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Search of human proteins with 38570135
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38570135 mitogen-activated protein kinase kinase kinase
kinase 5 [Homo sapiens]
(846 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 1731 0.0
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 1731 0.0
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 1174 0.0
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 853 0.0
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 739 0.0
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 719 0.0
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 265 2e-70
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 263 5e-70
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 263 5e-70
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 263 5e-70
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 263 5e-70
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 263 5e-70
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 263 5e-70
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 263 5e-70
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 263 5e-70
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 257 3e-68
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 257 3e-68
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 257 3e-68
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 257 3e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 256 5e-68
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 256 5e-68
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 256 5e-68
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 256 5e-68
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 255 1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 254 3e-67
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 250 3e-66
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 250 4e-66
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 245 1e-64
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 233 7e-61
gi|145275208 myosin IIIA [Homo sapiens] 228 1e-59
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 1731 bits (4483), Expect = 0.0
Identities = 846/846 (100%), Positives = 846/846 (100%)
Query: 1 MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
Sbjct: 1 MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
Query: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
Sbjct: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
Query: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
Sbjct: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Query: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
Sbjct: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
Query: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
Sbjct: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
Query: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
Sbjct: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
Query: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
Sbjct: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
Query: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
Sbjct: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
Query: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
Sbjct: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
Query: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
Sbjct: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
Query: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
Sbjct: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
Query: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
Sbjct: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
Query: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
Sbjct: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
Query: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
Sbjct: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
Query: 841 GHENSY 846
GHENSY
Sbjct: 841 GHENSY 846
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 1731 bits (4483), Expect = 0.0
Identities = 846/846 (100%), Positives = 846/846 (100%)
Query: 1 MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
Sbjct: 1 MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
Query: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
Sbjct: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
Query: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
Sbjct: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Query: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
Sbjct: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
Query: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
Sbjct: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
Query: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
Sbjct: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
Query: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
Sbjct: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
Query: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
Sbjct: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
Query: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
Sbjct: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
Query: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
Sbjct: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
Query: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
Sbjct: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
Query: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
Sbjct: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
