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Search of human proteins with 41055989
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
(860 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens] 1695 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 87 7e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 82 3e-15
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 80 6e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 79 2e-14
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 78 4e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 78 4e-14
gi|221307494 chromodomain protein, Y chromosome-like isoform a [... 77 7e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 77 9e-14
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 77 9e-14
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 77 9e-14
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 77 9e-14
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 77 9e-14
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 77 9e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 76 2e-13
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 76 2e-13
gi|16975496 cortactin binding protein 2 [Homo sapiens] 75 2e-13
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 75 2e-13
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 75 3e-13
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 74 4e-13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 74 4e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 74 4e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 74 4e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 74 6e-13
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 73 1e-12
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 73 1e-12
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 73 1e-12
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 72 2e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 72 2e-12
gi|148746195 trichohyalin [Homo sapiens] 72 2e-12
>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
Length = 860
Score = 1695 bits (4390), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFE 60
MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFE
Sbjct: 1 MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFE 60
Query: 61 VEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRK 120
VEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRK
Sbjct: 61 VEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRK 120
Query: 121 DIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKD 180
DIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKD
Sbjct: 121 DIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKD 180
Query: 181 KSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT 240
KSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT
Sbjct: 181 KSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT 240
Query: 241 KTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERA 300
KTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERA
Sbjct: 241 KTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERA 300
Query: 301 GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVP 360
GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVP
Sbjct: 301 GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVP 360
Query: 361 KKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQ 420
KKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQ
Sbjct: 361 KKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQ 420
Query: 421 KRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD 480
KRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD
Sbjct: 421 KRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD 480
Query: 481 HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQL 540
HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQL
Sbjct: 481 HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQL 540
Query: 541 EWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSS 600
EWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSS
Sbjct: 541 EWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSS 600
Query: 601 GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV 660
GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV
Sbjct: 601 GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV 660
Query: 661 NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLK 720
NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLK
Sbjct: 661 NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLK 720
Query: 721 NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGI 780
NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGI
Sbjct: 721 NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGI 780
Query: 781 LLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRL 840
LLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRL
Sbjct: 781 LLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRL 840
Query: 841 TEAPSAKVKLLIGAYRVQLQ 860
TEAPSAKVKLLIGAYRVQLQ
Sbjct: 841 TEAPSAKVKLLIGAYRVQLQ 860
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 87.0 bits (214), Expect = 7e-17
Identities = 130/551 (23%), Positives = 226/551 (41%), Gaps = 111/551 (20%)
Query: 15 VSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKV 74
V + TEE EE V E+ + A+ E G EE GE+ + EGG+
Sbjct: 455 VIVEEQTEETQVTEE----VTEEEEKEAKEEE--GKEEEGGEEE---------EAEGGEE 499
Query: 75 LYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEA 134
K ++ PE ++ K + E K AE AK+ K+ EA
Sbjct: 500 ETKS-----PPAEEAASPE---KEAKSPVKEEAKSPAE--AKSPEKE-----------EA 538
Query: 135 NSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLV 194
S ++ +S K + K++ K E KSP+ + K K +K+K + +S
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKS--PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 195 FDLRTKKRISEAKEELK---ESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPK--EN 249
+K S KEE K E+K P K+E K E+K +K K+ T+E+ K E
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA-----KSPTKEEAKSPEK 651
Query: 250 RKTKKEKFVESQVESESSVLNDSPFPE----------DDSEGLHSDSREEKQNTKSARER 299
K+ +++ +S +++S V ++ PE E S +EE ++ + A+
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 300 AGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTV 359
++ + P+ E + + K+P KA+ + + L+ K+ E KT
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP--EAKTP 769
Query: 360 PKKQRNQ------DRSKSAAELEKLMPVSAQTP--------------------------- 386
K++ +++KS + E P A++P
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 387 ------KGRRLSGEERGLWSTDSAEEDKETKRNES-KEKYQKRHDSDKEEKGRKEPKGLK 439
K EE +T EE K++K+ E+ K++ K +K+E ++PK K
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 440 TLKEIRNAFDLFKL-TPEE----KNDVSENNRKREEIPLDFKTIDDHKTK------ENKQ 488
+ A D K+ TPE+ K +V E+ + +E+ + K DD K K E K+
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949
Query: 489 SLKERRNTRDE 499
+ E+++T++E
Sbjct: 950 AAPEKKDTKEE 960
Score = 81.3 bits (199), Expect = 4e-15
Identities = 79/320 (24%), Positives = 140/320 (43%), Gaps = 27/320 (8%)
Query: 133 EANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLES 192
EA S +S KE+ +K K + E K+P+ K + K +K+K S ++
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK----SPEKA 756
Query: 193 LVFDLRTKKRISEAKEELK--------ESKKPKKDEVKETKELKKVKKGEIRDLKTKTRE 244
D+++ + + AKEE + ++K P K+EVK ++ K K D K +E
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK---EDAKAPEKE 813
Query: 245 DPKENRKT----KKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERA 300
PK+ ++EK E +V+ + P DS++E+ K A +
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 301 GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVP 360
++ E EKP +S + A+++ + ++K TP K + K + K EK V
Sbjct: 874 VEEKK-EPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPK--EKTEVA 929
Query: 361 KKQRNQDRSKSA---AELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKE 417
KK+ + ++K AE ++ P T + + EE+ + E+DK + SK
Sbjct: 930 KKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989
Query: 418 KYQK-RHDSDKEEKGRKEPK 436
K +K S ++K K P+
Sbjct: 990 KAEKAEKSSSTDQKDSKPPE 1009
Score = 77.8 bits (190), Expect = 4e-14
Identities = 83/416 (19%), Positives = 181/416 (43%), Gaps = 30/416 (7%)
Query: 111 AENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSP---DD 167
+E + V + + + ++ E ++ E KE+ ++++ + + E KSP +
Sbjct: 450 SEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA 509
Query: 168 LKKKKAKAGKLKDKSKPDLES------SLESLVFDLRTKKRISEAKEELK---ESKKPKK 218
+K +K+++K E+ +S +K S AKEE K E+K P+K
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 219 DEVKETKELK---KVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFP 275
+E K E+K K K + K+ E K+ ++ +S E++S V ++ P
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 276 ED--DSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKK 333
+ E S ++EE ++ + A+ ++ + P+ + + E + + K
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 334 TPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSG 393
+P KA + K E K+ K V ++ ++ +++KS + E P A++P
Sbjct: 690 SPEKA---KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 394 EERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEP--KGLKTLKEIRNAFDLF 451
E+ + D ++ ++ K + R +DK + K P + +K+ ++ ++
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED 806
Query: 452 KLTPEE---KNDVSENNRKREEIPLDFKTIDDHKTKENKQS-----LKERRNTRDE 499
PE+ K + ++ K EE P + K + K E +++ +E+++++ E
Sbjct: 807 AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Score = 73.2 bits (178), Expect = 1e-12
Identities = 79/368 (21%), Positives = 152/368 (41%), Gaps = 44/368 (11%)
Query: 111 AENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKK 170
+E K K V K + + + E +++ +E +E K+ ++ E K + ++
Sbjct: 440 SEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE--------KEAKEEEGKEEEGGEE 491
Query: 171 KKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELK---ESKKPKKDEVKETKEL 227
++A+ G+ + KS P E++ K+ S KEE K E+K P+K+E K E+
Sbjct: 492 EEAEGGEEETKSPPAEEAASPE-------KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 228 KKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSR 287
K +K K+ +E+ K + K + E++ SP E S ++
Sbjct: 545 KSPEKA-----KSPAKEEAKSPPEAKSPEKEEAK----------SPAEVKSPEKAKSPAK 589
Query: 288 EEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEED----TDVRGRRKKKTPRK-----A 338
EE ++ A+ ++ + P ++ +E+ +V+ K K+P K
Sbjct: 590 EEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649
Query: 339 EDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGL 398
E + K E K+ K V + ++ +++KS + E P A++P E+
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKA- 708
Query: 399 WSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEK 458
+ EE K ++ +S K + + + ++E K + K A L +PE K
Sbjct: 709 -KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
Query: 459 NDVSENNR 466
E R
Sbjct: 768 TPAKEEAR 775
Score = 57.4 bits (137), Expect = 6e-08
Identities = 55/237 (23%), Positives = 107/237 (45%), Gaps = 17/237 (7%)
Query: 133 EANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKA--KAGKLKDKSKPDLESSL 190
+A S + ++ E PKK++ K +EE+ P ++K K+ KA + K + P E
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 191 ESLVFDLRTKKRISEAKEELKESKKPKKDEVKETK-ELKKVKKGEIRDLKTKTREDPKEN 249
+S + K+ K +++E K+P ++ KE+K E KK + + + + T +E P +
Sbjct: 858 DSKKEEAPKKEA---PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK- 913
Query: 250 RKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHG 309
+ K++ + + E +D+ E ++ EK++TK + + +
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE------- 966
Query: 310 FEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQ 366
EKP A + E+D + K KAE + + ++K EK T K + +
Sbjct: 967 -EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP--EKATEDKAAKGK 1020
Score = 54.7 bits (130), Expect = 4e-07
Identities = 74/364 (20%), Positives = 162/364 (44%), Gaps = 35/364 (9%)
Query: 165 PDDLKKKKAKAGKLKDKSKPDLE----SSLESLVFDLRTKKRISEAKEELKESKKPKKDE 220
P+ L K + + +K KS+ ++ S E+++ + +T++ ++ EE+ E ++ + E
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEE--TQVTEEVTEEEEKEAKE 480
Query: 221 VKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDS- 279
+E KE + ++ E + +T+ P E + EK +S V+ E+ ++ PE +
Sbjct: 481 -EEGKEEEGGEEEEAEGGEEETKSPPAEEAASP-EKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 280 ---------EGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRR 330
E S ++EE ++ A+ ++ + P + A+E + +
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPA 596
Query: 331 KKKTPRKAED-TRENRK--LENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPK 387
+ K+P KA+ +E K E K+ E+ P + ++ +++KS + E P A++P+
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 388 GRRLSGEERGLWSTDSAEEDKETKRN--ESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIR 445
E+ + + E ++ +++ K ++ S +E+ + K +KE
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716
Query: 446 NAFDLFK-------LTPEE-KNDVSENNRKREEI--PLDFKTIDDHKTKENKQSLKERRN 495
+ + K TPE+ K+ V E + E+ P KT+D + + +E R+
Sbjct: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776
Query: 496 TRDE 499
D+
Sbjct: 777 PADK 780
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/247 (23%), Positives = 103/247 (41%), Gaps = 45/247 (18%)
Query: 105 EFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKK-------KL 157
E K + AKA K+I + ++ + ++ E K PKK ++ K
Sbjct: 797 EKAKSPLKEDAKAPEKEIPK---KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT 853
Query: 158 RQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELK--ESKK 215
++++ ++ KK+A K+++K +P +E ES V KK +E K+++ E +
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV---EAKKEEAEDKKKVPTPEKEA 910
Query: 216 PKKDEVKET---KELKKVKKGEIRDLKTKTREDP----------KENRKTKKEKFVESQV 262
P K EVKE KE +V K E D K K P K+ ++ K +K E
Sbjct: 911 PAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK-- 968
Query: 263 ESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEE 322
P+ +++ D K+ +K E+A + + KP + A E
Sbjct: 969 ------------PKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE---KATE 1013
Query: 323 DTDVRGR 329
D +G+
Sbjct: 1014 DKAAKGK 1020
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 81.6 bits (200), Expect = 3e-15
Identities = 90/415 (21%), Positives = 183/415 (44%), Gaps = 46/415 (11%)
Query: 142 SETKEDTSPKKKKKKLRQREEKSPDD----LKKKKAKAGKLKDKSKPDLESSLESLVFDL 197
SE ED S K K++ +S D+ L+ +K + K+K P++ES E
Sbjct: 164 SEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASF 223
Query: 198 RTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKF 257
+ K +++ K E KE ++ K+DE E +L+K+K+ E + K + KE+++ +E+
Sbjct: 224 KIKT-VAQKKAEKKERERKKRDE--EKAKLRKLKEKEELETGKKDQSKQKESQRKFEEET 280
Query: 258 VESQVESESSVLNDS-------PFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGF 310
V+S+V ++ V+ S EDD+EG ++K+ + + + G
Sbjct: 281 VKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340
Query: 311 EKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSK 370
K + A++ ++ + R +R+++ K + E ++ E + EK+ KKQ+ ++R +
Sbjct: 341 VKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE-RKKQKEKERKE 399
Query: 371 SAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEK 430
+ KL+ S + + R + L E SK+ K+ +++K
Sbjct: 400 RLKKEGKLLTKSQREARAR--AEATLKLLQAQGVEV-------PSKDSLPKKRPIYEDKK 450
Query: 431 GRKEPKGLKTLK-----EIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD----- 480
+K P+ L++ + E+ A ++ + EK + EE + +DD
Sbjct: 451 RKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMA 510
Query: 481 -----HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQ 530
K + NK ++ + N +E + E ++E D + +E +G +
Sbjct: 511 SDEETEKVEGNKVHIEVKENPEEEEE-------EEEEEEEDEESEEEEEEEGESE 558
Score = 75.5 bits (184), Expect = 2e-13
Identities = 96/408 (23%), Positives = 176/408 (43%), Gaps = 33/408 (8%)
Query: 108 KKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDD 167
KK + + DI +L +I A + +Q+ + K KK+KKK E+ +
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQ-KSKGKKKKEKKKQDFDEDDILKE 61
Query: 168 LKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKEL 227
L++ +A +K + E+ + +K + + ++ K+S E E K+
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 228 KKVKKGEIR-DLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDS 286
K K + + ++ + + +D N+ KK K + + + + S ED+S+ + S
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAK---GKAQKSNKKWDGSEEDEDNSKKIKERS 178
Query: 287 R------EEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAE- 339
R ++ + + R GQ ++ KP + S ED D + K +KAE
Sbjct: 179 RINSSGESGDESDEFLQSRKGQKKNQKN---KPGPNIESGNEDDDASFKIKTVAQKKAEK 235
Query: 340 DTRENRKLENKNAFLEK-------KTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLS 392
RE +K + + A L K +T K Q Q S+ E E+ + G +
Sbjct: 236 KERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE-EETVKSKVTVDTGVIPA 294
Query: 393 GEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFK 452
EE+ T +A ED + K+K +K+ + +++EK +K+ T+K ++ A L K
Sbjct: 295 SEEKA--ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA--LAK 350
Query: 453 LTPEE---KNDVSENNRKREEIPLDFK---TIDDHKTKENKQSLKERR 494
L EE K + E ++ EE+ K ++ K + KQ KER+
Sbjct: 351 LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398
Score = 67.8 bits (164), Expect = 4e-11
Identities = 89/456 (19%), Positives = 190/456 (41%), Gaps = 38/456 (8%)
Query: 2 EQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEV 61
+++ E +R+ + S +S E L + G+ + + ED + F++
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRK------GQKKNQKNKPGPNIESGNEDDDASFKI 225
Query: 62 EKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKD 121
+ + K E K R + ++ ++ ++ E + + K E++ K +
Sbjct: 226 KTVAQKKAEK-----KERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEET 280
Query: 122 IQ-RLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKD 180
++ +++++ + A+ + + ED + KKKK ++++K + K+K+ K G K
Sbjct: 281 VKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK-DKKKKKGEKEEKEKEKKKGPSKA 339
Query: 181 KSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT 240
K E+ + + R K+ E + L+E + +K+E + +E ++ KK + ++ K
Sbjct: 340 TVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKE 399
Query: 241 KTREDPKENRKTKKE---------KFVESQ---VESESSVLNDSPFPEDDSEGLHSDSRE 288
+ +++ K K+++E K +++Q V S+ S+ P ED E
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Query: 289 EKQNTKSARERAG---QDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENR 345
K+ ++S A + G+ E P EEDT+ G + E+T
Sbjct: 460 SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET---E 516
Query: 346 KLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAE 405
K+E +E K P+++ ++ + E E+ + + G+E +D +
Sbjct: 517 KVEGNKVHIEVKENPEEEEEEEEEEE--EDEESEEEEEEEGESEGSEGDEEDEKVSDEKD 574
Query: 406 EDKETKRNESKE-----KYQKRHDSDKEEKGRKEPK 436
K + SKE +Y D KEE+ + K
Sbjct: 575 SGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAK 610
Score = 48.9 bits (115), Expect = 2e-05
Identities = 61/299 (20%), Positives = 119/299 (39%), Gaps = 47/299 (15%)
Query: 101 EVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQR 160
+ + E K+ E + + R++ +R+ ++ EA +++ E ++ K+K+K+ ++R
Sbjct: 342 KAMQEALAKLKEEEERQKREEEERIKRLEEL-EAKRKEEERLEQEKRERKKQKEKERKER 400
Query: 161 EEKSPDDLKKKKAKAGKLKD--------------------KSKPDLESSLESLVFDLRTK 200
+K L K + +A + K +P E +
Sbjct: 401 LKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLES 460
Query: 201 KRISEAKE-----ELKESKKPKKDEVK---ETKELKKVKKGEIRDLKTKTREDPKEN--- 249
K +SE+ E E+ E P+K+E E +E + + + D + ++ E
Sbjct: 461 KEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEG 520
Query: 250 -------RKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQ 302
++ +E+ E + E E + E +SEG D +EK S + +G+
Sbjct: 521 NKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKV---SDEKDSGK 577
Query: 303 DMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLE-NKNAFLEKKTVP 360
+ + E DS +++D R K R+ E R+LE +KN EK P
Sbjct: 578 TLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRI----EKRRLEHSKNVNTEKLRAP 632
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 80.5 bits (197), Expect = 6e-15
Identities = 88/492 (17%), Positives = 215/492 (43%), Gaps = 44/492 (8%)
Query: 50 DSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKK 109
