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Search of human proteins with 41281453
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281453 serine/threonine kinase 2 [Homo sapiens]
(1235 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 2414 0.0
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 607 e-173
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 260 6e-69
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 259 8e-69
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 255 2e-67
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 253 8e-67
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 248 2e-65
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 246 1e-64
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 244 3e-64
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 244 3e-64
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 244 5e-64
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 244 5e-64
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 243 8e-64
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 242 1e-63
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 242 1e-63
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 242 1e-63
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 242 1e-63
gi|145275208 myosin IIIA [Homo sapiens] 241 2e-63
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 240 7e-63
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 239 1e-62
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 238 3e-62
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 238 3e-62
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 238 3e-62
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 237 6e-62
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 237 6e-62
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 236 1e-61
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 233 8e-61
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 233 1e-60
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 233 1e-60
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 230 5e-60
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 2414 bits (6255), Expect = 0.0
Identities = 1235/1235 (100%), Positives = 1235/1235 (100%)
Query: 1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA 60
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
Sbjct: 1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA 60
Query: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120
AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
Sbjct: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120
Query: 121 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 180
LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
Sbjct: 121 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 180
Query: 181 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 240
TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
Sbjct: 181 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 240
Query: 241 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 300
MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
Sbjct: 241 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 300
Query: 301 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL 360
RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
Sbjct: 301 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL 360
Query: 361 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK 420
ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
Sbjct: 361 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK 420
Query: 421 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM 480
ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
Sbjct: 421 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM 480
Query: 481 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD 540
FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
Sbjct: 481 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD 540
Query: 541 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV 600
VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
Sbjct: 541 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV 600
Query: 601 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT 660
PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
Sbjct: 601 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT 660
Query: 661 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 720
DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
Sbjct: 661 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 720
Query: 721 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI 780
ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
Sbjct: 721 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI 780
Query: 781 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE 840
SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
Sbjct: 781 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE 840
Query: 841 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL 900
EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
Sbjct: 841 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL 900
Query: 901 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE 960
RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE
Sbjct: 901 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE 960
Query: 961 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH 1020
QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH
Sbjct: 961 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH 1020
Query: 1021 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK 1080
QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK
Sbjct: 1021 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK 1080
Query: 1081 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA 1140
TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA
Sbjct: 1081 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA 1140
Query: 1141 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 1200
NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
Sbjct: 1141 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 1200
Query: 1201 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS 1235
EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
Sbjct: 1201 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS 1235
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 607 bits (1566), Expect = e-173
Identities = 320/650 (49%), Positives = 444/650 (68%), Gaps = 28/650 (4%)
Query: 608 MNEIEEGKNK---EQAINSSENIMDINEE------PGTTEGEEITESSSTE---EMEVRS 655
M EIE+G+++ E A++++ + + + P + + ES ST S
Sbjct: 315 MEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDS 374
Query: 656 VVADTDQKALGSEVQDASKVTTQIDKE---------KKEIPVSIKKEPEVTVVSQPTEPQ 706
V Q + +Q S E +K PVS+ +V Q E
Sbjct: 375 VNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQG 434
Query: 707 PVLIPSININSDSGENKEEIGSLSK-------TETILPPESENPKENDNDSGTGSTADTS 759
L P+ N + + +++ +L ++ PP P + DS S +
Sbjct: 435 GDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSE 494
Query: 760 SIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSK 819
S+D ++S+ LS K+ GS+S+++ + KKTLK+TRKF+VDGVEVS+TTSKI+++ + K
Sbjct: 495 SMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKK 554
Query: 820 TEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIE 879
EE+RFLRRQELRELR LQKEE R Q QL++K + Q EQ+ +RFEQE+ +KK+ +D E+E
Sbjct: 555 DEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELE 614
Query: 880 NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKE 939
NLE+QQKQ +E++EQ+H R R+EA+RI+ EQ+++ ++FQ LK KKEV NEVEK P++
Sbjct: 615 NLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQ 674
Query: 940 LRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQ 999
RKE MK++ EE Q + +++FV KQ+++L+ ++K++ + E+ + ERECL KQ+
Sbjct: 675 QRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQE 734
Query: 1000 LMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEE 1059
L+R REAA+WE+EE LQE+HQL+KQQLKDQYF+QRH+LL++HEKE EQMQRYNQR+IE+
Sbjct: 735 LLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQ 794
Query: 1060 LKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNE 1119
LK RQ QE+ARLPKIQRSE KTRMAM+KKSL IN + + R+KIKQF+ QEEKRQK+E
Sbjct: 795 LKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSE 854
Query: 1120 RMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWR 1179
R+ Q QKHENQMRD+ QCE+N+ EL QLQNEKCHLLVEHETQKLK LDE H+Q LKEWR
Sbjct: 855 RLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWR 914
Query: 1180 EKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPS 1229
+KLRPRKK LEE+ +K +EQE+FFK++ E+EC NPST S+ +KF+P S
Sbjct: 915 DKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSS 964
Score = 510 bits (1313), Expect = e-144
Identities = 253/381 (66%), Positives = 312/381 (81%), Gaps = 9/381 (2%)
Query: 1 MSFFNFRKIFKLGSEKKKK--QYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSV 58
M+F NFR+I +L + +K+K +YEHV+RDL+P + WEI+GELGDGAFGKVYKA+NKET
Sbjct: 1 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA 60
Query: 59 LAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDA 118
LAAAKVI+TKSEEELEDY+VEI+ILA+CDHP IVKLL A+Y++ LWI+IEFC GGAVDA
Sbjct: 61 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA 120
Query: 119 VMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA 178
+MLEL+R LTE QIQVVC+Q L+ALN+LH +IIHRDLKAGN+L TL+GDI+LADFGVSA
Sbjct: 121 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA 180
Query: 179 KNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL 238
KN +T+Q+RDSFIGTPYWMAPEVVMCET KD PYDYKAD+WSLGITLIEMA+IEPPHHEL
Sbjct: 181 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL 240
Query: 239 NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDSN 297
NPMRVLLKIAKS+PPTL PS+WS F+DFLK L+KN + R + +QLL+HPFV ++ SN
Sbjct: 241 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN 300
Query: 298 KPIRELIAEAKAEVTEEVEDGKEEDEEEE-TENSLPIPASKRASSDLSIASSEEDKLSQN 356
K +REL+AEAKAEV EE+EDG++E EEE+ + + + + SS++S S DK +
Sbjct: 301 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLE- 359
Query: 357 ACILESVSEKTERSNSEDKLN 377
ES S S S+D +N
Sbjct: 360 ----ESPSTPLAPSQSQDSVN 376
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 260 bits (664), Expect = 6e-69
Identities = 144/397 (36%), Positives = 234/397 (58%), Gaps = 27/397 (6%)
Query: 7 RKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID 66
R++ KL + KQ PE+ ++++ +LG+G++G VYKA +KET + A K +
Sbjct: 12 RQLKKLDEDSLTKQ---------PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 62
Query: 67 TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP 126
+S+ L++ + EI I+ CD P++VK +++ +LWI++E+C G+V ++ +
Sbjct: 63 VESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
Query: 127 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 186
LTE +I + + TL L YLH + IHRD+KAGNIL +G KLADFGV+ + T T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 187 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 246
R++ IGTP+WMAPEV+ ++ Y+ AD+WSLGIT IEMAE +PP+ +++PMR +
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 247 IAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDSNKPIRELIA 305
I + PPT +P WS NF DF+K+CL K+ + R T +QLLQHPFV + +R+LI
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 306 EA--------KAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNA 357
EA +++ E +D +E EE+E ++ + A + +AS+ D +
Sbjct: 296 EAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMI 355
Query: 358 CILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEK 392
+++ + T N+ED+ + + T +P K
Sbjct: 356 EHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAK 392
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 259 bits (663), Expect = 8e-69
Identities = 150/384 (39%), Positives = 229/384 (59%), Gaps = 37/384 (9%)
Query: 8 KIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT 67
K+ KL + KQ PE+ ++++ +LG+G++G V+KA +KE+ + A K +
Sbjct: 10 KLKKLSEDSLTKQ---------PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
Query: 68 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127
E +L++ + EI I+ CD P +VK +++ +LWI++E+C G+V ++ + L
Sbjct: 61 --ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
Query: 128 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRR 187
E +I + K TL L YLH + IHRD+KAGNIL +G KLADFGV+ + T T+ +R
Sbjct: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
Query: 188 DSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKI 247
++ IGTP+WMAPEV+ ++ Y+ AD+WSLGIT IEMAE +PP+ +++PMR + I
Sbjct: 179 NTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI 233
Query: 248 AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI---RELI 304
+ PPT +P WS +F DF+KKCL KN + R T +QLLQHPF + + KP+ R+LI
Sbjct: 234 PTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF--IKNAKPVSILRDLI 291
Query: 305 AEA---KAEVTEEVEDGKEEDEEEETEN----------SLPIPASKRASSDLSIASSEED 351
EA KA+ EE + EE+EE E+ S+ + RA+S +S +
Sbjct: 292 TEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMS--EGAQT 349
Query: 352 KLSQNACILESVSEKTERSNSEDK 375
+ N+ +LES T NSED+
Sbjct: 350 MIEHNSTMLES-DLGTMVINSEDE 372
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 255 bits (652), Expect = 2e-67
Identities = 218/827 (26%), Positives = 366/827 (44%), Gaps = 90/827 (10%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
RE+ + ++ ++ +E + + + + + +E++ EK+ ++
Sbjct: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
Query: 484 KLIKSEEIKDTILQTVD--LVSQETGEKEANIQAVDSEVGLTKEDTQEKLG------EDD 535
K S K + + + + G Q+V + QE L E
Sbjct: 493 KEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP 552
Query: 536 KTQKDVISNTSDVIGTCEAAD--------------VAQKVDEDSAEDTQSNDGKEVVEVG 581
+ D S + E D V Q+ S + N +G
Sbjct: 553 RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 612
Query: 582 QKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEG-E 640
+L ++P+ + PI E + G + + SS+ +PG+ G
Sbjct: 613 PRLGSQPIRASNPDLRRTEPILE-SPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 671
Query: 641 EITESSSTEEMEVRSVVADTDQKALGSEVQDASKVT-----TQIDKEKKEIPVSIKKEP- 694