Query: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
Sbjct: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
Query: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
Sbjct: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
Query: 841 GHENSY 846
GHENSY
Sbjct: 841 GHENSY 846
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 1174 bits (3036), Expect = 0.0
Identities = 592/899 (65%), Positives = 704/899 (78%), Gaps = 62/899 (6%)
Query: 5 LRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ 64
+ P D+ RRNPQ+D+EL+QR+GSGTYGDVYKARNV+TGELAA+K+IKLEPG+DF+++QQ
Sbjct: 1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60
Query: 65 EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRET 124
EI M+K+CKH NIVAYFGSYL R+KLWICME+CGGGSLQDIYHVTGPLSELQIAYV RET
Sbjct: 61 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
LQGL YLH+KGKMHRDIKGANILLTD+G VKLADFGV+A+ITATIAKRKSFIGTPYWMAP
Sbjct: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180
Query: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
EVAAVE+ GGYNQLCD+WAVGITAIEL ELQPPMFDLHPMRALFLM+KSNFQPPKLKDK
Sbjct: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240
Query: 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYT 304
KWS++FH+FVK+ALTKNPKKRPTAE+LL H FV Q L+R+LA+ELLDKVNNPD H+ Y
Sbjct: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH-LTRSLAIELLDKVNNPD-HSTYH 298
Query: 305 EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLS--- 361
+ DDDD EP + H I ST+RN R E+T SEI F +++F+PPLRKETE E+ S
Sbjct: 299 DFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGF 358
Query: 362 ------------SDPNFMLQWNP-----FVDGANTG------------------------ 380
S+ + L++ + GAN
Sbjct: 359 LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGD 418
Query: 381 -----KSTSKRAIPPPLPPKPRISSYPED-NFPDEEKASTIKHCPDSESRA-PQILRRQS 433
ST K IPPPLPPKP+ P++ + ++E TIK CP S S A P + +
Sbjct: 419 DDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP 478
Query: 434 SPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPR-----KKDKRDFPKPAINGLPP 488
P P + ++GNG +L E Q R +K+K+D PKP NGLPP
Sbjct: 479 PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP 538
Query: 489 TPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQ 548
TPKV MGACFSKVF+GCPLKI+CA+SWI+PDT+DQY+IFG E+GIYTLNLNELHE +MEQ
Sbjct: 539 TPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQ 598
Query: 549 LFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKK-PGLAAHIQTHRFPDRILP 607
LFPR+CTWLYV+NN L+S+S GK QLYSHNL LF++A++ L I H+ PDRILP
Sbjct: 599 LFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILP 657
Query: 608 RKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFP 667
RKF+++ KIP+TK C KCC+VRNPYTGHKYLCGALQ+ IVLL+W EPMQKFMLIKH DFP
Sbjct: 658 RKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFP 717
Query: 668 LPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLD 727
+P PL +FEMLV+PEQEYP+VCV +S+G + NQVV+FET+N NS SSWFTE + + Q +
Sbjct: 718 IPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTE--SDTPQTN 775
Query: 728 SIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWK 787
HVTQLERDT+LVCLD +KIVNLQG+LKSS+KL+SEL+FDF+IES+VCLQDSVLAFWK
Sbjct: 776 VTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWK 835
Query: 788 HGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY 846
HGMQG+SF+S+EVTQEISD TR+FRLLGSDRVVVLESRPT+NPTA+SNLYILAGHENSY
Sbjct: 836 HGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 853 bits (2205), Expect = 0.0
Identities = 448/850 (52%), Positives = 592/850 (69%), Gaps = 48/850 (5%)
Query: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
D+ ++P+ +EL+QRVG+GTYGDVYKAR+ T ELAAVKI+KL+PGDD S +QQEI ++
Sbjct: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
Query: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
+EC+H N+VAY GSYL ++LWICME+CGGGSLQ+IYH TGPL E QIAYVCRE L+GL
Sbjct: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
+LH++GK+HRDIKGAN+LLT GDVKLADFGV+ ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
E+ GGYN+LCD+WA+GITAIELGELQPP+F LHPMRAL LMSKS+FQPPKL+DKT+W+
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
FH+F+K+ALTKNPKKRPTAE+LL H F Q L RAL +LLDK ++P H +D
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDP--HLGTPSPEDC 302
Query: 310 DFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDE--------MGLS 361
+ E + + TI S ++ AERT SEI F +++F P RKET+ +E +G
Sbjct: 303 ELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKE 362
Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
+LQ V A +S + R+ S + E + PD + TIK
Sbjct: 363 ELSGSLLQ---SVQEALEERSLTIRS----------ASEFQELDSPD-DTMGTIK----- 403
Query: 422 ESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLP----RKKDKRD 477
RAP + + P P E S G + G +P LP K + D
Sbjct: 404 --RAPFLGPLPTDP---PAEEPLSSPPG-----TLPPPPSGPNSSPLLPTAWATMKQRED 453
Query: 478 FPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLN 537
+ + +GLPPTPKV MGACFSKVF+GCPL+I+ A +WIHP T+DQ+++ G E+GIYTLN
Sbjct: 454 PERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLN 513
Query: 538 LNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAK-KPGLAAHI 596
L+ELHE T+E+L +C+WLY +NN L+SLS GK+ +++H+L LFE + + + I
Sbjct: 514 LHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRRLQQQVPLSI 572
Query: 597 QTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQ 656
T+R RI+PR+FAL+TKIPDTKGC +C +VRNPYTG +L AL + ++LLQWYEP+Q
Sbjct: 573 PTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQ 632
Query: 657 KFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF 716
KF+L+K+F PLPSP + E LV+ +E P VCV V F + L + +
Sbjct: 633 KFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPD 692
