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Search of human proteins with 42544177
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42544177 complement component (3d/Epstein Barr virus)
receptor 2 isoform 2 [Homo sapiens]
(1033 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 2210 0.0
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 2153 0.0
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 581 e-165
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 560 e-159
gi|148886654 polydom [Homo sapiens] 372 e-102
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 345 1e-94
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 345 1e-94
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 320 4e-87
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 315 2e-85
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 256 8e-68
gi|4502503 complement component 4 binding protein, alpha chain p... 251 2e-66
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 248 2e-65
gi|157419154 selectin P precursor [Homo sapiens] 216 7e-56
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 202 2e-51
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 165 2e-40
gi|187960042 selectin E precursor [Homo sapiens] 159 2e-38
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 139 1e-32
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 139 1e-32
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 139 1e-32
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 138 3e-32
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 138 3e-32
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 137 4e-32
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 2210 bits (5727), Expect = 0.0
Identities = 1033/1033 (100%), Positives = 1033/1033 (100%)
Query: 1 MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE 60
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE
Sbjct: 1 MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE 60
Query: 61 KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT 120
KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT
Sbjct: 61 KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT 120
Query: 121 NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT 180
NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT
Sbjct: 121 NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT 180
Query: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF 240
YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF
Sbjct: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF 240
Query: 241 FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI 300
FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI
Sbjct: 241 FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI 300
Query: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR
Sbjct: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ 420
MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ
Sbjct: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ 420
Query: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT 480
KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT
Sbjct: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT 480
Query: 481 KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG 540
KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG
Sbjct: 481 KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG 540
Query: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV 600
SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV
Sbjct: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV 600
Query: 601 QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE 660
QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE
Sbjct: 601 QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE 660
Query: 661 TCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 720
TCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH
Sbjct: 661 TCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 720
Query: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL
Sbjct: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
Query: 781 RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 840
RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV
Sbjct: 781 RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 840
Query: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW
Sbjct: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
Query: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ
Sbjct: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
Query: 961 WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA 1020
WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA
Sbjct: 961 WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA 1020
Query: 1021 REVYSVDPYNPAS 1033
REVYSVDPYNPAS
Sbjct: 1021 REVYSVDPYNPAS 1033
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 2153 bits (5578), Expect = 0.0
Identities = 1024/1093 (93%), Positives = 1028/1093 (94%), Gaps = 61/1093 (5%)
Query: 1 MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE 60
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE
Sbjct: 1 MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE 60
Query: 61 KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT 120
KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT
Sbjct: 61 KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT 120
Query: 121 NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT 180
NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT
Sbjct: 121 NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT 180
Query: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF 240
YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF
Sbjct: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF 240
Query: 241 FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI 300
FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI
Sbjct: 241 FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI 300
Query: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR
Sbjct: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ 420
MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ
Sbjct: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ 420
Query: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT 480
KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT
Sbjct: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT 480
Query: 481 KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG 540
KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG
Sbjct: 481 KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG 540
Query: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV 600
SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV
Sbjct: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV 600
Query: 601 QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE 660
QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK
Sbjct: 601 QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK- 659
Query: 661 TCQ------HVR----------------------------QSLQELPAG----------- 675
CQ H R +S+ +P+G
Sbjct: 660 GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEE 719
Query: 676 ---------------SRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 720
SRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH
Sbjct: 720 TCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 779
Query: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL
Sbjct: 780 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 839
Query: 781 RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 840
RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV
Sbjct: 840 RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 899
Query: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW
Sbjct: 900 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 959
Query: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ
Sbjct: 960 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 1019
Query: 961 WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA 1020
WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA
Sbjct: 1020 WNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEA 1079
Query: 1021 REVYSVDPYNPAS 1033
REVYSVDPYNPAS
Sbjct: 1080 REVYSVDPYNPAS 1092
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 581 bits (1498), Expect = e-165
Identities = 361/1046 (34%), Positives = 491/1046 (46%), Gaps = 122/1046 (11%)
Query: 21 ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73
I CG PP I NG IS G+V+ Y C+ F L+GE S+ C + D G
Sbjct: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGS-TPYRHGDSVTFACKTNFSMNGNKSVWC 132
W PAP+C NK C P V G + + + + + V F C+ F M G + V C
Sbjct: 1574 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
Query: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
QA N W P LP+C V C P I +G HT + + +PG V YSCE GY L G
Sbjct: 1631 QALNKWEP-ELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1685
Query: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
++C G WS P C C LG+ P+G+V P L++G +F CDEG+RL+G
Sbjct: 1686 ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGS 1745
Query: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
S CV+ G W +PVCE IFCP+PP ILNGRH G ++ YG ++YTCDP P+
Sbjct: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
Query: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQ--ILRGRMVSGQKDR 368
G+ F LIGEST+RCT D G WS PAPRCELS A C P+ +
Sbjct: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865
Query: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKECQAPPNILNGQKEDRHMV 427
+ ++ + C G+ K I C W C K C PP NG
Sbjct: 1866 FPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDT 1924
Query: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEG---VWTPPVPQCKVAACEATGRQLLTKPQH 484
+F G+++ YSCN G+ L+G S C G W P C++ +CE
Sbjct: 1925 QF--GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE------------ 1970
Query: 485 QFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLE 544
P S G+ Y ++
Sbjct: 1971 ----PPPTISNGDFY----------------------------------------SNNRT 1986
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
F GT VTY C+ GP+ F L+GE +I CTS D + G WS P P C + +C+
Sbjct: 1987 SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC---ISTNKCTA 2043
Query: 605 VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ- 663
+ N ++ G + + + + F+C GF + GS ++C+ + W P++P C + CQ
Sbjct: 2044 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR-VCQP 2102
Query: 664 -----HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIH 718
H +L S + V SC+ Y L G A C G W + P C V
Sbjct: 2103 PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC--TPQGDWSPEAPRCTVKS 2160
Query: 719 CHP-PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSP 777
C + +G+ ++ N G +VS+ CD+GF L G C W+ P
Sbjct: 2161 CDDFLGQLPHGR--VLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM-KALWNSSVP 2217
Query: 778 QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY-------VDCNPG----FIMNGSR 826
C + CPNP LN H+ DI Y D +P F + G
Sbjct: 2218 VCEQ----IFCPNPPA----ILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGES 2269
Query: 827 VIRCHTD----NTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQ 882
IRC +D W P C CP PPK NG++ GG+++ + PGM+I Y CD
Sbjct: 2270 SIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDP 2329
Query: 883 GYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECE 942
GYLLVG+ + CT +G WSQ +CKEVNCS P M+GI K LE +K+Y YG VTL+CE
Sbjct: 2330 GYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCE 2389
Query: 943 DGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHR 1002
DGY LEGSP SQCQ+D +W+PPLA C SR+ ++ G +G I LI+ ++I KHR
Sbjct: 2390 DGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHR 2449
Query: 1003 ARNYYTDTSQKEAFHLEAREVYSVDP 1028
N + ++ A HL ++ SV P
Sbjct: 2450 KGNNAHENPKEVAIHLHSQGGSSVHP 2475
Score = 560 bits (1444), Expect = e-159
Identities = 329/981 (33%), Positives = 483/981 (49%), Gaps = 70/981 (7%)
Query: 29 ILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKY 88
+LNGR+ + + +G + + C F+L G + C+ ++ W+ P CE
Sbjct: 815 LLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG-MESLWNSSVPVCEQI--- 869
Query: 89 SSCPEP-IVPGG-YKIRGSTPYRHGDSVTFACK------TNFSMNGNKSVWC----QANN 136
CP P ++P G + + + G +V + C T+F + G ++ C Q N
Sbjct: 870 -FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG 928
Query: 137 MWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI-I 195
+W + P C + + P + T N G S+ Y C Y G I
Sbjct: 929 VWS-SPAPRCGILGHCQAPD-HFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSI 984
Query: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
CL + WS+ C+ CK+ NG V ++VG N+ C G+RL G S+
Sbjct: 985 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 1044
Query: 256 CVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+++G W TK P+C+ I C PP I NG I + N YGS+VTY C+P
Sbjct: 1045 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 1104
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
F L+GE ++ CT + + G WSGPAP+C + +C P + G +VS + ++ N+
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPPNVENGILVSDNRSLFSLNEV 1161
Query: 375 VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTS 434
V F C GF +KG ++++C A WEP P C + CQ PP++L+ ++ R F PG
Sbjct: 1162 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 1221
Query: 435 IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK----PQHQFVRPD 490
+ YSC PGY L G S++CT +G W+P P C+V +C+ QLL P + +
Sbjct: 1222 VFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAK 1281
Query: 491 VNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
V+ C EG++L GS C W + +C++I CP PPVI NG HTG LE FP
Sbjct: 1282 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 1341
Query: 548 YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI 607
+G V YTC+P P+RG F LIGESTIRCTS+ Q G WS PAP C + H
Sbjct: 1342 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 1401
Query: 608 ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ---- 663
A K + + ++ ++C + + S I C + W VC++++C+
Sbjct: 1402 AK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPD 1459
Query: 664 ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC-QDAENGIWFKKIPLCKV 716
HV + ++ GSR +N SC G++L GH+ C W K P+C+
Sbjct: 1460 PVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQR 1513
Query: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHG 770
I C PP I NG ENF YG+ V+Y C+ G F L+GE + C S+ G
Sbjct: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
Query: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
WSGP+PQC+ +C P V++G ++ S +S N++V C PGF+M G R ++C
Sbjct: 1574 IWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
Query: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
N W P +P+C + C PPP+ +G HT + FSPG + YSC+ GY L G A
Sbjct: 1631 QALNKWEPELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
L CT +G WS AP C +C + L P + Q GA V+ C++G+ L+GS
Sbjct: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL-QLGAKVSFVCDEGFRLKGS 1745
Query: 951 PQSQC---QSDHQWNPPLAVC 968
S C WN + VC
Sbjct: 1746 SVSHCVLVGMRSLWNNSVPVC 1766
Score = 523 bits (1348), Expect = e-148
Identities = 292/825 (35%), Positives = 421/825 (51%), Gaps = 56/825 (6%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235
G + Y C GY II CL + W+ C C++ NG V ++ G
Sbjct: 66 GTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFG 124
Query: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
+ C +GYRL G S+ C+I+G V W + P+C+ I C PP I NG I + N
Sbjct: 125 SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNREN 184
Query: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354
YGS+VTY C+P F L+GE ++ CT + + G WSGPAP+C + +C P
Sbjct: 185 FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPP 241
Query: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414
+ G +VS + ++ N+ V F C GF +KG ++++C A WEP P C + CQ PP
Sbjct: 242 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
Query: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474
++L+ ++ R F PG + YSC PGY L G S++CT +G W+P P C+V +C+
Sbjct: 302 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
Query: 475 GRQLLTK----PQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527
QLL P + + V+ C EG++L GS C W + +C++I C
Sbjct: 362 MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 421
Query: 528 PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS 587
P PPVI NG HTG LE FP+G TV YTC+P P+RG F LIGESTIRCTS+ Q G WS
Sbjct: 422 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 588 GPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD 647
PAP C + H A K + + ++ ++C + + S I C +
Sbjct: 482 SPAPRCGILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDN 539
Query: 648 NTWDPEIPVCEKETCQ----------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQ 697
W VC++++C+ HV + ++ GSR +N SC G++L GH+
Sbjct: 540 LVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSA 593
Query: 698 MCQDAENGI-WFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG----- 751
C + N W K P+C+ I C PP I NG ENF YG+ V+Y C+ G
Sbjct: 594 ECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRK 653
Query: 752 -FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHND 810
F L+GE + C S+ G WSGP+PQC+ +C P V++G ++ S +S N+
Sbjct: 654 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNE 710
Query: 811 IVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARF 870
+V C PGF+M G R ++C N W P +P+C + C PPP + T + F
Sbjct: 711 VVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV----CQPPPDVLHAERTQRDKDNF 766
Query: 871 SPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM 930
SPG + YSC+ GY L G A + CT +G WS AP C+ +C D + + L R +
Sbjct: 767 SPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-----DFMGQLLNGRVL 821
Query: 931 Y----QYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968
+ Q GA V C++G+ L+GS S C + WN + VC
Sbjct: 822 FPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
Score = 434 bits (1116), Expect = e-121
Identities = 308/1009 (30%), Positives = 432/1009 (42%), Gaps = 101/1009 (10%)
Query: 21 ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCSG------TFRLIGEKSLLCITKDKVDG 73
I CG PP I NG IS G+V+ Y C+ F L+GE S+ C + D G
Sbjct: 164 IPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 223
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132
W PAP+C NK C P V G + + + + V F C+ F M G + V C
Sbjct: 224 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 280
Query: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
QA N W P LP+C V C P + + T + + +PG V YSCE GY L G
Sbjct: 281 QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
Query: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
+ C G WS PTCE C +G+ NG+V P L++G +F CDEG++L+G
Sbjct: 336 ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGS 395
Query: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
+S CV+AG W + +PVCE+IFCPSPP I NGRH G L +G V YTCDP P+
Sbjct: 396 SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
Query: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370
G +F LIGEST+RCT D Q G WS PAPRC + Q P + +
Sbjct: 456 RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI-LGHCQAPDHFLFAKLKTQTNASDFP 514
Query: 371 YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDRHMVR- 428
++ + C + + I C W VC+ K C+ PP+ +NG H++
Sbjct: 515 IGTSLKYECRPEYYGR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV---HVITD 570
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEG---VWTPPVPQCKVAACE-----ATGRQLLT 480
G+ I YSC G+ L+G S +C G W+ P C+ C A G + T
Sbjct: 571 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 630
Query: 481 KPQHQFVRPDVNSSCGEG------YKLSGSVYQECQGTIP----WFMEIRLCKEITCPPP 530
++ V C G ++L G C W C P
Sbjct: 631 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 690
Query: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA 590
P + NG + F V + C PG F + G ++C Q W
Sbjct: 691 PNVENGILVSDNRSLFSLNEVVEFRCQPG------FVMKGPRRVKC----QALNKWEPEL 740
Query: 591 PLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTW 650
P C V + + + + + V + C G+ L+G++ +RC W
Sbjct: 741 PSCS----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 796
Query: 651 DPEIPVCEKETCQHVRQSL--------QELPAGSRVELVNTSCQDGYQLTGHAYQMCQDA 702
P P CE ++C L L G++V+ V C +G+QL G + C A
Sbjct: 797 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV---CDEGFQLKGSSASYCVLA 853
Query: 703 -ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD------QGFYLL 755
+W +P+C+ I C PPVI NG+HTG E F +G V+Y CD F L+
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 913
Query: 756 GEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE--VKHGYKLNKTHSAYSHNDIVY 813
GE ++C SD +G+G WS P+P+C + C P+ + K S + +
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 814 VDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HTGGNIARFSP 872
+C P + I C + W C +K+ C PP NG H I
Sbjct: 971 YECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKS---CKTPPDPVNGMVHV---ITDIQV 1023
Query: 873 GMSILYSCDQGYLLVGEALLLCTHEGT---WSQPAPHCKEVNCSSPADMDGIQKGLEPRK 929
G I YSC G+ L+G + C G WS P C+ + C P + R+
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1083
Query: 930 MYQYGAVVTLECEDG------YMLEGSPQSQCQSDHQ----WNPPLAVC 968
+ YG+VVT C G + L G P C S+ W+ P C
Sbjct: 1084 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 1132
Score = 325 bits (834), Expect = 1e-88
Identities = 302/1093 (27%), Positives = 429/1093 (39%), Gaps = 214/1093 (19%)
Query: 21 ISCGSPPPILNGRISYYSTPIAV---GTVIRYSCS-----GT-FRLIGEKSLLCITKDKV 71
I C SPP I NGR + P+ V G + Y+C GT F LIGE ++ C + +
Sbjct: 1319 IFCPSPPVIPNGR--HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 1376
Query: 72 DGTWDKPAPKC--------------------------------------EYFNKYSS--- 90
+G W PAP+C EY+ + S
Sbjct: 1377 NGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITC 1436
Query: 91 -----------------CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC- 132
C P P + T + G + ++C T + G+ S C
Sbjct: 1437 LDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECI 1496
Query: 133 -QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESG----- 186
N T+ P C + C P I NG S N + G VTY C G
Sbjct: 1497 LSGNTAHWSTKPPICQRI---PCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRK 1553
Query: 187 -YLLVGEKIINCLSS----GKWSAVPPTCEEARCKSLGRFPNGKV--KEPPILRVGVTAN 239
+ LVGE I C S+ G WS P C + NG + + +
Sbjct: 1554 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 1613
Query: 240 FFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYG 298
F C G+ ++GP +C + W ++P C + C PP IL+G H + N S G
Sbjct: 1614 FRCQPGFVMKGPRRVKCQALNK---WEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPG 1669
Query: 299 SIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTS---AVQCPHPQ 355
V Y+C+P + L G ++L CT G WS APRC + + Q PH +
Sbjct: 1670 QEVFYSCEP------GYDLRGAASLHCT----PQGDWSPEAPRCAVKSCDDFLGQLPHGR 1719
Query: 356 ILRG-RMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWEPSAPVCEK-EC 410
+L + G K V F C GF LKGS C + W S PVCE C
Sbjct: 1720 VLFPLNLQLGAK--------VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFC 1771
Query: 411 QAPPNILNGQKEDRHMVRFDPGTSIKYSCNP------GYVLVGEESIQCTSE----GVWT 460
PP ILNG+ G I Y+C+P + L+GE +I+CTS+ GVW+
Sbjct: 1772 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1831
Query: 461 PPVPQCKVAACEATGRQLLTKPQHQFVRPDV-------------NSSCGEGYKLSGSVYQ 507
P P+C+++ T Q F P + N C GY G ++
Sbjct: 1832 SPAPRCELS---VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY--FGKMFS 1886
Query: 508 -ECQGTIPWFMEIRLCKEITCPPPPVIYNG-AHTGSSLEDFPYGTTVTYTCNPGPERGVE 565
C + W C+ +C PPP +NG H + D +G+TV Y+CN G
Sbjct: 1887 ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT---DTQFGSTVNYSCNEG------ 1937
Query: 566 FSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCS-HVHIANGYKISGKEAPYFYND 624
F LIG + C + TW AP+C++ + C I+NG S +
Sbjct: 1938 FRLIGSPSTTCLVSG-NNVTWDKKAPICEI----ISCEPPPTISNGDFYSNNRTSFHNGT 1992
Query: 625 TVTFKCYSG------FTLKGSSQIRCKADN----TWDPEIPVC---EKETCQHVRQSLQE 671
VT++C++G F L G I C + + W P C K T V +++
Sbjct: 1993 VVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIR- 2051
Query: 672 LPAG----SRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVN 727
+P + E++ CQ G+ + G CQ NG W K+P C + C PPP I++
Sbjct: 2052 VPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ--TNGRWGPKLPHCSRV-CQPPPEILH 2108
Query: 728 GKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTR 787
G+HT +NF G EV Y C+ + L G L C G WS +P+C V
Sbjct: 2109 GEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTP----QGDWSPEAPRC----TVKS 2160
Query: 788 CPN--PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC---HTDNTWVPGVPT 842
C + ++ HG L + V C+ GF + G C W VP
Sbjct: 2161 CDDFLGQLPHGRVLLPLNLQLGAK--VSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV 2218
Query: 843 CIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD------QGYLLVGEALLLCTH 896
C + I CP PP NG HTG G I Y+CD + L+GE+ + CT
Sbjct: 2219 CEQ---IFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTS 2275
Query: 897 E----GTWSQPAPHCK---EVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEG 949
+ G WS PAP C+ C P + +Y G ++ C+ GY+L G
Sbjct: 2276 DPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVG 2335
Query: 950 SPQSQCQSDHQWN 962
C W+
Sbjct: 2336 KGFIFCTDQGIWS 2348
Score = 256 bits (654), Expect = 8e-68
Identities = 257/1046 (24%), Positives = 397/1046 (37%), Gaps = 153/1046 (14%)
Query: 23 CGSPPPILNG-RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
C PP +L+ R + G + YSC + L G S+ C + G W AP
Sbjct: 297 CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ----GDWSPAAPT 352
Query: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPY----RHGDSVTFACKTNFSMNGNKSVWCQANNM 137
CE SC + + G + G + + G V F C F + G+ + +C M
Sbjct: 353 CEV----KSCDDFM---GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 138 ---WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCE------SGYL 188
W + +P C +F CP+ P+I NG HT + + G +V Y+C+ + +
Sbjct: 406 ESLWNSS-VPVCEQIF---CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461
Query: 189 LVGEKIINCLS----SGKWSAVPPTCEE-ARCKSLGRFPNGKVK---EPPILRVGVTANF 240
L+GE I C S +G WS+ P C C++ F K+K +G + +
Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521
Query: 241 FCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGR-HIGNSLANVSYG 298
C Y G P S + + W+ VC+ C +PP +NG H+ + ++ G
Sbjct: 522 ECRPEY--YGRPFS--ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVG 574
Query: 299 SIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILR 358
S + Y+C LIG S+ C + S WS P C+ + P I
Sbjct: 575 SRINYSCTTGHR------LIGHSSAECIL-SGNAAHWSTKPPICQRIPCGLP---PTIAN 624
Query: 359 GRMVSGQKDRYTYNDTVIFACMFG------FTLKGSKQIRCNAQ----GTWEPSAPVC-- 406
G +S ++ + Y V + C G F L G I C + G W AP C
Sbjct: 625 GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 684
Query: 407 EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
+C PPN+ NG + F +++ C PG+V+ G ++C + W P +P C
Sbjct: 685 PNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
Query: 467 K--------VAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFME 518
V E T R Q +V SC GY L G+ C W
Sbjct: 744 SRVCQPPPDVLHAERTQRDKDNFSPGQ----EVFYSCEPGYDLRGAASMRCTPQGDWSPA 799
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSL---EDFPYGTTVTYTCNPGPERGVEFSLIGESTIR 575
C+ +C + G + + G V + C+ G F L G S
Sbjct: 800 APTCEVKSCDD----FMGQLLNGRVLFPVNLQLGAKVDFVCDEG------FQLKGSSASY 849
Query: 576 CTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYF-YNDTVTFKCY--- 631
C E W+ P+C+ + C + + +GK F + TV + C
Sbjct: 850 CVLAGME-SLWNSSVPVCE----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHP 904
Query: 632 ---SGFTLKGSSQIRCKAD----NTWDPEIPVCE-KETCQ----------HVRQSLQELP 673
+ F L G S IRC +D W P C CQ + + + P
Sbjct: 905 DRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFP 964
Query: 674 AGSRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTG 732
G+ ++ C+ Y G + + C D N +W +CK C PP VNG
Sbjct: 965 IGTSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDPVNGMVH- 1016
Query: 733 MMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPPVTRCP-N 790
+ + G+ ++Y C G L+G +C S + H WS P C R P C
Sbjct: 1017 -VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP----CGLP 1069
Query: 791 PEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGV 840
P + +G ++ + + +V CNPG F + G I C +++ W
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129
Query: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
P CI PP NG N + FS + + C G+++ G + C W
Sbjct: 1130 PQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 1186
Query: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
P C V C P D+ ++ + + G V CE GY L G+ +C
Sbjct: 1187 EPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 1245
Query: 961 WNPPLAVCRSRSLAPVLCGIAAGLIL 986
W+P C +S + + G +L
Sbjct: 1246 WSPAAPTCEVKSCDDFMGQLLNGRVL 1271
Score = 229 bits (584), Expect = 1e-59
Identities = 176/589 (29%), Positives = 252/589 (42%), Gaps = 67/589 (11%)
Query: 404 PVCEKECQAP-------PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE-SIQCTS 455
PV +C AP P L + E F GT + Y C PGY G SI C
Sbjct: 37 PVAWGQCNAPEWLPFARPTNLTDEFE------FPIGTYLNYECRPGY--SGRPFSIICLK 88
Query: 456 EGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC-- 509
VWT +C+ +C + + QF + SC +GY+L GS C
Sbjct: 89 NSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSATCII 147
Query: 510 -QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568
T+ W E +C I C PP I NG ++ E+F YG+ VTY CNPG F L
Sbjct: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFEL 207
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTF 628
+GE +I CTSND + G WSGPAP C ++ +C+ ++ NG +S + + N+ V F
Sbjct: 208 VGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
Query: 629 KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ------HVRQSLQELPAGSRVELVN 682
+C GF +KG +++C+A N W+PE+P C + CQ H ++ ++ S + V
Sbjct: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSR-VCQPPPDVLHAERTQRDKDNFSPGQEVF 323
Query: 683 TSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP-PPVIVNGKHTGMMAENFLYG 741
SC+ GY L G A C G W P C+V C ++NG+ + N G
Sbjct: 324 YSCEPGYDLRGAASMRC--TPQGDWSPAAPTCEVKSCDDFMGQLLNGR--VLFPVNLQLG 379
Query: 742 NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLN 800
+V + CD+GF L G C W+ P C + CP+P V +G
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCEQ----IFCPSPPVIPNGRHTG 434
Query: 801 KTHSAYSHNDIVYVDCNP------GFIMNGSRVIRCHTD----NTWVPGVPTCIKKAFIG 850
K + V C+P F + G IRC +D W P C +G
Sbjct: 435 KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---GILG 491
Query: 851 -CPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVGEAL-LLCTHEGTWSQPAPHC 907
C P T N + F G S+ Y C Y G + C WS P C
Sbjct: 492 HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVC 549
Query: 908 KEVNCSSPAD-MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC 955
K +C +P D ++G+ + Q G+ + C G+ L G ++C
Sbjct: 550 KRKSCKTPPDPVNGMVHVITD---IQVGSRINYSCTTGHRLIGHSSAEC 595
Score = 198 bits (503), Expect = 2e-50
Identities = 198/813 (24%), Positives = 302/813 (37%), Gaps = 116/813 (14%)
Query: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGR-HIGNS 291
+G N+ C GY G P S +I + WT C C +PP +NG H+
Sbjct: 65 IGTYLNYECRPGY--SGRPFS--IICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV--- 117
Query: 292 LANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC 351
+ + +GS + Y+C + LIG S+ C + S T W P C+ +
Sbjct: 118 IKGIQFGSQIKYSCTK------GYRLIGSSSATCII-SGDTVIWDNETPICDRIPCGLP- 169
Query: 352 PHPQILRGRMVSGQKDRYTYNDTVIFACMFG------FTLKGSKQIRCNAQ----GTWEP 401
P I G +S ++ + Y V + C G F L G I C + G W
Sbjct: 170 --PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 227
Query: 402 SAPVC--EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVW 459
AP C +C PPN+ NG + F +++ C PG+V+ G ++C + W
Sbjct: 228 PAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 286
Query: 460 TPPVPQCK--------VAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQG 511
P +P C V E T R Q +V SC GY L G+ C
Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ----EVFYSCEPGYDLRGAASMRCTP 342
Query: 512 TIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL---EDFPYGTTVTYTCNPGPERGVEFSL 568
W C+ +C + G + + G V + C+ G F L
Sbjct: 343 QGDWSPAAPTCEVKSCDD----FMGQLLNGRVLFPVNLQLGAKVDFVCDEG------FQL 392
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYF-YNDTVT 627
G S C E W+ P+C+ + C + + +GK F + TV
Sbjct: 393 KGSSASYCVLAGME-SLWNSSVPVCE----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVN 447
Query: 628 FKCY------SGFTLKGSSQIRCKAD----NTWDPEIPVCE-KETCQ----------HVR 666
+ C + F L G S IRC +D W P C CQ +
Sbjct: 448 YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQ 507
Query: 667 QSLQELPAGSRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVI 725
+ + P G+ ++ C+ Y G + + C D N +W +CK C PP
Sbjct: 508 TNASDFPIGTSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDP 560
Query: 726 VNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPP 784
VNG + + G+ ++Y C G L+G +C S + H WS P C R P
Sbjct: 561 VNGMVH--VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP- 615
Query: 785 VTRCP-NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT-- 835
C P + +G ++ + + +V CNPG F + G I C +++
Sbjct: 616 ---CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 836 --WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLL 893
W P CI PP NG N + FS + + C G+++ G +
Sbjct: 673 GIWSGPAPQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 894 CTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS 953
C W P C V C P D+ ++ + + G V CE GY L G+
Sbjct: 730 CQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 788
Query: 954 QCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLIL 986
+C W+P C +S + + G +L
Sbjct: 789 RCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL 821
Score = 133 bits (335), Expect = 8e-31
Identities = 113/468 (24%), Positives = 179/468 (38%), Gaps = 86/468 (18%)
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
+FP GT + Y C PG G FS+I C N W+G C+ C +
Sbjct: 62 EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTGAKDRCRRK----SCRN 106
Query: 605 --------VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN---TWDPE 653
VH+ G + + + + C G+ L GSS C WD E
Sbjct: 107 PPDPVNGMVHVIKGIQ---------FGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
Query: 654 IPVCEKETC---------QHVRQSLQELPAGSRVELVNTSCQDG------YQLTGHAYQM 698
P+C++ C + + + GS +V C G ++L G
Sbjct: 158 TPICDRIPCGLPPTITNGDFISTNRENFHYGS---VVTYRCNPGSGGRKVFELVGEPSIY 214
Query: 699 C--QDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLG 756
C D + GIW P C + + PP + NG F V + C GF + G
Sbjct: 215 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 274
Query: 757 EKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDC 816
++++C++ +K W P C R P P+V H + + +S V+ C
Sbjct: 275 PRRVKCQALNK----WEPELPSCSR----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 326
Query: 817 NPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA---FIGCPPPPKTPNGNHTGGNIARFSPG 873
PG+ + G+ +RC W P PTC K+ F+G + NG G
Sbjct: 327 EPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMG-----QLLNGRVLFP--VNLQLG 379
Query: 874 MSILYSCDQGYLLVGEALLLCT---HEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM 930
+ + CD+G+ L G + C E W+ P C+++ C SP + + +P ++
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 439
Query: 931 YQYGAVVTLECE------DGYMLEGSPQSQCQSDHQ----WNPPLAVC 968
+ +G V C+ + L G +C SD Q W+ P C
Sbjct: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
Score = 100 bits (249), Expect = 7e-21
Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 28/327 (8%)
Query: 671 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 730
E P G+ +N C+ GY +G + + +N +W C+ C PP VNG
Sbjct: 62 EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115
Query: 731 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP- 789
+ + +G+++ Y C +G+ L+G C S W +P C R P C
Sbjct: 116 H--VIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWDNETPICDRIP----CGL 168
Query: 790 NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPG 839
P + +G ++ + + +V CNPG F + G I C +++ W
Sbjct: 169 PPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 228
Query: 840 VPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT 899
P CI PP NG N + FS + + C G+++ G + C
Sbjct: 229 APQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
Query: 900 WSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH 959
W P C V C P D+ ++ + + G V CE GY L G+ +C
Sbjct: 286 WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
Query: 960 QWNPPLAVCRSRSLAPVLCGIAAGLIL 986
W+P C +S + + G +L
Sbjct: 345 DWSPAAPTCEVKSCDDFMGQLLNGRVL 371
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 560 bits (1444), Expect = e-159
Identities = 329/981 (33%), Positives = 483/981 (49%), Gaps = 70/981 (7%)
Query: 29 ILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKY 88
+LNGR+ + + +G + + C F+L G + C+ ++ W+ P CE
Sbjct: 365 LLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG-MESLWNSSVPVCEQI--- 419
Query: 89 SSCPEP-IVPGG-YKIRGSTPYRHGDSVTFACK------TNFSMNGNKSVWC----QANN 136
CP P ++P G + + + G +V + C T+F + G ++ C Q N
Sbjct: 420 -FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG 478
Query: 137 MWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI-I 195
+W + P C + + P + T N G S+ Y C Y G I
Sbjct: 479 VWS-SPAPRCGILGHCQAPD-HFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSI 534
Query: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
CL + WS+ C+ CK+ NG V ++VG N+ C G+RL G S+
Sbjct: 535 TCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594
Query: 256 CVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+++G W TK P+C+ I C PP I NG I + N YGS+VTY C+P
Sbjct: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV 654
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
F L+GE ++ CT + + G WSGPAP+C + +C P + G +VS + ++ N+
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPPNVENGILVSDNRSLFSLNEV 711
Query: 375 VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTS 434
V F C GF +KG ++++C A WEP P C + CQ PP++L+ ++ R F PG
Sbjct: 712 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771
Query: 435 IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTK----PQHQFVRPD 490
+ YSC PGY L G S++CT +G W+P P C+V +C+ QLL P + +
Sbjct: 772 VFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAK 831
Query: 491 VNSSCGEGYKLSGSVYQECQGT---IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
V+ C EG++L GS C W + +C++I CP PPVI NG HTG LE FP
Sbjct: 832 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFP 891
Query: 548 YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI 607
+G V YTC+P P+RG F LIGESTIRCTS+ Q G WS PAP C + H
Sbjct: 892 FGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLF 951
Query: 608 ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ---- 663
A K + + ++ ++C + + S I C + W VC++++C+
Sbjct: 952 AK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPD 1009
Query: 664 ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC-QDAENGIWFKKIPLCKV 716
HV + ++ GSR +N SC G++L GH+ C W K P+C+
Sbjct: 1010 PVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQR 1063
Query: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHG 770
I C PP I NG ENF YG+ V+Y C+ G F L+GE + C S+ G
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
WSGP+PQC+ +C P V++G ++ S +S N++V C PGF+M G R ++C
Sbjct: 1124 IWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180
Query: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
N W P +P+C + C PPP+ +G HT + FSPG + YSC+ GY L G A
Sbjct: 1181 QALNKWEPELPSCSRV----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1236
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
L CT +G WS AP C +C + L P + Q GA V+ C++G+ L+GS
Sbjct: 1237 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL-QLGAKVSFVCDEGFRLKGS 1295
Query: 951 PQSQC---QSDHQWNPPLAVC 968
S C WN + VC
Sbjct: 1296 SVSHCVLVGMRSLWNNSVPVC 1316
Score = 523 bits (1348), Expect = e-148
Identities = 292/825 (35%), Positives = 421/825 (51%), Gaps = 56/825 (6%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235
G + Y C GY II CL + W+ C C++ NG V ++ G
Sbjct: 66 GTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFG 124
Query: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
+ C +GYRL G S+ C+I+G V W + P+C+ I C PP I NG I + N
Sbjct: 125 SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNREN 184
Query: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354
YGS+VTY C+P F L+GE ++ CT + + G WSGPAP+C + +C P
Sbjct: 185 FHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN---KCTPP 241
Query: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414
+ G +VS + ++ N+ V F C GF +KG ++++C A WEP P C + CQ PP
Sbjct: 242 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301
Query: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474
++L+ ++ R F PG + YSC PGY L G S++CT +G W+P P C+V +C+
Sbjct: 302 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361
Query: 475 GRQLLTK----PQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527
QLL P + + V+ C EG++L GS C W + +C++I C
Sbjct: 362 MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 421
Query: 528 PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS 587
P PPVI NG HTG LE FP+G TV YTC+P P+RG F LIGESTIRCTS+ Q G WS
Sbjct: 422 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 588 GPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD 647
PAP C + H A K + + ++ ++C + + S I C +
Sbjct: 482 SPAPRCGILGHCQAPDHFLFAK-LKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDN 539
Query: 648 NTWDPEIPVCEKETCQ----------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQ 697
W VC++++C+ HV + ++ GSR +N SC G++L GH+
Sbjct: 540 LVWSSPKDVCKRKSCKTPPDPVNGMVHV---ITDIQVGSR---INYSCTTGHRLIGHSSA 593
Query: 698 MCQDAENGI-WFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG----- 751
C + N W K P+C+ I C PP I NG ENF YG+ V+Y C+ G
Sbjct: 594 ECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRK 653
Query: 752 -FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHND 810
F L+GE + C S+ G WSGP+PQC+ +C P V++G ++ S +S N+
Sbjct: 654 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNE 710
Query: 811 IVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARF 870
+V C PGF+M G R ++C N W P +P+C + C PPP + T + F
Sbjct: 711 VVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV----CQPPPDVLHAERTQRDKDNF 766
Query: 871 SPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM 930
SPG + YSC+ GY L G A + CT +G WS AP C+ +C D + + L R +
Sbjct: 767 SPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-----DFMGQLLNGRVL 821
Query: 931 Y----QYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968
+ Q GA V C++G+ L+GS S C + WN + VC
Sbjct: 822 FPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
Score = 466 bits (1200), Expect = e-131
Identities = 335/1070 (31%), Positives = 476/1070 (44%), Gaps = 110/1070 (10%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC +PP +NG + + T I VG+ I YSC+ RLIG S CI W P
Sbjct: 1003 SCKTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNT-AHWSTKPPI 1060
Query: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTN------FSMNGNKSVWCQAN 135
C+ P I G + + +G VT+ C F + G S++C +N
Sbjct: 1061 CQRIP--CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSN 1118
Query: 136 N----MW-GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV 190
+ +W GP P C+ P +C P + NG S+N + V + C+ G+++
Sbjct: 1119 DDQVGIWSGPA--PQCI--IPNKCTP-PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMK 1173
Query: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCDEGYRL 248
G + + C + KW P+C C+ +G+ G + C+ GY L
Sbjct: 1174 GPRRVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDL 1232
Query: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSL--ANVSYGSIVTYTC 305
+G S C G W+ + P C C L G L N+ G+ V++ C
Sbjct: 1233 RGAASLHCTPQGD---WSPEAPRCAVKSCDD---FLGQLPHGRVLFPLNLQLGAKVSFVC 1286
Query: 306 DPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQ-ILRGRMVSG 364
D EG F L G S C + ++ W+ P CE + CP+P IL GR
Sbjct: 1287 D----EG--FRLKGSSVSHCVLVGMRS-LWNNSVPVCE----HIFCPNPPAILNGRHTGT 1335
Query: 365 QKDRYTYNDTVIFACM------FGFTLKGSKQIRCNAQ----GTWEPSAPVCEKE----- 409
Y + + C F L G IRC + G W AP CE
Sbjct: 1336 PSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGH 1395
Query: 410 CQAPPNI-LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCK 467
C+ P + F GTS+ Y C PGY G+ SI C VW+ C+
Sbjct: 1396 CKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF--GKMFSISCLENLVWSSVEDNCR 1453
Query: 468 VAAC----EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ---GTIPWFMEIR 520
+C E + QF VN SC EG++L GS C + W +
Sbjct: 1454 RKSCGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAP 1512
Query: 521 LCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
+C+ I+C PPP I NG ++ F GT VTY C+ GP+ F L+GE +I CTS D
Sbjct: 1513 ICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKD 1572
Query: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSS 640
+ G WS P P C + +C+ + N ++ G + + + + F+C GF + GS
Sbjct: 1573 DQVGVWSSPPPRC---ISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSH 1629
Query: 641 QIRCKADNTWDPEIPVCEKETCQ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGH 694
++C+ + W P++P C + CQ H +L S + V SC+ Y L G
Sbjct: 1630 TVQCQTNGRWGPKLPHCSR-VCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 1688
