Guide to the Human Genome
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Search of human proteins with 41872500

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
         (735 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]        1517   0.0  
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]        1517   0.0  
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]        1517   0.0  
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]        1517   0.0  
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]      885   0.0  
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]      850   0.0  
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]     786   0.0  
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]     742   0.0  
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]     724   0.0  
gi|4758156 diacylglycerol kinase, iota [Homo sapiens]                 286   4e-77
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]       279   6e-75
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]       279   6e-75
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]      279   8e-75
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]       279   8e-75
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]               276   5e-74
gi|40806175 diacylglycerol kinase, theta [Homo sapiens]               228   2e-59
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ...   206   8e-53
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ...   206   8e-53
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]       205   1e-52
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]       205   1e-52
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                191   2e-48
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...    57   5e-08
gi|13384594 protein kinase C, gamma [Homo sapiens]                     52   2e-06
gi|47157325 protein kinase C, delta [Homo sapiens]                     48   3e-05
gi|31377782 protein kinase C, delta [Homo sapiens]                     48   3e-05
gi|28557781 protein kinase C, eta [Homo sapiens]                       48   4e-05
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            47   5e-05
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            47   5e-05
gi|5453976 protein kinase C, theta [Homo sapiens]                      47   5e-05
gi|4506067 protein kinase C, alpha [Homo sapiens]                      46   1e-04

>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 1517 bits (3928), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
           MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60

Query: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
           LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120

Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
           LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180

Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
           VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240

Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
           TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300

Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
           VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360

Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
           STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420

Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
           FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480

Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
           NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540

Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
           REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600

Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
           NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660

Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
           GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720

Query: 721 MGPPPRSTNFFGFLS 735
           MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735


>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 1517 bits (3928), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
           MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60

Query: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
           LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120

Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
           LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180

Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
           VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240

Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
           TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300

Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
           VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360

Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
           STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420

Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
           FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480

Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
           NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540

Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
           REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600

Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
           NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660

Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
           GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720

Query: 721 MGPPPRSTNFFGFLS 735
           MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735


>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 1517 bits (3928), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
           MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60

Query: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
           LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120

Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
           LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180

Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
           VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240

Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
           TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300

Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
           VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360

Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
           STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420

Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
           FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480

Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
           NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540

Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
           REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600

Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
           NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660

Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
           GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720

Query: 721 MGPPPRSTNFFGFLS 735
           MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735


>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 1517 bits (3928), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60
           MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
Sbjct: 1   MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY 60

Query: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120
           LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
Sbjct: 61  LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK 120

Query: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180
           LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
Sbjct: 121 LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW 180

Query: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240
           VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
Sbjct: 181 VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY 240

Query: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300
           TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
Sbjct: 241 TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC 300

Query: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360
           VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
Sbjct: 301 VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL 360

Query: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420
           STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
Sbjct: 361 STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL 420

Query: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480
           FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
Sbjct: 421 FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ 480

Query: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540
           NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
Sbjct: 481 NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM 540

Query: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600
           REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
Sbjct: 541 REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL 600

Query: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660
           NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
Sbjct: 601 NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE 660

Query: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
           GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
Sbjct: 661 GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720

Query: 721 MGPPPRSTNFFGFLS 735
           MGPPPRSTNFFGFLS
Sbjct: 721 MGPPPRSTNFFGFLS 735


>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
          Length = 804

 Score =  885 bits (2287), Expect = 0.0
 Identities = 446/788 (56%), Positives = 554/788 (70%), Gaps = 71/788 (9%)

Query: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69

Query: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128

Query: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188

Query: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248

Query: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308

Query: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367

Query: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427

Query: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487

Query: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547

Query: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607

Query: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667

Query: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723

Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMG 722
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCTIKITHKNQ PMLMG
Sbjct: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMG 783

Query: 723 PPPRSTNF 730
           PPP++  F
Sbjct: 784 PPPKTGLF 791


>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
          Length = 773

 Score =  850 bits (2197), Expect = 0.0
 Identities = 429/767 (55%), Positives = 536/767 (69%), Gaps = 71/767 (9%)

Query: 8   ISPSDFAQLQKYMEYSTKKVSDVLKLFE-DGEMAKY-------VQGDAIGYEGFQQFLKI 59
           +SPS+F+QLQKY EYSTKK+ DVL+ F  +G +AKY       +    I +EGF+ F+K 
Sbjct: 10  LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKT 69

Query: 60  YLEVDNVPRHLSLALFQSFET------------------GHCLNETNVTK---------- 91
           +LE + +P   +  LF SF                    G  +N+  +T           
Sbjct: 70  FLEAE-LPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTC 128