Query: 717 TEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVV 776
I + V Q++RDT+LV ++ V+IVN+QG + + LA EL+FDF IE+VV
Sbjct: 693 ILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVV 750
Query: 777 CLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNL 836
CLQDSVLAFW HGMQG+S ++EVTQEI+DETR+FR+LG+ R ++LES PT+NP AHSNL
Sbjct: 751 CLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNL 810
Query: 837 YILAGHENSY 846
YIL GH+++Y
Sbjct: 811 YILTGHQSTY 820
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 739 bits (1909), Expect = 0.0
Identities = 397/846 (46%), Positives = 541/846 (63%), Gaps = 50/846 (5%)
Query: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
DI R+P+ Y+L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
K C+H NIVAY GSYL +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
FHNF+K+ LTK+PKKRP+A ++L+H V+QPGL+R L ++LLDK+ NP + +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
Query: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
+ E I IRST+R++ A+ + F KL + PP S
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
S P L + D + T PPPLPPKP+ S P D P D
Sbjct: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
Query: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
+P +L R +SP GP TS S ++ ++E S P
Sbjct: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
Query: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
R+ KP + LPP + + A K+F+GCPL+I+ +W HP TKDQ+++ G E+G
Sbjct: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
Query: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
I+ LN N+ EAT+E LFP + TW+Y INN LMSLS GKT LYSH+++ L E +K
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
Query: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
A + H P R+L RK ++TKI DTKGC CC+ +G +LCGAL++ +VLLQWY
Sbjct: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
Query: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
+PM KF+L++ FPLP+PL+VF +L P E P VC+ +S G V+ F T+ +
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
Query: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
S W E+ ++ + VTQ+E D V+V +D VK+V +G + E+ +
Sbjct: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
Query: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
E+V + + AFWKHG+Q + SD++ QE+ D T FRLLGS R VV+E+RP ++PTA
Sbjct: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTA 813
Query: 833 HSNLYI 838
SNLYI
Sbjct: 814 PSNLYI 819
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 719 bits (1855), Expect = 0.0
Identities = 395/853 (46%), Positives = 537/853 (62%), Gaps = 56/853 (6%)
Query: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
DI R+P+ Y+L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
K C+H NIVAY GSYL +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
FHNF+K+ LTK+PKKRP+A ++L+H V+QPGL+R L ++LLDK+ NP + +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
Query: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
+ E I IRST+R++ A+ + F KL + PP S
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
S P L + D + T PPPLPPKP+ S P D P D
Sbjct: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
Query: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
+P +L R +SP GP TS S ++ ++E S P
Sbjct: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
Query: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
R+ KP + LPP + + A K+F+GCPL+I+ +W HP TKDQ+++ G E+G
Sbjct: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
Query: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
I+ LN N+ EAT+E LFP + TW+Y INN LMSLS GKT LYSH+++ L E +K
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
Query: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
A + H P R+L RK ++TKI DTKGC CC+ +G +LCGAL++ +VLLQWY
Sbjct: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
Query: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
+PM KF+L++ FPLP+PL+VF +L P E P VC+ +S G V+ F T+ +
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
Query: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
S W E+ ++ + VTQ+E D V+V +D VK+V +G + E+ +
Sbjct: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
Query: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
E+V + + AFWKHG+Q + SD++ QE+ D T FRLLGS R LE T +P
Sbjct: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP-- 808
Query: 833 HSNLYILAGHENS 845
H NL +L G NS
Sbjct: 809 HCNL-LLPGSSNS 820
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 265 bits (676), Expect = 2e-70
Identities = 141/299 (47%), Positives = 193/299 (64%), Gaps = 9/299 (3%)
Query: 13 RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKE 71
R +P++ + + R+G G++G+VYK + HT E+ A+KII LE +D IQQEI ++ +
Sbjct: 13 RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 72
Query: 72 CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131
C I YFGSYL KLWI MEY GGGS D+ GPL E IA + RE L+GL YL
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYL 131
Query: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEK 191
H++ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV K
Sbjct: 132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---K 188
Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
Y+ DIW++GITAIEL + +PP DLHPMR LFL+ K++ PP L+ + S F
Sbjct: 189 QSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPFK 244
Query: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
FV+ L K+P+ RPTA+ LL H F+ + + EL+D+ + H E+ +D
Sbjct: 245 EFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSED 303
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 263 bits (672), Expect = 5e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
Query: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