Query: 695 AYQMCQDAENGIWFKKIPLCKVIHCHP-PPVIVNGKHTGMMAENFLYGNEVSYECDQGFY 753
A C G W + P C V C + +G+ ++ N G +VS+ CD+GF
Sbjct: 1689 ASLHC--TPQGDWSPEAPRCTVKSCDDFLGQLPHGRV--LLPLNLQLGAKVSFVCDEGFR 1744
Query: 754 LLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY 813
L G C W+ P C + CPNP LN H+ DI Y
Sbjct: 1745 LKGRSASHCVLAGM-KALWNSSVPVCEQ----IFCPNPPAI----LNGRHTGTPFGDIPY 1795
Query: 814 -------VDCNPG----FIMNGSRVIRCHTD----NTWVPGVPTCIKKAFIGCPPPPKTP 858
D +P F + G IRC +D W P C CP PPK
Sbjct: 1796 GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQ 1855
Query: 859 NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 918
NG++ GG+++ + PGM+I Y CD GYLLVG+ + CT +G WSQ +CKEVNCS P M
Sbjct: 1856 NGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM 1915
Query: 919 DGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLC 978
+GI K LE +K+Y YG VTL+CEDGY LEGSP SQCQ+D +W+PPLA C SR+ ++
Sbjct: 1916 NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIV 1975
Query: 979 GIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDP 1028
G +G I LI+ ++I KHR N + ++ A HL ++ SV P
Sbjct: 1976 GTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHP 2025
Score = 433 bits (1113), Expect = e-121
Identities = 308/1009 (30%), Positives = 432/1009 (42%), Gaps = 101/1009 (10%)
Query: 21 ISCGSPPPILNGR-ISYYSTPIAVGTVIRYSCSG------TFRLIGEKSLLCITKDKVDG 73
I CG PP I NG IS G+V+ Y C+ F L+GE S+ C + D G
Sbjct: 164 IPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 223
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWC 132
W PAP+C NK C P V G + + + + V F C+ F M G + V C
Sbjct: 224 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 280
Query: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
QA N W P LP+C V C P + + T + + +PG V YSCE GY L G
Sbjct: 281 QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGA 335
Query: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
+ C G WS PTCE C +G+ NG+V P L++G +F CDEG++L+G
Sbjct: 336 ASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGS 395
Query: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
+S CV+AG W + +PVCE+IFCPSPP I NGRH G L +G V YTCDP P+
Sbjct: 396 SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
Query: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370
G +F LIGEST+RCT D Q G WS PAPRC + Q P + +
Sbjct: 456 RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI-LGHCQAPDHFLFAKLKTQTNASDFP 514
Query: 371 YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDRHMVR- 428
++ + C + + I C W VC+ K C+ PP+ +NG H++
Sbjct: 515 IGTSLKYECRPEYYGR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV---HVITD 570
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEG---VWTPPVPQCKVAACE-----ATGRQLLT 480
G+ I YSC G+ L+G S +C G W+ P C+ C A G + T
Sbjct: 571 IQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIST 630
Query: 481 KPQHQFVRPDVNSSCGEG------YKLSGSVYQECQGTIP----WFMEIRLCKEITCPPP 530
++ V C G ++L G C W C P
Sbjct: 631 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 690
Query: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA 590
P + NG + F V + C PG F + G ++C Q W
Sbjct: 691 PNVENGILVSDNRSLFSLNEVVEFRCQPG------FVMKGPRRVKC----QALNKWEPEL 740
Query: 591 PLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTW 650
P C V + + + + + V + C G+ L+G++ +RC W
Sbjct: 741 PSCS----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 796
Query: 651 DPEIPVCEKETCQHVRQSL--------QELPAGSRVELVNTSCQDGYQLTGHAYQMCQDA 702
P P CE ++C L L G++V+ V C +G+QL G + C A
Sbjct: 797 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV---CDEGFQLKGSSASYCVLA 853
Query: 703 -ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD------QGFYLL 755
+W +P+C+ I C PPVI NG+HTG E F +G V+Y CD F L+
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 913
Query: 756 GEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE--VKHGYKLNKTHSAYSHNDIVY 813
GE ++C SD +G+G WS P+P+C + C P+ + K S + +
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 814 VDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HTGGNIARFSP 872
+C P + I C + W C +K+ C PP NG H I
Sbjct: 971 YECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKS---CKTPPDPVNGMVHV---ITDIQV 1023
Query: 873 GMSILYSCDQGYLLVGEALLLCTHEGT---WSQPAPHCKEVNCSSPADMDGIQKGLEPRK 929
G I YSC G+ L+G + C G WS P C+ + C P + R+
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1083
Query: 930 MYQYGAVVTLECEDG------YMLEGSPQSQCQSDHQ----WNPPLAVC 968
+ YG+VVT C G + L G P C S+ W+ P C
Sbjct: 1084 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 1132
Score = 229 bits (584), Expect = 1e-59
Identities = 176/589 (29%), Positives = 252/589 (42%), Gaps = 67/589 (11%)
Query: 404 PVCEKECQAP-------PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE-SIQCTS 455
PV +C AP P L + E F GT + Y C PGY G SI C
Sbjct: 37 PVAWGQCNAPEWLPFARPTNLTDEFE------FPIGTYLNYECRPGY--SGRPFSIICLK 88
Query: 456 EGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC-- 509
VWT +C+ +C + + QF + SC +GY+L GS C
Sbjct: 89 NSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSATCII 147
Query: 510 -QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568
T+ W E +C I C PP I NG ++ E+F YG+ VTY CNPG F L
Sbjct: 148 SGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFEL 207
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTF 628
+GE +I CTSND + G WSGPAP C ++ +C+ ++ NG +S + + N+ V F
Sbjct: 208 VGEPSIYCTSNDDQVGIWSGPAPQC---IIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
Query: 629 KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ------HVRQSLQELPAGSRVELVN 682
+C GF +KG +++C+A N W+PE+P C + CQ H ++ ++ S + V
Sbjct: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSR-VCQPPPDVLHAERTQRDKDNFSPGQEVF 323
Query: 683 TSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP-PPVIVNGKHTGMMAENFLYG 741
SC+ GY L G A C G W P C+V C ++NG+ + N G
Sbjct: 324 YSCEPGYDLRGAASMRC--TPQGDWSPAAPTCEVKSCDDFMGQLLNGR--VLFPVNLQLG 379
Query: 742 NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLN 800
+V + CD+GF L G C W+ P C + CP+P V +G
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCEQ----IFCPSPPVIPNGRHTG 434
Query: 801 KTHSAYSHNDIVYVDCNP------GFIMNGSRVIRCHTD----NTWVPGVPTCIKKAFIG 850
K + V C+P F + G IRC +D W P C +G
Sbjct: 435 KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---GILG 491
Query: 851 -CPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLLVGEAL-LLCTHEGTWSQPAPHC 907
C P T N + F G S+ Y C Y G + C WS P C
Sbjct: 492 HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVC 549
Query: 908 KEVNCSSPAD-MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC 955
K +C +P D ++G+ + Q G+ + C G+ L G ++C
Sbjct: 550 KRKSCKTPPDPVNGMVHVITD---IQVGSRINYSCTTGHRLIGHSSAEC 595
Score = 202 bits (513), Expect = 2e-51
Identities = 196/692 (28%), Positives = 271/692 (39%), Gaps = 164/692 (23%)
Query: 21 ISCGSPPPILNGRISYYSTP---IAVGTVIRYSCSG------TFRLIGEKSLLCITKDKV 71
I C +PP ILNGR + TP I G I Y+C TF LIGE ++ C +
Sbjct: 1319 IFCPNPPAILNGR--HTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG 1376
Query: 72 DGTWDKPAPKCE-----------------------------------------YFNKYSS 90
+G W PAP+CE YF K S
Sbjct: 1377 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS 1436
Query: 91 --------------------CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSV 130
C P P + +T + G +V ++C F + G+ S
Sbjct: 1437 ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPST 1496
Query: 131 WC--QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESG-- 186
C NN+ + P C + C P I NG S N S G VTY C +G
Sbjct: 1497 TCLVSGNNVTWDKKAPICEII---SCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPD 1553
Query: 187 ----YLLVGEKIINCLSS----GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTA 238
+ LVGE+ I C S G WS+ PP RC S + +V+ +RV
Sbjct: 1554 GEQLFELVGERSIYCTSKDDQVGVWSSPPP-----RCISTNKCTAPEVEN--AIRVPGNR 1606
Query: 239 NFF---------CDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHI 288
+FF C G+ + G + +C G+ W K+P C + C PP IL+G H
Sbjct: 1607 SFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGR---WGPKLPHCSRV-CQPPPEILHGEHT 1662
Query: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTS- 347
+ N S G V Y+C+P ++ L G ++L CT G WS APRC + +
Sbjct: 1663 LSHQDNFSPGQEVFYSCEP------SYDLRGAASLHCT----PQGDWSPEAPRCTVKSCD 1712
Query: 348 --AVQCPHPQILRG-RMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQG---TWEP 401
Q PH ++L + G K V F C GF LKG C G W
Sbjct: 1713 DFLGQLPHGRVLLPLNLQLGAK--------VSFVCDEGFRLKGRSASHCVLAGMKALWNS 1764
Query: 402 SAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP------GYVLVGEESIQCT 454
S PVCE+ C PP ILNG+ G I Y+C+ + L+GE SI+CT
Sbjct: 1765 SVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCT 1824
Query: 455 SE----GVWTPPVPQCKV---AACE-----ATGRQLLTKPQHQFVRPDVNSSCGEGYKLS 502
S+ GVW+ P P+C++ AAC G + ++ C GY L
Sbjct: 1825 SDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLV 1884
Query: 503 GSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLED-FPYGTTVTYTCNPGPE 561
G + C W CKE+ C P+ NG ++ + YG VT C G
Sbjct: 1885 GKGFIFCTDQGIWSQLDHYCKEVNC-SFPLFMNGISKELEMKKVYHYGDYVTLKCEDG-- 1941
Query: 562 RGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593
++L G +C ++D+ W P C
Sbjct: 1942 ----YTLEGSPWSQCQADDR----WDPPLAKC 1965
Score = 198 bits (503), Expect = 2e-50
Identities = 198/813 (24%), Positives = 302/813 (37%), Gaps = 116/813 (14%)
Query: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGR-HIGNS 291
+G N+ C GY G P S +I + WT C C +PP +NG H+
Sbjct: 65 IGTYLNYECRPGY--SGRPFS--IICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV--- 117
Query: 292 LANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC 351
+ + +GS + Y+C + LIG S+ C + S T W P C+ +
Sbjct: 118 IKGIQFGSQIKYSCTK------GYRLIGSSSATCII-SGDTVIWDNETPICDRIPCGLP- 169
Query: 352 PHPQILRGRMVSGQKDRYTYNDTVIFACMFG------FTLKGSKQIRCNAQ----GTWEP 401
P I G +S ++ + Y V + C G F L G I C + G W
Sbjct: 170 --PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 227
Query: 402 SAPVC--EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVW 459
AP C +C PPN+ NG + F +++ C PG+V+ G ++C + W
Sbjct: 228 PAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 286
Query: 460 TPPVPQCK--------VAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQG 511
P +P C V E T R Q +V SC GY L G+ C
Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ----EVFYSCEPGYDLRGAASMRCTP 342
Query: 512 TIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL---EDFPYGTTVTYTCNPGPERGVEFSL 568
W C+ +C + G + + G V + C+ G F L
Sbjct: 343 QGDWSPAAPTCEVKSCDD----FMGQLLNGRVLFPVNLQLGAKVDFVCDEG------FQL 392
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYF-YNDTVT 627
G S C E W+ P+C+ + C + + +GK F + TV
Sbjct: 393 KGSSASYCVLAGME-SLWNSSVPVCE----QIFCPSPPVIPNGRHTGKPLEVFPFGKTVN 447
Query: 628 FKCY------SGFTLKGSSQIRCKAD----NTWDPEIPVCE-KETCQ----------HVR 666
+ C + F L G S IRC +D W P C CQ +
Sbjct: 448 YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQ 507
Query: 667 QSLQELPAGSRVELVNTSCQDGYQLTGHAYQM-CQDAENGIWFKKIPLCKVIHCHPPPVI 725
+ + P G+ ++ C+ Y G + + C D N +W +CK C PP
Sbjct: 508 TNASDFPIGTSLKY---ECRPEYY--GRPFSITCLD--NLVWSSPKDVCKRKSCKTPPDP 560
Query: 726 VNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGHGSWSGPSPQCLRSPP 784
VNG + + G+ ++Y C G L+G +C S + H WS P C R P
Sbjct: 561 VNGMVH--VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH--WSTKPPICQRIP- 615
Query: 785 VTRCP-NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT-- 835
C P + +G ++ + + +V CNPG F + G I C +++
Sbjct: 616 ---CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 836 --WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLL 893
W P CI PP NG N + FS + + C G+++ G +
Sbjct: 673 GIWSGPAPQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 894 CTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS 953
C W P C V C P D+ ++ + + G V CE GY L G+
Sbjct: 730 CQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 788
Query: 954 QCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLIL 986
+C W+P C +S + + G +L
Sbjct: 789 RCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL 821
Score = 133 bits (335), Expect = 8e-31
Identities = 113/468 (24%), Positives = 179/468 (38%), Gaps = 86/468 (18%)
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
+FP GT + Y C PG G FS+I C N W+G C+ C +
Sbjct: 62 EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTGAKDRCRRK----SCRN 106
Query: 605 --------VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN---TWDPE 653
VH+ G + + + + C G+ L GSS C WD E
Sbjct: 107 PPDPVNGMVHVIKGIQ---------FGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
Query: 654 IPVCEKETC---------QHVRQSLQELPAGSRVELVNTSCQDG------YQLTGHAYQM 698
P+C++ C + + + GS +V C G ++L G
Sbjct: 158 TPICDRIPCGLPPTITNGDFISTNRENFHYGS---VVTYRCNPGSGGRKVFELVGEPSIY 214
Query: 699 C--QDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLG 756
C D + GIW P C + + PP + NG F V + C GF + G
Sbjct: 215 CTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG 274
Query: 757 EKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDC 816
++++C++ +K W P C R P P+V H + + +S V+ C
Sbjct: 275 PRRVKCQALNK----WEPELPSCSR----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 326
Query: 817 NPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA---FIGCPPPPKTPNGNHTGGNIARFSPG 873
PG+ + G+ +RC W P PTC K+ F+G + NG G
Sbjct: 327 EPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMG-----QLLNGRVLFP--VNLQLG 379
Query: 874 MSILYSCDQGYLLVGEALLLCT---HEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM 930
+ + CD+G+ L G + C E W+ P C+++ C SP + + +P ++
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 439
Query: 931 YQYGAVVTLECE------DGYMLEGSPQSQCQSDHQ----WNPPLAVC 968
+ +G V C+ + L G +C SD Q W+ P C
Sbjct: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
Score = 100 bits (249), Expect = 7e-21
Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 28/327 (8%)
Query: 671 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 730
E P G+ +N C+ GY +G + + +N +W C+ C PP VNG
Sbjct: 62 EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115
Query: 731 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP- 789
+ + +G+++ Y C +G+ L+G C S W +P C R P C
Sbjct: 116 H--VIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWDNETPICDRIP----CGL 168
Query: 790 NPEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPG 839
P + +G ++ + + +V CNPG F + G I C +++ W
Sbjct: 169 PPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 228
Query: 840 VPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT 899
P CI PP NG N + FS + + C G+++ G + C
Sbjct: 229 APQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
Query: 900 WSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH 959
W P C V C P D+ ++ + + G V CE GY L G+ +C
Sbjct: 286 WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
Query: 960 QWNPPLAVCRSRSLAPVLCGIAAGLIL 986
W+P C +S + + G +L
Sbjct: 345 DWSPAAPTCEVKSCDDFMGQLLNGRVL 371
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 372 bits (954), Expect = e-102
Identities = 290/1015 (28%), Positives = 428/1015 (42%), Gaps = 142/1015 (13%)
Query: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
ISCG PPP+ NG S + G+ + Y C+ + L+G+ + C +G+W+ +P
Sbjct: 1688 ISCGVPPPLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGSWNGVSP 1741
Query: 81 KC-------------------------------EYFNKYSSCPEPI---VPGGYKIRGST 106
C Y +C EPI PG + S+
Sbjct: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS 1801
Query: 107 P--YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEC--PALPMIHN 162
Y G VTF+C+ + + G + C + W +P C +V C PA+P N
Sbjct: 1802 GEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHL-IPYCKAV---SCGKPAIP--EN 1855
Query: 163 GHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFP 222
G E + + G VTY C GY L G+K +CL++ WS PP CE +C S
Sbjct: 1856 G--CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENIN 1912
Query: 223 NGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM-PVCEEIFCPSPPP 281
NGK + + TA++ CD GY LQGP C +G W + P C +FC PP
Sbjct: 1913 NGKYILSGLTYLS-TASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPA 1968
Query: 282 ILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341
I + GN N ++ + VTYTC +EG + L G T+ C D G WS +
Sbjct: 1969 IKDAVITGN---NFTFRNTVTYTC----KEG--YTLAGLDTIECLAD----GKWSRSDQQ 2015
Query: 342 CELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEP 401
C AV C P I+ S + + D + C G++L + Q+ CNAQG W P
Sbjct: 2016 C----LAVSCDEPPIV--DHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVP 2069
Query: 402 ----SAPVCEKE-CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSE 456
P C C+ PP++ E +F G+ + + C G+VL I+C
Sbjct: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
Query: 457 GVWTP-PVP-QCKVAACEATGRQL--LTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGT 512
G W P P+ QC C + + V SC +G+ + G C+ T
Sbjct: 2130 GQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEAT 2189
Query: 513 IPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
W I C ++C PP + NG HT + + + V Y CNPG + +G
Sbjct: 2190 GQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNPG------YKSVG 2239
Query: 571 ESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTFK 629
C +N W +PL + L C I NG+ K + V F
Sbjct: 2240 SPVFVCQANRH----WHSESPLMCVPL---DCGKPPPIQNGFM---KGENFEVGSKVQFF 2289
Query: 630 CYSGFTLKGSSQIRCKADNTWDPEI-PVCEKETCQH---VRQSLQELPAGSRVELVNTSC 685
C G+ L G S C+ W+ + P C C + L + V +V SC
Sbjct: 2290 CNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSC 2349
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
++G+ L G + C ++ W P+CK++ C PPP+I G A +F G+ V
Sbjct: 2350 KEGHVLQGPSVLKCLPSQQ--WNDSFPVCKIVLCTPPPLISFGVPIPSSALHF--GSTVK 2405
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSA 805
Y C GF+L G C+ D G+WS P P+C+ PV CP PE ++ A
Sbjct: 2406 YSCVGGFFLRGNSTTLCQPD----GTWSSPLPECV---PV-ECPQPEEIPNGIIDVQGLA 2457
Query: 806 YSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGG 865
Y + C PGF + G+ C + W+ G PTC KA I C P + NG +
Sbjct: 2458 YLSTAL--YTCKPGFELVGNTTTLCGENGHWLGGKPTC--KA-IECLKPKEILNGKFSYT 2512
Query: 866 NIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGL 925
++ G ++ YSC++G+ L G + L C G W AP C ++C SP I+ G
Sbjct: 2513 DL---HYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSP---QPIENGF 2566
Query: 926 EPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGI 980
Y YGA++ C G+ + G C+ + W+ + C P+ CG+
Sbjct: 2567 VEGADYSYGAIIIYSCFPGFQVAGHAMQTCE-ESGWSSSIPTC-----MPIDCGL 2615
Score = 370 bits (949), Expect = e-102
Identities = 296/1070 (27%), Positives = 422/1070 (39%), Gaps = 201/1070 (18%)
Query: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
+ CG PP I+NG S + + G ++ YSC+ F + GEK C + G W P P
Sbjct: 2144 VRCGEPPSIMNGYAS--GSNYSFGAMVAYSCNKGFYIKGEKKSTC----EATGQWSSPIP 2197
Query: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
C SC EP + +T V + C + G+ CQAN W
Sbjct: 2198 TCHPV----SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHS 2253
Query: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
CV PL+C P I NG EN G V + C GY LVG+ C S
Sbjct: 2254 ESPLMCV---PLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKS 2307
Query: 201 GKWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIA 259
GKW+ P C A+C N V + VGV F C EG+ LQGP +C+ +
Sbjct: 2308 GKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT-FSCKEGHVLQGPSVLKCLPS 2366
Query: 260 GQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318
Q W PVC+ + C PP I G I +S + +GS V Y+C F L
Sbjct: 2367 QQ---WNDSFPVCKIVLCTPPPLISFGVPIPSSALH--FGSTVKYSCVG------GFFLR 2415
Query: 319 GESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFA 378
G ST C D GTWS P P C V+CP P+ + ++ Q Y T ++
Sbjct: 2416 GNSTTLCQPD----GTWSSPLPECV----PVECPQPEEIPNGIIDVQG--LAYLSTALYT 2465
Query: 379 CMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKE--DRHMVRFDPGTSI 435
C GF L G+ C G W P C+ EC P ILNG+ D H G ++
Sbjct: 2466 CKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY-----GQTV 2520
Query: 436 KYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP-QHQFVRPDVNS- 493
YSCN G+ L G ++ C G W P C C++ +P ++ FV S
Sbjct: 2521 TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSP------QPIENGFVEGADYSY 2574
Query: 494 ------SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA---------- 537
SC G++++G Q C+ + W I C I C PP I G
Sbjct: 2575 GAIIIYSCFPGFQVAGHAMQTCEES-GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGY 2633
Query: 538 -------------------HTGSSLE--------------DFPYGTTVTYTCNPGPERGV 564
H G+ + +F YGT V+YTCNPG
Sbjct: 2634 FEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG----- 2688
Query: 565 EFSLIGESTIRCTSNDQERGTWSGPAPLCKL----------------------SLLAVQC 602
+ L+G + C QE GTW+G AP C S + C
Sbjct: 2689 -YELLGNPVLIC----QEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSC 2743
Query: 603 SHVHIANGYKI------------------------------SGKEAPYFYNDTVTFKCYS 632
HI G + S K + Y Y T+ ++C
Sbjct: 2744 KPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDP 2803
Query: 633 GFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVEL---VNTSCQDGY 689
G+ L G+ + C+ D WD + P+C C S G + +C +G+
Sbjct: 2804 GYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGF 2863
Query: 690 QLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD 749
L G ++C NG W P C + C PP + NG G+ ++ + EV++ C
Sbjct: 2864 LLEGARSRVC--LANGSWSGATPDCVPVRCATPPQLANGVTEGL---DYGFMKEVTFHCH 2918
Query: 750 QGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHN 809
+G+ L G KL C+SD G+W P C PV P ++ HG+ ++ H
Sbjct: 2919 EGYILHGAPKLTCQSD----GNWDAEIPLC---KPVNCGPPEDLAHGFP---NGFSFIHG 2968
Query: 810 DIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIAR 869
+ C PG+ ++G+ RC ++ +W P+C+ P TP + N
Sbjct: 2969 GHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL-------PCRCSTPVIEYGTVNGTD 3021
Query: 870 FSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRK 929
F G + C +G+ L+G + + C +G WS PHC+ +C S + I
Sbjct: 3022 FDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGS---LPMIPNAFISET 3078
Query: 930 MYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
V+T C GY+++GS C W+ P VC P+ CG
Sbjct: 3079 SSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCE-----PLSCG 3123
Score = 343 bits (881), Expect = 4e-94
Identities = 277/1085 (25%), Positives = 427/1085 (39%), Gaps = 205/1085 (18%)
Query: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
I C +P NG S VG + +SC ++L+G + C+ G W+ P
Sbjct: 1787 IKCKAPGNPENGHSS--GEIYTVGAEVTFSCQEGYQLMGVTKITCLE----SGEWNHLIP 1840
Query: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
C K SC +P +P I + G VT+ C +++ G+K C AN+ W
Sbjct: 1841 YC----KAVSCGKPAIPENGCIE-ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSH 1895
Query: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
+ P C P++C + I+NG + + ++ + +YSC++GY L G II C +S
Sbjct: 1896 SP-PVCE---PVKCSSPENINNGKYILSGLTYLS---TASYSCDTGYSLQGPSIIECTAS 1948
Query: 201 GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV----------TANFFCDEGYRLQG 250
G W PP C C EPP ++ V T + C EGY L G
Sbjct: 1949 GIWDRAPPACHLVFC-----------GEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAG 1997
Query: 251 PPSSRCVIAGQGVAWTKM-PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
+ C+ G+ W++ C + C PP + H A+ +G I Y C
Sbjct: 1998 LDTIECLADGK---WSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFYYCSD-- 2049
Query: 310 EEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH-PQILRGRMVSGQKDR 368
+ L S L C + PRC A C P + + S K +
Sbjct: 2050 ----GYSLADNSQLLCNAQGKWVPPEGQDMPRC----IAHFCEKPPSVSYSILESVSKAK 2101
Query: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE---KECQAPPNILNGQKEDRH 425
+ V F CM GF L S +I C G W PS + C PP+I+NG +
Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSN 2161
Query: 426 MVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC---EATGRQLLTKP 482
+ G + YSCN G+ + GE+ C + G W+ P+P C +C L
Sbjct: 2162 ---YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHT 2218
Query: 483 QHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRL-CKEITCPPPPVIYNGAHTGS 541
+ +V C GYK GS CQ W E L C + C PP I NG G
Sbjct: 2219 TGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG- 2277
Query: 542 SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA-PLC------- 593
E+F G+ V + CN G + L+G+S+ C Q+ G W+ + P C
Sbjct: 2278 --ENFEVGSKVQFFCNEG------YELVGDSSWTC----QKSGKWNKKSNPKCMPAKCPE 2325
Query: 594 ---------------KLSLLAVQCSHVHIANG---------------------------- 610
++ ++ C H+ G
Sbjct: 2326 PPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPP 2385
Query: 611 ---YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC---QH 664
+ + + + TV + C GF L+G+S C+ D TW +P C C +
Sbjct: 2386 LISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEE 2445
Query: 665 VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPV 724
+ + ++ + + +C+ G++L G+ +C ENG W P CK I C P
Sbjct: 2446 IPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLC--GENGHWLGGKPTCKAIECLKPKE 2503
Query: 725 IVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPP 784
I+NGK + + YG V+Y C++GF L G L C G W +P C
Sbjct: 2504 ILNGKFS---YTDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDWDVDAPSC----N 2552
Query: 785 VTRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTC 843
C +P+ +++G+ + YS+ I+ C PGF + G + C ++ W +PTC
Sbjct: 2553 AIHCDSPQPIENGF---VEGADYSYGAIIIYSCFPGFQVAGHAMQTCE-ESGWSSSIPTC 2608
Query: 844 IKKAFIGCPP--------------------------PPKTPNGNHTGGNIAR-------- 869
+ G PP P TP+ + G +A+
Sbjct: 2609 M-PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKES 2667
Query: 870 -------FSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP-ADMDGI 921
F G + Y+C+ GY L+G +L+C +GTW+ AP C + C P A +G
Sbjct: 2668 PATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGF 2727
Query: 922 QKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLA---PVLC 978
+ E G+ V C+ G++L GS C + +W+ C + S PV+
Sbjct: 2728 LRFTET----SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMN 2783
Query: 979 GIAAG 983
G G
Sbjct: 2784 GSIKG 2788
Score = 342 bits (877), Expect = 1e-93
Identities = 276/1010 (27%), Positives = 411/1010 (40%), Gaps = 155/1010 (15%)
Query: 28 PILNGRISYYSTP---IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEY 84
P L G + + T + G+ + C F+L+G C+ + G W +P P CE
Sbjct: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQ----GQWTQPLPHCER 1687
Query: 85 FNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLP 144
+ P P+ G + + G +VT+ C + + G+ ++C N W P
Sbjct: 1688 IS--CGVPPPLENG---FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS-P 1741
Query: 145 TCVSV--------------------------------------FPLECPALPMIHNGHHT 166
+C+ V P++C A NGH +
Sbjct: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS 1801
Query: 167 SENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV 226
E G VT+SC+ GY L+G I CL SG+W+ + P C+ C NG +
Sbjct: 1802 GE---IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCI 1858
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG 285
+E G + C++GY L G S C+ +W+ PVCE + C SP I NG
Sbjct: 1859 EE-LAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSPPVCEPVKCSSPENINNG 1914
Query: 286 RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345
++I L+ ++Y S +Y+CD + L G S + CT +G W P C L
Sbjct: 1915 KYI---LSGLTYLSTASYSCD------TGYSLQGPSIIECTA----SGIWDRAPPACHL- 1960
Query: 346 TSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPV 405
V C P ++ +++G + +T+ +TV + C G+TL G I C A G W S
Sbjct: 1961 ---VFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQ 2015
Query: 406 C-EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP-- 462
C C PP + + E H + G Y C+ GY L + C ++G W PP
Sbjct: 2016 CLAVSCDEPPIVDHASPETAHRLF---GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEG 2072
Query: 463 --VPQCKVAACE----ATGRQLLTKPQHQFVRPDVNS-SCGEGYKLSGSVYQECQGTIPW 515
+P+C CE + L + + +F V S C EG+ L+ S EC W
Sbjct: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW 2132
Query: 516 F---MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572
M I+ C + C PP I NG +GS ++ +G V Y+CN G F + GE
Sbjct: 2133 NPSPMSIQ-CIPVRCGEPPSIMNGYASGS---NYSFGAMVAYSCNKG------FYIKGEK 2182
Query: 573 TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGY--KISGKEAPYFYNDTVTFK 629
C + G WS P P C V C + NG+ +G+ + V ++
Sbjct: 2183 KSTC----EATGQWSSPIPTCH----PVSCGEPPKVENGFLEHTTGR----IFESEVRYQ 2230
Query: 630 CYSGFTLKGSSQIRCKADNTWDPEIP-VCEKETC------QHVRQSLQELPAGSRVELVN 682
C G+ GS C+A+ W E P +C C Q+ + GS+V+
Sbjct: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFF- 2289
Query: 683 TSCQDGYQLTGHAYQMCQDAENGIWFKKI-PLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741
C +GY+L G + CQ ++G W KK P C C PP++ N ++ E
Sbjct: 2290 --CNEGYELVGDSSWTCQ--KSGKWNKKSNPKCMPAKCPEPPLLENQL---VLKELTTEV 2342
Query: 742 NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC-PNPEVKHGYKLN 800
V++ C +G L G L+C + W+ P C + C P P + G +
Sbjct: 2343 GVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC----KIVLCTPPPLISFGVPI- 2393
Query: 801 KTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG 860
SA V C GF + G+ C D TW +P C+ + CP P + PNG
Sbjct: 2394 -PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP---VECPQPEEIPNG 2449
Query: 861 NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDG 920
+A S + LY+C G+ LVG LC G W P CK + C P +
Sbjct: 2450 IIDVQGLAYLS---TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKE--- 2503
Query: 921 IQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRS 970
I G YG VT C G+ LEG C W+ C +
Sbjct: 2504 ILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNA 2553
Score = 332 bits (850), Expect = 1e-90
Identities = 284/1028 (27%), Positives = 412/1028 (40%), Gaps = 168/1028 (16%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P I C P ILNG+ SY T + G + YSC+ FRL G +L C+ G W
Sbjct: 2491 PTCKAIECLKPKEILNGKFSY--TDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDW 2544
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
D AP C + P+PI G + Y +G + ++C F + G+ C+ +
Sbjct: 2545 DVDAPSCNAI--HCDSPQPIENGFVE---GADYSYGAIIIYSCFPGFQVAGHAMQTCEES 2599
Query: 136 NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKII 195
W + +PTC+ P++C P I G T + GY E+
Sbjct: 2600 G-WSSS-IPTCM---PIDCGLPPHIDFGDCTK-------------LKDDQGYF---EQED 2638
Query: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
+ + + PP A K+ G ++ C+ GY L G P
Sbjct: 2639 DMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI 2698
Query: 256 CVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W P C I C P NG S GS V Y+C P
Sbjct: 2699 CQEDG---TWNGSAPSCISIECDLPTAPENGFL---RFTETSMGSAVQYSCKP------G 2746
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
IL G S LR ++++K WSG +PRCE A+ C P + + G YTY T
Sbjct: 2747 HILAG-SDLRLCLENRK---WSGASPRCE----AISCKKPNPVMNGSIKGSN--YTYLST 2796
Query: 375 VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKECQAPPNILNGQKEDRHMVRFDPGT 433
+ + C G+ L G+++ C W+ P+C +C +PP NGQ VR D T
Sbjct: 2797 LYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQ------VRGDEYT 2850
Query: 434 ---SIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL---LTKPQHQFV 487
I+Y+CN G++L G S C + G W+ P C C AT QL +T+
Sbjct: 2851 FQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRC-ATPPQLANGVTEGLDYGF 2909
Query: 488 RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
+V C EGY L G+ CQ W EI LCK + C PP + +G G S F
Sbjct: 2910 MKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFS---FI 2966
Query: 548 YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCS---- 603
+G + Y C PG + L G S+ RC SN G+WSG +P C L +CS
Sbjct: 2967 HGGHIQYQCFPG------YKLHGNSSRRCLSN----GSWSGSSPSC----LPCRCSTPVI 3012
Query: 604 ----------------HVHIANGYKISG-------------------------------- 615
+ G+K+ G
Sbjct: 3013 EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPN 3072
Query: 616 ---KEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC---QHVRQSL 669
E + + +T+ C SG+ ++GSS + C W PVCE +C V ++
Sbjct: 3073 AFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAV 3132
Query: 670 QELPAGSRVELVNTSCQDGYQL-TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNG 728
A + V C +GY + T CQ ++G WF + C C P+ N
Sbjct: 3133 ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQ--KDGRWFPERISCSPKKC---PLPENI 3187
Query: 729 KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC 788
H + ++F +VS C +G+ G C+ D G+W P SP C
Sbjct: 3188 THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLD----GTWEPPFSDESCSP--VSC 3241
Query: 789 PNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA 847
PE +HG+ + S Y+ + C PG+ + G+R C + W GV C +
Sbjct: 3242 GKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETR 3298
Query: 848 FIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 907
C P + NG +I + G +++YSC++GY L G + CT GTWS P P C
Sbjct: 3299 ---CETPLEFLNGK---ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC 3352
Query: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 967
K C P + + L K + V+++C +G++L+G C D W A
Sbjct: 3353 KPNPCPVPFVIP--ENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAK 3410
Query: 968 CRSRSLAP 975
C S P
Sbjct: 3411 CEKISCGP 3418
Score = 309 bits (792), Expect = 8e-84
Identities = 252/948 (26%), Positives = 382/948 (40%), Gaps = 147/948 (15%)
Query: 89 SSCPEPIVPGGYKIRGSTPY--------RHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
S CP ++ GS P+ + G V C F + GN +C W
Sbjct: 1629 SDCP--------RLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ 1680
Query: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
LP C + C P + NG H++++ + G +VTY C +GY L+G+ + C +
Sbjct: 1681 P-LPHCERI---SCGVPPPLENGFHSADDFYA---GSTVTYQCNNGYYLLGDSRMFCTDN 1733
Query: 201 GKWSAVPPTC-----------------------------------------EEARCKSLG 219
G W+ V P+C E +CK+ G
Sbjct: 1734 GSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPG 1793
Query: 220 RFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM-PVCEEIFCPS 278
NG I VG F C EGY+L G C+ +G+ W + P C+ + C
Sbjct: 1794 NPENGH-SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE---WNHLIPYCKAVSCGK 1849
Query: 279 PPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGP 338
P NG LA ++GS VTY C+ + L G+ C +S +WS
Sbjct: 1850 PAIPENG--CIEELA-FTFGSKVTYRCNK------GYTLAGDKESSCLANS----SWSHS 1896
Query: 339 APRCELSTSAVQCPHPQ-ILRGR-MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQ 396
P CE V+C P+ I G+ ++SG TY T ++C G++L+G I C A
Sbjct: 1897 PPVCE----PVKCSSPENINNGKYILSG----LTYLSTASYSCDTGYSLQGPSIIECTAS 1948
Query: 397 GTWEPSAPVCEKE-CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTS 455
G W+ + P C C PP I + + F ++ Y+C GY L G ++I+C +
Sbjct: 1949 GIWDRAPPACHLVFCGEPPAIKDAVITGNN---FTFRNTVTYTCKEGYTLAGLDTIECLA 2005
Query: 456 EGVWTPPVPQCKVAACEATGRQLLTKPQ--HQFVRPDVNSSCGEGYKLSGSVYQECQGTI 513
+G W+ QC +C+ P+ H+ C +GY L+ + C
Sbjct: 2006 DGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
Query: 514 PWF----MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569
W ++ C C PP + S F G+ V++ C G F L
Sbjct: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEG------FVLN 2119
Query: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTF 628
+ I C G W+ P+P+ + + V+C I NGY SG Y + V +
Sbjct: 2120 TSAKIEC----MRGGQWN-PSPM-SIQCIPVRCGEPPSIMNGY-ASGSN--YSFGAMVAY 2170
Query: 629 KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC---QHVRQSLQELPAGSRVEL-VNTS 684
C GF +KG + C+A W IP C +C V E G E V
Sbjct: 2171 SCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQ 2230
Query: 685 CQDGYQLTGHAYQMCQDAENGIWFKKIPL-CKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743
C GY+ G +CQ N W + PL C + C PP I NG M ENF G++
Sbjct: 2231 CNPGYKSVGSPVFVCQ--ANRHWHSESPLMCVPLDCGKPPPIQNG---FMKGENFEVGSK 2285
Query: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS-PQCLRSPPVTRCPNPEVKHGYKLNKT 802
V + C++G+ L+G+ C+ G W+ S P+C+ + +CP P + + K
Sbjct: 2286 VQFFCNEGYELVGDSSWTCQKS----GKWNKKSNPKCMPA----KCPEPPLLENQLVLK- 2336
Query: 803 HSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNH 862
+ +V C G ++ G V++C W P C + C PPP G
Sbjct: 2337 -ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC---KIVLCTPPPLISFGVP 2392
Query: 863 TGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQ 922
+ F G ++ YSC G+ L G + LC +GTWS P P C V C P + I
Sbjct: 2393 IPSSALHF--GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEE---IP 2447
Query: 923 KGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRS 970
G+ + Y + C+ G+ L G+ + C + W C++
Sbjct: 2448 NGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKA 2495
Score = 307 bits (787), Expect = 3e-83
Identities = 271/1016 (26%), Positives = 393/1016 (38%), Gaps = 191/1016 (18%)
Query: 15 APGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGT 74
AP I C SP PI NG + + G +I YSC F++ G C +
Sbjct: 2548 APSCNAIHCDSPQPIENGFVE--GADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESG 2600
Query: 75 WDKPAPKCEYFN-------KYSSCPEPIVPGGY--------------------------- 100
W P C + + C + GY
Sbjct: 2601 WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKT 2660
Query: 101 -------KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLE 153
S+ + +G V++ C + + GN + CQ + W + P+C+S+ E
Sbjct: 2661 WENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA-PSCISI---E 2716
Query: 154 CPALPMIHNG--HHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCE 211
C NG T ++GS +V YSC+ G++L G + CL + KWS P CE
Sbjct: 2717 CDLPTAPENGFLRFTETSMGS-----AVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771
Query: 212 EARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPV 270
CK NG +K + T + CD GY L G C W + P+
Sbjct: 2772 AISCKKPNPVMNGSIKGSNYTYLS-TLYYECDPGYVLNGTERRTC---QDDKNWDEDEPI 2827
Query: 271 CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQ 330
C + C SPP NG+ G+ ++ + YTC+ EG F+L G + C +
Sbjct: 2828 CIPVDCSSPPVSANGQVRGD---EYTFQKEIEYTCN----EG--FLLEGARSRVCLAN-- 2876
Query: 331 KTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQ 390
G+WSG P C V+C P L + G Y + V F C G+ L G+ +
Sbjct: 2877 --GSWSGATPDC----VPVRCATPPQLANGVTEGLD--YGFMKEVTFHCHEGYILHGAPK 2928
Query: 391 IRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE 449
+ C + G W+ P+C+ C P ++ +G F G I+Y C PGY L G
Sbjct: 2929 LTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG---FSFIHGGHIQYQCFPGYKLHGNS 2985
Query: 450 SIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQE 508
S +C S G W+ P C C + T F C +G+KL G
Sbjct: 2986 SRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEIT 3045
Query: 509 CQGTIPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTTVTYTCNPGPERGVEF 566
C+ W C+ +C P+I N + T S E+ +TY+C G +
Sbjct: 3046 CEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKEN-----VITYSCRSG------Y 3094
Query: 567 SLIGESTIRCTSNDQERGTWSGPAPLCK----------LSLLAVQCSHVH-------IAN 609
+ G S + CT E+G WS P P+C+ + +A +H +
Sbjct: 3095 VIQGSSDLICT----EKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLE 3150
Query: 610 GYKI----------------------SGKEAP--------------YFYNDTVTFKCYSG 633
GY + S K+ P + N V+ C G
Sbjct: 3151 GYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEG 3210
Query: 634 FTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELP-----AGSRVELVNT---SC 685
+T +G + C+ D TW+P E+C V E P GS+ +T C
Sbjct: 3211 YTFEGVNISVCQLDGTWEPPF---SDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQC 3267
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
+ GY+L G+ ++CQ EN W + +CK C P +NGK EN G V
Sbjct: 3268 EPGYELEGNRERVCQ--ENRQWSGGVAICKETRCETPLEFLNGKAD---IENRTTGPNVV 3322
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSA 805
Y C++G+ L G + C +G+WS P P C +P CP P V L
Sbjct: 3323 YSCNRGYSLEGPSEAHCTE----NGTWSHPVPLCKPNP----CPVPFVIPENALLSEKEF 3374
Query: 806 YSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGG 865
Y + V + C GF++ G +I C+ D TW C K I C PP N G
Sbjct: 3375 YVDQN-VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEK---ISCGPPAHVENAIARG- 3429
Query: 866 NIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGI 921
+ G I YSC GY+L G +C GTW+ P P C+ V C P GI
Sbjct: 3430 --VHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PICRAV-CRFPCQNGGI 3481
Score = 80.9 bits (198), Expect = 6e-15
Identities = 66/237 (27%), Positives = 98/237 (41%), Gaps = 44/237 (18%)
Query: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIV 301
C EGYR G CE + CP+ P NG I N+ N + +
Sbjct: 362 CREGYRASGQ------------------TCELVHCPALKPPENGYFIQNTCNN-HFNAAC 402
Query: 302 TYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRM 361
C P F L+G S + C + G WSG C + T CPH + +
Sbjct: 403 GVRCHP------GFDLVGSSIILCLPN----GLWSGSESYCRVRT----CPHLRQPKHGH 448
Query: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKEC---QAPPN-I 416
+S Y T + AC G+ L+GS ++ C W+ P C E+ C Q P + I
Sbjct: 449 ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVI 508
Query: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVG-EESIQCTSEGVWTPPVPQCKVAACE 472
++ + +F GT SC G++L G +E ++CT+ G W V + A C+
Sbjct: 509 ISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV---QAAVCK 560
Score = 73.2 bits (178), Expect = 1e-12
Identities = 50/174 (28%), Positives = 72/174 (41%), Gaps = 15/174 (8%)
Query: 685 CQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEV 744
C G+ L G + +C NG+W C+V C +G H LY
Sbjct: 406 CHPGFDLVGSSIILC--LPNGLWSGSESYCRVRTCPHLRQPKHG-HISCSTREMLYKTTC 462
Query: 745 SYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL-RSPPVTRCPNPEVKHGYKLNKTH 803
CD+G+ L G KL C +G+ W GP P+C+ R + P + + K
Sbjct: 463 LVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP 518
Query: 804 SAYSHNDIVYVDCNPGFIMNG-SRVIRCHTDNTWVPGVPTCIKKAF----IGCP 852
+ + I YV C GFI++G ++RC T W GV + K I CP
Sbjct: 519 AKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCP 570
Score = 71.2 bits (173), Expect = 5e-12
Identities = 74/292 (25%), Positives = 108/292 (36%), Gaps = 60/292 (20%)
Query: 728 GKHTG---MMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDS-KGHGSWSGPSPQCL--- 780
G HTG + E YG + YEC C S + K GS G S C+
Sbjct: 297 GTHTGHFECICEKGYYGKGLQYECTA-----------CPSGTYKPEGSPGGIS-SCIPCP 344
Query: 781 ----RSPPVTRCPNPEV-KHGYKLNKTHSAYSH---------------------NDIVYV 814
SPP + P V + GY+ + H N V
Sbjct: 345 DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
Query: 815 DCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGM 874
C+PGF + GS +I C + W C + P + P H +
Sbjct: 405 RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTC----PHLRQPKHGHISCSTREMLYKT 460
Query: 875 SILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS---PAD--MDGIQKGLEPRK 929
+ L +CD+GY L G L C W P P C E +CS+ P D + G +P K
Sbjct: 461 TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK 520
Query: 930 MYQYGAVVTLECEDGYMLEGSPQS-QCQSDHQWNPPL--AVCRSRSLAPVLC 978
+G + + C G++L G + +C + +WN + AVC+ + C
Sbjct: 521 ---FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
Score = 70.9 bits (172), Expect = 6e-12
Identities = 71/287 (24%), Positives = 102/287 (35%), Gaps = 61/287 (21%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C +P LNG+ + G + YSC+ + L G C +GTW P P C
Sbjct: 3299 CETPLEFLNGKADIENR--TTGPNVVYSCNRGYSLEGPSEAHCTE----NGTWSHPVPLC 3352
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTR 142
K + CP P V + + +V+ C+ F + G+ + C + W
Sbjct: 3353 ----KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETW---- 3404
Query: 143 LPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK 202
T + C P H + + V G +TYSC SGY+L G CL +G
Sbjct: 3405 TQTSAKCEKISCG--PPAHVENAIARGV-HYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461
Query: 203 WSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQG 262
W++ P C+++ RFP C G Q P + C G
Sbjct: 3462 WTSPP------ICRAVCRFP-------------------CQNGGICQRPNACSCPEGWMG 3496
Query: 263 VAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
+CEE C P LNG + Y CD P
Sbjct: 3497 ------RLCEEPICIL--PCLNGGR-----------CVAPYQCDCPP 3524
Score = 68.9 bits (167), Expect = 2e-11
Identities = 77/258 (29%), Positives = 98/258 (37%), Gaps = 31/258 (12%)
Query: 536 GAHTGSS---LEDFPYGTTVTYTCNPGPERGV--EFSLIG-ESTIRCTSNDQER--GTWS 587
G HTG E YG + Y C P E S G S I C + G+ S
Sbjct: 297 GTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTS 356
Query: 588 GPAPLCKLSLLAV--QCSHVHIA------NGYKISGKEAPYFYNDTVTFKCYSGFTLKGS 639
+C+ A C VH NGY I +F N +C+ GF L GS
Sbjct: 357 PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGS 415
Query: 640 SQIRCKADNTWDPEIPVCEKETCQHVRQSLQ-ELPAGSRVELVNT----SCQDGYQLTGH 694
S I C + W C TC H+RQ + +R L T +C +GY+L G
Sbjct: 416 SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGS 475
Query: 695 AYQMCQDAENGIWFKKIPLCKVIHCH----PPPVIVNGKHTGMMAENFLYGNEVSYECDQ 750
CQ N W P C HC P VI++ + G F G C Q
Sbjct: 476 DKLTCQG--NSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQ 531
Query: 751 GFYLLGEKK-LQCRSDSK 767
GF L G K+ L+C + K
Sbjct: 532 GFILSGVKEMLRCTTSGK 549
Score = 57.8 bits (138), Expect = 5e-08
Identities = 49/172 (28%), Positives = 70/172 (40%), Gaps = 33/172 (19%)
Query: 439 CNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNS----- 493
C+PG+ LVG I C G+W+ C+V C L +P+H +
Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPH-----LRQPKHGHISCSTREMLYKT 460
Query: 494 ----SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCP----PPPVIYNGAHTGSSLED 545
+C EGY+L GS CQG W C E C P VI + + G +
Sbjct: 461 TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QP 518
Query: 546 FPYGTTVTYTCNPGPERGVEFSLIG-ESTIRCTSNDQERGTWS--GPAPLCK 594
+GT +C G F L G + +RCT++ G W+ A +CK
Sbjct: 519 AKFGTICYVSCRQG------FILSGVKEMLRCTTS----GKWNVGVQAAVCK 560
Score = 57.0 bits (136), Expect = 9e-08
Identities = 57/194 (29%), Positives = 80/194 (41%), Gaps = 27/194 (13%)
