Guide to the Human Genome
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Search of human proteins with 38570135

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38570135 mitogen-activated protein kinase kinase kinase
kinase 5 [Homo sapiens]
         (846 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38570135 mitogen-activated protein kinase kinase kinase kinas...  1731   0.0  
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...  1731   0.0  
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...  1174   0.0  
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   853   0.0  
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   739   0.0  
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...   719   0.0  
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 265   2e-70
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   263   5e-70
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   263   5e-70
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...   263   5e-70
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...   263   5e-70
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...   263   5e-70
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...   263   5e-70
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...   263   5e-70
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...   263   5e-70
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]     257   3e-68
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]     257   3e-68
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]     257   3e-68
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]      257   3e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      256   5e-68
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...   256   5e-68
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   256   5e-68
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...   256   5e-68
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       255   1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   254   3e-67
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 250   3e-66
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   250   4e-66
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                245   1e-64
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  233   7e-61
gi|145275208 myosin IIIA [Homo sapiens]                               228   1e-59

>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score = 1731 bits (4483), Expect = 0.0
 Identities = 846/846 (100%), Positives = 846/846 (100%)

Query: 1   MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
           MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
Sbjct: 1   MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60

Query: 61  LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
           LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
Sbjct: 61  LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120

Query: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
           CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
Sbjct: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180

Query: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
           WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
Sbjct: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240

Query: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
           KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
Sbjct: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300

Query: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
           AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
Sbjct: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360

Query: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
           SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
Sbjct: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420

Query: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
           SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
Sbjct: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480

Query: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
           PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
Sbjct: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540

Query: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
           LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
Sbjct: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600

Query: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
           FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
Sbjct: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660

Query: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
           IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
Sbjct: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720

Query: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
           AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
Sbjct: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780

Query: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
           SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
Sbjct: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840

Query: 841 GHENSY 846
           GHENSY
Sbjct: 841 GHENSY 846


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score = 1731 bits (4483), Expect = 0.0
 Identities = 846/846 (100%), Positives = 846/846 (100%)

Query: 1   MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60
           MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
Sbjct: 1   MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS 60

Query: 61  LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120
           LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
Sbjct: 61  LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV 120

Query: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
           CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
Sbjct: 121 CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180

Query: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
           WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
Sbjct: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240

Query: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300
           KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
Sbjct: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH 300

Query: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360
           AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
Sbjct: 301 AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL 360

Query: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420
           SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
Sbjct: 361 SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD 420

Query: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480
           SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
Sbjct: 421 SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 480

Query: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540
           PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
Sbjct: 481 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE 540

Query: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600
           LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
Sbjct: 541 LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR 600

Query: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660
           FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
Sbjct: 601 FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML 660

Query: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720
           IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
Sbjct: 661 IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG 720

Query: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780
           AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
Sbjct: 721 AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD 780

Query: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840
           SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
Sbjct: 781 SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA 840

Query: 841 GHENSY 846
           GHENSY
Sbjct: 841 GHENSY 846


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score = 1174 bits (3036), Expect = 0.0
 Identities = 592/899 (65%), Positives = 704/899 (78%), Gaps = 62/899 (6%)

Query: 5   LRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ 64
           + P  D+ RRNPQ+D+EL+QR+GSGTYGDVYKARNV+TGELAA+K+IKLEPG+DF+++QQ
Sbjct: 1   MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60

Query: 65  EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRET 124
           EI M+K+CKH NIVAYFGSYL R+KLWICME+CGGGSLQDIYHVTGPLSELQIAYV RET
Sbjct: 61  EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           LQGL YLH+KGKMHRDIKGANILLTD+G VKLADFGV+A+ITATIAKRKSFIGTPYWMAP
Sbjct: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180

Query: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
           EVAAVE+ GGYNQLCD+WAVGITAIEL ELQPPMFDLHPMRALFLM+KSNFQPPKLKDK 
Sbjct: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240

Query: 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYT 304
           KWS++FH+FVK+ALTKNPKKRPTAE+LL H FV Q  L+R+LA+ELLDKVNNPD H+ Y 
Sbjct: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH-LTRSLAIELLDKVNNPD-HSTYH 298

Query: 305 EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLS--- 361
           + DDDD EP   + H I ST+RN R E+T SEI F +++F+PPLRKETE   E+  S   
Sbjct: 299 DFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGF 358