+++ G+++ V L + E ++ ++ + ++ W E +++ +E + E +K
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQ---QEEKMWRQEEKIQEWEEKIQEQEEK 322
Query: 110 IAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLK 169
I E + K ++ + ++E +Q E + K++K+R++EE + +
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE-----KEEKMRRQEEMMWEKEE 377
Query: 170 KKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKK 229
K + + + +K E + L + +++I E +E+ +E +K ++ E ++ +E K
Sbjct: 378 KMRRQEEMMWEK-----EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 230 VKKGE-IRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDS-- 286
++ E IR+ + K RE K+ + ++EK E + E + E +H
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEI 491
Query: 287 --REEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTREN 344
++EK + + + R Q+ + EK + E + R+++K + E RE
Sbjct: 492 WRQKEKMHEQEEKIRK-QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 345 RKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSA 404
K+ + E++ K+Q +D+ E ++ +E +W +
Sbjct: 551 EKMHEQEKIWEEE---KRQEQEDKMWRQEE---------------KIREQEEKVWRQEEK 592
Query: 405 EEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSEN 464
++E KR E +EK K+ + +E++ + + + K ++ + ++T E++ + E
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 465 NRK----REEIPLDFKTI--DDHKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSV 518
K E++ +T+ + K +E ++ ++E+ E + E E + +
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Query: 519 CQADENSDGRQQ 530
C+ +E +++
Sbjct: 713 CEQEEKMQEQEE 724
Score = 72.4 bits (176), Expect = 2e-12
Identities = 91/464 (19%), Positives = 201/464 (43%), Gaps = 63/464 (13%)
Query: 19 DSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEE----DGEDVFEVEKILDMKTEGGKV 74
+ E++ E EE + E + R E + EE E ++E E+ + + E +
Sbjct: 318 EQEEKIREQEEKIR---EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE---M 371
Query: 75 LYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEA 134
+++ K ++ WE E + + +E + E ++KI E + K ++ R
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIR---------- 420
Query: 135 NSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLV 194
+Q+ +++ ++++K+R++EEK + KK + K+ ++ K E +
Sbjct: 421 ----EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 476
Query: 195 FDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGE--IRDLKTKTREDPKENRKT 252
R +++I E +E ++ +K + E K K+ +KV + E IR+ + K RE +E +
Sbjct: 477 EMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE--QEEKMW 534
Query: 253 KKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSR--EEKQNTKSARERAGQDMGLEHGF 310
++E+ + Q E + E +H + EE++ + + Q+ +
Sbjct: 535 RQEEKIREQEEMWR-----------EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE 583
Query: 311 EKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTREN----RKLENKNAFLEKKTVPKKQRNQ 366
EK E + R +++K ++ E RE ++ E K E+K +++ Q
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 367 DRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSD 426
++ + E E+ M + ++ +E +W + ++E K E +EK +++ +
Sbjct: 644 EQEEKMGEQEEKM-----CEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMM 698
Query: 427 KEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREE 470
+E++ + + K ++ EEK E +R+E
Sbjct: 699 QEQEEKMWEQEEKMCEQ------------EEKMQEQEEKMRRQE 730
Score = 35.4 bits (80), Expect = 0.23
Identities = 64/327 (19%), Positives = 128/327 (39%), Gaps = 33/327 (10%)
Query: 200 KKRISEAKEELKESKKPKKDEV----KETKELKKVKKGEIRDLKTKTR-EDPKENRKTKK 254
+ +++EAKE+L + V +TK+ KK+ G + T P++ +K
Sbjct: 57 QSKLAEAKEQLTDHHPQTNPSVGTAASDTKK-KKINNGTNPETTTSGGCHSPEDEQKASH 115
Query: 255 EKFVESQVESESSVLNDSPFPEDDSE---GLHSDSREEKQNTKSARERAGQDMGLEHGFE 311
+ + E E+ V +E L+ KQ AR+ + + F
Sbjct: 116 QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR-LHDSWKFA 174
Query: 312 KPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENR---------------KLENKNAFLEK 356
L+ A+SA +KKK R E+ + R +L+ KNA L++
Sbjct: 175 GELEQALSAV------ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 357 KTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESK 416
K + + + EL++ + + ++L E L + K + E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 417 EKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFK 476
E + + + +E+ R+E K + ++I+ + + E+ + E R++EE + ++
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE--MMWE 346
Query: 477 TIDDHKTKENKQSLKERRNTRDETDTW 503
+ + +E KE + R E W
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMW 373
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 79.0 bits (193), Expect = 2e-14
Identities = 83/449 (18%), Positives = 207/449 (46%), Gaps = 56/449 (12%)
Query: 97 EDCKEVLLEFRKKI--AENKAKAVRKDIQRLSLNND-----IFEANSDSDQQSETKEDTS 149
E+ K+ E ++K+ AE++ ++ +++ L + + + +++ Q+ +++
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
Query: 150 PKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEE 209
++++KK+R++EEK ++ + + GK++++ + R +KR+ E ++E
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK-----------MWRQEKRLREQEKE 329
Query: 210 LKESKKPKKD--EVKETKELKKVKKGEIRDLKTKTREDP-----KENRKTKKEKFVESQV 262
L+E +K ++ E++E +E + ++ ++ + + K RE +E R ++EK + Q
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ- 388
Query: 263 ESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEE 322
E + + + +D+ + E++ E+ ++ ++ +K D +E
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 323 DTDVRGRRKK-----KTPRKAED----TRENRKLENKNAFLEKKTVPKKQRNQDRSKSAA 373
+ +R R KK +T R+ E+ EN + + + +++ +K++ ++ K
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Query: 374 ELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEE-------------DKETK------RNE 414
+ EK+ + + G+E+ +W + E D+E K R E
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
Query: 415 SKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLD 474
K + Q++ D+EEK R+E + + K++R ++ + E+ + E +++EE
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE--KM 626
Query: 475 FKTIDDHKTKENKQSLKERRNTRDETDTW 503
++ + + +E K +E + E W
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
Score = 77.0 bits (188), Expect = 7e-14
Identities = 85/490 (17%), Positives = 210/490 (42%), Gaps = 47/490 (9%)
Query: 50 DSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKK 109
+ E++ + E+ + + E + +++ K ++ W E L + ++ + E +K
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 110 IAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLK 169
+ + + + +D + + E +Q + +E+ ++++KK R +EEK ++ +
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 170 -KKKAKAGKLKDKSKPDLESSL---ESLVFDLRTK----KRISEAKEELKESKKPKKDEV 221
+++ K + ++++ + E + E +++ K +R+ E KE+L E +K ++ E
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 222 KETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEG 281
K ++ +K IRD + ++ K R+ K + + E E + + D E
Sbjct: 512 KIWEQEEK-----IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 282 LHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDT 341
+ ++E+++ T E+ ++ E+ + E+ ++ +++K + E
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREE-------ERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 342 RENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWST 401
+E EK +++ + K + EK+ + + +RL ++ LW
Sbjct: 620 QEQE---------EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 402 DSAEEDKETKRNESK----EKYQKRHDSDK-----EEKGRKEPKGLKTLKEIRNAFDLFK 452
+ +E ++ + E K EK +K+ + +EK R+E + K++R ++ +
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 453 LTPEEKNDVSENNRKREE---------IPLDFKTIDDHKTKENKQSLKERRNTRDETDTW 503
E+ + E +++EE + K + + E K+ L E +++ W
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIW 790
Query: 504 AYIAAEGDQE 513
DQE
Sbjct: 791 EQEEKMRDQE 800
Score = 74.7 bits (182), Expect = 3e-13
Identities = 82/457 (17%), Positives = 195/457 (42%), Gaps = 58/457 (12%)
Query: 84 TSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDS----- 138
T ++ W E E L E KKI + + K R++ + + E
Sbjct: 269 TLQEEMWRQE-------EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 139 ---DQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVF 195
+Q+ E +E +++K+LR++EE+ + +K + K++++ + E ++
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ--EERLW 379
Query: 196 DLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKE 255
+ + R E K +E + ++DE KE + ++ ++ + K RE+ K + KK
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 256 KFVESQVESESSVLNDSPFPEDDSEGLHSD------------SREEK----QNTKSARER 299
+ E +++ E + ++ E + +EEK Q +E+
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
Query: 300 AGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKK----KTPRKAEDTR---------ENRK 346
+ ++ EK + + ++ G+ KK + R+ ED + +K
Sbjct: 500 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 347 LENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEE 406
+ ++ +EKKT ++++ D+ + E E++ + +++ EE + + +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERM------REREKKMREEEEMMREQEEKMQ 613
Query: 407 DKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNR 466
++E K E +EK ++ + +E++ + + K ++ ++ +L PE+K + E+ +
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL-PEQKEKLWEHEK 672
Query: 467 KREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTW 503
+E+ + + + + K +Q E++ E TW
Sbjct: 673 MQEQ-----EKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Score = 61.6 bits (148), Expect = 3e-09
Identities = 83/483 (17%), Positives = 192/483 (39%), Gaps = 49/483 (10%)
Query: 100 KEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQ 159
+E + E KK+ E + ++ + +++E QQ E +++K+++
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Query: 160 REEK---SPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKP 216
+EEK + ++ ++ G+ K + + E +++ K R E K +E +
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568
Query: 217 KKDEVKETK------ELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLN 270
KK + +E K ++++ ++ R+ K + E+ ++ K ++ E E E +
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE 628
Query: 271 DSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRR 330
++ E + E+++ E+ + L EK + E++
Sbjct: 629 QEEKMQEQEEKMW----EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE------- 677
Query: 331 KKKTPRKAEDTRENRKLENKNAFLEKKT-----VPKKQRNQDRSKSAAELEKLMPVSAQ- 384
K + E E K+E K EKKT + +++ ++R K E E++M +
Sbjct: 678 --KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK 735
Query: 385 -TPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKE 443
+ ++ +E +W + ++E K E + +++ + EK +++ K + ++
Sbjct: 736 MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK 795
Query: 444 IRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTW 503
+R+ + + E+ E R +EE +E K +E + E W
Sbjct: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEE---------KMWGQEEKMWGQEEKMWGQEEKMW 846
Query: 504 AYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATD 563
G +E ++ Q E Q+ G + K+ + ++ + G++E
Sbjct: 847 ------GQEEKMEEKMQGQEEKMREQEEKMRGQE-----EKMREQEEKMRGQEEKIYCVG 895
Query: 564 AIP 566
+ P
Sbjct: 896 SPP 898
Score = 52.8 bits (125), Expect = 1e-06
Identities = 72/318 (22%), Positives = 134/318 (42%), Gaps = 30/318 (9%)
Query: 212 ESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLND 271
E K K E++E L + +K EI+ L K + RK ++ KF+ QV++ + L +
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQ-LNVKELK-----RKLERAKFLLPQVQTNT--LQE 272
Query: 272 SPFPEDDSEGLHSDSREEKQNTKSAR--ERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ +++ E + + KQ K R ER + G E+ + + + R
Sbjct: 273 EMWRQEE-ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Query: 330 RKKKTPRKAEDTRENRKL-----------ENKNAFLEKKTVPKKQRNQDRSKSAAELEKL 378
++K R+ ++ RE + E K E+K +++R ++ K E E+
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 379 MPVSAQT--PKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPK 436
M + + RL +E + + E E R E K + Q++ D+EEK ++E +
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 437 GLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNT 496
+ K++R + + E+ EN ++EE K + E K+ L E+
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEE-----KEWQQQRLPEQKEKLWEQEKM 506
Query: 497 RD-ETDTWAYIAAEGDQE 513
++ E W DQE
Sbjct: 507 QEQEEKIWEQEEKIRDQE 524
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 77.8 bits (190), Expect = 4e-14
Identities = 42/134 (31%), Positives = 83/134 (61%), Gaps = 1/134 (0%)
Query: 593 NLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI 652
++DQE ++ MT +++A GG ++ ++ + VN K+G TAL+ A+++ V
Sbjct: 195 DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
Query: 653 LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA-KQSN 711
LL+AG +VN+ +G+T L+ A + G+ +IVR +++ AD +I + +AL++A ++ N
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
Query: 712 NVLVYDLLKNHLET 725
+V D+L+ + +T
Sbjct: 315 ATMVRDILQCNPDT 328
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 2/170 (1%)
Query: 550 KHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAA 609
KHL + A L AVK G +VK L N NL +D G T +M+A+
Sbjct: 187 KHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKD--GNTALMIAS 244
Query: 610 AGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGET 669
G ++++ L+ G VN ++G T LI A + V LL+ A ++++ + +T
Sbjct: 245 KEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKT 304
Query: 670 ALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
AL A ++GN+ +VR +++C D I +K + L A + N+ V +LL
Sbjct: 305 ALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/116 (38%), Positives = 66/116 (56%), Gaps = 1/116 (0%)
Query: 605 VMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQ 664
++ AA G D++ LL+ GAKVN K GTT L+ AA K L V LL GA V+ +
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 665 SNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA-KQSNNVLVYDLL 719
+N TAL+ A K G + V+ +++ + N+ K N+AL A K+ + +V DLL
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/170 (29%), Positives = 87/170 (51%), Gaps = 2/170 (1%)
Query: 550 KHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAA 609
K + ++ N TD + L A K G V+ L++ N+ D SG T+++ A
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIP--DRSGDTVLIGAV 277
Query: 610 AGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGET 669
GG +++R L+ K A ++ R ++ TAL A EK T V +L+ + +GET
Sbjct: 278 RGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGET 337
Query: 670 ALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
L+KA K N ++V L+++ GA + + K ++ LH A + + + +LL
Sbjct: 338 PLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELL 387
Score = 62.4 bits (150), Expect = 2e-09
Identities = 39/130 (30%), Positives = 72/130 (55%), Gaps = 1/130 (0%)
Query: 593 NLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI 652
++D+ + G T +M+AA G ++++ LI GA N + TALI A+++ + V
Sbjct: 30 DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
Query: 653 LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNN 712
LL+ G + + G TALM AC +G +D+V L++ GA+ ++ + + +A +
Sbjct: 90 LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
Query: 713 V-LVYDLLKN 721
+V+ LL+N
Sbjct: 150 ADIVHLLLQN 159
Score = 57.4 bits (137), Expect = 6e-08
Identities = 39/128 (30%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 598 DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAG 657
D G T ++ AA G + ++ L+ GA V+ N TALI A + + +V +L+
Sbjct: 167 DKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRN 226
Query: 658 AFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV-LVY 716
VN+ +G TALM A K G+++IV+ +++ G NI + ++ L A + +V +V
Sbjct: 227 PNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVR 286
Query: 717 DLLKNHLE 724
LL+ + +
Sbjct: 287 ALLQKYAD 294
Score = 49.3 bits (116), Expect = 2e-05
Identities = 34/106 (32%), Positives = 55/106 (51%)
Query: 617 LRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACK 676
L+ L+ K V+ R + G T L+ AAE+ L V L++ GA N++ + TAL+ A K
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 677 RGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
G+ IV +++CG + +AL +A V +LL +H
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH 126
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/85 (32%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 637 ALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNIL 696
++I+ E+ + + LLE V+ + G+T LM A ++GN +IV+ +I+ GA+CN+
Sbjct: 8 SVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE 67
Query: 697 SKHQNSALHFAKQSNNV-LVYDLLK 720
+AL A + +V +V +LLK
Sbjct: 68 DLDNWTALISASKEGHVHIVEELLK 92
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 77.8 bits (190), Expect = 4e-14
Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 2/150 (1%)
Query: 573 AVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQK 632
A + G Y V++ L + N+DQ G + +AA G D++ LL + GA VN +
Sbjct: 887 ASQEGHYDCVQILLENKS--NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Query: 633 NGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
+G L A +N LT LE GA V + G TAL +C +G+ ++V+++I AD
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD 1004
Query: 693 CNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
N + SAL A +V V LL H
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/259 (28%), Positives = 112/259 (43%), Gaps = 20/259 (7%)
Query: 479 DDHKTKENKQSLKERRNTRDETDTWAYI-AAEGDQEVLDSVCQADENSDGRQQILSLGMD 537
DD + +Q+L+ + R D A + + + L + + D ++S G D
Sbjct: 511 DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGAD 570
Query: 538 LQLEW------MKLEDFQKH------LDGKDENFAATDAIPSNVLRDAVKNGDYITVKVA 585
L++E + L Q H L G N TD LR A G V
Sbjct: 571 LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSAL 630
Query: 586 LNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKN 645
L + + +D D+ T + AA GG +D++ L+ GA+VN G TALI AA
Sbjct: 631 LYAGVK--VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMG 688
Query: 646 FLTTVAILLEAGAFVNVQQSNGETALMKA-----CKRGNSDIVRLVIECGADCNILSKHQ 700
V LL+ GA VN + +G TAL A +G++ +V L+I+ GA+ + K
Sbjct: 689 HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 701 NSALHFAKQSNNVLVYDLL 719
+ L A +V V DLL
Sbjct: 749 MTPLLVAAYEGHVDVVDLL 767
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/136 (33%), Positives = 68/136 (50%)
Query: 584 VALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAE 643
V+L + +D D GMT +++AA G D++ LL+ GA V+ NG T L+ AA
Sbjct: 731 VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
Query: 644 KNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSA 703
+ V LL GA V+ S G T L A +GN ++VR +++ G D N +
Sbjct: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTP 850
Query: 704 LHFAKQSNNVLVYDLL 719
LH A + L+ + L
Sbjct: 851 LHMAAFEGHRLICEAL 866
Score = 64.7 bits (156), Expect = 4e-10
Identities = 60/212 (28%), Positives = 99/212 (46%), Gaps = 15/212 (7%)
Query: 485 ENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQ--ADEN---SDGRQQILSLGMDLQ 539
ENK ++ +R D + A EG +++++ + AD N +DGR + L ++ Q
Sbjct: 901 ENKSNIDQRGY--DGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 540 LEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDS 599
L ++ N A+DA L + G V+V + + + N D+
Sbjct: 959 LT------MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA--ADN 1010
Query: 600 SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF 659
+ + AA G +++LLI GA V+ G TAL AA++ + V +LLE GA
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070
Query: 660 VNVQQSNGETALMKACKRGNSDIVRLVIECGA 691
N G TA+ A K G+S I++L+ + GA
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/130 (28%), Positives = 71/130 (54%)
Query: 593 NLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI 652
N++ D+ G T + ++ G +++++LI A VN +AL AA + + V +
Sbjct: 971 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 1030
Query: 653 LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNN 712
L+E GA V+ + G TAL A + G+ D+V++++E GAD N + +A+ A ++ +
Sbjct: 1031 LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGH 1090
Query: 713 VLVYDLLKNH 722
+ LL+ +
Sbjct: 1091 SQIIKLLEKY 1100
Score = 62.8 bits (151), Expect = 1e-09
Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 5/127 (3%)
Query: 594 LDQEDSSGMTLVMLAA-----AGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLT 648
++ ED G T + +AA + G ++ LLI +GA+V+ K+G T L+ AA + +