E T + + E V+ K E +D ++ + T + KE +E+ + P
Sbjct: 672 ERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPM 731
Query: 695 -EVTVVSQPTEPQPVLIPSININSDSGENKEEIG---------SLSKTETILPPESENPK 744
+VT S +E S+S E +EE G ++S ++P +
Sbjct: 732 KKVTDYSSSSE-----------ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 780
Query: 745 ENDNDSGTGSTA-DTSSIDLNLSISSFLSKTKDSGSISLQETRRQKK 790
E N G+ +TS D SF G++ ++ET +KK
Sbjct: 781 EQYNVGMVGTHGLETSHAD------SFSGSISREGTLMIRETSGEKK 821
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/191 (26%), Positives = 93/191 (48%), Gaps = 19/191 (9%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQ- 894
++EE+ + +S L E RR ++ +K+R + LE+QQ++ E Q
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQL 387
Query: 895 --EHTNRL---RDEAKRIKGEQ--EKELSKFQNMLKNR--KKEVINEVEKAPKELRKELM 945
E R+ +++ +R++ +Q EKEL K Q + R ++++ E E+ E +E
Sbjct: 388 LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
+++ EE Q++ Q Q KQ+++ SL Q Q+ E +E++ L + ++ M E
Sbjct: 448 RKQLEEQRQAERLQRQ---LKQERDYLVSL----QHQRQEQRPVEKKPLYHYKEGMSPSE 500
Query: 1006 AAIWELEERHL 1016
W E HL
Sbjct: 501 KPAWAKEIPHL 511
Score = 47.8 bits (112), Expect = 7e-05
Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 20/232 (8%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR 1082
+ + HE+E ++ Q QR E L+ + QER L +Q + R
Sbjct: 431 MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 482
Score = 45.8 bits (107), Expect = 3e-04
Identities = 37/145 (25%), Positives = 73/145 (50%), Gaps = 16/145 (11%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931
E E + E+Q ++ ER EH E KR + E++++ + Q LK + +++
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 932 EVEKAPKELRKELMKRRKEELAQSQ 956
+ + + K+ + KE ++ S+
Sbjct: 476 HQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/177 (24%), Positives = 90/177 (50%), Gaps = 34/177 (19%)
Query: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072
+ L+ QL K++ R Q L++ ++E E+ +R Q+ IEE Q ++R RL
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
Query: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
+ QR E + R Q+R++ + + +E+ R++ ER + +HE + +
Sbjct: 407 EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
Query: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKK 1187
QL+ + L QL+ E+ +L+ ++H+ Q+ + +++ + L ++E + P +K
Sbjct: 448 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK 501
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/292 (21%), Positives = 128/292 (43%), Gaps = 33/292 (11%)
Query: 787 RQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQ 846
+ KK KK + FI S +V + + + ++ +R+ Q E++ +
Sbjct: 254 KSKKWSKKFQSFI---------ESCLVKNHSQRPATEQLMKHPFIRD----QPNERQVRI 300
Query: 847 QLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKR 906
QL + + +++ + E E + ++E EN + + +I L E T R RD +
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEE-EN-DSGEPSSILNLPGESTLR-RDFLRL 357
Query: 907 IKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQK 966
+E+ + + L+ +++E NE K ++L E KR +E+ Q + +EQ Q+
Sbjct: 358 QLANKERSEALRRQQLEQQQRE--NEEHK--RQLLAERQKRIEEQKEQRRRLEEQ---QR 410
Query: 967 QQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIW---ELEERHLQEKHQLL 1023
+++EL +QQ+ E E + +++ RA + +LEE+ E+ Q
Sbjct: 411 REKELR-------KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Query: 1024 KQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
+Q +D +HQ ++ E + + Y + + K +E L ++
Sbjct: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 515
Score = 35.4 bits (80), Expect = 0.34
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 26/191 (13%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDE----EHSQELKEWREKLRPRKKTL 1189
+ + E R +L+ ++ H ++++ +E EH QE K RK+
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK--------RKQLE 452
Query: 1190 EEEFARKLQEQ 1200
E+ A +LQ Q
Sbjct: 453 EQRQAERLQRQ 463
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 862 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 921
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 922 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 981
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 982 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1041
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1042 GWITVGDLEGCIHYKVVKYERIKFLVI 1068
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 253 bits (646), Expect = 8e-67
Identities = 215/824 (26%), Positives = 364/824 (44%), Gaps = 76/824 (9%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
RE+ + ++ ++ +E + + + + + +E++ EK+ ++
Sbjct: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
Query: 484 KLIKSEEIKDTILQTVD--LVSQETGEKEANIQAVDSEVGLTKEDTQEKLG------EDD 535
K S K + + + + G Q+V + QE L E
Sbjct: 493 KEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP 552
Query: 536 KTQKDVISNTSDVIGTCEAAD--------------VAQKVDEDSAEDTQSNDGKEVVEVG 581
+ D S + E D V Q+ S + N +G
Sbjct: 553 RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 612
Query: 582 QKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEG-E 640
+L ++P+ + PI E + G + + SS+ +PG+ G
Sbjct: 613 PRLGSQPIRASNPDLRRTEPILE-SPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 671
Query: 641 EITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEK--KEIPVSIKKEPEVTV 698
E T + + E V+ K E +D ++ + +K E ++ KE
Sbjct: 672 ERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELR 731
Query: 699 VSQPTEPQPVL--IPSININSDSGENKEEIG---------SLSKTETILPPESENPKEND 747
+ + P + S + S+S E +EE G ++S ++P + E
Sbjct: 732 IEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQY 791
Query: 748 NDSGTGSTA-DTSSIDLNLSISSFLSKTKDSGSISLQETRRQKK 790
N G+ +TS D SF G++ ++ET +KK
Sbjct: 792 NVGMVGTHGLETSHAD------SFSGSISREGTLMIRETSGEKK 829
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/191 (26%), Positives = 93/191 (48%), Gaps = 19/191 (9%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQ- 894
++EE+ + +S L E RR ++ +K+R + LE+QQ++ E Q
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQL 387
Query: 895 --EHTNRL---RDEAKRIKGEQ--EKELSKFQNMLKNR--KKEVINEVEKAPKELRKELM 945
E R+ +++ +R++ +Q EKEL K Q + R ++++ E E+ E +E
Sbjct: 388 LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
+++ EE Q++ Q Q KQ+++ SL Q Q+ E +E++ L + ++ M E
Sbjct: 448 RKQLEEQRQAERLQRQ---LKQERDYLVSL----QHQRQEQRPVEKKPLYHYKEGMSPSE 500
Query: 1006 AAIWELEERHL 1016
W E HL
Sbjct: 501 KPAWAKEIPHL 511
Score = 47.8 bits (112), Expect = 7e-05
Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 20/232 (8%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR 1082
+ + HE+E ++ Q QR E L+ + QER L +Q + R
Sbjct: 431 MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 482
Score = 45.8 bits (107), Expect = 3e-04
Identities = 37/145 (25%), Positives = 73/145 (50%), Gaps = 16/145 (11%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931
E E + E+Q ++ ER EH E KR + E++++ + Q LK + +++
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 932 EVEKAPKELRKELMKRRKEELAQSQ 956
+ + + K+ + KE ++ S+
Sbjct: 476 HQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/177 (24%), Positives = 90/177 (50%), Gaps = 34/177 (19%)
Query: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072
+ L+ QL K++ R Q L++ ++E E+ +R Q+ IEE Q ++R RL
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
Query: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
+ QR E + R Q+R++ + + +E+ R++ ER + +HE + +
Sbjct: 407 EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
Query: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKK 1187
QL+ + L QL+ E+ +L+ ++H+ Q+ + +++ + L ++E + P +K
Sbjct: 448 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK 501
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/292 (21%), Positives = 128/292 (43%), Gaps = 33/292 (11%)
Query: 787 RQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQ 846
+ KK KK + FI S +V + + + ++ +R+ Q E++ +
Sbjct: 254 KSKKWSKKFQSFI---------ESCLVKNHSQRPATEQLMKHPFIRD----QPNERQVRI 300
Query: 847 QLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKR 906
QL + + +++ + E E + ++E EN + + +I L E T R RD +
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEE-EN-DSGEPSSILNLPGESTLR-RDFLRL 357
Query: 907 IKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQK 966
+E+ + + L+ +++E NE K ++L E KR +E+ Q + +EQ Q+
Sbjct: 358 QLANKERSEALRRQQLEQQQRE--NEEHK--RQLLAERQKRIEEQKEQRRRLEEQ---QR 410
Query: 967 QQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIW---ELEERHLQEKHQLL 1023
+++EL +QQ+ E E + +++ RA + +LEE+ E+ Q
Sbjct: 411 REKELR-------KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463
Query: 1024 KQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
+Q +D +HQ ++ E + + Y + + K +E L ++
Sbjct: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 515
Score = 35.4 bits (80), Expect = 0.34
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 26/191 (13%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDE----EHSQELKEWREKLRPRKKTL 1189
+ + E R +L+ ++ H ++++ +E EH QE K RK+
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK--------RKQLE 452
Query: 1190 EEEFARKLQEQ 1200
E+ A +LQ Q
Sbjct: 453 EQRQAERLQRQ 463
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 870 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 929
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 930 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 989
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 990 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1049
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1050 GWITVGDLEGCIHYKVVKYERIKFLVI 1076
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 248 bits (634), Expect = 2e-65
Identities = 226/856 (26%), Positives = 374/856 (43%), Gaps = 119/856 (13%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 R-EKRPKLENLPD------TEDQETVDINSVSEGKENNIMITLE----------TNIEHN 466
R E+R + E+ + E+Q ++I E +++ + ++
Sbjct: 433 REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQ 492
Query: 467 LKSE------------EEKDQEKQQMFENKLIKSEEIKDTILQTVD--LVSQETGEKEAN 512
LK E E++ EK+ ++ K S K + + + + G
Sbjct: 493 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTA 552
Query: 513 IQAVDSEVGLTKEDTQEKLG------EDDKTQKDVISNTSDVIGTCEAAD---------- 556
Q+V + QE L E + D S + E D
Sbjct: 553 SQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED 612
Query: 557 ----VAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIE 612
V Q+ S + N +G +L ++P+ + PI E +
Sbjct: 613 IPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILE-SPLQRTS 671
Query: 613 EGKNKEQAINSSENIMDINEEPGTTEG-EEITESSSTEEMEVRSVVADTDQKALGSEVQD 671
G + + SS+ +PG+ G E T + + E V+ K E +D
Sbjct: 672 SGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRD 731
Query: 672 ASKVT-----TQIDKEKKEIPVSIKKEP--EVTVVSQPTEPQPVLIPSININSDSGENKE 724
++ + T + KE +E+ + P +VT S +E S+S E +E
Sbjct: 732 ITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSE-----------ESESSEEEE 780
Query: 725 EIG---------SLSKTETILPPESENPKENDNDSGTGSTA-DTSSIDLNLSISSFLSKT 774
E G ++S ++P + E N G+ +TS D SF
Sbjct: 781 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHAD------SFSGSI 834
Query: 775 KDSGSISLQETRRQKK 790
G++ ++ET +KK
Sbjct: 835 SREGTLMIRETSGEKK 850
Score = 58.9 bits (141), Expect = 3e-08
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 32/203 (15%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKKEVINEV 933
E E +R E R +E +R + EQE ++L + Q L+ ++++++E
Sbjct: 420 ERE----------QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 934 EKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIEREC 993
+ RK+L ++R+ E Q Q QE++++ +Q Q+ E +E++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKP 517
Query: 994 LNNKQQLMRAREAAIWELEERHL 1016
L + ++ M E W E HL
Sbjct: 518 LYHYKEGMSPSEKPAWAKEIPHL 540
Score = 58.2 bits (139), Expect = 5e-08
Identities = 52/240 (21%), Positives = 117/240 (48%), Gaps = 25/240 (10%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQE 895
++EE+ + +S L E RR ++ +K+R E L +QQ + +R +E
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERS-----EALRRQQLEQQQRENEE 382
Query: 896 HTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955
H +L E ++ EQ+++ + + + R+KE+ + E+ + +E M RR+EE ++
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQRRHYEEQM-RREEERRRA 440
Query: 956 QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015
+H EQE++++Q +++++ +L ++++ L+ + L+ + +LEE+
Sbjct: 441 EH--EQEYIRRQ-----------LEEEQRQLEILQQQLLHEQALLLEYKRK---QLEEQR 484
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
E+ Q +Q +D +HQ ++ E + + Y + + K +E L ++
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 544
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 120/262 (45%), Gaps = 30/262 (11%)
Query: 701 QPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSS 760
QP E Q I + K++ G +TE E +E +NDSG + SS
Sbjct: 292 QPNERQV----RIQLKDHIDRTKKKRGEKDETEYEYSGSEE--EEEENDSG-----EPSS 340
Query: 761 IDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKT 820
I LNL S L + + LQ +++ + ++ E +++ + +
Sbjct: 341 I-LNLPGESTLRRD----FLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRI 395
Query: 821 EELRFLRR----QELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
EE + RR Q+ RE + L+K+++R +Q+ + + Q +RE+ RR E E +RQ ++
Sbjct: 396 EEQKEQRRRLEEQQRRE-KELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN--EVE 934
E LE Q+Q + H L E KR + E++++ + Q LK + +++
Sbjct: 454 EQRQLEILQQQLL------HEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 507
Query: 935 KAPKELRKELMKRRKEELAQSQ 956
+ + + K+ + KE ++ S+
Sbjct: 508 QEQRPVEKKPLYHYKEGMSPSE 529
Score = 45.4 bits (106), Expect = 3e-04
Identities = 62/278 (22%), Positives = 124/278 (44%), Gaps = 28/278 (10%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQ-----YF 1032
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1033 MQRHQLLKRHEKETEQMQRY---NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKS 1089
M+R + +R E E E ++R QR +E L+ + E+A L + +R + + + +
Sbjct: 431 MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQ 490
Query: 1090 LRINSTATPDQDRDKIKQFAAQ-EEKRQKNERMAQHQK 1126
++ Q+RD + Q +E+R ++ H K
Sbjct: 491 RQLK------QERDYLVSLQHQRQEQRPVEKKPLYHYK 522
Score = 38.5 bits (88), Expect = 0.040
