++ + L N+ + + M
Sbjct: 424 EVKEWDFQSSLVFVRLDGFLGQLHVVEGLLKTALDFHKLGKVEFSGVRGNALSQQVQQMH 483
Query: 398 IKFRNIYQGVKKKQYDILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQA 457
+F+ +Y+ + D L + T+F+ D +F K+ L+ ++ +F + A
Sbjct: 484 EEFQEMYRLLSGSSSDCLYLQSTDFENDVSEFNQKVEDLDRRLGTIFIQAFDDAPGLEHA 543
Query: 458 LQLLQ-RFQKLNIPCLGLEINHTIERILQYYVAELDATKKLY--HSQKDD----PPLARN 510
+LL L P + + + ++Q + +LDA + +Y H Q++ P+ +N
Sbjct: 544 FKLLDIAGNLLERPLVARDTSDKYLVLIQMFNKDLDAVRMIYSQHVQEEAELGFSPVHKN 603
Query: 511 MPPIAGKILWVRQLYRRISEPINYFFK-NSDILSSPDGKAVIRQYNKISYVLVEFEVVYH 569
MP +AG + W ++L +RI P + F + + S +GK + ++Y + +L ++E +
Sbjct: 604 MPTVAGGLRWAQELRQRIQGPFSNFGRITHPCMESAEGKRMQQKYEDMLSLLEKYETRLY 663
Query: 570 TAWIREISQ-LHYALQATLFVRHPETGKLLVNFDPKILEVVRETKCMIKMKL-DVPEQAK 627
W R +S+ Y L L R PET ++ +NF+P+++ V++E + ++ +PE A
Sbjct: 664 EDWCRTVSEKSQYNLSQPLLKRDPETKEITINFNPQLISVLKEMSYLEPREMKHMPETAA 723
Query: 628 RLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSS 687
+ + L+ + +Y+++ + + V L+ +++ ++ LR L W +
Sbjct: 724 AMFSSRDFYRQLVANLELMANWYNKVMKTLLEVEFPLVEEELQNIDLRLRAAEETLNWKT 783
Query: 688 LTLESFFQEVELVLDMFNQLLKKISDLCEMHIDTVLKEIAKTVLISLPESGATKVEDMLT 747
+ + E+ + Q ++K D E ++ I KT + + ++ K E +L+
Sbjct: 784 EGICDYVTEITSSIHDLEQRIQKTKDNVE-----EIQNIMKTWVTPIFKTKDGKRESLLS 838
Query: 748 LNETYTK--EWADILNHKSKHVEEAVRELISIF 778
L++ + + ++ +++ + V+E + +F
Sbjct: 839 LDDRHDRMEKYYNLIKESGLKIHALVQENLGLF 871
>gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4470
Score = 1926 bits (4989), Expect = 0.0
Identities = 1180/3583 (32%), Positives = 1910/3583 (53%), Gaps = 126/3583 (3%)
Query: 966 ARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEF 1025
A+ N+ + ++ D+ ++ +SS V + K A E F++Y LWT++ +K F
Sbjct: 955 AKDRMNYKMDLEDNTDLIEMREEVSSLVINAMKEAEEYQDSFERYSYLWTDNLQEFMKNF 1014
Query: 1026 LANN--------------------PSLTEIRSEILHYATFEQEIDELKPIIVV-GALELH 1064
L P+L + + +I Y +E+ + + V G L+
Sbjct: 1015 LIYGCAVTAEDLDTWTDDTIPKTPPTLAQFQEQIDSYEKLYEEVSKCENTKVFHGWLQCD 1074
Query: 1065 TEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIR--DLDDVRFA 1122
P K AL + W + R+L+ ++ + AF+ L++P++ D D +
Sbjct: 1075 CRPFKQALLSTIRRWGFMFKRHLSNHVTNSLADLEAFMKVARMGLTKPLKEGDYDGLVEV 1134
Query: 1123 MEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSV 1182
M L +++ + D P+++ +L + E+ +E + L + + A+ V
Sbjct: 1135 MGHLMKVKERQAATDNMFEPLKQTIELLKTYGEEMPEEIHLKLQELPEHWANTKKLAIQV 1194
Query: 1183 QEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIP-PQEASNRLQIFQASF 1241
+ + +Q S L + F F E + E P + P P ++ N+ Q ++
Sbjct: 1195 KLTVAPLQANEVSILRRKCQQFELKQHEFRERFRREAPFSFSDPNPYKSLNKQQKSISAM 1254
Query: 1242 DDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWG 1301
+ + S LF +PV DY+ L +E+ LL++L+ + V +SI + W
Sbjct: 1255 EGIMEAL---SKSGGLFEVPVPDYKQLKACHREVRLLKELWDMVVVVNTSIEDWKTTKWK 1311
Query: 1302 DVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRH 1361
D+++E+++ + +F R L K +K W AF+ L + + S + + N A+++RH
Sbjct: 1312 DINVEQMDIDCKKFAKDMRSLDKEMKTWDAFVGLDNTVKNVITSLRAVSELQNPAIRERH 1371
Query: 1362 WDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENW 1421
W ++ + T F + S+ L ++++ L ++D++ +I A+KE +E L + W
Sbjct: 1372 WQQLMQATQVKFKM-SEETTLADLLQLNLHSYEDEVRNIVDKAVKESGMEKVLKALDSTW 1430
Query: 1422 TNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKL 1481
+ G ++LK +E ++ +ED+ + L +L+ ++Y A F K + +W KL
Sbjct: 1431 SMMEFQHEPHPRTGTMMLKSSEV--LVETLEDNQVQLQNLMMSKYLAHFLKEVTSWQQKL 1488
Query: 1482 STSSDIIEEWLVVQNLWVYLEAVFVGG-DIAKQLPQEAKRFQNIDKSWIKIMQRAHENPN 1540
ST+ +I W VQ W +LE++F+G DI QLP +++RF +I++ + +M+ A + PN
Sbjct: 1489 STADSVISIWFEVQRTWSHLESIFIGSEDIRTQLPGDSQRFDDINQEFKALMEDAVKTPN 1548
Query: 1541 VINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASD 1600
V+ + L L + L +C+K+L YLE KRL FPRF+FVS LL+IL +D
Sbjct: 1549 VVEA-TSKPGLYNKLEALKKSLAICEKALAEYLETKRLAFPRFYFVSSADLLDILSNGND 1607
Query: 1601 SHTIQPHLPAVSDNINEVTFHAKDYDRIMAV----ISREGEKIVLDNSVMAKGPVEIWLL 1656
+ HL + D++ ++ F D+ + V S+E E +V D G VE+WL
Sbjct: 1608 PVEVSRHLSKLFDSLCKLKFRLDASDKPLKVGLGMYSKEDEYMVFDQECDLSGQVEVWLN 1667
Query: 1657 DLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAK 1716
+L S+L + I A + + ++ +PAQV L Q+ WT + A +
Sbjct: 1668 RVLDRMCSTLRHEIPEAVVTYEEKPRE--QWILDYPAQVALTCTQIWWTTEVGLAFARLE 1725
Query: 1717 DD-RKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIK 1775
+ ++ N+K + LN LI+ +L+ DR+K T+ TI VH RD+ ++ ++
Sbjct: 1726 EGYENAIRDYNKKQISQLNVLITLLMGNLNAGDRMKIMTICTIDVHARDVVAKMIVAKVE 1785
Query: 1776 SPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQA 1835
S F W Q R + E+ +I D Y E+LG T RLVITPLTDRCYITL Q+
Sbjct: 1786 SSQAFTWQAQLRHRWDEEKRHCFANICDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQS 1845
Query: 1836 LGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWG 1895
L + MGGAPAGPAGTGKTETTKD+GR LG V VFNCS+QMD++ G I+KGLAQ+G+WG
Sbjct: 1846 LHLIMGGAPAGPAGTGKTETTKDLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWG 1905
Query: 1896 CFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAG 1955
CFDEFNRI + VLSV A Q+ V A + +KK F F G+ + L P GIF+TMNPGYAG
Sbjct: 1906 CFDEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFL-GEIIGLIPTVGIFITMNPGYAG 1964
Query: 1956 RQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQV 2015
R ELPENLK FR AM+VPD ++I + L + GFLE +LA+KF LY LC+E L+KQ
Sbjct: 1965 RAELPENLKALFRPCAMVVPDFELICEIMLMAEGFLEARLLARKFITLYTLCKELLSKQD 2024
Query: 2016 HYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLF 2075
HYD+GLR I SVL GS KR P +E ++MR LRD N+ K+V +D P+F+ LI DLF
Sbjct: 2025 HYDWGLRAIKSVLVVAGSLKRGDPSRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLF 2084
Query: 2076 PGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKT 2135
P L + + + + L + LK+VQL E VRH + +G +GSGK+
Sbjct: 2085 PALDVPRKRDLNFEKIIKQSIVELKLQAEDSFVLKVVQLEELLQVRHSVFIVGNAGSGKS 2144
Query: 2136 TVITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKK 2195
V+ L K R + ++PKA+T ++FG ++ T +W DG+FST+ R
Sbjct: 2145 QVLKSLNKTYQNLKRKPVAVDLDPKAVTCDELFGIINPVTREWKDGLFSTIMRDLANITH 2204
Query: 2196 GENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPAT 2255
++ILDG +D +WIE+LN+V+DDNK LTLA+ +RIP+ + +L+FE+ ++ A+PAT
Sbjct: 2205 DGPKWIILDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPAT 2264
Query: 2256 VSRMGMVYISSSALSWRPILQAWLKKRTAQ-EAAVFLTLYEKVFEDTYTYMKLNLNPKMQ 2314
VSR G++YI+ + L W P++ +W+++R Q E A + L++K ++
Sbjct: 2265 VSRAGILYINPADLGWNPVVSSWIERRKVQSEKANLMILFDKYLPTCLDKLRFGFKKITP 2324
Query: 2315 LLECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSL-GALLELESREKLEAF 2373
+ E I L LLE L+ K S E FVF W+ GA+ + + + F
Sbjct: 2325 VPEITVIQTILYLLECLLTEKTVPPDSPRELYELYFVFTCFWAFGGAMFQDQLVDYRVEF 2384
Query: 2374 LRQHESKLDLPEIPKGSNQTMYEFYV-TDYGDWEHWNKKLQPYYYPTDSIPEYSSILVPN 2432
+ ++ + P S T++++Y+ D + W K+ + D +P +S LV
Sbjct: 2385 SKWWINEFKTIKFP--SQGTIFDYYIDPDTKKFLPWTDKVPSFELDPD-VPLQAS-LVHT 2440
Query: 2433 VDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPM 2492
+ IR + +D + ++ V+L G GT K+V++ L+ + + L +++ F+ T
Sbjct: 2441 TETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKLESLNTDNYLVQAVPFNFYTTSA 2500
Query: 2493 MFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMY 2552
M Q +E ++K+ G YGPPG +K+ FIDD+NMP ++++G + ++RQ M+ Y
Sbjct: 2501 MLQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAPHTLIRQHMDHRHWY 2560
Query: 2553 SLDKPGDFTTIVDV---QLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGI 2609
K T+ D+ Q +A M +P G I RL+R F VF + P ++ I+
Sbjct: 2561 DRHK----LTLKDIHNCQYVACM-NPTSGSFTIDSRLQRHFCVFAVSFPGQEALTTIYNT 2615
Query: 2610 IGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQG 2669
I + RS I + LV+ L Q LPT KFHY+FNLRDLS I+QG
Sbjct: 2616 ILTQHL-AFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLRDLSNIFQG 2674
Query: 2670 MLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCI 2729
+L AE + L+ L+ HE RV D+ + +D++ + +T A + D +
Sbjct: 2675 LLFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLH-RVTMASTKKFFDDLGDEL 2733
Query: 2730 L--PEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRG 2787
L F F + + +P + + ++ P L + L Y NE+
Sbjct: 2734 LFAKPNIFCHFAQGIGDP----------KYVPVTDMAPLNKLLVDVLDSY----NEV--N 2777
Query: 2788 TSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLT 2847
++LV F+DA+ H+ +I+RI+ + GNALLVGVGGSGKQSLSRLA++I+G +FQITL
Sbjct: 2778 AVMNLVLFEDAVAHICRINRILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLK 2837
Query: 2848 RSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARD 2907
+ Y + +L DL A Y A F+ TDS++ +E FL +N+LL+SGEI LF D
Sbjct: 2838 KGYGIPDLKIDLAAQYIKAAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMED 2897
Query: 2908 EMDEITQGLISVMKRELPR--HPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLK 2965
E++ I IS M+ ++ T + +++FI + R+ L V+LCFSPVG R R+ K
Sbjct: 2898 EVENI----ISSMRPQVKSLGMNDTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARK 2953
Query: 2966 FPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCE 3025
FP +++ +DWF WP +AL++V++ FL + + IK + M H V+E
Sbjct: 2954 FPAVVNCTAIDWFHEWPEDALVSVSARFLEETEGI--PVIKASISFFMSYVHTTVNEMSR 3011
Query: 3026 SYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLS 3085
Y RR + TPK++L I Y+N+ A+K + + ER+ GL KL + V L
Sbjct: 3012 VYLATERRYNYTTPKTFLEQIKLYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLK 3071
Query: 3086 QDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAE 3145
LA++E EL + AD+++ V + A+ +K K + + K + I + ++ E
Sbjct: 3072 AKLAIQEAELKQKNESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACE 3131
Query: 3146 SKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDP 3205
+ L A+PAL A+ AL+T+ N++ ++ PP ++ + V++L T
Sbjct: 3132 TDLAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMIL--------TAPG 3183
Query: 3206 EKSCCKPSWGESLKLMSATG-FLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVC 3264
K SW + +M FL SL++F K+ I E ++ +PY + E +
Sbjct: 3184 GKIPKDKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKS 3243
Query: 3265 GNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDK 3324
AGL SW + + FY + +V P + L + LA A +L + + + E A L
Sbjct: 3244 TAAAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSN 3303
Query: 3325 VQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGD 3384
+ + F+ A EK+ +AD + + A+ L+ GL+ E IRW + + F++Q L GD
Sbjct: 3304 LTSAFEKATAEKIKCQQEADATNRVILLANRLVGGLASENIRWAESVENFRSQGVTLCGD 3363
Query: 3385 ILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARK--IPFTENLNLISMLVDPPTIGEWG 3442
+LL + F+SY+G F + +RN L++ W + K IP T L+ +S+L D + W
Sbjct: 3364 VLLISAFVSYVGYFTKKYRNELMEKFWIPYIHNLKVPIPITNGLDPLSLLTDDADVATWN 3423
Query: 3443 LQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHL 3502
QGLP D +S +N I+ R+PL++D Q QG WIK+K + ++L+ L K + +
Sbjct: 3424 NQGLPSDRMSTENATILGNTERWPLIVDAQLQGIKWIKNKYR-SELKAIRLGQKSYLDVI 3482
Query: 3503 EDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTK 3562
E ++S G LLIE+I E +DP LD +L +N IK G +K+GDKE + F+L + TK
Sbjct: 3483 EQAISEGDTLLIENIGETVDPVLDPLLGRNTIKKGK--YIKIGDKEVEYHPKFRLILHTK 3540
Query: 3563 LPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKM 3622
NP + PE+ A+ ++I+F VT GLE+QLL V+ E+ +LE + L + K +
Sbjct: 3541 YFNPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVL 3600
Query: 3623 KELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFR 3682
KELED+LL +LSA G+ + D +L+ L TTK TA+E+ EK+ A TE+KIN A+E +R
Sbjct: 3601 KELEDSLLARLSAASGNFLGDTALVENLETTKHTASEIEEKVVEAKITEVKINEARENYR 3660
Query: 3683 PAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTY 3742
PAA R S+LYF++ +++ +N +YQ SL F +F++++ R+ + ++R+ N+ + +TY
Sbjct: 3661 PAAERASLLYFILNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITY 3720
Query: 3743 EVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRW 3802
V+ Y+ RGL+E K +F+ +T ++ + + E L++ KA P +
Sbjct: 3721 SVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLR----FPFKAGVVSPVDF 3776
Query: 3803 ILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKL 3862
+ W + LS++ +F + + I + K WK + +APE+EI P + + KL
Sbjct: 3777 LQHQGWGGIKALSEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNK-TALQKL 3835
Query: 3863 LLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTN 3922
++R PDR + + ++ + + K+ E + K++EES T + LS G DP
Sbjct: 3836 CMVRCLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLK 3895
Query: 3923 QIDALAKKLKL-----ECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFMEEL 3977
++AL KKL + +S+GQGQEV A + ++ ++G WV+LQN HL ++ L
Sbjct: 3896 DVEALGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQNIHLVARWLGTL 3955
Query: 3978 LETLIT-TEASDDSFRVWITTEPHDR-----FPITLLQTSLKFTNEPPQGVRAGLKRTFA 4031
+ L + S + +RV+I+ EP P +L+ ++K TNEPP G+ A L +
Sbjct: 3956 DKKLERYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALD 4015
Query: 4032 GINQDLLDISNLPM-WKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQ 4090
QD L++ M +K ML+ + + H+ V ERRKFG GWN Y FN+ D + S+ +
Sbjct: 4016 LFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLY 4075
Query: 4091 NHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYT 4150
N+L + V W+ +RY+ GE+ YGG +TDD+D+RL + + +M E
Sbjct: 4076 NYL---EANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAP 4132
Query: 4151 GYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKE-- 4208
G++IP Y EYI ++P ++GLHPNA+I + + T+ + T+ +QPKE
Sbjct: 4133 GFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETD 4192
Query: 4209 SGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRV 4268
SG G G +RE V + +D+L K+P + E+ + K + QE +RM +
Sbjct: 4193 SGAGTGVSREEKVKAVLDDILEKIPETFNMAEI---MAKAAEKTPYVVVAFQECERMNIL 4249
Query: 4269 ISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSST-LGFWFTELL 4327
+ +R SL +L L ++G + ++ ++ D ++ +P W ++ S L W+ +LL
Sbjct: 4250 TNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLL 4309
Query: 4328 ERNAQFSTWIFE-GRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQT 4386
R + W + P W+ GFFNPQ FLTA+ Q + R ++ W LD + + EV ++
Sbjct: 4310 LRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNE-WPLDKMCLSVEVTKKN 4368
Query: 4387 KEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPK 4446
+E++T+PP EG Y+YGL+M+GA WD + G + E+ K L +PV+ I AI +
Sbjct: 4369 REDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKN 4428
Query: 4447 LYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDI 4489
+Y CP+Y K R T++ L+T WIL VALL +
Sbjct: 4429 IYECPVY-KTRIRGPTYVWTFNLKTKEKAAKWILAAVALLLQV 4470
Score = 151 bits (381), Expect = 2e-35
Identities = 153/743 (20%), Positives = 308/743 (41%), Gaps = 61/743 (8%)
Query: 11 PDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASK--GLLNGIRDMLANIFLPAVLA 68
P LK ++F++ +++ IN + L+ + + L+ + ++L+++
Sbjct: 69 PQSLKSKGVYFIKTKSE-NINKDNYRARLLYGDISPTPVDQLIAVVEEVLSSL------- 120
Query: 69 TNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF------SK 122
LNQS+ + +E I + + L + G +K KT+ +
Sbjct: 121 ------LNQSENMAGWPQVVSEDIVKQVHRLKNEMFVMSGKIKGKTLLPIPEHLGSLDGT 174
Query: 123 LHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLI-ESEQMRKEAGDSGPLTELEHWKR 181
L + E + ++ N +H +E ++ W QI VL +S Q + P E E W
Sbjct: 175 LESMERIPSSLDNL-LLHAIETTIIDWSHQIRDVLSKDSAQALLDGLHPLPQVEFEFWDA 233
Query: 182 MSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTLE 241
I EQ+ P ++ +L A S +++ +T+ E+ D V YL L
Sbjct: 234 RLLNLKCIHEQLNRPKVNKIVEILEKAKSCYWPALQNVYTNVTEGLKEANDIVLYLKPLR 293
Query: 242 KVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAYI 301
+ + + D + I +++ I I S YYNT R+ + + NQ++ + ++
Sbjct: 294 ILLEEMEQADFTMLPTFIAKVLDTICFIWATSEYYNTPARIIVILQEFCNQIIEMTRTFL 353
Query: 302 TDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFH---KTRKLISESSGEKSFEVSEMYI 358
+ + E VL I + + KE ++ KL + +E
Sbjct: 354 SPEEVLKGLQGEIEEVLSGISLAVNVLKELYQTYDFCCVNMKLFFKDKEPVPWEFPSSLA 413
Query: 359 FGKFEAFCKRLEKITEMITVVQTYSTLSNSTIEGI--DIMAIKFRNIYQGVKKK------ 410
F + +F +R++ I E+ + L + G+ +++ IY V +
Sbjct: 414 FSRINSFFQRIQTIEELYKTAIEFLKLEKIELGGVRGNLLGSLVTRIYDEVFELVKVFAD 473
Query: 411 -QYDILDP------------RRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQA 457
+YD LDP + FD D+ DF KI L+ ++ F + +
Sbjct: 474 CKYDPLDPGDSVGPRAGLDELDSNFDRDYADFEIKIQDLDRRLATIFCQGFDDCSCIKSS 533
Query: 458 LQLLQRFQKL-NIPCLGLEINHTIERILQYYVAELDATKKLYHSQK------DDPPLARN 510
+LL L P + E+ +L+ + AELD K LY +Q + P + +N
Sbjct: 534 AKLLYMCGGLMERPLILAEVAPRYSVMLELFDAELDNAKILYDAQMAASEEGNIPLIHKN 593
Query: 511 MPPIAGKILWVRQLYRRISEPINYF-FKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYH 569
MPP+AG++ W +L R+ + + ++S + K ++Y+++ +L +
Sbjct: 594 MPPVAGQLKWSLELQERLEVSMKHLKHVEHPVMSGAEAKLTYQKYDEMMELLRCHREKIY 653
Query: 570 TAWIREISQ-LHYALQATLFVRHPETGKLLVNFDPKILEVVRETKCM-IKMKLDVPEQAK 627
W+ + Q H+ L L +R + + VNF ++ V+RE K + + + ++P+ A+
Sbjct: 654 QQWVAGVDQDCHFNLGQPLILRDAASNLIHVNFSKALVAVLREVKYLNFQQQKEIPDSAE 713
Query: 628 RLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSS 687
L + L+ ++ +Y+E+ + V + L+ +++ ++ L T L W+
Sbjct: 714 SLFSENETFRKFVGNLELIVGWYNEVMKAVEFL---LIKSELEAIDVKLLSAETTLFWNG 770
Query: 688 LTLESFFQEVELVLDMFNQLLKK 710
+ + QEV +L ++K
Sbjct: 771 EGVFQYIQEVREILHNLQNRMQK 793
>gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]
Length = 4024
Score = 1900 bits (4923), Expect = 0.0
Identities = 1184/3611 (32%), Positives = 1910/3611 (52%), Gaps = 154/3611 (4%)
Query: 976 VAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEI 1035
V HK+ K V++ S A E L+ + KY L T + V FLA N S +I
Sbjct: 469 VDAHKEKIKEVIMKESV------APTEHLRLYDKYDFLITRKAERDVDNFLAENHSYEKI 522
Query: 1036 RSEILHYATFEQEIDELK-PIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKK 1094
EI Y +EI I +G E+H E + AL K ++ + L + ++
Sbjct: 523 IDEICKYQKLIEEIQYTSIKTIRLGMFEMHCEELIRAL---VKRADIICGKLLAKMFRDH 579
Query: 1095 MSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNE----IQMDMTLGPIEEAYAIL 1150
+E+ + + + + ME + I+ E I+++ L + A L
Sbjct: 580 QEVNTRLCDEFERIAEKALSTPPNTAELMEMKAYIQKVEVTDMIELEQRLVDSKNCLAFL 639
Query: 1151 NRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVIN 1210
+ V + + +++ + ++ ++ + + +++ L E F E++ +
Sbjct: 640 IEY-VNFSPADMRLNNSVFQWYGRMGEIFEEHRKIIKEKIEQYQEGLKLRCERFVEELES 698
Query: 1211 FAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHK 1270
+A+ E Q + QI D K +++ E+ FG + Y K
Sbjct: 699 YAKQSEEFYSFGDLQDVQRYLKKAQILNGKLDLAADKIEQFNAEEEAFGWLPSVYPQRKK 758
Query: 1271 TRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQ 1330
+ LN +LY S+ + E + V+ +++ A++ + KL K D
Sbjct: 759 IQDGLNPYLRLYETAVEFSSNYRAWTEGPYHKVNPDQVEADIGNYWRGLYKLEKTFHDSP 818
Query: 1331 AFLDLKKRI----DDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIM 1386
L + K++ +DF + PL++++ N ++ RHW+ +S + G P DS + + +
Sbjct: 819 YALAMTKKVRSKVEDFKQHIPLIQVICNPGLRPRHWEAMSAIVGYPLQPSDDS-TVSSFL 877
Query: 1387 EAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGE 1446
+ L + D E I +A KE +E + ++I W +++ G +L + E
Sbjct: 878 DMNLEPYIDRFEGISEAASKEYSLEKAMEKMITEWDAVEFVIHSYRETGTFILASVD--E 935
Query: 1447 IITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFV 1506
I L++D ++ ++ + + P++K ++ W KL +I++EWL VQ W+YLE +F
Sbjct: 936 IQMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLLLQEILDEWLKVQATWLYLEPIFS 995
Query: 1507 GGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQ 1566
DI Q+P+E +RF +DK+W IM+ ++ +V+ D + + L +E LE+
Sbjct: 996 SPDIMSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTIDRML-ERLKKSNELLELIL 1054
Query: 1567 KSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYD 1626
K L YLEKKRL FPRFFF+S+ LLEIL + D +QPHL + I +V F + D
Sbjct: 1055 KGLNEYLEKKRLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCFEGIAKVEF-TETLD 1113
Query: 1627 RIMAVISREGEKIVLD---NSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQ 1683
I + S EGE + L ++ A+G VE WL++L ++ ++S+H + A + + ++
Sbjct: 1114 -ITHMKSSEGEVVELIEIISTAKARGQVEKWLVELERVMINSIHKVTGDATFAYTK--YE 1170
Query: 1684 LLPFLSHFPAQVGLLGIQMLWTHDSEEAL-RNAKDDRKIMQVTNQKFLDILNTLISQTTH 1742
+ ++ +P Q L Q+ WT + + A+ K + ++ N++ DI+ + +
Sbjct: 1171 RINWVRDWPGQTVLCVSQIFWTKEVQTAIPMGIKALEQYLKTCNRQIDDIVTLVRGK--- 1227
Query: 1743 DLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSIT 1802
LS +RV L+ + VH RD+ LVK +I +DFEWL Q R+Y++E+ +T +
Sbjct: 1228 -LSMQNRVTLGALVVLDVHARDVLSSLVKKNISDDSDFEWLSQLRYYWQENHLET--KMI 1284
Query: 1803 DVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRC 1862
+ Y E+LG + RLVITPLTDRCY TL AL +++GGAP GPAGTGKTETTKD+ +
Sbjct: 1285 NAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALHLHLGGAPEGPAGTGKTETTKDLAKA 1344
Query: 1863 LGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTAR 1922
+ K VVFNCSD +D+ LG+ FKGL G+W CFDEFNRI+L VLSV AQQI +
Sbjct: 1345 VAKQCVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNRIDLEVLSVVAQQILTIQRGI 1404
Query: 1923 KERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMR 1982
+F +G + L+P +F+TMNPGYAGR ELP+NLK FRTVAMMVPD +I
Sbjct: 1405 NAGADILMF-EGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFRTVAMMVPDYAMIAE 1463
Query: 1983 VKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDS 2042
+ L SCGF+ L+ K Y+LC EQL+ Q HYD+G+R + SVL G+ K P ++
Sbjct: 1464 IVLYSCGFVTARPLSVKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPNEN 1523
Query: 2043 ELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLI 2102
E +++R + D+NL K + D PLF + +DLFPG++L Y +L A+ L
Sbjct: 1524 EEILLLRSIIDVNLPKFLSHDLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCASMNLQ 1583
Query: 2103 NHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTE-CGRPHREMR----- 2156
++ K++Q+YE +VRHG M +G GKT+ +L A + C + E
Sbjct: 1584 MTAFFSEKILQVYEMMIVRHGFMIVGEPFGGKTSAYRVLAGALNDICEKGLMEENKVQIT 1643
Query: 2157 -MNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENL 2215
+NPK++T Q++G+ D+ +++W+DG+ + +R + + +LI DGPVDA+WIEN+
Sbjct: 1644 VLNPKSVTMGQLYGQFDSVSHEWSDGVLAVSFRAFASSVTPDRKWLIFDGPVDAVWIENM 1703
Query: 2216 NSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPIL 2275
N+VLDDNK L L +G+ I M+P L+FE ++E ASPATVSR GM+Y+ L WRP++
Sbjct: 1704 NTVLDDNKKLCLMSGEIIQMSPQMNLIFEPMDLEVASPATVSRCGMIYMEPHMLGWRPLM 1763
Query: 2276 QAWLKKRTAQEAAV----FLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGL 2331
+W+ A + + + L++++ + +++ + + N + +NL++
Sbjct: 1764 LSWVNLLPASVSVIQKEFIMGLFDRMVPVSVEFIRKHTKELSPTSDTNLVRSLMNLIDCF 1823
Query: 2332 IPS-------KEEGGVSCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQ------HE 2378
+ KE L +F+F L+WS+GA + R K LR+ +
Sbjct: 1824 MDDFADEVKLKERNDRETYSLLEGIFLFSLIWSVGASCTDDDRLKFNKILRELMESPISD 1883
Query: 2379 SKLDLPEIPKGSNQTM----------------YEFYVTDYGDWEHWNKKLQPYYYPTDSI 2422
+ ++ G+ QT Y+F G WE W KKL+ P
Sbjct: 1884 RTRNTFKLQSGTEQTSSKALTVPFPEKGTIYDYQFVTEGIGKWEPWIKKLKEAP-PIPKD 1942