Query: 92  --DVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYL 149
             +V+ L D+ CY SLLE GRPEDKLEF F+LYDTD NG LDSSE++ II QMM VAEYL
Sbjct: 129 SPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYL 188

Query: 150 DWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWR 209
           +WDV+EL PIL EMM+EIDYD  G+VS  EW++ G TT+PLLVLLGLE  +KDDGQH+WR
Sbjct: 189 EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWR 248

Query: 210 PKRFPRPVYCNLCESS-IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQ 268
            K F +P YCNLC +  IG+GKQGL C+ CKYTVH++C  +A P  + TY KS+++  V 
Sbjct: 249 LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVM 308

Query: 269 SHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHI 328
            H WV G C + +CD+C K ++ Y  LTGLHCVWC + +H+ C   +  ECDCG L+DHI
Sbjct: 309 HHYWVEGNCPT-KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHI 367

Query: 329 LPPSSIYPSVLASGP----------------DRKNSKTSQKTMDDLNLSTSEALRID--- 369
           LPP++I P VL + P                ++  S+   K +D   +  + ++ +D   
Sbjct: 368 LPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQG 427

Query: 370 ----PVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP 425
               PVP THPLLVFVNPKSGGKQG+R+  KFQY+LNPRQV++L  +GP  GL  F+DVP
Sbjct: 428 LQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP 487

Query: 426 DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKI 485
           D R+L CGGDGTVGW+L+ I+KAN+   PPVA+LPLGTGNDLARCLRWGGGYEG+NL KI
Sbjct: 488 DFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKI 547

Query: 486 LKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYP 545
           LKD+E S  + +DRW  EVIP   +EK DPVP+ IINNYFSIGVDASIAHRFHIMREK+P
Sbjct: 548 LKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHP 607

Query: 546 EKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSM 605
           EKFNSRMKNK WYFEF TSE+  +TCKKL ES+ +E  G  +DL N+SLEGIA+LNIPSM
Sbjct: 608 EKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSM 667

Query: 606 HGGSNLWGDT--RRPHGDIYGINQALGATAK-VITDPDILKTCVPDLSDKRLEVVGLEGA 662
           HGGSNLWG++  RR H  I    +  G+  +  +TD   LK    DLSD+ LEVVGLEGA
Sbjct: 668 HGGSNLWGESKKRRSHRRI----EKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGA 723

Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTI 709
           +EMGQIYT LK+AGRRLA+CS +   T+K+LPMQIDGEPWMQTPCT+
Sbjct: 724 MEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770


>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
          Length = 791

 Score =  786 bits (2029), Expect = 0.0
 Identities = 411/798 (51%), Positives = 519/798 (65%), Gaps = 85/798 (10%)

Query: 1   MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
           M +ER + ++P +F QLQKY EYS+KK+ D L  F E G + +Y   + I Y+ F+ F++
Sbjct: 1   MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60

Query: 59  --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
                         ++L     PRH          S +   S +T +  N  N TK    
Sbjct: 61  AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119

Query: 92  -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
                                                 VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179

Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
           LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD  G 
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239

Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
           VS  EWV  G TT+PLLVLLG++ +  K DG+H W  K F +P YCN C   + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299

Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
           L C  CKYTVH++C  + +P  V TY+K+++   V  H WV G   S +CDRC K I+ Y
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358

Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
            S+T  HCVWC +  H  C   +   CD G LRDHIL P+SI P       ++ +   S 
Sbjct: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416

Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
           K   +L +      +I P P THPLLV VNPKSGG+QG+R+L KF Y+LNP+QVFNL   
Sbjct: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNG 470

Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
           GP  GL  F+D PD R+L CGGDGTVGWIL+ IDKAN    PPVAVLPLGTGNDLARCLR
Sbjct: 471 GPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 530

Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
           WGGGYEG +L KILKD+E S +V +DRW +EVIP++  E  D VP+ I+NNYFSIGVDAS
Sbjct: 531 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 590

Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
           IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+  +TCKKL + + +E  G  +DLSN+
Sbjct: 591 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 650

Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
            LEGIA+LNIPSM+GG+NLWG+ ++           +  + K +TDP  LK CV DLSD+
Sbjct: 651 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 703

Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
            LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T  T K LPMQ+DGEPWMQ  CTIKIT
Sbjct: 704 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 763

Query: 713 HKNQMPMLMGPPPRSTNF 730
           HKNQ PM+MGPP +S+ F
Sbjct: 764 HKNQAPMMMGPPQKSSFF 781


>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
          Length = 766

 Score =  742 bits (1915), Expect = 0.0
 Identities = 396/798 (49%), Positives = 501/798 (62%), Gaps = 110/798 (13%)