Identities = 68/319 (21%), Positives = 142/319 (44%), Gaps = 67/319 (21%)
Query: 901 RDEAKRIKGEQEKELSKFQN-----MLKNRKKEVINE-------VEKAPKE------LRK 942
R+ A R+K + K KFQ+ ++KN + E + P E L+
Sbjct: 247 RNPAPRLKSK--KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKD 304
Query: 943 ELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLN----NKQ 998
+ + +K+ + + E +++++E D I E + + R+ L NK+
Sbjct: 305 HIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE-STLRRDFLRLQLANKE 363
Query: 999 QLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYN--QRL 1056
+ R + + + + + K QLL ++ K R E++ EQ +R QR
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------------RIEEQKEQRRRLEEQQRR 411
Query: 1057 IEELKNRQTQERARLPKIQ-RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKR 1115
+EL+ +Q +E+ R + Q R E + R A + +++ I++ EE++
Sbjct: 412 EKELRKQQEREQRRHYEEQMRREEERRRA--------------EHEQEYIRR--QLEEEQ 455
Query: 1116 QKNERMAQHQKHENQM------RDLQLQCEANVRELHQLQNEKCHLL-VEHETQKLKELD 1168
++ E + Q HE + + L+ Q +A R QL+ E+ +L+ ++H+ Q+ + ++
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVE 514
Query: 1169 EEHSQELKEWREKLRPRKK 1187
+ + L ++E + P +K
Sbjct: 515 K---KPLYHYKEGMSPSEK 530
Score = 33.1 bits (74), Expect = 1.7
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 27/188 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYI 447
Query: 1194 ARKLQEQE 1201
R+L+E++
Sbjct: 448 RRQLEEEQ 455
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 891 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 950
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 951 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1010
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1011 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1070
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1071 GWITVGDLEGCIHYKVVKYERIKFLVI 1097
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 246 bits (628), Expect = 1e-64
Identities = 223/853 (26%), Positives = 372/853 (43%), Gaps = 105/853 (12%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 R-EKRPKLENLPD------TEDQETVDINSVSEGKENNIMITLE----------TNIEHN 466
R E+R + E+ + E+Q ++I E +++ + ++
Sbjct: 433 REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQ 492
Query: 467 LKSE------------EEKDQEKQQMFENKLIKSEEIKDTILQTVD--LVSQETGEKEAN 512
LK E E++ EK+ ++ K S K + + + + G
Sbjct: 493 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTA 552
Query: 513 IQAVDSEVGLTKEDTQEKLG------EDDKTQKDVISNTSDVIGTCEAAD---------- 556
Q+V + QE L E + D S + E D
Sbjct: 553 SQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED 612
Query: 557 ----VAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIE 612
V Q+ S + N +G +L ++P+ + PI E +
Sbjct: 613 IPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILE-SPLQRTS 671
Query: 613 EGKNKEQAINSSENIMDINEEPGTTEG-EEITESSSTEEMEVRSVVADTDQKALGSEVQD 671
G + + SS+ +PG+ G E T + + E V+ K E +D
Sbjct: 672 SGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRD 731
Query: 672 ASKVTTQIDKEK--KEIPVSIKKEPEVTVVSQPTEPQPVL--IPSININSDSGENKEEIG 727
++ + +K E ++ KE + + P + S + S+S E +EE G
Sbjct: 732 ITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDG 791
Query: 728 ---------SLSKTETILPPESENPKENDNDSGTGSTA-DTSSIDLNLSISSFLSKTKDS 777
++S ++P + E N G+ +TS D SF
Sbjct: 792 ESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHAD------SFSGSISRE 845
Query: 778 GSISLQETRRQKK 790
G++ ++ET +KK
Sbjct: 846 GTLMIRETSGEKK 858
Score = 58.9 bits (141), Expect = 3e-08
Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 32/203 (15%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKKEVINEV 933
E E +R E R +E +R + EQE ++L + Q L+ ++++++E
Sbjct: 420 ERE----------QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 934 EKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIEREC 993
+ RK+L ++R+ E Q Q QE++++ +Q Q+ E +E++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKP 517
Query: 994 LNNKQQLMRAREAAIWELEERHL 1016
L + ++ M E W E HL
Sbjct: 518 LYHYKEGMSPSEKPAWAKEIPHL 540
Score = 58.2 bits (139), Expect = 5e-08
Identities = 52/240 (21%), Positives = 117/240 (48%), Gaps = 25/240 (10%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQE 895
++EE+ + +S L E RR ++ +K+R E L +QQ + +R +E
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERS-----EALRRQQLEQQQRENEE 382
Query: 896 HTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955
H +L E ++ EQ+++ + + + R+KE+ + E+ + +E M RR+EE ++
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQRRHYEEQM-RREEERRRA 440
Query: 956 QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015
+H EQE++++Q +++++ +L ++++ L+ + L+ + +LEE+
Sbjct: 441 EH--EQEYIRRQ-----------LEEEQRQLEILQQQLLHEQALLLEYKRK---QLEEQR 484
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
E+ Q +Q +D +HQ ++ E + + Y + + K +E L ++
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVK 544
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 120/262 (45%), Gaps = 30/262 (11%)
Query: 701 QPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSS 760
QP E Q I + K++ G +TE E +E +NDSG + SS
Sbjct: 292 QPNERQV----RIQLKDHIDRTKKKRGEKDETEYEYSGSEE--EEEENDSG-----EPSS 340
Query: 761 IDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKT 820
I LNL S L + + LQ +++ + ++ E +++ + +
Sbjct: 341 I-LNLPGESTLRRD----FLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRI 395
Query: 821 EELRFLRR----QELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
EE + RR Q+ RE + L+K+++R +Q+ + + Q +RE+ RR E E +RQ ++
Sbjct: 396 EEQKEQRRRLEEQQRRE-KELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN--EVE 934
E LE Q+Q + H L E KR + E++++ + Q LK + +++
Sbjct: 454 EQRQLEILQQQLL------HEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 507
Query: 935 KAPKELRKELMKRRKEELAQSQ 956
+ + + K+ + KE ++ S+
Sbjct: 508 QEQRPVEKKPLYHYKEGMSPSE 529
Score = 45.4 bits (106), Expect = 3e-04
Identities = 62/278 (22%), Positives = 124/278 (44%), Gaps = 28/278 (10%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQ-----YF 1032
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1033 MQRHQLLKRHEKETEQMQRY---NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKS 1089
M+R + +R E E E ++R QR +E L+ + E+A L + +R + + + +
Sbjct: 431 MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQ 490
Query: 1090 LRINSTATPDQDRDKIKQFAAQ-EEKRQKNERMAQHQK 1126
++ Q+RD + Q +E+R ++ H K
Sbjct: 491 RQLK------QERDYLVSLQHQRQEQRPVEKKPLYHYK 522
Score = 38.5 bits (88), Expect = 0.040
Identities = 68/319 (21%), Positives = 142/319 (44%), Gaps = 67/319 (21%)
Query: 901 RDEAKRIKGEQEKELSKFQN-----MLKNRKKEVINE-------VEKAPKE------LRK 942
R+ A R+K + K KFQ+ ++KN + E + P E L+
Sbjct: 247 RNPAPRLKSK--KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKD 304
Query: 943 ELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLN----NKQ 998
+ + +K+ + + E +++++E D I E + + R+ L NK+
Sbjct: 305 HIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE-STLRRDFLRLQLANKE 363
Query: 999 QLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYN--QRL 1056
+ R + + + + + K QLL ++ K R E++ EQ +R QR
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------------RIEEQKEQRRRLEEQQRR 411
Query: 1057 IEELKNRQTQERARLPKIQ-RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKR 1115
+EL+ +Q +E+ R + Q R E + R A + +++ I++ EE++
Sbjct: 412 EKELRKQQEREQRRHYEEQMRREEERRRA--------------EHEQEYIRR--QLEEEQ 455
Query: 1116 QKNERMAQHQKHENQM------RDLQLQCEANVRELHQLQNEKCHLL-VEHETQKLKELD 1168
++ E + Q HE + + L+ Q +A R QL+ E+ +L+ ++H+ Q+ + ++
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVE 514
Query: 1169 EEHSQELKEWREKLRPRKK 1187
+ + L ++E + P +K
Sbjct: 515 K---KPLYHYKEGMSPSEK 530
Score = 33.1 bits (74), Expect = 1.7
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 27/188 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYI 447
Query: 1194 ARKLQEQE 1201
R+L+E++
Sbjct: 448 RRQLEEEQ 455
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 899 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 958
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 959 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1018
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1019 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1078
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1079 GWITVGDLEGCIHYKVVKYERIKFLVI 1105
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 244 bits (624), Expect = 3e-64
Identities = 152/481 (31%), Positives = 251/481 (52%), Gaps = 32/481 (6%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
RE+ + ++ ++ +E + + + + + +E++ EK+ ++
Sbjct: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
Query: 484 K 484
K
Sbjct: 493 K 493
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 25/288 (8%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSL 1090
+ + HE+E ++ Q QR E L+ + QER L +Q + R K
Sbjct: 431 MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLY 490
Query: 1091 RINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHE--NQMRDLQL 1136
+P + K+ EE+ + N + + H+ N++ D L
Sbjct: 491 HYKEGMSPSEKPAWAKEV---EERSRLNRQSSPAMPHKVANRISDPNL 535
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/191 (26%), Positives = 95/191 (49%), Gaps = 21/191 (10%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQ- 894
++EE+ + +S L E RR ++ +K+R + LE+QQ++ E Q
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQL 387
Query: 895 --EHTNRL---RDEAKRIKGEQ--EKELSKFQNMLKNR--KKEVINEVEKAPKELRKELM 945
E R+ +++ +R++ +Q EKEL K Q + R ++++ E E+ E +E
Sbjct: 388 LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
+++ EE Q++ Q Q KQ+++ SL Q Q+ E +E++ L + ++ M E
Sbjct: 448 RKQLEEQRQAERLQRQ---LKQERDYLVSL----QHQRQEQRPVEKKPLYHYKEGMSPSE 500
Query: 1006 AAIW--ELEER 1014
W E+EER
Sbjct: 501 KPAWAKEVEER 511
Score = 47.4 bits (111), Expect = 9e-05
Identities = 44/163 (26%), Positives = 79/163 (48%), Gaps = 24/163 (14%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931
E E + E+Q ++ ER EH E KR + E++++ + Q LK + +++
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 932 -------EVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 967
VEK P KE M E+ A ++ +E+ + +Q
Sbjct: 476 HQRQEQRPVEKKPLYHYKEGMS-PSEKPAWAKEVEERSRLNRQ 517
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/190 (23%), Positives = 98/190 (51%), Gaps = 37/190 (19%)
Query: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072
+ L+ QL K++ R Q L++ ++E E+ +R Q+ IEE Q ++R RL
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
Query: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
+ QR E + R Q+R++ + + +E+ R++ ER + +HE + +
Sbjct: 407 EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
Query: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKKTLE 1190
QL+ + L QL+ E+ +L+ ++H+ Q+ + +++ + L ++E + P +K
Sbjct: 448 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK--- 501
Query: 1191 EEFARKLQEQ 1200
+A++++E+
Sbjct: 502 PAWAKEVEER 511
Score = 32.7 bits (73), Expect = 2.2
Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 29/139 (20%)
Query: 782 LQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEE 841
L+E +R++K L+K ++ + + + EE R R + +E + Q EE
Sbjct: 405 LEEQQRREKELRKQQE----------REQRRHYEEQMRREEER-RRAEHEQEYKRKQLEE 453
Query: 842 QRAQQQLNSKLQQQREQIF----RRFEQEMMSKKRQY--------------DQEIENLEK 883
QR ++L +L+Q+R+ + +R EQ + KK Y +E+E +
Sbjct: 454 QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSR 513
Query: 884 QQKQTIERLEQEHTNRLRD 902
+Q+ + + NR+ D
Sbjct: 514 LNRQSSPAMPHKVANRISD 532
Score = 31.2 bits (69), Expect = 6.4
Identities = 40/187 (21%), Positives = 79/187 (42%), Gaps = 27/187 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 1194 ARKLQEQ 1200
++L+EQ
Sbjct: 448 RKQLEEQ 454
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 917 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 976
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 977 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1036
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1037 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1096
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1097 GWITVGDLEGCIHYKVVKYERIKFLVI 1123
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 244 bits (624), Expect = 3e-64
Identities = 152/481 (31%), Positives = 251/481 (52%), Gaps = 32/481 (6%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R ++
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
RE+ + ++ ++ +E + + + + + +E++ EK+ ++
Sbjct: 433 REEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHY 492
Query: 484 K 484
K
Sbjct: 493 K 493
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 25/288 (8%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQ 1037
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1038 LLK-------RHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSL 1090
+ + HE+E ++ Q QR E L+ + QER L +Q + R K
Sbjct: 431 MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLY 490
Query: 1091 RINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHE--NQMRDLQL 1136
+P + K+ EE+ + N + + H+ N++ D L
Sbjct: 491 HYKEGMSPSEKPAWAKEV---EERSRLNRQSSPAMPHKVANRISDPNL 535
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/191 (26%), Positives = 95/191 (49%), Gaps = 21/191 (10%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQ- 894
++EE+ + +S L E RR ++ +K+R + LE+QQ++ E Q
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQL 387
Query: 895 --EHTNRL---RDEAKRIKGEQ--EKELSKFQNMLKNR--KKEVINEVEKAPKELRKELM 945
E R+ +++ +R++ +Q EKEL K Q + R ++++ E E+ E +E
Sbjct: 388 LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
+++ EE Q++ Q Q KQ+++ SL Q Q+ E +E++ L + ++ M E
Sbjct: 448 RKQLEEQRQAERLQRQ---LKQERDYLVSL----QHQRQEQRPVEKKPLYHYKEGMSPSE 500
Query: 1006 AAIW--ELEER 1014
W E+EER
Sbjct: 501 KPAWAKEVEER 511
Score = 47.4 bits (111), Expect = 9e-05
Identities = 44/163 (26%), Positives = 79/163 (48%), Gaps = 24/163 (14%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIE---NLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN-- 931
E E + E+Q ++ ER EH E KR + E++++ + Q LK + +++
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH----EQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 932 -------EVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 967