Query: 362 ------------SDPNFMLQWNP-----FVDGANTG------------------------ 380
                       S+ +  L++       +  GAN                          
Sbjct: 359 LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGD 418

Query: 381 -----KSTSKRAIPPPLPPKPRISSYPED-NFPDEEKASTIKHCPDSESRA-PQILRRQS 433
                 ST K  IPPPLPPKP+    P++ +  ++E   TIK CP S S A P  +  + 
Sbjct: 419 DDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP 478

Query: 434 SPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPR-----KKDKRDFPKPAINGLPP 488
            P   P  +  ++GNG    +L  E      Q     R     +K+K+D PKP  NGLPP
Sbjct: 479 PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP 538

Query: 489 TPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQ 548
           TPKV MGACFSKVF+GCPLKI+CA+SWI+PDT+DQY+IFG E+GIYTLNLNELHE +MEQ
Sbjct: 539 TPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQ 598

Query: 549 LFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKK-PGLAAHIQTHRFPDRILP 607
           LFPR+CTWLYV+NN L+S+S GK  QLYSHNL  LF++A++   L   I  H+ PDRILP
Sbjct: 599 LFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILP 657

Query: 608 RKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFP 667
           RKF+++ KIP+TK C KCC+VRNPYTGHKYLCGALQ+ IVLL+W EPMQKFMLIKH DFP
Sbjct: 658 RKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFP 717

Query: 668 LPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLD 727
           +P PL +FEMLV+PEQEYP+VCV +S+G + NQVV+FET+N NS SSWFTE  + + Q +
Sbjct: 718 IPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTE--SDTPQTN 775

Query: 728 SIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWK 787
             HVTQLERDT+LVCLD  +KIVNLQG+LKSS+KL+SEL+FDF+IES+VCLQDSVLAFWK
Sbjct: 776 VTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWK 835

Query: 788 HGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY 846
           HGMQG+SF+S+EVTQEISD TR+FRLLGSDRVVVLESRPT+NPTA+SNLYILAGHENSY
Sbjct: 836 HGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  853 bits (2205), Expect = 0.0
 Identities = 448/850 (52%), Positives = 592/850 (69%), Gaps = 48/850 (5%)

Query: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
           D+  ++P+  +EL+QRVG+GTYGDVYKAR+  T ELAAVKI+KL+PGDD S +QQEI ++
Sbjct: 6   DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65

Query: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
           +EC+H N+VAY GSYL  ++LWICME+CGGGSLQ+IYH TGPL E QIAYVCRE L+GL 
Sbjct: 66  RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125

Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
           +LH++GK+HRDIKGAN+LLT  GDVKLADFGV+ ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185

Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
           E+ GGYN+LCD+WA+GITAIELGELQPP+F LHPMRAL LMSKS+FQPPKL+DKT+W+  
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245

Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
           FH+F+K+ALTKNPKKRPTAE+LL H F  Q  L RAL  +LLDK ++P  H      +D 
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDP--HLGTPSPEDC 302

Query: 310 DFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDE--------MGLS 361
           + E + +   TI S  ++  AERT SEI F +++F  P RKET+  +E        +G  
Sbjct: 303 ELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKE 362

Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
                +LQ    V  A   +S + R+           S + E + PD +   TIK     
Sbjct: 363 ELSGSLLQ---SVQEALEERSLTIRS----------ASEFQELDSPD-DTMGTIK----- 403

Query: 422 ESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLP----RKKDKRD 477
             RAP +    + P   P  E  S   G      +     G   +P LP      K + D
Sbjct: 404 --RAPFLGPLPTDP---PAEEPLSSPPG-----TLPPPPSGPNSSPLLPTAWATMKQRED 453

Query: 478 FPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLN 537
             + + +GLPPTPKV MGACFSKVF+GCPL+I+ A +WIHP T+DQ+++ G E+GIYTLN
Sbjct: 454 PERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLN 513

Query: 538 LNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAK-KPGLAAHI 596
           L+ELHE T+E+L   +C+WLY +NN L+SLS GK+  +++H+L  LFE  + +  +   I
Sbjct: 514 LHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRRLQQQVPLSI 572

Query: 597 QTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQ 656
            T+R   RI+PR+FAL+TKIPDTKGC +C +VRNPYTG  +L  AL + ++LLQWYEP+Q
Sbjct: 573 PTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQ 632

Query: 657 KFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF 716
           KF+L+K+F  PLPSP  + E LV+  +E P VCV           V F  + L +  +  
Sbjct: 633 KFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPD 692