Query: 152 LECPALPMIHNGH---HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPP 208
+ CPAL NG+ +T N + A G+ C G+ LVG II CL +G WS
Sbjct: 376 VHCPALKPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSGSES 431
Query: 209 TCEEARCKSLGRFPNGKVK-EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK 267
C C L + +G + + T CDEGYRL+G S + G
Sbjct: 432 YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEG--SDKLTCQGNSQWDGP 489
Query: 268 MPVCEEIFCPS----PPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIG-EST 322
P C E C + I++ + G A +G+I +C FIL G +
Sbjct: 490 EPRCVERHCSTFQMPKDVIISPHNCGKQPA--KFGTICYVSCRQ------GFILSGVKEM 541
Query: 323 LRCTVDSQKTGTWS 336
LRCT +G W+
Sbjct: 542 LRCTT----SGKWN 551
Score = 55.5 bits (132), Expect = 3e-07
Identities = 45/195 (23%), Positives = 74/195 (37%), Gaps = 15/195 (7%)
Query: 91 CPEPIVP-GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149
CP P GY I+ + + C F + G+ + C N +W + V
Sbjct: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT 437
Query: 150 FPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT 209
CP L +G H S + + + +C+ GY L G + C + +W P
Sbjct: 438 ----CPHLRQPKHG-HISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPR 492
Query: 210 CEEARC------KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS-RCVIAGQG 262
C E C K + P+ K+P + G C +G+ L G RC +G+
Sbjct: 493 CVERHCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
Query: 263 VAWTKMPVCEEIFCP 277
+ VC+++ P
Sbjct: 551 NVGVQAAVCKDVEAP 565
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/161 (27%), Positives = 66/161 (40%), Gaps = 22/161 (13%)
Query: 51 CSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGST-PYR 109
C F L+G +LC+ +G W C + +CP P I ST
Sbjct: 406 CHPGFDLVGSSIILCLP----NGLWSGSESYC----RVRTCPHLRQPKHGHISCSTREML 457
Query: 110 HGDSVTFACKTNFSMNGNKSVWCQANNMW-GPTRLPTCV----SVFPLECPALPMIHNGH 164
+ + AC + + G+ + CQ N+ W GP P CV S F + + HN
Sbjct: 458 YKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPE--PRCVERHCSTFQMPKDVIISPHNCG 515
Query: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEK-IINCLSSGKWS 204
G+I SC G++L G K ++ C +SGKW+
Sbjct: 516 KQPAKFGTIC-----YVSCRQGFILSGVKEMLRCTTSGKWN 551
Score = 36.6 bits (83), Expect = 0.13
Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 7/110 (6%)
Query: 31 NGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-EYFNKYS 89
+G IS + + T +C +RL G L C + + WD P P+C E
Sbjct: 446 HGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTF 501
Query: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW-CQANNMW 138
P+ ++ + G P + G +C+ F ++G K + C + W
Sbjct: 502 QMPKDVIISPHNC-GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 345 bits (885), Expect = 1e-94
Identities = 284/979 (29%), Positives = 415/979 (42%), Gaps = 106/979 (10%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C +P +G I T + +V+R++C FRL+G+ S +C WD P P C
Sbjct: 2529 CSTPESPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK--SVWCQANNMW-G 139
+ SC P P I +T Y G VT+ C + ++ + + CQ++ W
Sbjct: 2588 QAI----SCGIPKAPTNGGIL-TTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSN 2642
Query: 140 PTRLPTCVSVFPLECPALP--MIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINC 197
+ P CV V CP++ ++ +G N V +SC+ GY +G I C
Sbjct: 2643 HNKTPRCVVV---TCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC 2699
Query: 198 LSSGKWS--AVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
L +G WS P C+ C L PNG K G TA F CD G+ L G
Sbjct: 2700 LPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRE 2758
Query: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+ +G W++ C C P I+NG+ IG N Y V Y C+P
Sbjct: 2759 CLSSG---LWSESETRCLAGHCGIPELIVNGQVIGE---NYGYRDTVVYQCNP------G 2806
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK--DRYTYN 372
F LIG S C Q+ WSG P C V C HP G + G+ + + +N
Sbjct: 2807 FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFNFN 2854
Query: 373 DTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDR-HMVRFD 430
D V F+C G+ ++G + +C A W P+C+ C P N ++E + F
Sbjct: 2855 DVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFT 2914
Query: 431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLLTKPQHQFV 487
GT + Y CNPGY L G + C G W P+P+C + C G +L+ ++ F
Sbjct: 2915 YGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTF- 2973
Query: 488 RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCK---EITCPPPPVIYNGAHTGSSLE 544
V+ SC L G + CQ W C TC P +G+ S
Sbjct: 2974 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQES--- 3030
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
+F +TV Y C+ G + L G C +N G+W+G P CK AVQC +
Sbjct: 3031 NFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECK----AVQCGN 3076
Query: 605 V-HIANG--YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKET 661
ANG ++I G ++ +V + C G+ L G S +C A+ TW +P C +
Sbjct: 3077 PGTTANGKVFRIDGTT----FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3132
Query: 662 CQHVRQSLQELPAGSRV---ELVNTSCQDGY--QLTGHAYQMCQDAENGIWFKKIPLCKV 716
C L G + V+ CQ GY +L G + C NG W +P C+
Sbjct: 3133 CGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTC--TINGTWSGVMPTCRA 3190
Query: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776
+ C PP I NG+ G NF +G +SY C G+ L L C G+G+WSG
Sbjct: 3191 VTCPTPPQISNGRLEG---TNFDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEV 3243
Query: 777 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 836
PQCL C +P + K + ++ + V CN FI+ GS C D TW
Sbjct: 3244 PQCLPK----FCGDPGIPAQGK--REGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTW 3297
Query: 837 VPGVPTCIKKAFIGCPPP--PKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC 894
P CI+ C P P+ + N+T G F G + + C +G+LL G C
Sbjct: 3298 SGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKGHLLQGSTTRTC 3353
Query: 895 THEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954
+ TWS P C +C P + + +G + C+ G+ L G + +
Sbjct: 3354 LPDLTWSGIQPECIPHSCKQPE--TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR 3411
Query: 955 -CQSDHQWNPPLAVCRSRS 972
C+SD+ W + +C + S
Sbjct: 3412 VCRSDNTWTGKVPICEAGS 3430
Score = 312 bits (800), Expect = 9e-85
Identities = 258/925 (27%), Positives = 389/925 (42%), Gaps = 114/925 (12%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P ISCG P NG I +T VGT + Y C+ +RL ++ + + DGTW
Sbjct: 2585 PACQAISCGIPKAPTNGGI--LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQS--DGTW 2640
Query: 76 DK--PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
P+C S + G ++I + Y + V F+C + G S+ C
Sbjct: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL 2700
Query: 134 ANNMWG-PTRLPTCVSVFPLECPALPMIHNGHH--TSENVGSIAPGLSVTYSCESGYLLV 190
N W P C + C LP NG+ T + GS A ++C+ G++LV
Sbjct: 2701 PNGTWSWRNERPYCQII---SCGELPTPPNGNKIGTQTSYGSTA-----IFTCDLGFMLV 2752
Query: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV------TANFFCDE 244
G + CLSSG WS C C NG+V +G T + C+
Sbjct: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV-------IGENYGYRDTVVYQCNP 2805
Query: 245 GYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTY 303
G+RL G S I Q W+ ++P C + C P + GR GN ++ +VT+
Sbjct: 2806 GFRLIG---SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGF---NFNDVVTF 2859
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRG--RM 361
+C+ + +++ G + +C + Q WS P P C++ V C P I R
Sbjct: 2860 SCN------IGYLMQGPTKAQCQANRQ----WSHPPPMCKV----VNCSDPGIPANSKRE 2905
Query: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-EC---QAPPN-I 416
+ +TY V + C G+ L GS + C G W+ P C +C PPN +
Sbjct: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAV 2965
Query: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGR 476
L+G+K + G+++ YSC L+G+ S C G W+ P C A G
Sbjct: 2966 LSGEK-------YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 3018
Query: 477 QLL----TKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP 531
++ + F + V +C GY L GS + C W CK + C P
Sbjct: 3019 PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG 3078
Query: 532 VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591
NG ++ + ++V Y+C G + L G S +CT+N GTWSG P
Sbjct: 3079 TTANG--KVFRIDGTTFSSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLP 3126
Query: 592 LCKLSLLAVQCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYSGFT--LKGSSQIRCKADN 648
C + + C I ANG + Y V++ C G+T L GS C +
Sbjct: 3127 NCTI----ISCGDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3179
Query: 649 TWDPEIPVCEKETCQHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENG 705
TW +P C TC Q G+ + ++ C GY+L+ A C NG
Sbjct: 3180 TWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTC--VGNG 3237
Query: 706 IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSD 765
W ++P C C P + GK G ++F+Y +EVS+ C+ F L+G C++D
Sbjct: 3238 TWSGEVPQCLPKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQAD 3294
Query: 766 SKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824
G+WSG SP C+ P T C NP V +HG + N + +V C G ++ G
Sbjct: 3295 ----GTWSGSSPHCI-EPTQTSCENPGVPRHGSQNNT--FGFQVGSVVQFHCKKGHLLQG 3347
Query: 825 SRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGY 884
S C D TW P CI + C P + N G ++ S G +++Y+C G+
Sbjct: 3348 STTRTCLPDLTWSGIQPECIPHS---CKQPETPAHANVVGMDLP--SHGYTLIYTCQPGF 3402
Query: 885 LLV-GEALLLCTHEGTWSQPAPHCK 908
L G +C + TW+ P C+
Sbjct: 3403 FLAGGTEHRVCRSDNTWTGKVPICE 3427
Score = 306 bits (784), Expect = 7e-83
Identities = 257/913 (28%), Positives = 380/913 (41%), Gaps = 94/913 (10%)
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
+K + Y Y S PE P GY I T + V +AC F + G S C+ +
Sbjct: 2516 NKKGFRIRYIAFYCSTPES-PPHGYII-SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2573
Query: 136 NM----WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
+ W +P C ++ P P + G T++ + G VTY C GY L
Sbjct: 2574 SYGYHAWDAP-VPACQAI-SCGIPKAPT-NGGILTTDYL----VGTRVTYFCNDGYRLSS 2626
Query: 192 EKIIN--CLSSGKWSA--VPPTCEEARCKSLGRF----PNGKVKEPPILRVGVTANFFCD 243
+++ C S G WS P C C S+ F ++ F CD
Sbjct: 2627 KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCD 2686
Query: 244 EGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTY 303
GY GP S C+ G + P C+ I C P NG IG SYGS +
Sbjct: 2687 PGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQ---TSYGSTAIF 2743
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVS 363
TCD + F+L+G + C +G WS RC A C P+++ V
Sbjct: 2744 TCD------LGFMLVGSAVRECL----SSGLWSESETRC----LAGHCGIPELIVNGQVI 2789
Query: 364 GQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKE 422
G+ Y Y DTV++ C GF L GS C W P C C P + + G+
Sbjct: 2790 GEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTS 2847
Query: 423 DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP 482
F+ + +SCN GY++ G QC + W+ P P CKV C G +K
Sbjct: 2848 GNG---FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKR 2904
Query: 483 QHQFVRPD------VNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
+ + + V C GY L GS CQ W + C I C P V N
Sbjct: 2905 ESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA 2964
Query: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
+G E + +G+TV Y+C + SL+G+S+ C N G WSG P C
Sbjct: 2965 VLSG---EKYTFGSTVHYSCTG------KRSLLGQSSRTCQLN----GHWSGSQPHCSGD 3011
Query: 597 LLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPV 656
+G S +E+ + TV + C +G+ L GS + C A+ +W P
Sbjct: 3012 ATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPE 3068
Query: 657 CEKETCQH----VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
C+ C + + + + V SC +GY L+G + + C NG W +P
Sbjct: 3069 CKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC--TANGTWSGTLP 3126
Query: 713 LCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFY--LLGEKKLQCRSDSKGHG 770
C +I C P + NG G ++++ G VSY C G+ L G + C + G
Sbjct: 3127 NCTIISCGDPGIPANGLRYG---DDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN----G 3179
Query: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
+WSG P C CP P +L T+ + + I Y+ C+PG+ ++ V+ C
Sbjct: 3180 TWSGVMPTCR----AVTCPTPPQISNGRLEGTNFDWGFS-ISYI-CSPGYELSFPAVLTC 3233
Query: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
+ TW VP C+ K F G P P G G + S + +SC+ ++LVG +
Sbjct: 3234 VGNGTWSGEVPQCLPK-FCGDPGIPA--QGKREGKSFIYQS---EVSFSCNFPFILVGSS 3287
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM-YQYGAVVTLECEDGYMLEG 949
+C +GTWS +PHC E +S + + G + +Q G+VV C+ G++L+G
Sbjct: 3288 TRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG 3347
Query: 950 SPQSQCQSDHQWN 962
S C D W+
Sbjct: 3348 STTRTCLPDLTWS 3360
Score = 249 bits (635), Expect = 1e-65
Identities = 245/905 (27%), Positives = 368/905 (40%), Gaps = 157/905 (17%)
Query: 154 CPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCE 211
C P + N +E+ G + Y C G+ LVG I+ C + PP C+
Sbjct: 2355 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413
Query: 212 ------EARCKSLG---------RFPNGKV-----------------------KEPPILR 233
E R S G +PN ++ KE +L+
Sbjct: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQ 2473
Query: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQG----VAWTKMPVCEE---------IFCPSPP 280
V N L G SS I G + W+ + +C +P
Sbjct: 2474 VYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPE 2533
Query: 281 PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAP 340
+G I + ++ S+V + CD F L+G+S+ C S W P P
Sbjct: 2534 SPPHGYIISQTGGQLN--SVVRWACDR------GFRLVGKSSAVCRKSSYGYHAWDAPVP 2585
Query: 341 RCELSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR---CNAQ 396
C+ A+ C P+ G +++ Y V + C G+ L SK++ C +
Sbjct: 2586 ACQ----AISCGIPKAPTNGGILTTD---YLVGTRVTYFCNDGYRLS-SKELTTAVCQSD 2637
Query: 397 GTWEP--SAPVCEK-ECQAPPNIL--NGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESI 451
GTW P C C + + + +G+ + ++ T + +SC+PGY +G SI
Sbjct: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2697
Query: 452 QCTSEGVWT--PPVPQCKVAACEATGRQLLTKPQHQFVRPDVNS------SCGEGYKLSG 503
+C G W+ P C++ +C +L T P + + +C G+ L G
Sbjct: 2698 ECLPNGTWSWRNERPYCQIISCG----ELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2753
Query: 504 SVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERG 563
S +EC + W C C P +I NG G E++ Y TV Y CNPG
Sbjct: 2754 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG---- 2806
Query: 564 VEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP--YF 621
F LIG S C Q+ WSG P C + V C H G I G+ + +
Sbjct: 2807 --FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFN 2852
Query: 622 YNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE-- 679
+ND VTF C G+ ++G ++ +C+A+ W P+C+ C S +PA S+ E
Sbjct: 2853 FNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC-----SDPGIPANSKRESK 2907
Query: 680 ----------LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGK 729
+V C GY L G + +CQ NG W K +P C +I C P V N
Sbjct: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP--NGQWDKPLPECIMIDCGHPGVPPNAV 2965
Query: 730 HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP 789
+G E + +G+ V Y C LLG+ C+ + G WSG P C T C
Sbjct: 2966 LSG---EKYTFGSTVHYSCTGKRSLLGQSSRTCQLN----GHWSGSQPHCSGDATGT-CG 3017
Query: 790 NPEVK-HGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAF 848
+P HG ++ S + V C+ G+I++GS C + +W P C KA
Sbjct: 3018 DPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA- 3071
Query: 849 IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908
+ C P T NG + FS S++YSC +GY+L G ++ CT GTWS P+C
Sbjct: 3072 VQCGNPGTTANGKVFRIDGTTFSS--SVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129
Query: 909 EVNCSSPADMDGI-QKGLEPRKMYQYGAVVTLECEDGYMLE--GSPQSQCQSDHQWNPPL 965
++C P GI GL Y G V+ C+ GY +E GS C + W+ +
Sbjct: 3130 IISCGDP----GIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3185
Query: 966 AVCRS 970
CR+
Sbjct: 3186 PTCRA 3190
Score = 196 bits (499), Expect = 7e-50
Identities = 152/579 (26%), Positives = 240/579 (41%), Gaps = 89/579 (15%)
Query: 435 IKYSCNPGYVLVGEESIQCTSEG----VWTPPVPQCKVAAC----EATGRQLLTKPQHQF 486
++++C+ G+ LVG+ S C W PVP C+ +C T +LT
Sbjct: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDY--L 2609
Query: 487 VRPDVNSSCGEGYKLSGSVYQE--CQGTIPWFMEIRL--CKEITCPPPPV---------I 533
V V C +GY+LS CQ W + C +TCP I
Sbjct: 2610 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2669
Query: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS--GPAP 591
NG+H + Y T V ++C+PG + +G ++I C N GTWS P
Sbjct: 2670 VNGSH-------YEYKTKVVFSCDPG------YHGLGPASIECLPN----GTWSWRNERP 2712
Query: 592 LCKLSLLAVQCSHVHIA-NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTW 650
C++ + C + NG KI + + Y T F C GF L GS+ C + W
Sbjct: 2713 YCQI----ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLGFMLVGSAVRECLSSGLW 2765
Query: 651 DPEIPVCEKETCQHVRQSLQELPAGSRV--------ELVNTSCQDGYQLTGHAYQMCQDA 702
C C + EL +V + V C G++L G + ++CQ
Sbjct: 2766 SESETRCLAGHC-----GIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD 2820
Query: 703 ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762
N W ++P C + C P + G+ +G F + + V++ C+ G+ + G K QC
Sbjct: 2821 HN--WSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQC 2875
Query: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT--HSAYSHNDIVYVDCNPGF 820
+++ + WS P P C V C +P + K H +++ +V+ DCNPG+
Sbjct: 2876 QANRQ----WSHPPPMC----KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGY 2927
Query: 821 IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSC 880
+ GS V+ C + W +P CI I C P PN +G +++ G ++ YSC
Sbjct: 2928 FLFGSSVLICQPNGQWDKPLPECI---MIDCGHPGVPPNAVLSG---EKYTFGSTVHYSC 2981
Query: 881 DQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLE 940
L+G++ C G WS PHC + D G ++ + V
Sbjct: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYA 3041
Query: 941 CEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
C+ GY+L GS + C ++ W C++ V CG
Sbjct: 3042 CDTGYILHGSEERTCLANGSWTGRQPECKA-----VQCG 3075
Score = 117 bits (294), Expect = 4e-26
Identities = 228/1044 (21%), Positives = 366/1044 (35%), Gaps = 181/1044 (17%)
Query: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69
F+ P C S P GR AVG+ + + C+ + L G ++ C T
Sbjct: 1825 FVYQAVPRTSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1882
Query: 70 KVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS 129
W+ P C IVP G G R G ++ + N N
Sbjct: 1883 NSLAQWNDSLPTC------------IVPCG----GILTKRKGTILSPGYPEPYDNNLN-C 1925
Query: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTY---SCESG 186
VW ++ +L G + + +GS + G ++ + S +
Sbjct: 1926 VWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYS-GTTIPHLLNSTSNN 1984
Query: 187 YLLVGEKIINCLSSG---KWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFC 242
L + I+ ++G +++A+ +C E + S G +K VG +F C
Sbjct: 1985 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG------IKIGDRYMVGDVVSFQC 2038
Query: 243 DEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI- 300
D+GY LQG C+ G W +P+C C +G + S+
Sbjct: 2039 DQGYSLQGHSHITCM-PGPVRRWNYPIPICLAQ-CGGAMSDFSGVILSPGFPGNYPSSLD 2096
Query: 301 VTYTCDPDPEEGVNFILIGEST------LRCTVDSQKTGT----WSGPA-PRCELSTS-- 347
T+T + GV+ + ST L S +T T SGP P ST+
Sbjct: 2097 CTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHE 2156
Query: 348 ------------------------AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGF 383
CP P+ R V G +T T+ F C G+
Sbjct: 2157 TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND--FTVGQTISFECFPGY 2214
Query: 384 TLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441
TL G+ + C W P CE C +NG + PG +Y P
Sbjct: 2215 TLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNG-------TIYSPGYPDEY---P 2264
Query: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDVNS-SCG 496
+ + W VP T L T+P + F+ PD NS G
Sbjct: 2265 NF-----------QDCFWLVRVPPGNGIYINFT--VLQTEPIYDFITVWDGPDQNSPQIG 2311
Query: 497 E--GYKLSGSVYQECQGTIPWF----------------MEIRLCKEITCPPPPVIYNGAH 538
+ G SVY + F ++R+C+ PPPPV A
Sbjct: 2312 QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQ----PPPPV--PNAE 2365
Query: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL--- 595
+ ++F G + Y C PG F+L+G + + C ER G P+C++
Sbjct: 2366 ILTEDDEFEIGDIIRYQCLPG------FTLVGNAILTCRLG--ERLQMDGAPPVCQVLCP 2417
Query: 596 -SLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
+ L + + V ++ GY S + +S KG + + E
Sbjct: 2418 ANELRLDSTGVILSPGYPDS--------YPNLQMCAWSISVEKGYNITMFVEFFQTEKEF 2469
Query: 655 PVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
V + +++ + +G N + GH + A++G K +
Sbjct: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITS------NGHEVFLQWSADHGNNKKGFRIR 2523
Query: 715 KV-IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
+ +C P +G + V + CD+GF L+G+ CR S G+ +W
Sbjct: 2524 YIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581
Query: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR--CH 831
P P C C P+ + T Y V CN G+ ++ + C
Sbjct: 2582 APVPAC----QAISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQ 2635
Query: 832 TDNTWV--PGVPTCIKKAFIGCPPPPK--TPNGNHTGGNIARFSPGMSILYSCDQGYLLV 887
+D TW P C+ + CP +G N + + +++SCD GY +
Sbjct: 2636 SDGTWSNHNKTPRCV---VVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692
Query: 888 GEALLLCTHEGTWS--QPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVVTLECEDG 944
G A + C GTWS P+C+ ++C P +G + G + YG+ C+ G
Sbjct: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLG 2748
Query: 945 YMLEGSPQSQCQSDHQWNPPLAVC 968
+ML GS +C S W+ C
Sbjct: 2749 FMLVGSAVRECLSSGLWSESETRC 2772
Score = 99.0 bits (245), Expect = 2e-20
Identities = 78/276 (28%), Positives = 114/276 (41%), Gaps = 24/276 (8%)
Query: 14 VAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDG 73
V P ++C +PP I NGR+ T G I Y CS + L L C+ +G
Sbjct: 3184 VMPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVG----NG 3237
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
TW P+C K+ C +P +P K G + + + V+F+C F + G+ + CQ
Sbjct: 3238 TWSGEVPQC--LPKF--CGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILVGSSTRICQ 3292
Query: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
A+ W + P C+ C P +P H + N G V + C+ G+LL G
Sbjct: 3293 ADGTWSGSS-PHCIEPTQTSCENPGVPR----HGSQNNTFGFQVGSVVQFHCKKGHLLQG 3347
Query: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
CL WS + P C CK + V + G T + C G+ L G
Sbjct: 3348 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGG 3407
Query: 252 PSSRCVIAGQGVAWT-KMPVCE---EIFCPSPPPIL 283
R + WT K+P+CE +I P P L
Sbjct: 3408 TEHR--VCRSDNTWTGKVPICEAGSKILVKDPRPAL 3441
Score = 79.0 bits (193), Expect = 2e-14
Identities = 212/1013 (20%), Positives = 345/1013 (34%), Gaps = 220/1013 (21%)
Query: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149
SC +P +P + G + G +V+F+C + + ++ + + C+ N+ W LPTC ++
Sbjct: 969 SCLDPGIPVHGRRYGHD-FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP-LPTCDAL 1026
Query: 150 F---------PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCES-------GYLLVGEK 193
+ P P + + G V ++ + YLL+ E
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086
Query: 194 --IINCLSSGKWSAVPPTCE-------EARCKSLGRFPNG--------------KVKEPP 230
L+ S +PPT A+ + + F ++P
Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1146
Query: 231 ILR----------VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC--------- 271
I + +G T F C GYRL+G C+ G+ V +P C
Sbjct: 1147 IPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASAT 1206
Query: 272 -EEIFCPSPPPILN-----------------GRHIGNSLANVSYGSIVTYTCDPDPEEGV 313
E SP LN G +I +++ G ++ D +
Sbjct: 1207 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHL 1266
Query: 314 NFILIGESTLRCTVDSQKTGTW-------SGPAPRCELSTSAVQCPH------PQILRGR 360
G S T+ S W G +L ++ + H PQ G
Sbjct: 1267 LGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GY 1324
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILN 418
+S Q + T+I+ C G+TL GS ++C + W+ P C EC
Sbjct: 1325 KISDQG--HFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG------ 1376
Query: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL 478
RF G S +PGY + +++C +W V + + +
Sbjct: 1377 ---------RFK-GESSGRILSPGYPFPYDNNLRC----MWMIEVDPGNIVSLQFLAFD- 1421
Query: 479 LTKPQHQFVR----PDVNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLCKE---- 524
T+ H +R P N + ++SGS+ E TI + + + K
Sbjct: 1422 -TEASHDILRVWDGPPENDMLLK--EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAI 1478
Query: 525 -------ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCT 577
C P V NG G E G TV + C+PG + L GE I C
Sbjct: 1479 QFSSSVATACRDPGVPMNGTRNGDGREP---GDTVVFQCDPG------YELQGEERITCI 1529
Query: 578 SNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYN-----------DT 625
+ R W P+C +A ++ ++G+ +S PY ++ D
Sbjct: 1530 QVEN-RYFWQPSPPVC----IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADY 1584
Query: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSC 685
V + F+++ + D D P+ S Q+ R+E + +
Sbjct: 1585 VISLAFISFSIEPNYDFLYIYDGP-DSNSPLIG---------SFQDSKLPERIESSSNTM 1634
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
++ G E ++ C P I+NG GM ++ G+ V+
Sbjct: 1635 HLAFRSDGSVSYTGFHLEYKAKLRE-------SCFDPGNIMNGTRLGM---DYKLGSTVT 1684
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE---VKHGYKLNKT 802
Y CD G+ L G L C G W+ P C +P +R E + Y N
Sbjct: 1685 YYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKN-- 1741
Query: 803 HSAYSHNDIVYVDCNPGFIMNGSRVI--RCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG 860
+ HN + + F++ G V D V PT + +G
Sbjct: 1742 -YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLL-------SSLSG 1793
Query: 861 NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMD 919
+H+G ++ S G I + VG H Q P CSS P
Sbjct: 1794 SHSGESLP-LSSGNQITIR----FTSVGPITAKGFH--FVYQAVPRTSSTQCSSVPEPRF 1846
Query: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ----SDHQWNPPLAVC 968
G + G E + G+ V +C GY+L GS +C+ S QWN L C
Sbjct: 1847 GRRIGNE----FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895
Score = 68.6 bits (166), Expect = 3e-11
Identities = 170/817 (20%), Positives = 277/817 (33%), Gaps = 159/817 (19%)
Query: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-------------------- 82
+G + +SCS +RL G ++C+ + W P P+C
Sbjct: 1160 IGDTLTFSCSSGYRLEGTSEIICLGGGR--RVWSAPLPRCVAECGASATNNEGILLSPNY 1217
Query: 83 --EYFNKYSSCPEPIVPGGYKIRGSTPYRH---GDSV-----------TFACKTNFSMNG 126
Y N + V G I S H GD + T SM G
Sbjct: 1218 PLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277
Query: 127 ------NKSVWCQANNMW-----GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP 175
+ +W + N+ G + T + E P +P G+ S+ G A
Sbjct: 1278 LTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQ-GHFA- 1333
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233
G ++ Y C GY L G ++ C++ + W P+C A C GRF
Sbjct: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAECG--GRFK----------- 1379
Query: 234 VGVTANFFCDEGYRLQGPPSSRC----------VIAGQGVAWTKMPVCEEIFCPSPPPIL 283
G ++ GY + RC +++ Q +A+ + + PP
Sbjct: 1380 -GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP-- 1436
Query: 284 NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCE 343
+ L GS++ EG++ L + + D+ + SG A +
Sbjct: 1437 ----ENDMLLKEISGSLI--------PEGIHSTL---NIVTIQFDTDFYISKSGFAIQFS 1481
Query: 344 LSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWE 400
S+ A C P + +G D DTV+F C G+ L+G ++I C + W+
Sbjct: 1482 -SSVATACRDPGVPMNGTRNG--DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQ 1538
Query: 401 PSAPVCEKECQAPPNILNG---QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457
PS PVC C +G H + N YV+ S+ S
Sbjct: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI----SLAFISFS 1594
Query: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE---GYKLSGSVYQECQGTIP 514
+ P + + L+ Q + + SS ++ GSV
Sbjct: 1595 I-EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV-----SYTG 1648
Query: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
+ +E + +C P I NG G D+ G+TVTY C+ G + L G ST+
Sbjct: 1649 FHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYSTL 1699
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFK 629
C D R W+ P C H G + +G E Y N +V
Sbjct: 1700 TCIMGDDGRPGWNRALPSC------------HAPCGSRSTGSEGTVLSPNYPKNYSVGHN 1747
Query: 630 CYSGFTLKGSSQIRCK---ADNTWDPEIPVCEKETCQ-HVRQSLQELPAGSRVELVNTSC 685
C + + + + + V + T Q + SL +G + L
Sbjct: 1748 CVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPL----- 1802
Query: 686 QDGYQLTGHAYQMCQDAENGIWF--KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743
G Q+T + G F + +P C P G+ G F G+
Sbjct: 1803 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSS 1859
Query: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
V ++C+ G+ L G ++C + W+ P C+
Sbjct: 1860 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896
Score = 62.8 bits (151), Expect = 2e-09
Identities = 102/447 (22%), Positives = 162/447 (36%), Gaps = 79/447 (17%)
Query: 233 RVGVTANFFCDEGYRLQGPPSSRCVIAGQG-VAWTK-MPVCEEIFCPSPPPILNGRHIG- 289
++G T ++CD GY LQG + C++ G W + +P C C S G +
Sbjct: 1678 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLSP 1736
Query: 290 NSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
N N S G Y+ E F++ G+ T + GP + L +S
Sbjct: 1737 NYPKNYSVGHNCVYSIAVPKE----FVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1792
Query: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE 409
+ L + SG + T+ F + T KG + ++ +
Sbjct: 1793 GSHSGESLP--LSSGNQI------TIRFTSVGPITAKGFHFV-------YQAVPRTSSTQ 1837
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQ 465
C + P G++ F G+S+ + CNPGY+L G +I+C S W +P
Sbjct: 1838 CSSVPEPRFGRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894
Query: 466 CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525
C + C +LTK + + P Y E P+ + +I
Sbjct: 1895 C-IVPCGG----ILTKRKGTILSPG---------------YPE-----PYDNNLNCVWKI 1929
Query: 526 TCPP------PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579
T P V + H SL+ + G N P G + TSN
Sbjct: 1930 TVPEGAGIQVQVVSFATEHNWDSLDFYDGGD------NNAPRLGSYSGTTIPHLLNSTSN 1983
Query: 580 D---QERGTWSGPAPLCKLSLLAV---QCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYS 632
+ + S A L A+ C ++G KI + Y D V+F+C
Sbjct: 1984 NLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDR---YMVGDVVSFQCDQ 2040
Query: 633 GFTLKGSSQIRCKAD--NTWDPEIPVC 657
G++L+G S I C W+ IP+C
Sbjct: 2041 GYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Score = 59.7 bits (143), Expect = 1e-08
Identities = 142/694 (20%), Positives = 232/694 (33%), Gaps = 178/694 (25%)
Query: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335
CP P NG+ IG+ S GS V ++CD D ++L G ++ C ++ W
Sbjct: 446 CPDPGEPENGKRIGSDF---SLGSTVQFSCDED------YVLQGAKSITCQRIAEVFAAW 496
Query: 336 SGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNA 395
S P C++ T G + G +T + F F Q NA
Sbjct: 497 SDHRPVCKVKTC-----------GSNLQGPSGTFTSPN-------FPF------QYDSNA 532
Query: 396 QGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTS 455
Q W +A K Q +N ++ D + +G +++
Sbjct: 533 QCVWVITAVNTNKVIQ-----INFEEFD--------------------LEIGYDTLTIGD 567
Query: 456 EGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE-GYKLSGSVYQECQGTIP 514
G P +V +++ ++ + S G G+K++ Y+E +
Sbjct: 568 GGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN---YKEIE---- 620
Query: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
KE +C P G G + F + + C G F LIGE +I
Sbjct: 621 --------KE-SCGDPGTPLYGIREG---DGFSNRDVLRFECQFG------FELIGEKSI 662
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVT------- 627
C N+Q WS P+C C A + + P Y + +
Sbjct: 663 VCQENNQ----WSANIPIC-----IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIIS 713
Query: 628 ------FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELV 681
++ F L+ D PE P+ T V L S ++
Sbjct: 714 DPGSRIHLSFNDFDLESQFDFLAVKDGD-SPESPILGTFTGAEVPSHLT-----SNSHIL 767
Query: 682 NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741
Q + ++G + + + C P + +N + G +NF G
Sbjct: 768 RLEFQADHSMSGRGFNITYNTFGH-----------NECPDPGIPINARRFG---DNFQLG 813
Query: 742 NEVSYECDQGFY-LLGEKKLQCRSDSKGHGSWSGPSPQCLR------SPPVTRCPNP--- 791
+ +S C++GF G + + C G WSG P+C S P +P
Sbjct: 814 SSISVICEEGFIKTQGTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWP 872
Query: 792 -------------EVKHGYKLNKTHSAYS---HNDIVYVDCNPGFI------MNGSRV-- 827
E + G+ + T + + D++ V P + NG++V
Sbjct: 873 GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQ 932
Query: 828 ----------IRCHTDNTWV-PGVPTCIKKAFI---GCPPPPKTPNGNHTGGNIARFSPG 873
+ TDN+ G + + C P +G G + FS G
Sbjct: 933 FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIG 989
Query: 874 MSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 907
++ +SCD GY L E LLC WS P P C
Sbjct: 990 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 49.3 bits (116), Expect = 2e-05
Identities = 171/840 (20%), Positives = 278/840 (33%), Gaps = 172/840 (20%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG P L G + V+R+ C F LIGEKS++C + + W P
Sbjct: 623 SCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVC----QENNQWSANIPI 676
Query: 82 C------EYFNKYSSCPEPIVPGGYK---------IRGSTPYRHGDSVTFACKTNFSMNG 126
C + + P P GY I H F ++ F
Sbjct: 677 CIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLA 736
Query: 127 NKSVWCQANNMWG-------PTRLPTCVSVFPLECPA--------LPMIHN--GHHTSEN 169
K + + G P+ L + + LE A + +N GH+ +
Sbjct: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPD 796
Query: 170 VG----------SIAPGLSVTYSCESGYLLV-GEKIINC-LSSGK--WSAVPPTCEEARC 215
G + G S++ CE G++ G + I C L GK WS + P C A C
Sbjct: 797 PGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-GAPC 855
Query: 216 KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIF 275
P+G + P G+ S C + + + E F
Sbjct: 856 GGHFSAPSGVILSP---------------GWPGYYKDSLNCEWVIEAEPGHSIKITFERF 900
Query: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE---EGVNFILIGESTLRCTVDSQKT 332
+ H G +L + GS Y P+ NFI L T D+ ++
Sbjct: 901 QTELNYDVLEVHDGPNLLSPLLGS---YNGTQVPQFLFSSSNFIY-----LLFTTDNSRS 952
Query: 333 GTWSGPAPRCE-LSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQ 390
+G E ++ + C P I + GR ++ TV F+C G+ L +
Sbjct: 953 N--NGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEP 1007
Query: 391 IRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES 450
+ C W P C+ C VR GT + +PGY S
Sbjct: 1008 LLCEKNHWWSHPLPTCDALCGGD-------------VRGPSGTIL----SPGYPEFYPNS 1050
Query: 451 IQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY-KLSGS----- 504
+ CT WT V K + + H ++ N S + +L+GS
Sbjct: 1051 LNCT----WTVDVTHGK--GVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPT 1104
Query: 505 ----VYQECQGTIPWFMEIRLCKE---IT--------CPPPPVIYNGAHTGSSLEDFPYG 549
+Y + + + + + E IT C P + G+ G +F G
Sbjct: 1105 INAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGF---NFGIG 1161
Query: 550 TTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN 609
T+T++C+ G + L G S I C R WS P P C +C N
Sbjct: 1162 DTLTFSCSSG------YRLEGTSEIICLGGG--RRVWSAPLPRC-----VAECGASATNN 1208
Query: 610 GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE----KETCQHV 665
+ P Y + +C ++ I A + V + K+ H+
Sbjct: 1209 EGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHL 1266
Query: 666 -----RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 720
S++ L S + + T +Q+ + ++ HC
Sbjct: 1267 LGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS-----------FELSHCE 1315
Query: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
P + G + + G+ + Y C+ G+ L G L+C + + +W P P C+
Sbjct: 1316 DPGIPQFGYK--ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGER--RAWDYPLPSCI 1371
Score = 45.1 bits (105), Expect = 4e-04
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH----EGT 899
IK A CP P + NG G + FS G ++ +SCD+ Y+L G + C
Sbjct: 439 IKTASNLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 495
Query: 900 WSQPAPHCKEVNCSS 914
WS P CK C S
Sbjct: 496 WSDHRPVCKVKTCGS 510
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 34/252 (13%)
Query: 606 HIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT----WDPEIPVCEKET 661
+I NG ++ Y TVT+ C +G+ L+G S + C + W+ +P C
Sbjct: 1666 NIMNGTRLG---MDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC 1722
Query: 662 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGH--AYQMCQDAENGIWFKKIPLCKVIHC 719
GS +++ + Y + GH Y + E ++ + + +H
Sbjct: 1723 GSR--------STGSEGTVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLHD 1773
Query: 720 HPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--P 777
V + G ++ L + + L ++ R S G + G
Sbjct: 1774 ------VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827
Query: 778 QCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT- 835
Q + T+C + PE + G ++ + S V DCNPG+I++GS IRC T
Sbjct: 1828 QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSS---VLFDCNPGYILHGSIAIRCETVPNS 1884
Query: 836 ---WVPGVPTCI 844
W +PTCI
Sbjct: 1885 LAQWNDSLPTCI 1896
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQCKVA-ACEATGR 476
RFD G I+YSC GY+L G + C + V W PVP C+ AC T R
Sbjct: 153 RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMR 206
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG+P G + Y T VG IRYSC + L G L CI +WD P P
Sbjct: 137 SCGNPGVPPKGVL--YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194
Query: 82 C 82
C
Sbjct: 195 C 195
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/262 (20%), Positives = 91/262 (34%), Gaps = 42/262 (16%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C P NGK G +F G+ V + CD+ + L G K + C+ ++ +WS P
Sbjct: 446 CPDPGEPENGKRIG---SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502
Query: 779 C--------LRSPPVTRCPNPEVKHGYKLNK----THSAYSHNDIVYVDCNPGFIMNGSR 826
C L+ P T +P Y N +A + N ++ ++ + G
Sbjct: 503 CKVKTCGSNLQGPSGT-FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886
+ G P + + G P I S M + D+
Sbjct: 562 TLTIGDGGE--VGDPRTVLQVLTGSFVPDL----------IVSMSSQMWLHLQTDESVGS 609
Query: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946
VG + + KE+ S D G+ + V+ EC+ G+
Sbjct: 610 VGFKV--------------NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 655
Query: 947 LEGSPQSQCQSDHQWNPPLAVC 968
L G CQ ++QW+ + +C
Sbjct: 656 LIGEKSIVCQENNQWSANIPIC 677
Score = 38.9 bits (89), Expect = 0.025
Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 36/261 (13%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC P I+NG + +G+ + Y C + L G +L CI D W++ P
Sbjct: 1660 SCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717
Query: 82 CEYFNKYSSCPEPIVPGGYKIRG------STPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
C P G + G S Y SV C + ++ V+ Q
Sbjct: 1718 CH------------APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQF- 1764
Query: 136 NMWGPTRLPTCVSVF--PLECPALPMIHNGHHTSENVG-SIAPGLSVTYSCESGYLLVGE 192
++ T L V V+ P + +L +G H+ E++ S +++ ++ G
Sbjct: 1765 -VFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF 1823
Query: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPP 252
+ + AVP T +C S+ P + VG + F C+ GY L G
Sbjct: 1824 HFV-------YQAVPRT-SSTQCSSVPE-PRFGRRIGNEFAVGSSVLFDCNPGYILHGSI 1874
Query: 253 SSRCVIAGQGVA-WT-KMPVC 271
+ RC +A W +P C
Sbjct: 1875 AIRCETVPNSLAQWNDSLPTC 1895
Score = 37.7 bits (86), Expect = 0.056
Identities = 74/300 (24%), Positives = 108/300 (36%), Gaps = 61/300 (20%)
Query: 215 CKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCE 272
C G NGK + +G T F CDE Y LQG S C IA AW+ PVC+
Sbjct: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504
Query: 273 EIFCPSPPPILNGRHIGNSL-----ANVSYGSIVTYTCDPDPEEGVNF----ILIGESTL 323
C S +G + +N ++T + + +NF + IG TL
Sbjct: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDTL 563
Query: 324 RCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV-------SGQKDRYTYNDTVI 376
D + G PR L Q+L G V S Q + D +
Sbjct: 564 TIG-DGGEVGD-----PRTVL----------QVLTGSFVPDLIVSMSSQMWLHLQTDESV 607
Query: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436
+ F K ++ C GT P + E + +R ++RF+
Sbjct: 608 GSVGFKVNYKEIEKESCGDPGT--PLYGIREGD----------GFSNRDVLRFE------ 649
Query: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496
C G+ L+GE+SI C W+ +P C + C + T P + PD G
Sbjct: 650 --CQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSN----FTAPMGTVLSPDYPEGYG 702
Score = 35.8 bits (81), Expect = 0.21
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 7/62 (11%)
Query: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC----THEGTWSQPAPH 906
C P P G G RF G I YSC GY+L G L C + +W P P
Sbjct: 138 CGNPGVPPKGVLYG---TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194
Query: 907 CK 908
C+
Sbjct: 195 CR 196
Score = 35.8 bits (81), Expect = 0.21
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 6/49 (12%)
Query: 931 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
+ G+ V+ C+ GY L C+ +H W+ PL C LCG
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC------DALCG 1028
Score = 35.0 bits (79), Expect = 0.37
Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 9/81 (11%)
Query: 154 CPALPMIHNGHHTSENVGS-IAPGLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPP 208
CP NG + +GS + G +V +SC+ Y+L G K I C + WS P
Sbjct: 446 CPDPGEPENG----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501
Query: 209 TCEEARCKSLGRFPNGKVKEP 229
C+ C S + P+G P
Sbjct: 502 VCKVKTCGSNLQGPSGTFTSP 522
Score = 34.7 bits (78), Expect = 0.48
Identities = 15/42 (35%), Positives = 22/42 (52%)
Query: 738 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC 779
F G+++ Y C G+ L G +L C ++S SW P P C
Sbjct: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195
Score = 33.1 bits (74), Expect = 1.4
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH----QWNP 963
+E+ SS + KG+ + G + C GY+L+G PQ C ++ W+
Sbjct: 131 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 964 PLAVCRS 970
P+ +CR+
Sbjct: 191 PVPICRA 197
Score = 32.3 bits (72), Expect = 2.4
Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 89 SSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
SSC P VP + G T + GD + ++C T + ++G+ + C AN++
Sbjct: 136 SSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 183
Score = 32.3 bits (72), Expect = 2.4
Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 91 CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
CP+P P K GS + G +V F+C ++ + G KS+ CQ
Sbjct: 446 CPDPGEPENGKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQ 487
Score = 31.6 bits (70), Expect = 4.0
Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 14/73 (19%)
Query: 522 CKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQ 581
C PP V+Y F G + Y+C G + L G + C +N
Sbjct: 138 CGNPGVPPKGVLYGTR--------FDVGDKIRYSCVTG------YILDGHPQLTCIANSV 183
Query: 582 ERGTWSGPAPLCK 594
+W P P+C+
Sbjct: 184 NTASWDFPVPICR 196
Score = 31.2 bits (69), Expect = 5.3
Identities = 17/59 (28%), Positives = 26/59 (44%), Gaps = 5/59 (8%)
Query: 176 GLSVTYSCESGYLLVGEKIINCL----SSGKWSAVPPTCE-EARCKSLGRFPNGKVKEP 229
G + YSC +GY+L G + C+ ++ W P C E C R +G + P
Sbjct: 157 GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 215
Score = 31.2 bits (69), Expect = 5.3
Identities = 16/61 (26%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C P NG+ + ++G+ +++SC + L G KS+ C +V W P C
Sbjct: 446 CPDPGEPENGK--RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 83 E 83
+
Sbjct: 504 K 504
Score = 30.8 bits (68), Expect = 6.9
Identities = 15/64 (23%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 932 QYGAVVTLECEDGYMLEGSPQSQCQSD----HQWNPPLAVCRSRSLAPVLCGIAAGLILL 987
Q +VV C+ G+ L G + C+ H W+ P+ C++ S G++
Sbjct: 2547 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTT 2606
Query: 988 TFLI 991
+L+
Sbjct: 2607 DYLV 2610
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 345 bits (885), Expect = 1e-94
Identities = 284/979 (29%), Positives = 415/979 (42%), Gaps = 106/979 (10%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C +P +G I T + +V+R++C FRL+G+ S +C WD P P C
Sbjct: 2569 CSTPESPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK--SVWCQANNMW-G 139
+ SC P P I +T Y G VT+ C + ++ + + CQ++ W
Sbjct: 2628 QAI----SCGIPKAPTNGGIL-TTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSN 2682
Query: 140 PTRLPTCVSVFPLECPALP--MIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINC 197
+ P CV V CP++ ++ +G N V +SC+ GY +G I C
Sbjct: 2683 HNKTPRCVVV---TCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC 2739
Query: 198 LSSGKWS--AVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
L +G WS P C+ C L PNG K G TA F CD G+ L G
Sbjct: 2740 LPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRE 2798
Query: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+ +G W++ C C P I+NG+ IG N Y V Y C+P
Sbjct: 2799 CLSSG---LWSESETRCLAGHCGIPELIVNGQVIGE---NYGYRDTVVYQCNP------G 2846
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK--DRYTYN 372
F LIG S C Q+ WSG P C V C HP G + G+ + + +N
Sbjct: 2847 FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFNFN 2894
Query: 373 DTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDR-HMVRFD 430
D V F+C G+ ++G + +C A W P+C+ C P N ++E + F
Sbjct: 2895 DVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFT 2954
Query: 431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLLTKPQHQFV 487
GT + Y CNPGY L G + C G W P+P+C + C G +L+ ++ F
Sbjct: 2955 YGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTF- 3013
Query: 488 RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCK---EITCPPPPVIYNGAHTGSSLE 544
V+ SC L G + CQ W C TC P +G+ S
Sbjct: 3014 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQES--- 3070
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
+F +TV Y C+ G + L G C +N G+W+G P CK AVQC +
Sbjct: 3071 NFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECK----AVQCGN 3116
Query: 605 V-HIANG--YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKET 661
ANG ++I G ++ +V + C G+ L G S +C A+ TW +P C +
Sbjct: 3117 PGTTANGKVFRIDGTT----FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3172