Query: 2423 PEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYL-KKYDPEVQLSK 2481
++ I+VP +D IR + L++ + K + G GT K+V + +L + + E+
Sbjct: 1943 VMFNEIIVPTLDTIRYSALMELLTTHQKPSIFVGPTGTGKSVYITNFLLNQLNKEIYKPL 2002
Query: 2482 SLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEI 2541
+NFS+ T Q + S +DKR +GPP G++M VF+DD+NMP +G Q E+
Sbjct: 2003 LINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRMVVFVDDVNMPAREVYGAQPPIEL 2062
Query: 2542 VRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNA 2601
+RQ ++ Y L K +VD+Q++ AM PGGGRN + R R F + S+
Sbjct: 2063 LRQWLDHWNWYDL-KDCSMIKLVDIQIMCAMGPPGGGRNPVTPRYMRHFNIITINEFSDK 2121
Query: 2602 SIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLR 2661
S+ IF I + + C F + ++ +V+ L++ +LPTP+K HY+FNLR
Sbjct: 2122 SMYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLYKEAMKNLLPTPAKSHYLFNLR 2181
Query: 2662 DLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENI 2721
D SR+ QG+ + E + + L+ HE RV DR + D W ++ + +
Sbjct: 2182 DFSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRLLDNTDRSWLINYIQEILRNYM 2241
Query: 2722 GSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI----YELMPSFDFLAEKLQFY 2777
D + D + E + D F PK Y + D L ++ +
Sbjct: 2242 YEDFHELFQRLDFDNDGMVEADDLRSLMFCD--FHDPKREDTNYREIADVDNLRMIVEIH 2299
Query: 2778 QRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIA 2837
++N I + ++LV F+ A+ H+ +ISRI++ +ALLVGVGGSG+QS++RLA+ +A
Sbjct: 2300 LEEYNNISK-KPMNLVLFRFAIEHISRISRILKQPRSHALLVGVGGSGRQSVTRLAAHMA 2358
Query: 2838 GYQIFQITLTRSYNVTNLTDDLKA-LYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLS 2896
Y +FQ+ +++ Y+ T +DLK L K A + +G+ F+FTD++IK+E+FLE ++NLL+
Sbjct: 2359 DYSVFQVEISKGYDTTEWHEDLKVILRKCAEGEMQGV-FLFTDTQIKEESFLEDVSNLLN 2417
Query: 2897 SGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDN---LYEYFISRSRKNLHVVLCFS 2953
+GEI NLFA DE EI + + R+ + T + L+ FI R LHVVL S
Sbjct: 2418 AGEIPNLFALDEKQEICDKMRQ-LDRQRDKTKQTDGSPIALFNMFIDHCRSQLHVVLAMS 2476
Query: 2954 PVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETM 3013
P+G+ FR R KFP L++ CT+DWF WP +AL AVAS FL + I S EI+ ++
Sbjct: 2477 PIGDAFRNRLRKFPALVNCCTIDWFQSWPEDALQAVASRFLEE--IEMSEEIRDGCIDMC 2534
Query: 3014 GLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDK 3073
FH + +S+F +R +VTP SYL I+ +K + +K + + +R +GL+K
Sbjct: 2535 KSFHTSTIDLSKSFFVELQRYNYVTPTSYLELISTFKLLLEKKRSEVMKMKKRYEVGLEK 2594
Query: 3074 LMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKI 3133
L AS VA + +L +L VAS + DE++ + + AK + V+ + A +
Sbjct: 2595 LDSASSQVATMQMELEALHPQLKVASKEVDEMMIMIEKESVEVAKTEKIVKADETIANEQ 2654
Query: 3134 VDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLL 3193
+ K + ++ L A P LE A AAL+T+ DI V+ + PP + +M+ + +L
Sbjct: 2655 AMASKAIKDECDADLAGALPILESALAALDTLTAQDITVVKSMKSPPAGVKLVMEAICIL 2714
Query: 3194 FQKKIDPVTMDPEKSCCKPS--WGESLKLMSATGFLWSLQQFPKDTINEETVELLQP-YF 3250
K D + DP S K WG + +L+ FL SL ++ KD I + +++ Y
Sbjct: 2715 KGIKADKIP-DPTGSGKKIEDFWGPAKRLLGDMRFLQSLHEYDKDNIPPAYMNIIRKNYI 2773
Query: 3251 NMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGK 3310
D+ E + GL W +AM + + + V P K LA EG L +A L K
Sbjct: 2774 PNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVAPKKIKLAAAEGELKIAMDGLRK 2833
Query: 3311 AQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQ 3370
QA L E Q +L ++Q + +K DL N D C KK++ A LI GL GEK RW+
Sbjct: 2834 KQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERAEQLIGGLGGEKTRWSHT 2893
Query: 3371 SKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKIPFTENLNLIS 3430
+ E L GDIL+ +G ++YLG F +R K+ W + R IP +++ +L+
Sbjct: 2894 ALELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQTKE-WTTLCKGRDIPCSDDCSLMG 2952
Query: 3431 MLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQV 3490
L + TI W + GLP D SI NGII+ A R+PL+IDPQ+Q WIK+ EK N L V
Sbjct: 2953 TLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKWIKNMEKANSLYV 3012
Query: 3491 TSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECD 3550
L+ + LE+ + G P+L+E++ EELDP L+ +L K K G + +++GD +
Sbjct: 3013 IKLSEPDYVRTLENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGGSTCIRLGDSTIE 3072
Query: 3551 IMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVK 3610
F+ YITTKL NP + PE + K ++++F +T +G+++QLL V+ E+ +LE E+
Sbjct: 3073 YAPDFRFYITTKLRNPHYLPETSVKVTLLNFMITPEGMQDQLLGIVVAQERPDLEEEKQA 3132
Query: 3611 LLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAET 3670
L+ NKR++KE+ED +L LS+++G++++DE+ I +L ++K A E+S+K VA ET
Sbjct: 3133 LILQGAENKRQLKEIEDKILEVLSSSEGNILEDETAIKILSSSKALANEISQKQEVAEET 3192
Query: 3671 EIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQ 3730
E KI+ + +RP A SIL+F + +++ + MYQ SL F+ LF S+ SEKS +
Sbjct: 3193 EKKIDTTRMGYRPIAIHSSILFFSLADLANIEPMYQYSLTWFINLFILSIENSEKSEILA 3252
Query: 3731 KRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAAL 3790
KR+ + ++ TY ++ R L+E K LF +T+ + L + E++ L+ GG L
Sbjct: 3253 KRLQILKDHFTYSLYVNVCRSLFEKDKLLFSFCLTINLLLHERAINKAEWRFLLTGGIGL 3312
Query: 3791 DLKACPPKPY----RWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEE 3846
D PY W+ +W + L LP F I + R + GWK +D P E
Sbjct: 3313 D------NPYANLCTWLPQKSWDEICRLDDLPAFKTIRREFMRLKDGWKKVYDSLEPHHE 3366
Query: 3847 IIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDT 3906
+ P+ + D + ++L+IR PD+ + +++I + L + EP +L K + +S+
Sbjct: 3367 VFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQEFIINRLGRAFIEPPPFDLAKAFGDSNC 3426
Query: 3907 RTPLICFLSMGSDPTNQIDALAKKLKL---ECRTISMGQGQEVHARKLIQMSMQQGGWVL 3963
PLI LS G+DP + A + ++S+GQGQ A K+++ ++++G WV+
Sbjct: 3427 CAPLIFVLSPGADPMAALLKFADDQGYGGSKLSSLSLGQGQGPIAMKMLEKAVKEGTWVV 3486
Query: 3964 LQNCHLGLEFMEELLETL--ITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQG 4021
LQNCHL +M L + ++ E++ FR+W+T+ P FP+++LQ +K TNE P+G
Sbjct: 3487 LQNCHLATSWMPTLEKVCEELSPESTHPDFRMWLTSYPSPNFPVSVLQNGVKMTNEAPKG 3546
Query: 4022 VRAGLKRTFAGINQDLLDISNLP----------MWKPMLYTVAFLHSTVQERRKFGPLGW 4071
+RA + R++ L+D + P +K +LY + F H+ VQERRKFGPLGW
Sbjct: 3547 LRANIIRSY------LMDPISDPEFFGSCKKPEEFKKLLYGLCFFHALVQERRKFGPLGW 3600
Query: 4072 NIPYEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNC 4131
NIPYEFN D SVQ + L++ + + + +RYM GE YGGRVTDD+D+R L
Sbjct: 3601 NIPYEFNETDLRISVQQLHMFLNQYE---ELPYEALRYMTGECNYGGRVTDDWDRRTLRS 3657
Query: 4132 FARVWFSEKMFEPSFCFYTG---YKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADIT 4188
+F+ ++ E S + Y +P Y EY ++LP PE+FG++ NADIT
Sbjct: 3658 ILNKFFNPELVENSDYKFDSSGIYFVPPSGDHKSYIEYTKTLPLTPAPEIFGMNANADIT 3717
Query: 4189 YQSNTASAVLETITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKM 4248
+ + + I Q + +G G ++ + +V ++ D+L KLP ++ E R
Sbjct: 3718 KDQSETQLLFDNILLTQSRSAGAG-AKSSDEVVNEVASDILGKLPNNF-DIEAAMRRYPT 3775
Query: 4249 GHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQL 4308
+ SMN L QE+ R +++ +R S +++ AI+G +MS +L + + ++ + +IP++
Sbjct: 3776 TYTQSMNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEM 3835
Query: 4309 WKRVSWDS-STLGFWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRA 4367
W S+ S LG + + L R W G P VFW++GFF Q FLT +Q R
Sbjct: 3836 WMGKSYPSLKPLGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAFLTGAQQNYARK 3895
Query: 4368 HKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFT 4427
+ +D + EV+ +E PP +GV+I+GL++DGA+W+R+ KL ES PK+L+
Sbjct: 3896 YT-IPIDLLGFDYEVMED--KEYKHPPEDGVFIHGLFLDGASWNRKIKKLAESHPKILYD 3952
Query: 4428 QLPVLHIFAI-NSTAPKDPKLYVCPIYKKPRRTDL--------TFITVVYLRTVLSPDHW 4478
+PV+ + + PK P YV P+YK R + F+ + L + +HW
Sbjct: 3953 TVPVMWLKPCKRADIPKRPS-YVAPLYKTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHW 4011
Query: 4479 ILRGVALLCDI 4489
I RGVALLC +
Sbjct: 4012 IGRGVALLCQL 4022
>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 1896 bits (4911), Expect = 0.0
Identities = 1181/3618 (32%), Positives = 1906/3618 (52%), Gaps = 172/3618 (4%)
Query: 966 ARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEF 1025
A+ N+ + ++ D+ ++ +SS V + K A E F++Y LWT++ +K F
Sbjct: 946 AKDRMNYKMDLEDNTDLIEMREEVSSLVINAMKEAEEYQDSFERYSYLWTDNLQEFMKNF 1005
Query: 1026 LANN--------------------PSLTEIRSEILHYATFEQEIDELKPIIVV-GALELH 1064
L P+L + + +I Y +E+ + + V G L+
Sbjct: 1006 LIYGCAVTAEDLDTWTDDTIPKTPPTLAQFQEQIDSYEKLYEEVSKCENTKVFHGWLQCD 1065
Query: 1065 TEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIR--DLDDVRFA 1122
P K AL + W + R+L+ ++ + AF+ L++P++ D D +
Sbjct: 1066 CRPFKQALLSTIRRWGFMFKRHLSNHVTNSLADLEAFMKVARMGLTKPLKEGDYDGLVEV 1125
Query: 1123 MEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSV 1182
M L +++ + D P+++ +L + E+ +E + L + + A+ V
Sbjct: 1126 MGHLMKVKERQAATDNMFEPLKQTIELLKTYGEEMPEEIHLKLQELPEHWANTKKLAIQV 1185
Query: 1183 QEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIP-PQEASNRLQIFQASF 1241
+ + +Q S L + F F E + E P + P P ++ N++ + +
Sbjct: 1186 KLTVAPLQANEVSILRRKCQQFELKQHEFRERFRREAPFSFSDPNPYKSLNKVFLLKGIM 1245
Query: 1242 DDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWG 1301
+ L S LF +PV DY+ L +E+ LL++L+ + V +SI + W
Sbjct: 1246 EAL-------SKSGGLFEVPVPDYKQLKACHREVRLLKELWDMVVVVNTSIEDWKTTKWK 1298
Query: 1302 DVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRH 1361
D+++E+++ + +F R L K +K W AF+ L + + S + + N A+++RH
Sbjct: 1299 DINVEQMDIDCKKFAKDMRSLDKEMKTWDAFVGLDNTVKNVITSLRAVSELQNPAIRERH 1358
Query: 1362 WDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENW 1421
W ++ + T F + S+ L ++++ L ++D++ +I A+KE +E L + W
Sbjct: 1359 WQQLMQATQVKFKM-SEETTLADLLQLNLHSYEDEVRNIVDKAVKESGMEKVLKALDSTW 1417
Query: 1422 TNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKL 1481
+ G ++LK +E ++ +ED+ + L +L+ ++Y A F K + +W KL
Sbjct: 1418 SMMEFQHEPHPRTGTMMLKSSEV--LVETLEDNQVQLQNLMMSKYLAHFLKEVTSWQQKL 1475
Query: 1482 STSSDIIEEWLVVQNLWVYLEAVFVGG-DIAKQLPQEAKRFQNIDKSWIKIMQRAHENPN 1540
ST+ +I W VQ W +LE++F+G DI QLP +++RF +I++ + +M+ A + PN
Sbjct: 1476 STADSVISIWFEVQRTWSHLESIFIGSEDIRTQLPGDSQRFDDINQEFKALMEDAVKTPN 1535
Query: 1541 VINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASD 1600
V+ + L L + L +C+K+L YLE KRL FPRF+FVS LL+IL +D
Sbjct: 1536 VVEA-TSKPGLYNKLEALKKSLAICEKALAEYLETKRLAFPRFYFVSSADLLDILSNGND 1594
Query: 1601 SHTIQPHLPAVSDNINEVTFHAKDYDRIMAV----ISREGEKIVLDNSVMAKGPVEIWLL 1656
+ HL + D++ ++ F D+ + V S+E E +V D G VE+WL
Sbjct: 1595 PVEVSRHLSKLFDSLCKLKFRLDASDKPLKVGLGMYSKEDEYMVFDQECDLSGQVEVWLN 1654
Query: 1657 DLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAK 1716
+L S+L + I A + + ++ +PAQ+ L EE NA
Sbjct: 1655 RVLDRMCSTLRHEIPEAVVTYEEKPRE--QWILDYPAQIWWTTEVGLAFARLEEGYENAI 1712
Query: 1717 DDRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKS 1776
D N+K + LN LI+ +L+ DR+K T+ TI VH RD+ + KM ++S
Sbjct: 1713 KDY------NKKQISQLNVLITLLIGNLNAGDRMKIMTICTIDVHARDV---VAKMIVES 1763
Query: 1777 PTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQAL 1836
F W Q R + E+ +I D Y E+LG T RLVITPLTDRCYITL Q+L
Sbjct: 1764 SQAFTWQAQLRHRWDEEKRHCFANICDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQSL 1823
Query: 1837 GMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGC 1896
+ MGGAPAGPAGTGKTETTKD+GR LG V VFNCS+QMD++ G I+KGLAQ+G+WGC
Sbjct: 1824 HLIMGGAPAGPAGTGKTETTKDLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGC 1883
Query: 1897 FDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGR 1956
FDEFNRI + VLSV A Q+ V A + +KK F F G+ + L P GIF+TMNPGYAGR
Sbjct: 1884 FDEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFL-GEIIGLIPTVGIFITMNPGYAGR 1942
Query: 1957 QELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVH 2016
ELPENLK FR AM+VPD ++I + L + GFLE +LA+KF LY LC+E L+KQ H
Sbjct: 1943 AELPENLKALFRPCAMVVPDFELICEIMLMAEGFLEARLLARKFITLYTLCKELLSKQDH 2002
Query: 2017 YDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFP 2076
YD+GLR I SVL GS KR P +E ++MR LRD N+ K+V +D P+F+ LI DLFP
Sbjct: 2003 YDWGLRAIKSVLVVAGSLKRGDPSRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFP 2062
Query: 2077 GLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTT 2136
L + + + + L + LK+VQL E VRH + +G +GSGK+
Sbjct: 2063 ALDVPRKRDLNFEKIIKQSIVELKLQAEDSFVLKVVQLEELLQVRHSVFIVGNAGSGKSQ 2122
Query: 2137 VITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKG 2196
V+ L K R + ++PKA+T ++FG ++ T +W DG+FST+ R
Sbjct: 2123 VLKSLNKTYQNLKRKPVAVDLDPKAVTCDELFGIINPVTREWKDGLFSTIMRDLANITHD 2182
Query: 2197 ENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATV 2256
++ILDG +D +WIE+LN+V+DDNK LTLA+ +RIP+ + +L+FE+ ++ A+PATV
Sbjct: 2183 GPKWIILDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATV 2242
Query: 2257 SRMGMVYISSSALSWRPILQAWLKKRTAQ-EAAVFLTLYEKVFEDTYTYMKLNLNPKMQL 2315
SR G++YI+ + L W P++ +W+++R Q E A + L++K ++ +
Sbjct: 2243 SRAGILYINPADLGWNPVVSSWIERRKVQSEKANLMILFDKYLPTCLDKLRFGFKKITPV 2302
Query: 2316 LECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLG-ALLELESREKLEAFL 2374
E I L LLE L+ K S E FVF W+ G A+ + + + F
Sbjct: 2303 PEITVIQTILYLLECLLTEKTVPPDSPRELYELYFVFTCFWAFGGAMFQDQLVDYRVEFS 2362
Query: 2375 RQHESKLDLPEIPKGSNQTMYEFYVT-DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNV 2433
+ ++ + P S T++++Y+ D + W K+ + D +P +S LV
Sbjct: 2363 KWWINEFKTIKFP--SQGTIFDYYIDPDTKKFLPWTDKVPSFELDPD-VPLQAS-LVHTT 2418
Query: 2434 DNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMM 2493
+ IR + +D + ++ V+L G GT K+V++ L+ + + L +++ F+ T M
Sbjct: 2419 ETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKLESLNTDNYLVQAVPFNFYTTSAM 2478
Query: 2494 FQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYS 2553
Q +E ++K+ G YGPPG +K+ FIDD+NMP ++++G + ++RQ M+ Y
Sbjct: 2479 LQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAPHTLIRQHMDHRHWYD 2538
Query: 2554 LDKPGDFTTIVDV---QLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGII 2610
K T+ D+ Q +A M +P G I RL+R F VF + P ++ I+ I
Sbjct: 2539 RHK----LTLKDIHNCQYVACM-NPTSGSFTIDSRLQRHFCVFAVSFPGQEALTTIYNTI 2593
Query: 2611 GCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGM 2670
+ RS I + LV+ L Q LPT KFHY+FNLRDLS I+QG+
Sbjct: 2594 LTQHL-AFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLRDLSNIFQGL 2652
Query: 2671 LTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCIL 2730
L AE + L+ L+ HE RV D+ + +D++ + + ++ +
Sbjct: 2653 LFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLHRVTMASTKKFFDDLGDELLF 2712
Query: 2731 PEP-YFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTS 2789
+P F F + + +P VP + ++ P L + L Y NE+
Sbjct: 2713 AKPNIFCHFAQGIGDPK---------YVP-VTDMAPLNKLLVDVLDSY----NEV--NAV 2756
Query: 2790 LDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRS 2849
++LV F+DA+ H+ +I+RI+ + GNALLVGVGGSGKQSLSRLA++I+G +FQITL +
Sbjct: 2757 MNLVLFEDAVAHICRINRILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKG 2816
Query: 2850 YNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEM 2909
Y + +L DL A Y A F+ TDS++ +E FL +N+LL+SGEI LF DE+
Sbjct: 2817 YGIPDLKIDLAAQYIKAAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEV 2876
Query: 2910 DEITQGLISVMKRELPR--HPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFP 2967
+ I IS M+ ++ T + +++FI + R+ L V+LCFSPVG R R+ KFP
Sbjct: 2877 ENI----ISSMRPQVKSLGMNDTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFP 2932
Query: 2968 GLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESY 3027
+++ +DWF WP +AL++V++ FL + + E+K + M H V+E Y
Sbjct: 2933 AVVNCTAIDWFHEWPEDALVSVSARFLEETEGI-PWEVKASISFFMSYVHTTVNEMSRVY 2991
Query: 3028 FQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQD 3087
RR + TPK++L I Y+N+ A+K + + ER+ GL KL + V L
Sbjct: 2992 LATERRYNYTTPKTFLEQIKLYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAK 3051
Query: 3088 LAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESK 3147
LA++E EL + AD+++ V + A+ +K K + + K + I + ++ E+
Sbjct: 3052 LAIQEAELKQKNESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETD 3111
Query: 3148 LEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEK 3207
L A+PAL A+ AL+T+ N++ ++ PP ++ + V++L T K
Sbjct: 3112 LAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMIL--------TAPGGK 3163
Query: 3208 SCCKPSWGESLKLMSATG-FLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGN 3266
SW + +M FL SL++F K+ I E ++ +PY + E +
Sbjct: 3164 IPKDKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTA 3223
Query: 3267 VAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQ 3326
AGL SW + + FY + +V P + L + LA A +L + + + E A L +
Sbjct: 3224 AAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSNLT 3283
Query: 3327 AKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDIL 3386
+ F+ A EK+ +AD + + A+ L+ GL+ E IRW + + F++Q L GD+L
Sbjct: 3284 SAFEKATAEKIKCQQEADATNRVILLANRLVGGLASENIRWAESVENFRSQGVTLCGDVL 3343
Query: 3387 LCTGFLSYLGPFNQIFRNYLLKDQWEMELRARK--IPFTENLNLISMLVDPPTIGEWGLQ 3444
L + F+SY+G F + +RN L++ W + K IP T L+ +S+L D + W Q
Sbjct: 3344 LISAFVSYVGYFTKKYRNELMEKFWIPYIHNLKVPIPITNGLDPLSLLTDDADVATWNNQ 3403
Query: 3445 GLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLED 3504
GLP D +S +N I+ R+PL++D Q QG WIK+K + ++L+ L K + +E
Sbjct: 3404 GLPSDRMSTENATILGNTERWPLIVDAQLQGIKWIKNKYR-SELKAIRLGQKSYLDVIEQ 3462
Query: 3505 SLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLP 3564
++S G LLIE+I E +DP LD +L +N IK G +K+GDKE + F+L + TK
Sbjct: 3463 AISEGDTLLIENIGETVDPVLDPLLGRNTIKKGKY--IKIGDKEVEYHPKFRLILHTKYF 3520
Query: 3565 NPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKE 3624
NP + PE+ A+ ++I+F VT GLE+QLL V+ E+ +LE + L + K +KE
Sbjct: 3521 NPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVLKE 3580
Query: 3625 LEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPA 3684
LED+LL +LSA G+ + D +L+ L TTK TA+E+ EK+ A TE+KIN A+E +RPA
Sbjct: 3581 LEDSLLARLSAASGNFLGDTALVENLETTKHTASEIEEKVVEAKITEVKINEARENYRPA 3640
Query: 3685 ATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEV 3744
A R S+LYF++ +++ +N +YQ SL F +F++++ R+ + ++R+ N+ + +TY V
Sbjct: 3641 AERASLLYFILNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSV 3700
Query: 3745 FTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWIL 3804
+ Y+ RGL+E K +F+ +T ++ + + E L++ KA P ++
Sbjct: 3701 YMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLR----FPFKAGVVSPVDFLQ 3756
Query: 3805 DMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLL 3864
W + LS++ +F + + I + K WK + +APE+EI P + + KL +
Sbjct: 3757 HQGWGGIKALSEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKT-ALQKLCM 3815
Query: 3865 IRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQI 3924
+R PDR + + ++ + + K+ E + K++EES T + LS G DP +
Sbjct: 3816 VRCLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDV 3875
Query: 3925 DALAKKLKL-----ECRTISMGQGQEVHARKLIQMSMQQGGWVLLQ--------NCHLGL 3971
+AL KKL + +S+GQGQEV A + ++ ++G WV+LQ N HL
Sbjct: 3876 EALGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGGQHCRNIHLVA 3935
Query: 3972 EFMEELLETLIT-TEASDDSFRVWITTEPHDR-----FPITLLQTSLKFTNEPPQGVRAG 4025
++ L + L + S + +RV+I+ EP P +L+ ++K TNEPP G+ A
Sbjct: 3936 RWLGTLDKKLERYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHAN 3995
Query: 4026 LKRTFAGINQDLLDISNLPM-WKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSA 4084
L + QD L++ M +K ML+ + + H+ V ERRKFG GWN Y FN+ D +
Sbjct: 3996 LHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTI 4055
Query: 4085 SVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEP 4144
S+ + N+L+ V W+ +RY+ GE+ YGG +TDD+D+RL + + +M E
Sbjct: 4056 SINVLYNYLEA---NPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEG 4112
Query: 4145 SFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNI 4204
G++IP Y EYI ++P ++GLHPNA+I + + T+ + T+ +
Sbjct: 4113 DVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEM 4172
Query: 4205 QPKE--SGGGVGETREAIVYRLS-----------------------------EDMLSKLP 4233
QPKE SG G G +RE L +D+L K+P
Sbjct: 4173 QPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIP 4232
Query: 4234 PDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENL 4293
+ E+ + K + QE +RM + + +R SL +L L ++G + ++ ++
Sbjct: 4233 ETFNMAEI---MAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDV 4289
Query: 4294 RDALDNMYDARIPQLWKRVSWDSST-LGFWFTELLERNAQFSTWIFE-GRPNVFWMTGFF 4351
D ++ +P W ++ S L W+ +LL R + W + P W+ GFF
Sbjct: 4290 EDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFF 4349
Query: 4352 NPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWD 4411
NPQ FLTA+ Q + R ++ W LD + + EV ++ +E++T+PP EG Y+YGL+M+GA WD
Sbjct: 4350 NPQSFLTAIMQSMARKNE-WPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWD 4408
Query: 4412 RRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTFITVVYLRT 4471
+ G + E+ K L +PV+ I AI + +Y CP+Y K R T++ L+T
Sbjct: 4409 TQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVY-KTRIRGPTYVWTFNLKT 4467
Query: 4472 VLSPDHWILRGVALLCDI 4489
WIL VALL +
Sbjct: 4468 KEKAAKWILAAVALLLQV 4485
Score = 163 bits (412), Expect = 4e-39
Identities = 154/731 (21%), Positives = 308/731 (42%), Gaps = 46/731 (6%)
Query: 11 PDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASK--GLLNGIRDMLANIFLPAVLA 68
P LK ++F++ +++ IN + L+ + + L+ + ++L+++
Sbjct: 69 PQSLKSKGVYFIKTKSE-NINKDNYRARLLYGDISPTPVDQLIAVVEEVLSSL------- 120
Query: 69 TNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF------SK 122
LNQS+ + +E I + + L + G +K KT+ +
Sbjct: 121 ------LNQSENMAGWPQVVSEDIVKQVHRLKNEMFVMSGKIKGKTLLPIPEHLGSLDGT 174
Query: 123 LHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLI-ESEQMRKEAGDSGPLTELEHWKR 181
L + E + ++ N +H +E ++ W QI VL +S Q + P E E W
Sbjct: 175 LESMERIPSSLDNL-LLHAIETTIIDWSHQIRDVLSKDSAQALLDGLHPLPQVEFEFWDA 233
Query: 182 MSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTLE 241
I EQ+ P ++ +L A S +++ +T+ E+ D V YL L
Sbjct: 234 RLLNLKCIHEQLNRPKVNKIVEILEKAKSCYWPALQNVYTNVTEGLKEANDIVLYLKPLR 293
Query: 242 KVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAYI 301
+ + + D + I +++ I I S YYNT R+ + + NQ++ + ++
Sbjct: 294 ILLEEMEQADFTMLPTFIAKVLDTICFIWATSEYYNTPARIIVILQEFCNQIIEMTRTFL 353
Query: 302 TDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFH---KTRKLISESSGEKSFEVSEMYI 358
+ + E VL I + + KE ++ KL + +E
Sbjct: 354 SPEEVLKGLQGEIEEVLSGISLAVNVLKELYQTYDFCCVNMKLFFKDKEPVPWEFPSSLA 413
Query: 359 FGKFEAFCKRLEKITEMITVVQTYSTLSNSTIEGI--DIMAIKFRNIYQGVKKK------ 410
F + +F +R++ I E+ + L + G+ +++ IY V +
Sbjct: 414 FSRINSFFQRIQTIEELYKTAIEFLKLEKIELGGVRGNLLGSLVTRIYDEVFELVKVFAD 473
Query: 411 -QYDILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKL-N 468
+YD LDP + FD D+ DF KI L+ ++ F + + +LL L
Sbjct: 474 CKYDPLDPGDSNFDRDYADFEIKIQDLDRRLATIFCQGFDDCSCIKSSAKLLYMCGGLME 533
Query: 469 IPCLGLEINHTIERILQYYVAELDATKKLYHSQK------DDPPLARNMPPIAGKILWVR 522
P + E+ +L+ + AELD K LY +Q + P + +NMPP+AG++ W
Sbjct: 534 RPLILAEVAPRYSVMLELFDAELDNAKILYDAQMAASEEGNIPLIHKNMPPVAGQLKWSL 593
