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Search of human proteins with 40068483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40068483 SET domain containing 3 isoform b [Homo sapiens]
(296 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40068483 SET domain containing 3 isoform b [Homo sapiens] 602 e-172
gi|40068481 SET domain containing 3 isoform a [Homo sapiens] 578 e-165
gi|238550107 SET domain containing 6 isoform a [Homo sapiens] 53 3e-07
gi|238550105 SET domain containing 6 isoform b [Homo sapiens] 53 3e-07
gi|55953063 SET domain containing 4 isoform c [Homo sapiens] 48 1e-05
gi|8393013 SET domain containing 4 isoform a [Homo sapiens] 48 1e-05
gi|222418639 melanoma antigen family B, 2 [Homo sapiens] 31 1.5
gi|20162572 necdin-like 2 [Homo sapiens] 30 1.9
gi|239753487 PREDICTED: hypothetical protein [Homo sapiens] 30 2.5
gi|239748063 PREDICTED: hypothetical protein [Homo sapiens] 30 2.5
gi|239741956 PREDICTED: hypothetical protein XP_002342400 [Homo ... 30 2.5
gi|167466190 forkhead box P3 isoform b [Homo sapiens] 28 9.7
gi|31982943 forkhead box P3 isoform a [Homo sapiens] 28 9.7
gi|7661548 methylmalonic aciduria (cobalamin deficiency) cblD ty... 28 9.7
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 28 9.7
gi|148529025 pleckstrin homology domain containing, family G (wi... 28 9.7
>gi|40068483 SET domain containing 3 isoform b [Homo sapiens]
Length = 296
Score = 602 bits (1552), Expect = e-172
Identities = 296/296 (100%), Positives = 296/296 (100%)
Query: 1 MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI 60
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI
Sbjct: 1 MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI 60
Query: 61 RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF 120
RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
Sbjct: 61 RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF 120
Query: 121 LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP 180
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP
Sbjct: 121 LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP 180
Query: 181 SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT 240
SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT
Sbjct: 181 SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT 240
Query: 241 YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLTPEDSFALAVASA 296
YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLTPEDSFALAVASA
Sbjct: 241 YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLTPEDSFALAVASA 296
>gi|40068481 SET domain containing 3 isoform a [Homo sapiens]
Length = 594
Score = 578 bits (1491), Expect = e-165
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 1 MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI 60
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI
Sbjct: 1 MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKI 60
Query: 61 RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF 120
RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
Sbjct: 61 RKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF 120
Query: 121 LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP 180
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP
Sbjct: 121 LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLP 180
Query: 181 SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT 240
SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT
Sbjct: 181 SEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFT 240
Query: 241 YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGL 283
YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGL
Sbjct: 241 YEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGL 283
>gi|238550107 SET domain containing 6 isoform a [Homo sapiens]
Length = 473
Score = 53.1 bits (126), Expect = 3e-07
Identities = 51/185 (27%), Positives = 84/185 (45%), Gaps = 16/185 (8%)
Query: 105 GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIALAFHLL 162
G+G+ A ++A EL VPR L++ + +G L ++R+ LQ+ G + L LL