Query: 662 CQHVRQSLQELPAGSRV---ELVNTSCQDGY--QLTGHAYQMCQDAENGIWFKKIPLCKV 716
C L G + V+ CQ GY +L G + C NG W +P C+
Sbjct: 3173 CGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTC--TINGTWSGVMPTCRA 3230
Query: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776
+ C PP I NG+ G NF +G +SY C G+ L L C G+G+WSG
Sbjct: 3231 VTCPTPPQISNGRLEG---TNFDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEV 3283
Query: 777 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 836
PQCL C +P + K + ++ + V CN FI+ GS C D TW
Sbjct: 3284 PQCLPK----FCGDPGIPAQGK--REGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTW 3337
Query: 837 VPGVPTCIKKAFIGCPPP--PKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC 894
P CI+ C P P+ + N+T G F G + + C +G+LL G C
Sbjct: 3338 SGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKGHLLQGSTTRTC 3393
Query: 895 THEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954
+ TWS P C +C P + + +G + C+ G+ L G + +
Sbjct: 3394 LPDLTWSGIQPECIPHSCKQPE--TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR 3451
Query: 955 -CQSDHQWNPPLAVCRSRS 972
C+SD+ W + +C + S
Sbjct: 3452 VCRSDNTWTGKVPICEAGS 3470
Score = 312 bits (800), Expect = 9e-85
Identities = 258/925 (27%), Positives = 389/925 (42%), Gaps = 114/925 (12%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P ISCG P NG I +T VGT + Y C+ +RL ++ + + DGTW
Sbjct: 2625 PACQAISCGIPKAPTNGGI--LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQS--DGTW 2680
Query: 76 DK--PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
P+C S + G ++I + Y + V F+C + G S+ C
Sbjct: 2681 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL 2740
Query: 134 ANNMWG-PTRLPTCVSVFPLECPALPMIHNGHH--TSENVGSIAPGLSVTYSCESGYLLV 190
N W P C + C LP NG+ T + GS A ++C+ G++LV
Sbjct: 2741 PNGTWSWRNERPYCQII---SCGELPTPPNGNKIGTQTSYGSTA-----IFTCDLGFMLV 2792
Query: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV------TANFFCDE 244
G + CLSSG WS C C NG+V +G T + C+
Sbjct: 2793 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV-------IGENYGYRDTVVYQCNP 2845
Query: 245 GYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTY 303
G+RL G S I Q W+ ++P C + C P + GR GN ++ +VT+
Sbjct: 2846 GFRLIG---SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGF---NFNDVVTF 2899
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRG--RM 361
+C+ + +++ G + +C + Q WS P P C++ V C P I R
Sbjct: 2900 SCN------IGYLMQGPTKAQCQANRQ----WSHPPPMCKV----VNCSDPGIPANSKRE 2945
Query: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-EC---QAPPN-I 416
+ +TY V + C G+ L GS + C G W+ P C +C PPN +
Sbjct: 2946 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAV 3005
Query: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGR 476
L+G+K + G+++ YSC L+G+ S C G W+ P C A G
Sbjct: 3006 LSGEK-------YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 3058
Query: 477 QLL----TKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP 531
++ + F + V +C GY L GS + C W CK + C P
Sbjct: 3059 PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG 3118
Query: 532 VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591
NG ++ + ++V Y+C G + L G S +CT+N GTWSG P
Sbjct: 3119 TTANG--KVFRIDGTTFSSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLP 3166
Query: 592 LCKLSLLAVQCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYSGFT--LKGSSQIRCKADN 648
C + + C I ANG + Y V++ C G+T L GS C +
Sbjct: 3167 NCTI----ISCGDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3219
Query: 649 TWDPEIPVCEKETCQHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENG 705
TW +P C TC Q G+ + ++ C GY+L+ A C NG
Sbjct: 3220 TWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTC--VGNG 3277
Query: 706 IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSD 765
W ++P C C P + GK G ++F+Y +EVS+ C+ F L+G C++D
Sbjct: 3278 TWSGEVPQCLPKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQAD 3334
Query: 766 SKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824
G+WSG SP C+ P T C NP V +HG + N + +V C G ++ G
Sbjct: 3335 ----GTWSGSSPHCI-EPTQTSCENPGVPRHGSQNNT--FGFQVGSVVQFHCKKGHLLQG 3387
Query: 825 SRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGY 884
S C D TW P CI + C P + N G ++ S G +++Y+C G+
Sbjct: 3388 STTRTCLPDLTWSGIQPECIPHS---CKQPETPAHANVVGMDLP--SHGYTLIYTCQPGF 3442
Query: 885 LLV-GEALLLCTHEGTWSQPAPHCK 908
L G +C + TW+ P C+
Sbjct: 3443 FLAGGTEHRVCRSDNTWTGKVPICE 3467
Score = 306 bits (784), Expect = 7e-83
Identities = 257/913 (28%), Positives = 380/913 (41%), Gaps = 94/913 (10%)
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
+K + Y Y S PE P GY I T + V +AC F + G S C+ +
Sbjct: 2556 NKKGFRIRYIAFYCSTPES-PPHGYII-SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2613
Query: 136 NM----WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
+ W +P C ++ P P + G T++ + G VTY C GY L
Sbjct: 2614 SYGYHAWDAP-VPACQAI-SCGIPKAPT-NGGILTTDYL----VGTRVTYFCNDGYRLSS 2666
Query: 192 EKIIN--CLSSGKWSA--VPPTCEEARCKSLGRF----PNGKVKEPPILRVGVTANFFCD 243
+++ C S G WS P C C S+ F ++ F CD
Sbjct: 2667 KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCD 2726
Query: 244 EGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTY 303
GY GP S C+ G + P C+ I C P NG IG SYGS +
Sbjct: 2727 PGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQ---TSYGSTAIF 2783
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVS 363
TCD + F+L+G + C +G WS RC A C P+++ V
Sbjct: 2784 TCD------LGFMLVGSAVRECL----SSGLWSESETRC----LAGHCGIPELIVNGQVI 2829
Query: 364 GQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKE 422
G+ Y Y DTV++ C GF L GS C W P C C P + + G+
Sbjct: 2830 GEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTS 2887
Query: 423 DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP 482
F+ + +SCN GY++ G QC + W+ P P CKV C G +K
Sbjct: 2888 GNG---FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKR 2944
Query: 483 QHQFVRPD------VNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
+ + + V C GY L GS CQ W + C I C P V N
Sbjct: 2945 ESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA 3004
Query: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
+G E + +G+TV Y+C + SL+G+S+ C N G WSG P C
Sbjct: 3005 VLSG---EKYTFGSTVHYSCTG------KRSLLGQSSRTCQLN----GHWSGSQPHCSGD 3051
Query: 597 LLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPV 656
+G S +E+ + TV + C +G+ L GS + C A+ +W P
Sbjct: 3052 ATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPE 3108
Query: 657 CEKETCQH----VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
C+ C + + + + V SC +GY L+G + + C NG W +P
Sbjct: 3109 CKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC--TANGTWSGTLP 3166
Query: 713 LCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFY--LLGEKKLQCRSDSKGHG 770
C +I C P + NG G ++++ G VSY C G+ L G + C + G
Sbjct: 3167 NCTIISCGDPGIPANGLRYG---DDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN----G 3219
Query: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
+WSG P C CP P +L T+ + + I Y+ C+PG+ ++ V+ C
Sbjct: 3220 TWSGVMPTCR----AVTCPTPPQISNGRLEGTNFDWGFS-ISYI-CSPGYELSFPAVLTC 3273
Query: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
+ TW VP C+ K F G P P G G + S + +SC+ ++LVG +
Sbjct: 3274 VGNGTWSGEVPQCLPK-FCGDPGIPA--QGKREGKSFIYQS---EVSFSCNFPFILVGSS 3327
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKM-YQYGAVVTLECEDGYMLEG 949
+C +GTWS +PHC E +S + + G + +Q G+VV C+ G++L+G
Sbjct: 3328 TRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG 3387
Query: 950 SPQSQCQSDHQWN 962
S C D W+
Sbjct: 3388 STTRTCLPDLTWS 3400
Score = 249 bits (635), Expect = 1e-65
Identities = 245/905 (27%), Positives = 368/905 (40%), Gaps = 157/905 (17%)
Query: 154 CPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCE 211
C P + N +E+ G + Y C G+ LVG I+ C + PP C+
Sbjct: 2395 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2453
Query: 212 ------EARCKSLG---------RFPNGKV-----------------------KEPPILR 233
E R S G +PN ++ KE +L+
Sbjct: 2454 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQ 2513
Query: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQG----VAWTKMPVCEE---------IFCPSPP 280
V N L G SS I G + W+ + +C +P
Sbjct: 2514 VYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPE 2573
Query: 281 PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAP 340
+G I + ++ S+V + CD F L+G+S+ C S W P P
Sbjct: 2574 SPPHGYIISQTGGQLN--SVVRWACDR------GFRLVGKSSAVCRKSSYGYHAWDAPVP 2625
Query: 341 RCELSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR---CNAQ 396
C+ A+ C P+ G +++ Y V + C G+ L SK++ C +
Sbjct: 2626 ACQ----AISCGIPKAPTNGGILTTD---YLVGTRVTYFCNDGYRLS-SKELTTAVCQSD 2677
Query: 397 GTWEP--SAPVCEK-ECQAPPNIL--NGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESI 451
GTW P C C + + + +G+ + ++ T + +SC+PGY +G SI
Sbjct: 2678 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2737
Query: 452 QCTSEGVWT--PPVPQCKVAACEATGRQLLTKPQHQFVRPDVNS------SCGEGYKLSG 503
+C G W+ P C++ +C +L T P + + +C G+ L G
Sbjct: 2738 ECLPNGTWSWRNERPYCQIISCG----ELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2793
Query: 504 SVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERG 563
S +EC + W C C P +I NG G E++ Y TV Y CNPG
Sbjct: 2794 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG---- 2846
Query: 564 VEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP--YF 621
F LIG S C Q+ WSG P C + V C H G I G+ + +
Sbjct: 2847 --FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFN 2892
Query: 622 YNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE-- 679
+ND VTF C G+ ++G ++ +C+A+ W P+C+ C S +PA S+ E
Sbjct: 2893 FNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC-----SDPGIPANSKRESK 2947
Query: 680 ----------LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGK 729
+V C GY L G + +CQ NG W K +P C +I C P V N
Sbjct: 2948 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP--NGQWDKPLPECIMIDCGHPGVPPNAV 3005
Query: 730 HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP 789
+G E + +G+ V Y C LLG+ C+ + G WSG P C T C
Sbjct: 3006 LSG---EKYTFGSTVHYSCTGKRSLLGQSSRTCQLN----GHWSGSQPHCSGDATGT-CG 3057
Query: 790 NPEVK-HGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAF 848
+P HG ++ S + V C+ G+I++GS C + +W P C KA
Sbjct: 3058 DPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA- 3111
Query: 849 IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908
+ C P T NG + FS S++YSC +GY+L G ++ CT GTWS P+C
Sbjct: 3112 VQCGNPGTTANGKVFRIDGTTFSS--SVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3169
Query: 909 EVNCSSPADMDGI-QKGLEPRKMYQYGAVVTLECEDGYMLE--GSPQSQCQSDHQWNPPL 965
++C P GI GL Y G V+ C+ GY +E GS C + W+ +
Sbjct: 3170 IISCGDP----GIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3225
Query: 966 AVCRS 970
CR+
Sbjct: 3226 PTCRA 3230
Score = 196 bits (499), Expect = 7e-50
Identities = 152/579 (26%), Positives = 240/579 (41%), Gaps = 89/579 (15%)
Query: 435 IKYSCNPGYVLVGEESIQCTSEG----VWTPPVPQCKVAAC----EATGRQLLTKPQHQF 486
++++C+ G+ LVG+ S C W PVP C+ +C T +LT
Sbjct: 2592 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDY--L 2649
Query: 487 VRPDVNSSCGEGYKLSGSVYQE--CQGTIPWFMEIRL--CKEITCPPPPV---------I 533
V V C +GY+LS CQ W + C +TCP I
Sbjct: 2650 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2709
Query: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS--GPAP 591
NG+H + Y T V ++C+PG + +G ++I C N GTWS P
Sbjct: 2710 VNGSH-------YEYKTKVVFSCDPG------YHGLGPASIECLPN----GTWSWRNERP 2752
Query: 592 LCKLSLLAVQCSHVHIA-NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTW 650
C++ + C + NG KI + + Y T F C GF L GS+ C + W
Sbjct: 2753 YCQI----ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLGFMLVGSAVRECLSSGLW 2805
Query: 651 DPEIPVCEKETCQHVRQSLQELPAGSRV--------ELVNTSCQDGYQLTGHAYQMCQDA 702
C C + EL +V + V C G++L G + ++CQ
Sbjct: 2806 SESETRCLAGHC-----GIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD 2860
Query: 703 ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762
N W ++P C + C P + G+ +G F + + V++ C+ G+ + G K QC
Sbjct: 2861 HN--WSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQC 2915
Query: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT--HSAYSHNDIVYVDCNPGF 820
+++ + WS P P C V C +P + K H +++ +V+ DCNPG+
Sbjct: 2916 QANRQ----WSHPPPMC----KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGY 2967
Query: 821 IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSC 880
+ GS V+ C + W +P CI I C P PN +G +++ G ++ YSC
Sbjct: 2968 FLFGSSVLICQPNGQWDKPLPECI---MIDCGHPGVPPNAVLSG---EKYTFGSTVHYSC 3021
Query: 881 DQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLE 940
L+G++ C G WS PHC + D G ++ + V
Sbjct: 3022 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYA 3081
Query: 941 CEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
C+ GY+L GS + C ++ W C++ V CG
Sbjct: 3082 CDTGYILHGSEERTCLANGSWTGRQPECKA-----VQCG 3115
Score = 117 bits (294), Expect = 4e-26
Identities = 228/1044 (21%), Positives = 366/1044 (35%), Gaps = 181/1044 (17%)
Query: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69
F+ P C S P GR AVG+ + + C+ + L G ++ C T
Sbjct: 1865 FVYQAVPRTSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1922
Query: 70 KVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS 129
W+ P C IVP G G R G ++ + N N
Sbjct: 1923 NSLAQWNDSLPTC------------IVPCG----GILTKRKGTILSPGYPEPYDNNLN-C 1965
Query: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTY---SCESG 186
VW ++ +L G + + +GS + G ++ + S +
Sbjct: 1966 VWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYS-GTTIPHLLNSTSNN 2024
Query: 187 YLLVGEKIINCLSSG---KWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFC 242
L + I+ ++G +++A+ +C E + S G +K VG +F C
Sbjct: 2025 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG------IKIGDRYMVGDVVSFQC 2078
Query: 243 DEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI- 300
D+GY LQG C+ G W +P+C C +G + S+
Sbjct: 2079 DQGYSLQGHSHITCM-PGPVRRWNYPIPICLAQ-CGGAMSDFSGVILSPGFPGNYPSSLD 2136
Query: 301 VTYTCDPDPEEGVNFILIGEST------LRCTVDSQKTGT----WSGPA-PRCELSTS-- 347
T+T + GV+ + ST L S +T T SGP P ST+
Sbjct: 2137 CTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHE 2196
Query: 348 ------------------------AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGF 383
CP P+ R V G +T T+ F C G+
Sbjct: 2197 TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND--FTVGQTISFECFPGY 2254
Query: 384 TLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441
TL G+ + C W P CE C +NG + PG +Y P
Sbjct: 2255 TLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNG-------TIYSPGYPDEY---P 2304
Query: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDVNS-SCG 496
+ + W VP T L T+P + F+ PD NS G
Sbjct: 2305 NF-----------QDCFWLVRVPPGNGIYINFT--VLQTEPIYDFITVWDGPDQNSPQIG 2351
Query: 497 E--GYKLSGSVYQECQGTIPWF----------------MEIRLCKEITCPPPPVIYNGAH 538
+ G SVY + F ++R+C+ PPPPV A
Sbjct: 2352 QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQ----PPPPV--PNAE 2405
Query: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL--- 595
+ ++F G + Y C PG F+L+G + + C ER G P+C++
Sbjct: 2406 ILTEDDEFEIGDIIRYQCLPG------FTLVGNAILTCRLG--ERLQMDGAPPVCQVLCP 2457
Query: 596 -SLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
+ L + + V ++ GY S + +S KG + + E
Sbjct: 2458 ANELRLDSTGVILSPGYPDS--------YPNLQMCAWSISVEKGYNITMFVEFFQTEKEF 2509
Query: 655 PVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
V + +++ + +G N + GH + A++G K +
Sbjct: 2510 DVLQVYDGPNIQSPVLISLSGDYSSAFNITS------NGHEVFLQWSADHGNNKKGFRIR 2563
Query: 715 KV-IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
+ +C P +G + V + CD+GF L+G+ CR S G+ +W
Sbjct: 2564 YIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2621
Query: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR--CH 831
P P C C P+ + T Y V CN G+ ++ + C
Sbjct: 2622 APVPAC----QAISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQ 2675
Query: 832 TDNTWV--PGVPTCIKKAFIGCPPPPK--TPNGNHTGGNIARFSPGMSILYSCDQGYLLV 887
+D TW P C+ + CP +G N + + +++SCD GY +
Sbjct: 2676 SDGTWSNHNKTPRCV---VVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2732
Query: 888 GEALLLCTHEGTWS--QPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVVTLECEDG 944
G A + C GTWS P+C+ ++C P +G + G + YG+ C+ G
Sbjct: 2733 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLG 2788
Query: 945 YMLEGSPQSQCQSDHQWNPPLAVC 968
+ML GS +C S W+ C
Sbjct: 2789 FMLVGSAVRECLSSGLWSESETRC 2812
Score = 99.0 bits (245), Expect = 2e-20
Identities = 78/276 (28%), Positives = 114/276 (41%), Gaps = 24/276 (8%)
Query: 14 VAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDG 73
V P ++C +PP I NGR+ T G I Y CS + L L C+ +G
Sbjct: 3224 VMPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVG----NG 3277
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
TW P+C K+ C +P +P K G + + + V+F+C F + G+ + CQ
Sbjct: 3278 TWSGEVPQC--LPKF--CGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILVGSSTRICQ 3332
Query: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
A+ W + P C+ C P +P H + N G V + C+ G+LL G
Sbjct: 3333 ADGTWSGSS-PHCIEPTQTSCENPGVPR----HGSQNNTFGFQVGSVVQFHCKKGHLLQG 3387
Query: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
CL WS + P C CK + V + G T + C G+ L G
Sbjct: 3388 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGG 3447
Query: 252 PSSRCVIAGQGVAWT-KMPVCE---EIFCPSPPPIL 283
R + WT K+P+CE +I P P L
Sbjct: 3448 TEHR--VCRSDNTWTGKVPICEAGSKILVKDPRPAL 3481
Score = 79.0 bits (193), Expect = 2e-14
Identities = 212/1013 (20%), Positives = 345/1013 (34%), Gaps = 220/1013 (21%)
Query: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149
SC +P +P + G + G +V+F+C + + ++ + + C+ N+ W LPTC ++
Sbjct: 1009 SCLDPGIPVHGRRYGHD-FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP-LPTCDAL 1066
Query: 150 F---------PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCES-------GYLLVGEK 193
+ P P + + G V ++ + YLL+ E
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1126
Query: 194 --IINCLSSGKWSAVPPTCE-------EARCKSLGRFPNG--------------KVKEPP 230
L+ S +PPT A+ + + F ++P
Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1186
Query: 231 ILR----------VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC--------- 271
I + +G T F C GYRL+G C+ G+ V +P C
Sbjct: 1187 IPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASAT 1246
Query: 272 -EEIFCPSPPPILN-----------------GRHIGNSLANVSYGSIVTYTCDPDPEEGV 313
E SP LN G +I +++ G ++ D +
Sbjct: 1247 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHL 1306
Query: 314 NFILIGESTLRCTVDSQKTGTW-------SGPAPRCELSTSAVQCPH------PQILRGR 360
G S T+ S W G +L ++ + H PQ G
Sbjct: 1307 LGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GY 1364
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILN 418
+S Q + T+I+ C G+TL GS ++C + W+ P C EC
Sbjct: 1365 KISDQG--HFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG------ 1416
Query: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL 478
RF G S +PGY + +++C +W V + + +
Sbjct: 1417 ---------RFK-GESSGRILSPGYPFPYDNNLRC----MWMIEVDPGNIVSLQFLAFD- 1461
Query: 479 LTKPQHQFVR----PDVNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLCKE---- 524
T+ H +R P N + ++SGS+ E TI + + + K
Sbjct: 1462 -TEASHDILRVWDGPPENDMLLK--EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAI 1518
Query: 525 -------ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCT 577
C P V NG G E G TV + C+PG + L GE I C
Sbjct: 1519 QFSSSVATACRDPGVPMNGTRNGDGREP---GDTVVFQCDPG------YELQGEERITCI 1569
Query: 578 SNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYN-----------DT 625
+ R W P+C +A ++ ++G+ +S PY ++ D
Sbjct: 1570 QVEN-RYFWQPSPPVC----IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADY 1624
Query: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSC 685
V + F+++ + D D P+ S Q+ R+E + +
Sbjct: 1625 VISLAFISFSIEPNYDFLYIYDGP-DSNSPLIG---------SFQDSKLPERIESSSNTM 1674
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
++ G E ++ C P I+NG GM ++ G+ V+
Sbjct: 1675 HLAFRSDGSVSYTGFHLEYKAKLRE-------SCFDPGNIMNGTRLGM---DYKLGSTVT 1724
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE---VKHGYKLNKT 802
Y CD G+ L G L C G W+ P C +P +R E + Y N
Sbjct: 1725 YYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKN-- 1781
Query: 803 HSAYSHNDIVYVDCNPGFIMNGSRVI--RCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG 860
+ HN + + F++ G V D V PT + +G
Sbjct: 1782 -YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLL-------SSLSG 1833
Query: 861 NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMD 919
+H+G ++ S G I + VG H Q P CSS P
Sbjct: 1834 SHSGESLP-LSSGNQITIR----FTSVGPITAKGFH--FVYQAVPRTSSTQCSSVPEPRF 1886
Query: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ----SDHQWNPPLAVC 968
G + G E + G+ V +C GY+L GS +C+ S QWN L C
Sbjct: 1887 GRRIGNE----FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1935
Score = 68.6 bits (166), Expect = 3e-11
Identities = 170/817 (20%), Positives = 277/817 (33%), Gaps = 159/817 (19%)
Query: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-------------------- 82
+G + +SCS +RL G ++C+ + W P P+C
Sbjct: 1200 IGDTLTFSCSSGYRLEGTSEIICLGGGR--RVWSAPLPRCVAECGASATNNEGILLSPNY 1257
Query: 83 --EYFNKYSSCPEPIVPGGYKIRGSTPYRH---GDSV-----------TFACKTNFSMNG 126
Y N + V G I S H GD + T SM G
Sbjct: 1258 PLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRG 1317
Query: 127 ------NKSVWCQANNMW-----GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP 175
+ +W + N+ G + T + E P +P G+ S+ G A
Sbjct: 1318 LTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQ-GHFA- 1373
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233
G ++ Y C GY L G ++ C++ + W P+C A C GRF
Sbjct: 1374 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAECG--GRFK----------- 1419
Query: 234 VGVTANFFCDEGYRLQGPPSSRC----------VIAGQGVAWTKMPVCEEIFCPSPPPIL 283
G ++ GY + RC +++ Q +A+ + + PP
Sbjct: 1420 -GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP-- 1476
Query: 284 NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCE 343
+ L GS++ EG++ L + + D+ + SG A +
Sbjct: 1477 ----ENDMLLKEISGSLI--------PEGIHSTL---NIVTIQFDTDFYISKSGFAIQFS 1521
Query: 344 LSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWE 400
S+ A C P + +G D DTV+F C G+ L+G ++I C + W+
Sbjct: 1522 -SSVATACRDPGVPMNGTRNG--DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQ 1578
Query: 401 PSAPVCEKECQAPPNILNG---QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457
PS PVC C +G H + N YV+ S+ S
Sbjct: 1579 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI----SLAFISFS 1634
Query: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE---GYKLSGSVYQECQGTIP 514
+ P + + L+ Q + + SS ++ GSV
Sbjct: 1635 I-EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV-----SYTG 1688
Query: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
+ +E + +C P I NG G D+ G+TVTY C+ G + L G ST+
Sbjct: 1689 FHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYSTL 1739
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFK 629
C D R W+ P C H G + +G E Y N +V
Sbjct: 1740 TCIMGDDGRPGWNRALPSC------------HAPCGSRSTGSEGTVLSPNYPKNYSVGHN 1787
Query: 630 CYSGFTLKGSSQIRCK---ADNTWDPEIPVCEKETCQ-HVRQSLQELPAGSRVELVNTSC 685
C + + + + + V + T Q + SL +G + L
Sbjct: 1788 CVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPL----- 1842
Query: 686 QDGYQLTGHAYQMCQDAENGIWF--KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743
G Q+T + G F + +P C P G+ G F G+
Sbjct: 1843 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSS 1899
Query: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
V ++C+ G+ L G ++C + W+ P C+
Sbjct: 1900 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1936
Score = 62.8 bits (151), Expect = 2e-09
Identities = 102/447 (22%), Positives = 162/447 (36%), Gaps = 79/447 (17%)
Query: 233 RVGVTANFFCDEGYRLQGPPSSRCVIAGQG-VAWTK-MPVCEEIFCPSPPPILNGRHIG- 289
++G T ++CD GY LQG + C++ G W + +P C C S G +
Sbjct: 1718 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLSP 1776
Query: 290 NSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
N N S G Y+ E F++ G+ T + GP + L +S
Sbjct: 1777 NYPKNYSVGHNCVYSIAVPKE----FVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1832
Query: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE 409
+ L + SG + T+ F + T KG + ++ +
Sbjct: 1833 GSHSGESLP--LSSGNQI------TIRFTSVGPITAKGFHFV-------YQAVPRTSSTQ 1877
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQ 465
C + P G++ F G+S+ + CNPGY+L G +I+C S W +P
Sbjct: 1878 CSSVPEPRFGRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1934
Query: 466 CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525
C + C +LTK + + P Y E P+ + +I
Sbjct: 1935 C-IVPCGG----ILTKRKGTILSPG---------------YPE-----PYDNNLNCVWKI 1969
Query: 526 TCPP------PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579
T P V + H SL+ + G N P G + TSN
Sbjct: 1970 TVPEGAGIQVQVVSFATEHNWDSLDFYDGGD------NNAPRLGSYSGTTIPHLLNSTSN 2023
Query: 580 D---QERGTWSGPAPLCKLSLLAV---QCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYS 632
+ + S A L A+ C ++G KI + Y D V+F+C
Sbjct: 2024 NLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDR---YMVGDVVSFQCDQ 2080
Query: 633 GFTLKGSSQIRCKAD--NTWDPEIPVC 657
G++L+G S I C W+ IP+C
Sbjct: 2081 GYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Score = 59.7 bits (143), Expect = 1e-08
Identities = 142/694 (20%), Positives = 232/694 (33%), Gaps = 178/694 (25%)
Query: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335
CP P NG+ IG+ S GS V ++CD D ++L G ++ C ++ W
Sbjct: 486 CPDPGEPENGKRIGSDF---SLGSTVQFSCDED------YVLQGAKSITCQRIAEVFAAW 536
Query: 336 SGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNA 395
S P C++ T G + G +T + F F Q NA
Sbjct: 537 SDHRPVCKVKTC-----------GSNLQGPSGTFTSPN-------FPF------QYDSNA 572
Query: 396 QGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTS 455
Q W +A K Q +N ++ D + +G +++
Sbjct: 573 QCVWVITAVNTNKVIQ-----INFEEFD--------------------LEIGYDTLTIGD 607
Query: 456 EGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE-GYKLSGSVYQECQGTIP 514
G P +V +++ ++ + S G G+K++ Y+E +
Sbjct: 608 GGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN---YKEIE---- 660
Query: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
KE +C P G G + F + + C G F LIGE +I
Sbjct: 661 --------KE-SCGDPGTPLYGIREG---DGFSNRDVLRFECQFG------FELIGEKSI 702
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVT------- 627
C N+Q WS P+C C A + + P Y + +
Sbjct: 703 VCQENNQ----WSANIPIC-----IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIIS 753
Query: 628 ------FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELV 681
++ F L+ D PE P+ T V L S ++
Sbjct: 754 DPGSRIHLSFNDFDLESQFDFLAVKDGD-SPESPILGTFTGAEVPSHLT-----SNSHIL 807
Query: 682 NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741
Q + ++G + + + C P + +N + G +NF G
Sbjct: 808 RLEFQADHSMSGRGFNITYNTFGH-----------NECPDPGIPINARRFG---DNFQLG 853
Query: 742 NEVSYECDQGFY-LLGEKKLQCRSDSKGHGSWSGPSPQCLR------SPPVTRCPNP--- 791
+ +S C++GF G + + C G WSG P+C S P +P
Sbjct: 854 SSISVICEEGFIKTQGTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWP 912
Query: 792 -------------EVKHGYKLNKTHSAYS---HNDIVYVDCNPGFI------MNGSRV-- 827
E + G+ + T + + D++ V P + NG++V
Sbjct: 913 GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQ 972
Query: 828 ----------IRCHTDNTWV-PGVPTCIKKAFI---GCPPPPKTPNGNHTGGNIARFSPG 873
+ TDN+ G + + C P +G G + FS G
Sbjct: 973 FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIG 1029
Query: 874 MSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 907
++ +SCD GY L E LLC WS P P C
Sbjct: 1030 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 49.3 bits (116), Expect = 2e-05
Identities = 171/840 (20%), Positives = 278/840 (33%), Gaps = 172/840 (20%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG P L G + V+R+ C F LIGEKS++C + + W P
Sbjct: 663 SCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVC----QENNQWSANIPI 716
Query: 82 C------EYFNKYSSCPEPIVPGGYK---------IRGSTPYRHGDSVTFACKTNFSMNG 126
C + + P P GY I H F ++ F
Sbjct: 717 CIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLA 776
Query: 127 NKSVWCQANNMWG-------PTRLPTCVSVFPLECPA--------LPMIHN--GHHTSEN 169
K + + G P+ L + + LE A + +N GH+ +
Sbjct: 777 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPD 836
Query: 170 VG----------SIAPGLSVTYSCESGYLLV-GEKIINC-LSSGK--WSAVPPTCEEARC 215
G + G S++ CE G++ G + I C L GK WS + P C A C
Sbjct: 837 PGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-GAPC 895
Query: 216 KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIF 275
P+G + P G+ S C + + + E F
Sbjct: 896 GGHFSAPSGVILSP---------------GWPGYYKDSLNCEWVIEAEPGHSIKITFERF 940
Query: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE---EGVNFILIGESTLRCTVDSQKT 332
+ H G +L + GS Y P+ NFI L T D+ ++
Sbjct: 941 QTELNYDVLEVHDGPNLLSPLLGS---YNGTQVPQFLFSSSNFIY-----LLFTTDNSRS 992
Query: 333 GTWSGPAPRCE-LSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQ 390
+G E ++ + C P I + GR ++ TV F+C G+ L +
Sbjct: 993 N--NGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEP 1047
Query: 391 IRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES 450
+ C W P C+ C VR GT + +PGY S
Sbjct: 1048 LLCEKNHWWSHPLPTCDALCGGD-------------VRGPSGTIL----SPGYPEFYPNS 1090
Query: 451 IQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY-KLSGS----- 504
+ CT WT V K + + H ++ N S + +L+GS
Sbjct: 1091 LNCT----WTVDVTHGK--GVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPT 1144
Query: 505 ----VYQECQGTIPWFMEIRLCKE---IT--------CPPPPVIYNGAHTGSSLEDFPYG 549
+Y + + + + + E IT C P + G+ G +F G
Sbjct: 1145 INAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGF---NFGIG 1201
Query: 550 TTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN 609
T+T++C+ G + L G S I C R WS P P C +C N
Sbjct: 1202 DTLTFSCSSG------YRLEGTSEIICLGGG--RRVWSAPLPRC-----VAECGASATNN 1248
Query: 610 GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE----KETCQHV 665
+ P Y + +C ++ I A + V + K+ H+
Sbjct: 1249 EGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHL 1306
Query: 666 -----RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH 720
S++ L S + + T +Q+ + ++ HC
Sbjct: 1307 LGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS-----------FELSHCE 1355
Query: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
P + G + + G+ + Y C+ G+ L G L+C + + +W P P C+
Sbjct: 1356 DPGIPQFGYK--ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGER--RAWDYPLPSCI 1411
Score = 45.1 bits (105), Expect = 4e-04
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH----EGT 899
IK A CP P + NG G + FS G ++ +SCD+ Y+L G + C
Sbjct: 479 IKTASNLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 535
Query: 900 WSQPAPHCKEVNCSS 914
WS P CK C S
Sbjct: 536 WSDHRPVCKVKTCGS 550
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 34/252 (13%)
Query: 606 HIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT----WDPEIPVCEKET 661
+I NG ++ Y TVT+ C +G+ L+G S + C + W+ +P C
Sbjct: 1706 NIMNGTRLG---MDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC 1762
Query: 662 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGH--AYQMCQDAENGIWFKKIPLCKVIHC 719
GS +++ + Y + GH Y + E ++ + + +H
Sbjct: 1763 GSR--------STGSEGTVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLHD 1813
Query: 720 HPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--P 777
V + G ++ L + + L ++ R S G + G
Sbjct: 1814 ------VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1867
Query: 778 QCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT- 835
Q + T+C + PE + G ++ + S V DCNPG+I++GS IRC T
Sbjct: 1868 QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSS---VLFDCNPGYILHGSIAIRCETVPNS 1924
Query: 836 ---WVPGVPTCI 844
W +PTCI
Sbjct: 1925 LAQWNDSLPTCI 1936
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQCKVA-ACEATGR 476
RFD G I+YSC GY+L G + C + V W PVP C+ AC T R
Sbjct: 193 RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMR 246
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG+P G + Y T VG IRYSC + L G L CI +WD P P
Sbjct: 177 SCGNPGVPPKGVL--YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 82 C 82
C
Sbjct: 235 C 235
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/262 (20%), Positives = 91/262 (34%), Gaps = 42/262 (16%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C P NGK G +F G+ V + CD+ + L G K + C+ ++ +WS P
Sbjct: 486 CPDPGEPENGKRIG---SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542
Query: 779 C--------LRSPPVTRCPNPEVKHGYKLNK----THSAYSHNDIVYVDCNPGFIMNGSR 826
C L+ P T +P Y N +A + N ++ ++ + G
Sbjct: 543 CKVKTCGSNLQGPSGT-FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 601
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886
+ G P + + G P I S M + D+
Sbjct: 602 TLTIGDGGE--VGDPRTVLQVLTGSFVPDL----------IVSMSSQMWLHLQTDESVGS 649
Query: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946
VG + + KE+ S D G+ + V+ EC+ G+
Sbjct: 650 VGFKV--------------NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 695
Query: 947 LEGSPQSQCQSDHQWNPPLAVC 968
L G CQ ++QW+ + +C
Sbjct: 696 LIGEKSIVCQENNQWSANIPIC 717
Score = 38.9 bits (89), Expect = 0.025
Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 36/261 (13%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC P I+NG + +G+ + Y C + L G +L CI D W++ P
Sbjct: 1700 SCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757
Query: 82 CEYFNKYSSCPEPIVPGGYKIRG------STPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
C P G + G S Y SV C + ++ V+ Q
Sbjct: 1758 CH------------APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQF- 1804
Query: 136 NMWGPTRLPTCVSVF--PLECPALPMIHNGHHTSENVG-SIAPGLSVTYSCESGYLLVGE 192
++ T L V V+ P + +L +G H+ E++ S +++ ++ G
Sbjct: 1805 -VFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF 1863
Query: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPP 252
+ + AVP T +C S+ P + VG + F C+ GY L G
Sbjct: 1864 HFV-------YQAVPRT-SSTQCSSVPE-PRFGRRIGNEFAVGSSVLFDCNPGYILHGSI 1914
Query: 253 SSRCVIAGQGVA-WT-KMPVC 271
+ RC +A W +P C
Sbjct: 1915 AIRCETVPNSLAQWNDSLPTC 1935
Score = 37.7 bits (86), Expect = 0.056
Identities = 74/300 (24%), Positives = 108/300 (36%), Gaps = 61/300 (20%)
Query: 215 CKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCE 272
C G NGK + +G T F CDE Y LQG S C IA AW+ PVC+
Sbjct: 486 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544
Query: 273 EIFCPSPPPILNGRHIGNSL-----ANVSYGSIVTYTCDPDPEEGVNF----ILIGESTL 323
C S +G + +N ++T + + +NF + IG TL
Sbjct: 545 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDTL 603
Query: 324 RCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV-------SGQKDRYTYNDTVI 376
D + G PR L Q+L G V S Q + D +
Sbjct: 604 TIG-DGGEVGD-----PRTVL----------QVLTGSFVPDLIVSMSSQMWLHLQTDESV 647
Query: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436
+ F K ++ C GT P + E + +R ++RF+
Sbjct: 648 GSVGFKVNYKEIEKESCGDPGT--PLYGIREGD----------GFSNRDVLRFE------ 689
Query: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496
C G+ L+GE+SI C W+ +P C + C + T P + PD G
Sbjct: 690 --CQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSN----FTAPMGTVLSPDYPEGYG 742
Score = 35.8 bits (81), Expect = 0.21
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 7/62 (11%)
Query: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC----THEGTWSQPAPH 906
C P P G G RF G I YSC GY+L G L C + +W P P
Sbjct: 178 CGNPGVPPKGVLYG---TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 907 CK 908
C+
Sbjct: 235 CR 236
Score = 35.8 bits (81), Expect = 0.21
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 6/49 (12%)
Query: 931 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
+ G+ V+ C+ GY L C+ +H W+ PL C LCG
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC------DALCG 1068
Score = 35.0 bits (79), Expect = 0.37
Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 9/81 (11%)
Query: 154 CPALPMIHNGHHTSENVGS-IAPGLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPP 208
CP NG + +GS + G +V +SC+ Y+L G K I C + WS P
Sbjct: 486 CPDPGEPENG----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 541
Query: 209 TCEEARCKSLGRFPNGKVKEP 229
C+ C S + P+G P
Sbjct: 542 VCKVKTCGSNLQGPSGTFTSP 562
Score = 34.7 bits (78), Expect = 0.48
Identities = 15/42 (35%), Positives = 22/42 (52%)
Query: 738 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC 779
F G+++ Y C G+ L G +L C ++S SW P P C
Sbjct: 194 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 33.1 bits (74), Expect = 1.4
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH----QWNP 963
+E+ SS + KG+ + G + C GY+L+G PQ C ++ W+
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 964 PLAVCRS 970
P+ +CR+
Sbjct: 231 PVPICRA 237
Score = 32.3 bits (72), Expect = 2.4
Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 89 SSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
SSC P VP + G T + GD + ++C T + ++G+ + C AN++
Sbjct: 176 SSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 223
Score = 32.3 bits (72), Expect = 2.4
Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 91 CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
CP+P P K GS + G +V F+C ++ + G KS+ CQ
Sbjct: 486 CPDPGEPENGKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQ 527
Score = 31.6 bits (70), Expect = 4.0
Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 14/73 (19%)
Query: 522 CKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQ 581
C PP V+Y F G + Y+C G + L G + C +N
Sbjct: 178 CGNPGVPPKGVLYGTR--------FDVGDKIRYSCVTG------YILDGHPQLTCIANSV 223
Query: 582 ERGTWSGPAPLCK 594
+W P P+C+
Sbjct: 224 NTASWDFPVPICR 236
Score = 31.2 bits (69), Expect = 5.3
Identities = 17/59 (28%), Positives = 26/59 (44%), Gaps = 5/59 (8%)
Query: 176 GLSVTYSCESGYLLVGEKIINCL----SSGKWSAVPPTCE-EARCKSLGRFPNGKVKEP 229
G + YSC +GY+L G + C+ ++ W P C E C R +G + P
Sbjct: 197 GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 255
Score = 31.2 bits (69), Expect = 5.3
Identities = 16/61 (26%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C P NG+ + ++G+ +++SC + L G KS+ C +V W P C
Sbjct: 486 CPDPGEPENGK--RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 83 E 83
+
Sbjct: 544 K 544
Score = 30.8 bits (68), Expect = 6.9
Identities = 15/64 (23%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 932 QYGAVVTLECEDGYMLEGSPQSQCQSD----HQWNPPLAVCRSRSLAPVLCGIAAGLILL 987
Q +VV C+ G+ L G + C+ H W+ P+ C++ S G++
Sbjct: 2587 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTT 2646
Query: 988 TFLI 991
+L+
Sbjct: 2647 DYLV 2650
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 320 bits (820), Expect = 4e-87
Identities = 269/982 (27%), Positives = 404/982 (41%), Gaps = 103/982 (10%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C P+ NG I T AVG+ + Y C +R++G + C WD P C
Sbjct: 2433 CSLTHPLKNGGI-LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLC 2491
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGP 140
+ SC P PG G+ + V + C F + ++ CQ + +W
Sbjct: 2492 QAV----SCGIPESPGNGSFTGNE-FTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSN 2546
Query: 141 T-RLPTCVSVFPLECPALPMIHNGHHTSENV-GSIAP-GLSVTYSCESGYLLVGEKIINC 197
+ PTC P+ CP++ + H V GS+ G V SC GY L G +++ C
Sbjct: 2547 KGKPPTCK---PVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRC 2603
Query: 198 LSSGKWSAVP--PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
++G W+ P+C C SL PNG K + G TA F C+ GY L G
Sbjct: 2604 QANGTWNIGDERPSCRVISCGSLSFPPNGN-KIGTLTVYGATAIFTCNTGYTLVGSHVRE 2662
Query: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+ G W+ C C SP PI+NG G+ SY V Y C+P
Sbjct: 2663 CLANG---LWSGSETRCLAGHCGSPDPIVNGHISGDGF---SYRDTVVYQCNP------G 2710
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
F L+G S C D + WSG P C + C HP +G + + ND
Sbjct: 2711 FRLVGTSVRICLQDHK----WSGQTPVCV----PITCGHPGNPAHGFTNGSE--FNLNDV 2760
Query: 375 VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMV--RFDP 431
V F C G+ L+G + +C + G W P C C P + N + + F+
Sbjct: 2761 VNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEY 2820
Query: 432 GTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLLTKPQHQFVR 488
G SI Y C G+ L+G ++ C + G+W +P+C +C G +LT +
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGA 2880
Query: 489 PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEIT---CPPPPVIYNGAHTGSSLED 545
V+ SC L G+ + CQ W + C C P +G+ G +D
Sbjct: 2881 V-VHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLG---DD 2936
Query: 546 FPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHV 605
F + + ++C G + L G C N G+WSG P+C+ AV C +
Sbjct: 2937 FKTKSLLRFSCEMGHQ------LRGSPERTCLLN----GSWSGLQPVCE----AVSCGNP 2982
Query: 606 HIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHV 665
I + F + +V + C+ G+ G C A+ TW P C +C
Sbjct: 2983 GTPTNGMIVSSDGILF-SSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDP 3041
Query: 666 RQSLQELPAGSRV---ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPP 722
+ G+ + V+ C GY + + ++G W P+CK + C P
Sbjct: 3042 GTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQP 3101
Query: 723 PVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRS 782
P + NG G +F +G+ +SY C G+ L L C +G G W G PQCL
Sbjct: 3102 PPVQNGTVEG---SDFRWGSSISYSCMDGYQLSHSAILSC----EGRGVWKGEIPQCL-- 3152
Query: 783 PPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPT 842
PV C +P + +L+ ++++ V+ C FI+ GS C D TW PT
Sbjct: 3153 -PVF-CGDPGIPAEGRLSG--KSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPT 3208
Query: 843 CIKKAFIGCPPPPKTPNGNHTG-GNIAR-FSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
CI A CP P TP H G N +R + G ++ + C +GY + G C TW
Sbjct: 3209 CIDPAHNTCPDPG-TP---HFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTW 3264
Query: 901 S----QPAPH-CKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLE-GSPQSQ 954
S + PH C++ + AD+ I + +G + C G+ L GS
Sbjct: 3265 SGIQTECIPHACRQPETPAHADVRAID-------LPTFGYTLVYTCHPGFFLAGGSEHRT 3317
Query: 955 CQSDHQWNPPLAVCRSRSLAPV 976
C++D +W VC+S+ + V
Sbjct: 3318 CKADMKWTGKSPVCKSKGVREV 3339
Score = 265 bits (676), Expect = 2e-70
Identities = 244/985 (24%), Positives = 392/985 (39%), Gaps = 114/985 (11%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C PP + + +G ++Y C + L+G L C ++ ++ P C
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQ--FEGSLPTC 2316
Query: 83 EYFNKYSSCPEPIV---PGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
E + CP V G + P + +S T + N N +++ +
Sbjct: 2317 E-----AQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDT---FQ 2368
Query: 140 PTRLPTCVSVFPL---ECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIIN 196
+ + VF + P L ++ H N S + L + +S + G KI
Sbjct: 2369 SEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKI-- 2426
Query: 197 CLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRC 256
+++A C NG + VG ++FC GYR+ G ++ C
Sbjct: 2427 -----RYAA-------PYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATC 2474
Query: 257 VIAGQGV-AWTKM-PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
G+ W + P+C+ + C P NG GN + S V Y C EG
Sbjct: 2475 RRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEF---TLDSKVVYEC----HEGFK 2527
Query: 315 FILIGESTLRCTVDSQKTGTWS--GPAPRCE-LSTSAVQCPHPQILRGRMVSGQKDRYTY 371
ES+ + T Q+ G WS G P C+ ++ +++ + + R+VSG + Y
Sbjct: 2528 L----ESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEY-- 2581
Query: 372 NDTVIFACMFGFTLKGSKQIRCNAQGTWE--PSAPVCEK-ECQAPPNILNGQKEDRHMVR 428
V+ +C G+ L+G + +RC A GTW P C C + NG K V
Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVY 2641
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL---LTKPQHQ 485
G + ++CN GY LVG +C + G+W+ +C C + + ++
Sbjct: 2642 ---GATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFS 2698
Query: 486 FVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLED 545
+ R V C G++L G+ + C W + +C ITC P N AH ++ +
Sbjct: 2699 Y-RDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPG---NPAHGFTNGSE 2754
Query: 546 FPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHV 605
F V +TCN G + L G S +C SN G WS P P C++ V CS
Sbjct: 2755 FNLNDVVNFTCNTG------YLLQGVSRAQCRSN----GQWSSPLPTCRV----VNCSDP 2800
Query: 606 -HIANGYKISGKEAP--YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC 662
+ N + + P + Y ++ + C GF L GSS + C A+ WD +P C +C
Sbjct: 2801 GFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISC 2860
Query: 663 QHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIH- 718
H + G +V+ SC+ L G+ ++CQ E+ W +P C +
Sbjct: 2861 GHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQ--EDSHWSGALPHCTGNNP 2918
Query: 719 --CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776
C P +G G ++F + + + C+ G L G + C + GSWSG
Sbjct: 2919 GFCGDPGTPAHGSRLG---DDFKTKSLLRFSCEMGHQLRGSPERTCLLN----GSWSGLQ 2971
Query: 777 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 836
P C C NP + + + ++Y C G+ +G C + TW
Sbjct: 2972 PVC----EAVSCGNPGTPTNGMIVSSDGILFSSSVIYA-CWEGYKTSGLMTRHCTANGTW 3026
Query: 837 VPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL--VGEALLLC 894
P C I C P NG G + F+ ++ Y C+ GY++ V A + C
Sbjct: 3027 TGTAPDC---TIISCGDPGTLANGIQFGTD---FTFNKTVSYQCNPGYVMEAVTSATIRC 3080
Query: 895 THEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954
T +G W+ P CK V C P +Q G +++G+ ++ C DGY L S
Sbjct: 3081 TKDGRWNPSKPVCKAVLCPQPPP---VQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILS 3137
Query: 955 CQSDHQWNPPLAVCRSRSLAPVLCG 979
C+ W + C PV CG
Sbjct: 3138 CEGRGVWKGEIPQC-----LPVFCG 3157
Score = 219 bits (559), Expect = 8e-57
Identities = 196/705 (27%), Positives = 292/705 (41%), Gaps = 96/705 (13%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P + I+CG P +G + + + V+ ++C+ + L G C + +G W