Query: 523 QLYRRISEPINYF-FKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQ-LH 580
+L R+ + + ++S + K ++Y+++ +L + W+ + Q H
Sbjct: 594 ELQERLEVSMKHLKHVEHPVMSGAEAKLTYQKYDEMMELLRCHREKIYQQWVAGVDQDCH 653
Query: 581 YALQATLFVRHPETGKLLVNFDPKILEVVRETKCM-IKMKLDVPEQAKRLLKLESKLKAD 639
+ L L +R + + VNF ++ V+RE K + + + ++P+ A+ L +
Sbjct: 654 FNLGQPLILRDAASNLIHVNFSKALVAVLREVKYLNFQQQKEIPDSAESLFSENETFRKF 713
Query: 640 KLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVEL 699
L+ ++ +Y+E+ V +V L+ +++ ++ L T L W+ + + QEV
Sbjct: 714 VGNLELIVGWYNEIKTIVKAVEFLLIKSELEAIDVKLLSAETTLFWNGEGVFQYIQEVRE 773
Query: 700 VLDMFNQLLKK 710
+L ++K
Sbjct: 774 ILHNLQNRMQK 784
>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 1895 bits (4909), Expect = 0.0
Identities = 1181/3618 (32%), Positives = 1906/3618 (52%), Gaps = 172/3618 (4%)
Query: 966 ARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEF 1025
A+ N+ + ++ D+ ++ +SS V + K A E F++Y LWT++ +K F
Sbjct: 946 AKDRMNYKMDLEDNTDLIEMREEVSSLVINAMKEAEEYQDSFERYSYLWTDNLQEFMKNF 1005
Query: 1026 LANN--------------------PSLTEIRSEILHYATFEQEIDELKPIIVV-GALELH 1064
L P+L + + +I Y +E+ + + V G L+
Sbjct: 1006 LIYGCAVTAEDLDTWTDDTIPKTPPTLAQFQEQIDSYEKLYEEVSKCENTKVFHGWLQCD 1065
Query: 1065 TEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIR--DLDDVRFA 1122
P K AL + W + R+L+ ++ + AF+ L++P++ D D +
Sbjct: 1066 CRPFKQALLSTIRRWGFMFKRHLSNHVTNSLADLEAFMKVARMGLTKPLKEGDYDGLVEV 1125
Query: 1123 MEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSV 1182
M L +++ + D P+++ +L + E+ +E + L + + A+ V
Sbjct: 1126 MGHLMKVKERQAATDNMFEPLKQTIELLKTYGEEMPEEIHLKLQELPEHWANTKKLAIQV 1185
Query: 1183 QEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIP-PQEASNRLQIFQASF 1241
+ + +Q S L + F F E + E P + P P ++ N++ + +
Sbjct: 1186 KLTVAPLQANEVSILRRKCQQFELKQHEFRERFRREAPFSFSDPNPYKSLNKVFLLKGIM 1245
Query: 1242 DDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWG 1301
+ L S LF +PV DY+ L +E+ LL++L+ + V +SI + W
Sbjct: 1246 EAL-------SKSGGLFEVPVPDYKQLKACHREVRLLKELWDMVVVVNTSIEDWKTTKWK 1298
Query: 1302 DVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRH 1361
D+++E+++ + +F R L K +K W AF+ L + + S + + N A+++RH
Sbjct: 1299 DINVEQMDIDCKKFAKDMRSLDKEMKTWDAFVGLDNTVKNVITSLRAVSELQNPAIRERH 1358
Query: 1362 WDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENW 1421
W ++ + T F + S+ L ++++ L ++D++ +I A+KE +E L + W
Sbjct: 1359 WQQLMQATQVKFKM-SEETTLADLLQLNLHSYEDEVRNIVDKAVKESGMEKVLKALDSTW 1417
Query: 1422 TNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKL 1481
+ G ++LK +E ++ +ED+ + L +L+ ++Y A F K + +W KL
Sbjct: 1418 SMMEFQHEPHPRTGTMMLKSSEV--LVETLEDNQVQLQNLMMSKYLAHFLKEVTSWQQKL 1475
Query: 1482 STSSDIIEEWLVVQNLWVYLEAVFVGG-DIAKQLPQEAKRFQNIDKSWIKIMQRAHENPN 1540
ST+ +I W VQ W +LE++F+G DI QLP +++RF +I++ + +M+ A + PN
Sbjct: 1476 STADSVISIWFEVQRTWSHLESIFIGSEDIRTQLPGDSQRFDDINQEFKALMEDAVKTPN 1535
Query: 1541 VINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASD 1600
V+ + L L + L +C+K+L YLE KRL FPRF+FVS LL+IL +D
Sbjct: 1536 VVEA-TSKPGLYNKLEALKKSLAICEKALAEYLETKRLAFPRFYFVSSADLLDILSNGND 1594
Query: 1601 SHTIQPHLPAVSDNINEVTFHAKDYDRIMAV----ISREGEKIVLDNSVMAKGPVEIWLL 1656
+ HL + D++ ++ F D+ + V S+E E +V D G VE+WL
Sbjct: 1595 PVEVSRHLSKLFDSLCKLKFRLDASDKPLKVGLGMYSKEDEYMVFDQECDLSGQVEVWLN 1654
Query: 1657 DLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAK 1716
+L S+L + I A + + ++ +PAQ+ L EE NA
Sbjct: 1655 RVLDRMCSTLRHEIPEAVVTYEEKPRE--QWILDYPAQIWWTTEVGLAFARLEEGYENAI 1712
Query: 1717 DDRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKS 1776
D N+K + LN LI+ +L+ DR+K T+ TI VH RD+ + KM ++S
Sbjct: 1713 RDY------NKKQISQLNVLITLLMGNLNAGDRMKIMTICTIDVHARDV---VAKMIVES 1763
Query: 1777 PTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQAL 1836
F W Q R + E+ +I D Y E+LG T RLVITPLTDRCYITL Q+L
Sbjct: 1764 SQAFTWQAQLRHRWDEEKRHCFANICDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQSL 1823
Query: 1837 GMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGC 1896
+ MGGAPAGPAGTGKTETTKD+GR LG V VFNCS+QMD++ G I+KGLAQ+G+WGC
Sbjct: 1824 HLIMGGAPAGPAGTGKTETTKDLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGC 1883
Query: 1897 FDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGR 1956
FDEFNRI + VLSV A Q+ V A + +KK F F G+ + L P GIF+TMNPGYAGR
Sbjct: 1884 FDEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFL-GEIIGLIPTVGIFITMNPGYAGR 1942
Query: 1957 QELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVH 2016
ELPENLK FR AM+VPD ++I + L + GFLE +LA+KF LY LC+E L+KQ H
Sbjct: 1943 AELPENLKALFRPCAMVVPDFELICEIMLMAEGFLEARLLARKFITLYTLCKELLSKQDH 2002
Query: 2017 YDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFP 2076
YD+GLR I SVL GS KR P +E ++MR LRD N+ K+V +D P+F+ LI DLFP
Sbjct: 2003 YDWGLRAIKSVLVVAGSLKRGDPSRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFP 2062
Query: 2077 GLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTT 2136
L + + + + L + LK+VQL E VRH + +G +GSGK+
Sbjct: 2063 ALDVPRKRDLNFEKIIKQSIVELKLQAEDSFVLKVVQLEELLQVRHSVFIVGNAGSGKSQ 2122
Query: 2137 VITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKG 2196
V+ L K R + ++PKA+T ++FG ++ T +W DG+FST+ R
Sbjct: 2123 VLKSLNKTYQNLKRKPVAVDLDPKAVTCDELFGIINPVTREWKDGLFSTIMRDLANITHD 2182
Query: 2197 ENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATV 2256
++ILDG +D +WIE+LN+V+DDNK LTLA+ +RIP+ + +L+FE+ ++ A+PATV
Sbjct: 2183 GPKWIILDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATV 2242
Query: 2257 SRMGMVYISSSALSWRPILQAWLKKRTAQ-EAAVFLTLYEKVFEDTYTYMKLNLNPKMQL 2315
SR G++YI+ + L W P++ +W+++R Q E A + L++K ++ +
Sbjct: 2243 SRAGILYINPADLGWNPVVSSWIERRKVQSEKANLMILFDKYLPTCLDKLRFGFKKITPV 2302
Query: 2316 LECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLG-ALLELESREKLEAFL 2374
E I L LLE L+ K S E FVF W+ G A+ + + + F
Sbjct: 2303 PEITVIQTILYLLECLLTEKTVPPDSPRELYELYFVFTCFWAFGGAMFQDQLVDYRVEFS 2362
Query: 2375 RQHESKLDLPEIPKGSNQTMYEFYVT-DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNV 2433
+ ++ + P S T++++Y+ D + W K+ + D +P +S LV
Sbjct: 2363 KWWINEFKTIKFP--SQGTIFDYYIDPDTKKFLPWTDKVPSFELDPD-VPLQAS-LVHTT 2418
Query: 2434 DNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMM 2493
+ IR + +D + ++ V+L G GT K+V++ L+ + + L +++ F+ T M
Sbjct: 2419 ETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKLESLNTDNYLVQAVPFNFYTTSAM 2478
Query: 2494 FQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYS 2553
Q +E ++K+ G YGPPG +K+ FIDD+NMP ++++G + ++RQ M+ Y
Sbjct: 2479 LQGVLEKPLEKKSGRNYGPPGTKKLVYFIDDMNMPEVDKYGTVAPHTLIRQHMDHRHWYD 2538
Query: 2554 LDKPGDFTTIVDV---QLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGII 2610
K T+ D+ Q +A M +P G I RL+R F VF + P ++ I+ I
Sbjct: 2539 RHK----LTLKDIHNCQYVACM-NPTSGSFTIDSRLQRHFCVFAVSFPGQEALTTIYNTI 2593
Query: 2611 GCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGM 2670
+ RS I + LV+ L Q LPT KFHY+FNLRDLS I+QG+
Sbjct: 2594 LTQHL-AFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKFHYVFNLRDLSNIFQGL 2652
Query: 2671 LTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCIL 2730
L AE + L+ L+ HE RV D+ + +D++ + + ++ +
Sbjct: 2653 LFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEKDQETLHRVTMASTKKFFDDLGDELLF 2712
Query: 2731 PEP-YFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTS 2789
+P F F + + +P VP + ++ P L + L Y NE+
Sbjct: 2713 AKPNIFCHFAQGIGDPK---------YVP-VTDMAPLNKLLVDVLDSY----NEV--NAV 2756
Query: 2790 LDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRS 2849
++LV F+DA+ H+ +I+RI+ + GNALLVGVGGSGKQSLSRLA++I+G +FQITL +
Sbjct: 2757 MNLVLFEDAVAHICRINRILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKG 2816
Query: 2850 YNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEM 2909
Y + +L DL A Y A F+ TDS++ +E FL +N+LL+SGEI LF DE+
Sbjct: 2817 YGIPDLKIDLAAQYIKAAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEV 2876
Query: 2910 DEITQGLISVMKRELPR--HPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFP 2967
+ I IS M+ ++ T + +++FI + R+ L V+LCFSPVG R R+ KFP
Sbjct: 2877 ENI----ISSMRPQVKSLGMNDTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFP 2932
Query: 2968 GLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESY 3027
+++ +DWF WP +AL++V++ FL + + E+K + M H V+E Y
Sbjct: 2933 AVVNCTAIDWFHEWPEDALVSVSARFLEETEGI-PWEVKASISFFMSYVHTTVNEMSRVY 2991
Query: 3028 FQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQD 3087
RR + TPK++L I Y+N+ A+K + + ER+ GL KL + V L
Sbjct: 2992 LATERRYNYTTPKTFLEQIKLYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAK 3051
Query: 3088 LAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESK 3147
LA++E EL + AD+++ V + A+ +K K + + K + I + ++ E+
Sbjct: 3052 LAIQEAELKQKNESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETD 3111
Query: 3148 LEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEK 3207
L A+PAL A+ AL+T+ N++ ++ PP ++ + V++L T K
Sbjct: 3112 LAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMIL--------TAPGGK 3163
Query: 3208 SCCKPSWGESLKLMSATG-FLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGN 3266
SW + +M FL SL++F K+ I E ++ +PY + E +
Sbjct: 3164 IPKDKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTA 3223
Query: 3267 VAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQ 3326
AGL SW + + FY + +V P + L + LA A +L + + + E A L +
Sbjct: 3224 AAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSNLT 3283
Query: 3327 AKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDIL 3386
+ F+ A EK+ +AD + + A+ L+ GL+ E IRW + + F++Q L GD+L
Sbjct: 3284 SAFEKATAEKIKCQQEADATNRVILLANRLVGGLASENIRWAESVENFRSQGVTLCGDVL 3343
Query: 3387 LCTGFLSYLGPFNQIFRNYLLKDQWEMELRARK--IPFTENLNLISMLVDPPTIGEWGLQ 3444
L + F+SY+G F + +RN L++ W + K IP T L+ +S+L D + W Q
Sbjct: 3344 LISAFVSYVGYFTKKYRNELMEKFWIPYIHNLKVPIPITNGLDPLSLLTDDADVATWNNQ 3403
Query: 3445 GLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLED 3504
GLP D +S +N I+ R+PL++D Q QG WIK+K + ++L+ L K + +E
Sbjct: 3404 GLPSDRMSTENATILGNTERWPLIVDAQLQGIKWIKNKYR-SELKAIRLGQKSYLDVIEQ 3462
Query: 3505 SLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLP 3564
++S G LLIE+I E +DP LD +L +N IK G +K+GDKE + F+L + TK
Sbjct: 3463 AISEGDTLLIENIGETVDPVLDPLLGRNTIKKGKY--IKIGDKEVEYHPKFRLILHTKYF 3520
Query: 3565 NPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKE 3624
NP + PE+ A+ ++I+F VT GLE+QLL V+ E+ +LE + L + K +KE
Sbjct: 3521 NPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVLKE 3580
Query: 3625 LEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPA 3684
LED+LL +LSA G+ + D +L+ L TTK TA+E+ EK+ A TE+KIN A+E +RPA
Sbjct: 3581 LEDSLLARLSAASGNFLGDTALVENLETTKHTASEIEEKVVEAKITEVKINEARENYRPA 3640
Query: 3685 ATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEV 3744
A R S+LYF++ +++ +N +YQ SL F +F++++ R+ + ++R+ N+ + +TY V
Sbjct: 3641 AERASLLYFILNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSV 3700
Query: 3745 FTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWIL 3804
+ Y+ RGL+E K +F+ +T ++ + + E L++ KA P ++
Sbjct: 3701 YMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLR----FPFKAGVVSPVDFLQ 3756
Query: 3805 DMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLL 3864
W + LS++ +F + + I + K WK + +APE+EI P + + KL +
Sbjct: 3757 HQGWGGIKALSEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKT-ALQKLCM 3815
Query: 3865 IRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQI 3924
+R PDR + + ++ + + K+ E + K++EES T + LS G DP +
Sbjct: 3816 VRCLRPDRMTYAIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDV 3875
Query: 3925 DALAKKLKL-----ECRTISMGQGQEVHARKLIQMSMQQGGWVLLQ--------NCHLGL 3971
+AL KKL + +S+GQGQEV A + ++ ++G WV+LQ N HL
Sbjct: 3876 EALGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGGQHCRNIHLVA 3935
Query: 3972 EFMEELLETLIT-TEASDDSFRVWITTEPHDR-----FPITLLQTSLKFTNEPPQGVRAG 4025
++ L + L + S + +RV+I+ EP P +L+ ++K TNEPP G+ A
Sbjct: 3936 RWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHAN 3995
Query: 4026 LKRTFAGINQDLLDISNLPM-WKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSA 4084
L + QD L++ M +K ML+ + + H+ V ERRKFG GWN Y FN+ D +
Sbjct: 3996 LHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTI 4055
Query: 4085 SVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEP 4144
S+ + N+L+ V W+ +RY+ GE+ YGG +TDD+D+RL + + +M E
Sbjct: 4056 SINVLYNYLEA---NPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEG 4112
Query: 4145 SFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNI 4204
G++IP Y EYI ++P ++GLHPNA+I + + T+ + T+ +
Sbjct: 4113 DVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEM 4172
Query: 4205 QPKE--SGGGVGETREAIVYRLS-----------------------------EDMLSKLP 4233
QPKE SG G G +RE L +D+L K+P
Sbjct: 4173 QPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIP 4232
Query: 4234 PDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENL 4293
+ E+ + K + QE +RM + + +R SL +L L ++G + ++ ++
Sbjct: 4233 ETFNMAEI---MAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDV 4289
Query: 4294 RDALDNMYDARIPQLWKRVSWDSST-LGFWFTELLERNAQFSTWIFE-GRPNVFWMTGFF 4351
D ++ +P W ++ S L W+ +LL R + W + P W+ GFF
Sbjct: 4290 EDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFF 4349
Query: 4352 NPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWD 4411
NPQ FLTA+ Q + R ++ W LD + + EV ++ +E++T+PP EG Y+YGL+M+GA WD
Sbjct: 4350 NPQSFLTAIMQSMARKNE-WPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWD 4408
Query: 4412 RRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTFITVVYLRT 4471
+ G + E+ K L +PV+ I AI + +Y CP+Y K R T++ L+T
Sbjct: 4409 TQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVY-KTRIRGPTYVWTFNLKT 4467
Query: 4472 VLSPDHWILRGVALLCDI 4489
WIL VALL +
Sbjct: 4468 KEKAAKWILAAVALLLQV 4485
Score = 163 bits (412), Expect = 4e-39
Identities = 154/731 (21%), Positives = 308/731 (42%), Gaps = 46/731 (6%)
Query: 11 PDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASK--GLLNGIRDMLANIFLPAVLA 68
P LK ++F++ +++ IN + L+ + + L+ + ++L+++
Sbjct: 69 PQSLKSKGVYFIKTKSE-NINKDNYRARLLYGDISPTPVDQLIAVVEEVLSSL------- 120
Query: 69 TNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF------SK 122
LNQS+ + +E I + + L + G +K KT+ +
Sbjct: 121 ------LNQSENMAGWPQVVSEDIVKQVHRLKNEMFVMSGKIKGKTLLPIPEHLGSLDGT 174
Query: 123 LHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLI-ESEQMRKEAGDSGPLTELEHWKR 181
L + E + ++ N +H +E ++ W QI VL +S Q + P E E W
Sbjct: 175 LESMERIPSSLDNL-LLHAIETTIIDWSHQIRDVLSKDSAQALLDGLHPLPQVEFEFWDT 233
Query: 182 MSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTLE 241
I EQ+ P ++ +L A S +++ +T+ E+ D V YL L
Sbjct: 234 RLLNLKCIHEQLNRPKVNKIVEILEKAKSCYWPALQNVYTNVTEGLKEANDIVLYLKPLR 293
Query: 242 KVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAYI 301
+ + + D + I +++ I I S YYNT R+ + + NQ++ + ++
Sbjct: 294 ILLEEMEQADFTMLPTFIAKVLDTICFIWATSEYYNTPARIIVILQEFCNQIIEMTRTFL 353
Query: 302 TDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFH---KTRKLISESSGEKSFEVSEMYI 358
+ + E VL I + + KE ++ KL + +E
Sbjct: 354 SPEEVLKGLQGEIEEVLSGISLAVNVLKELYQTYDFCCVNMKLFFKDKEPVPWEFPSSLA 413
Query: 359 FGKFEAFCKRLEKITEMITVVQTYSTLSNSTIEGI--DIMAIKFRNIYQGVKKK------ 410
F + +F +R++ I E+ + L + G+ +++ IY V +
Sbjct: 414 FSRINSFFQRIQTIEELYKTAIEFLKLEKIELGGVRGNLLGSLVTRIYDEVFELVKVFAD 473
Query: 411 -QYDILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKL-N 468
+YD LDP + FD D+ DF KI L+ ++ F + + +LL L
Sbjct: 474 CKYDPLDPGDSNFDRDYADFEIKIQDLDRRLATIFCQGFDDCSCIKSSAKLLYMCGGLME 533
Query: 469 IPCLGLEINHTIERILQYYVAELDATKKLYHSQK------DDPPLARNMPPIAGKILWVR 522
P + E+ +L+ + AELD K LY +Q + P + +NMPP+AG++ W
Sbjct: 534 RPLILAEVAPRYSVMLELFDAELDNAKILYDAQMAASEEGNIPLIHKNMPPVAGQLKWSL 593
Query: 523 QLYRRISEPINYF-FKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQ-LH 580
+L R+ + + ++S + K ++Y+++ +L + W+ + Q H
Sbjct: 594 ELQERLEVSMKHLKHVEHPVMSGAEAKLTYQKYDEMMELLRCHREKIYQQWVAGVDQDCH 653
Query: 581 YALQATLFVRHPETGKLLVNFDPKILEVVRETKCM-IKMKLDVPEQAKRLLKLESKLKAD 639
+ L L +R + + VNF ++ V+RE K + + + ++P+ A+ L +
Sbjct: 654 FNLGQPLILRDAASNLIHVNFSKALVAVLREVKYLNFQQQKEIPDSAESLFSENETFRKF 713
Query: 640 KLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVEL 699
L+ ++ +Y+E+ V +V L+ +++ ++ L T L W+ + + QEV
Sbjct: 714 VGNLELIVGWYNEIKTIVKAVEFLLIKSELEAIDVKLLSAETTLFWNGEGVFQYIQEVRE 773
Query: 700 VLDMFNQLLKK 710
+L ++K
Sbjct: 774 ILHNLQNRMQK 784
>gi|51479173 dynein, axonemal, heavy chain 11 [Homo sapiens]
Length = 4523
Score = 1825 bits (4726), Expect = 0.0
Identities = 1150/3573 (32%), Positives = 1879/3573 (52%), Gaps = 138/3573 (3%)
Query: 988 LLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFL--------------ANN---- 1029
+++ VN + K + + + LW +DR +K FL AN
Sbjct: 1016 IMNRVVNVINKVL-DFRNTLETHTYLWVDDRAEFMKHFLLYGHAVSSDEMDAHANEEIPE 1074
Query: 1030 --PSLTEIRSEILHYATFEQEIDELKPIIVVGA-LELHTEPMKLALSIEAKAWKMLLCRY 1086
P+L + + +I Y ++ + + V + ++ +P K++L K W + +
Sbjct: 1075 QPPTLEQFKEQIDIYEALYVQMSKFEDFRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEH 1134
Query: 1087 LNEEYKKKMSYMIAFINEYLKKLSRPIR--DLDDVRFAMEALSCIRDNEIQMDMTLGPIE 1144
L ++ + FI E L R + D D + M L +R + D P++
Sbjct: 1135 LLRFVIDSLNELQEFIKETDSGLQRELNEGDHDGLVDIMVHLLAVRSRQRATDELFEPLK 1194
Query: 1145 EAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVF 1204
E +L + ++ ++ ++ L + + A +V+ ++ + + + + +F
Sbjct: 1195 ETITLLESYGQKMPEQVYIQLEELPERWETTKKIAATVRHEVSPLHNAEVTLIRKKCILF 1254
Query: 1205 REDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTD 1264
F E + P+ N + L + L + + +LF + + +
Sbjct: 1255 DAKQAEFRERFRHYAPLGFNA--ENPYTALDKANEELEALEEEMLQMQESTRLFEVALPE 1312
Query: 1265 YEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR---- 1320
Y+ + + RKE+ LL+ L+ + V SI + + W + +E+++ EL F
Sbjct: 1313 YKQMKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKASSITEI 1372
Query: 1321 -KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDS 1379
L K ++ W A+ L+ + D + S + + + A++ RHW ++ + G F + +++
Sbjct: 1373 WSLNKEVRVWDAYTGLEGTVKDMTASLRAITELQSPALRDRHWHQLMKAIGVKFLI-NEA 1431
Query: 1380 FCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLL 1439
L +++ L + +DD+ I A+KE E +T++ + W S+ G LL
Sbjct: 1432 TTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFSYEVHYRTGIPLL 1491
Query: 1440 KGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWV 1499
K E ++ +E + + L +LL ++Y F + + +W KL+ + +I W+ VQ W
Sbjct: 1492 KSDE--QLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWS 1549
Query: 1500 YLEAVFV-GGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHL 1558
+LE++FV DI QL ++A+RF +D + ++M + + NV+ + + L L
Sbjct: 1550 HLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPN-LYEKLKDL 1608
Query: 1559 HEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEV 1618
+L +C+K+L YLE KR+ FPRF+FVS LL+IL + + + HL + D+I ++
Sbjct: 1609 QSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQPKQVTCHLAKLFDSIADL 1668
Query: 1619 TFHAKD---YDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFY 1675
F R + + S+E E + G VE WLL L + ++ + I A
Sbjct: 1669 QFEDNQDVSAHRAVGMYSKEKEYVPFQAECECVGHVETWLLQLEQTMQETVRHSITEAIV 1728
Query: 1676 QISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKI-MQVTNQKFLDILN 1734
+ +L F FPAQV L Q+ WT D A ++ + ++ ++K + LN
Sbjct: 1729 AYEEKPRELWIF--DFPAQVALTSSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLN 1786
Query: 1735 TLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLV--KMHIKSPTDFEWLKQSRFYFKE 1792
TLI+ +L DR K T+ TI VH RD+ L+ K + SP F WL Q R +++
Sbjct: 1787 TLITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKQVVVSPQAFTWLSQLRHRWED 1846
Query: 1793 DLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGK 1852
V+I D F Y E+LG + RLVITPLTDRCYITL Q+L + M GAPAGPAGTGK
Sbjct: 1847 TQKHCFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGK 1906
Query: 1853 TETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAA 1912
TETTKD+GR LG V VFNCS+QMD++ +G I+KGL Q+G+WGCFDEFNRI + VLSV A
Sbjct: 1907 TETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVA 1966
Query: 1913 QQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAM 1972
Q+ ++ A + RKK+F+F G+ + L P GIF+TMNPGYAGR ELPENLK FR AM
Sbjct: 1967 VQVKMIHDAIRNRKKRFVFL-GEAITLKPSVGIFITMNPGYAGRTELPENLKALFRPCAM 2025
Query: 1973 MVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLG 2032
+ PD ++I + L + GF++ LA+KF LY LC+E L+KQ HYD+GLR I SVL G
Sbjct: 2026 VAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAG 2085
Query: 2033 SQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAV 2092
S KR E ++MR LRD N+ K+V +D P+FL L+ DLFP L + + V
Sbjct: 2086 SLKRGDKNRPEDQVLMRALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMV 2145
Query: 2093 AHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPH 2152
L + LK+VQL E VRH + +G +G+GK+ ++ L + +
Sbjct: 2146 RQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVGNAGTGKSKILRTLNRTYVNMKQKP 2205
Query: 2153 REMRMNPKAITAPQMFGRLDTATNDWTD---------GIFSTLWRKTLKAKKGENIFLIL 2203
+NPKA+T ++FG + AT +W D G+FS++ R+ K +++L
Sbjct: 2206 VWNDLNPKAVTTDELFGFIHHATREWKDGKIVYSYFIGLFSSILREQANLKHDGPKWIVL 2265
Query: 2204 DGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVY 2263
DG +D +WIE+LN+V+DDNK LTLA+ +RI + P +LLFE+H++ +A+PATVSR G++Y
Sbjct: 2266 DGDIDPMWIESLNTVMDDNKVLTLASNERIALTPFMRLLFEIHHLRSATPATVSRAGILY 2325
Query: 2264 ISSSALSWRPILQAWLKKRTAQEAAVFLT-LYEKVFEDTYTYMKLNLNPKMQLLECNYIV 2322
++ L W P + +W+ +R Q LT L++K ++ + + E + +
Sbjct: 2326 VNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYVPACLDKLRTSFKTITSIPESSLVQ 2385
Query: 2323 QSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLGALLELESREKLEA-FLRQHESKL 2381
LLE L+ + S E FVF +W+ G L + +A F R + ++
Sbjct: 2386 TLCVLLECLLTPENVPSDSPKEVYEVYFVFACIWAFGGTLLQDQISDYQADFSRWWQKEM 2445
Query: 2382 DLPEIPKGSNQTMYEFYVTDYGDWEHWNKKLQPY-----YYPTDSIPEYSSILVPNVDNI 2436
+ P S T++++YV +H KKL P+ + D ++LV +
Sbjct: 2446 KAVKFP--SQGTIFDYYV------DHKTKKLLPWADKIAQFTMDPDVPLQTVLVHTTETA 2497
Query: 2437 RTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQR 2496
R + ++ + ++ K ++L G G KTV V L + +S+ + F+ T Q+
Sbjct: 2498 RLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLSEDYIVSR-VPFNYYTTSTALQK 2556
Query: 2497 TIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDK 2556
+E ++K+ G YGP G +K+ FIDD+NMP ++ +G + ++RQ ++ Y K
Sbjct: 2557 ILEKPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQK 2616
Query: 2557 PGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFD 2616
I + Q +A M +P G I RL+R FTVF PS +++ I+G I +F
Sbjct: 2617 V-MLKEIHNCQYVACM-NPMVGSFTINPRLQRHFTVFAFNFPSLDALNTIYGQIFSFHFQ 2674
Query: 2617 PCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAE 2676
++F P I L+ Q LPT KFHYIFNLRDLS ++QG+L +
Sbjct: 2675 Q-QAFAPSILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGIL-FASP 2732