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 649 TVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAK 708
V +LLE GA V+ +NG T L+ A G++ +V ++ GA + + + L A
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Query: 709 QSNNVLV 715
NV V
Sbjct: 823 AQGNVEV 829
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/212 (27%), Positives = 96/212 (45%), Gaps = 5/212 (2%)
Query: 511 DQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVL 570
+QEVL + +A + + S + LE ED + L + D+ +L
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALE---REDSIRTLLDNGASVNQCDSNGRTLL 549
Query: 571 RDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGR 630
+A +G V + ++ + L+ ED+ G T + LAA G ++ LI GA +N
Sbjct: 550 ANAAYSGSLDVVNLLVSRGAD--LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHT 607
Query: 631 QKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECG 690
++G TAL AA V+ LL AG V+ ++ TAL A G+ DIV +++ G
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 691 ADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
A+ N +AL A + + + L +H
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 60.1 bits (144), Expect = 9e-09
Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 7/162 (4%)
Query: 563 DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLIT 622
DA LR A G V L E N + D+ G T ++ AA G +++ L+
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVN--KADNEGRTALIAAAYMGHREIVEHLLD 698
Query: 623 KGAKVNGRQKNGTTALIHAA-----EKNFLTTVAILLEAGAFVNVQQSNGETALMKACKR 677
GA+VN +G TAL AA K + V++L++ GA V+ +G T L+ A
Sbjct: 699 HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
Query: 678 GNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
G+ D+V L++E GAD + + + L A + V + L
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 56.6 bits (135), Expect = 1e-07
Identities = 46/157 (29%), Positives = 70/157 (44%), Gaps = 5/157 (3%)
Query: 560 AATDAIPSN---VLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDL 616
AA D+I S VL A G+ V+ L+ + N D +G T + +AA G +
Sbjct: 805 AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN--HRDDAGWTPLHMAAFEGHRLI 862
Query: 617 LRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACK 676
LI +GA+ N +G I A+++ V ILLE + ++ + +G AL A
Sbjct: 863 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
Query: 677 RGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
G+ DIV L+ GAD N L+ N +
Sbjct: 923 EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
>gi|221307494 chromodomain protein, Y chromosome-like isoform a
[Homo sapiens]
Length = 544
Score = 77.0 bits (188), Expect = 7e-14
Identities = 57/177 (32%), Positives = 90/177 (50%), Gaps = 14/177 (7%)
Query: 56 EDVFEVEKILDM-KTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENK 114
E+++EVE+I+D K + GK Y VRWKGY S+DDTWEPE HL +C+E + +F ++ E +
Sbjct: 4 EELYEVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQ 63
Query: 115 AKAVRKDIQRLSLNN---DIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKK 171
++ R S NN I + + + ++ K K + K Q S K +
Sbjct: 64 KESTLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQ---KFR 120
Query: 172 KAKAGKLKDKSKPDL-ESSLESLVFDLRTKKRI------SEAKEELKESKKPKKDEV 221
K A L + DL +S ++ LV K R SE+ E+L ++ ++D V
Sbjct: 121 KNTAPSLSSRKNMDLAKSGIKILVPKSPVKSRTAVDGFQSESPEKLDPVEQGQEDTV 177
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 84 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 141
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 142 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 201
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 202 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 247
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 3/111 (2%)
Query: 613 QDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL-EAGAFVNVQQSNGETAL 671
Q L L K K N KN L+ A E VA LL + GA S G+TA
Sbjct: 2 QPTYLPWLSAKEKKTNEWNKNDDR-LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAF 60
Query: 672 MKACKRGNSDIVRLVIECGADCNILSKHQNSALHF-AKQSNNVLVYDLLKN 721
A +G+ + +R++I G D +SALH AK S++ + LL++
Sbjct: 61 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 111
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 625 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 684
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 685 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 743
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 744 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 798
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 799 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 852
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 853 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 893
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 321 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 380
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 381 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 440
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 441 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 500
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 501 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 551
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 552 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 593
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 594 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 647
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 648 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 686
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 73 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 130
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 131 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 190
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 191 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 236
Score = 40.0 bits (92), Expect = 0.009
Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 3/99 (3%)
Query: 625 AKVNGRQKNGTTALIHAAEKNFLTTVAILL-EAGAFVNVQQSNGETALMKACKRGNSDIV 683
AK N KN L+ A E VA LL + GA S G+TA A +G+ + +
Sbjct: 3 AKTNEWNKNDDR-LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 684 RLVIECGADCNILSKHQNSALHF-AKQSNNVLVYDLLKN 721
R++I G D +SALH AK S++ + LL++
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 100
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 614 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 673
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 674 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 732
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 733 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 787
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 788 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 841
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 882
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 310 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 369
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 370 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 429
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 430 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 489
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 490 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 540
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 541 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 582
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 583 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 636
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 637 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 675
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 244
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 593 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 652
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 653 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 711
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 712 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 766
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 767 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 820
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 821 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 861
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 289 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 348
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 349 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 408
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 409 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 468
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 469 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 519
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 520 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 561
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 562 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 615
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 616 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 654
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 244
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 622 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 681
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 740
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 741 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 795
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 796 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 849
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 890
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 318 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 377
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 378 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 437
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 438 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 497
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 498 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 548
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 549 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 590
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 591 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 644
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 645 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 683
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 244
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 622 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 681
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 740
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 741 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 795
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 796 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 849
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 890
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 318 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 377
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 378 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 437
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 438 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 497
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 498 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 548
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 549 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 590
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 591 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 644
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 645 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 683
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/172 (30%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 561 ATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLL 620
A D + L A KN + ++ L S + + DSSG T + AAA G +++L
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQS--KCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 621 ITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNS 680
+ +N + +G L+ A + LL+ GA VN + +G TALM AC+ G+S
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
Query: 681 DIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEE 732
+ V +I+ GAD N++ +ALH++K S N + LL LS+++++
Sbjct: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL------LSKISQD 244
Score = 36.6 bits (83), Expect = 0.10
Identities = 55/281 (19%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 19 DSTEELAEVEEGVG-VVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDM------KTEG 71
++++E +++E + ++ E N + ++ + +++ + ED + + + D+ K E
Sbjct: 622 EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 681
Query: 72 GKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
K++ ++D E + L + ++ + K +V + L + +
Sbjct: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV-SITEHLQVITTL 740
Query: 132 FEANSDSDQQ-SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPD-LESS 189
A + +++ S KE + K+ + +++ L++K A + +S + L+SS
Sbjct: 741 RTAAKEMEEKISNLKEHLASKEVEVAKLEKQL-----LEEKAAMTDAMVPRSSYEKLQSS 795
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKT--KTREDPK 247
LES V L +K KE +KE +K + V+ E+ +VK+ E +++T K++E
Sbjct: 796 LESEVSVLASK-----LKESVKEKEKVHSEVVQIRSEVSQVKR-EKENIQTLLKSKEQEV 849
Query: 248 ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSRE 288
K ++ E E + + S ED + ++ S+E
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE 890
Score = 32.7 bits (73), Expect = 1.5
Identities = 76/401 (18%), Positives = 153/401 (38%), Gaps = 65/401 (16%)
Query: 117 AVRKDIQRLSLN----NDIFEANSDSDQQS-----ETKEDTSPKKKKKKLRQREEKSPDD 167
++R++ RLS + + + + +S++DQQ + K + K+ + + KSP +
Sbjct: 318 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 377
Query: 168 LKKKKA-------------KAGKLKDKSKPDLESSLESLVFDLRTKK-----RISEAKEE 209
+ + GK + S PD +SS L+ L RI + +E
Sbjct: 378 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI 437
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVL 269
L++ +K + E K+L+ + +L + EN +K E+Q + E ++
Sbjct: 438 LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 497
Query: 270 NDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ GL S + + +++ + ++ L +A+ E R
Sbjct: 498 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV---LKQDLQNALEESE------R 548
Query: 330 RKKKTPRKAEDTRENRKLENKNAFLEKKTV---PKKQRNQDRSKSAAELEKLMPVSAQTP 386
K+K R+LE K EK TV P ++ + +S + +E +
Sbjct: 549 NKEKV----------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENM-------- 590
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+E+ E +E + + K Q ++ E + KE + +
Sbjct: 591 ------NKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ 644
Query: 447 AFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+L +L E + ++ E+ RKR+ + D HK + K
Sbjct: 645 VSELSQLYKEAQAEL-EDYRKRKSLE-DVTAEYIHKAEHEK 683
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 75.9 bits (185), Expect = 2e-13
Identities = 113/516 (21%), Positives = 211/516 (40%), Gaps = 71/516 (13%)
Query: 49 GDSEEDGEDVFEVEKILDMKTEGGKVLYKV-RWKGYTSDDDTWEPEIHLEDC-------K 100
GDS + ED + + K+L K R + S DT + + + C K
Sbjct: 1033 GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK 1092
Query: 101 EVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQR 160
+ L R+ ++ +K K+IQ S ++D E++ D+ ++ K+ TS KKK ++++
Sbjct: 1093 RIELRERRNLS---SKRNTKEIQSGSSSSDAEESSEDNKKK---KQRTSSKKKAVIVKEK 1146
Query: 161 EEKSPDDLKKKKAKAGKLKDKSKPDLESS------------------LESLVFDLRTKKR 202
+ S K+K + S D+E E+LV T
Sbjct: 1147 KRNSLRTSTKRKQ--ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFC 1204
Query: 203 ISEAKEELKESKKPKKDEVKETKE----------LKKVKKGEIRDLKTKTREDPKENRKT 252
S E L +S D+ + + L+++K D + ++P+E +K
Sbjct: 1205 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR 1264
Query: 253 KKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEK 312
++ E+ + E+ +S E DS+ +S++ + + R + G E G EK
Sbjct: 1265 TGKQNEENPGDEEAKNQVNS---ESDSDS--EESKKPRYRHRLLRHKLTVSDG-ESGEEK 1318
Query: 313 PLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSA 372
+E +V+GR ++K +ED+ E+ + E +QR + RS
Sbjct: 1319 KT----KPKEHKEVKGRNRRKV--SSEDS-EDSDFQESGVSEEVSESEDEQRPRTRSAKK 1371
Query: 373 AELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGR 432
AELE+ Q K RR+ +E S E++E ++ E +E+ ++ + +++E
Sbjct: 1372 AELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1431
Query: 433 KEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKE 492
+ G K K+IR KL E +N + E +R+ I + + ++ L+E
Sbjct: 1432 SKSPG-KGRKKIRKILKDDKLRTETQNALKEEEERRKRIA---------EREREREKLRE 1481
Query: 493 RRNTRDETDTWAYIAA----EGDQEVLDSVCQADEN 524
D + T I + D+E + + Q N
Sbjct: 1482 VIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRN 1517
Score = 58.2 bits (139), Expect = 3e-08
Identities = 110/528 (20%), Positives = 205/528 (38%), Gaps = 62/528 (11%)
Query: 19 DSTEELAEVEEGVGVVGEDN-DAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYK 77
DS+E+ ++G+ G N + G+ + +++ E E +D T ++ +
Sbjct: 810 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR 869
Query: 78 VRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVR---KDIQRLSLN-NDIFE 133
+ K S ++ ++ LE RK +AE K K+ K +++ +DI E
Sbjct: 870 LPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKHLKTKTCKKVQDGLSDIAE 928
Query: 134 ANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESL 193
DQ ET ED KK+ K E+K P D KKK K + + S E
Sbjct: 929 KFLKKDQSDETSEDD---KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK----- 980
Query: 194 VFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTK 253
L ++ I + +K+ K D K++K +IRD KT
Sbjct: 981 ---LPEREEICHFPKGIKQIKNGTTDGEKKSK--------KIRD-------------KTS 1016
Query: 254 KEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNT----KSARERAGQDMGLEHG 309
K+K S +S+ DS +D + + EK+ KS+R+R
Sbjct: 1017 KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEK 1076
Query: 310 FEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRS 369
+ D S+++ R+++ +T+E + + + E KK++ + S
Sbjct: 1077 YSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSS 1136
Query: 370 KSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDK----ETKRNESKEKYQKRHDS 425
K A + K ++ +R + S+D ++D+ E +E K K +
Sbjct: 1137 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV 1196
Query: 426 DKEEKGRKEPKGLKTL-KEIRNAFDLFKLTPEEKNDVSENNRKR---EEIPLDFKTIDDH 481
G + G + L K + D ++ ND K+ EEI + + +D
Sbjct: 1197 LSSHTGFCQSSGDEALSKSVPVTVD----DDDDDNDPENRIAKKMLLEEIKANLSSDEDG 1252
Query: 482 KTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQ 529
+ + + K+R ++E + GD+E + V ++ +SD +
Sbjct: 1253 SSDDEPEEGKKRTGKQNEEN-------PGDEEAKNQV-NSESDSDSEE 1292
Score = 51.2 bits (121), Expect = 4e-06
Identities = 70/378 (18%), Positives = 151/378 (39%), Gaps = 46/378 (12%)
Query: 201 KRISEAKEELKESKKPKKDEVKETKELK-KVKKGEIRDLKTKTREDPKENR--KTKKEKF 257
+R +E S + + VKE ++L V+K + R+ ++PK N+ K+K+ +
Sbjct: 627 RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSET 686
Query: 258 VESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSA 317
V+ +S+ + ++ S HS S + N + D+ + G
Sbjct: 687 VDQNSDSDEMLA----ILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAG-------- 734
Query: 318 MSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEK 377
D +G+RK+K+ D + K++ + KK K+Q + S +ELEK
Sbjct: 735 ------KDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKK---KRQTQSESSNYDSELEK 785
Query: 378 LMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKR---NESKEKYQKRHDSDKEEKGRKE 434
+ ++ R DS+E++K +K+ N+ + + + ++ RK+
Sbjct: 786 EIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ 845
Query: 435 PKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERR 494
+ +T D E ++ + K+++ +D KE + E R
Sbjct: 846 ER--ETFSSAEGTVDKDTTIMELRDRLP----KKQQASASTDGVDKLSGKEQSFTSLEVR 899
Query: 495 NTRDETDTWAYIAAEGDQEVLDSVC----------QADENSDGRQQILSLGMDLQLEWMK 544
+ + ++ + ++V D + Q+DE S+ ++ G + E K
Sbjct: 900 KVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTE---EKKK 956
Query: 545 LEDFQKHLDGKDENFAAT 562
DF+K + ++ + ++
Sbjct: 957 PSDFKKKVIKMEQQYESS 974