VEK P KE M E+ A ++ +E+ + +Q
Sbjct: 476 HQRQEQRPVEKKPLYHYKEGMS-PSEKPAWAKEVEERSRLNRQ 517
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/190 (23%), Positives = 98/190 (51%), Gaps = 37/190 (19%)
Query: 1019 KHQLLKQQL--KDQYFMQRHQLLKRHEKETEQMQRY----NQRLIEELKNRQTQERARLP 1072
+ L+ QL K++ R Q L++ ++E E+ +R Q+ IEE Q ++R RL
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE----QKEQRRRLE 406
Query: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
+ QR E + R Q+R++ + + +E+ R++ ER + +HE + +
Sbjct: 407 EQQRREKELRK---------------QQEREQRRHY--EEQMRREEER--RRAEHEQEYK 447
Query: 1133 DLQLQCEANVREL-HQLQNEKCHLL-VEHETQKLKELDEEHSQELKEWREKLRPRKKTLE 1190
QL+ + L QL+ E+ +L+ ++H+ Q+ + +++ + L ++E + P +K
Sbjct: 448 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK---KPLYHYKEGMSPSEK--- 501
Query: 1191 EEFARKLQEQ 1200
+A++++E+
Sbjct: 502 PAWAKEVEER 511
Score = 32.7 bits (73), Expect = 2.2
Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 29/139 (20%)
Query: 782 LQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEE 841
L+E +R++K L+K ++ + + + EE R R + +E + Q EE
Sbjct: 405 LEEQQRREKELRKQQE----------REQRRHYEEQMRREEER-RRAEHEQEYKRKQLEE 453
Query: 842 QRAQQQLNSKLQQQREQIF----RRFEQEMMSKKRQY--------------DQEIENLEK 883
QR ++L +L+Q+R+ + +R EQ + KK Y +E+E +
Sbjct: 454 QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSR 513
Query: 884 QQKQTIERLEQEHTNRLRD 902
+Q+ + + NR+ D
Sbjct: 514 LNRQSSPAMPHKVANRISD 532
Score = 31.2 bits (69), Expect = 6.4
Identities = 40/187 (21%), Positives = 79/187 (42%), Gaps = 27/187 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYK 447
Query: 1194 ARKLQEQ 1200
++L+EQ
Sbjct: 448 RKQLEEQ 454
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 925 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 984
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 985 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1044
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1045 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1104
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1105 GWITVGDLEGCIHYKVVKYERIKFLVI 1131
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 244 bits (622), Expect = 5e-64
Identities = 158/493 (32%), Positives = 256/493 (51%), Gaps = 36/493 (7%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R + E
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYE 428
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
+ R + E +QE + E ++ I+ + + L + K E+Q+ E
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488
Query: 484 KLIKSEEIKDTIL 496
+ ++ +D ++
Sbjct: 489 LQRQLKQERDYLV 501
Score = 61.2 bits (147), Expect = 6e-09
Identities = 54/239 (22%), Positives = 120/239 (50%), Gaps = 28/239 (11%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQE 895
++EE+ + +S L E RR ++ +K+R E L +QQ + +R +E
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERS-----EALRRQQLEQQQRENEE 382
Query: 896 HTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955
H +L E ++ EQ+++ + + + R+KE+ + E+ + +E M RR+EE ++
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQRRHYEEQM-RREEERRRA 440
Query: 956 QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015
+H EQE++++Q +++++ +L ++++ L+ + L+ + +LEE+
Sbjct: 441 EH--EQEYIRRQ-----------LEEEQRQLEILQQQLLHEQALLLEYKRK---QLEEQR 484
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARL 1071
E+ Q +Q +D +HQ ++ E + + Y + + K ++ +ER+RL
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRL 543
Score = 58.5 bits (140), Expect = 4e-08
Identities = 53/203 (26%), Positives = 99/203 (48%), Gaps = 34/203 (16%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKKEVINEV 933
E E +R E R +E +R + EQE ++L + Q L+ ++++++E
Sbjct: 420 ERE----------QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 934 EKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIEREC 993
+ RK+L ++R+ E Q Q QE++++ +Q Q+ E +E++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKP 517
Query: 994 LNNKQQLMRAREAAIW--ELEER 1014
L + ++ M E W E+EER
Sbjct: 518 LYHYKEGMSPSEKPAWAKEVEER 540
Score = 53.1 bits (126), Expect = 2e-06
Identities = 71/280 (25%), Positives = 126/280 (45%), Gaps = 38/280 (13%)
Query: 701 QPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSS 760
QP E Q I + K++ G +TE E +E +NDSG + SS
Sbjct: 292 QPNERQV----RIQLKDHIDRTKKKRGEKDETEYEYSGSEE--EEEENDSG-----EPSS 340
Query: 761 IDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKT 820
I LNL S L + + LQ +++ + ++ E +++ + +
Sbjct: 341 I-LNLPGESTLRRD----FLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRI 395
Query: 821 EELRFLRR----QELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
EE + RR Q+ RE + L+K+++R +Q+ + + Q +RE+ RR E E +RQ ++
Sbjct: 396 EEQKEQRRRLEEQQRRE-KELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN----- 931
E LE Q+Q + H L E KR + E++++ + Q LK + +++
Sbjct: 454 EQRQLEILQQQLL------HEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 507
Query: 932 ----EVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 967
VEK P KE M E+ A ++ +E+ + +Q
Sbjct: 508 QEQRPVEKKPLYHYKEGMS-PSEKPAWAKEVEERSRLNRQ 546
Score = 45.4 bits (106), Expect = 3e-04
Identities = 62/278 (22%), Positives = 124/278 (44%), Gaps = 28/278 (10%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQ-----YF 1032
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1033 MQRHQLLKRHEKETEQMQRY---NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKS 1089
M+R + +R E E E ++R QR +E L+ + E+A L + +R + + + +
Sbjct: 431 MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQ 490
Query: 1090 LRINSTATPDQDRDKIKQFAAQ-EEKRQKNERMAQHQK 1126
++ Q+RD + Q +E+R ++ H K
Sbjct: 491 RQLK------QERDYLVSLQHQRQEQRPVEKKPLYHYK 522
Score = 38.9 bits (89), Expect = 0.031
Identities = 70/332 (21%), Positives = 150/332 (45%), Gaps = 70/332 (21%)
Query: 901 RDEAKRIKGEQEKELSKFQN-----MLKNRKKEVINE-------VEKAPKE------LRK 942
R+ A R+K + K KFQ+ ++KN + E + P E L+
Sbjct: 247 RNPAPRLKSK--KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKD 304
Query: 943 ELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLN----NKQ 998
+ + +K+ + + E +++++E D I E + + R+ L NK+
Sbjct: 305 HIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE-STLRRDFLRLQLANKE 363
Query: 999 QLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYN--QRL 1056
+ R + + + + + K QLL ++ K R E++ EQ +R QR
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------------RIEEQKEQRRRLEEQQRR 411
Query: 1057 IEELKNRQTQERARLPKIQ-RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKR 1115
+EL+ +Q +E+ R + Q R E + R A + +++ I++ EE++
Sbjct: 412 EKELRKQQEREQRRHYEEQMRREEERRRA--------------EHEQEYIRR--QLEEEQ 455
Query: 1116 QKNERMAQHQKHENQM------RDLQLQCEANVRELHQLQNEKCHLL-VEHETQKLKELD 1168
++ E + Q HE + + L+ Q +A R QL+ E+ +L+ ++H+ Q+ + ++
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVE 514
Query: 1169 EEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 1200
+ + L ++E + P +K +A++++E+
Sbjct: 515 K---KPLYHYKEGMSPSEK---PAWAKEVEER 540
Score = 33.1 bits (74), Expect = 1.7
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 27/188 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYI 447
Query: 1194 ARKLQEQE 1201
R+L+E++
Sbjct: 448 RRQLEEEQ 455
Score = 32.3 bits (72), Expect = 2.9
Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 24/110 (21%)
Query: 817 DSKTEELRFLRRQELRELRFL------QKEEQRAQQQLNSKLQQQREQIF----RRFEQE 866
+ + +L L++Q L E L Q EEQR ++L +L+Q+R+ + +R EQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Query: 867 MMSKKRQY--------------DQEIENLEKQQKQTIERLEQEHTNRLRD 902
+ KK Y +E+E + +Q+ + + NR+ D
Sbjct: 512 PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 561
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 946 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 1005
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 1006 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1065
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1066 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1125
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1126 GWITVGDLEGCIHYKVVKYERIKFLVI 1152
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 244 bits (622), Expect = 5e-64
Identities = 158/493 (32%), Positives = 256/493 (51%), Gaps = 36/493 (7%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYYEN------NLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +N LW+++EFC G+V D + L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L++LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YD+K+D+WSLGIT IEMAE PP +++PMR L I ++ P L + +
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK-----PIRELIAEAK-----AE 310
WS F+ F++ CL KN R T QL++HPF+ N+ +++ I K +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
Query: 311 VTEEVEDGKEEDEEE----ETENSLPIPASKRASSD---LSIASSEEDKLSQNACILESV 363
TE G EE+EEE E + L +P D L +A+ E ++ +
Sbjct: 318 ETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKE-----RSEALRRQQ 372
Query: 364 SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENE 423
E+ +R N E K +K ++ E+ + + +L E R + E
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR----RHYE 428
Query: 424 REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFEN 483
+ R + E +QE + E ++ I+ + + L + K E+Q+ E
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488
Query: 484 KLIKSEEIKDTIL 496
+ ++ +D ++
Sbjct: 489 LQRQLKQERDYLV 501
Score = 61.2 bits (147), Expect = 6e-09
Identities = 54/239 (22%), Positives = 120/239 (50%), Gaps = 28/239 (11%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRR--FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQE 895
++EE+ + +S L E RR ++ +K+R E L +QQ + +R +E
Sbjct: 328 EEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERS-----EALRRQQLEQQQRENEE 382
Query: 896 HTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQS 955
H +L E ++ EQ+++ + + + R+KE+ + E+ + +E M RR+EE ++
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQRRHYEEQM-RREEERRRA 440
Query: 956 QHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERH 1015
+H EQE++++Q +++++ +L ++++ L+ + L+ + +LEE+
Sbjct: 441 EH--EQEYIRRQ-----------LEEEQRQLEILQQQLLHEQALLLEYKRK---QLEEQR 484
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARL 1071
E+ Q +Q +D +HQ ++ E + + Y + + K ++ +ER+RL
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRL 543
Score = 58.5 bits (140), Expect = 4e-08
Identities = 53/203 (26%), Positives = 99/203 (48%), Gaps = 34/203 (16%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL----NSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
E LRRQ+L + Q+E + ++QL ++++Q+EQ R EQ+ K+ + Q
Sbjct: 363 ERSEALRRQQLEQ---QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKKEVINEV 933
E E +R E R +E +R + EQE ++L + Q L+ ++++++E
Sbjct: 420 ERE----------QRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 934 EKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIEREC 993
+ RK+L ++R+ E Q Q QE++++ +Q Q+ E +E++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVS------------LQHQRQEQRPVEKKP 517
Query: 994 LNNKQQLMRAREAAIW--ELEER 1014
L + ++ M E W E+EER
Sbjct: 518 LYHYKEGMSPSEKPAWAKEVEER 540
Score = 53.1 bits (126), Expect = 2e-06
Identities = 71/280 (25%), Positives = 126/280 (45%), Gaps = 38/280 (13%)
Query: 701 QPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSS 760
QP E Q I + K++ G +TE E +E +NDSG + SS
Sbjct: 292 QPNERQV----RIQLKDHIDRTKKKRGEKDETEYEYSGSEE--EEEENDSG-----EPSS 340
Query: 761 IDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKT 820
I LNL S L + + LQ +++ + ++ E +++ + +
Sbjct: 341 I-LNLPGESTLRRD----FLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRI 395
Query: 821 EELRFLRR----QELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQ 876
EE + RR Q+ RE + L+K+++R +Q+ + + Q +RE+ RR E E +RQ ++
Sbjct: 396 EEQKEQRRRLEEQQRRE-KELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVIN----- 931
E LE Q+Q + H L E KR + E++++ + Q LK + +++
Sbjct: 454 EQRQLEILQQQLL------HEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 507
Query: 932 ----EVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 967
VEK P KE M E+ A ++ +E+ + +Q
Sbjct: 508 QEQRPVEKKPLYHYKEGMS-PSEKPAWAKEVEERSRLNRQ 546
Score = 45.4 bits (106), Expect = 3e-04
Identities = 62/278 (22%), Positives = 124/278 (44%), Gaps = 28/278 (10%)
Query: 860 FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQ-EKELSKF 918
F+ F + + K E L K + E++ +L+D R K ++ EK+ +++
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY 321
Query: 919 QNMLKNRKKEVINEVEKAP-KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKK 977
+ ++E + E + L E RR Q + + E +++QQ
Sbjct: 322 EYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ--------- 372
Query: 978 IIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQ-----YF 1032
++QQ+ E +R+ L +Q+ + ++ LEE+ +EK +L KQQ ++Q
Sbjct: 373 -LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-ELRKQQEREQRRHYEEQ 430
Query: 1033 MQRHQLLKRHEKETEQMQRY---NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKS 1089
M+R + +R E E E ++R QR +E L+ + E+A L + +R + + + +
Sbjct: 431 MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQ 490
Query: 1090 LRINSTATPDQDRDKIKQFAAQ-EEKRQKNERMAQHQK 1126
++ Q+RD + Q +E+R ++ H K
Sbjct: 491 RQLK------QERDYLVSLQHQRQEQRPVEKKPLYHYK 522
Score = 38.9 bits (89), Expect = 0.031
Identities = 70/332 (21%), Positives = 150/332 (45%), Gaps = 70/332 (21%)
Query: 901 RDEAKRIKGEQEKELSKFQN-----MLKNRKKEVINE-------VEKAPKE------LRK 942
R+ A R+K + K KFQ+ ++KN + E + P E L+
Sbjct: 247 RNPAPRLKSK--KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKD 304
Query: 943 ELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLN----NKQ 998
+ + +K+ + + E +++++E D I E + + R+ L NK+
Sbjct: 305 HIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGE-STLRRDFLRLQLANKE 363
Query: 999 QLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYN--QRL 1056
+ R + + + + + K QLL ++ K R E++ EQ +R QR
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------------RIEEQKEQRRRLEEQQRR 411
Query: 1057 IEELKNRQTQERARLPKIQ-RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKR 1115