Query: 2677 ECASIP-TLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYF 2735
EC P L+ L+ HE +RV D+ I +D F + + + +L +P
Sbjct: 2733 ECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGIDSHMLLQQPLI 2792
Query: 2736 VDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFF 2795
D +D + K +E++ + L E L Y NE+ ++ LV F
Sbjct: 2793 YCHF-------ADRGKDPHYMPVKDWEVLKT--ILTETLDNY----NEL--NAAMHLVLF 2837
Query: 2796 KDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNL 2855
+DAM H+ +ISRI+RT G ALLVGVGGSGKQSLSRLA+++ G ++FQITLT Y + L
Sbjct: 2838 EDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQEL 2897
Query: 2856 TDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQG 2915
DL LY GA F+ TD+++ DE+FL +N+LL+SGEI +LF+ +++D+I G
Sbjct: 2898 RVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISG 2957
Query: 2916 LISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTM 2975
+ + + + +N +++F++R R L ++LCFSPVG R R+ KFP +++ +
Sbjct: 2958 IHNEV--HALGMVDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIVNCTAI 3015
Query: 2976 DWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRA 3035
DWF WP+EAL++V+ F+ + + K + M H V+E Y+Q RR
Sbjct: 3016 DWFHAWPQEALVSVSRRFIEETKGI-EPVHKDSISLFMAHVHTTVNEMSTRYYQNERRHN 3074
Query: 3036 HVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKEL 3095
+ TPKS+L I+ +KN+ +K ++E+ ER+ G+ KL + V L LA +E EL
Sbjct: 3075 YTTPKSFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAEL 3134
Query: 3096 AVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPAL 3155
+ + A+ ++ ++ + + ++ K + K I E+ ++ + E+ L A+PAL
Sbjct: 3135 QLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQRECEADLLKAEPAL 3194
Query: 3156 EEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWG 3215
A AALNT+ +++ ++ PP + + V++L + V D K G
Sbjct: 3195 VAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPR-GRVPKDRSWKAAKVFMG 3253
Query: 3216 ESLKLMSATGFLWSLQQFPKDTINEETVELLQPYFNMD-DYTFESAKKVCGNVAGLLSWT 3274
+ FL +L + K+ I E ++++ ++ D ++ + AGL +W
Sbjct: 3254 K------VDDFLQALINYDKEHIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWV 3307
Query: 3275 LAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMN 3334
+ + FY + +V P + LA+ LA A +L + L + L ++ A F+ A
Sbjct: 3308 INIIKFYEVYCDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATA 3367
Query: 3335 EKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSY 3394
EK+ + + K ++ A+ L+ L +KIRW Q K F+AQ L GD+LL F+SY
Sbjct: 3368 EKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAAFVSY 3427
Query: 3395 LGPFNQIFRNYLLKDQWEMELRAR-KIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSI 3453
+GPF + +R L+ +W L+ + IP TE L+LISML D TI W +GLP D +S
Sbjct: 3428 VGPFTRQYRQELVHCKWVPFLQQKVSIPLTEGLDLISMLTDDATIAAWNNEGLPSDRMST 3487
Query: 3454 QNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLL 3513
+N I+T R+PL+IDPQ QG WIK+K DL+VT L K F +E +L+ G +L
Sbjct: 3488 ENAAILTHCERWPLVIDPQQQGIKWIKNK-YGMDLKVTHLGQKGFLNAIETALAFGDVIL 3546
Query: 3514 IEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEIN 3573
IE++ E +DP LD +L +N IK G +++GDKEC+ F+L + TKL NP + PE+
Sbjct: 3547 IENLEETIDPVLDPLLGRNTIKKGK--YIRIGDKECEFNKNFRLILHTKLANPHYKPELQ 3604
Query: 3574 AKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKL 3633
A+T++++FTVT GLE QLL V+ E+ +LE ++ L + K ++K LED+LL +L
Sbjct: 3605 AQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRL 3664
Query: 3634 SATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYF 3693
SA +GS +DD L+ L TK T AE+ K+ A E E KIN A+E +RP A R S+LYF
Sbjct: 3665 SAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYF 3724
Query: 3694 LITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLY 3753
+I ++ +N +YQ SL F LF +++ +++K Q RI+ ++E +T+ VF Y+ + L+
Sbjct: 3725 VINDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILMESITHAVFLYTSQALF 3784
Query: 3754 ENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWILDMTWLNLVE 3813
E K F+ M +I L++ + E L++ ++ P ++ +W +
Sbjct: 3785 EKDKLTFLSQMAFQILLRKKEIDPLELDFLLR----FTVEHTHLSPVDFLTSQSWSAIKA 3840
Query: 3814 LSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRT 3873
++ + +F I + + K W+ W + + PE+E +P + KL+L+R+ PDR
Sbjct: 3841 IAVMEEFRGIDRDVEGSAKQWRKWVESECPEKEKLPQEWKKK-SLIQKLILLRAMRPDRM 3899
Query: 3874 VFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKL 3933
+ R ++ + L KY E L+L K +EES TP+ LS G D ++ L K+L
Sbjct: 3900 TYALRNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGF 3959
Query: 3934 -----ECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHL---GLEFMEELLETLITTE 3985
+ +S+GQGQE A ++ + + G WV+LQN HL L +E+LLE ++
Sbjct: 3960 TIDSGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERF--SQ 4017
Query: 3986 ASDDSFRVWITTE----PHDR-FPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDI 4040
S +RV+++ E P + P LL+ S+K TNEPP G+ A L +QD L+I
Sbjct: 4018 GSHRDYRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEI 4077
Query: 4041 -SNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIK 4099
S +K +L+++ + H+ V R +FGP GW+ Y FN D + + N+L +
Sbjct: 4078 CSKEQEFKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYL---EAN 4134
Query: 4100 KGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTGYKIPLCKT 4159
V W +RY+ GE+ YGG +TDD+D++L + + + + E G+ P
Sbjct: 4135 SKVPWEDLRYLFGEIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLD 4194
Query: 4160 LDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKE--SGGGVGETR 4217
Y +YI+ + ++P ++GLHPNA+I + + T++ + T+ +QP+ SG +G++
Sbjct: 4195 YAGYHQYIEEMLPPESPALYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQST 4254
Query: 4218 EAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLS 4277
E V + +D+L KLP ++ E+ + K + + + QE +RM +I +R SL
Sbjct: 4255 EEKVKNVLDDILEKLPEEFNMAEI---MQKNSNRSPYVLVCFQECERMNILIREIRISLE 4311
Query: 4278 DLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSS-TLGFWFTELLERNAQFSTW 4336
L L+++G + +S + + +P W ++++ S+ L WF +LL R + TW
Sbjct: 4312 QLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTW 4371
Query: 4337 IFE-GRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPG 4395
+ P V W++GFFNPQ FLTA+ Q + R ++ W LD + +V ++TKE+ PP
Sbjct: 4372 TQDLTLPAVVWLSGFFNPQSFLTAIMQTMARKNE-WPLDKTRLTADVTKKTKEDYGHPPR 4430
Query: 4396 EGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKK 4455
EG Y++GL+M+GA WD + G ++E+ K L +PV+ A + + Y CP+Y+
Sbjct: 4431 EGAYLHGLFMEGARWDTQAGTIVEARLKELACPMPVIFAKATPVDRQETKQTYECPVYRT 4490
Query: 4456 PRRTDLTFITVVYLRTVLSPDHWILRGVALLCD 4488
R ++I L++ W+L GVALL +
Sbjct: 4491 KLRGP-SYIWTFRLKSEEKTAKWVLAGVALLLE 4522
Score = 156 bits (395), Expect = 4e-37
Identities = 156/694 (22%), Positives = 293/694 (42%), Gaps = 41/694 (5%)
Query: 19 IFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLANIFLPAVLATNNWGALNQS 78
+ F+ + +I V + LF L A L + L I +P + NN + +
Sbjct: 126 LVFISKKITESIGVNDFSQVVLFGELPALS--LGHVSAFLDEILVPVLSNKNNHKSWSCF 183
Query: 79 KQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNFSKLHTFEEVTAAASNSET 138
+ E HI E + + + G ++S + + T+ E ++
Sbjct: 184 TSQDMEYHI--EVMKKKMYIFRG-KMSRRTLLPIPTVAG-KMDLDQNCSENKPPSNERII 239
Query: 139 VHQLEEVLMVWYKQIEQVLIESEQMRKEAG-DSGPLTELEHWKRMSAKFNYIIEQIKGPS 197
+H +E V++ W QI++++ R G P EL+ W + I +Q++ P
Sbjct: 240 LHAIESVVIEWSHQIQEIIERDSVQRLLNGLHLSPQAELDFWMMRRENLSCIYDQLQAPV 299
Query: 198 CKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTLEKVCQPLYNHDLVSMAH 257
++ +L S +D+ + + E++D YL L + Q L +
Sbjct: 300 VLKMVKILTTKQSSYFPTLKDIFLAVENALLEAQDVELYLRPLRRHIQCLQETEFPQTRI 359
Query: 258 GIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAYITDGGLNHVWDQETPVV 317
I L + I +I S++YNT R+ L + N + AY++ L +E+
Sbjct: 360 LIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQATAYLSPEDLLRGEIEES--- 416
Query: 318 LKKIQDCIFLFKEYQASFHKTR-KLISESSGEK--SFEVSEMYIFGKFEAFCKRLEKITE 374
L+K+Q + + K ++ SF R KL S G K ++ +F +F+ F RL KI +
Sbjct: 417 LEKVQVAVNILKTFKNSFFNYRKKLASYFMGRKLRPWDFQSHLVFCRFDKFLDRLIKIED 476
Query: 375 MITVVQTYSTLSNSTIEG---------IDIMAIKFRNIYQGVKKKQYDILDPRRTEFDTD 425
+ + L G + M+ + + + K+ YD D EF++D
Sbjct: 477 IFATTLEFEKLERLEFGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESD 536
Query: 426 FLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQK-LNIPCLGLEINHTIERIL 484
++ F +K + ++ + +F + A +LL F L P + + ++
Sbjct: 537 YVAFKSKTLEFDRRLGTIICEAFFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLV 596
Query: 485 QYYVAELDATKKLYHSQKDD-----PPLARNMPPIAGKILWVRQLYRRIS------EPIN 533
+ ELD K+LY+ L +NMP +G + W +Q+ +R+ +
Sbjct: 597 HMFNTELDVCKQLYNEHMKQIECGHVVLNKNMPFTSGNMKWAQQVLQRLQMFWSNFASLR 656
Query: 534 YFFKNSDILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQL-HYALQATLFVRHP 592
Y F L +PD V ++Y +++ +L +FE + W + ++ + L L
Sbjct: 657 YLF-----LGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPLVKFSA 711
Query: 593 ETGKLLVNFDPKILEVVRETKCMIKM-KLDVPEQAKRLLKLESKLKADKLYLQGLLQYYD 651
G L VNFDPK++ V+RE K ++ + K D+P+ A + K + + L L+Q Y+
Sbjct: 712 INGLLCVNFDPKLVAVLREVKYLLMLKKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYN 771
Query: 652 ELCQEVPSVFVNLMTPKMKKVESVLRQGLTVLTW 685
+L Q + V L+ +++ ++ L T LTW
Sbjct: 772 KLKQTLLEVEYPLIEDELRAIDEQLTAATTWLTW 805
>gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]
Length = 4116
Score = 1821 bits (4718), Expect = 0.0
Identities = 1133/3335 (33%), Positives = 1776/3335 (53%), Gaps = 182/3335 (5%)
Query: 1273 KELNLLQKLYGLYDTVMSSISGY--YEILWGD------------------VDIEKINAEL 1312
KE LL+K Y + + + YE LW ++ E+I E+
Sbjct: 844 KEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEI 903
Query: 1313 LEFQNRCRKLPKGLKDWQA----FLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISEL 1368
KL K L D A ++K +ID F + P+L + N MK RHW +ISE+
Sbjct: 904 GNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEI 963
Query: 1369 TGTPFDVE-SDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLS 1427
G ++++ +++ CL N++E K + +E I +A KE +E L ++ +W N S
Sbjct: 964 VG--YEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFS 1021
Query: 1428 FAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDI 1487
F ++ +L + +I L++D ++ ++ + + P + + W KL D
Sbjct: 1022 FVKYRDTDTNILCAID--DIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDN 1079
Query: 1488 IEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVG 1547
++ WL Q W+YLE +F DI Q+P+E ++F +D W +M +A ++ N I
Sbjct: 1080 LDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKD-NRILVAAD 1138
Query: 1548 DETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPH 1607
M + L + LE QK L YLEKKRL FPRFFF+S+ LLEIL + D +QPH
Sbjct: 1139 QPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPH 1198
Query: 1608 LPAVSDNINEVTFHAKDYDRIMAVISREGEKIVLDNSVM---AKGPVEIWLLDLLKMQMS 1664
L + I ++ F D I+ +IS E E + + AKG VE WL + +M ++
Sbjct: 1199 LKKCFEGIAKLEF--TDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLA 1256
Query: 1665 SLHNIIR---SAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKI 1721
S+ +I A+ ++ + + L +P QV + + WT + +AL
Sbjct: 1257 SMREVIGLGIEAYVKVPRNHWVL-----QWPGQVVICVSSIFWTQEVSQALA-------- 1303
Query: 1722 MQVTNQKFLDILNTLISQTTH----DLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSP 1777
+ T FL N I+Q LS R+ L I VH RD+ L + +
Sbjct: 1304 -ENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDL 1362
Query: 1778 TDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALG 1837
DF+W+ Q R+Y+ Q V I + +Y E+LG + RLVITPLTDRCY TL AL
Sbjct: 1363 NDFQWISQLRYYWVAKDVQ--VQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALK 1420
Query: 1838 MNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCF 1897
+N+GGAP GPAGTGKTETTKD+ + L K VVFNCSD +D++ +G+ FKGLAQ+G+W CF
Sbjct: 1421 LNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACF 1480
Query: 1898 DEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQ 1957
DEFNRIE+ VLSV AQQI + A + K FIF +G + LNP +F+TMNPGYAGR
Sbjct: 1481 DEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIF-EGTELSLNPTCAVFITMNPGYAGRA 1539
Query: 1958 ELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHY 2017
ELP+NLK FRTVAMMVPD +I + L S GFL++ LAQK Y+LC EQL+ Q HY
Sbjct: 1540 ELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHY 1599
Query: 2018 DFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPG 2077
D+G+R + SVL G+ K PE++E +++R L D+NL+K + +D PLF +I+DLFPG
Sbjct: 1600 DYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPG 1659
Query: 2078 LQLDSNTYAELQNAVAHQVQIEGLINHPPWNL-KLVQLYETSLVRHGLMTLGPSGSGKTT 2136
+ L Y + ++ + + PW + K++Q+YE LVRHG M +G GKT+
Sbjct: 1660 VVLPKPDYEVFLKVLNDNIK-KMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTS 1718
Query: 2137 VITILMKAQTECGRPHREMRM----------NPKAITAPQMFGRLDTATNDWTDGIFSTL 2186
+L A G H +M NPKAIT Q++G D +++W DG+ +
Sbjct: 1719 AYKVLAAA---LGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANA 1775
Query: 2187 WRKTLKAKKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVH 2246
+R+ + + ++I DGPVDAIWIEN+N+VLDDNK L L +G+ I M L+FE
Sbjct: 1776 FREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPA 1835
Query: 2247 NIENASPATVSRMGMVYISSSALSWRPILQAWLKKRTAQEAAVFLTLYEKVFEDTYTYMK 2306
++E ASPATVSR GM+Y+ L W+P+ +++ + ++++ D + ++
Sbjct: 1836 DLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSS----LTKEHKELVNDMFMWL- 1890
Query: 2307 LNLNPKMQL--LECNYIVQSL-------------NLLEGLIPSKEEG-----GVSCVE-- 2344
+ P ++ L C ++VQ+ +LL+ + +EE G+S +
Sbjct: 1891 --VQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIF 1948
Query: 2345 -HLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLD----LPEIPKGSNQ------- 2392
L LF+F L+W++ + +SR+K + F R +D P+ K +
Sbjct: 1949 LWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERG 2008
Query: 2393 TMYEFYVTDY--GDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHK 2450
++Y+FY G WE W + + + + S +++P ++ R +F + T
Sbjct: 2009 SIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEI 2068
Query: 2451 AVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTY 2510
+L G GT K+ + +L L +NFS+ T Q I S +D+R +
Sbjct: 2069 PMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLF 2128
Query: 2511 GPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIA 2570
GPP G+K VF+DD+NMP +G Q E++RQ ++ G + K IVD+ L+
Sbjct: 2129 GPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWID-HGYWFDKKDTTRLDIVDMLLVT 2187
Query: 2571 AMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIV 2630
AM PGGGRNDI R R + + + + KIF I +F + F
Sbjct: 2188 AMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFG--KGFDVMFLRYGK 2245
Query: 2631 NLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKH 2690
LV + +++ LPTPSK HY+FNLRD SR+ QG+L + + L+ H
Sbjct: 2246 MLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIH 2305
Query: 2691 ECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCIL----PEPYFVD------FLR 2740
E RV DR I ED Q F ++ + N +L P VD F
Sbjct: 2306 EVYRVFYDRLIDKEDRQVF-FNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFG 2364
Query: 2741 EMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMT 2800
+ +P D+ KIY+ + L ++ Y +FN I + + LV F+ A+
Sbjct: 2365 DYFKPESDQ---------KIYDEITDLKQLTVVMEHYLEEFNNISKAP-MSLVMFRFAIE 2414
Query: 2801 HLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLK 2860
H+ +I R+++ G+ LLVG+GGSG+QS ++L++F+ Y+++QI +T++Y + +DLK
Sbjct: 2415 HISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLK 2474
Query: 2861 ALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVM 2920
+ G K F+F D++IKDE+F+E +N LL++G++ N+F DE +I + + +
Sbjct: 2475 KIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAA 2534
Query: 2921 KRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSR 2980
+ + + T ++Y +FI R + L SP+G+ FR R FP LI+ CT+DWF
Sbjct: 2535 RTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQS 2594
Query: 2981 WPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPK 3040
WP +AL VA+ FL D + I+ +VV F + V + Y+ + RR +VTP
Sbjct: 2595 WPTDALELVANKFLEDVEL--DDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPT 2652
Query: 3041 SYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASI 3100
SYL I +K + K + + R GL KL A+ VA + ++L + +L + S
Sbjct: 2653 SYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSE 2712
Query: 3101 KADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEA 3160
+ +++ ++ + + K VQ + +A K + E L A PALE A A
Sbjct: 2713 ETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALA 2772
Query: 3161 ALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKS--CCKPSWGESL 3218
AL+T+ P DI+ V+ + PP + +M+ + ++ K + DP S + WG S
Sbjct: 2773 ALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKP-DPSGSGKMIEDYWGVSK 2831
Query: 3219 KLMSATGFLWSLQQFPKDTINEETVELLQPYF-NMDDYTFESAKKVCGNVAGLLSWTLAM 3277
K++ FL SL+ + KD I T++ ++ F N ++ K V GL W AM
Sbjct: 2832 KILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAM 2891
Query: 3278 AIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKM 3337
++ + + V P + L + EG+LA +L + +A L L + F+ +K
Sbjct: 2892 EVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKK 2951
Query: 3338 DLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGP 3397
DL + + C +K+ A LI GL GEK RWT+ +++ + L GD+LL +G ++YLG
Sbjct: 2952 DLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGA 3011
Query: 3398 FNQIFRNYLLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGI 3457
F +R ++QW E + + IP + +L L DP I W + GLP D SI NGI
Sbjct: 3012 FTVDYR-VQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGI 3070
Query: 3458 IVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDI 3517
IV+ + R+ L+IDP Q WIK+ EK N L V + + LE++L LG P+LIE+I
Sbjct: 3071 IVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENI 3130
Query: 3518 HEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTS 3577
EELD +++ +L K K +++G+ + FKLYITT+L NP + PE+ K
Sbjct: 3131 GEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVC 3190
Query: 3578 VIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATK 3637
+++F +T GL++QLL V EK ELE ++ +L+ + NK+ +KE+ED +L LS +K
Sbjct: 3191 LLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSK 3250
Query: 3638 GSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITE 3697
G++++DE+ I VL ++K + E+SEK VA+ TE +I+ + ++P A + ++F I++
Sbjct: 3251 GNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISD 3310
Query: 3698 MSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHK 3757
++ + MYQ SL F+ L+ S+ S KS RI II++ T ++ R L+E K
Sbjct: 3311 LANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDK 3370
Query: 3758 FLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKL 3817
LF LL+T+ I Q+ + + L+ GG ALD P P +W+ + W +V S L
Sbjct: 3371 LLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAP-QWLSEKAWAEIVRASAL 3429
Query: 3818 PQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQA 3877
P+ +M + +N WK +D P EE +P + S K++++R PD+ V
Sbjct: 3430 PKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFS-QGLEKMVILRCLRPDKMVPAV 3488
Query: 3878 RKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKL---E 3934
R++IA+ + + Y E +L+ ++ +S PLI LS +DP + A L +
Sbjct: 3489 REFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTR 3548
Query: 3935 CRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFM---EELLETLITTEASDDSF 3991
+TIS+GQGQ A K+I +++ G WV+LQNCHL +M E++ E +I E+++ F
Sbjct: 3549 TQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARF 3608
Query: 3992 RVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLD------ISNLPM 4045
R+W+T+ P ++FP+++LQ +K TNEPP+G+RA L R++ +N + D + M
Sbjct: 3609 RLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSY--LNDPISDPVFFQSCAKAVM 3666
Query: 4046 WKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGVSWN 4105
W+ ML+ + F H+ VQERR FGPLGWNIPYEFN +D S+ IQ L++ K V ++
Sbjct: 3667 WQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLND---YKEVPFD 3723
Query: 4106 TVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTG--YKIPLCKTLDQY 4163
+ Y+ GE YGGRVTDD D+RLL +++ +++ E + G Y IP + Y
Sbjct: 3724 ALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSY 3783
Query: 4164 FEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGGGVGETREAIVYR 4223
+Y+++LP +PEVFGLH NADIT + + + E + P++SGG G++ + +V
Sbjct: 3784 IDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGS-GKSPQEVVEE 3842
Query: 4224 LSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAI 4283
L++D+LSKLP D+ EV +L + + SMN LRQE+ R R+ ++R SL +L AI
Sbjct: 3843 LAQDILSKLPRDFDLEEV-MKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAI 3901
Query: 4284 EGTIIMSENLRDALDNMYDARIPQLWKRVSWDS-STLGFWFTELLERNAQFSTWIFEGRP 4342
+G ++MS L + ++M ++P +W S+ S LG + +LL R F WI +G P
Sbjct: 3902 KGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPP 3961
Query: 4343 NVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYG 4402
VFW++GF+ Q FLT + Q R + +D + EV Q + + + P +G YI G
Sbjct: 3962 VVFWISGFYFTQSFLTGVSQNYARKYT-IPIDHIGFEFEVTPQ-ETVMENNPEDGAYIKG 4019
Query: 4403 LYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRT--- 4459
L+++GA WDR+ ++ ES PK+L+ LP++ + S +YVCP+YK R
Sbjct: 4020 LFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTL 4079
Query: 4460 -----DLTFITVVYLRTVLSPDHWILRGVALLCDI 4489
++ + L T + HWI RGVA LC +
Sbjct: 4080 STTGHSTNYVLSIELPTDMPQKHWINRGVASLCQL 4114
>gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]
Length = 4646
Score = 1299 bits (3361), Expect = 0.0
Identities = 961/3522 (27%), Positives = 1700/3522 (48%), Gaps = 300/3522 (8%)
Query: 1166 DTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNI 1225
D +R + +Q + ++Q +VQ +VE D++ +E P+ N+
Sbjct: 1223 DIMRRKDSAIQQQVANLQMKIVQED--------RAVESRTTDLLT---DWEKTKPVTGNL 1271
Query: 1226 PPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNL----LQKL 1281
P+EA L I++ F L + ++ L +TD +L + + + + LQ L
Sbjct: 1272 RPEEALQALTIYEGKFGRLKDDREKCAKAKE--ALELTDTGLLSGSEERVQVALEELQDL 1329
Query: 1282 YGLYDT---VMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKR 1338
G++ V I E W V K+ L N+ + P L+ + ++ +++
Sbjct: 1330 KGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRL 1389
Query: 1339 IDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIE 1398
+ + + L+ + ++A+K RHW ++ + + V L I + L K++ ++
Sbjct: 1390 LKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSE--LTLGQIWDVDLQKNEAIVK 1447
Query: 1399 DICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVL 1458
D+ + A E +E L Q+ E W L ++ K L+ +G + ++ +++ + +
Sbjct: 1448 DVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLI-RGWD--DLFNKVKEHINSV 1504
Query: 1459 GSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGG-DIAKQLPQE 1517
++ + Y F+++ +W KL+ + + W+ VQ WVYLE +F G DI LP E
Sbjct: 1505 SAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVE 1564