Score = 50.4 bits (119), Expect = 7e-06
Identities = 89/453 (19%), Positives = 186/453 (41%), Gaps = 50/453 (11%)
Query: 117 AVRKDIQRLSLNN----DIFEANSDS----DQQSET-KEDTSPKKKKKKLRQREEKSPDD 167
A+ K++ R+S ++ DI E +++ D +++ K+D +K+K S D
Sbjct: 698 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRK------SSTSGSD 751
Query: 168 LKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKE--ELKESKK--PKKDEVKE 223
KK K+ K SK ++ ES +D +K I + + +KK P +
Sbjct: 752 FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS 811
Query: 224 TKELKKVKKG----EIRDLKTKTREDPKE-NRKTKKEKF--VESQVESESSVLN-DSPFP 275
+++ K KKG ++LKT + RK ++E F E V+ +++++ P
Sbjct: 812 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 871
Query: 276 EDDSEGLHSD------SREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ +D +E+ + R+ A +H K D +
Sbjct: 872 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 931
Query: 330 RKKKTPRKAEDTRENRKL----ENKNAFLEKKTVPKKQR---NQDRSKSAAELEKL--MP 380
+K ++ +ED ++ K + K + +KK + +Q+ + D ++ E E++ P
Sbjct: 932 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 991
Query: 381 VSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKT 440
+ K GE++ D + K+ + ++ EK + DS + +K G
Sbjct: 992 KGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050
Query: 441 LKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDET 500
++ R L + ++ D S ++ ++ + D D + K + L+ERRN +
Sbjct: 1051 REKKR--CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK--RIELRERRNLSSKR 1106
Query: 501 DTWAYIAAEGDQEVLDSVCQADENSDGRQQILS 533
+T + + +S +++N +Q+ S
Sbjct: 1107 NTKEIQSGSSSSDAEES---SEDNKKKKQRTSS 1136
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 75.9 bits (185), Expect = 2e-13
Identities = 113/516 (21%), Positives = 211/516 (40%), Gaps = 71/516 (13%)
Query: 49 GDSEEDGEDVFEVEKILDMKTEGGKVLYKV-RWKGYTSDDDTWEPEIHLEDC-------K 100
GDS + ED + + K+L K R + S DT + + + C K
Sbjct: 1071 GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK 1130
Query: 101 EVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQR 160
+ L R+ ++ +K K+IQ S ++D E++ D+ ++ K+ TS KKK ++++
Sbjct: 1131 RIELRERRNLS---SKRNTKEIQSGSSSSDAEESSEDNKKK---KQRTSSKKKAVIVKEK 1184
Query: 161 EEKSPDDLKKKKAKAGKLKDKSKPDLESS------------------LESLVFDLRTKKR 202
+ S K+K + S D+E E+LV T
Sbjct: 1185 KRNSLRTSTKRKQ--ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFC 1242
Query: 203 ISEAKEELKESKKPKKDEVKETKE----------LKKVKKGEIRDLKTKTREDPKENRKT 252
S E L +S D+ + + L+++K D + ++P+E +K
Sbjct: 1243 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR 1302
Query: 253 KKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEK 312
++ E+ + E+ +S E DS+ +S++ + + R + G E G EK
Sbjct: 1303 TGKQNEENPGDEEAKNQVNS---ESDSDS--EESKKPRYRHRLLRHKLTVSDG-ESGEEK 1356
Query: 313 PLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSA 372
+E +V+GR ++K +ED+ E+ + E +QR + RS
Sbjct: 1357 KT----KPKEHKEVKGRNRRKV--SSEDS-EDSDFQESGVSEEVSESEDEQRPRTRSAKK 1409
Query: 373 AELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGR 432
AELE+ Q K RR+ +E S E++E ++ E +E+ ++ + +++E
Sbjct: 1410 AELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
Query: 433 KEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKE 492
+ G K K+IR KL E +N + E +R+ I + + ++ L+E
Sbjct: 1470 SKSPG-KGRKKIRKILKDDKLRTETQNALKEEEERRKRIA---------EREREREKLRE 1519
Query: 493 RRNTRDETDTWAYIAA----EGDQEVLDSVCQADEN 524
D + T I + D+E + + Q N
Sbjct: 1520 VIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRN 1555
Score = 58.2 bits (139), Expect = 3e-08
Identities = 110/528 (20%), Positives = 205/528 (38%), Gaps = 62/528 (11%)
Query: 19 DSTEELAEVEEGVGVVGEDN-DAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYK 77
DS+E+ ++G+ G N + G+ + +++ E E +D T ++ +
Sbjct: 848 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR 907
Query: 78 VRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVR---KDIQRLSLN-NDIFE 133
+ K S ++ ++ LE RK +AE K K+ K +++ +DI E
Sbjct: 908 LPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKHLKTKTCKKVQDGLSDIAE 966
Query: 134 ANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESL 193
DQ ET ED KK+ K E+K P D KKK K + + S E
Sbjct: 967 KFLKKDQSDETSEDD---KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK----- 1018
Query: 194 VFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTK 253
L ++ I + +K+ K D K++K +IRD KT
Sbjct: 1019 ---LPEREEICHFPKGIKQIKNGTTDGEKKSK--------KIRD-------------KTS 1054
Query: 254 KEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNT----KSARERAGQDMGLEHG 309
K+K S +S+ DS +D + + EK+ KS+R+R
Sbjct: 1055 KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEK 1114
Query: 310 FEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRS 369
+ D S+++ R+++ +T+E + + + E KK++ + S
Sbjct: 1115 YSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSS 1174
Query: 370 KSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDK----ETKRNESKEKYQKRHDS 425
K A + K ++ +R + S+D ++D+ E +E K K +
Sbjct: 1175 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV 1234
Query: 426 DKEEKGRKEPKGLKTL-KEIRNAFDLFKLTPEEKNDVSENNRKR---EEIPLDFKTIDDH 481
G + G + L K + D ++ ND K+ EEI + + +D
Sbjct: 1235 LSSHTGFCQSSGDEALSKSVPVTVD----DDDDDNDPENRIAKKMLLEEIKANLSSDEDG 1290
Query: 482 KTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQ 529
+ + + K+R ++E + GD+E + V ++ +SD +
Sbjct: 1291 SSDDEPEEGKKRTGKQNEEN-------PGDEEAKNQV-NSESDSDSEE 1330
Score = 51.2 bits (121), Expect = 4e-06
Identities = 70/378 (18%), Positives = 151/378 (39%), Gaps = 46/378 (12%)
Query: 201 KRISEAKEELKESKKPKKDEVKETKELK-KVKKGEIRDLKTKTREDPKENR--KTKKEKF 257
+R +E S + + VKE ++L V+K + R+ ++PK N+ K+K+ +
Sbjct: 665 RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSET 724
Query: 258 VESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSA 317
V+ +S+ + ++ S HS S + N + D+ + G
Sbjct: 725 VDQNSDSDEMLA----ILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAG-------- 772
Query: 318 MSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEK 377
D +G+RK+K+ D + K++ + KK K+Q + S +ELEK
Sbjct: 773 ------KDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKK---KRQTQSESSNYDSELEK 823
Query: 378 LMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKR---NESKEKYQKRHDSDKEEKGRKE 434
+ ++ R DS+E++K +K+ N+ + + + ++ RK+
Sbjct: 824 EIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ 883
Query: 435 PKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERR 494
+ +T D E ++ + K+++ +D KE + E R
Sbjct: 884 ER--ETFSSAEGTVDKDTTIMELRDRLP----KKQQASASTDGVDKLSGKEQSFTSLEVR 937
Query: 495 NTRDETDTWAYIAAEGDQEVLDSVC----------QADENSDGRQQILSLGMDLQLEWMK 544
+ + ++ + ++V D + Q+DE S+ ++ G + E K
Sbjct: 938 KVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTE---EKKK 994
Query: 545 LEDFQKHLDGKDENFAAT 562
DF+K + ++ + ++
Sbjct: 995 PSDFKKKVIKMEQQYESS 1012
Score = 50.4 bits (119), Expect = 7e-06
Identities = 89/453 (19%), Positives = 186/453 (41%), Gaps = 50/453 (11%)
Query: 117 AVRKDIQRLSLNN----DIFEANSDS----DQQSET-KEDTSPKKKKKKLRQREEKSPDD 167
A+ K++ R+S ++ DI E +++ D +++ K+D +K+K S D
Sbjct: 736 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRK------SSTSGSD 789
Query: 168 LKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKE--ELKESKK--PKKDEVKE 223
KK K+ K SK ++ ES +D +K I + + +KK P +
Sbjct: 790 FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS 849
Query: 224 TKELKKVKKG----EIRDLKTKTREDPKE-NRKTKKEKF--VESQVESESSVLN-DSPFP 275
+++ K KKG ++LKT + RK ++E F E V+ +++++ P
Sbjct: 850 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 909
Query: 276 EDDSEGLHSD------SREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGR 329
+ +D +E+ + R+ A +H K D +
Sbjct: 910 KKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL 969
Query: 330 RKKKTPRKAEDTRENRKL----ENKNAFLEKKTVPKKQR---NQDRSKSAAELEKL--MP 380
+K ++ +ED ++ K + K + +KK + +Q+ + D ++ E E++ P
Sbjct: 970 KKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP 1029
Query: 381 VSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKT 440
+ K GE++ D + K+ + ++ EK + DS + +K G
Sbjct: 1030 KGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088
Query: 441 LKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDET 500
++ R L + ++ D S ++ ++ + D D + K + L+ERRN +
Sbjct: 1089 REKKR--CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK--RIELRERRNLSSKR 1144
Query: 501 DTWAYIAAEGDQEVLDSVCQADENSDGRQQILS 533
+T + + +S +++N +Q+ S
Sbjct: 1145 NTKEIQSGSSSSDAEES---SEDNKKKKQRTSS 1174
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 75.5 bits (184), Expect = 2e-13
Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 1/154 (0%)
Query: 569 VLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVN 628
+L+ A G+ + + LN E +++ G + + AA G D +RLL++ A+VN
Sbjct: 713 LLQQAAAQGNVTLLSMLLNE-EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 629 GRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIE 688
KNG T L AA + V +L+ A +N G+T L ACK GN + ++L++E
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 689 CGADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
G + ++ + + +H A + NV LL H
Sbjct: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH 865
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/129 (28%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 605 VMLAAAGGQDDLLRLLITKG-AKVNGRQKNGTTALIHAAEKNFLTTVAILL-EAGAFVNV 662
+++ A+G L LL++ G A + GR T L AA + +T +++LL E G +N
Sbjct: 684 LLVTASGWSPSLTPLLMSGGPAPLAGRP----TLLQQAAAQGNVTLLSMLLNEEGLDINY 739
Query: 663 QQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
+G +AL A K G++D VRL++ A N K+ + L A + +LL ++
Sbjct: 740 SCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY 799
Query: 723 LETLSRVAE 731
++ A+
Sbjct: 800 DANINHAAD 808
Score = 35.8 bits (81), Expect = 0.17
Identities = 45/229 (19%), Positives = 94/229 (41%), Gaps = 12/229 (5%)
Query: 111 AENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKED----TSPKKKKKKLRQREEKSPD 166
A K +++ R +LN+ D + + KE T+P + + +K +
Sbjct: 64 ARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQE 123
Query: 167 DLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKE 226
+ + A A + K + + L+ + KK + +EE ++K+ VKE K+
Sbjct: 124 RMSAQLAAAESRQKKLEME---KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ 180
Query: 227 L--KKVKKGE-IRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDS--EG 281
L K +++ + + D+ K E+ K+ + ++E E + +E + E D+ E
Sbjct: 181 LSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQ 240
Query: 282 LHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRR 330
L + E+ +T +E + + ++ DS S + RR
Sbjct: 241 LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRR 289
Score = 34.3 bits (77), Expect = 0.51
Identities = 55/200 (27%), Positives = 85/200 (42%), Gaps = 26/200 (13%)
Query: 348 ENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQT-----PKGRRLSG---EERGLW 399
E++ LE + + + Q+ K AA LE+ + Q + ++LSG EE
Sbjct: 133 ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL 192
Query: 400 STDSA---EEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPE 456
A EE K+T E + +KR ++ E + K+ T +E A KL E
Sbjct: 193 EDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRA----KLNRE 248
Query: 457 EKNDVSENNRKREEIPLDFKTIDDHKT-KENKQSLKERRNTRDETDTWAYIAAEGDQEVL 515
E + +EEI K I+ K ++K SL R T+D + EG V
Sbjct: 249 E----AHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEG--TVT 302
Query: 516 DSV-CQAD---ENSDGRQQI 531
SV CQ D EN+D +++
Sbjct: 303 RSVACQTDLVTENADHMKKL 322
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 75.5 bits (184), Expect = 2e-13
Identities = 49/147 (33%), Positives = 80/147 (54%), Gaps = 1/147 (0%)
Query: 573 AVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQK 632
A + G+ +K+ LNS ++D DS G TL+M+AA G D +R L+ +GA +N +++
Sbjct: 19 AARRGNLALLKLLLNSGR-VDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 633 NGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
+GTTAL AA++ V L GA + +G TAL+ A + G+ +V +++ GA+
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
Query: 693 CNILSKHQNSALHFAKQSNNVLVYDLL 719
+ +AL A Q + V LL
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLL 164
Score = 75.5 bits (184), Expect = 2e-13
Identities = 45/127 (35%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 593 NLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI 652
N+ + G T + LAA GG D++RLL+ GAKVN +++GT L A++ V +
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
Query: 653 LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNN 712
+L GA + +++G TAL+KA +G +D+++ +++ IL K+ SALH A S N
Sbjct: 197 MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGN 255
Query: 713 VLVYDLL 719
+ LL
Sbjct: 256 IKTVALL 262
Score = 67.4 bits (163), Expect = 5e-11
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Query: 563 DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLIT 622
D+ + +L A G V+ + + NL +E SG T + AA G +D++R L
Sbjct: 43 DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE--SGTTALFFAAQQGHNDVVRFLFG 100
Query: 623 KGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDI 682
GA R K+G TAL+ A++ + V LL+ GA ++ Q +G TAL A + G D+
Sbjct: 101 FGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDV 160
Query: 683 VRLVIECGADCNILSKHQNSALHFAKQ 709
+RL++ GA N + + L A Q
Sbjct: 161 IRLLLASGAKVNQPRQDGTAPLWIASQ 187
Score = 62.8 bits (151), Expect = 1e-09
Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 1/116 (0%)
Query: 608 AAAGGQDDLLRLLITKG-AKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSN 666
AA G LL+LL+ G V+ R +GTT L+ AA + V L+ GA +N+Q+ +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 667 GETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
G TAL A ++G++D+VR + GA +K +AL A Q ++ V + L H
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/121 (30%), Positives = 67/121 (55%), Gaps = 1/121 (0%)
Query: 601 GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV 660
G T ++ A+ G ++ L+ GA ++ + +G TAL AA+ +L + +LL +GA V
Sbjct: 112 GGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKV 171
Query: 661 NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSA-LHFAKQSNNVLVYDLL 719
N + +G L A + G+S++VR+++ GAD + +A L A + N ++ +LL
Sbjct: 172 NQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL 231
Query: 720 K 720
K
Sbjct: 232 K 232
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/92 (34%), Positives = 50/92 (54%), Gaps = 4/92 (4%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D + G T ++ AA G +D+++ L+ K + G KNGT+AL A + TVA+LL
Sbjct: 205 DAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIKTVALLL 263
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLV 686
EAGA +++ E + A N I+RL+
Sbjct: 264 EAGADPSLRNKANE---LPAELTKNERILRLL 292
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 75.1 bits (183), Expect = 3e-13
Identities = 95/422 (22%), Positives = 174/422 (41%), Gaps = 44/422 (10%)
Query: 112 ENKAKAVRKDIQRLSLNNDIFEANSDSDQQSET----KEDTSPKKKKKKLRQREEKSPDD 167
+NK K Q L L + +E DS Q+S+ + D S + K K L K D
Sbjct: 639 KNKEKGQCSISQELKLKSFTYEYE-DSKQKSDKAILLENDLSTENKLKVL-----KHDRD 692
Query: 168 LKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEA------------KEELKESKK 215
KK+ K K+K + K L +SL T K IS + KE + K
Sbjct: 693 HFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKS 752
Query: 216 PKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFV----ESQVESESSVLND 271
PK+++++ KE +K KK + R K + + D KE++ +K+++ + + +++ E D
Sbjct: 753 PKEEKLRLYKEERK-KKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYRED 811
Query: 272 SPFPE--------DDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEED 323
S F E ++ + S S +++ S + D E ++ P+ + D
Sbjct: 812 SAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSD 871
Query: 324 TDVR---GRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMP 380
+ + K+ + + D+R K + + F KK +N ++ K E K +P
Sbjct: 872 SVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVP 931
Query: 381 VSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKT 440
+R E G D+ E KE R + + K ++ H + +E G + K+
Sbjct: 932 GYLSEKDKKRRESAEAGRDRKDALESCKE--RRDGRAKPEEAHREELKECGCESGFKDKS 989
Query: 441 LKEIRNAFDLFK----LTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNT 496
+ + ++ +EK D + RK + P +K K K K L++ +
Sbjct: 990 DGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKD 1049
Query: 497 RD 498
++
Sbjct: 1050 KE 1051
Score = 64.7 bits (156), Expect = 4e-10
Identities = 102/473 (21%), Positives = 195/473 (41%), Gaps = 94/473 (19%)
Query: 79 RWKGYTSD-------DDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDI 131
RW SD +D+W+ + ++R +++ AK + + ++ S
Sbjct: 840 RWFSDLSDSSFDFKGEDSWDSPV---------TDYRDMKSDSVAKLILETVKEDSKER-- 888
Query: 132 FEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLE 191
+S + ++ + +E KK + L + EK + +K K+ G L +K K ES+
Sbjct: 889 -RRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEA 947
Query: 192 SLVFDLRTKKRISEAKEELKESK-KPKKDEVKETKE------LKKVKKGEI--------- 235
R +K E+ +E ++ + KP++ +E KE K G+
Sbjct: 948 G-----RDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWER 1002
Query: 236 ----RDLKTKTREDPKENRKTKKEKFVESQVE---SESSVLN----DSPFPEDDSEGLHS 284
R+ + K D + KTK E++ E + SE S+L D F + E +
Sbjct: 1003 HHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDT 1062
Query: 285 DSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMS---AEEDTDVRGRRKKKT-----PR 336
+ + + K +A D G E EK +S +E+ D +G+ K
Sbjct: 1063 KEKHKDTHGKDKERKASLDQGKEKK-EKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTD 1121
Query: 337 KAEDTRENRKLEN----------KNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTP 386
++ED R++ + L++K ++ DR + +++ + + P
Sbjct: 1122 ESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEP 1181
Query: 387 KGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRN 446
+ RR ++RG + D+ + KE + KEK K +S ++ K RK+ + + ++ +N
Sbjct: 1182 RDRR---KDRG--AADAGRDKKEKVFEKHKEKKDK--ESTEKYKDRKDRASVDSTQDKKN 1234
Query: 447 AFDLFKLTPE--EKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTR 497
L PE EK +E+ K + HK K +K+ KER+++R
Sbjct: 1235 KQKL----PEKAEKKHAAEDKAKSK-----------HKEKSDKEHSKERKSSR 1272
Score = 58.5 bits (140), Expect = 3e-08
Identities = 122/548 (22%), Positives = 211/548 (38%), Gaps = 83/548 (15%)
Query: 28 EEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILD-MKTEGGKVLYKVRWKGYTSD 86
E + V+ D D + + E+ E +F+ EK L +K + R + S+
Sbjct: 681 ENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSN 740
Query: 87 DDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKE 146
E + + KE L K E + K + +L ND+ E +++ KE
Sbjct: 741 KAEKERSLKEKSPKEEKLRLYK---EERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKE 797
Query: 147 DTSPKKKKKKLRQ--------REEKSPDDLKKKKAKAGKLKDKSKPDL---------ESS 189
D KK+K R+ + + ++ K + + +D+ DL E S
Sbjct: 798 DKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDS 857
Query: 190 LESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEI------RDLKTKTR 243
+S V D R K S AK L+ K+ K+ ++++ +K E RD K
Sbjct: 858 WDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS 917
Query: 244 EDPKENRKTKKEKFVESQVESESSVLNDSPFP-EDDSEGLHS--DSREEKQNTKSARERA 300
E KE +T+K K V + + +S D + L S + R+ + + A
Sbjct: 918 EKRKE--QTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREE 975
Query: 301 GQDMGLEHGFEKPLDSAMSA-----EEDTDVRGRRKKKTPRKA--EDTRENRKLENKNAF 353
++ G E GF+ D E R + KK P K E T+ R E +
Sbjct: 976 LKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDK 1035
Query: 354 --LEKKTVPKKQRNQDRSKSAAELEKLMPVSAQT---PKGRRLS---GEER------GLW 399
EK + K Q++++ K E + T K R+ S G+E+ G+
Sbjct: 1036 DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGII 1095
Query: 400 STDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKE----------------PKGLKTLKE 443
S D +E+ K+ K+ + K Y +D+ E R GL+ +E
Sbjct: 1096 SEDFSEK-KDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEE 1154
Query: 444 IRNAF-------DLFKLTPEEKNDVSENNRKREEIPLDF------KTIDDHKTKENKQSL 490
R A+ K PE + D +R+++ D K + HK K++K+S
Sbjct: 1155 GREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKEST 1214
Query: 491 KERRNTRD 498
++ ++ +D
Sbjct: 1215 EKYKDRKD 1222
Score = 57.0 bits (136), Expect = 7e-08
Identities = 70/365 (19%), Positives = 138/365 (37%), Gaps = 46/365 (12%)
Query: 143 ETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKR 202