Sbjct: 2732 PVCVPITCGHPGNPAHGFTN--GSEFNLNDVVNFTCNTGYLLQGVSRAQC----RSNGQW 2785
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGST----PYRHGDSVTFACKTNFSMNGNKSVW 131
P P C N C +P G + +G S+ + CK F + G+ ++
Sbjct: 2786 SSPLPTCRVVN----CSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALT 2841
Query: 132 CQANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL 189
C AN +W + LP C+++ C P +P N T E G V YSC L
Sbjct: 2842 CMANGLWDRS-LPKCLAI---SCGHPGVPA--NAVLTGE---LFTYGAVVHYSCRGSESL 2892
Query: 190 VGEKIINCLSSGKWSAVPPTC---EEARCKSLGRFPNGK-----VKEPPILRVGVTANFF 241
+G C WS P C C G +G K +LR F
Sbjct: 2893 IGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLR------FS 2946
Query: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKM-PVCEEIFCPSPPPILNGRHIGNSLANVSYGSI 300
C+ G++L+G P C++ G +W+ + PVCE + C +P NG + + + + S
Sbjct: 2947 CEMGHQLRGSPERTCLLNG---SWSGLQPVCEAVSCGNPGTPTNGMIVSSD--GILFSSS 3001
Query: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
V Y C EG + G T CT + GTW+G AP C + + C P L
Sbjct: 3002 VIYAC----WEG--YKTSGLMTRHCTAN----GTWTGTAPDCTI----ISCGDPGTLANG 3047
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKG--SKQIRCNAQGTWEPSAPVCEKE-CQAPPNIL 417
+ G +T+N TV + C G+ ++ S IRC G W PS PVC+ C PP +
Sbjct: 3048 IQFGTD--FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQ 3105
Query: 418 NGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC-----E 472
NG E F G+SI YSC GY L + C GVW +PQC C
Sbjct: 3106 NGTVEGSD---FRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIP 3162
Query: 473 ATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI---TCPP 529
A GR L+ + + +V C + L GS + CQ W C + TCP
Sbjct: 3163 AEGR--LSGKSFTY-KSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD 3219
Query: 530 PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGP 589
P + G S + G+TV + C G + + G +T C +N TWSG
Sbjct: 3220 PGTPHFGIQNSS--RGYEVGSTVFFRCRKG------YHIQGSTTRTCLANL----TWSGI 3267
Query: 590 APLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIR-CKADN 648
C + C + + P F T+ + C+ GF L G S+ R CKAD
Sbjct: 3268 QTEC----IPHACRQPETPAHADVRAIDLPTF-GYTLVYTCHPGFFLAGGSEHRTCKADM 3322
Query: 649 TWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTG 693
W + PVC+ + + V +++ + P S V VN+ + Y+ G
Sbjct: 3323 KWTGKSPVCKSKGVREVNETVTKTPVPSDVFFVNSLWKGYYEYLG 3367
Score = 141 bits (356), Expect = 3e-33
Identities = 146/591 (24%), Positives = 236/591 (39%), Gaps = 83/591 (14%)
Query: 408 KECQAPPNILNGQK--EDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC--TSEGVWTPPV 463
K+CQ PP + + ED F+ G +KY C+PGY LVG + + C +S+ + +
Sbjct: 2257 KKCQPPPAVPQAEMLTEDDD---FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSL 2313
Query: 464 PQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFME-IRLC 522
P C+ A C A ++ T + P + S S+ E I F++ +
Sbjct: 2314 PTCE-AQCPA--NEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSE 2370
Query: 523 KEITC----------PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572
K+ P V+ +G HT S +F + Y + S
Sbjct: 2371 KQFDALEVFDGSSGQSPLLVVLSGNHTEQS--NFTSRSNQLY--------------LRWS 2414
Query: 573 TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYS 632
T TS ++G K+ A CS H I + A V + C
Sbjct: 2415 TDHATS---KKG--------FKIRYAAPYCSLTHPLKNGGILNRTAG-AVGSKVHYFCKP 2462
Query: 633 GFTLKGSSQIRCKAD----NTWDPEIPVCEKETCQHVRQSLQELPAGSRVEL---VNTSC 685
G+ + G S C+ + WD P+C+ +C G+ L V C
Sbjct: 2463 GYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYEC 2522
Query: 686 QDGYQL--TGHAYQMCQDAENGIWFK--KIPLCKVIHCHPPPVIVNGKHTGMMAENFL-- 739
+G++L + A +CQ E+G+W K P CK + C ++ + L
Sbjct: 2523 HEGFKLESSQQATAVCQ--EDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNE 2580
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKL 799
YG +V C G+YL G + L+C+++ + PS + + ++ PN
Sbjct: 2581 YGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNG-------- 2632
Query: 800 NKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 859
NK + + CN G+ + GS V C + W C+ C P N
Sbjct: 2633 NKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAG---HCGSPDPIVN 2689
Query: 860 GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPAD-M 918
G+ +G FS +++Y C+ G+ LVG ++ +C + WS P C + C P +
Sbjct: 2690 GHISGDG---FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPA 2746
Query: 919 DGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 969
G G E + VV C GY+L+G ++QC+S+ QW+ PL CR
Sbjct: 2747 HGFTNGSE----FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCR 2793
Score = 96.7 bits (239), Expect = 1e-19
Identities = 87/336 (25%), Positives = 138/336 (41%), Gaps = 40/336 (11%)
Query: 15 APGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGT 74
AP ISCG P + NG + T + Y C+ + + E + DG
Sbjct: 3030 APDCTIISCGDPGTLANG--IQFGTDFTFNKTVSYQCNPGY--VMEAVTSATIRCTKDGR 3085
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQA 134
W+ P C K CP+P + GS +R G S++++C + ++ + + C+
Sbjct: 3086 WNPSKPVC----KAVLCPQPPPVQNGTVEGS-DFRWGSSISYSCMDGYQLSHSAILSCEG 3140
Query: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI 194
+W +P C+ VF + P +P G + + S V + C+S ++LVG
Sbjct: 3141 RGVW-KGEIPQCLPVFCGD-PGIPA--EGRLSGK---SFTYKSEVFFQCKSPFILVGSSR 3193
Query: 195 INCLSSGKWSAVPPTCEEA---RCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
C + G WS + PTC + C G G VG T F C +GY +QG
Sbjct: 3194 RVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGS 3253
Query: 252 PSSRCV--IAGQGVAWTKMP-VCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPD 308
+ C+ + G+ +P C + P P + R I ++G + YTC P
Sbjct: 3254 TTRTCLANLTWSGIQTECIPHACRQ---PETPAHADVRAIDLP----TFGYTLVYTCHP- 3305
Query: 309 PEEGVNFILIGESTLR-CTVDSQKTGTWSGPAPRCE 343
F L G S R C D + W+G +P C+
Sbjct: 3306 -----GFFLAGGSEHRTCKADMK----WTGKSPVCK 3332
Score = 75.9 bits (185), Expect = 2e-13
Identities = 222/1060 (20%), Positives = 362/1060 (34%), Gaps = 226/1060 (21%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
+C P I+NG + T +G+ I Y C ++++ S+ C+ +WD+ P
Sbjct: 1564 ACFDPGNIMNG--TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPS 1621
Query: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPT 141
C + C G + S Y H + C +S+ K + T
Sbjct: 1622 CN-----APCGGQYT-GSEGVVLSPNYPHNYTAGQICL--YSITVPKEFVVFGQFAYFQT 1673
Query: 142 RLPTCVSVFPLECPALPMIH--NGHHTSENVG-SIAPGLSVTYSCESGYLLVGEKIINCL 198
L +F ++ +G H+ E + + + + + +S +SG G +
Sbjct: 1674 ALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFV--- 1730
Query: 199 SSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVI 258
+ AVP T + +C S+ G+ + G F C+ GY LQG + C
Sbjct: 1731 ----YQAVPRT-SDTQCSSVPEPRYGR-RIGSEFSAGSIVRFECNPGYLLQGSTALHCQS 1784
Query: 259 AGQGVA-WTK-----MPVCEEIFCPSPPPILNGRH---IGNSLANVSYGSIVTYTCDPDP 309
+A W + C F IL+ + GN+L N + IVT
Sbjct: 1785 VPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNL-NCIWKIIVT------E 1837
Query: 310 EEGVNFILIGESTLR----------CTVDSQKTGTWSGPAPRCELSTSAVQ--------- 350
G+ +I +T + V + + G++SG L++++ Q
Sbjct: 1838 GSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDI 1897
Query: 351 ------------------CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR 392
C P + + G DRY ND + F C G+TL+G I
Sbjct: 1898 SVAAAGFHLEYKTVGLAACQEPALPSNSIKIG--DRYMVNDVLSFQCEPGYTLQGRSHIS 1955
Query: 393 CNAQGT---WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE 449
C GT W +P+C C + L G V PG Y N
Sbjct: 1956 C-MPGTVRRWNYPSPLCIATCGGTLSTLGG-------VILSPGFPGSYPNN--------- 1998
Query: 450 SIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPD-----VNSSCGE--GYKLS 502
+ CT W +P A + T+ H F+ + G+ G L
Sbjct: 1999 -LDCT----WRISLPIGYGAHIQFL--NFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLP 2051
Query: 503 GSVYQECQGTIPWF------------MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGT 550
++ T+ F + + + CP PP NG S D+ G
Sbjct: 2052 AALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYMINS---DYSVGQ 2108
Query: 551 TVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANG 610
+V++ C PG + LIG + C W+ P P C G
Sbjct: 2109 SVSFECYPG------YILIGHPVLTCQHGINR--NWNYPFPRCDAPC------------G 2148
Query: 611 YKISGKE----APYFYNDTVTFK-------------CYSGFTLKGSSQIRCKADNTWD-P 652
Y ++ + +P F ++ K Y FTL + + WD P
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN-DYIAVWDGP 2207
Query: 653 EIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHA-YQMCQDAENGIWF-KK 710
+ Q+ +L S NT+ + Y T + D NG +F
Sbjct: 2208 D-------------QNSPQLGVFSG----NTALETAYSSTNQVLLKFHSDFSNGGFFVLN 2250
Query: 711 IPLCKVIHCHPPPVIVNGKHTGMMAE--NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKG 768
++ C PPP + + M+ E +F G+ V Y+C G+ L+G L C+ S+
Sbjct: 2251 FHAFQLKKCQPPPAVPQAE---MLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQ- 2306
Query: 769 HGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVI 828
+ G P C +CP EV+ G Y N C+ + + I
Sbjct: 2307 -LQFEGSLPTC-----EAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNI 2360
Query: 829 RCHTDNTWVPGVPTCIKKAFIGC---PPPPKTPNGNHT-GGNIARFSPGMSILYSCDQGY 884
D T+ + F G P +GNHT N S + + +S D
Sbjct: 2361 TIFVD-TFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHAT 2419
Query: 885 LLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDG 944
G + AP+C + + P GI R G+ V C+ G
Sbjct: 2420 SKKGFKI---------RYAAPYC---SLTHPLKNGGILN----RTAGAVGSKVHYFCKPG 2463
Query: 945 YMLEGSPQSQCQSD----HQWNPPLAVCRSRSLAPVLCGI 980
Y + G + C+ + +QW+ +C++ V CGI
Sbjct: 2464 YRMVGHSNATCRRNPLGMYQWDSLTPLCQA-----VSCGI 2498
Score = 72.0 bits (175), Expect = 3e-12
Identities = 194/895 (21%), Positives = 295/895 (32%), Gaps = 185/895 (20%)
Query: 165 HTSENVGSIAPGL----------SVTYSCESGYLLVGEKIINCLSS----GKWSAVPPTC 210
HT N G I G+ + YSC GY+L G I+ C+ S W P C
Sbjct: 143 HTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Query: 211 E-EARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP 269
E C R + + P N C + + P + +
Sbjct: 203 RAEGACGGTLRGTSSSISS-PHFPSEYENNADCT--WTILAEPGDTIALVFTDFQLEEGY 259
Query: 270 VCEEIFCPSPPPI-LNGRHIGNSLANVSYGSIVTYTCDPDPE-EGVNFILIGESTLRCTV 327
EI P I L G ++ + + + + +T D + +G N + ++ +
Sbjct: 260 DFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFN----AQFQVKKAI 315
Query: 328 DSQKTG-----TWSGPAPRCELSTSAV-----QCPHPQILR-GRMVSGQKDRYTYNDTVI 376
+ + G + G LS V CP P I GR R N V
Sbjct: 316 ELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGAN--VQ 373
Query: 377 FACMFGFTLKGSKQIRCN----AQGTWEPSAPVCE-----KECQAPPNILNG-----QKE 422
F+C + L+GSK I C W P+C + P ++ Q E
Sbjct: 374 FSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYE 433
Query: 423 DR-HMV----RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQ 477
D H V DP IK + + G +++ G V +
Sbjct: 434 DNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDL 493
Query: 478 LLTKPQHQFVRPDVNSSCGE-GYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
+++ ++ + S G G+K +VYQE + + C P + G
Sbjct: 494 IVSMSNQMWLHLQSDDSIGSPGFK---AVYQEIE-------------KGGCGDPGIPAYG 537
Query: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
TGSS F +G T+T+ C F L+GE I C N+Q WSG P C S
Sbjct: 538 KRTGSS---FLHGDTLTFECPAA------FELVGERVITCQQNNQ----WSGNKPSCVFS 584
Query: 597 LLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPE--- 653
C A+ I P Y + + C + S+I N +D E
Sbjct: 585 -----CFFNFTASSGIILSPNYPEEYGNNMN--CVWLIISEPGSRIHL-IFNDFDVEPQF 636
Query: 654 -IPVCEKETCQHVRQ----SLQELPA--GSRVELVNTSCQDGYQLTGHAYQMCQDA--EN 704
+ + + S E+P+ S +V Q + TG + + +N
Sbjct: 637 DFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQN 696
Query: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEKKLQCR 763
CH P + +NG+ G + FL G+ VS+ CD GF G + + C
Sbjct: 697 -------------ECHDPGIPINGRRFG---DRFLLGSSVSFHCDDGFVKTQGSESITCI 740
Query: 764 SDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKH--------------GYKLNKTHSAYSHN 809
G+ WS P RC P H GY + H +
Sbjct: 741 LQD-GNVVWSSTVP---------RCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEW--- 787
Query: 810 DIVYVDCNPGF---IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGN 866
++ PG I + D V P IG + P + GN
Sbjct: 788 ---IIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPAS-SSPLIGEYHGTQAPQFLISTGN 843
Query: 867 IARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMD-GIQ-KG 924
M +L++ D +G + H + V S + +D GI G
Sbjct: 844 F------MYLLFTTDNSRSSIGFLI--------------HYESVTLESDSCLDPGIPVNG 883
Query: 925 LEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
+ + VT C+ GY L C+ +HQWN L C LCG
Sbjct: 884 HRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC------DALCG 932
Score = 65.9 bits (159), Expect = 2e-10
Identities = 165/852 (19%), Positives = 285/852 (33%), Gaps = 162/852 (19%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
+CG+P IL G + + T +G IRYSC + L G L CI +WD PAP
Sbjct: 144 TCGNPGEILKGVL--HGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPF 201
Query: 82 CE--------YFNKYSSCPEPIVPGGYKIRGSTPY----RHGDSVTFACKTNFSMNGN-- 127
C SS P P Y+ + GD++ T+F +
Sbjct: 202 CRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVF-TDFQLEEGYD 260
Query: 128 ---------KSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLS 178
S+W N+ P + L + +H + +
Sbjct: 261 FLEISGTEAPSIWLTGMNLPSPV-------ISSKNWLRLHFTSDSNHRRKGFNAQFQVKK 313
Query: 179 VTYSCESGYLLV----GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRV 234
G ++ G + LS G + V C + G NG+ RV
Sbjct: 314 AIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDP-----GIPENGRRAGSDFSRV 368
Query: 235 GVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCEEIFCPS----PPPILNGRHI 288
G F C++ Y LQG S C + AW+ P+C C S P ++ +
Sbjct: 369 GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNY 428
Query: 289 GNSLANVSYGSIVTYTCDPDP-----------EEGVNFILIGE----------------S 321
+ ++ V T DPD E G + + +G+ S
Sbjct: 429 PVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGS 488
Query: 322 TLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRM------VSGQK--DRYTYND 373
++ + S W + + + + +I +G G++ + + D
Sbjct: 489 SVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGD 548
Query: 374 TVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC-----QAPPNILNGQKEDRH--- 425
T+ F C F L G + I C W + P C C + IL+ + +
Sbjct: 549 TLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNN 608
Query: 426 -----MVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT 480
++ +PG+ I N V + + +G+ + + QL +
Sbjct: 609 MNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGI--SDITVLGTFSGNEVPSQLAS 666
Query: 481 KPQHQFVRPDV---NSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA 537
VR + +S+ G G+ ++ + + + + C P + NG
Sbjct: 667 --SGHIVRLEFQSDHSTTGRGFNITYTTFGQNE----------------CHDPGIPINGR 708
Query: 538 HTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSL 597
G + F G++V++ C+ G G +I C D WS P C+
Sbjct: 709 RFG---DRFLLGSSVSFHCDDG-----FVKTQGSESITCILQD-GNVVWSSTVPRCE--- 756
Query: 598 LAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC 657
C A+ I P +Y D++ C K I+ D + E+
Sbjct: 757 --APCGGHLTASSGVILPPGWPGYYKDSL--HCEWIIEAKPGHSIKITFDR-FQTEV--- 808
Query: 658 EKETCQHVRQSLQELPAGSRV---ELVNTSCQDGYQLTGHAYQMCQDAENG-------IW 707
+ +++ PA S E T TG+ + +N I
Sbjct: 809 -----NYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIH 863
Query: 708 FKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSK 767
++ + L + C P + VNG G +F + V++ CD G+ L ++ L C + +
Sbjct: 864 YESVTL-ESDSCLDPGIPVNGHRHG---GDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQ 919
Query: 768 GHGSWSGPSPQC 779
W+ P C
Sbjct: 920 ----WNHALPSC 927
Score = 53.1 bits (126), Expect = 1e-06
Identities = 102/440 (23%), Positives = 171/440 (38%), Gaps = 76/440 (17%)
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEG--VWTPPVPQCKVAACEAT---GRQLLTKPQ 483
F G S+ +SC GY L G + C G VW+ P+P+C VA C A+ L P
Sbjct: 1062 FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC-VAECGASVKGNEGTLLSPN 1120
Query: 484 --------HQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYN 535
H+ + + + G+G L +Q +G +++ K+ + P
Sbjct: 1121 FPSNYDNNHECIYK-IETEAGKGIHLRTRSFQLFEGDT---LKVYDGKDSSSRPL----- 1171
Query: 536 GAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL 595
G T + L G + T N +EF+ G +D ++G L
Sbjct: 1172 GTFTKNEL----LGLILNSTSN---HLWLEFNTNG--------SDTDQGF-----QLTYT 1211
Query: 596 SLLAVQCSHVHIAN-GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN--TWDP 652
S V+C I N GY+I ++ +F + V + C G+ + GS+ + C + + WD
Sbjct: 1212 SFDLVKCEDPGIPNYGYRI--RDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDK 1269
Query: 653 EIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
+P C + + ++ A + +++ Y H + +A+ G K I
Sbjct: 1270 PLPSC-------IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWII-EADPG---KTIS 1318
Query: 713 LCKVIH----CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKG 768
L ++ H + +G + G+ + + F L + DS
Sbjct: 1319 LHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTF-----NSLTLQFDSDF 1373
Query: 769 HGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRV 827
S SG S Q S T C +P + ++G + + A D V C+PG+ + G
Sbjct: 1374 FISKSGFSIQFSTSIAAT-CNDPGMPQNGTRYGDSREA---GDTVTFQCDPGYQLQGQAK 1429
Query: 828 IRCHTDNT---WVPGVPTCI 844
I C N W P PTCI
Sbjct: 1430 ITCVQLNNRFFWQPDPPTCI 1449
Score = 52.0 bits (123), Expect = 3e-06
Identities = 179/829 (21%), Positives = 280/829 (33%), Gaps = 214/829 (25%)
Query: 91 CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSV-----------W------CQ 133
CP+P +P + GS R G +V F+C+ N+ + G+KS+ W C+
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Query: 134 A----NNMWGPTRLPT-------------CVSVFPLECPALPM--------IHNGHHT-- 166
A +N+ GP+ + T CV V P + + G+ T
Sbjct: 409 ARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLT 468
Query: 167 ---------SENV-----GSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEE 212
+ +V GS P L V+ S + L + + + S + AV E+
Sbjct: 469 VGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSD---DSIGSPGFKAVYQEIEK 525
Query: 213 ARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVC 271
C G GK L G T F C + L G R + Q W+ P C
Sbjct: 526 GGCGDPGIPAYGKRTGSSFLH-GDTLTFECPAAFELVG---ERVITCQQNNQWSGNKPSC 581
Query: 272 EEI----FCPSPPPILNGRH---IGNSLANV-----SYGSIVTYTC-DPDPEEGVNFILI 318
F S IL+ + GN++ V GS + D D E +F+ +
Sbjct: 582 VFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641
Query: 319 GESTLRCTVDSQKTGTWSGPAPRCELSTSA------VQCPHPQILRGRMVS----GQK-- 366
+ + D GT+SG +L++S Q H RG ++ GQ
Sbjct: 642 KDDGIS---DITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNEC 698
Query: 367 -------------DRYTYNDTVIFACMFGFT-LKGSKQIRCNAQG---TWEPSAPVCEKE 409
DR+ +V F C GF +GS+ I C Q W + P CE
Sbjct: 699 HDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAP 758
Query: 410 CQA----------PPNILNGQKEDRH---MVRFDPGTSIKYSCNPGYVLVGEESIQCTSE 456
C PP K+ H ++ PG SIK + + V ++++
Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818
Query: 457 GVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWF 516
+ P L H P S G L + + +I +
Sbjct: 819 PASSSP----------------LIGEYHGTQAPQFLISTGNFMYLLFTT-DNSRSSIGFL 861
Query: 517 M--EIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
+ E + +C P + NG G DF +TVT++C+PG ++L + +
Sbjct: 862 IHYESVTLESDSCLDPGIPVNGHRHGG---DFGIRSTVTFSCDPG------YTLSDDEPL 912
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEA-------PYFY----N 623
C N Q W+ P C + GY I GK P FY N
Sbjct: 913 VCERNHQ----WNHALPSCDA-----------LCGGY-IQGKSGTVLSPGFPDFYPNSLN 956
Query: 624 DTVTFKCYSG---------FTLKGSSQ-IRCKADNTWDPEIPVCEKETCQHVRQS--LQE 671
T T + G F L+ S + D ++ + H ++
Sbjct: 957 CTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGN 1016
Query: 672 LPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHT 731
A R + +G+ +T Y + C P V +
Sbjct: 1017 FTAQLRFISDFSISYEGFNITFSEYDLEP------------------CDDPGVPAFSRRI 1058
Query: 732 GMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
G +F G+ +++ C G+ L G KL C G WS P P+C+
Sbjct: 1059 GF---HFGVGDSLTFSCFLGYRLEGATKLTCLGG--GRRVWSAPLPRCV 1102
Score = 49.7 bits (117), Expect = 1e-05
Identities = 138/642 (21%), Positives = 214/642 (33%), Gaps = 126/642 (19%)
Query: 85 FNKYS--SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN--MWGP 140
F++Y C +P VP + R + GDS+TF+C + + G + C +W
Sbjct: 1038 FSEYDLEPCDDPGVPA-FSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSA 1096
Query: 141 TRLPTCVSVF---------PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
LP CV+ L P P ++ +H G + S L G
Sbjct: 1097 P-LPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG 1155
Query: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNG--------------------------- 224
+ + + GK S+ P + + LG N
Sbjct: 1156 DTLK--VYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSF 1213
Query: 225 ---KVKEPPILRVGVTAN-----------FFCDEGYRLQGPPSSRCVIAGQGVAWTK-MP 269
K ++P I G + C+ GY + G + C ++G W K +P
Sbjct: 1214 DLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTC-LSGDRRVWDKPLP 1272
Query: 270 VCEEIFCPSPPPILNGRHIGNSL-ANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328
C +GR + A T+ + DP + ++ I T D
Sbjct: 1273 SCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDT-EMAHD 1331
Query: 329 SQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGS 388
K W GP L P+ + S D+ F GF+++ S
Sbjct: 1332 ILKV--WDGPVDSDILLKEWSGSALPEDIHSTFNS----LTLQFDSDFFISKSGFSIQFS 1385
Query: 389 KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGE 448
I +P P Q R+ + G ++ + C+PGY L G+
Sbjct: 1386 TSIAATCN---DPGMP---------------QNGTRYGDSREAGDTVTFQCDPGYQLQGQ 1427
Query: 449 ESIQC---TSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSV 505
I C + W P P C +AAC LT P + P+ G
Sbjct: 1428 AKITCVQLNNRFFWQPDPPTC-IAACGGN----LTGPAGVILSPNYPQPYPPG------- 1475
Query: 506 YQECQGTI---PWFMEIRLCKEITCPPP---PVIYNGAHTGSSLEDFPYGTTVTYTCNPG 559
+EC + P F+ + K P IY G + S L +Y +
Sbjct: 1476 -KECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPL-------IGSYQGSQA 1527
Query: 560 PERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP 619
PER +E S G S +D G SG A K +I NG ++
Sbjct: 1528 PER-IESS--GNSLFLAFRSDASVGL-SGFAIEFKEKPREACFDPGNIMNGTRVG---TD 1580
Query: 620 YFYNDTVTFKCYSGFTLKGSSQIRC--KADN--TWDPEIPVC 657
+ T+T++C SG+ + S I C AD +WD +P C
Sbjct: 1581 FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 39.7 bits (91), Expect = 0.015
Identities = 52/230 (22%), Positives = 86/230 (37%), Gaps = 28/230 (12%)
Query: 45 TVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC--EYFNK-YSSCPEPIVPGGYK 101
TV+ YSC+ + + G +L C++ D+ WDKP P C E + +++ I+ GY
Sbjct: 1239 TVVLYSCNPGYAMHGSNTLTCLSGDR--RVWDKPLPSCIAECGGQIHAATSGRILSPGY- 1295
Query: 102 IRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVF--PLECPALPM 159
PY + C + K++ ++ + V+ P++ L
Sbjct: 1296 ---PAPYDN----NLHCTWIIEADPGKTISLHF-IVFDTEMAHDILKVWDGPVDSDILLK 1347
Query: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219
+G E++ S L++ + + +S +S T A C G
Sbjct: 1348 EWSGSALPEDIHSTFNSLTLQFDSDF-----------FISKSGFSIQFSTSIAATCNDPG 1396
Query: 220 RFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP 269
NG + G T F CD GY+LQG CV W P
Sbjct: 1397 MPQNG-TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDP 1445
Score = 36.2 bits (82), Expect = 0.16
Identities = 90/442 (20%), Positives = 149/442 (33%), Gaps = 80/442 (18%)
Query: 487 VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDF 546
+R V SC GY LS C+ W + C + C +G DF
Sbjct: 892 IRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL-CGGYIQGKSGTVLSPGFPDF 950
Query: 547 -PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQ----ERGTWSGPAPLCKLSLLAVQ 601
P T+T +GV+ +I + +S+D E G++S P S+L
Sbjct: 951 YPNSLNCTWTIEVSHGKGVQ--MIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLP-- 1006
Query: 602 CSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKET 661
H A + + + + +++ Y GF + S D DP +P +
Sbjct: 1007 --HTIKAGLFGNFTAQLRFISDFSIS---YEGFNITFSEYDLEPCD---DPGVPAFSRRI 1058
Query: 662 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP 721
H + + SC GY+L G C +W +P C V C
Sbjct: 1059 GFHFGVG----------DSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC-VAECGA 1107
Query: 722 PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDS------------KGH 769
V G +++ NF + ++EC K + R+ S G
Sbjct: 1108 S---VKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGK 1164
Query: 770 GSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR--V 827
S S P ++ + N H + T+ + D + GF + + +
Sbjct: 1165 DSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGS---------DTDQGFQLTYTSFDL 1215
Query: 828 IRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV 887
++C PG+P N + + F+ + +LYSC+ GY +
Sbjct: 1216 VKCED-----PGIP-----------------NYGYRIRDEGHFTDTV-VLYSCNPGYAMH 1252
Query: 888 GEALLLCT--HEGTWSQPAPHC 907
G L C W +P P C
Sbjct: 1253 GSNTLTCLSGDRRVWDKPLPSC 1274
Score = 31.6 bits (70), Expect = 4.0
Identities = 17/73 (23%), Positives = 29/73 (39%), Gaps = 2/73 (2%)
Query: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69
F+ P C S P GR + + G+++R+ C+ + L G +L C +
Sbjct: 1729 FVYQAVPRTSDTQCSSVPEPRYGR--RIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVP 1786
Query: 70 KVDGTWDKPAPKC 82
W+ P C
Sbjct: 1787 NALAQWNDTIPSC 1799
Score = 30.4 bits (67), Expect = 9.0
Identities = 17/60 (28%), Positives = 23/60 (38%), Gaps = 6/60 (10%)
Query: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT---WSQPAPHC 907
C P NG G + G ++ + CD GY L G+A + C W P C
Sbjct: 1392 CNDPGMPQNGTRYGDSR---EAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 315 bits (806), Expect = 2e-85
Identities = 257/918 (27%), Positives = 392/918 (42%), Gaps = 116/918 (12%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C +P +G I T + +V+R++C FRL+G+ S +C WD P P C
Sbjct: 2465 CSTPESPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2523
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK--SVWCQANNMW-G 139
+ SC P P I +T Y G VT+ C + ++ + + CQ++ W
Sbjct: 2524 QAI----SCGIPKAPTNGGIL-TTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSN 2578
Query: 140 PTRLPTCVSVFPLECPALPMIHNGHH--TSENVGSIAPGLSVTYSCESGYLLVGEKIINC 197
+ P CV + C LP NG+ T + GS A ++C+ G++LVG + C
Sbjct: 2579 HNKTPRCVVI---SCGELPTPPNGNKIGTQTSYGSTA-----IFTCDLGFMLVGSAVREC 2630
Query: 198 LSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV------TANFFCDEGYRLQGP 251
LSSG WS C C NG+V +G T + C+ G+RL G
Sbjct: 2631 LSSGLWSESETRCLAGHCGIPELIVNGQV-------IGENYGYRDTVVYQCNPGFRLIG- 2682
Query: 252 PSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
S I Q W+ ++P C + C P + GR GN ++ +VT++C+
Sbjct: 2683 --SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGF---NFNDVVTFSCN---- 2733
Query: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRG--RMVSGQKDR 368
+ +++ G + +C + Q WS P P C++ V C P I R +
Sbjct: 2734 --IGYLMQGPTKAQCQANRQ----WSHPPPMCKV----VNCSDPGIPANSKRESKIEHGN 2783
Query: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-EC---QAPPN-ILNGQKED 423
+TY V + C G+ L GS + C G W+ P C +C PPN +L+G+K
Sbjct: 2784 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-- 2841
Query: 424 RHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLL---- 479
+ G+++ YSC L+G+ S C G W+ P C A G
Sbjct: 2842 -----YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG 2896
Query: 480 TKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAH 538
++ + F + V +C GY L GS + C W CK + C P NG
Sbjct: 2897 SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANG-- 2954
Query: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLL 598
++ + ++V Y+C G + L G S +CT+N GTWSG P C +
Sbjct: 2955 KVFRIDGTTFSSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLPNCTI--- 3001
Query: 599 AVQCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYSGFT--LKGSSQIRCKADNTWDPEIP 655
+ C I ANG + Y V++ C G+T L GS C + TW +P
Sbjct: 3002 -ISCGDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP 3057
Query: 656 VCEKETCQHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
C TC Q G+ + ++ C GY+L+ A C NG W ++P
Sbjct: 3058 TCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTC--VGNGTWSGEVP 3115
Query: 713 LCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSW 772
C C P + GK G ++F+Y +EVS+ C+ F L+G C++D G+W
Sbjct: 3116 QCLPKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQAD----GTW 3168
Query: 773 SGPSPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCH 831
SG SP C+ P T C NP V +HG + N + +V C G ++ GS C
Sbjct: 3169 SGSSPHCI-EPTQTSCENPGVPRHGSQNNT--FGFQVGSVVQFHCKKGHLLQGSTTRTCL 3225
Query: 832 TDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV-GEA 890
D TW P CI + C P + N G ++ S G +++Y+C G+ L G
Sbjct: 3226 PDLTWSGIQPECIPHS---CKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTE 3280
Query: 891 LLLCTHEGTWSQPAPHCK 908
+C + TW+ P C+
Sbjct: 3281 HRVCRSDNTWTGKVPICE 3298
Score = 308 bits (788), Expect = 2e-83
Identities = 269/927 (29%), Positives = 387/927 (41%), Gaps = 107/927 (11%)
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
+K + Y Y S PE P GY I T + V +AC F + G S C+ +
Sbjct: 2452 NKKGFRIRYIAFYCSTPES-PPHGYII-SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2509
Query: 136 NM----WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
+ W +P C ++ P P + G T++ + G VTY C GY L
Sbjct: 2510 SYGYHAWDAP-VPACQAI-SCGIPKAPT-NGGILTTDYL----VGTRVTYFCNDGYRLSS 2562
Query: 192 EKIIN--CLSSGKWSA--VPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYR 247
+++ C S G WS P C C L PNG K G TA F CD G+
Sbjct: 2563 KELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFM 2621
Query: 248 LQGPPSSRCVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCD 306
L G C+ +G W++ C C P I+NG+ IG N Y V Y C+
Sbjct: 2622 LVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQVIGE---NYGYRDTVVYQCN 2675
Query: 307 PDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK 366
P F LIG S C Q+ WSG P C V C HP G + G+
Sbjct: 2676 P------GFRLIGSSVRIC----QQDHNWSGQLPSCV----PVSCGHP----GSPIYGRT 2717
Query: 367 --DRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKED 423
+ + +ND V F+C G+ ++G + +C A W P+C+ C P N ++E
Sbjct: 2718 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRES 2777
Query: 424 R-HMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLL 479
+ F GT + Y CNPGY L G + C G W P+P+C + C G +L
Sbjct: 2778 KIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL 2837
Query: 480 TKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI---TCPPPPVIYNG 536
+ ++ F V+ SC L G + CQ W C TC P +G
Sbjct: 2838 SGEKYTF-GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG 2896
Query: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
+ S+ F +TV Y C+ G + L G C +N G+W+G P CK
Sbjct: 2897 SRQESN---FRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECK-- 2941
Query: 597 LLAVQCSHVHI-ANG--YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPE 653
AVQC + ANG ++I G ++ +V + C G+ L G S +C A+ TW
Sbjct: 2942 --AVQCGNPGTTANGKVFRIDGTT----FSSSVIYSCMEGYILSGPSVRQCTANGTWSGT 2995
Query: 654 IPVCEKETCQHVRQSLQELPAGSRVEL---VNTSCQDGY--QLTGHAYQMCQDAENGIWF 708
+P C +C L G + V+ CQ GY +L G + C NG W
Sbjct: 2996 LPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTC--TINGTWS 3053
Query: 709 KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKG 768
+P C+ + C PP I NG+ G NF +G +SY C G+ L L C G
Sbjct: 3054 GVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYICSPGYELSFPAVLTC----VG 3106
Query: 769 HGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVI 828
+G+WSG PQCL C +P + K + ++ + V CN FI+ GS
Sbjct: 3107 NGTWSGEVPQCLPK----FCGDPGIPAQGK--REGKSFIYQSEVSFSCNFPFILVGSSTR 3160
Query: 829 RCHTDNTWVPGVPTCIKKAFIGCPPP--PKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886
C D TW P CI+ C P P+ + N+T G F G + + C +G+LL
Sbjct: 3161 ICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKGHLL 3216
Query: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946
G C + TWS P C +C P + + +G + C+ G+
Sbjct: 3217 QGSTTRTCLPDLTWSGIQPECIPHSCKQPE--TPAHANVVGMDLPSHGYTLIYTCQPGFF 3274
Query: 947 LEGSPQSQ-CQSDHQWNPPLAVCRSRS 972
L G + + C+SD+ W + +C + S
Sbjct: 3275 LAGGTEHRVCRSDNTWTGKVPICEAGS 3301
Score = 264 bits (675), Expect = 3e-70
Identities = 232/790 (29%), Positives = 335/790 (42%), Gaps = 101/790 (12%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P + ISCG P NG + T + G+ ++C F L+G C++ G W
Sbjct: 2583 PRCVVISCGELPTPPNG--NKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS----GLW 2636
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
+ +C + PE IV G ++ G Y + D+V + C F + G+ CQ +
Sbjct: 2637 SESETRC--LAGHCGIPELIVNG--QVIGEN-YGYRDTVVYQCNPGFRLIGSSVRICQQD 2691
Query: 136 NMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
+ W +LP+CV P+ C P P+ N + VT+SC GYL+ G
Sbjct: 2692 HNWSG-QLPSCV---PVSCGHPGSPIYGRTSGNGFNFNDV-----VTFSCNIGYLMQGPT 2742
Query: 194 IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVK---EPPILRVGVTANFFCDEGYRLQG 250
C ++ +WS PP C+ C G N K + E G + C+ GY L G
Sbjct: 2743 KAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFG 2802
Query: 251 PPSSRCVIAGQGVAWTK-MPVCEEIFC--PSPPP--ILNGRHIGNSLANVSYGSIVTYTC 305
C GQ W K +P C I C P PP +L+G ++GS V Y+C
Sbjct: 2803 SSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSGE-------KYTFGSTVHYSC 2852
Query: 306 DPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQ 365
L+G+S+ C Q G WSG P C + C P S Q
Sbjct: 2853 TGKRS------LLGQSSRTC----QLNGHWSGSQPHCSGDATGT-CGDPG--TPGHGSRQ 2899
Query: 366 KDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDR 424
+ + TV +AC G+ L GS++ C A G+W P C+ +C P NG+
Sbjct: 2900 ESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGK---- 2955
Query: 425 HMVRFDPGT---SIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG--RQLL 479
+ R D T S+ YSC GY+L G QCT+ G W+ +P C + +C G L
Sbjct: 2956 -VFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGL 3014
Query: 480 TKPQHQFVRPDVNSSCGEGY--KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA 537
V +V+ C GY +L+GS + C W + C+ +TCP PP I NG
Sbjct: 3015 RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGR 3074
Query: 538 HTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSL 597
G+ +F +G +++Y C+PG + L + + C N GTWSG P C
Sbjct: 3075 LEGT---NFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQC---- 3117
Query: 598 LAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC 657
L C I K GK + Y V+F C F L GSS C+AD TW P C
Sbjct: 3118 LPKFCGDPGIPAQGKREGKS--FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHC 3175
Query: 658 EKET---CQH---VRQSLQELPAGSRV-ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKK 710
+ T C++ R Q G +V +V C+ G+ L G + C + W
Sbjct: 3176 IEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTC--LPDLTWSGI 3233
Query: 711 IPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ-CRSDSKGH 769
P C C P + GM + +G + Y C GF+L G + + CRSD+
Sbjct: 3234 QPECIPHSCKQPETPAHANVVGMDLPS--HGYTLIYTCQPGFFLAGGTEHRVCRSDN--- 3288
Query: 770 GSWSGPSPQC 779
+W+G P C
Sbjct: 3289 -TWTGKVPIC 3297
Score = 179 bits (453), Expect = 2e-44
Identities = 136/506 (26%), Positives = 210/506 (41%), Gaps = 64/506 (12%)
Query: 491 VNSSCGEGYKLSGSVYQECQ----GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDF 546
V +C G++L G C+ G W + C+ I+C P NG G D+
Sbjct: 2488 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDY 2544
Query: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSG--PAPLCKLSLLAVQCSH 604
GT VTY CN G S +T C S+ GTWS P C + + C
Sbjct: 2545 LVGTRVTYFCNDG----YRLSSKELTTAVCQSD----GTWSNHNKTPRC----VVISCGE 2592
Query: 605 VHIA-NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ 663
+ NG KI + + Y T F C GF L GS+ C + W C C
Sbjct: 2593 LPTPPNGNKIGTQTS---YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHC- 2648
Query: 664 HVRQSLQELPAGSRV--------ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCK 715
+ EL +V + V C G++L G + ++CQ N W ++P C
Sbjct: 2649 ----GIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHN--WSGQLPSCV 2702
Query: 716 VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGP 775
+ C P + G+ +G F + + V++ C+ G+ + G K QC+++ + WS P
Sbjct: 2703 PVSCGHPGSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ----WSHP 2755
Query: 776 SPQCLRSPPVTRCPNPEVKHGYKLNKT--HSAYSHNDIVYVDCNPGFIMNGSRVIRCHTD 833
P C V C +P + K H +++ +V+ DCNPG+ + GS V+ C +
Sbjct: 2756 PPMC----KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN 2811
Query: 834 NTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLL 893
W +P CI I C P PN +G +++ G ++ YSC L+G++
Sbjct: 2812 GQWDKPLPECI---MIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCTGKRSLLGQSSRT 2865
Query: 894 CTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS 953
C G WS PHC + D G ++ + V C+ GY+L GS +
Sbjct: 2866 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEER 2925
Query: 954 QCQSDHQWNPPLAVCRSRSLAPVLCG 979
C ++ W C++ V CG
Sbjct: 2926 TCLANGSWTGRQPECKA-----VQCG 2946
Score = 142 bits (359), Expect = 1e-33
Identities = 239/1050 (22%), Positives = 371/1050 (35%), Gaps = 183/1050 (17%)
Query: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69
F+ P C S P GR AVG+ + + C+ + L G ++ C T
Sbjct: 1761 FVYQAVPRTSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1818
Query: 70 KVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS 129
W+ P C IVP G G R G ++ + N N
Sbjct: 1819 NSLAQWNDSLPTC------------IVPCG----GILTKRKGTILSPGYPEPYDNNLN-C 1861
Query: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTY---SCESG 186
VW ++ +L G + + +GS + G ++ + S +
Sbjct: 1862 VWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYS-GTTIPHLLNSTSNN 1920
Query: 187 YLLVGEKIINCLSSG---KWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFC 242
L + I+ ++G +++A+ +C E + S G +K VG +F C
Sbjct: 1921 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG------IKIGDRYMVGDVVSFQC 1974
Query: 243 DEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI- 300
D+GY LQG C+ G W +P+C C +G + S+
Sbjct: 1975 DQGYSLQGHSHITCM-PGPVRRWNYPIPICLAQ-CGGAMSDFSGVILSPGFPGNYPSSLD 2032
Query: 301 VTYTCDPDPEEGVNFILIGEST------LRCTVDSQKTGT----WSGPA-PRCELSTS-- 347
T+T + GV+ + ST L S +T T SGP P ST+
Sbjct: 2033 CTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHE 2092
Query: 348 ------------------------AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGF 383
CP P+ R V G +T T+ F C G+
Sbjct: 2093 TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND--FTVGQTISFECFPGY 2150
Query: 384 TLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441
TL G+ + C W P CE C +NG + PG +Y P
Sbjct: 2151 TLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNG-------TIYSPGYPDEY---P 2200
Query: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDVNS-SCG 496
+ + W VP T L T+P + F+ PD NS G
Sbjct: 2201 NF-----------QDCFWLVRVPPGNGIYINFT--VLQTEPIYDFITVWDGPDQNSPQIG 2247
Query: 497 E--GYKLSGSVYQECQGTIPWF----------------MEIRLCKEITCPPPPVIYNGAH 538
+ G SVY + F ++R+C+ PPPPV A
Sbjct: 2248 QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQ----PPPPV--PNAE 2301
Query: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL--- 595
+ ++F G + Y C PG F+L+G + + C ER G P+C++
Sbjct: 2302 ILTEDDEFEIGDIIRYQCLPG------FTLVGNAILTCRLG--ERLQMDGAPPVCQVLCP 2353
Query: 596 -SLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
+ L + + V ++ GY S + +S KG + + E
Sbjct: 2354 ANELRLDSTGVILSPGYPDS--------YPNLQMCAWSISVEKGYNITMFVEFFQTEKEF 2405
Query: 655 PVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
V + +++ + +G N + GH + A++G K +
Sbjct: 2406 DVLQVYDGPNIQSPVLISLSGDYSSAFNITS------NGHEVFLQWSADHGNNKKGFRIR 2459
Query: 715 KV-IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
+ +C P +G + V + CD+GF L+G+ CR S G+ +W
Sbjct: 2460 YIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2517
Query: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR--CH 831
P P C C P+ + T Y V CN G+ ++ + C
Sbjct: 2518 APVPAC----QAISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQ 2571
Query: 832 TDNTWV--PGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGE 889
+D TW P C+ I C P PNGN G + S G + +++CD G++LVG
Sbjct: 2572 SDGTWSNHNKTPRCV---VISCGELPTPPNGNKIG---TQTSYGSTAIFTCDLGFMLVGS 2625
Query: 890 ALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEG 949
A+ C G WS+ C +C P + I G + Y Y V +C G+ L G
Sbjct: 2626 AVRECLSSGLWSESETRCLAGHCGIP---ELIVNGQVIGENYGYRDTVVYQCNPGFRLIG 2682
Query: 950 SPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
S CQ DH W+ L C PV CG
Sbjct: 2683 SSVRICQQDHNWSGQLPSC-----VPVSCG 2707
Score = 99.0 bits (245), Expect = 2e-20
Identities = 78/276 (28%), Positives = 114/276 (41%), Gaps = 24/276 (8%)
Query: 14 VAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDG 73
V P ++C +PP I NGR+ T G I Y CS + L L C+ +G
Sbjct: 3055 VMPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVG----NG 3108
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
TW P+C K+ C +P +P K G + + + V+F+C F + G+ + CQ
Sbjct: 3109 TWSGEVPQC--LPKF--CGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILVGSSTRICQ 3163
Query: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
A+ W + P C+ C P +P H + N G V + C+ G+LL G
Sbjct: 3164 ADGTWSGSS-PHCIEPTQTSCENPGVPR----HGSQNNTFGFQVGSVVQFHCKKGHLLQG 3218
Query: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
CL WS + P C CK + V + G T + C G+ L G
Sbjct: 3219 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGG 3278
Query: 252 PSSRCVIAGQGVAWT-KMPVCE---EIFCPSPPPIL 283
R + WT K+P+CE +I P P L
Sbjct: 3279 TEHR--VCRSDNTWTGKVPICEAGSKILVKDPRPAL 3312
Score = 79.0 bits (193), Expect = 2e-14
Identities = 212/1013 (20%), Positives = 345/1013 (34%), Gaps = 220/1013 (21%)
Query: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149
SC +P +P + G + G +V+F+C + + ++ + + C+ N+ W LPTC ++
Sbjct: 905 SCLDPGIPVHGRRYGHD-FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP-LPTCDAL 962
Query: 150 F---------PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCES-------GYLLVGEK 193
+ P P + + G V ++ + YLL+ E
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1022
Query: 194 --IINCLSSGKWSAVPPTCE-------EARCKSLGRFPNG--------------KVKEPP 230
L+ S +PPT A+ + + F ++P
Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1082
Query: 231 ILR----------VGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC--------- 271
I + +G T F C GYRL+G C+ G+ V +P C
Sbjct: 1083 IPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASAT 1142
Query: 272 -EEIFCPSPPPILN-----------------GRHIGNSLANVSYGSIVTYTCDPDPEEGV 313
E SP LN G +I +++ G ++ D +
Sbjct: 1143 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHL 1202
Query: 314 NFILIGESTLRCTVDSQKTGTW-------SGPAPRCELSTSAVQCPH------PQILRGR 360
G S T+ S W G +L ++ + H PQ G
Sbjct: 1203 LGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GY 1260
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILN 418
+S Q + T+I+ C G+TL GS ++C + W+ P C EC
Sbjct: 1261 KISDQG--HFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG------ 1312
Query: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL 478
RF G S +PGY + +++C +W V + + +
Sbjct: 1313 ---------RFK-GESSGRILSPGYPFPYDNNLRC----MWMIEVDPGNIVSLQFLAFD- 1357
Query: 479 LTKPQHQFVR----PDVNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLCKE---- 524
T+ H +R P N + ++SGS+ E TI + + + K
Sbjct: 1358 -TEASHDILRVWDGPPENDMLLK--EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAI 1414
Query: 525 -------ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCT 577
C P V NG G E G TV + C+PG + L GE I C
Sbjct: 1415 QFSSSVATACRDPGVPMNGTRNGDGREP---GDTVVFQCDPG------YELQGEERITCI 1465
Query: 578 SNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYN-----------DT 625
+ R W P+C +A ++ ++G+ +S PY ++ D
Sbjct: 1466 QVEN-RYFWQPSPPVC----IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADY 1520
Query: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSC 685
V + F+++ + D D P+ S Q+ R+E + +
Sbjct: 1521 VISLAFISFSIEPNYDFLYIYDGP-DSNSPLIG---------SFQDSKLPERIESSSNTM 1570
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
++ G E ++ C P I+NG GM ++ G+ V+
Sbjct: 1571 HLAFRSDGSVSYTGFHLEYKAKLRE-------SCFDPGNIMNGTRLGM---DYKLGSTVT 1620
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE---VKHGYKLNKT 802
Y CD G+ L G L C G W+ P C +P +R E + Y N
Sbjct: 1621 YYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKN-- 1677
Query: 803 HSAYSHNDIVYVDCNPGFIMNGSRVI--RCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG 860
+ HN + + F++ G V D V PT + +G
Sbjct: 1678 -YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLL-------SSLSG 1729
Query: 861 NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMD 919
+H+G ++ S G I + VG H Q P CSS P
Sbjct: 1730 SHSGESLP-LSSGNQITIR----FTSVGPITAKGFH--FVYQAVPRTSSTQCSSVPEPRF 1782
Query: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ----SDHQWNPPLAVC 968
G + G E + G+ V +C GY+L GS +C+ S QWN L C
Sbjct: 1783 GRRIGNE----FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1831
Score = 68.6 bits (166), Expect = 3e-11
Identities = 170/817 (20%), Positives = 277/817 (33%), Gaps = 159/817 (19%)
Query: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-------------------- 82
+G + +SCS +RL G ++C+ + W P P+C
Sbjct: 1096 IGDTLTFSCSSGYRLEGTSEIICLGGGR--RVWSAPLPRCVAECGASATNNEGILLSPNY 1153
Query: 83 --EYFNKYSSCPEPIVPGGYKIRGSTPYRH---GDSV-----------TFACKTNFSMNG 126
Y N + V G I S H GD + T SM G
Sbjct: 1154 PLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRG 1213
Query: 127 ------NKSVWCQANNMW-----GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP 175
+ +W + N+ G + T + E P +P G+ S+ G A
Sbjct: 1214 LTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQ-GHFA- 1269
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233
G ++ Y C GY L G ++ C++ + W P+C A C GRF
Sbjct: 1270 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAECG--GRFK----------- 1315
Query: 234 VGVTANFFCDEGYRLQGPPSSRC----------VIAGQGVAWTKMPVCEEIFCPSPPPIL 283
G ++ GY + RC +++ Q +A+ + + PP