Query: 1518 AKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKR 1577
+RFQ+I ++ +M++ ++P V++ + + + + L L + L QK+L YLE++R
Sbjct: 1565 TQRFQSISTEFLALMKKVSKSPLVMDV-LNIQGVQRSLERLADLLGKIQKALGEYLERER 1623
Query: 1578 LLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDRIMAVISREGE 1637
FPRF+FV D LLEI+G + + +Q H + ++ + + +D ++ + SREGE
Sbjct: 1624 SSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILN-EDNSVVLGISSREGE 1682
Query: 1638 KIVLDN--SVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQL-------LPFL 1688
+++ S+ + WL + K +L ++ + ++ G + ++
Sbjct: 1683 EVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWI 1742
Query: 1689 SHFPAQVGLLGIQMLWTHDSEEALRN--AKDDRKIMQVTNQKFLDILNTLISQTTHDLSK 1746
+ AQ+ +L Q+ W+ + E AL + D + LN L +
Sbjct: 1743 DKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQPP 1802
Query: 1747 FDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFK----EDLDQTVVSIT 1802
R K E LIT VHQRD+ L+K I + FEWL Q RFYF + L Q + +
Sbjct: 1803 LRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMA 1862
Query: 1803 DVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRC 1862
+ F Y E+LG D+LV TPLTDRCY+T+ QAL +GG+P GPAGTGKTE+ K +G
Sbjct: 1863 NAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQ 1922
Query: 1863 LGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTAR 1922
LG++V+VFNC + DF+ +GRIF GL Q G+WGCFDEFNR+E +LS +QQ+ + A
Sbjct: 1923 LGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEAL 1982
Query: 1923 KERKKQFIFSDG---DC------VDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMM 1973
+E C V ++P+ IF+TMNPGYAGR LP+NLK FR++AM
Sbjct: 1983 REHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMT 2042
Query: 1974 VPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGS 2033
PDRQ+I +V L S GF +LA K +KLC+EQL+ Q HYDFGLR + SVL + G+
Sbjct: 2043 KPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGN 2102
Query: 2034 QKRARPED---------------------SELSIVMRGLRDMNLSKLVDEDEPLFLSLIN 2072
KR R + E I+++ + + + KLV ED PL SL++
Sbjct: 2103 VKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLS 2162
Query: 2073 DLFPGLQLDSNTYAELQNAVAHQVQI------EGLINHPPWNLKLVQLYETSLVRHGLMT 2126
D+FPG+Q L+ + Q +G W K++QLY+ + + HGLM
Sbjct: 2163 DVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMM 2222
Query: 2127 LGPSGSGKTTVITILMKAQTEC-GRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFST 2185
+GPSGSGK+ +L+KA G ++PKAI+ ++G LD T +WTDG+F+
Sbjct: 2223 VGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTH 2282
Query: 2186 LWRKTLKAKKGE---NIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLL 2242
+ RK + + +GE +++ DG VD W+ENLNSVLDDNK LTL NG+R+ + P+ +++
Sbjct: 2283 VLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIM 2342
Query: 2243 FEVHNIENASPATVSRMGMVYISSSALSWRPILQAWL---------------------KK 2281
FEV +++ A+ ATVSR GMV+ S LS I +L K+
Sbjct: 2343 FEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKGKE 2402
Query: 2282 RTAQEAAVFL--------TLYEKVFEDTYTYMK-----LNLNPKMQLLECNYIVQSLNLL 2328
+EAA + T+ + F K L M L + ++L
Sbjct: 2403 DEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFSML 2462
Query: 2329 EGLIPSKEEGGVS------CVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLD 2382
+ + + +E L + L++++ L +SR K+ A L ++ ++
Sbjct: 2463 HQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRIT 2522
Query: 2383 LPEIPKGSNQTMYEFYVTDYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLI 2442
+P N + ++ V+ G+W W K+ T + ++VP +D +R L+
Sbjct: 2523 TVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAA-PDVVVPTLDTVRHEALL 2581
Query: 2443 DTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYV 2502
T +HK ++L G G+ KT+ + + L+ P++++ LNFSSAT P + +T + Y
Sbjct: 2582 YTWLAEHKPLVLCGPPGSGKTMTLFSALRAL-PDMEV-VGLNFSSATTPELLLKTFDHYC 2639
Query: 2503 DKR---IGSTYGPPG-GRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPG 2558
+ R G P G+ + +F D+IN+P ++++G Q +RQM+E G Y
Sbjct: 2640 EYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQ- 2698
Query: 2559 DFTTIVDVQLIAAMIHP-GGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDP 2617
+ + +Q + A P GR + R R V P AS+ +I+G
Sbjct: 2699 TWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYG--------- 2749
Query: 2618 CRSFKPQICEMIVNL------VSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGML 2671
+F + +I +L ++ V + + ++ HYI++ R+++R +G+
Sbjct: 2750 --TFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIF 2807
Query: 2672 -TIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCIL 2730
++ E + L+ ++ HE R+ DR + E+ +W +ENI + A
Sbjct: 2808 EALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRW--------TDENIDTVA----- 2854
Query: 2731 PEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFL---AEKLQFYQRQFNEIIRG 2787
L+ P + + P +Y S D++ E+L+ Y + ++
Sbjct: 2855 --------LKHFP----NIDREKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYE 2902
Query: 2788 TSLD--LVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQIT 2845
LD LV F + + H+++I RI R G+ LL+GV G+GK +LSR +++ G ++QI
Sbjct: 2903 EELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIK 2962
Query: 2846 LTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFA 2905
+ R Y + +DL+ + + +G + I FI +S + D FLE +N LL++GE+ LF
Sbjct: 2963 VHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFE 3022
Query: 2906 RDEMDEI-TQGLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSL 2964
DE + TQ K L + + LY++F S+ +NLHVV +P E + R+
Sbjct: 3023 GDEYATLMTQCKEGAQKEGLML--DSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAA 3080
Query: 2965 KFPGLISGCTMDWFSRWPREALIAVA------------SYFLSDYNIVCSSEI------K 3006
P L + C ++WF W EAL V +Y + DY V ++ +
Sbjct: 3081 TSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHR 3140
Query: 3007 RQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAER 3066
+V + H + ++ +R R +TP+ YL FIN Y N++ EK + EQ
Sbjct: 3141 EAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMH 3200
Query: 3067 MNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEV 3126
+N+GL K+ E + V +L +DL +K +EL V + A++ L ++ Q + K K QE+
Sbjct: 3201 LNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEI 3260
Query: 3127 KDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRI 3186
+++ K + I +++ + L+ +PA+ EA+ A+ +IK + VR +A PP +
Sbjct: 3261 QEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLA 3320
Query: 3187 MDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINEETVELL 3246
++ + LL + T D W + ++ F+ ++ F + I++ E +
Sbjct: 3321 LESICLLLGES----TTD---------WKQIRSIIMRENFIPTIVNFSAEEISDAIREKM 3367
Query: 3247 QP-YFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVAN 3305
+ Y + Y +E + ++ W +A + + + V PL+ L K E
Sbjct: 3368 KKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQ 3427
Query: 3306 AELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKI 3365
+ + + ++ + +A + + + ++ ++E + D K+ ++ L+ LS E+
Sbjct: 3428 QKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERE 3487
Query: 3366 RWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKIPFTEN 3425
RW + S+ FK Q++ + GD LL F++Y G F+Q R L W L+ I F +
Sbjct: 3488 RWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLF-TTWSHHLQQANIQFRTD 3546
Query: 3426 LNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKE 3485
+ L + W LP DDL +N I++ + RYPL+IDP Q +I ++ K+
Sbjct: 3547 IARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKD 3606
Query: 3486 NDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVG 3545
+ TS FR +LE +L G PLL++D+ E DP L+ VL + ++G + +G
Sbjct: 3607 RKITRTSFLDDAFRKNLESALRFGNPLLVQDV-ESYDPVLNPVLNREVRRTGGRVLITLG 3665
Query: 3546 DKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELE 3605
D++ D+ +F ++++T+ P F P++ ++ + ++FTVT L++Q L V+ E+ +++
Sbjct: 3666 DQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVD 3725
Query: 3606 AERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLH 3665
+R LL+ + ++++LE +LL L+ KG ++DD+++I L K+ AAEV+ K+
Sbjct: 3726 EKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVE 3785
Query: 3666 VAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARS-- 3723
++ +++ P +T S +YF + + ++ +YQ SL FL ++ + +
Sbjct: 3786 ETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPN 3845
Query: 3724 -EKSPLPQKRITNIIEYLTYEVFTYSVRG-LYENHKFLFVLLMTLKIDLQRGTVKH---- 3777
+ +R++ I + L F RG L+++H +LL +K+ +GTV
Sbjct: 3846 LKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKL---KGTVGEPTYD 3902
Query: 3778 REFQALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSW 3837
EFQ ++G + P+ ++ +V LS LP F +++ ++ +E+ + W
Sbjct: 3903 AEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEA-VVRLSCLPAFKDLIAKVQADEQ-FGIW 3960
Query: 3838 FDKDAPEEEIIPDGYNDSL------DTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTE 3891
D +P E+ +P +++ H+LLLI+++ PDR + A +++ +L E +
Sbjct: 3961 LDSSSP-EQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMS 4019
Query: 3892 PVILNLEKT---WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVH- 3947
+ L+ T E TP++ G D + ++ LA + + +I++G + +
Sbjct: 4020 IMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQ 4079
Query: 3948 ARKLIQMSMQQGGWVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITL 4007
A K I +++ G WV+L+N HL ++ +L + L + + FR+++T E + + P+ L
Sbjct: 4080 ADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQ-PHACFRLFLTMEINPKVPVNL 4138
Query: 4008 LQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDISNLPMWKPMLY-TVAFLHSTVQERRKF 4066
L+ F EPP GV+A + RTF+ I + I P + LY +A+ H+ +QER ++
Sbjct: 4139 LRAGRIFVFEPPPGVKANMLRTFSSI--PVSRICKSPNERARLYFLLAWFHAIIQERLRY 4196
Query: 4067 GPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKG--------VSWNTVRYMIGEVQYGG 4118
PLGW+ YEF +D ++ + LD D KG + W+ ++ ++ + YGG
Sbjct: 4197 APLGWSKKYEFGESDLRSACDTVDTWLD--DTAKGRQNISPDKIPWSALKTLMAQSIYGG 4254
Query: 4119 RVTDDFDKRLLNCFARVWFSEKMFEPSF---CFYTGYK---IPLCKTLDQYFEYIQSLPS 4172
RV ++FD+RLLN F F+ + F+ F C G+K +P +++ ++++ LP
Sbjct: 4255 RVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPD 4314
Query: 4173 LDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGGGV--GETREAIVYRLSEDMLS 4230
P GL NA+ + ++ + +Q E + ET + + D S
Sbjct: 4315 TQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEK----KTRTDSTS 4370
Query: 4231 KLPPDYIP--HEVKSRLI-----KMGHLNSM--NI------FLRQEIDRMQRVISILRSS 4275
P ++ H S + + HL NI F +E+ +++ +R
Sbjct: 4371 DGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQD 4430
Query: 4276 LSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSS-TLGFWFTELLERNAQF- 4333
L+D+ EG + LR ++ + +P+ W + + T+ W ++ ER Q
Sbjct: 4431 LADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQ 4490
Query: 4334 -------STWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQT 4386
S E + + G F P+ ++TA RQ V +A+ W+L+ + + V T
Sbjct: 4491 NISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQAN-SWSLEELCLEVNV---T 4546
Query: 4387 KEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST-APKDP 4445
+ + + GL + GA + N KL S + T LP+ + + T K
Sbjct: 4547 TSQGATLDACSFGVTGLKLQGATCN--NNKL--SLSNAISTALPLTQLRWVKQTNTEKKA 4602
Query: 4446 KLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLC 4487
+ P+Y R DL F + T P + RGVA+LC
Sbjct: 4603 SVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLC 4644
Score = 58.5 bits (140), Expect = 1e-07
Identities = 71/347 (20%), Positives = 154/347 (44%), Gaps = 32/347 (9%)
Query: 391 EGIDIMAIKFRNI-YQGVKKKQ-YDILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSF 448
+ D AI+ N+ Y+ VK+ D+ ++ + +I+ +E +I A +
Sbjct: 513 DAADANAIEEVNLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQL 572
Query: 449 GKILSSQQALQLLQRFQKLNI-PCLGLEINHTIERILQYYVAELDATKKLY-----HSQK 502
G ++ + ++ RF L + P + I +++Q ++++ + SQ
Sbjct: 573 GTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQSQA 632
Query: 503 DDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSDIL-----SSPDGKAVIRQYNKI 557
R++PP++G I+W +Q+ R+++ Y + D+L + +G+ + + +
Sbjct: 633 CKMSHVRDLPPVSGSIIWAKQIDRQLTA---YMKRVEDVLGKGWENHVEGQKLKQDGDSF 689
Query: 558 SYVLVEFEVVYHTAWIREISQLHYALQATLFV--------RHPETGKLLVNFDPKILEVV 609
L E+ W R++ Q + + +F R KL VNF P+I+ +
Sbjct: 690 RMKLNTQEI--FDDWARKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLS 747
Query: 610 RETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPS-VFVNLMTPK 668
+E + + + VP ++L + L ++ Y+ C++V ++L+
Sbjct: 748 KEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTISLLVAG 807
Query: 669 MKK-VESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDL 714
+KK V++++ +G+ L W S L+ + Q L +FN +K+ DL
Sbjct: 808 LKKEVQALIAEGI-ALVWESYKLDPYVQ--RLAETVFN-FQEKVDDL 850
>gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]
Length = 4314
Score = 1125 bits (2910), Expect = 0.0
Identities = 908/3553 (25%), Positives = 1638/3553 (46%), Gaps = 251/3553 (7%)
Query: 1047 QEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFINEYL 1106
+E++ L + V L ++ P+K + + LL L + + + + F+ E +
Sbjct: 894 KEVERLPSAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAM 953
Query: 1107 KKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESEAVD 1166
+ L+ + ++++ A S +++ + + + P+ + NR V E +
Sbjct: 954 EVLTIMPQSVEEIGDANLQYSKLQERKPE----ILPLFQEAEDKNRLLRTVAGGGLETIS 1009
Query: 1167 TLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIP 1226
L+ ++K + S Q + K N+ ++++ +++ F ++ P I
Sbjct: 1010 NLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIE 1069
Query: 1227 P------QEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQK 1280
+++ ++ + FDDL F L ++ + K++ +
Sbjct: 1070 TGQHNTLDKSAKLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLASSISKDIESCAQ 1129
Query: 1281 LYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFL------- 1333
++ Y+ E N + + F+ + + L +W L
Sbjct: 1130 IWAFYEEFQQGFQ------------EMANEDWITFRTKTYLFEEFLMNWHDRLRKVEEHS 1177
Query: 1334 ----DLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAP 1389
L+ +D + P+L+ + + + HW + L G P + +++
Sbjct: 1178 VMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVA 1237
Query: 1390 --LLKHKDDIEDICISAIKEKDIEAKLTQVIENW----TNQNLSFAAFKGKGELLLKGTE 1443
++ D++D+ A E I L + ++ W + + + + L+K +
Sbjct: 1238 DTIVAKAADLKDLNSRAQGEVTIREALRE-LDLWGVGAVFTLIDYEDSQSRTMKLIKDWK 1296
Query: 1444 SGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEA 1503
+I+ + D+ +L SL + Y F+ + W KL+ + ++ +Q WVYLE
Sbjct: 1297 --DIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEP 1354
Query: 1504 VFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLE 1563
+F G LP+E RF +D+ + IM ++ V LL L +QL+
Sbjct: 1355 IFGRG----ALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTIL-DQLQ 1409
Query: 1564 VCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAK 1623
CQKSL +LE+KR FPRF+F+ D LLEILGQ+++ IQ HL + IN V F K
Sbjct: 1410 RCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEK 1469
Query: 1624 DYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQ 1683
I A+ S EGE + N V VE WL DL +L +++ S
Sbjct: 1470 S-KHITAMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGA 1528
Query: 1684 LLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQTTHD 1743
+ P L FP+Q+ L Q+ +T D E A++ D + Q+ Q ++N L T D
Sbjct: 1529 VDPSL--FPSQILCLAEQIKFTEDVENAIK----DHSLHQIETQ----LVNKLEQYTNID 1578
Query: 1744 LSKFD---------RVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDL 1794
S D +K + LI +H D+ L ++ + + D+ W KQ RFY K D
Sbjct: 1579 TSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSD- 1637
Query: 1795 DQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTE 1854
V + D +F Y E+ G +LV TPLTD+CY+TL QA+ M +GG P GPAGTGKTE
Sbjct: 1638 HTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTE 1697
Query: 1855 TTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQ 1914
+ K +G LG+ V+VFNC + +D + +GRIF GL + G+WGCFDEFNR+E VLS + Q
Sbjct: 1698 SVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQ 1757
Query: 1915 IYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNP---GYAGRQELPENLKIQFRTVA 1971
I + A K + G V++N GIF+TMNP GY GRQ+LP+NLK FR VA
Sbjct: 1758 IQTIQDALKNHRTVCELL-GKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVA 1816
Query: 1972 MMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTL 2031
M PD ++I V L S GF + +L++K ++ L E LT Q HYD+GLR + +VLR
Sbjct: 1817 MSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGS 1876
Query: 2032 GSQKRARPED------SELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTY 2085
G+ R + +E IV++ LR +SK D F +LI D+FPG++L Y
Sbjct: 1877 GNLLRQLNKSGTTQNANESHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEY 1936
Query: 2086 AELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQ 2145
EL A+ + P K ++LYE R G++ +GPSG+GK+T+ +L A
Sbjct: 1937 DELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAAL 1996
Query: 2146 TECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDG 2205
+ G+ ++ MNPKA+ Q+ G +D T +W+DG+ + R+ ++ + + ++I DG
Sbjct: 1997 CKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDG 2056
Query: 2206 PVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYIS 2265
+D WIE+LNSVLDDN+ LT+ +G+RI P+ +FE H++ ASPAT+SRMGM+++S
Sbjct: 2057 DIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLS 2116
Query: 2266 SSALSWRPILQAWLKKRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSL 2325
++++WL+ + A+ FE ++ L ++E + + +
Sbjct: 2117 DEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQWV---LKQNDYVVETSLVGTVM 2173
Query: 2326 NLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLGALLELESREKL--EAFLRQHESKLDL 2383
N L L ++ H F+ L+ LG L ++SR + E F ES
Sbjct: 2174 NGLSHLHGCRD----------HDEFIINLIRGLGGNLNMKSRLEFTKEVFHWARES---- 2219
Query: 2384 PEIPKGSNQTMYEFYVTDYGDWEHWNKKLQPYYYPTDSIPEYSSILV---PNVDNIRTNF 2440
P ++ M +Y + G + K +P D ++ V P++ F
Sbjct: 2220 ---PPDFHKPMDTYYDSTRGRLATYVLK-KPEDLTADDFSNGLTLPVIQTPDMQRGLDYF 2275
Query: 2441 LIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIES 2500
+ + +L G +G K ++++ Y Q++ + T + Q+ ++
Sbjct: 2276 KPWLSSDTKQPFILVGPEGCGKGMLLR-YAFSQLRSTQIATVHCSAQTTSRHLLQKLSQT 2334
Query: 2501 --YVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPG 2558
+ G Y P ++ +++ DIN+P +++WG ++Q++ +G Y D+
Sbjct: 2335 CMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFY--DENL 2392
Query: 2559 DFTTIVDVQLIAAMIHPGG-GRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDP 2617
++ + ++Q++A+M G GR+ + R + + P + I+G Y +P
Sbjct: 2393 EWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPEREQLQTIYG----AYLEP 2448
Query: 2618 C--RSFKPQICEMIVNLVSV--GRVLWQWTKVKMLPTPSKF-HYIFNLRDLSRIWQGMLT 2672
++ K + + + G ++ + +V+ T + HY F L++ G+
Sbjct: 2449 VLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFR 2508
Query: 2673 IKAEECAS---IPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAASCI 2729
E +S + +L + +E R+ D+ + ++ F+ LT + + GSD
Sbjct: 2509 YDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILD-N 2567
Query: 2730 LPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDF---LAEKLQFYQRQFNEIIR 2786
+ + ++V + P + K + S D + + L Y R
Sbjct: 2568 MSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKGLIHYGRD------ 2621
Query: 2787 GTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITL 2846
+LD++ F + + ++ +I R++ G+ LL G G G+++++ L S + G +F +
Sbjct: 2622 NQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKI 2681
Query: 2847 TRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFAR 2906
+R Y + +DLK + ++AG + + + + D + FLE +N+LLSSGE+ L+
Sbjct: 2682 SRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTL 2741
Query: 2907 DEMDEITQGLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKF 2966
+E++ + L ++ F ++ YF R ++NLH+VL F
Sbjct: 2742 EELEPLLLPL-----KDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCESN 2796
Query: 2967 PGLISGCTMDWFSRWPREALIAVASYFLSD------YNIVCSSEIKRQVVETMGLFHD-- 3018
P L C + W W ++ + S+ YN E K++
Sbjct: 2797 PALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFL 2856
Query: 3019 MVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEAS 3078
++ ESC++Y TP Y++F++ Y I + K K + ++ + G+ KL EA
Sbjct: 2857 LIHESCKAY--------GATPSRYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAK 2908
Query: 3079 ESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEID 3138
V +L++ + L +AD L +TVS Q +++ K E++ +K + + V +I+
Sbjct: 2909 ALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIE 2968
Query: 3139 SEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKI 3198
K K + +L+ +P + EA+ A+ IKP ++ +R L PP +I I++ VL L
Sbjct: 2969 ERKNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLM---- 3024
Query: 3199 DPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINEETVELLQP--YFNMDDYT 3256
SW ++ G + F I++E E ++ + N +
Sbjct: 3025 ---------GIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKGSFD 3075
Query: 3257 FESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLD 3316
++AK+ A L +W A + + + PL+ A E L K + LL+
Sbjct: 3076 PKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLN 3135
Query: 3317 EKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKA 3376
++ +++ KF + +E L + ++ ++AA LI+ L E RW Q E
Sbjct: 3136 SVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITE 3195
Query: 3377 QINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEM-----ELRARKIPFTENLNLISM 3431
++ L L F++YL + R L ++W + R+ TE+ LI
Sbjct: 3196 ELATLPKRAQLAAAFITYLSAAPESLRKTCL-EEWTKSAGLEKFDLRRFLCTESEQLI-- 3252
Query: 3432 LVDPPTIGEWGLQGLPGDDLSIQNGIIVTK-------ATRYPLLIDPQTQGKTWIKSKEK 3484
W +GLP DDLSI+N +++ + + P LIDP +Q W+K+ K
Sbjct: 3253 ---------WKSEGLPSDDLSIENALVILQIIGLKSWSRVCPFLIDPSSQATEWLKTHLK 3303
Query: 3485 ENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKV 3544
++ L+V + F T LE ++ G+ L+I+++ + ++P L +L ++ + G + V++
Sbjct: 3304 DSRLEVINQQDSNFITALELAVRFGKTLIIQEM-DGVEPVLYPLLRRDLVAQGPRYVVQI 3362
Query: 3545 GDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQEL 3604
GDK D + F+L+++T+ PNP P+ + + ++FT T GL QLL I EK +L
Sbjct: 3363 GDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDL 3422
Query: 3605 EAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKL 3664
E ++ KLL+ K ++ +LE++LL L+ ++G++++++ LI L TK ++A + E L
Sbjct: 3423 EEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESL 3482
Query: 3665 HVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSE 3724
+ + +I ++ ++ + P A S +YF+I+++S +N MY+ SLA FL+LF +++ +
Sbjct: 3483 KESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQ 3542
Query: 3725 KSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHRE-FQAL 3783
S ++RI ++I L + V+ Y R L++ + +F L + + + F +
Sbjct: 3543 DSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGV 3602
Query: 3784 IKGGAALDLKACPPKPYR-----WI-LDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSW 3837
+ G + KA + R WI + +W LP + + + W+++