+ KE+ + R+ +K + +K K + KD+ D + VF+ +K+
Sbjct: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKK 1209
Query: 203 ISEAKEELKESK-----KPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKF 257
E+ E+ K+ K +D+ + K +K +K + K K++ K +++ KE+
Sbjct: 1210 DKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERK 1269
Query: 258 VESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSA 317
++E S+L + + E LH + + D G E G L+ +
Sbjct: 1270 SSRSADAEKSLLE-----KLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVS 1324
Query: 318 MSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEK 377
+ E D + R P K ++ +R + + KK +++R+K +K
Sbjct: 1325 FT-EPPGDDKPRESACLPEKLKEKERHRHSSSSS---------KKSHDRERAKKEKAEKK 1374
Query: 378 LMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKG 437
+ E+ KE + +Y+K + + G
Sbjct: 1375 ------------------------EKGEDYKEGGSRKDSGQYEKDF-LEADAYGVSYNMK 1409
Query: 438 LKTLKEIRNAFDLFKLTPEEKNDVS-ENNRKREEIPLDFKTIDDHKTKENKQSLKERRNT 496
E+ +LF ++KND E ++K E+ + + + KE K+ K R
Sbjct: 1410 ADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKW 1469
Query: 497 RDETD 501
RDE +
Sbjct: 1470 RDEKE 1474
Score = 55.8 bits (133), Expect = 2e-07
Identities = 94/468 (20%), Positives = 181/468 (38%), Gaps = 74/468 (15%)
Query: 136 SDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVF 195
S+SD SE S K +K+ R+ S L +K P L SS E V
Sbjct: 575 SESDYSSEGSSVESLKPVRKRQEHRKRAS-------------LSEKKSPFL-SSAEGAVP 620
Query: 196 DLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKE 255
L + ++ + + + K +K + ++ELK LK+ T E +K+ K
Sbjct: 621 KLDKEGKVVKKHKTKHKHKNKEKGQCSISQELK---------LKSFTYEYEDSKQKSDKA 671
Query: 256 KFVESQVESESS--VLNDSPFPEDDSEGLHSDSREEKQ----NTKSARERAGQDMGLEHG 309
+E+ + +E+ VL E L EEK+ + KS + + +
Sbjct: 672 ILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRS 731
Query: 310 FEKPLDSAMSAEEDTDVRGRRKK-------KTPRKAEDTRENRKLENKNAFLEKKTVPKK 362
F + D + AE++ ++ + K K RK + KLE KN E K +K
Sbjct: 732 FREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEK 791
Query: 363 QRNQDRSKSAAELEKLMPVSAQTPKGRR-------------LSGEERGLWSTDSAEEDKE 409
++ K + EK+ + + LS ++R W +D ++ +
Sbjct: 792 EKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFD 851
Query: 410 TKRNESKEK-----YQKRHDS---------DKEEKGRKEPKGLKTLKEIRNAFDLFKLTP 455
K +S + + DS ++ K R+ + ++ R F
Sbjct: 852 FKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPF----FRK 907
Query: 456 EEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVL 515
++++ + +N+ KR+E K++ + ++++K+ + RD D A E +E
Sbjct: 908 KDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKD-----ALESCKERR 962
Query: 516 DSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATD 563
D + +E R+++ G + + DF K L+ + + A +
Sbjct: 963 DGRAKPEEAH--REELKECGCESGFKDKSDGDFGKGLEPWERHHPARE 1008
Score = 55.1 bits (131), Expect = 3e-07
Identities = 33/94 (35%), Positives = 48/94 (51%)
Query: 626 KVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRL 685
KVN R + G T L AA + + L+ GA VNV+ G TAL +AC RG D+ +
Sbjct: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
Query: 686 VIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
++ GA+ N ++ LH A + + V LL
Sbjct: 220 LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLL 253
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/105 (29%), Positives = 53/105 (50%)
Query: 588 SNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFL 647
S + +++ + G T + AA G ++ LI++GA VN + G TAL A + +
Sbjct: 155 SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214
Query: 648 TTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
LL AGA VN + + +T L A G+ +V+L++ G +
Sbjct: 215 DVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGN 259
Score = 48.9 bits (115), Expect = 2e-05
Identities = 95/366 (25%), Positives = 144/366 (39%), Gaps = 49/366 (13%)
Query: 139 DQQSETKEDTS---PKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVF 195
D + ETK ++ PK + K + +P KKA L D S D E + S+
Sbjct: 370 DYRKETKSNSFISIPKMEVKSYTKNNTIAP-----KKASHRILSDTS--DEEDA--SVTV 420
Query: 196 DLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKE 255
K R+S A L SK + K+ KE KVKK R +TK RE R +
Sbjct: 421 GTGEKLRLS-AHTILPGSKTREPSNAKQQKEKNKVKKK--RKKETKGREVRFGKRS---D 474
Query: 256 KFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLD 315
KF S+ ESESS EDD + L S +D L F
Sbjct: 475 KFCSSESESESSESG-----EDDRDSLGS------SGCLKGSPLVLKDPSL---FSSLSA 520
Query: 316 SAMSAEEDTDVRGRRKKKTPRKAEDTR-ENRKLENKNAFLEKKTVPKKQRNQ-----DRS 369
S+ S+ + + + T + + R +N K + A+ E ++ R + D S
Sbjct: 521 SSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYS 580
Query: 370 KSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAE--EDKETKRNESKEKYQKRHDSDK 427
+ +E L PV + +R S E+ SAE K K + +K++ +H
Sbjct: 581 SEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKN 640
Query: 428 EEKGRKEPKGLKTLKEIRNAFDLFKLTPEE----KNDVSENNRKREEIPLDFKTIDDHKT 483
+EKG+ LK ++ K ++ +ND+S N+ + K DH
Sbjct: 641 KEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKV-----LKHDRDHFK 695
Query: 484 KENKQS 489
KE K S
Sbjct: 696 KEEKLS 701
Score = 47.4 bits (111), Expect = 6e-05
Identities = 108/528 (20%), Positives = 202/528 (38%), Gaps = 72/528 (13%)
Query: 83 YTSDDDTWEPEIHLEDCKEVLL-EFRKKIAENKAKAVRK-DIQRLSLNNDIFEANSDSDQ 140
Y D+D + + D K +L ++RK+ N ++ K +++ + NN I +
Sbjct: 347 YEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRI 406
Query: 141 QSETKED-----TSPKKKKKKLRQR------EEKSPDDLKKKKAKAGKLKDKSKPDLESS 189
S+T ++ T +K +L + + P + K++K K K+K K K + +
Sbjct: 407 LSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEK-NKVKKKRKKETKG- 464
Query: 190 LESLVFDLRTKKRIS-EAKEELKESKKPKKDEVKETKELK---------------KVKKG 233
+ F R+ K S E++ E ES + +D + + LK
Sbjct: 465 -REVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASST 523
Query: 234 EIRDLKTKTREDPK------ENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSR 287
+++P ++ +T K + S SE S L+DS SE +S
Sbjct: 524 SSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEG 583
Query: 288 EEKQNTKSARERAGQDMGLEHGFEKP--LDSAMSAEEDTDVRGR--RKKKTPRKAEDTRE 343
++ K R+R +K L SA A D G+ +K KT K ++ +
Sbjct: 584 SSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEK 643
Query: 344 NRKLENKNAFLEKKTVPKKQRNQDRSKSAA---------ELEKLMPVSAQTPKGRRLSG- 393
+ ++ L+ T + Q K+ +L+ L K +LS
Sbjct: 644 GQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKM 703
Query: 394 ---EERGLWSTD-SAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFD 449
E+ L+ + S + K+T ++ S+ +++ S+K EK R +LKE
Sbjct: 704 KLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKER-------SLKE------ 750
Query: 450 LFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAAE 509
K EEK + + RK++ K + KE+K S ++ + +++ +
Sbjct: 751 --KSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVY 808
Query: 510 GDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMK-LEDFQKHLDGKD 556
+ D C ++ + SL D + W L D G+D
Sbjct: 809 REDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGED 856
Score = 41.2 bits (95), Expect = 0.004
Identities = 99/515 (19%), Positives = 191/515 (37%), Gaps = 114/515 (22%)
Query: 108 KKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDD 167
K ++K K ++ ++ D A+ DS Q + K+ K +KK + + KS
Sbjct: 1200 KVFEKHKEKKDKESTEKYKDRKD--RASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK 1257
Query: 168 LKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEV------ 221
K K + + K D E SL +K EA E +E K EV
Sbjct: 1258 EKSDKEHSKERKSSRSADAEKSL--------LEKLEEEALHEYREDSNDKISEVSSDSFT 1309
Query: 222 --------------------------------KETKELKKVKKGEIRDLKTKTREDPKEN 249
++ KE ++ + K+ RE K+
Sbjct: 1310 DRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKE 1369
Query: 250 RKTKKEK---FVESQVESESSVLNDSPFPEDDSEGLHSD----------------SREEK 290
+ KKEK + E +S + F E D+ G+ + S E+K
Sbjct: 1370 KAEKKEKGEDYKEGGSRKDSGQY-EKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKK 1428
Query: 291 QNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRE------- 343
S RE + + +E + SA++ ++ R + ++K + E R+
Sbjct: 1429 DKNDSEREPSKK---IEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLL 1485
Query: 344 ---------NRKLENKNAFLEKKTVPK----KQRNQDRSKSAAELEKLMPVSAQTPKG-- 388
+ + E K A +K + P+ K R++ A+L++ A+ KG
Sbjct: 1486 RHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDP 1545
Query: 389 -RRLSGEERGLWSTDSAEEDKETKRN---------ESKEKYQKRHDSDKEEKGRKEPKGL 438
+ +G ++ S D ++D + S E+ + D + EE+ ++ + +
Sbjct: 1546 VKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERM 1605
Query: 439 KTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIP------LDFKTIDDHKTKEN---KQS 489
K ++++R+ KL E+ + +K +IP LD D K KE+ +
Sbjct: 1606 KQMEKLRHRSGDPKL-KEKAKPADDGRKKGLDIPAKKPPGLD-PPFKDKKLKESTPIPPA 1663
Query: 490 LKERRNTRDETDTWAYIAAEGDQEVLDSVCQADEN 524
+ + + D+ ++A +EVL + + D++
Sbjct: 1664 AENKLHPASGADSKDWLAGPHMKEVLPASPRPDQS 1698
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 74.3 bits (181), Expect = 4e-13
Identities = 51/141 (36%), Positives = 71/141 (50%), Gaps = 2/141 (1%)
Query: 567 SNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAK 626
SN + A ++G T+K S + LD +D SG + +AA G D+ +LL + G+
Sbjct: 413 SNAVYWAARHGHVDTLKFL--SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN 470
Query: 627 VNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLV 686
N + K T L AA + + L EAG VN++ GET L+ A RG DIV +
Sbjct: 471 PNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECL 530
Query: 687 IECGADCNILSKHQNSALHFA 707
E GAD N K + ALH A
Sbjct: 531 AEHGADLNACDKDGHIALHLA 551
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/152 (26%), Positives = 81/152 (53%)
Query: 556 DENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDD 615
D+ D+ + A+ + + ++ L S Y+++Q + G +++AA G
Sbjct: 334 DDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQ 393
Query: 616 LLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKAC 675
+L+LLI +G++++ + K G+ A+ AA + T+ L E ++V+ +GE AL A
Sbjct: 394 ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 676 KRGNSDIVRLVIECGADCNILSKHQNSALHFA 707
+ G++D+ +L+ G++ NI K + + LH A
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
Score = 65.9 bits (159), Expect = 2e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 593 NLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI 652
N++ ++ G T ++ A+A G D++ L GA +N K+G AL A + + +
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 653 LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNN 712
LL G FV+ Q +G T L ACK GN IV + E + +I +K+ + LH A +N
Sbjct: 563 LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA-ANNG 621
Query: 713 VL 714
+L
Sbjct: 622 IL 623
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 74.3 bits (181), Expect = 4e-13
Identities = 50/153 (32%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K G K+ L D +G+T + +AA + LL+ KGA +
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAA--ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
KNG T L AA+KN + + LL GA N+ G T L A + G++D+V L+++
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ ++ +K ++LH A Q + V V D+L H
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K LN E N+ + G+T + LA+ G D++ LL+ KGA ++
Sbjct: 612 LHIAAKKNQMQIASTLLNYGAETNIVTKQ--GVTPLHLASQEGHTDMVTLLLDKGANIHM 669
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
K+G T+L AA+++ + IL + GA + G T L+ AC GN +V +++
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ N +K+ + LH A Q + + ++L H
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Score = 67.4 bits (163), Expect = 5e-11
Identities = 45/140 (32%), Positives = 73/140 (52%)
Query: 581 TVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIH 640
T V L ++ N+ SG+T + LAA + ++ +L GA + K G T LI
Sbjct: 654 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 713
Query: 641 AAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQ 700
A + V LL+ GA VN + NG T L +A ++G++ I+ ++++ GA N + +
Sbjct: 714 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Query: 701 NSALHFAKQSNNVLVYDLLK 720
N+AL AK+ + V D LK
Sbjct: 774 NTALAIAKRLGYISVVDTLK 793
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 3/170 (1%)
Query: 602 MTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVN 661
+T + +AA G + +LL+ K A N R NG T L A +KN + + +L++ GA +
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404
Query: 662 VQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV-LVYDLLK 720
+G T + A G+ +IV L+++ GA ++ + +ALH A ++ V +V LL+
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
Query: 721 NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKP 770
N +R EE + +RL E V + H PD +T Y P
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATTNGYTP 512
Score = 63.5 bits (153), Expect = 8e-10
Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 568 NVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKV 627
N L A K G V+ L ++D G T + +A+ GQ +++++L+ +GA +
Sbjct: 45 NALHLAAKEGHVGLVQELLGRGS--SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 628 NGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVI 687
N + +NG T L AA++N + V LLE GA + +G T L A ++G++ V +++
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Query: 688 ECGADCNILSKHQNSALHFAKQSNN 712
E + K + ALH A + ++
Sbjct: 163 E----NDTKGKVRLPALHIAARKDD 183
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/168 (29%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 581 TVKVALNSNEEYNLDQEDS--------SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQK 632
T AL ++N D + SG T + +AA G ++ LL+ +GA V+ +
Sbjct: 184 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 243
Query: 633 NGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
NG T L A+++ V +LL+ G ++ + +G T L A + G+ +V L++E GA
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 693 CNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEA 740
+K+ S LH A Q ++V + +K+ L+ + V + T+ DY A
Sbjct: 304 LLARTKNGLSPLHMAAQGDHV---ECVKHLLQHKAPVDDVTL-DYLTA 347
Score = 62.4 bits (150), Expect = 2e-09
Identities = 48/166 (28%), Positives = 76/166 (45%), Gaps = 5/166 (3%)
Query: 557 ENFAATDAIPSN---VLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
++ A DA +N L + + G V L + ++L + G T + +AA G
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGS 554
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D+ +LL+ + A + KNG T L AA + +LLE GA + NG T L
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 614
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
A K+ I ++ GA+ NI++K + LH A Q + + LL
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 2/154 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A G Y K+ L+ N + +G T + +A + ++ LL+ GA +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRA--NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
++G T + AA L V +LL+ GA +V GETAL A + G ++VR ++
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNHL 723
GA + ++ + + LH A + + LL H+
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Score = 61.2 bits (147), Expect = 4e-09
Identities = 50/178 (28%), Positives = 89/178 (50%), Gaps = 4/178 (2%)
Query: 554 GKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
G +F A + I L A K G+ VK+ L+ + +D + G+T + AA G
Sbjct: 235 GAAVDFTARNGITP--LHVASKRGNTNMVKLLLDRGGQ--IDAKTRDGLTPLHCAARSGH 290
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D ++ LL+ +GA + R KNG + L AA+ + + V LL+ A V+ + TAL
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAE 731
A G+ + +L+++ A+ N + + + LH A + N + V +LL + ++ + E
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408
Score = 59.3 bits (142), Expect = 1e-08
Identities = 39/125 (31%), Positives = 68/125 (54%), Gaps = 1/125 (0%)
Query: 598 DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAG 657
+ +G+ + LAA G L++ L+ +G+ V+ K G TAL A+ V +L++ G
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
Query: 658 AFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA-KQSNNVLVY 716
A +N Q NG T L A + + D+V+ ++E GA+ + ++ + L A +Q +N V
Sbjct: 100 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 717 DLLKN 721
LL+N
Sbjct: 160 ILLEN 164
Score = 55.1 bits (131), Expect = 3e-07
Identities = 42/149 (28%), Positives = 75/149 (50%), Gaps = 4/149 (2%)
Query: 596 QEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLE 655
Q+ S + + A AG D ++ L G +N +NG AL AA++ + V LL
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 656 AGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLV 715
G+ V+ G TAL A G +++V+++++ GA+ N S++ + L+ A Q N++
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI-- 122
Query: 716 YDLLKNHLETLSRVAEETIKDYFEARLAL 744
D++K LE + + T + +AL
Sbjct: 123 -DVVKYLLENGANQSTATEDGFTPLAVAL 150
Score = 53.9 bits (128), Expect = 6e-07
Identities = 36/125 (28%), Positives = 63/125 (50%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D + G T + +AA GQ +++R L+ GA V+ R + T L A+ V +LL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + +NG T L + + G D+ +++E GA ++ +K + LH A + ++
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556
Query: 715 VYDLL 719
V LL
Sbjct: 557 VAKLL 561
Score = 53.5 bits (127), Expect = 8e-07
Identities = 37/128 (28%), Positives = 61/128 (47%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D ++G T + ++A GQ D+ +L+ GA + K G T L AA+ L +LL
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + NG T L A N + L++E GA + +K+ + LH A + N +
Sbjct: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622
Query: 715 VYDLLKNH 722
+ L N+
Sbjct: 623 IASTLLNY 630
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/126 (27%), Positives = 63/126 (50%)
Query: 594 LDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAIL 653
+D T + +A+ G+ ++++LL+ A + NG T L +A + + ++L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Query: 654 LEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
LEAGA ++ G T L A K G+ D+ +L+++ A + K+ + LH A +N
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
Query: 714 LVYDLL 719
V LL
Sbjct: 589 KVALLL 594
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/120 (29%), Positives = 61/120 (50%)
Query: 600 SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF 659
SG+T + +AA G +++ LL+ GA + G TAL AA + V LL GA
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468
Query: 660 VNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
V+ + +T L A + G ++IV+L+++ A + + + + LH + + V V +L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Score = 33.5 bits (75), Expect = 0.87
Identities = 19/59 (32%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 662 VQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV-LVYDLL 719
+Q+S+ + ++A + GN D V ++ G D N +++ +ALH A + +V LV +LL
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 74.3 bits (181), Expect = 4e-13
Identities = 50/153 (32%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K G K+ L D +G+T + +AA + LL+ KGA +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAA--ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
KNG T L AA+KN + + LL GA N+ G T L A + G++D+V L+++
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ ++ +K ++LH A Q + V V D+L H
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K LN E N+ + G+T + LA+ G D++ LL+ KGA ++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQ--GVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
K+G T+L AA+++ + IL + GA + G T L+ AC GN +V +++
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ N +K+ + LH A Q + + ++L H
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 67.4 bits (163), Expect = 5e-11
Identities = 45/140 (32%), Positives = 73/140 (52%)
Query: 581 TVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIH 640
T V L ++ N+ SG+T + LAA + ++ +L GA + K G T LI
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Query: 641 AAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQ 700
A + V LL+ GA VN + NG T L +A ++G++ I+ ++++ GA N + +
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 701 NSALHFAKQSNNVLVYDLLK 720
N+AL AK+ + V D LK
Sbjct: 795 NTALAIAKRLGYISVVDTLK 814
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 3/170 (1%)
Query: 602 MTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVN 661
+T + +AA G + +LL+ K A N R NG T L A +KN + + +L++ GA +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 662 VQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV-LVYDLLK 720