Query: 717 TEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVV 776
             I        +  V Q++RDT+LV  ++ V+IVN+QG  + +  LA EL+FDF IE+VV
Sbjct: 693 ILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVV 750

Query: 777 CLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNL 836
           CLQDSVLAFW HGMQG+S  ++EVTQEI+DETR+FR+LG+ R ++LES PT+NP AHSNL
Sbjct: 751 CLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNL 810

Query: 837 YILAGHENSY 846
           YIL GH+++Y
Sbjct: 811 YILTGHQSTY 820


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  739 bits (1909), Expect = 0.0
 Identities = 397/846 (46%), Positives = 541/846 (63%), Gaps = 50/846 (5%)

Query: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
           DI  R+P+  Y+L+QR+G GTYG+V+KAR+  +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66

Query: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
           K C+H NIVAY GSYL  +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126

Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
           YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186

Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
              GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+ 
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246

Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
           FHNF+K+ LTK+PKKRP+A ++L+H  V+QPGL+R L ++LLDK+ NP       + +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306

Query: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
           + E    I   IRST+R++      A+     + F KL   +  PP             S
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366

Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
           S P   L  +   D  +    T     PPPLPPKP+  S P D  P            D 
Sbjct: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417

Query: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
              +P +L R       +SP  GP   TS        S  ++ ++E S   P        
Sbjct: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463

Query: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
           R+  KP +  LPP  + +     A   K+F+GCPL+I+   +W HP TKDQ+++ G E+G
Sbjct: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521

Query: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
           I+ LN N+  EAT+E LFP + TW+Y INN LMSLS GKT  LYSH+++ L E  +K   
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577

Query: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
           A +   H  P R+L RK  ++TKI DTKGC  CC+     +G  +LCGAL++ +VLLQWY
Sbjct: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637

Query: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
           +PM KF+L++   FPLP+PL+VF +L  P  E P VC+ +S G     V+ F T+   + 
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696

Query: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
           S W  E+   ++    + VTQ+E D V+V +D  VK+V  +G      +   E+     +
Sbjct: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753

Query: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
           E+V  +   + AFWKHG+Q  +  SD++ QE+ D T  FRLLGS R VV+E+RP ++PTA
Sbjct: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTA 813

Query: 833 HSNLYI 838
            SNLYI
Sbjct: 814 PSNLYI 819


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score =  719 bits (1855), Expect = 0.0
 Identities = 395/853 (46%), Positives = 537/853 (62%), Gaps = 56/853 (6%)

Query: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
           DI  R+P+  Y+L+QR+G GTYG+V+KAR+  +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66

Query: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129
           K C+H NIVAY GSYL  +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126

Query: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
           YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186

Query: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
              GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+ 
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246

Query: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309
           FHNF+K+ LTK+PKKRP+A ++L+H  V+QPGL+R L ++LLDK+ NP       + +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306

Query: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361
           + E    I   IRST+R++      A+     + F KL   +  PP             S
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366

Query: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421
           S P   L  +   D  +    T     PPPLPPKP+  S P D  P            D 
Sbjct: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417

Query: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475
              +P +L R       +SP  GP   TS        S  ++ ++E S   P        
Sbjct: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463

Query: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532
           R+  KP +  LPP  + +     A   K+F+GCPL+I+   +W HP TKDQ+++ G E+G
Sbjct: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521

Query: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592
           I+ LN N+  EAT+E LFP + TW+Y INN LMSLS GKT  LYSH+++ L E  +K   
Sbjct: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577

Query: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652
           A +   H  P R+L RK  ++TKI DTKGC  CC+     +G  +LCGAL++ +VLLQWY
Sbjct: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637

Query: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712
           +PM KF+L++   FPLP+PL+VF +L  P  E P VC+ +S G     V+ F T+   + 
Sbjct: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696

Query: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772
           S W  E+   ++    + VTQ+E D V+V +D  VK+V  +G      +   E+     +
Sbjct: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753

Query: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832
           E+V  +   + AFWKHG+Q  +  SD++ QE+ D T  FRLLGS R   LE   T +P  
Sbjct: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISP-- 808

Query: 833 HSNLYILAGHENS 845
           H NL +L G  NS
Sbjct: 809 HCNL-LLPGSSNS 820


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  265 bits (676), Expect = 2e-70
 Identities = 141/299 (47%), Positives = 193/299 (64%), Gaps = 9/299 (3%)