Sbjct: 3603 VVGD--MLRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTL--CFEDAALWRTY 3658
Query: 3838 FDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNL 3897
++ E+E P + ++L++++ PDR + +L K P+ LNL
Sbjct: 3659 YNNSMCEQE-FPSILAKKVSLFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNL 3717
Query: 3898 EKTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKL-EC-RTISMGQGQEVHARKLIQMS 3955
++ ++E+ P++ +S G+DP+ ++ LA + EC ++MGQGQ A ++++
Sbjct: 3718 KRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKEC 3777
Query: 3956 MQQGGWVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFT 4015
+ G W+ L+N HL + ++ +LE + T D+FR+W+T E H F LLQ+SLK T
Sbjct: 3778 ARNGDWLCLKNLHLVVSWL-PVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKIT 3836
Query: 4016 NEPPQGVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPY 4075
E P G++ L RT+ + + + L+++A+ H+ QERR + P GW Y
Sbjct: 3837 YESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFY 3896
Query: 4076 EFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARV 4135
EF+ +D A I D K V W V ++ YGGR+ + FD R+L + +
Sbjct: 3897 EFSLSDLRAGYNIIDRLFDGA---KDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQ 3953
Query: 4136 WFSEKMFE------PSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITY 4189
+F+ + + F +P ++ Y I+ +P D P FGL N +
Sbjct: 3954 FFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPANIARSS 4013
Query: 4190 QSNTASAVLETITNIQPKESGGGVGETREAIVYRLSE--DMLSKL--PPDYIPHEVKSRL 4245
Q +S V+ + I + G RE LS ++ KL + I +V
Sbjct: 4014 QRMISSQVISQL-RILGRSITAGSKFDREIWSNELSPVLNLWKKLNQNSNLIHQKVPPPN 4072
Query: 4246 IKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARI 4305
+ G + + F+ E R++ + SL+ L I GT ++S ++ + + +
Sbjct: 4073 DRQG--SPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKLASALLNQKC 4130
Query: 4306 PQLWKRVSWDSSTLGFWFTE-LLERNAQFSTWIFEGRPNVFW-----MTGFFNPQGFLTA 4359
P W+ W+ + L+ R W+ + ++ F+P FL A
Sbjct: 4131 PLAWQS-KWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNA 4189
Query: 4360 MRQEVTRAHKGWALDT---VTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGK 4416
+RQE RA G ++D+ V L++ K +I I GL ++G ++D +
Sbjct: 4190 LRQETARA-VGRSVDSLKFVASWKGRLQEAKLQIK--------ISGLLLEGCSFD--GNQ 4238
Query: 4417 LMES---TPKVLFTQLPVLHIFAINSTAPKDP-KLYVCPIYKKPRRTDLTFITVVYLRTV 4472
L E+ +P V + ++ P P + P+Y R + +T + +
Sbjct: 4239 LSENQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRV--VTNIDVPCG 4296
Query: 4473 LSPDHWILRGVAL 4485
+ D WI G AL
Sbjct: 4297 GNQDQWIQCGAAL 4309
Score = 41.2 bits (95), Expect = 0.023
Identities = 70/373 (18%), Positives = 148/373 (39%), Gaps = 37/373 (9%)
Query: 354 SEMYIFGKFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYD 413
+E Y + KRLE++ + T+ + + ++ E I + F + G+ QY+
Sbjct: 316 NEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTRVFEP-FTGLNPVQYN 374
Query: 414 -ILDPRRTEFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQK----LN 468
+P + + I E +I + + +I S Q QLLQ F K +
Sbjct: 375 PYTEPL---WKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQ--QLLQAFLKYKELVK 429
Query: 469 IPCLGLEINHTIERILQYYVAELDATKKLYHSQ-------KDDPPLARNMPPIAGKILWV 521
P + E+ E +L V + + + ++ P +N+ + I+WV
Sbjct: 430 RPTISKELMLERETLLARLVDSIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWV 489
Query: 522 RQLYRRISEPINYFFKNSDILSSPDGKAVIRQYNK-ISYVLVEFEVVYHTAWIREI---- 576
RQL ++ + I +LS G Q K + L +E W R+I
Sbjct: 490 RQLELKVDDTIKI---AEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGL 546
Query: 577 ----SQLHYALQATLFVRHPETGKLLVNFDPKILEVVRETKCMIKMKLDVPEQAKRLLKL 632
S L + + G L V++ +++ ++RE + + + +P + +++ +
Sbjct: 547 SDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANI 606
Query: 633 ESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQ------GLTVLTWS 686
K + L+ + +Y+ + Q++ +M E +++ G + +TW
Sbjct: 607 AQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWD 666
Query: 687 S-LTLESFFQEVE 698
+ LE + Q+++
Sbjct: 667 NPKELEGYIQKLQ 679
>gi|194440727 dynein heavy chain domain 2 isoform 1 [Homo sapiens]
Length = 3092
Score = 924 bits (2389), Expect = 0.0
Identities = 627/2008 (31%), Positives = 1031/2008 (51%), Gaps = 136/2008 (6%)
Query: 988 LLSSSVNSLRKAAHEALQDFQKYKTLWTEDRD--------VKVKEFLANNPSLTEIRSEI 1039
+L +V++L+ A H L+ +K+ + E + ++ F + + E I
Sbjct: 388 VLHWAVDTLKAAVHRNLEGARKHYETYVEKYNWLLDGTAVENIETFQTEDHTFDEYTEFI 447
Query: 1040 LHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMI 1099
+ + EI L I + L E +K L+ +AKA+ +L + +Y+K+ +
Sbjct: 448 EKFLSLASEIMLLPQWIHYTMVRLDCEDLKTGLTNKAKAFANILLNDIASKYRKENECIC 507
Query: 1100 A---FINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVE 1156
+ I E+ K+ ++ D+ +E + E+ + + + +Y + +V
Sbjct: 508 SEFEAIKEHALKVPETTEEMMDLISYVEKARTVGIEELILRIQESKRQMSYFL----DVF 563
Query: 1157 VTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSN--------LLESVEVFREDV 1208
+ +E A++ + + + ++L++ K N L+ +E +
Sbjct: 564 LFPQEDLALNATVLMWPRKINPIFDENDELIENAKHKKENELMAKREKLILEIEKESRRM 623
Query: 1209 INFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVL 1268
F E ELE ++ R+Q + + + ++ E+LF +T Y L
Sbjct: 624 EEFTEFAELERMQQYVTDVRQLQKRIQESEEAVQFINKE-------EELFKWELTKYPEL 676
Query: 1269 HKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKD 1328
K + + QK + S + + + D++ E + A++ EF R++ K LK
Sbjct: 677 DKLKVNIEPYQKFFNFVLKWQRSEKRWMDGGFLDLNGESMEADVEEFS---REIFKTLKF 733
Query: 1329 WQAFLDLKKRIDDFSESCPLLEMMTNKA--------------MKQRHWDRISELTGTPFD 1374
+Q LKK + + ++ + K M+ RHW +ISE+ G +D
Sbjct: 734 FQT--KLKKELQEKRKAARKRSLEEEKIEEEPKDNATITMCRMRARHWKQISEIVG--YD 789
Query: 1375 VESDS-FCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKG 1433
+ DS LR +++ L + + E I A KE +E + +I W + + ++
Sbjct: 790 LTPDSGTTLRKVLKLNLTPYLEQFEVISAGASKEFSLEKAMNTMIGTWEDIAFHISLYRD 849
Query: 1434 KGELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLV 1493
G +L + EI +++D ++ ++ + + PF+ I+ W +L + I+EWL
Sbjct: 850 TGVCILSSVD--EIQAILDDQIIKTQTMRGSPFIKPFEHEIKAWEDRLIRIQETIDEWLK 907
Query: 1494 VQNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQ 1553
VQ W+YLE +F DI +Q+P+E ++FQ +D+ W IM+ ++P V+ + +
Sbjct: 908 VQAQWLYLEPIFCSEDIMQQMPEEGRQFQTVDRHWRDIMKFCAKDPKVL-AATSLTGLLE 966
Query: 1554 LLPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSD 1613
L + +E LE K L YLEKKRL FPRFFF+S+ +LEIL + D +QPHL +
Sbjct: 967 KLQNCNELLEKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFE 1026
Query: 1614 NINEVTFHAKDYDRIMAVISREGEK---IVLDNSVMAKGPVEIWLLDLLKMQMSSLHNII 1670
I ++ F + D I A+ S EGE+ I L ++ A+G VE WL+ + + + S+H++I
Sbjct: 1027 GIAKLEF-LPNLD-IKAMYSSEGERVELIALISTSAARGAVEKWLIQVEDLMLRSVHDVI 1084
Query: 1671 RSAFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRK--IMQVTNQK 1728
+A +S + ++ +P QV L QM WT +++E + + K ++ NQ
Sbjct: 1085 AAARLAYPESARR--DWVREWPGQVVLCISQMFWTSETQEVISGGTEGLKKYYKELQNQ- 1141
Query: 1729 FLDILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRF 1788
LN ++ LSK R L+TI VH RD+ D++KM + TDF WL Q R+
Sbjct: 1142 ----LNEIVELVRGKLSKQTRTTLGALVTIDVHARDVVMDMIKMGVSHDTDFLWLAQLRY 1197
Query: 1789 YFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPA 1848
Y++ + V I + + Y E+LG + RLVITPLTDRCY TL A +N+GGAP GPA
Sbjct: 1198 YWENE--NARVRIINCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPA 1255
Query: 1849 GTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVL 1908
GTGKTETTKD+ + L VVFNCSD +D+ +G+ FKGLA SG+W CFDEFNRIEL VL
Sbjct: 1256 GTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVL 1315
Query: 1909 SVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFR 1968
SV AQQI + A +++ F+F +G + LNP + +TMNPGYAGR ELP+NLK+ FR
Sbjct: 1316 SVVAQQILCIQRAIQQKLVVFVF-EGTELKLNPNCFVAITMNPGYAGRSELPDNLKVLFR 1374
Query: 1969 TVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVL 2028
TVAMMVP+ +I + L S GFL L+ K + Y+LC EQL+ Q HYD+G+R + +VL
Sbjct: 1375 TVAMMVPNYALIAEISLYSYGFLNARPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVL 1434
Query: 2029 RTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAEL 2088
G+ K P ++E +++R ++D+N K + D PLF + +DLFPG++L Y E
Sbjct: 1435 VAAGNLKLKYPNENEDILLLRSIKDVNEPKFLSHDIPLFNGITSDLFPGIKLPEADYHEF 1494
Query: 2089 QNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQT-- 2146
+ L + K++Q YE +VRHG M +G + KT V+ +L T
Sbjct: 1495 LECAHEACNVHNLQPVKFFLEKIIQTYEMMIVRHGFMLVGEPFAAKTKVLHVLADTLTLM 1554
Query: 2147 -ECGRPHRE----MRMNPKAITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFL 2201
E G E +NPK+IT Q+FG+ D +++WTDGI + +R+ ++ + ++
Sbjct: 1555 NEHGYGEEEKVIYRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREFALSETPDRKWV 1614
Query: 2202 ILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGM 2261
+ DGP+D +WIE++N+VLDDNK L L +G+ I M+P L+FE ++ ASPATVSR GM
Sbjct: 1615 VFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSPQMSLIFETMDLSQASPATVSRCGM 1674
Query: 2262 VYISSSALSWRPILQAWLKKRTAQEAAVFLTLYEKVFEDTYTYM-KLNLNPKMQLLECNY 2320
+Y+ S L W P++ +WL + + + Y+ + + ++ +LN +++L + NY
Sbjct: 1675 IYLEPSQLGWEPLVSSWL---NSLKGPLCEPEYQALLRGLFAWLIPPSLNQRVELFQLNY 1731
Query: 2321 IVQSL--NLLEGLIPSKEEGGVSCVE------------HLHKLFVFGLMWSLGALLELES 2366
+ ++ +L+ LI + V H F+F L+WS+G + +
Sbjct: 1732 LYTTIVSKILKILITFRISNYFKYVPLKTQCTFIKFFLHQQACFIFSLIWSIGGSCDTDG 1791
Query: 2367 REKLEAFLR-------------QHESKLDLPEIPKGSNQTMYEFYVTDYGDWEHWNKKLQ 2413
R + F+R K + P KG Y + + + G W HWN+ ++
Sbjct: 1792 RRVFDTFIRLIILGKDDENPVPDSVGKWECPFDEKGLVYD-YMYELKNKGRWVHWNELIK 1850
Query: 2414 PYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKY 2473
I + I+VP +D IR FL+D K +L G GT K+V VK L +
Sbjct: 1851 NTNLGDKQI-KIQDIIVPTMDTIRYTFLMDLSITYAKPLLFVGPTGTGKSVYVKDKLMNH 1909
Query: 2474 -DPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINE 2532
+ + +N S+ T Q I + +DKR +GPP G+K +FIDD+NMP + +
Sbjct: 1910 LEKDQYFPFYINLSARTSANQVQNIIMARLDKRRKGVFGPPMGKKCIIFIDDMNMPALEK 1969
Query: 2533 WGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTV 2592
+G Q E++RQ + Y L K T+VD++LIAAM PGGGRN + R R F +
Sbjct: 1970 YGAQPPIELLRQFFDCGHWYDL-KDTSKITLVDIELIAAMGPPGGGRNPVTPRCIRHFNI 2028
Query: 2593 FNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPS 2652
+ S+ ++ +IF I ++ F P+ + +V+ +++ + +LPTP+
Sbjct: 2029 CSINSFSDETMVRIFSSI-VAFYLRTHEFPPEYFVIGNQIVNGTMEIYKQSVENLLPTPT 2087
Query: 2653 KFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAH 2712
K HY FNLRD SR+ +G L I+ + A+ T++ LF HE RV DR I +D +W
Sbjct: 2088 KSHYTFNLRDFSRVIRGCLLIERDAVANKHTMIRLFVHEVLRVFYDRLINDDDRRWL-FQ 2146
Query: 2713 LTRAVEENIGSDAASCILPE------PYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPS 2766
LT+ V ++ ++ I P + LR + GD + ++Y +P+
Sbjct: 2147 LTKTVIKDHFKESFHSIFSHLRKQNAPVTEEDLRNL--MFGDYMNPDLEGDDRVYIEIPN 2204
Query: 2767 FDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGK 2826
++ + ++N+ + T ++LV F+ + HL +I R+++ S GNALLVG+GGSG+
Sbjct: 2205 IHHFSDVVDQCLDEYNQTHK-TRMNLVIFRYVLEHLSRICRVLKQSGGNALLVGLGGSGR 2263
Query: 2827 QSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKD-E 2885
QSL+RLA+ +A IFQ +++SY + +D+K+ V +T D++ K E
Sbjct: 2264 QSLTRLATSMAKMHIFQPEISKSYGMNEWREDMKSFIAVP------VTNRIVDNKSKILE 2317
Query: 2886 AFLEYLNNLLSSGEISN----LFARDEM 2909
L YLN+ + N LF +D++
Sbjct: 2318 KRLRYLNDHFTYNLYCNICRSLFEKDKL 2345
Score = 451 bits (1160), Expect = e-126
Identities = 262/794 (32%), Positives = 419/794 (52%), Gaps = 44/794 (5%)
Query: 3725 KSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALI 3784
KS + +KR+ + ++ TY ++ R L+E K LF L+ + L R ++++E L+
Sbjct: 2312 KSKILEKRLRYLNDHFTYNLYCNICRSLFEKDKLLFSFLLCANLLLARKEIEYQELMFLL 2371
Query: 3785 KGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPE 3844
GG +L P P W+ D +W + S+ P F + + W+ +D P
Sbjct: 2372 TGGVSLKSAEKNPDP-TWLQDKSWEEICRASEFPAFRGLRQHFCEHIYEWREIYDSKEPH 2430
Query: 3845 EEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEES 3904
P + +L+ K++++R PD+ Y+ D L +K+ EP +L K++ +S
Sbjct: 2431 NAKFPAPMDKNLNELQKIIILRCLRPDKITPAITNYVTDKLGKKFVEPPPFDLTKSYLDS 2490
Query: 3905 DTRTPLICFLSMGSDPTNQIDALAKKLKL---ECRTISMGQGQEVHARKLIQMSMQQGGW 3961
+ PLI LS G+DP + A + + + IS+GQGQ A K+I+ ++++G W
Sbjct: 2491 NCTIPLIFVLSPGADPMASLLKFANDKSMSGNKFQAISLGQGQGPIAAKMIKAAIEEGTW 2550
Query: 3962 VLLQNCHLGLEFM---EELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEP 4018
V LQNCHL + +M E++ E T+E + SFR+W+T+ P +FP+T+LQ +K TNEP
Sbjct: 2551 VCLQNCHLAVSWMPMLEKICED-FTSETCNSSFRLWLTSYPSSKFPVTILQNGVKMTNEP 2609
Query: 4019 PQGVRAGLKRTFAGINQDLLDISNLP-----------MWKPMLYTVAFLHSTVQERRKFG 4067
P G+R L +++ L D + P W+ +L+ V F H+ VQER+KFG
Sbjct: 2610 PTGLRLNLLQSY------LTDPVSDPEFFKGCRGKELAWEKLLFGVCFFHALVQERKKFG 2663
Query: 4068 PLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKR 4127
PLGWNIPY FN +D S++ +Q ++E D + + + Y+ GE YGGRVTDD+D+R
Sbjct: 2664 PLGWNIPYGFNESDLRISIRQLQLFINEYDT---IPFEAISYLTGECNYGGRVTDDWDRR 2720
Query: 4128 LLNCFARVWFSEKMFE-PSFCFYT--GYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPN 4184
LL +++ + E P + F Y P T + Y E+I+ LP +PE+FGLH N
Sbjct: 2721 LLLTMLADFYNLYIVENPHYKFSPSGNYFAPPKGTYEDYIEFIKKLPFTQHPEIFGLHEN 2780
Query: 4185 ADITYQSNTASAVLETITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSR 4244
DI+ + E++ Q G + + I+ +++D+L+KLP D+ E+ R
Sbjct: 2781 VDISKDLQQTKTLFESLLLTQGGSKQTGASGSTDQILLEITKDILNKLPSDF-DIEMALR 2839
Query: 4245 LIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDAR 4304
+ + SMN L QE++R +I +R++L DL+ AI+G ++M L ++ +
Sbjct: 2840 KYPVRYEESMNTVLVQEMERFNNLIITIRNTLRDLEKAIKGVVVMDSALEALSGSLLVGK 2899
Query: 4305 IPQLWKRVSWDS-STLGFWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQE 4363
+P++W + S+ S LG + T+ L R W G+P VFW++GFF Q FLT Q
Sbjct: 2900 VPEIWAKRSYPSLKPLGSYITDFLARLNFLQDWYNSGKPCVFWLSGFFFTQAFLTGAMQN 2959
Query: 4364 VTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPK 4423
R + +D + EV+ + + P +GVYI+GLY+DGA WDR +G L E PK
Sbjct: 2960 YARKYT-TPIDLLGYEFEVIPSDTSD--TSPEDGVYIHGLYLDGARWDRESGLLAEQYPK 3016
Query: 4424 VLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRT--------DLTFITVVYLRTVLSP 4475
+LF +P++ I + YVCP+YK R F+ + L+T
Sbjct: 3017 LLFDLMPIIWIKPTQKSRIIKSDAYVCPLYKTSERKGTLSTTGHSTNFVIAMLLKTDQPT 3076
Query: 4476 DHWILRGVALLCDI 4489
HWI RGVALLC +
Sbjct: 3077 RHWIKRGVALLCQL 3090
>gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [Homo
sapiens]
Length = 4515
Score = 760 bits (1963), Expect = 0.0
Identities = 506/1888 (26%), Positives = 896/1888 (47%), Gaps = 235/1888 (12%)
Query: 2807 RIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVA 2866
R++ N +G+ G GK++ + LA ++ +++++ ++ + K ++ A
Sbjct: 2653 RLLSRELENCFQIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHA 2712
Query: 2867 GADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPR 2926
G GK + + I+ ++FLE LN ++SSG I +LF E+D I + + ++
Sbjct: 2713 GLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQS--G 2770
Query: 2927 HPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREAL 2986
H +L +F R KNLH+ + SP G FR +P +IS CT+DW+ RWP EAL
Sbjct: 2771 HMDNRQSLLSFFQKRIYKNLHIFVIMSPEGPSFRQNCRVYPSMISSCTIDWYERWPEEAL 2830
Query: 2987 IAVASYFLSD-YNIVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSF 3045
+ VA+ FL + N +K ++ T H + + YF+ R + TP SYL F
Sbjct: 2831 LIVANSFLKEKVNFENRENLKEKLAPTCVQIHKSMKDLNRKYFEETGRFYYTTPNSYLQF 2890
Query: 3046 INGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEV 3105
+ + +I + + + + +R ++GL ++EA+ V ++ ++L + ++ + + + +
Sbjct: 2891 METFAHILRAREEEMQTKRDRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETL 2950
Query: 3106 LAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTI 3165
+ ++ +Q K++ V++ ++ + V ++ K ++L++ PA ++A ALN +
Sbjct: 2951 MEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIVALNAL 3010
Query: 3166 KPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATG 3225
D+A +R +PP L++ +M+ V +L QKK P+W + L+S TG
Sbjct: 3011 DKADVAELRVYTRPPFLVLTVMNAVCILLQKK--------------PNWATAKLLLSETG 3056
Query: 3226 FLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINR 3285
FL L KD+I ++ L+ + D+ V L W +A+ ++ + +
Sbjct: 3057 FLKKLINLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQK 3116
Query: 3286 EVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADT 3345
V P + +A+ + L +A L + Q L + L +QA + + EK L N
Sbjct: 3117 VVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTM 3176
Query: 3346 CRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNY 3405
++ Q AS L+ L EK RW + + ++ ++GDILL + Y G FR
Sbjct: 3177 ASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQ- 3235
Query: 3406 LLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRY 3465
L+ ++WE I + +LI ++ I W QGLP S++N I++ ++
Sbjct: 3236 LIVNKWETFCIENGISLSSKFSLIKVMAQKYEISRWHNQGLPHGQYSVENAILIKNGQQW 3295
Query: 3466 PLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPAL 3525
PLLIDP Q WI+ E LQ S+ + +E+++ G +L++++ E L P L
Sbjct: 3296 PLLIDPHRQAHKWIRQMEGSR-LQKLSIEDSNYTKKIENAMKTGGSVLLQNLLETLAPGL 3354
Query: 3526 DNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTM 3585
+L+K+ + + ++VGD E + F+LY++T++ NP F P + ++I+FTVT
Sbjct: 3355 KAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIDNPHFLPSVYNFVTMINFTVTF 3414
Query: 3586 KGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDES 3645
+GL++QLL V+ E LE +R KLLE ++ + ++ELE+ L L GS++DD+
Sbjct: 3415 QGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDK 3474
Query: 3646 LIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMY 3705
++ LR +K T+ E+S+++ + E +I A ++ + P ATRG++LYFL+ +++ +N MY
Sbjct: 3475 IVDTLRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMY 3534
Query: 3706 QTSLAQFLKLF-----------DQSMARSEKSP--------------------LPQKRIT 3734
Q SL F ++F + S R + SP L K I
Sbjct: 3535 QFSLDWFHQVFVSSVVSKSKEQEHSFKREKVSPKEVHEFISISKEPNLENEKNLLDKHIK 3594
Query: 3735 NIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQR----------GTVKHREFQALI 3784
+ I+ LT +F L+ K F + I G + E+ +
Sbjct: 3595 SAIDMLTKSIFKVVSSALFNEDKLCFSFRLCTVIMQNNANGNLIQDDIGFLPEEEWNIFL 3654
Query: 3785 KGGAALDLKAC-------------PPKPYRWILDMTWLNLVELSK-LPQFAEIMNQISRN 3830
G +++K+ + +W+ D W +S L F+ + + N
Sbjct: 3655 YSGILINIKSALSQSRLTSTFEIGESQHLQWLSDSRWRQCQYVSTHLEPFSLLCKSLLSN 3714
Query: 3831 EKGWKSWFDKDAP---------------EEEIIP----DGYNDSLDTCH----------- 3860
W ++ + A EE P + N++ +TC+
Sbjct: 3715 VSQWDTFKNSKAVYSLISTPFSSENASLEENTKPPEETELLNENKETCNPINFPWEKLTS 3774
Query: 3861 --KLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGS 3918
+L+L++ P+ RK+I + + KY + +NL+ ++ S+ RTPLI + G
Sbjct: 3775 FQRLILVKVLRPESLNNSVRKFITEKMGNKYLQRTGVNLKDAYKGSNARTPLILIQTHGI 3834
Query: 3919 DPTNQIDALAKKLK---LECRTISMGQGQEVHARKLIQMSMQQGG-WVLLQNCHLGLEFM 3974
D TN + A++LK IS+G+ Q A LI ++ + WV LQNCHL FM
Sbjct: 3835 DLTNILLRFAQELKGTTHHVTIISLGRDQAAKAEDLILKALTKTQQWVFLQNCHLATSFM 3894
Query: 3975 EELLETLITTEAS-----DDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRT 4029
L T++ + S D FR+W++++ + FPI +L+ LK E PQG+++ L +T
Sbjct: 3895 PRLC-TIVESFNSPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKIAVESPQGLKSNLLQT 3953
Query: 4030 FA--GINQDLLDISNLP----MWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFS 4083
F G + +I P WK +L+++ F ++ + ER+ +G LGWNI Y+FNS+D
Sbjct: 3954 FGCTGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLG 4013
Query: 4084 ASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFE 4143
+++ ++N L + +SW +RY+IGEV YGGRV D++DKR L + + ++ +
Sbjct: 4014 VAIKVLENSLRG---QPSISWQALRYLIGEVIYGGRVIDNWDKRCLKTLLYKFCNPEVLK 4070
Query: 4144 PSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITN 4203
F F ++ Y IQSLP D PEV G+HP A + +E +
Sbjct: 4071 DDFSFSRS------ASIKDYIHIIQSLPDDDLPEVLGIHPEAIRSCWETQGEKFIENLIA 4124
Query: 4204 IQPKESGGGV----GETREAIVYRLSEDMLSKLP------------PDYIPHEVKSRLIK 4247
+QPK + + ++++ +V + D+L +LP P + + S + +
Sbjct: 4125 MQPKTTTANLMIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPSTLKSMMSSSIWE 4184
Query: 4248 MGHLNSMN----------IFLRQEIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDAL 4297
N + FL+QEI R +++ ++ SL DL+LAI+G II+++ L +
Sbjct: 4185 SLSKNLKDHDPLIHCVLLTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIF 4244
Query: 4298 DNMYDARIPQLWKRVSWDS-STLGFWFTELLERNAQFSTW-------------------- 4336
++ + R+P LW++ ++ S L W +L++R F+TW
Sbjct: 4245 NSFLNMRVPTLWQKHAYRSCKPLSSWIDDLIQRLNFFNTWAKVAYTAIQRRYMRFVTVWK 4304
Query: 4337 -------------------IFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVT 4377
FEG P+ +W+ FF PQ FL A+ Q+ R+ +G A+D +T
Sbjct: 4305 QSIPSTSQKCKHPEDSENNFFEGFPSRYWLPAFFFPQAFLAAVLQDYGRS-RGIAVDALT 4363
Query: 4378 IHNEVLRQTKEEI--------------------TSPPGEGVYIYGLYMDGAAWDRRNGKL 4417
+ V+ T ++ ++ GVYI+GL+++GA W+R L
Sbjct: 4364 FTHHVISNTTDKDEKFSVFMPKKLNIVRRAFKGSASSHTGVYIFGLFIEGARWNREQKIL 4423
Query: 4418 MESTPKVLFTQLPVLHIFAI-------NSTAPKDPKLYV--CPIYKKPRRTDL------- 4461
+S P + P ++ N++ D +LY CP+Y+ P R+ +
Sbjct: 4424 EDSLPLEMCCDFPDIYFLPTKISTKTPNASNQTDSELYAFECPVYQTPERSRILATTGLP 4483
Query: 4462 -TFITVVYLRTVLSPDHWILRGVALLCD 4488
F+T VYL T P HWI VALLC+
Sbjct: 4484 TNFLTSVYLSTKKPPSHWITMRVALLCE 4511
Score = 578 bits (1491), Expect = e-164
Identities = 383/1287 (29%), Positives = 621/1287 (48%), Gaps = 126/1287 (9%)
Query: 1092 KKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILN 1151
+KK ++ + L++L ++++ L+ I +++ + + Y++
Sbjct: 800 EKKNKNLLEVVESSLQQLECDPTEIEEFLEHFIFLNAISSKISKLEKEFLTMSQLYSVAK 859
Query: 1152 RFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINF 1211
++ +++E+ L F++L+S + + KF+ NL + DV N
Sbjct: 860 HHQIHISEEQIAIFQVLLLKFSQLKSSMKLSKINKDTAITKFRDNLEACISGLHVDVGNL 919
Query: 1212 AEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKT 1271
+ A +Q L K YS + F +H
Sbjct: 920 KAKIRTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSHYQDCFS---DSQSHMHSV 976
Query: 1272 RKE----------------LNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEF 1315
E L L +KL+ + + + +D+E + + +
Sbjct: 977 NVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSLQSIDVESVQRNVSKL 1036
Query: 1316 QNRCRKLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDV 1375
+ L KGL LK+ + +F + P++ + N +K RHW+ + E+ G V
Sbjct: 1037 MHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEALQEIIGK--SV 1094
Query: 1376 ESDSFC-LRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGK 1434
D C + N++ + +++++I D+ SA E +E L ++I+ W L +
Sbjct: 1095 PLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLILHHTE 1154
Query: 1435 GELLLKGTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVV 1494
+ +I +E+S ++L ++ + + P K + W L+ S +EEW+
Sbjct: 1155 IYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNC 1214
Query: 1495 QNLWVYLEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQL 1554
Q W+YLE VF +I +QLP E + F + W KIM + N + + ++
Sbjct: 1215 QRNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVL-EI 1273