+G T + A G+ +IV L+++ GA ++ + +ALH A ++ V +V LL+
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Query: 721 NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKP 770
N +R EE + +RL E V + H PD +T Y P
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATTNGYTP 533
Score = 63.5 bits (153), Expect = 8e-10
Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 568 NVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKV 627
N L A K G V+ L ++D G T + +A+ GQ +++++L+ +GA +
Sbjct: 66 NALHLAAKEGHVGLVQELLGRGS--SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 628 NGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVI 687
N + +NG T L AA++N + V LLE GA + +G T L A ++G++ V +++
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 688 ECGADCNILSKHQNSALHFAKQSNN 712
E + K + ALH A + ++
Sbjct: 184 E----NDTKGKVRLPALHIAARKDD 204
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/168 (29%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 581 TVKVALNSNEEYNLDQEDS--------SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQK 632
T AL ++N D + SG T + +AA G ++ LL+ +GA V+ +
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264
Query: 633 NGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
NG T L A+++ V +LL+ G ++ + +G T L A + G+ +V L++E GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 693 CNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEA 740
+K+ S LH A Q ++V + +K+ L+ + V + T+ DY A
Sbjct: 325 LLARTKNGLSPLHMAAQGDHV---ECVKHLLQHKAPVDDVTL-DYLTA 368
Score = 62.4 bits (150), Expect = 2e-09
Identities = 48/166 (28%), Positives = 76/166 (45%), Gaps = 5/166 (3%)
Query: 557 ENFAATDAIPSN---VLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
++ A DA +N L + + G V L + ++L + G T + +AA G
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGS 575
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D+ +LL+ + A + KNG T L AA + +LLE GA + NG T L
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
A K+ I ++ GA+ NI++K + LH A Q + + LL
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 2/154 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A G Y K+ L+ N + +G T + +A + ++ LL+ GA +
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRA--NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
++G T + AA L V +LL+ GA +V GETAL A + G ++VR ++
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNHL 723
GA + ++ + + LH A + + LL H+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 61.2 bits (147), Expect = 4e-09
Identities = 50/178 (28%), Positives = 89/178 (50%), Gaps = 4/178 (2%)
Query: 554 GKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
G +F A + I L A K G+ VK+ L+ + +D + G+T + AA G
Sbjct: 256 GAAVDFTARNGITP--LHVASKRGNTNMVKLLLDRGGQ--IDAKTRDGLTPLHCAARSGH 311
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D ++ LL+ +GA + R KNG + L AA+ + + V LL+ A V+ + TAL
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAE 731
A G+ + +L+++ A+ N + + + LH A + N + V +LL + ++ + E
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Score = 59.3 bits (142), Expect = 1e-08
Identities = 39/125 (31%), Positives = 68/125 (54%), Gaps = 1/125 (0%)
Query: 598 DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAG 657
+ +G+ + LAA G L++ L+ +G+ V+ K G TAL A+ V +L++ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 658 AFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA-KQSNNVLVY 716
A +N Q NG T L A + + D+V+ ++E GA+ + ++ + L A +Q +N V
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 717 DLLKN 721
LL+N
Sbjct: 181 ILLEN 185
Score = 54.3 bits (129), Expect = 5e-07
Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 4/157 (2%)
Query: 588 SNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFL 647
S++ ++ S + + A AG D ++ L G +N +NG AL AA++ +
Sbjct: 19 SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHV 77
Query: 648 TTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA 707
V LL G+ V+ G TAL A G +++V+++++ GA+ N S++ + L+ A
Sbjct: 78 GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 708 KQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLAL 744
Q N++ D++K LE + + T + +AL
Sbjct: 138 AQENHI---DVVKYLLENGANQSTATEDGFTPLAVAL 171
Score = 53.9 bits (128), Expect = 6e-07
Identities = 36/125 (28%), Positives = 63/125 (50%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D + G T + +AA GQ +++R L+ GA V+ R + T L A+ V +LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + +NG T L + + G D+ +++E GA ++ +K + LH A + ++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 715 VYDLL 719
V LL
Sbjct: 578 VAKLL 582
Score = 53.5 bits (127), Expect = 8e-07
Identities = 37/128 (28%), Positives = 61/128 (47%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D ++G T + ++A GQ D+ +L+ GA + K G T L AA+ L +LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + NG T L A N + L++E GA + +K+ + LH A + N +
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 715 VYDLLKNH 722
+ L N+
Sbjct: 644 IASTLLNY 651
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/126 (27%), Positives = 63/126 (50%)
Query: 594 LDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAIL 653
+D T + +A+ G+ ++++LL+ A + NG T L +A + + ++L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 654 LEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
LEAGA ++ G T L A K G+ D+ +L+++ A + K+ + LH A +N
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 714 LVYDLL 719
V LL
Sbjct: 610 KVALLL 615
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/120 (29%), Positives = 61/120 (50%)
Query: 600 SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF 659
SG+T + +AA G +++ LL+ GA + G TAL AA + V LL GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 660 VNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
V+ + +T L A + G ++IV+L+++ A + + + + LH + + V V +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 74.3 bits (181), Expect = 4e-13
Identities = 50/153 (32%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K G K+ L D +G+T + +AA + LL+ KGA +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAA--ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
KNG T L AA+KN + + LL GA N+ G T L A + G++D+V L+++
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ ++ +K ++LH A Q + V V D+L H
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 2/153 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A K LN E N+ + G+T + LA+ G D++ LL+ KGA ++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQ--GVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
K+G T+L AA+++ + IL + GA + G T L+ AC GN +V +++
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNH 722
GA+ N +K+ + LH A Q + + ++L H
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 67.4 bits (163), Expect = 5e-11
Identities = 45/140 (32%), Positives = 73/140 (52%)
Query: 581 TVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIH 640
T V L ++ N+ SG+T + LAA + ++ +L GA + K G T LI
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Query: 641 AAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQ 700
A + V LL+ GA VN + NG T L +A ++G++ I+ ++++ GA N + +
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 701 NSALHFAKQSNNVLVYDLLK 720
N+AL AK+ + V D LK
Sbjct: 795 NTALAIAKRLGYISVVDTLK 814
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 3/170 (1%)
Query: 602 MTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVN 661
+T + +AA G + +LL+ K A N R NG T L A +KN + + +L++ GA +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 662 VQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV-LVYDLLK 720
+G T + A G+ +IV L+++ GA ++ + +ALH A ++ V +V LL+
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Query: 721 NHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKP 770
N +R EE + +RL E V + H PD +T Y P
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATTNGYTP 533
Score = 63.5 bits (153), Expect = 8e-10
Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 6/145 (4%)
Query: 568 NVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKV 627
N L A K G V+ L ++D G T + +A+ GQ +++++L+ +GA +
Sbjct: 66 NALHLAAKEGHVGLVQELLGRGS--SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 628 NGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVI 687
N + +NG T L AA++N + V LLE GA + +G T L A ++G++ V +++
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 688 ECGADCNILSKHQNSALHFAKQSNN 712
E + K + ALH A + ++
Sbjct: 184 E----NDTKGKVRLPALHIAARKDD 204
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/168 (29%), Positives = 85/168 (50%), Gaps = 12/168 (7%)
Query: 581 TVKVALNSNEEYNLDQEDS--------SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQK 632
T AL ++N D + SG T + +AA G ++ LL+ +GA V+ +
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264
Query: 633 NGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGAD 692
NG T L A+++ V +LL+ G ++ + +G T L A + G+ +V L++E GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 693 CNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEA 740
+K+ S LH A Q ++V + +K+ L+ + V + T+ DY A
Sbjct: 325 LLARTKNGLSPLHMAAQGDHV---ECVKHLLQHKAPVDDVTL-DYLTA 368
Score = 62.4 bits (150), Expect = 2e-09
Identities = 48/166 (28%), Positives = 76/166 (45%), Gaps = 5/166 (3%)
Query: 557 ENFAATDAIPSN---VLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
++ A DA +N L + + G V L + ++L + G T + +AA G
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGS 575
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D+ +LL+ + A + KNG T L AA + +LLE GA + NG T L
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
A K+ I ++ GA+ NI++K + LH A Q + + LL
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 2/154 (1%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A G Y K+ L+ N + +G T + +A + ++ LL+ GA +
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRA--NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
++G T + AA L V +LL+ GA +V GETAL A + G ++VR ++
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNHL 723
GA + ++ + + LH A + + LL H+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 61.2 bits (147), Expect = 4e-09
Identities = 50/178 (28%), Positives = 89/178 (50%), Gaps = 4/178 (2%)
Query: 554 GKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
G +F A + I L A K G+ VK+ L+ + +D + G+T + AA G
Sbjct: 256 GAAVDFTARNGITP--LHVASKRGNTNMVKLLLDRGGQ--IDAKTRDGLTPLHCAARSGH 311
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
D ++ LL+ +GA + R KNG + L AA+ + + V LL+ A V+ + TAL
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAE 731
A G+ + +L+++ A+ N + + + LH A + N + V +LL + ++ + E
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Score = 59.3 bits (142), Expect = 1e-08
Identities = 39/125 (31%), Positives = 68/125 (54%), Gaps = 1/125 (0%)
Query: 598 DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAG 657
+ +G+ + LAA G L++ L+ +G+ V+ K G TAL A+ V +L++ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 658 AFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA-KQSNNVLVY 716
A +N Q NG T L A + + D+V+ ++E GA+ + ++ + L A +Q +N V
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 717 DLLKN 721
LL+N
Sbjct: 181 ILLEN 185
Score = 54.3 bits (129), Expect = 5e-07
Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 4/157 (2%)
Query: 588 SNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFL 647
S++ ++ S + + A AG D ++ L G +N +NG AL AA++ +
Sbjct: 19 SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHV 77
Query: 648 TTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA 707
V LL G+ V+ G TAL A G +++V+++++ GA+ N S++ + L+ A
Sbjct: 78 GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 708 KQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLAL 744
Q N++ D++K LE + + T + +AL
Sbjct: 138 AQENHI---DVVKYLLENGANQSTATEDGFTPLAVAL 171
Score = 53.9 bits (128), Expect = 6e-07
Identities = 36/125 (28%), Positives = 63/125 (50%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D + G T + +AA GQ +++R L+ GA V+ R + T L A+ V +LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + +NG T L + + G D+ +++E GA ++ +K + LH A + ++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 715 VYDLL 719
V LL
Sbjct: 578 VAKLL 582
Score = 53.5 bits (127), Expect = 8e-07
Identities = 37/128 (28%), Positives = 61/128 (47%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D ++G T + ++A GQ D+ +L+ GA + K G T L AA+ L +LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
+ A + NG T L A N + L++E GA + +K+ + LH A + N +
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 715 VYDLLKNH 722
+ L N+
Sbjct: 644 IASTLLNY 651
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/126 (27%), Positives = 63/126 (50%)
Query: 594 LDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAIL 653
+D T + +A+ G+ ++++LL+ A + NG T L +A + + ++L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 654 LEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
LEAGA ++ G T L A K G+ D+ +L+++ A + K+ + LH A +N
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 714 LVYDLL 719
V LL
Sbjct: 610 KVALLL 615
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/120 (29%), Positives = 61/120 (50%)
Query: 600 SGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF 659
SG+T + +AA G +++ LL+ GA + G TAL AA + V LL GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 660 VNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
V+ + +T L A + G ++IV+L+++ A + + + + LH + + V V +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 34.7 bits (78), Expect = 0.39
Identities = 77/398 (19%), Positives = 146/398 (36%), Gaps = 48/398 (12%)
Query: 142 SETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLK-----DKSKPDLESSLESLVFD 196
SE +E T+ + K L E D + G ++ + + P +S + S V D
Sbjct: 2367 SEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVAD 2426
Query: 197 ---LRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTK 253
+ K EA L+++ K + E LK+ RD + +PK
Sbjct: 2427 DSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKE---SPCRDSLESSPVEPKMKAGIF 2483
Query: 254 KEKFVESQVESESSVLND-----SPFPEDDSEGLHSDSREEKQNTKSARER-------AG 301
F +++ +L + S D DS E+ +S+ + +
Sbjct: 2484 PSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSS 2543
Query: 302 QDMGLEH-------GFEKPLDSAMSAEEDTDVRGRRKKKTPRKA--EDTRENRKLENKNA 352
+++ E KP AEED G +K+ TP + + + + +
Sbjct: 2544 EEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQ 2603
Query: 353 FLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKR 412
++K KK+ Q+ S S+++ + V PK +E G+ ++E K +
Sbjct: 2604 EAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSS 2663
Query: 413 NESK-EKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEI 471
+ES+ E Q + +D GL IR P ++N EE+
Sbjct: 2664 SESEPELAQLKKGAD---------SGLLPEPVIR------VQPPSPLPSSMDSNSSPEEV 2708
Query: 472 PLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAAE 509
+ K N+ + +E + +E D+ +++A +
Sbjct: 2709 QFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAED 2746
Score = 34.3 bits (77), Expect = 0.51
Identities = 68/349 (19%), Positives = 135/349 (38%), Gaps = 50/349 (14%)
Query: 118 VRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKK---------KKKKLRQREEKSPDDL 168
V++D++++ N+I + + + +S + S + +++ + +K+P ++
Sbjct: 1555 VKEDLEKV---NEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEI 1611
Query: 169 KKKKAKAGKL----KDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEV--- 221
+ ++ K K + D + L DL T + + + + + K KK E
Sbjct: 1612 TEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAV 1671
Query: 222 --KETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDS 279
KE K + E + + K + +K + K E Q + E
Sbjct: 1672 GRSSEKEGKDIPPDETQSTQ-KQHKPSLGIKKPVRRKLKEKQKQKE-------------- 1716
Query: 280 EGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAE---EDTDVRG-RRKKKTP 335
EGL + + + + S+ E G+D GL +PL + + E+T + + K K
Sbjct: 1717 EGLQASAEKAELKKGSSEESLGEDPGLA---PEPLPTVKATSPLIEETPIGSIKDKVKAL 1773
Query: 336 RKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAEL--EKLMPVSAQTPKGRRLSG 393
+K + + + + K+ VPKK ++ ++ L E+ P + +PK R S
Sbjct: 1774 QKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAP-GSPSPKTERHS- 1831
Query: 394 EERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLK 442
L S+ E + EK+ S K E+ KT K
Sbjct: 1832 ---TLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEK 1877
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 73.9 bits (180), Expect = 6e-13
Identities = 84/485 (17%), Positives = 207/485 (42%), Gaps = 52/485 (10%)
Query: 84 TSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDS----- 138
T ++ W E E L E KKI + + K R++ + + E
Sbjct: 231 TLQEEMWRQE-------EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK 283
Query: 139 ---DQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVF 195
+Q+ E +E +++KKLR++EE+ + +K + K++++ + E ++
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ--EERLW 341
Query: 196 DLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKE 255
+ + R E K +E + ++DE KE + ++ ++ + + K +E+ + + KK
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 256 KFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLD 315
+ E + + + ++++ + ++Q +E+ + ++ EK +
Sbjct: 402 REEEETMREQEEKMQK----QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457
Query: 316 SAMSAEEDTDVRGRRKKKTPRKAEDTRENR--KLENKNAFLEKKTVPKKQRNQDRSKSAA 373
+ ++ G+ KK ++ +E++ + E K E+K +++R ++ +
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 374 ELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRK 433
E E+ M E++ +W + +E R E K + Q++ D+EEK R+
Sbjct: 518 EKEERMR-------------EQKKMW------QQEEKMREEKKTQEQEKKTWDQEEKMRE 558
Query: 434 EPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKER 493
E + + K++R ++ + E+ + E R++EE + +E K +E
Sbjct: 559 EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE---------QEEKMQEQEE 609
Query: 494 RNTRDETDTWAYIAAEGDQEVLDSVCQADEN-SDGRQQILSLGMDLQLEWMKLEDFQKHL 552
+ E W + QE + + + +E + +++ ++ + K+ + ++ +
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKM 669
Query: 553 DGKDE 557
G++E
Sbjct: 670 QGQEE 674
Score = 72.8 bits (177), Expect = 1e-12
Identities = 80/441 (18%), Positives = 203/441 (46%), Gaps = 50/441 (11%)
Query: 100 KEVLLEFRKKIAENKAKAVRKDIQRLSLNND-----IFEANSDSDQQSETKEDTSPKKKK 154
K L+ + ++AE++ ++ +++ L + + + +++ Q+ +++ ++++
Sbjct: 188 KNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 247
Query: 155 KKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESK 214
KK+R++EEK ++ + + GK++++ E + R +KR+ E ++EL+E +
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMREQ-----EEKMR------RQEKRLREQEKELREQE 296
Query: 215 KPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQ--VESESSVLNDS 272
K E++E K+L++ ++ ++++ + K E ++ R+ +++ + + + E E +
Sbjct: 297 K----ELREQKKLRE-QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351
Query: 273 PFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKK 332
D E + ++ + RE+ EK + +E+ +R R KK
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQ-----------EKMWEQEEKMQEEERIREREKK 400
Query: 333 -----KTPRKAED----TRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSA 383
+T R+ E+ EN + + + +++ +K++ ++ K + EK+
Sbjct: 401 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 384 QTPKGRRLSGEERGLWSTDS-AEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLK 442
+ + G+E+ +W + E++ + E K + Q++ D+EE+ ++ + L+ K
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE-K 519
Query: 443 EIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDT 502
E R EEK + +++E+ KT D + ++ ++ER E +
Sbjct: 520 EERMREQKKMWQQEEKMREEKKTQEQEK-----KTWDQEEKMREEERMREREKKMREEEE 574
Query: 503 WAYIAAEGDQEVLDSVCQADE 523
E QE + + + +E
Sbjct: 575 MMREQEEKMQEQEEKMREQEE 595
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/505 (17%), Positives = 205/505 (40%), Gaps = 56/505 (11%)
Query: 27 VEEGVGVVGEDNDAAARGAEAFGDSE----EDGEDVFEVEKILDMKT---EGGKVLYKVR 79
+ E G + E + R + + E E +++ E +K+ + + E + +++
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 80 WKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSD 139
K ++ W E L + ++ + E +K+ + + + +D + + E +
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 140 QQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRT 199