Query: 13  RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKE 71
           R +P++ +  + R+G G++G+VYK  + HT E+ A+KII LE  +D    IQQEI ++ +
Sbjct: 13  RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 72

Query: 72  CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131
           C    I  YFGSYL   KLWI MEY GGGS  D+    GPL E  IA + RE L+GL YL
Sbjct: 73  CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYL 131

Query: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEK 191
           H++ K+HRDIK AN+LL++ GDVKLADFGVA ++T T  KR +F+GTP+WMAPEV    K
Sbjct: 132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---K 188

Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
              Y+   DIW++GITAIEL + +PP  DLHPMR LFL+ K++  PP L+   + S  F 
Sbjct: 189 QSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPFK 244

Query: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
            FV+  L K+P+ RPTA+ LL H F+ +     +   EL+D+     +  H  E+  +D
Sbjct: 245 EFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSED 303


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score =  263 bits (672), Expect = 5e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77

Query: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255

Query: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314

Query: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364

Query: 350 KETEARDEM 358
            E   R ++
Sbjct: 365 SEALRRQQL 373


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score =  257 bits (657), Expect = 3e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63

Query: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123

Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183

Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243

Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 289 ELLDKVN 295
           +L D ++
Sbjct: 301 QLKDHID 307


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score =  257 bits (657), Expect = 3e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63

Query: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123

Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183

Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243

Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 289 ELLDKVN 295
           +L D ++
Sbjct: 301 QLKDHID 307


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score =  257 bits (657), Expect = 3e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63

Query: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123

Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183

Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243

Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 289 ELLDKVN 295
           +L D ++
Sbjct: 301 QLKDHID 307


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score =  257 bits (657), Expect = 3e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63

Query: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123

Query: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183

Query: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243

Query: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 289 ELLDKVN 295
           +L D ++
Sbjct: 301 QLKDHID 307


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  256 bits (655), Expect = 5e-68
 Identities = 133/305 (43%), Positives = 192/305 (62%), Gaps = 9/305 (2%)

Query: 7   PAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQE 65
           P    L+ +P++ +  ++++G G++G+V+K  +  T ++ A+KII LE  +D    IQQE
Sbjct: 11  PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70

Query: 66  IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETL 125
           I ++ +C    +  Y+GSYL   KLWI MEY GGGS  D+    GPL E QIA + RE L
Sbjct: 71  ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129

Query: 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPE 185
           +GL YLH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T  KR +F+GTP+WMAPE
Sbjct: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189

Query: 186 VAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTK 245
           V    K   Y+   DIW++GITAIEL   +PP  +LHPM+ LFL+ K+N  PP L+    
Sbjct: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242

Query: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTE 305
           +S     FV+  L K P  RPTA+ LL H F+ +     +   EL+D+         + +
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302

Query: 306 ADDDD 310
           +  +D
Sbjct: 303 SSSED 307


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score =  256 bits (655), Expect = 5e-68
 Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)

Query: 2   EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
           ++P +   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+
Sbjct: 4   DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62

Query: 59  FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
              I+ EI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T  
Sbjct: 63  EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122

Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
             L E  IAY+ RE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182

Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
            +R +FIGTPYWMAPEV A ++N    Y+   D+W+ GITAIE+ E  PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242

Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
           FL+ ++   PP+LK K KWS  F +F++  L KN  +RP+ E+LL H F+      R + 
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299

Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
           ++L D ++         E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  256 bits (655), Expect = 5e-68
 Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)

Query: 2   EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
           ++P +   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+
Sbjct: 4   DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62

Query: 59  FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
              I+ EI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T  
Sbjct: 63  EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122

Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
             L E  IAY+ RE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182

Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
            +R +FIGTPYWMAPEV A ++N    Y+   D+W+ GITAIE+ E  PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242

Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
           FL+ ++   PP+LK K KWS  F +F++  L KN  +RP+ E+LL H F+      R + 
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299

Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
           ++L D ++         E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score =  256 bits (655), Expect = 5e-68
 Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)

Query: 2   EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
           ++P +   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+
Sbjct: 4   DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62

Query: 59  FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
              I+ EI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T  
Sbjct: 63  EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122

Query: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
             L E  IAY+ RE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+
Sbjct: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182

Query: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
            +R +FIGTPYWMAPEV A ++N    Y+   D+W+ GITAIE+ E  PP+ D+HPMRAL
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242