Sbjct: 74 GYGMVARESVQAGELLFVVPRAALLSQHTCS---IGGLLERERVALQSQSGWVPLLLALL 130
Query: 163 CERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTARQY-A 218
E +P S W+PY P + P+++ E+E R LQ T V N +Y +
Sbjct: 131 HELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQS 190
Query: 219 YFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRV----TLALIPLW 274
++ HP L ++ + E Y V+ VM Q P E+ + ++P
Sbjct: 191 IVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAA 247
Query: 275 DMCNH 279
D+ NH
Sbjct: 248 DILNH 252
>gi|238550105 SET domain containing 6 isoform b [Homo sapiens]
Length = 449
Score = 53.1 bits (126), Expect = 3e-07
Identities = 51/185 (27%), Positives = 84/185 (45%), Gaps = 16/185 (8%)
Query: 105 GFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRI-LQAM-GNIALAFHLL 162
G+G+ A ++A EL VPR L++ + +G L ++R+ LQ+ G + L LL
Sbjct: 50 GYGMVARESVQAGELLFVVPRAALLSQHTCS---IGGLLERERVALQSQSGWVPLLLALL 106
Query: 163 CERASPNSFWQPYIQTLP--SEYDTPLYFEEDEVR-YLQSTQAIHDVFSQYKNTARQY-A 218
E +P S W+PY P + P+++ E+E R LQ T V N +Y +
Sbjct: 107 HELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQS 166
Query: 219 YFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRV----TLALIPLW 274
++ HP L ++ + E Y V+ VM Q P E+ + ++P
Sbjct: 167 IVLPFMEAHPDLFSLRVR---SLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAA 223
Query: 275 DMCNH 279
D+ NH
Sbjct: 224 DILNH 228
>gi|55953063 SET domain containing 4 isoform c [Homo sapiens]
Length = 307
Score = 47.8 bits (112), Expect = 1e-05
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 13/232 (5%)
Query: 59 KIRKKQKGLSVTFDGKREDY---FPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIK 115
+IR+++ S G E + F +L KW F G GL + ++
Sbjct: 10 RIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQ 69
Query: 116 AEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCER-ASPNSFWQP 174
++ + +P L+T ++ S LG ++ + + +AL L+ E+ A S W+P
Sbjct: 70 EGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSP-LLALCTFLVSEKHAGHRSLWKP 128
Query: 175 YIQTLPSEYDTPLYFEEDEVRYL-QSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKL 233
Y++ LP Y P+ E + V L +S +A + Q + +A +
Sbjct: 129 YLEILPKAYTCPVCLEPEVVNLLPKSLKAKAE--EQRAHVQEFFASSRDFFSSLQPLFAE 186
Query: 234 PLKDSFTYEDYRWAVSSVMT-----RQNQIPTEDGSRVTLALIPLWDMCNHT 280
+ F+Y WA +V T R Q T AL P D+ NH+
Sbjct: 187 AVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHS 238
>gi|8393013 SET domain containing 4 isoform a [Homo sapiens]
Length = 440
Score = 47.8 bits (112), Expect = 1e-05
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 13/232 (5%)
Query: 59 KIRKKQKGLSVTFDGKREDY---FPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIK 115
+IR+++ S G E + F +L KW F G GL + ++
Sbjct: 10 RIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQ 69
Query: 116 AEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCER-ASPNSFWQP 174
++ + +P L+T ++ S LG ++ + + +AL L+ E+ A S W+P
Sbjct: 70 EGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSP-LLALCTFLVSEKHAGHRSLWKP 128
Query: 175 YIQTLPSEYDTPLYFEEDEVRYL-QSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKL 233
Y++ LP Y P+ E + V L +S +A + Q + +A +
Sbjct: 129 YLEILPKAYTCPVCLEPEVVNLLPKSLKAKAE--EQRAHVQEFFASSRDFFSSLQPLFAE 186
Query: 234 PLKDSFTYEDYRWAVSSVMT-----RQNQIPTEDGSRVTLALIPLWDMCNHT 280
+ F+Y WA +V T R Q T AL P D+ NH+
Sbjct: 187 AVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHS 238
>gi|222418639 melanoma antigen family B, 2 [Homo sapiens]
Length = 319
Score = 30.8 bits (68), Expect = 1.5
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 9/131 (6%)
Query: 7 VKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKK-QK 65
V + KS GA + K + + K S P K VQ KI+K K
Sbjct: 76 VSSTKSKKGAKSHQGEKNASSSQASTSTKSPSEDPLTRKSGS-LVQFLLYKYKIKKSVTK 134
Query: 66 GLSVTFDGKR-EDYFPDLMKWASENGASVEGFEM--VNFKEEGFGLRATRDIKAEELFL- 121
G + GKR ++FP+++K ASE + V G E+ VN + D+ EE L
Sbjct: 135 GEMLKIVGKRFREHFPEILKKASEGLSVVFGLELNKVNPNGHTYTFIDKVDLTDEESLLS 194
Query: 122 ---WVPRKLLM 129
+ RKLLM
Sbjct: 195 SWDFPRRKLLM 205