+EL+ +Q +E+ R + Q R E + R A + +++ I++ EE++
Sbjct: 412 EKELRKQQEREQRRHYEEQMRREEERRRA--------------EHEQEYIRR--QLEEEQ 455
Query: 1116 QKNERMAQHQKHENQM------RDLQLQCEANVRELHQLQNEKCHLL-VEHETQKLKELD 1168
++ E + Q HE + + L+ Q +A R QL+ E+ +L+ ++H+ Q+ + ++
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVE 514
Query: 1169 EEHSQELKEWREKLRPRKKTLEEEFARKLQEQ 1200
+ + L ++E + P +K +A++++E+
Sbjct: 515 K---KPLYHYKEGMSPSEK---PAWAKEVEER 540
Score = 33.1 bits (74), Expect = 1.7
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 27/188 (14%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP---K 1073
Q + ++ QLKD + R + + + ETE ++ EE + + LP
Sbjct: 292 QPNERQVRIQLKDH--IDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGEST 349
Query: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRD 1133
++R + ++A ++S + Q R+ +E KRQ +A+ QK + ++
Sbjct: 350 LRRDFLRLQLANKERSEALRRQQLEQQQREN------EEHKRQL---LAERQKRIEEQKE 400
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
+ + E R E E +K +E ++ E + RE+ R R + +E
Sbjct: 401 QRRRLEEQQRR-------------EKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYI 447
Query: 1194 ARKLQEQE 1201
R+L+E++
Sbjct: 448 RRQLEEEQ 455
Score = 32.3 bits (72), Expect = 2.9
Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 24/110 (21%)
Query: 817 DSKTEELRFLRRQELRELRFL------QKEEQRAQQQLNSKLQQQREQIF----RRFEQE 866
+ + +L L++Q L E L Q EEQR ++L +L+Q+R+ + +R EQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Query: 867 MMSKKRQY--------------DQEIENLEKQQKQTIERLEQEHTNRLRD 902
+ KK Y +E+E + +Q+ + + NR+ D
Sbjct: 512 PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 561
Score = 30.8 bits (68), Expect = 8.3
Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 22/207 (10%)
Query: 312 TEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSN 371
++E++ G E T+ S R EED+ S A + S + E++
Sbjct: 954 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 1013
Query: 372 SEDKLNSKILNEKPT-----TDEPE--KAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
+ ++N PT +D PE K + N I A L + L + +R
Sbjct: 1014 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1073
Query: 425 EKRPKLENLPDTEDQETVDINS------VSEGKENNIMI----TLETNIEHNLKSEEEKD 474
+ K+ NL + + +D+ GK+N + + L I HN E+K
Sbjct: 1074 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1133
Query: 475 -----QEKQQMFENKLIKSEEIKDTIL 496
+ + K++K E IK ++
Sbjct: 1134 GWITVGDLEGCIHYKVVKYERIKFLVI 1160
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 243 bits (620), Expect = 8e-64
Identities = 181/610 (29%), Positives = 298/610 (48%), Gaps = 50/610 (8%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYY------ENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF ++ LW+++EFC G+V D V L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WSLGIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F DF+ CL K +R T QLL+ PF+ + R++ + K + K+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTE--RQVRIQLKDHID---RSRKK 312
Query: 321 EDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKI 380
E+EETE S D S E N ++ + R E+K NS+
Sbjct: 313 RGEKEETEYEY----SGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEA 368
Query: 381 LNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQE 440
L ++ + ++ D HI LH R I+E + E+R E +Q
Sbjct: 369 LKQQQQLQQQQQ--RDPEAHIKHL-------LHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 441 TVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVD 500
+ +E LE +++ + EE + E++Q ++ K ++ + + + + +
Sbjct: 420 KL--------QEKEQQRRLE-DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQL- 469
Query: 501 LVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQK 560
Q+ ++Q + L K+ Q+ L D K + + + + A++
Sbjct: 470 ---QQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP----LYHYGRGMNPADKPAWARE 522
Query: 561 VDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMN---EIEEGKNK 617
V+E + + Q N + G P+ P+A P+ + M E +EG +K
Sbjct: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPI--PQASPGPPGPLSQTPPMQRPVEPQEGPHK 580
Query: 618 EQAINSSENI 627
+ N+
Sbjct: 581 SLQDQPTRNL 590
Score = 60.8 bits (146), Expect = 8e-09
Identities = 53/224 (23%), Positives = 111/224 (49%), Gaps = 26/224 (11%)
Query: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
F ++ ++++ Q +++++ +K+ E+ E E+ +E GE E E S N+
Sbjct: 288 FIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNV- 345
Query: 923 KNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQ-ELDGSLKKIIQQ 981
LR+E ++ ++E + S+ ++Q+ +Q+QQQ + + +K ++ Q
Sbjct: 346 ------------PGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 982 QKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKR 1041
+ +R K++ R E E E+R LQEK Q +++L+D ++R + ++
Sbjct: 394 R-------QRRIEEQKEERRRVEEQQRREREQRKLQEKEQ--QRRLEDMQALRREEERRQ 444
Query: 1042 HEKETE--QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRM 1083
E+E E + Q QR E L+ + QE A L +Q+ + + ++
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQL 488
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/222 (24%), Positives = 96/222 (43%), Gaps = 38/222 (17%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S I+ T FLR Q+ L++ + LQ+++QR + L QR++
Sbjct: 340 SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIE 399
Query: 862 RFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNM 921
++E + Q +E E + Q+K+ RLE LR E +R + E+E+E +
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLED--MQALRREEERRQAEREQEYKR---- 453
Query: 922 LKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQ 981
K+L ++ R + Q +HA + Q+QQQ+ ++ +Q
Sbjct: 454 ----------------KQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ------QLQKQ 491
Query: 982 QKAELANIERECLNNKQQLMRAREAAIW--ELEERHLQEKHQ 1021
Q+ +L +R+ L + + M + W E+EER K Q
Sbjct: 492 QQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQ 533
Score = 50.8 bits (120), Expect = 8e-06
Identities = 59/292 (20%), Positives = 136/292 (46%), Gaps = 19/292 (6%)
Query: 793 KKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL-RELRFLQKEE-QRAQQQLNS 850
KK K +D ++ + + + + + F+R Q R++R K+ R++++
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 851 KLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGE 910
K + + E E + ++ + I N+ + E L + N+ EA +
Sbjct: 316 KEETEYEYSGSEEEDDSHGEEGE-PSSIMNVPGESTLRREFLRLQQENKSNSEALK---- 370
Query: 911 QEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
Q+++L + Q ++ + + + + + + + ++ +RR+ E Q + ++++ +K+QQ
Sbjct: 371 QQQQLQQQQQ--RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428
Query: 971 LDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLK--QQLK 1028
++ + ++++ A ERE ++QL R++ E +R LQ++H LK QQ +
Sbjct: 429 RLEDMQALRREEERRQA--EREQEYKRKQLEEQRQS---ERLQRQLQQEHAYLKSLQQQQ 483
Query: 1029 DQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARLPKIQRS 1077
Q +Q+ Q + + + + Y + + K R+ +ER R+ K Q S
Sbjct: 484 QQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 21/160 (13%)
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
LQ++++ + LK Q +Q+ Q + E + + QR IEE Q +ER R+ + Q
Sbjct: 358 LQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQQ 412
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQ 1135
R E + R K+ R R + Q +EE+R++ ER Q+++ + + Q
Sbjct: 413 RREREQRKLQEKEQQR----------RLEDMQALRREEERRQAER---EQEYKRKQLEEQ 459
Query: 1136 LQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Q E R QLQ E +L + Q+ ++L ++ Q+L
Sbjct: 460 RQSE---RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/91 (25%), Positives = 47/91 (51%), Gaps = 15/91 (16%)
Query: 1111 QEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEE 1170
Q+E + +E + Q Q+ + Q Q EA+++ HLL H+ Q+ E +E
Sbjct: 359 QQENKSNSEALKQQQQLQQQQ---QRDPEAHIK----------HLL--HQRQRRIEEQKE 403
Query: 1171 HSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
+ ++E + + R ++K E+E R+L++ +
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQ 434
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 242 bits (618), Expect = 1e-63
Identities = 180/600 (30%), Positives = 295/600 (49%), Gaps = 50/600 (8%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYY------ENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF ++ LW+++EFC G+V D V L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WSLGIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F DF+ CL K +R T QLL+ PF+ + R++ + K + K+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTE--RQVRIQLKDHID---RSRKK 312
Query: 321 EDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKI 380
E+EETE S D S E N ++ + R E+K NS+
Sbjct: 313 RGEKEETEYEY----SGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEA 368
Query: 381 LNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQE 440
L ++ + ++ D HI LH R I+E + E+R E +Q
Sbjct: 369 LKQQQQLQQQQQ--RDPEAHIKHL-------LHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 441 TVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVD 500
+ +E LE +++ + EE + E++Q ++ K ++ + + + + +
Sbjct: 420 KL--------QEKEQQRRLE-DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQL- 469
Query: 501 LVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQK 560
Q+ ++Q + L K+ Q+ L D K + + + + A++
Sbjct: 470 ---QQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP----LYHYGRGMNPADKPAWARE 522
Query: 561 VDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMN---EIEEGKNK 617
V+E + + Q N + G P+ P+A P+ + M E +EG +K
Sbjct: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPI--PQASPGPPGPLSQTPPMQRPVEPQEGPHK 580
Score = 60.8 bits (146), Expect = 8e-09
Identities = 53/224 (23%), Positives = 111/224 (49%), Gaps = 26/224 (11%)
Query: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
F ++ ++++ Q +++++ +K+ E+ E E+ +E GE E E S N+
Sbjct: 288 FIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNV- 345
Query: 923 KNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQ-ELDGSLKKIIQQ 981
LR+E ++ ++E + S+ ++Q+ +Q+QQQ + + +K ++ Q
Sbjct: 346 ------------PGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 982 QKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKR 1041
+ +R K++ R E E E+R LQEK Q +++L+D ++R + ++
Sbjct: 394 R-------QRRIEEQKEERRRVEEQQRREREQRKLQEKEQ--QRRLEDMQALRREEERRQ 444
Query: 1042 HEKETE--QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRM 1083
E+E E + Q QR E L+ + QE A L +Q+ + + ++
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQL 488
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/222 (24%), Positives = 96/222 (43%), Gaps = 38/222 (17%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S I+ T FLR Q+ L++ + LQ+++QR + L QR++
Sbjct: 340 SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIE 399
Query: 862 RFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNM 921
++E + Q +E E + Q+K+ RLE LR E +R + E+E+E +
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLED--MQALRREEERRQAEREQEYKR---- 453
Query: 922 LKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQ 981
K+L ++ R + Q +HA + Q+QQQ+ ++ +Q
Sbjct: 454 ----------------KQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ------QLQKQ 491
Query: 982 QKAELANIERECLNNKQQLMRAREAAIW--ELEERHLQEKHQ 1021
Q+ +L +R+ L + + M + W E+EER K Q
Sbjct: 492 QQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQ 533
Score = 50.8 bits (120), Expect = 8e-06
Identities = 59/292 (20%), Positives = 136/292 (46%), Gaps = 19/292 (6%)
Query: 793 KKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL-RELRFLQKEE-QRAQQQLNS 850
KK K +D ++ + + + + + F+R Q R++R K+ R++++
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 851 KLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGE 910
K + + E E + ++ + I N+ + E L + N+ EA +
Sbjct: 316 KEETEYEYSGSEEEDDSHGEEGE-PSSIMNVPGESTLRREFLRLQQENKSNSEALK---- 370
Query: 911 QEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
Q+++L + Q ++ + + + + + + + ++ +RR+ E Q + ++++ +K+QQ
Sbjct: 371 QQQQLQQQQQ--RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428
Query: 971 LDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLK--QQLK 1028
++ + ++++ A ERE ++QL R++ E +R LQ++H LK QQ +
Sbjct: 429 RLEDMQALRREEERRQA--EREQEYKRKQLEEQRQS---ERLQRQLQQEHAYLKSLQQQQ 483
Query: 1029 DQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARLPKIQRS 1077
Q +Q+ Q + + + + Y + + K R+ +ER R+ K Q S
Sbjct: 484 QQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 21/160 (13%)
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
LQ++++ + LK Q +Q+ Q + E + + QR IEE Q +ER R+ + Q
Sbjct: 358 LQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQQ 412
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQ 1135
R E + R K+ R R + Q +EE+R++ ER Q+++ + + Q
Sbjct: 413 RREREQRKLQEKEQQR----------RLEDMQALRREEERRQAER---EQEYKRKQLEEQ 459
Query: 1136 LQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Q E R QLQ E +L + Q+ ++L ++ Q+L
Sbjct: 460 RQSE---RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/91 (25%), Positives = 47/91 (51%), Gaps = 15/91 (16%)
Query: 1111 QEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEE 1170
Q+E + +E + Q Q+ + Q Q EA+++ HLL H+ Q+ E +E
Sbjct: 359 QQENKSNSEALKQQQQLQQQQ---QRDPEAHIK----------HLL--HQRQRRIEEQKE 403
Query: 1171 HSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
+ ++E + + R ++K E+E R+L++ +
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQ 434
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 242 bits (618), Expect = 1e-63
Identities = 180/600 (30%), Positives = 295/600 (49%), Gaps = 50/600 (8%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYY------ENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF ++ LW+++EFC G+V D V L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WSLGIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F DF+ CL K +R T QLL+ PF+ + R++ + K + K+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTE--RQVRIQLKDHID---RSRKK 312
Query: 321 EDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKI 380
E+EETE S D S E N ++ + R E+K NS+
Sbjct: 313 RGEKEETEYEY----SGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEA 368
Query: 381 LNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQE 440
L ++ + ++ D HI LH R I+E + E+R E +Q
Sbjct: 369 LKQQQQLQQQQQ--RDPEAHIKHL-------LHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 441 TVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVD 500