Query: 1555 LPHLHEQLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDN 1614
L + + LE +KSL YLE KRL+FPRF+F+S+ LL+IL + + ++QPHL +N
Sbjct: 1274 LQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFEN 1333
Query: 1615 INEVTFHAKDYD--RIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRS 1672
I ++ +D + +IS EGE +VL + + VE WL+++ K S+ ++++
Sbjct: 1334 IKQLLIWKQDIGPPAVKMLISAEGEGLVLPKKIRVRSAVEQWLVNVEK----SMFDVLKK 1389
Query: 1673 AFYQISDSGFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFL-- 1730
Y + +L F S Q+++ +D ++ ++ K+ +V
Sbjct: 1390 ERYIYNI----ILLFQS-----------QIMFYNDCVKSFVSSYSREKLEKVHAGLMCHL 1434
Query: 1731 -DILNTLISQTTHDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFY 1789
++ + ++ T++ +K L+ ++VH RDI +L+ +I + DFEW + ++
Sbjct: 1435 EEVADLVVLDTSNSRTK---AILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRHLQYK 1491
Query: 1790 FKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAG 1849
+ E VS + F Y E+LGCT RLVITPLTDRC++TL +AL +N+GG PAGPAG
Sbjct: 1492 WNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAG 1551
Query: 1850 TGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLS 1909
TGKTET KD+ + LGK+ VVFNC + +D++ + + F GL QSG+W CFDEFN I+L VLS
Sbjct: 1552 TGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFGLVQSGAWSCFDEFNLIDLEVLS 1611
Query: 1910 VAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRT 1969
V A QI + A+ +F+ +G + +N +F+TMNP Y G ELP+NLK FR
Sbjct: 1612 VIASQILTIKAAKDNYSARFVL-EGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFRP 1670
Query: 1970 VAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLR 2029
VAMMVP Q+I + L S GF L+ K LY+L +QL++Q HY+FGLR++ VL
Sbjct: 1671 VAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLI 1730
Query: 2030 TLGSQKR---ARPEDSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYA 2086
G++KR E E IV+ +R+ +L K ED PLF ++I D+FP + +
Sbjct: 1731 MAGTKKREFKCLSEADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQL 1790
Query: 2087 ELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQT 2146
L+ + Q GL N K++Q Y V G+M +GP+G GKTTV IL KA T
Sbjct: 1791 ALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQVCVGVMLVGPTGGGKTTVRRILEKALT 1850
Query: 2147 -------------ECGRPHREMR-------MNPKAITAPQMFGRLDTATNDWTDGIFSTL 2186
+ E + +NPK +T +++G+LD T +WTDG+ S
Sbjct: 1851 LLPIADFLSVAERKSASKISERKGKVDICVLNPKCVTLSELYGQLDPNTMEWTDGLLSAT 1910
Query: 2187 WR-------------------------------------------------KTLKAKKGE 2197
R K +K +
Sbjct: 1911 IRSYVYFNTPKNTKKDIDLRLKSRISDLSNVFKLDSSDTTETDDNIFEEIEKVVKIPENH 1970
Query: 2198 NI---FLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPA 2254
N ++ILDGPVD W+ENLNSVLDD +TL LAN +RI + +++FEV N+ ASPA
Sbjct: 1971 NFDWQWIILDGPVDTFWVENLNSVLDDTRTLCLANSERIALTNKIRVIFEVDNLSQASPA 2030
Query: 2255 TVSRMGMVYISSSALSWRPILQAWLKK 2281
TVSR MVY+ L W P +++WL K
Sbjct: 2031 TVSRCAMVYMDPVDLGWEPYVKSWLLK 2057
Score = 119 bits (297), Expect = 9e-26
Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 9/284 (3%)
Query: 2445 IAKQHKAVLLTGEQGTAKTVMV--KAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYV 2502
I + HK + + T K + K LK D + + ++NFS+ + I +
Sbjct: 2390 IPETHKTATGSSDNPTKKPEVRTNKKLLKNNDHKGVVVSTINFSTNVTAAKTKEMILKKL 2449
Query: 2503 DKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTT 2562
+R T G P ++ +FIDD+NMPV + +G Q E++RQ++++ G+Y +K +
Sbjct: 2450 IRRTKDTLGAPKNNRILIFIDDMNMPVSDMYGAQPPLELIRQLLDLGGVYDTEK-NTWKN 2508
Query: 2563 IVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFK 2622
I D+ ++AA + NDI RL + F++ PS + IF G + +F
Sbjct: 2509 IQDLSIVAACVPVV---NDISPRLLKHFSMLVLPHPSQDILCTIFQA-HLGIYFSINNFT 2564
Query: 2623 PQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIP 2682
P++ + ++S ++ + MLPTP+K HY+FNLRD+ ++ G+L S
Sbjct: 2565 PEVQKSKDQIISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKE 2624
Query: 2683 TLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEE--NIGSD 2724
LF HE +RV DR I D+ F L+R +E IG D
Sbjct: 2625 MAALLFVHEATRVFHDRLIDFTDKSLFYRLLSRELENCFQIGID 2668
>gi|114155135 dynein, axonemal, heavy chain 9 isoform 1 [Homo sapiens]
Length = 798
Score = 444 bits (1143), Expect = e-124
Identities = 253/811 (31%), Positives = 436/811 (53%), Gaps = 29/811 (3%)
Query: 3695 ITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYE 3754
+ ++S ++ MYQ SL F +F +++ R+ ++R+ N+I+ +T+ V+ Y++RGL+E
Sbjct: 1 MNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFE 60
Query: 3755 NHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWILDMTWLNLVEL 3814
K ++ +T +I L V E L++ ++ P ++ W + L
Sbjct: 61 CDKLTYLAQLTFQILLMNREVNAVELDFLLRS----PVQTGTASPVEFLSHQAWGAVKVL 116
Query: 3815 SKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTV 3874
S + +F+ + I + K WK + + + PE+E +P + + +L ++R+ PDR
Sbjct: 117 SSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKT-ALQRLCMLRAMRPDRMT 175
Query: 3875 FQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKL--- 3931
+ R ++ + L KY L+ ++EES TP+ LS G DP +++ +KL
Sbjct: 176 YALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYT 235
Query: 3932 --KLECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFMEELLETLIT-TEASD 3988
+S+GQGQEV A + ++ ++G WV+LQN HL +++ L + L +E S
Sbjct: 236 FNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSH 295
Query: 3989 DSFRVWITTEPHDR-----FPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDI-SN 4042
FRV+++ EP P +L+ S+K TNEPP G+ A L + QD L++ S
Sbjct: 296 PEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSR 355
Query: 4043 LPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGV 4102
+K +L+ + + H+ V ERRKFGP GWN Y FN+ D + SV + N L E + K V
Sbjct: 356 ETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFL-EANAK--V 412
Query: 4103 SWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTGYKIPLCKTLDQ 4162
++ +RY+ GE+ YGG +TDD+D+RL + + +M E G+ +P +
Sbjct: 413 PYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNG 472
Query: 4163 YFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGG--GVGETREAI 4220
Y +YI + ++P ++GLHPNA+I + + T+ + T+ +QP++S G G TRE
Sbjct: 473 YHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEK 532
Query: 4221 VYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLK 4280
V L E++L ++ ++ + + K+ + QE RM + ++ SL +L+
Sbjct: 533 VKALLEEILERVTDEF---NIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELE 589
Query: 4281 LAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSST-LGFWFTELLERNAQFSTWIFE 4339
L ++G + M+ ++ + + +Y +P+ W R ++ S+ L WF +LL R + W +
Sbjct: 590 LGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGD 649
Query: 4340 -GRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGV 4398
P+ W+TGFFNPQ FLTA+ Q R ++ W LD + + ++ ++ +EE SPP EG
Sbjct: 650 FTMPSTVWLTGFFNPQSFLTAIMQSTARKNE-WPLDQMALQCDMTKKNREEFRSPPREGA 708
Query: 4399 YIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRR 4458
YI+GL+M+GA WD + G + E+ K L +PV+ I AI + +Y CP+YK +R
Sbjct: 709 YIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQR 768
Query: 4459 TDLTFITVVYLRTVLSPDHWILRGVALLCDI 4489
T++ L+T +P W+L GVALL I
Sbjct: 769 GP-TYVWTFNLKTKENPSKWVLAGVALLLQI 798
>gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]
Length = 4753
Score = 162 bits (410), Expect = 7e-39
Identities = 221/962 (22%), Positives = 379/962 (39%), Gaps = 155/962 (16%)
Query: 1451 MEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDI 1510
+++SL VL +L+ + K WV + ++E WL Q W++L V I
Sbjct: 1218 IQESLQVLSKILAIEKSGDLNKIALEWVAIMHGLGALLEVWLTFQQKWIFLNKVLHEMKI 1277
Query: 1511 AKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGD---------ETMGQLLPHLHEQ 1561
RF+ +D + +M+ + +P V++ V + + QLL +
Sbjct: 1278 QFPNADLNSRFKVMDDQYRTLMRISVADPMVLSLVVPSAERSPYFQGQQLQQLLQAGSVE 1337
Query: 1562 LEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQ-------PHLPAVS-- 1612
LE SL L FPR FF+SD L+ +L +S Q PH+ AVS
Sbjct: 1338 LEGIIMSLESVLYGVCAHFPRLFFLSDSELVALLAARLESCEAQLWVRRCFPHVHAVSFR 1397
Query: 1613 ------DNIN--EVTFHAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLK-MQM 1663
N + E + + + +AV+ GE++ L + + WL L K +++
Sbjct: 1398 SCPTGEKNTDDWESSPNTQTQVEALAVLGAGGEEVKLQGPLPLHPDLPKWLASLEKCLRL 1457
Query: 1664 SSLHNI-------------IRSAFYQI-SDSGFQLLPFLSH-------FPAQVGLLGIQM 1702
+ +H + + A Q+ + L ++ H FP Q L+ ++
Sbjct: 1458 ALVHMLQGCVAARLARGPSLGEALKQLPKQNKLYLQLYVQHWIDLVQAFPWQCVLVAEEV 1517
Query: 1703 LWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLI-----SQTTHDLSKFDRVKF-ETLI 1756
+W + EEAL + M + + L++L + SQ L + L+
Sbjct: 1518 VWRAEMEEAL--LEWGTLAMVSMHMRKLEVLVNFMRAQRASQGGQSLPSVRQTSLLSALL 1575
Query: 1757 TIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYF-------KEDLD--QTVVS------- 1800
+ V RDI L + + TDF W++Q +++ K L +T+ S
Sbjct: 1576 VMAVTHRDIAQLLEQHQVSDLTDFHWVRQLKYHLGSPHIIPKSPLQSLKTIASSEPSLSP 1635
Query: 1801 ------ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTE 1854
+ F+Y E+LG + + L +R + L AL G GP G GK
Sbjct: 1636 AACWIDVLGRSFLYNYEYLGPRLGPLPSLLPERPALVLLLALEEVACGTVLGPNGVGKRA 1695
Query: 1855 TTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQ 1914
+ + LG+ +V+ CS Q++ + L G Q G+W ++ +++ +LS Q+
Sbjct: 1696 IVNSLAQALGRQLVMLPCSPQIEAQCLSNYLNGALQGGAWLLLEKVHQLPPGLLSALGQR 1755
Query: 1915 ------IYIVLTARKERKKQFI-----------FSDGDCVDLNPEFGIFLTMNPGYAGRQ 1957
+Y L R I F + V + +G L + A
Sbjct: 1756 LGELHHLYAPLYQEASRNTSTIDPTQPQLLGSSFFEKHHVSVRLGYGCLLVLR---ALSS 1812
Query: 1958 ELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVLYKL----------C 2007
+P NL + R VA+ +PD + + + L G + +A + + L C
Sbjct: 1813 AVPANLHLLLRPVALALPDLRQVAELTLLGAGMRDAFQMATRLSKFFSLERELVSGPLPC 1872
Query: 2008 EEQLTKQVHYDFGLRNI--------LSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKL 2059
L KQ+ D +R + R+L + + A S L ++ GL NL
Sbjct: 1873 RLPLLKQILED-TIRTLNVTKEEPKCQKPRSLAAIEEAALLRSPLFSILNGLHLHNLR-- 1929
Query: 2060 VDEDEPLFLSLINDLFPG---LQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYE 2116
L+ LFP + + TY ++ V ++Q GL P L QL +
Sbjct: 1930 ---------GLLCALFPSASQVLAEPMTYKLMKPLVVEELQQVGLDPSPDILGSLEQLSQ 1980
Query: 2117 TSLVRHGLMTLGPSGSGKTTVITILMKAQ----------TECGRPHREMRMNPKAITAPQ 2166
G++ LGP+GSGKTT L K Q T+ +P + P ++ +
Sbjct: 1981 ALSRASGILLLGPAGSGKTTCWHSLFKIQNRLAAMEDTSTQGCQPVEITHLYPSGLSPQE 2040
Query: 2167 MFGRLDTATNDWTDGIFSTLWRKT-------LKAKKGENI----FLILDGPVDAIWIENL 2215
G L+ + W GIF + R K + E+I ++I DG + W++++
Sbjct: 2041 FLGWLEGSC--WHHGIFPKVLRAAGQCNNMGQKRQTEESIGIQHWIICDGASNGAWLDSI 2098
Query: 2216 NSVLDDNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPIL 2275
+L + L+L +G +I P LL EV + SP V +V+ +W+ IL
Sbjct: 2099 TCLLSELPQLSLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCALVWCGGEQ-TWQCIL 2157
Query: 2276 QA 2277
A
Sbjct: 2158 SA 2159
Score = 83.6 bits (205), Expect = 4e-15
Identities = 167/806 (20%), Positives = 303/806 (37%), Gaps = 127/806 (15%)
Query: 2748 DEPEDSVF----------EVPKIYELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKD 2797
++P D VF E P +Y L ++ L E+L Q S L
Sbjct: 2814 EKPSDLVFSQELILGPNSETPNLY-LERQWEKLEEQLATSAAQLK-----LSPHLARCHS 2867
Query: 2798 AMTHLIKISRII-RTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLT 2856
H+ ++ R++ R LL G G+G+ + LAS I F + S + +
Sbjct: 2868 MAQHVARLVRVLARPRQHGLLLSGALGTGRHTAITLASSICQAHFFHLP---SGSEEAIL 2924
Query: 2857 DDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQ-- 2914
L+ AG + + + D L L L +SG + ++D I +
Sbjct: 2925 QCLRDASWHAGMLSQPVALLVPSGV--DLTTLHRLLALATSGSFPGQYTEADLDRIGEHL 2982
Query: 2915 -----GLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARSLK---F 2966
G+ +K+E+ + + F + +LH+ F +G+K + L F
Sbjct: 2983 PRENLGVKQNIKKEM---------VLQRFHQQVCSHLHL---FFLIGDKQAHKQLPSTLF 3030
Query: 2967 PGLISGCT--MDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSESC 3024
L+ T +D + W + AL VA + L V + + + +
Sbjct: 3031 LRLLQLATASIDRYEPWDQAALAKVAQHHLEGAQSVPLDDGSWKYPDLQASIPSVAKAMA 3090
Query: 3025 ESYFQRYRRRAH-------VTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKL--- 3074
+ H VTPK++L F++ + + + + I +A+R+ L+ L
Sbjct: 3091 LIHLSATHYHEHLCPALPLVTPKTFLDFLDTFLMLQQQTILKIKNKAQRVQNALENLRML 3150
Query: 3075 MEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKA---Q 3131
++ + A L DL + K+ + + L Q+ K +++E + + +
Sbjct: 3151 IKEHGTHANLIFDLEQQLKDSGKSLSMFQQQLE------QSKLLYKQQLEECRHQENLIE 3204
Query: 3132 KIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVL 3191
+ + D+ + + E+ LE A E L+ ++ D +R PP ++R+ D +
Sbjct: 3205 NLARQRDALQAQREAFLEQMSKAFLEP---LSQLQVADFEEIRSYRAPPESVVRVTDAMC 3261
Query: 3192 LLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINEETVELLQPYFN 3251
LF + W + +L+ F L FPK+ I + + L
Sbjct: 3262 DLFHHET--------------GWASAKQLLCTEDFYQELVFFPKEKITDSELIKLHLILK 3307
Query: 3252 MDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINR-EVLPLKANLAKQEGRLAVANAELG- 3309
+ + V A L +W A+ + YG+ LP L + E L A LG
Sbjct: 3308 APGMDDAALRAVSRPAASLAAWLWAV-LHYGLAHCRGLPTDLLLQQVEATLTREQARLGY 3366
Query: 3310 ---KAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCR-KKMQAASTLIDGLSGEKI 3365
+AQ L+ A L K+ A+ N L+ A + K + L+ +
Sbjct: 3367 YQFQAQETLEHNLA-LAKMVEDAQASHNCVAKTLSQAQCGQYHKWPMKAALLTPMRA--- 3422
Query: 3366 RWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQW-------------- 3411
WT Q ++ K + + GD LLC+ + YLGPF + R LL D+W
Sbjct: 3423 -WTTQLQKLKGRCMTVFGDTLLCSAAIIYLGPFPPLRRQELL-DEWLALCRGFQEALGPD 3480
Query: 3412 ------EMELRARKIPFTENL-------NLISMLVDPPTIGEWGLQGLPGDDLSIQNGII 3458
+ + ++ IP L +++S+L +W P + G++
Sbjct: 3481 DVAQALKRKQKSVSIPPKNPLLATHSPFSILSLLSSESEQYQWDGNLKPQAKSAHLAGLL 3540
Query: 3459 VTKAT-----RYPLLIDPQTQGKTWI 3479
+ T R+PLL+DP + W+
Sbjct: 3541 LRSPTHYSSCRWPLLLDPSNEALIWL 3566
Score = 57.8 bits (138), Expect = 2e-07
Identities = 97/462 (20%), Positives = 178/462 (38%), Gaps = 52/462 (11%)
Query: 2342 CVEHLHKL--FVFGLMWSLGALLELESREKLEAFLRQHESKL-DLPEIPKGSNQTMYEFY 2398
C EHL + F+F L+W GA L + F+R S+L + PE P + +++ +
Sbjct: 2277 CREHLLAVSSFLFALIWGFGAHLPSRFWPIFDTFIRDSISRLSNYPEPPPSA--LVFDLH 2334
Query: 2399 VTDYGDWEHWNKKLQPY--YYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTG 2456
V+ + L P+ Y + I P++ R +++D + + VLL G
Sbjct: 2335 VSPE------DGTLVPFTGQYLSSHIKGTLGTFHPSIQTERLLYVVDLLLSGGQPVLLAG 2388
Query: 2457 EQGTAKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGR 2516
E T K+ V+ ++ + P + FSS+ ++ R I+ +
Sbjct: 2389 EAATGKSAFVEVLVEPHHPYIYSPIHPAFSSSHLRLLLSRGIQGQTQASPQPGHHQDSKP 2448
Query: 2517 KMTVFIDDINMPVIN-EWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHP 2575
+ ++D+++ + E Q E +RQ M+ +Y+ T V +A + P
Sbjct: 2449 SLLFLLEDLHLATSDPEKSCQPVLETLRQAMD-GTVYAHSTLELQTLQPTVNFLATVTVP 2507
Query: 2576 GGGRNDIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSV 2635
G + RL R FTV + A++ + I + + S + + + LV
Sbjct: 2508 GYCERPLCPRLFRLFTVLALESMTQATLLERHVPIIQAWLERFPSVERERA-LARGLVRA 2566
Query: 2636 GRVLWQWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAE------------------- 2676
W+ +P+P HY F+L +S + + +
Sbjct: 2567 SVEAWEAVCNCFMPSPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRGFVDYPNHQEHLRRV 2626
Query: 2677 -----ECASI----PTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGSDAAS 2727
C ++ ++ L+ HE R DR +P E+ + A L V +++
Sbjct: 2627 SGLRGTCLTVMMATRNVVRLWLHEAQRTFCDRLDSPR-ERSYCAKLLLVVAQSV-----F 2680
Query: 2728 CILPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDF 2769
C P P + ++ E +E E+ V EV EL DF
Sbjct: 2681 CCGPGPQHLG--KDHQESEEEEEEERVPEVESEGELAQWEDF 2720
Score = 48.9 bits (115), Expect = 1e-04
Identities = 184/1013 (18%), Positives = 337/1013 (33%), Gaps = 136/1013 (13%)
Query: 3555 FKLYITTKLPNPAFTPEINAKT----SVIDFTVTMKGLENQLLRRVILTEKQELEAERVK 3610
F LY++T L A + + +V+D + M+ LE Q+L ++ E ELE
Sbjct: 3720 FCLYLSTTLSLCAMEKVLGCELLKGLNVLDLGLNMEILEEQMLHEILCREYPELETRWQD 3779
Query: 3611 LLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAET 3670
L + ++ E+ LL L + + + ++
Sbjct: 3780 LKIRALDTCKAVEAAEERLLTMLLFQNPKRQKPAKFLRNIVRAQGKLCQLRAHCEELEGQ 3839
Query: 3671 EIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQ 3730
+++ +RP G + ++++ + ++ S +L + Q++ + +
Sbjct: 3840 KLQEMVLWAPYRPVVWHGMAMVKALSQLQNLLPLFCMSPENWLAVTKQALDSMKPREINH 3899
Query: 3731 -----KRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIK 3785
+ + +LT ++ +V L L L L + G E AL
Sbjct: 3900 GEDLASHLLQLRAHLTRQLLGSTVTALGLTQVPLVGALGALALLQATGKASELERLALWP 3959
Query: 3786 GGAALDLKACPPKPY------RWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFD 3839
G AA KP W+ W L LP F + ++ + W+++
Sbjct: 3960 GLAA-SPSTVHSKPVSDVARPAWLGPKAWHECEMLELLPPFVGLCASLAGHSSAWQAYLS 4018
Query: 3840 KDAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKY----IADSLEEKYTEPVIL 3895
+ P + L KL+L R P+ + + L+E P +
Sbjct: 4019 LSSTVLGPAPGPGPEPLSLLQKLILWRVLRPECLAGALADFTTSLLGRPLDENTYAPTM- 4077
Query: 3896 NLEKTWEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQ-EVHAR----- 3949
++ S P++ L P+ + L KL + GQ Q +V A
Sbjct: 4078 ----PFKHSQATQPMLILLPPPGHPSATLHPLTVIQKLAAK-YQQGQKQLQVIALGSEAW 4132
Query: 3950 -------KLIQMSMQQGGWVLLQNCHLGLEFMEELLETLI-------------------- 3982
+ +M +G W++L NCHL + +ELL+ L+
Sbjct: 4133 DPVSVVVSTLSQAMYEGHWLVLDNCHLMPHWPKELLQLLLELLGRAKVVADLESEQLLDQ 4192
Query: 3983 ----TTEASDDSFRVW--ITTEPHDRFPITLLQTSLK-FTNEPPQGVRAG-LKRTFAGIN 4034
FR+W + E P L Q S+ F N Q + G + +
Sbjct: 4193 PESRNVSTVHRDFRLWLIVPAESSASLPAVLTQHSMPVFWN---QSLELGHVLIDSVELA 4249
Query: 4035 QDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLD 4094
Q +L + P+L LH + R+ +G + Q +Q D
Sbjct: 4250 QQVLYMQPPTQALPLL----LLHGLLLHRQLYGT---RLQAHRGRWSQVTLTQVLQTQ-D 4301
Query: 4095 ECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSE------KMFEPSFCF 4148
+ ++ + V YGG + D D+ L + S + P
Sbjct: 4302 QLWASLSNPRAAMQELAASVFYGGPLGDTEDREALISLTQACLSPSSGSWVQPHTPQSLL 4361
Query: 4149 YTGYKIPLCKTLDQYFE---YIQSLPSLDNPEVFGLHPNAD---ITYQSNTASAVLETIT 4202
T +P + LD E + LPS P + GL + QS + L+ +
Sbjct: 4362 ATLMPLPELRELDAMAECKAQMHLLPSPPEPRLCGLSEGPQAWLLRRQSRALLSALQRSS 4421
Query: 4203 NIQPKESGGGVGETREAIVYRLSE-DMLSKLPPDYIPHEVKS-------RLIKMGHLNSM 4254
+ ES G + RL + + + D + H ++ ++ +
Sbjct: 4422 PVWVPESRRGAQLAERRLRQRLVQVNRRLESLQDLLTHVIRQDESDAPWSVLGPNARRPL 4481
Query: 4255 NIFLRQEIDRMQRVISILRSSLSDLKLAIEGT-IIMSENLRDALDNMYDARIPQLWK-RV 4312
L E + +++ L+ L L ++G S ++ R+P W+
Sbjct: 4482 EGVLETEALELSQLVGTLQRDLDCLLQQLKGAPPCPSRRCAAVAHALWTGRLPLPWRPHA 4541
Query: 4313 SWDSSTLGFWFTELLERNAQFSTWIFEGR-------PNVFWMTGFFNPQGFLTAMRQEVT 4365
W +L R ++ G VF ++ F +P+ L A+R E
Sbjct: 4542 PAGPQPPWHWLRQLSRRGQLLVRYLGVGADASSDVPERVFHLSAFRHPRRLLLALRGEAA 4601
Query: 4366 --------------------RAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGLYM 4405
+K +++ +H V + P G+ + GL +
Sbjct: 4602 LDQNVPSSNFPGSRGSVSSQLQYKRLEMNSNPLHFRVENGPNPTV---PERGLLLIGLQV 4658
Query: 4406 DGAAWDRRNGKLMESTPKVLFTQLPVLHIF-----AINSTAPKDPKLYVCPIY 4453
A WD G L +S P + LP + I + AP D +Y CP+Y
Sbjct: 4659 LHAEWDPIAGALQDS-PSSQPSPLPPVSISTQAPGTSDLPAPADLTVYSCPVY 4710
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 48.9 bits (115), Expect = 1e-04
Identities = 139/653 (21%), Positives = 256/653 (39%), Gaps = 127/653 (19%)
Query: 610 RETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKM 669
+ K +I +K ++ E K+L +L+ K D+ + L L + + + +V + T +
Sbjct: 795 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE- 853
Query: 670 KKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEM---HIDTVLKEI 726
+V+ L L L ++ F+++ NQ KI D E+ +++ +I
Sbjct: 854 -EVKMTLNDTLAKTNRELLDVKKKFEDI-------NQEFVKIKDKNEILKRNLENTQNQI 905
Query: 727 AKTVLISLPESGATKVEDMLTLNETYTKEW---ADILNHKSKHVEEAV----------RE 773
K ISL E A M +L+++ K A+IL + K EE V +E
Sbjct: 906 -KAEYISLAEHEAK----MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 960
Query: 774 LISIFEQIYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKK 833
L +I E I +VKY V + +RK E + + + V+E + + E K
Sbjct: 961 LDTIQECI-KVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1019
Query: 834 ECKEVFAFFSHQLLDSLQKATRL--SLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAI 891
KE+F L L+ T L M+R + + KQ +D+ S+ + +
Sbjct: 1020 LKKEIFT-----LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----SQKYTEV 1069
Query: 892 PNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGK 951
NV ++ + + T E+ V + Q+Q P++ V + + T +N +
Sbjct: 1070 KNVK--------EKLVEENAKQTSEI-LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1120
Query: 952 LLKKEERSFE-EAIPARKL-------KNFYPGVAEH------------------------ 979
LK +R +E E KL KN +AEH
Sbjct: 1121 ELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEE 1180
Query: 980 -----KDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWT--EDRDVKVKEFLAN-NPS 1031
+++SKL + ++ +L+K + D KYK + E + + E LAN N
Sbjct: 1181 SQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1240
Query: 1032 LTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLN--E 1089
E+ E+LH E + K E + ++ E K K + L
Sbjct: 1241 YEEVCEEVLHAKKKEISAKDEK------------ELLHFSIEQEIKDQKERCDKSLTTIT 1288
Query: 1090 EYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAI 1149
E ++++ I K++ + D++ ++ A+ LS Q+ T G
Sbjct: 1289 ELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS-------QLTYTSG-------- 1333
Query: 1150 LNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVE 1202
TK +S+ +DTL++ L+ + +V ++++LL + +
Sbjct: 1334 ------NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQ 1380
Score = 40.4 bits (93), Expect = 0.040
Identities = 119/547 (21%), Positives = 218/547 (39%), Gaps = 97/547 (17%)
Query: 926 QQQIRPIKSVIPSPTTTDVTHQNTGKLLKKE---ERSFEEAIPARKLK---NFYPGVAEH 979
+ +RP++ +PS T+ + ++LKKE R+F E+ +LK VAE
Sbjct: 407 RSMLRPLELSLPSQTS-----YSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAEC 461
Query: 980 KDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKE--FLANNPSLTEIRS 1037
K ++ + + K +AL+D QK ++ + VK + FLA LT +
Sbjct: 462 KALALECERVKEDSDEQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTSEAA 519
Query: 1038 EILHYATFEQEIDELKPIIV--------VGAL------------ELHTEPMKLALSIEAK 1077
H T E + D+LK + V VG L E + KL +
Sbjct: 520 SGNHRLTEELK-DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 578
Query: 1078 AWKMLLCRYLNEEYKKKMSYMIAFINEYLKKL--SRPIRDLDDVRFAM-----EALSCIR 1130
++ +C E+ +K++ M E KL S P ++++ ++ E +
Sbjct: 579 QKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLV 638
Query: 1131 DNEIQMDMTLGPIEEAYAILNRFEVEVTK----EESEAVDTLRYSFNKLQSKAVSVQEDL 1186
+ E + + +L I + L + ++ + EE E V + +L+ K+ + + +
Sbjct: 639 EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKS------RLEQKSGELGKKI 692
Query: 1187 VQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQ-IFQASFDDLW 1245
++ K ++ E +V+ ++ + +A+ L M + P + S ++ A DDL
Sbjct: 693 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 752
Query: 1246 RKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDI 1305