>gi|20162572 necdin-like 2 [Homo sapiens]
Length = 304
Score = 30.4 bits (67), Expect = 1.9
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 8/74 (10%)
Query: 37 SSPAPGPGKEWEEYVQIRTLVE--------KIRKKQKGLSVTFDGKREDYFPDLMKWASE 88
++PA GP + + +++ LV+ KI K+ + G +D FPDL K A+E
Sbjct: 73 AAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYKDIFPDLFKRAAE 132
Query: 89 NGASVEGFEMVNFK 102
V G+++V +
Sbjct: 133 RLQYVFGYKLVELE 146
>gi|239753487 PREDICTED: hypothetical protein [Homo sapiens]
Length = 163
Score = 30.0 bits (66), Expect = 2.5
Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 12 SGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWE-EYVQIRTLVEKIRKKQKGLSVT 70
S T +++ +S K+ + E + + P PG W ++ R Q+ T
Sbjct: 35 STTNSSSVISEKKPADSAEEQEMQPGTRIPVPGSSWSLPRTPTHLIIMATRPAQQARHTT 94
Query: 71 FDGK----REDYFPDLMKWASE 88
F + R Y P L KW SE
Sbjct: 95 FTAQNHPARGSYHPCLTKWESE 116
>gi|239748063 PREDICTED: hypothetical protein [Homo sapiens]
Length = 163
Score = 30.0 bits (66), Expect = 2.5
Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 12 SGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWE-EYVQIRTLVEKIRKKQKGLSVT 70
S T +++ +S K+ + E + + P PG W ++ R Q+ T
Sbjct: 35 STTNSSSVISEKKPADSAEEQEMQPGTRIPVPGSSWSLPRTPTHLIIMATRPAQQARHTT 94
Query: 71 FDGK----REDYFPDLMKWASE 88
F + R Y P L KW SE
Sbjct: 95 FTAQNHPARGSYHPCLTKWESE 116
>gi|239741956 PREDICTED: hypothetical protein XP_002342400 [Homo
sapiens]
Length = 163
Score = 30.0 bits (66), Expect = 2.5
Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 12 SGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWE-EYVQIRTLVEKIRKKQKGLSVT 70
S T +++ +S K+ + E + + P PG W ++ R Q+ T
Sbjct: 35 STTNSSSVISEKKPADSAEEQEMQPGTRIPVPGSSWSLPRTPTHLIIMATRPAQQARHTT 94
Query: 71 FDGK----REDYFPDLMKWASE 88
F + R Y P L KW SE
Sbjct: 95 FTAQNHPARGSYHPCLTKWESE 116
>gi|167466190 forkhead box P3 isoform b [Homo sapiens]
Length = 396
Score = 28.1 bits (61), Expect = 9.7
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 3/38 (7%)
Query: 6 RVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGP 43
RV+++K GA TV E S+ +CS+P PGP
Sbjct: 362 RVESEK---GAVWTVDELEFRKKRSQRPSRCSNPTPGP 396
>gi|31982943 forkhead box P3 isoform a [Homo sapiens]
Length = 431
Score = 28.1 bits (61), Expect = 9.7
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 3/38 (7%)
Query: 6 RVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGP 43
RV+++K GA TV E S+ +CS+P PGP
Sbjct: 397 RVESEK---GAVWTVDELEFRKKRSQRPSRCSNPTPGP 431
>gi|7661548 methylmalonic aciduria (cobalamin deficiency) cblD type,
with homocystinuria precursor [Homo sapiens]
Length = 296
Score = 28.1 bits (61), Expect = 9.7
Identities = 29/99 (29%), Positives = 38/99 (38%), Gaps = 9/99 (9%)
Query: 136 NSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDE-- 193
+ +GP QD+ Q GNI HL + S +TLP PL E E
Sbjct: 59 DETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSLVH---KTLPDVLAEPLSSERHEFV 115
Query: 194 -VRYLQSTQAIHDVFSQYKNTARQYAYFYKV---IQTHP 228
+Y+ Q Q N+A Y +V IQT P
Sbjct: 116 MAQYVNEFQGNDAPVEQEINSAETYFESARVECAIQTCP 154
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 28.1 bits (61), Expect = 9.7
Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 73 GKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLL 128
G + YF ++ + A + FE ++GFGL AT+D E LW LL
Sbjct: 2217 GHTDHYFSQDVRVTARLLAHLLAFES---HQQGFGLTATQDAHFNENLLWAGSALL 2269
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 28.1 bits (61), Expect = 9.7
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 1/44 (2%)
Query: 13 GTGATATVSPKEILNLTSELLQKCSSPAPGP-GKEWEEYVQIRT 55
GTG + PK++L+++ ELLQ PG + VQ+RT
Sbjct: 178 GTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRT 221
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,533,647
Number of Sequences: 37866
Number of extensions: 505730
Number of successful extensions: 1267
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1260
Number of HSP's gapped (non-prelim): 17
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.