Query: 1   MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
           M +ER + ++P +F QLQKY EYS+KK+ D L  F E G + +Y   + I Y+ F+ F++
Sbjct: 1   MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60

Query: 59  --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
                         ++L     PRH          S +   S +T +  N  N TK    
Sbjct: 61  AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119

Query: 92  -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
                                                 VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179

Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
           LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD  G 
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239

Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
           VS  EWV  G TT+PLLVLLG++ +  K DG+H W  K F +P YCN C   + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299

Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
           L C  CKYTVH++C  + +P  V TY+K+++   V  H WV G   S +CDRC K I+ Y
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY 358

Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
            S+T  HCVWC +  H  C   +   CD G LRDHIL P+SI P       ++ +   S 
Sbjct: 359 QSVTARHCVWCRMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 416

Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
           K   +L +      +I P P THPLLV VNPKSGG+QG+R                    
Sbjct: 417 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGER-------------------- 450

Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
                L  F+D PD R+L CGGDGTVGWIL+ IDKAN    PPVAVLPLGTGNDLARCLR
Sbjct: 451 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 505

Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
           WGGGYEG +L KILKD+E S +V +DRW +EVIP++  E  D VP+ I+NNYFSIGVDAS
Sbjct: 506 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 565

Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
           IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+  +TCKKL + + +E  G  +DLSN+
Sbjct: 566 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 625

Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
            LEGIA+LNIPSM+GG+NLWG+ ++           +  + K +TDP  LK CV DLSD+
Sbjct: 626 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 678

Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
            LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T  T K LPMQ+DGEPWMQ  CTIKIT
Sbjct: 679 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 738

Query: 713 HKNQMPMLMGPPPRSTNF 730
           HKNQ PM+MGPP +S+ F
Sbjct: 739 HKNQAPMMMGPPQKSSFF 756


>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
          Length = 752

 Score =  724 bits (1868), Expect = 0.0
 Identities = 394/798 (49%), Positives = 498/798 (62%), Gaps = 124/798 (15%)

Query: 1   MAKERGL-ISPSDFAQLQKYMEYSTKKVSDVLKLF-EDGEMAKYVQGDAIGYEGFQQFLK 58
           M +ER + ++P +F QLQKY EYS+KK+ D L  F E G + +Y   + I Y+ F+ F++
Sbjct: 1   MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR 60

Query: 59  --------------IYLEVDNVPRH---------LSLALFQSFETGHCLNETNVTK---- 91
                         ++L     PRH          S +   S +T +  N  N TK    
Sbjct: 61  AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADT-NIQNADNATKADEA 119

Query: 92  -------------------------------------DVVCLNDVSCYFSLLEGGRPEDK 114
                                                 VV L DV CY SLLE GRP+DK
Sbjct: 120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDK 179

Query: 115 LEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGS 174
           LEF F+LYD+D NG+LD +E+D I+ QM+ +A+YL+WD +ELRPIL+EM++ +DYD  G 
Sbjct: 180 LEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239

Query: 175 VSQAEWVRAGATTVPLLVLLGLEMT-LKDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQG 232
           VS  EWV  G TT+PLLVLLG++ +  K DG+H W  K F +P YCN C   + G+ KQG
Sbjct: 240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQG 299

Query: 233 LSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIY 292
           L C  CKYTVH++C  + +P  V TY+K+++               SG            
Sbjct: 300 LCCTYCKYTVHERCVSRNIPGCVKTYSKAKR---------------SG------------ 332

Query: 293 HSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQ 352
                        E H  C   +   CD G LRDHIL P+SI P       ++ +   S 
Sbjct: 333 -------------EFHRKC--ELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSA 377

Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
           K   +L +      +I P P THPLLV VNPKSGG+QG+R+L KF Y+LNP+QVFNL   
Sbjct: 378 K--GELVMQ----YKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNG 431

Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
           GP  GL  F+D PD R+L CGGDGTVGWIL+ IDKAN    PPVAVLPLGTGNDLARCLR
Sbjct: 432 GPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLR 491

Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDAS 532
           WGGGYEG +L KILKD+E S +V +DRW +EVIP++  E  D VP+ I+NNYFSIGVDAS
Sbjct: 492 WGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDAS 551

Query: 533 IAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNL 592
           IAHRFH+MREK+PEKFNSRMKNKLWYFEF TSE+  +TCKKL + + +E  G  +DLSN+
Sbjct: 552 IAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNI 611