Query: 350 KETEARDEM 358
E R ++
Sbjct: 365 SEALRRQQL 373
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 257 bits (657), Expect = 3e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
Query: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 289 ELLDKVN 295
+L D ++
Sbjct: 301 QLKDHID 307
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 257 bits (657), Expect = 3e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
Query: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 289 ELLDKVN 295
+L D ++
Sbjct: 301 QLKDHID 307
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 257 bits (657), Expect = 3e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
Query: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 289 ELLDKVN 295
+L D ++
Sbjct: 301 QLKDHID 307
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 257 bits (657), Expect = 3e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
Query: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 289 ELLDKVN 295
+L D ++
Sbjct: 301 QLKDHID 307
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 256 bits (655), Expect = 5e-68
Identities = 133/305 (43%), Positives = 192/305 (62%), Gaps = 9/305 (2%)
Query: 7 PAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQE 65
P L+ +P++ + ++++G G++G+V+K + T ++ A+KII LE +D IQQE
Sbjct: 11 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70
Query: 66 IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETL 125
I ++ +C + Y+GSYL KLWI MEY GGGS D+ GPL E QIA + RE L
Sbjct: 71 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129
Query: 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPE 185
+GL YLH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T KR +F+GTP+WMAPE
Sbjct: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
Query: 186 VAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTK 245
V K Y+ DIW++GITAIEL +PP +LHPM+ LFL+ K+N PP L+
Sbjct: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242
Query: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTE 305
+S FV+ L K P RPTA+ LL H F+ + + EL+D+ + +
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302
Query: 306 ADDDD 310
+ +D
Sbjct: 303 SSSED 307
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 256 bits (655), Expect = 5e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
Query: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
++L D ++ E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 256 bits (655), Expect = 5e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
Query: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
++L D ++ E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 256 bits (655), Expect = 5e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
Query: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
++L D ++ E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 255 bits (652), Expect = 1e-67
Identities = 132/300 (44%), Positives = 191/300 (63%), Gaps = 9/300 (3%)
Query: 12 LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVK 70
L+ +P++ + ++++G G++G+V+K + T ++ A+KII LE +D IQQEI ++
Sbjct: 28 LKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLS 87
Query: 71 ECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAY 130
+C + Y+GSYL KLWI MEY GGGS D+ GPL E QIA + RE L+GL Y
Sbjct: 88 QCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDY 146
Query: 131 LHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE 190
LH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T KR +F+GTP+WMAPEV
Sbjct: 147 LHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 203
Query: 191 KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTF 250
K Y+ DIW++GITAIEL +PP +LHPM+ LFL+ K+N PP L+ +S
Sbjct: 204 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--NYSKPL 259
Query: 251 HNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
FV+ L K P RPTA+ LL H F+ + + EL+D+ + ++ +D
Sbjct: 260 KEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSED 319
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 254 bits (648), Expect = 3e-67
Identities = 130/297 (43%), Positives = 188/297 (63%), Gaps = 9/297 (3%)
Query: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
+P++ + ++R+G G++G+V+K + T ++ A+KII LE +D IQQEI ++ +C
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
+ Y+GSYL KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH+
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
+ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV +
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQS 194
Query: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Y+ DIW++GITAIEL + +PP D+HPMR LFL+ K+N PP L ++ +F F
Sbjct: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEF 250
Query: 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
+ L K+P RPTA+ LL H F+ + + EL+D+ H + D +
Sbjct: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 307
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 250 bits (639), Expect = 3e-66
Identities = 141/353 (39%), Positives = 212/353 (60%), Gaps = 25/353 (7%)
Query: 1 MEAPLRPAA-------DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL 53
ME P P + D L + P++ +++++++G G+YG V+KA + +G++ A+K + +
Sbjct: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
Query: 54 EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-L 112
E D I +EI ++++C +V Y+GSY LWI MEYCG GS+ DI + L
Sbjct: 61 E--SDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
Query: 113 SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
E +IA + + TL+GL YLH K+HRDIK NILL G KLADFGVA ++T T+AKR
Sbjct: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