+ +E LE +++ + EE + E++Q ++ K ++ + + + + +
Sbjct: 420 KL--------QEKEQQRRLE-DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQL- 469
Query: 501 LVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQK 560
Q+ ++Q + L K+ Q+ L D K + + + + A++
Sbjct: 470 ---QQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP----LYHYGRGMNPADKPAWARE 522
Query: 561 VDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMN---EIEEGKNK 617
V+E + + Q N + G P+ P+A P+ + M E +EG +K
Sbjct: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPI--PQASPGPPGPLSQTPPMQRPVEPQEGPHK 580
Score = 60.8 bits (146), Expect = 8e-09
Identities = 53/224 (23%), Positives = 111/224 (49%), Gaps = 26/224 (11%)
Query: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
F ++ ++++ Q +++++ +K+ E+ E E+ +E GE E E S N+
Sbjct: 288 FIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNV- 345
Query: 923 KNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQ-ELDGSLKKIIQQ 981
LR+E ++ ++E + S+ ++Q+ +Q+QQQ + + +K ++ Q
Sbjct: 346 ------------PGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 982 QKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKR 1041
+ +R K++ R E E E+R LQEK Q +++L+D ++R + ++
Sbjct: 394 R-------QRRIEEQKEERRRVEEQQRREREQRKLQEKEQ--QRRLEDMQALRREEERRQ 444
Query: 1042 HEKETE--QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRM 1083
E+E E + Q QR E L+ + QE A L +Q+ + + ++
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQL 488
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/222 (24%), Positives = 96/222 (43%), Gaps = 38/222 (17%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S I+ T FLR Q+ L++ + LQ+++QR + L QR++
Sbjct: 340 SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIE 399
Query: 862 RFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNM 921
++E + Q +E E + Q+K+ RLE LR E +R + E+E+E +
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLED--MQALRREEERRQAEREQEYKR---- 453
Query: 922 LKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQ 981
K+L ++ R + Q +HA + Q+QQQ+ ++ +Q
Sbjct: 454 ----------------KQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ------QLQKQ 491
Query: 982 QKAELANIERECLNNKQQLMRAREAAIW--ELEERHLQEKHQ 1021
Q+ +L +R+ L + + M + W E+EER K Q
Sbjct: 492 QQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQ 533
Score = 50.8 bits (120), Expect = 8e-06
Identities = 59/292 (20%), Positives = 136/292 (46%), Gaps = 19/292 (6%)
Query: 793 KKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL-RELRFLQKEE-QRAQQQLNS 850
KK K +D ++ + + + + + F+R Q R++R K+ R++++
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 851 KLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGE 910
K + + E E + ++ + I N+ + E L + N+ EA +
Sbjct: 316 KEETEYEYSGSEEEDDSHGEEGE-PSSIMNVPGESTLRREFLRLQQENKSNSEALK---- 370
Query: 911 QEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
Q+++L + Q ++ + + + + + + + ++ +RR+ E Q + ++++ +K+QQ
Sbjct: 371 QQQQLQQQQQ--RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428
Query: 971 LDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLK--QQLK 1028
++ + ++++ A ERE ++QL R++ E +R LQ++H LK QQ +
Sbjct: 429 RLEDMQALRREEERRQA--EREQEYKRKQLEEQRQS---ERLQRQLQQEHAYLKSLQQQQ 483
Query: 1029 DQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARLPKIQRS 1077
Q +Q+ Q + + + + Y + + K R+ +ER R+ K Q S
Sbjct: 484 QQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 21/160 (13%)
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
LQ++++ + LK Q +Q+ Q + E + + QR IEE Q +ER R+ + Q
Sbjct: 358 LQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQQ 412
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQ 1135
R E + R K+ R R + Q +EE+R++ ER Q+++ + + Q
Sbjct: 413 RREREQRKLQEKEQQR----------RLEDMQALRREEERRQAER---EQEYKRKQLEEQ 459
Query: 1136 LQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Q E R QLQ E +L + Q+ ++L ++ Q+L
Sbjct: 460 RQSE---RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/91 (25%), Positives = 47/91 (51%), Gaps = 15/91 (16%)
Query: 1111 QEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEE 1170
Q+E + +E + Q Q+ + Q Q EA+++ HLL H+ Q+ E +E
Sbjct: 359 QQENKSNSEALKQQQQLQQQQ---QRDPEAHIK----------HLL--HQRQRRIEEQKE 403
Query: 1171 HSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
+ ++E + + R ++K E+E R+L++ +
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQ 434
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 242 bits (618), Expect = 1e-63
Identities = 180/600 (30%), Positives = 295/600 (49%), Gaps = 50/600 (8%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSH 78
Query: 89 P-NIVKLLDAFYY------ENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF ++ LW+++EFC G+V D V L E I +C++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH +K+IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WSLGIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F DF+ CL K +R T QLL+ PF+ + R++ + K + K+
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTE--RQVRIQLKDHID---RSRKK 312
Query: 321 EDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKI 380
E+EETE S D S E N ++ + R E+K NS+
Sbjct: 313 RGEKEETEYEY----SGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEA 368
Query: 381 LNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQE 440
L ++ + ++ D HI LH R I+E + E+R E +Q
Sbjct: 369 LKQQQQLQQQQQ--RDPEAHIKHL-------LHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 441 TVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVD 500
+ +E LE +++ + EE + E++Q ++ K ++ + + + + +
Sbjct: 420 KL--------QEKEQQRRLE-DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQL- 469
Query: 501 LVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQK 560
Q+ ++Q + L K+ Q+ L D K + + + + A++
Sbjct: 470 ---QQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKP----LYHYGRGMNPADKPAWARE 522
Query: 561 VDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMN---EIEEGKNK 617
V+E + + Q N + G P+ P+A P+ + M E +EG +K
Sbjct: 523 VEERTRMNKQQNSPLAKSKPGSTGPEPPI--PQASPGPPGPLSQTPPMQRPVEPQEGPHK 580
Score = 60.8 bits (146), Expect = 8e-09
Identities = 53/224 (23%), Positives = 111/224 (49%), Gaps = 26/224 (11%)
Query: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
F ++ ++++ Q +++++ +K+ E+ E E+ +E GE E E S N+
Sbjct: 288 FIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNV- 345
Query: 923 KNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQ-ELDGSLKKIIQQ 981
LR+E ++ ++E + S+ ++Q+ +Q+QQQ + + +K ++ Q
Sbjct: 346 ------------PGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 982 QKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKR 1041
+ +R K++ R E E E+R LQEK Q +++L+D ++R + ++
Sbjct: 394 R-------QRRIEEQKEERRRVEEQQRREREQRKLQEKEQ--QRRLEDMQALRREEERRQ 444
Query: 1042 HEKETE--QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRM 1083
E+E E + Q QR E L+ + QE A L +Q+ + + ++
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQL 488
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/222 (24%), Positives = 96/222 (43%), Gaps = 38/222 (17%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S I+ T FLR Q+ L++ + LQ+++QR + L QR++
Sbjct: 340 SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIE 399
Query: 862 RFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNM 921
++E + Q +E E + Q+K+ RLE LR E +R + E+E+E +
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLED--MQALRREEERRQAEREQEYKR---- 453
Query: 922 LKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQ 981
K+L ++ R + Q +HA + Q+QQQ+ ++ +Q
Sbjct: 454 ----------------KQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ------QLQKQ 491
Query: 982 QKAELANIERECLNNKQQLMRAREAAIW--ELEERHLQEKHQ 1021
Q+ +L +R+ L + + M + W E+EER K Q
Sbjct: 492 QQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQ 533
Score = 50.8 bits (120), Expect = 8e-06
Identities = 59/292 (20%), Positives = 136/292 (46%), Gaps = 19/292 (6%)
Query: 793 KKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL-RELRFLQKEE-QRAQQQLNS 850
KK K +D ++ + + + + + F+R Q R++R K+ R++++
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 851 KLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGE 910
K + + E E + ++ + I N+ + E L + N+ EA +
Sbjct: 316 KEETEYEYSGSEEEDDSHGEEGE-PSSIMNVPGESTLRREFLRLQQENKSNSEALK---- 370
Query: 911 QEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
Q+++L + Q ++ + + + + + + + ++ +RR+ E Q + ++++ +K+QQ
Sbjct: 371 QQQQLQQQQQ--RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428
Query: 971 LDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLK--QQLK 1028
++ + ++++ A ERE ++QL R++ E +R LQ++H LK QQ +
Sbjct: 429 RLEDMQALRREEERRQA--EREQEYKRKQLEEQRQS---ERLQRQLQQEHAYLKSLQQQQ 483
Query: 1029 DQYFMQRHQLLKRHEKETEQMQRYNQRLIEELK---NRQTQERARLPKIQRS 1077
Q +Q+ Q + + + + Y + + K R+ +ER R+ K Q S
Sbjct: 484 QQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 21/160 (13%)
Query: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
LQ++++ + LK Q +Q+ Q + E + + QR IEE Q +ER R+ + Q
Sbjct: 358 LQQENKSNSEALKQQQQLQQQQQ-RDPEAHIKHLLHQRQRRIEE----QKEERRRVEEQQ 412
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQ 1135
R E + R K+ R R + Q +EE+R++ ER Q+++ + + Q
Sbjct: 413 RREREQRKLQEKEQQR----------RLEDMQALRREEERRQAER---EQEYKRKQLEEQ 459
Query: 1136 LQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQEL 1175
Q E R QLQ E +L + Q+ ++L ++ Q+L
Sbjct: 460 RQSE---RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/91 (25%), Positives = 47/91 (51%), Gaps = 15/91 (16%)
Query: 1111 QEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEE 1170
Q+E + +E + Q Q+ + Q Q EA+++ HLL H+ Q+ E +E
Sbjct: 359 QQENKSNSEALKQQQQLQQQQ---QRDPEAHIK----------HLL--HQRQRRIEEQKE 403
Query: 1171 HSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
+ ++E + + R ++K E+E R+L++ +
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQ 434
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 242 bits (618), Expect = 1e-63
Identities = 127/306 (41%), Positives = 182/306 (59%), Gaps = 7/306 (2%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P D +E++ +G G +G VYKA++ TS LAA K++ +++ EI IL C H
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRH 70
Query: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
PN+V + ++ + LWI +EFC GG++ + PL E QI VC++ L L++LH
Sbjct: 71 PNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY-HATGPLEERQIAYVCREALKGLHHLHS 129
Query: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
IHRD+K N+L TL GD+KLADFGVS + T ++ +R SFIGTPYWMAPEV E +
Sbjct: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--R 187
Query: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Y+ DVW+LGIT IE+ E++PP L+PMR L+ ++KS +PP L +RW+ NF
Sbjct: 188 KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH 247
Query: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEE 326
FLK L KN R T +LLQHPF T + + + + ++ + ED E E
Sbjct: 248 HFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASD--PHLGTPSPEDCELE 305
Query: 327 TENSLP 332
T + P
Sbjct: 306 TYDMFP 311
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 241 bits (616), Expect = 2e-63
Identities = 121/281 (43%), Positives = 176/281 (62%), Gaps = 10/281 (3%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDIL-ASCD 87
+P D WEI +G G +GKV+K NK+ AA K++D + + E+ E +IL A D
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDID-EEIEAEYNILKALSD 74
Query: 88 HPNIVKLLDAFYYENN-----LWILIEFCAGGAVDAVM---LELERPLTESQIQVVCKQT 139
HPN+V+ ++ ++ LW+++E C+GG+V ++ L+ ++E I + +
Sbjct: 75 HPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 140 LDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAP 199
L L +LH+NK IHRD+K NIL T +G +KL DFGVSA+ T T RR++ +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 200 EVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPS 259
EV+ CE D YD + D WSLGIT IE+ + +PP +L+PMR L KI ++ PP L QP
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 260 RWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 300
WS+ F DF+ KCL K+ + R T S+LLQH F+T K +
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDV 295
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 240 bits (612), Expect = 7e-63
Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 8/308 (2%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
NP++ +E+I +G G +G VYKA+N T LAA KVI + E+ EI ++ C H
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
PNIV ++ + LWI +EFC GG++ + + PL+E QI V ++TL L YLH
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIAYVSRETLQGLYYLHS 129
Query: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
+HRD+K NIL T +G +KLADFGVSA+ T TI +R SFIGTPYWMAPEV E +
Sbjct: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--R 187
Query: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Y+ D+W++GIT IE+AE++PP +L+PMR L + KS +PP L +WS++F
Sbjct: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247
Query: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEE 326
F+K L KN R T +LLQHPFVT R L E +V + ++++
Sbjct: 248 HFVKMALTKNPKKRPTAEKLLQHPFVT---QHLTRSLAIELLDKVNNPDHSTYHDFDDDD 304
Query: 327 TENSLPIP 334
E + +P
Sbjct: 305 PEPLVAVP 312
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 239 bits (610), Expect = 1e-62
Identities = 200/761 (26%), Positives = 348/761 (45%), Gaps = 93/761 (12%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ +EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSH 78
Query: 89 P-NIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +++ LW+++EFC G++ D V L E I + ++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH + +IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WS GIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEV--------- 311
WS F F++ CL KN R +T QLL+HPF+ N+ R++ + K +
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE--RQVRIQLKDHIDRTRKKRGE 315
Query: 312 ---TEEVEDGKEEDEEE------ETENSLPIPASKRASSDLSIASSEEDKLSQNACILES 362
TE G EE+EEE E + + +P D E + S+ +
Sbjct: 316 KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQL 375
Query: 363 VSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKEN 422
+ E+ R E K ++L E+ E +K + + + Q + +
Sbjct: 376 LQEQQLREQEEYK--RQLLAERQKRIEQQK---EQRRRLEEQQRREREARRQQEREQRRR 430