Query: 593 SLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDK 652
            LEGIA+LNIPSM+GG+NLWG+ ++           +  + K +TDP  LK CV DLSD+
Sbjct: 612 FLEGIAILNIPSMYGGTNLWGENKKNRA-------VIRESRKGVTDPKELKFCVQDLSDQ 664

Query: 653 RLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKIT 712
            LEVVGLEGA+EMGQIYT LK+AGRRLA+C+ +T  T K LPMQ+DGEPWMQ  CTIKIT
Sbjct: 665 LLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKIT 724

Query: 713 HKNQMPMLMGPPPRSTNF 730
           HKNQ PM+MGPP +S+ F
Sbjct: 725 HKNQAPMMMGPPQKSSFF 742


>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
          Length = 1065

 Score =  286 bits (733), Expect = 4e-77
 Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)

Query: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
           +G+H+W        + C L E +  +   K  L   C +CK  VH  C         +  
Sbjct: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233

Query: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
           P      ++S ++  V+ H WV    + G+C +C K  +    +HS  +  + C WC   
Sbjct: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292

Query: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
            H+      L  +   C  G     I+PP+ I        S+ AS   +K +    K S+
Sbjct: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352

Query: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
           + M+  N      ++    P   PLLVFVNPKSGG QG +VL  F + LNPRQVF+L ++
Sbjct: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412

Query: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
           GP+  L L++ VP+ RIL CGGDGTVGWIL  +D+  L   PPV VLPLGTGNDLAR L 
Sbjct: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472

Query: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
           WGGGY  + ++KIL  +E   VV +DRW++ V       P++ E+    +P  + NNYFS
Sbjct: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532

Query: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
           +G DA +   FH  RE  PEKFNSR +NK++Y   A S+ +  + + L + + V   G  
Sbjct: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592

Query: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
           L   +  L  + I  LNIP    G+  WG+     GD +                     
Sbjct: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634

Query: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
                 D  +EV+G       A+++G         G RL +C E+   T K++PMQ+DGE
Sbjct: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682

Query: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
           P    P  I+I+ +NQ  M+     R++
Sbjct: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710


>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
          Length = 929

 Score =  279 bits (714), Expect = 6e-75
 Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)

Query: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
           G+H+W          +    YC   + + S+   K    C  CK  VH  C         
Sbjct: 96  GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 151

Query: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
           +  P    + +++ ++     H WV    + G+C  C K  +    +HS  +  + C WC
Sbjct: 152 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 211

Query: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
               H ++    LQ +   C  G+    ++PP+ I       + L +   +K +   + S
Sbjct: 212 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 271

Query: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
            K   +        +R  P P   PLLVFVNPKSGG QG +++  F + LNPRQVF+L +
Sbjct: 272 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 331

Query: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
            GP+  L +++ V + RIL CGGDGTVGWIL T+D+  L   PPVA+LPLGTGNDLAR L
Sbjct: 332 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 391

Query: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
            WGGGY  + ++KIL  +E   VV +DRW +   P        + E  +D +P  + NNY
Sbjct: 392 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 451

Query: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
           FS+G DA +   FH  RE  PEKFNSR +NK++Y   A S+ +  + K L + + V   G
Sbjct: 452 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 511

Query: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
             L   + +L  + +  LNIP    G+  WG     H                  +P   
Sbjct: 512 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 553

Query: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
                   D  LEV+G       A+++G         G RL +C E+   T+K +P+Q+D
Sbjct: 554 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 601

Query: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
           GEP       I+I  +NQ  M+     RS
Sbjct: 602 GEPCKLAASRIRIALRNQATMVQKAKRRS 630


>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
          Length = 895

 Score =  279 bits (714), Expect = 6e-75
 Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)

Query: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
           G+H+W          +    YC   + + S+   K    C  CK  VH  C         
Sbjct: 62  GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117

Query: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
           +  P    + +++ ++     H WV    + G+C  C K  +    +HS  +  + C WC
Sbjct: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177

Query: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
               H ++    LQ +   C  G+    ++PP+ I       + L +   +K +   + S
Sbjct: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237

Query: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
            K   +        +R  P P   PLLVFVNPKSGG QG +++  F + LNPRQVF+L +
Sbjct: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297

Query: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
            GP+  L +++ V + RIL CGGDGTVGWIL T+D+  L   PPVA+LPLGTGNDLAR L
Sbjct: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357

Query: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
            WGGGY  + ++KIL  +E   VV +DRW +   P        + E  +D +P  + NNY
Sbjct: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417

Query: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
           FS+G DA +   FH  RE  PEKFNSR +NK++Y   A S+ +  + K L + + V   G
Sbjct: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477