Sbjct: 1316 -GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP-- 1372
Query: 284 NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCE 343
+ L GS++ EG++ L + + D+ + SG A +
Sbjct: 1373 ----ENDMLLKEISGSLI--------PEGIHSTL---NIVTIQFDTDFYISKSGFAIQFS 1417
Query: 344 LSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWE 400
S+ A C P + +G D DTV+F C G+ L+G ++I C + W+
Sbjct: 1418 -SSVATACRDPGVPMNGTRNG--DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQ 1474
Query: 401 PSAPVCEKECQAPPNILNG---QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457
PS PVC C +G H + N YV+ S+ S
Sbjct: 1475 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI----SLAFISFS 1530
Query: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE---GYKLSGSVYQECQGTIP 514
+ P + + L+ Q + + SS ++ GSV
Sbjct: 1531 I-EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV-----SYTG 1584
Query: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574
+ +E + +C P I NG G D+ G+TVTY C+ G + L G ST+
Sbjct: 1585 FHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYSTL 1635
Query: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFK 629
C D R W+ P C H G + +G E Y N +V
Sbjct: 1636 TCIMGDDGRPGWNRALPSC------------HAPCGSRSTGSEGTVLSPNYPKNYSVGHN 1683
Query: 630 CYSGFTLKGSSQIRCK---ADNTWDPEIPVCEKETCQ-HVRQSLQELPAGSRVELVNTSC 685
C + + + + + V + T Q + SL +G + L
Sbjct: 1684 CVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPL----- 1738
Query: 686 QDGYQLTGHAYQMCQDAENGIWF--KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743
G Q+T + G F + +P C P G+ G F G+
Sbjct: 1739 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSS 1795
Query: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
V ++C+ G+ L G ++C + W+ P C+
Sbjct: 1796 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1832
Score = 62.8 bits (151), Expect = 2e-09
Identities = 102/447 (22%), Positives = 162/447 (36%), Gaps = 79/447 (17%)
Query: 233 RVGVTANFFCDEGYRLQGPPSSRCVIAGQG-VAWTK-MPVCEEIFCPSPPPILNGRHIG- 289
++G T ++CD GY LQG + C++ G W + +P C C S G +
Sbjct: 1614 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLSP 1672
Query: 290 NSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
N N S G Y+ E F++ G+ T + GP + L +S
Sbjct: 1673 NYPKNYSVGHNCVYSIAVPKE----FVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1728
Query: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE 409
+ L + SG + T+ F + T KG + ++ +
Sbjct: 1729 GSHSGESLP--LSSGNQI------TIRFTSVGPITAKGFHFV-------YQAVPRTSSTQ 1773
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQ 465
C + P G++ F G+S+ + CNPGY+L G +I+C S W +P
Sbjct: 1774 CSSVPEPRFGRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1830
Query: 466 CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525
C + C +LTK + + P Y E P+ + +I
Sbjct: 1831 C-IVPCGG----ILTKRKGTILSPG---------------YPE-----PYDNNLNCVWKI 1865
Query: 526 TCPP------PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579
T P V + H SL+ + G N P G + TSN
Sbjct: 1866 TVPEGAGIQVQVVSFATEHNWDSLDFYDGGD------NNAPRLGSYSGTTIPHLLNSTSN 1919
Query: 580 D---QERGTWSGPAPLCKLSLLAV---QCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYS 632
+ + S A L A+ C ++G KI + Y D V+F+C
Sbjct: 1920 NLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDR---YMVGDVVSFQCDQ 1976
Query: 633 GFTLKGSSQIRCKAD--NTWDPEIPVC 657
G++L+G S I C W+ IP+C
Sbjct: 1977 GYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Score = 60.1 bits (144), Expect = 1e-08
Identities = 186/922 (20%), Positives = 311/922 (33%), Gaps = 241/922 (26%)
Query: 89 SSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM----WGPTRLP 144
SSC P VP + G T + GD + ++C T + ++G+ + C AN++ W +P
Sbjct: 176 SSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASW-DFPVP 233
Query: 145 TC-----------VSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
C S + P+ P + H+ ++ +I T S + EK
Sbjct: 234 ICRAEDACGGTMRGSSGIISSPSFP--NEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK 291
Query: 194 IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPIL--RVGVTANFFCDEGYRLQG- 250
G + PPT + +G PPI+ + + +F D +R +G
Sbjct: 292 YDYLEIEG---SEPPTI----------WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGF 338
Query: 251 -----------------------PPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRH 287
S++ I +G T +C P P NG+
Sbjct: 339 SAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLC-----PDPGEPENGKR 393
Query: 288 IGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTS 347
IG ++ S GS V ++CD D ++L G ++ C ++ WS P C++ T
Sbjct: 394 IG---SDFSLGSTVQFSCDED------YVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444
Query: 348 AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE 407
G + G +T + F F Q NAQ W +A
Sbjct: 445 -----------GSNLQGPSGTFTSPN-------FPF------QYDSNAQCVWVITAVNTN 480
Query: 408 KECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCK 467
K Q +N ++ D + +G +++ G P +
Sbjct: 481 KVIQ-----INFEEFD--------------------LEIGYDTLTIGDGGEVGDPRTVLQ 515
Query: 468 VAACEATGRQLLTKPQHQFVRPDVNSSCGE-GYKLSGSVYQECQGTIPWFMEIRLCKEIT 526
V +++ ++ + S G G+K++ Y+E + KE +
Sbjct: 516 VLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN---YKEIE------------KE-S 559
Query: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
C P G G + F + + C G F LIGE +I C N+Q W
Sbjct: 560 CGDPGTPLYGIREG---DGFSNRDVLRFECQFG------FELIGEKSIVCQENNQ----W 606
Query: 587 SGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVT-------------FKCYSG 633
S P+C C A + + P Y + + ++
Sbjct: 607 SANIPIC-----IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND 661
Query: 634 FTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTG 693
F L+ D PE P+ T V L S ++ Q + ++G
Sbjct: 662 FDLESQFDFLAVKDGD-SPESPILGTFTGAEVPSHLT-----SNSHILRLEFQADHSMSG 715
Query: 694 HAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFY 753
+ + + C P + +N + G +NF G+ +S C++GF
Sbjct: 716 RGFNITYNTFGH-----------NECPDPGIPINARRFG---DNFQLGSSISVICEEGFI 761
Query: 754 -LLGEKKLQCRSDSKGHGSWSGPSPQCLR------SPPVTRCPNP--------------- 791
G + + C G WSG P+C S P +P
Sbjct: 762 KTQGTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWV 820
Query: 792 -EVKHGYKLNKTHSAYS---HNDIVYVDCNPGFI------MNGSRV------------IR 829
E + G+ + T + + D++ V P + NG++V +
Sbjct: 821 IEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLL 880
Query: 830 CHTDNTWV-PGVPTCIKKAFI---GCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYL 885
TDN+ G + + C P +G G + FS G ++ +SCD GY
Sbjct: 881 FTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYR 937
Query: 886 LVGEALLLCTHEGTWSQPAPHC 907
L E LLC WS P P C
Sbjct: 938 LSHEEPLLCEKNHWWSHPLPTC 959
Score = 52.4 bits (124), Expect = 2e-06
Identities = 123/519 (23%), Positives = 181/519 (34%), Gaps = 101/519 (19%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG+P G + Y T VG IRYSC + L G L CI +WD P P
Sbjct: 177 SCGNPGVPPKGVL--YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 82 CEYFNKYSS--------CPEPIVPGGYKIRGSTPY----RHGDSVTFACKTNFSMNGNKS 129
C + P P Y + GD+++ T+F M K
Sbjct: 235 CRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-TDFQME-EKY 292
Query: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGH----HTSENVGSIAPGLSVTYSCES 185
+ + PT + +++ P P+I N + H + G S Y +
Sbjct: 293 DYLEIEGSEPPTIWLSGMNIPP------PIISNKNWLRLHFVTDSNHRYRGFSAPYQVKK 346
Query: 186 -------GYLLVGEKIINCLSSGKWSAVPP---TCEEARCKSLGRFPNGKVKEPPILRVG 235
G+ L K +S K+S + C G NGK + +G
Sbjct: 347 AIDFKSRGFKLFPGKD----NSNKFSILNEGGIKTASNLCPDPGEPENGK-RIGSDFSLG 401
Query: 236 VTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSL- 292
T F CDE Y LQG S C IA AW+ PVC+ C S +G +
Sbjct: 402 STVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFP 461
Query: 293 ----ANVSYGSIVTYTCDPDPEEGVNF----ILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
+N ++T + + +NF + IG TL D + G PR L
Sbjct: 462 FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDTLTIG-DGGEVGD-----PRTVL 514
Query: 345 STSAVQCPHPQILRGRMV-------SGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQG 397
Q+L G V S Q + D + + F K ++ C G
Sbjct: 515 ----------QVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPG 564
Query: 398 TWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457
T P + E + +R ++RF+ C G+ L+GE+SI C
Sbjct: 565 T--PLYGIREGD----------GFSNRDVLRFE--------CQFGFELIGEKSIVCQENN 604
Query: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496
W+ +P C + C + T P + PD G
Sbjct: 605 QWSANIPIC-IFPCLSN----FTAPMGTVLSPDYPEGYG 638
Score = 47.0 bits (110), Expect = 9e-05
Identities = 101/501 (20%), Positives = 187/501 (37%), Gaps = 75/501 (14%)
Query: 343 ELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQG----T 398
EL +S+ C +P + ++ G R+ D + ++C+ G+ L G Q+ C A +
Sbjct: 172 ELQSSS--CGNPGVPPKGVLYGT--RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTAS 227
Query: 399 WEPSAPVC--EKECQAP-------------PNILNGQKEDRHMVRFDPGTSIK-----YS 438
W+ P+C E C PN + + + +PG +I +
Sbjct: 228 WDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQ 287
Query: 439 CNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQF--------VRPD 490
Y + E + + + +P ++ +T H++ V+
Sbjct: 288 MEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKA 347
Query: 491 VNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGT 550
++ G+KL + +I I+ + CP P NG GS DF G+
Sbjct: 348 IDFK-SRGFKLFPGKDNSNKFSILNEGGIKTASNL-CPDPGEPENGKRIGS---DFSLGS 402
Query: 551 TVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANG 610
TV ++C+ ++ L G +I C + WS P+CK+ S++ +G
Sbjct: 403 TVQFSCDE------DYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCG---SNLQGPSG 453
Query: 611 YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI-----PVCEKETCQHV 665
+ P+ Y+ +C T ++++ +D EI + +
Sbjct: 454 -TFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDP 510
Query: 666 RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVI 725
R LQ L GS V + S L + + +K+I + C P
Sbjct: 511 RTVLQVL-TGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI---EKESCGDPGTP 566
Query: 726 VNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL----- 780
+ G G + F + + +EC GF L+GEK + C+ +++ WS P C+
Sbjct: 567 LYGIREG---DGFSNRDVLRFECQFGFELIGEKSIVCQENNQ----WSANIPICIFPCLS 619
Query: 781 -RSPPVTRCPNPEVKHGYKLN 800
+ P+ +P+ GY N
Sbjct: 620 NFTAPMGTVLSPDYPEGYGNN 640
Score = 45.1 bits (105), Expect = 4e-04
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH----EGT 899
IK A CP P + NG G + FS G ++ +SCD+ Y+L G + C
Sbjct: 375 IKTASNLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 431
Query: 900 WSQPAPHCKEVNCSS 914
WS P CK C S
Sbjct: 432 WSDHRPVCKVKTCGS 446
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 34/252 (13%)
Query: 606 HIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT----WDPEIPVCEKET 661
+I NG ++ Y TVT+ C +G+ L+G S + C + W+ +P C
Sbjct: 1602 NIMNGTRLG---MDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC 1658
Query: 662 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGH--AYQMCQDAENGIWFKKIPLCKVIHC 719
GS +++ + Y + GH Y + E ++ + + +H
Sbjct: 1659 GSR--------STGSEGTVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLHD 1709
Query: 720 HPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--P 777
V + G ++ L + + L ++ R S G + G
Sbjct: 1710 ------VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1763
Query: 778 QCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT- 835
Q + T+C + PE + G ++ + S V DCNPG+I++GS IRC T
Sbjct: 1764 QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSS---VLFDCNPGYILHGSIAIRCETVPNS 1820
Query: 836 ---WVPGVPTCI 844
W +PTCI
Sbjct: 1821 LAQWNDSLPTCI 1832
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/262 (20%), Positives = 91/262 (34%), Gaps = 42/262 (16%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C P NGK G +F G+ V + CD+ + L G K + C+ ++ +WS P
Sbjct: 382 CPDPGEPENGKRIG---SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 438
Query: 779 C--------LRSPPVTRCPNPEVKHGYKLNK----THSAYSHNDIVYVDCNPGFIMNGSR 826
C L+ P T +P Y N +A + N ++ ++ + G
Sbjct: 439 CKVKTCGSNLQGPSGT-FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 497
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886
+ G P + + G P I S M + D+
Sbjct: 498 TLTIGDGGE--VGDPRTVLQVLTGSFVPDL----------IVSMSSQMWLHLQTDESVGS 545
Query: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946
VG + + KE+ S D G+ + V+ EC+ G+
Sbjct: 546 VGFKV--------------NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 591
Query: 947 LEGSPQSQCQSDHQWNPPLAVC 968
L G CQ ++QW+ + +C
Sbjct: 592 LIGEKSIVCQENNQWSANIPIC 613
Score = 38.9 bits (89), Expect = 0.025
Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 36/261 (13%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC P I+NG + +G+ + Y C + L G +L CI D W++ P
Sbjct: 1596 SCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653
Query: 82 CEYFNKYSSCPEPIVPGGYKIRG------STPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
C P G + G S Y SV C + ++ V+ Q
Sbjct: 1654 CH------------APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQF- 1700
Query: 136 NMWGPTRLPTCVSVF--PLECPALPMIHNGHHTSENVG-SIAPGLSVTYSCESGYLLVGE 192
++ T L V V+ P + +L +G H+ E++ S +++ ++ G
Sbjct: 1701 -VFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF 1759
Query: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPP 252
+ + AVP T +C S+ P + VG + F C+ GY L G
Sbjct: 1760 HFV-------YQAVPRT-SSTQCSSVPE-PRFGRRIGNEFAVGSSVLFDCNPGYILHGSI 1810
Query: 253 SSRCVIAGQGVA-WT-KMPVC 271
+ RC +A W +P C
Sbjct: 1811 AIRCETVPNSLAQWNDSLPTC 1831
Score = 35.8 bits (81), Expect = 0.21
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 7/62 (11%)
Query: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC----THEGTWSQPAPH 906
C P P G G RF G I YSC GY+L G L C + +W P P
Sbjct: 178 CGNPGVPPKGVLYG---TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 907 CK 908
C+
Sbjct: 235 CR 236
Score = 35.8 bits (81), Expect = 0.21
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC P ++GR Y ++G+ + +SC +RL E+ LLC + + W P P
Sbjct: 905 SCLDPGIPVHGR--RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC----EKNHWWSHPLPT 958
Query: 82 CE 83
C+
Sbjct: 959 CD 960
Score = 35.8 bits (81), Expect = 0.21
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 6/49 (12%)
Query: 931 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
+ G+ V+ C+ GY L C+ +H W+ PL C LCG
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC------DALCG 964
Score = 35.8 bits (81), Expect = 0.21
Identities = 56/279 (20%), Positives = 105/279 (37%), Gaps = 63/279 (22%)
Query: 85 FNKYS--SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC--QANNMWGP 140
F++Y+ C +P +P Y R + GD++TF+C + + + G + C +W
Sbjct: 1070 FSEYNLEPCEDPGIPQ-YGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWS- 1127
Query: 141 TRLPTCVSVFPLEC-------------PALPMIHNGHHTSENVGSIAPGLSVTYSCESGY 187
LP CV+ EC P P+ + +H + G + S + +
Sbjct: 1128 APLPRCVA----ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFH 1183
Query: 188 LLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYR 247
L G+ + + GK + LG F ++ G+T + ++ +
Sbjct: 1184 LAQGD--VLKIYDGK---------DKTTHLLGAFTGASMR-------GLTLSSTSNQLW- 1224
Query: 248 LQGPPSSRCVIAGQGVAWTKMPV--CEEIFCPSPPPILNGRHIGNSLANVSY--GSIVTY 303
L+ + G + +T + CE+ P G +++ + GS + Y
Sbjct: 1225 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP---------QFGYKISDQGHFAGSTIIY 1275
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC 342
C+P + L G S L+C ++ W P P C
Sbjct: 1276 GCNP------GYTLHGSSLLKCMTGERR--AWDYPLPSC 1306
Score = 33.1 bits (74), Expect = 1.4
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH----QWNP 963
+E+ SS + KG+ + G + C GY+L+G PQ C ++ W+
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 964 PLAVCRS 970
P+ +CR+
Sbjct: 231 PVPICRA 237
Score = 30.8 bits (68), Expect = 6.9
Identities = 15/64 (23%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 932 QYGAVVTLECEDGYMLEGSPQSQCQSD----HQWNPPLAVCRSRSLAPVLCGIAAGLILL 987
Q +VV C+ G+ L G + C+ H W+ P+ C++ S G++
Sbjct: 2483 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTT 2542
Query: 988 TFLI 991
+L+
Sbjct: 2543 DYLV 2546
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 256 bits (654), Expect = 8e-68
Identities = 231/872 (26%), Positives = 338/872 (38%), Gaps = 101/872 (11%)
Query: 72 DGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW 131
D +++ K Y Y S P + G I G T + G S+ F C + + G+
Sbjct: 2451 DHAYNRKGFKIRYSAPYCSLPRAPLHGF--ILGQTSTQPGGSIHFGCNAGYRLVGHSMAI 2508
Query: 132 C----QANNMWGPTRLPTC--VSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCES 185
C Q ++W +P C +S E P M+ +T G YSC
Sbjct: 2509 CTRHPQGYHLWSEA-IPLCQALSCGLPEAPKNGMVFGKEYTV--------GTKAMYSCSE 2559
Query: 186 GYLLVG--EKIINCLSSGKWSA--VPPTCEEARCKSLGRFPNGKVKEPPILRVGVTAN-- 239
GY L E CL +G WS VPP C C + + I
Sbjct: 2560 GYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQ 2619
Query: 240 --FFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSY 297
CD GY G RC G+ P C I C P NG IG Y
Sbjct: 2620 LMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSV---Y 2676
Query: 298 GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357
G+ ++C+ + L+G C + G WSG RC A C P+ +
Sbjct: 2677 GATAIFSCNS------GYTLVGSRVRECMAN----GLWSGSEVRC----LAGHCGTPEPI 2722
Query: 358 RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNI 416
++G+ Y+Y +V++ C GF L G C W P C C P +
Sbjct: 2723 VNGHINGEN--YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSP 2780
Query: 417 LNGQKE-DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG 475
+ Q D + V G ++YSC LVG + C +G WT +P C + G
Sbjct: 2781 PHSQMSGDSYTV----GAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCG 2836
Query: 476 RQLLTKPQHQFVRPD-------VNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCP 528
+ P H D + SC G+ L GS + CQ W C I+C
Sbjct: 2837 DPGI--PAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCG 2894
Query: 529 PPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSG 588
P N S + + +++ Y C G + G + C+ N GTW+G
Sbjct: 2895 NPGTPSNARVVFS--DGLVFSSSIVYECREG------YYATGLLSRHCSVN----GTWTG 2942
Query: 589 PAPLCKLSLLAVQCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGS--SQIRCK 645
P C L + C I ANG ++ + YN TVT++C G+ ++ S + C
Sbjct: 2943 SDPEC----LVINCGDPGIPANGLRLGND---FRYNKTVTYQCVPGYMMESHRVSVLSCT 2995
Query: 646 ADNTWDPEIPVCEKETCQHVRQSLQELPAGSRV---ELVNTSCQDGYQLTGHAYQMCQDA 702
D TW+ PVC+ C+ GS V +C +GYQL+ A C+
Sbjct: 2996 KDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEG- 3054
Query: 703 ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762
NG W ++P C + C P V G+ F Y + VS+ C L+G + C
Sbjct: 3055 -NGSWTGELPQCFPVFCGDPGVPSRGRRED---RGFSYRSSVSFSCHPPLVLVGSPRRFC 3110
Query: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIM 822
+SD G+WSG P C+ P +T C +P V + + Y V C G+++
Sbjct: 3111 QSD----GTWSGTQPSCI-DPTLTTCADPGVPQ-FGIQNNSQGYQVGSTVLFRCQKGYLL 3164
Query: 823 NGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQ 882
GS C + TW P C+ P+TP + G + S G +++YSC +
Sbjct: 3165 QGSTTRTCLPNLTWSGTPPDCVPHHC----RQPETPTHANVGA-LDLPSMGYTLIYSCQE 3219
Query: 883 GYLLVGEAL-LLCTHEGTWSQPAPHCKEVNCS 913
G+ L G + C +G+W+ P C EV S
Sbjct: 3220 GFSLKGGSEHRTCKADGSWTGKPPICLEVRPS 3251
Score = 255 bits (651), Expect = 2e-67
Identities = 218/826 (26%), Positives = 326/826 (39%), Gaps = 93/826 (11%)
Query: 172 SIAPGLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPPTCEEARCKSLGRFPNGKV- 226
S PG S+ + C +GY LVG + C + WS P C+ C NG V
Sbjct: 2484 STQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVF 2543
Query: 227 -KEPPILRVGVTANFFCDEGYRLQG--PPSSRCVIAGQGVAWTKMPVCEEIFCP--SPPP 281
KE VG A + C EGY LQ ++ C+ G P C + CP S
Sbjct: 2544 GKE---YTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSIS 2600
Query: 282 ILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWS--GPA 339
+ +GR + + + CDP + G+ +RC Q G WS
Sbjct: 2601 VEHGRWRLIFETQYQFQAQLMLICDP------GYYYTGQRVIRC----QANGKWSLGDST 2650
Query: 340 PRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTW 399
P C + S + P P G + Y T IF+C G+TL GS+ C A G W
Sbjct: 2651 PTCRI-ISCGELPIPP--NGHRIGTLS---VYGATAIFSCNSGYTLVGSRVRECMANGLW 2704
Query: 400 EPSAPVC-EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
S C C P I+NG + + S+ Y CN G+ L+G C +
Sbjct: 2705 SGSEVRCLAGHCGTPEPIVNGHINGEN---YSYRGSVVYQCNAGFRLIGMSVRICQQDHH 2761
Query: 459 WTPPVPQCKVAACEATGRQLLTKPQHQFVRPD-------VNSSCGEGYKLSGSVYQECQG 511
W+ P C + +C G P H + D V SC L G+ + C
Sbjct: 2762 WSGKTPFCVLVSCGHPG-----SPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGL 2816
Query: 512 TIPWFMEIRLCKEIT---CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568
W + C + C P + +G G S F GT + ++C G L
Sbjct: 2817 DGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDS---FDPGTVMRFSCEAG------HVL 2867
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTF 628
G S C +N G+WSG P C + + C + + ++ + F + ++ +
Sbjct: 2868 RGSSERTCQAN----GSWSGSQPECGV----ISCGNPGTPSNARVVFSDGLVF-SSSIVY 2918
Query: 629 KCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRV---ELVNTSC 685
+C G+ G C + TW P C C L G+ + V C
Sbjct: 2919 ECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQC 2978
Query: 686 QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745
GY + H + ++ W P+CK + C PPP+I NGK G +F++G+ V+
Sbjct: 2979 VPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVG---SDFMWGSSVT 3035
Query: 746 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSA 805
Y C +G+ L C +G+GSW+G PQC PV C +P V + +
Sbjct: 3036 YACLEGYQLSLPAVFTC----EGNGSWTGELPQCF---PVF-CGDPGVPS--RGRREDRG 3085
Query: 806 YSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPP--PKTPNGNHT 863
+S+ V C+P ++ GS C +D TW P+CI C P P+ N++
Sbjct: 3086 FSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNS 3145
Query: 864 GGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQK 923
G + G ++L+ C +GYLL G C TWS P C +C P
Sbjct: 3146 QG----YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANV 3201
Query: 924 GLEPRKMYQYGAVVTLECEDGYMLE-GSPQSQCQSDHQWNPPLAVC 968
G + G + C++G+ L+ GS C++D W +C
Sbjct: 3202 G--ALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPIC 3245
Score = 254 bits (649), Expect = 3e-67
Identities = 230/856 (26%), Positives = 326/856 (38%), Gaps = 95/856 (11%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C P L+G I T G I + C+ +RL+G +C + W + P C
Sbjct: 2468 CSLPRAPLHGFI-LGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC 2526
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGP 140
+ SC P P + G Y G ++C + + C +W
Sbjct: 2527 QAL----SCGLPEAPKNGMVFGKE-YTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSN 2581
Query: 141 TRLPT-CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYS--CESGYLLVGEKIINC 197
+P CV P+ CP + I H + C+ GY G+++I C
Sbjct: 2582 RNVPPQCV---PVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRC 2638
Query: 198 LSSGKWSA--VPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255
++GKWS PTC C L PNG + + G TA F C+ GY L G
Sbjct: 2639 QANGKWSLGDSTPTCRIISCGELPIPPNGH-RIGTLSVYGATAIFSCNSGYTLVGSRVRE 2697
Query: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C+ G W+ V C C +P PI+NG HI N SY V Y C+
Sbjct: 2698 CMANG---LWSGSEVRCLAGHCGTPEPIVNG-HINGE--NYSYRGSVVYQCN------AG 2745
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
F LIG S C D WSG P C L V C HP +SG D YT
Sbjct: 2746 FRLIGMSVRICQQDHH----WSGKTPFCVL----VSCGHPGSPPHSQMSG--DSYTVGAV 2795
Query: 375 VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVR----FD 430
V ++C+ TL G+ C G W S P C + H +R FD
Sbjct: 2796 VRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSG---TSVGVCGDPGIPAHGIRLGDSFD 2852
Query: 431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPD 490
PGT +++SC G+VL G C + G W+ P+C V +C G T + V D
Sbjct: 2853 PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPG----TPSNARVVFSD 2908
Query: 491 -------VNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL 543
+ C EGY +G + + C W C I C P + NG G+
Sbjct: 2909 GLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGN-- 2966
Query: 544 EDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCS 603
DF Y TVTY C P G S + CT + TW+G P+CK A+ C
Sbjct: 2967 -DFRYNKTVTYQCVP----GYMMESHRVSVLSCTKD----RTWNGTKPVCK----ALMCK 3013
Query: 604 HVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQ 663
+ K+ G + + + +VT+ C G+ L + C+ + +W E+P C C
Sbjct: 3014 PPPLIPNGKVVGSD--FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCG 3071
Query: 664 H---VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC---KVI 717
+ +E S V+ SC L G + CQ +G W P C +
Sbjct: 3072 DPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQ--SDGTWSGTQPSCIDPTLT 3129
Query: 718 HCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSP 777
C P V G ++ + G+ V + C +G+ L G C + +WSG P
Sbjct: 3130 TCADPGVPQFGIQNN--SQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNL----TWSGTPP 3183
Query: 778 QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR-CHTDNTW 836
C+ C PE + ++Y C GF + G R C D +W
Sbjct: 3184 DCVPH----HCRQPETPTHANVGALDLPSMGYTLIY-SCQEGFSLKGGSEHRTCKADGSW 3238
Query: 837 VPGVPTCIKKAFIGCP 852
P C++ G P
Sbjct: 3239 TGKPPICLEVRPSGRP 3254
Score = 181 bits (458), Expect = 4e-45
Identities = 163/600 (27%), Positives = 230/600 (38%), Gaps = 75/600 (12%)
Query: 402 SAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG---- 457
SAP C + GQ + PG SI + CN GY LVG CT
Sbjct: 2464 SAPYCSLPRAPLHGFILGQTSTQ------PGGSIHFGCNAGYRLVGHSMAICTRHPQGYH 2517
Query: 458 VWTPPVPQCKVAAC---EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQ--ECQGT 512
+W+ +P C+ +C EA ++ ++ V SC EGY L EC T
Sbjct: 2518 LWSEAIPLCQALSCGLPEAPKNGMVFGKEYT-VGTKAMYSCSEGYHLQAGAEATAECLDT 2576
Query: 513 IPWFMEI--RLCKEITCPPPPVIY--NGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568
W C +TCP I +G + + + C+PG +
Sbjct: 2577 GLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPG------YYY 2630
Query: 569 IGESTIRCTSNDQERGTWS--GPAPLCKLSLLAVQCSHVHIA-NGYKISGKEAPYFYNDT 625
G+ IRC +N G WS P C++ + C + I NG++I Y T
Sbjct: 2631 TGQRVIRCQAN----GKWSLGDSTPTCRI----ISCGELPIPPNGHRIGTLSV---YGAT 2679
Query: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVEL---VN 682
F C SG+TL GS C A+ W C C + G V
Sbjct: 2680 AIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVV 2739
Query: 683 TSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHC-HP--PPVIVNGKHTGMMAENFL 739
C G++L G + ++CQ + W K P C ++ C HP PP H+ M +++
Sbjct: 2740 YQCNAGFRLIGMSVRICQQDHH--WSGKTPFCVLVSCGHPGSPP------HSQMSGDSYT 2791
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVK-HGYK 798
G V Y C L+G C D G W+G P C V C +P + HG +
Sbjct: 2792 VGAVVRYSCIGKRTLVGNSTRMCGLD----GHWTGSLPHC-SGTSVGVCGDPGIPAHGIR 2846
Query: 799 LNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTP 858
L ++ ++ C G ++ GS C + +W P C I C P
Sbjct: 2847 LG---DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC---GVISCGNPGTPS 2900
Query: 859 NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 918
N + FS SI+Y C +GY G C+ GTW+ P C +NC P
Sbjct: 2901 NARVVFSDGLVFSS--SIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDP--- 2955
Query: 919 DGI-QKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS--QCQSDHQWNPPLAVCRSRSLAP 975
GI GL ++Y VT +C GYM+E S C D WN VC++ P
Sbjct: 2956 -GIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKP 3014
Score = 93.6 bits (231), Expect = 9e-19
Identities = 76/275 (27%), Positives = 120/275 (43%), Gaps = 24/275 (8%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P + C PP I NG++ + G+ + Y+C ++L SL + + +G+W
Sbjct: 3005 PVCKALMCKPPPLIPNGKV--VGSDFMWGSSVTYACLEGYQL----SLPAVFTCEGNGSW 3058
Query: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135
P+C F + C +P VP + R + + SV+F+C + G+ +CQ++
Sbjct: 3059 TGELPQC--FPVF--CGDPGVPSRGR-REDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSD 3113
Query: 136 NMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
W T+ P+C+ C P +P N G +V + C+ GYLL G
Sbjct: 3114 GTWSGTQ-PSCIDPTLTTCADPGVPQFG----IQNNSQGYQVGSTVLFRCQKGYLLQGST 3168
Query: 194 IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPS 253
CL + WS PP C C+ + V + +G T + C EG+ L+G
Sbjct: 3169 TRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSE 3228
Query: 254 SR-CVIAGQGVAWT-KMPVCEEIFCPSPPPILNGR 286
R C G +WT K P+C E+ PS PI R
Sbjct: 3229 HRTCKADG---SWTGKPPICLEV-RPSGRPINTAR 3259
Score = 92.4 bits (228), Expect = 2e-18
Identities = 221/1051 (21%), Positives = 360/1051 (34%), Gaps = 225/1051 (21%)
Query: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69
F+ P C S P G+ + +VG ++R+ C+ + L G + C+
Sbjct: 1722 FVYQAVPRTSATQCSSVPEPRYGK--RLGSDFSVGAIVRFECNSGYALQGSPEIECLPVP 1779
Query: 70 KVDGTWDKPAPKC----------------------EYFNKYSSCPEPIVPGGYKIR---- 103
W+ AP C Y N + + +VP G I+
Sbjct: 1780 GALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVV 1839
Query: 104 --------GSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN---MWGPTRLPTCVSVFPL 152
S G T +FS ++ +N + + + + F L
Sbjct: 1840 SFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHL 1899
Query: 153 E--------CPALPMIHNGHHTSEN--VGSIAPGLSVTYSCESGYLLVGEKIINCLSSG- 201
E CP + NG T E V + V++ CE GY L G I+C+
Sbjct: 1900 EYKTVGLSSCPEPAVPSNGVKTGERYLVNDV-----VSFQCEPGYALQGHAHISCMPGTV 1954
Query: 202 -KWSAVPPTCEEARCKSLGRFPNGKVKEPP--ILRVGVTANFFCDEGYRLQGPPSSRCVI 258
+W+ PP C A+C G V+E IL G N+ P + C
Sbjct: 1955 RRWNYPPPLCI-AQC-------GGTVEEMEGVILSPGFPGNY----------PSNMDC-- 1994
Query: 259 AGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318
+W K+ + P+ G HI + ++ +P+ + +I I
Sbjct: 1995 -----SW-KIAL----------PVGFGAHI----------QFLNFSTEPNHD----YIEI 2024
Query: 319 GESTLRCTVDSQKTGTWSGPA-PRCELSTSA-----VQCPHPQILRGRMVSGQKDRYTYN 372
S+ G +SG P LSTS H Q G + Q Y++
Sbjct: 2025 RNGPYET---SRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQ 2081
Query: 373 DTVIFACMFGFTLKGSKQIRCN----AQGTWEPSAPVCE----KECQAPPNILNGQKEDR 424
I + + GF L ++ A W+ P CE +EC P NG
Sbjct: 2082 ---ISSFLRGFDLSELERTNSTPPVAASYVWDLD-PGCEAYELQECPDPEPFANG----- 2132
Query: 425 HMVR---FDPGTSIKYSCNPGYVLVGEESIQCT--SEGVWTPPVPQCKVAACEATGRQLL 479
+VR ++ G S+ + C PGY L G + C + W P+P+C+V
Sbjct: 2133 -IVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC--------- 2182
Query: 480 TKPQHQFVRPDVNSSCGEGYKLS-GSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAH 538
++ SS G Y S Y Q + W + + P+ +
Sbjct: 2183 --------GGNITSSNGTVYSPGFPSPYSSSQDCV-WLITV-----------PIGHGVRL 2222
Query: 539 TGSSLEDFPYGTTVTYTCNP---GPERGVEFSLIGESTIRCTSND-----QERGTWSGPA 590
S L+ P G +T P P GV + + T++ +SN G
Sbjct: 2223 NLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIF 2282
Query: 591 PLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN-- 648
+ + +C I ++ + + D V ++C GFTL G+ + CK
Sbjct: 2283 AIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYL 2342
Query: 649 TWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWF 708
++ P+CE V EL S +++ S Y +Q C W
Sbjct: 2343 QFEGPPPICE------VHCPTNELLTDSTGVILSQSYPGSYP----QFQTCS------WL 2386
Query: 709 KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKG 768
++ I + ++ + G + G Y + S +
Sbjct: 2387 VRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNY--SAPLIVTSSSNSV 2444
Query: 769 HGSWSGPSP------QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIM 822
+ WS + S P P + HG+ L +T + ++ CN G+ +
Sbjct: 2445 YLRWSSDHAYNRKGFKIRYSAPYCSLPRAPL-HGFILGQTST--QPGGSIHFGCNAGYRL 2501
Query: 823 NGSRVIRCHTD----NTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILY 878
G + C + W +P C + G P PK NG G ++ G +Y
Sbjct: 2502 VGHSMAICTRHPQGYHLWSEAIPLC-QALSCGLPEAPK--NGMVFG---KEYTVGTKAMY 2555
Query: 879 SCDQGYLLV--GEALLLCTHEGTWS--QPAPHCKEVNCSSPADMDGIQKG---LEPRKMY 931
SC +GY L EA C G WS P C V C + + ++ G L Y
Sbjct: 2556 SCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSI-SVEHGRWRLIFETQY 2614
Query: 932 QYGAVVTLECEDGYMLEGSPQSQCQSDHQWN 962
Q+ A + L C+ GY G +CQ++ +W+
Sbjct: 2615 QFQAQLMLICDPGYYYTGQRVIRCQANGKWS 2645
Score = 67.4 bits (163), Expect = 7e-11
Identities = 174/851 (20%), Positives = 275/851 (32%), Gaps = 179/851 (21%)
Query: 85 FNKYS--SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN--MWGP 140
F++Y C EP VP Y IR + GD++TF+C + + G + C +W
Sbjct: 1031 FSEYDLEPCEEPEVPA-YSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWS- 1088
Query: 141 TRLPTCVSVF---------PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191
+ LP CV+ L P P+ +N +H PG + + L G
Sbjct: 1089 SPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG 1148
Query: 192 EKI-------------------------INCLSSGKWSAVPPTCEEA------------- 213
+ + +N SS W E
Sbjct: 1149 DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFEL 1208
Query: 214 -RCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVC 271
+C+ G G G + +F CD GY L+G C ++G+ W + +P C
Sbjct: 1209 IKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLC-LSGERRTWDRPLPTC 1267
Query: 272 EEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTV---- 327
G ++ G +++ E +N I E+ CT+
Sbjct: 1268 VA-------------ECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHF 1314
Query: 328 ---DSQKTGT----WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACM 380
D+++ W GP L P+ L T+N V+
Sbjct: 1315 LVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHS----------TFNSVVLQFST 1364
Query: 381 FGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCN 440
FT K I+ + C P NG + ++ G S + C+
Sbjct: 1365 DFFTSKQGFAIQFSVSTA---------TSCNDPGIPQNGSRSGDS---WEAGDSTVFQCD 1412
Query: 441 PGYVLVGEESIQCT---SEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE 497
PGY L G I C + W P P C +A C LT P + P+
Sbjct: 1413 PGYALQGSAEISCVKIENRFFWQPSPPTC-IAPCGGD----LTGPSGVILSPNYPEPYPP 1467
Query: 498 GYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPV----IYNGAHTGSSLEDFPYGTTVT 553
G + V T+ I L I P IY+G + S L YG+ +
Sbjct: 1468 GKECDWKV------TVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQL- 1520
Query: 554 YTCNPGPERGVEFSLIGESTIRCTSNDQERG----TWSGPAPLCKLSLLAVQCSHVHIAN 609
PG SL R ++ G P C I N
Sbjct: 1521 ----PGRIESSSNSLF--LAFRSDASVSNAGFVIDYTENPRESC--------FDPGSIKN 1566
Query: 610 GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRC----KADNTWDPEIPVCEKETCQHV 665
G ++ + +VT+ C+ G+ ++G+S + C W+ PVC
Sbjct: 1567 GTRVG---SDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC-------- 1615
Query: 666 RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVI-----HCH 720
P G + DG L+ + Q + ++F +P V+ H
Sbjct: 1616 -----TAPCGGQY-----VGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFH 1665
Query: 721 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--PQ 778
V H G + L + + L ++ + +KG G Q
Sbjct: 1666 TALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQ 1725
Query: 779 CLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC----HTD 833
+ T+C + PE ++G +L S +S IV +CN G+ + GS I C
Sbjct: 1726 AVPRTSATQCSSVPEPRYGKRLG---SDFSVGAIVRFECNSGYALQGSPEIECLPVPGAL 1782
Query: 834 NTWVPGVPTCI 844
W PTC+
Sbjct: 1783 AQWNVSAPTCV 1793
Score = 63.9 bits (154), Expect = 7e-10
Identities = 207/1028 (20%), Positives = 349/1028 (33%), Gaps = 187/1028 (18%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SCG P GR + G +++ C F L+G+K++ C + + W P
Sbjct: 520 SCGDPGIPAYGRRE--GSRFHHGDTLKFECQPAFELVGQKAITC----QKNNQWSAKKPG 573
Query: 82 CEY--FNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
C + F ++S P G + + P +G+ + C + N++
Sbjct: 574 CVFSCFFNFTS------PSGVVLSPNYPEDYGNHLH--CVWLILARPESRIHLAFNDIDV 625
Query: 140 PTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS 199
+ V I +G V G + S S + + S
Sbjct: 626 EPQFDFLV------------IKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHS 673
Query: 200 SGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYR-LQGPPSSRC 256
+GK ++ T C G NGK + L++G + +F CDEG+ QG + C
Sbjct: 674 TGKRGFNITFTTFRHNECPDPGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSETITC 732
Query: 257 VIAGQGVAWTKMPV-CEE------------IFCPSPPPILNGRHIGNSLANVSYGSIVTY 303
V+ V W + CE I P P + G +
Sbjct: 733 VLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKI 792
Query: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGP-APRCELSTS-------AVQCPHPQ 355
T D E VN+ + R T + G + G P+ +STS + H
Sbjct: 793 TFDRFKTE-VNYDTLEVRDGR-TYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSD 850
Query: 356 I---LRGRMVSGQKDR----------------YTYNDTVIFACMFGFTLKGSKQIRCNAQ 396
I LR ++ Q D + V F+C G+TL + + C
Sbjct: 851 IGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPN 910
Query: 397 GTWEPSAPVCEKEC-------------QAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443
W + P CE C P+ ++ G + ++ + +
Sbjct: 911 FQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFH 970
Query: 444 VLVGEESIQCTSEGVWTPPVPQ---CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYK 500
+ G + + T G +T P+ Q ++ A + G Q +F+ D + S EG+
Sbjct: 971 LESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFI-SDFSMSY-EGFN 1028
Query: 501 LSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGP 560
++ S Y ++ C+E P A++ F G T+T++C PG
Sbjct: 1029 ITFSEY-----------DLEPCEEPEVP--------AYSIRKGLQFGVGDTLTFSCFPG- 1068
Query: 561 ERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPY 620
+ L G + I C R WS P P C +C + + P
Sbjct: 1069 -----YRLEGTARITCLGG--RRRLWSSPLPRC-----VAECGNSVTGTQGTLLSPNFPV 1116
Query: 621 FYNDTVTFKC-YSGFTLKGSS-QIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRV 678
YN+ +C YS T G Q++ +A + ++ + S + L S
Sbjct: 1117 NYNN--NHECIYSIQTQPGKGIQLKARAFELSEGDV----LKVYDGNNNSARLLGVFSHS 1170
Query: 679 ELVNTSCQDGYQLTGHAYQMCQDAEN-----GIWFKKIPLCKVIHCHPPPVIVNGKHTGM 733
E++ + + DAEN + F L K C P G +
Sbjct: 1171 EMMGVTLNS--TSSSLWLDFITDAENTSKGFELHFSSFELIK---CEDPGTPKFGYK--V 1223
Query: 734 MAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVT---RCPN 790
E G+ VS+ CD G+ L G ++L C S + +W P P C+ T
Sbjct: 1224 HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGER--RTWDRPLPTCVAECGGTVRGEVSG 1281
Query: 791 PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT------WVPGVPTCI 844
+ GY H+ N I ++ G + G + T+ W V + +
Sbjct: 1282 QVLSPGYPAPYEHNL---NCIWTIEAEAGCTI-GLHFLVFDTEEVHDVLRIWDGPVESGV 1337
Query: 845 KKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPA 904
+ P PK + + +FS + ++ QG+ A+ T
Sbjct: 1338 LLKELSGPALPKDLHSTF-NSVVLQFS---TDFFTSKQGF-----AIQFSVSTAT----- 1383
Query: 905 PHCKEVNCSSPADMDGI-QKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC---QSDHQ 960
+C+ P GI Q G ++ G +C+ GY L+GS + C ++
Sbjct: 1384 ------SCNDP----GIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFF 1433
Query: 961 WNPPLAVC 968
W P C
Sbjct: 1434 WQPSPPTC 1441
Score = 54.7 bits (130), Expect = 4e-07
Identities = 109/476 (22%), Positives = 164/476 (34%), Gaps = 98/476 (20%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
SC P I NG + + + +G+ + Y C G + + G +L CI W+ P P
Sbjct: 1557 SCFDPGSIKNG--TRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPV 1614
Query: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPT 141
C P G + GS D V + N+ N C ++ T
Sbjct: 1615 C------------TAPCGGQYVGS------DGVVLS--PNYPQNYTSGQIC----LYFVT 1650
Query: 142 RLPTCV-----SVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIIN 196
V + F + +H+GH + S LS +++ ES L +++
Sbjct: 1651 VPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLS---SLSGSHTGESLPLATSNQVLI 1707
Query: 197 CLSSG----------KWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGY 246
S+ + AVP T +C S+ GK + VG F C+ GY
Sbjct: 1708 KFSAKGLAPARGFHFVYQAVPRT-SATQCSSVPEPRYGK-RLGSDFSVGAIVRFECNSGY 1765
Query: 247 RLQGPPSSRCV-IAGQGVAW-TKMPVC------------EEIFCPS-PPPILNGRH---- 287
LQG P C+ + G W P C I P P P LN +
Sbjct: 1766 ALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWK 1825
Query: 288 ------IGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341
G + VS+ + + + N + + S TV + T +
Sbjct: 1826 IVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLH 1885
Query: 342 --CELSTSAV------------QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKG 387
++S SA CP P + + +G +RY ND V F C G+ L+G
Sbjct: 1886 FYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTG--ERYLVNDVVSFQCEPGYALQG 1943
Query: 388 SKQIRCNAQGT---WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCN 440
I C GT W P+C +C G E+ V PG Y N
Sbjct: 1944 HAHISC-MPGTVRRWNYPPPLCIAQC-------GGTVEEMEGVILSPGFPGNYPSN 1991
Score = 49.3 bits (116), Expect = 2e-05
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 70 KVDGTWDKPAPKCEYFN-KYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK 128
+ DG+ K Y + SC +P +P Y R + + HGD++ F C+ F + G K
Sbjct: 499 QTDGSGSSLGFKASYEEIEQGSCGDPGIPA-YGRREGSRFHHGDTLKFECQPAFELVGQK 557
Query: 129 SVWCQANNMWGPTRLPTCV 147
++ CQ NN W + P CV
Sbjct: 558 AITCQKNNQWS-AKKPGCV 575
Score = 47.4 bits (111), Expect = 7e-05
Identities = 61/274 (22%), Positives = 96/274 (35%), Gaps = 63/274 (22%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C P I NG G + G+ V+Y C G+ + G L C G W+ P P
Sbjct: 1558 CFDPGSIKNGTRVG---SDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPV 1614
Query: 779 C--------LRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG------ 824
C + S V PN Y N T + +V +++ G
Sbjct: 1615 CTAPCGGQYVGSDGVVLSPN------YPQNYTSGQIC---LYFVTVPKDYVVFGQFAFFH 1665
Query: 825 ---SRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD 881
+ V+ H ++ + + + +G+HTG ++ + ++
Sbjct: 1666 TALNDVVEVHDGHSQHSRLLSSL--------------SGSHTGESLPLATSNQVLIKFSA 1711
Query: 882 QGYLLVGEALLLCTHEGTWS--QPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVVT 938
+G L G Q P CSS P G + G + + GA+V
Sbjct: 1712 KG---------LAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSD----FSVGAIVR 1758
Query: 939 LECEDGYMLEGSPQSQC----QSDHQWNPPLAVC 968
EC GY L+GSP+ +C + QWN C
Sbjct: 1759 FECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Score = 45.8 bits (107), Expect = 2e-04
Identities = 108/506 (21%), Positives = 169/506 (33%), Gaps = 139/506 (27%)
Query: 165 HTSENVGSIAPGLS----------VTYSCESGYLLVGEKIINCLS----SGKWSAVPPTC 210
HT N G + G+ V YSC G+ L G ++ C + S W P+C
Sbjct: 137 HTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Query: 211 E-EARCKSLGRFPNGKVKEPP---------------ILRVGVTA-----NFFCDEGY--- 246
+ C R +G + P + +G T +F ++GY
Sbjct: 197 RADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFL 256
Query: 247 RLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGR-----HIGNSLANVSYGSIV 301
+ G S G + P P+++ + H + + G
Sbjct: 257 EVTGTEGSSLWFTGASL---------------PAPVISSKNWLRLHFTSDGNHRQRGFSA 301
Query: 302 TYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL-RGR 360
Y ++ + G + +SQKT + + +S CP P I RG+
Sbjct: 302 QYQV----KKQIELKSRGVKLMPSKDNSQKTSVLT----QVGVSQGHNMCPDPGIPERGK 353
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC----NAQGTWEPSAPVCE-KECQA--- 412
+ + +V F C G+ L+GSK+I C + W PVC + C A
Sbjct: 354 RLGSD---FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLR 410
Query: 413 -------PPNILNGQKEDRHMV----RFDPGTSIK-----YSCNPGYVLV-----GEESI 451
PN + H V +P IK + GY + G++
Sbjct: 411 GPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGD 470
Query: 452 QCTSEGVWT-PPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
Q T + T VP V+ T Q + S G+K S Y+E +
Sbjct: 471 QKTVLYILTGTSVPDLIVS----------TNHQMWLLFQTDGSGSSLGFKAS---YEEIE 517
Query: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
+ +C P + G GS F +G T+ + C P F L+G
Sbjct: 518 -------------QGSCGDPGIPAYGRREGSR---FHHGDTLKFECQPA------FELVG 555
Query: 571 ESTIRCTSNDQERGTWSGPAPLCKLS 596
+ I C N+Q WS P C S
Sbjct: 556 QKAITCQKNNQ----WSAKKPGCVFS 577
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/245 (23%), Positives = 91/245 (37%), Gaps = 45/245 (18%)
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSE----GVWTPPVPQCKVAACEATGR---QLLTK 481
F G+S++++CN GY L G + I C W+ P C+ C+A R ++T
Sbjct: 359 FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITS 418
Query: 482 PQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGS 541
P ++ D N+ C W IT P + A
Sbjct: 419 PNFP-IQYDNNAHC------------------VWI--------ITALNPSKVIKLAFEEF 451
Query: 542 SLEDFPYGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQE----RGTWSGPAPLCKL 595
LE TV G ++ V + L G S + ++N Q + SG + K
Sbjct: 452 DLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKA 511
Query: 596 SLLAVQ---CSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDP 652
S ++ C I + G + + DT+ F+C F L G I C+ +N W
Sbjct: 512 SYEEIEQGSCGDPGIPAYGRREGSR--FHHGDTLKFECQPAFELVGQKAITCQKNNQWSA 569
Query: 653 EIPVC 657
+ P C
Sbjct: 570 KKPGC 574
Score = 44.7 bits (104), Expect = 5e-04
Identities = 66/282 (23%), Positives = 100/282 (35%), Gaps = 46/282 (16%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C P + NG G F G++V Y C+ GF+L G L C + S+ +W P P
Sbjct: 139 CGNPGRLPNGIQQG---STFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTH--SAYSHN---------------DIVYVDCNPGFI 821
C C ++ H S Y +N +V++D
Sbjct: 196 CRAD---DACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG 252
Query: 822 MNGSRVIRCHTDNTWVPG----VPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSIL 877
+ V + W G P K ++ T +GNH G S
Sbjct: 253 YDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRL---HFTSDGNHR-------QRGFSAQ 302
Query: 878 YSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM---DGI-QKGLEPRKMYQY 933
Y + L + L + SQ +V S +M GI ++G ++
Sbjct: 303 YQVKKQIELKSRGVKLMPSKDN-SQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRL 361
Query: 934 GAVVTLECEDGYMLEGSPQSQCQ--SD--HQWNPPLAVCRSR 971
G+ V C +GY L+GS + C SD W+ VCR+R
Sbjct: 362 GSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAR 403
Score = 43.9 bits (102), Expect = 8e-04
Identities = 54/222 (24%), Positives = 81/222 (36%), Gaps = 47/222 (21%)
Query: 233 RVGVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCEEIFCPS----PPPILNGR 286
R+G + F C+EGY LQG C+ ++ AW+ PVC C + P I+