Query: 173 KSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK 232
+ IGTP+WMAPEV + GYN + DIW++GIT+IE+ E +PP D+HPMRA+F++
Sbjct: 179 NTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 235
Query: 233 SNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV--AQP-GLSRALAVE 289
+ PP + WS F +FVK L KNP++R TA +LL H F+ A+P + R L E
Sbjct: 236 N--PPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
Query: 290 LLD-KVNNPDNHAHYTE-----ADDDDFEPHAIIRHTIRSTNRNARAERTASE 336
++ K + E +D+D+ + H +++ ++ S RA T SE
Sbjct: 294 AMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVG-TMRATSTMSE 345
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 250 bits (638), Expect = 4e-66
Identities = 133/306 (43%), Positives = 197/306 (64%), Gaps = 12/306 (3%)
Query: 10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
D L + P++ +++++++G G+YG VYKA + TG++ A+K + +E D I +EI ++
Sbjct: 20 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77
Query: 70 KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-LSELQIAYVCRETLQGL 128
++C ++V Y+GSY LWI MEYCG GS+ DI + L+E +IA + + TL+GL
Sbjct: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
Query: 129 AYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAA 188
YLH K+HRDIK NILL G KLADFGVA ++T T+AKR + IGTP+WMAPEV
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196
Query: 189 VEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSS 248
+ GYN + DIW++GITAIE+ E +PP D+HPMRA+F++ + PP + WS
Sbjct: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252
Query: 249 TFHNFVKIALTKNPKKRPTAERLLTHTFV-AQPGLS--RALAVELLD-KVNNPDNHAHYT 304
F +FVK L K+P++R TA +LL H FV + G+S R L E +D K+ ++
Sbjct: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312
Query: 305 EADDDD 310
+ DD++
Sbjct: 313 DQDDEE 318
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 245 bits (625), Expect = 1e-64
Identities = 164/470 (34%), Positives = 246/470 (52%), Gaps = 26/470 (5%)
Query: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
+P + +E+V +G G +G VYKA+N TG LAA K+I+ + ++ EI ++ C H
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
Query: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
IV G+Y KLWI +E+C GG++ I + L+E QI VCR+ L+ L +LH+
Sbjct: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
K +HRD+K N+L+T GD++LADFGV+AK T+ KR SFIGTPYWMAPEV E K
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
+ Y+ DIW++GIT IE+ +++PP +L+PMR L ++KS+ PP L +KWS F
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268
Query: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDF 311
+F+KIAL KNP+ RP+A +LL H FV+ ++AL EL+ + D+ +
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALR-ELVAEAKAEVMEEIEDGRDEGEE 327
Query: 312 EPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL-------SSDP 364
E T+ + +N+ +E + +N DK E P ++ + + S D
Sbjct: 328 EDAVDAASTLENHTQNS-SEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDR 386
Query: 365 NFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESR 424
+ P V N + A+P PL +S E++ +
Sbjct: 387 SLQTTSPPVVAPGN----ENGLAVPVPLRKSRPVSMDARIQVAQEKQVA-----EQGGDL 437
Query: 425 APQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKD 474
+P R Q + P SS G KL + + E AQA P K+D
Sbjct: 438 SPAANRSQKASQSRP---NSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 233 bits (593), Expect = 7e-61
Identities = 119/266 (44%), Positives = 166/266 (62%), Gaps = 5/266 (1%)
Query: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
NP+ +E++ +G G +G VYKA+N T LAA K+I + ++ EI ++ C H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
NIV ++ LWI +E+C GG++ + + PL+E QI VC++TL L YLH
Sbjct: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
+HRD+K NIL T GD+KLADFGV+AK T TI +R SFIGTPYWMAPEV E K
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
+ Y+ D+W++GIT IE+ E++PP +L+PMR L ++KS +PP L ++WSS F
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Query: 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
+F+K L KN R T +LL H FV
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFV 292
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 228 bits (582), Expect = 1e-59
Identities = 126/280 (45%), Positives = 176/280 (62%), Gaps = 21/280 (7%)
Query: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECK 73
+P +E+ + +G GTYG V+K N G+ AAVKI L+P D I+ E ++K
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73
Query: 74 -HCNIVAYFGSYLSREK-----LWICMEYCGGGSLQDIYHVTGPL------SELQIAYVC 121
H N+V ++G Y ++K LW+ +E C GGS+ D+ V G L SE IAY+
Sbjct: 74 DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYIL 131
Query: 122 RETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
E L GL +LH +HRD+KG NILLT G VKL DFGV+A++T+T +R + +GTP+W
Sbjct: 132 HEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191
Query: 182 MAPEVAAVEK--NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPK 239
MAPEV A E+ + Y+ CD W++GITAIELG+ PP+ DLHPMRALF + ++ PPK
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPK 249
Query: 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
L+ WS+ F++F+ LTK+ +KRPT LL H F+ Q
Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,346,434
Number of Sequences: 37866
Number of extensions: 1626956
Number of successful extensions: 7685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 663
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 5337
Number of HSP's gapped (non-prelim): 1192
length of query: 846
length of database: 18,247,518
effective HSP length: 111
effective length of query: 735
effective length of database: 14,044,392
effective search space: 10322628120
effective search space used: 10322628120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.