Query: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
             L   + +L  + +  LNIP    G+  WG     H                  +P   
Sbjct: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519

Query: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
                   D  LEV+G       A+++G         G RL +C E+   T+K +P+Q+D
Sbjct: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567

Query: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
           GEP       I+I  +NQ  M+     RS
Sbjct: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596


>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
          Length = 1117

 Score =  279 bits (713), Expect = 8e-75
 Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)

Query: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
           C  CK  VH  C         +  P    + +++ ++     H WV    + G+C  C K
Sbjct: 319 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 378

Query: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
             +    +HS  +  + C WC    H ++    LQ +   C  G+    ++PP+ I    
Sbjct: 379 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 438

Query: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
              + L +   +K +   + S K   +        +R  P P   PLLVFVNPKSGG QG
Sbjct: 439 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 498

Query: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
            +++  F + LNPRQVF+L + GP+  L +++ V + RIL CGGDGTVGWIL T+D+  L
Sbjct: 499 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 558

Query: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
              PPVA+LPLGTGNDLAR L WGGGY  + ++KIL  +E   VV +DRW +   P    
Sbjct: 559 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 618

Query: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
               + E  +D +P  + NNYFS+G DA +   FH  RE  PEKFNSR +NK++Y   A 
Sbjct: 619 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 678

Query: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
           S+ +  + K L + + V   G  L   + +L  + +  LNIP    G+  WG     H  
Sbjct: 679 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 737

Query: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
                           +P           D  LEV+G       A+++G         G 
Sbjct: 738 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 768

Query: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
           RL +C E+   T+K +P+Q+DGEP       I+I  +NQ  M+     RS
Sbjct: 769 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 818


>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
          Length = 945

 Score =  279 bits (713), Expect = 8e-75
 Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)

Query: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
           C  CK  VH  C         +  P    + +++ ++     H WV    + G+C  C K
Sbjct: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206

Query: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
             +    +HS  +  + C WC    H ++    LQ +   C  G+    ++PP+ I    
Sbjct: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266

Query: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
              + L +   +K +   + S K   +        +R  P P   PLLVFVNPKSGG QG
Sbjct: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326

Query: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
            +++  F + LNPRQVF+L + GP+  L +++ V + RIL CGGDGTVGWIL T+D+  L
Sbjct: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386

Query: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
              PPVA+LPLGTGNDLAR L WGGGY  + ++KIL  +E   VV +DRW +   P    
Sbjct: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446

Query: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
               + E  +D +P  + NNYFS+G DA +   FH  RE  PEKFNSR +NK++Y   A 
Sbjct: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506

Query: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
           S+ +  + K L + + V   G  L   + +L  + +  LNIP    G+  WG     H  
Sbjct: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565

Query: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
                           +P           D  LEV+G       A+++G         G 
Sbjct: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596

Query: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
           RL +C E+   T+K +P+Q+DGEP       I+I  +NQ  M+     RS
Sbjct: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646


>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
          Length = 567

 Score =  276 bits (706), Expect = 5e-74
 Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)

Query: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
           +H WR    F +P YC +C   I    QG  C+ C   V + C  KA     C+      
Sbjct: 59  KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115

Query: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
             K +    H W+RG       C  C+++      L    C+WC   +HD+C++      
Sbjct: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175

Query: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
           +CD G  ++ I+PPS +     +    RK+ KT             E L         PL
Sbjct: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220

Query: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
           ++  N +SG   G+ +L +F+ +LNP QVF++ K  P   L+L   +P   +R+LVCGGD
Sbjct: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280

Query: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
           GTVGW+L+ +D    K     +P VAVLPLGTGNDL+  L WG GY G+  +A++L+++ 
Sbjct: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340

Query: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
            +  + +DRW V+V  +       P  F + NNYFS+G DA +A  FH  REK P  F+S
Sbjct: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399

Query: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
           R+ NK  Y  + T + +   CK L + + +E+ G+ + L   SLEGI VLNI    GG  
Sbjct: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457

Query: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
           LW              + +G     +   D          D  LEVVG+ G+    QI  
Sbjct: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493

Query: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
           KL N          R + KCS         +PMQ+DGEPW Q PCT+ ITHK    ML
Sbjct: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 8/66 (12%)

Query: 197 EMTLKDDGQ------HMWRPKRFPRPVYCNLCESSIGLGKQ--GLSCNLCKYTVHDQCAM 248
           E+ LK+D +      H W     P   YC +C+   G   +     C  C+ TVHD+C  
Sbjct: 110 EIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169