Sbjct: 360 RLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSP 419
Query: 287 HIGNSLANVSYGSIVTYTCDP-----------DPEEGVNFILIGESTL---RCTVDSQKT 332
+ N ++ + +P D E G + + +G+ + TV T
Sbjct: 420 NFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILT 479
Query: 333 GT-------------W-------SGPAPRCELSTSAVQ---CPHPQI-LRGRMVSGQKDR 368
GT W SG + + S ++ C P I GR + R
Sbjct: 480 GTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRR---EGSR 536
Query: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC 410
+ + DT+ F C F L G K I C W P C C
Sbjct: 537 FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578
Score = 43.5 bits (101), Expect = 0.001
Identities = 79/353 (22%), Positives = 120/353 (33%), Gaps = 67/353 (18%)
Query: 352 PHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQ 411
P P+ LR R+ Q I + +L+ +AQG + C
Sbjct: 87 PQPENLRTRLTGFQLP------ATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCG 140
Query: 412 APPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQCK 467
P + NG ++ F+ G ++YSCN G+ L G + C + W P+P C+
Sbjct: 141 NPGRLPNGIQQGS---TFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197
Query: 468 V-AACEAT--GRQLLTKPQHQFVRPDVNSSC--------GEGYKL--------SGSVYQE 508
AC T G+ + H N+ C G+ L G + E
Sbjct: 198 ADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLE 257
Query: 509 CQGT---IPWFMEIRLCKEITCPPPPVI----YNGAHTGSSLEDFPYGTTVTYTCNPGPE 561
GT WF L P PVI + H S G + Y +
Sbjct: 258 VTGTEGSSLWFTGASL-------PAPVISSKNWLRLHFTSDGNHRQRGFSAQYQV----K 306
Query: 562 RGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN-GYKISGKE--A 618
+ +E G + N Q+ L+ + V H + G GK +
Sbjct: 307 KQIELKSRGVKLMPSKDNSQKTSV---------LTQVGVSQGHNMCPDPGIPERGKRLGS 357
Query: 619 PYFYNDTVTFKCYSGFTLKGSSQIRCKADN----TWDPEIPVCEKETCQ-HVR 666
+ +V F C G+ L+GS +I C + W PVC C H+R
Sbjct: 358 DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLR 410
Score = 42.0 bits (97), Expect = 0.003
Identities = 99/509 (19%), Positives = 158/509 (31%), Gaps = 138/509 (27%)
Query: 526 TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGT 585
TC P + NG GS+ F G V Y+CN G F L G + + C + + T
Sbjct: 138 TCGNPGRLPNGIQQGST---FNLGDKVRYSCNLG------FFLEGHAVLTCHAGSENSAT 188
Query: 586 WSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCK 645
W P P C+ C IS P Y++
Sbjct: 189 WDFPLPSCRAD---DACGGTLRGQSGIISSPHFPSEYHN--------------------N 225
Query: 646 ADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENG 705
AD TW L EL + ++ +DGY ++ +
Sbjct: 226 ADCTW----------------TILAELGDTIALVFIDFQLEDGYDF----LEVTGTEGSS 265
Query: 706 IWFKKIPLCKVIHCHPPPVIVNGK----HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ 761
+WF L P PVI + H + G Y+ +K+++
Sbjct: 266 LWFTGASL-------PAPVISSKNWLRLHFTSDGNHRQRGFSAQYQV--------KKQIE 310
Query: 762 CRS------DSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVD 815
+S SK + + Q S CP+P + K + S + V
Sbjct: 311 LKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGK--RLGSDFRLGSSVQFT 368
Query: 816 CNPGFIMNGSRVIRCHTDN----TWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGN----- 866
CN G+ + GS+ I C + W P C + C + P+G T N
Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARM---CDAHLRGPSGIITSPNFPIQY 425
Query: 867 ---------IARFSPGMSIL-----YSCDQGY--LLVGEA-------------------- 890
I +P I + ++GY L VG+
Sbjct: 426 DNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPD 485
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQK-----------GLEPRKMYQYGAVVTL 939
L++ T+ W + A + I++ G + +G +
Sbjct: 486 LIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKF 545
Query: 940 ECEDGYMLEGSPQSQCQSDHQWNPPLAVC 968
EC+ + L G CQ ++QW+ C
Sbjct: 546 ECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/61 (39%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
+CG+P + NG I ST +G +RYSC+ F L G L C + TWD P P
Sbjct: 138 TCGNPGRLPNG-IQQGST-FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 82 C 82
C
Sbjct: 196 C 196
Score = 39.3 bits (90), Expect = 0.019
Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 34/265 (12%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFY-LLGEKKLQCRSDSKGHGSWSGPSP 777
C P V VNGK G ++ G+ +S+ CD+GF G + + C +G W+
Sbjct: 691 CPDPGVPVNGKRFG---DSLQLGSSISFLCDEGFLGTQGSETITCVL-KEGSVVWNSAVL 746
Query: 778 QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIV---YVDCNPGFIMNGSRVIRCHTDN 834
+C +P +P G L+ + + + ++ PG+ + I
Sbjct: 747 RC-EAPCGGHLTSPS---GTILSPGWPGFYKDALSCAWVIEAQPGYPIK----ITFDRFK 798
Query: 835 TWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC 894
T V ++ P +G + S + +L+S D+ + +G L
Sbjct: 799 TEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQL--- 855
Query: 895 THEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954
T + + HC + ++G + G + + GA+VT C+ GY L +
Sbjct: 856 -RYETITLQSDHCLDPGIP----VNGQRHGND----FYVGALVTFSCDSGYTLSDGEPLE 906
Query: 955 CQSDHQWNPPLAVCRSRSLAPVLCG 979
C+ + QW+ L C + LCG
Sbjct: 907 CEPNFQWSRALPSCEA------LCG 925
Score = 39.3 bits (90), Expect = 0.019
Identities = 21/66 (31%), Positives = 27/66 (40%), Gaps = 2/66 (3%)
Query: 905 PHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ--SDHQWN 962
P C+ D + G+ Y G VT EC GY L G P CQ ++ W+
Sbjct: 2113 PGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWD 2172
Query: 963 PPLAVC 968
PL C
Sbjct: 2173 HPLPKC 2178
Score = 35.8 bits (81), Expect = 0.21
Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Query: 88 YSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC 132
++ CP+P +P K GS +R G SV F C + + G+K + C
Sbjct: 340 HNMCPDPGIPERGKRLGSD-FRLGSSVQFTCNEGYDLQGSKRITC 383
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Query: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ--SDHQWNPPL 965
K V SS + G++ + Y VV+ +CE GY L+G C + +WN P
Sbjct: 1902 KTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPP 1961
Query: 966 AVC 968
+C
Sbjct: 1962 PLC 1964
Score = 32.7 bits (73), Expect = 1.8
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 8/65 (12%)
Query: 784 PVTRCPNP-EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDN----TWVP 838
P C NP + +G + T ++ D V CN GF + G V+ CH + TW
Sbjct: 135 PSHTCGNPGRLPNGIQQGST---FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDF 191
Query: 839 GVPTC 843
+P+C
Sbjct: 192 PLPSC 196
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 251 bits (641), Expect = 2e-66
Identities = 169/517 (32%), Positives = 240/517 (46%), Gaps = 63/517 (12%)
Query: 176 GLSVTYSCESGYLLV-GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRV 234
G ++ Y+C GY+ + + C S G+W C RC+ G NG+V+ L
Sbjct: 74 GTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132
Query: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLA 293
G F C EG+ L G +SRC + +GV W+ +P CE + C PP I NGRH G
Sbjct: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENF 192
Query: 294 NVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH 353
+YG VTY+CDP F L+G +++ CTV+++ G W P CE T C
Sbjct: 193 -YAYGFSVTYSCDP------RFSLLGHASISCTVENETIGVWRPSPPTCEKIT----CRK 241
Query: 354 PQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQA 412
P + G MVSG Y Y DT++F C GF L+GS I C+A W PS P CE C
Sbjct: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCIN 301
Query: 413 PPNILNGQ--------KEDRHMVRFDPGTSIKYSCNPGYVLVGEE--SIQCTSEGVWTPP 462
P+I + KED ++V GT ++Y C+PGY +E ++ C WT P
Sbjct: 302 LPDIPHASWETYPRPTKEDVYVV----GTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-P 356
Query: 463 VPQCKVAACEATGRQLLTKPQHQFVRP----------DVNSSCGEGYKLSGSVYQECQGT 512
C+ C QH+ RP +++ SC E + S CQG
Sbjct: 357 YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGD 412
Query: 513 IPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572
W C +I C PP I +G + SS F + + Y C+ G + L+G++
Sbjct: 413 GTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF-FKEEIIYECDKG------YILVGQA 464
Query: 573 TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYS 632
+ C+ + WS PAP CK C + NG ++S + Y + VT +C S
Sbjct: 465 KLSCSYSH-----WSAPAPQCK-----ALCRKPELVNG-RLSVDKDQYVEPENVTIQCDS 513
Query: 633 GFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSL 669
G+ + G I C + TW PE+P CE ET + Q L
Sbjct: 514 GYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVL 550
Score = 202 bits (515), Expect = 1e-51
Identities = 150/531 (28%), Positives = 228/531 (42%), Gaps = 61/531 (11%)
Query: 404 PVCEKECQAPPNILNGQKEDRHMV--RFDPGTSIKYSCNPGYVLV-GEESIQCTSEGVWT 460
P C PP + D + RF GT++KY+C PGYV +++ C S+G W
Sbjct: 44 PAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV 103
Query: 461 PPVPQCKVAACEATGR----QLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGT---I 513
C C G Q+ K F + SC EG+ L GS C+ +
Sbjct: 104 YNT-FCIYKRCRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGV 161
Query: 514 PWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST 573
W + C+ + C PPP I NG H+G + YG +VTY+C+P FSL+G ++
Sbjct: 162 GWSHPLPQCEIVKCKPPPDIRNGRHSGEE-NFYAYGFSVTYSCDP------RFSLLGHAS 214
Query: 574 IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSG 633
I CT ++ G W P C+ + C +++G +SG Y Y DT+ FKC G
Sbjct: 215 ISCTVENETIGVWRPSPPTCE----KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKG 270
Query: 634 FTLKGSSQIRCKADNTWDPEIPVCEKETC------QHVRQSLQELPAGSRVELVNT---- 683
F L+GSS I C AD+ W+P P CE +C H P V +V T
Sbjct: 271 FVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRY 330
Query: 684 SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN------ 737
C GY+ T +N W C+ + C P P + NG+ T
Sbjct: 331 RCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEAL-CCPEPKLNNGEITQHRKSRPANHCV 388
Query: 738 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGY 797
+ YG+E+S+ C + + + +G G+WS +P C + P P++ HG+
Sbjct: 389 YFYGDEISFSC--------HETSRFSAICQGDGTWSPRTPSC---GDICNFP-PKIAHGH 436
Query: 798 KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKT 857
+ ++ +I+Y +C+ G+I+ G + C + W P C KA P+
Sbjct: 437 YKQSSSYSFFKEEIIY-ECDKGYILVGQAKLSCSYSH-WSAPAPQC--KALC---RKPEL 489
Query: 858 PNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908
NG + P ++ CD GY +VG + C+ TW P C+
Sbjct: 490 VNGRLSVDKDQYVEP-ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
Score = 172 bits (437), Expect = 1e-42
Identities = 159/546 (29%), Positives = 224/546 (41%), Gaps = 78/546 (14%)
Query: 11 LALVAPGVLGISCGSPPPILNGR---ISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCI 66
+A + P VLG +CG PP + I+ T GT ++Y+C G R ++L C
Sbjct: 39 IAALLPAVLG-NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCN 97
Query: 67 TKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNG 126
+ DG W F Y C P ++ T G + F+C F + G
Sbjct: 98 S----DGEW-----VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIG 148
Query: 127 NKSVWCQANNM---WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSC 183
+ + C+ + W LP C V +C P I NG H+ E A G SVTYSC
Sbjct: 149 STTSRCEVQDRGVGWSHP-LPQCEIV---KCKPPPDIRNGRHSGEE-NFYAYGFSVTYSC 203
Query: 184 ESGYLLVGEKIINCL----SSGKWSAVPPTCEEARCK----SLGRFPNGKVKEPPILRVG 235
+ + L+G I+C + G W PPTCE+ C+ S G +G PI
Sbjct: 204 DPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSG---FGPIYNYK 260
Query: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG------RHI 288
T F C +G+ L+G C + W P CE C + P I + R
Sbjct: 261 DTIVFKCQKGFVLRGSSVIHCDADSK---WNPSPPACEPNSCINLPDIPHASWETYPRPT 317
Query: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
+ V G+++ Y C P + + E T TV QK W+ P CE A
Sbjct: 318 KEDVYVV--GTVLRYRCHPGYKPTTD-----EPT---TVICQKNLRWT-PYQGCE----A 362
Query: 349 VQCPHPQILRGRMVSGQKDR------YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPS 402
+ CP P++ G + +K R Y Y D + F+C C GTW P
Sbjct: 363 LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPR 418
Query: 403 APVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP 462
P C C PP I +G + F I Y C+ GY+LVG+ + C S W+ P
Sbjct: 419 TPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYILVGQAKLSC-SYSHWSAP 476
Query: 463 VPQCKVAACE----ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLSGSVYQECQGTIPWFM 517
PQCK A C GR L+ + Q+V P+ V C GY + G C G W+
Sbjct: 477 APQCK-ALCRKPELVNGR--LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYP 533
Query: 518 EIRLCK 523
E+ C+
Sbjct: 534 EVPKCE 539
Score = 168 bits (425), Expect = 3e-41
Identities = 137/506 (27%), Positives = 214/506 (42%), Gaps = 59/506 (11%)
Query: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
C P + NG++ T ++ G+ I +SCS F LIG + C +D+ G W P P+C
Sbjct: 113 CRHPGELRNGQVEI-KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG-WSHPLPQC 170
Query: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN----MW 138
E P P + G Y +G SVT++C FS+ G+ S+ C N +W
Sbjct: 171 EI---VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227
Query: 139 GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGL----SVTYSCESGYLLVGEKI 194
P+ PTC + C + H E V P ++ + C+ G++L G +
Sbjct: 228 RPSP-PTCEKI---TCRKPDVSH-----GEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278
Query: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPP------ILRVGVTANFFCDEGYRL 248
I+C + KW+ PP CE C +L P+ + P + VG + C GY+
Sbjct: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYK- 337
Query: 249 QGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNG---RHIGNSLAN---VSYGSIVT 302
VI + + WT CE + CP P + NG +H + AN YG ++
Sbjct: 338 PTTDEPTTVICQKNLRWTPYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEIS 396
Query: 303 YTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV 362
++C T R + Q GTWS P C P P+I G
Sbjct: 397 FSC--------------HETSRFSAICQGDGTWSPRTPSC---GDICNFP-PKIAHGHYK 438
Query: 363 SGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKE 422
+ + + +I+ C G+ L G ++ C + W AP C+ C+ P ++NG+
Sbjct: 439 QSSSYSF-FKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKALCR-KPELVNGRLS 495
Query: 423 DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP 482
+P ++ C+ GY +VG +SI C+ W P VP+C+ E + L K
Sbjct: 496 VDKDQYVEP-ENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKR 554
Query: 483 QHQFV-RPDVNSSCGEGYKLSGSVYQ 507
Q + P+ E YKLS + Q
Sbjct: 555 LMQCLPNPEDVKMALEVYKLSLEIEQ 580
Score = 162 bits (410), Expect = 2e-39
Identities = 134/507 (26%), Positives = 217/507 (42%), Gaps = 53/507 (10%)
Query: 368 RYTYNDTVIFACMFGFTLKGSKQ-IRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHM 426
R+ T+ + C+ G+ S Q + CN+ G W + K C+ P + NGQ E +
Sbjct: 70 RFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTD 129
Query: 427 VRFDPGTSIKYSCNPGYVLVGEESIQCTSE--GV-WTPPVPQCKVAACEA-----TGRQL 478
+ F G+ I++SC+ G+ L+G + +C + GV W+ P+PQC++ C+ GR
Sbjct: 130 LSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS 187
Query: 479 LTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIP-WFMEIRLCKEITCPPPPVIY 534
+ + + V SC + L G C TI W C++ITC P V +
Sbjct: 188 GEENFYAYGF-SVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSH 246
Query: 535 NGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCK 594
+G + Y T+ + C G F L G S I C ++ + W+ P C+
Sbjct: 247 GEMVSGFG-PIYNYKDTIVFKCQKG------FVLRGSSVIHCDADSK----WNPSPPACE 295
Query: 595 LSLLAVQCSHVHIA-NGYKISGKEAPYFYNDTVTFKCYSGF--TLKGSSQIRCKADNTWD 651
+ H + Y KE Y + ++C+ G+ T + + C+ + W
Sbjct: 296 PNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT 355
Query: 652 PEIPVCEKETCQH-------VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAEN 704
P CE C + Q + PA V T +CQ +
Sbjct: 356 P-YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQG--D 412
Query: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 764
G W + P C I C+ PP I +G + + +F + E+ YECD+G+ L+G+ KL C
Sbjct: 413 GTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSF-FKEEIIYECDKGYILVGQAKLSC-- 468
Query: 765 DSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824
+ WS P+PQC C PE+ +G +L+ Y + V + C+ G+ + G
Sbjct: 469 ---SYSHWSAPAPQCK-----ALCRKPELVNG-RLSVDKDQYVEPENVTIQCDSGYGVVG 519
Query: 825 SRVIRCHTDNTWVPGVPTCIKKAFIGC 851
+ I C + TW P VP C + GC
Sbjct: 520 PQSITCSGNRTWYPEVPKCEWETPEGC 546
Score = 151 bits (381), Expect = 3e-36
Identities = 115/413 (27%), Positives = 180/413 (43%), Gaps = 43/413 (10%)
Query: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
+ C PP I NGR S A G + YSC F L+G S+ C +++ G W P
Sbjct: 173 VKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPP 232
Query: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
CE +C +P V G + G P Y + D++ F C+ F + G+ + C A++ W
Sbjct: 233 TCEKI----TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWN 288
Query: 140 PTRLPTCVSVFPLECPALPMIHNG------HHTSENVGSIAPGLSVTYSCESGYLLVGEK 193
P+ P C P C LP I + T E+V + G + Y C GY ++
Sbjct: 289 PSP-PACE---PNSCINLPDIPHASWETYPRPTKEDVYVV--GTVLRYRCHPGYKPTTDE 342
Query: 194 --IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
+ C + +W+ P EA C + NG++ + R +F +
Sbjct: 343 PTTVICQKNLRWT--PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
Query: 252 PSSR--CVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
+SR + G G + P C +I C PP I +G H S + + + Y CD
Sbjct: 401 ETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHG-HYKQSSSYSFFKEEIIYECDK-- 456
Query: 310 EEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRY 369
+IL+G++ L C+ WS PAP+C+ C P+++ GR+ S KD+Y
Sbjct: 457 ----GYILVGQAKLSCSYSH-----WSAPAPQCK-----ALCRKPELVNGRL-SVDKDQY 501
Query: 370 TYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC-QAPPNILNGQK 421
+ V C G+ + G + I C+ TW P P CE E + +L G++
Sbjct: 502 VEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKR 554
Score = 150 bits (380), Expect = 5e-36
Identities = 133/497 (26%), Positives = 210/497 (42%), Gaps = 60/497 (12%)
Query: 494 SCGEGYKLSGSVYQ-ECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTV 552
+C GY S S C W C C P + NG + D +G+ +
Sbjct: 80 TCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKT--DLSFGSQI 136
Query: 553 TYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYK 612
++C+ G F LIG +T RC D+ G WS P P C++ V+C +
Sbjct: 137 EFSCSEG------FFLIGSTTSRCEVQDRGVG-WSHPLPQCEI----VKCKPPPDIRNGR 185
Query: 613 ISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADN----TWDPEIPVCEKETCQHVRQS 668
SG+E Y Y +VT+ C F+L G + I C +N W P P CEK TC+ S
Sbjct: 186 HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVS 245
Query: 669 LQELPAG-----SRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPP 723
E+ +G + + + CQ G+ L G + C DA++ W P C+ C P
Sbjct: 246 HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC-DADSK-WNPSPPACEPNSCINLP 303
Query: 724 VIVNGKHTGM----MAENFLYGNEVSYECDQGFYLLGEKKLQ--CRSDSKGHGSWSGPSP 777
I + + ++ G + Y C G+ ++ C+ + + W+ P
Sbjct: 304 DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLR----WT-PYQ 358
Query: 778 QCLRSPPVTRCPNPEVKHG----YKLNK--THSAYSHNDIVYVDCNPGFIMNGSRVIRCH 831
C CP P++ +G ++ ++ H Y + D + C+ + C
Sbjct: 359 GC----EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQ 410
Query: 832 TDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEAL 891
D TW P P+C C PPK +G++ + F I+Y CD+GY+LVG+A
Sbjct: 411 GDGTWSPRTPSCGDI----CNFPPKIAHGHYKQSSSYSFFKE-EIIYECDKGYILVGQAK 465
Query: 892 LLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSP 951
L C++ WS PAP CK + C P ++G + + Y VT++C+ GY + G
Sbjct: 466 LSCSYSH-WSAPAPQCKAL-CRKPELVNG--RLSVDKDQYVEPENVTIQCDSGYGVVGPQ 521
Query: 952 QSQCQSDHQWNPPLAVC 968
C + W P + C
Sbjct: 522 SITCSGNRTWYPEVPKC 538
Score = 107 bits (266), Expect = 8e-23
Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 29/267 (10%)
Query: 718 HCHPPPVI--VNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEKKLQCRSDSKGHGSWSG 774
+C PPP + + F G + Y C G+ + L C SD G W
Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSD----GEWVY 104
Query: 775 PSPQCLRSPPVTRCPNP-EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTD 833
+ C+ RC +P E+++G KT ++ + C+ GF + GS RC
Sbjct: 105 -NTFCIYK----RCRHPGELRNGQVEIKTDLSFGSQ--IEFSCSEGFFLIGSTTSRCEVQ 157
Query: 834 NT---WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890
+ W +P C + C PPP NG H+G ++ G S+ YSCD + L+G A
Sbjct: 158 DRGVGWSHPLPQC---EIVKCKPPPDIRNGRHSGEENF-YAYGFSVTYSCDPRFSLLGHA 213
Query: 891 LLLCTHE----GTWSQPAPHCKEVNCSSPADMDG-IQKGLEPRKMYQYGAVVTLECEDGY 945
+ CT E G W P C+++ C P G + G P +Y Y + +C+ G+
Sbjct: 214 SISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP--IYNYKDTIVFKCQKGF 271
Query: 946 MLEGSPQSQCQSDHQWNPPLAVCRSRS 972
+L GS C +D +WNP C S
Sbjct: 272 VLRGSSVIHCDADSKWNPSPPACEPNS 298
Score = 55.1 bits (131), Expect = 3e-07
Identities = 36/135 (26%), Positives = 54/135 (40%), Gaps = 11/135 (8%)
Query: 20 GISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPA 79
G C PP I +G S+ I Y C + L+G+ L C W PA
Sbjct: 423 GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPA 477
Query: 80 PKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139
P+C+ + C +P + G Y ++VT C + + + G +S+ C N W
Sbjct: 478 PQCK-----ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532
Query: 140 PTRLPTCVSVFPLEC 154
P +P C P C
Sbjct: 533 P-EVPKCEWETPEGC 546
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 248 bits (634), Expect = 2e-65
Identities = 156/503 (31%), Positives = 227/503 (45%), Gaps = 38/503 (7%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235
G + Y C GY II CL + W++ C+ C++ NG ++
Sbjct: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFR 116
Query: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
+ C +GYRL G S+ C+I+G V W K PVC+ I C PP I NG S
Sbjct: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
Query: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354
YGS+VTY C+ F L+GE ++ CT + G WSGPAP+C + +C P
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPN---KCTPP 233
Query: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414
+ G +VS + ++ N+ V F C GF +KG ++C A WEP P C + CQ PP
Sbjct: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
Query: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474
++L+ ++ R F PG + YSC PGY L G + CT +G W+P P+C+V +C+
Sbjct: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
Query: 475 GRQL----LTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527
QL + P + + V+ C EG++L GS C W + +C+ +C
Sbjct: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSC 413
Query: 528 PPPPVIYNG-AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
PPV NG H + D G+ + Y+C G LIG S+ C + W
Sbjct: 414 ETPPVPVNGMVHV---ITDIHVGSRINYSCTTG------HRLIGHSSAECILSG-NTAHW 463
Query: 587 SGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTFKC------YSGFTLKGS 639
S P+C+ + C + I NG Y V++ C F L G
Sbjct: 464 SMKPPICQ----QIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGE 519
Query: 640 SQIRCKAD----NTWDPEIPVCE 658
S IR ++ W P CE
Sbjct: 520 STIRRTSEPHGNGVWSSPAPRCE 542
Score = 231 bits (589), Expect = 3e-60
Identities = 165/508 (32%), Positives = 225/508 (44%), Gaps = 48/508 (9%)
Query: 429 FDPGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCKVAACE-----ATGRQLLTKP 482
F GT + Y C PGY G SI C VWT +CK +C G + K
Sbjct: 55 FPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIK- 111
Query: 483 QHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHT 539
QF R + SC +GY+L GS C T+ W + +C I C PP I NG T
Sbjct: 112 DIQF-RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
Query: 540 GSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLA 599
S E F YG+ VTY CN G F L+GE +I CTS D + G WSGPAP C ++
Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC---IIP 227
Query: 600 VQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK 659
+C+ ++ NG +S + + N+ V F+C GF +KG S ++C+A N W+PE+P C +
Sbjct: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
Query: 660 ETCQ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPL 713
CQ H ++ ++ S + V SC+ GY L G Y C G W P
Sbjct: 288 -VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC--TPQGDWSPAAPR 344
Query: 714 CKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
C+V C + H + N G +V + CD+GF L G C W+
Sbjct: 345 CEVKSCDDFLGQLPNGHV-LFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWN 402
Query: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC-HT 832
P C R C P V ++ + + I Y C G + G C +
Sbjct: 403 SSVPVCERK----SCETPPVPVNGMVHVITDIHVGSRINY-SCTTGHRLIGHSSAECILS 457
Query: 833 DNT--WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD------QGY 884
NT W P C + I CP PP NG HTG + G + Y+CD +
Sbjct: 458 GNTAHWSMKPPICQQ---IFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514
Query: 885 LLVGEALLLCTHE----GTWSQPAPHCK 908
L+GE+ + T E G WS PAP C+
Sbjct: 515 NLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Score = 209 bits (533), Expect = 8e-54
Identities = 138/400 (34%), Positives = 182/400 (45%), Gaps = 80/400 (20%)
Query: 21 ISCGSPPPILNGRISYYSTP-IAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73
I CG PP I NG + S G+V+ Y C+ F L+GE S+ C +KD G
Sbjct: 156 IICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVG 215
Query: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGS-TPYRHGDSVTFACKTNFSMNGNKSVWC 132
W PAP+C NK C P V G + + + + + V F C+ F M G V C
Sbjct: 216 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKC 272
Query: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
QA N W P LP+C V C P + + T + + +PG V YSCE GY L G
Sbjct: 273 QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
Query: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
++C G WS P CE C LG+ PNG V P L++G +F CDEG++L+G
Sbjct: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
Query: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNG----------------------RHI 288
+S CV+AG W + +PVCE C +PP +NG R I
Sbjct: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLI 447
Query: 289 GNSLA------NVSYGSI----------------------------------VTYTCDPD 308
G+S A N ++ S+ V+YTCDP
Sbjct: 448 GHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPH 507
Query: 309 PEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
P+ G+ F LIGEST+R T + G WS PAPRCEL A
Sbjct: 508 PDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGA 547
Score = 195 bits (496), Expect = 2e-49
Identities = 116/364 (31%), Positives = 178/364 (48%), Gaps = 29/364 (7%)
Query: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQH-------VRQSLQELPAGSRV 678
+ ++C G++ + S I C ++ W C++++C++ + ++++ S++
Sbjct: 61 LNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQI 119
Query: 679 ELVNTSCQDGYQLTGHAYQMCQDAENG-IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN 737
+ SC GY+L G + C + N IW K P+C I C PP I NG T + E
Sbjct: 120 KY---SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
Query: 738 FLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNP 791
F YG+ V+Y C+ G F L+GE + C S G WSGP+PQC+ +C P
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIP---NKCTPP 233
Query: 792 EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 851
V++G ++ S +S N++V C PGF M G ++C N W P +P+C + C
Sbjct: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV----C 289
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
PPP + T + FSPG + YSC+ GY L G L CT +G WS AP C+ +
Sbjct: 290 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKS 349
Query: 912 CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968
C L P + Q GA V C++G+ L+GS S C + WN + VC
Sbjct: 350 CDDFLGQLPNGHVLFPLNL-QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
Query: 969 RSRS 972
+S
Sbjct: 409 ERKS 412
Score = 134 bits (336), Expect = 6e-31
Identities = 131/480 (27%), Positives = 193/480 (40%), Gaps = 63/480 (13%)
Query: 491 VNSSCGEGYKLSGSVYQE-CQGTIPWFMEIRLCKEITCPPPPVIYNG-AHTGSSLEDFPY 548
+N C GY SG + C W CK +C PP NG AH ++D +
Sbjct: 61 LNYECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHV---IKDIQF 115
Query: 549 GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608
+ + Y+C G + LIG S+ C + W P+C + + + IA
Sbjct: 116 RSQIKYSCPKG------YRLIGSSSATCIISGNTV-IWDNKTPVCDRIICGLPPT---IA 165
Query: 609 NGYKISGKEAPYFYNDTVTFKCYSG------FTLKGSSQIRCKADNT----WDPEIPVC- 657
NG S + Y VT+ C G F L G I C + + W P C
Sbjct: 166 NGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCI 225
Query: 658 --EKETCQHVRQSL---QELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
K T +V + S E+V CQ G+ + G ++ CQ W ++P
Sbjct: 226 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNK--WEPELP 283
Query: 713 LCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSW 772
C + C PPP +++ + T +NF G EV Y C+ G+ L G L C G W
Sbjct: 284 SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ----GDW 338
Query: 773 SGPSPQCLRSPPVTRCPN--PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
S +P+C V C + ++ +G+ L + V C+ GF + GS C
Sbjct: 339 SPAAPRC----EVKSCDDFLGQLPNGHVLFPLNLQLGAK--VDFVCDEGFQLKGSSASYC 392
Query: 831 ---HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HTGGNIARFSPGMSILYSCDQGYLL 886
++ W VP C +K+ C PP NG H I G I YSC G+ L
Sbjct: 393 VLAGMESLWNSSVPVCERKS---CETPPVPVNGMVHV---ITDIHVGSRINYSCTTGHRL 446
Query: 887 VGEALLLCTHEGT---WSQPAPHCKEVNC-SSPADMDGIQKGLEPRKMYQYGAVVTLECE 942
+G + C G WS P C+++ C + PA ++G G P YG V+ C+
Sbjct: 447 IGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG-TPLGDIPYGKEVSYTCD 505
Score = 117 bits (292), Expect = 7e-26
Identities = 109/438 (24%), Positives = 168/438 (38%), Gaps = 64/438 (14%)
Query: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
+FP GT + Y C PG G FS+I C N W+ CK
Sbjct: 54 EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTSAKDKCKRKSCRNPPDP 102
Query: 605 VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRC-KADNT--WDPEIPVCEKET 661
V NG K+ + + + C G+ L GSS C + NT WD + PVC++
Sbjct: 103 V---NGMAHVIKDIQ--FRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRII 157
Query: 662 C---------QHVRQSLQELPAGSRVELVNTSCQDG------YQLTGHAYQMC--QDAEN 704
C S + GS +V C G ++L G C +D +
Sbjct: 158 CGLPPTIANGDFTSISREYFHYGS---VVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
Query: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 764
GIW P C + + PP + NG F V + C GF + G ++C++
Sbjct: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
Query: 765 DSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824
+K W P C R P P+V H + + +S V+ C PG+ + G
Sbjct: 275 LNK----WEPELPSCSR----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
Query: 825 SRVIRCHTDNTWVPGVPTCIKKA---FIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD 881
S + C W P P C K+ F+G + PNG+ G + + CD
Sbjct: 327 STYLHCTPQGDWSPAAPRCEVKSCDDFLG-----QLPNGHVLFP--LNLQLGAKVDFVCD 379
Query: 882 QGYLLVGEALLLCT---HEGTWSQPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVV 937
+G+ L G + C E W+ P C+ +C + P ++G+ + G+ +
Sbjct: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD---IHVGSRI 436
Query: 938 TLECEDGYMLEGSPQSQC 955
C G+ L G ++C
Sbjct: 437 NYSCTTGHRLIGHSSAEC 454
Score = 92.0 bits (227), Expect = 3e-18
Identities = 79/326 (24%), Positives = 125/326 (38%), Gaps = 26/326 (7%)
Query: 671 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 730
E P G+ +N C+ GY +G + + +N +W CK C PP VNG
Sbjct: 54 EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTSAKDKCKRKSCRNPPDPVNGM- 106
Query: 731 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN 790
+ ++ + +++ Y C +G+ L+G C S W +P C R + P
Sbjct: 107 -AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCDRI--ICGLP- 161
Query: 791 PEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGV 840
P + +G + + + + +V CN G F + G I C + + W
Sbjct: 162 PTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPA 221
Query: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
P CI PP NG N + FS + + C G+ + G + + C W
Sbjct: 222 PQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKW 278
Query: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
P C V C P D+ ++ + + G V CE GY L GS C
Sbjct: 279 EPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD 337
Query: 961 WNPPLAVCRSRSLAPVLCGIAAGLIL 986
W+P C +S L + G +L
Sbjct: 338 WSPAAPRCEVKSCDDFLGQLPNGHVL 363
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 216 bits (551), Expect = 7e-56
Identities = 174/617 (28%), Positives = 257/617 (41%), Gaps = 84/617 (13%)
Query: 80 PKCEYFNKYSSCPEPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGNKSVWCQANN 136
P+CEY + C E +P + S P + +F C + +NG + C A+
Sbjct: 192 PECEYVRE---CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
Query: 137 MWGPTRLPTCVSVFPLECPALPMIHNGHHTS-ENVGSIAPGLSVTYSCESGYLLVGEKII 195
+W + P C++ +CP L + G+ T + + S ++SCE G+ LVG +++
Sbjct: 249 IW-TNKPPQCLAA---QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVV 304
Query: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPP 252
C +SG W+A P C+ +C+ L G V G + F C GYR++G
Sbjct: 305 QCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
Query: 253 SSRCVIAGQGVAWTKMPVCEEIFC-PSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEE 311
RC+ +G A +P CE I C P P+ SL Y + ++ C E
Sbjct: 365 MLRCIDSGHWSA--PLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC----AE 418
Query: 312 GVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC---PHPQILRGRMVSGQKDR 368
G F+L G +RC G W+ PAP C+ A+QC P P R S
Sbjct: 419 G--FMLRGADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVN-CSHPFGA 467
Query: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP--NILNGQKEDRHM 426
+ Y F C G L G+ ++C A G W P ECQA P +L+ Q
Sbjct: 468 FRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPP----ECQAIPCTPLLSPQNGTMTC 523
Query: 427 VRFDPGTSIK----YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC-----EATGRQ 477
V+ +S K + C+ GY L G E + CT G WT P C+ C G
Sbjct: 524 VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583
Query: 478 LLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP----- 531
+ + +F V + SC G+KL G EC + W CK I P P
Sbjct: 584 DCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
Query: 532 --------VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQER 583
+Y H G+ F + TT + CN G F+LIG+ST+ C +
Sbjct: 644 ALTTPGQGTMYCRHHPGT----FGFNTTCYFGCNAG------FTLIGDSTLSC----RPS 689
Query: 584 GTWSGPAPLCKLSLLAVQCSHVHIAN--GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQ 641
G W+ P C+ AV+CS +H+ S + Y +F C G L GS+Q
Sbjct: 690 GQWTAVTPACR----AVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQ 745
Query: 642 IRCKADNTWDPEIPVCE 658
C+ + W +P C+
Sbjct: 746 TACQENGHWSTTVPTCQ 762
Score = 204 bits (519), Expect = 3e-52
Identities = 159/603 (26%), Positives = 231/603 (38%), Gaps = 66/603 (10%)
Query: 340 PRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTW 399
P CE + PQ + S +++N F C G+ + G ++ C A G W
Sbjct: 192 PECEYVRECGELELPQHVLMNC-SHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW 250
Query: 400 EPSAPVCEKECQAPPNIL--NGQKEDRHMVR-FDPGTSIKYSCNPGYVLVGEESIQCTSE 456
P C Q PP + G H + F +S +SC G+ LVG E +QCT+
Sbjct: 251 TNKPPQC-LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
Query: 457 GVWTPPVPQCKVAACE-----ATGRQLLTKPQHQFV-RPDVNSSCGEGYKLSGSVYQECQ 510
GVWT P P CK C+ + G P F C GY++ G C
Sbjct: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
Query: 511 GTIPWFMEIRLCKEITCPP-PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569
+ W + C+ I+C P ++ SL F Y T ++ C G F L
Sbjct: 370 DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEG------FMLR 423
Query: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI--SGKEAPYFYNDTVT 627
G +RC G W+ PAP+C+ A+QC + + N ++ S + Y +
Sbjct: 424 GADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVNCSHPFGAFRYQSVCS 475
Query: 628 FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC-------QHVRQSLQELPAGSRVEL 680
F C G L G+S ++C A W+ P C+ C +Q L + S
Sbjct: 476 FTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
Query: 681 VNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN--- 737
C +GY L+G C +G W P+C+ I C P + + + +
Sbjct: 536 CQFICDEGYSLSGPERLDC--TRSGRWTDSPPMCEAIKC---PELFAPEQGSLDCSDTRG 590
Query: 738 -FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC-----LRSPPVTRCPNP 791
F G+ + CD GF L G ++C + G WS P C L +P V +CP
Sbjct: 591 EFNVGSTCHFSCDNGFKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGV-QCPAL 645
Query: 792 EVKHGYKLNKTH--SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFI 849
+ H + N Y CN GF + G + C W P C +
Sbjct: 646 TTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAV 702
Query: 850 GCPP----PPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAP 905
C P N ++ GN FS G + C +G LL G A C G WS P
Sbjct: 703 KCSELHVNKPIAMNCSNLWGN---FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVP 759
Query: 906 HCK 908
C+
Sbjct: 760 TCQ 762
Score = 191 bits (485), Expect = 3e-48
Identities = 152/613 (24%), Positives = 238/613 (38%), Gaps = 81/613 (13%)
Query: 404 PVCE--KEC---QAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
P CE +EC + P ++L + F + + C GY + G ++C + G+
Sbjct: 192 PECEYVRECGELELPQHVLMNCSHP--LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
Query: 459 WTPPVPQCKVAAC---------EATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC 509
WT PQC A C T QHQ + SC EG+ L G +C
Sbjct: 250 WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ---SSCSFSCEEGFALVGPEVVQC 306
Query: 510 QGTIPWFMEIRLCKEITCPPPPVIYNGA-HTGSSLEDFPYGTTVTYTCNPGPERGVEFSL 568
+ W +CK + C G L F YG++ + C PG + +
Sbjct: 307 TASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG------YRV 360
Query: 569 IGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH--IANGYKISGKEAPYFYNDTV 626
G +RC + G WS P P C+ A+ C + + S + Y+
Sbjct: 361 RGLDMLRCIDS----GHWSAPLPTCE----AISCEPLESPVHGSMDCSPSLRAFQYDTNC 412
Query: 627 TFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE------- 679
+F+C GF L+G+ +RC W PVC+ CQ + +P +RV
Sbjct: 413 SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDL-----PVPNEARVNCSHPFGA 467
Query: 680 -----LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMM 734
+ + +C +G L G + C G W P C+ I C P NG T +
Sbjct: 468 FRYQSVCSFTCNEGLLLVGASVLQC--LATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQ 525
Query: 735 A-ENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN--- 790
+ Y + + CD+G+ L G ++L C G W+ P C +CP
Sbjct: 526 PLGSSSYKSTCQFICDEGYSLSGPERLDCTRS----GRWTDSPPMC----EAIKCPELFA 577
Query: 791 PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIG 850
PE + + T ++ + C+ GF + G + C T W PTC A +
Sbjct: 578 PE-QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLP 636
Query: 851 CP----PPPKTPNGNHTGGNIARFSPGM-----SILYSCDQGYLLVGEALLLCTHEGTWS 901
P P TP G R PG + + C+ G+ L+G++ L C G W+
Sbjct: 637 TPGVQCPALTTPG---QGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWT 693
Query: 902 QPAPHCKEVNCSSPADMDGIQKGLEPR-KMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
P C+ V CS I + YG++ + C +G +L GS Q+ CQ +
Sbjct: 694 AVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGH 753
Query: 961 WNPPLAVCRSRSL 973
W+ + C++ L
Sbjct: 754 WSTTVPTCQAGPL 766
Score = 186 bits (472), Expect = 1e-46
Identities = 159/583 (27%), Positives = 249/583 (42%), Gaps = 71/583 (12%)
Query: 49 YSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYK---IRGS 105
+ C+ +++ G L C+ G W P+C + CP +P + +
Sbjct: 228 FHCTDGYQVNGPSKLECLAS----GIWTNKPPQC----LAAQCPPLKIPERGNMTCLHSA 279
Query: 106 TPYRHGDSVTFACKTNFSMNGNKSVWCQANNMW-GPTRLPTCVSVFPLECPALPMIHNGH 164
++H S +F+C+ F++ G + V C A+ +W P + V LE P+ + H
Sbjct: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339
Query: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNG 224
+ + A G S + C+ GY + G ++ C+ SG WSA PTCE C+ L +G
Sbjct: 340 PLT----AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
Query: 225 KVKEPPILRV---GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPP 280
+ P LR +F C EG+ L+G RC GQ WT PVC+ + C P
Sbjct: 396 SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPAPVCQALQCQDLP 452
Query: 281 PILNGR-HIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPA 339
R + + Y S+ ++TC+ EG+ +L+G S L+C TG W+
Sbjct: 453 VPNEARVNCSHPFGAFRYQSVCSFTCN----EGL--LLVGASVLQCLA----TGNWNSVP 502
Query: 340 PRCELSTSAVQC-PHPQILRGRMVSGQK-DRYTYNDTVIFACMFGFTLKGSKQIRCNAQG 397
P C+ A+ C P G M Q +Y T F C G++L G +++ C G
Sbjct: 503 PECQ----AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG 558
Query: 398 TWEPSAPVCEK----ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC 453
W S P+CE E AP + R F+ G++ +SC+ G+ L G +++C
Sbjct: 559 RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRG--EFNVGSTCHFSCDNGFKLEGPNNVEC 616
Query: 454 TSEGVWTPPVPQCK-VAACEATGRQL--LTKP-------QHQFVRPDVNSSC----GEGY 499
T+ G W+ P CK +A+ G Q LT P +H N++C G+
Sbjct: 617 TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
Query: 500 KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL-EDFPYGTTVTYTCNP 558
L G C+ + W C+ + C V A S+L +F YG+ ++ C
Sbjct: 677 TLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLE 736
Query: 559 GPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQ 601
G L G + C QE G WS P C+ L +Q
Sbjct: 737 GQ------LLNGSAQTAC----QENGHWSTTVPTCQAGPLTIQ 769
Score = 162 bits (410), Expect = 2e-39
Identities = 118/471 (25%), Positives = 193/471 (40%), Gaps = 45/471 (9%)
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+R C E+ P V+ N +H L +F + + ++ C G + + G S + C +
Sbjct: 197 VRECGELELPQH-VLMNCSHP---LGNFSFNSQCSFHCTDG------YQVNGPSKLECLA 246
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP--YFYNDTVTFKCYSGFTL 636
+ G W+ P C LA QC + I ++ + + + + +F C GF L
Sbjct: 247 S----GIWTNKPPQC----LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFAL 298
Query: 637 KGSSQIRCKADNTWDPEIPVCEKETCQHVR-------QSLQELPAGSRVELVNTSCQDGY 689
G ++C A W PVC+ CQH+ + L A + CQ GY
Sbjct: 299 VGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY 358
Query: 690 QLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGK-HTGMMAENFLYGNEVSYEC 748
++ G C D+ G W +P C+ I C P V+G F Y S+ C
Sbjct: 359 RVRGLDMLRCIDS--GHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC 416
Query: 749 DQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTH--SAY 806
+GF L G ++C + G W+ P+P C +C + V + ++N +H A+
Sbjct: 417 AEGFMLRGADIVRCDN----LGQWTAPAPVC----QALQCQDLPVPNEARVNCSHPFGAF 468
Query: 807 SHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGN 866
+ + CN G ++ G+ V++C W P C I C P NG T
Sbjct: 469 RYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC---QAIPCTPLLSPQNGTMTCVQ 525
Query: 867 -IARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP-ADMDGIQKG 924
+ S + + CD+GY L G L CT G W+ P C+ + C A G
Sbjct: 526 PLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDC 585
Query: 925 LEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAP 975
+ R + G+ C++G+ LEG +C + +W+ C+ + P
Sbjct: 586 SDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLP 636
Score = 157 bits (397), Expect = 5e-38
Identities = 126/453 (27%), Positives = 177/453 (39%), Gaps = 56/453 (12%)
Query: 39 TPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPG 98
T A G+ ++ C +R+ G L CI G W P P CE SC EP+
Sbjct: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCID----SGHWSAPLPTCEAI----SC-EPLESP 392
Query: 99 GYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEC 154
+ +P +++ + +F C F + G V C W P C + L+C
Sbjct: 393 VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQW-TAPAPVCQA---LQC 448
Query: 155 PALPMIHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEA 213
LP+ + + S G+ +++C G LLVG ++ CL++G W++VPP C+
Sbjct: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
Query: 214 RCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMP 269
C L NG V+ T F CDEGY L GP C +G+ WT P
Sbjct: 509 PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPP 565
Query: 270 VCEEIFCPSP-PPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328
+CE I CP P ++ + GS ++CD F L G + + CT
Sbjct: 566 MCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN------GFKLEGPNNVECTT- 618
Query: 329 SQKTGTWSGPAPRCE----LSTSAVQCPHPQILRGRMVSGQKDRYT--------YNDTVI 376
+G WS P C+ L T VQCP GQ Y +N T
Sbjct: 619 ---SGRWSATPPTCKGIASLPTPGVQCP------ALTTPGQGTMYCRHHPGTFGFNTTCY 669
Query: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCE--KECQAPPNILNGQKEDRHMVRFDPGTS 434
F C GFTL G + C G W P C K + N F G+
Sbjct: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSI 729
Query: 435 IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCK 467
+ C G +L G C G W+ VP C+
Sbjct: 730 CSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
Score = 130 bits (327), Expect = 6e-30
Identities = 91/358 (25%), Positives = 153/358 (42%), Gaps = 32/358 (8%)
Query: 627 TFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAG--SRVELVNTS 684
T CY GF +R + E+P C H P G S +
Sbjct: 182 TCSCYPGFYGPECEYVR----ECGELELPQHVLMNCSH--------PLGNFSFNSQCSFH 229
Query: 685 CQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM-MAENFLYGNE 743
C DGYQ+ G + C +GIW K P C C P + G T + A+ F + +
Sbjct: 230 CTDGYQVNGPSKLEC--LASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSS 287
Query: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTH 803
S+ C++GF L+G + +QC + G W+ P+P C +C + E ++ H
Sbjct: 288 CSFSCEEGFALVGPEVVQCTAS----GVWTAPAPVC----KAVQCQHLEAPSEGTMDCVH 339
Query: 804 --SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN 861
+A+++ +C PG+ + G ++RC W +PTC I C P +G+
Sbjct: 340 PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC---EAISCEPLESPVHGS 396
Query: 862 -HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMD 919
++ F + + C +G++L G ++ C + G W+ PAP C+ + C P +
Sbjct: 397 MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNE 456
Query: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVL 977
P ++Y +V + C +G +L G+ QC + WN C++ P+L
Sbjct: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 202 bits (513), Expect = 2e-51
Identities = 240/990 (24%), Positives = 390/990 (39%), Gaps = 134/990 (13%)
Query: 23 CGSPPPILNGRI---SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD--K 77
C PP N I S+ GT Y C +R +G ++C G W
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALN 75