Query: 423 EREKRPKLENL-----PDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEK 477
E+E++ +LE L + E + + E ++ I LE H +++ QE+
Sbjct: 431 EQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
Query: 478 QQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKT 537
+ E + + EE + + + ++ +++A + ++ + ++ +
Sbjct: 491 AMLLECRWREMEEHRQ-----AERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQE 545
Query: 538 QKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEA--- 594
+ + + E AD A++V++ + S+ + + G+ L +P V +
Sbjct: 546 RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVL--EPPVPSRSESF 603
Query: 595 --GGTKEV------PIKEIVEMNEIEEGKNKEQAINSSENIMD----------INEEPGT 636
G ++ V P + V+ + + KN ++ S + D +++P
Sbjct: 604 SNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCP 663
Query: 637 TEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEV 696
E+ SS + +S D QKA D E+P P V
Sbjct: 664 PSRSEVLSQSS----DSKSEAPDPTQKAWSRSDSD-------------EVP------PRV 700
Query: 697 TVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILP 737
V + T PVL + SG+ + G + T +I P
Sbjct: 701 PV--RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 739
Score = 62.0 bits (149), Expect = 3e-09
Identities = 45/163 (27%), Positives = 89/163 (54%), Gaps = 13/163 (7%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL---NSKLQQQREQIFRRFEQEMMSK--KRQYD 875
E LRRQ+L + + L+++E+ +Q L +++QQ+EQ R EQ+ + +RQ +
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 876 QEIENLEKQQKQTIERL-----EQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKK 927
+E E+++K+ +E L E+E R +E +R++ EQE ++L + Q L+ ++
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 928 EVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
+++ E + +E+ + R+ E Q Q QEQ ++ Q +
Sbjct: 485 QLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHD 527
Score = 57.4 bits (137), Expect = 8e-08
Identities = 58/224 (25%), Positives = 106/224 (47%), Gaps = 38/224 (16%)
Query: 826 LRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQ 885
LRR LR LQ+E + + L + Q +Q+ +E KRQ E + +QQ
Sbjct: 352 LRRDFLR----LQQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ 402
Query: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
K+ RLE++ R EA+R +QE+E Q + +K + E+E+ RKE
Sbjct: 403 KEQRRRLEEQ--QRREREARR---QQERE----QRRREQEEKRRLEELERR----RKEEE 449
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
+RR+ E + + +EQE++++Q +++++ L ++++ L + L+ R
Sbjct: 450 ERRRAEEEKRRVEREQEYIRRQ-----------LEEEQRHLEVLQQQLLQEQAMLLECR- 497
Query: 1006 AAIW-ELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQ 1048
W E+EE E+ Q QQ + +H + H + ++Q
Sbjct: 498 ---WREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQ 538
Score = 53.1 bits (126), Expect = 2e-06
Identities = 50/242 (20%), Positives = 122/242 (50%), Gaps = 24/242 (9%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHT 897
Q E++ + QL + + R++ + E E + ++E ++ + +I + E T
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
Query: 898 NRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKEL---RKELMKRRKEELAQ 954
LR + R++ ++ KE S+ + +++ + E E+ ++L R++ ++++KE+ +
Sbjct: 352 --LRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 955 SQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEER 1014
+ Q +E ++QQE + ++ Q++K L +ER K++ R R E E+R
Sbjct: 409 LEEQQRREREARRQQEREQRRRE--QEEKRRLEELER---RRKEEEERRRA----EEEKR 459
Query: 1015 HLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKI 1074
++ + + +++QL+++ +RH + +Q Q ++ E + R+ +E + ++
Sbjct: 460 RVEREQEYIRRQLEEE---------QRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERL 510
Query: 1075 QR 1076
QR
Sbjct: 511 QR 512
Score = 50.1 bits (118), Expect = 1e-05
Identities = 75/311 (24%), Positives = 143/311 (45%), Gaps = 44/311 (14%)
Query: 941 RKELMKRRKEELAQSQHAQEQEFVQKQQQEL--------DGSLKKIIQQQKAELANIERE 992
RK+ ++ + E S +E+E V +Q+ E + +L++ + + E N ER
Sbjct: 310 RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE--NKERS 367
Query: 993 CLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRY 1052
+QQL++ ++ E +R L + Q +Q K+Q +R + +R E+E + Q
Sbjct: 368 EALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ--RRRLEEQQRREREARRQQER 425
Query: 1053 NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQE 1112
QR E+ + R+ +E R +R E + R ++ R+ +++++ I++ Q
Sbjct: 426 EQRRREQEEKRRLEELER----RRKEEEERRRAEEEKRRV------EREQEYIRR---QL 472
Query: 1113 EKRQKNERMAQHQKHENQMRDLQLQCEANVRELH--------QLQNEKCHLL-VEHETQK 1163
E+ Q++ + Q Q + Q + L+C E H QLQ E+ +LL ++H+ ++
Sbjct: 473 EEEQRHLEVLQQQLLQEQA--MLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRR 530
Query: 1164 LKELDEEHSQE-LKEWREKLRPRKKTLEE----EFARKLQEQEVFFKMTGESECLNPSTQ 1218
+HSQ+ +E+ +P E E A + +E E F+ T S S Q
Sbjct: 531 ---PHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQ 587
Query: 1219 SRISKFYPIPS 1229
+ P+PS
Sbjct: 588 TGRVLEPPVPS 598
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/188 (23%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEK-ETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Q + ++ QLKD R KR EK ETE ++ EE+ ++ + + +
Sbjct: 292 QPNERQVRIQLKDHIDRTRK---KRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQK--NERMAQHQKHENQMRD 1133
S + ++ + S A Q + +Q QEE +++ ER + ++ + Q R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
L+ Q + RE + Q + + E ++L+EL+ +E + R + R+ E+E+
Sbjct: 409 LEEQ-QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
Query: 1194 ARKLQEQE 1201
R+ E+E
Sbjct: 468 IRRQLEEE 475
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 238 bits (607), Expect = 3e-62
Identities = 122/310 (39%), Positives = 187/310 (60%), Gaps = 15/310 (4%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASC-D 87
+P D WEII +G G +GKVYK NK LAA K++D S+ + E+ E +IL +
Sbjct: 22 DPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMD-EEIEAEYNILQFLPN 80
Query: 88 HPNIVKLLDAFYYENN-----LWILIEFCAGGAVDAV---MLELERPLTESQIQVVCKQT 139
HPN+VK FY ++ LW+++E C GG+V + +L + L E+ I +
Sbjct: 81 HPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGA 140
Query: 140 LDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAP 199
L L +LH+N+IIHRD+K NIL T +G +KL DFGVSA+ T T RR++ +GTP+WMAP
Sbjct: 141 LLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAP 200
Query: 200 EVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPS 259
EV+ CE D YD + DVWSLGIT IE+ + +PP +++P++ L KI ++ PPTL P
Sbjct: 201 EVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPE 260
Query: 260 RWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGK 319
+W F F+ +CL K+ + R + + LL HPF+ K + + + ++ + ++D K
Sbjct: 261 KWCEEFNHFISQCLIKDFERRPSVTHLLDHPFI-----KGVHGKVLFLQKQLAKVLQDQK 315
Query: 320 EEDEEEETEN 329
++ +T +
Sbjct: 316 HQNPVAKTRH 325
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 238 bits (607), Expect = 3e-62
Identities = 122/310 (39%), Positives = 187/310 (60%), Gaps = 15/310 (4%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASC-D 87
+P D WEII +G G +GKVYK NK LAA K++D S+ + E+ E +IL +
Sbjct: 22 DPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMD-EEIEAEYNILQFLPN 80
Query: 88 HPNIVKLLDAFYYENN-----LWILIEFCAGGAVDAV---MLELERPLTESQIQVVCKQT 139
HPN+VK FY ++ LW+++E C GG+V + +L + L E+ I +
Sbjct: 81 HPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGA 140
Query: 140 LDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAP 199
L L +LH+N+IIHRD+K NIL T +G +KL DFGVSA+ T T RR++ +GTP+WMAP
Sbjct: 141 LLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAP 200
Query: 200 EVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPS 259
EV+ CE D YD + DVWSLGIT IE+ + +PP +++P++ L KI ++ PPTL P
Sbjct: 201 EVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPE 260
Query: 260 RWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGK 319
+W F F+ +CL K+ + R + + LL HPF+ K + + + ++ + ++D K
Sbjct: 261 KWCEEFNHFISQCLIKDFERRPSVTHLLDHPFI-----KGVHGKVLFLQKQLAKVLQDQK 315
Query: 320 EEDEEEETEN 329
++ +T +
Sbjct: 316 HQNPVAKTRH 325
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 238 bits (606), Expect = 3e-62
Identities = 206/754 (27%), Positives = 353/754 (46%), Gaps = 67/754 (8%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ +EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSH 78
Query: 89 P-NIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +++ LW+++EFC G++ D V L E I + ++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH + +IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WS GIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F F++ CL KN R +T QLL+HPF+ N+ R++ + K + + E
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE--RQVRIQLKDHIDRTRKKRGE 315
Query: 321 EDEEE-----ETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDK 375
+DE E E +P + S + E + L E ER SE
Sbjct: 316 KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES---TLRRDFLRLQQENKER--SEAL 370
Query: 376 LNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPD 435
++L E+ ++ E + + E ++E E R + ERE R + E
Sbjct: 371 RRQQLLQEQQLREQEEYKRQLLAER--QKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428
Query: 436 TEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQ-EKQQMFENKLIKSEEIKDT 494
+QE E + + E ++EEEK + E++Q + + ++ E+
Sbjct: 429 RREQE--------EKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ---- 476
Query: 495 ILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEA 554
+ ++++ Q+ +++A + D + Q + ++++ + + E
Sbjct: 477 --RHLEVLQQQLLQEQAML-LHDHRRPHPQHSQQPPPPQQERSKPSF--HAPEPKAHYEP 531
Query: 555 ADVAQKVD--EDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIE 612
AD A++V S S + GQ+ +AG E + E
Sbjct: 532 ADRAREVPVRTTSRSPVLSRRDSPLQGSGQQ-------NSQAGQRNSTSSIEPRLLWERV 584
Query: 613 EGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDA 672
E SS + +PG+ G ++S S E VRS K+ GS Q
Sbjct: 585 EKLVPRPGSGSSSGSSNSGSQPGSHPG---SQSGSGERFRVRS-----SSKSEGSPSQRL 636
Query: 673 SKVTTQIDKEKKEI--PVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLS 730
+ ++KKE+ P+ E ++T +++ + P + +D + EE G+
Sbjct: 637 ENAVKK-PEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKV-TDYSSSSEESGTTD 694
Query: 731 KTETILPPESENPKENDNDSGTGSTADTSSIDLN 764
+ + + E +++ SG T SS++L+
Sbjct: 695 EED----DDVEQEGADESTSGPEDTRAASSLNLS 724
Score = 53.9 bits (128), Expect = 9e-07
Identities = 47/162 (29%), Positives = 78/162 (48%), Gaps = 22/162 (13%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S IV T FLR Q+ LR + LQ+++ R Q++ +L +R+ +
Sbjct: 341 SSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ---K 397
Query: 862 RFEQEMMSKKRQYDQEIENLE--KQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQ 919
R EQ+ ++R +Q+ E +QQ++ R EQE RL + +R K E+E+ ++
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE-- 455
Query: 920 NMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQ 961
K+ V E E ++L +E +R E+ Q Q QEQ
Sbjct: 456 ----EEKRRVEREQEYIRRQLEEE---QRHLEVLQQQLLQEQ 490
Score = 53.9 bits (128), Expect = 9e-07
Identities = 37/154 (24%), Positives = 81/154 (52%), Gaps = 5/154 (3%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL---NSKLQQQREQIFRRFEQEMMSKKRQYDQE 877
E LRRQ+L + + L+++E+ +Q L +++QQ+EQ R EQ+ ++ + QE
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 878 IENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAP 937
E ++Q++ RLE+ R +E +R E+++ + + Q ++ + +E +E
Sbjct: 425 REQRRREQEEK-RRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ 483
Query: 938 KE-LRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
++ L+++ M QH+Q+ Q+++ +
Sbjct: 484 QQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 51.2 bits (121), Expect = 6e-06
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 22/162 (13%)
Query: 826 LRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQ 885
LRR LR LQ+E + + L + Q +Q+ +E KRQ E + +QQ
Sbjct: 352 LRRDFLR----LQQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ 402
Query: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
K+ RLE++ R EA+R +QE+E Q + +K + E+E+ RKE
Sbjct: 403 KEQRRRLEEQ--QRREREARR---QQERE----QRRREQEEKRRLEELERR----RKEEE 449
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELA 987
+RR+ E + + +EQE++++Q +E L+ + QQ E A
Sbjct: 450 ERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Score = 48.5 bits (114), Expect = 4e-05
Identities = 52/275 (18%), Positives = 121/275 (44%), Gaps = 49/275 (17%)
Query: 857 EQIFRR-FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKEL 915
EQ+ + F ++ ++++ Q +++++ +K+ E+ E E+ +E + EQE E
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEP 340
Query: 916 SKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSL 975
S N+ LR++ ++ ++E +S+ + Q+ +Q+QQ
Sbjct: 341 SSIVNV-------------PGESTLRRDFLRLQQENKERSEALRRQQLLQEQQL------ 381
Query: 976 KKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQR 1035
RE K+QL+ R+ I E+ +++ +L +QQ +++
Sbjct: 382 ---------------REQEEYKRQLLAERQKRI----EQQKEQRRRLEEQQRRER----- 417
Query: 1036 HQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINST 1095
+ ++ E+E + ++ +R +EEL+ R+ +E R +R+E + R ++
Sbjct: 418 -EARRQQEREQRRREQEEKRRLEELERRRKEEEER----RRAEEEKRRVEREQEYIRRQL 472
Query: 1096 ATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQ 1130
+ + ++Q QE+ ++ H +H Q
Sbjct: 473 EEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/221 (20%), Positives = 110/221 (49%), Gaps = 15/221 (6%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHT 897
Q E++ + QL + + R++ + E E + ++E ++ + +I + E T
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
Query: 898 NRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKEL---RKELMKRRKEELAQ 954
LR + R++ ++ KE S+ + +++ + E E+ ++L R++ ++++KE+ +
Sbjct: 352 --LRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 955 SQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEER 1014
+ Q +E ++QQE + ++ Q++K L +ER +++ E E E+
Sbjct: 409 LEEQQRREREARRQQEREQRRRE--QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQE 466
Query: 1015 HL------QEKH-QLLKQQLKDQYFMQRHQLLKRHEKETEQ 1048
++ +++H ++L+QQL + M H + H + ++Q
Sbjct: 467 YIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/188 (23%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEK-ETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Q + ++ QLKD R KR EK ETE ++ EE+ ++ + + +