Query: 249 KALPCE 254
            +L  E
Sbjct: 170 NSLKNE 175


>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
          Length = 942

 Score =  228 bits (580), Expect = 2e-59
 Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)

Query: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
           P++ PLLVFVNPKSGG +G+ +L  F+ +LNP QVF+L   GP  GL LF  VP  R+LV
Sbjct: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643

Query: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
           CGGDGTVGW+L  +++    +    P VA+LPLGTGNDL R LRWG GY G++   +L  
Sbjct: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703

Query: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
           ++ +  V MDRW++ +   +      + +D  P +I+  +NY  IG+DA ++  FH  RE
Sbjct: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763

Query: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
           + P KF SR+ NK  Y      +   S  + L + + +++  + ++L   S+EG+  +NI
Sbjct: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819

Query: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
           PS   G++LWG                       +D    K   P + D  LEVVG+ G 
Sbjct: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855

Query: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
           + MGQ+   L++ G R+A+ S       K  P+Q+DGEPW+Q P
Sbjct: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)

Query: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
           H + P+   +  +C +C     L    L C +C+  +H  C   A       +    +D 
Sbjct: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179

Query: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
               H W  G   SG RC+ C+K       L G+ C WC ++ H  C  A+  EC  G L
Sbjct: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239

Query: 325 RDHILPPSSI 334
           R  +LPP+ +
Sbjct: 240 RSLVLPPACV 249



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)

Query: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
           H +R     +P +C+LC   I  G  G  C++C +  H++C     +PC  ++ A S   
Sbjct: 61  HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117

Query: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
           + V      RG  +   C  C+K +        LHC  C L +H DC+     +C
Sbjct: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168


>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
           sapiens]
          Length = 1170

 Score =  206 bits (523), Expect = 8e-53
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177

Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237

Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275

Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335

Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395

Query: 494 VVHMDRWSV 502
              +DRWSV
Sbjct: 396 TKMLDRWSV 404



 Score =  126 bits (317), Expect = 6e-29
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778

Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818

Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872

Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
           DGE W+Q P  I+I HKN+   L
Sbjct: 873 DGEAWVQPPGYIRIVHKNRAQTL 895


>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
           sapiens]
          Length = 1214

 Score =  206 bits (523), Expect = 8e-53
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 162 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 221

Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 222 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 281

Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 282 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 319

Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 320 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 379

Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 380 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 439

Query: 494 VVHMDRWSV 502
              +DRWSV
Sbjct: 440 TKMLDRWSV 448



 Score =  126 bits (317), Expect = 6e-29
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822

Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 823 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 862

Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 863 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 916

Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
           DGE W+Q P  I+I HKN+   L
Sbjct: 917 DGEAWVQPPGYIRIVHKNRAQTL 939


>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
          Length = 1164

 Score =  205 bits (521), Expect = 1e-52
 Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)

Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
           G H W      RP +CN+C  S+ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233

Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
            KDI     GV   H W+ G    S +C  C K       L    C+WC   +H  C   
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293

Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
               C  G  +  I+PP ++            NS  S    D    +T            
Sbjct: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330

Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+   + RILVCGG
Sbjct: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390

Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
           DG+VGW+L  IDK NL     + VLPLGTGNDLAR L WGG Y+    L +IL+ LE + 
Sbjct: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450

Query: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
              +DRWS+     +   K+  +P
Sbjct: 451 TKMLDRWSIMTYELKLPPKASLLP 474



 Score =  127 bits (320), Expect = 3e-29
 Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
           ++NNYF IG+DA I+  F+  RE++PEK  SR KN +WY    T E +  + K LE+ + 
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829

Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
           +E  G+ + L   SL+GIAVLNIPS  GG+N WG T+    DI+                
Sbjct: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869

Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
                  P   DK LEVV +  +++M  +   +K    R+A+C   +IT    + +P+Q+
Sbjct: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923

Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
           DGE W+Q P  IKI HKN+  ML
Sbjct: 924 DGEAWVQPPGIIKIVHKNRAQML 946


>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
          Length = 1220

 Score =  205 bits (521), Expect = 1e-52
 Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)

Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
           G H W      RP +CN+C  S+ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233

Query: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
            KDI     GV   H W+ G    S +C  C K       L    C+WC   +H  C   
Sbjct: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293

Query: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
               C  G  +  I+PP ++            NS  S    D    +T            
Sbjct: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330

Query: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+   + RILVCGG
Sbjct: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390

Query: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
           DG+VGW+L  IDK NL     + VLPLGTGNDLAR L WGG Y+    L +IL+ LE + 
Sbjct: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450

Query: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
              +DRWS+     +   K+  +P
Sbjct: 451 TKMLDRWSIMTYELKLPPKASLLP 474