Q+ + +E+ ++++KK+R+ EE + +K + + + ++ + + +
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ------------ 431
Query: 200 KKRISEAKEELKESKKPKKDEVKETKELKKVKKGEI---------RDLKTKTREDPKENR 250
++R+ E KE+L E +K ++ E K ++ +K++ E R K + +ED +
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 491
Query: 251 KTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGF 310
+ K + + E + + E + + +Q K E+ Q+
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE----- 546
Query: 311 EKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKL---ENKNAFLEKKTVPKKQRNQD 367
+K D E+ +R R KK + + K+ E K E+K ++++ Q+
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 368 RSKSAAELEKLMPVSAQTPKGR-----------RLSGEERGLWSTDSAEEDKETKRNESK 416
+ + E E+ M + K + ++ +E +W + ++E K E +
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Query: 417 EKYQKRHD---------SDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRK 467
EK Q + + +EEK R++ + ++ +E + EEK E R+
Sbjct: 667 EKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMRE 726
Query: 468 REEIPLDFKTIDDHKTKENKQSLKE 492
+EE D K + E+++ E
Sbjct: 727 KEERIRDQKEKMQERLPEHEERCSE 751
Score = 53.1 bits (126), Expect = 1e-06
Identities = 60/313 (19%), Positives = 139/313 (44%), Gaps = 38/313 (12%)
Query: 200 KKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVE 259
KK+ +E +E+L+ ++ K + KELK RK ++ KF+
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELK---------------------RKLERAKFLL 224
Query: 260 SQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMS 319
QV +++ L + + +++ E + + KQ K R+ + + + G + + M
Sbjct: 225 PQV--QTNTLQEEMWRQEE-ELREQEKKIRKQEEKMWRQE--ERLREQEGKMREQEEKMR 279
Query: 320 AEEDTDVRGRRKKKTPRKAE-DTRENRKLENKNAFL----EKKTVPKKQRNQDRSKSAAE 374
+E R R ++K R+ E + RE +KL + + EK +++ + K +
Sbjct: 280 RQEK---RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 336
Query: 375 LEKLMPVSAQ-TPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRK 433
E+L Q + +++ +E +W D +KE + E ++ +++ +EE+ R+
Sbjct: 337 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE 396
Query: 434 EPKGLKTLKE-IRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTI-DDHKTKENKQSL- 490
K ++ +E +R + + E + E +++ +P + + + K +E ++ +
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 456
Query: 491 KERRNTRDETDTW 503
++ RD+ + W
Sbjct: 457 EQEEKIRDQEEMW 469
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/171 (26%), Positives = 83/171 (48%), Gaps = 3/171 (1%)
Query: 552 LDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAG 611
LD D NF + L A + G V L + N++ D T +M A
Sbjct: 637 LDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGA--NINAVDKQQRTPLMEAVVN 694
Query: 612 GQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF-VNVQQSNGETA 670
++ R ++ +G V ++++G+T L HAA+ L V++LL G VN Q S G T
Sbjct: 695 NHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP 754
Query: 671 LMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKN 721
++ A + + +++R+++ GAD + +N LH+A + + + ++L N
Sbjct: 755 IIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
Score = 50.1 bits (118), Expect = 9e-06
Identities = 48/211 (22%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 567 SNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAK 626
S L A K G+ V + L++ + +++ +DS G T ++ AA +++R+L+T+GA
Sbjct: 718 STCLHHAAKIGNLEMVSLLLSTGQ-VDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGAD 776
Query: 627 VNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLV 686
V L A+ +LL A ++ +G+T L A + D V L
Sbjct: 777 VTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLF 836
Query: 687 IECGADCNILSKH---------QNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDY 737
+ GA+ + +K + S + FA Q N L + + T + + + Y
Sbjct: 837 LSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGY 896
Query: 738 FEARLALLEPVFPIACHRLCEGPDFSTDFNY 768
PI C +G D+ Y
Sbjct: 897 ENV---------PIPCVNGVDGEPCPEDYKY 918
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/107 (26%), Positives = 49/107 (45%)
Query: 613 QDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALM 672
Q +L LL Q++ T L AA+K + +LL+AGA +N T LM
Sbjct: 630 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 689
Query: 673 KACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
+A + ++ R +++ G + ++ LH A + N+ + LL
Sbjct: 690 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/171 (26%), Positives = 83/171 (48%), Gaps = 3/171 (1%)
Query: 552 LDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAG 611
LD D NF + L A + G V L + N++ D T +M A
Sbjct: 671 LDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGA--NINAVDKQQRTPLMEAVVN 728
Query: 612 GQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAF-VNVQQSNGETA 670
++ R ++ +G V ++++G+T L HAA+ L V++LL G VN Q S G T
Sbjct: 729 NHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP 788
Query: 671 LMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKN 721
++ A + + +++R+++ GAD + +N LH+A + + + ++L N
Sbjct: 789 IIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
Score = 50.1 bits (118), Expect = 9e-06
Identities = 48/211 (22%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 567 SNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAK 626
S L A K G+ V + L++ + +++ +DS G T ++ AA +++R+L+T+GA
Sbjct: 752 STCLHHAAKIGNLEMVSLLLSTGQ-VDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGAD 810
Query: 627 VNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLV 686
V L A+ +LL A ++ +G+T L A + D V L
Sbjct: 811 VTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLF 870
Query: 687 IECGADCNILSKH---------QNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDY 737
+ GA+ + +K + S + FA Q N L + + T + + + Y
Sbjct: 871 LSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGY 930
Query: 738 FEARLALLEPVFPIACHRLCEGPDFSTDFNY 768
PI C +G D+ Y
Sbjct: 931 ENV---------PIPCVNGVDGEPCPEDYKY 952
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/107 (26%), Positives = 49/107 (45%)
Query: 613 QDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALM 672
Q +L LL Q++ T L AA+K + +LL+AGA +N T LM
Sbjct: 664 QKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLM 723
Query: 673 KACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
+A + ++ R +++ G + ++ LH A + N+ + LL
Sbjct: 724 EAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/170 (28%), Positives = 81/170 (47%), Gaps = 2/170 (1%)
Query: 544 KLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMT 603
KLE+ ++ + TD L A G V+ L N +D +G +
Sbjct: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVN--DKDDAGWS 75
Query: 604 LVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQ 663
+ +AA+ G+D++++ L+ KGA+VN +NG T L +AA KN +LLE GA + +
Sbjct: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
Query: 664 QSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
TA+ +A +GN ++ +++ A NI N+ LH A V
Sbjct: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/122 (27%), Positives = 55/122 (45%)
Query: 598 DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAG 657
D T + A + G +++ L+ G VN + G + L AA V LL G
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 658 AFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYD 717
A VN NG T L A + +I +++E GA+ + ++ +A+H A N+ +
Sbjct: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
Query: 718 LL 719
+L
Sbjct: 157 IL 158
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 72.4 bits (176), Expect = 2e-12
Identities = 66/373 (17%), Positives = 162/373 (43%), Gaps = 16/373 (4%)
Query: 133 EANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLES 192
+A+ D+D + ++++++ RQ E ++ ++++ K K + + E
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDRE- 102
Query: 193 LVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKT 252
+ ++R ++ + + + K+ + + +E + ++ ++G RD +T + + + R
Sbjct: 103 -----KERERQTDRERDRQREKERNRQKERERETEREGERG--RDRQTDGQRERERQRDA 155
Query: 253 KKEKFVESQVESESSV-LNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFE 311
+KE+ ++ E + N E + RE ++ ++ E + G E E
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 312 KPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKS 371
+ ++ + TD R++KT R+ E E + + +K+ ++ R++DR +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 372 AAELEKLMPVSAQTPKGR-RLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEK 430
E E+ Q R R + +R E ++ KR +E+ ++R + E+
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335
Query: 431 GRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKE----- 485
R++ + K ++ + + T E +E R+RE D ++ + + +E
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERER-ERDRQSAREREERERDRDR 394
Query: 486 NKQSLKERRNTRD 498
++Q +ER+ +D
Sbjct: 395 DRQKERERQTEKD 407
Score = 69.7 bits (169), Expect = 1e-11
Identities = 69/341 (20%), Positives = 149/341 (43%), Gaps = 33/341 (9%)
Query: 133 EANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLES 192
E N +++ ET+ + + ++ QRE + D +K++ + + + + +
Sbjct: 120 ERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE------- 172
Query: 193 LVFDLRTKKRISEAKEELKESKKPKKDEVKETK-ELKKVKKGEIRDLKTKTREDPKENRK 251
R +++ E ++ +E ++ ++ KE K E + ++G R+ + +T + + R+
Sbjct: 173 -----RNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQ 227
Query: 252 TKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGF- 310
T +E+ + + E E E +E + RE +++ + RER +D +
Sbjct: 228 TDRERDRQRKTERER---------EKQAERERASERETERDKERERER-DRDRDRDRRQK 277
Query: 311 --EKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRE-NRKLENKNAFLEKKTVPKKQRNQD 367
E+ D + D RK++ R+ E RE NRK E + E++ ++QR +
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERER---ERERERERQRETE 334
Query: 368 RSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDK 427
R + K + + R +G E + E ++E R ++E+ ++ D D+
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 428 EEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKR 468
+ + +E + T K+ + K EK+ SE R+R
Sbjct: 395 DRQKERERQ---TEKDRDGQRETEKQREREKDRESERGRER 432
Score = 63.2 bits (152), Expect = 1e-09
Identities = 71/373 (19%), Positives = 155/373 (41%), Gaps = 35/373 (9%)
Query: 140 QQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRT 199
++ +T+ +T K+++++ + R K D +++ + + + + + D E + R
Sbjct: 67 EKRQTERETDRKRERRREKDRHRKR--DRHRERQRDREKERERQTDRERDRQREKERNRQ 124
Query: 200 KKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVE 259
K+R E + E + + + D +E + + +K R + + + NR+ ++E+
Sbjct: 125 KERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKN 184
Query: 260 SQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMS 319
Q E + +D RE ++ T++ ER Q ++ D
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQT-------DRERDRQRK 237
Query: 320 AEEDTDVRGRRKKKTPRKAEDTRE-------NRKLENKNAFLEKKTVPKKQRNQDRSKSA 372
E + + + R++ + R+ E +E +R + + E++T K+QR +R +
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297
Query: 373 A-ELEKLMPVSAQTPKGRRLSGE---ERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKE 428
+ E+ + + R+ E ER E D+E K E K K Q D ++
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDRE-KERERKRKRQTEMDRERN 356
Query: 429 EKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQ 488
+ +E G + + R E+ ++ R+REE D D + KE ++
Sbjct: 357 RQTGRE--GRRQAERERE---------RERERDRQSAREREERERD---RDRDRQKERER 402
Query: 489 SLKERRNTRDETD 501
++ R+ + ET+
Sbjct: 403 QTEKDRDGQRETE 415
Score = 61.2 bits (147), Expect = 4e-09
Identities = 57/314 (18%), Positives = 141/314 (44%), Gaps = 37/314 (11%)
Query: 133 EANSDSDQQSETKEDTSPKKKKKKLRQRE-EKSPDDLKKKKAKAGKLKDKSKPDLESSLE 191
+ ++ ++Q E + + + ++++++ RQRE E +D ++ + + + +++ + E +
Sbjct: 168 QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQ 227
Query: 192 SLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTRE---DPKE 248
+ R +K E +++ + + +++ ++ + ++ + RD + K RE D K
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKR 287
Query: 249 NRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEH 308
R+T++++ E + E + RE ++N K RER
Sbjct: 288 QRRTERDRETERKRERQ-----------------RERERERERNRKRERERER------- 323
Query: 309 GFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDR 368
E+ + E D + RK+K R+ E RE + + + + +++R +DR
Sbjct: 324 --ERERERQRETERDREKERERKRK--RQTEMDRERNRQTGREGRRQAERERERERERDR 379
Query: 369 --SKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSD 426
++ E E+ Q + R+ + G T E+ +E +++ E+ ++R
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRET---EKQREREKDRESERGRERGRER 436
Query: 427 KEEKGRKEPKGLKT 440
+++KGR+ + +T
Sbjct: 437 EKQKGRERDRERQT 450
Score = 58.5 bits (140), Expect = 3e-08
Identities = 53/292 (18%), Positives = 131/292 (44%), Gaps = 14/292 (4%)
Query: 107 RKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQRE----- 161
R++ ENK + + R E ++ +Q++ + D K ++++ +Q E
Sbjct: 193 RQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252
Query: 162 EKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEV 221
E+ + K+++ + + +D+ + E ++ R ++R +E E + ++ +++
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTD----RKRQRRTERDRETERKRERQRERE 308
Query: 222 KETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEG 281
+E + +K ++ R+ + + + + + +R+ ++E+ + Q E + N E +
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE-RNRQTGREGRRQA 367
Query: 282 LHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDT 341
RE +++ +SARER ++ + +K + E+D D G+R+ + R+ E
Sbjct: 368 ERERERERERDRQSAREREERERDRDRDRQK--ERERQTEKDRD--GQRETEKQREREKD 423
Query: 342 RENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSG 393
RE+ + + EK+ ++ R + + A K + P SG
Sbjct: 424 RESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSG 475
Score = 32.3 bits (72), Expect = 1.9
Identities = 28/126 (22%), Positives = 53/126 (42%), Gaps = 17/126 (13%)
Query: 374 ELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRK 433
+ + P S ++P+ R L G+ D E +++ +R +EK Q ++D++ + R+
Sbjct: 25 DFSRRRPGSQESPRRRGL-GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRR 83
Query: 434 EPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKE-NKQSLKE 492
E K+ D + ++ E RE D + KE N+Q +E
Sbjct: 84 E-------KDRHRKRDRHRERQRDREKERERQTDRER--------DRQREKERNRQKERE 128
Query: 493 RRNTRD 498
R R+
Sbjct: 129 RETERE 134
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 72.4 bits (176), Expect = 2e-12
Identities = 52/167 (31%), Positives = 84/167 (50%), Gaps = 8/167 (4%)
Query: 553 DGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGG 612
+G D N + + N L A K G V L E N+D G T + +A+ G
Sbjct: 63 NGVDINICNQNGL--NALHLASKEGHVEVVSELLQ--REANVDAATKKGNTALHIASLAG 118
Query: 613 QDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALM 672
Q +++++L+T GA VN + +NG T L AA++N L V LL+ GA ++ +G T L
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLA 178
Query: 673 KACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
A ++G+ +V L++E + K + ALH A + ++ LL
Sbjct: 179 VALQQGHDQVVSLLLE----NDTKGKVRLPALHIAARKDDTKAAALL 221
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/167 (30%), Positives = 83/167 (49%), Gaps = 4/167 (2%)
Query: 554 GKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQ 613
G D N I S L A + G V + L N NL + SG+T + LAA +
Sbjct: 654 GADANAVTRQGIASVHL--AAQEGHVDMVSLLLGRNANVNLSNK--SGLTPLHLAAQEDR 709
Query: 614 DDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMK 673
++ +L+ +GA V+ + K G T L + V LL+ A VN + NG T L +
Sbjct: 710 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQ 769
Query: 674 ACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLK 720
A ++G++ I+ ++++ A N L+ + N+AL A++ + V D LK
Sbjct: 770 AAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
Score = 63.9 bits (154), Expect = 6e-10
Identities = 42/127 (33%), Positives = 65/127 (51%)
Query: 595 DQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILL 654
D SG+T + +AA + LL+ +GA + KNG T L AA+KN + LL
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Query: 655 EAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVL 714
E GA N G ++ A + G+ D+V L++ A+ N+ +K + LH A Q + V
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711
Query: 715 VYDLLKN 721
V ++L N
Sbjct: 712 VAEVLVN 718
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/144 (30%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Query: 581 TVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIH 640
T AL + N D E SG T + +AA G ++ LL+ + A V+ +N T L
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 274
Query: 641 AAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQ 700
A+++ V +LL+ GA ++ + +G T L + G+ +V ++++ A ILSK +
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP--ILSKTK 332
Query: 701 N--SALHFAKQSNNVLVYDLLKNH 722
N S LH A Q +++ LL H
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQH 356
Score = 60.5 bits (145), Expect = 7e-09
Identities = 38/119 (31%), Positives = 61/119 (51%)
Query: 601 GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV 660
G T + +AA G+ ++ LL+ K A + K+G T L AA + +LL+ GA
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 661 NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
+ NG T L A K+ DI ++E GAD N +++ +++H A Q +V + LL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 59.3 bits (142), Expect = 1e-08
Identities = 44/172 (25%), Positives = 85/172 (49%), Gaps = 5/172 (2%)
Query: 560 AATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRL 619
A D P +V A K G+ VK+ L+ + +D + G+T + A G + ++ +
Sbjct: 265 ARNDITPLHV---ASKRGNANMVKLLLDRGAK--IDAKTRDGLTPLHCGARSGHEQVVEM 319
Query: 620 LITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGN 679
L+ + A + + KNG + L A + + L V +LL+ V+ ++ TAL A G+
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
Query: 680 SDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAE 731
+ +++++ A+ N + + + LH A + N + V +LL H ++ V E
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/119 (30%), Positives = 62/119 (52%)
Query: 601 GMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFV 660
G T + +AA GQ +++R L+ GA+V + K+ T L +A V LL+ GA
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Query: 661 NVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLL 719
N ++G T L + + G+ D+ +++ GA +I +K + LH A + + V +LL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 58.5 bits (140), Expect = 3e-08
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 5/194 (2%)
Query: 570 LRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG 629
L A G Y KV L+ ++ N + + +G T + +A + ++ LL+ GA +
Sbjct: 371 LHVAAHCGHYKVAKVLLD--KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 630 RQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIEC 689
++G T + AA + V+ L+ GA N GETAL A + G +++VR +++
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 690 GADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVF 749
GA +K + LH + + D+++ L+ + T Y L+ E
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKA---DIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 750 PIACHRLCEGPDFS 763
+A L G S
Sbjct: 546 DVAAFLLDHGASLS 559
Score = 50.4 bits (119), Expect = 7e-06
Identities = 35/125 (28%), Positives = 63/125 (50%)
Query: 608 AAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNG 667
AA G + I G +N +NG AL A+++ + V+ LL+ A V+ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 668 ETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLS 727
TAL A G +++V++++ GA+ N S++ + L+ A Q N++ V L ++ + S
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 728 RVAEE 732
E+
Sbjct: 168 LATED 172
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/115 (28%), Positives = 56/115 (48%)
Query: 599 SSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGA 658
+SG T + L+A G +D+ L+ GA ++ K G T L AA+ L +LL+ A
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 659 FVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNV 713
+ +G T L A N + L+++ GA + +K+ + LH A + N +
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Score = 48.1 bits (113), Expect = 3e-05
Identities = 73/325 (22%), Positives = 130/325 (40%), Gaps = 29/325 (8%)
Query: 403 SAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKG---LKTLKEIRNAFDLFKLTPEEKN 459
+AEE+ E KR K ++ SD + + K L I+N D+ N
Sbjct: 17 NAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDI--------N 68