Sbjct: 292 QPNERQVRIQLKDHIDRTRK---KRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQK--NERMAQHQKHENQMRD 1133
S + ++ + S A Q + +Q QEE +++ ER + ++ + Q R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
L+ Q + RE + Q + + E ++L+EL+ +E + R + R+ E+E+
Sbjct: 409 LEEQ-QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
Query: 1194 ARKLQEQE 1201
R+ E+E
Sbjct: 468 IRRQLEEE 475
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 237 bits (604), Expect = 6e-62
Identities = 126/304 (41%), Positives = 190/304 (62%), Gaps = 13/304 (4%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK-SEEELEDYMVEIDILASCD 87
+PE+ + + ++G G+FG+V+K + T + A K+ID + +E+E+ED EI +L+ CD
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 88 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 147
P + K ++ + LWI++E+ GG+ A+ L PL E+QI + ++ L L+YLH
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGS--ALDLLEPGPLDETQIATILREILKGLDYLH 136
Query: 148 DNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETS 207
K IHRD+KA N+L + G++KLADFGV+ + T T +R++F+GTP+WMAPEV+
Sbjct: 137 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 191
Query: 208 KDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKD 267
K YD KAD+WSLGIT IE+A EPPH EL+PM+VL I K+ PPTL +S K+
Sbjct: 192 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL--EGNYSKPLKE 249
Query: 268 FLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP--IRELIAEAKAEVTEEV-EDGKEEDEE 324
F++ CL K R T +LL+H F+ ++ K + ELI K E+ +D ED +
Sbjct: 250 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 309
Query: 325 EETE 328
ET+
Sbjct: 310 AETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 237 bits (604), Expect = 6e-62
Identities = 126/304 (41%), Positives = 190/304 (62%), Gaps = 13/304 (4%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK-SEEELEDYMVEIDILASCD 87
+PE+ + + ++G G+FG+V+K + T + A K+ID + +E+E+ED EI +L+ CD
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 88 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 147
P + K ++ + LWI++E+ GG+ A+ L PL E+QI + ++ L L+YLH
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGS--ALDLLEPGPLDETQIATILREILKGLDYLH 148
Query: 148 DNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETS 207
K IHRD+KA N+L + G++KLADFGV+ + T T +R++F+GTP+WMAPEV+
Sbjct: 149 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 203
Query: 208 KDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKD 267
K YD KAD+WSLGIT IE+A EPPH EL+PM+VL I K+ PPTL +S K+
Sbjct: 204 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL--EGNYSKPLKE 261
Query: 268 FLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP--IRELIAEAKAEVTEEV-EDGKEEDEE 324
F++ CL K R T +LL+H F+ ++ K + ELI K E+ +D ED +
Sbjct: 262 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 321
Query: 325 EETE 328
ET+
Sbjct: 322 AETD 325
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 236 bits (602), Expect = 1e-61
Identities = 157/483 (32%), Positives = 251/483 (51%), Gaps = 33/483 (6%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
+P +E++ +G+G +G+VYK ++ +T LAA KV+D +EE E+ +EI++L H
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSH 78
Query: 89 P-NIVKLLDAFY------YENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTL 140
NI AF +++ LW+++EFC G++ D V L E I + ++ L
Sbjct: 79 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 138
Query: 141 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 200
L +LH + +IHRD+K N+L T + ++KL DFGVSA+ RT+ RR++FIGTPYWMAPE
Sbjct: 139 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 201 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
V+ C+ + D YDY++D+WS GIT IEMAE PP +++PMR L I ++ PP L + +
Sbjct: 199 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKK 257
Query: 261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKE 320
WS F F++ CL KN R +T QLL+HPF+ N+ R++ + K + + E
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE--RQVRIQLKDHIDRTRKKRGE 315
Query: 321 EDEEE-----ETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDK 375
+DE E E +P + S + E + L E ER SE
Sbjct: 316 KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES---TLRRDFLRLQQENKER--SEAL 370
Query: 376 LNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPD 435
++L E+ ++ E + + E ++E E R + ERE R + E
Sbjct: 371 RRQQLLQEQQLREQEEYKRQLLAER--QKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428
Query: 436 TEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQ-EKQQMFENKLIKSEEIKDT 494
+QE E + + E ++EEEK + E++Q + + ++ E+
Sbjct: 429 RREQE--------EKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 495 ILQ 497
+LQ
Sbjct: 481 VLQ 483
Score = 53.9 bits (128), Expect = 9e-07
Identities = 47/162 (29%), Positives = 78/162 (48%), Gaps = 22/162 (13%)
Query: 810 SKIVTDSDSKTEELRFLRRQE--------LRELRFLQKEEQRAQQQLNSKLQQQREQIFR 861
S IV T FLR Q+ LR + LQ+++ R Q++ +L +R+ +
Sbjct: 341 SSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ---K 397
Query: 862 RFEQEMMSKKRQYDQEIENLE--KQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQ 919
R EQ+ ++R +Q+ E +QQ++ R EQE RL + +R K E+E+ ++
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE-- 455
Query: 920 NMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQ 961
K+ V E E ++L +E +R E+ Q Q QEQ
Sbjct: 456 ----EEKRRVEREQEYIRRQLEEE---QRHLEVLQQQLLQEQ 490
Score = 53.9 bits (128), Expect = 9e-07
Identities = 37/154 (24%), Positives = 81/154 (52%), Gaps = 5/154 (3%)
Query: 821 EELRFLRRQELRELRFLQKEEQRAQQQL---NSKLQQQREQIFRRFEQEMMSKKRQYDQE 877
E LRRQ+L + + L+++E+ +Q L +++QQ+EQ R EQ+ ++ + QE
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 878 IENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAP 937
E ++Q++ RLE+ R +E +R E+++ + + Q ++ + +E +E
Sbjct: 425 REQRRREQEEK-RRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ 483
Query: 938 KE-LRKELMKRRKEELAQSQHAQEQEFVQKQQQE 970
++ L+++ M QH+Q+ Q+++ +
Sbjct: 484 QQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 51.2 bits (121), Expect = 6e-06
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 22/162 (13%)
Query: 826 LRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQ 885
LRR LR LQ+E + + L + Q +Q+ +E KRQ E + +QQ
Sbjct: 352 LRRDFLR----LQQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ 402
Query: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
K+ RLE++ R EA+R +QE+E Q + +K + E+E+ RKE
Sbjct: 403 KEQRRRLEEQ--QRREREARR---QQERE----QRRREQEEKRRLEELERR----RKEEE 449
Query: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELA 987
+RR+ E + + +EQE++++Q +E L+ + QQ E A
Sbjct: 450 ERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Score = 48.5 bits (114), Expect = 4e-05
Identities = 52/275 (18%), Positives = 121/275 (44%), Gaps = 49/275 (17%)
Query: 857 EQIFRR-FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKEL 915
EQ+ + F ++ ++++ Q +++++ +K+ E+ E E+ +E + EQE E
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEP 340
Query: 916 SKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSL 975
S N+ LR++ ++ ++E +S+ + Q+ +Q+QQ
Sbjct: 341 SSIVNV-------------PGESTLRRDFLRLQQENKERSEALRRQQLLQEQQL------ 381
Query: 976 KKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQR 1035
RE K+QL+ R+ I E+ +++ +L +QQ +++
Sbjct: 382 ---------------REQEEYKRQLLAERQKRI----EQQKEQRRRLEEQQRRER----- 417
Query: 1036 HQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINST 1095
+ ++ E+E + ++ +R +EEL+ R+ +E R +R+E + R ++
Sbjct: 418 -EARRQQEREQRRREQEEKRRLEELERRRKEEEER----RRAEEEKRRVEREQEYIRRQL 472
Query: 1096 ATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQ 1130
+ + ++Q QE+ ++ H +H Q
Sbjct: 473 EEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/221 (20%), Positives = 110/221 (49%), Gaps = 15/221 (6%)
Query: 838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHT 897
Q E++ + QL + + R++ + E E + ++E ++ + +I + E T
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
Query: 898 NRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKEL---RKELMKRRKEELAQ 954
LR + R++ ++ KE S+ + +++ + E E+ ++L R++ ++++KE+ +
Sbjct: 352 --LRRDFLRLQ-QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 955 SQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEER 1014
+ Q +E ++QQE + ++ Q++K L +ER +++ E E E+
Sbjct: 409 LEEQQRREREARRQQEREQRRRE--QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQE 466
Query: 1015 HL------QEKH-QLLKQQLKDQYFMQRHQLLKRHEKETEQ 1048
++ +++H ++L+QQL + M H + H + ++Q
Sbjct: 467 YIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/188 (23%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 1017 QEKHQLLKQQLKDQYFMQRHQLLKRHEK-ETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Q + ++ QLKD R KR EK ETE ++ EE+ ++ + + +
Sbjct: 292 QPNERQVRIQLKDHIDRTRK---KRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQK--NERMAQHQKHENQMRD 1133
S + ++ + S A Q + +Q QEE +++ ER + ++ + Q R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 1134 LQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEF 1193
L+ Q + RE + Q + + E ++L+EL+ +E + R + R+ E+E+
Sbjct: 409 LEEQ-QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
Query: 1194 ARKLQEQE 1201
R+ E+E
Sbjct: 468 IRRQLEEE 475
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 233 bits (594), Expect = 8e-61
Identities = 126/305 (41%), Positives = 191/305 (62%), Gaps = 13/305 (4%)
Query: 28 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK-SEEELEDYMVEIDILASC 86
++PE+ + + +G G+FG+VYK + T + A K+ID + +E+E+ED EI +L+ C
Sbjct: 14 VDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC 73
Query: 87 DHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYL 146
D P I + ++ LWI++E+ GG+ A+ L PL E+ I + ++ L L+YL
Sbjct: 74 DSPYITRYFGSYLKSTKLWIIMEYLGGGS--ALDLLKPGPLEETYIATILREILKGLDYL 131
Query: 147 HDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCET 206
H + IHRD+KA N+L + GD+KLADFGV+ + T T +R++F+GTP+WMAPEV+
Sbjct: 132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---- 187
Query: 207 SKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFK 266
K YD+KAD+WSLGIT IE+A+ EPP+ +L+PMRVL I K+ PPTL + S FK
Sbjct: 188 -KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTL--EGQHSKPFK 244
Query: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP--IRELIAEAKAEVTE-EVEDGKEEDE 323
+F++ CL K+ R T +LL+H F+T + K + ELI K +E E+ ED
Sbjct: 245 EFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDS 304
Query: 324 EEETE 328
+ + E
Sbjct: 305 DIDGE 309
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 233 bits (593), Expect = 1e-60
Identities = 119/266 (44%), Positives = 166/266 (62%), Gaps = 5/266 (1%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
NP+ +E++ +G G +G VYKA+N T LAA K+I + ++ EI ++ C H
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
Query: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
NIV ++ LWI +E+C GG++ + + PL+E QI VC++TL L YLH
Sbjct: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
+HRD+K NIL T GD+KLADFGV+AK T TI +R SFIGTPYWMAPEV E K
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
Query: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
+ Y+ D+W++GIT IE+ E++PP +L+PMR L ++KS +PP L ++WSS F
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
Query: 267 DFLKKCLEKNVDARWTTSQLLQHPFV 292
+F+K L KN R T +LL H FV
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 233 bits (593), Expect = 1e-60
Identities = 119/266 (44%), Positives = 166/266 (62%), Gaps = 5/266 (1%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
NP+ +E++ +G G +G VYKA+N T LAA K+I + ++ EI ++ C H
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
Query: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
NIV ++ LWI +E+C GG++ + + PL+E QI VC++TL L YLH
Sbjct: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
+HRD+K NIL T GD+KLADFGV+AK T TI +R SFIGTPYWMAPEV E K
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
Query: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
+ Y+ D+W++GIT IE+ E++PP +L+PMR L ++KS +PP L ++WSS F
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
Query: 267 DFLKKCLEKNVDARWTTSQLLQHPFV 292
+F+K L KN R T +LL H FV
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 230 bits (587), Expect = 5e-60
Identities = 132/380 (34%), Positives = 215/380 (56%), Gaps = 12/380 (3%)
Query: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK-SEEELEDYMVEIDILASCD 87
+PE+ + + +G G+FG+V+K + T + A K+ID + +E+E+ED EI +L+ CD
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 88 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 147
+ K ++ + LWI++E+ GG+ A+ L P E QI + K+ L L+YLH
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGS--ALDLLRAGPFDEFQIATMLKEILKGLDYLH 136
Query: 148 DNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETS 207
K IHRD+KA N+L + GD+KLADFGV+ + T T +R++F+GTP+WMAPEV+
Sbjct: 137 SEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----- 191
Query: 208 KDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKD 267
+ YD KAD+WSLGIT IE+A+ EPP+ +++PMRVL I K+ PPTL ++ +FK+
Sbjct: 192 QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV--GDFTKSFKE 249
Query: 268 FLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP--IRELIAEAKAEVTEEVEDGKEEDEEE 325
F+ CL K+ R T +LL+H F+ +S K + ELI K E D + + E
Sbjct: 250 FIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGS 309
Query: 326 ETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKP 385
++E++ + S ++ + K QN + V + S +++ +
Sbjct: 310 DSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDE 369
Query: 386 TTDEPEKAVEDINEHITDAQ 405
+A+E++ + I A+
Sbjct: 370 NNASRNQAIEELEKSIAVAE 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,184,011
Number of Sequences: 37866
Number of extensions: 2191324
Number of successful extensions: 40639
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1054
Number of HSP's successfully gapped in prelim test: 1869
Number of HSP's that attempted gapping in prelim test: 13800
Number of HSP's gapped (non-prelim): 13344
length of query: 1235
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1121
effective length of database: 13,930,794
effective search space: 15616420074
effective search space used: 15616420074
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.