 Score =  127 bits (320), Expect = 3e-29
 Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
           ++NNYF IG+DA I+  F+  RE++PEK  SR KN +WY    T E +  + K LE+ + 
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829

Query: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
           +E  G+ + L   SL+GIAVLNIPS  GG+N WG T+    DI+                
Sbjct: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869

Query: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
                  P   DK LEVV +  +++M  +   +K    R+A+C   +IT    + +P+Q+
Sbjct: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923

Query: 698 DGEPWMQTPCTIKITHKNQMPML 720
           DGE W+Q P  IKI HKN+  ML
Sbjct: 924 DGEAWVQPPGIIKIVHKNRAQML 946


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score =  191 bits (486), Expect = 2e-48
 Identities = 119/317 (37%), Positives = 161/317 (50%), Gaps = 26/317 (8%)

Query: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
           G H W      R  +CN+C  SI  L +  + C +CK   H  CA++A   C+ +T + +
Sbjct: 326 GMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSIT 385

Query: 262 RK-----DIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAV 315
                  D     H WV G    S +C  C +    Y  L    C+WC+  +HDDC +  
Sbjct: 386 DDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRF 445

Query: 316 GHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTH 375
             EC     R  ++PP+++         D K       + D  NL  S A          
Sbjct: 446 SKECCFRSHRSSVIPPTAL--------SDPKGDGQLVVSSDFWNLDWSSACSC------- 490

Query: 376 PLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGD 435
           PLL+F+N KSG  QG   L KF+  LNP QVF+LLK GPE GL +FK+    RILVCGGD
Sbjct: 491 PLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGD 550

Query: 436 GTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGY-EGQNLAKILKDLEMSKV 494
           G+V W+L  ID   L     +AV+PLGTGNDLAR L WG  + + ++   IL  +E + V
Sbjct: 551 GSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASV 610

Query: 495 VHMDRWSVEV--IPQQT 509
             +DRWSV +   P+QT
Sbjct: 611 RILDRWSVMIRETPRQT 627



 Score =  121 bits (304), Expect = 2e-27
 Identities = 75/204 (36%), Positives = 113/204 (55%), Gaps = 30/204 (14%)

Query: 520  IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
            ++NNYF IG+DA I+  F+  R+++P ++NSR+KNK+WY    T E +  + +KLEE + 
Sbjct: 857  VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916

Query: 580  VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
            +E  G+ + L NL  +GI VLNI S  GG N WG                 AT +     
Sbjct: 917  LECDGETISLPNL--QGIVVLNITSYAGGINFWGSNT--------------ATTEYEA-- 958

Query: 640  DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGR-RLAKCSE--ITFHTTKTLPMQ 696
                   P + D +LEVV + G+++M    +++ N    R+A+C E  IT    + +P+Q
Sbjct: 959  -------PAIDDGKLEVVAIFGSVQMAM--SRIINLHHHRIAQCHEVMITIDGEEGIPVQ 1009

Query: 697  IDGEPWMQTPCTIKITHKNQMPML 720
            +DGE W+Q P  IKI +KN   ML
Sbjct: 1010 VDGEAWIQRPGLIKIRYKNAAQML 1033


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 26/53 (49%), Positives = 31/53 (58%), Gaps = 1/53 (1%)

Query: 204 GQHMWRPKRFPRPVYCNLCES-SIGLGKQGLSCNLCKYTVHDQCAMKALPCEV 255
           G H  RP+ FP P  C  C S  +GLG+QGL C+ C Y  H  CA +A PC V
Sbjct: 877 GSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPV 929


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 52/214 (24%), Positives = 86/214 (40%), Gaps = 28/214 (13%)

Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
           H +  + F +P +C+ C   I G+GKQGL C +C + VH +C       C  +       
Sbjct: 36  HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCG 322
           D   +    +        CD C   +  + H   G+ C  C + +H  C+++V   C   
Sbjct: 96  DPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQ--GMKCSCCEMNVHRRCVRSVPSLCGV- 152

Query: 323 LLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPV-PN--THP--- 376
              DH                 R   +    T D+++++  EA  + P+ PN  + P   
Sbjct: 153 ---DH------------TERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVK 197

Query: 377 LLVFVNPKSGGKQGQR-VLWKFQYILNPRQVFNL 409
           L +  +P++  KQ  R V      + N   VFNL
Sbjct: 198 LKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNL 231


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 10/116 (8%)

Query: 213 FPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK-------- 263
           F +P +C++C+  + GL KQG  C  C   +H +C  K +     T A SR         
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
           +I +     V        CD C   +       GL C  C + +H  C + V + C
Sbjct: 226 NIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKCREKVANLC 280