Query: 460 DVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDET---DTWAYIAA-EGDQEVL 515
++N L + + H + + L+ N T +T +IA+ G EV+
Sbjct: 69 ICNQNGLNA----LHLASKEGH-VEVVSELLQREANVDAATKKGNTALHIASLAGQAEVV 123
Query: 516 DSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLD-GKDENFAATDAIPSNVLRDAV 574
+ N + + Q + + + LE + LD G ++ A D L A+
Sbjct: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP--LAVAL 181
Query: 575 KNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNG 634
+ G V + L + D + + + +AA LL+ + K+G
Sbjct: 182 QQGHDQVVSLLLEN------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSG 235
Query: 635 TTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCN 694
T L AA + +LL A V+ N T L A KRGN+++V+L+++ GA +
Sbjct: 236 FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295
Query: 695 ILSKHQNSALHFAKQSNNVLVYDLL 719
++ + LH +S + V ++L
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEML 320
Score = 44.7 bits (104), Expect = 4e-04
Identities = 34/142 (23%), Positives = 70/142 (49%), Gaps = 1/142 (0%)
Query: 579 YITVKVA-LNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTA 637
Y + VA L N +D + +T + +A+ G ++++LL+ +GAK++ + ++G T
Sbjct: 245 YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Query: 638 LIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILS 697
L A V +LL+ A + + NG + L A + + + V+L+++ + ++
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
Query: 698 KHQNSALHFAKQSNNVLVYDLL 719
+ALH A + V +L
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVL 386
Score = 32.0 bits (71), Expect = 2.5
Identities = 95/445 (21%), Positives = 162/445 (36%), Gaps = 86/445 (19%)
Query: 105 EFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKE----DTSPKKKKKKLRQR 160
+ K AE A+ KD Q I E + + Q+E E +T +K+ +
Sbjct: 2303 DVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRETKKHPEKEMYVYQ 2362
Query: 161 EEKSPDDLKKKKAKAGK-----------LKDKSKPDLESSLESLVFDLRTKKRISEAKEE 209
++ S D+ K K +++ + E SL S + R +S+ ++
Sbjct: 2363 KDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDS 2422
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTK---KEKFVESQVESES 266
S + D+ +T +L E D + K EK S ++E
Sbjct: 2423 RPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSDTEE 2482
Query: 267 SVLNDSPFPEDDSEGLHSDSREE----------KQNTKSARERAGQDMGLEHGFEK---- 312
SV + + P + +G SRE+ + K E + + F+K
Sbjct: 2483 SVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVL 2542
Query: 313 --------PLDSA-MSAEEDTDVRGRRK-------KKTPRKAED---------TRENRKL 347
P + M ED RGR K +T ++AE+ + KL
Sbjct: 2543 HYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFRDKTEKL 2602
Query: 348 ENKNAFLEKKTVPKKQR---NQDRSKSAAE---LEKLMPVSAQTPKGRRLSGEERGLWST 401
++ EKK PK + +Q + S+ E L +L+ + + K R+ + +G
Sbjct: 2603 NDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELLASNDEWVKARQHGPDGQGF--- 2659
Query: 402 DSAEEDKETKRNESKEKY---QKRHDSDK--EEKG----RKEPKGLKT--------LKEI 444
E+K S EK Q+ DS E KG K P G ++ L I
Sbjct: 2660 -PKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKAPDGPQSGFQLKQSKLSSI 2718
Query: 445 RNAFDLFKLTPEEKNDVSENNRKRE 469
R F+ + T + D+S+ +RK +
Sbjct: 2719 RLKFE--QGTHAKSKDMSQEDRKSD 2741
Score = 30.0 bits (66), Expect = 9.6
Identities = 20/96 (20%), Positives = 40/96 (41%)
Query: 172 KAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVK 231
K + +LK+ K +E L+ R+SE +++++ +++ L +
Sbjct: 3983 KVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETS 4042
Query: 232 KGEIRDLKTKTREDPKENRKTKKEKFVESQVESESS 267
+G + TK+ D K K K ++ E SS
Sbjct: 4043 RGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSS 4078
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.0 bits (175), Expect = 2e-12
Identities = 76/375 (20%), Positives = 176/375 (46%), Gaps = 21/375 (5%)
Query: 140 QQSETKEDTSPKKKKKKLRQR-EEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLR 198
++ E ++ ++++++L QR + + + L++++ + +LK + +P+ E + L + +
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK-REEPEEERRQQLLKSEEQ 639
Query: 199 TKKRISEAKEELKESKKP--KKDEVKETKE--LKKVKKGEIRD--LKTKTREDPKENRKT 252
++R + + E +E ++ K++E +E E LK+ + E R+ L + +E +E K+
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 253 KKEKFVESQVESESSVLNDSPFPED-DSEGLHSDSREEKQNTKSARERAGQDMGLEHGFE 311
+ K+ + Q+ESE+ + EG +E++ + E Q+ H +
Sbjct: 700 RIPKW-QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 312 KPLDSAMS------AEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRN 365
+ + AEE ++ RGR++ + RE + + E++ +P+++
Sbjct: 759 QEEEQRRDFTWQWQAEEKSE-RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 366 QDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQK-RHD 424
+ R + E EK + + + +R ++ D +ED+E +R++ + + QK R
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877
Query: 425 SDKEEKGRKEPKGLKTL--KEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHK 482
++E K R+ K +++R L + EE R+R+E ++ ++
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQL 936
Query: 483 TKENKQSLKERRNTR 497
+E +Q L+E R R
Sbjct: 937 QQEEEQLLREEREKR 951
Score = 67.8 bits (164), Expect = 4e-11
Identities = 83/425 (19%), Positives = 197/425 (46%), Gaps = 65/425 (15%)
Query: 91 EPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSP 150
E ++ E+ +E+ E R+K + + ++ ++L + + + ++ +E
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE--QLLREEREKRRRQERERQ 959
Query: 151 KKKKKKLRQREEKS-PDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISE---- 205
+K KKL+Q+EE+ ++ +K++ + + K + + +L+ E L+ + R K+R E
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 206 --AKEELKESKKPKKDEVKETKELKKVKKG--EIRDLKTKTREDPKENRKTKKEKFVESQ 261
K+EL++ ++ E +E + L++ ++ E +L+ + + E R+T++ + +E Q
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Query: 262 VESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAE 321
E + + + E L + E+++ + RER ++ + + E
Sbjct: 1080 YRKEEEL-------QQEEEQLLREEPEKRR--RQERERQCRE-----------EEELQQE 1119
Query: 322 EDTDVRGRRKKKTPRKAE-DTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMP 380
E+ +R R+K+ ++ E RE +++ + L ++ P+K+R Q+ + E E+L
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE-PEKRRRQELERQYREEEELQ- 1177
Query: 381 VSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKT 440
+E+++ R E +++ Q+R +EE+ + K +
Sbjct: 1178 ------------------------QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 441 LKEIRNAFDL-FKLTPEEKNDVSEN-----NRKREEI-PLDFKTIDDHKTKENKQSLKER 493
++ DL ++ PE++N V +N R+ E+ L+ + D +++++ Q L
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 494 RNTRD 498
+ RD
Sbjct: 1274 QQERD 1278
Score = 67.0 bits (162), Expect = 7e-11
Identities = 82/441 (18%), Positives = 194/441 (43%), Gaps = 43/441 (9%)
Query: 113 NKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKK 172
++ K R D + L + E + + + + + P +++++ RQ +E+ + +++
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 173 AKAGKL--KDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKV 230
K +L +D+ + D E + + R ++R E E+L+ K + +E + ++L
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE--EQLQSCKGHETEEFPDEEQL--- 210
Query: 231 KKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEK 290
++ E+ +L+ K RE+ ++ R+ ++++ + + E E E++ EE
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL-----QEEEP 265
Query: 291 QNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENK 350
Q + +E Q LE + L EE R RR+++ RK E+ R ++ E +
Sbjct: 266 QRQRELQEEEEQLRKLE---RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 351 NAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKET 410
++ +++ Q R + E+ + RR EER +E++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQL---------RREQEEERREQQLRREQEEERR 373
Query: 411 KRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREE 470
++ +E+ +R + E+ + + L+ +++R L + ++ + R++EE
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQEE 431
Query: 471 IPLDFKTIDDHKTKENKQSLKERRN-TRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQ 529
+ K + + + K+ +ERR+ + E +T + +QE + D+ + R+
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERH-----EQERRKQQLKRDQEEERRE 486
Query: 530 QILSLGMDLQLEWMKLEDFQK 550
+ W+KLE+ ++
Sbjct: 487 R-----------WLKLEEEER 496
Score = 67.0 bits (162), Expect = 7e-11
Identities = 81/421 (19%), Positives = 184/421 (43%), Gaps = 47/421 (11%)
Query: 81 KGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQ 140
KG+ +++ E ++ + LLE R+K E K + QR + +F+ + ++
Sbjct: 197 KGHETEEFPDEEQLRRRE----LLELRRKGREEKQQ------QRRERQDRVFQ---EEEE 243
Query: 141 QSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTK 200
+ K +T +K+++KL++ E + +L++++ + KL+ R +
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE------------------RQE 285
Query: 201 KRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENR----KTKKEK 256
R +EE ++ + ++ +++ +E ++ ++ E R + + RE +E R + ++E+
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 257 FVESQV--ESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPL 314
E Q+ E E E + E R E+Q + + R Q + E +
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 315 DSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAE 374
+ + + RR+++ R+ E+ R +K E + E++ +++ +D K E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREEE 463
Query: 375 LEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKE 434
E+ + R E R W EE++ ++ E +E+ +R ++ E+ K
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWL--KLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 435 PKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERR 494
+ + L++ + + EE+ E KREE + + + + + K+ +ERR
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERR---EQLLKREE---EKRLEQERREQRLKREQEERR 575
Query: 495 N 495
+
Sbjct: 576 D 576
Score = 66.2 bits (160), Expect = 1e-10
Identities = 75/410 (18%), Positives = 173/410 (42%), Gaps = 51/410 (12%)
Query: 141 QSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTK 200
Q E + + K ++++ R+++E+ L++++ + + + K + + E + L + + +
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 201 KRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENR---------- 250
+ E +E+L + ++ K+ E + ++ K ++ E RD K E+ ++ R
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 251 ---KTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLE 307
K ++ + +E + E + + P E + L S+ +EE++ + RE Q E
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE---QQERRE 656
Query: 308 HGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQD 367
++ EE + R +R+ + R+ ++ E + + + K +PK Q +
Sbjct: 657 QRLKRE-----EEEERLEQRLKREHEEERREQELAEEEQEQARERI--KSRIPKWQWQLE 709
Query: 368 RSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHD--- 424
A + + Q + RR EE+ + +E + + +++ ++R D
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 425 ----SDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDD 480
+K E+GR+ L+E R E+ +E ++RE+ + + +
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQR-----------ERQLRAEERQQREQ-----RFLPE 813
Query: 481 HKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQ 530
+ KE + RR R+ ++ E + + Q E DG Q+
Sbjct: 814 EEEKEQR-----RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Score = 65.1 bits (157), Expect = 3e-10
Identities = 91/442 (20%), Positives = 202/442 (45%), Gaps = 61/442 (13%)
Query: 90 WEPEIHLEDCKEVLL--EFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKED 147
+ E L+ +E LL E K+ + + + RKD + + + ++ +E
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL---GEEPEKRRRQER 986
Query: 148 TSPKKKKKKLRQREEKS-PDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEA 206
+++++L+Q EE+ ++ +K++ + + + + K +L+ E L+ + R K+R+ E
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 207 K------EELKESKKPKKDEVKETKELKKV-----KKGEIRDLKTKT-REDPKENRKTKK 254
+ EEL++ ++ E +ET+ +++ K+ E++ + + RE+P++ R+ ++
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 255 EKFV--ESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARE--------RAGQDM 304
E+ E +++ E L + + L REE++ + + R Q++
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Query: 305 GLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQR 364
++ E+ L EE+ +R ++K+ + RE +L+ + +++ + QR
Sbjct: 1167 ERQYREEEELQQ----EEEQLLREEQEKRRQERERQYREEEELQRQKR--KQRYRDEDQR 1220
Query: 365 NQDRSKSAAELEKLMPVSAQTPKGRRLSG----EERGLWSTDSAE-------EDKETKRN 413
+ + + E E + + KGR E+ L S + E +E R
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280
Query: 414 ESKEKYQK--RHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEI 471
+ + ++Q+ RH ++E+ R+E K K + R + + +L EE+ E R+R+E
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAK--RRDRKSQEEKQLLREER----EEKRRRQE- 1333
Query: 472 PLDFKTIDDHKTKENKQSLKER 493
D K +E +Q L+ER
Sbjct: 1334 -------TDRKFREEEQLLQER 1348
Score = 62.8 bits (151), Expect = 1e-09
Identities = 79/415 (19%), Positives = 187/415 (45%), Gaps = 38/415 (9%)
Query: 91 EPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSP 150
E E + +EV E + + E K R++++R + QQ E +
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL-------QQEEEQLLREE 1187
Query: 151 KKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDL----ESSLESLVFDLRT--KKRIS 204
++K+++ R+R+ + ++L+++K K + + DL E E+ V D + K R +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 205 EAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVES 264
E +L++S+ + ++ + L + + + RD + + R + +R +E+ +E + +
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 265 ESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDT 324
E+ + +++ + L + E+++ ++ R+ ++ L+ E+PL +
Sbjct: 1306 EAKRRDRK--SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 325 DVRGRRKKKTPRKAEDTRENRKLENKNAFLEKK-----TVPKKQRNQDRSKSAAELEKLM 379
+ R +++ + E+ + R+ E + FL+++ ++Q QDR + E E
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE--- 1420
Query: 380 PVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLK 439
++LS +ER EE+++ +R E + K+ + ++E+ RK + +
Sbjct: 1421 ---------QQLSRQER---DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 440 TLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERR 494
L+E R L + + K E +R+E F+ + + ++ L+E +
Sbjct: 1469 LLQE-REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Score = 61.2 bits (147), Expect = 4e-09
Identities = 73/430 (16%), Positives = 180/430 (41%), Gaps = 40/430 (9%)
Query: 97 EDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKK- 155
E+ ++ LL+ ++ + + K +++ L + E +++ + + P+++++
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 156 ---KLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKE 212
K ++EE+ L++++ + + + K + + E + L + ++R E EE +E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 213 SKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDS 272
+ + + + + + R K +R +E ++ ++E + E +S
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE-------QEEKRRRRES 744
Query: 273 PFPEDDSEGLHSDSREEKQN--------TKSARERAGQDMGLEHGFEKPLDSAMSAEEDT 324
+ E H +EE+Q + ER Q + + + + AEE
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 325 DVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQ 384
R + K + R+ R+ E + FLE++ ++ + ++R++ E E + +
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEE---EQLQRRERAQQLQEEEDGLQEDQE 861
Query: 385 TPKGRRLSGEERGLWSTDSAEEDKETKRN---------ESKEKYQKRHDSDKEEKGRKEP 435
+ + +++ W EE+++ +R+ E K Q+ ++EE R+E
Sbjct: 862 RRRSQEQRRDQKWRWQL---EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 436 KGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSL----- 490
+ + ++ R + +L EE+ + E KR + + D K ++ ++ L
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 491 -KERRNTRDE 499
K RR R++
Sbjct: 979 EKRRRQEREK 988
Score = 60.8 bits (146), Expect = 5e-09
Identities = 71/440 (16%), Positives = 206/440 (46%), Gaps = 37/440 (8%)
Query: 91 EPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQS-ETKEDTS 149
E ++ ++ + LE +++ + + + R++ Q L + + D++ E ++
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 150 PKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEE 209
+++ +K R++E +S + +K + +L + + E LR ++R + +++
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ---QLRRQERGQQRRQD 1552
Query: 210 LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVE------ 263
++ K +++++++ +E +++ + E RD K + E+ K R+ ++ KF+E + +
Sbjct: 1553 -RDRKFREEEQLRQEREEQQLSRQE-RDRKFRL-EEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 264 -SESSVLNDSPFPEDDS-------EGLHSDSREEKQNTKSAR-ERAGQDMGLEHGFEKPL 314
+ D F ED+ + LH R+ K + + R ++ L H ++
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 315 -DSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLE------KKTVPKKQRNQD 367
+ +E + + RR+++ + E+ ++ R+ E + FL+ ++ + +K R ++
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 368 RSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDK 427
+ + E E+L + + R++ EE+ + + ++ + + +E+ Q R + ++
Sbjct: 1730 QLRQETEQEQLR----RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785
Query: 428 EE-KGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDV---SENNRKREEIPLDFKTIDDHKT 483
++ + ++ + + +++R + +L P++++ E + EE + D +
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQY 1845
Query: 484 KENKQSLKERRNTRDETDTW 503
+ +Q + ++ R+E + W
Sbjct: 1846 RAEEQFATQEKSRREEQELW 1865
Score = 56.6 bits (135), Expect = 1e-07
Identities = 76/425 (17%), Positives = 187/425 (44%), Gaps = 41/425 (9%)
Query: 90 WEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTS 149
WEPE KE + K + + + ++ L + ++ D +++
Sbjct: 1227 WEPE------KENAVRDNKVYCKGRENEQFRQLEDSQLRDR--QSQQDLQHLLGEQQERD 1278
Query: 150 PKKKKKKLRQREEKSPDD--LKKKKAKAGKLKDKSKPDLESSLESLVFDLR----TKKRI 203
++++++ +QR+ P++ L++++ K K +D+ + + L + R T ++
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 204 SEAKEELKES-----KKPKKDEVKETKELKKVKKG-EIRDLKTKTREDPKENRKTKKEKF 257
E ++ L+E ++ ++D +EL+ ++G + + + + R +E + K+E+
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 258 VESQV-ESESSVLNDSPFPEDDSEGLHSDS-----REEKQNTKSARERA---GQDMGLEH 308
+ Q E + D F E++ + + EE+Q + RER + +
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 309 GFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDR 368
K + +E + + R+++ + E+ ++ R+ E F E++ R+Q+
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL-----RSQEP 1513
Query: 369 SKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKE 428
+ E E+ + + + R+ EE+ L + ++ ++ + + +E+ Q R + +++
Sbjct: 1514 ERKFLEEEQQLH---RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 429 EKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQ 488
+ R+E L+E + + + E K E +R+E + D K +E++Q
Sbjct: 1571 QLSRQERDRKFRLEEQK----VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 489 SLKER 493
L+ER
Sbjct: 1627 LLQER 1631
Score = 50.8 bits (120), Expect = 5e-06
Identities = 62/403 (15%), Positives = 171/403 (42%), Gaps = 22/403 (5%)
Query: 91 EPEIHLEDCKEVLLEFRKKIA-ENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTS 149
E ++H + + L+ +++ + + + R+D R + + Q S + D
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 150 PKKKKKKLRQREE--KSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAK 207
+ +++K+R++E+ K +D ++ + + G+ + + + D + + + R ++++ +
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 208 EE---LKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVES 264
+ L+E + ++ E ++ + +K + + E+ + R+ + KF E + +
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 265 ESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDT 324
E+ R+ ++ + +E + + + + K L+ E
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 325 DVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQ 384
+ + RR+++ + E+ E + E + L + +K R +++ + E ++L P
Sbjct: 1761 EQQLRRQERDRKFREE--EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP---- 1814
Query: 385 TPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEI 444
++ G+ R EE ++ R E +Y+ +EK R+E + L +E
Sbjct: 1815 ----QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Query: 445 RNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENK 487
+ + E+ E+ R++++ + + + K++E K
Sbjct: 1871 K------RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,033,442
Number of Sequences: 37866
Number of extensions: 1562112
Number of successful extensions: 20489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 621
Number of HSP's successfully gapped in prelim test: 1220
Number of HSP's that attempted gapping in prelim test: 8173
Number of HSP's gapped (non-prelim): 7517
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.