Query: 78 PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
P KC+ + P G + + G + +G + C + + G + +
Sbjct: 76 PLRKCQ--KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
Query: 138 WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP---GLSVTYSCESGYLLVGEKI 194
W +P C V +C + NG S + G +V + C SGY + G++
Sbjct: 134 W-TNDIPICEVV---KCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
Query: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254
++C G WS P C E CKS + + I + + C+ GY +
Sbjct: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
Query: 255 RCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C +G W +P CEE C + P I NG + + + + G +TY C G
Sbjct: 250 VCTESG----WRPLPSCEEKSCDN-PYIPNGDYSPLRIKHRT-GDEITYQC----RNGFY 299
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
G +T +CT TG W PAPRC L C +P I G + R +
Sbjct: 300 PATRG-NTAKCT----STG-WI-PAPRCTLK----PCDYPDIKHGGLYHENMRRPYFPVA 348
Query: 375 V----IFACMFGF-TLKGS--KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMV 427
V + C F T GS I C G W P+ P C ++C P + NG ++ H
Sbjct: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKCYF-PYLENGYNQN-HGR 404
Query: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC-KVAACEATGRQL----LTKP 482
+F G SI +C+PGY L ++ E W+ P P+C +V C + + +++
Sbjct: 405 KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISES 463
Query: 483 QHQF-VRPDVNSSCGEGY-----KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
Q+ + ++ C GY + SGS+ C G W + K P ++
Sbjct: 464 QYTYALKEKAKYQCKLGYVTADGETSGSI--TC-GKDGWSAQPTCIKSCDIP----VFMN 516
Query: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCK 594
A T + F T+ Y C+ G E S G +T I C N WS P+C
Sbjct: 517 ARTKNDFTWFKLNDTLDYECHDGYE-----SNTGSTTGSIVCGYNG-----WS-DLPICY 565
Query: 595 LSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
+ VH+ K+ Y + + F C GFT+ G + ++C P++
Sbjct: 566 ERECELPKIDVHLVP----DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDL 620
Query: 655 PVCEK--ETC--------QHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAEN 704
P+C++ ++C +V++ +E S E+V C + + G C D E
Sbjct: 621 PICKEQVQSCGPPPELLNGNVKEKTKEEYGHS--EVVEYYCNPRFLMKGPNKIQCVDGE- 677
Query: 705 GIWFKKIPLCKVIH--CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762
+ +P+C V C P + +G + + + YG+ V + C + F ++G + + C
Sbjct: 678 ---WTTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC 733
Query: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDC--NPGF 820
HG W+ PQC+ + +C + + + K + HN + C G+
Sbjct: 734 I-----HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW 787
Query: 821 IMNGSRVIRCHT---DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSIL 877
I HT + W P V C CPPPP+ PN +H + G +
Sbjct: 788 I---------HTVCINGRWDPEV-NCSMAQIQLCPPPPQIPN-SHNMTTTLNYRDGEKVS 836
Query: 878 YSCDQGYLLVGEALLLCTHEGTWSQPAPHCKE-VNCSSPADMD--GIQKGLEPRKMYQYG 934
C + YL+ + C +G W Q P C E + CS P ++ I ++ Y +G
Sbjct: 837 VLCQENYLIQEGEEITC-KDGRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHG 894
Query: 935 AVVTLECEDGYMLEGSPQSQCQSDHQWNPP 964
++ CE G+ + ++ C +PP
Sbjct: 895 TKLSYTCEGGFRISEENETTCYMGKWSSPP 924
Score = 189 bits (481), Expect = 9e-48
Identities = 229/987 (23%), Positives = 386/987 (39%), Gaps = 136/987 (13%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
SC +P I NG S G I Y C +G + + C + + PAP
Sbjct: 266 SCDNPY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI------PAP 318
Query: 81 KCEYFNKYSSCPEPIVPGG--YKIRGSTPY---RHGDSVTFACKTNFSMNGNKSVWCQAN 135
+C C P + G Y PY G ++ C +F S W +
Sbjct: 319 RCTL----KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSG-SYWDHIH 373
Query: 136 ---NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-G 191
+ W P +P + P + NG++ + G S+ +C GY L
Sbjct: 374 CTQDGWSPA-VPCLRKCY------FPYLENGYNQNHG-RKFVQGKSIDVACHPGYALPKA 425
Query: 192 EKIINCLSSGKWSAVPPTCEEARC-KSLGRFPNGKVKEPPIL-RVGVTANFFCDEGYRLQ 249
+ + C+ +G WS P C KS NG + E + A + C GY
Sbjct: 426 QTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTA 484
Query: 250 GPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
+S + G+ W+ P C I P +N R N + Y C
Sbjct: 485 DGETSGSITCGKD-GWSAQPTC--IKSCDIPVFMNAR-TKNDFTWFKLNDTLDYEC---- 536
Query: 310 EEGVNFILIGESTLRCTVDSQKTGT--WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367
+G ES T S G WS P C +C P+I + +KD
Sbjct: 537 HDGY------ESNTGSTTGSIVCGYNGWSD-LPICYER----ECELPKIDVHLVPDRKKD 585
Query: 368 RYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE---CQAPPNILNGQKEDR 424
+Y + + F+C GFT+ G ++C G P P+C+++ C PP +LNG +++
Sbjct: 586 QYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEK 644
Query: 425 HMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT---------G 475
+ ++Y CNP +++ G IQC +G WT +P C V E+T G
Sbjct: 645 TKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVE--ESTCGDIPELEHG 700
Query: 476 RQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEIT----CPPPP 531
L+ P + + V +C E + + G C + + ++ C I C
Sbjct: 701 WAQLSSPPYYY-GDSVEFNCSESFTMIGHRSITCIHGV--WTQLPQCVAIDKLKKCKSSN 757
Query: 532 VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591
+I H + E F + + + Y C G E + I G W P
Sbjct: 758 LIILEEHLKNKKE-FDHNSNIRYRCR-GKEGWIHTVCIN-------------GRWD-PEV 801
Query: 592 LCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWD 651
C ++ + + I N + ++ Y + V+ C + ++ +I CK D W
Sbjct: 802 NCSMAQIQLCPPPPQIPNSHNMT-TTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ 859
Query: 652 PEIPVC------------EKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC 699
IP+C E T R S + G+++ +C+ G++++ C
Sbjct: 860 -SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSY---TCEGGFRISEENETTC 915
Query: 700 QDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKK 759
G W P C+ + C PP I +G M++++ YG EV+Y+C +GF + G
Sbjct: 916 Y---MGKWSSP-PQCEGLPCKSPPEISHGV-VAHMSDSYQYGEEVTYKCFEGFGIDGPAI 970
Query: 760 LQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPG 819
+C + WS P P C+++ ++ P ++ + + Y + V C
Sbjct: 971 AKCLGEK-----WSHP-PSCIKTDCLSL---PSFENAIPMGEKKDVYKAGEQVTYTCATY 1021
Query: 820 FIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYS 879
+ M+G+ + C ++ W G PTC + C PP N ++++ G + Y
Sbjct: 1022 YKMDGASNVTC-INSRWT-GRPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQ 1076
Query: 880 CDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGAVV 937
C Y + G+ ++C + G W++P P CK+ C P +D P +Y + V
Sbjct: 1077 CRSPYEMFGDEEVMCLN-GNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSV 1134
Query: 938 TLECEDGYMLEGSPQSQCQSDHQWNPP 964
+C++ Y LEG+ + C++ QW+ P
Sbjct: 1135 EYQCQNLYQLEGNKRITCRNG-QWSEP 1160
Score = 151 bits (381), Expect = 3e-36
Identities = 129/503 (25%), Positives = 199/503 (39%), Gaps = 87/503 (17%)
Query: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLL-----------CITKDK 70
+CG P + +G S P G + ++CS +F +IG +S+ C+ DK
Sbjct: 690 TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDK 749
Query: 71 -------------------------------------------VDGTWDKPAPKCEYFNK 87
++G WD P C
Sbjct: 750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD-PEVNCSMAQI 808
Query: 88 YSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCV 147
P P +P + + + YR G+ V+ C+ N+ + + + C+ + W +P CV
Sbjct: 809 QLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRW--QSIPLCV 865
Query: 148 SVFPLECPALPMIHNGHHTSENVG--SIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSA 205
P C P I +G S S A G ++Y+CE G+ + E C GKWS+
Sbjct: 866 EKIP--CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS 922
Query: 206 VPPTCEEARCKSLGRFPNGKVKE-PPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVA 264
PP CE CKS +G V + G + C EG+ + GP ++C+ G
Sbjct: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEK 977
Query: 265 WTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLR 324
W+ P C + C S P N +G G VTYTC + + G S +
Sbjct: 978 WSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVT 1031
Query: 325 CTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFT 384
C ++S+ TG P C TS V P Q +VS Q +Y + V + C +
Sbjct: 1032 C-INSRWTGR-----PTCR-DTSCVNPPTVQ--NAYIVSRQMSKYPSGERVRYQCRSPYE 1082
Query: 385 LKGSKQIRC-NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443
+ G +++ C N T P +C PP I NG + + P +S++Y C Y
Sbjct: 1083 MFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 1142
Query: 444 VLVGEESIQCTSEGVWTPPVPQC 466
L G + I C + G W+ P P+C
Sbjct: 1143 QLEGNKRITCRN-GQWSEP-PKC 1163
Score = 88.2 bits (217), Expect = 4e-17
Identities = 70/261 (26%), Positives = 110/261 (42%), Gaps = 26/261 (9%)
Query: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
P G+ C SPP I +G +++ S G + Y C F + G C+ + W
Sbjct: 924 PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-----KW 978
Query: 76 DKPAPKCEYFNKYS-SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQA 134
P P C + S E +P G K Y+ G+ VT+ C T + M+G +V C
Sbjct: 979 SHP-PSCIKTDCLSLPSFENAIPMGEK---KDVYKAGEQVTYTCATYYKMDGASNVTC-I 1033
Query: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI 194
N+ W T PTC C P + N + S + G V Y C S Y + G++
Sbjct: 1034 NSRW--TGRPTCRDT---SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
Query: 195 INCLSSGKWSAVPPTCEEA--RCKSLGRFPNGKVKEPP--ILRVGVTANFFCDEGYRLQG 250
+ CL +G W+ PP C+++ +C NG + P + + + C Y+L+G
Sbjct: 1089 VMCL-NGNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG 1146
Query: 251 PPSSRCVIAGQGVAWTKMPVC 271
C + W++ P C
Sbjct: 1147 NKRITC----RNGQWSEPPKC 1163
Score = 85.1 bits (209), Expect = 3e-16
Identities = 117/486 (24%), Positives = 174/486 (35%), Gaps = 68/486 (13%)
Query: 522 CKEITCPPPPVIYNGAHTGS-SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
C E+ PP TGS S + +P GT Y C PG + +G + C
Sbjct: 21 CNEL----PPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVC---- 66
Query: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIA--NGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
+G W PL K C H + ++G + Y + C G+ L G
Sbjct: 67 -RKGEWVALNPLRKCQKRP--CGHPGDTPFGTFTLTGGNV-FEYGVKAVYTCNEGYQLLG 122
Query: 639 SSQIR-CKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE---------LVNTSCQDG 688
R C D W +IP+CE C V S +E V C G
Sbjct: 123 EINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSG 181
Query: 689 YQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLY--GNEVSY 746
Y++ G C D +G W K+ P C I C P VI NG +++ +Y Y
Sbjct: 182 YKIEGDEEMHCSD--DGFWSKEKPKCVEISCKSPDVI-NGSP---ISQKIIYKENERFQY 235
Query: 747 ECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAY 806
+C+ G+ + R D+ S P P C C NP + +G + +
Sbjct: 236 KCNMGY------EYSERGDAVCTESGWRPLPSCEEKS----CDNPYIPNG-DYSPLRIKH 284
Query: 807 SHNDIVYVDCNPGFI-MNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGG 865
D + C GF +C T W+P P C K C P G +
Sbjct: 285 RTGDEITYQCRNGFYPATRGNTAKC-TSTGWIPA-PRCTLKP---CDYPDIKHGGLYHEN 339
Query: 866 NIARFSP---GMSILYSCDQGYLLVGEAL---LLCTHEGTWSQPAPHCKEVNCSSPADMD 919
+ P G Y CD+ + + + CT +G WS P ++ C P +
Sbjct: 340 MRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRK--CYFPYLEN 396
Query: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979
G + RK Q G + + C GY L + + ++ W+P R ++ +
Sbjct: 397 GYNQN-HGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSID 454
Query: 980 IAAGLI 985
I G I
Sbjct: 455 IENGFI 460
Score = 74.7 bits (182), Expect = 4e-13
Identities = 64/213 (30%), Positives = 93/213 (43%), Gaps = 24/213 (11%)
Query: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEP-IVPGGYKI 102
G + Y+C+ +++ G ++ CI + W P C + +SC P V Y +
Sbjct: 1011 GEQVTYTCATYYKMDGASNVTCI-----NSRWTG-RPTC----RDTSCVNPPTVQNAYIV 1060
Query: 103 -RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIH 161
R + Y G+ V + C++ + M G++ V C N W T P C +C P I
Sbjct: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNW--TEPPQCKDSTG-KCGPPPPID 1116
Query: 162 NGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRF 221
NG TS + AP SV Y C++ Y L G K I C +G+WS PP C S
Sbjct: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISREIM 1174
Query: 222 PNGKV------KEPPILRVGVTANFFCDEGYRL 248
N + K+ R G + F C GYRL
Sbjct: 1175 ENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL 1207
Score = 47.8 bits (112), Expect = 5e-05
Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%)
Query: 23 CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
CG PPPI NG I+ + + A + + Y C ++L G K + C +G W +P PK
Sbjct: 1109 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWSEP-PK 1162
Query: 82 C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
C E Y+ + + + R G+SV F CK + ++ ++S +
Sbjct: 1163 CLHPCVISREIMENYN------IALRWTAKQKLYSRTGESVEFVCKRGYRLS-SRSHTLR 1215
Query: 134 ANNMWGPTRLPTC 146
G PTC
Sbjct: 1216 TTCWDGKLEYPTC 1228
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 165 bits (417), Expect = 2e-40
Identities = 152/571 (26%), Positives = 247/571 (43%), Gaps = 79/571 (13%)
Query: 23 CGSPPPILNGRIS-YYST------PIAVGTVIRYSCSGTFRLIG---EKSLLCITKDKVD 72
CG P + NGRI+ YY T P+++ + + C + E+ C T+
Sbjct: 25 CGFPH-VENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG--- 80
Query: 73 GTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS--- 129
W P P+C + C +P + GY Y+ +++ + C + + G K
Sbjct: 81 --WS-PEPRC-----FKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEV 132
Query: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHH-TSENVGSIAPGLSVTYSCESGYL 188
V C ++ G + PTC E P ++NG++ T++ + V Y C +GY
Sbjct: 133 VQCLSD---GWSSQPTCRKEH--ETCLAPELYNGNYSTTQKTFKVKD--KVQYECATGYY 185
Query: 189 LVGEKI---INCLSSGKWSAVPPTCEEARCKSLGRFPNG---KVKEPPILRVGVTANFFC 242
G K + CL+ G WS + P C + +C SL NG VK+ G FFC
Sbjct: 186 TAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQT--YEEGDVVQFFC 241
Query: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCE--EIFCPSPPPILNGRHIGNSLANVSYGSI 300
E Y L G +C G + + PVCE CP PP +N + I +G I
Sbjct: 242 HENYYLSGSDLIQCYNFGW---YPESPVCEGRRNRCPPPPLPINSK-IQTHSTTYRHGEI 297
Query: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
V C+ +NF + G + +RC + G W+ P P+C V C P +
Sbjct: 298 VHIECE------LNFEIHGSAEIRC-----EDGKWTEP-PKCIEGQEKVACEEPPFIENG 345
Query: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWE--PSAPVCEKECQAPPNILN 418
+ Y D V +AC G+ L GS +I CN +G W P + C+ PP ++N
Sbjct: 346 AANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNENCKHPPVVMN 404
Query: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC------KVAACE 472
G D + + G+S++Y CN Y+L G + +C +G W+ P P C V
Sbjct: 405 GAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP-PVCLEPCTVNVDYMN 462
Query: 473 ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLS-----GSVYQEC-QGTIPWFMEIRLCKEI 525
++ K + + + D ++ C +GY LS + +C +G + + + R +
Sbjct: 463 RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKG 522
Query: 526 TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC 556
C PP+I +G S+++ + G++V Y C
Sbjct: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
Score = 122 bits (307), Expect = 1e-27
Identities = 145/572 (25%), Positives = 233/572 (40%), Gaps = 86/572 (15%)
Query: 435 IKYSCNPGYVLVG---EESIQCTSEGVWTPPVPQC--KVAACEATGRQLLTKPQHQFVRP 489
+ + C GY EE CT+EG W+P P+C K + + + ++
Sbjct: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPE-PRCFKKCTKPDLSNGYISDVKLLYKIQE 112
Query: 490 DVNSSCGEGYKLSGSVYQECQGTIP--WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
++ C GYK +G +E + W + KE P +YNG ++ ++ + F
Sbjct: 113 NMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYS-TTQKTFK 171
Query: 548 YGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHV 605
V Y C G ++ G+ T + C + WS KL +CS +
Sbjct: 172 VKDKVQYECATG-----YYTAGGKKTEEVECLTYG-----WSLTPKCTKL-----KCSSL 216
Query: 606 H-IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQH 664
I NGY K+ Y D V F C+ + L GS I+C + W PE PVCE +
Sbjct: 217 RLIENGYFHPVKQT-YEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEG---RR 271
Query: 665 VRQSLQELPAGSRV----------ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
R LP S++ E+V+ C+ +++ G A C+D G W + P C
Sbjct: 272 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED---GKWTEP-PKC 327
Query: 715 ----KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHG 770
+ + C PP I NG + ++ + G++V+Y C G+ L G ++ C G
Sbjct: 328 IEGQEKVACEEPPFIENGA-ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-----RG 381
Query: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
W+ P P+C+ + + P P V +G + ++Y+ V CN +++ GS++ RC
Sbjct: 382 KWTLP-PECVENNENCKHP-PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC 439
Query: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFS--------PGMSILYSCDQ 882
P P C++ P T N ++ N G I + C Q
Sbjct: 440 EQGKWSSP--PVCLE---------PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQ 488
Query: 883 GYLL-----VGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGA 935
GY L + E + C + G P KE C+SP + Y+ G+
Sbjct: 489 GYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGS 547
Query: 936 VVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 967
V C D + LEGS ++ C PPL +
Sbjct: 548 SVEYRCFDHHFLEGSREAYCLDGMWTTPPLCL 579
Score = 101 bits (252), Expect = 3e-21
Identities = 137/573 (23%), Positives = 212/573 (36%), Gaps = 86/573 (15%)
Query: 179 VTYSCESGYLLVG---EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPIL-RV 234
+++ C +GY E+ C + G WS P ++ L NG + + +L ++
Sbjct: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPEPRCFKKCTKPDLS---NGYISDVKLLYKI 110
Query: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
+ C GY+ G V+ W+ P C + P L + +
Sbjct: 111 QENMRYGCASGYKTTGGKDEE-VVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKT 169
Query: 295 VSYGSIVTYTCDPDPEEGVNFILIGEST--LRCTVDSQKTGTWSGPAPRCELSTSAVQCP 352
V Y C + G+ T + C T WS P+C + ++C
Sbjct: 170 FKVKDKVQYECATG-----YYTAGGKKTEEVECL-----TYGWS-LTPKC----TKLKCS 214
Query: 353 HPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE---KE 409
+++ K Y D V F C + L GS I+C G W P +PVCE
Sbjct: 215 SLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNR 273
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC--- 466
C PP +N K H + G + C + + G I+C +G WT P P+C
Sbjct: 274 CPPPPLPINS-KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PKCIEG 330
Query: 467 --KVAACEATGRQLLTKPQHQFVRPD---VNSSCGEGYKLSGSVYQECQGTIPWFMEIRL 521
KVA E + H + + V +C GY L GS C W +
Sbjct: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWTLPPEC 389
Query: 522 CKEI-TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
+ C PPV+ NGA L + G++V Y CN + L G RC
Sbjct: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE------YYLLRGSKISRC---- 439
Query: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYNDTVTFKCYSGFTLK-- 637
E+G WS P P+C L V +++ N ++ K E + D + F C G+ L
Sbjct: 440 -EQGKWSSP-PVC-LEPCTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
Query: 638 ---GSSQIRCKADNTWDPEIPVCEKETCQH-------------VRQSLQELPAGSRVELV 681
++C N + + P+C ++ + + ++ GS VE
Sbjct: 496 TPLSELSVQC---NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEY- 551
Query: 682 NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
C D + L G C D G+W PLC
Sbjct: 552 --RCFDHHFLEGSREAYCLD---GMWTTP-PLC 578
Score = 57.8 bits (138), Expect = 5e-08
Identities = 58/271 (21%), Positives = 98/271 (36%), Gaps = 42/271 (15%)
Query: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
++C PP I NG + +S G + Y+C + L G + C G W P P
Sbjct: 334 VACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-----GKWTLP-P 387
Query: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
+C N+ P ++ G Y G SV + C + + G+K C+ P
Sbjct: 388 ECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP 447
Query: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL-----VGEKII 195
P C+ + + +N + G + G + + C+ GY L + E +
Sbjct: 448 ---PVCLEPCTVNVDYMNR-NNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
Query: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV-------------TANFFC 242
C + P C K G PP+++ GV + + C
Sbjct: 504 QC---NRGEVKYPLCTRKESK-------GMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
Query: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCEE 273
+ + L+G + C+ WT P+C E
Sbjct: 554 FDHHFLEGSREAYCLDG----MWTTPPLCLE 580
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 159 bits (401), Expect = 2e-38
Identities = 129/453 (28%), Positives = 196/453 (43%), Gaps = 48/453 (10%)
Query: 115 TFACKTNFSMNGN-------KSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS 167
T AC TN S +G+ + C+ + + + V+ LE P H S
Sbjct: 140 TAAC-TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPE----HGSLVCS 194
Query: 168 ENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV- 226
+G+ + S + SC+ GYL + + C+SSG+WSA P C C ++ NG V
Sbjct: 195 HPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVE 254
Query: 227 --KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPIL 283
+ P T F C+EG+ L G S +C +G W + P C+ + C +
Sbjct: 255 CFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQ 311
Query: 284 NG--RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341
NG R + ++ S +TC EEG F+L G + + CT G W+ P
Sbjct: 312 NGSVRCSHSPAGEFTFKSSCNFTC----EEG--FMLQGPAQVECTTQ----GQWTQQIPV 361
Query: 342 CELSTSAVQC---PHPQILRGRM--VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQ 396
CE A QC +P+ RG M + + Y + F+C GF LKGSK+++C
Sbjct: 362 CE----AFQCTALSNPE--RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT 415
Query: 397 GTWEPSAPVCEK-ECQAPPNILNGQKEDRH--MVRFDPGTSIKYSCNPGYVLVGEESIQC 453
G W+ P CE C A G H + F +S +SC G+ L G ++C
Sbjct: 416 GEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC 475
Query: 454 TSEGVWTPPVPQCKVAACEA---TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
TS+G WT VP C+V C + G+ ++ +C EG+ L+GS + C
Sbjct: 476 TSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCG 535
Query: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL 543
T W + C+ T P++ + G SL
Sbjct: 536 ATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSL 568
Score = 148 bits (373), Expect = 3e-35
Identities = 105/375 (28%), Positives = 163/375 (43%), Gaps = 51/375 (13%)
Query: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR 488
F +S SC+ GY+ E++QC S G W+ P+P C V C+A +T P + FV
Sbjct: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDA-----VTNPANGFVE 254
Query: 489 PDVNS-----------SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA 537
N C EG++L G+ +C + W E CK +TC NG+
Sbjct: 255 CFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGS 314
Query: 538 --HTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL 595
+ S +F + ++ +TC G F L G + + CT+ +G W+ P+C+
Sbjct: 315 VRCSHSPAGEFTFKSSCNFTCEEG------FMLQGPAQVECTT----QGQWTQQIPVCE- 363
Query: 596 SLLAVQCSHV-HIANGYK--ISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDP 652
A QC+ + + GY + + Y + F C GF LKGS +++C WD
Sbjct: 364 ---AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
Query: 653 EIPVCEKETCQHVRQSLQEL------PAGSRVELVNT--SCQDGYQLTGHAYQMCQDAEN 704
E P CE C V Q + L P G + SC++G++L G C
Sbjct: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC--TSQ 478
Query: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 764
G W +++P C+V+ C + V GK + ++G + C +G+ L G C +
Sbjct: 479 GQWTEEVPSCQVVKC--SSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGA 536
Query: 765 DSKGHGSWSGPSPQC 779
G WSG P C
Sbjct: 537 T----GHWSGLLPTC 547
Score = 144 bits (363), Expect = 4e-34
Identities = 110/394 (27%), Positives = 170/394 (43%), Gaps = 70/394 (17%)
Query: 543 LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602
L +F Y ++ + +C+ G + T++C S+ G WS P P C + V+C
Sbjct: 197 LGNFSYNSSCSISCDRG------YLPSSMETMQCMSS----GEWSAPIPACNV----VEC 242
Query: 603 SHV-HIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE 660
V + ANG+ + F +N T TF C GF L G+ ++C + WD E P C+
Sbjct: 243 DAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAV 302
Query: 661 TCQHVRQ------SLQELPAGSRV--ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
TC+ VRQ PAG N +C++G+ L G A C G W ++IP
Sbjct: 303 TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVEC--TTQGQWTQQIP 360
Query: 713 LCKVIHCHPPPVIVNGKHTGMM------AENFLYGNEVSYECDQGFYLLGEKKLQCRSDS 766
+C+ C ++ G M + +F YG+ + C+QGF L G K+LQC
Sbjct: 361 VCEAFQC----TALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT- 415
Query: 767 KGHGSWSGPSPQC-------LRSPP--VTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCN 817
G W P C + PP + RC + + G K+ A+S C
Sbjct: 416 ---GEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPI--GEFTYKSSCAFS--------CE 462
Query: 818 PGFIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGCPPP-PKTPNGNHTGGNIARFSPGM 874
GF ++GS + C + W VP+C +K + + P + +G G + +F
Sbjct: 463 EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKF---- 518
Query: 875 SILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908
+C +G+ L G A C G WS P C+
Sbjct: 519 ----ACPEGWTLNGSAARTCGATGHWSGLLPTCE 548
Score = 143 bits (361), Expect = 7e-34
Identities = 103/388 (26%), Positives = 162/388 (41%), Gaps = 36/388 (9%)
Query: 620 YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE 679
+ YN + + C G+ ++C + W IP C C V PA VE
Sbjct: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTN-----PANGFVE 254
Query: 680 LV--------NTSC----QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVN 727
NT+C ++G++L G Q Q +G W + P CK + C N
Sbjct: 255 CFQNPGSFPWNTTCTFDCEEGFELMGA--QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQN 312
Query: 728 G--KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPV 785
G + + A F + + ++ C++GF L G +++C + G W+ P C +
Sbjct: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ----GQWTQQIPVC-EAFQC 367
Query: 786 TRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIK 845
T NPE + L ++ + C GF++ GS+ ++C W PTC
Sbjct: 368 TALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC-- 425
Query: 846 KAFIGCPPPPKTPNG--NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQP 903
+ C + P G I F+ S +SC++G+ L G L CT +G W++
Sbjct: 426 -EAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEE 484
Query: 904 APHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNP 963
P C+ V CSS A I + +G V C +G+ L GS C + W+
Sbjct: 485 VPSCQVVKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWTLNGSAARTCGATGHWSG 542
Query: 964 PLAVCR--SRSLAPVLCGI-AAGLILLT 988
L C + S P++ G+ AAGL LLT
Sbjct: 543 LLPTCEAPTESNIPLVAGLSAAGLSLLT 570
Score = 115 bits (289), Expect = 2e-25
Identities = 95/343 (27%), Positives = 140/343 (40%), Gaps = 44/343 (12%)
Query: 21 ISCGSPPPILNGRISYYSTPIAV--GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKP 78
+ C + NG + + P + T + C F L+G +SL C + G WD
Sbjct: 240 VECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSS----GNWDNE 295
Query: 79 APKCEYFNKYSSCPEPIVPGGYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQA 134
P C K +C P +R S + S F C+ F + G V C
Sbjct: 296 KPTC----KAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
Query: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS--ENVGSIAPGLSVTYSCESGYLLVGE 192
W ++P C + +C AL G+ GS G S +SCE G++L G
Sbjct: 352 QGQW-TQQIPVCEA---FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGS 407
Query: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVK--EPPI--LRVGVTANFFCDEGYRL 248
K + C +G+W PTCE RC ++ + P G V+ PI + F C+EG+ L
Sbjct: 408 KRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFEL 467
Query: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPS--PPPILNGRHIGNSLANVSYGSIVTYTC 305
G C GQ WT ++P C+ + C S P +N G + +G++ + C
Sbjct: 468 HGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC 520
Query: 306 DPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
PE + L G + C TG WSG P CE T +
Sbjct: 521 ---PE---GWTLNGSAARTCGA----TGHWSGLLPTCEAPTES 553
Score = 62.4 bits (150), Expect = 2e-09
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 1/105 (0%)
Query: 867 IARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPAD-MDGIQKGL 925
+ FS S SCD+GYL + C G WS P P C V C + + +G +
Sbjct: 197 LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECF 256
Query: 926 EPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRS 970
+ + + T +CE+G+ L G+ QC S W+ C++
Sbjct: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKA 301
Score = 33.5 bits (75), Expect = 1.1
Identities = 11/42 (26%), Positives = 20/42 (47%)
Query: 927 PRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVC 968
P + Y + ++ C+ GY+ QC S +W+ P+ C
Sbjct: 196 PLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 139 bits (351), Expect = 1e-32
Identities = 90/279 (32%), Positives = 130/279 (46%), Gaps = 21/279 (7%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSR 677
S I C +++TWDP +P C K + +S +G R
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 131 bits (329), Expect = 4e-30
Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K + K+P + +G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQCKVAACEAT 474
W PPVP+C + +T
Sbjct: 276 WDPPVPKCLKVSTSST 291
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +V+
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
Query: 912 CSS 914
SS
Sbjct: 288 TSS 290
Score = 66.2 bits (160), Expect = 1e-10
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 15/206 (7%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTCEEARCKSLGRFPNGKVKEP 229
P C + S + P P
Sbjct: 277 DPPVPKCLKVSTSSTTKSPASSASGP 302
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 27 PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
P + NG+ IS + + + C F L G +++C + + TWD P PKC
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
Query: 86 NKYSSCPEP 94
+ S+ P
Sbjct: 287 STSSTTKSP 295
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 139 bits (351), Expect = 1e-32
Identities = 90/279 (32%), Positives = 130/279 (46%), Gaps = 21/279 (7%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSR 677
S I C +++TWDP +P C K + +S +G R
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 131 bits (329), Expect = 4e-30
Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K + K+P + +G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQCKVAACEAT 474
W PPVP+C + +T
Sbjct: 276 WDPPVPKCLKVSTSST 291
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +V+
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
Query: 912 CSS 914
SS
Sbjct: 288 TSS 290
Score = 66.2 bits (160), Expect = 1e-10
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 15/206 (7%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTCEEARCKSLGRFPNGKVKEP 229
P C + S + P P
Sbjct: 277 DPPVPKCLKVSTSSTTKSPASSASGP 302
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 27 PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
P + NG+ IS + + + C F L G +++C + + TWD P PKC
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
Query: 86 NKYSSCPEP 94
+ S+ P
Sbjct: 287 STSSTTKSP 295
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 139 bits (351), Expect = 1e-32
Identities = 90/279 (32%), Positives = 130/279 (46%), Gaps = 21/279 (7%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSR 677
S I C +++TWDP +P C K + +S +G R
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 131 bits (329), Expect = 4e-30
Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K + K+P + +G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQCKVAACEAT 474
W PPVP+C + +T
Sbjct: 276 WDPPVPKCLKVSTSST 291
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +V+
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
Query: 912 CSS 914
SS
Sbjct: 288 TSS 290
Score = 66.2 bits (160), Expect = 1e-10
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 15/206 (7%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTCEEARCKSLGRFPNGKVKEP 229
P C + S + P P
Sbjct: 277 DPPVPKCLKVSTSSTTKSPASSASGP 302
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 27 PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
P + NG+ IS + + + C F L G +++C + + TWD P PKC
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
Query: 86 NKYSSCPEP 94
+ S+ P
Sbjct: 287 STSSTTKSP 295
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 138 bits (347), Expect = 3e-32
Identities = 88/270 (32%), Positives = 127/270 (47%), Gaps = 21/270 (7%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQS 668
S I C +++TWDP +P C K + +S
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Score = 131 bits (329), Expect = 4e-30
Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K + K+P + +G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQCKVAACEAT 474
W PPVP+C + +T
Sbjct: 276 WDPPVPKCLKVSTSST 291
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +V+
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
Query: 912 CSS 914
SS
Sbjct: 288 TSS 290
Score = 65.5 bits (158), Expect = 3e-10
Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 15/213 (7%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV 236
P C + S + P P G+
Sbjct: 277 DPPVPKCLKVSTSSTTKSPASSASGYPKPEEGI 309
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 27 PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
P + NG+ IS + + + C F L G +++C + + TWD P PKC
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
Query: 86 NKYSSCPEP 94
+ S+ P
Sbjct: 287 STSSTTKSP 295
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 138 bits (347), Expect = 3e-32
Identities = 88/270 (32%), Positives = 127/270 (47%), Gaps = 21/270 (7%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEKETCQHVRQS 668
S I C +++TWDP +P C K + +S
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Score = 131 bits (329), Expect = 4e-30
Identities = 84/278 (30%), Positives = 132/278 (47%), Gaps = 26/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K + K+P + +G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK---VSTSSTTKSPASSASG 301
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/256 (26%), Positives = 109/256 (42%), Gaps = 21/256 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQCKVAACEAT 474
W PPVP+C + +T
Sbjct: 276 WDPPVPKCLKVSTSST 291
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 19/183 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +V+
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287
Query: 912 CSS 914
SS
Sbjct: 288 TSS 290
Score = 65.5 bits (158), Expect = 3e-10
Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 15/213 (7%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFACKTN-----FSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA- 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV 236
P C + S + P P G+
Sbjct: 277 DPPVPKCLKVSTSSTTKSPASSASGYPKPEEGI 309
Score = 33.9 bits (76), Expect = 0.81
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 5/69 (7%)
Query: 27 PPILNGR-ISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
P + NG+ IS + + + C F L G +++C + + TWD P PKC
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKV 286
Query: 86 NKYSSCPEP 94
+ S+ P
Sbjct: 287 STSSTTKSP 295
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (333), Expect = 1e-30
Identities = 81/243 (33%), Positives = 115/243 (47%), Gaps = 14/243 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC 410
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287
Query: 411 QAP 413
P
Sbjct: 288 PKP 290
Score = 131 bits (330), Expect = 3e-30
Identities = 84/268 (31%), Positives = 128/268 (47%), Gaps = 27/268 (10%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPP 854
I C +++TW P VP C+K G P P
Sbjct: 267 TIVCDSNSTWDPPVPKCLK----GYPKP 290
Score = 112 bits (281), Expect = 1e-24
Identities = 81/317 (25%), Positives = 125/317 (39%), Gaps = 30/317 (9%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVCRSRSLAP-----------VLCGIAAGLILLTFLIVITLYVIS 999
C S+ W+PP+ C P V+ I +++ +I + Y
Sbjct: 266 DTIVCDSNSTWDPPVPKCLKGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYL 325
Query: 1000 KHRAR--NYYTDTSQKE 1014
+ R + Y TD + +E
Sbjct: 326 QRRKKKGTYLTDETHRE 342
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Score = 61.6 bits (148), Expect = 4e-09
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFP 151
+N+ W P +P C+ +P
Sbjct: 272 SNSTWDPP-VPKCLKGYP 288
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 131 bits (329), Expect = 4e-30
Identities = 83/269 (30%), Positives = 127/269 (47%), Gaps = 23/269 (8%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
I C +++TW P VP C+K PP
Sbjct: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKT 802
P P+CL+ P + P + H + T
Sbjct: 279 PVPKCLKVLPPSSTKPPALSHSVSTSST 306
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 85.1 bits (209), Expect = 3e-16
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 67.8 bits (164), Expect = 5e-11
Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 16/175 (9%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYL 188
+N+ W P +P C+ V P P + + TS S A S E G L
Sbjct: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGIL 325
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 134 bits (338), Expect = 3e-31
Identities = 87/278 (31%), Positives = 132/278 (47%), Gaps = 27/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K G P K P N+ G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK----GPRPTYKPPVSNYPG 300
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 92.0 bits (227), Expect = 3e-18
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 25/203 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGY 797
P P+CL+ P T P GY
Sbjct: 279 PVPKCLKGPRPTYKPPVSNYPGY 301
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCV 147
+N+ W P +P C+
Sbjct: 272 SNSTWDPP-VPKCL 284
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 134 bits (338), Expect = 3e-31
Identities = 87/278 (31%), Positives = 132/278 (47%), Gaps = 27/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K G P K P N+ G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK----GPRPTYKPPVSNYPG 300
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 92.0 bits (227), Expect = 3e-18
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 25/203 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGY 797
P P+CL+ P T P GY
Sbjct: 279 PVPKCLKGPRPTYKPPVSNYPGY 301
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCV 147
+N+ W P +P C+
Sbjct: 272 SNSTWDPP-VPKCL 284
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 134 bits (338), Expect = 3e-31
Identities = 87/278 (31%), Positives = 132/278 (47%), Gaps = 27/278 (9%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 864
I C +++TW P VP C+K G P K P N+ G
Sbjct: 267 TIVCDSNSTWDPPVPKCLK----GPRPTYKPPVSNYPG 300
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 92.0 bits (227), Expect = 3e-18
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 25/203 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGY 797
P P+CL+ P T P GY
Sbjct: 279 PVPKCLKGPRPTYKPPVSNYPGY 301
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCV 147
+N+ W P +P C+
Sbjct: 272 SNSTWDPP-VPKCL 284
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 131 bits (329), Expect = 4e-30
Identities = 83/269 (30%), Positives = 127/269 (47%), Gaps = 23/269 (8%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
I C +++TW P VP C+K PP
Sbjct: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKT 802
P P+CL+ P + P + H + T
Sbjct: 279 PVPKCLKVLPPSSTKPPALSHSVSTSST 306
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 85.1 bits (209), Expect = 3e-16
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 67.0 bits (162), Expect = 9e-11
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 19/171 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFP---LECPALPMIHNGHHTSENVGSIAPGLSVTY 181
+N+ W P +P C+ V P + PAL + T+++ S A G TY
Sbjct: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTY 321
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (333), Expect = 1e-30
Identities = 81/243 (33%), Positives = 115/243 (47%), Gaps = 14/243 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC 410
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287
Query: 411 QAP 413
P
Sbjct: 288 PKP 290
Score = 131 bits (330), Expect = 3e-30
Identities = 84/268 (31%), Positives = 128/268 (47%), Gaps = 27/268 (10%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPP 854
I C +++TW P VP C+K G P P
Sbjct: 267 TIVCDSNSTWDPPVPKCLK----GYPKP 290
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 84.3 bits (207), Expect = 5e-16
Identities = 54/195 (27%), Positives = 88/195 (45%), Gaps = 22/195 (11%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
P NG G +F ++++ CD+G+ L G ++C TW P P C +
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK-- 285
Query: 912 CSSPADMDGIQKGLE 926
P +GI L+
Sbjct: 286 -GYPKPEEGILDSLD 299
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Score = 61.6 bits (148), Expect = 4e-09
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFP 151
+N+ W P +P C+ +P
Sbjct: 272 SNSTWDPP-VPKCLKGYP 288
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 131 bits (329), Expect = 4e-30
Identities = 83/269 (30%), Positives = 127/269 (47%), Gaps = 23/269 (8%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
I C +++TW P VP C+K PP
Sbjct: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKT 802
P P+CL+ P + P + H + T
Sbjct: 279 PVPKCLKVLPPSSTKPPALSHSVSTSST 306
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 85.1 bits (209), Expect = 3e-16
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 67.8 bits (164), Expect = 5e-11
Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 16/175 (9%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYL 188
+N+ W P +P C+ V P P + + TS S A S E G L
Sbjct: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGIL 325
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 137 bits (346), Expect = 4e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
Query: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
Query: 639 SSQIRCKADNTWDPEIPVCEK 659
S I C +++TWDP +P C K
Sbjct: 265 SDTIVCDSNSTWDPPVPKCLK 285
Score = 132 bits (332), Expect = 2e-30
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
Query: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
Query: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
Query: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 131 bits (329), Expect = 4e-30
Identities = 83/269 (30%), Positives = 127/269 (47%), Gaps = 23/269 (8%)
Query: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
I C +++TW P VP C+K PP
Sbjct: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
Score = 111 bits (277), Expect = 4e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
C PP + G + G V Y+C +G++ + D + H
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
Query: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
Query: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
Query: 951 PQSQCQSDHQWNPPLAVC 968
C S+ W+PP+ C
Sbjct: 266 DTIVCDSNSTWDPPVPKC 283
Score = 93.2 bits (230), Expect = 1e-18
Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
Query: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
Query: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
Query: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKT 802
P P+CL+ P + P + H + T
Sbjct: 279 PVPKCLKVLPPSSTKPPALSHSVSTSST 306
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
Query: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
Query: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
Query: 459 WTPPVPQC 466
W PPVP+C
Sbjct: 276 WDPPVPKC 283
Score = 85.1 bits (209), Expect = 3e-16
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
Query: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
Query: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 80.9 bits (198), Expect = 6e-15
Identities = 70/268 (26%), Positives = 104/268 (38%), Gaps = 33/268 (12%)
Query: 90 SCPEPIVPGGYKIRGSTP--YRHGDSVTFACKTNFSMNGNKSVW--CQANNMWGPTRLPT 145
+C EP ++ G Y G+ V + CK + + C N+ W P
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--- 202
C + CP + NG N G+ G + + C GY L+GE+I+ C G
Sbjct: 94 C---YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
Query: 203 WSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCD-----EGYRLQGPPSSR 255
WS PP CE+ C + NGK E + + CD + + L G +
Sbjct: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
Query: 256 CVIAGQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
C G W++ P C+ + C P + NG+ I Y + V + CD
Sbjct: 210 C---GDNSVWSRAAPECKVVKCRF-PVVENGKQISGFGKKFYYKATVMFECDK------G 259
Query: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
F L G T+ C +S TW P P+C
Sbjct: 260 FYLDGSDTIVCDSNS----TWDPPVPKC 283
Score = 67.0 bits (162), Expect = 9e-11
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 19/171 (11%)
Query: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
Query: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
Query: 134 ANNMWGPTRLPTCVSVFP---LECPALPMIHNGHHTSENVGSIAPGLSVTY 181
+N+ W P +P C+ V P + PAL + T+++ S A G TY
Sbjct: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTY 321
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
Query: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
Query: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 204 SAVPPTC 210
P C
Sbjct: 277 DPPVPKC 283
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,494,136
Number of Sequences: 37866
Number of extensions: 2891685
Number of successful extensions: 11687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 5791
Number of HSP's gapped (non-prelim): 1729
length of query: 1033
length of database: 18,247,518
effective HSP length: 112
effective length of query: 921
effective length of database: 14,006,526
effective search space: 12900010446
effective search space used: 12900010446
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.