Query: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
           FL+ ++   PP+LK K KWS  F +F++  L KN  +RP+ E+LL H F+      R + 
Sbjct: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299

Query: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
           ++L D ++         E D+ ++E
Sbjct: 300 IQLKDHIDR--TRKKRGEKDETEYE 322


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  255 bits (652), Expect = 1e-67
 Identities = 132/300 (44%), Positives = 191/300 (63%), Gaps = 9/300 (3%)

Query: 12  LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVK 70
           L+ +P++ +  ++++G G++G+V+K  +  T ++ A+KII LE  +D    IQQEI ++ 
Sbjct: 28  LKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLS 87

Query: 71  ECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAY 130
           +C    +  Y+GSYL   KLWI MEY GGGS  D+    GPL E QIA + RE L+GL Y
Sbjct: 88  QCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDY 146

Query: 131 LHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE 190
           LH++ K+HRDIK AN+LL++HG+VKLADFGVA ++T T  KR +F+GTP+WMAPEV    
Sbjct: 147 LHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 203

Query: 191 KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTF 250
           K   Y+   DIW++GITAIEL   +PP  +LHPM+ LFL+ K+N  PP L+    +S   
Sbjct: 204 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--NYSKPL 259

Query: 251 HNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
             FV+  L K P  RPTA+ LL H F+ +     +   EL+D+         + ++  +D
Sbjct: 260 KEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSED 319


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  254 bits (648), Expect = 3e-67
 Identities = 130/297 (43%), Positives = 188/297 (63%), Gaps = 9/297 (3%)

Query: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
           +P++ +  ++R+G G++G+V+K  +  T ++ A+KII LE  +D    IQQEI ++ +C 
Sbjct: 19  DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 74  HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
              +  Y+GSYL   KLWI MEY GGGS  D+    GP  E QIA + +E L+GL YLH+
Sbjct: 79  SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137

Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
           + K+HRDIK AN+LL++ GDVKLADFGVA ++T T  KR +F+GTP+WMAPEV    +  
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQS 194

Query: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
            Y+   DIW++GITAIEL + +PP  D+HPMR LFL+ K+N  PP L     ++ +F  F
Sbjct: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEF 250

Query: 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
           +   L K+P  RPTA+ LL H F+ +     +   EL+D+        H  +  D +
Sbjct: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 307


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  250 bits (639), Expect = 3e-66
 Identities = 141/353 (39%), Positives = 212/353 (60%), Gaps = 25/353 (7%)

Query: 1   MEAPLRPAA-------DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL 53
           ME P  P +       D L + P++ +++++++G G+YG V+KA +  +G++ A+K + +
Sbjct: 1   MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60

Query: 54  EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-L 112
           E   D   I +EI ++++C    +V Y+GSY     LWI MEYCG GS+ DI  +    L
Sbjct: 61  E--SDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118

Query: 113 SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
            E +IA + + TL+GL YLH   K+HRDIK  NILL   G  KLADFGVA ++T T+AKR
Sbjct: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178

Query: 173 KSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK 232
            + IGTP+WMAPEV    +  GYN + DIW++GIT+IE+ E +PP  D+HPMRA+F++  
Sbjct: 179 NTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 235

Query: 233 SNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV--AQP-GLSRALAVE 289
           +   PP  +    WS  F +FVK  L KNP++R TA +LL H F+  A+P  + R L  E
Sbjct: 236 N--PPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293

Query: 290 LLD-KVNNPDNHAHYTE-----ADDDDFEPHAIIRHTIRSTNRNARAERTASE 336
            ++ K    +      E     +D+D+ + H +++ ++ S     RA  T SE
Sbjct: 294 AMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVG-TMRATSTMSE 345


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  250 bits (638), Expect = 4e-66
 Identities = 133/306 (43%), Positives = 197/306 (64%), Gaps = 12/306 (3%)

Query: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69
           D L + P++ +++++++G G+YG VYKA +  TG++ A+K + +E   D   I +EI ++
Sbjct: 20  DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77

Query: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-LSELQIAYVCRETLQGL 128
           ++C   ++V Y+GSY     LWI MEYCG GS+ DI  +    L+E +IA + + TL+GL
Sbjct: 78  QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137

Query: 129 AYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAA 188
            YLH   K+HRDIK  NILL   G  KLADFGVA ++T T+AKR + IGTP+WMAPEV  
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196

Query: 189 VEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSS 248
             +  GYN + DIW++GITAIE+ E +PP  D+HPMRA+F++  +   PP  +    WS 
Sbjct: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252