RK L VT K E LL+ D++ +S + V
Sbjct: 753 RKL-----------LDVTQKYTEKKLEMEKLLLEN-----DSLSKDVSRLETVF---VPP 793
Query: 1306 EKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDD--------FSESCPLLEMMTNKAM 1357
EK E++ ++ +L K L + LKK+ + SE+ L +MM+N+ +
Sbjct: 794 EKHEKEIIALKSNIVELKKQLSE------LKKKCGEDQEKIHALTSENTNLKKMMSNQYV 847
Query: 1358 KQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQV 1417
+ + + +D+ N LL K EDI +K KD L +
Sbjct: 848 PVKTHEEVKMTL-------NDTLAKTN---RELLDVKKKFEDINQEFVKIKDKNEILKRN 897
Query: 1418 IENWTNQ 1424
+EN NQ
Sbjct: 898 LENTQNQ 904
Score = 33.1 bits (74), Expect = 6.4
Identities = 148/777 (19%), Positives = 305/777 (39%), Gaps = 148/777 (19%)
Query: 708 LKKISDLCEMHIDTVLKEIAKTVLISLPESGATKVEDM----LTLNETYTKEWADILNHK 763
+K+ SD ++ LK++ K + S KV+ M L L E T E A +
Sbjct: 471 VKEDSDEQIKQLEDALKDVQKRMYES-----EGKVKQMQTHFLALKEHLTSEAASGNHRL 525
Query: 764 SKHVEEAVRELISIFEQIYEVKYTG---KVGK---QSEQRKHVVFGSETGEGENNDYEAN 817
++ +++ +++L +VKY G +VGK Q +Q + +V + EG+ +
Sbjct: 526 TEELKDQLKDL--------KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKR 577
Query: 818 IVNEFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSE 877
+ E + E E K +K T + + +A ++ E
Sbjct: 578 LQKELSMCEMEREKKG-----------------RKVTEMEGQAKELSAKLALSIPAEKFE 620
Query: 878 DIISFIKSEVHLAIPNVVMIP-----SLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPI 932
++ S + +EV+ +V + SL +I+Q + + ++++ V +Q++
Sbjct: 621 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR 680
Query: 933 ---KSVIPSPTTTDVTHQNT------------GKLLKKEERSFEEAIPARKLKNFYPGVA 977
KS T++T +N KLLK++ + ++KN Y +
Sbjct: 681 LEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL-----TIEMKNHYVPLK 735
Query: 978 EHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTE--- 1034
+D+ K + +N + L QKY ++ +++++ L N SL++
Sbjct: 736 VSEDMKKSHDAIIDDLN------RKLLDVTQKYT-----EKKLEMEKLLLENDSLSKDVS 784
Query: 1035 -IRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKK 1093
+ + + E+EI LK IV EL + +L K+ N KK
Sbjct: 785 RLETVFVPPEKHEKEIIALKSNIV----ELKKQLSELKKKCGEDQEKIHALTSENTNLKK 840
Query: 1094 KMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRF 1153
MS N+Y+ P++ ++V+ + D + + L +++ + +N+
Sbjct: 841 MMS------NQYV-----PVKTHEEVKMTLN------DTLAKTNRELLDVKKKFEDINQE 883
Query: 1154 EVEVTKEESEAVDTLRYSFNKLQSKAVSVQE------DLVQVQPKFKSNLLESVEVFR-- 1205
V++ + L + N+++++ +S+ E L Q K + + E + +R
Sbjct: 884 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 943
Query: 1206 -EDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSS------GEQLF 1258
E+++ + + + I QE SF++ RKF EQ
Sbjct: 944 QEEIVTLHAEIKAQKKELDTI--QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1001
Query: 1259 GLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNR 1318
V++ EV ++ L ++++ L + V IEK + +
Sbjct: 1002 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT----------VLIEKSHEMERALSRK 1051
Query: 1319 CRKLPKGLKDW-QAFLDLK----KRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPF 1373
+L K LKD Q + ++K K +++ ++ + + N KQ P
Sbjct: 1052 TDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQH----------VPL 1101
Query: 1374 D-VESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFA 1429
+ VE+ L+ + + K++++ + KE+ KL Q++EN N ++ A
Sbjct: 1102 EQVEA----LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLA 1154
Score = 33.1 bits (74), Expect = 6.4
Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 10/128 (7%)
Query: 3046 INGYKNIYAEKVKFINEQAERMNIGLDKLMEASE----SVAKLSQDLAVKE---KELAVA 3098
+NG E++K + E+ + KL + E S L++ L +KE KE+ +
Sbjct: 1111 LNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGII 1170
Query: 3099 SIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIV--DEIDSEKVKA-ESKLEAAKPAL 3155
E E + +K+++EVQ K +K+ + +D K KA +S LE +L
Sbjct: 1171 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSL 1230
Query: 3156 EEAEAALN 3163
E A LN
Sbjct: 1231 NEKLANLN 1238
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 48.9 bits (115), Expect = 1e-04
Identities = 139/653 (21%), Positives = 256/653 (39%), Gaps = 127/653 (19%)
Query: 610 RETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKM 669
+ K +I +K ++ E K+L +L+ K D+ + L L + + + +V + T +
Sbjct: 808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE- 866
Query: 670 KKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEM---HIDTVLKEI 726
+V+ L L L ++ F+++ NQ KI D E+ +++ +I
Sbjct: 867 -EVKMTLNDTLAKTNRELLDVKKKFEDI-------NQEFVKIKDKNEILKRNLENTQNQI 918
Query: 727 AKTVLISLPESGATKVEDMLTLNETYTKEW---ADILNHKSKHVEEAV----------RE 773
K ISL E A M +L+++ K A+IL + K EE V +E
Sbjct: 919 -KAEYISLAEHEAK----MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 973
Query: 774 LISIFEQIYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKK 833
L +I E I +VKY V + +RK E + + + V+E + + E K
Sbjct: 974 LDTIQECI-KVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1032
Query: 834 ECKEVFAFFSHQLLDSLQKATRL--SLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAI 891
KE+F L L+ T L M+R + + KQ +D+ S+ + +
Sbjct: 1033 LKKEIFT-----LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----SQKYTEV 1082
Query: 892 PNVVMIPSLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGK 951
NV ++ + + T E+ V + Q+Q P++ V + + T +N +
Sbjct: 1083 KNVK--------EKLVEENAKQTSEI-LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1133
Query: 952 LLKKEERSFE-EAIPARKL-------KNFYPGVAEH------------------------ 979
LK +R +E E KL KN +AEH
Sbjct: 1134 ELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEE 1193
Query: 980 -----KDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWT--EDRDVKVKEFLAN-NPS 1031
+++SKL + ++ +L+K + D KYK + E + + E LAN N
Sbjct: 1194 SQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1253
Query: 1032 LTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLN--E 1089
E+ E+LH E + K E + ++ E K K + L
Sbjct: 1254 YEEVCEEVLHAKKKEISAKDEK------------ELLHFSIEQEIKDQKERCDKSLTTIT 1301
Query: 1090 EYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAI 1149
E ++++ I K++ + D++ ++ A+ LS Q+ T G
Sbjct: 1302 ELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS-------QLTYTSG-------- 1346
Query: 1150 LNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVE 1202
TK +S+ +DTL++ L+ + +V ++++LL + +
Sbjct: 1347 ------NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQ 1393
Score = 40.4 bits (93), Expect = 0.040
Identities = 119/547 (21%), Positives = 218/547 (39%), Gaps = 97/547 (17%)
Query: 926 QQQIRPIKSVIPSPTTTDVTHQNTGKLLKKE---ERSFEEAIPARKLK---NFYPGVAEH 979
+ +RP++ +PS T+ + ++LKKE R+F E+ +LK VAE
Sbjct: 420 RSMLRPLELSLPSQTS-----YSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAEC 474
Query: 980 KDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKE--FLANNPSLTEIRS 1037
K ++ + + K +AL+D QK ++ + VK + FLA LT +
Sbjct: 475 KALALECERVKEDSDEQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTSEAA 532
Query: 1038 EILHYATFEQEIDELKPIIV--------VGAL------------ELHTEPMKLALSIEAK 1077
H T E + D+LK + V VG L E + KL +
Sbjct: 533 SGNHRLTEELK-DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 591
Query: 1078 AWKMLLCRYLNEEYKKKMSYMIAFINEYLKKL--SRPIRDLDDVRFAM-----EALSCIR 1130
++ +C E+ +K++ M E KL S P ++++ ++ E +
Sbjct: 592 QKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLV 651
Query: 1131 DNEIQMDMTLGPIEEAYAILNRFEVEVTK----EESEAVDTLRYSFNKLQSKAVSVQEDL 1186
+ E + + +L I + L + ++ + EE E V + +L+ K+ + + +
Sbjct: 652 EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKS------RLEQKSGELGKKI 705
Query: 1187 VQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQ-IFQASFDDLW 1245
++ K ++ E +V+ ++ + +A+ L M + P + S ++ A DDL
Sbjct: 706 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 765
Query: 1246 RKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDI 1305
RK L VT K E LL+ D++ +S + V
Sbjct: 766 RKL-----------LDVTQKYTEKKLEMEKLLLEN-----DSLSKDVSRLETVF---VPP 806
Query: 1306 EKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDD--------FSESCPLLEMMTNKAM 1357
EK E++ ++ +L K L + LKK+ + SE+ L +MM+N+ +
Sbjct: 807 EKHEKEIIALKSNIVELKKQLSE------LKKKCGEDQEKIHALTSENTNLKKMMSNQYV 860
Query: 1358 KQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQV 1417
+ + + +D+ N LL K EDI +K KD L +
Sbjct: 861 PVKTHEEVKMTL-------NDTLAKTN---RELLDVKKKFEDINQEFVKIKDKNEILKRN 910
Query: 1418 IENWTNQ 1424
+EN NQ
Sbjct: 911 LENTQNQ 917
Score = 33.1 bits (74), Expect = 6.4
Identities = 148/777 (19%), Positives = 305/777 (39%), Gaps = 148/777 (19%)
Query: 708 LKKISDLCEMHIDTVLKEIAKTVLISLPESGATKVEDM----LTLNETYTKEWADILNHK 763
+K+ SD ++ LK++ K + S KV+ M L L E T E A +
Sbjct: 484 VKEDSDEQIKQLEDALKDVQKRMYES-----EGKVKQMQTHFLALKEHLTSEAASGNHRL 538
Query: 764 SKHVEEAVRELISIFEQIYEVKYTG---KVGK---QSEQRKHVVFGSETGEGENNDYEAN 817
++ +++ +++L +VKY G +VGK Q +Q + +V + EG+ +
Sbjct: 539 TEELKDQLKDL--------KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKR 590
Query: 818 IVNEFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSE 877
+ E + E E K +K T + + +A ++ E
Sbjct: 591 LQKELSMCEMEREKKG-----------------RKVTEMEGQAKELSAKLALSIPAEKFE 633
Query: 878 DIISFIKSEVHLAIPNVVMIP-----SLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPI 932
++ S + +EV+ +V + SL +I+Q + + ++++ V +Q++
Sbjct: 634 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR 693
Query: 933 ---KSVIPSPTTTDVTHQNT------------GKLLKKEERSFEEAIPARKLKNFYPGVA 977
KS T++T +N KLLK++ + ++KN Y +
Sbjct: 694 LEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL-----TIEMKNHYVPLK 748
Query: 978 EHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTE--- 1034
+D+ K + +N + L QKY ++ +++++ L N SL++
Sbjct: 749 VSEDMKKSHDAIIDDLN------RKLLDVTQKYT-----EKKLEMEKLLLENDSLSKDVS 797
Query: 1035 -IRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKK 1093
+ + + E+EI LK IV EL + +L K+ N KK
Sbjct: 798 RLETVFVPPEKHEKEIIALKSNIV----ELKKQLSELKKKCGEDQEKIHALTSENTNLKK 853
Query: 1094 KMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRF 1153
MS N+Y+ P++ ++V+ + D + + L +++ + +N+
Sbjct: 854 MMS------NQYV-----PVKTHEEVKMTLN------DTLAKTNRELLDVKKKFEDINQE 896
Query: 1154 EVEVTKEESEAVDTLRYSFNKLQSKAVSVQE------DLVQVQPKFKSNLLESVEVFR-- 1205
V++ + L + N+++++ +S+ E L Q K + + E + +R
Sbjct: 897 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 956
Query: 1206 -EDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSS------GEQLF 1258
E+++ + + + I QE SF++ RKF EQ
Sbjct: 957 QEEIVTLHAEIKAQKKELDTI--QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1014
Query: 1259 GLPVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNR 1318
V++ EV ++ L ++++ L + V IEK + +
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT----------VLIEKSHEMERALSRK 1064
Query: 1319 CRKLPKGLKDW-QAFLDLK----KRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPF 1373
+L K LKD Q + ++K K +++ ++ + + N KQ P
Sbjct: 1065 TDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQH----------VPL 1114
Query: 1374 D-VESDSFCLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFA 1429
+ VE+ L+ + + K++++ + KE+ KL Q++EN N ++ A
Sbjct: 1115 EQVEA----LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLA 1167
Score = 33.1 bits (74), Expect = 6.4
Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 10/128 (7%)
Query: 3046 INGYKNIYAEKVKFINEQAERMNIGLDKLMEASE----SVAKLSQDLAVKE---KELAVA 3098
+NG E++K + E+ + KL + E S L++ L +KE KE+ +
Sbjct: 1124 LNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGII 1183
Query: 3099 SIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIV--DEIDSEKVKA-ESKLEAAKPAL 3155
E E + +K+++EVQ K +K+ + +D K KA +S LE +L
Sbjct: 1184 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSL 1243
Query: 3156 EEAEAALN 3163
E A LN
Sbjct: 1244 NEKLANLN 1251
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 43.9 bits (102), Expect = 0.004
Identities = 100/440 (22%), Positives = 184/440 (41%), Gaps = 71/440 (16%)
Query: 799 HVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSL 858
H + G ++ E +YE ++D E +C+E+ A +++S + AT L L
Sbjct: 28 HELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEI---VVNSAKVATALKL 84
Query: 859 D--------TMKRRI-----FVASLYGRKQ-SEDIISFIKSEVHLAIPNVVMIPSLDDIQ 904
++K+ I V S Y ++Q +++ I +K E+ + + +V S +
Sbjct: 85 SQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI-VNLTKLVEQGSGLSMD 143
Query: 905 QAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSFEEAI 964
Q N I+ L V Q + + + S T Q T ERS EEA
Sbjct: 144 QHSN--IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQET-------ERSKEEA- 193
Query: 965 PARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTE------DR 1018
EH +S +++ +EA ++F+K + L E D
Sbjct: 194 -------------EHA--------ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
Query: 1019 DVKVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKA 1078
D + E A + + + E+ EQ++ E K + A EL M+ A +
Sbjct: 233 DSRQTEIKALQQYVQKSKEEL---QKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENE 289
Query: 1079 WKMLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAM-EALSCIRDNEIQMD 1137
L+C L++E ++K + A E + ++ I L+ +R + + L D + +++
Sbjct: 290 QHSLVCEQLSQENQQKALELKA-KEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVE 348
Query: 1138 MTLGPIEEAYAILNRFEVEVTKEESE----AVDTL---RYSFNKLQSKAVSV---QEDLV 1187
++ L R EVE +K+++E A+D L R NK KAV+ Q DLV
Sbjct: 349 QHKETLKNQIVGLER-EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
Query: 1188 QVQPKFKSNLLESVEVFRED 1207
++ + K NL ++ ++++
Sbjct: 408 KLHEQAKRNLEGEIQNYKDE 427
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 43.5 bits (101), Expect = 0.005
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 3077 ASESVAKLSQDLAVKEKELAVASIKADEVLAE-------VTVSAQASAKIKNEVQEVKDK 3129
A + +L +D+A KEK L V+ + D VL E + + +A+AK + +V + +
Sbjct: 32 AEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRR 91
Query: 3130 AQKIVDEIDSEKVK---AESKLEAAKPALEEAEAALNTIK 3166
Q + +E+D + + A KLE A+ A +E+E + I+
Sbjct: 92 IQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 131
>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
Length = 284
Score = 43.5 bits (101), Expect = 0.005
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 3077 ASESVAKLSQDLAVKEKELAVASIKADEVLAE-------VTVSAQASAKIKNEVQEVKDK 3129
A + +L +D+A KEK L V+ + D VL E + + +A+AK + +V + +
Sbjct: 32 AEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRR 91
Query: 3130 AQKIVDEIDSEKVK---AESKLEAAKPALEEAEAALNTIK 3166
Q + +E+D + + A KLE A+ A +E+E + I+
Sbjct: 92 IQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 131
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 40.8 bits (94), Expect = 0.031
Identities = 31/158 (19%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 3055 EKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIK-----------AD 3103
+ V+ +N+ E + + K+ E + + L Q A K ++L+ + D
Sbjct: 1086 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
Query: 3104 EVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALN 3163
EV + + + S + N++ E+K + K + + D EK + + L E +A L
Sbjct: 1146 EVTSHQKLEEERSV-LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
Query: 3164 TIKPNDIATVR---KLAKPPHLIMRIMDCVLLLFQKKI 3198
++ N++ +R AK H +++ ++ + + K+
Sbjct: 1205 KLR-NEVTVLRGENASAKSLHSVVQTLESDKVKLELKV 1241
Score = 36.2 bits (82), Expect = 0.75
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 8/146 (5%)
Query: 3024 CESYFQRYRRRAHVTPKSYLSFINGYKNIYAE---KVKFINEQAERMNIGLDKLMEASES 3080
C+ RY R T + + + + K+K E+ + L++L + ++
Sbjct: 976 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1035
Query: 3081 VAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSE 3140
AK +Q + + + + E LA + + Q +AK++NE+ +K+ K V+E++
Sbjct: 1036 -AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-- 1092
Query: 3141 KVKAESKLEAAKPALEEAEAALNTIK 3166
K++ L +EE + T+K
Sbjct: 1093 --KSKELLTVENQKMEEFRKEIETLK 1116
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 40.8 bits (94), Expect = 0.031
Identities = 31/158 (19%), Positives = 70/158 (44%), Gaps = 16/158 (10%)
Query: 3055 EKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIK-----------AD 3103
+ V+ +N+ E + + K+ E + + L Q A K ++L+ + D
Sbjct: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
Query: 3104 EVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALN 3163
EV + + + S + N++ E+K + K + + D EK + + L E +A L
Sbjct: 1181 EVTSHQKLEEERSV-LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
Query: 3164 TIKPNDIATVR---KLAKPPHLIMRIMDCVLLLFQKKI 3198
++ N++ +R AK H +++ ++ + + K+
Sbjct: 1240 KLR-NEVTVLRGENASAKSLHSVVQTLESDKVKLELKV 1276
Score = 36.2 bits (82), Expect = 0.75
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 8/146 (5%)
Query: 3024 CESYFQRYRRRAHVTPKSYLSFINGYKNIYAE---KVKFINEQAERMNIGLDKLMEASES 3080
C+ RY R T + + + + K+K E+ + L++L + ++
Sbjct: 1011 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1070
Query: 3081 VAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSE 3140
AK +Q + + + + E LA + + Q +AK++NE+ +K+ K V+E++
Sbjct: 1071 -AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-- 1127
Query: 3141 KVKAESKLEAAKPALEEAEAALNTIK 3166
K++ L +EE + T+K
Sbjct: 1128 --KSKELLTVENQKMEEFRKEIETLK 1151
Score = 32.7 bits (73), Expect = 8.3
Identities = 28/101 (27%), Positives = 53/101 (52%), Gaps = 3/101 (2%)
Query: 3286 EVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADT 3345
EV +++ + E LA+A G Q +L E +A++D+++ +AA EK++LLN +
Sbjct: 377 EVAKATSHVGEIEQELALARD--GHDQHVL-ELEAKMDQLRTMVEAADREKVELLNQLEE 433
Query: 3346 CRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVGDIL 3386
++K++ ++ S K Q+K A+I L +L
Sbjct: 434 EKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLL 474
>gi|83716024 kinesin family member 21B [Homo sapiens]
Length = 1624
Score = 40.8 bits (94), Expect = 0.031
Identities = 39/142 (27%), Positives = 68/142 (47%), Gaps = 10/142 (7%)
Query: 3043 LSFINGYKNIYAEKVKFINEQAER-MNIGLDKLMEASESVAKLSQDLAVKEKELAVASIK 3101
LS + Y A K+K E+ R MN L KL A + A+L ++ + E+EL K
Sbjct: 692 LSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELK----K 747
Query: 3102 ADEVLAEVTVSAQASAKIKNEVQE----VKDKAQKIVDEIDSEKVKAESKLEAAKPALEE 3157
+AE+ + A K E Q+ V+ K + + ++ E+ + E ++ A + +
Sbjct: 748 LQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQ 807
Query: 3158 AEAALNTIKPNDIATVRKLAKP 3179
E L K +++ +R+LAKP
Sbjct: 808 QEMVLRR-KTQEVSALRRLAKP 828
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 40.4 bits (93), Expect = 0.040
Identities = 36/134 (26%), Positives = 66/134 (49%), Gaps = 24/134 (17%)
Query: 3050 KNIYAEK--VKFINEQAER------------MNIGLDKLMEASESVAKLSQDLAVKEKEL 3095
KNI AE+ K E+A+R + + L KL + KL+++LA K KE+
Sbjct: 190 KNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEI 249
Query: 3096 AVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEK---VKAE------- 3145
+ D+V E+ + K+ E Q+++ + ++ E++ ++ +KA+
Sbjct: 250 EKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKI 309
Query: 3146 SKLEAAKPALEEAE 3159
KLEAAK +L+ A+
Sbjct: 310 KKLEAAKKSLQNAQ 323
Score = 38.5 bits (88), Expect = 0.15
Identities = 58/323 (17%), Positives = 129/323 (39%), Gaps = 31/323 (9%)
Query: 3054 AEKVKFINEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVAS----------IKAD 3103
A K K I + +RM+ D+L E + + K+ ++ EKE+ IKA
Sbjct: 243 ASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAK 302
Query: 3104 EVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALN 3163
E + +A+ K Q+ K + +DE++ E + E + + +EE +
Sbjct: 303 ENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS-- 360
Query: 3164 TIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSA 3223
+ D+ K H + ++++ D + + E K+ +
Sbjct: 361 --QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETE 418
Query: 3224 TGFLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGI 3283
L++ + N++ +E L+ Y + E KK+ G + + +A I
Sbjct: 419 AKIKQKLREIEE---NQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVE--MAKRRIDEI 473
Query: 3284 NREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAE-LDKVQAKFDAAMNEKMDLLND 3342
N+E+ + L +A + + ++ +++AE ++ ++ + ++ + L++
Sbjct: 474 NKELNQVMEQL---------GDARIDRQESSRQQRKAEIMESIKRLYPGSVYGR--LIDL 522
Query: 3343 ADTCRKKMQAASTLIDGLSGEKI 3365
+KK Q A T + G + + I
Sbjct: 523 CQPTQKKYQIAVTKVLGKNMDAI 545
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 40.0 bits (92), Expect = 0.052
Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 1/110 (0%)
Query: 3061 NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK 3120
+E A + D L +A+ S + L V+E+EL I + V E TV Q + +
Sbjct: 1502 DENARLQRVQYD-LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 3121 NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDI 3170
N ++E++ + QK+ +E++ K A K EE E ++K I
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAI 1610
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 40.0 bits (92), Expect = 0.052
Identities = 79/366 (21%), Positives = 148/366 (40%), Gaps = 69/366 (18%)
Query: 1394 KDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMED 1453
+D I ++C S I+ Q+IE N N F +L K + +I+ + ED
Sbjct: 1936 RDSISELCPSG----SIKQVALQIIEKLKNVN--FTKVTSGENILDKLSSLNKILNINED 1989
Query: 1454 SLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQ 1513
+ + +++S+ + ++W + ST +++ ++++QN V ++ +
Sbjct: 1990 TETSVQNIISSNLERTVQLISEDWSLEKST-HNLLSLFMMLQNANVTGSSL----EALSS 2044
Query: 1514 LPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGY- 1572
++++ N ++ W K Q + D T + HL ++ KS+
Sbjct: 2045 FIEKSETPYNFEELWPKFQQ-----------IMKDLTQDFRIRHLLSEMNKGIKSINSMA 2093
Query: 1573 LEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDRIMAV- 1631
L+K L F F + D L+ L I+ L + + E + +DY R++
Sbjct: 2094 LQKITLQFAHFLEILDSPSLKTL------EIIEDFLLVTKNWLQE--YANEDYSRMIETL 2145
Query: 1632 -ISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSH 1690
I E D +++AK W SL NI R+ + ++ FL+H
Sbjct: 2146 FIPVTNESSTEDIALLAKAIATFW---------GSLKNISRAGNFDVA--------FLTH 2188
Query: 1691 FPAQVGLLG---IQMLWTH-----------DSEEALRNAKD-DRKIMQVTNQKFLDILNT 1735
Q L +Q+L+ + +S+EA N D D +IM N ILN
Sbjct: 2189 LLNQEQLTNFSVVQLLFENILINLINNLAGNSQEAAWNLNDTDLQIMNFINL----ILNH 2244
Query: 1736 LISQTT 1741
+ S+T+
Sbjct: 2245 MQSETS 2250
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 158,943,169
Number of Sequences: 37866
Number of extensions: 6932274
Number of successful extensions: 20131
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 18564
Number of HSP's gapped (non-prelim): 1316
length of query: 4490
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4367
effective length of database: 13,590,000
effective search space: 59347530000
effective search space used: 59347530000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.