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 10/116 (8%)

Query: 213 FPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK-------- 263
           F +P +C++C+  + GL KQG  C  C   +H +C  K +     T A SR         
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
           +I +     V        CD C   +       GL C  C + +H  C + V + C
Sbjct: 226 NIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKCREKVANLC 280


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 45/183 (24%), Positives = 69/183 (37%), Gaps = 20/183 (10%)

Query: 206 HMWRPKRFPRPVYCNLCESSIG--LGKQGLSCNLCKYTVHDQC---AMKALPCE------ 254
           H +      +P YC+ C   I    GKQG  C +C   VH +C    + A  C+      
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 231

Query: 255 VSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
            S  A+ R  I +     +        CD C   +       GL C  C + +H  C   
Sbjct: 232 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGI-MRQGLQCKICKMNVHIRCQAN 290

Query: 315 VGHECDCG------LLRDHILPPSSIYPS--VLASGPDRKNSKTSQKTMDDLNLSTSEAL 366
           V   C          L    L P +I P+  +++    R+  K S K  + + +++S  L
Sbjct: 291 VAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRL 350

Query: 367 RID 369
            ID
Sbjct: 351 GID 353


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/117 (24%), Positives = 47/117 (40%), Gaps = 5/117 (4%)

Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
           H +  + F +P +C+ C   I G GKQG  C +C + VH +C       C  +    +  
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
           D   +    +        CD C   +  + H   G+ C  C + +H  C+  V   C
Sbjct: 97  DPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQ--GMKCDTCMMNVHKRCVMNVPSLC 151



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)

Query: 205 QHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK 263
           +H ++   +  P +C+ C S + GL  QG+ C+ C   VH +C M       + + + R 
Sbjct: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG 160

Query: 264 DIGVQSHV 271
            I +Q+H+
Sbjct: 161 RIYIQAHI 168


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/117 (24%), Positives = 47/117 (40%), Gaps = 5/117 (4%)

Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
           H +  + F +P +C+ C   I G GKQG  C +C + VH +C       C  +    +  
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
           D   +    +        CD C   +  + H   G+ C  C + +H  C+  V   C
Sbjct: 97  DPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQ--GMKCDTCMMNVHKRCVMNVPSLC 151



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)

Query: 205 QHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRK 263
           +H ++   +  P +C+ C S + GL  QG+ C+ C   VH +C M       + + + R 
Sbjct: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG 160

Query: 264 DIGVQSHV 271
            I +Q+H+
Sbjct: 161 RIYIQAHI 168


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 31/123 (25%), Positives = 49/123 (39%), Gaps = 10/123 (8%)

Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMK--------ALPCEVS 256
           H +    FP+P +C++C   + GL KQG  C  C   +H +C  K        A+    +
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRET 219

Query: 257 TYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVG 316
            + K R  I +     V        C+ C   +    +  GL C  C + +H  C   V 
Sbjct: 220 MFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGL-ARQGLKCDACGMNVHHRCQTKVA 278

Query: 317 HEC 319
           + C
Sbjct: 279 NLC 281



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 1/50 (2%)

Query: 201 KDDGQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMK 249
           K D  H ++   +  P +C  C + + GL +QGL C+ C   VH +C  K
Sbjct: 227 KIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK 276


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 51/205 (24%), Positives = 79/205 (38%), Gaps = 25/205 (12%)

Query: 206 HMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQC-AMKALPCEVSTYAKSRK 263
           H +  + F +P +C+ C   I G GKQG  C +C + VH +C       C  +       
Sbjct: 37  HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTD 96

Query: 264 DIGVQSHVWVRGGCESGRCDRCQKKI-RIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCG 322
           D   +    +        CD C   +  + H   G+ C  C + +H  C+  V   C   
Sbjct: 97  DPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQ--GMKCDTCDMNVHKQCVINVPSLCG-- 152

Query: 323 LLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHP---LLV 379
              DH      IY  + A   D K   T     D  NL     + +DP   + P   L +
Sbjct: 153 --MDHTEKRGRIY--LKAEVADEKLHVT---VRDAKNL-----IPMDPNGLSDPYVKLKL 200

Query: 380 FVNPKSGGKQGQRVLWKFQYILNPR 404
             +PK+  KQ  + +   +  LNP+
Sbjct: 201 IPDPKNESKQKTKTI---RSTLNPQ 222


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,885,059
Number of Sequences: 37866
Number of extensions: 1394310
Number of successful extensions: 3662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 3314
Number of HSP's gapped (non-prelim): 280
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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