Query: 249 TFHNFVKIALTKNPKKRPTAERLLTHTFV-AQPGLS--RALAVELLD-KVNNPDNHAHYT 304
            F +FVK  L K+P++R TA +LL H FV +  G+S  R L  E +D K+   ++     
Sbjct: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312

Query: 305 EADDDD 310
           + DD++
Sbjct: 313 DQDDEE 318


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  245 bits (625), Expect = 1e-64
 Identities = 164/470 (34%), Positives = 246/470 (52%), Gaps = 26/470 (5%)

Query: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
           +P + +E+V  +G G +G VYKA+N  TG LAA K+I+ +  ++      EI ++  C H
Sbjct: 31  DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90

Query: 75  CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
             IV   G+Y    KLWI +E+C GG++  I   +   L+E QI  VCR+ L+ L +LH+
Sbjct: 91  PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150

Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
           K  +HRD+K  N+L+T  GD++LADFGV+AK   T+ KR SFIGTPYWMAPEV   E  K
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210

Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
           +  Y+   DIW++GIT IE+ +++PP  +L+PMR L  ++KS+  PP L   +KWS  F 
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268

Query: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDF 311
           +F+KIAL KNP+ RP+A +LL H FV+    ++AL  EL+ +             D+ + 
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALR-ELVAEAKAEVMEEIEDGRDEGEE 327

Query: 312 EPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL-------SSDP 364
           E       T+ +  +N+ +E +   +N DK   E P      ++ +  +       S D 
Sbjct: 328 EDAVDAASTLENHTQNS-SEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDR 386

Query: 365 NFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESR 424
           +      P V   N     +  A+P PL     +S         E++ +           
Sbjct: 387 SLQTTSPPVVAPGN----ENGLAVPVPLRKSRPVSMDARIQVAQEKQVA-----EQGGDL 437

Query: 425 APQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKD 474
           +P   R Q +    P    SS     G  KL + + E  AQA   P K+D
Sbjct: 438 SPAANRSQKASQSRP---NSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  233 bits (593), Expect = 7e-61
 Identities = 119/266 (44%), Positives = 166/266 (62%), Gaps = 5/266 (1%)

Query: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
           NP+  +E++  +G G +G VYKA+N  T  LAA K+I  +  ++      EI ++  C H
Sbjct: 29  NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88

Query: 75  CNIVAYFGSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHT 133
            NIV    ++     LWI +E+C GG++  +   +  PL+E QI  VC++TL  L YLH 
Sbjct: 89  PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148

Query: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--K 191
              +HRD+K  NIL T  GD+KLADFGV+AK T TI +R SFIGTPYWMAPEV   E  K
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208

Query: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251
           +  Y+   D+W++GIT IE+ E++PP  +L+PMR L  ++KS  +PP L   ++WSS F 
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266

Query: 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
           +F+K  L KN   R T  +LL H FV
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFV 292


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  228 bits (582), Expect = 1e-59
 Identities = 126/280 (45%), Positives = 176/280 (62%), Gaps = 21/280 (7%)

Query: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECK 73
           +P   +E+ + +G GTYG V+K  N   G+ AAVKI  L+P  D    I+ E  ++K   
Sbjct: 16  DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73

Query: 74  -HCNIVAYFGSYLSREK-----LWICMEYCGGGSLQDIYHVTGPL------SELQIAYVC 121
            H N+V ++G Y  ++K     LW+ +E C GGS+ D+  V G L      SE  IAY+ 
Sbjct: 74  DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYIL 131

Query: 122 RETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
            E L GL +LH    +HRD+KG NILLT  G VKL DFGV+A++T+T  +R + +GTP+W
Sbjct: 132 HEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191

Query: 182 MAPEVAAVEK--NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPK 239
           MAPEV A E+  +  Y+  CD W++GITAIELG+  PP+ DLHPMRALF + ++   PPK
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPK 249

Query: 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
           L+    WS+ F++F+   LTK+ +KRPT   LL H F+ Q
Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,346,434
Number of Sequences: 37866
Number of extensions: 1626956
Number of successful extensions: 7685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 663
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 5337
Number of HSP's gapped (non-prelim): 1192
length of query: 846
length of database: 18,247,518
effective HSP length: 111
effective length of query: 735
effective length of database: 14,044,392
effective search space: 10322628120
effective search space used: 10322628120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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